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Sample records for tipo ts expresso

  1. Receptor desencadeador expresso nas células mielóides Tipo 1 (TREM-1) no diagnóstico e prognóstico na meningite bacteriana em crianças

    OpenAIRE

    Vitor Félix Torres

    2015-01-01

    Base teórica: A meningite bacteriana é uma causa importante de morbidade e mortalidade na infância. Análise do líquido cefalorraquidiano (LCR) continua a ser a ferramenta de diagnóstico padrão ouro, porém novos biomarcadores para o diagnóstico e prognóstico ainda são necessários. Receptor Desencadeador Expresso nas Células Mielóides Tipo 1 (TREM-1) é um receptor transmembrana expresso em neutrófilos e monócitos, que desempenha um papel importante na modulação da resposta inflamatória. A sua f...

  2. Estereótipos que refletem identidades de gênero e orientação sexual expressos por estudantes de 1º ano do ensino médio

    Directory of Open Access Journals (Sweden)

    LUDMILA AMENO RIBEIRO

    2015-08-01

    Full Text Available Este artigo apresenta os resultados de um estudo piloto que procurou levantar os estereótipos emergentes do discurso de 18 estudantes de 1º ano do Ensino Médio de uma escola regular de Belo Horizonte. Os informantes tiveram acesso a 33 imagens pertencentes a cinco categorias: (1 família heterossexual e família homoafetiva; (2 papel social dos gêneros; (3 orientação afetivo sexual dos gêneros; (4 expressões de gêneros; e (5 comportamento social dos gêneros. Por meio de um quadro, registraram a impressão que tiveram ao lidar com cada uma. Com base na Teoria Queer, verificou-se que a visão predominante reflete o padrão heteronormativo de relações humanas – a despeito de lidarem com a multiplicidade de identidades e de expressões de gêneros sexuais, esses estudantes fazem julgamentos de valor e agem de forma preconceituosa. Parece necessário que a escola enfrente abertamente as questões de identidade e de orientação sexual para efetivamente cumprir sua função social.

  3. TS-EUROTRAIN

    DEFF Research Database (Denmark)

    Forde, Natalie J; Kanaan, Ahmad S; Widomska, Joanna

    2016-01-01

    Gilles de la Tourette Syndrome (GTS) is characterized by the presence of multiple motor and phonic tics with a fluctuating course of intensity, frequency, and severity. Up to 90% of patients with GTS present with comorbid conditions, most commonly attention-deficit/hyperactivity disorder (ADHD......), and obsessive-compulsive disorder (OCD), thus providing an excellent model for the exploration of shared etiology across disorders. TS-EUROTRAIN (FP7-PEOPLE-2012-ITN, Grant Agr.No. 316978) is a Marie Curie Initial Training Network (http://ts-eurotrain.eu) that aims to elucidate the complex etiology of the onset...... and clinical course of GTS, investigate the neurobiological underpinnings of GTS and related disorders, translate research findings into clinical applications, and establish a pan-European infrastructure for the study of GTS. This includes the challenges of (i) assembling a large genetic database...

  4. O MARKETING SOCIAL COMO DIFERENCIAL COMPETITIVO: O CASO DA EMPRESA EXPRESSO GUANABARA

    Directory of Open Access Journals (Sweden)

    Patrícia Grenfell Oliveira

    2015-12-01

    Full Text Available Nos últimos anos as organizações têm demonstrado grande preocupação com as questões sociais e os conflitos ambientais que cercam nossa sociedade. Neste contexto surge o conceito de responsabilidade social e o marketing social, como um campo de atuação inspirado na ideia de sustentabilidade, capaz de alavancar a imagem e a marca da organização, além de ser uma diferencial perante seus concorrentes. Desta forma, a presente pesquisa teve como principal objetivo verificar a percepção dos clientes da Empresa Expresso Guanabara sobre o marketing social como diferencial competitivo. Trata-se de uma pesquisa com abordagem quali-quantitativa, de cunho exploratório e descritivo, fazendo uso do método estudo de caso. O marketing social pode ser visto como um diferencial competitivo que visa favorecer a organização e sua imagem perante seus stakeholders. Os resultados evidenciam que os clientes da empresa ainda não utilizam seus serviços pelo fato desta ser socialmente responsável e desenvolver estratégias de marketing social. Desta forma, concluir-se que na empresa estudada o marketing social ainda não é compreendido como um diferencial competitivo perante seus clientes e gestores.

  5. Tourette Syndrome (TS): Risk Factors and Causes

    Science.gov (United States)

    ... having TS. The causes of TS and other tic disorders are not well understood. Although the risk factors ... Psychiatry. 2017; 74(7): 740-746. Related Links Attention-Deficit/Hyperactivity Disorder (ADHD) Child Development Positive Parenting Tips A-Z ...

  6. TS LOOP ALCOVE VENTILATION ANALYSIS

    International Nuclear Information System (INIS)

    T.M. Lahnalampi

    2000-01-01

    The scope of this analysis is to examine the existing, constructor installed, physical ventilation installations located in each of the Exploratory Studies Facility (ESF) Topopah Springs (TS) Loop Alcoves No.1, No.2, No.3, No.4, No.6, and No.7. Alcove No.5 is excluded from the scope of this analysis since it is an A/E design system. Each ventilation installation will be analyzed for the purpose of determining if requirements for acceptance into the A/E design technical baseline have been met. The ventilation installations will be evaluated using Occupational Safety and Health Administration (OSHA) standards and Exploratory Studies Facility Design Requirements (ESFDR) (YMP 1997) requirements. The end product will be a technical analysis that will define ventilation installation compliance issues, any outstanding field changes, and use-as-is design deviations that are required to bring the ventilation installations into compliance with requirements for acceptance into the A/E design technical baseline. The analysis will provide guidance for alcove ventilation component design modifications to be developed to correct any deficient components that do not meet minimum requirements and standards

  7. Expresso: A database and web server for exploring the interaction of transcription factors and their target genes inArabidopsis thalianausing ChIP-Seq peak data.

    Science.gov (United States)

    Aghamirzaie, Delasa; Raja Velmurugan, Karthik; Wu, Shuchi; Altarawy, Doaa; Heath, Lenwood S; Grene, Ruth

    2017-01-01

    Motivation: The increasing availability of chromatin immunoprecipitation sequencing (ChIP-Seq) data enables us to learn more about the action of transcription factors in the regulation of gene expression. Even though in vivo transcriptional regulation often involves the concerted action of more than one transcription factor, the format of each individual ChIP-Seq dataset usually represents the action of a single transcription factor. Therefore, a relational database in which available ChIP-Seq datasets are curated is essential. Results: We present Expresso (database and webserver) as a tool for the collection and integration of available Arabidopsis ChIP-Seq peak data, which in turn can be linked to a user's gene expression data. Known target genes of transcription factors were identified by motif analysis of publicly available GEO ChIP-Seq data sets. Expresso currently provides three services: 1) Identification of target genes of a given transcription factor; 2) Identification of transcription factors that regulate a gene of interest; 3) Computation of correlation between the gene expression of transcription factors and their target genes. Availability : Expresso is freely available at http://bioinformatics.cs.vt.edu/expresso/.

  8. Clustering of TS-fuzzy system

    OpenAIRE

    Igrejas, Getúlio; Salgado, Paulo

    2007-01-01

    This paper presents a fuzzy c-means clustering method for partitioning symbolic interval data, namely the T-S fuzzy rules. The proposed method furnish a fuzzy partition and prototype for each cluster by optimizing an adequacy criterion based on suitable squared Euclidean distances between vectors of intervals. This methodology leads to a fuzzy partition of the TS-fuzzy rules, one for each cluster, which corresponds to a new set of fuzzy sub-systems. When applied to the clustering of TS-fuzzy ...

  9. Do's and Don'ts for Liposuction

    Science.gov (United States)

    ... for Every Season How to Choose the Best Skin Care Products In This Section Dermatologic Surgery What is dermatologic ... for Every Season How to Choose the Best Skin Care Products Do's and don’ts for liposuction Don’t ...

  10. TS/EL ELECTRICAL WORK REQUEST FORM

    CERN Multimedia

    TS Department

    2008-01-01

    To facilitate the processing of requests for minor electrical installation work to be carried out by the TS/EL group, a new procedure designed to improve contacts and exchange of information with customers has been set up. The procedure comprises a check to determine whether the TS/EL or the TS/FM group is responsible for the area where the electrical work is to be done. If the work is to be performed by the EL group, an on-line request form must be completed. The following steps must be completed: On a web browser, use the link http://ts-dep.web.cern.ch/ts-dep/groups/el/el.htm In the left-hand menu choose ‘Demande de Travaux Electriques’ Enter the building number to check which group to contact and click ‘FIND’ If the area is: Under FM’s responsibility:\tCall 77777 Under EL’s responsibility:\tClick the link to the work form, complete it and send it (click ‘ENVOYER’) IMPORTANT This form is for minor electrical installation requests only. Please call 72201 in t...

  11. Tourette Syndrome (TS): Other Concerns and Conditions

    Science.gov (United States)

    ... or misbehavior. Learn more about oppositional defiant disorder » Conduct Disorder (CD) Children with CD act aggressive toward others and break ... disruptive for the child and others in the child’s life. It is important to get ... conduct disorder » Rage Some people with TS have anger that ...

  12. T.S. Eliot i nordisk efterkrigstidsdigtning

    DEFF Research Database (Denmark)

    Larsen, Peter Stein

    2009-01-01

    Hvad er årsagen til, at T.S. Eliot måske mere end nogen anden digter har haft indflydelse på nordiske digtere i det 20. århundrede? Dette vil blive undersøgt i tre tempi i denne artikel. For det første gives der et generelt rids af, hvor man finder T.S. Eliots aftryk i nordisk litteratur. For det...... andet indkredses den særlige fascinationskraft ved Eliots æstetik, som den kommer til udtryk i The Waste Land (1922), nemlig at der er tale om en uhyre sofistikeret brug af montageformen. For det tredje peges der gennem et par digtlæsninger på, hvordan Eliots montage-æstetik kan følges i nordisk poesi...

  13. Sonic boom research: TsAGI approach

    OpenAIRE

    Chernyshev, S. L.; Ivanteeva, L. G.; Kovalenko, V. V.; Teperin, L. L.; Chernyshev, S. L.; Ivanteeva, L. G.; Kovalenko, V. V.; Teperin, L. L.

    2000-01-01

    Research into sonic booms is indispensable for the future supersonic flight. In particular, the issue of sonic boom becomes a crucial problem when supersonic flights are over thickly populated areas. The TsAGI (Russia Central Aerohydrodynamic Institute) has been studying the sonic boom problem theoretically, experimentally and numerically since 1960. Prof. Zhirin of this institute has developed a theory of sonic boom by aircraft flying along any specified trajectory in non-homogeneous atmosph...

  14. Bureau de documentation TS/EL/DO

    CERN Document Server

    Dujardin, M

    2004-01-01

    Le bureau de documentation a comme responsabilité de fournir et manager toute la documentation nécessaire au groupe TS-EL. Ce travail utilise des outils CAO (EUCLID- AUTOCAD) et de gestion de base de donnés ORACLE (GESMAR,EDMS) largement utilisé dans le département TS mais aussi des applications métiers tel que le transfert des donnés CAO vers les bases de données, le cheminement automatique ou la schématique électrique. La section se concentre sur des études de grands ensembles et l'intégration 3D des équipements électriques. Les études de services généraux sont généralement sous-traitées. Le projet LHC occupe actuellement la quasi totalité de nos ressources. Pour mener à bien les études électriques du LHC, caractérisées par une définition tardive des besoins et de nombreuses modifications, une structure souple et réactive a été mis en place : Une cellule CAO 3D EUCLID, en charge des layouts d'équipements et des cheminements, en relation avec l'intégration, et une cellule d'é...

  15. High temperature facility TS-3000 K

    International Nuclear Information System (INIS)

    Ion, M.; Padureanu, I.; Mateescu, G.; Radulescu, G.

    1998-01-01

    The high temperature facility TS-3000 K is designed for inelastic and quasielastic slow neutron scattering and neutron diffraction experiments in condensed matter studies over a very large temperature range. A large class of materials is proposed for such kind of investigations: 1. Investigation of oxygen disorder, thermal parameters, lattice vibrations and elastic constants of nuclear fuel oxides as UO 2 , ThO 2 , PuO 2 at temperatures up to 3000 K; 2. Large and small angle neutron scattering experiments on disordered materials; 3. Investigation of the fast ion conductor lattice dynamics (superionic) using neutron scattering techniques; 4. Structure and dynamics of the liquid metals and alloys both in high purity state and with various impurities; 5. Investigation of the materials for fusion reactors at temperatures up to 3000 K; 6. Neutron - dynamics studies of the carbon lattice, its modifications, as well as fullerenes, at high temperature; 7. High temperature mass spectrometric measurements; 8. High purity materials. The facility TS-3000 is running under high internal vacuum conditions (under 10 -6 mbar), water cooled, automatically controlled and stabilized within a very large temperature range (Tmax = 3000 K) for samples of 80 x 80 mm size for inelastic neutron scattering or of a smaller size for diffraction investigation. The temperature is measured either by a wolfram - 5% Rh thermocouple or by direct viewing IR electronic thermometer. First investigations are planned at high intensity and resolution spectrometric complex DIN-2PI setup at the fast pulsed reactor IBR-2 of the Joint Institute for Nuclear Research, Dubna. The main parts of the TS-3000 K facility are: - The furnace with tungsten heater, tungsten, niobium or tantalum shields positioned in an accurate geometry depending of the temperature range and neutron optics (Tmax=3000 K); - The power supply assembly, data acquisition and storage, automatic or manual control; - The power three

  16. The TS 600: automatic control system for eddy currents

    International Nuclear Information System (INIS)

    Poulet, J.P.

    1986-10-01

    In the scope of fabrication and in service inspection of the PWR steam generator tubing bendle, FRAMATOME developed an automatic Eddy Current testing system: TS600. Based on a mini-computer, TS600 allows to digitize, to store and to process data in various ways, so it is possible to perform several kinds of inspection: conventional inservice inspection, roll area profilometry...... TS600 can also be used to develop new methods of examination [fr

  17. Electrophysiological Characterization of Ts6 and Ts7, K+ Channel Toxins Isolated through an Improved Tityus serrulatus Venom Purification Procedure

    Directory of Open Access Journals (Sweden)

    Felipe A. Cerni

    2014-02-01

    Full Text Available In Brazil, Tityus serrulatus (Ts is the species responsible for most of the scorpion related accidents. Among the Ts toxins, the neurotoxins with action on potassium channels (α-KTx present high interest, due to their effect in the envenoming process and the ion channel specificity they display. The α-KTx toxins family is the most relevant because its toxins can be used as therapeutic tools for specific target cells. The improved isolation method provided toxins with high resolution, obtaining pure Ts6 and Ts7 in two chromatographic steps. The effects of Ts6 and Ts7 toxins were evaluated in 14 different types of potassium channels using the voltage-clamp technique with two-microelectrodes. Ts6 toxin shows high affinity for Kv1.2, Kv1.3 and Shaker IR, blocking these channels in low concentrations. Moreover, Ts6 blocks the Kv1.3 channel in picomolar concentrations with an IC50 of 0.55 nM and therefore could be of valuable assistance to further designing immunosuppressive therapeutics. Ts7 toxin blocks multiple subtypes channels, showing low selectivity among the channels analyzed. This work also stands out in its attempt to elucidate the residues important for interacting with each channel and, in the near future, to model a desired drug.

  18. Identification and characterization of a Bacillus subtilis strain TS06 ...

    African Journals Online (AJOL)

    Replant disease is a major limitation for strawberry production in greenhouse. Bio-control may be a good way to cope with the replant diseases. Here, we report identification and characterization of a bacterial strain TS06 that may be used as a bio-control agent against the replant diseases in strawberry. TS06 was identified ...

  19. Identificação de transcritos diferencialmente expressos por Pasteurella multocida em condições de privação de ferro

    Directory of Open Access Journals (Sweden)

    Mayara I.V. Silva

    Full Text Available RESUMO: Ferro (Fe é um elemento essencial e a capacidade de adquiri-lo in vivo têm sido descrita em diversos agentes patogênicos através de fatores de virulência. Análises de transcritos durante a privação de Fe tem sido descritos através da técnica de "microarray", entretanto a técnica de RNA-seq recentemente tem demonstrado resultados superiores. Neste trabalho, o isolado de Pasteurella multocida (Pm 16759 altamente patogênico em suínos foi cultivado em duas condições com diferentes concentrações de Fe (controle e privação com o objetivo de analisar transcritos diferencialmente expressos. O RNA total das duas condições foi extraído e sequenciado através da plataforma de nova geração Ion Torrent. Os dados foram analisados no Software Ion Reporter(tm e processados no programa Rockhopper. Foram obtidas 1.341.615 leituras com tamanho médio de 81pb, com 96% de alinhamento com o genoma de Pasteurella multocida subsp. multocida 3480 e 98,8% de acurácia. No mapeamento das leituras das duas condições, observou-se 2,652 transcritos e destes, 177 (6,7% foram diferencialmente expressos, sendo 93 na condição controle (Fe+ e 84 na condição de privação (Fe-. Na condição de privação de Fe, o perfil de transcritos foram associados a função de transporte celular (fbp ABC, permease de alta afinidade com Fe2+/Pb2+ e proteína periplasmática de alta afinidade com Fe2+ , reguladores transcricionais e proteínas hipotéticas. O perfil na condição controle (Fe+ apresentou transcritos diferencialmente expressos associados ao RNAs anti-sense (asRNA e genes do metabolismo energético (fructose-1,6-bisfosfatase. O estudo comprovou que a restrição de Fe aumenta a expressão de genes envolvidos no transporte celular, reguladores transcricionais, proteínas hipotéticas e desconhecidas e permitiu ainda a identificação de novos genes como a permease de alta afinidade com Fe2+/Pb2+ e proteina periplasmática de alta afinidade

  20. TS LOOP NON-POTABLE PUMP EVALUATION

    Energy Technology Data Exchange (ETDEWEB)

    S. Goodin

    1999-05-14

    This analysis evaluates the existing subsurface non-potable water system from the portal pump to the end of the water line in the South Ramp and determines if the pump size and spacing meets the system pressure and flow requirements for construction operations and incipient fire fighting capability as established in the Subsurface Fire Hazards Analysis (CRWMS M&O 1998b). This analysis does not address the non potable water system in the Cross Drift which is covered under a previous design analysis (CRWMS-M&O 1998a). The Subsurface Fire Hazards Analysis references sections of OSHA 29 CFR 1910 Subpart L for requirements applicable to the incipient fire fighting hose stations used underground. This analysis does not address mechanical system valves, fittings, risers and other components of the system piping. This system is not designed or intended to meet all National Fire Protection Association (NFPA) codes for a fire fighting system but is only considered a backup system to fire extinguishers that are installed throughout the Topopah Springs (TS) Loop and may be used to fight small incipient stage fires.

  1. TS LOOP NON-POTABLE PUMP EVALUATION

    International Nuclear Information System (INIS)

    S. Goodin

    1999-01-01

    This analysis evaluates the existing subsurface non-potable water system from the portal pump to the end of the water line in the South Ramp and determines if the pump size and spacing meets the system pressure and flow requirements for construction operations and incipient fire fighting capability as established in the Subsurface Fire Hazards Analysis (CRWMS M andO 1998b). This analysis does not address the non potable water system in the Cross Drift which is covered under a previous design analysis (CRWMS-M andO 1998a). The Subsurface Fire Hazards Analysis references sections of OSHA 29 CFR 1910 Subpart L for requirements applicable to the incipient fire fighting hose stations used underground. This analysis does not address mechanical system valves, fittings, risers and other components of the system piping. This system is not designed or intended to meet all National Fire Protection Association (NFPA) codes for a fire fighting system but is only considered a backup system to fire extinguishers that are installed throughout the Topopah Springs (TS) Loop and may be used to fight small incipient stage fires

  2. LIDAR TS for ITER core plasma. Part II: simultaneous two wavelength LIDAR TS

    Science.gov (United States)

    Gowers, C.; Nielsen, P.; Salzmann, H.

    2017-12-01

    We have shown recently, and in more detail at this conference (Salzmann et al) that the LIDAR approach to ITER core TS measurements requires only two mirrors in the inaccessible port plug area of the machine. This leads to simplified and robust alignment, lower risk of mirror damage by plasma contamination and much simpler calibration, compared with the awkward and vulnerable optical geometry of the conventional imaging TS approach, currently under development by ITER. In the present work we have extended the simulation code used previously to include the case of launching two laser pulses, of different wavelengths, simultaneously in LIDAR geometry. The aim of this approach is to broaden the choice of lasers available for the diagnostic. In the simulation code it is assumed that two short duration (300 ps) laser pulses of different wavelengths, from an Nd:YAG laser are launched through the plasma simultaneously. The temperature and density profiles are deduced in the usual way but from the resulting combined scattered signals in the different spectral channels of the single spectrometer. The spectral response and quantum efficiencies of the detectors used in the simulation are taken from catalogue data for commercially available Hamamatsu MCP-PMTs. The response times, gateability and tolerance to stray light levels of this type of photomultiplier have already been demonstrated in the JET LIDAR system and give sufficient spatial resolution to meet the ITER specification. Here we present the new simulation results from the code. They demonstrate that when the detectors are combined with this two laser, LIDAR approach, the full range of the specified ITER core plasma Te and ne can be measured with sufficient accuracy. So, with commercially available detectors and a simple modification of a Nd:YAG laser similar to that currently being used in the design of the conventional ITER core TS design mentioned above, the ITER requirements can be met.

  3. Screening Fusion Tags for Improved Recombinant Protein Expression in E. coli with the Expresso® Solubility and Expression Screening System.

    Science.gov (United States)

    Steinmetz, Eric J; Auldridge, Michele E

    2017-11-01

    The simplicity, speed, and low cost of bacterial culture make E. coli the system of choice for most initial trials of recombinant protein expression. However, many heterologous proteins are either poorly expressed in bacteria, or are produced as incorrectly folded, insoluble aggregates that lack the activity of the native protein. In many cases, fusion to a partner protein can allow for improved expression and/or solubility of a difficult target protein. Although several different fusion partners have gained favor, none are universally effective, and identifying the one that best improves soluble expression of a given target protein is an empirical process. This unit presents a strategy for parallel screening of fusion partners for enhanced expression or solubility. The Expresso® Solubility and Expression Screening System includes a panel of seven distinct fusion partners and utilizes an extremely simple cloning strategy to enable rapid screening and identification of the most effective fusion partner. © 2017 by John Wiley & Sons, Inc. Copyright © 2017 John Wiley & Sons, Inc.

  4. Perfil sorológico das amostras de Clostridium botulinum tipos C e D utilizadas para produção de imunógenos no Brasil

    Directory of Open Access Journals (Sweden)

    Almeida A.C.

    2000-01-01

    Full Text Available Com o objetivo de avaliar o perfil sorológico de três amostras de Clostridium botulinum tipo C e três do tipo D utilizadas para produção de imunógenos no Brasil, determinou-se o índice de eficiência e o grau de homologia sorológica dentro de cada tipo. O índice de eficiência mostrou a mesma tendência para os dois tipos. Os consumos relativos de antitoxinas foram proporcionais nos níveis de 20, 200 e 1000 DL50, verificados através de curvas de neutralização que apresentaram inclinações semelhantes. A quantificação da variação do consumo de antitoxinas expresso em grau de homologia sorológica reflete uma similaridade relativa entre as amostras, sendo neutralizados 80 a 91,5% de determinantes antigênicos para o tipo C e 85 a 95% para o tipo D. Pelos resultados apresentados, as amostras analisadas comportaram-se como variantes sorológicas nos níveis de testes de 20, 200 e 1000 DL50.

  5. Gangliosidosis generalizada tipo 1

    Directory of Open Access Journals (Sweden)

    Iván Hernández García

    Full Text Available La gangliosidosis generalizada tipo 1 es una enfermedad de acúmulo lisosomal producida por mutaciones en el gen de la enzima b-galactosidasa, caracterizada fundamentalmente por toma del sistema nervioso central, la visceromegalia, disostosis ósea y dimorfismo facial. Se presenta el caso de un lactante varón, hijo de padres no consanguíneos, de 5 meses de edad, Apgar 6/8 debido a hipoxia neonatal, con historia de múltiples ingresos por enfermedad diarreica e infecciones respiratorias. Es remitido a la Consulta de Genética Clínica por retardo del desarrollo psicomotor, macrocráneo y hepatomegalia, además de máculas hipercrómicas en piel. En el examen físico se encontraron evidencias de una posible afectación por enfermedad metabólica lisosomal. Entre las enfermedades a descartar estaban la galactosialidosis, de características clínicas similares, y la enfermedad de Morquio, con diferente presentación clínica pero idéntico defecto enzimático.

  6. TS WEBSITE AND SOCIAL MEDIA ANALYTICS- DECEMBER 2016

    Data.gov (United States)

    Department of Veterans Affairs — This PowerPoint included accomplishments reached in December 2016, along with how many TS users and Pulse users there are currently. Not only does this PowerPoint...

  7. TS WEBSITE AND SOCIAL MEDIA ANALYTICS NOVEMBER 2016

    Data.gov (United States)

    Department of Veterans Affairs — This PowerPoint included accomplishments reached in November 2016, along with how many TS users and Pulse users there are currently. Not only does this PowerPoint...

  8. mellitus tipo 2

    Directory of Open Access Journals (Sweden)

    Margarita Lazcano-Ortiz

    2008-01-01

    Full Text Available Objetivo: valorar las propiedades psicométricas de la escala de afrontamiento y proceso de adaptación de Roy en población mexicana. Materiales y métodos: la escala se aplicó a 200 participantes con diabetes mellitus tipo 2. Para validar el constructo se realizó la extracción de factores con componentes principales y rotación Varimax, con Eigenvalores por arriba de 1 y cargas de factor mayores a ,30. Resultados: seis reactivos fueron eliminados del análisis por mostrar correlación negativa con la correlación total de la escala. El análisis de componentes principales inicial reveló nueve factores con una variación explicada de 65,29%. Sin embargo, no se consideraron tres factores por contener cada uno de ellos solamente un reactivo. Por tanto, la escala final se acepta con 38 reactivos. El coeficiente de confiabilidad Alfa de Cronbach fue de, 93. Discusión: el análisis reveló seis factores, uno más de lo reportado por Roy, y con mayor variación explicada. Algunos reactivos parecen no ser bien comprendidos por los participantes. Conclusiones: este artículo aporta una aproximación metodológica para explorar la adecuación de un instrumento a una población diferente para la que originalmente fue diseñado. Se concluye que la escala tiene consistencia interna y validez de constructo incipiente, los datos reportados en este estudio deben tomarse en cuenta con cautela. Es conveniente revisar de nuevo los reactivos y adecuarlos a la cultura particular, y probar la escala de nuevo con pacientes con enfermedades crónicas degenerativas a fin de contar con instrumentos culturalmente equivalentes.

  9. Functional and structural study comparing the C-terminal amidated β-neurotoxin Ts1 with its isoform Ts1-G isolated from Tityus serrulatus venom.

    Science.gov (United States)

    Coelho, V A; Cremonez, C M; Anjolette, F A P; Aguiar, J F; Varanda, W A; Arantes, E C

    2014-06-01

    Mature Ts1, the main neurotoxin from Tityus serrulatus venom, has its C-terminal Cys amidated, while the isolated isoform of Ts1, named Ts1-G, keeps the non-amidated Gly residue at the C-terminal region, allowing the study of the comparative functional importance of amidation at the C-terminal between these two native toxins. Voltage dependent sodium current measurements showed that the affinity of Ts1-G for sodium channels is smaller than that of the mature Ts1, confirming the important role played by the C-terminal amidation in determining Ts1 activity. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. [Construction of a system for proper TS-1 application].

    Science.gov (United States)

    Azuma, Sayaka; Morimoto, Shigefumi; Kagawa, Kunihiko; Katada, Yoshinori; Hasegawa, Kenji; Tabuse, Katsuyoshi

    2010-03-01

    TS-1 is an oral anti-tumor drug, which contains 5-chloro-2, 4-dihydroxypyridine (CDHP), a compound mainly excreted in urine. Since the CDHP concentration is increased among patients with impaired renal function, the frequency of side effects of TS-1 increases in such patients. Therefore, we constructed a computer-aided system that enables prompt monitoring of creatinine clearance (Ccr) calculated from the serum creatinine levels of patients prescribed TS-1 at the time pharmacists prepare the medicine. With this system, we found two cases who were prescribed TS-1, despite their decreased Ccr. One was a patient whose estimated Ccr was less than 30 mL/min/m2. With such renal malfunction, pharmacokinetics of the drug was considerably changed compared with normal control, and the dosage should be reduced. The other case presented with severe jaundice and had only a mild decrease of renal function (Ccr: 50 mL/min/m2). So we measured the concentration of uracil in the urine and performed a drug lymphocyte stimulation test for further investigation of concomitant affecting factors. Our system is useful because it can show pharmacists both the dosage TS-1 patients take and their renal function at a glance in real time. This system can be adapted for every medicine which might accumulate in patients with renal dysfunction.

  11. Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801.

    Science.gov (United States)

    Siddiqui, A; Lacroix, T; Stasko, M R; Scott-McKean, J J; Costa, A C S; Gardiner, K J

    2008-10-01

    Down syndrome (DS), caused by trisomy of human chromosome 21 (chr21), is the most common genetic cause of intellectual disability. The Ts65Dn mouse model of DS is trisomic for orthologs of 94 chr21-encoded, confirmed protein-coding genes and displays a number of behavioral deficits. Recently, Ts65Dn mice were shown to be hypersensitive to the locomotor stimulatory effects of the high-affinity N-methyl-d-aspartate (NMDA) receptor (NMDAR) channel blocker, MK-801. This is consistent with the functions of several chr21 proteins that are predicted directly or indirectly to impact NMDAR function or NMDAR-mediated signaling. In this study, we show that a second mouse model of DS, the Ts1Cje, which is trisomic for 70 protein-coding genes, is also hypersensitive to MK-801. To investigate the molecular basis for the responses to MK-801, we have measured levels of a subset of chr21 and phosphorylated non-chr21 proteins, in the cortex and hippocampus of Ts65Dn and Ts1Cje mice and euploid controls, with and without treatment with MK-801. We show that in euploid mice, the chr21-encoded proteins, TIAM1 and DYRK1A, and phosphorylation of AKT, ERK1/2 and the transcription factor ELK are involved in the MK-801 response. However, in both Ts65Dn and Ts1Cje mice, levels of phosphorylation are constitutively elevated in naïve, unstimulated mice, and the MK-801-induced changes in TIAM1 and DYRK1A and in phosphorylation are either absent or abnormal, with both genotype and brain-region-specific patterns. These results emphasize the complexities of the pathway perturbations that arise with segmental trisomy.

  12. Um estudo psicossocial dos significados e sentidos expressos nas músicas de MV Bill A psychosocial study of the meanings expressed in the songs of MV Bill

    Directory of Open Access Journals (Sweden)

    Jaison Hinkel

    2009-08-01

    Full Text Available Este artigo tem por propósito estudar os significados e sentidos expressos nas letras das músicas de MV Bill, um dos ícones do rap nacional, com o intuito de possibilitar a compreensão da sua tendência afetivo-volitiva. Com base na Psicologia Sócio-Histórica, a pesquisa se caracteriza como um estudo de caso e utiliza como método a análise de conteúdo de quatro músicas: "Soldado do Morro", "Só Deus pode me julgar", "EMIVI" e "Atitude Errada". Os significados e sentidos das canções estudadas denunciam as dimensões objetiva, ética e subjetiva da dialética exclusão/inclusão social, bem como a proposta de enfrentamento desta condição. Assim, podem-se considerar tais músicas como indicadores de uma práxis ético-política que propõe ações coletivas com o objetivo de superar a situação de padecimento humano e utiliza a arte como expressão afetiva de potência de vida e criação, em prol da cidadania.The purpose of this article is the analysis of meanings expressed in the song of MV Bill, one of the icons of the Brazilian rap, aiming at the comprehension of its affectionate-volitive tendency. The investigation is characterized as a case study and applies content analysis to four songs: "Soldado do Morro", "Só Deus pode me julgar", "EMIVI", and "Atitude Errada". The meanings and senses of the songs studied identify three dimensions of the dialectics social exclusion/enclosure (objective, ethical and subjective, as well as the clashing of this condition. It seems reasonable to consider such songs as indicators of an ethical-political practice that proposes collective actions with the objective of overcoming the situation of human suffering and utilizes art as affectionate expression of power of life and creation, in behalf of the citizenship.

  13. Eksperimentasi Model Pembelajaran Two Stay Two Stray (Ts-ts) Dan Think-pair-share (Tps) Dengan Pendekatan Pendidikan Matematika Realistik (Pmr) Ditinjau Dari Aktivitas Belajar Matematika

    OpenAIRE

    Pramugarini, Dwi Yuni; Kusmayadi, Tri Atmojo; Riyadi, Riyadi

    2014-01-01

    This research was aimed to find out: (1) which one gave better mathematics learning achievement, learning model TS-TS with Realistic Mathematics Education (RME) approach, TPS with RME approach or conventional learning; (2) which one had better mathematics learning achievement, students having high, medium or low mathematics learning activity; (3) in each students' levels of mathematics learning activity which one gave better mathematics learning achievement, learning model TS-TS with RME appr...

  14. Kunstisuvi 1999 / Sirje Eelma, Rait Prääts

    Index Scriptorium Estoniae

    Eelma, Sirje, 1950-

    1999-01-01

    12. juunist näitus "Rahvusvaheline väikegraafika ja eesti väikeskulptuur" Kuressaare Raegaleriis. Koostajad ja kujundajad Sirje Eelma, Terje Ojaver. 19. juunist Haapsalu Linnagaleriis ja lisaruumides väljapanek "Motiiv". Koostajad Agur Kruusing, Sirje Eelma, Rait Prääts, kujundaja Agur Kruusing. Pärnu Linnagaleriis näitus "Minimaal". Koostaja ja kujundaja Rait Prääts. Muuseumiaidas eesti noorema kunsti väljapanek "Voolab". Koostaja Karol Kallas. Juuli lõpul Selgase dolomiidipäevad Kuressaares. Pärast põhinäituste lõppemist valiknäitus Paide Vallitornis

  15. Crescimento de genótipos de frangos tipo caipira

    Directory of Open Access Journals (Sweden)

    R. C. Veloso

    2015-10-01

    Full Text Available RESUMOObjetivou-se com este trabalho comparar o padrão de crescimento, mediante ajustes das respectivas curvas de crescimento por modelos não lineares, bem como estudar o desenvolvimento de cortes de carcaça em relação ao peso da carcaça em diferentes genótipos de frangos tipo caipira. Foram utilizados 840 pintos de um dia, machos, distribuídos em delineamento inteiramente ao acaso, dos seguintes genótipos da linhagem Redbro: Caboclo, Carijó, Colorpak, Gigante Negro, Pesadão Vermelho, Pescoço Pelado e Tricolor. As aves foram alojadas em 28 boxes, sendo 30 aves/boxe, em galpão de alvenaria com acesso a um piquete de 45m², com quatro repetições. O peso corporal individual dos frangos foi medido ao nascer, aos 14, 28, 42, 56, 70 e 84 dias de idade. Para a determinação das curvas de crescimento do peso corporal das aves, os dados coletados foram avaliados por meio dos modelos não lineares: Brody, Gompertz, Logístico, Richards e von Bertalanffy. Foi empregado o PROC NLIN do SAS, utilizando-se o método interativo de Gauss-Newton. Os critérios usados para escolha do modelo de melhor ajuste da curva de crescimento foram o coeficiente de determinação, o desvio padrão assintótico, o desvio médio absoluto dos resíduos e o índice assintótico. As análises para obtenção dos coeficientes alométricos foram realizadas por meio do PROC GLM do SAS para os genótipos Carijó, Colorpak, Pesadão Vermelho, Pescoço Pelado e Tricolor. Foram avaliados os pesos da carcaça, do peito, das coxas, das sobrecoxas, das pernas e das asas das aves abatidas aos 85 dias de idade. Apenas as equações propostas por Gompertz, von Bertalanffy e Logístico atingiram a convergência, e o modelo proposto por von Bertalanffy foi o mais adequado para descrever o crescimento dos genótipos de frangos caipiras. Todos os cortes avaliados apresentaram crescimento tardio em relação ao peso da carcaça em genótipos de frangos tipo caipira.

  16. Direct Hydroxylation of Benzene to Phenol over TS-1 Catalysts

    Directory of Open Access Journals (Sweden)

    Yuecheng Luo

    2018-01-01

    Full Text Available We synthesized a TS-1 catalyst to directly hydroxylate benzene to phenol with H2O2 as oxidant and water as solvent. The samples were characterized by FT-IR (Fourier Transform Infrared, DR UV-Vis (Diffused Reflectance Ultraviolet Visible, XRD (X-ray diffraction, SEM(scanning electron microscope, TEM (Transmission Electron Microscope, XPS (X-ray photoelectron spectroscopy, ICP (inductively coupled plasma spectrum, and N2 adsorption-desorption. A desirable phenol yield of 39% with 72% selectivity was obtained under optimized conditions: 0.15 g (0.34 to the mass of benzene TS-1, 5.6 mmol C6H6, reaction time 45 min, 0.80 mL H2O2 (30%, 40.0 mL H2O, and reaction temperature 70 °C. The reuse of the TS-1 catalyst illustrated that the catalyst had a slight loss of activity resulting from slight Ti leaching from the first run and then kept stable. Almost all of the Ti species added in the preparation were successfully incorporated into the TS-1 framework, which were responsible for the good catalytic activity. Extraframework Ti species were not selective for hydroxylation.

  17. TS-05: 150 lines of java with high architectural complexity

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak

    2005-01-01

    In the short time span available in a software architecture course, it is difficult to find a software system that is both interesting from an architectural perspective and so small that it does not overwhelm the students.We present TS-05 which is a bare 150 line Java "toy-system" that never...

  18. Move of Purchasing Offices TS – AB* – AT*

    CERN Multimedia

    FI Department

    2008-01-01

    The TS – AB* - AT* Purchasing Offices and the Purchasing Pool have moved to Building 5 – 2nd and *3rd floors. The phone and fax numbers are unchanged. We apologize for any inconvenience caused by the move. Thank you for your understanding. Finance Department – Purchasing Service.

  19. Theatrical Style and the Work of T.S. Eliot.

    Science.gov (United States)

    Harris, Warren Meredith

    This study examines T.S. Eliot's intentions for the staging of his plays, as revealed in the texts themselves and in related documents. His plays reflect his basically naturalistic conception of the stage environment and the acting; two of the plays, "Sweeney Agonistes," which was unfinished, and "The Family Reunion," demonstrate his inability to…

  20. CaTs Lab (CHAOS and Thermal Sciences Laboratory)

    Science.gov (United States)

    Teate, Anthony A.

    2002-01-01

    The CHAOS and Thermal Sciences Laboratory (CaTs) at James Madison University evolved into a noteworthy effort to increase minority representation in the sciences and mathematics. Serving ten students and faculty directly, and nearly 50 students indirectly, CaTs, through recruitment efforts, workshops, mentoring programs, tutorial services and research and computational laboratories, fulfilled its intent to initiate an academically enriched research program aimed at strengthening the academic and self-actualization skills of undergraduate students with potential to pursue doctoral study in the sciences. The stated goal of the program was to increase by 5% the number of enrolled mathematics and science students into the program. Success far exceeded the program goals by producing 100% graduation rate of all supported recipients during its tenure, with 30% of the students subsequently in pursuit of graduate degrees. Student retention in the program exceeded 90% and faculty participation exceeded the three members involved in mentoring and tutoring, gaining multi-disciplinary support. Aggressive marketing of the program resulted in several paid summer internships and commitments from NASA and an ongoing relationship with CHROME, a nationally recognized organization which focuses on developing minority students in the sciences and mathematics. Success of the program was only limited by the limited fiscal resources at NASA which resulted in phasing out of the program.

  1. Olhar como os pssaros. Sobre a estrutura de enunciao de um tipo de mapa cartogrfico To look like the birds: about the enunciation structure present on a kind of cartographic map

    Directory of Open Access Journals (Sweden)

    Felix Thrlemann

    2012-01-01

    Full Text Available Alguns estudiosos das cincias humanas se interessaram por estudar textos visuais no valorizados pela grande arte. Esse recente interesse pelas imagens que no se enquadram na disciplina da histria da arte reflete o crescente papel que desempenha a visualidade atualmente. Seguindo os passos de Algirdas Julien Greimas, que sempre incentivou os estudos nos diferentes domnios da expresso visual independentemente da substncia da expresso implicada, escolhemos como objeto de anlise um gnero de texto visual extra-esttico - um mapa cartogrfico - com o intuito de estudar como se estrutura a enunciao de um tipo particular de mapa, o chamado vista voo de pssaro.Some human sciences researchers are interested on studying visual texts that are not valorized by the great art. This recent interest for images that are not framed by art history discipline reflect the upgrowing role that visuality plays nowadays. According to the steps of Algirdas Julien Greimas, that has always encouraged the studies on different domains of visual expression - regardless the implied expressions substance - we have chosen as an object of analysis a textual genre extra-aesthetical - a cartographic map - with the intention of studying how can be structured the enunciation of a particular type of map called view like a birds flight.

  2. CATALYTIC PERFORMANCES OF Fe2O3/TS-1 CATALYST IN PHENOL HYDROXYLATION REACTION

    Directory of Open Access Journals (Sweden)

    Didik Prasetyoko

    2010-07-01

    Full Text Available Hydroxylation reaction of phenol into diphenol, such as hydroquinone and catechol, has a great role in many industrial applications. Phenol hydroxylation reaction can be carried out using Titanium Silicalite-1 (TS-1 as catalyst and H2O2 as an oxidant. TS-1 catalyst shows high activity and selectivity for phenol hydroxylation reaction. However, its hydrophobic sites lead to slow H2O2 adsorption toward the active site of TS-1. Consequently, the reaction rate of phenol hydroxylation reaction is tends to be low. Addition of metal oxide Fe2O3 enhanced hydrophilicity of TS-1 catalyst. Liquid phase catalytic phenol hydroxylation using hydrogen peroxide as oxidant was carried out over iron (III oxide-modified TS-1 catalyst (Fe2O3/TS-1, that were prepared by impregnation method using iron (III nitrate as precursor and characterized by X-ray diffraction, infrared spectroscopy, nitrogen adsorption, pyridine adsorption, and hydrophilicity techniques. Catalysts 1Fe2O3/TS-1 showed maximum catalytic activity of hydroquinone product. In this research, the increase of hydroquinone formation rate is due to the higher hydrophilicity of Fe2O3/TS-1 catalysts compare to the parent catalyst, TS-1.   Keywords: Fe2O3/TS-1, hydrophilic site, phenol hydroxylation

  3. LIDAR TS for ITER core plasma. Part I: layout & hardware

    Science.gov (United States)

    Salzmann, H.; Gowers, C.; Nielsen, P.

    2017-12-01

    The original time-of-flight design of the Thomson scattering diagnostic for the ITER core plasma has been shown up by ITER. This decision was justified by insufficiencies of some of the components. In this paper we show that with available, present day technology a LIDAR TS system is feasible which meets all the ITER specifications. As opposed to the conventional TS system the LIDAR TS also measures the high field side of the plasma. The optical layout of the front end has been changed only little in comparison with the latest one considered by ITER. The main change is that it offers an optical collection without any vignetting over the low field side. The throughput of the system is defined only by the size and the angle of acceptance of the detectors. This, in combination with the fact that the LIDAR system uses only one set of spectral channels for the whole line of sight, means that no absolute calibration using Raman or Rayleigh scattering from a non-hydrogen isotope gas fill of the vessel is needed. Alignment of the system is easy since the collection optics view the footprint of the laser on the inner wall. In the described design we use, simultaneously, two different wavelength pulses from a Nd:YAG laser system. Its fundamental wavelength ensures measurements of 2 keV up to more than 40 keV, whereas the injection of the second harmonic enables measurements of low temperatures. As it is the purpose of this paper to show the technological feasibility of the LIDAR system, the hardware is considered in Part I of the paper. In Part II we demonstrate by numerical simulations that the accuracy of the measurements as required by ITER is maintained throughout the given plasma parameter range. The effect of enhanced background radiation in the wavelength range 400 nm-500 nm is considered. In Part III the recovery of calibration in case of changing spectral transmission of the front end is treated. We also investigate how to improve the spatial resolution at the

  4. Positron identification by TRDs in TS93 and PAMELA experiments

    International Nuclear Information System (INIS)

    Bellotti, R.; Cafagna, F.; Castellano, M.; Circella, M.; De Marzo, C.; De Cataldo, G.; Giglietto, N.; Marangelli, B.; Raino, A.; Spinelli, P.

    1997-01-01

    We are involved in a program to study the antimatter components of the cosmic rays in outer space. We present the performances of a transition radiation detector we have built for positron identification during a balloon flight in 1993. The flight (TS93) was dedicated to the measurement of the positron spectrum in the energy range 4-50 GeV. We present also the design and expected performances of a similar detector we intend to build for a future experiment (PAMELA), to be run on a satellite by the end of 1999, in order to complete this program with higher statistics and at higher energies, namely about 200 GeV. (orig.)

  5. Intermittent magnetic reconnection in TS-3 merging experiment

    International Nuclear Information System (INIS)

    Ono, Y.; Hayashi, Y.; Ii, T.; Tanabe, H.; Ito, S.; Kuwahata, A.; Ito, T.; Kamino, Y.; Yamada, T.; Inomoto, M.

    2011-01-01

    Ejection of current sheet with plasma mass causes impulsive and intermittent magnetic reconnection in the TS-3 spherical tokamak (ST) merging experiment. Under high guide toroidal field, the sheet resistivity is almost classical due to the sheet thickness much longer than the ion gyroradius. Large inflow flux and low current-sheet resistivity result in flux and plasma pileup followed by rapid growth of the current sheet. When the pileup exceeds a critical limit, the sheet is ejected mechanically from the squeezed X-point area. The reconnection (outflow) speed is slow during the flux/plasma pileup and is fast during the ejection, suggesting that intermittent reconnection similar to the solar flare increases the averaged reconnection speed. These transient effects enable the merging tokamaks to have the fast reconnection as well as the high-power reconnection heating, even when their current-sheet resistivity is low under high guide field.

  6. REAC/TS Radiation Accident Registry: An Overview

    Energy Technology Data Exchange (ETDEWEB)

    Doran M. Christensen, DO, REAC/TS Associate Director and Staff Physician Becky Murdock, REAC/TS Registry and Health Physics Technician

    2012-12-12

    Over the past four years, REAC/TS has presented a number of case reports from its Radiation Accident Registry. Victims of radiological or nuclear incidents must meet certain dose criteria for an incident to be categorized as an “accident” and be included in the registry. Although the greatest numbers of “accidents” in the United States that have been entered into the registry involve radiation devices, the greater percentage of serious accidents have involved sealed sources of one kind or another. But if one looks at the kinds of accident scenarios that have resulted in extreme consequence, i.e., death, the greater share of deaths has occurred in medical settings.

  7. Composite repairs qualification according to ISO/TS 24817

    Energy Technology Data Exchange (ETDEWEB)

    Meniconi, Luiz C.M.; Perrut, Valber A. [Petroleo Brasileiro S.A. (PETROBRAS/CENPES), Rio de Janeiro, RJ (Brazil). Centro de Pesquisas

    2009-07-01

    Composite repairs for metallic pipes from three different suppliers were evaluated according to ISO Technical Specification TS 24817. The intended application scenarios are offshore production plants, but the design methodology is also applicable to onshore pipelines and pipework. The evaluation covered all the relevant mechanical properties and established the maximum application temperatures for each repair system. The tests also considered the application of composite repair sleeves to metallic pipes with through thickness defects, by measuring the strain energy release rates of the composite-metal interfaces. The test campaigns aimed to verify the applicability of the recently published ISO document, and to implement it as the routine procedure for composite repairs evaluation within PETROBRAS. The tests also addressed the influence of metallic pipe surface preparation on the final properties of the repair sleeves, especially in relation to the long term behavior of leaking pipes repaired by means of composite materials. (author)

  8. ISO/TS 16949 system in quality aspect

    Directory of Open Access Journals (Sweden)

    Joanna Rosak-Szyrocka

    2014-12-01

    Full Text Available In the automotive industry the use of modern technology and provision of the highest quality product and related services is the most important element of rivalry between global corporations and motorcycles. In a competitive struggle for the recognition of its brand in the automotive market global organizations continuously raise the requirements for quality management systems, so that the finished product meets all the standards in terms of safety, quality and satisfying the ever-growing needs of customers - present and future drivers and passengers of cars. ISO/TS 16949 quality management system is presented in the paper. A framework for customer specific requirement as well as preventing problems is shown.

  9. Comparative genomic analysis reveals a novel mitochondrial isoform of human rTS protein and unusual phylogenetic distribution of the rTS gene

    Directory of Open Access Journals (Sweden)

    McGuire John J

    2005-09-01

    Full Text Available Abstract Background The rTS gene (ENOSF1, first identified in Homo sapiens as a gene complementary to the thymidylate synthase (TYMS mRNA, is known to encode two protein isoforms, rTSα and rTSβ. The rTSβ isoform appears to be an enzyme responsible for the synthesis of signaling molecules involved in the down-regulation of thymidylate synthase, but the exact cellular functions of rTS genes are largely unknown. Results Through comparative genomic sequence analysis, we predicted the existence of a novel protein isoform, rTS, which has a 27 residue longer N-terminus by virtue of utilizing an alternative start codon located upstream of the start codon in rTSβ. We observed that a similar extended N-terminus could be predicted in all rTS genes for which genomic sequences are available and the extended regions are conserved from bacteria to human. Therefore, we reasoned that the protein with the extended N-terminus might represent an ancestral form of the rTS protein. Sequence analysis strongly predicts a mitochondrial signal sequence in the extended N-terminal of human rTSγ, which is absent in rTSβ. We confirmed the existence of rTS in human mitochondria experimentally by demonstrating the presence of both rTSγ and rTSβ proteins in mitochondria isolated by subcellular fractionation. In addition, our comprehensive analysis of rTS orthologous sequences reveals an unusual phylogenetic distribution of this gene, which suggests the occurrence of one or more horizontal gene transfer events. Conclusion The presence of two rTS isoforms in mitochondria suggests that the rTS signaling pathway may be active within mitochondria. Our report also presents an example of identifying novel protein isoforms and for improving gene annotation through comparative genomic analysis.

  10. Caracterização de genes diferencialmente expressos na interação entre maçã 'Fuji' e Botryosphaeria dothidea Characterization of differently expressed genes during the interaction between 'Fuji' apples and Botryosphaeria dothidea

    Directory of Open Access Journals (Sweden)

    Adriana Regina Corrent

    2009-03-01

    Full Text Available O objetivo deste estudo foi investigar a interação entre o fungo Botryosphaeria dothidea e maçãs cv. Fuji por meio da técnica de Differential Display RT-PCR. O cDNA de frutos infectados e não infectados pelo fungo foi amplificado com uma combinação de 15 oligonucleotídeos iniciadores. Foram isolados 400 fragmentos de cDNA diferencialmente expressos, dos quais 120 foram sequenciados e comparados com sequências disponíveis no GenBank, por meio do programa BLASTX. As sequências obtidas foram similares à metalotioninas, profilina alergênica, proteína de resistência e fosfatase.The aim of this study was to investigate the interaction between the Botryosphaeria dothidea fungi and 'Fuji' apples using the Differential Display RT-PCR technique. The cDNA of infected and non infected fruits by the fungus was amplified using a combination of 15 primers. Four hundred fragments of differentially expressed cDNA were isolated, and 120 of them were sequenced and compared with available sequences at GenBank database, using BLASTX software. Obtained sequences were similar to methalothionines, an allergenic profiline, a resistance linked protein, and a phosphatase.

  11. Precursor effect on the property and catalytic behavior of Fe-TS-1 in butadiene epoxidation

    Science.gov (United States)

    Wu, Mei; Zhao, Huahua; Yang, Jian; Zhao, Jun; Song, Huanling; Chou, Lingjun

    2017-11-01

    The effect of iron precursor on the property and catalytic behavior of iron modified titanium silicalite molecular sieve (Fe-TS-1) catalysts in butadiene selective epoxidation has been studied. Three Fe-TS-1 catalysts were prepared, using iron nitrate, iron chloride and iron sulfate as precursors, which played an important role in adjusting the textural properties and chemical states of TS-1. Of the prepared Fe-TS-1 catalysts, those modified by iron nitrate (FN-TS-1) exhibited a significant enhanced performance in butadiene selective epoxidation compared to those derived from iron sulfate (FS-TS-1) or iron chloride (FC-TS-1) precursors. To obtain a deep understanding of their structure-performance relationship, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Temperature programmed desorption of NH3 (NH3-TPD), Diffuse reflectance UV-Vis spectra (DR UV-Vis), Fourier transformed infrared spectra (FT-IR) and thermal gravimetric analysis (TGA) were conducted to characterize Fe-TS-1 catalysts. Experimental results indicated that textural structures and acid sites of modified catalysts as well as the type of Fe species influenced by the precursors were all responsible for the activity and product distribution.

  12. A virtual computing infrastructure for TS-CV SCADA systems

    CERN Document Server

    Poulsen, S

    2008-01-01

    In modern data centres, it is an emerging trend to operate and manage computers as software components or logical resources and not as physical machines. This technique is known as â€ワvirtualisation” and the new computers are referred to as â€ワvirtual machines” (VMs). Multiple VMs can be consolidated on a single hardware platform and managed in ways that are not possible with physical machines. However, this is not yet widely practiced for control system deployment. In TS-CV, a collection of VMs or a â€ワvirtual infrastructure” is installed since 2005 for SCADA systems, PLC program development, and alarm transmission. This makes it possible to consolidate distributed, heterogeneous operating systems and applications on a limited number of standardised high-performance servers in the Central Control Room (CCR). More generally, virtualisation assists in offering continuous computing services for controls and maintaining performance and assuring quality. Implementing our systems in a vi...

  13. Ceļa servitūts

    OpenAIRE

    Livdāns, Dāvis

    2016-01-01

    Bakalaura darba tēma ir “Ceļa servitūts.” Bakalaura darba mērķis ir izpētīt ceļa servitūta nodibināšanas kārtību, iespējamās kļūdas, praksē nodibināto servitūtu problēmjautājumus un to risinājumus. Bakalaura darba tapšanas stadijā autors izmantoja zinātnisko literatūru, normatīvos aktus, kā arīi ar to tapšanu saistītos dokumentus un juridiskās prakses materiālus. Darbā ir apskatīti gan Civillikumā noteiktie servitūtu nodibināšanas pamati, gan citi iespējamie nodibināšanas pamati, pēc kā ir an...

  14. Evaluation of the egg transmission and pathogenicity of Mycoplasma gallisepticum isolates genotyped as ts-11.

    Science.gov (United States)

    Armour, Natalie K; Ferguson-Noel, Naola

    2015-01-01

    Live Mycoplasma gallisepticum vaccines are used for the control of respiratory disease, egg production losses and egg transmission associated with M. gallisepticum infection in long-lived poultry. The first field case of apparent increased virulence and vertical transmission of ts-11, a live M. gallisepticum vaccine, has been reported. In that study a M. gallisepticum isolate from the broiler progeny of ts-11-vaccinated breeders was genotyped as ts-11 by sequence analysis of four different genetic targets and Random Amplified Polymorphic DNA and found to be significantly more virulent than ts-11 vaccine. The objective of the current study was to evaluate the rate of egg transmission and pathogenicity of ts-11 vaccine and isolates recovered from ts-11-vaccinated breeders (K6222B) and their broiler progeny (K6216D) which had been genotyped as ts-11. Groups of 28-week-old specific pathogen-free chickens at 87% average weekly egg production were inoculated with sterile broth media (negative controls), ts-11 vaccine, K6222B, K6216D or R strain (positive controls) by eye-drop and aerosol. K6216D transmitted via the egg at an average rate of 4.0% in the third and fourth weeks post-infection, while egg transmission of K6222B and ts-11 vaccine was not detected. M. gallisepticum was isolated from the air sacs, ovaries and oviducts of hens infected with K6216D and K6222B, but not from those infected with ts-11 vaccine. K6216D and K6222B both induced respiratory signs and significantly more tracheal colonization and more severe tracheal and air sac lesions than ts-11 vaccine (P ≤ 0.05). There were no substantial differences in the egg production of ts-11, K6216D and K6222B infected groups. These results provide the first conclusive evidence of transovarian transmission of an isolate genotyped as ts-11 and indicate that isolates genotyed as ts-11 vary in their virulence and ability to transmit via the egg.

  15. Adaptive Control of MEMS Gyroscope Based on T-S Fuzzy Model

    Directory of Open Access Journals (Sweden)

    Yunmei Fang

    2015-01-01

    Full Text Available A multi-input multioutput (MIMO Takagi-Sugeno (T-S fuzzy model is built on the basis of a nonlinear model of MEMS gyroscope. A reference model is adjusted so that a local linear state feedback controller could be designed for each T-S fuzzy submodel based on a parallel distributed compensation (PDC method. A parameter estimation scheme for updating the parameters of the T-S fuzzy models is designed and analyzed based on the Lyapunov theory. A new adaptive law can be selected to be the former adaptive law plus a nonnegative in variable to guarantee that the derivative of the Lyapunov function is smaller than zero. The controller output is implemented on the nonlinear model and T-S fuzzy model, respectively, for the purpose of comparison. Numerical simulations are investigated to verify the effectiveness of the proposed control scheme and the correctness of the T-S fuzzy model.

  16. Arquétipos da dualidade feminina no conto “Desenredo” de João Guimarães Rosa = Archetypes of feminine dualism in the short-story “Desenredo” by João Guimarães Rosa

    Directory of Open Access Journals (Sweden)

    Silva, Antonia Marly Moura da

    2012-01-01

    Full Text Available No conto “Desenredo”, integrante de Tutaméia (1967 de João Guimarães Rosa, os arquétipos da dualidade feminina emblematizam os atributos do posicionamento da mulher frente ao mundo. Adúltera, a personagem central é a Bruxa, a Grande prostituta, Lilith, encarnando a alma bacante, o protótipo dionisíaco, porém, no desfecho da narrativa, de forma mágica o amante consegue recompor aos olhos dos outros a imagem da mulher, temida e odiada pelos moradores do lugar. Reintegrando o arquétipo da Grande Mãe, a personagem passa a ser retratada como a Virgem, o arquétipo de Eva, representando a perfeição e a pureza: metas da aspiração masculina reconhecidas pela tradição de Eros. É, pois, seguindo essa linha de reflexão que faremos uma leitura do referido conto procurando reconhecer símbolos e arquétipos da dualidade expressos na arquitetura ficcional

  17. Scientific Communication for Positive Action: Do's and Don'ts

    Science.gov (United States)

    Sanquini, A.; Wood, M. M.

    2015-12-01

    Natural hazard presentations often highlight disasters that may ensue from natural processes when mitigation or preparedness actions are not taken. Examples include images of raging fires, collapsed buildings, and flooded urban areas. Research has shown that this makes presentations more interesting and more memorable. Such images are the stock and trade of disaster reporting by the media. Unfortunately, it may also trigger avoidance and denial in the audience, resulting in preparedness reduction; the opposite effect of what may have been intended by the speaker. Recent social research has provided insight into a better approach. The theory of communicating actionable risk posits that people will take action against hazards when they know what to do, think it would work, and know someone who did it. This approach was recently applied in an intervention designed to motivate earthquake-resistant construction in Kathmandu Valley, Nepal. Social theory further suggests that a tendency towards action is strengthened by hearing a consistent message over time, and by providing the audience with an appropriate opportunity to seek out relevant information. This presentation shows how, by taking this transdisciplinary step, scientists can make small changes in their hazard communication, thereby acting as positive influencers of change. A summary of "do's" and "don'ts" is given for reference. 1. Show examples of what to do. 2. Show effectiveness of actions. 3. Give sense of knowing someone who did it. 4. Deliver consistent message, repeatedly. 5. Give opportunity for more information. DON'T: 1. Make the disaster the star. 2. Contradict other communications.

  18. Tegafur/gimeracil/oteracil (TS-1 induced Stevens–Johnson syndrome: Case report

    Directory of Open Access Journals (Sweden)

    Satoko Minakawa

    2013-09-01

    Full Text Available TS-1 is an oral fluoropyrimidine anticancer drug that contains tegafur, gimeracil, and oteracil. A 78-year-old Japanese male who was diagnosed with carcinoma of the oral floor (rT4aN0M0 was prescribed a standard dose of TS-1 (80 mg/day. On Day 8 after administration of TS-1, an eruption developed. There was erythema, along with vesicles and erosions involving the lip, face, neck, trunk, limbs, and genitals. The drug-induced lymphocyte stimulation test (DLST for TS-1 was negative on the 23rd day, but positive on the 43rd day (20 days after discontinuing prednisolone. The condition was diagnosed as Stevens–Johnson syndrome due to TS-1 because of the clinical course and laboratory results. This case and 24 cases previously reported in the literature were analyzed. The types of drug eruption were drug-related lupus (9 cases, acral erythema (7 cases, scleroderma-like skin lesion (2 cases, Stevens–Johnson syndrome (2 cases, lichenoid eruption (1 case, purpura (1 case, lichen planus (1 case, erythema multiforme (1 case, hypopigmentation (1 case and toxic epidermal necrolysis (1 case, respectively. In view of the increasing usage of TS-1 in several common cancers, clinicians should be aware of drug eruptions due to TS-1.

  19. Field Support System (FS-AID) and Working Capital Fund Tracking System (WCF-TS)

    Data.gov (United States)

    US Agency for International Development — The Field Support System (FS-AID) and Working Capital Fund Tracking System (WCF-TS) are two modules of a single data management system that share common tables and...

  20. 3Ts for Reducing Lead in Drinking Water in Schools and Child Care Facilities

    Science.gov (United States)

    EPA’s 3Ts was developed to assist schools with lead in drinking water prevention programs. It is intended for use by school officials responsible for the maintenance and/or safety of school’s drinking water.

  1. Tipos de tricomas em genótipos de Lycopersicon Types of trichomes in Lycopersicon genotypes

    Directory of Open Access Journals (Sweden)

    Luciana C. Toscano

    2001-11-01

    Full Text Available Foram identificados os tipos de tricomas em alguns genótipos de Lycopersicon, utilizando microscópio eletrônico de varredura. Foram utilizados os genótipos L. hirsutum (PI 127826 e PI 127827, L. hirsutum var. glabratum (PI 134417, L. pennellii (LA 716 e L. esculentum (híbrido Bruna VFN e Santa Clara. Os tricomas glandulares encontrados foram tipo IV em LA 716, PI 127826, PI 127827 e PI 134417; tipo VIc em PI 127826, PI 127827, PI 134417 e Santa Clara; tipo VII em PI 127826, PI 127827 e PI 134417; tipo I em PI 127826, PI 127827, PI 134417, híbrido Bruna VFN e Santa Clara; tipo VIa em híbrido Bruna VFN. Os tricomas não glandulares observados foram: tipo Va em PI 127826, PI 127827, PI 134417, híbrido Bruna VFN e Santa Clara; VIII em híbrido Bruna VNF e os tipos III e Vb em Santa Clara.The types of trichomes in some Lycopersicon genotypes were identified using the scanning electron microscope. The tomato genotypes observed were L. hirsutum (PI 127826 and PI 127827, L. hirsutum f. glabratum (PI 134417, L. pennellii (LA 716 and L. esculentum (Bruna VFN hybrid and Santa Clara. The following glandular trichomes were found: type IV in LA 716, PI 127826, PI 127827 and PI 134417; type VIc in PI 127826, PI 127827, PI 134417 and Santa Clara; type VII in PI 127826, PI 127827 and PI 134417; type I in PI 127826, PI 127827, PI 134417 , Bruna VFN hybrid and Santa Clara; type VIa in Bruna VFN hybrid. The following nonglandular trichomes were observed: type Va in PI 127826, PI 127827, PI 134417, Bruna VFN Hybrid and Santa Clara; type VIII in Bruna VNF hybrid and types III and Vb in Santa Clara.

  2. Catarata e diabetes mellitus tipo 1

    OpenAIRE

    Pizzol,Melissa Manfroi Dal; Esteves,Jorge Freita; Sccoco,Caio Augusto; Roggia,Murilo Felix; Rosa,Carolina Maurente da; Lambert,José Humberto Franco; Canani,Luís Henrique

    2008-01-01

    OBJETIVO: Avaliar a prevalência de catarata e seus fatores de risco em uma população portadora de diabetes mellitus tipo 1 (DM1). MÉTODOS: Estudo de casos e controles de um banco de dados de 181 pacientes (362 olhos) com diagnóstico de diabetes mellitus tipo 1. Os pacientes foram classificados como casos quando apresentavam diagnóstico de catarata. As variáveis estudadas foram a presença ou não de retinopatia diabética, tratamento com panfotocoagulação, presença de hipertensão arterial sistêm...

  3. Algunos tipos de preferencias no transitivas

    OpenAIRE

    Carmen Vázquez

    2010-01-01

    Este trabajo ofrece una visión sobre la modelación de las relaciones de preferencias del consumidor diferente a la clásica, pues prescindimos de la hipótesis de transitividad. Concretamente, analizamos dos tipos de relaciones de preferencias no transitivas, las acíclicas y las asimétricas, que bajo ciertas condiciones, admiten tipos de representación numérica distintos. Justificamos la aceptación de las mismas mediante ejemplos prácticos y vemos también resultados que garantizan la existencia...

  4. Konstantin Päts ja NSV Liidu Tallinna saatkond / Magnus Ilmjärv

    Index Scriptorium Estoniae

    Ilmjärv, Magnus, 1961-

    1999-01-01

    Järg Sep/13,14,15,16,17,18,20,21,22,22 lk. 17,21,17,18,18,16,17,21,18,14. Päts kui Nõukogude saatkonna lobitegija. Välisminister Pusta kangutamine. Pätsi info venelastele J. Tõnissoni kohta. Balti riikide vahelise koostöö takistamine. J. Puhk tõmmati venelaste mõjusfääri. Päts nõuab Eesti valitsuselt uut kaubanduslepingut venelastega

  5. Advanced high temperature superconductor film-based process using RABiTS

    International Nuclear Information System (INIS)

    Goyal, A.; Hawsey, R.A.; Hack, J.; Moon, D.

    2000-01-01

    The purpose of this Cooperative Research and Development Agreement (CRADA) between Lockheed Martin Energy Research Corporation (Contractor), Managing contractor for Oak Ridge National Laboratory (ORNL) and Midwest Superconductivity, Inc. (MSI) and Westinghouse Science and Electric Company (WEC) was to develop the basis for a commercial process for the manufacturing of superconducting tape based on the RABiTS technology developed at ORNL. The chosen method for deposition of YBCO films on RABiTS was Metal Organic chemical Vapor Deposition (MOCVD)

  6. Impôts, taxes et équité entre les sexes : codes, comportements et ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    6 déc. 2010 ... La discrimination fondée sur le sexe est une des facettes des inégalités. On sait que les impôts et la taxation peuvent favoriser l'égalité socioéconomique, mais leurs répercussions sur les disparités entre les sexes demeurent peu connues. Les impôts et les taxes les accentuent-ils ? Les codes fiscaux ...

  7. Computer Programs for LB/TS Test Design: Technical Description, Usage Instructions and Source Code Listings

    Science.gov (United States)

    1995-09-01

    this subprogram defines the relationship bet~een the ·actuator position c louver angle and open area for the end vend of the LB /TS RWE c c...ARMY RESEARCH UBORA TORY Computer Programs for LB {fS Test Design: Technical Description, Usage Instructions and Source Code Listings ARL-MR-260...COVERED Final, Oct 94 - May 95 4. TITLE AND SUBTITLE 5. FUNDING NUMBERS Computer Programs for LB /TS Test Design: Technical Description, Usage

  8. T-S Fuzzy Modelling and H∞ Attitude Control for Hypersonic Gliding Vehicles

    Directory of Open Access Journals (Sweden)

    Weidong Zhang

    2017-01-01

    Full Text Available This paper addresses the T-S fuzzy modelling and H∞ attitude control in three channels for hypersonic gliding vehicles (HGVs. First, the control-oriented affine nonlinear model has been established which is transformed from the reentry dynamics. Then, based on Taylor’s expansion approach and the fuzzy linearization approach, the homogeneous T-S local modelling technique for HGVs is proposed. Given the approximation accuracy and controller design complexity, appropriate fuzzy premise variables and operating points of interest are selected to construct the T-S homogeneous submodels. With so-called fuzzy blending, the original plant is transformed into the overall T-S fuzzy model with disturbance. By utilizing Lyapunov functional approach, a state feedback fuzzy controller has been designed based on relaxed linear matrix inequality (LMI conditions to stable the original plants with a prescribed H∞ performance of disturbance. Finally, numerical simulations are performed to demonstrate the effectiveness of the proposed H∞ T-S fuzzy controller for the original attitude dynamics; the superiority of the designed T-S fuzzy controller compared with other local controllers based on the constructed fuzzy model is shown as well.

  9. Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response.

    Science.gov (United States)

    Luo, Shiqi; He, Feng; Luo, Junjie; Dou, Shengqian; Wang, Yirong; Guo, Annan; Lu, Jian

    2018-03-14

    Transfer RNA-derived small RNAs (tsRNAs) are an emerging class of small RNAs, yet their regulatory roles have not been well understood. Here we studied the molecular mechanisms and consequences of tsRNA-mediated regulation in Drosophila. By analyzing 495 public small RNA libraries, we demonstrate that most tsRNAs are conserved, prevalent and abundant in Drosophila. By carrying out mRNA sequencing and ribosome profiling of S2 cells transfected with single-stranded tsRNA mimics and mocks, we show that tsRNAs recognize target mRNAs through conserved complementary sequence matching and suppress target genes by translational inhibition. The target prediction suggests that tsRNAs preferentially suppress translation of the key components of the general translation machinery, which explains how tsRNAs inhibit the global mRNA translation. Serum starvation experiments confirm tsRNAs participate in cellular starvation responses by preferential targeting the ribosomal proteins and translational initiation or elongation factors. Knock-down of AGO2 in S2 cells under normal and starved conditions reveals a dependence of the tsRNA-mediated regulation on AGO2. We also validated the repressive effects of representative tsRNAs on cellular global translation and specific targets with luciferase reporter assays. Our study suggests the tsRNA-mediated regulation might be crucial for the energy homeostasis and the metabolic adaptation in the cellular systems.

  10. T11TS repress gliomagenic apoptosis of bone marrow hematopoietic stem cells.

    Science.gov (United States)

    Mondal, Somnath; Hazra, Iman; Datta, Ankur; Sk Md, Omar Faruk; Moitra, Saibal; Tripathi, Santanu Kumar; Chaudhuri, Swapna

    2018-01-01

    Combating gliomagenic global immunosuppression is one of the emerging key for improving prognosis in malignant glioma. Apoptosis plays a pivotal role within the adult hematopoietic system particularly in regulating the cells of immune system. Gliomagenic regulation of apoptotic mediators within bone marrow milieu has not been elucidated. We previously demonstrated that administration of membrane glycopeptides T11 target structure (T11TS) not only rejuvenate bone marrow hematopoietic stem cells (BMHSCs) from glioma mediated hibernation by inhibiting gliomagenic overexpression of Ang-1/Tie-2 but also stimulate glioma mediated diminution of expression CD34, c-kit, and Sca-1 markers. In the present study, we investigated the impact of glioma on apoptotic signaling cascades of BMHSCs and consequences following T11TS therapy. Bone marrow smear and Annexin V staining confirm gliomagenic acceleration of apoptotic fate of BMHSCs whereas T11TS treatment in glioma-bearing rats disrupted apoptosis of BMHSCs. Flowcytometry, immunoblotting, and immunofluorescence imagining results revealed multi potent T11TS not only significantly downregulates gliomagenic overexpression of Fas, Fas L, Bid, and caspase-8, the pro-apoptotic extrinsic mediators but also strongly inhibits cytosolic release of cytochrome-c, Apf-1, and Bax to deactivate gliomagenic caspase-9, 3 the key intrinsic apoptotic mediators followed by up modulation of anti-apoptotic Bcl-2 in glioma associated HSCs. T11TS is also able to diminish the perforin-granzyme B mediated apoptotic verdict of BMHSCs during gliomagenesis. The anti-apoptotic action of T11TS on glioma associated BMHSCs provide a crucial insight into how T11TS exerts its immunomodulatory action against glioma mediated immune devastation. © 2017 Wiley Periodicals, Inc.

  11. Neodesarrollismo y el tipo de cambio competitivo

    Directory of Open Access Journals (Sweden)

    Alejandro Fiorito

    2015-01-01

    Full Text Available En este trabajo se intenta mostrar que las modificaciones en los tipos de cambio tienen efectos limitados en el aumento del producto, mientras que, inversamente, esos cambios impactan especialmente en la distribución del ingreso al incidir en los precios domésticos. Se analizan y muestran múltiples referencias de la literatura internacional que cuestionan este "consenso de tipos de cambio competitivos". Se realizan correlaciones que muestran resultados distintos de los obtenidos en Rodrik (2008 con los mismos datos utilizados, aunque simplemente cambiando la metodología de datos de panel y usando en cambio una más convencional de series de tiempo.

  12. Tipos e mitos do pensamento brasileiro

    Directory of Open Access Journals (Sweden)

    Ianni Octavio

    2002-01-01

    Full Text Available No pensamento brasileiro são freqüentes os "tipos ideais" elaborados por diferentes autores e que se tornam emblemáticos, notáveis ou mesmo definitivos, podendo, às vezes, figurar como mitos. Esse é o caso do bandeirante, do gaúcho, do Jeca Tatu, do Macunaíma, do homem cordial e outros. Vale a pena refletir sobre este aspecto da cultura e do pensamento brasileiros.

  13. Robust Stabilization of T-S Fuzzy Stochastic Descriptor Systems via Integral Sliding Modes.

    Science.gov (United States)

    Li, Jinghao; Zhang, Qingling; Yan, Xing-Gang; Spurgeon, Sarah K

    2017-09-19

    This paper addresses the robust stabilization problem for T-S fuzzy stochastic descriptor systems using an integral sliding mode control paradigm. A classical integral sliding mode control scheme and a nonparallel distributed compensation (Non-PDC) integral sliding mode control scheme are presented. It is shown that two restrictive assumptions previously adopted developing sliding mode controllers for Takagi-Sugeno (T-S) fuzzy stochastic systems are not required with the proposed framework. A unified framework for sliding mode control of T-S fuzzy systems is formulated. The proposed Non-PDC integral sliding mode control scheme encompasses existing schemes when the previously imposed assumptions hold. Stability of the sliding motion is analyzed and the sliding mode controller is parameterized in terms of the solutions of a set of linear matrix inequalities which facilitates design. The methodology is applied to an inverted pendulum model to validate the effectiveness of the results presented.

  14. T.S. ELIOT'S MISREADING OF SOME LITERARY SOURCES IN THE WASTE LAND

    Directory of Open Access Journals (Sweden)

    Liem Satya Limanta

    2002-01-01

    Full Text Available A poet cannot be a poet at all if he is not connected with all the poetic tradition before him. This is T.S. Eliot's dictum which he stated in Tradition and the Individual Talent and which he practiced in his work The Waste Land. T.S. Eliot showed his relationship with the past through all the quotations and allusions to mythical, literary, and religious works. His reading of those sources according to Paul de Man cannot avoid misreading or misinterpretation. Harold Bloom has tried to build up a theory of misreading, which he prefers to call misprision, especially applied to and done by poets in The Anxiety of Influence. Throughout this article I shall show how T.S. Eliot has applied some of the ways Bloom describes in reading some of the literary sources, and by so doing Eliot has given new meaning to them.

  15. Ataxia espinocerebelar tipo 6: relato de caso

    Directory of Open Access Journals (Sweden)

    Bianca Simone Zeigelboim

    2014-10-01

    Full Text Available O objetivo deste estudo foi verificar as alterações vestibulococleares observadas em um caso de ataxia espinocerebelar tipo 6. O caso foi encaminhado do Hospital de Clínicas para o Laboratório de Otoneurologia de uma Instituição de Ensino e foi submetido aos seguintes procedimentos: anamnese, inspeção otológica, avaliações audiológica e vestibular. O caso retrata uma paciente com diagnóstico genético de ataxia espinocerebelar tipo 6, do sexo feminino, com 57 anos de idade, que referiu desequilíbrio à marcha com tendência a queda para a esquerda, disartria e disfonia. Na avaliação audiológica apresentou configuração audiométrica descendente a partir da frequência de 4kHz e curva timpanométrica do tipo "A" com presença dos reflexos estapedianos bilateralmente. No exame vestibular observou-se na pesquisa da vertigem posicional presença de nistagmo vertical inferior e oblíquo, espontâneo e semiespontâneo múltiplo com características centrais (ausência de latência, paroxismo, fatigabilidade e vertigem, nistagmooptocinético abolido e hiporreflexia à prova calórica. Constataram-se alterações labirínticas que indicaram afecção do sistema vestibular central evidenciando-se a importância dessa avaliação. A existência da possível relação entre os achados com os sintomas vestibulares apresentados pela paciente apontou a relevância do exame labiríntico neste tipo de ataxia uma vez que a presença do nistagmo vertical inferior demonstrou ser frequente neste tipo de patologia.

  16. A Solution-Based Temperature Sensor Using the Organic Compound CuTsPc

    Directory of Open Access Journals (Sweden)

    Shahino Mah Abdullah

    2014-06-01

    Full Text Available An electrochemical cell using an organic compound, copper (II phthalocyanine-tetrasulfonic acid tetrasodium salt (CuTsPc, has been fabricated and investigated as a solution-based temperature sensor. The capacitance and resistance of the ITO/CuTsPc solution/ITO chemical cell has been characterized as a function of temperature in the temperature range of 25–80 °C. A linear response with minimal hysteresis is observed. The fabricated temperature sensor has shown high consistency and sensitive response towards a specific range of temperature values.

  17. Arc Security System Based on Harmonics Detection for the TS ICRH Transmitter

    International Nuclear Information System (INIS)

    Berger-by, G.; Beaumont, B.; Lombard, G.; Millon, L.; Mollard, P.; Volpe, D.

    2006-01-01

    Since 1999 and with the help of I.P.P. (Institut fuer Plasmaphysik) Garching, we have tested in the Tore Supra (T.S.) ICRH transmitter, arcs security systems based on harmonics detection in a frequency band lower than the generator frequency. These systems have been designed for ASDEX in order to discriminate between the arcs and the ELMS mismatches during H-mode plasmas; they have been supplied to T.S. by a loan contract by I.P.P. The first tests done in T.S. were very successful and have permitted in 2000 to build a prototype matching T.S. technical requirements. These systems have some advantages in comparison with traditional securities which are based on use of a level on the V r /V f (Reflected to Forward voltage ratio) calculation . They do not use calculation, calibration with frequency or level. They can use RF signals from directional couplers or probes, so they are fully independent of the measurement systems. The detection bandwidth (4 MHz-35 MHz on TS) is independent of the antennae working frequencies. The detection principle is therefore insensitive to the crosstalk between the antennae and to the antennae coupling variations. The RF arc security box is installed in the generator hall which can be located far from the torus hall and the antennae (about 50 m on T.S.) a feature which is very relevant for the ITER transmitters. In 2001 we have built 3 systems based on our prototype in order to improve the protection of the 3 ICRH generators and antennae. These systems use industrial pass-band filters and a very sensitive linear detection (- 60 dBm) in order to facilitate the adjustment. Optical fibbers are used to transfer, with a very high immunity, the trip information to the generator electronic pilot. To guarantee safe operation, a checking test of the entire security chain is performed with a 10 MHz RF oscillator before each plasma start. The RF principle used on T.S. ICRH transmitter and its electronic interactions with the VME command control of

  18. Safety inspections - the role of TS : risks, their assessment and the role of safety systems

    CERN Document Server

    Béjar-Alonso, Isabel; CERN. Geneva. TS Department

    2008-01-01

    In 2007 the DG decided a new approach for safety at CERN. This had as consequence the creation of a new unit, the safety service provider, in the TS department. The organization and the services that this unit provides to CERN will be described and the achievements since the creation of the unit will be summarized. Some important personnel safety systems, on their side have been the responsibility of the TS Department for many years. Their importance has grown with the arrival of LHC and their complexity and impact on operation has increased. Their role as well as the importance of an appropriate regulatory framework shall be discussed.

  19. Divergência genética entre genótipos de frangos tipo caipira

    Directory of Open Access Journals (Sweden)

    R. C. Veloso

    2015-10-01

    Full Text Available RESUMOObjetivou-se com este trabalho verificar a divergência genética entre sete genótipos de frangos tipo caipira da linhagem Redbro utilizando as características de desempenho por meio de técnicas de análise multivariada. Foram utilizados 840 pintos de um dia, machos, distribuídos em delineamento inteiramente ao acaso, dos seguintes genótipos: Caboclo, Carijó, Colorpak, Gigante Negro, Pesadão Vermelho, Pescoço Pelado e Tricolor. Após a consistência dos dados, foram avaliadas as seguintes variáveis: ganho em peso médio diário, consumo de ração médio diário e conversão alimentar, para os períodos: 1 a 28, 1 a 56, 1 a 70 e 1 a 84 dias de idade; peso corporal ao nascimento, aos 28, 56, 70 e aos 84 dias de idade. O desempenho dos genótipos foi avaliado por meio da análise de variância multivariada e da função discriminante linear de Fisher, usando os testes do maior autovalor de Roy e da união-interseção de Roy para as comparações múltiplas. O estudo da divergência genética foi feito por meio da análise por variáveis canônicas e pelo método de otimização de Tocher. Os genótipos Caboclo e Gigante Negro apresentaram médias canônicas diferentes dos demais genótipos. As duas primeiras variáveis canônicas explicaram 97,41% da variação entre os genótipos. A divergência genética entre os genótipos avaliados permitiu a formação de quatro grupos com os seguintes genótipos: grupo 1 - Colorpak; grupo 2 - Pesadão Vermelho e Pescoço Pelado; grupo 3 - Carijó e Tricolor; e grupo 4 - Caboclo e Gigante Negro.

  20. Function and structure in phage Qbeta RNA replicase. Association of EF-Tu-Ts with the other enzyme subunits

    DEFF Research Database (Denmark)

    Blumenthal, T; Young, R A; Brown, S

    1976-01-01

    of EF-Tu-Ts from the other enzyme subunits: whereas free EF-Tu-Ts binds GDP independently of salt concentration, this binding by Qbeta replicase is sensitive to high ionic strength and remains so in the presence of Qbeta RNA. Furthermore, RNA does not allow the release of EF-Ts from EF-Tu by GTP......Qbeta replicase is a complex of four nonidentical subunits readily dissociable into two subcomplexes: 30 S ribosomal protein S1 and the phage-coded polypeptide (Subunits I + II) and protein synthesis elongation factors EF-Tu and EF-Ts (Subunits III + IV). The affinity of the two subcomplexes...

  1. Efeito do treinamento combinado e aeróbio no controle glicêmico no diabetes tipo 2

    Directory of Open Access Journals (Sweden)

    Antônio Renato Pereira Moro

    Full Text Available INTRODUÇÃO: O diabetes tipo 2 é um grupo heterogêneo de doença metabólica causada por uma disfunção na secreção da insulina e/ou ação desta. OBJETIVOS: Comparar o efeito de duas modalidades de treinamento, o combinado (aeróbio e resistido e o aeróbio, no controle glicêmico no diabetes tipo 2. MATERIAIS E MÉTODOS: A pesquisa caracteriza-se por ser um estudo quase-experimental. Após aprovação do CEP, com registro 09.071.4.08. III, deu-se início ao programa de treinamento combinado e aeróbio. Foram selecionados 24 participantes, de ambos os gêneros, sedentários, com média de idade de 60,41 ± 7,87. Os participantes foram divididos aleatoriamente em dois grupos: treinamento combinado (n = 12 e treinamento aeróbio (n = 12; ambos foram avaliados no início e final do estudo. A concentração sérica de glicose foi determinada pelo sistema Vitros e a hemoglobina glicosilada foi determinada pelo método Cromatografia Líquida de Alta Performance. O treinamento foi realizado três vezes por semana, com duração total de 20 semanas. Os dados são expressos em média e desvio-padrão. Foi aplicado o teste t pareado (p < 0,05 para comparar a média basal e após 20 semanas de treinamento. RESULTADOS: A média da glicose em jejum do treinamento combinado reduziu significativamente, de 167,41 ± 38,13 para 119,83 ± 20,91, sendo que o mesmo ocorreu com o treinamento aeróbio de 189,83 ± 63,57 para 139,91 ± 34,04. Os valores da hemoglobina glicosilada no treinamento combinado e treinamento aeróbio reduziram significativamente, de 8,61 ± 1,17 para 7,25 ± 1,24 e de 9,52 ± 2,46 para 8,37 ± 1,50, respectivamente. CONCLUSÃO: O treinamento combinado foi mais eficaz em relação à hemoglobina glicosilada e o treinamento aeróbio, na glicose plasmática.

  2. Study of the Integration of the CNU-TS-1 Mobile Tunnel Monitoring System.

    Science.gov (United States)

    Du, Liming; Zhong, Ruofei; Sun, Haili; Zhu, Qiang; Zhang, Zhen

    2018-02-01

    A rapid, precise and automated means for the regular inspection and maintenance of a large number of tunnels is needed. Based on the depth study of the tunnel monitoring method, the CNU-TS-1 mobile tunnel monitoring system (TS1) is developed and presented. It can efficiently obtain the cross-sections that are orthogonal to the tunnel in a dynamic way, and the control measurements that depend on design data are eliminated. By using odometers to locate the cross-sections and correcting the data based on longitudinal joints of tunnel segment lining, the cost of the system has been significantly reduced, and the interval between adjacent cross-sections can reach 1-2 cm when pushed to collect data at a normal walking speed. Meanwhile, the relative deformation of tunnel can be analyzed by selecting cross-sections from original data. Through the measurement of the actual tunnel, the applicability of the system for tunnel deformation detection is verified, and the system is shown to be 15 times more efficient than that of the total station. The simulation experiment of the tunnel deformation indicates that the measurement accuracy of TS1 for cross-sections is 1.1 mm. Compared with the traditional method, TS1 improves the efficiency as well as increases the density of the obtained points.

  3. Study of the Integration of the CNU-TS-1 Mobile Tunnel Monitoring System

    Directory of Open Access Journals (Sweden)

    Liming Du

    2018-02-01

    Full Text Available A rapid, precise and automated means for the regular inspection and maintenance of a large number of tunnels is needed. Based on the depth study of the tunnel monitoring method, the CNU-TS-1 mobile tunnel monitoring system (TS1 is developed and presented. It can efficiently obtain the cross-sections that are orthogonal to the tunnel in a dynamic way, and the control measurements that depend on design data are eliminated. By using odometers to locate the cross-sections and correcting the data based on longitudinal joints of tunnel segment lining, the cost of the system has been significantly reduced, and the interval between adjacent cross-sections can reach 1–2 cm when pushed to collect data at a normal walking speed. Meanwhile, the relative deformation of tunnel can be analyzed by selecting cross-sections from original data. Through the measurement of the actual tunnel, the applicability of the system for tunnel deformation detection is verified, and the system is shown to be 15 times more efficient than that of the total station. The simulation experiment of the tunnel deformation indicates that the measurement accuracy of TS1 for cross-sections is 1.1 mm. Compared with the traditional method, TS1 improves the efficiency as well as increases the density of the obtained points.

  4. 75 FR 67705 - Office of Postsecondary Education; Overview Information; Talent Search (TS) Program; Notice...

    Science.gov (United States)

    2010-11-03

    ... DEPARTMENT OF EDUCATION Office of Postsecondary Education; Overview Information; Talent Search (TS... currently being served by a Talent Search project, especially schools that the State has identified as the... reliable third-party sources when providing information on the implementation of their Talent Search...

  5. The E-learning Cabaret: do's and don'ts in E-Learning Design

    NARCIS (Netherlands)

    Westera, Wim

    2009-01-01

    Westera, W. (2006). The E-Learning Cabaret: do's and don'ts in E-Learning Design. Book of Abstracts, 12th International Conference on Technology Supported Learning & Teaching, Online Educa Berlin (pp. 169-171). November, 29-December, 1, 2006, Berlin, Germany: ICWE-GmbH.

  6. Guidelines : the do's, don'ts and don't knows of feedback for clinical education

    NARCIS (Netherlands)

    Lefroy, Janet; Watling, Chris; Teunissen, Pim W; Brand, Paul

    2015-01-01

    INTRODUCTION: The guidelines offered in this paper aim to amalgamate the literature on formative feedback into practical Do's, Don'ts and Don't Knows for individual clinical supervisors and for the institutions that support clinical learning. METHODS: The authors built consensus by an iterative

  7. MEMS startups: disruptive technology and business do's and don'ts

    Science.gov (United States)

    Bryzek, Janusz

    2005-02-01

    This paper characterizes factors that affect the probability of success for new startups. These guidelines are derived primarily from Venture Capital industry experience in funding disruptive technology companies. It follows with an overview of Silicon Valley MEMS and MOEMS startups and provides with a summary of Do"s and Don"ts for entrepreneurs.

  8. 75 FR 38168 - Hazardous Materials: International Regulations for the Safe Transport of Radioactive Material (TS...

    Science.gov (United States)

    2010-07-01

    ... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No. PHMSA-2010-0130 (Notice No.10-2)] Hazardous Materials: International Regulations for the Safe Transport of Radioactive Material (TS-R-1); Draft Revision Available for Comment AGENCY: Pipeline and Hazardous...

  9. Deep-HiTS: Rotation Invariant Convolutional Neural Network for Transient Detection

    Science.gov (United States)

    Cabrera-Vives, Guillermo; Reyes, Ignacio; Förster, Francisco; Estévez, Pablo A.; Maureira, Juan-Carlos

    2017-02-01

    We introduce Deep-HiTS, a rotation-invariant convolutional neural network (CNN) model for classifying images of transient candidates into artifacts or real sources for the High cadence Transient Survey (HiTS). CNNs have the advantage of learning the features automatically from the data while achieving high performance. We compare our CNN model against a feature engineering approach using random forests (RFs). We show that our CNN significantly outperforms the RF model, reducing the error by almost half. Furthermore, for a fixed number of approximately 2000 allowed false transient candidates per night, we are able to reduce the misclassified real transients by approximately one-fifth. To the best of our knowledge, this is the first time CNNs have been used to detect astronomical transient events. Our approach will be very useful when processing images from next generation instruments such as the Large Synoptic Survey Telescope. We have made all our code and data available to the community for the sake of allowing further developments and comparisons at https://github.com/guille-c/Deep-HiTS. Deep-HiTS is licensed under the terms of the GNU General Public License v3.0.

  10. Tsheloveku nuzhen drugoi tshelovek / Jevgeni Tsõmbal ; interv. Nikolai Hrustaljov

    Index Scriptorium Estoniae

    Tsõmbal, Jevgeni

    2008-01-01

    Režissöör Jevgeni Tsõmbal räägib intervjuus oma tööst, Aleksandr Kaidanovskist, kellele ta pühendas dokumentaalfilmi "Snõ Stalkera", Andrei Tarkovskist ja tema filmidest "Stalker" ja "Solaris"

  11. Effects of Tityus serrulatus scorpion venom and its toxin TsTX-V on neurotransmitter uptake in vitro

    International Nuclear Information System (INIS)

    Cecchini, Alessandra L.; Vasconcelos, Flavio; Amara, Susan G.; Giglio, Jose Roberto; Arantes, Eliane Candiani

    2006-01-01

    Scorpion neurotoxins targeting the Na v channel can be classified into two classes: α- and β-neurotoxins and are reported as highly active in mammalian brain. In this work, we evaluate the effects of Tityus serrulatus venom (Ts venom) and its α-neurotoxin TsTX-V on γ-aminobutyric acid (GABA), dopamine (DA) and glutamate (Glu) uptake in isolated rat brain synaptosomes. TsTX-V was isolated from Ts venom by ion exchange chromatography followed by reverse-phase (C18) high-performance liquid chromatography. Neither Ts venom nor TsTX-V was able to affect 3 H-Glu uptake. On the other hand, Ts venom (0.13 μg/mg) significantly inhibited both 3 H-GABA and 3 H-DA uptake (∼ 50%). TsTX-V showed IC 5 values of 9.37 μM and 22.2 μM for the inhibition of 3 H-GABA and 3 H-DA uptake, respectively. These effects were abolished by pre-treatment with tetrodotoxin (TTX, 1 μM), indicating the involvement of voltage-gated Na + channels in this process. In the absence of Ca 2+ , and at low Ts venom concentrations, the reduction of 3 H-GABA uptake was not as marked as in the presence of Ca 2+ . TsTX-V did not reduce 3 H-GABA uptake in COS-7 cells expressing the GABA transporters GAT-1 and GAT-3, suggesting that this toxin indirectly reduces the transport. The reduced 3 H-GABA uptake by synaptosomes might be due to rapid cell depolarization as revealed by confocal microscopy of C6 glioma cells. Thus, TsTX-V causes a reduction of 3 H-GABA and 3 H-DA uptake in a Ca 2+ -dependent manner, not directly affecting GABA transporters, but, in consequence of depolarization, involving voltage-gated Na + channels

  12. TERAPI THOUGTH STOPPING (TS UNTUK ANSIETAS MAHASISWA PRAKTIK KLINIK DI RUMAH SAKIT

    Directory of Open Access Journals (Sweden)

    Eka Malfasari

    2017-10-01

    Full Text Available Anxiety are general problem to nursing student when get clinical pratice in the hospital. Anxiety can cause nursing student have lack performance in the clinical area. Aims of this study was to indentify effectifity of Thought Stopping to reduce student anxiety when get clinical practice in the hospital. The design of this study was quasy experiment with control group. There were 37 control group and 37 intervention groups of student. Anxiety was measured using DASS 21. Thought Stopping impelented three sessions. Result : there are significant different of anxiety between control and intevention group after given TS with p value 0,049 (p value < 0,05. There are 10,703 means different with pre and post test in intervention group. There is significan different with pre and post test in intervention group with p value 0,000 (p value , 0,05. Recomendation : this study can be self therapy to reduce anxiety when get clinical pratice in hospital area. Ansietas adalah masalah umum yang terjadi pada mahasiswa yang sedang menjalani praktik klinik di rumah sakit. Seringkali ansietas menyebabkan performa praktik mahasiswa menjadi menurun. Tujuan penelitian ini adalah untuk mengetahui efektifitas pelaksanaan Thought Stopping (TS untuk mengurangi ansietas mahasiswa keperawatan saat melaksanakan praktik klinik di rumah sakit. Peneltian ini menggunakan design quasy experiment with control group. Terdapat 37 reponden sebagai kelompok kontrol, dan 37 responden sebagai kelompok intervensi. Intervensi TS dilaksanakan selama tiga kali pertemuan. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan tngkat kecemasan pada kelompok kontrol dan intervensi dengan p value 0,049. Perbedaan nilai mean antara kelompok intervensi sebelum dan setelah diberikan TS adalah 10,703. Hal ini menunjukkan terdapat perbedaan yang signifikan kecemasan sebelum dan sesudah diberikan TS dengan p value 0,000 (pvalue,0,05. Penelitian ini diharapkan bisa menjadi panduan

  13. Cloning and Characterization of EF-Tu and EF-Ts from Pseudomonas aeruginosa

    Directory of Open Access Journals (Sweden)

    Stephanie O. Palmer

    2013-01-01

    Full Text Available We have cloned genes encoding elongation factors EF-Tu and EF-Ts from Pseudomonas aeruginosa and expressed and purified the proteins to greater than 95% homogeneity. Sequence analysis indicated that P. aeruginosa EF-Tu and EF-Ts are 84% and 55% identical to E. coli counterparts, respectively. P. aeruginosa EF-Tu was active when assayed in GDP exchange assays. Kinetic parameters for the interaction of EF-Tu with GDP in the absence of EF-Ts were observed to be = 33 μM, = 0.003 s−1, and the specificity constant was  s−1 μM−1. In the presence of EF-Ts, these values were shifted to = 2 μM, = 0.005 s−1, and the specificity constant was  s−1 μM−1. The equilibrium dissociation constants governing the binding of EF-Tu to GDP ( were 30–75 nM and to GTP ( were 125–200 nM. EF-Ts stimulated the exchange of GDP by EF-Tu 10-fold. P. aeruginosa EF-Tu was active in forming a ternary complex with GTP and aminoacylated tRNA and was functional in poly(U-dependent binding of Phe-tRNAPhe at the A-site of P. aeruginosa ribosomes. P. aeruginosa EF-Tu was active in poly(U-programmed polyphenylalanine protein synthesis system composed of all P. aeruginosa components.

  14. Development of an Operational TS Dataset Production System for the Data Assimilation System

    Science.gov (United States)

    Kim, Sung Dae; Park, Hyuk Min; Kim, Young Ho; Park, Kwang Soon

    2017-04-01

    An operational TS (Temperature and Salinity) dataset production system was developed to provide near real-time data to the data assimilation system periodically. It collects the latest 15 days' TS data of the north western pacific area (20°N - 55°N, 110°E - 150°E), applies QC tests to the archived data and supplies them to numerical prediction models of KIOST (Korea Institute of Ocean Science and Technology). The latest real-time TS data are collected from Argo GDAC and GTSPP data server every week. Argo data are downloaded from /latest_data directory of Argo GDAC. Because many duplicated data exist when all profile data are extracted from all Argo netCDF files, DB system is used to avoid duplication. All metadata (float ID, location, observation date and time, etc) of all Argo floats is stored into Database system and a Matlab program was developed to manipulate DB data, to check the duplication and to exclude duplicated data. GTSPP data are downloaded from /realtime directory of GTSPP data service. The latest data except ARGO data are extracted from the original data. Another Matlab program was coded to inspect all collected data using 10 QC tests and produce final dataset which can be used by the assimilation system. Three regional range tests to inspect annual, seasonal and monthly variations are included in the QC procedures. The C program was developed to provide regional ranges to data managers. It can calculate upper limit and lower limit of temperature and salinity at depth from 0 to 1550m. The final TS dataset contains the latest 15 days' TS data in netCDF format. It is updated every week and transmitted to numerical modeler of KIOST for operational use.

  15. Estimation of Uncertainties in the Global Distance Test (GDT_TS for CASP Models.

    Directory of Open Access Journals (Sweden)

    Wenlin Li

    Full Text Available The Critical Assessment of techniques for protein Structure Prediction (or CASP is a community-wide blind test experiment to reveal the best accomplishments of structure modeling. Assessors have been using the Global Distance Test (GDT_TS measure to quantify prediction performance since CASP3 in 1998. However, identifying significant score differences between close models is difficult because of the lack of uncertainty estimations for this measure. Here, we utilized the atomic fluctuations caused by structure flexibility to estimate the uncertainty of GDT_TS scores. Structures determined by nuclear magnetic resonance are deposited as ensembles of alternative conformers that reflect the structural flexibility, whereas standard X-ray refinement produces the static structure averaged over time and space for the dynamic ensembles. To recapitulate the structural heterogeneous ensemble in the crystal lattice, we performed time-averaged refinement for X-ray datasets to generate structural ensembles for our GDT_TS uncertainty analysis. Using those generated ensembles, our study demonstrates that the time-averaged refinements produced structure ensembles with better agreement with the experimental datasets than the averaged X-ray structures with B-factors. The uncertainty of the GDT_TS scores, quantified by their standard deviations (SDs, increases for scores lower than 50 and 70, with maximum SDs of 0.3 and 1.23 for X-ray and NMR structures, respectively. We also applied our procedure to the high accuracy version of GDT-based score and produced similar results with slightly higher SDs. To facilitate score comparisons by the community, we developed a user-friendly web server that produces structure ensembles for NMR and X-ray structures and is accessible at http://prodata.swmed.edu/SEnCS. Our work helps to identify the significance of GDT_TS score differences, as well as to provide structure ensembles for estimating SDs of any scores.

  16. Transport of UF6 in compliance with TS-R-1

    International Nuclear Information System (INIS)

    Dekker, B.G.

    2004-01-01

    The IAEA Regulations TS-R-1 (ST-1, Revised) 1996 Edition include requirements for packages containing uranium hexafluoride (UF6); these are the first and only substance-specific requirements in the IAEA regulations. These requirements have already particularly affected, and will further affect, the transport of non-fissile and fissile excepted UF 6 and the packages used for these transports. Non-fissile and fissile excepted UF6 (ASTM C 787) has been transported worldwide for decades in a safe and reliable manner, using internationally standardised packages. Under the auspices of the World Nuclear Transport Institute (WNTI), an industry working group has been evaluating the existing packages against the requirements in TS-R-1. As new requirements came into effect, there were new challenges for the use of these standard packages, including the free drop test and the thermal requirements. In close cooperation with the WNTI HEXT Industry Working Group, a consortium of UF6 producers/users has worked together on the design and development, testing and certification of technical solutions for modification and optimisation of the existing packages to comply with TS-R-1. This paper reviews the existing standard packages against the requirements in TS-R-1. An update is also given describing the enhancements to the standard packages that have been designed and developed recently. The paper also describes how these solutions have been tested and certified, as well as the status of implementation. Finally, a review is made of the options that are available internationally to transport UF6 in compliance with TS-R-1. (author)

  17. Glaucoma secundario a neurofibromatosis tipo-1

    Directory of Open Access Journals (Sweden)

    Anay Martínez Díaz

    2012-02-01

    Full Text Available Paciente de 59 años de edad, con antecedentes de neurofibromatosis tipo 1 y trauma contuso del ojo derecho desde hace años. Acudió a consulta de oftalmología refiriendo disminución lenta de la visión; al examen físico se constató una agudeza visual de 0.6 en ambos ojos, así como disminución concéntrica del campo visual en la perimetría por confrontación. El examen objetivo mostró en los anexos una pingüécula en ojo derecho y pterigion grado II en ojo izquierdo; en segmento anterior, múltiples nódulos de Lisch en el iris de ambos ojos, y en el ojo derecho, pupila ligeramente midriática, pero reactiva. Se le realizó gonoscopia, oftalmoscopia y perimetría Humphry; en esta última se halló un escotoma arqueado en ojo derecho, y un defecto superior arqueado en el ojo izquierdo. Se concluyó el caso con los diagnósticos de catarata presenil incipiente y glaucoma secundario a neurofibromatosis tipo 1.

  18. "Cremaster' tsükkel" : Matthew Barney avastusretk kunsti ja filmikunsti vahealal / Miriam Dagan ; tõlk. Epp Aareleid

    Index Scriptorium Estoniae

    Dagan, Miriam

    2007-01-01

    Ameerika kunstniku ja režissööri kunstnikufilmidest "Cremaster' tsükkel" (1994-2002). Viie tsükli põhisündmusest. Viienda filmi rekvisiitor oli Meeli Salumäe, Kostabi Maailma assistent New Yorgis

  19. Endocannabinoids blunt the augmentation of synaptic transmission by serotonin 2A receptors in the nucleus tractus solitarii (nTS)

    Science.gov (United States)

    Austgen, James R.; Kline, David D.

    2013-01-01

    Serotonin (5-Hydroxytryptamine, 5-HT) and the 5-HT2 receptor modulate cardiovascular and autonomic function in part through actions in the nTS, the primary termination and integration point for cardiorespiratory afferents in the brainstem. In other brain regions, 5-HT2 receptors (5-HT2R) modify synaptic transmission directly, as well as through 5-HT2AR-induced endocannabinoid release. This study examined the role of 5-HT2AR as well as their interaction with endocannabinoids on neurotransmission in the nucleus tractus solitarii (nTS). Excitatory postsynaptic currents (EPSCs) in monosynaptic nTS neurons were recorded in the horizontal brainstem slice during activation and blockade of 5-HT2ARs. 5-HT2AR activation augmented solitary tract (TS) evoked EPSC amplitude whereas 5-HT2AR blockade depressed TS-EPSC amplitude at low and high TS stimulation rates. The 5-HT2AR-induced increase in neurotransmission was reduced by endocannabinoid receptor block and increased endogenous endocannabinoids in the synaptic cleft during high frequency, but not low, TS stimulation. Endocannabinoids did not tonically modify EPSCs. These data suggest 5-HT acting through the 5-HT2AR is an excitatory neuromodulator in the nTS and its effects are modulated by the endocannabinoid system. PMID:24041777

  20. 77 FR 43817 - Notice of Submission for OMB Review; Office of Postsecondary Education; Talent Search (TS) Annual...

    Science.gov (United States)

    2012-07-26

    ...; Talent Search (TS) Annual Performance Report SUMMARY: The Talent Search program provides Federal... records. Title of Collection: Talent Search (TS) Annual Performance Report. OMB Control Number: Pending... Burden Hours: 7,376. Abstract: Talent Search grantees must submit this report annually. The report...

  1. Simultaneous and multi-criteria optimization of TS requirements and maintenance at NPPs

    International Nuclear Information System (INIS)

    Martorell, S.; Sanchez, A.; Carlos, S.; Serradell, V.

    2002-01-01

    One of the main concerns of the nuclear industry is to improve the availability of safety-related systems at nuclear power plants (NPPs) to achieve high safety levels. The development of efficient testing and maintenance has been traditionally one of the different ways to guarantee high levels of systems availability, which are implemented at NPP through technical specification and maintenance requirements (TS and M). On the other hand, there is a widely recognized interest in using the probabilistic risk analysis (PRA) for risk-informed applications aimed to emphasize both effective risk control and effective resource expenditures at NPPs. TS and M-related parameters in a plant are associated with controlling risk or with satisfying requirements, and are candidate to be evaluated for their resource effectiveness in risk-informed applications. The resource versus risk-control effectiveness principles formally enter in optimization problems where the cost or the burden for the plant staff is to be minimized while the risk or the availability of the safety equipment is constrained to be at a given level, and vice versa. Optimization of TS and M has been found interesting from the very beginning. However, the resolution of such a kind of optimization problem has been limited to focus on only individual TS and M-related parameters (STI, AOT, PM frequency, etc.) and/or adopting an individual optimization criterion (availability, costs, plant risks, etc.). Nevertheless, a number of reasons exist (e.g. interaction, similar scope, etc.) that justify the growing interest in the last years to focus on the simultaneous and multi-criteria optimization of TS and M. In the simultaneous optimization of TS and M-related parameters based on risk (or unavailability) and cost, like in many other engineering optimization problems, one normally faces multi-modal and non-linear objective functions and a variety of both linear and non-linear constraints. Genetic algorithms (GAs) have

  2. Antifungal Activity against Filamentous Fungi of Ts1, a Multifunctional Toxin from Tityus serrulatus Scorpion Venom

    Directory of Open Access Journals (Sweden)

    Welligton M. Santussi

    2017-06-01

    Full Text Available Antimicrobial peptides (AMPs are ubiquitous and multipotent components of the innate immune defense arsenal used by both prokaryotic and eukaryotic organisms. The search for new AMPs has increased in recent years, due to the growing development of microbial resistance to therapeutical drugs. In this work, we evaluate the effects of Tityus serrulatus venom (Tsv, its fractions and its major toxin Ts1, a beta-neurotoxin, on fungi growth. The fractions were obtained by ion-exchange chromatography of Tsv. The growth inhibition of 11 pathogenic and non-pathogenic filamentous fungi (Aspergillus fumigatus, A. nidulans, A. niger, A. terreus, Neurospora crassa, Penicillium corylophilum, P. ochrochloron, P. verrucosum, P. viridicatum, P. waksmanii, and Talaromyces flavus was evaluated by quantitative microplate reader assay. Tsv (100 and 500 μg/well, which correspond to 1 and 5 mg/mL, respectively, of total soluble protein was active in inhibiting growth of A. nidulans, A. terreus, P. corylophilum, and P. verrucosum, especially in the higher concentration used and at the first 30 h. After this period, fungi might have used Tsv components as alternative sources of nutrients, and therefore, increased their growth tax. Only fractions IX, X, XI, XIIA, XIIB (3 and 7.5 μg/well, which correspond to 30 and 75 μg/mL, respectively, of total soluble protein and Ts1 (1.5, 3, and 6 μg/well, which correspond to 2.18, 4.36, and 8.72 μM, respectively showed antifungal activity. Ts1 showed to be a non-morphogenic toxin with dose-dependent activity against A. nidulans, inhibiting 100% of fungal growth from 3 μg/well (4.36 μM. The inhibitory effect of Ts1 against A. nidulans growth was accompanied by fungistatic effects and was not amended by 1 mM CaCl2 or tetrodotoxin (46.98 and 93.96 μM. The structural differences between Ts1 and drosomycin, a potent cysteine-rich antifungal peptide, are discussed here. Our results highlight the antifungal potential of the first

  3. Ejemplares tipo de Asteraceae (= Compositae de A. L. Cabrera

    Directory of Open Access Journals (Sweden)

    Susana E. Freire

    2000-01-01

    Full Text Available Freire, S. E. & Iharlegui, L. 2000. Ejemplares tipo de Asteraceae (= Compositae de A. L.Cabrera. Darwiniana 38(3-4: 307-364.El presente trabajo representa un catálogo de los ejemplares tipo de 426 especies y 82 variedades deAsteraceae descriptas por A. L. Cabrera entre los años 1931 y 1999. Los taxones se presentan en ordenalfabético. Para cada taxón se indica: diagnosis original, tipo nomenclatural, categoría del tipo, herbario,etiqueta original y nombre actualizado

  4. TS Fuzzy Model-Based Controller Design for a Class of Nonlinear Systems Including Nonsmooth Functions

    DEFF Research Database (Denmark)

    Vafamand, Navid; Asemani, Mohammad Hassan; Khayatiyan, Alireza

    2018-01-01

    criterion, new robust controller design conditions in terms of linear matrix inequalities are derived. Three practical case studies, electric power steering system, a helicopter model and servo-mechanical system, are presented to demonstrate the importance of such class of nonlinear systems comprising......This paper proposes a novel robust controller design for a class of nonlinear systems including hard nonlinearity functions. The proposed approach is based on Takagi-Sugeno (TS) fuzzy modeling, nonquadratic Lyapunov function, and nonparallel distributed compensation scheme. In this paper, a novel...... TS modeling of the nonlinear dynamics with signum functions is proposed. This model can exactly represent the original nonlinear system with hard nonlinearity while the discontinuous signum functions are not approximated. Based on the bounded-input-bounded-output stability scheme and L₁ performance...

  5. Hybrid vehicle turbine engine technology support (HVTE-TS) project. 1995--1996 annual report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    This report presents a summary of technical work accomplished on the Hybrid Vehicle Turbine Engine--Technology Support (HVTE-TS) Project during calendar years 1995 and 1996. Work was performed under an initial National Aeronautics and Space Administration (NASA) contract DEN3-336. As of September 1996 the contract administration was transferred to the US Department of Energy (DoE) Chicago Operations Office, and renumbered as DE-AC02-96EE50553. The purpose of the HVTE-TS program is to develop gas turbine engine technology in support of DoE and automotive industry programs exploring the use of gas turbine generator sets in hybrid-electric automotive propulsion systems. The program focus is directed to the development of four key technologies to be applied to advanced turbogenerators for hybrid vehicles: Structural ceramic materials and processes; Low emissions combustion systems; Regenerators and seals systems; and Insulation systems and processes. 60 figs., 9 tabs.

  6. Is 1-hexene epoxidation in TS-1 diffusion limited in different solvents?

    Czech Academy of Sciences Publication Activity Database

    Ramachandran, Ch. E.; Zhao, Q.; Zikánová, Arlette; Kočiřík, Milan; Broadbelt, L. J.; Snurr, R. Q.

    2006-01-01

    Roč. 7, č. 12 (2006), s. 936-940 ISSN 1566-7367 Grant - others:US Department of Energy(US) DE-FG02-03ER15457 Institutional research plan: CEZ:AV0Z40400503 Keywords : PFG NMR * n-hexane diffusivity * 1-hexene epoxidation in TS-1 * silicalite Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.878, year: 2006

  7. Properties of unirradiated fuel element graphites H-451 and TS-1240

    International Nuclear Information System (INIS)

    Johnson, W.R.; Engle, G.B.

    1976-01-01

    Nuclear graphite grades H-451 (Great Lakes Carbon Company) and TS-1240 (Union Carbide Corporation) are described and property data are presented for the unirradiated state. Properties measured included bulk density, ultimate tensile strength, modulus of elasticity, Poisson's ratio, thermal expansivity, and thermal conductivity. The data presented represent the minimum and maximum property values of the prototype full-size production logs and are indicative of property values to be expected in commercial production

  8. T-S criticality of black holes with power Maxwell invariant source

    Science.gov (United States)

    Lin, Ze-Tao; Li, Gu-Qiang; Long, Kun; He, Fang; Mo, Jie-Xiong

    2017-09-01

    In this paper, we show that black holes with PMI source exhibit the T-S criticality and derive the relevant critical physical quantities analytically. The values of critical quantities for the case s≠1 vary from those for the case s=1, showing the effect of PMI field on the critical phenomena of black holes. When qPMI field does not affect the Maxwell equal area law.

  9. Impôts, taxes et équité entre les sexes : codes, comportements et ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    6 déc. 2010 ... On sait que les impôts et la taxation peuvent favoriser l'égalité socioéconomique, mais leurs répercussions sur les disparités entre les sexes demeurent peu ... Selon les constatations du projet, on pourrait rendre les régimes fiscaux plus équitables à l'endroit des femmes sans perturber l'équilibre fiscal.

  10. Le bureau d'études TS/CV/BE pour les besoins du projet LHC

    CERN Document Server

    Martel, C

    2004-01-01

    Le bureau d'études TS/CV/BE propose un appui technique personnalisé aux différentes sections du groupe TS/CV, responsables des projets liés aussi bien à la machine LHC, ses zones expérimentales, que d'autres projets associés. L'équipe, constituée historiquement et exclusivement de personnel d'entreprise extérieure, dispose d'un effectif variable, adapté à des besoins planifiés. Le choix d'utiliser les mêmes logiciels de CAO que la communauté du CERN, a limité la proportion de spécialistes au sein de l'équipe. Une méthodologie particulière a donc été mise en place pour satisfaire les demandes, tout en faisant face à l'étendue et à la complexité des installations de ventilation et de refroidissement. Des compétences externes spécialisées sont également sollicitées, au cas par cas, pour optimiser les coûts de fonctionnement.

  11. Agent Based Fuzzy T-S Multi-Model System and Its Applications

    Directory of Open Access Journals (Sweden)

    Xiaopeng Zhao

    2015-11-01

    Full Text Available Based on the basic concepts of agent and fuzzy T-S model, an agent based fuzzy T-S multi-model (ABFT-SMM system is proposed in this paper. Different from the traditional method, the parameters and the membership value of the agent can be adjusted along with the process. In this system, each agent can be described as a dynamic equation, which can be seen as the local part of the multi-model, and it can execute the task alone or collaborate with other agents to accomplish a fixed goal. It is proved in this paper that the agent based fuzzy T-S multi-model system can approximate any linear or nonlinear system at arbitrary accuracy. The applications to the benchmark problem of chaotic time series prediction, water heater system and waste heat utilizing process illustrate the viability and the efficiency of the mentioned approach. At the same time, the method can be easily used to a number of engineering fields, including identification, nonlinear control, fault diagnostics and performance analysis.

  12. ERCC1 and TS Expression as Prognostic and Predictive Biomarkers in Metastatic Colon Cancer.

    Directory of Open Access Journals (Sweden)

    Michel B Choueiri

    Full Text Available In patients with metastatic colon cancer, response to first line chemotherapy is a strong predictor of overall survival (OS. Currently, oncologists lack diagnostic tests to determine which chemotherapy regimen offers the greatest chance for response in an individual patient. Here we present the results of gene expression analysis for two genes, ERCC1 and TS, measured with the commercially available ResponseDX: Colon assay (Response Genetics, Los Angeles, CA in 41 patients with de novo metastatic colon cancer diagnosed between July 2008 and August 2013 at the University of California, San Diego. In addition ERCC1 and TS expression levels as determined by RNAseq and survival data for patients in TCGA were downloaded from the TCGA data portal. We found that patients with low expression of ERCC1 (n = 33 had significantly longer median OS (36.0 vs. 10.1 mo, HR 0.29, 95% CI .095 to .84, log-rank p = 9.0x10-6 and median time to treatment to failure (TTF following first line chemotherapy (14.1 vs. 2.4 mo, HR 0.17, 95% CI 0.048 to 0.58, log-rank p = 5.3x10-4 relative to those with high expression (n = 4. After accounting for the covariates age, sex, tumor grade and ECOG performance status in a Cox proportional hazard model the association of low ERCC1 with longer OS (HR 0.18, 95% CI 0.14 to 0.26, p = 0.0448 and TTF (HR 0.16, 95% CI 0.14 to 0.21, p = 0.0053 remained significant. Patients with low TS expression (n = 29 had significantly longer median OS (36.0 vs. 14.8 mo, HR 0.25, 95% CI 0.074 to 0.82, log-rank p = 0.022 relative to those with high expression (n = 12. The combined low expression of ERCC1/TS was predictive of response in patients treated with FOLFOX (40% vs. 91%, RR 2.3, Fisher's exact test p = 0.03, n = 27, but not with FOLFIRI (71% vs. 71%, RR 1.0, Fisher's exact test p = 1, n = 14. Overall, these findings suggest that measurement of ERCC1 and TS expression has potential clinical utility in managing patients with metastatic colorectal

  13. Comprometimento medular por linfoma tipo Burkitt: relato de um caso

    Directory of Open Access Journals (Sweden)

    Murillo Côrtes Drummond

    1985-06-01

    Full Text Available Registro de caso de linfoma tipo Burkitt com comprometimento intrarraqueano em criança de três anos de idade. Considerações sobre esse tipo de tumor são feitas em função do caso observado e de dados da literatura.

  14. In vitro pre-selection criteria for probiotic Lactobacillus acidophilus TS1 isolated from fermented milk product, Dahi

    Directory of Open Access Journals (Sweden)

    Maqsood, S.

    2013-12-01

    Full Text Available Aims: The aim of this research was to evaluate some probiotic traits of Lactobacillus acidophilus TS1 strain previously isolated from dahi. Methodology and results: For this purpose, tested strain was evaluated for their resistance to low pH, tolerance to bile and in vitro antibiotics susceptibility. It was observed that the strain TS1 remained viable at pH 3.0 to 6 and bile concentration of 0.1 to 0.3%. Conclusion, significance and impact of study: L. acidophilus TS1 was found resistant to nalidixic acid, ciprofloxacine, gentamycin and vancomycin. The results highlighted the probiotic potential of L. acidophilus TS1 which deserves further investigation in vitro studies to elucidate its health benefits.

  15. Function and structure in phage Qbeta RNA replicase. Association of EF-Tu-Ts with the other enzyme subunits

    DEFF Research Database (Denmark)

    Blumenthal, T; Young, R A; Brown, S

    1976-01-01

    of EF-Tu-Ts from the other enzyme subunits: whereas free EF-Tu-Ts binds GDP independently of salt concentration, this binding by Qbeta replicase is sensitive to high ionic strength and remains so in the presence of Qbeta RNA. Furthermore, RNA does not allow the release of EF-Ts from EF-Tu by GTP...... for one another increases with increasing ionic strength. The enzyme is capable of initiation of RNA synthesis with synthetic templates only when in the low ionic strength conformation. Elongation of initiated polynucleotide chains is not affectedby ionic strength. Addition of Qbeta RNA to the enzyme also...... alters its quaternary structure: the EF-Tu-Ts cannot be covalently attached to the other enzyme subunits with bifunctional cross-linking reagents in the presence of RNA. This conformational change is not influenced by ionic strength. The addition of Qbeta RNA to the enzyme, does not result in the release...

  16. 2000 Jahre Varusschlacht: Bücher aus dem Bestand der Universitäts- und Landesbibliothek Münster

    OpenAIRE

    Mühl, H. (Hans)

    2014-01-01

    Verzeichnis selbständiger Schriften zur Varusschlacht, ihrer Erforschung und Rezeption aus dem Bestand der Universitäts- und Landesbibliothek Münster (mit Signaturangaben) zum Jubiläum der Varusschlacht 2009.

  17. Towards an estimation of water masses formation areas from SMOS-based TS diagrams

    Science.gov (United States)

    Klockmann, Marlene; Sabia, Roberto; Fernandez-Prieto, Diego; Donlon, Craig; Font, Jordi

    2014-05-01

    Temperature-Salinity (TS) diagrams emphasize the mutual variability of ocean temperature and salinity values, relating them to the corresponding density. Canonically used in oceanography, they provide a means to characterize and trace ocean water masses. In [1], a first attempt to estimate surface-layer TS diagrams based on satellite measurements has been performed, profiting from the recent availability of spaceborne salinity data. In fact, the Soil Moisture and Ocean Salinity (SMOS, [2]) and the Aquarius/SAC-D [3] satellite missions allow to study the dynamical patterns of Sea Surface Salinity (SSS) for the first time on a global scale. In [4], given SMOS and Aquarius salinity estimates, and by also using Sea Surface Temperature (SST) from the Operational Sea Surface Temperature and Sea Ice Analysis (OSTIA, [5]) effort, experimental satellite-based TS diagrams have been routinely derived for the year 2011. They have been compared with those computed from ARGO-buoys interpolated fields, referring to a customised partition of the global ocean into seven regions, according to the water masses classification of [6]. In [7], moreover, besides using TS diagrams as a diagnostic tool to evaluate the temporal variation of SST and SSS (and their corresponding density) as estimated by satellite measurements, the emphasis was on the interpretation of the geographical deviations with respect to the ARGO baseline (aiming at distinguishing between the SSS retrieval errors and the additional information contained in the satellite data with respect to ARGO). In order to relate these mismatches to identifiable oceanographic structures and processes, additional satellite datasets of ocean currents, evaporation/precipitation fluxes, and wind speed have been super-imposed. Currently, the main focus of the study deals with the exploitation of these TS diagrams as a prognostic tool to derive water masses formation areas. Firstly, following the approach described in [8], the surface

  18. Lesao óssea em leucemias agudas linfoblásticas tipo T e TIPO nao T / nao B

    OpenAIRE

    Martins, Fernando Lopes

    2013-01-01

    Resumo: O AUTOR APRESENTA OS RESULTADOS DO ESTUDO RADIOLÓGICO DE ESQUELETO DE 61 PACIENTES PORTADORES DE LEUCEMIA AGUDA LINFOBLÁSTICA, CORRELACIONANDO A PRESENÇA OU NÃO DE Lesões ÓSSEAS COM A CLASSIFICAÇÃO IMUNOLÓGICA DE LAL TIPO T E TIPO não T / não B

  19. Tipos especiales de niños

    Directory of Open Access Journals (Sweden)

    Mercedes Rodrigo Bellido

    1946-09-01

    Full Text Available En las tres últimas lecciones han sido expuestas algunas consideraciones referentes a niños y adolescentes desde el nacimiento hasta el dintel de la juventud. En todas ellas hemos procurado poner de relieve la necesidad de individualizar el conocimiento de cada niño para obtener mejores resultados en su adaptación a su futura vida de adultos, En todas ellas  nos hemos referido al llamado niño normal. Nos corresponde en la lección de hoy ocuparnos can la superficialidad característica de estas charlas tipo-muestrario, de otras categorías de niños muy dignos de interés.. quienes unas por exceso, otros por defecto, otros por dificultades de adaptación por diferentes causas, se desvían de la línea media de la normalidad. Consideramos que no está fuera del lugar, aquí, el tema de los niños excepcionales y por el contrario que es necesario intensificar el estudio de los trastornos de la vida mental y emocional de los niños en la preparación de los estudiantes de Medicina. Y no es nuestra solo esta opinión; no hace mucho tiempo en la Medical School de Ia Universidad de Minnessota hemos sabido que se ha hecho un intento de considerar y evaluar factores emocionales ambientales sobre las mismas bases que los descubrimientos fisiológicos.

  20. Guidelines: the do's, don'ts and don't knows of feedback for clinical education.

    Science.gov (United States)

    Lefroy, Janet; Watling, Chris; Teunissen, Pim W; Brand, Paul

    2015-12-01

    The guidelines offered in this paper aim to amalgamate the literature on formative feedback into practical Do's, Don'ts and Don't Knows for individual clinical supervisors and for the institutions that support clinical learning. The authors built consensus by an iterative process. Do's and Don'ts were proposed based on authors' individual teaching experience and awareness of the literature, and the amalgamated set of guidelines were then refined by all authors and the evidence was summarized for each guideline. Don't Knows were identified as being important questions to this international group of educators which if answered would change practice. The criteria for inclusion of evidence for these guidelines were not those of a systematic review, so indicators of strength of these recommendations were developed which combine the evidence with the authors' consensus. A set of 32 Do and Don't guidelines with the important Don't Knows was compiled along with a summary of the evidence for each. These are divided into guidelines for the individual clinical supervisor giving feedback to their trainee (recommendations about both the process and the content of feedback) and guidelines for the learning culture (what elements of learning culture support the exchange of meaningful feedback, and what elements constrain it?) Feedback is not easy to get right, but it is essential to learning in medicine, and there is a wealth of evidence supporting the Do's and warning against the Don'ts. Further research into the critical Don't Knows of feedback is required. A new definition is offered: Helpful feedback is a supportive conversation that clarifies the trainee's awareness of their developing competencies, enhances their self-efficacy for making progress, challenges them to set objectives for improvement, and facilitates their development of strategies to enable that improvement to occur.

  1. Alignment of CT-PPS detectors in 2016, before TS2

    CERN Document Server

    Kaspar, J

    2017-01-01

    This note presents the first alignment of the CMS-TOTEM Precision Proton Spectrometer (CT-PPS) using the data from before Technical Stop 2 (TS2), 2016. This new procedure involves two stages. In the first one, data from a special calibration fill are used. In this fill, both horizontal and vertical Roman Pots (RPs) were inserted very close to the beam. In the second stage, hit distributions from physics fills (with only horizontal RPs inserted) are matched to the previously aligned reference from the calibration fill. The alignment and optics calibration is verified by reconstructing consistent $\\xi$ spectra from different RPs and LHC fills.

  2. Chemical Characterization of N-Linked Oligosaccharide As the Antigen Epitope Recognized by an Anti-Sperm Auto-Monoclonal Antibody, Ts4.

    Directory of Open Access Journals (Sweden)

    Hiroshi Yoshitake

    Full Text Available Ts4, an anti-sperm auto-monoclonal antibody, possesses immunoreactivity to the acrosomal region of mouse epididymal spermatozoa. In addition, the mAb shows specific immunoreactivity to reproduction-related regions such as testicular germ cells and early embryo. Our qualitative study previously showed that the antigen epitope for Ts4 contained a N-linked common oligosaccharide (OS chain on testicular glycoproteins as determined by Western blotting for testicular glycoproteins after treatment with several glycohydrolases. Since the distribution of the Ts4-epitope is unique, the OS chain in Ts4-epitope may have role(s in the reproductive process. The aim of this study was to clarify the molecular structure of the Ts4-epitope, particularly its OS moiety. Using Ts4 immunoprecipitation combined with liquid chromatography and multiple-stage mass spectrometry, the candidate carbohydrate structure in the Ts4-epitope is proposed to be N-linked fucosylated agalacto-biantennary with bisecting N-acetylglucosamine (GlcNAc or with N-acetylgalactosamine-GlcNAc motif. Further binding analyses using various lectins against the mouse testicular Ts4-immunoprecipitants revealed that Phaseolus vulgaris erythroagglutinin and Pisum sativum agglutinin showed positive staining of the bands corresponding to Ts4 reactive proteins. Moreover, the immunoreactivity of Ts4 against the testicular extract was completely abrogated after digestion with β-N-acetylglucosaminidase. These results show that the Ts4-epitope contains agalacto-biantennary N-glycan with bisecting GlcNAc carrying fucose residues.

  3. Fenótipo Rett em paciente com cariótipo XXY: relato de caso

    Directory of Open Access Journals (Sweden)

    SCHWARTZMAN JOSÉ SALOMÃO

    1998-01-01

    Full Text Available Relatamos o caso de um menino com cariótipo XXY que apresenta desordem neurológica progressiva com início por volta dos 11 meses de idade, com estagnação do desenvolvimento seguida de regressão. A criança apresenta, ainda, movimentos estereotipados de mãos, apraxia manual e microcefalia. Investigações não constataram presença de qualquer condição neurológica ou sistêmica definida que pudesse ser apontada como possível etiologia para o quadro descrito. Trata-se de menino com alterações fenotípicas muito similares àquelas consideradas típicas para a síndrome de Rett que, associadas com a alteração cromossômica constatada (cariótipo XXY, constituem quadro de evidente interesse científico.

  4. Nuevo tipo de apoyos y articulaciones

    Directory of Open Access Journals (Sweden)

    Andrä, Fritz Leonhardt

    1963-11-01

    of theoretical and technical difficulties inherent in these bearings: they also express acknowledgement to German individuals and institutions, for their contribution to this investigation.Las tendencias actuales son funciones que dependen directamente de la presencia creciente y mejorada de los materiales de construcción que se ofrecen al comercio. En el campo de los materiales cabe una marcada subdivisión en naturales y preparados o sintéticos; estos últimos constituyen la preocupación de los autores para su aprovechamiento y adecuada aplicación. De entre ellos, las resinas sintéticas o caucho artificial, dentro de las distintas especies de la extensa familia han gozado de un lugar preferente en este estudio de nuevos tipos de apoyos que presentan los notables ingenieros alemanes Wolfhart Andrä y Fritz Leonhardt. En los ensayos de laboratorio y a escala natural, las variedades comerciales de estas resinas, conocidas con los nombres de «neopreno» y «Teflon», han sido elegidas por presentar, por lo menos actualmente, características marcadamente apropiadas a la finalidad perseguida en este estudio, del que se confía ulterior desarrollo y mejor acogida, por las importantes aplicaciones que de él se derivan en el campo de la ingeniería y construcción. Los autores estudian con detenimiento y sobrado rigor para las aplicaciones prácticas las deformaciones que de estos materiales se espera al someterlos a fuerzas de gran concentración. En los apoyos juega particular interés la distribución de la carga siempre concentrada en superficies relativamente pequeñas, lo que exige elevadas cargas unitarias y, con ello, la utilización de materiales extremadamente nobles para resistirlas con la resistencia que las deformaciones instantáneas requieren para recobrar rápidamente la posición de estabilidad perdida momentáneamente. La fatiga en el ciclo de deformaciones relaja los materiales, y ha de tenerse presente al considerar las características que los

  5. Impôts en France : réunion publique le mercredi 19 mars 2014

    CERN Document Server

    CERN. Geneva

    2014-01-01

    Impôts en France : réunion publique le mercredi 19 mars 2014 Une réunion publique aura lieu le mercredi 19 mars de 13h à 15h dans l’amphithéâtre principal (500/1-001). Au cours de cette réunion, MM. Jean-Louis Brandolin et Gérard Polizzi, respectivement responsable et responsable-adjoint du Service des impôts des particuliers et des entreprises de Bellegarde, Centre des finances publiques, apporteront leur expertise au sujet de l’imposition des membres du personnel du CERN domiciliés en France. Seront à l’ordre du jour les questions de principe que se posent apparemment de nombreux membres du personnel : par exemple, la définition du domicile fiscal, le contenu de la déclaration de revenus (mention des revenus CERN et déclaration des autres revenus de sources française ou étrangère), la déclaration des comptes bancaires à l’étranger, l’assujettissement (dans certaines conditions) à la CSG-CRDS. Cette réunion publique portera UNIQUEMENT sur des questions de principe ...

  6. Second Generation HTs Wire Based on RABiTS Substrates and MOD YBCO

    Energy Technology Data Exchange (ETDEWEB)

    Schoop, U. [American Superconductor Corporation, Westborough, MA; Rupich, Marty [American Superconductor Corporation, Westborough, MA; Thieme, C. L. H. [American Superconductor Corporation, Westborough, MA; Verebelyi, D. T. [American Superconductor Corporation, Westborough, MA; Zhang, W. [American Superconductor Corporation, Westborough, MA; Li, Xiaoping [American Superconductor Corporation, Westborough, MA; Kodenkandath, Thomas [American Superconductor Corporation, Westborough, MA; Nguyen, N. [American Superconductor Corporation, Westborough, MA; Siegal, E. E. [American Superconductor Corporation, Westborough, MA; Civale, L. [Los Alamos National Laboratory (LANL); Holesinger, T. G. [Los Alamos National Laboratory (LANL); Maiorov, B. [Los Alamos National Laboratory (LANL); Goyal, Amit [ORNL; Paranthaman, Mariappan Parans [ORNL

    2005-01-01

    The performance of Second Generation (2G) high temperature superconducting wire manufactured by continuous reel-to-reel processes is nearing the 300 A/cm-width (77 K, self field) performance threshold for commercial power cable applications. The 2G manufacturing approach under development at American Superconductor is based on the combination of the RABiTS substrate-buffer technology with metal organic deposition (MOD) of the YBCO layer. The capability of this process has been demonstrated in multiple 10 meter lengths with critical currents exceeding 250 A/cm-width with high uniformity and reproducibility. Critical currents of 380 A/cm-width have been achieved in short length samples prepared by the same basic process. The incorporation of nanoparticles ('nanodots') into the YBCO layer using the MOD process has resulted in a 2-fold improvement in the critical current at 65 K in a 3 T field. The research and development focus at ASMC is now directed toward the economical scale-up of the RABiTS/MOD process, optimization of the conductor properties for targeted applications and the use of 2G wire in initial demonstration applications.

  7. Progress on MOD/RABiTS{sup TM} 2G HTS wire

    Energy Technology Data Exchange (ETDEWEB)

    Rupich, M.W.; Zhang, W.; Li, X.; Kodenkandath, T.; Verebelyi, D.T.; Schoop, U.; Thieme, C.; Teplitsky, M.; Lynch, J.; Nguyen, N.; Siegal, E.; Scudiere, J.; Maroni, V.; Venkataraman, K.; Miller, D.; Holesinger, T.G

    2004-10-01

    The development of the second generation (2G) high temperature superconducting wire has advanced beyond initial laboratory demonstrations and is now focused on developing and testing high critical current conductor designs required for commercial applications. The approach pursued at American Superconductor for 2G wire manufacturing is based on the combination of the RABiTS{sup TM} substrate-buffer technology with metal organic deposition (MOD) of the YBCO layer. This MOD/RABiTS{sup TM} approach has been demonstrated in 10 m lengths with critical currents of up to 184 A/cm-width ({approx}2.3 MA/cm{sup 2}) and in short length with critical currents of up to 270 A/cm-width ({approx}3.4 MA/cm{sup 2}). In addition to a high critical current, the superconducting wire must also meet stringent mechanical and electrical stability requirements that vary by application. Commercially viable architectures designed to meet these specifications have been fabricated and tested. Wires manufactured by this process have been successfully tested in prototype cable and coil applications.

  8. Ultrasonic vocalizations during male-female interaction in the mouse model of Down syndrome Ts65Dn.

    Science.gov (United States)

    Zampieri, Bruna L; Fernandez, Fabian; Pearson, Jennifer N; Stasko, Melissa R; Costa, Alberto C S

    2014-04-10

    Down syndrome (DS) is the leading cause of genetically defined intellectual disability. Although speech and language impairments are salient features of this disorder, the nature of these phenotypes and the degree to which they are exacerbated by concomitant oromotor dysfunction and/or hearing deficit are poorly understood. Mouse models like Ts65Dn, the most extensively used DS animal model, have been critical to understanding the genetic and developmental mechanisms that contribute to intellectual disability. In the present study, we characterized the properties of the ultrasonic vocalizations (USVs) emitted by Ts65Dn males during courtship episodes with female partners. USVs emitted by mice in this setting have been proposed to have some basic correlation to human speech. Data were collected and analyzed from 22 Ts65Dn mice and 22 of their euploid littermates. We found that both the minimum and maximum peak frequencies of Ts65Dn calls were lower than those produced by euploid mice, whereas the mean individual duration of "down" and "complex" syllable types was significantly longer. Peak, minimal and maximal, and the fundamental frequencies of short syllables generated by Ts65Dn mice were lower compared to those by euploid mice. Finally, Ts65Dn males made fewer multiple jumps calls during courtship and the mean total duration of their "arc", "u", and "complex" syllables was longer. We discuss the human correlates to these findings, their translational potential, and the limitations of this approach. To our knowledge, this is the first characterization of differences between adult Ts65Dn and euploid control mice with respect to USVs. Copyright © 2014 Elsevier Inc. All rights reserved.

  9. SÍNDROME DE MORQUIO (MUCOPOLISACARIDOSIS TIPO IV) Y EMBARAZO

    OpenAIRE

    Salinas P.,Hugo; Preisler R.,Jessica; Astudillo D.,Julio; Cerda S.M.,Sergio; Castillo T.,Silvia; Fernández S.,Flor; Ide V.,Rodolfo

    2005-01-01

    Se presenta el caso de una paciente embarazada, portadora de Síndrome de Morquio (Mucopolisacaridosis tipo IV), que evoluciona con polihidroamnios y disnea. Se comenta el manejo y resolución del caso

  10. OTROS TIPOS ESPECÍFICOS DE DIABETES MELLITUS

    Directory of Open Access Journals (Sweden)

    DRA. M. Gabriela Sanzana G.

    2016-03-01

    En las “Diabetes Atípicas” (no incluidas en la clasificación ADA, se mencionan la DM tipo 2 en niños y adolescentes, favorecida por el aumento de la obesidad y del sedentarismo; la diabetes propensa a la cetosis, que debutan en cetoacidosis, con etiopatogenia y evolución de DM2; los Latent Autoinmune Diabetes of Adults (LADA, DM tipo 1 de lenta aparición y la diabetes postrasplante.

  11. Heterologous expression of rTsHyal-1: the first recombinant hyaluronidase of scorpion venom produced in Pichia pastoris system.

    Science.gov (United States)

    Amorim, Fernanda Gobbi; Boldrini-França, Johara; de Castro Figueiredo Bordon, Karla; Cardoso, Iara Aimê; De Pauw, Edwin; Quinton, Loïc; Kashima, Simone; Arantes, Eliane Candiani

    2018-04-01

    In general, hyaluronidases have a broad potential application on medicine and esthetics fields. Hyaluronidases from animal venoms cleave hyaluronan present in the extracellular matrix, acting as spreading factors of toxins into the tissues of the victim. However, the in-depth characterization of hyaluronidase from animal venoms has been neglected due to its instability and low concentration in the venom, which hamper its isolation. Thus, heterologous expression of hyaluronidase acts as a biotechnological tool in the obtainment of enough amounts of the enzyme for structural and functional studies. Therefore, this study produced a recombinant hyaluronidase from Tityus serrulatus scorpion venom, designated as rTsHyal-1, in the Pichia pastoris system. Thus, a gene for TsHyal-1 (gb|KF623285.1) was synthesized and cloned into the pPICZαA vector (GenScript Corporation) for heterologous expression in P. pastoris. rTsHyal-1 was expressed in laboratorial scale in a buffered minimal medium containing methanol (BMM) for 96 h with daily addition of methanol. Expression of rTsHyal-1 resulted in a total protein yield of 0.266 mg/mL. rTsHyal-1 partially purified through cation exchange chromatography presented a specific activity of 1097 TRU/mg, against 838 TRU/mg for the final expressed material, representing a 1.31-fold purification. rTsHyal-1 has molecular mass of 49.5 kDa, and treatment with PNGase F and analysis by mass spectrometry (MALDI-TOF) indicated a potential N-glycosylation of 4.5 kDa. Additionally, de novo sequencing of rTsHyal-1, performed in MALDI-TOF and Q Exactive Orbitrap MS, resulted in 46.8% of protein sequence coverage. rTsHyal-1 presents the highest substrate specificity to hyaluronan followed by chondroitin-6-sulfate, chondroitin-4-sulfate, and dermatan sulfate and showed an optimum activity at pH 6.0 and 40 °C. These results validate the biotechnological process for the heterologous expression of rTsHyal-1. This is the first recombinant

  12. The Prediction of the Gas Utilization Ratio based on TS Fuzzy Neural Network and Particle Swarm Optimization

    Directory of Open Access Journals (Sweden)

    Sen Zhang

    2018-02-01

    Full Text Available Gas utilization ratio (GUR is an important indicator that is used to evaluate the energy consumption of blast furnaces (BFs. Currently, the existing methods cannot predict the GUR accurately. In this paper, we present a novel data-driven model for predicting the GUR. The proposed approach utilized both the TS fuzzy neural network (TS-FNN and the particle swarm algorithm (PSO to predict the GUR. The particle swarm algorithm (PSO is applied to optimize the parameters of the TS-FNN in order to decrease the error caused by the inaccurate initial parameter. This paper also applied the box graph (Box-plot method to eliminate the abnormal value of the raw data during the data preprocessing. This method can deal with the data which does not obey the normal distribution which is caused by the complex industrial environments. The prediction results demonstrate that the optimization model based on PSO and the TS-FNN approach achieves higher prediction accuracy compared with the TS-FNN model and SVM model and the proposed approach can accurately predict the GUR of the blast furnace, providing an effective way for the on-line blast furnace distribution control.

  13. La connaissance des coûts complets des activités et autres outils de management

    CERN Document Server

    Leconte, A

    1998-01-01

    Ce sont les activités qui consomment les ressources et non les produits. L'analyse des activités doit passer par "value analysis" et par "re-engineering". Les coûts complets comprennent: frais fixes, variables, et coûts cachés. Les coûts sont à comparer par "benchmarking". On peut pratiquer le "target costing. La principale source des coûts est générée par les ressources humaines, même si les différences entre les savoir-faire diminuent, c'est sur le vouloir que tout se joue. Vouloir en particulier la satisfaction du client conduit au T.Q.M. Le management des projets est une affaire de communication et d'intégration de différentes logiques. Les prix de cessions internes sont issus du coût complet, partiel, ou du prix du marché. Enfin, connaissance et comparaison des coûts des activités sont déterminantes face à l'alternative Faire ou Faire-faire.

  14. The Prediction of the Gas Utilization Ratio based on TS Fuzzy Neural Network and Particle Swarm Optimization.

    Science.gov (United States)

    Zhang, Sen; Jiang, Haihe; Yin, Yixin; Xiao, Wendong; Zhao, Baoyong

    2018-02-20

    Gas utilization ratio (GUR) is an important indicator that is used to evaluate the energy consumption of blast furnaces (BFs). Currently, the existing methods cannot predict the GUR accurately. In this paper, we present a novel data-driven model for predicting the GUR. The proposed approach utilized both the TS fuzzy neural network (TS-FNN) and the particle swarm algorithm (PSO) to predict the GUR. The particle swarm algorithm (PSO) is applied to optimize the parameters of the TS-FNN in order to decrease the error caused by the inaccurate initial parameter. This paper also applied the box graph (Box-plot) method to eliminate the abnormal value of the raw data during the data preprocessing. This method can deal with the data which does not obey the normal distribution which is caused by the complex industrial environments. The prediction results demonstrate that the optimization model based on PSO and the TS-FNN approach achieves higher prediction accuracy compared with the TS-FNN model and SVM model and the proposed approach can accurately predict the GUR of the blast furnace, providing an effective way for the on-line blast furnace distribution control.

  15. Comparison of TS and ANN Models with the Results of Emission Scenarios in Rainfall Prediction

    Directory of Open Access Journals (Sweden)

    S. Babaei Hessar

    2016-02-01

    Full Text Available Introduction: Precipitation is one of the most important and sensitive parameters of the tropical climate that influence the catchments hydrological regime. The prediction of rainfall is vital for strategic planning and water resources management. Despite its importance, statistical rainfall forecasting, especially for long-term, has been proven to be a great challenge due to the dynamic nature of climate phenomena and random fluctuations involved in the process. Various methods, such as time series and artificial neural network models, have been proposed to predict the level of rainfall. But there is not enough attention to global warming and climate change issues. The main aim of this study is to investigate the conformity of artificial neural network and time series models with climate scenarios. Materials and Methods: For this study, 50 years of daily rainfall data (1961 to 2010 of the synoptic station of Urmia, Tabriz and Khoy was investigated. Data was obtained from Meteorological Organization of Iran. In the present study, the results of two Artificial Neural Network (ANN and Time Seri (TS methods were compared with the result of the Emission Scenarios (A2 & B1. HadCM3 model in LARS-WG software was used to generate rainfall for the next 18 years (2011-2029. The results of models were compared with climate scenarios over the next 18 years in the three synoptic stations located in the basin of the Lake Urmia. At the first stage, the best model of time series method was selected. The precipitation was estimated for the next 18 years using these models. For the same period, precipitation was forecast using artificial neural networks. Finally, the results of two models were compared with data generated under two scenarios (B1 and A2 in LARS-WG. Results and Discussion: Different order of AR, MA and ARMA was examined to select the best model of TS The results show that AR(1 was suitable for Tabriz and Khoy stations .In the Urmia station MA(1 was

  16. Simulation of Irradiated BWR fuel rod (TS) test in NSRR using FRAP-T6 and NSR-77

    International Nuclear Information System (INIS)

    Nakamura, Takehiko; Murofushi, Akira; Hosoyamada, Ryuji.

    1994-03-01

    Series of pulse irradiation tests have been performed in the Nuclear Safety Research Reactor (NSRR) to investigate irradiated fuel rod performance under the Reactivity Initiated Accident (RIA) conditions. Five tests, called Tests TS-1 through TS-5, were conducted in a period from 1989 to 1993 with irradiated 7x7 type BWR fuel rods provided from a commercial power plant. Simulation calculations of the TS tests were carried out with the FRAP-T6 code, which is widely used in the world to estimate fuel performance under various accident conditions, and with the NSR77 code, which describes fresh fuel rod performance well in the NSRR tests. Results of the calculation are compiled in this report and applicability of the codes to the irradiated BWR fuel rod tests is discussed. (author)

  17. Heterologous Prime-Boost Vaccination Enhances TsPmy’s Protective Immunity against Trichinella spiralis Infection in a Murine Model

    Directory of Open Access Journals (Sweden)

    Lei Wang

    2017-07-01

    Full Text Available TsPmy is a paramyosin expressed by parasitic Trichinella spiralis and confers a protective immunity when its recombinant protein or DNA was used as an immunogen. To improve its immunogenicity and vaccine efficacy, we conducted a heterologous prime-boost strategy by orally delivering one dose of TsPmy DNA carried by attenuated Salmonella typhimurium (SL7207, followed by two doses of recombinant TsPmy intramuscularly. This strategy effectively induced intestinal mucosal sIgA response and an enhanced and balanced Th1/Th2 immune responses that improve protection against T. spiralis larval challenge, with 55.4% muscle larvae reduction and 41.8% adult worm reduction compared to PBS control. The muscle larvae reduction induced by heterologous prime-boost regimen was significant higher than that induced by the homologous DNA or protein prime-boost regimens, which could act as a practical prophylactic approach to prevent T. spiralis infection.

  18. A Novel Adjustment Method for Shearer Traction Speed through Integration of T-S Cloud Inference Network and Improved PSO

    Directory of Open Access Journals (Sweden)

    Lei Si

    2014-01-01

    Full Text Available In order to efficiently and accurately adjust the shearer traction speed, a novel approach based on Takagi-Sugeno (T-S cloud inference network (CIN and improved particle swarm optimization (IPSO is proposed. The T-S CIN is built through the combination of cloud model and T-S fuzzy neural network. Moreover, the IPSO algorithm employs parameter automation adjustment strategy and velocity resetting to significantly improve the performance of basic PSO algorithm in global search and fine-tuning of the solutions, and the flowchart of proposed approach is designed. Furthermore, some simulation examples are carried out and comparison results indicate that the proposed method is feasible, efficient, and is outperforming others. Finally, an industrial application example of coal mining face is demonstrated to specify the effect of proposed system.

  19. Fuzzy dynamic output feedback H∞ control for continuous-time T-S fuzzy systems under imperfect premise matching.

    Science.gov (United States)

    Zhao, Tao; Dian, Songyi

    2017-09-01

    This paper addresses a fuzzy dynamic output feedback H ∞ control design problem for continuous-time nonlinear systems via T-S fuzzy model. The stability of the fuzzy closed-loop system which is formed by a T-S fuzzy model and a fuzzy dynamic output feedback H ∞ controller connected in a closed loop is investigated with Lyapunov stability theory. The proposed fuzzy controller does not share the same membership functions and number of rules with T-S fuzzy systems, which can enhance design flexibility. A line-integral fuzzy Lyapunov function is utilized to derive the stability conditions in the form of linear matrix inequalities (LMIs). The boundary information of membership functions is considered in the stability analysis to reduce the conservativeness of the imperfect premise matching design technique. Two simulation examples are provided to demonstrate the effectiveness of the proposed approach. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  20. Improved Approach to Robust Control for Type-2 T-S Fuzzy Systems

    Directory of Open Access Journals (Sweden)

    Bum Yong Park

    2018-01-01

    Full Text Available This paper is concerned with the robust stability conditions to stabilize the type 2 Takagi-Sugeno (T-S fuzzy systems. The conditions effectively handle parameter uncertainties using lower and upper membership functions. To improve the solvability of the stability conditions, we establish a multigain controller with comprehensive information of the lower and upper membership grades. In addition, a well-organized relaxation technique is proposed to fully exploit relationship among fuzzy weighting functions and their lower and upper membership grades, which enlarges a set of feasible solutions. Therefore, we derive a less conservative stabilization condition in terms of linear matrix inequalities (LMIs than those in the literature. Two simulation examples illustrate the effectiveness and robustness of the derived stabilization conditions.

  1. Risk based definition of TS requirements for NPPs with WWER-1000 type reactor

    International Nuclear Information System (INIS)

    Morozov, V.; Tokmachev, G.

    2000-01-01

    The main regulations in safety related maintenance for NPPs in Russia are defined as a part of Technical Specifications (TSs). It includes limiting conditions for operation (surveillance requirements, allowed outage time, et.). In Russian practice the two levels of TSs are presented: general TSs that have been established as a master documents for similar designed NPPs and plant specific based on operation practice of each NPP unit. This paper presents a brief review of submissions to TS changes for NPPs with WWER type reactor were issued by AEP PSA team since 1988 year. Besides it provides an approach allows to estimate the complex affect on plant risk for both Limiting Conditions of Operation (LCO) and Surveillance Test Intervals (STI) based on relevant probabilistic tool (Minimal Cut Sets method and Marcov Chains methods). (author)

  2. Improved Results on Fuzzy H∞ Filter Design for T-S Fuzzy Systems

    Directory of Open Access Journals (Sweden)

    Jiyao An

    2010-01-01

    Full Text Available The fuzzy H∞ filter design problem for T-S fuzzy systems with interval time-varying delay is investigated. The delay is considered as the time-varying delay being either differentiable uniformly bounded with delay derivative in bounded interval or fast varying (with no restrictions on the delay derivative. A novel Lyapunov-Krasovskii functional is employed and a tighter upper bound of its derivative is obtained. The resulting criterion thus has advantages over the existing ones since we estimate the upper bound of the derivative of Lyapunov-Krasovskii functional without ignoring some useful terms. A fuzzy H∞ filter is designed to ensure that the filter error system is asymptotically stable and has a prescribed H∞ performance level. An improved delay-derivative-dependent condition for the existence of such a filter is derived in the form of linear matrix inequalities (LMIs. Finally, numerical examples are given to show the effectiveness of the proposed method.

  3. Adaptive synchronization of T-S fuzzy chaotic systems with unknown parameters

    International Nuclear Information System (INIS)

    Kim, Jae-Hun; Park, Chang-Woo; Kim, Euntai; Park, Mignon

    2005-01-01

    This paper presents a fuzzy model-based adaptive approach for synchronization of chaotic systems which consist of the drive and response systems. Takagi-Sugeno (T-S) fuzzy model is employed to represent the chaotic drive and response systems. Since the parameters of the drive system are assumed unknown, we design the response system that estimates the parameters of the drive system by adaptive strategy. The adaptive law is derived to estimate the unknown parameters and its stability is guaranteed by Lyapunov stability theory. In addition, the controller in the response system contains two parts: one part that can stabilize the synchronization error dynamics and the other part that estimates the unknown parameters. Numerical examples, including Duffing oscillator and Lorenz attractor, are given to demonstrate the validity of the proposed adaptive synchronization approach

  4. HAfTs are novel lncRNA transcripts from aflatoxin exposure.

    Directory of Open Access Journals (Sweden)

    B Alex Merrick

    Full Text Available The transcriptome can reveal insights into precancer biology. We recently conducted RNA-Seq analysis on liver RNA from male rats exposed to the carcinogen, aflatoxin B1 (AFB1, for 90 days prior to liver tumor onset. Among >1,000 differentially expressed transcripts, several novel, unannotated Cufflinks-assembled transcripts, or HAfTs (Hepatic Aflatoxin Transcripts were found. We hypothesized PCR-cloning and RACE (rapid amplification of cDNA ends could further HAfT identification. Sanger data was obtained for 6 transcripts by PCR and 16 transcripts by 5'- and 3'-RACE. BLAST alignments showed, with two exceptions, HAfT transcripts were lncRNAs, >200nt without apparent long open reading frames. Six rat HAfT transcripts were classified as 'novel' without RefSeq annotation. Sequence alignment and genomic synteny showed each rat lncRNA had a homologous locus in the mouse genome and over half had homologous loci in the human genome, including at least two loci (and possibly three others that were previously unannotated. While HAfT functions are not yet clear, coregulatory roles may be possible from their adjacent orientation to known coding genes with altered expression that include 8 HAfT-gene pairs. For example, a unique rat HAfT, homologous to Pvt1, was adjacent to known genes controlling cell proliferation. Additionally, PCR and RACE Sanger sequencing showed many alternative splice variants and refinements of exon sequences compared to Cufflinks assembled transcripts and gene prediction algorithms. Presence of multiple splice variants and short tandem repeats found in some HAfTs may be consequential for secondary structure, transcriptional regulation, and function. In summary, we report novel, differentially expressed lncRNAs after exposure to the genotoxicant, AFB1, prior to neoplastic lesions. Complete cloning and sequencing of such transcripts could pave the way for a new set of sensitive and early prediction markers for chemical

  5. Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome.

    Directory of Open Access Journals (Sweden)

    Md Mahiuddin Ahmed

    Full Text Available Down syndrome (DS is caused by an extra copy of human chromosome 21 (Hsa21. Although it is the most common genetic cause of intellectual disability (ID, there are, as yet, no effective pharmacotherapies. The Ts65Dn mouse model of DS is trisomic for orthologs of ∼55% of Hsa21 classical protein coding genes. These mice display many features relevant to those seen in DS, including deficits in learning and memory (L/M tasks requiring a functional hippocampus. Recently, the N-methyl-D-aspartate (NMDA receptor antagonist, memantine, was shown to rescue performance of the Ts65Dn in several L/M tasks. These studies, however, have not been accompanied by molecular analyses. In previous work, we described changes in protein expression induced in hippocampus and cortex in control mice after exposure to context fear conditioning (CFC, with and without memantine treatment. Here, we extend this analysis to Ts65Dn mice, measuring levels of 85 proteins/protein modifications, including components of MAP kinase and MTOR pathways, and subunits of NMDA receptors, in cortex and hippocampus of Ts65Dn mice after failed learning in CFC and after learning was rescued by memantine. We show that, compared with wild type littermate controls, (i of the dynamic responses seen in control mice in normal learning, >40% also occur in Ts65Dn in failed learning or are compensated by baseline abnormalities, and thus are considered necessary but not sufficient for successful learning, and (ii treatment with memantine does not in general normalize the initial protein levels but instead induces direct and indirect responses in approximately half the proteins measured and results in normalization of the endpoint protein levels. Together, these datasets provide a first view of the complexities associated with pharmacological rescue of learning in the Ts65Dn. Extending such studies to additional drugs and mouse models of DS will aid in identifying pharmacotherapies for effective

  6. A Novel Secretory Poly-Cysteine and Histidine-Tailed Metalloprotein (Ts-PCHTP) from Trichinella spiralis (Nematoda)

    Science.gov (United States)

    Radoslavov, Georgi; Jordanova, Rositsa; Teofanova, Denitsa; Georgieva, Katya; Hristov, Petar; Salomone-Stagni, Marco; Liebau, Eva; Bankov, Ilia

    2010-01-01

    Background Trichinella spiralis is an unusual parasitic intracellular nematode causing dedifferentiation of the host myofiber. Trichinella proteomic analyses have identified proteins that act at the interface between the parasite and the host and are probably important for the infection and pathogenesis. Many parasitic proteins, including a number of metalloproteins are unique for the nematodes and trichinellids and therefore present good targets for future therapeutic developments. Furthermore, detailed information on such proteins and their function in the nematode organism would provide better understanding of the parasite - host interactions. Methodology/Principal Findings In this study we report the identification, biochemical characterization and localization of a novel poly-cysteine and histidine-tailed metalloprotein (Ts-PCHTP). The native Ts-PCHTP was purified from T. spiralis muscle larvae that were isolated from infected rats as a model system. The sequence analysis showed no homology with other proteins. Two unique poly-cysteine domains were found in the amino acid sequence of Ts-PCHTP. This protein is also the first reported natural histidine tailed protein. It was suggested that Ts-PCHTP has metal binding properties. Total Reflection X-ray Fluorescence (TXRF) assay revealed that it binds significant concentrations of iron, nickel and zinc at protein:metal ratio of about 1∶2. Immunohistochemical analysis showed that the Ts-PCHTP is localized in the cuticle and in all tissues of the larvae, but that it is not excreted outside the parasite. Conclusions/Significance Our data suggest that Ts-PCHTP is the first described member of a novel nematode poly-cysteine protein family and its function could be metal storage and/or transport. Since this protein family is unique for parasites from Superfamily Trichinelloidea its potential applications in diagnostics and treatment could be exploited in future. PMID:20967224

  7. A novel secretory poly-cysteine and histidine-tailed metalloprotein (Ts-PCHTP from Trichinella spiralis (Nematoda.

    Directory of Open Access Journals (Sweden)

    Georgi Radoslavov

    Full Text Available BACKGROUND: Trichinella spiralis is an unusual parasitic intracellular nematode causing dedifferentiation of the host myofiber. Trichinella proteomic analyses have identified proteins that act at the interface between the parasite and the host and are probably important for the infection and pathogenesis. Many parasitic proteins, including a number of metalloproteins are unique for the nematodes and trichinellids and therefore present good targets for future therapeutic developments. Furthermore, detailed information on such proteins and their function in the nematode organism would provide better understanding of the parasite-host interactions. METHODOLOGY/PRINCIPAL FINDINGS: In this study we report the identification, biochemical characterization and localization of a novel poly-cysteine and histidine-tailed metalloprotein (Ts-PCHTP. The native Ts-PCHTP was purified from T. spiralis muscle larvae that were isolated from infected rats as a model system. The sequence analysis showed no homology with other proteins. Two unique poly-cysteine domains were found in the amino acid sequence of Ts-PCHTP. This protein is also the first reported natural histidine tailed protein. It was suggested that Ts-PCHTP has metal binding properties. Total Reflection X-ray Fluorescence (TXRF assay revealed that it binds significant concentrations of iron, nickel and zinc at protein:metal ratio of about 1:2. Immunohistochemical analysis showed that the Ts-PCHTP is localized in the cuticle and in all tissues of the larvae, but that it is not excreted outside the parasite. CONCLUSIONS/SIGNIFICANCE: Our data suggest that Ts-PCHTP is the first described member of a novel nematode poly-cysteine protein family and its function could be metal storage and/or transport. Since this protein family is unique for parasites from Superfamily Trichinelloidea its potential applications in diagnostics and treatment could be exploited in future.

  8. Biochemical Characterization and Validation of a Catalytic Site of a Highly Thermostable Ts2631 Endolysin from the Thermus scotoductus Phage vB_Tsc2631

    OpenAIRE

    Plotka, Magdalena; Kaczorowska, Anna-Karina; Morzywolek, Agnieszka; Makowska, Joanna; Kozlowski, Lukasz P.; Thorisdottir, Audur; Skírnisdottir, Sigurlaug; Hjörleifsdottir, Sigridur; Fridjonsson, Olafur H.; Hreggvidsson, Gudmundur O.; Kristjansson, Jakob K.; Dabrowski, Slawomir; Bujnicki, Janusz M.; Kaczorowski, Tadeusz

    2015-01-01

    Phage vB_Tsc2631 infects the extremophilic bacterium Thermus scotoductus MAT2631 and uses the Ts2631 endolysin for the release of its progeny. The Ts2631 endolysin is the first endolysin from thermophilic bacteriophage with an experimentally validated catalytic site. In silico analysis and computational modelling of the Ts2631 endolysin structure revealed a conserved Zn2+ binding site (His30, Tyr58, His131 and Cys139) similar to Zn2+ binding site of eukaryotic peptidoglycan recognition protei...

  9. La grossesse chez l'adolescente à l'hôpital de Tsévié (Togo ...

    African Journals Online (AJOL)

    Objectif : Décrire le profil des grossesses chez l'adolescente à l'hôpital de Tsévié (Togo). Matériel et méthode : Il s'agissait d'une étude descriptive analytique portant sur les dossiers des parturientes âgées de 10 à 19 ans reçues à l'hôpital de Tsévié entre janvier 2011 et juin 2012. Résultats : Au cours de cette période, 180 ...

  10. Conceptual Study of the LB/TS (Large Blast/Thermal Simulator) Instrumentation, Data Acquisition and Facility Controls System.

    Science.gov (United States)

    1984-09-12

    AD-RI66 252 CONCEPTUAL STUDY OF THE LB /TS (LARGE BLAST/THERNL 1/3 d6n SIMULATOR) INSTRUNENT.. (U) SVERDRUP TECHNOLOGY INC TULLAHOMA TN R F STARR...HITIflN H[ -I H 1"t6 " r.. " A- DNA-TR-84-340 CONCEPTUAL STUDY OF THE LB /TS INSTRUMENTATION, "w DATA ACQUISITION AND FACILITY CONTROLS SYSTEM Lfl co...1986 la REPORT SECURITY CLASSIFICATION lb RESTRICTIVE MARKINGS UNCLASSIFIED 2a. SECURITY CLASSIFICATION AUTHORITY 3 DISTRIBUTION iAVAILAILITY OF REPORT

  11. Método predictivo de volatilidad tipo cambio

    Directory of Open Access Journals (Sweden)

    Jeffrey Viales Abellán

    2011-01-01

    Full Text Available Las series temporales descritas por precios de ciertos activos financieros tales como el de las acciones y divisas presentan dos principales características, excesos de kurtosis y clustering de volatilidad. Para recoger estas características se han utilizado modelos no lineales tales como los modelos Garch o Volatilidad Condicionada y los modelos de Volatilidad Estocástica, ambos tipos de modelo son empleados para la gestión del riesgo cambiario a corto plazo; el primer tipo de modelos definen la volatilidad en función de la misma volatilidad rezagada y de los shocks (innovaciones de volatilidad; el segundo tipo de modelos son similares a los modelos Garch con la variante de que la volatilidad incluye por si misma un término aleatorio de tipo proceso Wienner2; estos modelos son empleados para simular caminatas aleatorias del tipo de cambio con volatilidades simuladas por las ecuación estocásticas de volatilidad.En el presente trabajo se analizará el desempeño del modelo Garch en comparación a las medidas de volatilidad utilizadas actualmente para la gestión del riesgo cambiario; sus implicaciones para la gestión de riesgos.

  12. Hipnose e glicemia em pacientes com diabetes Mellitus tipo 1

    OpenAIRE

    Rodrigues, Fabiana Raquel Oliveira

    2016-01-01

    A Diabetes Mellitus tipo 1 é uma doença crónica, de elevado risco de mortalidade e elevada morbilidade que acarreta consequências precoces na saúde e na vida dos diabéticos. A presente investigação pretende averiguar a eficiência da hipnoterapia analítica, numa abordagem centrada na Pessoa e focada nas soluções que designamos por HSH - Hipnoterapia Sem (ou com) Hipnose, e da Visualização Guiada e Criativa, na monitorização da Diabetes Mellitus tipo 1 (glicemia e hemoglobina glicosilada). Para...

  13. La Planta única como tipo resistente a la escala

    OpenAIRE

    Colmenares Vilata, Silvia

    2014-01-01

    El sistema capitalista ha generado dos de los modelos espaciales de indiferencia funcional más extremos: por un lado, el espacio tecnificado y repetido del edificio de oficinas en altura, encarnado por la ?planta tipo? y, por otro, el espacio diáfano y extenso del gran contendor, que responde a la lógica de lo que llamaremos ?planta única?. En los edificios construidos para la industria automovilística y bélica americana se encuentra el germen de un tipo que servirá de modelo para los nuevos ...

  14. VISIT-TS: A multimedia tool for population studies on tic disorders [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    M. Jonathan Vachon

    2016-10-01

    Full Text Available Population-based assessment of Tourette syndrome (TS and other tic disorders produces a paradox. On one hand, ideally diagnosis of tic disorders requires expert observation. In fact, diagnostic criteria for TS explicitly require expert assessment of tics for a definite diagnosis. On the other hand, large-scale population surveys with expert assessment of every subject are impracticable. True, several published studies have successfully used expert assessment to find tic prevalence in a representative population (e.g. all students in a school district. However, extending these studies to larger populations is daunting. We created a multimedia tool to demonstrate tics to a lay audience, discuss their defining and common attributes, and address features that differentiate tics from other movements and vocalizations. A first version was modified to improve clarity and to include a more diverse group in terms of age and ethnicity. The result is a tool intended for epidemiological research. It may also provide additional benefits, such as more representative minority recruitment for other TS studies and increased community awareness of TS.

  15. Benefits and Factors Influencing the Design of Intergenerational Digital Games: A Systematic Literature Review

    NARCIS (Netherlands)

    de la Hera Conde-Pumpido, T.; Loos, E.F.; Simons, M.; Blom, J.

    2017-01-01

    The main purpose of this paper is to review the benefits and factors to be taken into consideration for the design of intergenerational digital games. We conducted a systematic in Scopus, Web of Science, PsicInfo, Pubmed and Science Direct, finally including 16 empirical studies written in English.

  16. A Universal Ts-VI Triangle Method for the Continuous Retrieval of Evaporative Fraction From MODIS Products

    Science.gov (United States)

    Zhu, Wenbin; Jia, Shaofeng; Lv, Aifeng

    2017-10-01

    The triangle method based on the spatial relationship between remotely sensed land surface temperature (Ts) and vegetation index (VI) has been widely used for the estimates of evaporative fraction (EF). In the present study, a universal triangle method was proposed by transforming the Ts-VI feature space from a regional scale to a pixel scale. The retrieval of EF is only related to the boundary conditions at pixel scale, regardless of the Ts-VI configuration over the spatial domain. The boundary conditions of each pixel are composed of the theoretical dry edge determined by the surface energy balance principle and the wet edge determined by the average air temperature of open water. The universal triangle method was validated using the EF observations collected by the Energy Balance Bowen Ratio systems in the Southern Great Plains of the United States of America (USA). Two parameterization schemes of EF were used to demonstrate their applicability with Terra Moderate Resolution Imaging Spectroradiometer (MODIS) products over the whole year 2004. The results of this study show that the accuracy produced by both of these two parameterization schemes is comparable to that produced by the traditional triangle method, although the universal triangle method seems specifically suited to the parameterization scheme proposed in our previous research. The independence of the universal triangle method from the Ts-VI feature space makes it possible to conduct a continuous monitoring of evapotranspiration and soil moisture. That is just the ability the traditional triangle method does not possess.

  17. Structure/function relationship studies on the T/S residues 173-177 of rat ODC.

    Science.gov (United States)

    Matés, J M; del Valle, A E; Urdiales, J L; Coleman, C S; Feith, D; Olmo, M T; Pegg, A E; Sánchez-Jiménez, F

    1998-07-28

    A well-conserved T/S cluster was detected among vertebrate ornithine decarboxylase by computer analysis (E. Viguera, O. Trelles, J.L. Urdiales, J.M. Matés, F. Sánchez-Jiménez, Trends Biochem. Sci. 19 (1994) 318-319). In the present report we studied the role of these residues (173, 176 and 177 in rat ornithine decarboxylase (ODC)) in enzymic activity and stability by in vitro expression, kinetic characterization and in vitro degradation of site-directed mutants. These T/S residues are substituted by a D/E-enriched fragment in other lower eukaryotic ODCs. The substitution of the T/S-enriched fragment (TLKTS) of rat ODC by the negative charged fragment of T. brucei ODC (KVEDC) did not affect protein stability, but increased Km values of the mutant enzyme. The substitution of the T/S residues by alanine also has a similar effect on rat ODC kinetic values. However, results indicate that polarity of the fragment must be an important factor for protein conformation, since the latter mutant, having no T/S or D/E residue in the fragment (ALKAA), showed reduced stability in vitro.

  18. Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins

    Science.gov (United States)

    Cremonez, Caroline M.; Maiti, Mohitosh; Peigneur, Steve; Cassoli, Juliana Silva; Dutra, Alexandre A. A.; Waelkens, Etienne; Lescrinier, Eveline; Herdewijn, Piet; de Lima, Maria Elena; Pimenta, Adriano M. C.; Arantes, Eliane C.; Tytgat, Jan

    2016-01-01

    To date, several families of peptide toxins specifically interacting with ion channels in scorpion venom have been described. One of these families comprise peptide toxins (called KTxs), known to modulate potassium channels. Thus far, 202 KTxs have been reported, belonging to several subfamilies of KTxs (called α, β, γ, κ, δ, and λ-KTxs). Here we report on a previously described orphan toxin from Tityus serrulatus venom, named Ts11. We carried out an in-depth structure-function analysis combining 3D structure elucidation of Ts11 and electrophysiological characterization of the toxin. The Ts11 structure is highlighted by an Inhibitor Cystine Knot (ICK) type scaffold, completely devoid of the classical secondary structure elements (α-helix and/or β-strand). This has, to the best of our knowledge, never been described before for scorpion toxins and therefore represents a novel, 6th type of structural fold for these scorpion peptides. On the basis of their preferred interaction with voltage-gated K channels, as compared to all the other targets tested, it can be postulated that Ts11 is the first member of a new subfamily, designated as ε-KTx. PMID:27706049

  19. A novel concurrent chemoradiotherapy with TS-1/nedaplatin for esophageal cancer showing better quality of life durning treatment

    International Nuclear Information System (INIS)

    Miyazaki, Aya; Inaba, Hiroyuki; Tsuda, Takashi; Itoh, Fumio

    2005-01-01

    Concurrent chemoradiotherapy (CRT) for esophageal cancer is expected to achieve adequate quality of life (QOL) and to improve the survival of patients. As a QOL-oriented therapy for esophageal cancer, concurrent CRT with tegafur·gimestat·otastat potassium (TS-1)/nedaplatin (CDGP) was developed and evaluated. Between June 2001 and September 2002, 18 patients with esophageal cancer were enrolled in a clinical study of concurrent CRT with TS-1/CDGP. To evaluate the impact of treatment on the QOL, the patients were asked to answer QOL Questionnaire for Cancer Patients Treated with Anticancer Drugs (QOL-ACD) before and after therapy. The response rate was 66.7%, with a complete response occurring in 9 (50.0%) of the 18 patients. Patients with improved global, functional, or mental QOL after therapy showed or tended to show a significant, longer survival. Compared to patients previously treated by the same regimen with 5-fluorouracil (5-FU) instead of TS-1, those receiving the present therapy were able to leave hospital more frequently during treatment. TS-1/CDGP-based CRT for esophageal cancer exhibited comparable antitumor activity and survival benefit as with standard 5-FU/cisplatin (CDDP)-based CRT without causing serious side-effects. The patients receiving the present therapy seemed to have a better chance of maintaining their QOL. (author)

  20. NeemAzal T/S – toxicity to early-life stages of common carp (Cyprinus carpio L.)

    Czech Academy of Sciences Publication Activity Database

    Chromcová, L.; Blahová, J.; Živná, D.; Plhalová, L.; Casuscelli di Tocco, F.; Divišová, L.; Prokeš, Miroslav; Faggio, C.; Tichý, F.; Svobodová, Z.

    2015-01-01

    Roč. 60, č. 1 (2015), s. 23-30 ISSN 0375-8427 Institutional support: RVO:68081766 Keywords : Neemazal T/S * embryo-larval toxicity test * azadirachtin * oxidative stress * histopathology * insecticide Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine Impact factor: 0.560, year: 2015

  1. DESEMPENHO DE GENÓTIPOS DE MILHO (Zea mays l. SUBMETIDOS A DOIS TIPOS DE ADUBAÇÃO

    Directory of Open Access Journals (Sweden)

    Paulo Ricardo dos Santos

    2014-06-01

    Full Text Available O presente trabalho teve como objetivo avaliar o desempenho de quatro genótipos de milho (Viçosense, Branca e Rio Largo; e uma variedade comercial desenvolvida pela Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA, BR 106 submetidas a dois tipos de adubação (orgânica e química no Município de Rio Largo-Alagoas. O delineamento experimental usado foi em blocos casualizado, com três repetições no esquema fatorial (4 x 2. Estudaram-se as variáveis: tamanho da espiga (TE, em cm; diâmetro de espigas (DE, em cm; número de fileiras por espigas (NFP, em unidades; peso de 100 grãos (PG 100, em g; altura de inserção da 1ª espiga (AIP, em cm; altura de plantas (AP em cm e rendimento de grãos (RG, em t.ha-1. Para variável Rendimento de Grãos não se identificou diferença significativa entre os genótipos avaliados, no qual apresentou valor médio de 5103,90 t ha-1. Tais resultados demonstram a potencialidade dos genótipos desenvolvidos pelo SMGP-CECA/UFAL, e da variedade BR 106 lançada pela EMBRAPA, pois superaram a média alagoana e brasileira no rendimento de grãos. Os tipos de adubação apresentaram uma média 5103,9 t ha-1, não apresentando diferenças significativas entre si. O genótipo Rio Largo apresentou os melhores resultados para peso de cem grãos (33,65 g, altura de inserção da primeira espiga (147,67 cm e juntamente com o genótipo Branca obtiveram as maiores alturas de plantas, respectivamente, 276,67 cm e 270,5 cm. A Variedade BR 106 obteve o maior número de fileiras por espiga (14,35 un e a menor altura de inserção da primeira espiga (79,33 cm e ao lado do genótipo Viçosense os menores peso de cem grãos, respectivamente, 28,6 g e 29,13 g.

  2. TsHKT1;2, a HKT1 homolog from the extremophile Arabidopsis relative Thellungiella salsuginea, shows K(+) specificity in the presence of NaCl.

    Science.gov (United States)

    Ali, Zahir; Park, Hyeong Cheol; Ali, Akhtar; Oh, Dong-Ha; Aman, Rashid; Kropornicka, Anna; Hong, Hyewon; Choi, Wonkyun; Chung, Woo Sik; Kim, Woe-Yeon; Bressan, Ray A; Bohnert, Hans J; Lee, Sang Yeol; Yun, Dae-Jin

    2012-03-01

    Cellular Na(+)/K(+) ratio is a crucial parameter determining plant salinity stress resistance. We tested the function of plasma membrane Na(+)/K(+) cotransporters in the High-affinity K(+) Transporter (HKT) family from the halophytic Arabidopsis (Arabidopsis thaliana) relative Thellungiella salsuginea. T. salsuginea contains at least two HKT genes. TsHKT1;1 is expressed at very low levels, while the abundant TsHKT1;2 is transcriptionally strongly up-regulated by salt stress. TsHKT-based RNA interference in T. salsuginea resulted in Na(+) sensitivity and K(+) deficiency. The athkt1 mutant lines overexpressing TsHKT1;2 proved less sensitive to Na(+) and showed less K(+) deficiency than lines overexpressing AtHKT1. TsHKT1;2 ectopically expressed in yeast mutants lacking Na(+) or K(+) transporters revealed strong K(+) transporter activity and selectivity for K(+) over Na(+). Altering two amino acid residues in TsHKT1;2 to mimic the AtHKT1 sequence resulted in enhanced sodium uptake and loss of the TsHKT1;2 intrinsic K(+) transporter activity. We consider the maintenance of K(+) uptake through TsHKT1;2 under salt stress an important component supporting the halophytic lifestyle of T. salsuginea.

  3. MIS High-Purity Plutonium Oxide Metal Oxidation Product TS707001 (SSR123): Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Veirs, Douglas Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Stroud, Mary Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Berg, John M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Narlesky, Joshua Edward [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Worl, Laura Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Martinez, Max A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Carillo, Alex [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-09

    A high-purity plutonium dioxide material from the Material Identification and Surveillance (MIS) Program inventory has been studied with regard to gas generation and corrosion in a storage environment. Sample TS707001 represents process plutonium oxides from several metal oxidation operations as well as impure and scrap plutonium from Hanford that are currently stored in 3013 containers. After calcination to 950°C, the material contained 86.98% plutonium with no major impurities. This study followed over time, the gas pressure of a sample with nominally 0.5 wt% water in a sealed container with an internal volume scaled to 1/500th of the volume of a 3013 container. Gas compositions were measured periodically over a six year period. The maximum observed gas pressure was 138 kPa. The increase over the initial pressure of 80 kPa was primarily due to generation of nitrogen and carbon dioxide gas in the first six months. Hydrogen and oxygen were minor components of the headspace gas. At the completion of the study, the internal components of the sealed container showed signs of corrosion, including pitting.

  4. Trapping or tethering stones (TS: A multifunctional device in the Pastoral Neolithic of the Sahara.

    Directory of Open Access Journals (Sweden)

    Marina Gallinaro

    Full Text Available The Pierres de Ben Barour, also known as trapping or tethering stones (TS, are stone artefacts with notches or grooves usually interpreted as hunting devices on the basis of rock art engravings. Though their presence is a peculiar feature of desert landscapes from the Sahara to the Arabian Peninsula, we know little about their age, context and function. Here we present a new approach to the study of these artefacts based on a large dataset (837 items recorded in the Messak plateau (SW Libya. A statistically-based geoarchaeological survey carried out between 2007 and 2011 in Libya, alongside landscape and intra-site analyses of specific archaeological features (such as rock art, settlement and ceremonial contexts, reveal that these artefacts were used for a prolonged period, probably from the early Holocene. This was followed by a multifunctional use of these devices, particularly during the Pastoral Neolithic phase (ca. 6400-3000 cal BC, with the highest concentrations being found near ceremonial contexts related to cattle burials.

  5. Adenylylation of small RNA sequencing adapters using the TS2126 RNA ligase I.

    Science.gov (United States)

    Lama, Lodoe; Ryan, Kevin

    2016-01-01

    Many high-throughput small RNA next-generation sequencing protocols use 5' preadenylylated DNA oligonucleotide adapters during cDNA library preparation. Preadenylylation of the DNA adapter's 5' end frees from ATP-dependence the ligation of the adapter to RNA collections, thereby avoiding ATP-dependent side reactions. However, preadenylylation of the DNA adapters can be costly and difficult. The currently available method for chemical adenylylation of DNA adapters is inefficient and uses techniques not typically practiced in laboratories profiling cellular RNA expression. An alternative enzymatic method using a commercial RNA ligase was recently introduced, but this enzyme works best as a stoichiometric adenylylating reagent rather than a catalyst and can therefore prove costly when several variant adapters are needed or during scale-up or high-throughput adenylylation procedures. Here, we describe a simple, scalable, and highly efficient method for the 5' adenylylation of DNA oligonucleotides using the thermostable RNA ligase 1 from bacteriophage TS2126. Adapters with 3' blocking groups are adenylylated at >95% yield at catalytic enzyme-to-adapter ratios and need not be gel purified before ligation to RNA acceptors. Experimental conditions are also reported that enable DNA adapters with free 3' ends to be 5' adenylylated at >90% efficiency. © 2015 Lama and Ryan; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  6. The Epoxidation of Limonene over the TS-1 and Ti-SBA-15 Catalysts

    Directory of Open Access Journals (Sweden)

    Agnieszka Wróblewska

    2014-11-01

    Full Text Available Limonene belongs to a group of very important intermediates used in the production of fine chemicals. This monoterpene compound can be obtained from peels of oranges or lemon which are a (biomass waste from the orange juice industry. Thus, limonene is a renewable, easy available and a relatively cheap compound. This work presents preliminary studies on the process of limonene epoxidation over zeolite type catalysts such as: TS-1 and Ti-SBA-15. In these studies methanol was used as a solvent and as an oxidizing agent a 60 wt % hydrogen peroxide solution was applied. The activity of each catalyst was investigated for four chosen temperatures (0 °C, 40 °C, 80 °C and 120 °C. The reaction time was changed from 0.5 to 24 h. For each catalyst the most beneficial conditions (the appropriate temperature and the reaction time have been established. The obtained results were compared and the most active catalyst was chosen. These studies have also shown different possible ways of limonene transformation, not only in the direction of 1,2-epoxylimonene and its corresponding diol, but also in direction of carveol, carvone and perillyl alcohol—compounds with a lot of applications. The possible mechanisms of formation of the allylic oxidation products were proposed.

  7. Event-triggered fault detection for discrete-time T-S fuzzy systems.

    Science.gov (United States)

    Wang, Xiao-Lei; Yang, Guang-Hong

    2018-03-01

    This paper is concerned with the design of piecewise fuzzy diagnostic observers for discrete-time T-S fuzzy systems under an event-triggered (ET) communication mechanism. Considering that the premise variables of the fuzzy diagnostic observer and the system may belong to different local space regions due to the introduction of ET mechanism, a partition method-based piecewise fuzzy diagnostic observer is designed to detect faults. The two-term approximation approach is introduced to approximate the time-varying delay. By transforming the augmented system into an input-output form consisting of two interconnected subsystems, the design condition of the piecewise fuzzy diagnostic observer is obtained by using the scaled small gain (SSG) theorem and a piecewise Lyapunov-Krasovskii functional. Furthermore, the L ∞ /L 2 and L ∞ fault detection (FD) scheme is used to optimize the FD performance. Finally, two simulation examples are provided to show the efficiency of the proposed design method. Copyright © 2018 ISA. Published by Elsevier Ltd. All rights reserved.

  8. TS07D Empirical Geomagnetic Field Model as a Space Weather Tool

    Science.gov (United States)

    Sharp, N. M.; Stephens, G. K.; Sitnov, M. I.

    2011-12-01

    Empirical modeling and forecasting of the geomagnetic field is a key element of the space weather research. A dramatic increase in the number of data available for the terrestrial magnetosphere required a new generation of empirical models with large numbers of degrees of freedom and sophisticated data-mining techniques. A set of the corresponding data binning, fitting and visualization procedures known as the TS07D model is now available at \\url{http://geomag_field.jhuapl.edu/model/} and it is used for detailed investigation of storm-scale phenomena in the magnetosphere. However, the transformation of this research model into a practical space weather application, which implies its extensive running for validation and interaction with other space weather codes, requires its presentation in the form of a single state-of-the-art code, well documented and optimized for the highest performance. To this end, the model is implemented in the Java programming language with extensive self-sufficient library and a set of optimization tools, including multi-thread operations that assume the use of the code in multi-core computers and clusters. The results of the new code validation and optimization of its binning, fitting and visualization parts are presented as well as some examples of the processed storms are discussed.

  9. Experiments in a boundary layer subjected to free stream turbulence. Part 2: The role of TS waves in the transition process

    International Nuclear Information System (INIS)

    Boiko, A.V.; Westin, K.J.A.; Klingmann, B.G.B.; Kozlov, V.V.; Alfredsson, P.H.

    1993-12-01

    The natural occurrence of Tollmien-Schlichting (TS) waves has so far only been observed in boundary layers subjected to moderate levels of free stream turbulence (Tu <1%), due to the difficulty in detecting small-amplitude waves in highly perturbed boundary layers. By introducing controlled oscillations with a vibrating ribbon, it is possible to study small amplitude waves using phase-selective filtering techniques. In the present work, the effect of TS-waves on the transition is studied at Tu = 1.5%. It is demonstrated that TS-waves can exist and develop in a similar way as in an undisturbed boundary layer. It is also found that TS-waves with quite small amplitudes are involved in nonlinear interactions which lead to a regeneration of TS-waves in the whole unstable frequency band. This results in a significant increase in the number of turbulent spots, which promote the onset of turbulence. 28 refs

  10. Interaction between paliperidone extended release and TS-1®, an oral anticancer drug containing a 5-fluorouracil derivative, in a schizophrenic patient

    Directory of Open Access Journals (Sweden)

    Yasui-Furukori N

    2013-03-01

    Full Text Available Norio Yasui-Furukori, Kojiro Hashimoto, Kazutoshi Kubo, Tetsu Tomita Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan Abstract: Until now there has been no information available on drug interaction between paliperidone and TS-1®, an oral anticancer drug containing a 5-fluorouracil derivative. The patient in the case presented here was a 39-year-old man with a 15-year history of schizophrenia. The patient's usual treatment of 2 mg/day of risperidone was changed to 3 mg/day of paliperidone extended release. He experienced worsening psychotic symptoms after switching from risperidone to paliperidone while he was also receiving TS-1. Retrospective analyses showed plasma concentration of paliperidone was consistently lower during the treatment with TS-1 than without TS-1. This case suggests there is drug interaction between paliperidone extended-release tablets and TS-1. Keywords: schizophrenia, antipsychotic, OROS, diarrhea, Positive and Negative Syndrome Scale

  11. Parâmetros de desempenho e carcaça de genótipos de frangos tipo caipira

    Directory of Open Access Journals (Sweden)

    R.C. Veloso

    2014-08-01

    Full Text Available Objetivou-se com este trabalho avaliar as características de desempenho e de carcaça de sete genótipos de frangos tipo caipira da linhagem Redbro. Foram utilizados 840 pintos de um dia, machos, distribuídos em delineamento inteiramente ao acaso, dos seguintes genótipos: Caboclo, Carijó, Colorpak, Gigante Negro, Pesadão Vermelho, Pescoço Pelado e Tricolor. Os frangos foram alojados em 28 boxes, sendo 30 frangos por boxe, em galpão de alvenaria com acesso a um piquete de 45m², em quatro repetições. As características de desempenho (conversão alimentar, ganho em peso médio diário, consumo de ração médio diário foram avaliadas nos períodos: um a 28, um a 56, um a 70 e um a 84 dias de idade. O peso corporal foi avaliado aos 28, 56, 70 e 84 dias de idade. As características de carcaça (peso e rendimento de carcaça, peito e pernas foram obtidas a partir do abate de dois frangos por boxe, aos 85 dias de idade. As análises estatísticas foram realizadas utilizando-se o "proc glm" do SAS. Verificou-se que, em todos os períodos, os frangos do genótipo Colorpak apresentaram maior peso corporal, consumo de ração médio diário, ganho em peso médio diário e melhor conversão alimentar. Entretanto, os genótipos Caboclo e Gigante Negro apresentaram menores consumo de ração médio diário, ganho de peso médio diário e pior conversão alimentar. Quanto ao rendimento de cortes, observou-se que os genótipos Caboclo e Gigante Negro apresentaram os menores valores, e o Carijó, Colorpak, Pesadão Vermelho, Pescoço Pelado e Tricolor obtiveram os melhores rendimentos de pernas. Para o rendimento de peito, o Carijó e o Pesadão Vermelho obtiveram os maiores valores. A escolha do genótipo deve ser feita de acordo com o interesse do mercado, pois há diferenças no desempenho e no rendimento de carcaça e dos cortes.

  12. CARACTERIZAÇÃO PÓS-COLHEITA E SENSORIAL DE GENÓTIPOS DE BANANEIRAS TIPO PRATA

    Directory of Open Access Journals (Sweden)

    ARIANE CASTRICINI

    2015-03-01

    Full Text Available RESUMO O norte de Minas Gerais é grande produtor de banana ‘Prata-Anã’ irrigada, cultura altamente suscetível ao Mal-do-Panamá. O uso de genótipos resistentes é uma alternativa, mas os frutos devem apresentar características pós-colheita o mais próximo possível da ‘Prata-Anã’, para melhor aceitação pelos consumidores. O objetivo do trabalho foi caracterizar frutos em pós-colheita, identificar a preferência e a intenção de compra de diferentes genótipos de bananeira tipo Prata. Os genótipos Prata-Anã, BRS Platina e Fhia-18. foram caracterizados no ponto de colheita (verdes e maduros (estádio seis de maturação, por avaliações químicas, físicas e sensoriais. Quando verde, ‘BRS Platina’ apresentou maior massa fresca e tamanho que ‘Fhia-18’ e ‘Prata-Anã’. ‘Fhia-18.’ teve a tonalidade verde da casca mais intensa que a dos demais genótipos. Madura, ‘BRS Platina’ foi mais firme, mas com a mesma resistência ao despencamento que ‘Fhia-18’ e superior à ‘Prata-Anã’. ‘Fhia-18’ apresentou cor da casca com amarelo mais clara e tão brilhante quanto da ‘Prata-Anã’, mas ‘BRS Platina’ teve a tonalidade de amarelo mais intensa. Bananas ‘Fhia-18’ foram mais ácidas, ‘BRS Platina’, com menor acidez titulável, e ‘Prata-Anã’, o maior teor de sólidos solúveis. Os genótipos Prata-Anã e BRS Platina tiveram maior preferência e intenção de compra pelos consumidores, sendo as bananas ‘Prata-Anã’ em dedos e ‘BRS Platina’ e ‘Fhia-18’ em dedos, buquê e penca, as mais preferidas. Entretanto, a maioria compraria bananas ‘Prata-Anã’ em buquê e ‘BRS Platina’ e ‘Fhia-18’ em penca. Enquanto verdes, os genótipos foram semelhantes à ‘Prata-Anã’, e maiores diferenças químicas e físicas ocorreram quando maduros.

  13. Tie-down assessment of radioactive material packages on conveyances approach to competent authority approval applications in accordance with TS-R 1 (June 2000) and TS-G-1.1 (June 2002)

    International Nuclear Information System (INIS)

    Read, J.; Owen, S.; Tso, C.F.

    2004-01-01

    This paper summarizes the authors' findings, during carrying out many package tie-down assessments, regarding the approach to the assessment process, and the issues that may arise. The current regulatory framework, as outlined in the abstract, is considered and possible areas for further development or research are discussed. The safe transport of a package containing radioactive material requires a secure system of retention on the conveyance during transport. The requirements for the assessment of this tie-down system are covered by International Atomic Energy Authority (IAEA) Regulations, and by the specific regulatory and guidance materials applying in the country of application. The IAEA regulations have recently been updated in TS-R-1 (June 2000) [1] and TS-G-1.1 (June 2002) [2]. In particular, Appendix V of reference [2] specifically covers 'Package Stowage and Retention during Transport'. In the United Kingdom the Transport Container Standardisation Committee (TCSC) provides guidance on the application of the IAEA regulations in TCSC 1006 ''The securing of Radioactive Materials on Conveyances'' [3], and this document has also been revised in December 2003. The basic requirement of the IAEA regulations is to maintain the integrity of the components of the package and its retention systems during routine operations (TS-R-1 Para 612). In accident conditions the package is permitted and may be required as part of the design (the weak-link approach as discussed later in this paper) to separate from the conveyance, while preserving the package integrity. Any tie-down attachments on the package shall be so designed that, under normal and accident conditions of transport, the forces in those attachments shall not impair the ability of the package to meet the requirements of the Regulations. (TS-R-1 Para 636)

  14. Nonmonotonic observer-based fuzzy controller designs for discrete time T-S fuzzy systems via LMI.

    Science.gov (United States)

    Derakhshan, Siavash Fakhimi; Fatehi, Alireza; Sharabiany, Mehrad Ghasem

    2014-12-01

    In this paper, based on the nonmonotonic Lyapunov functions, a new less conservative state feedback controller synthesis method is proposed for a class of discrete time nonlinear systems represented by Takagi-Sugeno (T-S) fuzzy systems. Parallel distributed compensation (PDC) state feedback is employed as the controller structure. Also, a T-S fuzzy observer is designed in a manner similar to state feedback controller design. The observer and the controller can be obtained separately and then combined together to form an output feedback controller by means of the Separation theorem. Both observer and controller are obtained via solving a sequence of linear matrix inequalities. Nonmonotonic Lyapunov method allows the design of controllers for the aforementioned systems where other methods fail. Illustrative examples are presented which show how the proposed method outperforms other methods such as common quadratic, piecewise or non quadratic Lyapunov functions.

  15. Switching off H2O2 Decomposition during TS-1 Catalysed Epoxidation via Post-Synthetic Active Site Modification

    Directory of Open Access Journals (Sweden)

    Ceri Hammond

    2015-12-01

    Full Text Available Despite its widespread use, the Lewis acidic zeolite, TS-1, still exhibits several unfavourable properties, such as excessive H2O2 decomposition, which decrease its overall performance. In this manuscript, we demonstrate that post-synthetic modification of TS-1 with aqueous NH4HF2 leads to modifications in epoxidation catalysis, which both improves the levels of epoxide selectivity obtained, and drastically minimises undesirable H2O2 decomposition. Through in situ spectroscopic study with UV-resonance enhanced Raman spectroscopy, we also observe a change in Ti site speciation, which occurs via the extraction of mononuclear [Ti(OSi4] atoms, and which may be responsible for the changes in observed activity.

  16. Robust fuzzy output feedback controller for affine nonlinear systems via T-S fuzzy bilinear model: CSTR benchmark.

    Science.gov (United States)

    Hamdy, M; Hamdan, I

    2015-07-01

    In this paper, a robust H∞ fuzzy output feedback controller is designed for a class of affine nonlinear systems with disturbance via Takagi-Sugeno (T-S) fuzzy bilinear model. The parallel distributed compensation (PDC) technique is utilized to design a fuzzy controller. The stability conditions of the overall closed loop T-S fuzzy bilinear model are formulated in terms of Lyapunov function via linear matrix inequality (LMI). The control law is robustified by H∞ sense to attenuate external disturbance. Moreover, the desired controller gains can be obtained by solving a set of LMI. A continuous stirred tank reactor (CSTR), which is a benchmark problem in nonlinear process control, is discussed in detail to verify the effectiveness of the proposed approach with a comparative study. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  17. Desenvolvimento experimental de um motor stirling tipo gama.

    OpenAIRE

    Cruz, Vinicius Guimarães da

    2012-01-01

    O presente trabalho consiste no desenvolvimento experimental de um motor Stirling tipo gama. São apresentadas inicialmente as diferentes configurações deste tipo de motor (alfa, gama e beta), a definição do ciclo de Stirling e a modelagem matemática para cada configuração. Uma análise matemática é feita através da teoria de Schmidt, que é um método baseado na compressão e expansão isotérmica de um gás ideal, implementada em programa computacional permitindo determinar a dependência entre os p...

  18. Vaciamiento gástrico y diabetes mellitus tipo 2

    Directory of Open Access Journals (Sweden)

    Camilo Andrés Quintero Cadavid

    2015-04-01

    Full Text Available El adecuado control de la diabetes mellitus tiene una gran importancia desde muchos puntos de vista. En los últimos años, se ha destacado el impacto que tienen los niveles de la glucemia postprandial sobre el manejo y las complicaciones de esta enfermedad. Controlar la hiperglucemia postprandial y, por lo tanto, su participación en el deterioro clínico de los pacientes con diabetes puede conseguirse retardando el vaciamiento gástrico y estimulando el efecto incretina, los cuales se pueden promover utilizando los análogos del péptido similar al glucagón tipo 1 (GLP-1. En este artículo se revisa el concepto del efecto incretina y la utilidad de los análogos GLP-1 en el control de la glicemia en los pacientes con diabetes mellitus tipo 2.

  19. Sobre la localidad tipo de Eunectes notaeus Cope (Serpentes: Boidae

    Directory of Open Access Journals (Sweden)

    Waller, Tomás

    2000-02-01

    Full Text Available Todas las revisiones han pasado por alto el hecho de que el mismo de la descripción, al detallar el catálogo de la colección realizada durante la expedición conducida por el Capitán T. J. Page en los ríos Paraná, Paraguay, Bermejo y Uruguay, E. D. Cope especifica claramente el lugar de procedencia del especimen tipo: "...No. 4707. Taken in the Paraguay River about thirty miles south of Fort Coimbra, Brazil, near lat. 20°S" (Cope, 1862b: 350. En definitiva, esta última debería ser considerada la localidad tipo de E. notaeus.

  20. Riesgo de tipo de cambio: cobertura con instrumentos financieros

    OpenAIRE

    Gutiérrez Blanco, Vidal

    2017-01-01

    RESUMEN: En el siguiente trabajo se hace una pequeña aproximación al mercado de divisas, explicando qué es el tipo de cambio y cuál es el riesgo que conlleva operar con monedas de diferentes países. En primer lugar, se define el mercado de divisas, poniendo énfasis sobre el hecho de que es el mercado más grande y líquido del mundo, y se identifican cuáles son las principales operaciones llevadas a cabo en este mercado. Seguidamente, se ha explicado lo que es el tipo de cambio, cuáles son l...

  1. A route to hydroxylfluorenes: TsOH-mediated condensation reactions of 1,3-diketones with propargylic alcohols

    KAUST Repository

    Yao, Liangfeng

    2012-01-01

    An efficient method of preparing hydroxylfluorenes by TsOH-mediated tandem alkylation/rearrangements of propargylic alcohols with 1,3-diketones is described. These reactions are accomplished in moderate to good yields under mild conditions to offer a straightforward and convenient one step synthetic route to hydroxylfluorene derivatives through a plausible mechanism involving a sequence of dehydration, addition, rearrangement and aromatization. This journal is © The Royal Society of Chemistry 2012.

  2. Expression profile analysis of vulnerable CA1 pyramidal neurons in young-middle aged Ts65Dn mice

    Science.gov (United States)

    Alldred, Melissa J.; Lee, Sang Han; Petkova, Eva; Ginsberg, Stephen D.

    2014-01-01

    Down syndrome (DS) is the most prevalent cause of intellectual disability (ID). Individuals with DS show a variety of cognitive deficits, most notably in hippocampal learning and memory, and display pathological hallmarks of Alzheimer's disease (AD), with neurodegeneration of cholinergic basal forebrain (CBF) neurons. Elucidation of the molecular and cellular underpinnings of neuropathology has been assessed via gene expression analysis in a relevant animal model, termed the Ts65Dn mouse. The Ts65Dn mouse is a segmental trisomy model of DS which mimics DS/AD pathology, notably age-related cognitive dysfunction and degeneration of basal forebrain cholinergic neurons (BFCNs). To determine expression level changes, molecular fingerprinting of Cornu Ammonis 1 (CA1) pyramidal neurons was performed in adult (4-9 month old) Ts65Dn mice, at the initiation of BFCN degeneration. To quantitate transcriptomic changes during this early time period, laser capture microdissection (LCM), terminal continuation (TC) RNA amplification, custom-designed microarray analysis, and subsequent validation of individual transcripts by qPCR and protein analysis via immunoblotting was performed. Results indicate significant alterations within CA1 pyramidal neurons of Ts65Dn mice compared to normal disomic (2N) littermates, notably in the downregulation of neurotrophins and their cognate neurotrophin receptors among other classes of transcripts relevant to neurodegeneration. These results of this single population gene expression analysis at the time of septohippocampal deficits in a trisomic mouse model shed light on a vulnerable circuit that may cause the AD-like pathology invariably seen in DS that could help to identify mechanisms of degeneration, and provide novel gene targets for therapeutic interventions. PMID:25131634

  3. LHC optics determination with proton tracks measured in the CT-PPS detectors in 2016, before TS2

    CERN Document Server

    Nemes, F

    2017-01-01

    Novel optics estimation methods have been developed for the CMS-TOTEM Precision Proton Spectrometer (CT-PPS), in order to determine the horizontal dispersion function $D_{x}$ and the orbit between IP5 and the Roman Pot detectors. The tools have been successfully applied at $\\sqrt{s} = $13 TeV collision energy and $\\beta^{*} = $0.4 m optics with $\\alpha = 370\\,\\mu$rad horizontal crossing angle (settings valid in 2016 before Technical Stop 2 - TS2).

  4. TS-BTPhen as a promising hydrophilic complexing agent for selective Am(III separation by solvent extraction

    Directory of Open Access Journals (Sweden)

    Kaufholz Peter

    2015-12-01

    Full Text Available The novel hydrophilic back-extraction agent TS-BTPhen (3,3ʹ,3ʺ,3ʹʺ-[3-(1,10-phenanthroline-2,9-diyl-1,2,4-triazine-5,5,6,6-tetrayl]tetrabenzenesulfonic acid was tested for its selectivity towards Am(III over Cm(III and Eu(III with a TODGA (N,N,Nʹ,Nʹ-tetraoctyldiglycolamide based solvent. Batch experiments were carried out using TS-BTPhen dissolved in aqueous nitric acid solution with tracers of 152Eu, 241Am and 244Cm. A significant increase of the separation factor for Cm over Am from SFCm/Am = 1.6 up to SFCm/Am = 3.3 was observed compared to the use of a TODGA-nitric acid system alone. Furthermore, stripping was possible at high nitric acid concentrations (0.6-0.7 mol/L resulting in a low sensitivity to acidity changes. The influence of the TS-BTPhen concentration was analyzed. A slope of -2 was expected taking into account literature stoichiometries of the lipophilic analogue CyMe4BTPhen. However, a slope of -1 was found. Batch stripping kinetics showed fast kinetics for the trivalent actinides. As an alternative organic ligand the methylated TODGA derivate Me-TODGA (2-methyl-N,N,Nʹ,Nʹ-tetraoctyldiglycolamide was tested in combination with the hydrophilic TS-BTPhen. The Am(III separation was achieved at even higher nitric acid concentrations compared to TODGA.

  5. T-S Fuzzy Model Based Control Strategy for the Networked Suspension Control System of Maglev Train

    OpenAIRE

    Guang He; Jie Li; Peng Cui; Yun Li

    2015-01-01

    The control problem for the networked suspension control system of maglev train with random induced time delay and packet dropouts is investigated. First, Takagi-Sugeno (T-S) fuzzy models are utilized to represent the discrete-time nonlinear networked suspension control system, and the parameters uncertainties of the nonlinear model have also been taken into account. The controllers take the form of parallel distributed compensation. Then, a sufficient condition for the stability of the netwo...

  6. Geomagnetic activity at Northern Hemisphere's mid-latitude ground stations: How much can be explained using TS05 model

    Science.gov (United States)

    Castillo, Yvelice; Pais, Maria Alexandra; Fernandes, João; Ribeiro, Paulo; Morozova, Anna L.; Pinheiro, Fernando J. G.

    2017-12-01

    For the 2007 to 2014 period, we use a statistical approach to evaluate the performance of Tsyganenko and Sitnov [2005] semi-empirical model (TS05) in estimating the magnetospheric transient signal observed at four Northern Hemisphere mid-latitude ground stations: Coimbra, Portugal; Panagyurishte, Bulgary; Novosibirsk, Russia and Boulder, USA. Using hourly mean data, we find that the TS05 performance is clearly better for the X (North-South) than for the Y (East-West) field components and for more geomagnetically active days as determined by local K-indices. In ∼ 50% (X) and ∼ 30% (Y) of the total number of geomagnetically active days, correlation values yield r ≥ 0.7. During more quiet conditions, only ∼ 30% (X) and ∼ 15% (Y) of the number of analyzed days yield r ≥ 0.7. We compute separate contributions from different magnetospheric currents to data time variability and to signal magnitude. During more active days, all tail, symmetric ring and partial ring currents contribute to the time variability of X while the partial ring and field aligned currents contribute most to the time variability of Y. The tail and symmetric ring currents are main contributors to the magnitude of X. In the best case estimations when r ≥ 0.7, remaining differences between observations and TS05 predictions could be explained by global induction in the Earth's upper layers and crustal magnetization. The closing of field aligned currents through the Earth's center in the TS05 model seems to be mainly affecting the Y magnetospheric field predictions.

  7. Coûts de la santé associés au tabagisme au Vietnam | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... particulièrement aux coûts économiques qu'entraîne la consommation élevée de tabac. Les constatations serviront à promouvoir la mise en oeuvre de politiques de lutte antitabac plus rigoureuses au Vietnam et la méthodologie, à orienter des initiatives similaires dans d'autres pays disposant de peu de données brutes.

  8. Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.

    Science.gov (United States)

    Shimohata, Atsushi; Ishihara, Keiichi; Hattori, Satoko; Miyamoto, Hiroyuki; Morishita, Hiromasa; Ornthanalai, Guy; Raveau, Matthieu; Ebrahim, Abdul Shukkur; Amano, Kenji; Yamada, Kazuyuki; Sago, Haruhiko; Akiba, Satoshi; Mataga, Nobuko; Murphy, Niall P; Miyakawa, Tsuyoshi; Yamakawa, Kazuhiro

    2017-07-01

    Ts1Cje mice have a segmental trisomy of chromosome 16 that is orthologous to human chromosome 21 and display Down syndrome-like cognitive impairments. Despite the occurrence of affective and emotional impairments in patients with Down syndrome, these parameters are poorly documented in Down syndrome mouse models, including Ts1Cje mice. Here, we conducted comprehensive behavioral analyses, including anxiety-, sociability-, and depression-related tasks, and biochemical analyses of monoamines and their metabolites in Ts1Cje mice. Ts1Cje mice showed enhanced locomotor activity in novel environments and increased social contact with unfamiliar partners when compared with wild-type littermates, but a significantly lower activity in familiar environments. Ts1Cje mice also exhibited some signs of decreased depression like-behavior. Furthermore, Ts1Cje mice showed monoamine abnormalities, including increased extracellular dopamine and serotonin, and enhanced catabolism in the striatum and ventral forebrain. This study constitutes the first report of deviated monoamine metabolism that may help explain the basis for abnormal behaviors, including the environmental stimuli-triggered hyperactivity, increased sociability and decreased depression-like behavior in Ts1Cje mice. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Advanced Turbine Technology Applications Project (ATTAP) and Hybrid Vehicle Turbine Engine Technology Support project (HVTE-TS): Final summary report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    This final technical report was prepared by Rolls-Royce Allison summarizing the multiyear activities of the Advanced Turbine Technology Applications Project (ATTAP) and the Hybrid Vehicle Turbine Engine Technology Support (HVTE-TS) project. The ATTAP program was initiated in October 1987 and continued through 1993 under sponsorship of the US Department of Energy (DOE), Energy Conservation and Renewable Energy, Office of Transportation Technologies, Propulsion Systems, Advanced Propulsion Division. ATTAP was intended to advance the technological readiness of the automotive ceramic gas turbine engine. The target application was the prime power unit coupled to conventional transmissions and powertrains. During the early 1990s, hybrid electric powered automotive propulsion systems became the focus of development and demonstration efforts by the US auto industry and the Department of energy. Thus in 1994, the original ATTAP technology focus was redirected to meet the needs of advanced gas turbine electric generator sets. As a result, the program was restructured to provide the required hybrid vehicle turbine engine technology support and the project renamed HVTE-TS. The overall objective of the combined ATTAP and HVTE-TS projects was to develop and demonstrate structural ceramic components that have the potential for competitive automotive engine life cycle cost and for operating 3,500 hr in an advanced high temperature turbine engine environment. This report describes materials characterization and ceramic component development, ceramic components, hot gasifier rig testing, test-bed engine testing, combustion development, insulation development, and regenerator system development. 130 figs., 12 tabs.

  10. Facile Synthesis of Yolk/Core-Shell Structured TS-1@Mesosilica Composites for Enhanced Hydroxylation of Phenol

    KAUST Repository

    Zou, Houbing

    2015-12-14

    © 2015 by the authors. In the current work, we developed a facile synthesis of yolk/core-shell structured TS-1@mesosilica composites and studied their catalytic performances in the hydroxylation of phenol with H2O2 as the oxidant. The core-shell TS-1@mesosilica composites were prepared via a uniform coating process, while the yolk-shell TS-1@mesosilica composite was prepared using a resorcinol-formaldehyde resin (RF) middle-layer as the sacrificial template. The obtained materials were characterized by X-ray diffraction (XRD), N2 sorption, Fourier transform infrared spectoscopy (FT-IR) UV-Visible spectroscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The characterization results showed that these samples possessed highly uniform yolk/core-shell structures, high surface area (560–700 m2 g−1) and hierarchical pore structures from oriented mesochannels to zeolite micropores. Importantly, owing to their unique structural properties, these composites exhibited enhanced activity, and also selectivity in the phenol hydroxylation reaction.

  11. T-S Fuzzy Model Based H-Infinity Control for 7-DoF Automobile Electrohydraulic Active Suspension System

    Directory of Open Access Journals (Sweden)

    Chenyu Zhou

    2017-01-01

    Full Text Available This paper presents a double loop controller for a 7-DoF automobile electrohydraulic active suspension via T-S fuzzy modelling technique. The outer loop controller employs a modified H-infinity feedback control based on a T-S fuzzy model to provide the actuation force needed to ensure better riding comfort and handling stability. The resulting optimizing problem is transformed into a linear matrix inequalities solution issue associated with stability analysis, suspension stroke limit, and force constraints. Integrating these via parallel distributed compensation method, the feedback gains are derived to render the suspension performance dependent on the perturbation size and improve the efficiency of active suspensions. Adaptive Robust Control (ARC is then adopted in the inner loop design to deal with uncertain nonlinearities and improve tracking accuracy. The validity of improvements attained from this controller is demonstrated by comparing with conventional Backstepping control and a passive suspension on a 7-DoF simulation example. It is shown that the T-S fuzzy model based controller can achieve favourable suspension performance and energy conservation under both mild and malevolent road inputs.

  12. FORMULASI PADAT RHIZOBAKTERIA INDIGENUS BACILLUS THURINGIENSIS TS2 DAN WAKTU PENYIMPANAN UNTUK MENGENDALIKAN PENYAKIT PUSTUL BAKTERI XANTHOMONAS AXONOPODIS PV. GLYCINES

    Directory of Open Access Journals (Sweden)

    Yulmira Yanti

    2017-05-01

    Full Text Available Solid formulations of indigenous rhizobacteria Bacillus thuringiensis TS2 and storage time to control bacterial pustule disease Xanthomonas axonopodis pv. glycines. Bacterial pustule disease caused by Xanthomonas axonopodis pv. Glycines is a major constraint in soybean cultivation. Indigenous rhizobacteria Bacillus thuringiensis TS2 from soybean rhizosphere acquired from previous research is the best isolate which can control soybean bacterial pustule disease and increase growth rate of soybean. To increased its stability and interaction with soybean plants, Bacillus thuringiensis TS2 was urged to test furthermore especially its formulation with based formula tapioca powder, peat and bulk. The most effective storage time also need to test. Result showed that all rhizobacterial formula had ability to decrease incidence of bacterial pustule disease compared to control. Moreover, all the three formula could increase plant growth, total of leaves, total of branch and yields. Flowering time was also advanced by 1-8 days compared to control. Decreasing of disease rate and increasing of plant growth rate variated between different formulations.

  13. Avaliação de diferentes biótipos periodontais e suas estruturas utilizando tomografia computadorizada tipo feixe cônico

    OpenAIRE

    Bazan, Diego Rodrigo Paulillo

    2013-01-01

    A preocupação em reconhecer o biótipo periodontal apresentado pelo paciente vem crescendo entre os cirurgiões-dentistas e não está vinculada somente aos profissionais que atuam na área de periodontia. Está também ligada aos profissionais da área de implantodontia e estética, pois sabe-se que o biótipo periodontal influencia no tratamento seja ele do tipo cirúrgico ou restaurador. São dois os tipos de biótipos reconhecidos, o tipo fino e o espesso. Estes respondem de maneira diferente frente a...

  14. A IDENTIFICAÇÃO DE TIPOS DE LIDERANÇA A PARTIR DE ARQUÉTIPOS

    Directory of Open Access Journals (Sweden)

    Adriana Nunes Lacerda e Prestupa

    2009-09-01

    junguianos analisados por Moore e Gillette (1993 foram relacionados com características de líderes dentro do contexto organizacional. Desta forma foi possível apresentar uma tipologia rica e aplicável, onde o individuo pode se identificar e também entender o processo e a maturação das características dos arquétipos estudados para melhor desempenho dentro das organizações.

  15. Análisis estadístico exploratorio de dos tipos de secado de quinua

    OpenAIRE

    Mena Reinoso, Angel Patricio

    2015-01-01

    El presente trabajo “Análisis Estadístico Exploratorio de dos Tipos de Secado de Quinua” permite realizar una validación estadística del tipo de secador que posea una alta eficiencia, rendimiento en el secado de este tipo de cereal (Chenopodium quinoa Willd). Para el efecto se empleó el secador de bandejas y un secador solar tipo invernadero, el experimento se llevó a cabo con tres tipos de muestras, una con cascara y las otras escarificadas. La quinua fue sometida a un secado ...

  16. Síndrome de Waardenburg tipo I: relato de caso

    Directory of Open Access Journals (Sweden)

    Patricia Capua Vieira da Silva

    2011-06-01

    Full Text Available A síndrome de Waardenburg tipo I é uma desordem auditivo-pigmentária que inclui, entre outros, perda auditiva neurossensorial congênita não progressiva, telecanto, distúrbios pigmentares de íris, cabelo e pele. Indivíduos afetados podem ter maior risco de: defeitos no tubo neural, fendas labial e palatina, anormalidades nos membros e doença de Hirschsprung. O diagnóstico é clínico, sendo necessários dois critérios maiores ou um maior e dois menores. PAX3 é o único gene conhecido associado à síndrome, sendo, entretanto, mais usado no aconselhamento genético. Quanto ao diagnóstico diferencial, podemos citar: outras causas de perda auditiva neurossensorial congênita não progressiva, outros tipo de síndrome de Waardenburg, piebaldismo, albinismo, vitiligo e síndrome de Teitz. Neste trabalho, apresenta-se um paciente masculino de 11 anos com diagnóstico de síndrome de Waardenburg tipo I. Ressalta-se a importância do oftalmologista no auxílio do diagnóstico deste raro quadro sistêmico, uma vez que inclui algumas alterações oftalmológicas. O diagnóstico precoce da síndrome permite estimulação adequada para a perda auditiva, assim como medidas preventivas em caso de gestantes afetadas no aconselhamento genético.

  17. The Functional and Regulatory Mechanisms of the Thellungiella salsuginea Ascorbate Peroxidase 6 (TsAPX6 in Response to Salinity and Water Deficit Stresses.

    Directory of Open Access Journals (Sweden)

    Zeqin Li

    Full Text Available Soil salinization is a resource and ecological problem in the world. Thellungiella salsuginea is becoming a new model plant because it resembles its relative species, Arabidopsis thaliana, in small genome and short life cycle. It is highly tolerant to salinity and drought stresses. Ascorbate peroxidase (APX is an enzyme that clears H2O2 in plants. The function and molecular and regulation mechanisms of APX in T. salsuginea have rarely been reported. In this study, an APX gene, TsApx6, was cloned from T. salsuginea and its responses to abiotic stresses in transgenic Arabidopsis were studied. Under high salinity treatment, the expression of TsApx6 was significantly induced. Under drought treatment, overexpression of TsApx6 increased the survival rate and reduced leaf water loss rate in Arabidopsis. Compared to the wild type plants, high salinity treatment reduced the concentrations of MDA, H2O2 and proline but elevated the activities of APX, GPX, CAT and SOD in the TsApx6-overexpressing plants. Meanwhile, germination rate, cotyledon greening, and root length were improved in the transgenic plants compared to the wild type plants under salt and water deficit conditions. Based on these findings, TsApx6 has an important function in the resistance of plants to certain abiotic stresses. The TsApx6 promoter sequence was obtained using Genome Walking technology. Bioinformatics analysis indicated that it contains some cis-acting elements related to stress response. The treatments of salt, dehydration, and ABA induced the expression of Gus gene under the regulation of the TsApx6 promoter. Mutation analysis showed that the MBS motif present in the TsApx6 promoter might be a key negative regulatory element which has an important effect on the growth and developmental process of plants.

  18. INVESTIGATIONS ON THE MYCOFLORA AND PROCESSING EFFECTS ON THE NUTRITIONAL QUALITY OF PEANUT (ARACHIS HYPOGEA L. VAR. TS 32-1)

    OpenAIRE

    Euloge S. Adjou; Edwige Dahouenon-Ahoussi; Mohamed M. Soumanou

    2012-01-01

    The microbiological and nutritional characterization of peanut (Arachis hypogea L var. TS 32-1) was investigated. Bacteria and fungi were isolated from this product. The fungal isolates were Aspergillus niger, Aspergillus flavus, Aspergillus parasiticus Speare, Aspergillus ochraceus Wilhelm and Fusarium poae. The respective mean moisture content and total acidity in samples were 8.19 ± 0.01% and 1.2 ± 0.02%. Nutritional analysis showed that peanut (Arachis hypogea L var. TS 32-1) has interest...

  19. Propiedades y aplicaciones de piezocomposites tipo címbalo

    Directory of Open Access Journals (Sweden)

    Ochoa, P.

    2001-08-01

    Full Text Available The metal-ceramic composite actuators, moonies and cymbals consist in capped piezoceramic disks with metallic endcaps having cavities inside. These cavities favour the amplification of direct and reverse piezoelectric effects. These actuators fill the gap between high displacement low generative force bimorph actuators and low displacement high generative force multilayer ceramic actuators. The moonie actuator can give displacements greater than 100 mm, maximum generative force of 3N to several N´s, response time of 20 to 100 ms, and low fatigue test response for more than 107 cycles. Cymbals actuators shows twice as big as displacement than moonie for the studied size, much higher generative force and the possibility to avoid the temperature dependence of the displacement for selected materials. Properties of cymbal actuators can be tailored trough the selection of materials. Also, cymbal actuators can be tuned to adopt different resonance frequencies.

    Los composites metal-cerámica tipo luna y címbalo consisten en discos piezoeléctricos encapsulados con cápsulas metálicas que poseen una cavidad. Esta cavidad favorece la amplificación de los efectos piezoeléctricos directo e inverso. Estos actuadores llenan el escalón entre actuadores multicapa, con desplazamientos pequeños y fuerzas generativas elevadas, y actuadores bimorfos, con desplazamientos grandes y fuerzas generativas pequeñas. El actuador tipo luna alcanza desplazamientos de más de 100mm, fuerzas generativas máximas de hasta varios N´s, tiempos de respuesta desde 20 hasta 100ms, y baja respuesta en ensayos de fatiga a más de 107 ciclos. Los actuadores tipo címbalo muestran desplazamientos dos veces mayores que los obtenidos con actuadores tipo luna para el mismo tamaño, fuerzas generativas mucho mayores y la posibilidad de eliminar la dependencia del desplazamiento con la temperatura mediante selección de los materiales. Además poseen unas caracter

  20. SÍNDROME MAROTEAUX-LAMY (MUCOPOLISACARIDOSIS TIPO VI)

    OpenAIRE

    Iván Hernández Ramírez; Ramiro José Benavides; Iván Osbaldo Yamá Noguera; Jennifer Martínez España; Carlos Hernando Rosero Erazo

    2012-01-01

    Se describe el caso clínico de un paciente masculino de 17 años de edad, que presentó: talla baja, malformaciones óseo-esqueléticas, rasgos faciales toscos, hernia inguinal, hernia umbilical, disostosis múltiples, hepatoesplenomegalia, y dificultad respiratoria; antecedentes quirúrgicos: herniorrafia inguinal derecha y herniorrafia umbilical, alteraciones correspondientes a Mucopolisacaridosis (MPS) tipo VI, diagnóstico confirmado por estudio inmunohistoquímico enzimático, que reportó deficie...

  1. Fundamentos del Tipo de Cambio Real en Chile

    OpenAIRE

    Rodrigo Cerda; Alvaro Donoso; Aldo Lema

    2003-01-01

    Un modelo basado en la relación gasto-producto (efecto Salter-Swan) y los términos de intercambio, habría predicho un incremento más pronunciado del tipo de cambio real (TCR) en Chile durante la segunda mitad de los '80, una caída menos acentuada entre 1990 y 1997, y un aumento más fuerte a partir de 1998 cuando irrumpió la crisis financiera internacional. Este trabajo incorpora en forma exhaustiva otros factores en la determinación de largo plazo del TCR, tanto de oferta como de demanda. Usa...

  2. Sarcopenia en pacientes con diabetes mellitus tipo 2.

    OpenAIRE

    Vergara Ruiz, José Carlos

    2015-01-01

    El riesgo de discapacidad es mayor en pacientes con diabetes mellitus tipo 2 (DM2). Buena parte del mismo se debe al envejecimiento del músculo esquelético o sarcopenia. El déficit de fuerza muscular asociado a la edad tiene mayor asociación con la pérdida de funcionalidad que el mismo proceso cuando afecta a la masa muscular esquelética, y no ocurren de forma paralela ni proporcional. Recientemente se ha propuesto el término dinapenia para referirse a ésta pérdida de fuerza muscular, con ind...

  3. Tipos de Tiempo en el periodo de Semana Santa Vallisoletana.

    OpenAIRE

    Miranda Martín, Javier

    2017-01-01

    El propósito del proyecto es el análisis y la caracterización de ciertos tipos de tiempo a partir de los datos observados de la Base de Datos Climatológica del Observatorio de Valladolid. Los datos analizados corresponden a los ocho días de Semana Santa de un periodo de 37 años que comprenden entre los años 1981 y 2017. Grado en Geografía y Ordenación del Territorio

  4. Estresse em mulheres com Diabetes mellitus tipo 2

    OpenAIRE

    Lessmann, Juliana Cristina; Silva, Denise Maria Guerreiro Vieira da; Nassar, Silvia Modesto

    2011-01-01

    OBJETIVO: O objetivo do estudo foi investigar a relação entre estresse e Diabetes Mellitus Tipo 2 em mulheres. MÉTODO: Estudo transversal prospectivo, desenvolvido com 147 mulheres, utilizando a Escala de Estresse Percebido (PSS). RESULTADOS: Houve associação entre as variáveis testadas, sendo possível inferir que as mulheres com estresse elevado são as que vivenciaram sofrimento e apresentam controle glicêmico alterado, ou seja, com valores superiores a 180 mg/dL. A maioria relatou sofriment...

  5. Diabetes tipo 2 y obesidad leve: tratamiento quirúrgico

    OpenAIRE

    Lanzaren S,Enrique

    2013-01-01

    Introducción: En la actualidad la diabetes mellitus tipo 2 (DM2) y la obesidad representan un serio problema de salud, comportándose como enfermedades epidémicas. Existe un gran interés en explorar distintas opciones de tratamiento de la DM2 en pacientes que no tienen obesidad mórbida. Objetivo: Reportar los parámetros de control glicémico en pacientes con DM2 y obesidad leve sometidos a bypass gástrico (BPG) a 3 años de seguimiento. Metodología: Estudio clínico prospectivo que incluye pacien...

  6. OTROS TIPOS ESPECÍFICOS DE DIABETES MELLITUS

    OpenAIRE

    DRA. M. Gabriela Sanzana G.; BQ. Pilar Durruty A.

    2016-01-01

    La clasificación etiológica de la American Diabetes Association (ADA) de la diabetes incluye el grupo de “Otros tipos específicos de diabetes”, constituido por 8 subgrupos, que en su totalidad son de baja frecuencia. Del largo listado, los Maturity Onset Diabetes in the Young (MODY) y las inducidas por fármacos, las que vemos en la práctica clínica; la diabetes lipoatrófica, las asociadas a hemocromatosis y a síndrome de Down, entre otras, se presentan ocasionalmente; y de las “formas infrecu...

  7. Resultados tipo Bernstein em M2 x R

    OpenAIRE

    Jose Wilker de Lima Silva

    2007-01-01

    Apresentaremos uma fÃrmula para o Laplaciano da funÃÃo Θ = onde f : Sigma ^ {n} → M^{n } à R à uma imersÃo com codimensÃo um, Sigma ^{n}à uma hiperfÃcie two-sided, T à um campo conforme em Sigma ^{n} à R e n à um campo unitÃrio normal a Sigma ^{n} em M^{n} à R. Usaremos tal fÃrmula para obtermos alguns resultados tipo Bernstein em M2 à R.

  8. Les coûts subjectifs de l’enquête ethnographique

    Directory of Open Access Journals (Sweden)

    Bénédicte Havard Duclos

    2007-06-01

    Full Text Available L’enquête ethnographique implique toujours un engagement personnel et de longue durée du chercheur, et donc une socialisation minimale au milieu enquêté. Dans une enquête dans des associations, partis ou mouvements militants, dont un des enjeux est de produire de l’adhésion et de l’« enrôlement », la sur-socialisation au milieu enquêté est d’autant plus probable que l’affinité du chercheur avec la cause défendue est préalable au démarrage de l’enquête. À travers le récit du déroulement de l’enquête et des états psycho-moraux traversés au cours de celle-ci, sont ici donnés à voir tant les conditions rendant possibles l’adhésion et la loyauté militantes que les coûts subjectifs et éthiques liés à la rupture avec le terrain, constitutive de l’acte d’écriture.The subjective costs of the ethnographic work. Investigate as activist in the association Droit Au Logement (DAL at the end of 1990sField research always implies the personal and long-term commitment of the researcher, and thus a minimal socialization in the world investigated. In a research in activist movement, which goal is to produce commitment, these socialization can be very strong, especially when the researcher was still an activist in the starting up of the field work. Through the telling the story of progress of the research and psycho-moral states crossed during this one, are here given to see the conditions making possible the activist loyalty and the subjective and ethical costs connected to the break with the field, which is a necessity of the act of writing.Los costos subjetivos de la encuesta etnográfica. Investigar siendo militante en la asociación Droit Au Logement (DAL a fines de los años 1990.La encuesta etnográfica implica un compromiso personal de duración larga del investigador; lo que significa una socialización mínima del medio estudiado. Investigar en los medios asociativos, de partidos o de movimientos

  9. Performance of the transition radiation detector flown on the NMSU/WIZARD TS93 balloon-borne instrument

    Energy Technology Data Exchange (ETDEWEB)

    Aversa, F.; Barbiellini, G.; Boezio, M. [Trieste Univ. (Italy). Dip. di Fisica]|[INFN, Trieste (Italy); Basini, G.; Brancaccio, F.M. [INFN, Laboratori nazionali di Frascati, Frascati, Rome (Italy); Bellotti, R. [Bari Univ. (Italy). Dip. di Fisica]|[INFN, Bari (Italy); Bidoli, V. [Rome Univ. `Tor Vergata` (Italy). Dip. di Fisica]|[INFN, Sezione Univ. `Tor Vergata` Rome (Italy); Bocciolini, M. [Florence Univ. (Italy). Dip. di Fisica]|[INFN, Florence (Italy); Bronzini, F. [Rome Univ. `La Sapienza` (Italy). Dip. di Fisica]|[INFN, Sezione Univ. `La Sapienza` Rome (Italy)

    1995-09-01

    It is built and tested a transition radiation detector (TRD) to discriminate positrons from protons in the balloon flight TS 93 experiment. It is presented the TRD performance using flight data obtaining a proton-positron rejection factor of the order of 10{sup -3}. During the 24 hour flight, the data in the momentum range 4-50 GeV/c are collected. Using the TRD together with the Silicon calorimeter, it is achieved an overall rejection factor of about 10{sup -5} of positron against the proton background over the entire momentum range.

  10. poolHiTS: A Shifted Transversal Design based pooling strategy for high-throughput drug screening

    Directory of Open Access Journals (Sweden)

    Woolf Peter J

    2008-05-01

    Full Text Available Abstract Background A key goal of drug discovery is to increase the throughput of small molecule screens without sacrificing screening accuracy. High-throughput screening (HTS in drug discovery involves testing a large number of compounds in a biological assay to identify active compounds. Normally, molecules from a large compound library are tested individually to identify the activity of each molecule. Usually a small number of compounds are found to be active, however the presence of false positive and negative testing errors suggests that this one-drug one-assay screening strategy can be significantly improved. Pooling designs are testing schemes that test mixtures of compounds in each assay, thereby generating a screen of the whole compound library in fewer tests. By repeatedly testing compounds in different combinations, pooling designs also allow for error-correction. These pooled designs, for specific experiment parameters, can be simply and efficiently created using the Shifted Transversal Design (STD pooling algorithm. However, drug screening contains a number of key constraints that require specific modifications if this pooling approach is to be useful for practical screen designs. Results In this paper, we introduce a pooling strategy called poolHiTS (Pooled High-Throughput Screening which is based on the STD algorithm. In poolHiTS, we implement a limit on the number of compounds that can be mixed in a single assay. In addition, we show that the STD-based pooling strategy is limited in the error-correction that it can achieve. Due to the mixing constraint, we show that it is more efficient to split a large library into smaller blocks of compounds, which are then tested using an optimized strategy repeated for each block. We package the optimal block selection algorithm into poolHiTS. The MATLAB codes for the poolHiTS algorithm and the corresponding decoding strategy are also provided. Conclusion We have produced a practical version

  11. Ectopic Anterior Mediastinal Pathology in the Chest: Radiologic-pathologic Correlation of Unexpected Encounters with the "Terrible Ts".

    Science.gov (United States)

    Rashidfarokhi, Mahsan; Gupta, Jessica; Leytin, Anatoly; Epelbaum, Oleg

    2016-01-01

    The complex embryology of the anterior mediastinum makes it home to an array of primary neoplasms tied to the presence of the thyroid and thymus glands in that compartment. While the occurrence of ectopic thyroid deposits in the extramediastinal thorax has not been convincingly established, the other three "Ts" of the classic "4T" mnemonic for the differential diagnosis of an anterior mediastinal mass have occurred in the lung parenchyma, pleural space, and endobronchially as primary tumors. Finding any of the three lesions - thymoma, teratoma, or B-cell lymphoma - in the chest outside the mediastinum is very unusual, but that possibility exists. Herein, we illustrate examples of this rare phenomenon.

  12. PRODUCT NEEM AZAL T/S - BROAD-SPECTRUM PHYPOPESTICIDE FOR CONTROL OF PESTS ON VEGETABLE CROPS

    Directory of Open Access Journals (Sweden)

    Vinelina Yankova

    2016-09-01

    Full Text Available Experiments for determination of the effectiveness of product Neem Azal T/S (a. i. azadirachtin were conducted at a concentration of 0,3% against some major pests in vegetable crops grown in greenhouses at the Maritsa Vegetable Crops research Institute, Plovdiv during the period 2010-2016. It was established very good insecticidal and acaricidal action of phytopesticide against: cotton aphid (Aphis gossypii Glov.; green peach aphid (Myzus persicae Sulz.; western flower trips (Frankliniella occidentalis Perg.; cotton bollworm (Helicoverpa armigera Hubn.; tomato borer (Tuta absoluta Meyrick and two-spotted spider mite (Tetranichus urticae Koch.. This product is a successful alternative to using chemical insecticides and acaricides.

  13. Diabetes mellitus tipo 2 y resistencia a la insulina

    Directory of Open Access Journals (Sweden)

    Enrique Cipriani-Thorne

    2010-07-01

    Full Text Available Se analizó la literatura de los últimos 15 años para poder objetivar los temas que son materia de esta comunicación. En primer lugar se analiza en qué consiste el llamado Síndrome Metabólico, sus características; a continuación se resume la historia natural de la Diabetes Mellitus tipo II y su patogenia. Se revisa la importancia de la resistencia a la insulina en el músculo estriado principal órgano de combustión de la glucosa y el factor mitocondrial de la resistencia a la insulina. Se analiza además la importancia de resistencia a la insulina con respecto al metabolismo del hígado y en particular a las alteraciones del metabolismo del colesterol y de los triglicéridos. Se hace un comentario extenso de cómo así la Diabetes Mellitus Tipo II es considerada en la actualidad como una enfermedad de origen inflamatorio y por último se discuten las consecuencias de la hiperinsulinemia, dado que el exceso de insulina es producido por el bloqueo en la línea metabólica de su acción más no en su línea de producir proliferación tisular.(Rev Med Hered 2010;21:160-170.

  14. Ocorrência de Staphylococcus aureus em queijo tipo "frescal"

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    Almeida Filho Edvaldo Sampaio de

    2000-01-01

    Full Text Available OBJETIVO: Verificar a ocorrência de Staphylococcus aureus em uma amostra de queijo tipo Minas "frescal" comercializado na cidade de Poços de Caldas, MG, de modo a obter subsídios que permitam avaliar o risco potencial que este produto pode representar para a saúde da população consumidora. MÉTODOS: Foi investigada a presença e o número de cepas de Staphylococcus aureus em 80 amostras de queijo tipo Minas "frescal" produzido artesanalmente e comercializado na cidade de Poços de Caldas, MG, Brasil. RESULTADOS: Os resultados obtidos evidenciaram a presença de S. aureus em 40 (50,0% amostras, cujas contagens revelaram valores médios em torno de 10(5/g. CONCLUSÕES: Tais achados parecem ser extremamente preocupantes, pois além de se situarem acima do limite máximo de 10³/g estabelecido pelo Ministério da Saúde, estes valores mostraram-se muito próximos dos requeridos para a produção de enterotoxinas em quantidades suficientes para a ocorrência de surtos de intoxicação alimentar estafilocócica.

  15. Ocorrência de Staphylococcus aureus em queijo tipo "frescal"

    Directory of Open Access Journals (Sweden)

    Edvaldo Sampaio de Almeida Filho

    2000-12-01

    Full Text Available OBJETIVO: Verificar a ocorrência de Staphylococcus aureus em uma amostra de queijo tipo Minas "frescal" comercializado na cidade de Poços de Caldas, MG, de modo a obter subsídios que permitam avaliar o risco potencial que este produto pode representar para a saúde da população consumidora. MÉTODOS: Foi investigada a presença e o número de cepas de Staphylococcus aureus em 80 amostras de queijo tipo Minas "frescal" produzido artesanalmente e comercializado na cidade de Poços de Caldas, MG, Brasil. RESULTADOS: Os resultados obtidos evidenciaram a presença de S. aureus em 40 (50,0% amostras, cujas contagens revelaram valores médios em torno de 10(5/g. CONCLUSÕES: Tais achados parecem ser extremamente preocupantes, pois além de se situarem acima do limite máximo de 10³/g estabelecido pelo Ministério da Saúde, estes valores mostraram-se muito próximos dos requeridos para a produção de enterotoxinas em quantidades suficientes para a ocorrência de surtos de intoxicação alimentar estafilocócica.

  16. Resistencia de las conexiones tipo canal a elevadas temperaturas

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    Yisel Larrúa-Pardo

    2015-01-01

    Full Text Available En el trabajo se realiza el aná lisis térmico del ensayo push-ou t de conexiones tipo canal en estructuras compuestas acero – co ncreto a elevadas temperaturas a partir d e resultados numéricos generado s por el programa SuperTempcalc. El estudio se realiza para dos alternativas: vigas sin revestimie nto contra incendio y vigas r evestidas. Se proponen las temperaturas a considerar en el conc reto para determinar los factores de reduc ción de su resistencia y se val ora el impacto de estos resultados en la determinación de la re sistencia de la conexión. Finalmente, se propone un método simplificado para de terminar la resistencia de la conexión, que considera temperatu ras en el concreto definidas a través del análisis térmico y es coherente con las expresiones de cálculo de la resistencia de las conexi ones tipo canal a temperatura ambiente y con la formulación para conexiones tip o perno a elevada s temperaturas vigente en la literatura intern acional.

  17. Disturbance observer-based L1 robust tracking control for hypersonic vehicles with T-S disturbance modeling

    Directory of Open Access Journals (Sweden)

    Yang Yi

    2016-11-01

    Full Text Available This article concerns a disturbance observer-based L1 robust anti-disturbance tracking algorithm for the longitudinal models of hypersonic flight vehicles with different kinds of unknown disturbances. On one hand, by applying T-S fuzzy models to represent those modeled disturbances, a disturbance observer relying on T-S disturbance models can be constructed to track the dynamics of exogenous disturbances. On the other hand, L1 index is introduced to analyze the attenuation performance of disturbance for those unmodeled disturbances. By utilizing the existing convex optimization algorithm, a disturbance observer-based proportional-integral-controlled input is proposed such that the stability of hypersonic flight vehicles can be ensured and the tracking error for velocity and altitude in hypersonic flight vehicle models can converge to equilibrium point. Furthermore, the satisfactory disturbance rejection and attenuation with L1 index can be obtained simultaneously. Simulation results on hypersonic flight vehicle models can reflect the feasibility and effectiveness of the proposed control algorithm.

  18. L’INTÉGRATION MONÉTAIRE DE LA ROUMANIE ENTRE COÛTS ET BÉNÉFICES

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    Lucian Belascu

    2008-05-01

    Full Text Available Il n’y a pas dans notre pays de stratégie qui concerne bien techniquement l’adoption del’euro. Il s’imposerait d’essayer, quoiqu’il soit très téméraire, d’identifier le moment opportun pourl’introduction de l’euro. Ce n’est pas facile mais il faut s’y mettre puisqu’il s’agit de faire suivre l’évolution etl’identification des tendances d’intégration de la Roumanie dans la zone euro, de faire également attention auxmodèles d’intégration monétaires développés en Europe et bien entendu de mettre en place des scénariosalternatives pour la Roumanie. Et tout cela tout en évaluant de près les coûts et les bénéfices de l’adoption del’euro car l’intégration monétaire de la Roumanie est bien importante et le fait d’envisager aussi où l’on estavec les coûts pourrait nous faire éviter certains pièges. Dans notre communication, nous essayons justement demettre en discussion notamment ces derniers aspects.

  19. TS-1 supported highly dispersed sub-5 nm gold nanoparticles toward direct propylene epoxidation using H2 and O2

    Science.gov (United States)

    Li, Naixu; Chen, Yong; Shen, Quanhao; Yang, Bin; Liu, Ming; Wei, Lingfei; Tian, Wei; Zhou, Jiancheng

    2018-05-01

    We report a simple and efficient method for the preparation of highly dispersed Au nanoparticles (< 5 nm) on TS-1 substrate. The synthesis relies on the use of NaBH4 as a reductant for rapid Au atom generation, as well as PVA as a capping agent confining the particle size and dispersion. The samples were characterized by N2 physisorption, inductively coupled plasma mass spectrometry, power X-ray diffraction, scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, CO pulse chemisorption and thermogravimetric analysis. The size of Au particles can be controlled in the range of 3-5 nm. The supported catalyst shows both good activity and selectivity for propylene oxide (PO) generation from direct propylene epoxidation. An optimal performance with PO formation rate of 102.94 gPO h-1 kg-1cat and selectivity of 84.83% is achieved over 2.0 wt% Au/TS-1 catalyst, which is prepared by controlling PVA/Au3+ mass ratio of 1.5/1 and NaBH4/Au3+ mole ratio of 5/1. After 50 h test at 200 °C, no significant decrement of both catalytic activity and PO selectivity can be observed, indicating the excellent thermally stability of the catalyst. Furthermore, a possible reaction mechanism is described on basis of the previous researches and our experimental results.

  20. Altered Synaptic Marker Abundance in the Hippocampal Stratum Oriens of Ts65Dn Mice is Associated with Exuberant Expression of Versican

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    Matthew D Howell

    2012-01-01

    Full Text Available DS (Down syndrome, resulting from trisomy of chromosome 21, is the most common cause of genetic mental retardation; however, the molecular mechanisms underlying the cognitive deficits are poorly understood. Growing data indicate that changes in abundance or type of CSPGs (chondroitin sulfate proteoglycans in the ECM (extracellular matrix can influence synaptic structure and plasticity. The purpose of this study was to identify changes in synaptic structure in the hippocampus in a model of DS, the Ts65Dn mouse, and to determine the relationship to proteoglycan abundance and/or cleavage and cognitive disability. We measured synaptic proteins by ELISA and changes in lectican expression and processing in the hippocampus of young and old Ts65Dn mice and LMCs (littermate controls. In young (5 months old Ts65Dn hippocampal extracts, we found a significant increase in the postsynaptic protein PSD-95 (postsynaptic density 95 compared with LMCs. In aged (20 months old Ts65Dn hippocampus, this increase was localized to hippocampal stratum oriens extracts compared with LMCs. Aged Ts65Dn mice exhibited impaired hippocampal-dependent spatial learning and memory in the RAWM (radial-arm water maze and a marked increase in levels of the lectican versican V2 in stratum oriens that correlated with the number of errors made in the final RAWM block. Ts65Dn stratum oriens PNNs (perineuronal nets, an extension of the ECM enveloping mostly inhibitory interneurons, were dispersed over a larger area compared with LMC mice. Taken together, these data suggest a possible association with alterations in the ECM and inhibitory neurotransmission in the Ts65Dn hippocampus which could contribute to cognitive deficits.

  1. Feeling powerless: a feeling expressed by caregivers of sexual violence victims Sentirse impotente: un sentimiento expresado por cuidadores de víctimas de violencia sexual Sentir-se impotente: um sentimento expresso por cuidadores de vítimas de violência sexual

    Directory of Open Access Journals (Sweden)

    Maria Eduarda Cavadinha Correa

    2009-06-01

    actuar adecuadamente, y que las instituciones promuevan capacitación permanente.Trata-se de pesquisa fenomenológica que teve como objetivo desvelar o significado da vivência no cuidar de vítimas de violência sexual. Foi realizada de dezembro de 2006 a março de 2007, com 12 profissionais de saúde. A coleta dos discursos ocorreu mediante entrevista semiestruturada gravada, e a análise se deu pela descrição, redução e compreensão do fenômeno. Dessa, emergiu o tema: sentir-se impotente, um sentimento expresso por corporeidades cuidadoras de vítimas de violência sexual. O sentimento de impotência é alimentado continuamente no cotidiano dos profissionais, diante da impossibilidade de resolver a situação da violência, de problemas que emergem da subjetividade do outro, bem como de questões sociais, porque não foram preparados para isso. Assim, é imprescindível que o tema seja abordado tanto na graduação como na pós-graduação dos cursos da área da saúde e humanas, a fim de que esses profissionais possam atuar adequadamente, e que as instituições promovam capacitação permanente.

  2. Verbal contents expressed by mothers of preterm infants with clinical emotional symptoms Contenido verbal expresado por las madres de bebés prematuros con síntomas emocionales clínicos Conteúdos verbais expressos por mães de bebês prematuros com sintomas emocionais clínicos

    Directory of Open Access Journals (Sweden)

    Luciana Leonetti Correia

    2008-02-01

    ás expresiones referentes a la primera categoría que el Grupo MSIE. La identificación de los sentimientos y reacciones de las madres de neonatos prematuros y de los síntomas emocionales clínicos deben ser incluidas para realizar una adecuada intervención en el desarrollo individualizado del bebé en una UTIN.O objetivo do estudo foi caracterizar os conteúdos verbais maternos expressos durante intervenção de apoio psicológico. A amostra foi composta por 20 mães de neonatos pré-termo com muito baixo peso, internados em UTI Neonatal, distribuída em 10 mães com indicadores clínicos emocionais (MCIE e 10 mães sem estes indicadores (MSIE, avaliadas pelos Inventários de Depressão de Beck e de Ansiedade Traço-Estado. As verbalizações maternas expressas no grupo de apoio foram gravadas, transcritas e categorizadas. Os resultados mostraram que as categorias sobre sentimentos ou reações maternas com conotação negativa ou conotação positiva e comunicação com a equipe de saúde foram as mais freqüentes. Na comparação entre os grupos, o Grupo MCIE verbalizou mais expressões referentes à primeira categoria quando comparado ao Grupo MSIE. A identificação dos sentimentos e reações de mães de neonatos pré-termo e dos sintomas emocionais clínicos deve ser incluída para adequada intervenção em cuidado desenvolvimental em UTIN.

  3. A ultra-sonografia do pâncreas é eficaz em diagnosticar o diabete melito tipo 1 e tipo 2?

    Directory of Open Access Journals (Sweden)

    Pimenta Walkyria de Paula

    2002-01-01

    Full Text Available Este trabalho foi realizado para verificar se a ultra-sonografia do pâncreas oferece dados auxiliares na classificação de diabéticos adultos dos tipos 1 e 2. O tamanho e a ecogenicidade do pâncreas foram determinados pela ultra-sonografia em 81 diabéticos, sendo 20 do tipo 1 e 61 do tipo 2 (53 obesos e oito não-obesos. Os pacientes tipo 2 obesos diferiram dos demais por apresentarem área total e diâmetro ântero-posterior do corpo do pâncreas significativamente maiores. Quanto à ecogenicidade pancreática, esta estava aumentada com maior freqüência nos diabéticos tipo 2 obesos que nos diabéticos tipo 1. Consideramos, assim, que a ultra-sonografia do pâncreas constitui metodologia auxiliar na classificação de diabéticos entre os tipo 1 e 2, sendo menos eficaz quando os últimos não são obesos.

  4. A ultra-sonografia do pâncreas é eficaz em diagnosticar o diabete melito tipo 1 e tipo 2?

    Directory of Open Access Journals (Sweden)

    Walkyria de Paula Pimenta

    2002-07-01

    Full Text Available Este trabalho foi realizado para verificar se a ultra-sonografia do pâncreas oferece dados auxiliares na classificação de diabéticos adultos dos tipos 1 e 2. O tamanho e a ecogenicidade do pâncreas foram determinados pela ultra-sonografia em 81 diabéticos, sendo 20 do tipo 1 e 61 do tipo 2 (53 obesos e oito não-obesos. Os pacientes tipo 2 obesos diferiram dos demais por apresentarem área total e diâmetro ântero-posterior do corpo do pâncreas significativamente maiores. Quanto à ecogenicidade pancreática, esta estava aumentada com maior freqüência nos diabéticos tipo 2 obesos que nos diabéticos tipo 1. Consideramos, assim, que a ultra-sonografia do pâncreas constitui metodologia auxiliar na classificação de diabéticos entre os tipo 1 e 2, sendo menos eficaz quando os últimos não são obesos.

  5. Una propuesta de tipo investigativo - interventivo para construir resiliencia

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    Sandra Liliana Aya Angarita

    2012-01-01

    Full Text Available Este artículo continúa con las reflexiones planteadas en la tesis magistral “Procesos de construcciónnarrativa que organizan experiencias resilientes enfamilias en situación de desplazamiento, en la interaccióninstitución familia” (articulada a la Maestríade Psicología Clínica y de Familia de la Universidad Santo Tomás, en las que se pretende comprender losprocesos de construcción narrativa y el interventivo busca movilizar dichos procesos hacia la emergenciade experiencias resilientes. El texto muestra algunos resultados de la intención interventiva, definiendola resiliencia desde diversas perspectivas, para luego conectar dichos significados con los procesos de construcción narrativa. Finalmente se proponenideas acerca de cómo en un escenario conversacional de tipo reflexivo es posible movilizar procesos haciala construcción de experiencias resilientes.

  6. Cirurgia metabólica: cura para diabete tipo 2

    OpenAIRE

    Zeve, Jorge Luiz de Mattos; Tomaz, Carlos Alberto Bezerra

    2011-01-01

    INTRODUÇÃO: O diabete melito tipo 2 é doença metabólica caracterizada por hiperglicemia crônica que está associada com dano e insuficiência de vários órgãos. A evolução da doença é a causa mais comum de cegueira, amputações e insuficiência renal em adultos no ocidente, além de aumentar a incidência de infarto agudo do miocárdio e acidente vascular cerebral, com maior mortalidade dos pacientes. A associação dele com obesidade é relevante. Os pacientes obesos diabéticos quando submetidos ao tra...

  7. SÍNDROME MAROTEAUX-LAMY (MUCOPOLISACARIDOSIS TIPO VI

    Directory of Open Access Journals (Sweden)

    Iván Hernández Ramírez

    2012-09-01

    Full Text Available Se describe el caso clínico de un paciente masculino de 17 años de edad, que presentó: talla baja, malformaciones óseo-esqueléticas, rasgos faciales toscos, hernia inguinal, hernia umbilical, disostosis múltiples, hepatoesplenomegalia, y dificultad respiratoria; antecedentes quirúrgicos: herniorrafia inguinal derecha y herniorrafia umbilical, alteraciones correspondientes a Mucopolisacaridosis (MPS tipo VI, diagnóstico confirmado por estudio inmunohistoquímico enzimático, que reportó deficiencia de Arilsulfatasa. Se procedió al manejo farmacológico con Galsulfasa para controlar el progreso de los signos y síntomas característicos, así como las complicaciones producidas por la enfermedad.

  8. formales o categorías tipo interfase?

    Directory of Open Access Journals (Sweden)

    Julio Alfonso Piña López

    2011-01-01

    Full Text Available Se analiza la relación entre los fenómenos básicos y los fenómenos del desarrollo y la personalidad, en términos de si los primeros deberían concebirse como condición de existencia necesaria y suficiente de los segundos, y, a su vez, si los unos y los otros lo son de los últimos. Se concluye que dependiendo de cómo se plantee dicha relación, es que eventualmente tendrá sentido la construcción de teorías formales sobre el desarrollo y la personalidad, o bien caracterizar ambos fenómenos como categorías tipo interfase con fines de predicción.

  9. Tipos de socialización y desesperanza aprendida

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    Sandro Macassi

    1988-12-01

    Full Text Available Las nociones de alienación, falta de poder y desesperanza aprendida son revisadas. Sesenta obreros de una empresa limeña fueron evaluados en términos del tipo de socialización dominante (SD y desesperanza aprendida (DA en sus tres áreas: falta de motivación, falta de control y expectativas de no-control en el futuro. Las escalas SD y DA resultaron consistentes. El análisis de regresión múltiple con las variables grado de división del trabajo, el grado de instrucción y –en migrantes- edad de arribo y permanencia en la capital, evidenció que el único predictor de DA es el grado de instrucción, correlacionándose negativamente. Los resultados se discuten a la luz de la realidad peruana.

  10. Uso de la metformina en la diabetes mellitus tipo II

    Directory of Open Access Journals (Sweden)

    Yohana Salazar ÁLvarez

    2011-03-01

    Full Text Available Metformina es una biguanida eficaz en el control metabólico de la diabetes mellitus tipo II, no insulinodependiente cuando el control dietético falla. Dada su probada eficacia y actual accesibilidad en el mercado de medicamentos en Cuba, para ser utilizada a nivel primario de atención no solo en pacientes sintomáticos sino en la población en riesgo, se presenta este artículo cuyo propósito es actualizar a los especialistas de Medicina General Integral y Medicina Interna acerca de aspectos de interés relacionados con este medicamento, como: interacciones medicamentosas, enfermedades concomitantes, la biotransformación de la droga y los posibles efectos adversos que se pueden asociar a su uso. Se presentan consideraciones finales acerca del uso de esta droga.

  11. Todo tipo de relacionamento consumidor-marca é eficiente?

    Directory of Open Access Journals (Sweden)

    Eliane Cristine Francisco-Maffezzolli

    2014-03-01

    Full Text Available O objetivo neste estudo foi investigar a existência de diferentes perfis de relacionamento consumidor-marca e sua respectiva eficiência na relação comercial. Três construtos da teoria de relacionamento com marcas foram avaliados: autoconexão, intimidade e interdependência com a marca. Foi realizado um survey com 441 casos. Os dados foram analisados por técnicas de cluster, fatorial e ANOVA. Três diferentes perfis foram encontrados: o relacionamento por inércia (RI, o qual sugere uma relação superficial e com menor poder de diferenciação sobre a marca; o relacionamento moderado (RM, o qual registrou avaliações intermediárias em todas as variáveis; o relacionamento verdadeiro (RV, o qual demonstra maior proximidade e conexão com a marca. Para verificar a eficiência desses tipos, foram avaliados os índices de satisfação, confiança, comprometimento e lealdade. Consumidores do tipo RI tendem a trocar de marca tão logo percebam vantagens maiores em outros concorrentes. Já os RM demonstram certa tendência de atitudes positivas em relação à marca, dependendo de seu contexto e oferta. O grupo RV demonstra maior tendência à continuidade do relacionamento. Do ponto de vista gerencial, perceber diferentes intensidades de relacionamento permite reconhecer que nem todo relacionamento é eficiente.

  12. Tipo de tratamiento farmacológico y deterioro de la función pulmonar en pacientes con diabetes tipo 2: un estudio de corte transversal

    OpenAIRE

    Henry A. Vargas; Martín Rondón; Rodolfo Dennis

    2016-01-01

    Introducción. La relación de la diabetes mellitus de tipo 2 con el deterioro de la función pulmonar no es clara, como tampoco si el tipo de tratamiento modifica los parámetros espirométricos e inflamatorios. Objetivo. Comparar la función pulmonar de pacientes con diabetes mellitus de tipo 2 tratados con un agente de sensibilización a la insulina (metformina) y de los tratados con secretagogos, así como de estos combinados con insulinas, y evaluar las diferencias en los biomarcadores de inf...

  13. Tipos de familia y su repercusión en la escuela /

    OpenAIRE

    Beti Alconada, Neri

    2015-01-01

    Se abordan los tipos de familia y su repercusión en la escuela. El trabajo está enfocado específicamente en la etapa de Educación Infantil y tiene como objetivo principal analizar los tipos de familia existentes en la actualidad y el tipo de repercusión que tienen estos modelos en la escuela infantil con el fin de proponer actividades para trabajar este tema

  14. Influence de l’anthropisation sur la végétation locale et l’abondance des tsé-tsé au sud du Burkina Faso*

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    Rayaissé J.B.

    2009-03-01

    Full Text Available Des enquêtes entomologiques couplées à une analyse phytosociologique ont été menées dans la zone de Folonzo au sud du Burkina Faso sur la rivière Comoé. L’étude avait pour objectif de comparer l’abondance et la diversité des espèces de glossines dans une zone protégée et une zone non protégée, grâce à des transects perpendiculaires au cours d’eau. Des pièges ont été posés le long de ces transects depuis la rivière Comoé jusqu’à la savane en passant par la galerie forestière. Une analyse diachronique de la zone entre 1980 et 2008 a également été menée par comparaison d’images satellites Landsat et à partir de l’évolution des densités de tsé-tsé. Sur chacun des transects, une description de la flore a été faite, incluant toutes les espèces situées dans un rayon de 10 m autour de chaque piège. Il existe une très grande homogénéité floristique entre les transects, particulièrement pour la forêt-galerie, en revanche la savane montre une relative hétérogénéité. L’enquête entomologique révèle la présence de quatre espèces de glossines qui sont Glossina tachinoides (74 %, G. morsitans submorsitans (20 %, G. palpalis gambiensis (4 % et G. medicorum (2 %. Une différence nette s’observe entre la zone non protégée et la zone protégée, avec une densité moyenne de tsé-tsé quatre fois inférieure dans la première. Cette différence est particulièrement importante pour G. m. submorsitans, dont les densités sont divisées par neuf dans la zone non protégée. Cette régression s’explique par la diminution de la faune sauvage hors de la zone protégée, et ceci est extrapolable à l’ensemble du pays où cette espèce de glossine est en net recul. L’évolution du terroir de Folonzo montre une augmentation impressionnante des densités humaines et des surfaces cultivées, qui n’a pas (encore d’impact visible sur la composition floristique des lieux d’analyse, mais qui

  15. EMISSÕES SOLARES TIPO-U E TIPO-J DECIMÉTRICAS REGISTRADAS PELO BRAZILIAN SOLAR SPECTROSCOPE (BSS

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    José Augusto S. S. Dutra

    2013-09-01

    Full Text Available Neste trabalho são apresentados os resultados da análise de cinco emissões solares tipo-U e tipo-J registradas pelo rádio espectrógrafo “Brazilian Solar Spectroscope” (BSS em frequências decimétricas (1,0 – 2,5 GHz, entre junho de 2000 e outubro de 2001. As características espectro-temporais das emissões foram medidas a partir dos espectros dinâmicos. Considerando a emissão de plasma no segundo harmônico, foram inferidos os seguintes parâmetros da fonte emissora: densidade de fluxo inferior a 20 – 80 u.f.s.; comprimento dos arcos magnéticos da ordem de (0,3 – 5,1 ´ 1010 cm; velocidade dos feixes de elétrons de (0,47 – 1,16 ´ 105 km/s; densidade máxima dos feixes de elétrons de (0,56 - 1,95 ´ 105 cm-3; máximo de (2,53 – 7,37 ´ 1031 elétrons no feixe; temperatura do topo dos arcos magnéticos de (2,5 – 15,5 ´ 106 K; e limite inferior para a intensidade do campo magnético na região do plasma confinado de 7 – 22 G. Os resultados são comparados com determinações publicadas na literatura.

  16. Alimentation et dépôts lipidiques chez la truite arc-en-ciel, effet de la température d’élevage

    OpenAIRE

    Corraze, Geneviève; Larroquet, Laurence; Médale, Françoise

    1999-01-01

    Cet article fait le point sur la régulation de la genèse des dépôts lipidiques par l’alimentation chez les poissons, sur la base de données bibliographiques existantes et de données personnelles obtenues chez la truite arc-en-ciel (Oncorhynchus mykiss). Chez la truite arc-en-ciel, l’importance quantitative des dépôts lipidiques corporels varie avec la teneur en lipides des aliments, mais les mécanismes de dépôts sont identiques quel que soit le régime alimentaire. Le tissu adipeux périviscéra...

  17. "edo jal̀qkina üts̀varòkaetus ma vaelda ..." : [luuletused] / Andreas Kalkun

    Index Scriptorium Estoniae

    Kalkun, Andreas, 1977-

    2002-01-01

    Sisu: "edo jal̀qkina üts̀varòkaetus ma vaelda ..." ; "tsirguq ku kiviq no satassõ taivast aràlaq ..." ; "vahtsõq silmäq pitsitä pääluu sisse ..." ; "tõppõ tõmmat haigõst ma haarõt jal̀ki ..." ; "arsatas njago sisse aigopiteh ..." ; "rühkeq yks jumalat pallõlda jaloh ..." ; "mu süä om no süüdläne täǹtäseq kuvvõ ..." ; "halvaq haavaq häitsese veiga silmih. Eluloolisi andmeid autori kohta lk. 379

  18. T-S Fuzzy Model Based Control Strategy for the Networked Suspension Control System of Maglev Train

    Directory of Open Access Journals (Sweden)

    Guang He

    2015-01-01

    Full Text Available The control problem for the networked suspension control system of maglev train with random induced time delay and packet dropouts is investigated. First, Takagi-Sugeno (T-S fuzzy models are utilized to represent the discrete-time nonlinear networked suspension control system, and the parameters uncertainties of the nonlinear model have also been taken into account. The controllers take the form of parallel distributed compensation. Then, a sufficient condition for the stability of the networked suspension control system is derived. Based on the criteria, the state feedback fuzzy controllers are obtained, and the controller gains can be computed by using MATLAB LMI Toolbox directly. Finally, both the numerical simulations and physical experiments on the full-scale single bogie of CMS-04 maglev train have been accomplished to demonstrate the effectiveness of this proposed method.

  19. Crossing the Ts by case-story “Exploring moral distress in potential sibling stem cell donors"

    DEFF Research Database (Denmark)

    Kaltoft, Mette Kjer

    Crossing the Ts by Exploring moral distress in potential sibling stem cell donors [1] Mette Kjer Kaltoft, Ph.d student, MPH, RN, Health Visitor University of Southern Denmark and Sydney School of Public Health Background: Catalysts aiming to reduce the burden of malignant disease by integrating...... research and practice in oncology battle for funding by communicating expected value created across the stakeholder chain. The media mirror supply and demand for novel life-prolonging treatment but not the molecular basis of uncertainty with different affinity receptors for decision makers and evidence...... sibling’s completed decision aid and explore one of your own by entering personal values and ratings. Implications for research and practice: Focusing on person-important outcomes can move forward translation backwards into research priorities. Open access web-based decision aids to transparent trading...

  20. Study on Application of T-S Fuzzy Observer in Speed Switching Control of AUVs Driven by States

    Directory of Open Access Journals (Sweden)

    Xun Zhang

    2014-01-01

    Full Text Available Considering the inherent strongly nonlinear and coupling performance of autonomous underwater vehicles (AUVs, the speed switching control method for AUV driven by states is presented. By using T-S fuzzy observer to estimate the states of AUV, the speed control strategies in lever plane, vertical plane, and speed kept are established, respectively. Then the adaptive switching law is introduced to switch the speed control strategies designed in real time. In the simulation, acoustic Doppler current profile/side scan sonar (ADCP/SSS observation case is employed to demonstrate the effectiveness of the proposed method. The results show that the efficiency of AUV was improved, the trajectory tracking error was reduced, and the steady-state ability was enhanced.

  1. Ectopic Anterior Mediastinal Pathology in the Chest: Radiologic-pathologic Correlation of Unexpected Encounters with the "Terrible Ts"

    Directory of Open Access Journals (Sweden)

    Mahsan Rashidfarokhi

    2016-01-01

    Full Text Available The complex embryology of the anterior mediastinum makes it home to an array of primary neoplasms tied to the presence of the thyroid and thymus glands in that compartment. While the occurrence of ectopic thyroid deposits in the extramediastinal thorax has not been convincingly established, the other three "Ts" of the classic "4T" mnemonic for the differential diagnosis of an anterior mediastinal mass have occurred in the lung parenchyma, pleural space, and endobronchially as primary tumors. Finding any of the three lesions - thymoma, teratoma, or B-cell lymphoma - in the chest outside the mediastinum is very unusual, but that possibility exists. Herein, we illustrate examples of this rare phenomenon.

  2. Biochemical Characterization and Validation of a Catalytic Site of a Highly Thermostable Ts2631 Endolysin from the Thermus scotoductus Phage vB_Tsc2631.

    Directory of Open Access Journals (Sweden)

    Magdalena Plotka

    Full Text Available Phage vB_Tsc2631 infects the extremophilic bacterium Thermus scotoductus MAT2631 and uses the Ts2631 endolysin for the release of its progeny. The Ts2631 endolysin is the first endolysin from thermophilic bacteriophage with an experimentally validated catalytic site. In silico analysis and computational modelling of the Ts2631 endolysin structure revealed a conserved Zn2+ binding site (His30, Tyr58, His131 and Cys139 similar to Zn2+ binding site of eukaryotic peptidoglycan recognition proteins (PGRPs. We have shown that the Ts2631 endolysin lytic activity is dependent on divalent metal ions (Zn2+ and Ca2+. The Ts2631 endolysin substitution variants H30N, Y58F, H131N and C139S dramatically lost their antimicrobial activity, providing evidence for the role of the aforementioned residues in the lytic activity of the enzyme. The enzyme has proven to be not only thermoresistant, retaining 64.8% of its initial activity after 2 h at 95°C, but also highly thermodynamically stable (Tm = 99.82°C, ΔHcal = 4.58 × 10(4 cal mol(-1. Substitutions of histidine residues (H30N and H131N and a cysteine residue (C139S resulted in variants aggregating at temperatures ≥75°C, indicating a significant role of these residues in enzyme thermostability. The substrate spectrum of the Ts2631 endolysin included extremophiles of the genus Thermus but also Gram-negative mesophiles, such as Escherichia coli, Salmonella panama, Pseudomonas fluorescens and Serratia marcescens. The broad substrate spectrum and high thermostability of this endolysin makes it a good candidate for use as an antimicrobial agent to combat Gram-negative pathogens.

  3. Biochemical Characterization and Validation of a Catalytic Site of a Highly Thermostable Ts2631 Endolysin from the Thermus scotoductus Phage vB_Tsc2631.

    Science.gov (United States)

    Plotka, Magdalena; Kaczorowska, Anna-Karina; Morzywolek, Agnieszka; Makowska, Joanna; Kozlowski, Lukasz P; Thorisdottir, Audur; Skírnisdottir, Sigurlaug; Hjörleifsdottir, Sigridur; Fridjonsson, Olafur H; Hreggvidsson, Gudmundur O; Kristjansson, Jakob K; Dabrowski, Slawomir; Bujnicki, Janusz M; Kaczorowski, Tadeusz

    2015-01-01

    Phage vB_Tsc2631 infects the extremophilic bacterium Thermus scotoductus MAT2631 and uses the Ts2631 endolysin for the release of its progeny. The Ts2631 endolysin is the first endolysin from thermophilic bacteriophage with an experimentally validated catalytic site. In silico analysis and computational modelling of the Ts2631 endolysin structure revealed a conserved Zn2+ binding site (His30, Tyr58, His131 and Cys139) similar to Zn2+ binding site of eukaryotic peptidoglycan recognition proteins (PGRPs). We have shown that the Ts2631 endolysin lytic activity is dependent on divalent metal ions (Zn2+ and Ca2+). The Ts2631 endolysin substitution variants H30N, Y58F, H131N and C139S dramatically lost their antimicrobial activity, providing evidence for the role of the aforementioned residues in the lytic activity of the enzyme. The enzyme has proven to be not only thermoresistant, retaining 64.8% of its initial activity after 2 h at 95°C, but also highly thermodynamically stable (Tm = 99.82°C, ΔHcal = 4.58 × 10(4) cal mol(-1)). Substitutions of histidine residues (H30N and H131N) and a cysteine residue (C139S) resulted in variants aggregating at temperatures ≥75°C, indicating a significant role of these residues in enzyme thermostability. The substrate spectrum of the Ts2631 endolysin included extremophiles of the genus Thermus but also Gram-negative mesophiles, such as Escherichia coli, Salmonella panama, Pseudomonas fluorescens and Serratia marcescens. The broad substrate spectrum and high thermostability of this endolysin makes it a good candidate for use as an antimicrobial agent to combat Gram-negative pathogens.

  4. Synthesis and morphology research of framework Ti-rich TS-1 containing no extraframework Ti species in the presence of CO2

    KAUST Repository

    Zhu, Guowei

    2014-02-01

    A new method to synthesis TS-1 has been developed using the carbon dioxide (CO2) as an alkalinity regulator that resulted in the increased framework Ti contents. The prepared catalyst had a Si/Ti ratio as low as 40 in contrast to the ratio of 56 prepared through conventional synthesis. The twin crystals with the length of 2 μm were formed via introduction of CO 2. The catalytic activity of TS-1 is remarkably enhanced compared with the conventional synthesis. © 2013 Elsevier B.V.

  5. Estresse em mulheres com Diabetes mellitus tipo 2

    Directory of Open Access Journals (Sweden)

    Juliana Cristina Lessmann

    2011-06-01

    Full Text Available OBJETIVO: O objetivo do estudo foi investigar a relação entre estresse e Diabetes Mellitus Tipo 2 em mulheres. MÉTODO: Estudo transversal prospectivo, desenvolvido com 147 mulheres, utilizando a Escala de Estresse Percebido (PSS. RESULTADOS: Houve associação entre as variáveis testadas, sendo possível inferir que as mulheres com estresse elevado são as que vivenciaram sofrimento e apresentam controle glicêmico alterado, ou seja, com valores superiores a 180 mg/dL. A maioria relatou sofrimento decorrente de problemas nas relações interpessoais, óbito, doença de familiares e solidão. CONCLUSÃO: Mulheres com DM2 que convivem com estresse e/ou sofrimento constituem grupo vulnerável ao desenvolvimento de agravos à saúde demandando aos serviços de saúde o desenvolvimento de estratégias que modifiquem esta situação.

  6. Tratamento Medicamentoso da Hiperglicemia no Diabetes Melito Tipo 2

    Directory of Open Access Journals (Sweden)

    Letícia Schwerz Weinert

    2011-01-01

    Full Text Available O diabetes melito tipo 2 (DM2 decorre de alteração na ação e secreção de insulina. A longo prazo, a elevação da glicemia promove dano microvascular, neuropatia e dano macrovascular, com consequente aumento da morbi-mortalidade destes pacientes. Nas últimas décadas, diversos ensaios clínicos clássicos demonstraram que intervenções terapêuticas específicas para corrigir a hiperglicemia e hipertensão arterial são capazes de prevenir ou retardar o avanço das complicações crônicas. Neste sentido, tratamento efetivo e da forma mais precoce possível deve ser oferecido a todos os pacientes com DM2. Fármacos antiobesidade e agentes orais, como a metformina, sulfonilureias, glinidas, tiazolidinedionas, inibidores da alfa-glicosidase, e os mais recentes fármacos incretinomiméticos e amilinomiméticos são apresentados nessa revisão, nos aspectos de mecanismos de ação, efeitos colaterais e contraindicações.

  7. Identification of mutations in the genome of rotavirus SA11 temperature-sensitive mutants D, H, I and J by whole genome sequences analysis and assignment of tsI to gene 7 encoding NSP3.

    Science.gov (United States)

    Vende, Patrice; Gratia, Matthieu; Duarte, Mariela D; Charpilienne, Annie; Saguy, Matthieu; Poncet, Didier

    2013-09-01

    The complete coding sequences of the four unassigned temperature-sensitive (ts) Baylor prototype rotavirus mutants (SA11ts D, H, I and J) were sequenced by deep sequencing double-stranded RNA using RNA-seq. Non-silent mutations were assigned to a specific mutant by Sanger sequencing RT-PCR products from each mutant. Mutations that led to amino acid changes were found in all genes except for genes 1 (VP1), 10 (NSP4) and 11 (NSP5/6). Based on these sequence analyses and earlier genetic analyses, the ts mutations in gene 7, which encodes the protein NSP3, were assigned to ts mutant groups I and H, and confirmed by an in vitro RNA-binding assay with recombinant proteins. In addition, ts mutations in gene 6 were assigned to tsJ. The presence of non-conservative mutations in two genes of two mutants (genes 4 and 2 in tsD and genes 3 and 7 in tsH) underscores the necessity of sequencing the whole genome of each rotavirus ts mutant prototype. Copyright © 2013 Elsevier B.V. All rights reserved.

  8. Funcionamiento psicofisiológico y susceptibilidad a la sintomatología premenstrual en mujeres Tipo A y Tipo B

    Directory of Open Access Journals (Sweden)

    Francesc Palmero

    2002-01-01

    Full Text Available El presente trabajo se centra en explorar el papel que juega el componente emocional del Patrón de Conducta Tipo A (PCTA en diversas áreas relacionadas con la salud. En este contexto nuestra investigación desarrolla dos objetivos diferenciados. El primero trata de constatar la relación entre determinadas características del PCTA y el mecanismo psicofisiológico en una tarea experimental de estrés real (situación de examen, considerando si existen diferencias entre los dos grupos de personas, Tipo A y Tipo B, tanto en la dimensión tónica como en la dimensión fásica de la tasa cardiaca. El segundo de nuestros objetivos trata de establecer la relación existente entre determinadas características del PCTA y la experiencia de sintomatología relacionada con el ciclo menstrual, considerando tanto la sintomatología premenstrual global, como la sintomatología premenstrual específica, diferenciando tres grandes grupos de síntomas: fisiológicos, psicológicos y conductuales. La muestra final estuvo conformada por 28 mujeres Tipo A y 29 mujeres Tipo B. Los instrumentos utilizados fueron el inventario de Actividad de Jenkins (JAS, el calendario menstrual de síntomas de registro diario (CMSRD y un polígrafo que permitió registrar la tasa cardiaca. En cuanto a nuestro primer objetivo, los datos hacen pensar en la existencia de distintos perfiles psicofisiológicos en ambos grupos de mujeres; en el segundo objetivo, parece que las mujeres Tipo A experimentan de forma clara más síntomas psicológicos que las mujeres Tipo B.

  9. Impacts des évolutions démographiques et climatiques sur la répartition spatiale des hommes, des tsé-tsé et des trypanosomoses en Afrique de l’Ouest*

    Directory of Open Access Journals (Sweden)

    Courtin F.

    2009-03-01

    Full Text Available Les évolutions démographiques (population humaine multipliée par quatre en 50 ans, les changements climatiques et le développement économique survenus en Afrique de l’Ouest depuis maintenant un siècle ont profondément modifié le peuplement humain et les paysages dans lesquels il s’inscrit. Ces évolutions ne sont pas sans conséquences sur le complexe pathogène des trypanosomoses transmises par les glossines. En l’espace d’un siècle, la limite nord des tsé-tsé s’est déplacée vers le sud, accompagnant (mais à des échelles distinctes la descente des isohyètes et des foyers de maladie du sommeil, autrefois présents en savane et qui sont actuellement répartis en zone forestière et en zone de mangrove. On met en évidence un impact clair de la pression anthropique sur le recul des glossines du groupe morsitans, vecteurs majeurs des trypanosomoses animales. En revanche, les glossines du groupe palpalis (notamment Glossina palpalis s’adaptent aux fortes densités humaines et se maintiennent dans les plus grands centres urbains d’Afrique de l’Ouest, posant d’ailleurs la question du développement de foyers urbains dans les années à venir, comme en témoigne l’exemple récent de Kinshasa. L’étude des facteurs humains (dynamiques de peuplement et environnementaux (changements climatiques et leurs impacts dans l’espace et dans le temps, corrélée à celle des trypanosomoses et de leurs vecteurs devra permettre la mise en évidence des combinaisons spatiales capables d’expliquer la présence/absence de la maladie dans le but d’orienter les zones d’intervention médicale et anti-vectorielle. Ce type d’étude pourra être étendu à d’autres pathologies transmises par des vecteurs.

  10. Tipo de parto: expectativas das mulheres Tipo de parto: expectativas de las mujeres Childbirth types: women's expectations

    Directory of Open Access Journals (Sweden)

    Sonia Maria Junqueira Vasconcellos de Oliveira

    2002-10-01

    Full Text Available Estudo descritivo e exploratório, realizado mediante entrevista com 221 puérperas que tiveram parto em maternidades públicas estaduais, localizadas no município de São Paulo. Teve como objetivos: 1. identificar o tipo de parto esperado pelas mulheres, considerando a via vaginal ou cesariana, e sua justificativa; 2. verificar a ocorrência do tipo de parto, segundo as expectativas dessas mulheres; 3. comparar a indicação médica da cesariana com o entendimento das mulheres sobre justificativa dessa intervenção. Os dados revelam que 74,7% tinham expectativa de que o parto fosse normal, e 25,3%, de que fosse cesárea. O parto normal, esperado por 165 entrevistadas, ocorreu em 66,1% dessas mulheres. A justificativa mais citada pelas mulheres para esperar o parto normal foi a recuperação pós-parto mais rápida e, para a cesárea, ter tido cesárea anterior. As justificativas apresentadas por 61 mulheres para a realização da cesariana não era coincidente com a indicação médica em 47,5% dos casos.Estudio descriptivo y exploratorio, realizado mediante entrevista con 221 puerperas que tuvieron el parto en maternidades públicas de en la ciudad de São Paulo. La investigación tuvo como objetivos: 1. identificar el tipo de parto esperado por las mujeres, considerando la vía vaginal o cesárea y su justificación; 2. verificar la ocurrencia del tipo de parto, según las expectativas de esas mujeres; 3. comparar la indicación médica da la cesárea con la comprensión de las mujeres sobre la justificación para esa intervención. Los datos muestran que 74,7% de las mujeres tenían la expectativa de que el parto fuese normal y 25,3% que fuese cesárea. El parto normal, esperado por 165 entrevistadas, ocurrió en 66,1% de estas mujeres. La justificativa más utilizada por las mujeres para esperar el parto normal fue la recuperación postparto más rápida y para la cesárea, haber tenido la cesárea anterior. La justificación presentada

  11. Implantes inmediatos transalveolares tipo IMETI®. Reporte de un caso

    Directory of Open Access Journals (Sweden)

    Joyce Barrios Mejía

    2013-10-01

    Full Text Available ResumenHoy en día existen avances en el concepto de mantenimiento y regeneración ósea. Es bien conocido en el ámbito de la odontología que tras una exodoncia se produce una reabsorción del alveolo residual dentro del mismo proceso de cicatrización y remodelación gingival y ósea, pero para evitar estos inconvenientes se plantean los implantes inmediatos insertados en el mismo acto quirúrgico en el cual se extrae el diente a sustituir. Con respecto a los implantes diferidos, tienen precisamente la ventaja de disminuir la continua reabsorción ósea del alveolo postextracción, acortar el tiempo de tratamiento rehabilitador y evitar segundas cirugías de implantación. El objetivo de este artículo es caracterizar a través de un caso el éxito de esta técnica quirúrgica con la convencional utilizando los implantes tipo IMETI ®. (Duazary 2007; 1: 45 - 51AbstractNow a days exists an advance in the maintenance concept and bony regeneration. is very well-known that after an exodontic a reabsorption of the residual alveolus takes place inside the same scaring process and gingival remodeling and bony, to avoid these inconveniences, it is thought about the immediate implant inserted in the same surgical act in which the tooth to substitute is extracted. With regard the differed implants; they have the advantage of diminishing the continuous bony reabsorption of the alveolus post-extraction, to shorten the time of rehabilitative treatment and to avoid second implantation surgeries. The objective of the present case, is to characterize the success of this surgical technique with the conventional used the IMETI ® implants.Key Words: Extraction; Implant; Alveolus; IMETI ®

  12. O uso de politetrafluoroetileno expandido em tireoplastia tipo I

    Directory of Open Access Journals (Sweden)

    Mello-Filho Francisco Veríssimo de

    2003-01-01

    Full Text Available A paralisia unilateral de prega vocal (PUPV em abdução é uma alteração que produz grande desconforto ao paciente, principalmente pelos distúrbios fonatórios causados. Atualmente dispomos de uma variedade de métodos para seu tratamento. OBJETIVO: Verificar a eficiência, vantagens e desvantagens do uso da fita de politetrafluoretileno expandido (PTFE-e, na medialização de prega vocal (PV paralisada, em abdução. FORMA DE ESTUDO: Coorte Longitudinal. MATERIAL E MÉTODOS: Foram estudados quatro pacientes com diagnóstico clínico-laringoscópico de disfonia por PPVU, em abdução há pelo menos um ano. Os pacientes foram submetidos a avaliação fonoaudiológica e a tireoplastia tipo I para medialização da PV com fita de PTFE-e. Durante o seguimento pós-operatório procedeu-se videolaringoscopia, tomografia computadorizada e fonoterapia. RESULTADOS: Todos os pacientes estão satisfeitos com a qualidade vocal, apresentam medialização estável da PV com a fonocirurgia e bons resultados à avaliação fonoaudiológica. Um paciente apresentou extrusão intra-operatória da fita de PTFE-e, sendo feito um segundo procedimento, sem complicações, seis meses depois. CONCLUSÃO: Na opinião dos autores a fita de PTFE-e se presta com eficiência ao tratamento da PUPV, sem apresentar riscos importantes.

  13. Intervenciones Farmaceuticas en pacientes con Diabetes Mellitus Tipo 2

    Directory of Open Access Journals (Sweden)

    Gladys Mabel Maidana

    Full Text Available Resumen Introducción: La Atención Farmacêutica es la provision responsable de la farmacoterapia con el propósito de alcanzar resultados concretos que mejoren la calidad de vida de los pacientes. Objetivo: Evaluar el impacto de las intervenciones farmacéuticas en pacientes con Diabetes Mellitus Tipo 2. Metodologia: Ensayo Clínico Aleatorizado, con medición de variables antes y después. No probabilísti-co. De conveniencia. Participaron 32 pacientes del grupo intervenido y 32 en grupo control. Se realizaron entrevistas mensuales en un periodo de intervención farmacéutica de 6 meses (desde octubre 2011 hasta junio 2012. Se registraron solo 3 abandonos. Resultados: La edad de los pacientes fue 55,6±10,6 anos. Los pacientes del grupo intervenido mejoraron la glicemia en 34%, donde 24 pacientes tenian el valor (< 130 mg/dL; la hemoglobina glicosilada mejoró 1,9%, donde 15 pacientes lograron los parámetros deseados (< 6,5%. La calidad de vida del grupo inter-venido aumentó de (56,3 a 71,3 % y fue medido con el cuestionario SF-36. En el grupo intervenido se encontraron 80 problemas relacionados con medicamentos, en 27 pacientes, se resolvieron 59; al final del estudio 12 pacientes resolvieron todos los problemas relacionados con medicamentos; se realizaron 254 intervenciones farmacêuticas, el nivel de conocimiento de los pacientes sobre la enfermedad mejoró en 41%, el conocimiento sobre sus medicamentos mejoró en 53%. Conclusión: Las intervenciones farmacêuticas mejoraron los parámetros clínicos de glicemia, hemoglobina glicosilada, optimizaron el uso de medicamentos, disminuyeron los problemas relacionados con medicamentos, mejoraron la calidad de vida de los pacientes.

  14. Psychometric properties of the Portuguese version of the Acceptance and Action Questionnaire-Trauma Specific (AAQ-TS): A study with Portuguese Colonial War Veterans.

    Science.gov (United States)

    Pinto-Gouveia, José; Carvalho, Teresa; Cunha, Marina; Duarte, Joana; Walser, Robyn D

    2015-10-01

    The Acceptance and Action Questionnaire-Trauma Specific (AAQ-TS) is a self-report measure designed to assess-trauma-related psychological (in)flexibility, as conceptualized in Acceptance and Commitment Therapy. However, there are no studies to date regarding its psychometric properties. This study explores such properties in the Portuguese version of the AAQ-TS, in Portuguese Colonial War Veterans. A Principal Components Analysis (PCA) was conducted in a sample from the general population of war Veterans (N=371). Confirmatory Factor Analysis (CFA) as well as reliability and convergent validity studies were performed in a different sample from the same population (N=312). For the discriminant validity a clinical sample with a war-related PTSD (N=42) and a non-clinical sample without PTSD (N=44) were used. The CFA suggested a re-specified 15-item model with good global adjustment and factorial validity. The AAQ-TS showed internal consistency, a good temporal reliability, convergent validity with psychopathological symptoms (related to PTSD, anxiety, depression and stress) and peritraumatic dissociation (altered awareness and depersonalization/derealization). The questionnaire also discriminates between war Veterans with and without a PTSD diagnosis. The major limitation relates to the samples' characteristics and sampling methods, which can limit the generalization of results. The Portuguese version of the AAQ-TS is a reliable and valid measure to assess experiential avoidance related to trauma in Portuguese Colonial War Veterans. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Teacher Salary Comparisons--Inter-City Differences: 2010-11 and 2011-12. BCTF Research Report. Section I. 2012-TS-02

    Science.gov (United States)

    White, Margaret

    2012-01-01

    This research report, which is an update of research report 2011-TS-03, shows the salary difference for each step of British Columbia's (BC) Category 5 or comparable qualifications. Salaries for Vancouver public school teachers are compared to teacher salaries in Toronto (elementary), Ottawa (secondary), and Edmonton. Salaries for Prince George…

  16. Evaluation of Beef by Electronic Tongue System TS-5000Z: Flavor Assessment, Recognition and Chemical Compositions According to Its Correlation with Flavor.

    Directory of Open Access Journals (Sweden)

    Xinzhuang Zhang

    Full Text Available The aim of this study was to assess the ability of electronic tongue system TS-5000Z to evaluate meat quality based on flavor assessment, recognition and correlation with the meat chemical composition. Meat was sampled from eighteen beef cattle including 6 Wagyu breed cattle, 6 Angus breed cattle and 6 Simmental breed cattle. Chemical composition including dry matter, crude protein, fat, ash, cholesterol and taurine and flavor of the meat were measured. The results showed that different breed cattle had different chemical compositions and flavor, which contains sourness, umami, saltiness, bitterness, astringency, aftertaste from astringency, aftertaste from bitterness and aftertaste from umami, respectively. A principal component analysis (PCA showed an easily visible separation between different breeds of cattle and indicated that TS-5000Z made a rapid identification of different breeds of cattle. In addition, TS-5000Z seemed to be used to predict the chemical composition according to its correlation with the flavor. In conclusion, TS-5000Z would be used as a rapid analytical tool to evaluate the beef quality both qualitatively and quantitatively, based on flavor assessment, recognition and chemical composition according to its correlation with flavor.

  17. Les dégâts de la grêle sur les cultures: l'averse du 1er juin 1993 dans le Saumurois

    Directory of Open Access Journals (Sweden)

    Freddy VINET

    1994-12-01

    Full Text Available La cartographie fine des dégâts de la grêle sur le vignoble du Saumurois permet d’obtenir des informations intéressantes sur le déroulement des averses de grêle: phase de concentration, coeur de grêle, dissipation.

  18. An improved FEM model for computing transport AC loss in coils made of RABiTS YBCO coated conductors for electric machines

    DEFF Research Database (Denmark)

    Ainslie, Mark D; Rodriguez Zermeno, Victor Manuel; Hong, Zhiyong

    2011-01-01

    and magnetic field-dependent critical current densities, and the inclusion and exclusion of a magnetic substrate, as found in RABiTS (rolling-assisted biaxially textured substrate) YBCO coated conductors. The coil model is based on the superconducting stator coils used in the University of Cambridge EPEC...

  19. A Heuristic T-S Fuzzy Model for the Pumped-Storage Generator-Motor Using Variable-Length Tree-Seed Algorithm-Based Competitive Agglomeration

    Directory of Open Access Journals (Sweden)

    Jianzhong Zhou

    2018-04-01

    Full Text Available With the fast development of artificial intelligence techniques, data-driven modeling approaches are becoming hotspots in both academic research and engineering practice. This paper proposes a novel data-driven T-S fuzzy model to precisely describe the complicated dynamic behaviors of pumped storage generator motor (PSGM. In premise fuzzy partition of the proposed T-S fuzzy model, a novel variable-length tree-seed algorithm based competitive agglomeration (VTSA-CA algorithm is presented to determine the optimal number of clusters automatically and improve the fuzzy clustering performances. Besides, in order to promote modeling accuracy of PSGM, the input and output formats in the T-S fuzzy model are selected by an economical parameter controlled auto-regressive (CAR model derived from a high-order transfer function of PSGM considering the distributed components in the water diversion system of the power plant. The effectiveness and superiority of the T-S fuzzy model for PSGM under different working conditions are validated by performing comparative studies with both practical data and the conventional mechanistic model.

  20. The Ts65Dn mouse model of Down syndrome shows reduced expression of the Bcl-X(L) antiapoptotic protein in the hippocampus not accompanied by changes in molecular or cellular markers of cell death.

    Science.gov (United States)

    Rueda, Noemí; Flórez, Jesús; Martínez-Cué, Carmen

    2011-11-01

    The Ts65Dn (TS) mouse, the most widely used model of Down syndrome (DS), has a partial trisomy of a segment of chromosome 16 that is homologous to the distal part of human chromosome 21. This mouse shares many phenotypic characteristics with people with DS including neuromorphological, neurochemical, and cognitive disturbances. Both TS and DS brains show earlier aging and neurodegeneration. Since fibroblast cultures from TS mice and human DS hippocampal regions show increased apoptotic cell death it has been suggested that alterations in cerebral apoptosis might be implicated in the cognitive deficits found in TS mice and in people with DS. In the present study we have evaluated brain expression levels of several proapoptotic and antiapoptotic proteins from the mitochondrial (Bcl-2, Bcl-X(L), Bax and Bad) and the extrinsic (Fas-R and Fas-L) apoptotic pathways as well as the final executioner caspase-3, in the cortex and hippocampus of TS mice. No significant alterations in the expression levels of the proapoptotic Bad and Bax or the antiapoptotic Bcl-2 proteins in the cortex or hippocampus were found in TS mice. However, TS mice showed downregulation of Bcl-X(L) in the hippocampus. In the extrinsic pathway we found unchanged levels of Fas-L in both structures and also in the expression levels of Fas-R in the hippocampus. Although Bcl-X(L) downregulation suggests that the hippocampus of TS mice is less protected against programmed cell death, we did not find any evidence for increased apoptosis in TS mice since neither TUNEL-positive cells nor active caspase-3 expression were found in cortex or hippocampus of TS or CO mice. Copyright © 2011 ISDN. Published by Elsevier Ltd. All rights reserved.

  1. Technical principles underlying limit values for release of substances for the percolation test TS3: comparison DE and NL

    Energy Technology Data Exchange (ETDEWEB)

    Van Zomeren, A.; Dijkstra, J.J. [ECN Environment and Energy Engineering, Petten (Netherlands); Susset, B. [Consulting Office SiWaP (Germany)

    2013-10-15

    Within CEN TC 351 WG 1, standardized, horizontal test methods are developed to assess the release (leaching) of dangerous substances from construction as defined in ER3 of the CPD. For granular materials TS 3, a horizontal up-flow percolation test, was further developed by CEN TC 351 WG1 and will enter the validation phase in 2013. In CEN TC 351 WG1, there are still discussions regarding the sample preparation and some test conditions. Currently, two options for sample preparation and test conditions are specified. Controversy between DE and NL regarding sample preparation and test conditions and the need for two separate options in the TS 3 percolation test are possibly for a part caused by different approaches for risk assessment in the Netherlands and in Germany and the resulting regulatory concepts. One important reason for this is, that in soil and groundwater regulations the test method and the impact assessment method are systematically linked together but the impact assessment methods and lab methods in both countries are different. The discussions in CEN TC 351 WG 1 show that there is a need to have a better mutual understanding of the relation between test method and impact assessment on the one hand and a clear overview of differences in impact assessment approaches of each country on the other hand. The aim of this project is to explain and compare the assumptions, boundary conditions and conventions of the impact assessment approach that are implemented in the upcoming German Recycling Degree and in the Soil Quality Degree of the Netherlands. Ultimately, a better understanding of the impact assessment approaches provides a basis for further discussion in WG1 to agree on only one option for the percolation test conditions. The following report is prepared by the contractors of Germany and Netherlands together to compare the two country-specific concepts. This report summarizes and explains the presentation given on the 25th of April at TC 351 WG1 in

  2. 333. Procedimiento Híbrido Emergente en Disección Aguda Tipo B Stanford Tipo III

    Directory of Open Access Journals (Sweden)

    C. Velasco García de Sierra

    2012-04-01

    Paciente de 54 años que acude al servicio de urgencias por dolor dorsal y abdominal de reciente comienzo, e isquemia crítica de miembro inferior izquierdo. En TC se objetivó disección aguda tipo B con una gran puerta de entrada proximal al origen de la arteria subclavia izquierda (ASI y con extensión distal a los vasos viscerales y ambas arterias ilíacas. Presentaba inestabilidad hemodinámica y acidosis metabólica en relación con isquemia visceral. A través de esternotomía media se realizó translocación de ASI y arteria carótida izquierda a aorta ascendente, consiguiéndose una zona de anclaje proximal segura para una endoprótesis (34 × 150 mm. El control postoperatorio confirmó la correcta colocación de la misma con recuperación de la perfusión visceral y renal, pero sin mejoría de la isquemia de miembro inferior que precisó realización de bypass femorofemoral cruzado. En el postoperatorio presentó fracaso renal agudo, neumonía y taponamiento cardíaco, siendo necesaria pericardiocentesis. El paciente fue dado de alta tras 40 días de ingreso hospitalario con labetalol para control de su hipertensión arterial (HTA y continúa bien tras 1 año de seguimiento.

  3. Influencia del contacto precoz, nacionalidad, tipo de parto y prematuridad en la lactancia materna

    OpenAIRE

    Ana Belén Laviña Castan

    2015-01-01

    Conocer si en el HUMS existe asociación entre lactancia materna y nacionalidad, prematuridad, tipo de parto, contacto precoz piel con piel. Estudio de cohortes, en una muestra de 541 puérperas del HUMS en octubre-noviembre 2011. Las variables: nacionalidad, tipo de parto, contacto precoz, parto prematuro e inicio lactancia materna se recogieron antes del alta hospitalaria mediante cuestionario. A los dos meses postparto se contactó telefónicamente con las madres para conocer el tipo de lactan...

  4. Diseño de antenas tipo DRA (Dielectric Resonator Antennas)

    OpenAIRE

    Soria Gallego, Juan

    2013-01-01

    En este trabajo se va a estudiar un tipo de antenas conocidas como antenas resonantes dieléctricas (DRA) desde el punto de vista de diseño y características radiantes, así como de sus posibles aplicaciones. Las DRAs son un tipo de antenas cada vez más usadas ya que presentan numerosas ventajas respecto a otro tipo de antenas, entre ellas que son fáciles de diseñar, baratas y muy eficientes. Por ello, cada vez aparecen nuevos diseños y nuevas aplicaciones. Entre ellas se ha extendido el uso...

  5. Medidas antropométricas orofaciais de crianças segundo o tipo facial

    OpenAIRE

    Berwig,Luana Cristina; Figueiredo,Fernanda Sartori Pedrotti; Bolzan,Geovana de Paula; Milanesi,Jovana de Moura; Marquezan,Mariana; Busanello-Stella,Angela Ruviaro; Silva,Ana Maria Toniolo da

    2017-01-01

    RESUMO Objetivo: avaliar as medidas antropométricas orofaciais segundo o tipo facial de crianças do sexo masculino e feminino. Métodos: participaram do estudo 126 crianças, 64 do sexo feminino e 62 do sexo masculino, com idade entre sete anos e 11 anos. As medidas antropométricas orofaciais foram comparadas entre os tipos faciais obtidos por meio da análise cefalométrica. Inicialmente foi realizada análise descritiva dos tipos faciais de acordo com os sexos. Por meio da Análise de Variânc...

  6. Optimized Energy Harvesting, Cluster-Head Selection and Channel Allocation for IoTs in Smart Cities

    Directory of Open Access Journals (Sweden)

    Saleem Aslam

    2016-12-01

    Full Text Available This paper highlights three critical aspects of the internet of things (IoTs, namely (1 energy efficiency, (2 energy balancing and (3 quality of service (QoS and presents three novel schemes for addressing these aspects. For energy efficiency, a novel radio frequency (RF energy-harvesting scheme is presented in which each IoT device is associated with the best possible RF source in order to maximize the overall energy that the IoT devices harvest. For energy balancing, the IoT devices in close proximity are clustered together and then an IoT device with the highest residual energy is selected as a cluster head (CH on a rotational basis. Once the CH is selected, it assigns channels to the IoT devices to report their data using a novel integer linear program (ILP-based channel allocation scheme by satisfying their desired QoS. To evaluate the presented schemes, exhaustive simulations are carried out by varying different parameters, including the number of IoT devices, the number of harvesting sources, the distance between RF sources and IoT devices and the primary user (PU activity of different channels. The simulation results demonstrate that our proposed schemes perform better than the existing ones.

  7. Optimized Energy Harvesting, Cluster-Head Selection and Channel Allocation for IoTs in Smart Cities.

    Science.gov (United States)

    Aslam, Saleem; Hasan, Najam Ul; Jang, Ju Wook; Lee, Kyung-Geun

    2016-12-02

    This paper highlights three critical aspects of the internet of things (IoTs), namely (1) energy efficiency, (2) energy balancing and (3) quality of service (QoS) and presents three novel schemes for addressing these aspects. For energy efficiency, a novel radio frequency (RF) energy-harvesting scheme is presented in which each IoT device is associated with the best possible RF source in order to maximize the overall energy that the IoT devices harvest. For energy balancing, the IoT devices in close proximity are clustered together and then an IoT device with the highest residual energy is selected as a cluster head (CH) on a rotational basis. Once the CH is selected, it assigns channels to the IoT devices to report their data using a novel integer linear program (ILP)-based channel allocation scheme by satisfying their desired QoS. To evaluate the presented schemes, exhaustive simulations are carried out by varying different parameters, including the number of IoT devices, the number of harvesting sources, the distance between RF sources and IoT devices and the primary user (PU) activity of different channels. The simulation results demonstrate that our proposed schemes perform better than the existing ones.

  8. Optimized Energy Harvesting, Cluster-Head Selection and Channel Allocation for IoTs in Smart Cities

    Science.gov (United States)

    Aslam, Saleem; Hasan, Najam Ul; Jang, Ju Wook; Lee, Kyung-Geun

    2016-01-01

    This paper highlights three critical aspects of the internet of things (IoTs), namely (1) energy efficiency, (2) energy balancing and (3) quality of service (QoS) and presents three novel schemes for addressing these aspects. For energy efficiency, a novel radio frequency (RF) energy-harvesting scheme is presented in which each IoT device is associated with the best possible RF source in order to maximize the overall energy that the IoT devices harvest. For energy balancing, the IoT devices in close proximity are clustered together and then an IoT device with the highest residual energy is selected as a cluster head (CH) on a rotational basis. Once the CH is selected, it assigns channels to the IoT devices to report their data using a novel integer linear program (ILP)-based channel allocation scheme by satisfying their desired QoS. To evaluate the presented schemes, exhaustive simulations are carried out by varying different parameters, including the number of IoT devices, the number of harvesting sources, the distance between RF sources and IoT devices and the primary user (PU) activity of different channels. The simulation results demonstrate that our proposed schemes perform better than the existing ones. PMID:27918424

  9. Spontaneous and artificial generation of sheared flow in oblate FRCs in TS-3 and 4 FRC experiments

    International Nuclear Information System (INIS)

    Matsuyama, T.; Kawamori, E.; Ono, Y.; Tsuruda, M.; Sato, K.; Yamanoue, T.; Arimoto, K.; Itagaki, T.; Katsurai, M.

    2003-01-01

    Spontaneous formation of toroidal flow was measured for the first time in oblate FRCs produced in TS-3 and 4 experiments. The toroidal ion flow (V i ∼10km/sec) was found to peak around the magnetic axis, indicating formation of high flow shear inside the separatrix. The toroidal flow was observed to deform the magnetic field lines of the FRC, producing bipolar toroidal field profile. In high-s FRC (averaged number of ion gyro-radius 's'=4.5) with slow flow, its n=1 mode kept growing, causing collapse of the whole configuration. However, in low-s FRC (s=3) with fast flow, the rotating n=2 mode (saturated) became dominant after n=1 mode saturation. The spontaneous formation of flow shear possibly transformed the n=1 mode into the n=2 mode, suggesting a new sheared flow stabilization of n=1 mode. The flow shear was also generated artificially using the 'sling shot' effect of the counter helicity reconnection. The n=1 and 2 mode amplitudes were reduced down to 1/5-1/10 due to the generated flow shear. A new method for continuous sheared-flow generation was proposed for stabilization and heating of FRC by use of intermittent merging of spheromaks with opposing B t . (author)

  10. Actividad hidráulica de un cemento belítico obtenido a partir de cenizas volantes tipo C: influencia del aditivo y tipo de curado

    OpenAIRE

    Goñi, S.; Guerrero, A.

    2006-01-01

    En este trabajo se discute la influencia del tipo de curado y de un aditivo reductor de la demanda de agua en la actividad hidráulica de un cemento belítico de cenizas volantes de alto contenido en cal denominado (CBCV-2-A). Este cemento ha sido sintetizado por una ruta húmeda hidrotermal con posterior calcinación, empleando ceniza volante de alto contenido en cal (ASTM tipo C) como materia prima. La actividad hidráulica se ha estudiado en la pasta de cemento, durante un periodo de 180 días, ...

  11. Actividad hidráulica de un cemento belítico obtenido a partir de cenizas volantes tipo C: influencia del aditivo y tipo de curado

    OpenAIRE

    Goñi Elizalde, Sara; Guerrero Bustos, Ana María

    2006-01-01

    En este trabajo se discute la influencia del tipo de curado y de un aditivo reductor de la demanda de agua en la actividad hidráulica de un cemento belítico de cenizas volantes de alto contenido en cal denominado (CBCV-2-A). Este cemento ha sido sintetizado por una ruta húmeda hidrotermal con posterior calcinación, empleando ceniza volante de alto contenido en cal (ASTM tipo C) como materia prima. La actividad hidráulica se ha estudiado en la pasta de cemento, durante un periodo de 180 ...

  12. Interação genótipo x ambiente em genótipos de feijão-caupi semiprostrado via modelos mistos

    Directory of Open Access Journals (Sweden)

    Francisco Eduardo Torres

    2015-01-01

    Full Text Available A metodologia de modelos mistos (REML/BLUP tem sido empregada para estudar os efeitos da interação genótipo x ambiente (G x E em várias culturas, como: arroz, feijão, cana-de-açúcar, cajueiro e eucalipto, porém ainda não foi aplicada em feijão-caupi. Assim, o objetivo deste trabalho foi selecionar simultaneamente genótipos de feijão-caupi semiprostrado cultivados no Estado do Mato Grosso do Sul, via modelos mistos, que reúnam alta adaptabilidade, estabilidade e produtividade de grãos. Foram conduzidos quatro ensaios de valor de cultivo e uso com genótipos de genótipos de feijão-caupi nos anos de 2005 e 2006 em Aquidauana, Chapadão do Sul e Dourados. O delineamento experimental utilizado foi o de blocos completos casualizados, com 20 genótipos e 4 repetições. Os parâmetros genéticos foram estimados pela metodologia REML/BLUP, e a seleção baseou-se no método da média harmônica do desempenho relativo dos valores genéticos (MHPRVG, em três estratégias: seleção com base no valor genético predito, tendo-se considerado o desempenho médio dos genótipos em todos os ambientes (sem efeito de interação ou o desempenho em cada ambiente (com efeito da interação; e seleção simultânea quanto à produtividade de grãos, estabilidade e adaptabilidade. Os genótipos BRS Paraguaçu, MNC99-542F-5 e MNC99-508G-1 podem ser cultivados em vários ambientes, pois reúnem alta produtividade de grãos, adaptabilidade e estabilidade. A herdabilidade da média dos genótipos apresentou magnitude variando de moderada a alta, fato que indica excelentes possibilidades para a seleção, permitindo acurácia seletiva de 82%.

  13. Comparación de conectores de cortante tipo espigo con cabeza con tipo perno sobre tablero metálico

    OpenAIRE

    Guzmán Varón, Carlos Hernán

    2016-01-01

    La presente investigación tiene como propósito comparar la capacidad última de conectores de cortante tipo espigo con cabeza (stud) con los conectores de cortante tipo perno, en losa de concreto vaciado sobre tablero metálico, los cuales junto con la viga de acero conforman sección compuesta -- Dicha comparación se realizó a partir de los resultados obtenidos de las pruebas de corte directo, push out, realizadas a probetas -- Estas consistieron en dos placas de concreto vaciado sobre tablero ...

  14. Diabetes tipo 2 en niños: Serie de casos

    OpenAIRE

    Helard Manrique-Hurtado; Pedro Aro-Guardia; Miguel Pinto-Valdivia

    2015-01-01

    Objetivos: Describir las características clínicas y bioquímicas de un grupo de niños y adolescentes con diagnóstico reciente de diabetes tipo 2. Material y métodos: Estudio descriptivo, retrospectivo, tipo de serie de casos. Se definió caso al niño o adolescente con glucosa plasmática en ayunas mayor a 126 mg/dl, ausencia de antiGAD y péptido C mayor a 1,5 ng/dl. Se excluyeron a los pacientes con diagnóstico previo de diabetes mellitus tipo 1, diabetes tipo MODY o diabetes secundaria a uso de...

  15. Clases y tipos de predicados en la lengua Kogui

    Directory of Open Access Journals (Sweden)

    1994-01-01

    que les verbes de n’importe quelle valence, y compris les impersonnels, peuvent recevoir des marques différentes d’actance avec des fonctions différentes. Une autre classe de prédicats est celui que nous désignons comme “existentiel”. Le noyau est un verbe nominalisé avec des marques personnelles et temporelles il a un “présentateur” qui est un verbe d’existence fossilisé, porteur uniquement d’une marque modale fixe. Ce type de prédicat se différencie du prédicat verbal périphrastique car le présentateur n’est pas un verbe auxiliaire (il ne reçoit ni marques temporelles ni marques actancielles, il est extérieur à l’état de choses décrit. Enfin nous faisons une brève présentation des différentes classes modales d’énoncés selon la marque présente dans le prédicat verbal. El primer criterio que tenemos en cuenta para la clasificación del predicado kogui es la categoría gramatical del núcleo. Aquí, la primera oposición necesaria es: predicados de núcleos nominales, predicados de núcleos verbales. Estas dos clases de predicados, a su vez pueden subclasificarse en diferentes tipos, atendiendo a criterios morfológicos, semánticos, funcionales y estructurales. Hay varios tipos de predicado nominal a saber: 1. El constituido por un nombre o sintagma nominal que dice o predica algo de un sujeto expresado en un nominal. 2. Aquel cuyo núcleo es un verbo nominalizado, también con un sujeto expresado en un nominal. Dentro de esta clase de predicados, tenemos ejemplos sobre un único caso de verbo nominalizado con marca de actancia y aspecto, que puede ser núcleo del predicado y sujeto con las mismas marcas. 3. El constituido por un cualificador que también predica de un sujeto nominal, y que gramaticalmente comparte características morfológicas del nombre, por recibir marca de colectivizador, y del verbo, por tener una marca fija de actancia. El predicado verbal tiene como núcleo un verbo que puede estar en forma sintética, o

  16. Tipos de propiedad y comportamiento estratégico de la empresa

    OpenAIRE

    Nieto Sánchez, María Jesús

    2001-01-01

    Esta tesis tiene como principal objetivo profundizar en el entendimiento de los efectos de diferentes tipos de propietarios como factor determinante de los objetivos y de las decisiones empresariales en presencia de problemas informativos. La investigacion trata de explicar algunas de las consecuencias que tiene en el comportamiento estrategico de las empresas participadas, la existencia de distintos tipos de inversores estables, bien informados y con capacidad de control, como son los grupos...

  17. La victimología como ciencia : tipos de víctimas

    OpenAIRE

    Liñares Lobón, Pablo

    2013-01-01

    El tratamiento de los diversos tipos de víctimas ha sido objeto de estudio de la perspectiva psicológica desde los últimos años. En este sentido, es tan vital conocer bien los tipos de víctimas como las herramientas metodológicas que son utilizadas en los programas de intervención que aporten soluciones reales al problema

  18. Tourette Syndrome (TS): Treatments

    Science.gov (United States)

    ... providers, coaches, therapists, and other family members. Taking advantage of all the resources available will help guide ... Disease Control and Prevention Email Recommend Tweet YouTube Instagram Listen Watch RSS ABOUT About CDC Jobs Funding ...

  19. The TS-Tree

    DEFF Research Database (Denmark)

    Assent, Ira; Krieger, Ralph; Afschari, Farzad

    2008-01-01

    Continuous growth in sensor data and other temporal data increases the importance of retrieval and similarity search in time series data. Efficient time series query processing is crucial for interactive applications. Existing multidimensional indexes like the R-tree provide efficient querying fo...

  20. Resistência de genótipos de feijoeiro a Bemisia tabaci biótipo B Resistance of bean genotypes to Bemisia tabaci biotype B

    Directory of Open Access Journals (Sweden)

    Lucas Castro Torres

    2012-01-01

    Full Text Available O estudo de genótipos de feijoeiro resistentes à mosca-branca Bemisia tabaci (Genn. biótipo B (Hemiptera: Aleyrodidae é de grande importância devido aos danos ocasionados por essa praga à cultura. Neste trabalho, foram estudados a atratividade para adultos, a preferência para oviposição em testes com e sem chance de escolha, o ciclo ovo-adulto e o tipo e número de tricomas presentes nos folíolos. Os experimentos foram realizados em casa de vegetação avaliando-se, inicialmente, cem genótipos de feijoeiro. A resistência do tipo não-preferência para alimentação e/ou antibiose foi observada nos genótipos ARC-3, IAC-Alvorada e Canário 101, sendo a emergência de adultos fortemente influenciada pelos genótipos. Também se observou correlação negativa moderada entre o número de ovos e o número de tricomas glandulares, e correlação positiva muito forte entre o número de ovos e o número de tricomas tectores unciformes.The study of bean genotypes resistant to the whitefly Bemisia tabaci (Genn. B biotype (Hemiptera: Aleyrodidae has been of great importance due to the damage caused by this pest. In this research, bean genotypes were evaluated regarding attractiveness to whitefly adults, the preference for oviposition in free-choice and non choice tests, egg-to-adult development time and characterized for the presence, type and number of trichomes. The experiments were carried out under greenhouse conditions initially evaluating 100 bean genotypes. The non-preference type of resistance for feeding and/or antibiosis was observed in the genotypes ARC-3, IAC-Alvorada and Canário 101, and the emergence of adults was strongly influenced by the genotypes. It was also observed a moderate negative correlation between the number of eggs and the number of glandular trichomes, as well as a very strong positive correlation between the number of eggs and the number of unciform non-glandular trichomes.

  1. Genótipos de haptoglobina e hipertensão refratária em pacientes com diabete melito tipo 2

    Directory of Open Access Journals (Sweden)

    Vânia Pereira Albuquerque Wobeto

    2011-10-01

    Full Text Available FUNDAMENTO: Tem sido sugerido que o polimorfismo da haptoglobina pode influenciar na patogênese das complicações microvasculares e macrovasculares em pacientes diabéticos. OBJETIVO: O objetivo principal deste estudo transversal foi de realizar uma investigação da existência ou não de uma associação entre os genótipos de haptoglobina e a prevalência de eventos isquêmicos cardiovasculares (angina estável, angina instável e infarto agudo do miocárdio, hipertensão arterial sistêmica, hipertensão refratária, obesidade e dislipidemia em 120 pacientes com diabete melito tipo 2, seguidos no Hospital Universitário da Unicamp, em Campinas, Estado de São Paulo. MÉTODOS: A genotipagem da haptoglobina foi realizada por reações em cadeia da polimerase alelo-específicas. As frequências dos genótipos de haptoglobina foram comparadas com a presença/ausência de doença cardiovascular, hipertensão arterial sistêmica, hipertensão refratária, obesidade e dislipidemia; medições de pressão arterial sistólica e diastólica; glicemia, colesterol (total, lipoproteínas de alta densidade - HDL e lipoproteínas de baixa densidade - LDL e triglicerídeos; assim como níveis de creatinina sérica. RESULTADOS: Embora nenhuma associação entre o genótipo de haptoglobina e a presença de doença cardiovascular tenha sido identificada, encontramos um excesso significativo de pacientes com o genótipo Hp2-1 entre as pessoas com hipertensão refratária, que também apresentavam uma maior pressão arterial sistólica e diastólica e níveis de colesterol total e LDL. CONCLUSÃO: Nossos resultados sugerem que os pacientes com diabete melito tipo 2 com o genótipo Hp2-1 podem apresentar uma maior chance de desenvolver hipertensão refratária. Estudos adicionais em populações diabéticas são necessários para confirmar esses achados.

  2. Constraining |V(td)|/|V(ts)| Using Radiative Penguin B -> V(K*/rho/omega)gamma Decays

    International Nuclear Information System (INIS)

    Tan, Ping

    2006-01-01

    Exclusive radiative penguin B decays, B → (K* 0 /K* + )γ and B → (ρ/ω)γ, are flavor-changing neutral-current (FCNC) processes. Studies of these decays are of special interest in testing Standard Model (SM) predictions and searching for other beyond-the-SM FCNC interactions. Using 89 x 10 6 B(bar B) pairs from BABAR, we measure the branching fraction (Β), CP-asymmetry (Α), and isospin asymmetry (Δ 0- ) of B → (K* 0 /K* + )γ as follows: Β(B 0 → K* 0 γ) = 3.92 ± 0.20(stat.) ± 0.24(syst.); Β(B + → K* + γ) = 3.87 ± 0.28(stat.) ± 0.26(syst.); Α(B → K*γ) = 0.013 ± 0.36(stat.) ± 0.10(syst.); Δ 0- (B → K*γ) = 0.050 ± 0.045(stat.) ± 0.028(syst.) ± 0.024(R +/0 ). The 90% confidence intervals for the CP-asymmetry and the isospin-asymmetry in the B → K*γ decay are given as: -0.074 0- (B → K*γ) 6 B(bar B) pairs from BABAR. No evidence for these decays is found. We set the upper limits at 90% confidence level for these decays: Β(B 0 → ρ 0 γ) -6 , Β(B + → ρ + γ) -6 , Β(B 0 → ωγ) -6 , (bar Β)(B → (ρ/ω)γ) -6 . These results are in good agreement with the SM predictions. The branching fractions of these decays are then used to constrain the ratio |V td |/|V ts |

  3. Circulating strains of Brucella abortus in cattle in the province of Santo Domingo de los Tsáchilas - Ecuador.

    Directory of Open Access Journals (Sweden)

    Richar Ivan Rodríguez Hidalgo

    2015-03-01

    Full Text Available In Ecuador, the Province of Santo Domingo de los Tsáchilas represents the largest informal market of livestock due to its strategic position in the country; thus, given the high mobility of cattle in this region, the aim of this study was to determine the strain variation of Brucella sp.. Part of the study was the isolation, biotyping and genotyping of Brucella species isolated from milk and supra-mammary lymph nodes of sero-positive bovines. Protocols used for isolation, biotyping and genotyping of Brucella species were selective Farrell medium, biochemical assays and IS711-PCR, AMOS-PCR and HOOF-Prints techniques, respectively. In total, 656 animals from sero-positive dairy herds and from the slaughterhouse of the province were diagnosed by Rose Bengal and Wright’s Slow Agglutination test with EDTA. From these animals, 50 animals were found sero-positive for brucellosis. Twenty-five lymph nodes and 25 milk samples from each group of positive reactors were cultured and growth. Isolation was possible in 4 (16% and 9 (36%, respectively; and of these, 10 isolates were diagnosed as Brucella sp. All 4 isolates of lymphatic tissue corresponded to Brucella abortus biotype 1, confirmed as field strains by molecular analysis. Milk isolations, biochemically showed a more dispersed pattern in which B. abortus biotypes 1 and 4 were found; yet four samples gave a pattern similar to B. abortus biotype 2; however, only biotypes 1 and 4 were confirmed by molecular analysis. The concordance between biochemical and molecular diagnostic tests reached 76.9%.

  4. Adaptive fuzzy neural network control design via a T-S fuzzy model for a robot manipulator including actuator dynamics.

    Science.gov (United States)

    Wai, Rong-Jong; Yang, Zhi-Wei

    2008-10-01

    This paper focuses on the development of adaptive fuzzy neural network control (AFNNC), including indirect and direct frameworks for an n-link robot manipulator, to achieve high-precision position tracking. In general, it is difficult to adopt a model-based design to achieve this control objective due to the uncertainties in practical applications, such as friction forces, external disturbances, and parameter variations. In order to cope with this problem, an indirect AFNNC (IAFNNC) scheme and a direct AFNNC (DAFNNC) strategy are investigated without the requirement of prior system information. In these model-free control topologies, a continuous-time Takagi-Sugeno (T-S) dynamic fuzzy model with online learning ability is constructed to represent the system dynamics of an n-link robot manipulator. In the IAFNNC, an FNN estimator is designed to tune the nonlinear dynamic function vector in fuzzy local models, and then, the estimative vector is used to indirectly develop a stable IAFNNC law. In the DAFNNC, an FNN controller is directly designed to imitate a predetermined model-based stabilizing control law, and then, the stable control performance can be achieved by only using joint position information. All the IAFNNC and DAFNNC laws and the corresponding adaptive tuning algorithms for FNN weights are established in the sense of Lyapunov stability analyses to ensure the stable control performance. Numerical simulations and experimental results of a two-link robot manipulator actuated by dc servomotors are given to verify the effectiveness and robustness of the proposed methodologies. In addition, the superiority of the proposed control schemes is indicated in comparison with proportional-differential control, fuzzy-model-based control, T-S-type FNN control, and robust neural fuzzy network control systems.

  5. H∞ Filtering for Discrete Markov Jump Singular Systems with Mode-Dependent Time Delay Based on T-S Fuzzy Model

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    Cheng Gong

    2014-01-01

    Full Text Available This paper investigates the H∞ filtering problem of discrete singular Markov jump systems (SMJSs with mode-dependent time delay based on T-S fuzzy model. First, by Lyapunov-Krasovskii functional approach, a delay-dependent sufficient condition on H∞-disturbance attenuation is presented, in which both stability and prescribed H∞ performance are required to be achieved for the filtering-error systems. Then, based on the condition, the delay-dependent H∞ filter design scheme for SMJSs with mode-dependent time delay based on T-S fuzzy model is developed in term of linear matrix inequality (LMI. Finally, an example is given to illustrate the effectiveness of the result.

  6. Els aplecs «ts» i «dz» en valencià. Una anàlisi des de la teoria de l'optimitat

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    Jesús Jiménez

    2015-10-01

    Full Text Available This article intends to demonstrate that the final form of the clusters /ts/ and /dz/ in the Valencian dialect depends upon the behaviour of a series of universal principles referring to the syllabic structure. The author assumes that such restrictions are ranked on a language particular basis, according to the postulates of Optimality Theory (Prince & Smolensky 1993. Then, the outputs for the alveolar clusters will be the result of applying the constraint hierarchy to the set of possible candidates consistent with every input. The different results of the clusters /ts/ and /dz/ in Valencian, and this dialect' s divergences from other Catalan varieties are explained by the differences in the ranking of the principles which each variety presents.

  7. Use of neural network techniques to identify cosmic ray electrons and positrons during the 1993 balloon flight of the NMSU/Wizard-TS93 instrument

    Energy Technology Data Exchange (ETDEWEB)

    Bellotti, R.; Castellano, M. [Bari Univ. (Italy)]|[INFN, Bari (Italy); Candusso, M.; Casolino, M.; Morselli, A.; Picozza, P. [Rome Univ. `Tor Vergata` (Italy)]|[INFN, Rome (Italy); Aversa, F.; Boezio, M. [Trieste Univ. (Italy)]|[INFN, Trieste (Italy); Barbiellini, G. [Trieste Univ. (Italy)]|[INFN, Trieste (Italy); Basini, G. [INFN, Laboratori Nazionali di Frascati, Rome (Italy)

    1995-09-01

    The detectors used in the TS93 balloon flight produced a large volume of information for each cosmic ray trigger. Some of the data was visual in nature, other portions contained energy deposition and timing information. The data sets are amenable to conventional analysis techniques but there is no assurance that conventional techniques make full use of subtle correlations and relations amongst the detector responses. With the advent of neural network technologies, particularly adept at classification of complex phenomena, it would seem appropriate to explore the utility of neural network techniques to classify particles observed with the instruments. In this paper neural network based methodology for signal/background discrimination in a cosmic ray space experiment is discussed. Results are presented for electron and positron classification in the TS93 flight data set and will be compared to conventional analyses.

  8. Gemcitabine-Based Chemogene Therapy for Pancreatic Cancer Using Ad-dCK::UMK GDEPT and TS/RR siRNA Strategies

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    Soukaina Réjiba

    2009-07-01

    Full Text Available Gemcitabine is a first-line agent for advanced pancreatic cancer therapy. However, its efficacy is often limited by its poor intracellular metabolism and chemoresistance. To exert its antitumor activity, gemcitabine requires to be converted to its active triphosphate form. Thus, our aim was to improve gemcitabine activation using gene-directed enzyme prodrug therapy based on gemcitabine association with the deoxycytidine kinase::uridine monophosphate kinase fusion gene (dCK::UMK and small interference RNA directed against ribonucleotide reductase (RRM2 and thymidylate synthase (TS. In vitro, cytotoxicity was assessed by 3-[4,5-dimethylthiazol-2-yl]-3,5-diphenyl tetrazolium bromide and [3H]thymidine assays. Apoptosis-related gene expression and activity were analyzed by reverse transcription-polymerase chain reaction, Western blot, and ELISA. For in vivo studies, the treatment efficacy was evaluated on subcutaneous and orthotopic pancreatic tumor models. Our data indicated that cell exposure to gemcitabine induced a down-regulation of dCK expression and up-regulation of TS and RR expression in Panc1-resistant cells when compared with BxPc3- and HA-hpc2-sensitive cells. The combination of TS/RRM2 small interference RNA with Ad-dCK::UMK induced a 40-fold decrease of gemcitabine IC50 in Panc1 cells. This strong sensitization was associated to apoptosis induction with a remarkable increase in TRAIL expression and a diminution of gemcitabine-induced nuclear factor-κB activity. In vivo, the gemcitabine-based tritherapy strongly reduced tumor volumes and significantly prolonged mice survival. Moreover, we observed an obvious increase of apoptosis and decrease of cell proliferation in tumors receiving the tritherapy regimens. Together, these findings suggest that simultaneous TS/RRM2-gene silencing and dCK::UMK gene overexpression markedly improved gemcitabine's therapeutic activity. Clearly, this combined strategy warrants further investigation.

  9. Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors.

    Science.gov (United States)

    Heller, H Craig; Salehi, Ahmad; Chuluun, Bayarsaikhan; Das, Devsmita; Lin, Bill; Moghadam, Sarah; Garner, Craig C; Colas, Damien

    2014-12-01

    Down syndrome (DS) has an incidence of about 1/700 births, and is therefore the most common cause of cognitive and behavioral impairments in children. Recent studies on mouse models of DS indicate that a number of pharmacotherapies could be beneficial for restoring cognitive abilities in individuals with DS. Attention deficits that are present in DS account in part for learning and memory deficiencies yet have been scarcely studied in corresponding models. Investigations of this relevant group of behaviors is more difficult in mouse models because of the difficulty in homologizing mouse and human behaviors and because standard laboratory environments do not always elicit behaviors of interest. Here we characterize nest building as a goal-directed behavior that is seriously impaired in young Ts65Dn mice, a genetic model of DS. We believe this impairment may reflect in part attention deficits, and we investigate the physiological, genetic, and pharmacological factors influencing its expression. Nesting behavior in young Ts65Dn mice was severely impaired when the animals were placed in a novel environment. But this context-dependent impairment was transient and reversible. The genetic determinants of this deficiency are restricted to a ∼100 gene segment on the murine chromosome 16. Nest building behavior is a highly integrated phenotypic trait that relies in part on limbic circuitry and on the frontal cortex in relation to cognitive and attention processes. We show that both serotonin content and 5HT2a receptors are increased in the frontal cortex of Ts65Dn mice and that pharmacological blockage of 5HT2a receptors in Ts65Dn mice rescues their context dependent nest building impairment. We propose that the nest-building trait could represent a marker of attention related deficits in DS models and could be of value in designing pharmacotherapies for this specific aspect of DS. 5HT2a modulation may improve goal-directed behavior in DS. Copyright © 2014 Elsevier Inc

  10. Touchscreen learning deficits in Ube3a, Ts65Dn and Mecp2 mouse models of neurodevelopmental disorders with intellectual disabilities.

    Science.gov (United States)

    Leach, P T; Crawley, J N

    2017-12-20

    Mutant mouse models of neurodevelopmental disorders with intellectual disabilities provide useful translational research tools, especially in cases where robust cognitive deficits are reproducibly detected. However, motor, sensory and/or health issues consequent to the mutation may introduce artifacts that preclude testing in some standard cognitive assays. Touchscreen learning and memory tasks in small operant chambers have the potential to circumvent these confounds. Here we use touchscreen visual discrimination learning to evaluate performance in the maternally derived Ube3a mouse model of Angelman syndrome, the Ts65Dn trisomy mouse model of Down syndrome, and the Mecp2 Bird mouse model of Rett syndrome. Significant deficits in acquisition of a 2-choice visual discrimination task were detected in both Ube3a and Ts65Dn mice. Procedural control measures showed no genotype differences during pretraining phases or during acquisition. Mecp2 males did not survive long enough for touchscreen training, consistent with previous reports. Most Mecp2 females failed on pretraining criteria. Significant impairments on Morris water maze spatial learning were detected in both Ube3a and Ts65Dn, replicating previous findings. Abnormalities on rotarod in Ube3a, and on open field in Ts65Dn, replicating previous findings, may have contributed to the observed acquisition deficits and swim speed abnormalities during water maze performance. In contrast, these motor phenotypes do not appear to have affected touchscreen procedural abilities during pretraining or visual discrimination training. Our findings of slower touchscreen learning in 2 mouse models of neurodevelopmental disorders with intellectual disabilities indicate that operant tasks offer promising outcome measures for the preclinical discovery of effective pharmacological therapeutics. © 2017 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.

  11. Gene Electrotransfer of Plasmid with Tissue Specific Promoter Encoding shRNA against Endoglin Exerts Antitumor Efficacy against Murine TS/A Tumors by Vascular Targeted Effects.

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    Monika Stimac

    Full Text Available Vascular targeted therapies, targeting specific endothelial cell markers, are promising approaches for the treatment of cancer. One of the targets is endoglin, transforming growth factor-β (TGF-β co-receptor, which mediates proliferation, differentiation and migration of endothelial cells forming neovasculature. However, its specific, safe and long-lasting targeting remains the challenge. Therefore, in our study we evaluated the transfection efficacy, vascular targeted effects and therapeutic potential of the plasmid silencing endoglin with the tissue specific promoter, specific for endothelial cells marker endothelin-1 (ET (TS plasmid, in comparison to the plasmid with constitutive promoter (CON plasmid, in vitro and in vivo. Tissue specificity of TS plasmid was demonstrated in vitro on several cell lines, and its antiangiogenic efficacy was demonstrated by reducing tube formation of 2H11 endothelial cells. In vivo, on a murine mammary TS/A tumor model, we demonstrated good antitumor effect of gene electrotransfer (GET of either of both plasmids in treatment of smaller tumors still in avascular phase of growth, as well as on bigger tumors, already well vascularized. In support to the observations on predominantly vascular targeted effects of endoglin, histological analysis has demonstrated an increase in necrosis and a decrease in the number of blood vessels in therapeutic groups. A significant antitumor effect was observed in tumors in avascular and vascular phase of growth, possibly due to both, the antiangiogenic and the vascular disrupting effect. Furthermore, the study indicates on the potential use of TS plasmid in cancer gene therapy since the same efficacy as of CON plasmid was determined.

  12. Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndrome.

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    Matilda A Haas

    Full Text Available Down Syndrome (DS is a highly prevalent developmental disorder, affecting 1/700 births. Intellectual disability, which affects learning and memory, is present in all cases and is reflected by below average IQ. We sought to determine whether defective morphology and connectivity in neurons of the cerebral cortex may underlie the cognitive deficits that have been described in two mouse models of DS, the Tc1 and Ts1Rhr mouse lines. We utilised in utero electroporation to label a cohort of future upper layer projection neurons in the cerebral cortex of developing mouse embryos with GFP, and then examined neuronal positioning and morphology in early adulthood, which revealed no alterations in cortical layer position or morphology in either Tc1 or Ts1Rhr mouse cortex. The number of dendrites, as well as dendrite length and branching was normal in both DS models, compared with wildtype controls. The sites of projection neuron synaptic inputs, dendritic spines, were analysed in Tc1 and Ts1Rhr cortex at three weeks and three months after birth, and significant changes in spine morphology were observed in both mouse lines. Ts1Rhr mice had significantly fewer thin spines at three weeks of age. At three months of age Tc1 mice had significantly fewer mushroom spines--the morphology associated with established synaptic inputs and learning and memory. The decrease in mushroom spines was accompanied by a significant increase in the number of stubby spines. This data suggests that dendritic spine abnormalities may be a more important contributor to cognitive deficits in DS models, rather than overall neuronal architecture defects.

  13. A expansão do tratamento supervisionado (TS para o controle da tuberculose na Paraíba (1999/2005

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    Gianne de Oliveira Rodrigues

    2008-09-01

    Full Text Available O tratamento supervisionado (TS é um dos pilares da Estratégia DOTS (Directly Observed Treatment Short-course e sua adoção vem sendo recomendada, para o controle da tuberculose (TB. Neste estudo objetivou-se analisar as potencialidades e fragilidades no processo de expansão do Tratamento Supervisionado (TS nos seis municípios considerados prioritários para o controle da TB na Paraíba-PB/Brasil. Pesquisa de natureza qualitativa, que utilizou a entrevista semi-estruturada com 21 profissionais envolvidos na implantação e expansão do DOTS nos seis municípios. Os dados foram analisados pela técnica de análise de conteúdo, modalidade temática. Como potencialidades foram identificadas: apoio dos gestores no processo de descentralização do TS para as Unidades de Saúde da Família (USF; compromisso dos profissionais e boa comunicação entre USF e referências. Dentre as fragilidades relatadas observa-se a falta de apoio dos gestores para garantir infra-estrutura e estímulo financeiro para o profissional; falta de qualificação profissional; alta rotatividade dos profissionais e centralização da distribuição de medicamento. Apesar dos esforços para implantação do TS, reconhece-se que sua ampliação esta condicionada a capacidade gerencial e ao compromisso político dos gestores.

  14. Measurement of DPD and TS transcripts aimed to predict clinical benefit from fluoropyrimidines: confirmation of the trend in Russian colorectal cancer series and caution regarding the gene referees.

    Science.gov (United States)

    Iyevleva, Aglaya G; Buslov, Konstantin G; Togo, Alexandr V; Matsko, Dmitry E; Filimonenko, Vasily P; Moiseyenko, Vladimir M; Imyanitov, Evgeny N

    2007-06-01

    Measurement of intratumoral expression of dihydropyrimidine dehydrogenase (DPD) and thymidylate synthase (TS) may have some value in predicting the response to fluoropyrimidine-containing therapy. We attempted to validate this association in a series of Russian metastatic colorectal cancer cases. While replicating already published protocols, we unexpectedly found that the use of commonly utilized gene referees, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and beta-actin, may lead to artifacts due to pseudogene-driven amplification from the genomic DNA template. We have developed a real-time PCR protocol which amplifies short PCR fragments, thus allowing efficient analysis of archival formalin-fixed paraffin-embedded tumor samples, and relies on succinate dehydrogenase (SDHA) as a gene referee, therefore avoiding amplification from genomic DNA. Low content of DPD transcripts was observed in 13/20 (65%) patients with disease control (tumor response or disease stabilization) as compared to only 3/9 (33%) subjects with progressive disease (p = 0.11). Despite the low number of patients, this association reached the level of statistical significance when similar analysis was done for TS expression (11/20 (55%) vs. 1/9 (11%); p = 0.03). Our data confirm that low DPD and TS expressors have higher chances of success of fluoropyrimidine-containing regimens.

  15. Rapid, Simple and Cost-Effective Molecular Method to Differentiate the Temperature Sensitive (ts+ MS-H Vaccine Strain and Wild-Type Mycoplasma synoviae Isolates.

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    Zsuzsa Kreizinger

    Full Text Available Mycoplasma synoviae infection in chickens and turkeys can cause respiratory disease, infectious synovitis and eggshell apex abnormality; thus it is an economically important pathogen. Control of M. synoviae infection comprises eradication, medication or vaccination. The differentiation of the temperature sensitive (ts+ MS-H vaccine strain from field isolates is crucial during vaccination programs. Melt-curve and agarose gel based mismatch amplification mutation assays (MAMA are provided in the present study to distinguish between the ts+ MS-H vaccine strain, its non-temperature sensitive re-isolates and wild-type M. synoviae isolates based on the single nucleotide polymorphisms at nt367 and nt629 of the obg gene. The two melt-MAMAs and the two agarose-MAMAs clearly distinguish the ts+ MS-H vaccine strain genotype from its non-temperature sensitive re-isolate genotype and wild-type M. synoviae isolate genotype, and no cross-reactions with other Mycoplasma species infecting birds occur. The sensitivity of the melt-MAMAs and agarose-MAMAs was 103 and 104 copy numbers, respectively. The assays can be performed directly on clinical samples and they can be run simultaneously at the same annealing temperature. The assays can be performed in laboratories with limited facilities, using basic real-time PCR machine or conventional thermocycler coupled with agarose gel electrophoresis. The advantages of the described assays compared with previously used methods are simplicity, sufficient sensitivity, time and cost effectiveness and specificity.

  16. Rheological online determination of the organic dry substance concentration of sewage sludge; Rheologische online Bestimmung des oTS-Gehalts von Klaerschlamm

    Energy Technology Data Exchange (ETDEWEB)

    Schmitz, P.; Boehm, A.; Fessler, J.; Liebelt, U. [BASF AG, Ludwigshafen am Rhein (Germany); Traegner, U. [Fachhochschule fuer Technik, Mannheim (Germany)

    1999-07-01

    In order to adjust the filter cake to a certain calorific value and to enhance the dehydratability of sludge, ash, carbon and flocculation agents are added to the latter prior to filtration. Dosage of the additives depends on the sludge's content of organic solids, determined in the form of the so-called organic dry substance concentration. In bench-scale and technical-scale experiments on the rheological properties of sewage sludge, a correlation between organic dry substance concentration and rheological properties, especially the liquid limit of sewage sludge, was established. This knowledge was used to develop a measuring technique for online determination of organic dry substance concentration by means of rheology. (orig.) [German] Zur Einstellung eines bestimmten Heizwertes des Filterkuchens und zur Verbesserung der Entwaesserbarkeit werden dem Schlamm vor der Filtration Asche, Kohle und Flockungsmittel zugegeben. Die Dosierung der Zuschlagsstoffe erfolgt in Abhaengigkeit vom Gehalt des Schlamms an organischem Feststoff, bestimmt in Form der sog. oTS-Konzentration. In Labor- und Betriebsversuchen zum rheologischen Verhalten von Klaerschlamm konnte eine Korrelation zwischen der oTS-Konzentration und den Fliesseigenschaften, insbesondere der Fliessgrenze von Klaerschlamm ermittelt werden. Diese Erkenntnis wurde in ein Messverfahren zur online-Bestimmung der oTS-Konzentration mittels Rheologie umgesetzt. (orig.)

  17. Percepção do idoso dos comportamentos afetivos expressos pela equipe de enfermagem Percepción del anciano frente a los comportamientos afectivos expresados por el equipo de enfermería Perception of the elderly in the view of affective behaviors expressed by the nursing team

    Directory of Open Access Journals (Sweden)

    Teresa Cristina Prochet

    2011-12-01

    Full Text Available Objetivo:Identificar a percepção do comportamento da afetividade, pelo idoso hospitalizado, do cuidado recebido pela Equipe de Enfermagem. Material e Método: Estudo quantitativo, transversal e de campo desenvolvido com 28 idosos. Utilizou-se instrumento composto por 21 tipos de comportamento verbais e não verbais. Resultados: Os resultados positivos dos comportamentos verbais incluíram as ações de conversar (57,2%, orientar (60,7%, respeitar (50%, proporcionar segurança (44,6% e demonstrar honestidade (96,4%. Os positivos da dimensão não verbal reuniram aspectos relacionados ao respeito (63,4%, tocar (46,4%, ouvir/escutar (23,2% e olhar como expressão positiva (71,4%. Conclusão: A maioria dos idosos percebeu como positiva a afetividade do cuidado recebido pela Equipe de Enfermagem no que se refere à dimensão verbal, sendo o comportamento mais evidente a demonstração da sinceridade. As atitudes não verbais de ser ouvido/escutado e tocado com delicadeza assumiram avaliação negativa. A afetividade nas ações de enfermagem são percebidos pelo idoso, e estes interferem na avaliação da qualidade assistencial.Objetivo: Identificar la percepción de los comportamientos afectivos, por parte del anciano hospitalizado, y del cuidado recibido por los profesionales de enfermería. Metodología: Estudio cuantitativo, transversal y de campo desarrollado con 28 ancianos. Se utilizó un instrumento compuesto por 21 tipos de comportamientos verbales y no verbales. Resultados: Los resultados positivos de los comportamientos verbales incluyeron las acciones de conversar (57,2%, orientar (60,7%, respetar (50%, proporcionar seguridad (44,6% y demostrar honestidad (96,4%. Los resultados positivos de la dimensión no verbal reunieron aspectos relacionados al respeto (63,4%, tocar (46,4%, oír/escuchar (23,2% y el miramiento como expresión positiva (71,4%. Conclusión: La mayoría de los ancianos percibió como positiva la afectividad del cuidado

  18. Diabetes tipo 2 en niños: Serie de casos

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    Helard Manrique-Hurtado

    2015-01-01

    Full Text Available Objetivos: Describir las características clínicas y bioquímicas de un grupo de niños y adolescentes con diagnóstico reciente de diabetes tipo 2. Material y métodos: Estudio descriptivo, retrospectivo, tipo de serie de casos. Se definió caso al niño o adolescente con glucosa plasmática en ayunas mayor a 126 mg/dl, ausencia de antiGAD y péptido C mayor a 1,5 ng/dl. Se excluyeron a los pacientes con diagnóstico previo de diabetes mellitus tipo 1, diabetes tipo MODY o diabetes secundaria a uso de fármacos. Resultados: La edad media fue 14,3 años, 59% fueron mujeres y 43% tenía por lo menos un padre con diabetes tipo 2. Al momento del diagnóstico, el índice de masa corporal fue 32,8 kg/m2, 85% tenía acantosis nigricans y 68% estaba en estadio Tanner IV y V. El tratamiento inicial incluyó el uso de hipoglicemiantes orales en 75% de los casos, siendo más frecuente el uso de metformina (64,3%. Solamente el 41% de los pacientes recibía algún tipo de insulina. Conclusiones: Los niños y adolescentes con diabetes tipo 2, tienen una frecuencia aumentada de obesidad/sobrepeso, acantosis nigricans y antecedente familiar de DM2. En general, tienen mal control metabólico y reciben metformina como tratamiento inicial.

  19. Pre- and post-natal melatonin administration partially regulates brain oxidative stress but does not improve cognitive or histological alterations in the Ts65Dn mouse model of Down syndrome.

    Science.gov (United States)

    Corrales, Andrea; Parisotto, Eduardo B; Vidal, Verónica; García-Cerro, Susana; Lantigua, Sara; Diego, Marian; Wilhem Filho, Danilo; Sanchez-Barceló, Emilio J; Martínez-Cué, Carmen; Rueda, Noemí

    2017-09-15

    Melatonin administered during adulthood induces beneficial effects on cognition and neuroprotection in the Ts65Dn (TS) mouse model of Down syndrome. Here, we investigated the effects of pre- and post-natal melatonin treatment on behavioral and cognitive abnormalities and on several neuromorphological alterations (hypocellularity, neurogenesis impairment and increased oxidative stress) that appear during the early developmental stages in TS mice. Pregnant TS females were orally treated with melatonin or vehicle from the time of conception until the weaning of the offspring, and the pups continued to receive the treatment from weaning until the age of 5 months. Melatonin administered during the pre- and post-natal periods did not improve the cognitive impairment of TS mice as measured by the Morris Water maze or fear conditioning tests. Histological alterations, such as decreased proliferation (Ki67+ cells) and hippocampal hypocellularity (DAPI+ cells), which are typical in TS mice, were not prevented by melatonin. However, melatonin partially regulated brain oxidative stress by modulating the activity of the primary antioxidant enzymes (superoxide dismutase in the cortex and catalase in the cortex and hippocampus) and slightly decreasing the levels of lipid peroxidation in the hippocampus of TS mice. These results show the inability of melatonin to prevent cognitive impairment in TS mice when it is administered at pre- and post-natal stages. Additionally, our findings suggest that to induce pro-cognitive effects in TS mice during the early stages of development, in addition to attenuating oxidative stress, therapies should aim to improve other altered processes, such as hippocampal neurogenesis and/or hypocellularity. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Biochemical characterization of the triticale TsPAP1, a new type of plant prolyl aminopeptidase, and its impact on proline content and flowering time in transgenic Arabidopsis plants.

    Science.gov (United States)

    Zdunek-Zastocka, Edyta; Grabowska, Agnieszka; Branicki, Tomasz; Michniewska, Beata

    2017-07-01

    Proline aminopeptidase (PAP, EC 3.4.11.5) is the only enzyme that effectively releases proline from the N-termini of peptides. The amino acid sequence of the PAP from Triticosecale, TsPAP1, comprises conserved regions, characteristic of the monomeric forms of PAP found in bacteria but not yet identified in plants. Therefore, we aimed to obtain and biochemically characterize the TsPAP1 protein. The recombinant TsPAP1 protein was received through heterologous expression of the TsPAP1 coding sequence in a bacterial expression system and purified with affinity chromatography. Gel filtration chromatography and SDS electrophoresis revealed that TsPAP1 is a monomer with a molecular mass of 37.5 kDa. TsPAP1 prefers substrates with proline at the N-terminus but is also capable of hydrolyzing β-naphthylamides of hydroxyproline and alanine. Among the peptides tested, the most preferred were di- and tripeptides, especially those with glycine in the Y position. The use of diagnostic inhibitors indicated that TsPAP1 is a serine peptidase; however, further characterization revealed that the SH residues are also important for maintaining its activity. To examine the role of TsPAP1 under physiological conditions, we developed transgenic Arabidopsis plants overexpressing TsPAP1. Compared with wild-type plants, the transgenic lines accumulated more proline, flowered an average of 3.5 days earlier, and developed more siliques than did untransformed controls. Our paper is the first to describe the biochemical properties of a novel monomeric plant PAP and contributes to the functional characterization of PAP proteins in plants. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  1. Les coûts du diabète sur 10 ans au Canada : intégration des coûts en soins de santé imputables au diabète à un modèle de prédiction de son incidence

    Directory of Open Access Journals (Sweden)

    Anja Bilandzic

    2017-01-01

    Full Text Available Introduction : Notre objectif était d’estimer les coûts de santé directs liés au traitement du diabète au Canada sur 10 ans, à l’aide de données de sondages nationaux et d’un outil de prévision du risque de diabète, ainsi que les coûts par personne. Méthodologie : Nous avons utilisé le Diabetes Population Risk Tool pour estimer le nombre de nouveaux cas de diabète chez les personnes âgées de 20 ans et plus sur 10 ans (jusqu'en 2022 à l’aide des données de 2011 et de 2012 de l’Enquête sur la santé dans les collectivités canadiennes. Nous avons évalué les coûts liés au diabète à partir d’une étude de cohorte faisant appel à l’appariement par score de propension, en utilisant la base de données sur le diabète de l’Ontario ainsi que d’autres données administratives. Nous avons calculé les coûts totaux en utilisant les coûts associés aux nouveaux cas, en tenant compte du sexe, de l’année du diagnostic et des taux de mortalité annuels dus à la maladie. Résultats : D'après nos calculs, le risque de développer le diabète sur 10 ans s’élevait pour la population canadienne en 2011-2012 à 9,98 %, soit 2,16 millions de nouveaux cas. Les coûts totaux en soins de santé imputables au diabète pendant cette période sont de 15,36 milliards (7,55 milliards pour les femmes et 7,81 milliards pour les hommes. Ce sont les hospitalisations de courte durée qui constituent la majeure partie de ces coûts (43,2 %. Des interventions menées au sein de la population entraînant une perte de poids de 5 % au sein de la population permettraient de réduire les coûts des soins de santé de 2,03 milliards de dollars. Une réduction du risque de 30 % obtenue grâce à des interventions auprès des personnes à plus haut risque de développer le diabète (c.-à-d. les 10 % au sommet du groupe à risque le plus élevé entraînerait des économies de l’ordrede 1,48 million de dollars. Conclusion : D'ici 2022

  2. Constraining |V(td)|/|V(ts)| Using Radiative Penguin B -> V(K*/rho/omega)gamma Decays

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Ping; /Wisconsin U., Madison

    2006-03-08

    Exclusive radiative penguin B decays, B {yields} (K*{sup 0}/K*{sup +}) and B {yields} ({rho}/{omega}){gamma}, are flavor-changing neutral-current (FCNC) processes. Studies of these decays are of special interest in testing Standard Model (SM) predictions and searching for other beyond-the-SM FCNC interactions. Using 89 x 10{sup 6} B{bar B} pairs from BABAR, we measure the branching fraction ({Beta}), CP-asymmetry ({Alpha}), and isospin asymmetry ({Delta}{sub 0-}) of B {yields} (K*{sup 0}/K*{sup +}){gamma} as follows: {Beta}(B{sup 0} {yields} K*{sup 0}{gamma}) = 3.92 {+-} 0.20(stat.) {+-} 0.24(syst.); {Beta}(B{sup +} {yields} K*{sup +}{gamma}) = 3.87 {+-} 0.28(stat.) {+-} 0.26(syst.); {Alpha}(B {yields} K*{gamma}) = -0.013 {+-} 0.36(stat.) {+-} 0.10(syst.); {Delta}{sub 0-}(B {yields} K*{gamma}) = 0.050 {+-} 0.045(stat.) {+-} 0.028(syst.) {+-} 0.024(R{sup +/0}). The 90% confidence intervals for the CP-asymmetry and the isospin-asymmetry in the B {yields} K*{gamma} decay are given as: -0.074 < {Alpha}(B {yields} K*{gamma}) < 0.049, -0.046 < {Delta}{sub 0-} (B {yields} K*{gamma}) < 0.146. We also search for B {yields} ({rho}/{omega}){gamma} decays using 211 x 10{sup 6} B{bar B} pairs from BABAR. No evidence for these decays is found. We set the upper limits at 90% confidence level for these decays: {Beta}(B{sup 0} {yields} {rho}{sup 0}{gamma}) < 0.4 x 10{sup -6}; {Beta}(B{sup +}{yields} {rho}{sup =}{gamma}) < 1.8 x 10{sup -6}; {Beta}(B{sup 0} {yields} {omega}{gamma}) < 1.0 x 10{sup -6}; {bar {Beta}}(B {yields} ({rho}/{omega}){gamma}) < 1.2 x 10{sup -6}. These results are in good agreement with the SM predictions. The branching fractions of these decays are then used to constrain the ratio |V{sub td}|/|V{sub ts}|.

  3. Autoinmunidad y receptores tipo Toll = Autoimmunity and toll-like receptors

    Directory of Open Access Journals (Sweden)

    Ossa Giraldo, Ana Claudia

    2012-07-01

    Full Text Available La respuesta inmune innata está conformada por un conjunto de mecanismos que permiten reconocer los componentes propios del organismo y diferenciarlos de los microorganismos invasores para generar una primera línea de defensa. Este reconocimiento está mediado por diferentes receptores presentes en la superficie y en el interior de células inmunes y no inmunes; entre ellos se encuentran los siguientes: receptores tipo Toll (RTT, receptores de lectinas tipo C, receptores tipo GIR (genes inducibles por ácido retinoico y receptores tipo Nod y NALP, que reconocen patrones moleculares asociados a microorganismos (PMAM. Gracias a esta capacidad de discriminación, adquirida evolutivamente por la inmunidad innata, se ha aceptado tradicionalmente que los procesos autoinmunes no están relacionados con esta sino con la inmunidad adquirida. Sin embargo, varios estudios han demostrado que esa teoría no es totalmente cierta y que algunos mecanismos efectores de la inmunidad innata participan en la generación de las enfermedades autoinmunes o en la potenciación de su fisiopatología. En esta revisión se estudia la contribución de la inmunidad innata a la autoinmunidad con énfasis en el papel de los receptores tipo Toll.

  4. A New Method to Define the VI-Ts Diagram Using Subpixel Vegetation and Soil Information: A Case Study over a Semiarid Agricultural Region in the North China Plain

    Directory of Open Access Journals (Sweden)

    Masataka Watanabe

    2008-10-01

    Full Text Available The VI-Ts diagram determined by the scatter points of the vegetation index (VI and surface temperature (Ts has been widely applied in land surface studies. In the VI-Ts diagram, dry point is defined as a pixel with maximum Ts and minimum VI, while wet point is defined as a pixel with minimum Ts and maximum VI. If both dry and wet points can be obtained simultaneously, a triangular VI-Ts diagram can be readily defined. However, traditional methods cannot define an ideal VI-Ts diagram if there are no full ranges of land surface moisture and VI, such as during rainy season or in a period with a narrow VI range. In this study, a new method was proposed to define the VI-Ts diagram based on the subpixel vegetation and soil information, which was independent of the full ranges of land surface moisture and VI. In this method, a simple approach was firstly proposed to decompose Ts of a given pixel into two components, the surface temperatures of soil (Tsoil and vegetation (Tveg, by means of Ts and VI information of neighboring pixels. The minimum Tveg and maximum Tsoil were then used to determine the wet and dry points respectively within a given sampling window. This method was tested over a 30 km × 30 km semiarid agricultural area in the North China Plain through 2003 using Advanced Spaceborne Thermal Emission Reflection Radiometer (ASTER and MODerate-resolution Imaging Spectroradiometer (MODIS data. The wet and dry points obtained from our proposed method and from a traditional method were compared with those obtained from ground data within the sampling window with the 30 km × 30 km size. Results show that Tsoil and Tveg can be obtained with acceptable accuracies, and that our proposed method can define reasonable VI-Ts diagrams over a semiarid agricultural region throughout the whole year, even for both cases of rainy season and narrow range of VI.

  5. A New Method to Define the VI-Ts Diagram Using Subpixel Vegetation and Soil Information: A Case Study over a Semiarid Agricultural Region in the North China Plain.

    Science.gov (United States)

    Sun, Zhigang; Wang, Qinxue; Matsushita, Bunkei; Fukushima, Takehiko; Ouyang, Zhu; Watanabe, Masataka

    2008-10-07

    The VI-Ts diagram determined by the scatter points of the vegetation index (VI) and surface temperature (Ts) has been widely applied in land surface studies. In the VI-Ts diagram, dry point is defined as a pixel with maximum Ts and minimum VI, while wet point is defined as a pixel with minimum Ts and maximum VI. If both dry and wet points can be obtained simultaneously, a triangular VI-Ts diagram can be readily defined. However, traditional methods cannot define an ideal VI-Ts diagram if there are no full ranges of land surface moisture and VI, such as during rainy season or in a period with a narrow VI range. In this study, a new method was proposed to define the VI-Ts diagram based on the subpixel vegetation and soil information, which was independent of the full ranges of land surface moisture and VI. In this method, a simple approach was firstly proposed to decompose Ts of a given pixel into two components, the surface temperatures of soil (T soil ) and vegetation (T veg ), by means of Ts and VI information of neighboring pixels. The minimum T veg and maximum T soil were then used to determine the wet and dry points respectively within a given sampling window. This method was tested over a 30 km × 30 km semiarid agricultural area in the North China Plain through 2003 using Advanced Spaceborne Thermal Emission Reflection Radiometer (ASTER) and MODerate-resolution Imaging Spectroradiometer (MODIS) data. The wet and dry points obtained from our proposed method and from a traditional method were compared with those obtained from ground data within the sampling window with the 30 km × 30 km size. Results show that T soil and T veg can be obtained with acceptable accuracies, and that our proposed method can define reasonable VI-Ts diagrams over a semiarid agricultural region throughout the whole year, even for both cases of rainy season and narrow range of VI.

  6. Biometria e armazenamento de sementes de genótipos de cacaueiro

    Directory of Open Access Journals (Sweden)

    Lucimara Ribeiro Venial

    2017-03-01

    Full Text Available Genótipos de Theobroma cacao L. devem ser melhor estudados, para se identificar aqueles que produzem sementes mais desenvolvidas e viáveis após o armazenamento. Objetivou-se com este trabalho estudar a biometria e dois tempos de armazenamento de sementes de genótipos de cacaueiro. A biometria foi avaliada em oito genótipos de cacaueiro (tratamentos. Foram instalados testes de germinação em delineamento inteiramente ao acaso, no esquema fatorial 8 x 2 (genótipos: CCN51, PH16, CEPEC2002, Ipiranga, SJ02, PS1319, TSH1188 e Comum x dois períodos de armazenamento: 0 e dois dias. O genótipo TSH1188 apresentou maior comprimento, relação comprimento/largura, espessura e massa de 100 sementes. A absorção de água das sementes recém-colhidas dos genótipos é lenta, justificada pelos altos teores de água, o que não caracteriza padrão-trifásico. Os teores de água reduziram em média 2,3 vezes nas sementes armazenadas em relação às recém-colhidas. A germinação das sementes recém-colhidas dos genótipos foi de 100%. Após o armazenamento, as sementes do PS1319 apresentaram a menor redução da germinação (39%, enquanto as dos PH16, CEPEC2002 e SJ02 reduziram 96%. A velocidade de germinação foi maior e o tempo médio menor que dois dias nas sementes recém-colhidas do PS1319, indicando serem mais tolerante à dessecação. Sugere-se o uso dos genótipos TSH1188 e PS1319 em programas de melhoramento genético.

  7. Tipologias e Arquétipos: a Psicologia Profunda como base para uma hermenêutica

    OpenAIRE

    Jactania Marques Muller; Patricia de Sá Freire

    2015-01-01

    http://dx.doi.org/10.5007/1807-1384.2015v12n1p382FERNANDES, Ermelinda Ganem; FIALHO, Francisco Antônio Pereira. Tipologias e arquétipos: a Psicologia Profunda como base para uma hermenêutica - Coleção Jung sai pra rua. v. 1. Florianópolis: Insular, 2014. 264 p. FERNANDES, Ermelinda Ganem; FIALHO, Francisco Antônio Pereira. Tipologias e arquétipos: a Psicologia Profunda como base para uma hermenêutica - Coleção Jung sai pra rua. v. 1. Florianópolis: Insular, 2014. 264 p. FERNANDES, Ermel...

  8. Procedimentos para o projeto de superfícies de controle do tipo fowler flap.

    OpenAIRE

    Gustavo Limongi Araújo

    2003-01-01

    Superfícies de controle do tipo flape são utilizadas nos bordos de ataque e de fuga durante algumas fases do vôo como decolagem, pouso e aproximação para aumento de sustentação da aeronave em baixa velocidade. Este trabalho envolve o estudo do mecanismo de atuação de superfícies de controle do tipo flape para avaliar a influência da presença de folgas, tolerâncias dos componentes, desalinhamento dos trilhos e rigidez do painel, no desempenho do sistema durante seu funcionamento, ainda na fase...

  9. Comportamentos de risco para transtornos alimentares em adolescentes e adultos portadores de diabetes tipo 1

    OpenAIRE

    Milena Gonçalves Lima Cardoso

    2009-01-01

    Introdução - Pacientes portadores de diabetes tipo 1 que manifestam comportamentos de risco para transtornos alimentares (TA) possuem grandes chances de complicações microvasculares e macrovasculares e maiores taxas de mortalidade. Objetivo Avaliar a freqüência de comportamento de risco para TA em adolescentes e adultos portadores de diabetes tipo 1 bem como sua relação com variáveis socioeconômicas, nutricionais, relacionadas ao diabetes e satisfação corporal. Metodologia: Foram aplicados: ...

  10. A rede social e os tipos de apoio recebidos por idosos institucionalizados

    OpenAIRE

    Rodrigues,Adriana Guimarães; Silva,Ailton Amélio da

    2013-01-01

    Estudo descritivo que teve como objetivo identificar a composição da rede de apoio social de idosos institucionalizados, bem como os tipos e as quantidades de apoios recebidos por eles. O apoio social tem função importante no enfretamento das perdas e limitações da velhice. Participaram 30 idosos institucionalizados com média de idade de 74 anos. Foram aplicadas entrevistas e a escala de apoio social para identificar a composição da rede social e tipos de apoio social que os idosos recebiam. ...

  11. Relaciones entre estilos de personalidad y tipos de consumo de alcohol

    OpenAIRE

    Jairo Andrés Castañeda Arcila; Liliana Chaves Castaño

    2013-01-01

    Objetivo. Esta investigación buscó identificar, en la población adulta del municipio de El Retiro (Antioquia), los tipos de consumo de alcohol, así como su relación con estilos de personalidad. Método. Se realizó un estudio transversal, descriptivo y correlacional. Se aplicaron dos instrumentos, Millon Inventory of Personality (MIPS) y Alcohol Use Disorder Identification Test (Audit) en una muestra de 61 participantes, de los cuales 33 fueron hombres y 28 mujeres. Resultados. El tipo de consu...

  12. No todas las rondas son comites de autodefensa y viceversa. Los tipos de rondas campesinas

    OpenAIRE

    korsbaek, Leif

    2014-01-01

    En el prescntc texto se Presen tan los rasgos generales de la insri rución con ocida C(.1mo la ronda campesina -su origen, su historia, su distribución y sus caracterisricas-e- en términos gcncrale», Pero se insiste en 1;1 importancia de distinguir entre los diversos tipos de rondas campesinas, pues tienen dinámicas sociales y culturales muy diferentes. Se preselllóln cuatro tipos de rondas campesinas: las rondas campesinas originales que nacieron en regiones del norte del Perú donde se había...

  13. Medidas faciais antropométricas de adultos segundo tipo facial e sexo

    OpenAIRE

    Ramires,Rossana Ribeiro; Ferreira,Léslie Piccolotto; Marchesan,Irene Queiroz; Cattoni,Débora Martins; Andrada e Silva,Marta Assumpção de

    2011-01-01

    OBJETIVO: descrever medidas antropométricas faciais de adultos, segundo tipo facial e sexo. MÉTODOS: participaram 105 adultos leucodermas, 34 (32,4%) homens e 71 (67,6%) mulheres, com idades entre 20 e 40 anos, de uma clínica particular de ortodontia de Belo Horizonte, Minas Gerais. Foram comparados os achados da análise cefalométrica para determinação do tipo de face com sete medidas antropométricas faciais diretas: altura facial anterior- násio ao mentoniano; distância bizigomática- zigomát...

  14. Diabetes tipo 2 y depresión en guadalajara, méxico. 2005

    OpenAIRE

    Colunga-Rodríguez, Cecilia; García de Alba, Javier E.; Salazar-Estrada, José G.; Ángel-González, Mario

    2008-01-01

    Objetivo Determinar la prevalencia de depresión y comparar indicadoressociodemográficos, metabólicos y clínicos, en personas con diabetes tipo 2deprimidas y no deprimidas.Material y Métodos Se realizó un estudio transversal comparativo en una muestrade 450 personas con diabetes tipo 2, mayores de 30 años, con más de un año dediagnóstico y sin determinación de psicopatología. Aplicamos escala de Zungmodificada y encuesta sociodemográfica, evaluamos Hemoglobina glucosilada,índice de masa corpor...

  15. Percepción de la insulinoterapia en pacientes con diabetes mellitus tipo 2 descontrolada

    OpenAIRE

    Leyva Jiménez, Rafael; Hernández Zambrano, Gustavo; Ibarra Maldonado, Silvia; Ibarra Ramírez, Carlos Tomás

    2016-01-01

    Objetivo: Conocer la percepción de la insulinoterapia en los pacientes con diabetes mellitus tipo 2 descontrolada tratados con hipoglucemiantes orales o con insulina. Diseño: Transversal comparativo prospectivo. Emplazamiento: Unidad de Medicina Familiar número 53 de la Delegación Guanajuato del Instituto Mexicano del Seguro Social. Participantes: Pacientes de 40 a 80 años afectos de diabetes tipo 2, descontrolados, en tratamiento con insulina o hipoglucemiantes orales. Mediciones...

  16. Cefaléia na malformação de chiari tipo 1

    OpenAIRE

    MARTINS, Hugo André de Lima

    2006-01-01

    O objetivo principal deste estudo foi caracterizar e compreender de forma clara e direta a cefaléia associada à malformação de Chiari tipo 1 (MC-1). Entrevistamos 19 pacientes com MC-1, dentre os quais onze apresentavam a associação de algum tipo de cefaléia e MC-1, sendo a dor de cabeça avaliada por uma ficha clínica padronizada, na qual constavam quesitos relativos à localização, duração, fatores precipitantes, caráter e evolução da dor. Dentre os 11 pacientes estudados, cinc...

  17. Ictiosis congénita tipo laminar, reporte de un caso.

    OpenAIRE

    Joaquín Saavedra D.; María José Sierralta S.; Cristian Saavedra D; Vanesa Rivera C; Francisco Cerda C.

    2014-01-01

    RESUMEN INTRODUCCIÓN: La ictiosis tipo laminar es una enfermedad dermatológica infrecuente perteneciente al grupo de las llamadas genodermatosis. Es una forma de ictiosis congénita que es evidente desde el nacimiento. PRESENTACIÓN DEL CASO: Recién nacido por cesárea, sexo masculino, de 36 semanas de gestación, adecuado para la edad gestacional y con APGAR 8. Antecedentes familiares: padres no consanguíneos y hermano con ictiosis tipo laminar. Luego de nacer es hospital...

  18. PENGENDALIAN KUALITAS PT AHM DENGAN MENGGUNAKAN ISO/TS 16949: 2002 UNTUK MENCEGAH KOMPONEN VALVE INLET BENGKOK PADA MOTOR SUPRA KHUSUSNYA MESIN NF100 (Studi Kasus Valve Inlet Bengkok di PT Astra Honda Motor

    Directory of Open Access Journals (Sweden)

    Naniek Utami Handayani

    2012-02-01

    Full Text Available Untuk memenuhi keinginan konsumen dalam hal mutu dan jumlah, PT AHM telah menerapkan ISO 9001:2000 (International Standard Organization versi tahun 2000, SIX SIGMA dan ISO/TS 16949:2002 untuk menangani customer claim dan memperbaiki mutu supplier yang ada. Sebelum penerapan ISO/TS 16949:2002, untuk keharmonisan kualitas supplier/penyalur tersebut, PT AHM telah menggunakan QS-9000 dalam mengendalikan kualitas produknya. Berhubung QS-9000 tidak diperbaharui lagi dan hanya akan berlaku sampai tahun 2006, maka sebagai gantinya perusahaan mengambil kebijakan untuk menerapkan ISO/TS 16949:2002 dan menyertakan dalam keseluruhannya kebutuhan ISO 9001:2000. Dari beberapa jenis motor yang diproduksi pada pabrik II dari PT AHM, jenis motor yang diproduksi adalah Legenda, Tiger, GL Max, Mega Pro dan Supra. Diantara kelima motor tersebut, Supra mempunyai prosentase permintaan yang paling tinggi dan juga sekaligus market claim tertingggi (periode Agustus s/d Desember 2004, yaitu sebesar 2,7%, sedangkan berdasarkan penelitian terhadap banyaknya claim customer terhadap komponen motor Supra periode Agustus s/d Desember 2004, claim terhadap komponen  terbesar mencapai 337 claim dari total 1440 claim. Komponen  motor Supra yang dimaksud disini adalah Valve Inlet. Dalam penelitian ini, dievaluasi hasil dari pelaksanaan persiapan penerapan ISO/TS 16949:2002 sebagai teknik pengendalian kualitas terbaru yang telah dipilih dengan menggunakan tools dari ISO/TS 16949:2002 yaitu SPC, FMEA dan Corrective Action. Hasil penelitian ini menunjukkan bahwa penyebab Valve Inlet bengkok bukan hanya berasal dari Valve inlet itu sendiri, melainkan juga sebagai akibat dari adanya ketidaksesuaian pada Guide Valve Inlet dan Cylinder head. Dari penelitian penerapan ISO/TS 16949:2002 di PT AHM dapat diketahui beberapa manfaat ISO/TS 16949:2002 dalam mengendalikan kualitas produk dan memenuhi kebutuhan customer. Kata Kunci: Market Claim, Customer Claim, ISO/TS 16949:2002, SPC, FMEA dan

  19. Estimulación de diferentes tipos de inteligencias a través de los videojuegos

    OpenAIRE

    Aliciardi, Agustina; De Cunto, Guillermo; Marcucci, Ricardo Martín

    2016-01-01

    Existen diferentes tipos de inteligencia (lógico-matemática, verbal-lingüística, corporal-cinestésica, musical, naturalista, visual-espacial, interpersonal, intrapersonal). Conocer las habilidades y capacidades típicas de cada tipo de inteligencia permite saber que tipo de actividades realizar para estimularlas y lograr generar un desarrollo más equilibrado, que le permita a las personas maximizar su potencial aprovechando sus fortalezas. Debido a esto, se investigaron diferentes tipos de jue...

  20. Ocorrências iatrogênicas com medicação em Unidade de Terapia Intensiva: condutas adotadas e sentimentos expressos pelos enfermeiros Ocurrencias iatrogénicas com medicamentos en Unidad de Cuidados Intensivos: conductas y sentimientos de los enfermeros Iatrogenic occurrences with medication in I. C.U: nurse's procedures and feelings

    Directory of Open Access Journals (Sweden)

    Katia Grillo Padilha

    2002-03-01

    Full Text Available Ocorrências iatrogênicas com medicação na UTI são eventos indesejáveis que exigem pronta intervenção do enfermeiro. Opresente estudo foi realizado com os seguintes objetivos:- verificar a conduta dos enfermeiros diante de uma ocorrência commedicação, identificar os sentimentos vividos nessas situações e caracterizar os fatores relacionados a esses eventos. Pormeio de um questionário respondido por 148 enfermeiros de UTI (76,7% de 7 hospitais do Município de São Paulo, nosanos de 1997 e 1998, os dados foram obtidos e analisados segundo freqüência absoluta e percentual. Os resultados permitiramconcluir que as condutas mais citadas incluíram: comunicar o fato ao médico (31,7%, intensificar os controles (26,5% ecomunicar a chefia de enfermagem (13,5%. Ansiedade, impotência e culpa foram sentimentos mais apontados com38,1%, 14,6% e 12,3%, respectivamente. O fator relacionado às ocorrências mais freqüente foi a displicência do funcionário(23,1%. Quanto à vivência desse tipo de ocorrência, a maior porcentagem (43,2% referiu ter vivido situação semelhanteraras vezes.Ocurrencias iatrogénicas com medicamentos en UCI no son hechos esperados y necesitan rápida actuación de los enfermeros.El estudio tuvo los siguientes objectivos: verificar la conducta de los enfermeros delante de una ocurrencia iatrogénica commedicamnetos; identificar los sentimientos provocados por tales situaciones y identificar los factores vinculados a talesocurrencias. Ciento cuarenta ocho enfermeros (76,7% de 7 UCI de la ciudad de São Paulo, Brasil, contestaran una encuestaen los años de 1997 y 1998. Los resultados llevan a concluir que las conductas más frecuentes incluyeran: comunicar elhecho al médico (31,7%, aumentar los controles (26,5% y comunicar el hecho al director de enfermería (13,5%. Ansiedad(38,1%, impotencia (14,6% y culpa (12,3%fueranlos sentimientos más frecuentes. El factor más importante relacionado a las ocurrencias iatrg

  1. Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome.

    Science.gov (United States)

    Stagni, Fiorenza; Giacomini, Andrea; Emili, Marco; Trazzi, Stefania; Guidi, Sandra; Sassi, Martina; Ciani, Elisabetta; Rimondini, Roberto; Bartesaghi, Renata

    2016-10-01

    Cognitive disability is an unavoidable feature of Down syndrome (DS), a genetic disorder due to the triplication of human chromosome 21. DS is associated with alterations of neurogenesis, neuron maturation and connectivity that are already present at prenatal life stages. Recent evidence shows that pharmacotherapies can have a large impact on the trisomic brain provided that they are administered perinatally. Epigallocatechin-3-gallate (EGCG), the major polyphenol of green tea, performs many actions in the brain, including inhibition of DYRK1A, a kinase that is over-expressed in the DS brain and contributes to the DS phenotype. Young adults with DS treated with EGCG exhibit some cognitive benefits, although these effects disappear with time. We deemed it extremely important, however, to establish whether treatment with EGCG at the initial stages of brain development leads to plastic changes that outlast treatment cessation. In the current study, we exploited the Ts65Dn mouse model of DS in order to establish whether pharmacotherapy with EGCG during peak of neurogenesis in the hippocampal dentate gyrus (DG) enduringly restores hippocampal development and memory performance. Euploid and Ts65Dn mice were treated with EGCG from postnatal day 3 (P3) to P15. The effects of treatment were examined at its cessation (at P15) or after one month (at P45). We found that at P15 treated trisomic pups exhibited restoration of neurogenesis, total hippocampal granule cell number and levels of pre- and postsynaptic proteins in the DG, hippocampus and neocortex. However, at P45 none of these effects were still present, nor did treated Ts65Dn mice exhibit any improvement in hippocampus-dependent tasks. These findings show that treatment with EGCG carried out in the neonatal period rescues numerous trisomy-linked brain alterations. However, even during this, the most critical time window for hippocampal development, EGCG does not elicit enduring effects on the hippocampal physiology

  2. Approches des pratiques rituelles. Proposition de restitution à partirdes dépôts terrestres non funéraires à composante métallique

    OpenAIRE

    Bataille , Gérard

    2012-01-01

    International audience; Le développement de ce type de réflexion sur lesensembles de dépôts permettra de mieux définir lesrituels et l’organisation “technique” de ces derniers,qu’ils soient religieux ou non. La description deschaînes opératoires, qu’on peut également nommerprocessus rituels, est une clef de compréhensiondes pratiques, des croyances et des religions de cessociétés. Cette approche des pratiques de dépositions’intègre pleinement dans le champ disciplinairede l’archéologie du rit...

  3. Control System Analyses for the Driver Gas Fill System of the BRL 1/6th Scale LB/TS Test Facility

    Science.gov (United States)

    1993-04-01

    AD-A264 476 Control System Analyses for the Driver Gas Fill System of the BRL 1/6th Scale LB /i’S Test Facility Duane T. Hove Gregory P. Mason ARL-CR...Analyses for the Driver Gas Fill System of the BRL 1/6th Scale LB /TS Test Facility C: DAAA15-90-D-1002 Task 1 6. AUTHOR(S) Duane T. Hove and Gregory P...663 OK) is achieved with a secondary valve relative opening of 0.2 to 0.5 as the primary valve relative opening ranges from 0.25 to 1.0 (Figure 3). 7

  4. Uso de neumocitos de tipo II en el tratamiento de enfermedades pulmonares asociadas con fibrosis pulmonar

    OpenAIRE

    Serrano-Mollar, Anna; Closa, Daniel; Bulbena, Oriol

    2005-01-01

    Se describe el empleo de neumocitos tipo II como agentes inhibidores de la proliferación de fibroblastos, por lo que pueden ser utilizados en la elaboración de un medicamento para el tratamientode enfermedades pulmonares que cursan con fibrosis pulmonar.

  5. CORRELACION ENTRE DISTINTOS TIPOS HISTOLOGICOS DE CANCER DE MAMA Y RECEPTORES ESTROGENICOS

    OpenAIRE

    Schiaffino O.,Rodrigo; Ibarra P.,Andrés; González A.,Raúl; Urrutia M.,Julio

    2002-01-01

    Se presentan los resultados de 140 muestras histológicas tomadas en pacientes con cáncer de mama para determinar su concentración de receptores de estrógenos. Destaca la importancia, frecuencia de positividad para receptores de estrógenos en todos los tipos histológicos

  6. I "limiti" del reato di associazione di tipo mafioso di fronte alle "mafie in trasferta"

    Directory of Open Access Journals (Sweden)

    Alain Maria Dell’Osso

    2016-12-01

    Full Text Available Nelle regioni dell’Italia settentrionale si assiste da tempo all’emersione di cellule criminali, anche embrionali, legate e affiliate alle mafie storiche e, in specie, alla ‘ndrangheta: nei relativi procedimenti penali si è posta la questione della configurabilità, per ciascuna di esse, di un’autonoma associazione di tipo mafioso, che deriverebbe i caratteri di mafiosità dall’associazione madre. Il saggio richiama l’attenzione sull’esigenza di una puntuale verifica dei requisiti di fattispecie del reato previsto dall’art. 416-bis c.p. in relazione alla singola associazione, circostanza che complica la possibilità di ravvisare, di volta in volta, un’associazione autonomamente rilevante. Parole chiave: associazione di tipo mafioso; nuove mafie; ‘ndrangheta; metodo mafioso; locali. Recently, in Northern Italy, came to light many small criminal groups affiliated to the huge criminal organization known as ‘Ndrangheta. This organization certainly represents one of the most important form of Mafia. The essay aims to clarify if it is correct to consider even the single small group as “mafioso”. Such a label has extremely relevant consequences: in particular, it allows to prosecute the group as an “associazione di tipo mafioso” under section 416-bis of the Italian Penal Code. Keywords: Organized crime; ‘ndrangheta; Characteristics of mafia; elements of the crime of “associazione di tipo mafioso”; mafia local cells.

  7. Influencia del contacto precoz, nacionalidad, tipo de parto y prematuridad en la lactancia materna

    Directory of Open Access Journals (Sweden)

    Ana Belén Laviña Castan

    2015-01-01

    Full Text Available Conocer si en el HUMS existe asociación entre lactancia materna y nacionalidad, prematuridad, tipo de parto, contacto precoz piel con piel. Estudio de cohortes, en una muestra de 541 puérperas del HUMS en octubre-noviembre 2011. Las variables: nacionalidad, tipo de parto, contacto precoz, parto prematuro e inicio lactancia materna se recogieron antes del alta hospitalaria mediante cuestionario. A los dos meses postparto se contactó telefónicamente con las madres para conocer el tipo de lactancia en ese momento. El 70,32 % iniciaron la lactancia materna en las dos primeras horas postparto y el 55,58% daban Lactancia materna exclusiva (LME a los dos meses. Influyen en la lactancia materna el tipo de parto, contacto precoz y parto prematuro. La probabilidad de lactancia materna es 3,65 veces más alta si se ha realizado contacto precoz (RR 3,65; IC 95% 2,72-4,88; p=0,001. El inicio de lactancia materna en las 2 primeras horas y la nacionalidad española influye positivamente en la LME a los 2 meses. Las prácticas hospitalarias en el postparto deben promover el contacto precoz madre-recién nacido y el inicio de lactancia materna en las dos primeras horas, principalmente en las cesáreas.

  8. Medicamentos para la Diabetes Tipo 2. Lo Nuevo y Lo Tradicional.

    Directory of Open Access Journals (Sweden)

    Alfredo Jácome Roca

    2008-06-01

    Uno de los más importantes estudios fue el UKPDS, básico para el manejo integral del diabético tipo 2. Las implicaciones más importantes de este estudio tuvieron que ver con las complicaciones micro y macrovasculares.

  9. Factores de riesgo de diabetes mellitus tipo 2 en mujeres postmenopaúsicas

    OpenAIRE

    Acosta Naranjo, William Daniel; Esnal, Virginia

    2012-01-01

    La Diabetes Mellitus tipo 2 (DM 2) es una enfermedad con impacto socio sanitario por su elevada frecuencia y mortalidad cardiovascular. En Uruguay, como en la población mundial, la DM2 es más frecuente en mujeres. Este trabajo describe factores de riesgo en mujeres postmenopaúsicas que nosotros, los investigadores de este manuscrito, atendemos.

  10. Quebrando estereótipos e rompendo preconceitos na sala de aula

    Directory of Open Access Journals (Sweden)

    Daniela Jakubaszko

    2015-04-01

    Full Text Available Este texto se preocupa em contribuir para a reflexão que torna possível a identificação e ruptura dos estereótipos sociais que dão origem a preconceitos e ações discriminatórias. Com base nos estudos de Walter Lippann, Agnes Heller, Adam Shaff e Eclea Bosi, pretende-se discutir os conceitos de estereótipo e preconceito, buscando entender o que são e porque se formam. Para entender melhor o estereótipo temos que refletir sobre três elementos que a ele se ligam: a linguagem, o cotidiano e o senso comum. É no plano da linguagem - do diálogo e das práticas de linguagem - que se deve estudar e se pode romper e desconstruir os estereótipos, tomando consciência da própria formação discursiva. O texto oferece, ainda, algumas sugestões para trabalhar o conceito na sala de aula e para ampliar o repertório de textos e referências a serem debatidas com os alunos.

  11. Molecular Cloning of a cDNA Encoding for Taenia solium TATA-Box Binding Protein 1 (TsTBP1) and Study of Its Interactions with the TATA-Box of Actin 5 and Typical 2-Cys Peroxiredoxin Genes.

    Science.gov (United States)

    Rodríguez-Lima, Oscar; García-Gutierrez, Ponciano; Jiménez, Lucía; Zarain-Herzberg, Ángel; Lazzarini, Roberto; Landa, Abraham

    2015-01-01

    TATA-box binding protein (TBP) is an essential regulatory transcription factor for the TATA-box and TATA-box-less gene promoters. We report the cloning and characterization of a full-length cDNA that encodes a Taenia solium TATA-box binding protein 1 (TsTBP1). Deduced amino acid composition from its nucleotide sequence revealed that encodes a protein of 238 residues with a predicted molecular weight of 26.7 kDa, and a theoretical pI of 10.6. The NH2-terminal domain shows no conservation when compared with to pig and human TBP1s. However, it shows high conservation in size and amino acid identity with taeniids TBP1s. In contrast, the TsTBP1 COOH-terminal domain is highly conserved among organisms, and contains the amino acids involved in interactions with the TATA-box, as well as with TFIIA and TFIIB. In silico TsTBP1 modeling reveals that the COOH-terminal domain forms the classical saddle structure of the TBP family, with one α-helix at the end, not present in pig and human. Native TsTBP1 was detected in T. solium cysticerci´s nuclear extract by western blot using rabbit antibodies generated against two synthetic peptides located in the NH2 and COOH-terminal domains of TsTBP1. These antibodies, through immunofluorescence technique, identified the TBP1 in the nucleus of cells that form the bladder wall of cysticerci of Taenia crassiceps, an organism close related to T. solium. Electrophoretic mobility shift assays using nuclear extracts from T. solium cysticerci and antibodies against the NH2-terminal domain of TsTBP1 showed the interaction of native TsTBP1 with the TATA-box present in T. solium actin 5 (pAT5) and 2-Cys peroxiredoxin (Ts2-CysPrx) gene promoters; in contrast, when antibodies against the anti-COOH-terminal domain of TsTBP1 were used, they inhibited the binding of TsTBP1 to the TATA-box of the pAT5 promoter gene.

  12. Tipo de tratamiento farmacológico y deterioro de la función pulmonar en pacientes con diabetes tipo 2

    OpenAIRE

    Vargas Diaz, Henry Alexander; Dennis Verano, Rodolfo José

    2013-01-01

    Antecedentes: En la actualidad no es clara la relación de la DM 2 con respecto al deterioro de la función pulmonar y menos aún si el tipo de tratamiento modifica parámetros espirométricos e inflamatorios. Objetivo: Comparar la función pulmonar de pacientes con DM 2 tratados con metformina vs secretagogos y la combinación con insulinas. Establecer el nivel de biomarcadores inflamatorios entre los grupos de tratamiento. Metodología: Estudio observacional analítico de corte transversal 495 pacie...

  13. EFECTO DEL TIPO Y TIEMPO DE FERMENTACIÓN EN LA CALIDAD FÍSICA Y QUÍMICA DEL CACAO (Theobroma cacao L.) TIPO NACIONAL

    OpenAIRE

    Rubén Darío Rivera Fernández; Alexandra Elizabeth Barrera Álvarez; Ángel Monserrate Guzmán Cedeño; Hugo Nolti Medina Quinteros; Lola Margarita Casanova Ferrín; Mayra Mercedes Peña Galeas; Pedro Eduardo Nivela Morante

    2012-01-01

    La presente investigación tuvo como objetivo evaluar los tipos de fermentadores y los diferentes tiempos de fermentación usados por los productores de cacao de la zona norte y central de la provincia de Manabí-Ecuador. Se estudiaron cuatro fermentadores: saco de yute, montón, caja de madera y tina plástica, con una capacidad para almacenar 60 kg de cacao y tiempos de fermentación de 2 a 5 días; además, se evaluó un testigo (sin fermentar). El diseño fue bloques completos al azar en arreglo fa...

  14. INVESTIGATIONS ON THE MYCOFLORA AND PROCESSING EFFECTS ON THE NUTRITIONAL QUALITY OF PEANUT (ARACHIS HYPOGEA L. VAR. TS 32-1

    Directory of Open Access Journals (Sweden)

    Euloge S. Adjou

    2012-12-01

    Full Text Available The microbiological and nutritional characterization of peanut (Arachis hypogea L var. TS 32-1 was investigated. Bacteria and fungi were isolated from this product. The fungal isolates were Aspergillus niger, Aspergillus flavus, Aspergillus parasiticus Speare, Aspergillus ochraceus Wilhelm and Fusarium poae. The respective mean moisture content and total acidity in samples were 8.19 ± 0.01% and 1.2 ± 0.02%. Nutritional analysis showed that peanut (Arachis hypogea L var. TS 32-1 has interesting nutritional potential. Carbohydrate content (7.84 ± 0.3%, protein content (33.88 ± 0.1%, fat (47.48 ± 0.01% and the presence of minerals such as calcium (0.25 ± 0.05g/kg, potassium (5.21 ± 0.02g/kg and magnesium (1.92 ± 0.03% allowed its application as supplement in infant feeding in rural areas. Anti-nutritional factors such as oxalate and phytate were also detected in samples. This nutritional potential is significantly affect by thermal processes which can reduce essentially protein and carbohydrate contents and also anti-nutritional factor levels. However, values were lower than established toxic level. Finally, more attention should be made to its microbial quality in order to preserve children’s health.

  15. Micro-matrix solid-phase dispersion coupled with MEEKC for quantitative analysis of lignans in Schisandrae Chinensis Fructus using molecular sieve TS-1 as a sorbent.

    Science.gov (United States)

    Chu, Chu; Wei, Mengmeng; Wang, Shan; Zheng, Liqiong; He, Zheng; Cao, Jun; Yan, Jizhong

    2017-09-15

    A simple and effective method was developed for determining lignans in Schisandrae Chinensis Fructus by using a micro-matrix solid phase dispersion (MSPD) technique coupled with microemulsion electrokinetic chromatography (MEEKC). Molecular sieve, TS-1, was applied as a solid supporting material in micro MSPD extraction for the first time. Parameters that affect extraction efficiency, such as type of dispersant, mass ratio of the sample to the dispersant, grinding time, elution solvent and volume were optimized. The optimal extraction conditions involve dispersing 25mg of powdered Schisandrae samples with 50mg of TS-1 by a mortar and pestle. A grinding time of 150s was adopted. The blend was then transferred to a solid-phase extraction cartridge and the target analytes were eluted with 500μL of methanol. Moreover, several parameters affecting MEEKC separation were studied, including the type of oil, SDS concentration, type and concentration of cosurfactant, and concentration of organic modifier. A satisfactory linearity (R>0.9998) was obtained, and the calculated limits of quantitation were less than 2.77μg/mL. Finally, the micro MSPD-MEEKC method was successfully applied to the analysis of lignans in complex Schisandrae fructus samples. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Nonlinear process generating Tollmien-Schlichting waves in a reattached boundary layer; Hakuri saifuchaku nagare ni okeru T-S hado no hisenkei reiki katei

    Energy Technology Data Exchange (ETDEWEB)

    Asai, M.; Aiba, K. [Tokyo Metropolitan Institute of Technology, Tokyo (Japan)

    1995-09-01

    Low-frequency Tollmien-Schlichting (T-S) waves may be thought generated as a result of high-frequency disturbance between two proximity frequency modes grown unstably in a separation shear layer causing secondary nonlinear interference to occur. This fact has been verified by a numerical simulation. A non-compression Navier-Stokes equation was used for the fundamental equation, a tertiary windward difference for the convection term, and a secondary central difference for other differential calculus. The Reynolds number was 200, and the disturbance was introduced by applying `v` variation continuously on the wall face. Non-introduction of the disturbance results in a steady flow. Disturbance frequencies of 0.15 and 0.20 were selected as disturbance frequencies from the relationship between the spatial amplification and the frequency dependency. The structure of the excited disturbance agreed with the intrinsic mode. The difference mode due to nonlinear interference grows as the basic mode was amplified. The basic mode decays sharply in the boundary layer after reattachment, while the difference mode decays slowly. Distribution of the difference mode is a distribution of viscous T-S waves, which may be converted into the intrinsic mode. 8 refs., 7 figs.

  17. Experimental data report for test TS-3 Reactivity Initiated Accident test in the NSRR with pre-irradiated BWR fuel rod

    International Nuclear Information System (INIS)

    Nakamura, Takehiko; Yoshinaga, Makio; Fujishiro, Toshio; Kobayashi, Shinsho; Yamahara, Takeshi; Sukegawa, Tomohide; Kikuchi, Teruo; Sobajima, Makoto.

    1993-09-01

    This report presents experimental data for Test TS-3 which was the third test in a series of Reactivity Initiated Accident (RIA) tests using pre-irradiated BWR fuel rods, performed in the Nuclear Safety Research Reactor (NSRR) in September, 1990. Test fuel rod used in the Test TS-3 was a short-sized BWR (7 x 7) type rod which was re-fabricated from a commercial rod irradiated in the Tsuruga Unit 1 power reactor of Japan Atomic Power Co. The fuel had an initial enrichment of 2.79 % and a burnup of 26 Gwd/tU. A pulse irradiation of the test fuel rod was performed under a cooling condition of stagnant water at atmospheric pressure and at ambient temperature which simulated a BWR's cold start-up RIA event. The energy deposition of the fuel rod in this test was evaluated to be 94 ± 4 cal/g · fuel (88 ± 4 cal/g · fuel in peak fuel enthalpy) and no fuel failure was observed. Descriptions on test conditions, test procedures, transient behavior of the test rod during the pulse irradiation, and results of pre-pulse and post-pulse irradiation examinations are described in this report. (author)

  18. Processing yield of Nile tilapia (Oreochromis niloticus: head cut types and two weight classes Rendimento do processamento da tilápia-do-nilo (Oreochromis niloticus: tipos de corte da cabeça em duas categorias de peso

    Directory of Open Access Journals (Sweden)

    Maria Luiza Rodrigues de Souza

    2000-05-01

    Full Text Available The aim of this study was to evaluate the best type of head cut of Nile tilapia (Oreochromis niloticus resulting in better fillet processing yields. The experiment was carried out at the Pisciculture Station of UEM/Codapar, Maringá, Paraná, Brazil. One hundred and twenty specimens were slaughtered, head cut, eviscerated, and had their fin, skin and fillet removed. The fillet processing was undertaken by a single person. Plotting was completely randomized by a 2x3 factorial scheme. Treatments consisted of two weight categories ( W1=250-400g and W2=401-550g and three types of head cut (C1=oblique, OB; C2=Contour, CO, and C3=strainght, ST, with 20 replicates. Each fish was considered an experimental unit. Mean values of yield were expressed in relation to fish body weight. There was an influence of head cut types and weight categories on the dressed out and fillet yield. The yields in W2 (OB=50.42%, 35.27%; CO=50.70%, 35.18% and ST=48.50%, 33.82% were higher (p O objetivo do presente estudo foi avaliar o melhor tipo de corte de cabeça para decapitação da tilápia-do-nilo (Oreochromis niloticus, que resulte em melhores rendimentos de filetagem. O experimento foi conduzido na Estação de Piscicultura da UEM/Codapar, Maringá, PR. Foram abatidos 120 exemplares cortadas as cabeças, eviscerados, removidas as nadadeiras, pele e filés. O processo de filetagem foi realizado por uma única pessoa. O delineamento foi inteiramente casualizado, em esquema fatorial 2x3. Os tratamentos foram: duas categorias de peso (P1= 250-400 g e P2= 401-550 g e três tipos de corte de cabeça (C1=oblíquo, OB; C2=contornado, CO e C3=reto, RE, com 20 repetições. Cada peixe foi considerado a unidade experimental. Os valores médios de rendimento foram expressos em relação ao peso corporal do peixe. Houve influência do tipo de corte e categoria de peso sobre o rendimento do tronco limpo e filé. Os rendimentos em P2 (OB=50,42%, 35,27%; CO=50,70%, 35,18% e RE=48

  19. Seleção de genótipos de Brachiaria Ruziziensis quanto ao alumínio em solução nutritiva: II: Avaliação da tolerância ao alumínio Brachiaria Ruziziensis genotypes selection: II: Evaluation of the aluminum tolerance

    Directory of Open Access Journals (Sweden)

    Paulo Sérgio Balbino Miguel

    2011-01-01

    Full Text Available O alumínio, em solos ácidos, é um dos principais responsáveis pela baixa produtividade de culturas. O objetivo deste trabalho foi avaliar a variabilidade genética da Brachiaria ruziziensis para a tolerância ao alumínio. Foram utilizados 10 genótipos da espécie referida, crescidas em vasos com 0, 30 e 60 mg/L de alumínio em solução nutritiva. Foi utilizado o delineamento inteiramente casualizado em esquema fatorial, com seis repetições e parcelas de uma planta por vaso. Foram avaliados: a produção de massa verde da parte aérea e raízes (MVPA e MVR, a produção de matéria seca da parte aérea e raízes (MSPA e MSR, o incremento no crescimento da parte aérea e das raízes (IPA e IR, expresso pela diferença entre o crescimento final e o inicial, e o incremento no número de perfilhos (INP. O aumento nas concentrações de alumínio provocou decréscimos para as médias de todas as características avaliadas, excetuando o IR. A ausência de diferenças do genótipo 8 para seis das sete características analisadas, com exceção da MVPA, demonstra ser ela a mais promissora para estudos posteriores em melhoramento, visando maior produtividade em solos ácidos. Os resultados evidenciaram a existência de variabilidade genética entre os genótipos avaliados para a tolerância ao alumínio tóxico, sendo possível identificar materiais mais produtivos na presença desse metal.In acid soils, the aluminum is responsible for the low cultures productivity. The objective of this work was to evaluate the Brachiaria ruziziensis genetic variability for the aluminum tolerance.10 genotypes of that species were used, grown in vases with 0, 30 and 60 mg/L of aluminum in nutritious solution. A completely randomized design under 10 x 3 factorial, with six replicates. The following variables were evaluated: the green mass production of the aerial part and roots (MVPA and MVR, the dry matter production of the aerial part and roots (MSPA and MSR

  20. Avaliação da composição química de milho seco e armazenado em silo tipo alambrado com ar natural forçado Evaluation of chemical composition of corn dried and stored with forced natural air

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Gutkoski

    2009-12-01

    Full Text Available O trabalho objetivou estudar o efeito da umidade de colheita e do tempo de armazenamento em grãos de milho secos e armazenados em silos com ar natural forçado. Grãos de milho colhidos com 17,8; 18,9 e 20,5% de água foram acondicionados em silos tipo alambrado com fundo falso perfurado e com ventiladores ligados ininterruptamente até a secagem. Amostras de milho foram coletadas nos tempos zero, 4, 8, 22 e 112 dias, em seis alturas de camada de cada silo (10, 60, 110, 160, 210 e 260 cm. A composição química foi determinada pelo uso de Espectrofotômetro do Infravermelho Proximal (NIR e os resultados expressos em porcentagem e em base seca. Os dados foram analisados estatisticamente (Anova e nas interações significativas, elaborados os gráficos de regressão. Nas determinações de proteínas, lipídios, matéria seca e fibra em detergente neutro as interações foram significativas ao nível de 5% de probabilidade de erro, enquanto que em cinzas, umidade e carboidratos não foram verificadas diferenças significativas. A aeração natural forçada é capaz de reduzir a umidade do milho para 13%, sendo tecnicamente viável em propriedades familiares.The aim of this work was to study the effects of moisture at harvest and time of storage upon grains of corn dried and stored in bins with forced natural air. Grains of corn harvested with 17.8; 18.9, and 20.5% of water were stored in drying bins with false floor with fans working full-time until drying. Samples of corn were collected at zero, 4, 8, 22, and 112 days from six different heights in each bin (10, 60, 110, 160, 210 and 260 cm. The chemical composition was determined through Near-Infrared Spectrophotometer (NIR and the results were expressed in percentage at dry basis. The data were statistically analyzed (Anova and for the significant interactions graphics of regression were provided. In the process of determination of protein, fat, dry matter, and neutral detergent fiber the

  1. Resultados del recambio valvular pulmonar según el tipo de prótesis implantada

    OpenAIRE

    María García Vieites; Francisco Portela Torrón; Víctor Bautista Hernández; Laura Fernández Arias; Daniel Vásquez Echeverri; Isaac Martínez Bendayán; Beatriz Bouzas Zubeldía; Jose Joaquín Cuenca Castillo

    2017-01-01

    Introducción y objetivos: El recambio valvular pulmonar (RVP) es actualmente la intervención más frecuente de las cardiopatías congénitas del adulto. Existen numerosas controversias sobre cuándo implantar una prótesis y; sobre todo, acerca de cuál es el sustituto ideal. El objetivo del estudio es revisar el resultado de 3 tipos de prótesis biológicas implantadas en nuestro centro. Métodos: Desde 2003 se implantaron 3 tipos de prótesis biológicas en diferentes momentos: grupo 1-prótesis Med...

  2. Depressão e estresse: existe um endofenótipo?

    OpenAIRE

    Mello,Andrea Feijo; Juruena,Mario Francisco; Pariante,Carmine M; Tyrka,Audrey R; Price,Lawrence H; Carpenter,Linda L; Del Porto,Jose Alberto

    2007-01-01

    OBJETIVO: Revisar os achados recentes sobre a relação entre estresse, eixo hipotálamo-pituitária-adrenal e depressão, na tentativa de explicar um endofenótipo de vulnerabilidade para o desenvolvimento da depressão. MÉTODO: Revisão não sistemática da literatura baseada na hipótese de endofenótipo. RESULTADOS: A depressão está relacionada à hipercortisolemia em muitos pacientes; porém, nem todos os deprimidos apresentam esta alteração na função hipotálamo-pituitária-adrenal. Os primeiros estudo...

  3. Metodología y clasificación de tipos de paisaje en Galicia

    Directory of Open Access Journals (Sweden)

    Augusto Pérez-Alberti

    2014-12-01

    Full Text Available En el presente artículo se exponen los resultados de las investigaciones llevadas a cabo con el fin de caracterizar los diferentes tipos de paisaje existentes en Galicia (Noroeste de España. Se ha considerado el paisaje como resultado de un sistema dinámico en que interaccionan elementos estructurales y texturales. El resultado ha sido la caracterización de 6 grupos de paisaje, en función del dominio de la dinámica natural o antrópica y 28 tipos de paisaje sobre los que incidir de forma directa de cara a su protección, gestión y ordenación.

  4. Estudio de las tensiones en válvulas biplanas tipo mariposa

    Directory of Open Access Journals (Sweden)

    Tiberiu Manescu

    2003-01-01

    Full Text Available En este trabajo se presenta el estudio de las tensiones que se desarrollan durante la actuación estática de una válvula biplana, del tipo mariposa, que tiene un diámetro de 1.500 mm, cargada a la presión de 1 MPa. Para el análisis se utilizó el método de los elementos finitos y los cálculos fueron verificados experimentalmente mediante la técnica de la tensiometría eléctrica resistiva. Es muy importante conocer el comportamiento de estos tipos de válvula en funcionamiento para controlar las pérdidas admisibles.

  5. CARACTERIZACIÓN DE LUMINARIAS TIPO HALURO METÁLICO ANTE EVENTOS SAG

    Directory of Open Access Journals (Sweden)

    Bonie Johana Restrepo Cuestas

    Full Text Available Este artículo plantea una metodología para la caracterización de luminarias de haluro metálico, ante eventos sag. Inicialmente, se diseñó y construyó un generador de eventos sag. Luego, se planteó un esquema de pruebas, que fue utilizado para analizar el comportamiento de un tipo de luminarias de alta densidad de descarga tipo Metal Halide, ante eventos sag. Finalmente, tomando como referente el estándar SEMI F-47, se realizó la construcción de una curva característica que muestra la región de operación de la luminaria.

  6. Feminicídios: conceitos, tipos e cenários

    Directory of Open Access Journals (Sweden)

    Stela Nazareth Meneghel

    Full Text Available Resumo Este texto é um ensaio teórico que discute os conceitos, os tipos e os cenários de feminicídios e apresenta algumas propostas para a prevenção destas mortes prematuras, injustas e evitáveis. O texto traz o conceito original de femicídio proposto por Diana Russel e Jane Caputti, caracteriza tipos e mostra cenários novos e antigos onde estes crimes ocorrem. Aponta o patriarcado, entendido como sistema hierárquico de poder entre homens e mulheres, como um dos principais determinantes destas mortes. Finaliza apresentando ações e propostas para prevenir e combater estes crimes de gênero.

  7. EFEITO DO TIPO DE CAPTURA DOS FRANGOS DE CORTE SOBRE A QUALIDADE DA CARCAÇA

    Directory of Open Access Journals (Sweden)

    José Henrique Stringhini

    2006-10-01

    Full Text Available O experimento teve como objetivo avaliar a influência do tipo de captura de frango de corte sobre o número de contusões e fraturas hemorrágicas na carcaça, observadas no abatedouro. Utilizaram-se 10 lotes de 18.000 frangos, em granjas integradas. Testaram-se dois tipos de pega, pelo dorso e pelo pescoço, em frangos de corte com a idade média de abate de 45 dias. Foi aplicado o teste de Qui-Quadrado, usando-se a tabela de contigência 2x2. Os resultados demonstraram que o número de contusões e fraturas hemorrágicas foi significativamente maior nos lotes onde a captura das aves foi realizada pelo pescoço. PALAVRAS-CHAVE: Frango de corte, captura, qualidade de carcaça.

  8. A flavonoid agonist of the TrkB receptor for BDNF improves hippocampal neurogenesis and hippocampus-dependent memory in the Ts65Dn mouse model of DS.

    Science.gov (United States)

    Stagni, Fiorenza; Giacomini, Andrea; Guidi, Sandra; Emili, Marco; Uguagliati, Beatrice; Salvalai, Maria Elisa; Bortolotto, Valeria; Grilli, Mariagrazia; Rimondini, Roberto; Bartesaghi, Renata

    2017-12-01

    Intellectual disability is the unavoidable hallmark of Down syndrome (DS), with a heavy impact on public health. Reduced neurogenesis and impaired neuron maturation are considered major determinants of altered brain function in DS. Since the DS brain starts at a disadvantage, attempts to rescue neurogenesis and neuron maturation should take place as soon as possible. The brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a key role in brain development by specifically binding to tropomyosin-related kinase receptor B (TrkB). Systemic BDNF administration is impracticable because BDNF has a poor blood-brain barrier penetration. Recent screening of a chemical library has identified a flavone derivative, 7,8-dihydroxyflavone (7,8-DHF), a small-molecule that crosses the blood-brain barrier and binds with high affinity and specificity to the TrkB receptor. The therapeutic potential of TrkB agonists for neurogenesis improvement in DS has never been examined. The goal of our study was to establish whether it is possible to restore brain development in the Ts65Dn mouse model of DS by targeting the TrkB receptor with 7,8-DHF. Ts65Dn mice subcutaneously injected with 7,8-DHF in the neonatal period P3-P15 exhibited a large increase in the number of neural precursor cells in the dentate gyrus and restoration of granule cell number, density of dendritic spines and levels of the presynaptic protein synaptophysin. In order to establish the functional outcome of treatment, mice were treated with 7,8-DHF from P3 to adolescence (P45-50) and were tested with the Morris Water Maze. Treated Ts65Dn mice exhibited improvement of learning and memory, indicating that the recovery of the hippocampal anatomy translated into a functional rescue. Our study in a mouse model of DS provides novel evidence that treatment with 7,8-DHF during the early postnatal period restores the major trisomy-linked neurodevelopmental defects, suggesting that therapy with 7,8-DHF may represent a

  9. Desenvolvimento e estudos preliminares de estabilidade de formulações fotoprotetoras contendo Granlux GAI-45 TS®

    Directory of Open Access Journals (Sweden)

    M. CHORILLI

    2009-01-01

    Full Text Available

    A tendência atual no desenvolvimento de formulações fotoprotetoras é a associação de filtros químicos de amplo espectro e filtros físicos microparticulados fotoestáveis. Para assegurar a estabilidade do filtro é indispensável sua incorporação em veículo adequado que contribua para a melhora da aparência, do sensorial e da aceitação do produto pelo consumidor. O objetivo deste trabalho foi desenvolver e realizar estudos preliminares de estabilidade de formulações cosméticas para incorporação de 20% de filtro solar constituído por metil bisbenzotriazolil tetrametilbutil fenol e dióxido de titânio (Granlux GAI-45 TS®. As formulações selecionadas foram então acrescidas do filtro solar e novamente sujeitas à estudos preliminares de estabilidade. De um total de 20 formulações desenvolvidas, foram selecionados um gel fluido, um gel viscoso, um gel-creme e uma emulsão, aos quais incorporou-se o filtro solar. Após serem submetidas a estudos preliminares de estabilidade, as formulações não apresentaram variação de pH e mantiveram-se estáveis frente ao teste de centrifugação. Diante das condições experimentais, conclui-se que as formulações selecionadas apresentaram espalhabilidade adequada, oleosidade mínima, não apresentaram variação de pH e mantiveram-se estáveis frente ao teste de centrifugação, sendo excipientes adequados para incorporação do Granlux GAI-45 TS®. Palavras-chave: formulações fotoprotetoras; filtro físico; filtro químico; Granlux GAI-45 TS®; estudos preliminares de estabilidade.

  10. Un análisis del comportamiento del tipo de cambio real en Venezuela

    Directory of Open Access Journals (Sweden)

    Esmeralda Villegas

    2013-01-01

    Full Text Available El objetivo del artículo es la estimación del tipo de cambio real de equilibrio en Venezuela para el período 1999-2010. Se utilizó un marco analítico para el tipo de cambio basado en los fundamentos económicos. La evaluación empírica se basó en la técnica de análisis de cointegración y un modelo de corrección de errores a través del método de estimación de Mínimos Cuadrados Ordinarios (MCO. Para el cálculo del tipo de cambio real de equilibrio se hizo uso de los coeficientes estimados y los valores tendenciales de las variables fundamentales aproximadas por el filtro de Hodrick y Prescott. Se encontró una relación estable de largo plazo entre el tipo de cambio real, la productividad agregada, los términos de intercambio, el gasto del gobierno como porcentaje del producto interno bruto, los flujos de capital y el grado de apertura. En cuanto al modelo estimó episodios tanto de subvaluación como de sobrevaluación cambiaria. En concreto, se puede decir que existe una necesidad de combinar, del modo más adecuado, flexibilidad y credibilidad en la política cambiaria, en un contexto de políticas macroeconómicas consistentes.

  11. Adherencia terapéutica en personas con diabetes mellitus tipo 2

    Directory of Open Access Journals (Sweden)

    Mayerli Katherine Rincón-Romero

    2017-01-01

    Full Text Available Objetivo: determinar la adherencia terapéutica en personas con diabetes mellitus tipo 2 que asisten a una institución de salud, a través de la etiqueta Conducta terapéutica: enfermedad o lesión 1609 presentes. Materiales y Métodos: se realizó un estudio descriptivo de corte transversal con enfoque cuantitativo. La población de estudio estuvo conformada por 178 pacientes que cumplieron con los criterios de selección. Se obtuvo la caracterización sociodemográfica, funcionalidad y estado mental; se midió la adherencia terapéutica en escala de 1 menos adherente y 5 más adherente, con un instrumento validado basado en la etiqueta de resultado del Nursing Outcomes Classification de personas con diabetes mellitus tipo 2. Resultados: el 37.1 % de la población objeto de estudio era de sexo masculino, la ocupación predominante fue la dedicación al hogar, el principal nivel de escolaridad fue primaria, perteneciente en su mayoría a la religión católica, con una media de 11.5 de años de diagnóstico de diabetes tipo 2 y la adherencia terapéutica para la muestra estudiada mostró una media de 3,68. Conclusiones: en la muestra analizada de personas con diabetes tipo 2 se encontró una adherencia terapéutica entre en ocasiones manifestada y con frecuencia manifestada. El incumplimiento de actividad física prescrita es el factor que presentó mayores cifras de no adherencia.

  12. Inibidores da fosfodiesterase do tipo 5 e perda auditiva neurossensorial súbita

    Directory of Open Access Journals (Sweden)

    Monique Antunes de Souza Chelminski Barreto

    2013-12-01

    Full Text Available O uso de inibidores da fosfodiesterase do tipo 5 como sildenafil, vardenafil e tadalafil tem aumentado atualmente e alguns destes pacientes vêm apresentando perda auditiva neurossensorial súbita. OBJETIVO: Apresentar dois casos de pacientes que apresentaram surdez súbita em uso eventual do medicamento e revisar estudos sobre o uso de inibidores da fosfodiesterase do tipo 5 e surdez súbita. MÉTODO: Estudo analítico de dois casos e revisão sobre o tema no banco de dados da Pubmed/ MedLine e Bireme utilizando as palavras-chave inibidores da fosfodiesterase e surdez súbita e seus correlatos na língua inglesa. RESULTADOS: Os pacientes analisados são jovens, sem comorbidades, em uso de inibidores da fosfodiesterase do tipo 5 e após terapia combinada para o tratamento da surdez súbita, apenas um deles obteve melhora auditiva. Nove estudos científicos foram encontrados. Estudos pré-clínicos e clínicos, transversais e prospectivos foram revisados. CONCLUSÃO: O aumento da ocorrência na prática clínica e relatos científicos na literatura sugerem que o uso de inibidores da fosfodiesterase do tipo 5 seja encarado como fator de risco para surdez súbita. Novos estudos com amostras maiores e grupo controle são necessários para investigar esta associação.

  13. Poder y negociación del conflicto en diferentes tipos de matrimonio

    OpenAIRE

    Mirta Margarita Flores Galaz; Rolando Díaz Loving; Sofía Rivera Aragón; Ana Luisa Chi Cervera

    2005-01-01

    En el presente estudio se analizan los estilos de poder y los estilos de negociación del conflicto utilizados por parejas yucatecas, así como la relación entre cada uno de los factores de los estilos de poder y de negociación por tipo de matrimonio, de acuerdo a los ingresos individuales de las esposas y en nivel de trabajo.

  14. PREJUÍZOS COGNITIVOS EM IDOSOS COM DIABETES MELLITUS TIPO 2

    Directory of Open Access Journals (Sweden)

    Regina Maria Fernandes Lopes

    2009-01-01

    Full Text Available El avance en las condiciones de salud propicia el progresivo aumento de la esperanza de vida. Estudios han identificado la existencia de una conexión entre la Diabetes Mellitus (DM y demencia. La hiperglicemia podría ser un factor importante en la incidencia de la enfermedad de Azheimer, la cual puede ser una causa secundaria de demencia. La diabetes mellitus tipo 2 (DM2 está asociada con déficits cognitivos y funcionales, y el WCST es una de las herramientas que puede ser utilizada para evaluar funcionamiento ejecutivo. El objetivo de este estudio fue evaluar los déficits cognitivos de ancianos con diabetes mellitus tipo 2. Los participantes fueron 254 ancianos de ambos sexos, mayores de 60 años; 44 de ellos diagnosticados de DM2 y 210 en un grupo control de población general. El diseño fue un estudio cuantitativo transversal. Los instrumentos utilizados fueron: datos sociodemográficos, WCST, MMSE, BDI, BAI, GD, junto a las Sub pruebas de: Vocabulario, códigos, números y Cubos del WAIS-III. Los resultados mostraron una diferencia significativa en el desempeño de los ancianos con diabetes tipo 2 en comparación con el grupo control en cuatro descriptores de WCST que indicaban un deterioro. Igualmente los ancianos con diabetes tipo 2 mostraron una intensidad de síntomas depresivos y de ansiedad estadísticamente mayor que el grupo control

  15. Compactones, soluciones de ecuaciones no lineales con estructura tipo esferas duras

    OpenAIRE

    Máximo Agüero Granados; Jorge Bernal; Guadalupe Frias; Mauricio Paulin

    2001-01-01

    Se estudian ciertas soluciones de ecuaciones no lineales que modelan procesos físicos, que tienen semejanzas con estructuras coherentes del tipo de esferas duras, modelo de partículas muy usado en varias ramas de la física. Estas soluciones compactas (gotas, kinks, etcétera.) interactúan entre sí sólo a cortas distancias, porque no poseen colas infinitas como los solitones clásicos.

  16. Compactones, soluciones de ecuaciones no lineales con estructura tipo esferas duras

    Directory of Open Access Journals (Sweden)

    Máximo Agüero Granados

    2001-01-01

    Full Text Available Se estudian ciertas soluciones de ecuaciones no lineales que modelan procesos físicos, que tienen semejanzas con estructuras coherentes del tipo de esferas duras, modelo de partículas muy usado en varias ramas de la física. Estas soluciones compactas (gotas, kinks, etcétera. interactúan entre sí sólo a cortas distancias, porque no poseen colas infinitas como los solitones clásicos.

  17. Los diferentes tipos de hidroxiapatita y sus aplicaciones en cirugía bucal

    OpenAIRE

    Sánchez Garcés, Ma. Ángeles; Berini Aytés, Leonardo; Gay Escoda, Cosme

    1993-01-01

    Se describe las aplicaciones actuales de los diferentes tipos de hidroxiapatita en las técnicas quirúrgicas bucales practicadas con anestesia local que consisten en técnicas de tunelización subperióstica y el relleno de los defectos óseos y su aplicación combinada con implantes endo-óseos y las membranas de regeneración tisular guiada.

  18. Artículos científicos: tipos, secciones y publicación

    OpenAIRE

    Reverter Masià, Joaquín; Hernández González, Vicenç

    2012-01-01

    Las revistas científicas han sido el principal vehículo de transmisión de conocimientos entre los investigadores y la comunidad científica. Investigar y publicar un artículo científico son dos actividades íntimamente relacionadas. Saber los tipos de publicación existentes, las secciones de un artículo y donde publicarlo es el objetivo de este trabajo.

  19. EFECTO DEL TIPO Y TIEMPO DE FERMENTACIÓN EN LA CALIDAD FÍSICA Y QUÍMICA DEL CACAO (Theobroma cacao L. TIPO NACIONAL

    Directory of Open Access Journals (Sweden)

    Rubén Darío Rivera Fernández

    2012-07-01

    Full Text Available La presente investigación tuvo como objetivo evaluar los tipos de fermentadores y los diferentes tiempos de fermentación usados por los productores de cacao de la zona norte y central de la provincia de Manabí-Ecuador. Se estudiaron cuatro fermentadores: saco de yute, montón, caja de madera y tina plástica, con una capacidad para almacenar 60 kg de cacao y tiempos de fermentación de 2 a 5 días; además, se evaluó un testigo (sin fermentar. El diseño fue bloques completos al azar en arreglo factorial aditivo con tres réplicas. Los datos se analizaron mediante análisis de varianza con la prueba de Tukey al 5% de probabilidades. Se analizaron variables físicas: porcentaje de granos fermentados, violeta y pizarrosos (prueba de corte; y químicas: polifenoles (fotometría 760 nm, acidez volátil (arrastre de vapor y teobromina-cafeína (Cromatografía Líquida de Alta resolución, HPLC. El análisis de los resultados muestra que el tiempo de fermentación a diferencia del tipo de fermentador, tuvo influencia sobre las variables físicas y químicas analizadas. El aumento del porcentaje de granos fermentados y la disminución de los granos violetas ocurrieron desde el inicio hasta el final de la fermentación. La calidad química mejora con la reducción de la concentración de compuestos alcaloides y polifenoles, lo que repercute sobre las características organolépticas del cacao tipo Nacional. De los fermentadores y los tiempos utilizados por los productores se presentan las mejores características de calidad entre los cuatro y cinco días de fermentación en cajas de madera.

  20. Tipos de Ativismo Digital e Ativismo Preguiçoso no Mapa Cultural

    Directory of Open Access Journals (Sweden)

    Gabriela Bezerra Lima

    2012-08-01

    Full Text Available Este artigo se propõe a elencar os tipos de ativismo digital desenvolvidos por instituições e indivíduos e que estimulam o compartilhamento de suas mensagens nas redes sociais digitais. A partir da classificação dos tipos de ativismo digital (VEGH, 2003, propomos uma subclassificação do ativismo de ‘organização e mobilização’ e das ações de “ativismo preguiçoso” (MOROZOV, 2010 dos internautas. Para exemplificar os tipos de ativismo digital, este artigo observa as ações desenvolvidas na internet pela Fundação SOS Mata Atlântica. Nosso objetivo é analisar como os contratos de comunicação (CHARAUDEAU, 2006 de ativismo digital são percebidos e quais são seus níveis de contestação ao status quo no Mapa Cultural (DOUGLAS, 1998.

  1. A LEITURA COMO DESCONSTRUÇÃO DE ESTEREÓTIPOS

    Directory of Open Access Journals (Sweden)

    Waldivia Maria de Jesus

    2011-01-01

    Full Text Available A reflexão sobre leitura centra-se em estratégias de ensino com foco na desconstrução de imagens estereotipadas construídas social e culturalmente. Este artigo, de relato de pesquisa, estrutura-se em três etapas: quadro teórico, relato e argumentação. Engloba atividades de leitura desenvolvidas com uma classe de 22 alunos, do final do Ciclo II, da Educação de Jovens e Adultos, de uma escola Municipal situada em Santo Amaro, Zona Sul da cidade de São Paulo. O corpus deste estudo constitui-se por dois textos veiculados na mídia impressa, e fundamenta-se nas teorias de Protótipos e Estereótipos. (Taylor, 1989, (Hamilton & Trolier, 1996, (Sherman, 1996 e na Análise Crítica do Discurso (Van Djik, 1997 Palavras-chave: leitura, cognição social, desconstrução de estereótipos

  2. Efecto incretina en el tratamiento de la diabetes mellitus tipo 2

    Directory of Open Access Journals (Sweden)

    Manuel de Jesús Díaz Pérez

    2015-02-01

    Full Text Available El efecto incretina está dado por las funciones del polipéptido insulinotrópico dependiente de glucosa y un péptido similar a glucagón sobre la hiperglucemia en el organismo humano. Desde su descubrimiento ha cobrado un papel cada vez más significativo en la elaboración de nuevos fármacos normoglucemiantes, que logren el control metabólico de los pacientes con diabetes mellitus tipo 2. El objetivo de esta revisión es actualizar la información sobre el efecto incretina, su relación con la diabetes mellitus tipo 2, los fármacos cuyo mecanismo de acción se basa en este fenómeno fisiológico, así como las perspectivas para el futuro inmediato en este tema. Para ello se realizó una revisión bibliográfica, empleando servicios disponibles desde la red Infomed, específicamente: SciELO, Hinari, PubMed y EBSCO. Se resumen aspectos del sustrato fisiológico y fisiopatológico del efecto incretina y su aplicación en la terapéutica de los pacientes con diabetes mellitus tipo 2, así como los resultados positivos que se han logrado hasta el momento en este campo

  3. Comparison of distributed vortex receptivity coefficients at excitation of 3D TS-waves in presence and absence of surface waviness and pressure gradient

    Science.gov (United States)

    Borodulin, V. I.; Ivanov, A. V.; Kachanov, Y. S.; Mischenko, D. A.; Fedenkova, A. A.

    2016-10-01

    The paper is devoted to quantitative experimental investigation of effective mechanisms of excitation of 3D TS instability waves due to distributed boundary layer receptivity to free-stream vortices. Experiments carried out in a self-similar boundary layer with Hartree parameter βH = -0.115 and concentrated on studying two receptivity mechanisms connected with distributed scattering of 3D unsteady free-stream vortices both on the natural boundary layer nonuniformity (smooth surface) and on 2D surface nonuniformity (waviness). Obtained quantitative characteristics (distributed receptivity coefficients) are compared directly with those obtained in Blasius boundary layer. It is found that the adverse pressure gradient leads to reduction of efficiency of the vortex-roughness receptivity mechanism.

  4. Stability Analysis and Stabilization of T-S Fuzzy Delta Operator Systems with Time-Varying Delay via an Input-Output Approach

    Directory of Open Access Journals (Sweden)

    Zhixiong Zhong

    2013-01-01

    Full Text Available The stability analysis and stabilization of Takagi-Sugeno (T-S fuzzy delta operator systems with time-varying delay are investigated via an input-output approach. A model transformation method is employed to approximate the time-varying delay. The original system is transformed into a feedback interconnection form which has a forward subsystem with constant delays and a feedback one with uncertainties. By applying the scaled small gain (SSG theorem to deal with this new system, and based on a Lyapunov Krasovskii functional (LKF in delta operator domain, less conservative stability analysis and stabilization conditions are obtained. Numerical examples are provided to illustrate the advantages of the proposed method.

  5. Travelling TexTs alla Nordic Digital Humanities Conference: Riflessioni sulla situazione di Digital Humanities nell’ottica della storia letteraria finlandese

    Directory of Open Access Journals (Sweden)

    Viola Parente-Čapková

    2016-12-01

    Full Text Available In my contribution, I intend to offer a report on the first conference of Nordic Digital Humanities held in Oslo on March 15-17 2016. I begin with a brief note on the present situation of the discipline, and, following the arguments brought up during the conference, reflect on its existence, development and problems. Then I concentrate on the presentation of the HERA funded Joint Research Project Travelling TexTs 1790–1914: Transnational Reception of Women’s Writing at the Fringes of Europe (Finland, Norway, Slovenia, Spain, The Netherlands and the importance of the digital tool for the project work. I tackle the concept of distant and close reading and comment briefly on the possibilities which such projects offer in terms of new ways of writing and teaching (Finnish literary history.

  6. Comment on the Nanoparticle Conclusions in Crüts et al. (2008, "Exposure to diesel exhaust induces changes in EEG in human volunteers"

    Directory of Open Access Journals (Sweden)

    Long Christopher M

    2008-07-01

    Full Text Available Abstract A recent publication in this journal reported interesting changes in electroencephalographic (EEG waves that occurred in 10 young, male volunteers following inhalation for one hour of elevated levels of diesel-engine exhaust fumes 1. The authors then proposed a chain of causal events that they hypothesized underlay their observed EEG changes. Their reasoning linked the observed results to nanoparticles in diesel-engine exhaust (DEE, and went on to suggest that associations between changes in ambient particulate matter (PM levels and changes in health statistics might be due to the effects of diesel-engine exhaust (DEE nanoparticles on EEG. We suggest that the extrapolations of the Crüts et al. EEG findings to casual mechanisms about how ambient levels of DEE particulate might affect electrical signals in the brain, and subsequently to how DEE particulate might alter disease risk, are premature.

  7. Empaques alimenticios tipo film: estudio de mercado y determinación del costo relativo en el producto final

    OpenAIRE

    Proaño, Soraya

    2002-01-01

    La presente tesis tiene como propósito determinar el volumen del mercado de empaques alimenticios tipo film y sus características. Además determinar la incidencia del empaque tipo film en el costo total del producto. Para esto, primero se realiza una descripción general de los empaques, sus funciones y clasificación; se enfatiza en las características y aplicaciones de los empaques tipo film, lámina o película, así como su selección y su uso como herramienta de marketing. ...

  8. Desenvolvimento de um Produto para Determinação do Tipo Sanguíneo de Humanos

    OpenAIRE

    Bezerra, Karolina

    2016-01-01

    Esta dissertação relata o desenvolvimento de um produto para determinação do tipo san-guíneo de humanos. A necessidade de criar um produto eficiente e capaz de determinar o tipo sanguíneo em situações de emergências surge da possibilidade das análises serem realizadas em momentos críticos, onde se pretende eliminar o erro humano e minimizar os riscos de incompatibi-lidade nas transfusões sanguíneas. A proposta pretende resolver problemas dos procedimentos realizados na análise do tipo sang...

  9. CRESCIMENTO INICIAL DE GENÓTIPOS DE PINHÃO MANSO REPRODUZIDOS ASSEXUADAMENTE

    Directory of Open Access Journals (Sweden)

    Amanda Macedo Facirolli

    2012-09-01

    Full Text Available Normal 0 21 false false false PT-BR X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Objetivou-se com este trabalho avaliar o crescimento inicial de genótipos de pinhão manso reproduzidos via propagação assexuada. O experimento constitui-se de dezoito tratamentos (dezoito genótipos de pinhão manso dispostos em blocos casualizados, com quatro repetições. Avaliou-se altura de planta, diâmetro de colmo, índice de pegamento, número de hastes, número de cachos, e índice de clorofila por planta. Houve significância da interação entre os genótipos, ao nível de 1% de probabilidade para todas as características avaliadas. Os genótipo 1, 4, e 17 mostraram-se superiores sobre os demais pois apresentaram maiores número de hastes e de cachos por planta, maior diâmetro do colmo, índice de pegamento e maior índice de clorofila, podendo ser apontados como genótipos promissores para futuros programas de melhoramento genéticos.

  10. Heraclitean logos and flux in T.S. Eliot’s Four Quartets: 'cosmic consciousness' and 'the still point of the turning world'

    Directory of Open Access Journals (Sweden)

    A. Wessels

    2001-08-01

    Full Text Available T.S. Eliot prefaces “Burnt Norton”, the first of his Four Quartets, with two quotations from the Greek philosopher, Heraclitus. By means of these epigrams, Eliot points us to the Heraclitean opposition and paradoxical interdependence between logos and flux as a paradigm in the poem, a paradigm that he uses for an investigation and articulation of a number of philosophical contemplations. In this paper, I discuss Eliot’s different configurations of the logos/flux paradigm in the poem, firstly to illuminate the relationship between temporality and eternity, secondly, to elaborate the relationship between God and humanity, and thirdly to express the relationship between structured art and chaotic experience. In each instance it is not only the opposition between the two elements that is important, but also the point of contact, the intersection. There is some evidence that Eliot’s depiction of this intersection as, for example, the “moment in and out of time”, is based on personal experience of a transcendent, mystical nature. His expression of this experience is also investigated by comparing it to similar experiences described by others, notably by a Canadian psychiatrist, Richard Maurice Bucke. A comparison of Bucke’s description in his evolutionist text of 1901 and Eliot’s poetic rendering reveals not only surprising similarities but also essential differences which highlights Eliot’s purely Christian interpretation in the face of Bucke’s more universalist approach. For T.S. Eliot, eternity or timelessness can only be accessed through the temporal experience of human consciousness, in fleeting moments of exaltation in daily life, in the charged, timeless configurations of art as an imitation of divine creation, and finally in Christ, who embodies the love of God and is for Eliot the ultimate transection of the temporal and eternal, the flux and the logos.

  11. Los ejemplares tipo de Cicadellinae y Gyponinae (Hemiptera: Auchenorrhyncha: Cicadellidae depositados en el Museo de La Plata, Argentina

    Directory of Open Access Journals (Sweden)

    Susana L. PARADELL

    2010-01-01

    Full Text Available En la presente contribución, se realizó un relevamiento de los ejemplares tipo de Cicadellidae, depositados en la colección de la División Entomología del Museo de La Plata (MLP. Fueron examinados y listados 86 ejemplares tipo pertenecientes a 32 especies: siete Cicadellinae y 25 Gyponinae, las que fueron descriptas por los siguientes autores: Berg, DeLong, DeLong & Freytag, DeLong & Martinson, Spångberg , Tesón y Young. Para cada ejemplar tipo se brinda información acerca del nombre específico, referencia bibliográfica, categoría de tipo y procedencia.

  12. Resistência de biótipos de arroz-vermelho aos herbicidas imazapyr + imazapic e alternativas de controle

    Directory of Open Access Journals (Sweden)

    Rafael Salles Rubin

    2014-10-01

    Full Text Available O uso intenso de herbicidas com o mesmo mecanismo de ação na cultura do arroz (Oryza sativa L. tem selecionado biótipos resistentes, como, por exemplo, o arroz-vermelho (planta daninha resistente aos herbicidas imidazolinonas. Por essa razão, este trabalho foi desenvolvido com o objetivo de avaliar a resistência de arroz-vermelho ao herbicida imazapyr + imazapic, na região sul do Rio Grande do Sul, e o controle do biótipo resistente de arroz-vermelho com os herbicidas alternativos clethodim e glyphosate. Foram realizados três experimentos, em delineamento casualizado, arranjados em esquema fatorial. No primeiro experimento, o fator A testou biótipos de arroz-vermelho [ORYSA 184 (resistente e ORYSA 188 (susceptível], o fator B comparou herbicidas (imazapyr + imazapic, clethodim e glyphosate e o fator C avaliou doses dos herbicidas (0; 0,5; 1; 2; 4; 8; 16 e 32 vezes a dose recomendada. No segundo, compararam-se biótipos de arroz-vermelho e doses do herbicida imazapyr + imazapic (0; 0,5; 1; 2; 4; 8; 16; 32 e 64 vezes a dose recomendada. No terceiro, testaram-se biótipos de arroz-vermelho e doses diferentes do herbicida imazapyr + imazapic para cada biótipo. O biótipo ORYSA 184 é resistente ao imazapyr + imazapic, quando aplicada a dose máxima de registro e estádio indicado. Os herbicidas clethodim e glyphosate, detentores de mecanismos de ação alternativos, controlam o biótipo resistente ORYSA 184 de arroz-vermelho.

  13. Temperatura de armazenamento e tipo de corte para melão minimamente processado

    Directory of Open Access Journals (Sweden)

    Arruda Maria Cecília de

    2003-01-01

    Full Text Available O presente trabalho teve como objetivo determinar a temperatura de armazenamento e o tipo de corte que proporciona melhor manutenção da qualidade de melões minimamente processados. Melões rendilhados, híbrido Bonus II, foram processados em câmara fria a 12ºC. Os frutos foram cortados manualmente em 8 fatias longitudinais. Em um dos tratamentos, as fatias foram divididas em pedaços de aproximadamente 3 cm de base e, no outro tratamento, foram utilizadas fatias inteiras. O produto minimamente processado foi acondicionado em embalagem rígida de politereftalato de etileno e armazenado a 3; 6 e 9ºC. O delineamento experimental foi inteiramente casualizado em esquema fatorial. Foram realizadas análises físico-químicas e sensoriais a cada 3 dias, por um período de 9 dias. A coloração e o teor de sólidos solúveis totais não foram afetados pelos tratamentos. O produto armazenado a 3ºC manteve maiores valores de firmeza, independentemente do tipo de corte. A aparência foi considerada boa até o 9º dia de armazenamento e o aroma, até o 6º dia, para melões a 3ºC. Em todos os tratamentos, houve declínio das notas atribuídas ao sabor durante o armazenamento. Pelos resultados obtidos, conclui-se que a qualidade de melões minimamente processados pode ser mantida por 6 dias a 3ºC, independentemente do tipo de corte.

  14. Financiarización del tipo de cambio en México y la actividad productiva

    Directory of Open Access Journals (Sweden)

    Antonio Mendoza Hernández

    2016-01-01

    Full Text Available Existe una estrecha relación entre el fortalecimiento del proceso de financiarización y la gestión de las diferentes monedas. Dicha relación aparece cuando en los espacios monetarios locales se abandona la demanda de moneda nacional en beneficio de alguna otra moneda o cualquier objeto especulativo. Se trata de una política económica a favor del beneficio financiero. En la gestión de las monedas locales, se impone la nueva norma de las altas finanzas: remuneración elevada, inflación escasa. El tipo de cambio en México está en función de las condiciones de confianza y rentabilidad del beneficio financiero. Las fluctuaciones en el tipo de cambio se convirtien en un factor determinante de las variaciones experimentadas por los flujos de tesorería, las ventas, los beneficios y los activos de las grandes empresas dedicadas a la actividad productiva cotizados en diversas monedas. Lo anterior se traduce en un atractivo para el capital monopolista ­financiero local, pues significa no sólo mantener su riqueza financiera y recibir íntegramente sus intereses, sino que también verse premiadas con un beneficio financiero, en su propia moneda. La certidumbre relativa sobre la evolución del tipo de cambio en la economía mexicana es una acción necesaria para que un sector importante de las grandes empresas relacionadas al capital – monopolista financiero mantenga sus condiciones de rentabilidad.

  15. Teor de amilose em genótipos de arroz Amylose contents in rice genotypes

    Directory of Open Access Journals (Sweden)

    Dayse Soave

    1995-01-01

    Full Text Available Caracterizou-se o teor de amilose em grãos de arroz de sequeiro, divididos em 16 genótipos de ciclo precoce e 16 de ciclo tardio, com base em linhagens e cultivares do programa de melhoramento do Instituto Agronômico, colhidos de ensaios desenvolvidos no Centro Experimental de Campinas e na Estação Experimental de Votuporanga. Os teores de amilose variaram de 16,2 a 29,3%, com predominância de teores intermediários (20 a 25%. Um genótipo mostrou teor baixo (menor que 20%; dez, teores intermediários; quatro, teores altos (maior que 25% de amilose, em ambas as localidades, e os 17 restantes apresentaram comportamento variável nos dois ambientes. Os dados demonstram que o teor de amilose é influenciado pelo genótipo, pelo local de plantio e pela interação entre essas variáveis.The amylose content of rice grains from 16 early and 16 late mature groups of varieties and advanced lines from Instituto Agronômico rice breeding program was studied. The experiments were grown and harvested under two different environments: Campinas Experimental Center and Votuporanga Experimental Station, State of São Paulo, Brazil. Amylose content ranged from 16.2% to 29.3%, but intermediate contents (20-25% predominated. One genotype showed low (25% amylose content in both environments, whereas 17 other varied in amylose content in the two environments studied. Data obtained showed that amylose content is influenced by genotype, environment and the interaction of these two variables.

  16. El coste de la diabetes tipo 2 en España: El estudio CODE-2

    Directory of Open Access Journals (Sweden)

    Mata M.

    2002-01-01

    Full Text Available Objetivo: Estimar el coste de la atención sanitaria al paciente diabético tipo 2, diferenciando el gasto derivado del control de la enfermedad, de la atención de sus complicaciones y de otros costes directos asociados. Métodos: Recogida retrospectiva del consumo de recursos a partir de la historia clínica y la entrevista personal en 29 centros de atención primaria de todo el territorio nacional de una muestra de pacientes seleccionados de forma aleatoria a partir del registro de diabéticos de cada centro. Resultados: Se evaluó a 1.004 pacientes (561 mujeres con una media de edad de 67,42 años y una media de evolución de la enfermedad de 10,07 años. El 50,9% no presentaba complicaciones, el 17,7% sólo macrovasculares, el 19,5% sólo microvasculares y el 11,9% ambas. El coste anual sanitario por paciente fue de 1.305,15 euros. De este coste el 28,6% (373,27 euros estaba relacionado directamente con el control de la diabetes, el 30,51% (398,20 euros con sus complicaciones y el 40,89% (533,68 euros no estaba relacionado. El coste medio de un paciente sin complicaciones fue de 883 euros frente a 1.403 de un paciente con complicaciones microvasculares, 2.022 cuando existían complicaciones macrovasculares y 2.133 cuando coexistían ambos tipos de complicaciones. Conclusiones: El elevado coste del tratamiento de la diabetes tipo 2 y sus complicaciones, sugiere la posibilidad de que la mejora del control de la enfermedad pueda no sólo mejorar la supervivencia y la calidad de vida, sino reducir los costes asociados con las complicaciones crónicas.

  17. Pipe type poles in transmission power lines; Postes tipo tubo en lineas de transmision

    Energy Technology Data Exchange (ETDEWEB)

    Cervantes E, Mario; Becerril A, Armando [Luz y Fuerza del Centro, Mexico, D. F. (Mexico)

    1997-12-31

    The first supports for transmission power lines were relatively small structures, of simple configuration, to save reduced clearances to resist load in accordance with its need; with the technical development, gradually appeared higher and higher electric tensions and greater obstacles to overcome, consequently the design of the supports had to be adapted to the new conditions. This gave rise to the development of a specific technique that would adequate and incorporate the continuous engineering advances. In this document the initial considerations on the design poles pipe type are examined; within these considerations mention is made of: the design, the manufacture, the prototype tests, installation, quality control and foundations. The type tube pole is portrayed, as well as the steel reinforcement, finally the types of precast foundations are shown [Espanol] Los primeros soportes para lineas de transmision fueron estructuras relativamente pequenas, de configuracion simple, para salvar claros reducidos y resistir cargas proporcionales a sus necesidades, con el desarrollo de la tecnica, fueron apareciendo tensiones electricas cada vez mas elevadas y obstaculos mayores que vencer, por lo que el diseno de los soportes tuvo que adaptarse a las nuevas condiciones. Esto dio origen al desenvolvimiento de una tecnica especifica que fuese adecuando e incorporando los continuos avances de la ingenieria. En este documento se tratan las consideraciones iniciales del diseno de los postes tipo tubo; dentro de estas consideraciones se citan: el diseno, la fabricacion, las pruebas de prototipo, montajes, control de calidad y cimentaciones. Se ilustra el poste tipo tubo, al igual que el armado del poste, por ultimo se muestra los tipos de cimentaciones precoladas

  18. Efecto de dos tipos de raciones y cuatro alojamientos sobre el comportamiento productivo de cerdas gestantes

    OpenAIRE

    H. Araque; C. González; A. Fuentes; L. Sulbarán; F. Mora

    2012-01-01

    El experimento se realizó en la Facultad de Agronomía, Universidad Central de Venezuela, con el objeto de evaluar el comportamiento productivo de cerdas que recibieron dos tipos de dietas y se alojaron durante la fase de gestación en cuatro sistemas diferentes de alojamiento. Las dietas fueron: con base de recursos tradicionales (dt) y formulada con recursos alternativos (ra: raíz de yuca, follaje de yuca y morera, y aceite de palma). Los sistemas de alojamiento fueron: cama profunda (cp), ca...

  19. Los modelos de equilibrio general estocástico y el tipo de cambio

    OpenAIRE

    Jiménez Martín, Juan Ángel

    2003-01-01

    Una parte muy importante de la investigación en economía financiera inernacional se ha dedicado a explicar el comportamiento del tipo de cambio. A partir de los años 80, Lucas (1978,1982), Helpman y Razin (1979,1982) y Stockman (1980,1983,1987) implementan los modelos de equilibrio dinámicos como herramienta para analizar teóricamente algunos de los problemas más relevantes que se estaban produciendo en los mercados de divisas, sobre todo, los relacionados con los posibles efectos de la polít...

  20. La sítula de Caesaraugusta-Zaragoza y los apliques tipo III de Delgado

    Directory of Open Access Journals (Sweden)

    Erice Lacabe, Romana

    2006-12-01

    Full Text Available This paper deals with a bronze situla from Caesaraugusta- Zaragoza, which has preserved its handles decorated with male masks type III from Delgado. It is made here the first classification of this group of situlae, until now not well known.Se da a conocer el hallazgo de una sítula completa de Zaragoza que conserva los apliques figurados, unas máscaras masculinas correspondientes al tipo III de Delgado, grupo tipológico poco conocido del que se presenta un primer estudio.

  1. Análise do cariótipo de Apuleia leiocarpa (Vog.) Macbr.

    OpenAIRE

    Auler,Neiva Maria Frizon; Battistin,Alice

    1999-01-01

    Estudos citogenéticos da Apuleia leiocarpa foram realizados com o objetivo de determinar e montar o cariótipo da espécie. As sementes utilizadas foram coletadas na localidade de Cerrito, município de Santa Maria - RS. A pesquisa foi conduzida no Laboratório de Citogenética Vegetal e Biotecnologia do Departamento de Biologia da Universidade federal de Santa Maria - RS, nos anos de 1996 - 1997. Em metáfases de mitose foi encontrada uma variação no número de cromossomos de 20 a 28, sugerindo ser...

  2. Estado nutricional del lactante de uno a seis meses y tipo de lactancia.

    OpenAIRE

    Ubillus, Gloria; Lamas, Cristina; Lescano, Beatriz; Levano, Melissa; Llerena, Zoila; Lopez, Rosa

    2011-01-01

    OBJETIVOIdentificar el estado nutricional de lactantes de uno a seis meses que acuden a consultorio externo en relación el tipo de lactancia..MATERIAL Y MÉTODOSe realizó un estudio observacional, descriptivo en el Instituto Nacional de Salud del Niño, centro de referencia nacional, entre Septiembre- Noviembre del 2007. Se seleccionó aleatoriamente 250 niños entre 1-6 meses de edad de ambos géneros, para ser estudiados en consultorios externos. Se evaluó las medidas de talla, peso y perímetro ...

  3. O estereótipo da bruxa nos contos populares e nos contos infantis

    OpenAIRE

    Gonçalves, Carla Alexandra Esteves

    2011-01-01

    Efectuámos uma análise do perfil da personagem da bruxa em contos populares e contos infantis, com o intuito de relacionar o seu estereótipo num contexto narrativo diferente. Para tal, efectuámos um estudo exaustivo, comparando a bruxa nos níveis linguístico, retórico, narrativo, axiológico e semiótico-contextual. Para investigar esta personagem seleccionaram-se contos da literatura de tradição oral e contos infantis, na sua versão escrita, onde a bruxa se movimentava. Analisámos, numa pri...

  4. Estudio de la respuesta autoreactiva de linfocitos B anti-periferina en la diabetes tipo I

    OpenAIRE

    Garabatos Leitón, Mª Nahir

    2014-01-01

    [spa] La diabetes tipo 1 (DT1) es una enfermedad de origen multifactorial, caracterizada por la destrucción selectiva de células ß productoras de insulina localizadas en los islotes pancreáticos. Estudios realizados en el modelo de ratón NOD, han revelado que la respuesta autoinmune en esta enfermedad está dirigida principalmente por poblaciones autoreactivas de linfocitos T CD4 y CD8 infiltrantes de islote. Durante muchos años, el papel de los linfocitos B en la DT1 ha sido relegado a un ...

  5. Tamizaje de Diabetes Mellitus tipo 2 en atención primaria

    OpenAIRE

    Adriana Laclé; Carmen Peralta

    2006-01-01

    artículo -- Universidad de Costa Rica, Instituto de Investigaciones en Salud. 2006 Introducción: Actualmente en Costa Rica debería considerarse la Diabetes Mellitus tipo 2, un problema de salud pública, por el impacto de sus complicaciones crónicas tanto en el ámbito individual y familiar, como en lo económico, en la escala nacional. Su detección y tratamiento temprano ha demostrado que reduce la carga de sus complicaciones, por lo que su tamizaje podría ser oportuno en personas que tengan...

  6. Clustering e switching na fluência verbal infantil: idade, tipo de escola e TDAH

    OpenAIRE

    Gonçalves, Hosana Alves

    2015-01-01

    A neuropsicologia infantil tem crescido no Brasil com a publicação de instrumentos adaptados e normatizados para este público, além da elaboração de programas e de ações de intervenção tanto para o âmbito clínico quanto escolar. No entanto, predominam, ainda, análises quantitativas mais gerais e tradicionais, principalmente com escores totais de acertos. Assim, o objetivo desta dissertação foi verificar a influência da idade, do tipo de escola e do TDAH no processamento de clustering e switch...

  7. Variación de la actividad cognitiva en diferentes tipos de pruebas de fluidez verbal.

    OpenAIRE

    Julián C. Marino; Ana M. Alderete

    2009-01-01

    En esta investigación se aplicaron diez pruebas de fluidez verbal del tipo fonológico, categorial, gramatical y combinadas a 259 adultos argentinos (15 a 70 años) con el fin de conocer su correlación con la actividad ejecutiva, semántica y atencional. Se indagó sobre la estructura teórica de cada prueba de fluidez verbal, a fines de determinar la lógica de sus variaciones. El objetivo final de la investigación fue aportar al desarrollo de un explorador neuropsicológico en fluidez verbal, que ...

  8. Tipos de descortesía verbal y emociones en contextos de cultura hispanohablante

    Directory of Open Access Journals (Sweden)

    de Marlangeon Silvia Kaul

    2017-07-01

    Full Text Available El presente estudio, de carácter interpretativo-descriptivo, se ocupa de la relación existente entre el lenguaje verbal, la descortesía y las emociones en contextos de cultura hispanohablante. Se investiga dicha relación para algunos tipos de actos descorteses, correspondientes a tipos de una escala de intensificación de la fuerza de descortesía (Kaul de Marlangeon. 2008, Tipología del comportamiento verbal descortés en español. En A. Briz- Gómez, A. Hidalgo-Navarro, M. Albelda Marco, J. Contreras y N. Hernández Flores (Eds., Cortesía y conversación: de lo escrito a lo oral. Tercer Coloquio Internacional del Programa EDICE, Vol. 3 (pp. 254–266. Valencia/Estocolmo: Universidad de Valencia- Programa EDICE, Kaul de Marlangeon y Alba-Juez. 2012, A typology of verbal impoliteness behaviour for the English and Spanish Cultures. Revista Española de Lingüística Aplicada (RESLA 25, pp. 69–92, y la consiguiente construcción discursiva de las emociones presentes en ellos. A tal fin, se adopta el punto de vista sociocultural de la pragmática, necesario tanto para el análisis del discurso de (descortesía como para el de las emociones intervinientes en los distintos tipos de actos de descortesía, éstos y aquéllas asociados a sus respectivos contextos socioculturales y situacionales. De igual forma, se acoge el punto de vista de la psicología social, especialmente aquél que pone el énfasis en la dependencia contextual de las emociones y las considera como una construcción social. El pertinente corpus de ejemplos ha sido recogido en diferentes contextos de cultura hispanohablante (argentinos, chilenos, españoles, mexicanos, venezolanos, uruguayos que validan una interpretación ingtercultural. Los resultados de la descripción émica muestran que en cada tipo de descortesía considerado concurren complejas experiencias emocionales, sobre todo negativas, activadoras de conductas agresivas y de su grado de intensidad o de

  9. QUALIDADE NUTRICIONAL E ANTIOXIDANTE DO TOMATE “TIPO ITALIANO”

    Directory of Open Access Journals (Sweden)

    C. S. MONTEIRO

    2008-12-01

    Full Text Available

    O tomate híbrido tipo italiano (saladete Lycopersicon esculentum Mill, apresenta baixa caloria, é rico em vitaminas (A e C, sódio, potássio, cálcio, fósforo e ferro. Alguns parâmetros de qualidade são empregados na análise da composição: acidez; sólidos solúveis; teor de açúcar e licopeno; aparência; textura; sabor; tamanho e suculência. O presente trabalho teve como objetivo conhecer a quantidade de compostos fenólicos, composição química do tomate tipo italiano e determinar a atividade antioxidante. Os resultados, em base seca, de tomate tipo italiano sem casca e sem semente e de tomate com casca e com semente apresentaram baixos teores de proteína (2,16%, lipídio (0,26%, fi bra (0,28% e umidade (85,09%. O valor de SST encontrado no tomate sem semente e sem casca e no tomate com semente e com casca foi menor do que encontrado na literatura. O peso unitário médio dos tomates ficou com 101,05g; de diâmetro longitudinal 55,136mm e 81,164mm de diâmetro transversal. A atividade antioxidante no molho está relacionada à concentração de compostos fenólicos. Novos estudos sobre o tomate tipo italiano Lycopersicon esculentum Mill poderão corroborar essas informações, principalmente para efeitos comparativos, visando à padronização de dados da composição química.

  10. Autopsia verbal en hombres adultos con diabetes tipo 2: estudio cualitativo

    OpenAIRE

    Geu Mendoza-Catalán; Esther C. Gallegos-Cabriales; Juan Guillermo Figueroa-Perea

    2017-01-01

    Introducción: La diabetes mellitus tipo 2 (DMT2) es un padecimiento crónico cuya incidencia se incrementa en forma alarmante. El objetivo fue identificar los factores asociados al no autocuidado en hombres con muerte prematura y diagnóstico de DMT2. Materiales y Métodos: Se realizaron seis entrevistas cualitativas a familiares de hombres con DMT2 que fallecieron por complicaciones de su enfermedad, utilizando la metodología de la autopsia verbal. Los resultados se analizaron mediante el análi...

  11. Estilo de vida actual de los pacientes con diabetes mellitus tipo 2

    OpenAIRE

    María Mercedes Ramírez-Ordoñez; Maira Ascanio-Carvajalino; Mariana del Pilar Coronado-Cote; Carlos Alberto Gómez-Mora; Luz Dary Mayorga-Ayala; Rosalvis Medina-Ospino

    2011-01-01

    Se realizó un estudio descriptivo transversal con el objetivo principal de determinar el estilo de vida actual de los pacientes con diabetes mellitus tipo 2. Para la recolección de la información se utilizó el cuestionario IMEVID1. La población está conformada por 60 pacientes inscritos al programa de diabetes e hipertensión de una Institución Promotora de Salud (IPS) de I nivel; como muestra se tuvo en cuenta 30 pacientes que asistieron sin falta al control de la diabetes a los cuales se les...

  12. ASPECTOS HIGIÊNICO-SANITÁRIOS DE ESTABELECIMENTO COMERCIAL DO TIPO SUPERMERCADO DE GRANDE PORTE.

    OpenAIRE

    Pedroso, Kátia Rejane Pereira de Queiroga; Bernardino, Priscilla Diniz Lima da Silva

    2016-01-01

    RESUMOOs supermercados são locais aonde o consumidor pode encontrar vários produtos indispensáveis ao seu dia-a-dia, principalmente os produtos alimentícios. Este tipo de comércio deve oferecer um serviço de qualidade capaz de assegurar a saúde do consumidor, por meio dos preceitos higiênico- sanitários, conforme a legislação vigente determina. Objetivou-se neste trabalho a avaliação da qualidade dos serviços oferecidos ao consumidor por três supermercados da rede Y, em Cascavel, PR. A metodo...

  13. Alteraciones electrocardiográficas y factores de riesgo cardiovascular en pacientes con diabetes tipo 2

    Directory of Open Access Journals (Sweden)

    Rodríguez-Morán Martha

    1999-01-01

    Full Text Available Objetivo. Determinar cuáles son las alteraciones del ritmo y la conducción cardiaca más frecuentes en pacientes con diabetes tipo 2 sin cardiopatía previa y establecer su asociación con los factores de riesgo cardiovascular. Material y métodos. Se incluyeron pacientes con diabetes tipo 2 sin presencia o antecedentes de cardiopatía. Se determinaron los factores de riesgo cardiovascular, el índice de masa corporal y los niveles séricos de glucosa, colesterol y triglicéridos. Se registró electrocardiograma convencional en reposo. La asociación de las variables en estudio con la ocurrencia de arritmias se calculó con un modelo de análisis multivariado ajustado por sexo. Resultados. Se integraron 199 pacientes: 113 mujeres (56.8% y 86 hombres (43.2%, y se identificó algún tipo de alteración electrocardiográfica en 29.1% de los sujetos. El hemibloqueo fascicular anterior (HFA y el bloqueo completo de rama derecha del Haz de His (BRDHH, constituyeron 75.9% de las alteraciones identificadas. Los pacientes con trastornos del ritmo y la conducción tienen niveles más elevados de colesterol y triglicéridos. La aparición de arritmias se relaciona directamente con el incremento de la edad (r= 0.75, p= 0.01. En el análisis multivariado ajustado por sexo la hipercolesterolemia y la edad se asociaron significativamente con las alteraciones del ritmo y la conducción: RM 1.5, IC95% 1.1-4.6, p< 0.05 y RM 1.3, IC95% 1.0-5.2, p< 0.05, respectivamente. Conclusiones. Las alteraciones del ritmo y la conducción cardiaca más frecuentes en la diabetes tipo 2 son el HFA y el BRDHH; la hipercolesterolemia y la edad son los factores asociados a su presencia.

  14. Relaciones entre el Desarrollo de Gratitud y Tipos de Valores en Jóvenes

    OpenAIRE

    Freitas, Lia Beatriz de Lucca; Tudge, Jonathan Richard Henry; Palhares, Fernanda; Prestes, Andressa Carvalho

    2016-01-01

    Resumo Investigam-se relações entre o desenvolvimento da gratidão e tipos de valores. Trezentos e noventa e seis jovens de 7 a 14 anos responderam a Wishes and Gratitude Survey. Previu-se que, com o aumento da idade, haveria (a) uma diminuição de valores hedonistas; (b) uma diminuição de gratidão concreta e um aumento de gratidão conectiva. A terceira hipótese foi a de que seria mais provável que jovens com valores hedonistas expressassem gratidão concreta e aqueles com valores relacionados a...

  15. Tratamento da hipertensão arterial nos doentes com diabetes mellitus tipo 2

    OpenAIRE

    Jorge, Luís Carlos Marques Viana

    2010-01-01

    1 INTRODUÇÃO A Hipertensão Arterial (HTA) e a Diabetes Mellitus (DM), particularmente a Diabetes Mellitus tipo 2 (DM2), são entidades clínicas que frequentemente se associam e que exercem um efeito sinérgico, aumentando o risco cardiovascular e facilitando a deterioração da função renal. 1.2 OBJECTIVO Fazer uma revisão da literatura sobre o tratamento da HTA nos doentes com DM2, procurando estabelecer uma visão actualizada sobre o tema, designadamente analisar as class...

  16. Prototipo de robot de rehabilitación de mano tipo “agarre terminal”

    OpenAIRE

    Blanco Lahuerta, José Luis

    2017-01-01

    En este proyecto se realiza el diseño, la fabricación del primer prototipo y un primer control básico de un robot de rehabilitación de mano, tipo agarre terminal. Su posible uso se enmarca en el ámbito de la ayuda en la rehabilitación de pacientes con deficiencias neuromotoras tras haber sufrido un ataque cerebrovascular (ictus), principalmente para tratar problemas de espasticidad. Este proyecto tiene una parte de diseño mecánico y una parte de diseño de software. Depart...

  17. RADIOEMISSÕES SOLARES TIPO II ASSOCIADAS A FLARES E CMES

    Directory of Open Access Journals (Sweden)

    Rafael Douglas Cunha-Silva

    2013-12-01

    Full Text Available Atribuídas a ondas de choque e a ejeções de plasmoide, as emissões solares tipo II são ondaseletromagnéticas geradas a partir de oscilações do plasma coronal. A origem dos choques associados a essasemissões é ainda uma questão em aberto da física solar. Enquanto alguns trabalhos sugerem os flares solarescomo seus acionadores, outros fornecem indícios de serem as ejeções de massa coronal (CMEs sua origemmais provável. Este trabalho apresenta os resultados da análise de duas emissões tipo II, registradas por doisespectrômetros da rede e-CALLISTO (extended-Compound Astronomical Low-cost Low-frequency Instrument forSpectroscopy and Transportable Observatory, os quais operam na faixa de frequências de 45-870 MHz. Oprimeiro evento, observado em 13 de junho de 2010, às 05:38 UT, apresentou uma taxa de deriva em frequênciade -0,2 MHz s-1, correspondente a uma velocidade de choque de 528 km s-1, estando, temporalmente, associadoa uma CME lenta (~320 km s-1 e a um flare solar em raios-X, classe M1.0. O segundo evento, observado em 09de Agosto de 2011, às 08:02 UT, apresentou uma taxa de deriva em frequência de -1,4 MHz s-1, correspondentea uma velocidade de choque de 1375 km s-1, estando, temporalmente, associado a uma CME tipo halo (~1610km s-1 e a um flare solar em raios-X, classe X6.9. Os resultados obtidos, para os parâmetros observacionais dasemissões tipo II e para os parâmetros físicos de suas fontes, são discutidos no contexto de sua relação com seuflares e CMEs associados.

  18. Diabetes tipo 2 en niños: Reporte de caso

    OpenAIRE

    Miguel Pinto; Segundo Seclén; Emilio Cabello

    2010-01-01

    Se reporta el caso de una niña de 14 años con antecedentes de obesidad, dislipidemia y diabetes que es referida a nuestro servicio por polidipsia, poliuria y sobrepeso. La paciente tenía el antecedente familiar de ambos padres con diagnóstico de diabetes tipo 2. El examen físico mostró obesidad central y acantosis nigricans severa en los pliegues cutáneos. Los análisis de laboratorio mostraron hiperglicemia, hiperinsulinemia y pép...

  19. Lipodistrofia parcial familiar tipo 1: ¿Un síndrome subdiagnosticado o raro?

    OpenAIRE

    Jimena Soutelo; Mariana Grüneisen; Clara Fritz; Laura Sordo; Yanina Powazniak; Rubén Lutfi

    2015-01-01

    La lipodistrofia parcial familiar de tipo1 (LPF 1) es un síndrome caracterizado por la pérdida parcial de grasa subcutánea en extremidades con distribución incrementada de la misma en rostro, cuello y tronco. Es una identidad familiar aunque hay casos espontáneos. Hasta ahora no se conoce mutación responsable. Se debe realizar diagnóstico diferencial con el síndrome de Cushing. Es un síndrome poco frecuente y en oportunidades se llega al diagnóstico cuando los pacientes presentan complicacion...

  20. Tipos de cambio fijos e intervención en el Mercado de Divisas

    OpenAIRE

    Gómez-Puig, Marta

    2006-01-01

    Este artículo revisa el trilema de las economías abiertas: mantenimiento simultáneo de tipos de cambio fijos, libertad de movimiento de capitales y autonomía monetaria. A partir de la citada revisión, se hace un análisis exhaustivo de los diferentes regímenes cambiarios existentes según la clasificación del Fondo Monetario Internacional, se analizan las principales ventajas e inconvenientes ligados a los distintos regímenes, y se concluye señalando que ni existe un sistema cambiario perfecto,...

  1. PROPUESTA DE REFORZAMIENTO PARA EDIFICACIÓN EDUCATIVA TIPO ANTIGUOII-MOP VENEZUELA

    OpenAIRE

    J. Yépez; M. Y. Dikdan; L. Andrade; R. Rojas

    2016-01-01

    Se presenta en este artículo el estudio de reforzamiento estructural para una edificación de uso educativo, conocida como “Tipo Antiguo II”. La escuela fue construida antes de la creación de la Norma Venezolana Sismorresistente Covenin 1756. Los resultados del análisis estructural demostraron insuficiente capacidad de respuesta ante las solicitaciones de servicio, alta vulnerabilidad ante la acción sísmica y deficiencias en la cantidad y distribución del acero de refuerzo. Por tal motivo se p...

  2. Estudo comparativo de diferentes tipos de polibutadieno na tenacificação de poliestireno

    OpenAIRE

    Coutinho,Fernanda M. B.; Costa,Marcia P. M.; Guimarães,Maria José O. C.; Soares,Bluma G.

    2007-01-01

    Neste trabalho foi avaliada a tenacificação de poliestireno (PS) utilizando três tipos de polibutadieno (PB): polibutadieno baixo-cis (PBb), polibutadieno alto-cis (PBa) e copolímero em bloco (SBS) de estireno e butadieno (PBco). Foi observado um aumento na resistência ao impacto de 138, 208 e 823%, quando foram utilizados polibutadieno baixo-cis, polibutadieno alto-cis e copolímero em bloco de estireno e butadieno respectivamente. Os materiais apresentaram morfologia dispersa com domínios de...

  3. Opacificação tipo "snowflake" em lente intra-ocular de polimetilmetacrilato (PMMA)

    OpenAIRE

    Pereira,Fabiana Dalla Rosa; Lima,Vagner Loduca; Rehder,José Ricardo Carvalho Lima

    2011-01-01

    As lentes intraoculares têm sido utilizadas na reabilitação de pacientes submetidos à cirurgia de catarata desde 1959 com grande sucesso. Entretanto, alterações no biomaterial dessas lentes vêm sendo descritas nos últimos anos, diminuindo a acuidade visual dos pacientes anos depois da cirurgia. Este relato apresenta um caso de opacificação tipo "snowflake" em lente de polimetilmetacrilato, seguida de discussão sobre as principais características dessa alteração e indicação de retirada e troca...

  4. Opacificação tipo "snowflake" em lente intra-ocular de polimetilmetacrilato (PMMA

    Directory of Open Access Journals (Sweden)

    Fabiana Dalla Rosa Pereira

    2011-04-01

    Full Text Available As lentes intraoculares têm sido utilizadas na reabilitação de pacientes submetidos à cirurgia de catarata desde 1959 com grande sucesso. Entretanto, alterações no biomaterial dessas lentes vêm sendo descritas nos últimos anos, diminuindo a acuidade visual dos pacientes anos depois da cirurgia. Este relato apresenta um caso de opacificação tipo "snowflake" em lente de polimetilmetacrilato, seguida de discussão sobre as principais características dessa alteração e indicação de retirada e troca da lente intraocular.

  5. Adolescentes com Diabetes mellitus tipo 1: seu cotidiano e enfrentamento da doença

    OpenAIRE

    Santos, Jocimara Ribeiro dos; Enumo, Sônia Regina Fiorim

    2003-01-01

    Diabetes mellitus Tipo 1 é uma doença crônica com incidência de 2/1000 adolescentes, que podem ter seu cotidiano alterado. Visando a descrever e analisar como esses adolescentes organizam suas atividades diárias e enfrentam a condição de apresentarem uma doença crônica, foram entrevistados 15 adolescentes que freqüentavam programas de saúde pública para portadores de diabetes em Vitória, ES, que responderam também ao Mapeamento de Atividades Cotidianas-MAC. Este questionário foi aplicado tamb...

  6. FITOQUÍMICOS BIOATIVOS EM FRUTOS DE GENÓTIPOS DE CAJÁ-UMBUZEIRAS

    Directory of Open Access Journals (Sweden)

    Aldenise Chagas Curvêlo Gonçalves MOREIRA

    2012-04-01

    Full Text Available Com o objetivo de quantificar os fitoquímicos bioativos em cajá-umbu foram utilizadas polpas de frutos de 4 genótipos (G 2.2, G 2.3, G 3.1 e G 3.2 procedentes do Banco de Germoplasma do Instituto Agronômico de Pernambuco (IPA. Os teores de fenólicos, flavonoides e flavonóis totais e taninos condensados foram quantificados por método espectrofotométrico, de ácido ascórbico por método titulométrico e de carotenoides por método cromatográfico e espectrofotométrico. Os genótipos apresentaram teores de fenólicos totais de 110,61 a 188,86mg equivalente em ácido gálico 100g-1, flavonoides de 1,95 a 2,37mg em equivalente de catequina 100g-1, flavonóis de 2,59 a 2,80mg em equivalente de quercetina 100g-1 e taninos condensados de 42,77 a 48,24mg em equivalente de catequina 100g-1. Os frutos apresentaram baixos teores de ácido ascórbico (6,1 a 7,3mg 100g-1 e de carotenoides (6,67 a 11,44μg g-1. O β-caroteno-5,6-5’6’-diepóxido foi o componente majoritário dos genótipos G 2.2, G 2.3 e G 3.1, enquanto que a luteína-5,6 epóxido foi encontrada em maior quantidade no G 3.2. Assim, embora os frutos dos genótipos tenham exibido variações nos teores dos fitoquí- micos bioativos, apresentam em sua constituição quantidades relevantes destes compostos, podendo contribuir com o aporte de antioxidante dietético.

  7. Presencia de afecciones oftalmológicas en pacientes con diabetes mellitus tipo 2

    OpenAIRE

    Bárbara Suárez Rodríguez; María Adela Llull Tombo; Mariela Julia Curbelo Gómez; Leonor Díaz Alfonso; Anay Martínez Díaz

    2011-01-01

    Fundamento: la diabetes mellitus es un importante problema de salud a nivel mundial, por ser una de las afecciones no transmisibles más frecuentes, así como por la severidad y diversidad de sus complicaciones crónicas, que incluyen al órgano de la visión. Objetivo: identificar la presencia de afecciones oftalmológicas en pacientes con diabetes mellitus tipo 2. Métodos: estudio descriptivo de serie de casos realizado en el Centro de Atención y Educación al Diabético, de Cienfuegos, en el perío...

  8. SOBREPESO Y OBESIDAD DEL LACTANTE EN RELACIÓN AL TIPO DE LACTANCIA RECIBIDA

    OpenAIRE

    Cherrez Aguilar, Rodrigo

    2016-01-01

    El sobrepeso y la obesidad infantil están asumiendo ahora proporciones epidémicas en muchas partes del mundo, observándose además que la prevalencia aumenta en los países de ingresos bajos y moderados como en Ecuador. Con el objetivo de identificar la influencia que tiene el tipo de lactancia recibida, sobre el peso de los lactantes menores de 12 meses, se realizó una investigación Descriptiva transversal. Se calcularon porcentajes y tasas de prevalencias, empleamos la prueb...

  9. Cocción de alimentos en Bogotá empleando una cocina solar tipo caja

    OpenAIRE

    Silvio Alejandro Jiménez Castellanos; Luis Carlos Rátiva Prieto

    2015-01-01

    Este artículo tiene como objetivo presentar el campo transitorio de temperaturas de una cocina solar tipo caja básica (sin aditamentos tales como: doble acristalamiento, reflectores internos, reflectores externos, línea de alivio de vapor, entre otros); diseñada para las condiciones meteorológicas promedio anuales de Bogotá – Colombia, con el fin de determinar sí con este dispositivo es posible cocinar en esta ciudad. La metodología utilizada comprendió tres fases: el desarrollo de un modelo ...

  10. Régimen con insulina lispro mix 25 versus insulina glargina para la diabetes tipo 2

    OpenAIRE

    Laura Fernández Landó; Fabio Massari; Alejandra Oviedo; Honghua Jiang

    2012-01-01

    La información sobre el inicio de regímenes de insulina en poblaciones específicas con diabetes tipo 2 (DT2) es limitada. Se comparó eficacia y seguridad de dos regímenes de inicio: insulina lispro mix 25 (LM25) e insulina glargina basal (GL). Se evaluaron 193 pacientes no tratados previamente con insulina, en la fase de iniciación de 24 semanas del ensayo DURABLE; edades: 30-79 años, DT2 controlada inadecuadamente (HbA1c > 7.0%) con = 2 medicaciones orales antidiabéticas (MOAs), aleatorizado...

  11. Road accidents at night in the Netherlands : a national analysis according to official road accident data. Contribution to OECD Research Group TS 3 on Improving Road Safety at Night.

    NARCIS (Netherlands)

    Harris, S.

    1979-01-01

    The questionnaire about night-time accident data of the OECD Research Group TS 3 on Improving Road Safety at Night was filled in for the Netherlands. Thereafter a national analysis was written, using the already completed accident data questionnaire. Guidelines for the contents and presentation

  12. O MARKETING SOCIAL COMO DIFERENCIAL COMPETITIVO: O CASO DA EMPRESA EXPRESSO GUANABARA

    OpenAIRE

    Patrícia Grenfell Oliveira; Renata Aquino Ribeiro; Augusto C. Aquino Cabral; Sandra Maria Santos

    2015-01-01

    Nos últimos anos as organizações têm demonstrado grande preocupação com as questões sociais e os conflitos ambientais que cercam nossa sociedade. Neste contexto surge o conceito de responsabilidade social e o marketing social, como um campo de atuação inspirado na ideia de sustentabilidade, capaz de alavancar a imagem e a marca da organização, além de ser uma diferencial perante seus concorrentes. Desta forma, a presente pesquisa teve como principal objetivo verificar a percepção dos clientes...

  13. Utilization of a ts-sacB selection system for the generation of a Mycobacterium avium serovar-8 specific glycopeptidolipid allelic exchange mutant

    Science.gov (United States)

    Irani, Vida R; Lee, Sun-Hwa; Eckstein, Torsten M; Inamine, Julia M; Belisle, John T; Maslow, Joel N

    2004-01-01

    Background Mycobacterium avium are ubiquitous environmental organisms and a cause of disseminated infection in patients with end-stage AIDS. The glycopeptidolipids (GPL) of M. avium are proposed to participate in the pathogenesis of this organism, however, establishment of a clear role for GPL in disease production has been limited by the inability to genetically manipulate M. avium. Methods To be able to study the role of the GPL in M. avium pathogenesis, a ts-sacB selection system, not previously used in M. avium, was employed as a means to achieve homologous recombination for the rhamnosyltransferase (rtfA) gene of a pathogenic serovar 8 strain of M. avium to prevent addition of serovar-specific sugars to rhamnose of the fatty acyl-peptide backbone of GPL. The genotype of the resultant rtfA mutant was confirmed by polymerase chain reaction and southern hybridization. Disruption in the proximal sugar of the haptenic oligosaccharide resulted in the loss of serovar specific GPL with no change in the pattern of non-serovar specific GPL moieties as shown by thin layer chromatography and gas chromatography/mass spectrometry. Complementation of wild type (wt) rtfA in trans through an integrative plasmid restored serovar-8 specific GPL expression identical to wt serovar 8 parent strain. Results In this study, we affirm our results that rtfA encodes an enzyme responsible for the transfer of Rha to 6d-Tal and provide evidence of a second allelic exchange mutagenesis system suitable for M. avium. Conclusion We report the second allelic exchange system for M. avium utilizing ts-sacB as double-negative and xylE as positive counter-selection markers, respectively. This system of allelic exchange would be especially useful for M. avium strains that demonstrate significant isoniazid (INH) resistance despite transformation with katG. Through the construction of mutants in GPL or other mycobacterial components, their roles in M. avium pathogenesis, biosynthesis, or drug

  14. Utilization of a ts-sacB selection system for the generation of a Mycobacterium avium serovar-8 specific glycopeptidolipid allelic exchange mutant

    Directory of Open Access Journals (Sweden)

    Belisle John T

    2004-09-01

    Full Text Available Abstract Background Mycobacterium avium are ubiquitous environmental organisms and a cause of disseminated infection in patients with end-stage AIDS. The glycopeptidolipids (GPL of M. avium are proposed to participate in the pathogenesis of this organism, however, establishment of a clear role for GPL in disease production has been limited by the inability to genetically manipulate M. avium. Methods To be able to study the role of the GPL in M. avium pathogenesis, a ts-sacB selection system, not previously used in M. avium, was employed as a means to achieve homologous recombination for the rhamnosyltransferase (rtfA gene of a pathogenic serovar 8 strain of M. avium to prevent addition of serovar-specific sugars to rhamnose of the fatty acyl-peptide backbone of GPL. The genotype of the resultant rtfA mutant was confirmed by polymerase chain reaction and southern hybridization. Disruption in the proximal sugar of the haptenic oligosaccharide resulted in the loss of serovar specific GPL with no change in the pattern of non-serovar specific GPL moieties as shown by thin layer chromatography and gas chromatography/mass spectrometry. Complementation of wild type (wt rtfA in trans through an integrative plasmid restored serovar-8 specific GPL expression identical to wt serovar 8 parent strain. Results In this study, we affirm our results that rtfA encodes an enzyme responsible for the transfer of Rha to 6d-Tal and provide evidence of a second allelic exchange mutagenesis system suitable for M. avium. Conclusion We report the second allelic exchange system for M. avium utilizing ts-sacB as double-negative and xylE as positive counter-selection markers, respectively. This system of allelic exchange would be especially useful for M. avium strains that demonstrate significant isoniazid (INH resistance despite transformation with katG. Through the construction of mutants in GPL or other mycobacterial components, their roles in M. avium pathogenesis

  15. Réduire les coûts des opérations pétrolières Reducing Petroleum Operating Costs

    Directory of Open Access Journals (Sweden)

    Leprince P.

    2006-11-01

    Full Text Available L'analyse économique, dont les résultats sont rassemblés dans cet article, a porté sur la structure des coûts des grandes opérations pétrolières : exploration, développement et production des gisements et aussi transformation lorsque l'hydrocarbure découvert (pétrole lourd ou gaz naturel ne peut être acheminé par les voies classiques (pipe-line, tankers. Cette analyse a mis en évidence les postes sensibles sur lesquels il faut faire porter l'effort de recherche pour obtenir une réduction des coûts techniques globaux. En chiffrant les gains qu'il est possible d'obtenir, grâce à la mise en oeuvre des connaissances les plus avancées et des technologies les plus performantes, il a été possible de montrer que des gains substantiels peuvent être attendus, en particulier pour le pétrole difficile, dont le coût technique peut être ramené dans une zone acceptable dans les circonstances économiques qui prévaudront dans la prochaine décennie. This article gives the findings of an economic analysis of the structure of the major petroleum operating costs in the exploration, development and production of fields as well as processing when hydrocarbons which have been discovered (heavy oil or natural gas cannot be conveyed by conventional systems (pipeline, tankers. This analysis has revealed the sensitive items that require research efforts to reduce the overall technical costs. By giving figures for the improvements that can be made, as the result of the implementation of the most sophisticated know-how and the most efficient technologies, it is shown that substantial improvements can be expected, especially for difficultoil for which the technical cost can be brought down to an acceptable level in the economic circumstances that will prevail in the coming decade.

  16. Neurofibromatosis tipo 2: La historia de Lidia Neurofibromatosis type 2: Life story of Lidia

    Directory of Open Access Journals (Sweden)

    Ares Solanes

    2012-06-01

    Full Text Available La Neurofibromatosis tipo 2 (NF2 es una enfermedad minoritaria hereditaria caracterizada por la presentación progresiva de múltiples tumores, especialmente Schwanomas Vestibulares Bilaterales, a partir de la segunda década de vida. Su tratamiento con cirugía o radioterapia no evita la pérdida de audición. El pronóstico es complicado y los pacientes deben enfrentarse al progresivo deterioro de su calidad de vida. Un estudio cualitativo a través de la historia de vida de nuestra informante clave nos permite explorar y comprender su vivencia, afecta de Neurofibromatosis tipo II (NF2, así como conocer sus necesidades y aprender de sus recursos adaptativos.Neurofibromatosis type 2 (NF2 is a minority hereditary disease characterized by the development of multiple tumours, especially bilateral vestibular schwannomas, in young adults. Treatments with surgery or radiotherapy are performed to delay hearing loss. The prognosis is complicated and patients face the deterioration of their quality of life. A qualitative study through our key subject's life allows us to explore and understand her experience, as a NF2 sufferer, to identify her needs and to learn about her adaptive measures.

  17. Tipos de fraudes en carnes y productos cárnicos: una revisión

    Directory of Open Access Journals (Sweden)

    T. Espinoza

    2015-01-01

    Full Text Available En años recientes la importancia del control de alimentos, en cuanto a la identificación de sus componentes para evitar fraudes, ha crecido tanto en interés en las organizaciones estatales como en las empresas y en las industrias. La globalización, el aumento de las importaciones y exportaciones, y los tratados de libre comercio han propiciado un mayor intercambio y acceso de los alimentos a nivel mundial; junto con ello los problemas asociados a los fraudes tales como la adulteración, sustitución, la intencionalidad, y falsificación se han incrementado. Por ello, se han reportado varios trabajos asociados al fraude alimentario, donde en la mayoría de ellas se muestran aplicaciones de nuevas técnicas de identificación. Sin embargo, una discusión acerca de los tipos de fraude y su impacto sobre la sociedad, el bioterrorismo y la religión, ha sido poco abordada. Esta revisión se enfoca básicamente en describir los tipos de fraude en alimentos más comunes. Así como, se mencionan las recientes técnicas disponibles para detectar una adulteración en carnes.

  18. Tipos de tiempo para el turismo de sol y playa en el litoral alicantino

    Directory of Open Access Journals (Sweden)

    Martínez Ibarra, Emilio

    2008-06-01

    Full Text Available In this article the author proposes a series of weather types, with the purpose of evaluating the climatic-tourist potencial for the tourism of sun and beach in the coast of Alicante. The method, analysis of the frequency of the density of use of the practice the suntan and swin, the type of consulted source (webcam images, as well as the diversity of distinguished types, make of this work a novel contribution, in a branch of the knowledge relatively little cultivated although emergent: the Tourist Climatology.

    En el presente trabajo se proponen una serie de tipos de tiempo, con la finalidad de evaluar el potencial climático-turístico para el turismo de sol y playa en el litoral alicantino. El método, análisis de la frecuentación de la densidad de uso de la práctica del bronceado y baño, el medio a partir del cual se ha obtenido la información (imágenes webcam, así como la diversidad de tipos distinguidos, hacen de este trabajo una aportación novedosa, en una rama del conocimiento relativamente poco cultivada aunque emergente: la Climatología Turística.

  19. Opciones tipo barrera sobre la tasa de cambio Peso/Dólar

    Directory of Open Access Journals (Sweden)

    Ángela María Pérez Muñoz

    2007-12-01

    Full Text Available Este artículo es derivado de la investigación titulada Opciones tipo barrera sobretasa de cambio. Se realizó un examen de diversas metodologías existentes parala valoración y medición de los riesgos de las opciones tipo barrera europeas. Larevisión se centró, principalmente, en los métodos numéricos. Las SimulacionesMontecarlo constituyen una metodología para valorar y calcular las coberturas deopciones que dependen de la ruta seguida por los precios del activo subyacentedurante su vida útil. Los resultados generados corroboran que ellas convergensatisfactoriamente en la formulación analítica cuando ésta se ajusta a unaobservación discreta de los precios del activo subyacente. Tales resultados seajustan más cuando se aplica el Método de Control de Varianza de Variables Antitéticas a las Simulaciones Montecarlo. 

  20. Cuotas de género y tipo de lista en América Latina

    Directory of Open Access Journals (Sweden)

    Nélida Archenti

    2007-06-01

    Full Text Available Las reformas electorales llevadas a cabo en algunos países de América Latina, a partir de los '90, han producido resultados cuyo análisis es ineludible para la comprensión del acceso de las mujeres a los cargos electivos. En la actualidad, no existe un consenso respecto a cómo afectan los elementos del sistema electoral a la participación política femenina bajo las leyes de cuotas, en particular en lo referente al tipo de lista (bloqueada o desbloqueada y la magnitud de distrito. Este artículo intenta, a través del análisis de los resultados electorales de esas provincias, aportar nuevos elementos empíricos al debate sobre los efectos del tipo de lista en el acceso de las mujeres a los legislativos, en sistemas con cuotas de género.The electoral reforms implemented in some Latin American countries at the 90's have had a strong impact over the women access to elected positions, although there is not a consensus about the electoral systems ' components that affect the women participation in politics through especific electoral laws. This article analyses the effects of electoral mechanisms on women's participation in politics in some municiaplities in Argentina.

  1. ESTUDIO COMPARATIVO DE DUREZA EN DIENTES ARTIFICIALES FABRICADOS CON DIFERENTES TIPOS DE RESINAS ACRÍLICAS

    Directory of Open Access Journals (Sweden)

    Melissa Kurzer

    Full Text Available Existen en el mercado dientes artificiales a base de resina acrílica convencional, compuesta o IPN (interpenetrating polymer network. Cuando se comparan los dientes de resina acrílica con los dientes naturales, puede observarse que existe una diferencia significativa en algunas de sus propiedades. Una de estas es la dureza. En el presente proyecto, se comparó la dureza superficial Knoop de dientes acrílicos fabricados con diferentes tipos de resinas a base de PMMA (polimetilmetacrilato, con el fin de determinar si existen diferencias significativas entre ellos (ANOVA p < 0.05 y establecer si el tipo de resina acrílica empleada puede ser una alternativa para el mejoramiento de dicha propiedad en los dientes artificiales, de forma que sea más similar a la de los dientes naturales. Como resultado, se encontró que los dientes artificiales fabricados con resinas microrrellenas poseen mayor dureza que los de IPN o resina convencional. Sin embargo, aún distan de manera significativa de tener la misma dureza que el diente natural (esmalte 270-350 KHN y dentina 50-70 KHN.

  2. Los “Panzudos” Arcaicos Griegos: observaciones sobre un curioso tipo iconográfico

    Directory of Open Access Journals (Sweden)

    Arjona Pérez, Manuel

    2013-12-01

    Full Text Available In the 6th century BC, the vascular and cloroplastic workshops of Ancient reproduced, both on plastic vases and terracota figurines, an iconographic type depicting a peculiar nude and smiling fat-bellied male character. This paper deals with aspects related to the variants of this iconographic type, its distribution, the identification of the represented figure, its probable forerunners, as well as the context of the deposition or consecration of its representations.En el siglo VI a.C. los talleres vasculares y coroplásticos helenos reprodujeron, bien sobre vasos plásticos, bien sobre figuritas de terracota, un tipo iconográfico que representa a un curioso personaje masculino que, desnudo y sonriente, luce un vientre prominente. En este artículo tratamos algunas cuestiones relativas a las variaciones de este tipo iconográfico, la amplia difusión del mismo, la identificación del personaje retratado, sus posibles antecedentes y el contexto de la deposición o consagración de sus representaciones.

  3. Avaliação química de fertilizantes com micronutrientes tipo fritas

    Directory of Open Access Journals (Sweden)

    F. Vale

    2003-02-01

    Full Text Available O objetivo deste trabalho foi analisar fertilizantes tipo fritas comercializados no Brasil, utilizando o método prescrito para análise de fertilizantes minerais não-fritas, o que normalmente tem sido feito na rotina pelos laboratórios de análises de fertilizantes. Também foram analisados os teores de Cd, Ni e Pb nesses fertilizantes. Observou-se que o método utilizado foi adequado para a análise dos fertilizantes tipo fritas, o que indica que as fritas comercializadas no Brasil não são realmente fritas, isto é, silicatos fundidos com micronutrientes. A presença de micronutrientes metálicos nos produtos sem as respectivas garantias e a alta concentração de metais indesejáveis, principalmente Pb, são fortes indícios de utilização de resíduos industriais na fabricação desses fertilizantes. Sugere-se que sejam estudados e propostos extratores químicos para avaliar a eficiência agrícola desses produtos.

  4. MULHER, UMA CONSTRUÇÃO SOCIAL: REPRESENTAÇÕES, ESTEREÓTIPOS E IMAGENS

    Directory of Open Access Journals (Sweden)

    Rosana Rocha Siqueira

    2014-06-01

    Full Text Available O presente artigo tem como objetivo uma revisita a referenciais bibliográficos a partir dos quais foi possível refletir sobre a construção de estereótipos relacionados à imagem feminina no século XX partindo-se do conceito de representação proposto por Moscovici (2003. Pretende-se na convergência destas duas categorias (representação e imagem apresentar olhares sobre a construção de alguns estereótipos relacionados às mulheres, uma vez que diversas instituições inclusive o próprio movimento feminista em suas variadas vertentes também preocuparam-se em “criar” representações das mulheres. Algumas discussões presentes neste artigo fizeram parte do conteúdo da disciplina “Seminários avançados sobre produtos, processos e discursos midiáticos” ofertada pelo Núcleo de Pós-Graduação da Universidade Federal de Sergipe. Desta forma pode-se refletir sobre os variados recortes imagéticos dos quais as instituições e as próprias mulheres utilizaram-se para compor novas representações.

  5. Fenótipos clínicos de asma grave Clinical phenotypes of severe asthma

    Directory of Open Access Journals (Sweden)

    Roseliane de Souza Araújo Alves

    2008-09-01

    Full Text Available OBJETIVO: Estabelecer os fenótipos clínicos em portadores de asma grave. MÉTODOS: Foram estudados, retrospectivamente, 111 pacientes em um ambulatório especializado. Os pacientes foram avaliados e acompanhados de maneira sistemática, estabelecendo-se ao final do acompanhamento a adesão e o controle ou não da doença por dados clínicos e funcionais. A resistência ao tratamento foi definida como o não preenchimento, ao final do acompanhamento, por pelo menos seis meses, dos critérios de controle de asma, apesar do uso correto e adesão à medicação. Os fenótipos foram determinados por análise fatorial e comparados por testes diversos. RESULTADOS: Ao final, 88 pacientes foram considerados aderentes e 23 não aderentes. Por análise fatorial do grupo aderente, quatro fenótipos foram determinados: o fenótipo 1 (28 pacientes, formado pelos pacientes resistentes ao tratamento, com maior freqüência de sintomas noturnos, maior número de exacerbações e uso mais freqüente de broncodilatador de resgate; o fenótipo 2 (48 pacientes, formado pelos pacientes com obstrução persistente, com menores valores de relação volume expiratório forçado no primeiro segundo/capacidade vital forçada na avaliação inicial, idade mais avançada e maior tempo de doença; o fenótipo 3 (42 pacientes, representa os pacientes com rinossinusite alérgica, sendo constituído de não fumantes com obstrução predominantemente reversível; e o fenótipo 4 (15 pacientes, formado por casos com história de intolerância à aspirina associado à asma quase fatal. CONCLUSÕES: Um número significativo de portadores de ama grave não adere ao tratamento. Muitos pacientes com asma grave têm obstrução irreversível, mas o fenótipo clínico mais relevante é constituído pelos pacientes resistentes ao tratamento habitual.OBJECTIVE: To characterize clinical phenotypes of severe asthma. METHODS: A total of 111 patients were retrospectively evaluated at a

  6. Tipos polínicos coletados por Nannotrigona testaceicornis e Tetragonisca angustula (Hymenoptera, Apidae, Meliponinae

    Directory of Open Access Journals (Sweden)

    Carvalho Carlos Alfredo Lopes de

    1999-01-01

    Full Text Available Os tipos polínicos coletados no mesmo pasto apícola por Nannotrigona testaceicornis e Tetragonisca angustula (Hymenoptera, Apidae, Meliponinae foram estudados e comparados durante dois meses em Piracicaba-SP, (22o43'S; 47o25'W; altitude: 580m. As massas de pólen foram obtidas através da captura de operárias que retornavam à colônia das 5:00 às 19:00 horas nos meses de outubro e novembro de 1996. Trinta e um tipos polínicos pertencentes a 22 famílias foram identificados, dos quais 22,58% foram coletados exclusivamente por N. testaceicornis, 35,48% por T. angustula e 41,94%, por ambas as espécies. As famílias Fabaceae, Liliaceae, Mimosaceae e Myrtaceae e as espécies Bulbine frutescens, Eucalyptus spp., Leucaena leucocephala e Tipuana tipu foram as mais freqüentes e constantes durante os trabalhos. O índice de similaridade entre as fontes de pólen explorada pelas abelhas foi igual a 0,78.

  7. Neurofibromatosis tipo I con pubertad precoz: Presentación de un caso

    Directory of Open Access Journals (Sweden)

    Bárbara M. Esquejarosa Roque

    1998-06-01

    Full Text Available La neurofibromatosis tipo I o neurofibromatosis de Von Reckinghausen es el trastorno neurocutáneo más frecuente. Se presenta en 1 de cada 3 000 personas y se hereda por vía autosómica dominante. Los criterios para su diagnóstico clínico fueron establecidos en 1988. Su asociación con la pubertad precoz, aunque se ha descrito, se considera poco frecuente. En nuestro trabajo se presenta un niño de 3 años con neurofibromatosis tipo I y pubertad precoz. Se destacan las manifestaciones clínicas y la importancia de los estudios imagenológicos para completar el diagnóstico.Neurofibromatosis type I ort Von Reckinghausen´s disease is the most common neurocutaneous disorder. It appears in one of every 3 000 persons and it is inherited by dominant autosomal route. The criteria for its diagnosis were established in 1988. Its association with preccocius puberty, although it has been described, is considered as rare. A 3-year-old child with neurofibromatosis type I and precocious puberty is presented in this paper. Emphasis is made on the clinical manifestation and on the importance of the image studies to complete the diagnosis.

  8. Fundamentos del tipo de cambio real en Costa Rica (2001-2014

    Directory of Open Access Journals (Sweden)

    Raúl Fonseca Hernández

    2017-05-01

    Full Text Available El documento está orientado a profesionales de ciencias sociales con el objetivo de orientarles en la comprensión del comportamiento del Índice de Tipo de Cambio Real de Costa Rica (ITCER en relación con sus fundamentos. Se utiliza el modelo teórico behavioral equilibrium exchange rate (BEER para identificar y analizar los efectos en estas variables sobre el ITCER. Los seis indicadores analizados fueron: términos de intercambio, absorción fiscal, IED, tasa de interés real doméstica y productividad relativa de la economía. Estos explican adecuadamente el comportamiento del tipo de cambio real, pese a presentar una gran variabilidad. Se identifican claramente dos periodos en el comportamiento del ITCER: el primero (2001 y 2005, se presenta un periodo de depreciación, observándose posteriormente (2006 y 2014 un marcado proceso de apreciación en términos reales del colón costarricense.

  9. El polimorfismo (CAGn del gen ATXN2, nuevo marcador de susceptibilidad para diabetes mellitus tipo 2

    Directory of Open Access Journals (Sweden)

    Luis J. Flores-Alvarado

    Full Text Available RESUMEN Objetivo Estimar si hay asociación del repetido (CAGn del gen ATXN2 en población mexicana con diabetes mellitus (DM tipo 2. Métodos Estudio epidemiológico de casos y controles. Se incluyeron personas sanas y personas diabéticas. La detección de la expansión (CAGn se realizó por reacción en cadena de la polimerasa (PCR-punto final. Los productos de PCR se analizaron mediante electroforesis (PAGE al 8% y tinción con nitrato de plata. Resultados La distribución de alelos del trinucleótido (CAGn en la población analizada resultó similar a la reportada en el centro del país. El alelo más frecuente es el de 22 repetidos; sin embargo, hay asociación con los portadores de los repetidos largos dentro del rango normal con diabetes. Conclusiones Los resultados sugieren que el repetido (CAGn del gen de ATXN2 podría ser un factor causal de DM tipo 2.

  10. Diabetes tipo 2 en niños: Reporte de caso

    Directory of Open Access Journals (Sweden)

    Miguel Pinto

    2010-04-01

    Full Text Available Se reporta el caso de una niña de 14 años con antecedentes de obesidad, dislipidemia y diabetes que es referida a nuestro servicio por polidipsia, poliuria y sobrepeso. La paciente tenía el antecedente familiar de ambos padres con diagnóstico de diabetes tipo 2. El examen físico mostró obesidad central y acantosis nigricans severa en los pliegues cutáneos. Los análisis de laboratorio mostraron hiperglicemia, hiperinsulinemia y péptido C normal. Los autoanticuerpos anti-GAD y anti-ICA fueron negativos. El tratamiento con metformina fue continuado; y la dieta y actividad física fueron reforzadas. Actualmente, los niveles de hemoglobina glicosilada y glicemia en ayunas han mejorado. El incremento en la obesidad infantil ha resultado en un marcado aumento en la incidencia de síndrome metabólico y diabetes tipo 2 en la población infantil.(Rev Med Hered 2010;21:103-106.

  11. An improved FEM model for computing transport AC loss in coils made of RABiTS YBCO coated conductors for electric machines

    Energy Technology Data Exchange (ETDEWEB)

    Ainslie, Mark D; Yuan Weijia; Flack, Timothy J; Coombs, Timothy A [Department of Engineering, University of Cambridge, 9 J J Thomson Avenue, Cambridge CB3 0FA (United Kingdom); Rodriguez-Zermeno, Victor M [Department of Mathematics, Technical University of Denmark, Kongens Lyngby 2800 (Denmark); Hong Zhiyong, E-mail: mda36@cam.ac.uk [School of Electronic, Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai (China)

    2011-04-15

    AC loss can be a significant problem for any applications that utilize or produce an AC current or magnetic field, such as an electric machine. The authors investigate the electromagnetic properties of high temperature superconductors with a particular focus on the AC loss in superconducting coils made from YBCO coated conductors for use in an all-superconducting electric machine. This paper presents an improved 2D finite element model for the cross-section of such coils, based on the H formulation. The model is used to calculate the transport AC loss of a racetrack-shaped coil using constant and magnetic field-dependent critical current densities, and the inclusion and exclusion of a magnetic substrate, as found in RABiTS (rolling-assisted biaxially textured substrate) YBCO coated conductors. The coil model is based on the superconducting stator coils used in the University of Cambridge EPEC Superconductivity Group's all-superconducting permanent magnet synchronous motor design. To validate the modeling results, the transport AC loss of a stator coil is measured using an electrical method based on inductive compensation by means of a variable mutual inductance. Finally, the implications of the findings on the performance of the motor are discussed.

  12. Robust Fault Estimation for a Class of T-S Fuzzy Singular Systems with Time-Varying Delay via Improved Delay Partitioning Approach

    Directory of Open Access Journals (Sweden)

    Chao Sun

    2016-01-01

    Full Text Available The problem of delay-dependent robust fault estimation for a class of Takagi-Sugeno (T-S fuzzy singular systems is investigated. By decomposing the delay interval into two unequal subintervals and with a new and tighter integral inequality transformation, an improved delay-dependent stability criterion is given in terms of linear matrix inequalities (LMIs to guarantee that the fuzzy singular system with time-varying delay is regular, impulse-free, and stable firstly. Then, based on this criterion, by considering the system fault as an auxiliary disturbance vector and constructing an appropriate fuzzy augmented system, a fault estimation observer is designed to ensure that the error dynamic system is regular, impulse-free, and robustly stable with a prescribed H∞ performance satisfied for all actuator and sensor faults simultaneously, and the obtained fault estimates can practically better depict the size and shape of the faults. Finally, numerical examples are given to show the effectiveness of the proposed approach.

  13. Chemical surface treatment with toluene to enhance sensitivity of NO2 gas sensors based on CuPcTs/Alq3 thin films

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    Mahdi H. Suhail

    2017-09-01

    Full Text Available A nitrogen dioxide (NO2 gas sensor based on the blend of copper phthalocyanine-tetrasulfonic acid tetrasodium/tris-(8-hydroxyquinolinealuminum (CuPcTs/Alq3 thin films was fabricated. The effect of chemical surface treatment with toluene on the structural, surface morphology and device sensitivity has been examined. The X-ray diffraction (XRD patterns of as-deposited and toluene-treated films exhibit a broad hump peak at 2θ = 24°. The atomic force microscopy (AFM measurements show that the average particle diameter decreases with immersing time. The needle like shapes can be seen from scanning electron microscopy (SEM images for films treated with toluene for an immersing time of 60 min. Gas sensor characterizations demonstrate that all samples have superior NO2 gas sensitivity at a operating temperature of 373 K. The increase of the sensor sensitivity with increasing chemical treatment time up to 60 min was observed. All films show the stable and repeatable response patterns.

  14. Influence of ecological factors on the production of active substances in the anti-cancer plant Sinopodophyllum hexandrum (Royle) T.S. Ying.

    Science.gov (United States)

    Liu, Wei; Liu, Jianjun; Yin, Dongxue; Zhao, Xiaowen

    2015-01-01

    The quality of traditional Chinese herbal medicine, which plays a very important role in the health system of China, is determined by the active substances produced by the plants. The type, content, and proportion of these substances may vary depending on ecological factors in areas where the plants are grown. Sinopodophyllum hexandrum (Royle) T.S. Ying, an endangered plant species with great medical value, was investigated in eight production locations representative of its natural geographical distribution range in China. The correlation between the contents of the active ingredients extracted from the roots and rhizomes of S. hexandrum and the ecological factors were evaluated step-by-step using a series of computational biology methodologies. The results showed that ecological factors had significant effects on the contents but not on the types of the active ingredients in eight production locations. The primary ecological factors influencing the active substances included the annual average precipitation, July mean temperature, frost-free period, sunshine duration, soil pH, soil organic matter, and rapidly available potassium in the soil. The annual average precipitation was the most important determinant factor and was significantly and negatively correlated with the active ingredient contents (P Shangri-La, Yunnan Province, and Nyingchi, Tibet, conditions were favorable to the production of quercetin and kaempferol.

  15. Influência da temperatura sobre os tipos celulares presentes na hemolinfa de larvas e ninfas de Rhipicephalus sanguineus

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    Carneiro M.E.

    2003-01-01

    Full Text Available Este trabalho foi realizado com o intuito de se verificar a influência de três temperaturas (18, 27 e 32°C sobre os tipos celulares presentes na hemolinfa de larvas e ninfas de Rhipicephalus sanguineus (Latreille, 1806. Seis tipos celulares básicos foram encontrados na hemolinfa: prohemócitos (PR, plasmatócitos (PL, granulócitos (GR, esferulócitos (ES, adipohemócitos (AD e oenocitóides (OE. Os ES foram divididos em dois subtipos (ES I e ES II, devido às variações morfológicas encontradas. O efeito da temperatura foi mais acentuado sobre o estádio de larva. Ocorreu queda acentuada de GR e aumento de ES II na temperatura de 18°C, enquanto que à 27 e 32°C, os valores foram semelhantes. GR foi o tipo celular mais abundante, indicando o seu envolvimento no metabolismo. Para ninfas este também foi o tipo celular mais abundante, porém não ocorreram variações acentuadas segundo a temperatura, indicando que cada estádio de desenvolvimento apresenta determinada necessidade metabólica que se expressa nos tipos celulares presentes na hemolinfa.

  16. Tipo de ecolalia em crianças com Transtorno do Espectro Autista

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    Marina Mergl

    2015-12-01

    Full Text Available RESUMO: O Transtorno do Espectro Autista (TEA é uma síndrome caracterizada por prejuízos persistentes na comunicação social recíproca, com interação social restrita e padrões repetitivos de comportamentos, interesses e atividades. Os comportamentos repetitivos na linguagem podem manifestar-se pelo aparecimento da ecolalia, fenômeno persistente caracterizado como um distúrbio de linguagem, com repetição da fala do outro, dividida em imediata ou tardia. Teve como objetivo a verificação do tipo de ecolalia e das habilidades comunicativas em sete meninos com TEA, com idades entre quatro e sete anos, que fazem uso da comunicação oral. Foram realizadas duas atividades distintas: avaliação das crianças em uma sessão de atendimento fonoaudiológico em situação lúdica, analisada pelo Protocolo de Observação Comportamental e aplicação de um questionário com os pais e profissionais para verificar suas opiniões quanto ao uso, tipo e frequência de ecolalia. Das sete crianças do estudo, seis apresentaram ecolalia imediata e uma tardia; a criança que utilizou ecolalia tardia apresentou menor pontuação no protocolo de observação comportamental, porém para os demais sujeitos não houve relação direta entre o tipo e número de ecolalia com a pontuação. O questionário aplicado com pais e profissionais mostrou concordância quanto à presença da ecolalia. As crianças com TEA deste estudo apresentaram habilidades comunicativas e aspectos do desenvolvimento cognitivo comprometidos e maior número de ecolalias imediatas. Estudos com o tema ecolalia ainda são escassos na literatura nacional. Este relato de casos clínicos pode contribuir para futuras pesquisas sobre a caracterização da linguagem em crianças com TEA e conduta terapêutica dos fonoaudiólogos.

  17. El virus de la inmunodeficiencia humana tipo 1 y el sistema nervioso central en desarrollo.

    Directory of Open Access Journals (Sweden)

    Jorge Alejandro Henao

    2005-03-01

    Full Text Available Actualmente, hay más de 42 millones de infectados con el virus de la inmunodeficiencia humana tipo 1 (VIH-1, de los cuales, 3,2 millones son niños y, de éstos, el 90% con transmisión vertical de la infección. Se considera que en Colombia más de 200.000 personas se han infectado desde el inicio de la pandemia y los estudios muestran una tendencia constante al aumento en las cifras de seroprevalencia en mujeres embarazadas y, por ende, en el número de recién nacidos infectados. El VIH-1 es primordialmente linfotrópico, pero su tropismo por el sistema nervioso central (SNC es bien conocido, lo que genera múltiples alteraciones neurológicas, particularmente prominentes en niños, de las cuales la más prevalerte es la encefalopatía. Clásicamente, se reconocen dos tipos de encefalopatía en esta población: encefalopatía temprana y tardía, ambas con diferentes características clínicas e inmunológicas. La infección por el VIH-1 en el SNC está limitada a los macrófagos, la microglía y los astrocitos en menor escala. Las neuronas, células principalmente afectadas en los pacientes con sida, raras veces son infectadas, por lo que se postula que factores solubles, provenientes tanto del huésped como del virus, son los principales causantes del daño neuronal. Los hallazgos presentados en esta revisión sugieren la posibilidad de que el SNC, en etapas tempranas del desarrollo, sea especialmente susceptible a la infección por el VIH-1. Las cifras epidemiológicas sugieren que este tipo de alteraciones clínicas serán cada vez más frecuentes; de ahí, la importancia de conocer la neuropatogénesis de la infección por el VIH-1.

  18. Relaciones entre estilos de personalidad y tipos de consumo de alcohol

    Directory of Open Access Journals (Sweden)

    Jairo Andrés Castañeda Arcila

    2013-01-01

    Full Text Available Objetivo. Esta investigación buscó identificar, en la población adulta del municipio de El Retiro (Antioquia, los tipos de consumo de alcohol, así como su relación con estilos de personalidad. Método. Se realizó un estudio transversal, descriptivo y correlacional. Se aplicaron dos instrumentos, Millon Inventory of Personality (MIPS y Alcohol Use Disorder Identification Test (Audit en una muestra de 61 participantes, de los cuales 33 fueron hombres y 28 mujeres. Resultados. El tipo de consumo de bebidas alcohólicas más frecuente en el municipio de El Retiro fue el consumo sin riesgo (68.9%. Además, se presentaron diferencias estadísticamente significativas en el tipo de consumo de alcohol según el género. Particularmente, los hombres registraron dependencia al alcohol. Asimismo, se halló que en los hombres el consumo de alcohol se encuentra relacionado con los estilos de personalidad como la innovación (r = 0.35, la discrepancia (r = 0.40 y el dominio (r = 0.46; mientras que en las mujeres se relacionan con la discrepancia (r = 0.38, la expansión (r = 0.39, la modificación (r = 0.40 y la adecuación (r = 0.42. Para ambos géneros, el consumo de riesgo se correlaciona con el estilo de sistematización (r = 0.67, el consumo perjudicial con la protección (r = 0.89 y la dependencia al alcohol con la indecisión (r = 0.99. Conclusión. Las tres categorías en las que se agrupan los estilos de personalidad (metas motivacionales, modos cognitivos y comportamientos interpersonales, se asociaron diferencialmente con el consumo sin riesgo, con riesgo, perjudicial y dependencia, encontrando que estas relaciones entre estilo de personalidad y consumo también muestran diferencia por género.

  19. Os tipos psicológicos e as competências nos novos modelos de gestão

    OpenAIRE

    Mello, Carla Virmond

    2003-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção. Analisa os aspectos de relação das características de personalidade, através do estudo dos Tipos Psicológicos de Jung, com as novas demandas de gestão por parte das organizações. Estuda a relação dos tipos psicológicos com as competências exigidas dos gerentes para enfrentar uma gestão contemporânea e como a distribuição dos tipos acontece nas organiza...

  20. FACES DO FEMININO SAGRADO: O ARQUÉTIPO DA MULHER SELVAGEM

    OpenAIRE

    Martins, Camila Alves

    2006-01-01

    As imagens do feminino sagrado encontram-se apagadas diante da formação do poderio masculino, por isso, a busca de um espaço de integração entre o princípio feminino e o masculino se faz necessária. O trabalho é uma pesquisa teórica e qualitativa dividida em três capítulos que retrata uma analogia entre o arquétipo da Mulher Selvagem , a figura mítica de Lilith, e a personagem bíblica de Maria Madalena. Na historicidade dos relatos míticos percebemos uma imagem demonizada das ...

  1. Comportamento experimental de diferentes tipos de conectores metálicos

    OpenAIRE

    Valente, Isabel B.

    2016-01-01

    A realização de estruturas mistas de aço e betão requer o funcionamento conjunto destes dois materiais. A ligação entre eles é conseguida com a utilização de conectores metálicos. Neste âmbito, tem sido realizada uma considerável quantidade de estudos que abordam o comportamento de diversos tipos de conectores metálicos. O desejo de obter um comportamento óptimo com custos mínimos motivou o desenvolvimento de várias soluções. Neste artigo, procura-se descrever o comportamento de diferente...

  2. Repercussões psicossomáticas da hipnose em pessoas com diabetes Mellitus tipo 2

    OpenAIRE

    Mateus, Rodrigo Cazarotto

    2008-01-01

    Esta pesquisa é o resultado da dissertação de mestrado em Psicologia Clínica do Núcleo de Psicossomática e Psicologia Hospitalar da PUC-SP. A pesquisa teve como objetivo verificar se existe alteração no nível de glicemia e na sensação de bem estar em pessoas com Diabetes Mellitus tipo II após vivenciarem situações agradáveis através da hipnose Ericksoniana, bem como analisar os resultados encontrados nessa investigação. Dez sujeitos compuseram o grupo intervenção e oito sujeitos compuseram o ...

  3. Adolescentes com Diabetes Mellitus Tipo 1: Estresse, enfrentamento e adesão ao tratamento

    OpenAIRE

    Victório, Vanessa Marques Gibran

    2016-01-01

    O Diabetes Mellitus Tipo 1 (DM1) é uma condição crônica de saúde caracterizada pelo excesso de glicose no sangue e produção deficiente de insulina pelo pâncreas, exigindo a ingestão diária de insulina para o controle metabólico. Este é afetado por variáveis psicossociais, especialmente durante a adolescência, que é uma fase de risco para reações de estresse. A forma como o adolescente lida com o estresse depende, em parte, de seu repertório de enfrentamento. As estratégias de enfrentamento [E...

  4. Incidencia en los tipos de acoso sexual en el trabajo en España

    Directory of Open Access Journals (Sweden)

    Cristina Cuenca-Piqueras

    2014-01-01

    Full Text Available El acoso sexual en el trabajo ha sido clasificado de muy diversas formas debido a los diferentes comportamientos que se incluyen bajo este concepto. En el presente trabajo se analizan las múltiples tipologías de acoso sexual, realizando una propuesta propia. Además, se pretende comprobar que esta clasificación tiene sentido práctico utilizando la Técnica del Escalamiento Multidimensional ( alscal , y al mismo tiempo, comprobar la fuerza explicativa de la Teoría multidimensional del acoso en España. Los resultados muestran diferencias respecto al conjunto de nacionales y extranjeras, pues las mujeres migrantes sufren los tipos más graves de acoso sexual en mayor proporción que las autóctonas.

  5. Psicologia Ambiental e estudos pessoas-ambiente: que tipo de colaboração multidisciplinar?

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    Gabriel Moser

    2005-01-01

    Full Text Available Este artigo procura definir quais as colaborações existentes entre a Psicologia Ambiental e os diversos estudos pessoas-ambiente a partir dos trabalhos inscritos no Congresso IAPS-16 (Paris, 2000. Na relação entre transdiciplinaridade, pluridisciplinaridade e interdisciplinaridade, entende que o funcionamento científico é necessariamente mono-disciplinar, enquanto a intervenção nas relações pessoas-ambiente envolve uma dinâmica complexa. Quanto à intervenção (manejo sócio-ambiental, distingue dois tipos de funcionamento: interdisciplinar e transdisciplinar. Conclui por um conhecimento que integre as diversas abordagens disciplinares em abordagens transdiciplinares.

  6. SELEÇÃO DE TIPOS DE FONTES DE INFORMAÇÃO

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    Claudia Carmem Baggio

    2016-12-01

    Full Text Available Fontes de informação são parte integral dos serviços de informação prestados aos usuários. Identificá-las é o primeiro passo para buscar e recuperar informação pontual. Este artigo apresenta o conceito de fontes de informação e sua classificação, bem como os possíveis instrumentos para localização de fontes de informações, apresentando os conceitos, os tipos e os exemplos de repositórios, catálogos, bibliografias, portais, diretórios e bases de dados.

  7. Causas y consecuencias del hipogonadismo en varones con diabetes mellitus tipo 2

    OpenAIRE

    Herrero Ruiz, Ana

    2016-01-01

    [ES]Existe una elevada prevalencia de déficit androgénico en los varones con DM tipo 2 (DM2) pero no está claro el mecanismo por el que están relacionados. Por ello, sería interesante conocer los factores clínicos, antropométricos, analíticos o terapéuticos que suponen un riesgo para el déficit de testosterona en el diabético. Aunque se han efectuado varios estudios sobre las relaciones del nivel endógeno de testosterona con la diabetes en varones, muy pocos trabajos han evaluado estos objeti...

  8. Esporotricosis cutánea diseminada con compromiso articular en una mujer con diabetes tipo 2

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    Sendy Solorzano

    Full Text Available La esporotricosis diseminada es una presentación infrecuente de esta micosis. Aunque ha sido descrita en sujetos inmunocompetentes, con frecuencia existe compromiso de la inmunidad mediada por células T. Reportamos el caso de una mujer con diabetes tipo 2 no controlada que desarrolló esporotricosis cutánea diseminada. El curso de la enfermedad presentó varias complicaciones que incluyeron hepatitis secundaria a itraconazol y artritis de la rodilla con cultivo positivo para Sporothrix schenckii durante el tratamiento con solución saturada de ioduro de potasio. La discusión del caso incluye aspectos de la patogénesis de la esporotricosis diseminada y el manejo de la infección y sus complicaciones.

  9. Depresion, el cortisol urinario y perfil sociodemografico em portadores de diabetes mellitus tipo 2

    OpenAIRE

    Nascimento, Alexandra Bulgarelli do; Chaves, Eliane Corrêa; Grossi, Sonia Aurora Alves

    2009-01-01

    O objetivo deste estudo foi investigar a relação entre indicadores de depressão e perfil sócio-demográfico de portadores de Diabetes Mellitus tipo 2 (DM2).A avaliação sócio-demográfica foi conduzida em amostra composta por 40 pacientes na Liga de Diabetes (HC-FMUSP).Os indicadores de depressão foram investigados a partir do Inventário de Depressão de Beck (IBD) em associação com cortisol urinário (CORT).Os resultados mostraram que indivíduos portadores de DM2 com alta escolaridade, baixo pode...

  10. Ciclo vigília/sono em portadores de diabetes mellitus tipo 1.

    OpenAIRE

    Mark Thomaz Ugliara Barone

    2011-01-01

    O objetivo do presente estudo foi avaliar possíveis relações entre o diabetes mellitus tipo 1 (DM1) e controle glicêmico, e o ciclo vigília/sono. Participaram 18 voluntários com DM1 (idade: 26,3±5,1), sem complicações, não obesos, sem alterações no sono; e 9 no grupo controle (idade: 28,8±5,3). Os dados foram coletados através de: diário de sono e de glicemia, actímetria (Tempatilumi), polissonografia, 6-sulfatoximelatonina, questionário de Epworth, e sensor de glicose durante a polissonograf...

  11. Un nuevo tipo de horno para cocción rápida

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    Editorial, Equipo

    1959-12-01

    Full Text Available Not availableLa firma alemana Emil Bott, de Rauenberg, que desde hace ochenta años produce tejas, ha montado una moderna instalación automática para el moldeo, secado y cocción de tejas de gran formato. Tales innovaciones represen tan un experimento atrevido, puesto que toda la instalación se ha concebido con el fin de producir un solo tipo y un solo modelo de teja. Estas piezas cubren a razón de 10 por metro cuadrado, pudiendo colocarse con inclinaciones de hasta un 12 o 15°. Nos encontramos, pues, ante un caso de extrema especialización.

  12. Beneficios del ejercicio físico en la Diabetes Méllitus tipo 2

    OpenAIRE

    Bustamante Montalbillo, Irati

    2015-01-01

    Introducción: La DM se está convirtiendo en una gran epidemia afectando a millones de personas en todo el mundo. El ejercicio físico acompañado de unos hábitos de vida saludables, producen grandes beneficios sobre los pacientes diabéticos tipo 2, tanto en su prevención como en sus complicaciones. Objetivo: Valorar la eficacia del ejercicio físico acompañado de hábitos de vida saludables en la mejora del control metabólico. Metodología: A través de diferentes bases de datos y con las pal...

  13. HEURÍSTICA PARA EL EQUILIBRADO DE LÍNEAS DE ENSAMBLES DEL TIPO TSS

    OpenAIRE

    Palominos Belmar,Pedro; Godoy Villalobos,Verónica

    2010-01-01

    El propósito de este trabajo es presentar una heurística para el problema de equilibrado de líneas para células conformadas en "U". Particularmente para el sistema de fabricación denominado Toyota Sewing System (TSS), que representa un nuevo concepto de organización en una línea de producción. Si bien este tipo de sistema ha sido abordado en la literatura bajo el título de sistemas de producción autoequilibrado, en donde el equilibrio se logra mediante la utilización de dos reglas básicas, cr...

  14. Papel de la insulina en el tratamiento de la diabetes mellitus tipo II

    OpenAIRE

    Alberto Quirantes Hernández; Leonel López Granja; Alipio Gil Sosa

    1997-01-01

    Se hace una revisión de las características clínicas, epidemiológicas y sociales de la diabetes mellitus tipo II (DMTII). Se analiza la fisiopatología de esta entidad y su manejo terapéutico, y se exponen los mecanismos de acción de las sulfonilureas y la conducta que clásicamente se ha seguido ante el fallo secundario a la acción de este medicamento y que ha consistido en sustituirlo, con la administración insulina lenta en su lugar. En etapas más recientes se plantea que en estos casos se m...

  15. Genótipos de sorgo para produção de barra de cereais

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    Valéria Aparecida Vieira Queiroz

    2012-02-01

    Full Text Available O objetivo deste trabalho foi desenvolver uma barra de cereais com pipoca de sorgo e avaliá-la quanto à aceitação do produto por consumidores, assim como identificar genótipos de sorgo e distintos modos de processamento para a produção de pipoca visando maior rendimento. Foram avaliados os processamentos sem (STH e com tratamento hidrotérmico (CTH dos grãos antes do pipoqueamento. O tratamento CTH reduziu o percentual de piruás em cerca de 36% e aumentou o rendimento da produção de pipoca em cerca de 80%. No STH, os genótipos BRS 310, BR 501, BR 506 e CMSXS 283 produziram menor percentual de piruás e maior capacidade de expansão. No CTH, 'BRS 310' e 'CMSXS 283' apresentaram melhor desempenho. Uma pesquisa sobre a aceitação e a intenção de compra das barras de cereais foi realizada em Londrina, PR e no Rio de Janeiro, RJ. Verificou-se que o produto foi aceito por 98, 4 e 76, 5% dos consumidores, e a média de aceitação, em uma escala de 1 a 9, foi de 7, 7 em Londrina e de 7, 1 no Rio de Janeiro. Quanto à intenção de compra, verificou-se que 88, 8% dos londrinenses e 80, 6% dos cariocas atribuíram notas acima de 4 ("talvez não comprasse, talvez comprasse" na escala de 7 pontos utilizada.

  16. Estabilidade de produtos de pequi (Caryocar coriaceum Wittm sob congelamento em diferentes tipos de embalagens

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    Joaci Pereira de Souza

    2013-12-01

    Full Text Available Avaliaram-se as características de qualidade de pequi (C. coriaceum congelado e acondicionado em diferentes embalagens, armazenados a -18º C, durante 300 dias. Os frutos, coletados na safra de 2009/2010, foram descascados, obtendo-se assim os caroços, que, após sanificados, foram submetidos a 3 tipos de embalagens: 1 - Cortados em lâminas de aproximadamente 2 mm de espessura de polpa e seladas a vácuo em polietileno de alta densidade (PEAD; 2 - Caroços embalados e selados a vácuo em sacos de PEAD; 3 - Caroços dispostos em bandejas de poliestireno expandido e envoltos por filme plástico. As amostras foram avaliadas aos 0; 60; 120; 180; 240 e 300 dias de armazenamento. Utilizou-se um delineamento inteiramente casualizado, em esquema fatorial, e os resultados foram submetidos a análises de variância e regressão. O congelamento do pequi submetido aos três tipos de acondicionamento foi eficiente na preservação das características de qualidade como: pH, acidez titulável e açúcares totais durante 300 dias de armazenamento. Os teores de carotenoides e polifenóis extraíveis totais mostraram redução acentuada no acondicionamento da polpa a vácuo. A forma mais indicada de congelamento do pequi para a manutenção da cromaticidade é o acondicionamento do caroço a vácuo ou em bandeja com filme de PVC.

  17. PROPUESTA DE REFORZAMIENTO PARA EDIFICACIÓN EDUCATIVA TIPO ANTIGUOII-MOP VENEZUELA

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    J. Yépez

    2016-12-01

    Full Text Available Se presenta en este artículo el estudio de reforzamiento estructural para una edificación de uso educativo, conocida como “Tipo Antiguo II”. La escuela fue construida antes de la creación de la Norma Venezolana Sismorresistente Covenin 1756. Los resultados del análisis estructural demostraron insuficiente capacidad de respuesta ante las solicitaciones de servicio, alta vulnerabilidad ante la acción sísmica y deficiencias en la cantidad y distribución del acero de refuerzo. Por tal motivo se planteó el reforzamiento de la superestructura mediante la construcción de muros tipo panel, verificando su acción sobre el sistema de pilotaje existente. Para el modelaje se emplearon los valores de resistencia del concreto obtenidos en los ensayos destructivos realizados por el laboratorio de materiales del Decanato de Ingeniería Civil de la Universidad Centroccidental Lisandro Alvarado, y los parámetros del suelo provenientes del estudio geotécnico. This article presents the study of structural reinforcement for a building of educational use, known as "Old Type II". The school was built before the creation of the Venezuelan Seismoresistant Covenin 1756. The results of the structural analysis showed insufficient responsiveness to service requests, high vulnerability to seismic action and deficiencies in the quantity and distribution of reinforcing steel. For this reason, the reinforcement of the superstructure was proposed by the construction of panel walls, verifying their action on the existing piloting system. For the modeling, the values of resistance of the concrete obtained in the destructive tests made by the materials laboratory of the School of Civil Engineering of the Universidad Centroccidental Lisandro Alvarado and the soil parameters from the geotechnical study were used.

  18. Tipo de Cambio Real entre Córdoba y Buenos Aires

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    Federico Fawaz

    2017-09-01

    Full Text Available El objetivo de este trabajo es estudiar las diferencias en la estructura de precios entre Córdoba y Buenos Aires. En términos generales, el costo de vida más alto en Buenos Aires que en el interior del país. Debido a la alta integración de los mercados regionales nacionales, los bienes transables no presentan grandes discrepancias de precios, las cuales sí se observan en los bienes no transables. Los términos de intercambio y las diferencias de productividad entre regiones, a través de su impacto en los salarios relativos, se destacan como el principal determinante del Tipo de Cambio Real. Aunque en menor medida, las asimetrías en las políticas públicas y las diferencias en las densidades de población, también tienen un impacto sobre la estructura regional de precios.Clasificación JEL: R10.Palabras clave: Tipo de Cambio Real, Mercados Regionales, Córdoba, Buenos Aires. Real Exchange Rate between Cordoba and Buenos Aires AbstractThe objective of this work is to study the differences in the price structure between Córdoba and Buenos Aires. In general terms, the higher cost of living in Buenos Aires than in the interior of the country. Due to the high integration of national regional markets, tradable goods do not present major price discrepancies, which are observed in nontradables. The terms of trade and productivity differences between regions, through their impact on relative wages, stand out as the main determinant of the Real Exchange Rate. To a lesser extent, asymmetries in public policies and differences in population densities also have an impact on the regional price structure.JEL Classification: R10Keywords: Real Exchange Rate, Regional Markets, Cordoba, Buenos Aires.

  19. Vehículos tipo para el transporte urbano de pasajeros en Colombia

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    Jorge Sánchez Gómez

    1988-01-01

    Full Text Available Con el copatrocinio del Instituto Nacional del Transporte - INTRA Y en el marco del Proyecto de Consumo, Conservación y Sustitución de Energía en el sector transporte, realizado conjuntamente por el Ministerio de Obras Públicas y Transporte, el Ministerio de Minas y Energía, el Departamento Nacional de Planeación y la Organización de Estados Americanos - OEA, la Universidad Nacional de Colombia a través del Instituto de Ensayos e Investigación de la Facultad de Ingeniería desarrolló el estudio "Diseño Optimizado de un Vehículo Diesel de Pasajeros para Operación Urbana en Colombia", comúnmente conocido como "Bus Tipo". En una primera parte se analiza cuales son las características predominantes en el transporte colectivo de pasajeros en las trece (13 principales ciudades colombianas teniendo en cuenta los aspectos del equipo, de la infraestructura y de la estructura o sistema de transporte; en la segunda parte se proponen soluciones para cada uno de los principales problemas encontrados en los aspectos considerados y en la tercera parte se hace la especificación de las principales características técnicas de tres (3 buses tipo o patrón en los tamaños mediano y grande de acuerdo con las normas internacionales. El estudio se complementa con un programa de mantenimiento y con cuatro (4 modelos matemáticos sobre comportamiento mecánico de los buses.

  20. Comorbidades médicas em pacientes ambulatoriais com transtorno do humor bipolar tipo I

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    Camila Luzia Roganti Leite Moreira

    2011-01-01

    Full Text Available CONTEXTO: O transtorno do humor bipolar (THB está associado a altas taxas de comorbidades médicas gerais (CMGs e fatores de risco para problemas médicos, porém há escassos relatos sobre a prevalência dessas condições em brasileiros com THB. OBJETIVO: Descrever a prevalência de CMGs em uma amostra de pacientes com THB tipo I. MÉTODOS: Dados clínicos de 195 pacientes com THB tipo I foram revisados para identificação de CMGs. Pacientes com e sem CMGs foram comparados usando o teste não paramétrico Mann-Whitney e o teste qui-quadrado. RESULTADOS: Sessenta e três por cento dos pacientes relataram pelo menos uma comorbidade médica. As condições mais prevalentes foram: enxaqueca (31,8%, hipotireoidismo (24,1%, hipertensão (11,3%, traumatismo craniano (10,3%, asma (9,7%, epilepsia (8,2%, diabetes (5,1%, acidente vascular cerebral (2,1% e hipertireoidismo (1%. Idade e duração da doença foram positivamente associadas à presença de CMGs (p < 0,001. CONCLUSÃO: Em concordância com relatos prévios, a maioria dos pacientes apresentou pelo menos uma doença médica. A principal limitação deste estudo reside no fato de o diagnóstico de CMGs ter sido baseado no autorrelato. Há escassos estudos visando à identificação de comorbidades médicas na população brasileira com THB e este estudo pode contribuir para melhor vigilância diagnóstica, avaliação, tratamento e diminuição da sobrecarga associada ao THB.

  1. Autopsia verbal en hombres adultos con diabetes tipo 2: estudio cualitativo

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    Geu Mendoza-Catalán

    2017-09-01

    Full Text Available Introducción: La diabetes mellitus tipo 2 (DMT2 es un padecimiento crónico cuya incidencia se incrementa en forma alarmante. El objetivo fue identificar los factores asociados al no autocuidado en hombres con muerte prematura y diagnóstico de DMT2. Materiales y Métodos: Se realizaron seis entrevistas cualitativas a familiares de hombres con DMT2 que fallecieron por complicaciones de su enfermedad, utilizando la metodología de la autopsia verbal. Los resultados se analizaron mediante el análisis de contenido. Resultados: Dentro de los factores que surgieron como limitantes para el autocuidado fueron: la negación de la DMT2, el trabajo, el machismo, preferencia en los alimentos, apoyo familiar, el consumo de alcohol, el consumo de tabaco y la depresión. Discusión: Los hombres con DMT2 se ven influenciados por diversas circunstancias que limitan cuidarse, atenderse y por consiguiente presentar desventajas de salud, complicaciones e incluso una muerte temprana. Conclusiones: Desde la perspectiva de enfermería los resultados ayudan a comprender el comportamiento de los hombres ante esta enfermedad en donde se requiere cuidado constante, a la par que una conciencia legítima de que no se deja de ser hombre por cuidarse.  Cómo citar este artículo: Mendoza-Catalán G, Gallegos-Cabriales EC, Figueroa-Perea JG. Autopsia verbal en hombres adultos con diabetes tipo 2: estudio cualitativo. Rev Cuid. 2017; 8(3: 1786-98. http://dx.doi.org/10.15649/cuidarte.v8i3.420

  2. Tipos de hogar, ciclo de vida familiar y pobreza en Costa Rica 1987-2002

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    Barquero, Jorge

    2004-07-01

    Full Text Available El propósito de este estudio fue el de explorar las condiciones vulnerabilidad sociodemográfica en Costa Rica, a partir del análisis de los cambios en los tipos de hogar y el ciclo de vida de las familias en condiciones de pobreza, utilizando información de las Encuestas de Hogares de 1987, 1994 y 2002. Los principales hallazgos revelan modificaciones importantes en la estructura y composición de los hogares y familias en el periodo de estudio, asociado a cambios en la dinámica sociodemográfica de la sociedad costarricense. La evolución en la incidencia de la pobreza por tipo de hogar muestra que ésta es mayor entre los hogares nucleares que cuentan con hijos y al convertirse en monoparentales. La incidencia es más alta en 1987, se reduce para 1994 y prácticamente se mantiene para el 2002. No obstante que en todas las fases del ciclo de vida familiar la incidencia de la pobreza disminuyó en el periodo 1987-1994, en el periodo más reciente al 2002 la incidencia es mayor en las etapas en que las familias poseen más hijos dependientes menores de 18 años, lo que expone a estas familias a una mayor vulnerabilidad a situaciones de pobreza. Los hogares y familias con mayor riesgo de vulnerabilidad ante la pobreza, se hallaron entre aquellos con mayor cantidad de miembros dependientes menores de edad y jefeados por mujeres. No se encontraron evidencias significativas para afirmar que el estancamiento observado en los niveles de pobreza en el país hasta el 2002, fuese producto de los cambios encontrados en los patrones familiares, aunque ciertamente se hace necesario profundizar el análisis de las interrelaciones entre pobreza y cambios demográficos.

  3. Caracterización del inicio de la diabetes mellitus tipo 1 en menores de 18 años

    OpenAIRE

    Yan González Ramos; Milenis Acosta Fonseca; Elizabeth Ríos Alberdi; Annia Quintana Marrero; Aymé Marrero Gil

    2016-01-01

    Fundamento: la diabetes mellitus tipo 1 es la enfermedad crónico endocrinológica más frecuente en la edad pediátrica y la segunda enfermedad crónica en la infancia después del asma bronquial, en los países desarrollados. Objetivo: identificar los aspectos epidemiológicos en el inicio de la diabetes mellitus tipo 1 en menores de 18 años en la provincia de Cienfuegos en el periodo 1997- octubre 2015. Métodos: se realizó un estudio descriptivo retrospectivo en los pacientes menores de 18 años, d...

  4. Ejercicio físico, calidad de vida y salud de diabéticos tipo 2

    OpenAIRE

    Silva, Franciele Cascaes

    2017-01-01

    El objetivo de este estudio fue comparar los efectos de diferentes tipos de ejercicios físicos, desarrollados durante 24 semanas, relacionados con la calidad de vida y salud de individuos con diabetes mellitus tipo 2. Fueron seleccionados 24 individuos inactivos de ambos sexos, con un promedio de edad de 60.41 años. Los individuos fueron divididos aleatoriamente en tres grupos: ejercicio aeróbico, ejercicio resistido y ejercicio de flexibilidad. Los instrumentos utilizados fueron una ficha de...

  5. MODELAGEM COMPUTACIONAL DO MÉTODO DE CISALHAMENTO DIRETO COM CONECTOR TIPO PINO COM CABEÇA

    OpenAIRE

    Reis Sales, Marcel Willian; Pereira Júnior, Wanderlei Malaquias; Borja Ferreira, Diego; Mikulaschek, Adriana

    2015-01-01

    Diversos tipos de lajes podem ser usados em estruturas mistas de aço concreto. Entretanto, a laje alveolar é uma boa solução, pois ela reduz a necessidade de escoras permitindo que a estrutura de concreto seja executada com velocidade compatível à estrutura metálica. Este trabalho apresenta uma discussão da ligação de cisalhamento promovida em vigas mistas de aço concreto, por conectores tipo pino com cabeça. A ligação é feita pelo conector e preenchida com concreto, podendo existir ou não ar...

  6. Tipos de incontinencia urinaria en personas mayores de 65 años institucionalizadas: tratamiento y cuidados

    OpenAIRE

    García Hernández, Misericordia

    2013-01-01

    El presente estudio analiza la prevalencia de incontinencia urinaria en personas mayores de 65 años, institucionalizadas en centros socio-sanitarios, en unidades de larga estancia, y residencias públicas de Cataluña; así como los tipos de incontinencia y el abordaje de la misma. También se analiza la relación entre incontinencia, tipo, abordaje y la presencia o no de dependencia física y/o alteración cognitiva, mediante un estudio descriptivo e inferencial. Los resultados obtenidos nos de...

  7. Evaluación del modelo experimental de tipo tutorial en la autoestima de los adolescentes del medio rural

    OpenAIRE

    Zevallos Mendoza, Guillermo Antonio

    2005-01-01

    El presente trabajo de investigación denominado: "Evaluación del Modelo Experimental de Tipo Tutorial en la Autoestima de los Adolescentes del Medio Rural" se ejecutó en la ciudad de llave teniendo como una muestra intencionada de 300 adolescentes del medio rural del quinto de secundaria, teniendo como centro de operaciones la E.E.P. "Mariano Zevallos". Dicho grupo de adolescentes fueron sometidos experimentalmente dentro del modelo, a un trabajo de ejecución de 10 tipos de diseños tutoriales...

  8. NEUMOTÓRAX ESPONTÁNEO ASOCIADO A FIBROSIS PULMONAR EN UN PACIENTE CON NEUROFIBROMATOSIS TIPO 2

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    Gabriel Alcalá Cerra

    2010-04-01

    Full Text Available El compromiso pulmonar en pacientes con neurofibromatosis ha sido reiteradamente descrito como una complicación muy rara en la variedad tipo 1. Se caracteriza por enfermedad pulmonar intersticial difusa, fibrosis pulmonar, neoplasias torácicas y formación de bulas, estas últimas, con alto riesgo de ruptura. Describimos un caso de neumotórax espontáneo en una paciente con neurofibromatosis tipo 2, como consecuencia de cambios fibróticos pulmonares. A nuestro conocimiento, esta asociación no había sido reportada.

  9. Experiencia de producción de lechuga americana (Lactuca sativa hidropónica, tipo NFT

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    Laura Brenes-Peralta

    2014-06-01

    En el Centro de Prácticas Docentes e Investigación Agropecuaria de la Escuela de Agronegocios del Instituto Tecnológico de Costa Rica (TEC se cuenta, actualmente, con un sistema de este tipo NFT donde estableció una actividad de fortalecimiento que ha resultado en la observación de ciertas características a partir de la experiencia generada, de la cual se espera fomentar el uso de la hidroponía, así como divulgar información técnica y de buenas prácticas en este tipo de cultivo entre usuarios interesados.

  10. Avaliação dos tipos de glaucoma no serviço de oftalmologia da UNICAMP

    OpenAIRE

    Urbano, Andréia Peltier; Freitas, Telma Gondim; Arcieri, Enyr Saram; Urbano, Alessandra Peltier; Costa, Vital Paulino

    2003-01-01

    p.61-65 Objetivo: Avaliar a freqüência dos tipos de glaucoma no Setor de Glaucoma do Hospital das Clínicas da Universidade Estadual de Campinas. Métodos: Estudo transversal de 329 pacientes atendidos no Setor de Glaucoma da Universidade Estadual de Campinas entre 1 de outubro e 20 de dezembro de 2000, com avaliação dos tipos de glaucoma e conduta terapêutica. Resultados: De 329 pacientes atendidos no Ambulatório de Glaucoma, 132 foram encaminhados ao ambulatório por suspeita de glaucoma (4...

  11. Avaliação dos tipos de glaucoma no serviço de oftalmologia da UNICAMP

    OpenAIRE

    Urbano,Andréia Peltier; Freitas,Telma Gondim; Arcieri,Enyr Saram; Urbano,Alessandra Peltier; Costa,Vital Paulino

    2003-01-01

    OBJETIVO: Avaliar a freqüência dos tipos de glaucoma no Setor de Glaucoma do Hospital das Clínicas da Universidade Estadual de Campinas. MÉTODOS: Estudo transversal de 329 pacientes atendidos no Setor de Glaucoma da Universidade Estadual de Campinas entre 1 de outubro e 20 de dezembro de 2000, com avaliação dos tipos de glaucoma e conduta terapêutica. RESULTADOS: De 329 pacientes atendidos no Ambulatório de Glaucoma, 132 foram encaminhados ao ambulatório por suspeita de glaucoma (40,1%) e 197...

  12. Enfermedad periodontal en pacientes diabéticos tipo 2 con y sin obesidad en Lima, Perú

    OpenAIRE

    Quezada Carrera, José Carlos; Sacsaquispe Contreras, Sonia; Gutiérrez Ventura, Fredy; del Castillo López, César; López Pinedo, Martha

    2016-01-01

    Objetivos: Determinar si la enfermedad periodontal afecta más a pacientes diabéticos tipo 2 con obesidad que a  los pacientes sin obesidad. Material y métodos: La población estuvo conformado por 170 pacientes con diagnósticode Diabetes Mellitus (DM) tipo 2; fueron divididos en dos grupos 85 diabéticos obesos y 85 diabéticos no obesos: el grupo obesos fue de 55 mujeres y 30 hombres mientras que el grupo sin obesidad fue de 37 mujeresy 48 hombres. Se utilizó el Índice Periodontal Comunitario Mo...

  13. Diseño de un aerogenerador de eje vertical tipo Savonius para electrificación rural

    OpenAIRE

    Arbeloa Sola, Lorena

    2012-01-01

    Este proyecto fin de carrera describe el cálculo y el diseño de un aerogenerador de eje vertical tipo Savonius para electrificación rural aprovechando la energía del viento. El objeto de este proyecto es proporcionar toda la información necesaria para la construcción e instalación de un aerogenerador de este tipo en una comunidad boliviana, concretamente en la comunidad de Vilacollo, situada en el departamento de Oruro, en la parte oeste de Bolivia. Si dicho proyecto resulta e...

  14. Niveles de cortisol salival y tipos de personalidad de Grossarth-Maticek y Eysenck: un estudio transcultural

    OpenAIRE

    Camacho-Gutiérrez, Everardo; Vega-Michel, Claudia; Orejudo-Hernández, Santos

    2012-01-01

    Basándonos en la tipología de personalidad de Grossarth-Maticek y Eysenck que relaciona ciertos tipos de personalidad con el padecimiento de enfermedades, en esta investigación se analiza en dos muestras de estudiantes universitarios mexicanos y españoles la relación entre el tipo de personalidad de propensión al cáncer y el de propensión a las enfermedades cardiovasculares y el consumo de tabaco y los niveles de cortisol salival. Un total de 190 estudiantes mexicanos y españoles respondieron...

  15. A Qualitative, Comparative Study of the Use of Electronic Information and Other Services at Universitäts- und Landesbibliothek Münster

    Directory of Open Access Journals (Sweden)

    John C. Crawford

    1999-05-01

    Full Text Available The Universitäts- und Landesbibliothek, (ULB Münster, has a substantial background of research and publication in performance measurement and evaluation of library and information services (Poll and te Boekhorst and has conducted and published internal studies of various aspects of its services.(Obst 1995; Buch 1996. My contact with the Library goes back to late 1996 when I spent two weeks at ULB on a British Council exchange scheme with North Rhine Westphalia which gave me some understanding of how the Library operates and some knowledge of the technical vocabulary of German academic librarianship. In 1998 I directed a qualitative study of the use being made of Glasgow Caledonian University Library’s recently opened Electronic Information Floor (Crawford 1999. A literature review undertaken prior to the study showed that surprisingly little research had been done in this area and that one of the earliest studies was that undertaken by Dr Oliver Obst at Münster (1995. Coincidentally ULB is a partner in the EQUINOX Project, led by CERLIM, which aims to develop a set of standardised performance measures for the electronic library and was interested in collecting some qualitative data as a background to the Project. After email discussions with ULB it was decided that I should visit the Library again to undertake a qualitative study of the use of electronic information services there which would act both as a comparative study with Glasgow Caledonian University and a background study to the much larger, CERLIM led, EQUINOX Project.

  16. Influence of ecological factors on the production of active substances in the anti-cancer plant Sinopodophyllum hexandrum (Royle T.S. Ying.

    Directory of Open Access Journals (Sweden)

    Wei Liu

    Full Text Available The quality of traditional Chinese herbal medicine, which plays a very important role in the health system of China, is determined by the active substances produced by the plants. The type, content, and proportion of these substances may vary depending on ecological factors in areas where the plants are grown. Sinopodophyllum hexandrum (Royle T.S. Ying, an endangered plant species with great medical value, was investigated in eight production locations representative of its natural geographical distribution range in China. The correlation between the contents of the active ingredients extracted from the roots and rhizomes of S. hexandrum and the ecological factors were evaluated step-by-step using a series of computational biology methodologies. The results showed that ecological factors had significant effects on the contents but not on the types of the active ingredients in eight production locations. The primary ecological factors influencing the active substances included the annual average precipitation, July mean temperature, frost-free period, sunshine duration, soil pH, soil organic matter, and rapidly available potassium in the soil. The annual average precipitation was the most important determinant factor and was significantly and negatively correlated with the active ingredient contents (P < 0.001. In contrast, organic matter was the most important limiting factor and was significantly and positively correlated with the active substances. These ecological factors caused 98.13% of the total geographical variation of the active ingredient contents. The climate factors contributed more to the active ingredient contents than did the soil factors. It was concluded that from the view of the contents of the secondary metabolites and ecological factors of each growing location, in Jingyuan, Ningxia Province, and Yongdeng, Gansu Province, conditions were favorable to the production of podophyllotoxin and lignans, whereas in Shangri-La, Yunnan

  17. Tsé na'alkaah: Weaving Native and Mainstream Earth and Environmental Science into Place-Based Teacher Professional Development on the Colorado Plateau

    Science.gov (United States)

    Semken, S. C.; Godsey, H. S.; Tsosie, W. B., Jr.

    2017-12-01

    Place-based, culturally-integrated approaches to teaching geoscience and environmental science are aligned with traditional indigenous education, and illustrate the premise that leveraging the cultural capital of Native Americans and other underrepresented groups renders more inclusive and relevant teaching. Situating learning within local landscapes, environments, and communities; and meaningfully connecting mainstream science with Native science and knowledge of place enables students to construct new knowledge that is scaffolded by their own worldview and experiences, and helps lessen any sense of discontinuity that may arise from apparently disparate interpretations of Earth processes. We drew on this philosophy in implementing a multi-year program of summer professional-development workshops for K-12 teachers in the Colorado Plateau and Intermountain regions, many of whom work in schools that serve majority Native American student populations. Through collaboration of geoscientists, Diné (Navajo) cultural experts, and master teachers, we developed and implemented inquiry-rich field excursions in which learning about Earth-system features and processes on the Plateau utilized factual and conceptual knowledge from mainstream geoscience and Diné geoscience (tsé na'alkaah) alike, as well as on other forms of local place knowledge such as Diné toponymy and history. Participants used concepts such as the dynamic interactions of Earth (Nahasdzaan) and Sky (Yádilhil) systems and the natural order (nitsahakees, nahat'a, iina, siihasin) to interpret natural landscape features (e.g., desert landforms, Plateau stratigraphy, Laramide structures) as well as anthropogenic impacts (e.g., uranium extraction and its environmental and health effects) in the field. We will share specific examples of place-based, culturally integrated curriculum and assessment from this program.

  18. Diabetes mellitus tipo 1 na ausência de neuropatia autonômica não altera a taxa de sudorese no exercício Type 1 diabetes mellitus in the lack of autonomic neuropathy does not alter the sudoresis rate in exercise

    Directory of Open Access Journals (Sweden)

    Cristiane Martins Rocha

    2009-02-01

    Full Text Available A sudorese é o principal mecanismo autonômico termorregulatório na espécie humana. A taxa de sudorese (TS durante o exercício pode ser influenciada por diversos fatores, entre eles doenças, como o diabetes mellitus tipo 1, cujos pacientes são vítimas potenciais de distúrbios termorregulatórios. Os exercícios regulares são recomendados para diabéticos e, inclusive, alguns deles tornam-se atletas. No entanto, ainda não foi medida a TS de diabéticos durante exercício progressivo até a exaustão (GXT e comparada com a de indivíduos sadios com características antropométricas semelhantes. O presente estudo comparou a TS de sete voluntários diabéticos (DM e sete controles (GC, semelhantes quanto à idade, gênero, composição corporal e capacidade aeróbica. Antes e após o GXT, foram medidos a gravidade específica da urina (GEU, o peso e a glicemia capilar. A TS global foi calculada dividindo-se a variação do peso pelo tempo de coleta e área de superfície corporal. A TS local do antebraço foi calculada utilizando-se a variação do peso de um filtro absorvente corrigido pela sua área e tempo de coleta. As TS locais do antebraço e da perna foram induzidas por iontoforese com pilocarpina (0,5% no grupo DM. A freqüência cardíaca (FC foi registrada antes, durante e após GXT. A temperatura média da pele (TMP e as condições térmicas ambientais foram medidas durante o experimento. A glicemia capilar foi maior no DM, como o esperado. As TS global e local foram semelhantes entre os grupos, enquanto que a FC no repouso e a TMP no repouso e no exercício foram maiores no DM. Não houve diferença entre as TS do antebraço e da perna no DM com a pilocarpina. Concluiu-se que a resposta sudorípara foi semelhante entre diabéticos jovens e grupo controle durante exercício progressivo em ambiente temperado.Sudoresis is the main autonomic human thermoregulatory mechanism. It can be influenced by several factors, including

  19. Potencial de vida útil pós-colheita de quatro genótipos de melão tipo Galia Potential of postharvest shelf life of four genotypes of Galia type melons

    Directory of Open Access Journals (Sweden)

    Patrícia Lígia Dantas de Morais

    2004-12-01

    Full Text Available Avaliou-se o potencial de vida útil pós-colheita de melões (Cucumis melo L. tipo Galia (genótipos Primal, Solarking, Total e Vicar. Utilizou-se o delineamento inteiramente casualizado em esquema fatorial 4 (genótipos x 4 (tempos de armazenamento: 0, 3, 6 e 9 dias, com três repetições. Os frutos foram colhidos no estádio de maturação IV (predominantemente amarelo e armazenados à temperatura de 20 ± 1ºC e umidade relativa de 50 ± 2%. O genótipo Solarking apresentou uma firmeza média de polpa superior aos demais, do inicio ao final do período de armazenamento. Em todos os genótipos, os valores de sólidos solúveis no início do armazenamento encontraram-se dentro da faixa aceitável para comercialização no mercado externo, havendo pouca variação com o decorrer do período de armazenamento. A aparência interna limitou o tempo de vida útil pós-colheita do genótipo Total em apenas seis dias. Os genótipos Solarking, Vicar e Primal apresentaram maior potencial na conservação pós-colheita, principalmente o híbrido Solarking, que chegou aos nove dias de armazenamento com boa aparência interna.The postharvest life span of Galia (genotypes Primal, Solarking, Total, and Vicar melons (Cucumis melo L. was evaluated by a four (genotypes x four (storage periods: 0, 3, 6, and 9 days factorial experiment, in a completely randomized design with three replications. The fruits were harvested at maturation stage IV (yellow color predominance, and stored under 20 ± 1ºC and HR 50 ± 2%. Solarking's average firmness was better than that of the other genotypes during the experimental period. At the beginning of the experiment all genotypes had soluble solids contents at the level (eight to ten percent required for exportation, with these levels varying slightly during storage. The internal aspect limited to six days the postharvest life span of genotype Total. Solarking, Vicar, and Primal showed great postharvest conservation potential

  20. Tipos de vegetación del llano de Paletará. Cordillera Central Colombia Tipos de vegetación del llano de Paletará. Cordillera Central Colombia

    Directory of Open Access Journals (Sweden)

    Restrepo Carla

    1992-09-01

    Full Text Available We studied the vegetation found in the Llano de Paletará, municipality of Coconuco, department of Cauca, Colombia. Based on the physiognomy and floristic composition of the vegetation we identified 8 paramo vegetation types. These units represent the most extensive azonal paramo vegetation types described up to now for the Cordillera Central. Four of the 8 vegetation types are herbaceous ("frailejonal-pajonal" with Espeletia, "chuscal abierto" with Chusquea,"swamp" with Carex, and "grassland" with Calamagrostis , three are bush tickets (thicket with Hypericum, thicket with Ageratina, and thicket with Diplostephium, and one is a forest of low stature (forest with Escallonia. We analyze some aspects of the ecology and distribution of the vegetation types and evaluate their degree of peril and value of conservation. Se estudiaron los tipos de vegetación del Llano de Paletará, municipio de Coconuco, departamento del Cauca, Colombia. Basados en la fisonomía y composición florística de la vegetación identificamos 8 tipos de vegetación, los cuales representan los tipos de vegetación paramunos de carácter azonal más extensos de la Cordillera Central registrados hasta el momento. De los 8 tipos de vegetación, cuatro son de porte herbáceo (''frailejonalpajonal'' con Espeletia. "chuscal abierto" con Chusquea. "pantano" con Carex y un "pajonal" con Calamagrostis, tres son de porte arbustivo (matorral con Hypericum, matorral con Ageratina y matorral con Diplostephium y uno es de porte arbóreo (bosque con Escallonia. Se analizan algunos aspectos de la ecología y distribución de los tipos de vegetación y se evalúa su grado de amenaza y valor de conservación.

  1. Influence of different kinds of rosins and hydrogenated resins on the setting time of Grossman cements Influência de diferentes tipos de breus e resinas hidrogenadas sobre o tempo de endurecimento dos cimentos do tipo Grossman

    Directory of Open Access Journals (Sweden)

    Manoel Damião SOUSA NETO

    1999-01-01

    Full Text Available In this study, the effect on the setting time by the addition of different kinds of rosin and hydrogenated resin on the Grossman cement powder was evaluated. The experiments were carried out following the American Dental Association’s specification number 57 for root canal sealers. For this analysis, different Grossman cement powders were prepared using different rosins (X, WW and WG and hydrogenated resins (Staybelite and Staybelite ester 10. The study of the physicochemical properties of the Grossman cements obtained the different kinds of rosins and hydrogenated resins interference on the cement’s setting time. The hydrogenated resin, having a higher pH, increased the setting time of the cement when compared to the X, WW and WG rosins.No presente estudo, analisou-se o efeito da adição de diferentes tipos de breus e resinas hidrogenadas ao pó do cimento de GROSSMAN sobre o tempo de endurecimento. Os experimentos foram realizados de acordo com a Especificação 57 para materiais obturadores de canais radiculares da American Dental Association (ADA. Para análise, foram aviados pós do cimento de GROSSMAN com diferentes tipos de breu (X, WW e WG e resinas hidrogenadas (Stabylite e Stabylite éster 10. Os estudos das propriedades físico-químicas dos cimentos tipo GROSSMAN obtidos de diferentes tipos de breus e resinas hidrogenadas interferem no tempo de endurecimento do cimento. A resina hidrogenada, obtida do processo de hidrogenação tem o pH mais alto, provocando um aumento do tempo de endurecimento do cimento em relação aos breus tipo X, WW e WG, que têm pH mais ácido.

  2. Paciente con deficiencia de adhesión leucocitaria tipo 1 y doble falla primaria de injerto

    OpenAIRE

    Alberto Olaya-Vargas; Lilia Vollbrechausen-Castelán; Celso Tomás Corcuera-Delgado; Selma Scheffler-Mendoza

    2015-01-01

    Niño de 4 años de edad con diagnóstico de deficiencia de adhesión leucocitaria tipo 1, postrasplantado de células progenitoras hematopoyéticas en tres ocasiones, las dos primeras con falla primaria de injerto.

  3. Suscetibilidade de genótipos de feijão ao vírus-do-mosaico-dourado

    Directory of Open Access Journals (Sweden)

    Lemos Leandro Borges

    2003-01-01

    Full Text Available O objetivo deste trabalho foi avaliar a suscetibilidade de diversos genótipos de feijão ao vírus-do-mosaico-dourado (VMDF, transmitido pela mosca branca (Bemisia tabaci. A semeadura foi realizada na época da seca e das águas, com e sem aplicação do inseticida granulado Aldicarb (3,0 kg ha-1 do i.a. no sulco de semeadura. O delineamento experimental utilizado foi o de blocos casualizados disposto em esquema fatorial 14x2, representado por genótipos e inseticida, respectivamente, com quatro repetições. A maior infestação de mosca-branca e incidência do vírus ocorreu na época da seca, causando prejuízos à produção do feijoeiro. Os genótipos apresentaram diferentes graus de suscetibilidade ao vírus e ao inseto vetor. Os genótipos mais tolerantes foram IAPAR 57, IAPAR 65, IAPAR 72, Ônix, Aporé e 606 (5(214-17. A aplicação do inseticida sistêmico controla o vetor em ambas as épocas de cultivo, proporcionando aumentos da produtividade.

  4. El tipo antropológico migratorio mediterráneo: ciudadanía a medias

    Directory of Open Access Journals (Sweden)

    Fernando de Lucas y Murillo de la Cueva

    2010-10-01

    político y mediático. En cambio, el establecimiento de una política migratoria, declarada según el tipo de sociedad que quiera construirse, puede llevar a una mejora y un desarrollo real de la ciudadanía para todos y todas.

  5. Construção de cartilha sobre insulinoterapia para crianças com diabetes mellitus tipo 1

    Directory of Open Access Journals (Sweden)

    Denizielle de Jesus Moreira Moura

    Full Text Available RESUMO Objetivo: descrever o processo de construção de uma cartilha educativa sobre insulinoterapia para crianças com diabetes mellitus tipo 1. Método: abordagem metodológica, na qual se seguiram as etapas: seleção do conteúdo e tipo de tecnologia a ser construída (para essa etapa, foi realizada revisão integrativa, análises dos comentários de blogs sobre Diabetes Mellitus tipo 1 e entrevista com as crianças, criação de imagens, diagramação e composição do layout. Resultados: o trabalho resultou na produção da versão final da cartilha educativa, que teve como título Aplicando a insulina: a aventura de Beto. O processo de construção da cartilha foi embasado na participação ativa das crianças e norteado pelo referencial teórico do Construtivismo Piagetiano. Conclusão: o recurso é facilitador para a melhoria do conhecimento e das práticas de autocuidado de crianças com Diabetes Mellitus tipo 1.

  6. UM OLHAR SOBRE O DIABETES NA INFÂNCIA E NA JUVENTUDE: NEM TODOS SÃO TIPO 1

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    ANGHEBEM-OLIVEIRA

    2013-12-01

    Full Text Available O Diabetes mellitus (DM é caracterizado como um quadro de hiperglicemia crônica, que com os anos causa disfunção endotelial e sérias complicações vasculares, como a retinopatia, nefropatia e o infarto agudo do miocárdio. À medida que a ciência avança na compreensão da fisiopatologia e das características clínico-laboratoriais do diabetes, sua classificação tem sido adaptada, justamente porque a correta classificação do diabetes vai impactará no prognóstico e tratamento do paciente. Atualmente, o diabetes é classificado em DM tipo 1, DM tipo 2, DM gestacional e Outros Tipos Específicos, que inclui a categoria MODY (do inglês, Maturity Onset Diabetes of the Young ou diabetes da maturidade com início na juventude. O que esta revisão pretende mostrar é quem nem todo diabetes diagnosticado na infância e na juventude é DM tipo 1

  7. Percepción del consumidor sobre los tipos de carne picada que se comercializan en Montevideo

    Directory of Open Access Journals (Sweden)

    Laura María Raggio

    2014-12-01

    Full Text Available La técnica de asociación de palabras fue utilizada para realizar un estudio preliminar de la percepción sobre los tipos de carnes picadas comercializadas en Montevideo. 60 consumidores recibieron cinco tarjetas con las palabras: Carne Picada Común, Magra, Premium, de Ternera y Especial y se les solicitó que escribieran las cuatro primeras imágenes, asociaciones, pensamientos o sentimientos que vinieran a su mente al leer cada tarjeta. Posteriormente, evaluaron cuán saludable consideraban que era cada tipo de carne picada. Las respuestas fueron agrupadas en 16 categorías. La Carne Picada Común fue percibida como un alimento con alto contenido de grasa y evaluada como poco saludable. Las carnes picadas Magra y Premium fueron percibidas como productos con bajo contenido graso, nutritivas, saludables y de precio elevado. La tipo Premium fue considerada, además, como un producto de calidad. La carne picada de Ternera fue percibida principalmente como un producto con una textura tierna, suave y blanda, mientras que en la carne picada Especial se encontraron contradicciones en las palabras utilizadas por los consumidores para su descripción (cara-económica, con poca grasa- con mucha grasa. Por medio de esta técnica se identificaron los atributos más relevantes en el proceso de selección y toma de decisiones de compra de este tipo de producto.

  8. Paciente con deficiencia de adhesión leucocitaria tipo 1 y doble falla primaria de injerto

    Directory of Open Access Journals (Sweden)

    Alberto Olaya-Vargas

    2015-11-01

    Full Text Available Niño de 4 años de edad con diagnóstico de deficiencia de adhesión leucocitaria tipo 1, postrasplantado de células progenitoras hematopoyéticas en tres ocasiones, las dos primeras con falla primaria de injerto.

  9. Diabetes tipo 2, obesidad y cetoacidosis diabética en niños.: Reporte de caso

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    Helard Manrique

    2011-07-01

    Full Text Available Se reporta el caso de una niña con obesidad que acudió a nuestro hospital por presentar cetoacidosis diabética. El manejo inicial incluyó hidratación enérgica e insulina endovenosa. El análisis de anticuerpos anti-GAD fue negativo y el péptido C fue normal. El control metabólico a largo plazo fue con metformina, dieta y ejercicio.Tradicionalmente, la diabetes tipo 2 ha sido considerada una enfermedad de adultos. Sin embargo, a medida que aumenta la prevalencia de obesidad en niños, aumenta el número de casos de diabetes tipo 2 en este grupo etáreo. La hiperglicemia sostenida puede deteriorar la secreción de insulina por parte de las células beta del páncreas. Este fenómeno, llamado glucotoxicidad, puede explicar porque algunos pacientes con diabetes tipo 2 presentan cetoacidosis diabética. No todos los niños que debutan con cetoacidosis diabética tienen diabetes tipo 1.(Rev Med Hered 2011;22:139-142.

  10. Enfermedad de Niemann Pick tipo-A. Presentación de 12 casos

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    Jorge Zarco-Román

    2017-05-01

    Full Text Available INTRODUCCIÓN: la enfermedad de Niemann Pick tipo A es una enfermedad hereditaria de depósito lisosomal, debida a un déficit de la enzima esfingomielinasa ácida, lo que da lugar a la acumulación de esfingomielina en las células del sistema reticuloendotelial y nervioso central. OBJETIVO: se describe el curso de la enfermedad de Niemann Pick tipo A en 12 pacientes: tres niños y nueve niñas, con edades entre 3 a 33 meses. MATERIAL Y MÉTODOS: estudio retrospectivo efectuado con base en la información de los expedientes de 12 pacientes, evaluados mediante un examen físico completo, oftalmológico, análisis de laboratorio, ultrasonido de abdomen, tomografía axial computarizada o resonancia magnética nuclear cerebral, radiografías de tórax, ecocardiograma, electroencefalograma, potenciales evocados auditivos y visuales, serie esofagogastroduodenal y serie ósea. Se obtuvo información sobre enfermedades intercurrentes y causas de muerte. RESULTADOS: la sintomatología comenzó en promedio a los 5.9 meses (2 a 16 meses y el diagnóstico definitivo se realizó a la edad de los 15.6 meses (3 a 33 meses a través del cuadro clínico sugestivo, con presencia de células espumosas en el aspirado de médula ósea 12/12 (100% y deficiencia de la enzima esfingomielinasa ácida en 12/12 pacientes (100%; la biopsia hepática fue sugestiva de enfermedad por atesoramiento en 5/12 (41.6%. Las manifestaciones clínicas por orden de frecuencia fueron: hepatoesplenomegalia y afección neurológica en 12/12 (100%, alteración pulmonar 11/12 (91.6%, hematológica 9/12 (80%, oftalmológica con mancha rojo cereza 9/12 (75%, ósea 6/12 (50%, y cardiaca 4/12 (33.3%. Únicamente hubo antecedente de consanguinidad en 4 familias (33.3%. CONCLUSIONES: el curso clínico de la enfermedad de Niemann Pick tipo A es muy similar entre los pacientes afectados, el primer dato clínico detectado es la hepatoesplenomegalia. Los pacientes están asintomáticos los primeros

  11. Inmunogenética e inmunopatología de la diabetes insulinodependiente tipo I

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    Gloria Garavito

    2005-01-01

    Full Text Available La diabetes insulinodependiente tipo I (T1D es una enfermedad crónica y autoinmune que altera la calidad de vida en niños desde muy temprana edad. Esta patología genera un alto costo para la salud pública y produce trastornos psicoafectivos en el núcleo familiar disminuye los años de vida productiva y los años de vida saludable. La diabetes mellitus tipo I o insulinodependiente tiene una prevalencia muchísimo menor que la diabetes tipo 2 o no dependiente de insulina. Sin embargo, sus secuelas crónicas debido a la microangiopatía, macroangiopatía y neuropatías producen una elevada morbimortalidad en los pacientes que la padecen. El análisis molecular revela que los loci DQA1 y DQB1 se encuentran fuertemente asociados con susceptibilidad y resistencia a la expresión de T1D. La asociación con susceptibilidad más documentada ha sido con los haplotipos DQB1*O3O2 – DQA1* 0301 y DQB1*0201 – DQA1*0501, ambos asociados a los antígenos DR4 y DR3 respectivamente. Un estudio realizado en poblaciones de Ciudad de México, Caracas y Medellín concluyó que existe significancia estadística para considerar a los alelos DQA1 como marcadores de susceptibilidad para el desarrollo de T1D. En otro estudio realizado en pacientes norteamericanos de origen mexicano se encontró que los alelos DQB1*0302 DQB1*0201 se encontraban en un 91% de los pacientes comparados con el 67% de los controles, y los alelos DQA1*0501 y DQA1*0301 en el 100% de los pacientes comparado con el 74% de los controles. En estudios previos realizados por nuestro grupo informamos la caracterización molecular de genes HLA clase II por medio de la técnica PCR-SSP en una población de pacientes mestizos en el litoral caribe de Colombia. Analizamos los loci: HLA DRB1 y HLA DQB1. Los alelos con mayor expresión en controles sanos en el locus DQB1 fueron: HLA-DQB1*0301, con Gloria Garavito, Kelly Del Toro, Eduardo Egea B, Eduardo Enrique Egea, Elkin Navarro INTRODUCCIÓN un 23

  12. Rhabdoid choroid plexus carcinoma: a rare histological type Carcinoma de plexus coroides de tipo rabdoide: un tipo histológico raro

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    Martha Lilia Tena-Suck

    2007-09-01

    Full Text Available Primary central nervous system atypical teratoid/rhabdoid tumors mostly occur during early childhood and are almost invariably fatal. These tumors show similar histological and radiological features to primitive neuroectodermal tumor, meduloblastoma and choroid plexus carcinoma, but present different biological behaviors. We present the case of an 18 year-old man who presented headache, vomiting and ataxia. CT-scan and MRI revealed a posterior fossa tumor. A gross total resection was performed. An intraoperative study showed papillary-like tumors with large cells and mitotic features. Histological examination showed two different main growth patterns: solid sheets of undifferentiated polygonal cells with papillary features and rhabdoid cells. Immunohistochemically, these rhabdoid cells were positive for vimentin, epithelial membrane antigen, smooth-muscle actin, cytokeratin, S-100 protein, and glial fibrillary acidic protein. Electro-microscopically, the typical rhabdoid cells contained whorled bundles of intermediate filaments in their cytoplasm. A rhabdoid tumor is a clinicalpathological entity and emphasizes the necessity to distinguish this unique tumor from other pediatric central nervous system neoplasms. Cytopathological features, immunohistochemistry and electro-microscopy differential diagnoses are discussed.Los tumores de tipo rabdoide primarios en cualquier sitio son raros y en el sistema nervioso central son extremadamente raros y ocurren principalmente en niños, el tumor teratoide/rabdoide es el tumor más frecuente dentro de este grupo y de evolución clínica fatal. El tumor neuroectodermico primitivo, medulobalstoma y al carcinoma de plexos coroides son tumores generalmente muestran aspectos clínicos radiológicos e histológicos similares, con evolución diferente. Presentamos el caso de un hombre joven de 18 años que inició con cefalea vómitos y ataxia. La imagen de TC muestra tumor en fosa posterior. Se realizó resecci

  13. El Enigma de las Causas de la Diabetes Mellitus Tipo 2 El Enigma de las Causas de la Diabetes Mellitus Tipo 2

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    Juan Manuel Malacara

    2012-02-01

    Full Text Available Type 2 diabetes mellitus the most frequent metabolic disease, is induced by factors so far largely unknown. Genetic and environmental causes are implicated, among the latter obesity and sedentary life are the most important. The discovery of new hormones controlling food intake such as leptin, ghrelin and the YY3-36 peptide, are expected to provide new tools to reduce overfeeding. The genes associated with type 2 diabetes are intensively sought without success.It is possible that the genetic transmission is more complex than suppossed. The theory of the thrifty gene proposes an explanation for the increased obesity and diabetes in ethnic groups in transition from preindustrial to industrialized cultures. The theory of the fetal origins of adult disease, proposes that in the fetal life there is a window for metabolic programming under stress or caloric restriction. If the subject, however, at the adult life consumes excessive caloric intake, has a high risk for the metabolic syndrome. The mechanisms involved in insulin resistance are complex, and several molecules are under study as candidates to explain it. The diminution in insulin secretion is an other important factor for the initiation of type 2 diabetes. Glucotoxicity and lipotoxicity are factors that further reduce insulin secretion. Recent evidence indicates that inflammation is implicated in the onset of both diabetes and atherosclerosis. The elucidation of the nature of this process, as well as the pathways involved will be another important tool for a better management of this disease.La causa de la diabetes mellitus tipo 2, la enfermedad metabólica más frecuente, no es bien conocida. Tiene un componente genético y otro ambiental, en éste destacan la obesidad y el sedentarismo. El conocimiento de las nuevas hormonas que controlan la alimentación: la leptina, la ghrelina y el péptido YY3-36, es una esperanza para el control de la obesidad. No se han identificado los genes

  14. Uso de incrustaciones de resina compuesta tipo onlay en molares estructuralmente comprometidos

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    Alberto Carlos Cruz González

    2012-03-01

    Full Text Available Las incrustaciones en resina compuesta son una alternativa de bajo costo ante los métodos de obturación directos, frente a las dificultades de la adaptación marginal y la ubicación de contactos proximales, porque permiten otorgar una mejor anatomía dental a la restauración y superar el fenómeno de contracción al polimerizar grandes capas de material por fuera de la cavidad dental. El objetivo del presente artículo fue exponer el uso de la resina compuesta bajo técnica indirecta como una alternativa de fácil manipulación y resultados clínicos considerables ante la afectación estructural de molares. Se presentaron dos casos clínicos de incrustaciones con resina compuesta de tipo inlay onlay en dos molares permanentes afectados estructuralmente, uno de ellos fue tratado endodónticamente. Para la obtención de un troquel de trabajo sobre el que se confecciona la incrustación bajo técnica incremental se obtienen modelos al impresionar con alginato la arcada de los dientes seleccionados, se realiza vaciado en silicona liviana del diente preparado y el resto en yeso piedra tipo III. El proceso de cementación en la cavidad bucal se lleva a cabo con cemento resinoso de doble curado. Las incrustaciones fueron sometidas a un control a los seis meses para evaluar los signos de filtración o desadaptación marginal mediante el secado con aire de la jeringa triple, explorador y radiografías periapicales, que mostraron ausencia de desadaptación o pigmentación marginal. Se concluyó que ante la afectación estructural de molares, las incrustaciones con resina compuesta bajo técnica indirecta fueron de fácil manipulación y se obtuvieron satisfactorios resultados clínicos.

  15. Catarata e diabetes mellitus tipo 1 Cataract and type 1 diabetes mellitus

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    Melissa Manfroi Dal Pizzol

    2008-08-01

    Full Text Available OBJETIVO: Avaliar a prevalência de catarata e seus fatores de risco em uma população portadora de diabetes mellitus tipo 1 (DM1. MÉTODOS: Estudo de casos e controles de um banco de dados de 181 pacientes (362 olhos com diagnóstico de diabetes mellitus tipo 1. Os pacientes foram classificados como casos quando apresentavam diagnóstico de catarata. As variáveis estudadas foram a presença ou não de retinopatia diabética, tratamento com panfotocoagulação, presença de hipertensão arterial sistêmica e neuropatia periférica, colesterol total, triglicerídios séricos, HDL, LDL, índice de massa corporal, creatinina sérica, albuminúria, hemoglobina glicosilada e glicemia de jejum. RESULTADOS: A prevalência de catarata foi de 19,9%. Na análise univariada foi encontrada associação estatisticamente significativa (pPURPOSE: To evaluate the prevalence of cataract and associated risk factors in a diabetic type 1 population. METHODS: 181 patients (362 eyes were evaluated in a case-control study. Cases were classified when cataract was present at the time of the examination. The studied outcomes were the presence of diabetic retinopathy, retinal panphotocoagulation, high blood pressure, peripheral neuropathy, total cholesterol levels, triglyceride levels, HDL, LDL, body mass index, creatinine levels, albuminuria, glycosylated hemoglobin and glycemia levels. RESULTS: Cataract was present in 19.9% of the studied patients. The association of the presence of cataract and diabetic retinopathy, peripheral neuropathy, elevated levels of creatinine, panphotocoagulation and high blood pressure were statistically significant (univariate analysis. After the logistic regression analysis the presence of cataract was significantly associated with the presence of diabetic retinopathy. CONCLUSION: The prevalence of cataract was 19.9% and the presence and severity of the diabetic retinopathy were the main risk factors for its development.

  16. Resistência de genótipos de caupi ao caruncho

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    BARRETO PAULO DIÓGENES

    2000-01-01

    Full Text Available A utilização de resistência genética ao ataque de Callosobruchus maculatus (Fabr. tem sido alvo de investigação científica, especialmente no que diz respeito à identificação de fontes de resistência. O presente trabalho objetivou incorporar, ao grupo de caracteres desejáveis para o cultivo de caupi (Vigna unguiculata (L. Walp., resistência genética ao caruncho (C. maculatus. Foram realizadas hibridações dos genótipos IT81D-1045 e IT81D-1064 (portadores de resistência ao inseto com CNCx 252-1E/FB, CNCx 187-22D-1 e BR 1-Poty (capazes de transferir resistência a viroses, tolerância à seca, formação de grãos com padrão comercial, elevado potencial de produção e adaptabilidade a diferentes condições ambientais. Populações segregantes obtidas destes cruzamentos foram conduzidas pelo método SPD (descendência de uma única vagem, e na geração F5 foram realizadas seleções individuais. As linhagens obtidas foram avaliadas em conjunto com materiais de origens diferentes, utilizando-se parâmetros associados à infestação da praga. Foi constatado que os genótipos avaliados apresentaram variabilidade quanto à preferência à postura, número de insetos emergidos e número de sementes danificadas; as linhas EVx 37-15E e EVx 37-2E foram as que sofreram menor dano causado pelo caruncho; as variáveis número de ovos, número de insetos emergidos e número de sementes danificadas mostraram-se positiva e significativamente correlacionadas entre si; o grupo das linhagens que descendem de genitores resistentes apresenta valores significativamente inferiores aos obtidos pelas demais, o que indica que a resistência ao inseto se transmite geneticamente.

  17. Avaliação funcional dos pés de portadoresde diabetes tipo II

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    Vinicius Saura Cardoso

    2013-12-01

    Full Text Available Objetivo: Avaliar a ocorrência de alterações funcionais e o risco de desenvolver úlceras nos pacientes diabéticos tipo II atendidos em Unidades Básicas de Saúde (UBS. Métodos: Realizou-se estudo transversal, quantitativo e descritivo com 80 portadores de diabetes mellitus (DM tipo II que apresentavam idade entre 41 e 85 anos e frequentavam as UBS do município de Parnaíba-PI. Os voluntários responderam ao questionário de identificação e ao Michigan Neuropathy Screening Instrument (MNSI, seguido da avaliação dos membros inferiores, sendo: reflexos aquileu e patelar; palpação dos pulsos arteriais (tibial posterior e pedioso; sensibilidade tátil (monofilamento 10g e vibratória (diapasão 128 Hz; identificação da presença de alterações como unha encravada, calosidades, dedos em garra e queda de pelos. Por fim, utilizando as informações adquiridas na avaliação, os voluntários foram classificados quanto ao risco de desenvolver feridas. Resultados: A amostra foi composta por 76 diabéticos, com média de idade de 63,8±10,4 anos, sendo 63 (82,8% do sexo feminino, com média de tempo de diagnóstico de 8,8±7,2 anos, média do índice de massa corpórea (IMC de 28,2±5,4 Kg/m2, sendo 15,7% da amostra fumantes. Os reflexos miotáticos e pulsos arteriais apresentaram-se hiporreflexos e diminuídos, respectivamente. A sensibilidade tátil foi identificada em 81,5%, e 13,1% não sentiram a vibração do diapasão. A calosidade foi a alteração mais prevalente em 76,3% (n=58. O risco 2 de desenvolver úlceras se sobressaiu, 52,6% (n=40. Conclusão: Observaram-se alterações funcionais na amostra estudada e uma classificação de risco 2 para desenvolvimento de feridas em mais de 50% dos avaliados.

  18. Estilo de vida en pacientes adultos con Diabetes mellitus tipo 2

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    Pedro César Cantú-Martínez

    2014-10-01

    Full Text Available Antecedentes: se examina y describe el estilo de vida de pacientes con Diabetes mellitus tipo 2, los cuales asistieron al control de diabetes en diferentes Centros de Salud Urbanos del Área Metropolitana de Monterrey, N.L., México, para estudiar los determinantes individuales y establecer la relación entre el estilo de vida evaluado y el percibido.Método: la muestra fue no aleatoria, seleccionada por conveniencia, en el orden de asistencia a consulta. La población fue de 65 pacientes, que contaron con características muy similares, de acuerdo con el diagnóstico de diabetes mellitus tipo 2 y que accedieron voluntariamente a participar, en el periodo julio-septiembre del año 2012. Se utilizó el instrumento denominado IMEVID, para explorar el estilo de vida y se relacionó con la percepción de los pacientes y sus dimensiones.Resultado: se colige que un 29,23% consideraba tener un “buen estilo de vida”, porcentaje que correspondió a una clasificación “saludable”, mientras que la mayor concentración se tiene un inadecuado estilo de vida (70,77%, con dos clasificaciones de los participantes; luego, un 56,92% se caracteriza por una conducta “moderadamente saludable” y solamente el 13,85% de estos se catalogó como “poco saludable”. Se detectó una correlación significativa entre el estilo de vida evaluado y las dimensiones consideradas, excepto con el estado emocional. Asimismo, se estableció una relación entre el estilo de vida evaluado y el percibido por los participantes.Conclusión: el paulatino esclarecimiento del concepto denominado “estilo de vida” ha permitido redimensionar la noción del estado de “salud-enfermedad”. Los resultados concuerdan con otras investigaciones desarrolladas en México.

  19. Tipos de hogar, ciclo de vida familiar y pobreza en Costa Rica 1987-2002

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    Jorge A. Barquero B.

    2004-01-01

    Full Text Available El propósito de este estudio fue el de explorar las condiciones de vulnerabilidad sociodemográfica en Costa Rica, a partir del análisis de los cambios en los tipos de hogar y el ciclo de vida de las familias en condiciones de pobreza, mediante la utilización de información de las encuestas de hogares de 1987, 1994 y 2002. Los principales hallazgos revelan modificaciones importantes en la estructura y composición de los hogares y familias en el periodo de estudio, asociado a cambios en la dinámica sociodemográfica de la sociedad costarricense. La evolución en la incidencia de la pobreza por tipo de hogar, muestra que ésta es mayor entre los hogares nucleares que cuentan con hijos y al convertirse en monoparentales. La incidencia es más alta en 1987, se reduce para 1994 y prácticamente se mantiene para el 2002. No obstante que en todas las fases del ciclo de vida familiar la incidencia de la pobreza disminuyó en el periodo 1987-1994, en el periodo más reciente al 2002 la incidencia es mayor en las etapas en que las familias poseen más hijos dependientes menores de 18 años, lo que expone a estas familias a una mayor vulnerabilidad a situaciones de pobreza. Los hogares y familias con mayor riesgo de vulnerabilidad ante la pobreza, se hallaron entre aquellos con mayor cantidad de miembros dependientes menores de edad y jefeados por mujeres. No se encontraron evidencias significativas para afirmar que el estancamiento observado en los niveles de pobreza en el país hasta el 2002, fuese producto de los cambios encontrados en los patrones familiares, aunque ciertamente se hace necesario profundizar el análisis de las interrelaciones entre pobreza y cambios demográficos.

  20. Desempenho de genótipos de aveia branca em resposta ao estresse por alumínio

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    Solange Ferreira da Silveira Silveira

    2013-01-01

    Full Text Available A aveia branca (Avena sativa L. é uma cultura que tem um papel importante no sistema de produção de grãos e integração lavoura-pecuária, no entanto, em algumas regiões brasileiras, o pleno estabelecimento e desenvolvimento dessa cultura, bem como o aumento de produtividade são inviabilizados pelo excesso de alumínio (Al nos solos. A avaliação de caracteres de plântulas de aveia desenvolvidas sob cultivo hidropônico com adoção de solução nutritiva mínima pode ser eficiente para classificar genótipos sensíveis e tolerantes ao Al. Este trabalho objetivou avaliar o desempenho de 10 genótipos de aveia submetidos ao estresse por Al, baseando-se na análise da retomada do crescimento da raiz, com uso de solução mínima e identificando quais caracteres se mantêm correlacionados. Foram adotadas diferentes doses de Al (0, 3, 6, e 9 mg L-1 de Al. Com uso de solução mínima, a dose de 6 mg L-1 de Al é a mais adequada na diferenciação de genótipos sensíveis e tolerantes. Dentre os genótipos estudados, UFRGS 14, UFRGS 19 e URS Guapa são os mais tolerantes e UPFA 20, UPF 18 e IAC 7, os mais sensíveis ao Al. Com o objetivo de classificar genótipos de aveia entre sensíveis e tolerantes ao Al, nenhuma outra variável pode ser utilizada em substituição à retomada do crescimento da raiz.