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Sample records for timothy roy gleason

  1. Debjani Roy

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Debjani Roy. Articles written in Resonance – Journal of Science Education. Volume 1 Issue 9 September 1996 pp 86-88 Book Review. Take the Frogs Seriously - They are the Earth's Living Barometers A Book for One and All · Debjani Roy · More Details Fulltext ...

  2. Rahul Roy

    Indian Academy of Sciences (India)

    Rahul Roy. Articles written in Resonance – Journal of Science Education. Volume 2 Issue 11 November 1997 pp 36-47 General Article. Ohm's Law, Kirchoff's Law and the Drunkard's Walk Related Electrical Networks · Rahul Roy · More Details Fulltext PDF. Volume 2 Issue 12 December 1997 pp 33-38 General Article.

  3. Tapas Kumar Roy

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Tapas Kumar Roy. Articles written in Journal of Biosciences. Volume 40 Issue 2 June 2015 pp 375-387 Articles. Do seed VLCFAs trigger spongy tissue formation in Alphonso mango by inducing germination? Seshadri Shivashankar Manoharan Sumathi Tapas Kumar Roy.

  4. Omaenese edevuse ohver Timothy Treadwell / Mati Kaal

    Index Scriptorium Estoniae

    Kaal, Mati, 1946-

    2007-01-01

    Dokumentaalfilm "Grislimees" ("Grizzly Man") Timothy Treadwellist, kes elas 13 aastat Alaskal koos grislidega, režissöör Werner Herzog (Ameerika Ühendriigid, 2005). Tallinna Loomaaia direktor arutleb inimliku edevuse teemal, mis metsikus looduses viis režissööri traagilise hukuni

  5. Professing English a life of Roy Daniells

    CERN Document Server

    Djwa, Sandra

    2002-01-01

    Roy Daniells (1902-1979), an English professor who finished his career at the University of British Columbia, and an outstanding scholar, teacher and poet, influenced at least four generations of students.

  6. Gleason-Busch theorem for sequential measurements

    Science.gov (United States)

    Flatt, Kieran; Barnett, Stephen M.; Croke, Sarah

    2017-12-01

    Gleason's theorem is a statement that, given some reasonable assumptions, the Born rule used to calculate probabilities in quantum mechanics is essentially unique [A. M. Gleason, Indiana Univ. Math. J. 6, 885 (1957), 10.1512/iumj.1957.6.56050]. We show that Gleason's theorem contains within it also the structure of sequential measurements, and along with this the state update rule. We give a small set of axioms, which are physically motivated and analogous to those in Busch's proof of Gleason's theorem [P. Busch, Phys. Rev. Lett. 91, 120403 (2003), 10.1103/PhysRevLett.91.120403], from which the familiar Kraus operator form follows. An axiomatic approach has practical relevance as well as fundamental interest, in making clear those assumptions which underlie the security of quantum communication protocols. Interestingly, the two-time formalism is seen to arise naturally in this approach.

  7. Prognostic implications of 2005 Gleason grade modification

    DEFF Research Database (Denmark)

    Thomsen, Frederik Birkebæk; Folkvaljon, Yasin; Brasso, Klaus

    2016-01-01

    ,890 men assessed with the modified Gleason classification, diagnosed between 2003 and 2007, underwent primary RP. Histopathology was reported according to the Gleason Grading Groups (GGG): GGG1 = Gleason score (GS) 6, GGG2 = GS 7(3 + 4), GGG3 = GS 7(4 + 3), GGG4 = GS 8 and GGG5 = GS 9-10. Cumulative...... incidence and multivariable Cox proportional hazards regression models were used to assess difference in BCR. RESULTS: The cumulative incidence of BCR was lower using the modified compared to the original classification: GGG2 (16% vs. 23%), GGG3 (21% vs. 35%) and GGG4 (18% vs. 34%), respectively. Risk......OBJECTIVE: To assess the impact of the 2005 modification of the Gleason classification on risk of biochemical recurrence (BCR) after radical prostatectomy (RP). PATIENTS AND METHODS: In the Prostate Cancer data Base Sweden (PCBaSe), 2,574 men assessed with the original Gleason classification and 1...

  8. Oncologic Outcomes of Patients With Gleason Score 7 and Tertiary Gleason Pattern 5 After Radical Prostatectomy

    OpenAIRE

    Leng, Yi-Hsueh; Lee, Won Jun; Yang, Seung Ok; Lee, Jeong Ki; Jung, Tae Young; Kim, Yun Beom

    2013-01-01

    Purpose We evaluated oncologic outcomes following radical prostatectomy (RP) in patients with a Gleason score (GS) of 7 with tertiary Gleason pattern 5 (TGP5). Materials and Methods We retrospectively reviewed the medical records of 310 patients who underwent RP from 2005 to 2010. Twenty-four patients who received neoadjuvant or adjuvant antiandrogen deprivation or radiation therapy were excluded. Just 239 (GS 6 to 8) of the remaining 286 patients were included in the study. Patients were cla...

  9. Primary Gleason pattern in biopsy Gleason score 7 is predictive of adverse histopathological features and biochemical failure following radical prostatectomy

    DEFF Research Database (Denmark)

    Berg, Kasper Drimer; Røder, Martin Andreas; Brasso, Klaus

    2014-01-01

    +3. No difference in age, PSA, percentage of biopsies with cancer, clinical tumour stage or volume on transrectal ultrasonography was found. Primary Gleason pattern 4 was associated with worse pathological stage (p = 0.049). On multivariate analysis, primary Gleason pattern 4 (p ... (p analysis, Gleason score 3+4 had a significantly lower biochemical failure rate compared with Gleason score 4+3 (p = 0.0035). PSA (p 4 (p = 0.001) and percentage of biopsies...

  10. The Roy Adaptation Model and Content Analysis

    OpenAIRE

    Fawcett, Jacqueline

    2006-01-01

    The purpose of this paper is to explain how the Roy Adaptation Model can be used to guide a combined qualitative and quantitative content analysis of responses to open-ended interviews questions. Responses can be categorized as adaptive or ineffective within the physiological, self-concept, role function, and interdependence modes of adaptation and then tallied to yield an adaptation score. El objetivo del presente estudio consiste en explicar de qué manera se puede utilizar el Modelo de A...

  11. The Genetics Underlying Vernalization in Timothy (Phleum pratense L.)

    DEFF Research Database (Denmark)

    Fiil, Alice

    Vernalization is the process where the transition from the vegetative to the reproductive state is promoted by a prolonged period of cold. Timothy (Phleum pratense L.) is an important forage grass in the Nordic countries. Unlike many other temperate grasses, a vernalization requirement has not been...... reported in this species. The objectives of this Ph.D. study were to obtain a better understanding of vernalization in timothy and knowledge about the genetics underlying the vernalization response. The vernalization response was analyzed in 38 genotypes of diverse geographic origin. Vernalization...... that significant genetic variation for the vernalization response is present within timothy and suggest that differential regulation of VRN1 transcription discriminates genotypes with contrasting vernalization responses. In addition, the nucleotide diversity and linkage disequilibrium were analyzed in nine genes...

  12. An Interview with Professor Roy Caldwell

    OpenAIRE

    Chowdhary, Kuntal; Bhat, Prashant; Rosen, Jared; Naughton, Ida; Wang, Jingyan

    2013-01-01

    Envision the underwater world: vibrant coral, swaying seaweed, and lively creatures abound. However, the postcards and National Geographic covers that try to capture the beauty of this picturesque habitat can only represent it at one moment in time -- in reality, the landscape is hardly static, since many of its animals are capable of body modifications to change their shape and color. To understand the coloration and color vision of sea creatures, UC Berkeley Professor Roy L. Caldwell resear...

  13. The Roy Adaptation Model and Content Analysis

    OpenAIRE

    Jacqueline Fawcett

    2006-01-01

    El objetivo del presente estudio consiste en explicar de qué manera se puede utilizar el Modelo de Adaptación de Roy para guiar el análisis de contenido cuantitativo y cualitativo de respuestas a preguntas abiertas en una entrevista. Estas respuestas pueden ser catalogadas como adaptativas o inefectivas respecto de los modos de adaptación psicosocial, autoconcepto, función de rol e interdependencia y, entonces, asociadas a un determinado puntaje de adaptación.

  14. Posthumous Pardons, the Home Office and the Timothy Evans Case

    OpenAIRE

    Rubin, Gerry

    2007-01-01

    Examines the legal issues surrounding the exercise of the prerogative of mercy to grant posthumous pardons either to those convicted of a capital offence or those executed for offences under military law, specifically during the First World War. Focuses on the policy considerations leading to the Home Secretary’s decision to recommend the grant of a posthumous pardon for Timothy Evans in 1966.

  15. Obituary: Timothy Hawarden (1943-2009)

    Science.gov (United States)

    Robson, Ian

    2011-12-01

    British astronomy lost one of its most respected and liked members with the sudden death of Dr Timothy (Tim) Hawarden. Hawarden was one of those people who changed his wavelength and discipline as the emerging challenges of astronomy dictated, and was successful in all of his ventures. He experienced a huge breadth of achievement; moving from photographic plates, through electronic detectors to infrared astronomy from the ground and subsequently from space. He was an acknowledged leader in his fields around the world and, in addition to his professional accomplishments, he was a keen practitioner of culinary technique. His bouillabaisse was legendary. In his later years he was a source of inspiration for young children in his outreach work. Tim Hawarden began his career as an optical astronomer in South Africa. He graduated from the University of Natal, Pietermaritzburg in 1966 with a BSc in Physics and Applied Mathematics, followed by an MSc in Astronomy from the University of Cape Town in 1970 and a PhD in 1975. Hawarden's early years were formed by learning the precise art of photometry from the legendary Cousins, and this focus on precision has stood him in good stead throughout his career. He then moved Australia in 1975, where he spent three years as Deputy Astronomer-in-Charge of the UK Schmidt Telescope, from where he moved to the Royal Observatory Edinburgh, where he remained for the rest of his career. Hawarden rapidly moved into the newly emerging field of infrared astronomy. His research moved from stars and stellar clusters to barred spiral galaxies and he was keen to employ the new tools coming on-line to pursue this work. The United Kingdom Infrared Telescope (KIRT) was the world's premier facility and Tim Hawarden became the Head of the unit at the ROE in 1981, a post he held for the next six years, overseeing a range of developments that have stood the test of time and have provided the platform on which UKIRT has retained its world-class standing

  16. Does true Gleason pattern 3 merit its cancer descriptor?

    Science.gov (United States)

    Miah, Saiful; Ahmed, Hashim U; Freeman, Alex; Emberton, Mark

    2016-09-01

    Nearly five decades following its conception, the Gleason grading system remains a cornerstone in the prognostication and management of patients with prostate cancer. In the past few years, a debate has been growing whether Gleason score 3 + 3 = 6 prostate cancer is a clinically significant disease. Clinical, molecular and genetic research is addressing the question whether well characterized Gleason score 3 + 3 = 6 disease has the ability to affect the morbidity and quality of life of an individual in whom it is diagnosed. The consequences of treatment of Gleason score 3 + 3 = 6 disease are considerable; few men get through their treatments without sustaining some harm. Further modification of the classification of prostate cancer and dropping the label cancer for Gleason score 3 + 3 = 6 disease might be warranted.

  17. The effect of additives in silages of pure timothy and timothy mixed with red clover on chemical composition and in vitro rumen fermentation characteristics

    NARCIS (Netherlands)

    Hetta, M.; Cone, J.W.; Gustavsson, A.M.; Martinsson, K.

    2003-01-01

    The aim was to compare the effects of additives on direct cut silages of pure timothy and timothy mixed with tetraploid red clover. First and second growth cuts were ensiled during three consecutive years, 1994, 1995 and 1996, either without any additive or with the addition of formic acid, or

  18. Gleason Score Correlation Between Prostate Biopsy and Radical Prostatectomy Specimens

    Directory of Open Access Journals (Sweden)

    Erdem Öztürk

    2018-04-01

    Full Text Available Objective: Prostate cancer is the most common malignancy in men and the second cause of cancer-related mortality. Prostate biopsy and the Gleason score guide treatment decisions in prostate cancer. Several studies have investigated the correlation between biopsy scores and radical prostatectomy specimen scores. We also evaluated the correlation of Gleason scores of these specimens in our patient series. Materials and Methods: We retrospectively reviewed the data of 468 men who were diagnosed with prostate cancer and underwent radical prostatectomy between 2008 and 2017. Patients’ age, prostate-specific antigen levels at diagnosis, and prostate biopsy and radical prostatectomy specimen Gleason scores were recorded. Upgrading and downgrading were defined as increase or decrease of Gleason score of radical prostate specimen compared to Gleason score of prostate biopsy. Results: A total of 442 men diagnosed with prostate cancer were included in the study. The mean age of the patients was 62.62±6.26 years (44-84 years and mean prostate specific antigen level was 9.01±6.84 ng/mL (1.09-49 ng/mL. Prostate biopsy Gleason score was 7 in 27 (6.1% men. Radical prostatectomy specimen Gleason score was 7 in 62 (14% men. Gleason correlation was highest in the 240 patients (71.6% with score <7 and was lowest in the 31 (38.75% patients with score =7. Conclusion: This study demonstrated that the discordance rate between Gleason scores of prostate biopsy and radical prostatectomy specimens was 35.7%.

  19. Response of mouse splenic lymphocytes to timothy pollen antigens in a microculture system.

    Science.gov (United States)

    Fairchild, S S; Malley, A

    1975-12-01

    Spleen cells from LAF1 mice were stimulated in a microculture system with T and B cell mitogens or antigens of timothy pollen. Only cells from mice immunized with crude timothy pollen extract (WST) or a major antigen of timothy pollen conjugated to Ascaris (antigen B-Ascaris) responded to timothy antigens in vitro. Optimum responses were obtained at 120 to 144 hr of culture with 5 to 10 mug WST per culture and ranged from three to 10 times greater than cell background. No correlations could be found between the optimum antigen concentration or the maximum response and the immune status of the spleen cell donor. Response could be inhibited by a dialyzable fraction of timothy pollen, antigen D, which is a monovalent form of a major antigen of timothy pollen.

  20. Timothy-specific IgG antibody levels vary with the pollen seasons.

    Science.gov (United States)

    Nordvall, S L; Larsson, P H; Johansson, S G

    1986-11-01

    Serum samples were collected from eight grass pollen hypersensitive children during a 4-year period. The sera were assayed for contents of timothy-specific IgE antibodies by RAST. Timothy-specific IgG and IgA antibodies were quantified by a refined ELISA in which covalent binding of the antigen to the polystyrene solid phase had been performed. IgG antibodies were also assayed by a Sepharose-protein-A technique with radiolabelled timothy allergens as the antigen. It was possible to register clearcut seasonal variations with postseasonally boosted antibody levels not only of timothy-specific IgE but also of IgG antibody. Both IgG1 and IgG4 antibodies specific for timothy showed seasonal variations of a similar degree. It was not possible to register seasonal variations of the same magnitude of timothy-specific IgA antibodies.

  1. Variation in the vernalization response of a geographically diverse collection of timothy genotypes

    DEFF Research Database (Denmark)

    Fiil, Alice; Jensen, Louise Bach; Fjellheim, Siri

    2011-01-01

    Timothy (Phleum pratense L.) has earlier been characterized as a long-day plant, which neither requires vernalization to induce flowering nor shows a vernalization response. Variation in flowering time of timothy has thus been ascribed to differences in critical photoperiods. We studied vernaliza......Timothy (Phleum pratense L.) has earlier been characterized as a long-day plant, which neither requires vernalization to induce flowering nor shows a vernalization response. Variation in flowering time of timothy has thus been ascribed to differences in critical photoperiods. We studied...

  2. Obituary: Roy Henry Garstang (1925-2009)

    Science.gov (United States)

    Malville, J.

    2011-12-01

    Roy Henry Garstang 84 passed away on November 1, 2009 in Boulder Colorado. He was born in Southport, England in September of 1925 to Percy Brocklehurst and Eunice (Gledhill) Garstang. He won a scholarship to Caius College in Cambridge University. Because it was wartime, he could spend only two years at his studies. However, he managed to complete three years of required work during that time, and then spent 1945-46 as a Junior Scientific Officer at the Royal Aircraft Establishment at Farnborough. He received his BA in 1946 from Cambridge, his MA in 1950, and his PhD in Mathematics in 1954, with a thesis: "Atomic Transitions in Astrophysics," working under D. R. Hartree. He also received a ScD from Cambridge in Physics and Chemistry in 1983. He married Ann in August 1959. She and two daughters, Jennifer and Susan, survive him. While still pursuing his PhD, Roy Garstang served as a Research Associate at the Yerkes Observatory, from 1951-1952, working under Subrahmanyan Chandrasekhar. During that time he continued with his own calculations of atomic structure and transition probabilities, although these were not part of Chandra's research interests. After earning his PhD, he went to teach at the University of London, where he also served as the Assistant Director of the University of London Observatory (1959-1964). He was editor of "The Observatory" Magazine form 1953-1960. The continuing theme of this research was to help meet the needs of astrophysicists for atomic data. In 1964, he left England for the United States, where he joined the faculty at the University of Colorado, Boulder, where he would remain for the rest of his professional career. It was entirely fitting, considering his interest in performing calculations of interest to astrophysicists, that soon after arriving in Boulder he was appointed Chairman of JILA - Joint Institute for Laboratory Astrophysics (1966-1967). He was Director of the Division of Physics and AstroGeophysics (1979-80), acting

  3. Impact of Primary Gleason Grade on Risk Stratification for Gleason Score 7 Prostate Cancers

    International Nuclear Information System (INIS)

    Koontz, Bridget F.; Tsivian, Matvey; Mouraviev, Vladimir; Sun, Leon; Vujaskovic, Zeljko; Moul, Judd; Lee, W. Robert

    2012-01-01

    Purpose: To evaluate the primary Gleason grade (GG) in Gleason score (GS) 7 prostate cancers for risk of non-organ-confined disease with the goal of optimizing radiotherapy treatment option counseling. Methods: One thousand three hundred thirty-three patients with pathologic GS7 were identified in the Duke Prostate Center research database. Clinical factors including age, race, clinical stage, prostate-specific antigen at diagnosis, and pathologic stage were obtained. Data were stratified by prostate-specific antigen and clinical stage at diagnosis into adapted D’Amico risk groups. Univariate and multivariate analyses were performed evaluating for association of primary GG with pathologic outcome. Results: Nine hundred seventy-nine patients had primary GG3 and 354 had GG4. On univariate analyses, GG4 was associated with an increased risk of non-organ-confined disease. On multivariate analysis, GG4 was independently associated with seminal vesicle invasion (SVI) but not extracapsular extension. Patients with otherwise low-risk disease and primary GG3 had a very low risk of SVI (4%). Conclusions: Primary GG4 in GS7 cancers is associated with increased risk of SVI compared with primary GG3. Otherwise low-risk patients with GS 3+4 have a very low risk of SVI and may be candidates for prostate-only radiotherapy modalities.

  4. Impact of Primary Gleason Grade on Risk Stratification for Gleason Score 7 Prostate Cancers

    Energy Technology Data Exchange (ETDEWEB)

    Koontz, Bridget F., E-mail: bridget.koontz@duke.edu [Department of Radiation Oncology, Duke Prostate Center, Duke University Medical Center, Durham, NC (United States); Tsivian, Matvey [Division of Urology, Department of Surgery, Duke Prostate Center, Duke University Medical Center, Durham, NC (United States); Mouraviev, Vladimir [Department of Radiation Oncology, Duke Prostate Center, Duke University Medical Center, Durham, NC (United States); Sun, Leon [Division of Urology, Department of Surgery, Duke Prostate Center, Duke University Medical Center, Durham, NC (United States); Vujaskovic, Zeljko [Department of Radiation Oncology, Duke Prostate Center, Duke University Medical Center, Durham, NC (United States); Moul, Judd [Division of Urology, Department of Surgery, Duke Prostate Center, Duke University Medical Center, Durham, NC (United States); Lee, W. Robert [Department of Radiation Oncology, Duke Prostate Center, Duke University Medical Center, Durham, NC (United States)

    2012-01-01

    Purpose: To evaluate the primary Gleason grade (GG) in Gleason score (GS) 7 prostate cancers for risk of non-organ-confined disease with the goal of optimizing radiotherapy treatment option counseling. Methods: One thousand three hundred thirty-three patients with pathologic GS7 were identified in the Duke Prostate Center research database. Clinical factors including age, race, clinical stage, prostate-specific antigen at diagnosis, and pathologic stage were obtained. Data were stratified by prostate-specific antigen and clinical stage at diagnosis into adapted D'Amico risk groups. Univariate and multivariate analyses were performed evaluating for association of primary GG with pathologic outcome. Results: Nine hundred seventy-nine patients had primary GG3 and 354 had GG4. On univariate analyses, GG4 was associated with an increased risk of non-organ-confined disease. On multivariate analysis, GG4 was independently associated with seminal vesicle invasion (SVI) but not extracapsular extension. Patients with otherwise low-risk disease and primary GG3 had a very low risk of SVI (4%). Conclusions: Primary GG4 in GS7 cancers is associated with increased risk of SVI compared with primary GG3. Otherwise low-risk patients with GS 3+4 have a very low risk of SVI and may be candidates for prostate-only radiotherapy modalities.

  5. Roy Walford and the immunologic theory of aging

    Directory of Open Access Journals (Sweden)

    Effros Rita B

    2005-04-01

    Full Text Available Abstract Roy Walford died on April 27, 2004, at the age of 79. His contributions to gerontological research in such diverse areas as caloric restriction, genetics of lifespan, immunosenescence, DNA repair and replicative senescence were truly remarkable in their depth and innovation. Significantly, most of the areas that he pioneered during his illustrious research career remain the "hot" areas of current gerontological research. In this sense, he has achieved the most important type of immortality. His death was a major personal and professional loss to numerous scientists within the gerontological community. In launching this new journal on Immunity and Ageing, it is highly fitting, therefore, to remember him on the anniversary of his death by briefly reviewing the contributions of Roy Walford to this important facet of gerontology. Indeed, it was Roy who actually first coined the commonly used term "immunosenescence".

  6. Lessons from Queer Bioethics: A Response to Timothy F. Murphy.

    Science.gov (United States)

    Richie, Cristina

    2016-06-01

    'Bioethics still has important work to do in helping to secure status equality for LGBT people' writes Timothy F. Murphy in a recent Bioethics editorial. The focus of his piece, however, is much narrower than human rights, medical care for LGBT people, or ending the HIV/AIDS pandemic. Rather, he is primarily concerned with sexuality and gender identity, and the medical intersections thereof (i.e. DSM diagnosis; access to SrS or ARTs). It is the objective of this response to provide an alternate account of bioethics from a Queer perspective. I will situate Queer bioethics within Queer studies, and offer three 'lessons' that bioethics can derive from this perspective. These are not definitive rules for Queer bioethics, since it is a field which fundamentally opposes categorizations, favoring pastiche over principles. These lessons are exploratory examples, which both complement and contradict LGBT bioethics. My latter two lessons - on environmental bioethics and disability - overlap with some of Murphy's concerns, as well as other conceptions of LGBT bioethics. However, the first lesson takes an antithetical stance to Murphy's primary focus by resisting all forms of heteroconformity and disavowing reproduction as consonant with Queer objectives and theory. The first lesson, which doubles as a primer in Queer theory, does heavy philosophical lifting for the remainder of the essay. This response to Timothy F. Murphy, whose work is certainly a legacy in bioethics, reveals the multiplicity of discourses in LGBT/Queer studies, many of which are advantageous - even essential - to other disciplines like bioethics. © 2016 John Wiley & Sons Ltd.

  7. Apparent diffusion coefficient ratio correlates significantly with prostate cancer gleason score at final pathology

    DEFF Research Database (Denmark)

    Boesen, Lars; Chabanova, Elizaveta; Løgager, Vibeke

    2015-01-01

    PURPOSE: To evaluate the correlation between apparent diffusion coefficient measurements (ADCtumor and ADCratio ) and the Gleason score from radical prostatectomy specimens. MATERIALS AND METHODS: Seventy-one patients with clinically localized prostate cancer scheduled for radical prostatectomy...... correlated with the Gleason score from the prostatectomy specimens. RESULTS: The association between ADC measurements and Gleason score showed a significant negative correlation (P ... ) and 0.90 (ADCratio ) when discriminating Gleason score ≤7(3+4) from Gleason score ≥7(4+3). CONCLUSION: ADC measurements showed a significant correlation with tumor Gleason score at final pathology. The ADCratio demonstrated the best correlation compared to the ADCtumor value and radically improved...

  8. Resisting the author: JT LeRoy's fictional authorship

    NARCIS (Netherlands)

    Loontjens, J.

    2008-01-01

    In the last decade, the interest in the relation between author and text, author and autobiography, seems to have grown. In my article, I use the story of the author JT LeRoy as a framework to analyse what this growing interest means for our understanding of the word "author." JT LeRoy’s work was

  9. Mel Ramos ja Roy Lichtenstein Albertinas / Jaan Elken

    Index Scriptorium Estoniae

    Elken, Jaan, 1954-

    2011-01-01

    Mel Ramose retrospektiivnäitus "Mel Ramos : 50 Years of Pop Art" 29. maini 2011 ja Roy Lichtensreini mustvalgete tööde valik "Black & White 1961-1968" 15. maini 2011 Viini Albertinas. Lühidalt näitusest "Power Up - Female Pop Art" Viini Kunstihalles

  10. Association of Gleason Risk Groups with Metastatic Sites in Prostate ...

    African Journals Online (AJOL)

    Prostate cancer is the second most common non cutaneous male malignancy worldwide. Gleason composite score is used for risk classification. The most common site of metastasis in prostate cancer is the bone among others. The site and number of metastasis affect overall survival. The ability to predict the metastatic site ...

  11. Timothy Coombs: kriise tekib maailmas üha enam / intervjueerinud Kristel Abel

    Index Scriptorium Estoniae

    Coombs, Timothy

    2013-01-01

    Intervjuu riski- ja kriisikommunikatsiooni tippspetsialisti dr W. Timothy Coombsiga, kes räägib kriisikommunikatsiooni hetkeseisust ning jagab nõu, kuidas kriisikommunikatsiooniga toime tulla. Ta on välja arendanud situatsiooni kriisikommunikatsiooni teooria

  12. Roy-Steiner equations for πN scattering

    Science.gov (United States)

    de Elvira, J. Ruiz; Ditsche, C.; Hoferichter, M.; Kubis, B.; Meißner, U.-G.

    2015-10-01

    In this talk, we briefly review our ongoing collaboration to precisely determine the low-energy πN scattering amplitude by means of Roy-Steiner equations. After giving a brief overview of this system of dispersive equations and their application to πN scattering, we proceed to solve for the lower partial waves of the s-channel (πN → πN) and the t-channel l( {π π to bar NN} right) sub-problems.

  13. Method and metaphysics in Clements's and Gleason's ecological explanations.

    Science.gov (United States)

    Eliot, Christopher

    2007-03-01

    To generate explanatory theory, ecologists must wrestle with how to represent the extremely many, diverse causes behind phenomena in their domain. Early twentieth-century plant ecologists Frederic E. Clements and Henry A. Gleason provide a textbook example of different approaches to explaining vegetation, with Clements allegedly committed, despite abundant exceptions, to a law of vegetation, and Gleason denying the law in favor of less organized phenomena. However, examining Clements's approach to explanation reveals him not to be expressing a law, and instead to be developing an explanatory structure without laws, capable of progressively integrating causal complexity. Moreover, Clements and Gleason largely agree on the causes of vegetation; but, since causal understanding here underdetermines representation, they differ on how to integrate recognized causes into general theory--that is, in their methodologies. Observers of the case may have mistakenly assumed that scientific representation across the disciplines typically aims at laws like Newton's, and that representations always reveal scientists' metaphysical commitments. Ironically, in the present case, this assumption seems to have been made even by observers who regard Clements as nai ve for his alleged commitment to an ecological law.

  14. Fractal Behavior Of Gleason And Srigley Grading Systems

    Directory of Open Access Journals (Sweden)

    M.S. Serbanescu

    2016-06-01

    In-class variation was 0.045 using the box-counting algorithm and 0.048 using the R-VA algorithm for Gleason grading system and 0.161 using the box-counting algorithm and 0.178 using the R-VA algorithm for Srigley grading system. Inter-class variation was, for Gleason grading system 13/28 using the box-counting algorithm and 20/28 using the R-VA algorithm while for the Srigley grading system was 3/6 using the box-counting algorithm and 5/6 using the R-VA algorithm respectively. Srigley grading system seems to perform better than Gleason’s on inter-class variation, but has lower performance on in-class variation. Nevertheless, we must note that there is a large difference between the two systems regarding the number of classes. The FD computed with the R-VA algorithm has better discrimination results than the one computed with the box-counting algorithm in both grading systems, thus proving once again the R-VA’s performance [3].

  15. IgE-binding capacity of recombinant timothy grass (Phleum pratense) pollen allergens

    NARCIS (Netherlands)

    Laffer, S.; Vrtala, S.; Duchêne, M.; van Ree, R.; Kraft, D.; Scheiner, O.; Valenta, R.

    1994-01-01

    A panel of 60 cDNA clones coding for IgE-binding proteins from timothy grass pollen was immunocharacterized with sera from 30 patients allergic to grass pollen and antibodies raised against natural grass pollen allergens. In the cases of five representative patients in whom the IgE reactivity

  16. Most Gleason 8 Biopsies are Downgraded at Prostatectomy-Does 4 + 4 = 7?

    Science.gov (United States)

    Gansler, Ted; Fedewa, Stacey; Qi, Robert; Lin, Chun Chieh; Jemal, Ahmedin; Moul, Judd W

    2017-10-12

    Nonrepresentative biopsy sampling of prostate cancers with a biopsy Gleason score of 8 can adversely influence decisions regarding androgen deprivation in men receiving primary radiation therapy. The frequency of and factors associated with downgrading Gleason 8 biopsies at prostatectomy are not well known. We used records from NCDB (National Cancer Database), a hospital based registry in the United States, of 72,556 men with prostate cancer diagnosed from 2010 to 2013, including 5,474 with Gleason 8 biopsies and no other high progression risk criteria according to NCCN (National Comprehensive Cancer Network®) Guidelines®. The prevalence of Gleason 8 downgrading was calculated. Generalized estimating equation multivariable regression models were used to estimate the prevalence ratios and 95% CIs of downgrading by demographic and clinical factors, and evaluate the association of Gleason 8 downgrading with cT (clinical T) to pathological T category up staging. Of 5,474 Gleason 8 biopsies in men lacking other high progression risk criteria 3,263 (60%) were downgraded, changing the progression risk category from high to intermediate. A higher prevalence of Gleason 8 downgrading was significantly and independently associated with decreasing age, African American race, lower cT category, lower prostate specific antigen quartile and certain combinations of primary and secondary Gleason grades (3 + 5 greater than 4 + 4 greater than 5 + 3). Gleason 8 downgrading in cases of cT less than 3 was independently and significantly associated with a lower prevalence of up staging (prevalence ratio = 0.65, 95% CI 0.61-0.69). Downgrading Gleason 8 biopsies is common. Patient evaluation based on Gleason 8 biopsies often results in overestimating progression risk and disease extent, which may lead to overtreatment. Copyright © 2018 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  17. Mapping swamp timothy (Cripsis schenoides) seed productivity using spectral values and vegetation indices in managed wetlands

    Energy Technology Data Exchange (ETDEWEB)

    Rahilly, P.J.A.; Li, D.; Guo, Q.; Zhu, J.; Ortega, R.; Quinn, N.W.T.; Harmon, T.C.

    2010-01-15

    This work examines the potential to predict the seed productivity of a key wetland plant species using spectral reflectance values and spectral vegetation indices. Specifically, the seed productivity of swamp timothy (Cripsis schenoides) was investigated in two wetland ponds, managed for waterfowl habitat, in California's San Joaquin Valley. Spectral reflectance values were obtained and associated spectral vegetation indices (SVI) calculated from two sets of high resolution aerial images (May 11, 2006 and June 9, 2006) and were compared to the collected vegetation data. Vegetation data were collected and analyzed from 156 plots for total aboveground biomass, total aboveground swamp timothy biomass, and total swamp timothy seed biomass. The SVI investigated included the Simple Ratio (SR), Normalized Difference Vegetation Index (NDVI), Soil Adjusted Vegetation Index (SAVI), Transformed Soil Adjusted Vegetation Index (TSAVI), Modified Soil Adjusted Vegetation Index (MSAVI), and Global Environment Monitoring Index (GEMI). We evaluated the correlation of the various SVI with in situ vegetation measurements for linear, quadratic, exponential and power functions. In all cases, the June image provided better predictive capacity relative to May, a result that underscores the importance of timing imagery to coincide with more favorable vegetation maturity. The north pond with the June image using SR and the exponential function (R{sup 2}=0.603) proved to be the best predictor of swamp timothy seed productivity. The June image for the south pond was less predictive, with TSAVI and the exponential function providing the best correlation (R{sup 2}=0.448). This result was attributed to insufficient vegetal cover in the south pond (or a higher percentage of bare soil) due to poor drainage conditions which resulted in a delay in swamp timothy germination. The results of this work suggest that spectral reflectance can be used to estimate seed productivity in managed seasonal

  18. Application of the N/D-method to the Roy equations

    International Nuclear Information System (INIS)

    Heemskerk, A.C.

    1978-01-01

    The subject of this thesis is the study and numerical application of the Roy equations for elastic pion-pion scattering. These equations were introduced by S.M. Roy in 1971 and express the minimal requirements any ππ partial wave amplitude should satisfy, such as analyticity and crossing symmetry. When combined with the unitarity relations for the partial waves a complete system of equations (the Roy system) results valid in the low-energy region. The author has studied the existance and uniqueness question for the Roy system and developed successful strategies to solve the system by means of iteration. Several solutions are presented and discussed. The main ingredients in the present approach are a) the use of the N/D-method to regularize the singular Roy equations and implement unitarity and b) the introduction of various iteration methods which do not need any derivatives to solve the resulting nonlinear system of equations numerically. (Auth.)

  19. Roy-Steiner-equation analysis of pion-nucleon scattering

    Science.gov (United States)

    Meißner, U.-G.; Ruiz de Elvira, J.; Hoferichter, M.; Kubis, B.

    2017-03-01

    Low-energy pion-nucleon scattering is relevant for many areas in nuclear and hadronic physics, ranging from the scalar couplings of the nucleon to the long-range part of two-pion-exchange potentials and three-nucleon forces in Chiral Effective Field Theory. In this talk, we show how the fruitful combination of dispersion-theoretical methods, in particular in the form of Roy-Steiner equations, with modern high-precision data on hadronic atoms allows one to determine the pion-nucleon scattering amplitudes at low energies with unprecedented accuracy. Special attention will be paid to the extraction of the pion-nucleon σ-term, and we discuss in detail the current tension with recent lattice results, as well as the determination of the low-energy constants of chiral perturbation theory.

  20. Gleason-kahane-Żelazko theorem for spectrally bounded algebra

    Directory of Open Access Journals (Sweden)

    S. H. Kulkarni

    2005-01-01

    Full Text Available We prove by elementary methods the following generalization of a theorem due to Gleason, Kahane, and Żelazko. Let A be a real algebra with unit 1 such that the spectrum of every element in A is bounded and let φ:A→ℂ be a linear map such that φ(1=1 and (φ(a2+(φ(b2≠0 for all a, b in A satisfying ab=ba and a2+b2 is invertible. Then φ(ab=φ(aφ(b for all a, b in A. Similar results are proved for real and complex algebras using Ransford's concept of generalized spectrum. With these ideas, a sufficient condition for a linear transformation to be multiplicative is established in terms of generalized spectrum.

  1. Clinical studies of a purified timothy pollen extract: desensitization therapy with a purified timothy pollen preparation compared to a crude timothy pollen extract. II. Results of the tests in vitro and their relation to symptoms and tests in vivo.

    Science.gov (United States)

    Nordvall, S L; Berg, T; Johansson, S G; Lanner, A

    1982-01-01

    Perennial desensitization therapy was given during a period of 3.5 years to 40 children allergic to grass pollen allergens. 20 patients were treated with a crude and another 20 with a purified timothy pollen extract. 8 children served as untreated controls. The concentration of total and specific IgE in the treated groups covaried with those in the control group. Neither a suppression of the seasonal booster effect nor a suppression of IgE synthesis attributable to the treatment was found. The rise of timothy-specific "blocking' IgG antibodies was more pronounced in the group treated with the purified extract than in the group treated with the crude extract. A significant difference was found only after 3.5 years of treatment. The amplitude of rise of IgG antibodies correlated significantly with the effect of the treatment as judged by repeated conjunctival titration test. The results suggest that a good IgG response is an indication of successful therapy and that a better IgG response may be achieved with purified allergen extracts.

  2. The relation of serum PSA and Gleason's grade in patients with prostacic carcinoma

    Directory of Open Access Journals (Sweden)

    Živković Slađana

    2003-01-01

    Full Text Available The prostatic adenocarcinoma is one of the most frequent malignant tumors of men over 50 years of age. It is distinguished by agressive clinical course and heterogeneous multifocal hystomorphologic changes. PSA is the most reliable serum marker in diagnostics and observation of prostatic carcinoma and gleason's system of tumor-diferentiation grading is generally accepted way of determining the hystologic grade. Gleason's system is correlated with serum levels of PSA and with biological behaviour of the tumor. We presented 40 patients with verified ACP in whom the level of serum PSA, gleason's grade and score were compared. Highly significant correlation was found between serum level of PSA and the differentation grade of the tumor - Gleason's grade and score. Combination of PSA parameters and Gleason's score enables correct estimation of tumor's behaviour and correct therapeutic protocole.

  3. Roy-Steiner equations for pion-nucleon scattering

    Science.gov (United States)

    Ditsche, C.; Hoferichter, M.; Kubis, B.; Meißner, U.-G.

    2012-06-01

    Starting from hyperbolic dispersion relations, we derive a closed system of Roy-Steiner equations for pion-nucleon scattering that respects analyticity, unitarity, and crossing symmetry. We work out analytically all kernel functions and unitarity relations required for the lowest partial waves. In order to suppress the dependence on the high energy regime we also consider once- and twice-subtracted versions of the equations, where we identify the subtraction constants with subthreshold parameters. Assuming Mandelstam analyticity we determine the maximal range of validity of these equations. As a first step towards the solution of the full system we cast the equations for the π π to overline N N partial waves into the form of a Muskhelishvili-Omnès problem with finite matching point, which we solve numerically in the single-channel approximation. We investigate in detail the role of individual contributions to our solutions and discuss some consequences for the spectral functions of the nucleon electromagnetic form factors.

  4. A Biography Between Spaces: M.N. Roy, from Indian nationalism to Mexican communism

    Directory of Open Access Journals (Sweden)

    Michael Goebel

    2013-04-01

    Full Text Available This paper traces the global travels of Indian revolutionary Manabendra Nath Roy (1884-1954, with special attention to the tension between nationalism and communism in his transnational political writings and networks. In particular, the article examines Roy's sojourn in revolutionary Mexico between 1917 and 1920, time during which he approached Marxism and signed as one of the founders of the Mexican Communist Party. The paper is therefore based on Roy's own writings, as well as on German and British diplomatic documents. The example of Roy's trajectory is used here to advance a number of more general arguments of theoretical nature regarding the advantages and problems of a transnational  historiography and its relation to biography as a historiographical genre.

  5. Adolescent Girls' Self-Concept and Its Related Factors Based on Roy Adaptation Model

    OpenAIRE

    M. Basiri Moghadam; SH. Khosravan; L. Sadeghmoghadam; N. Ebrahimi Senoo

    2017-01-01

    Aims: One of the most important factors of individual health in the adolescents is the self-concept. As a nursing model, the Roy adaptation model mainly investigates the factor. The aim of the study was to investigate the self-concept and its related factors in the adolescent girls in Gonabad Township, based on the Roy adaptation model. Instrument & Methods: In the descriptive cross-sectional study, 270 adolescent girls were studied in Gonabad Township, Iran, in 2015. The subjects were s...

  6. Incidence of Extraprostatic Extension at Radical Prostatectomy with Pure Gleason Score 3 + 3 = 6 (Grade Group 1) Cancer: Implications for Whether Gleason Score 6 Prostate Cancer Should be Renamed "Not Cancer" and for Selection Criteria for Active Surveillance.

    Science.gov (United States)

    Hassan, Oudai; Han, Misop; Zhou, Amy; Paulk, Adina; Sun, Yue; Al-Harbi, Abdullah; Alrajjal, Ahmed; Baptista Dos Santos, Filipa; Epstein, Jonathan I

    2018-06-01

    We assessed the risk of locally aggressive behavior in pure Gleason score 6 (Grade Group 1) prostate cancer using contemporary grading criteria. To our knowledge this has been studied in only 1 prior cohort. We evaluated consecutive radical prostatectomy specimens from an academic institution, including those from 3,291 men with Gleason score 6 and 4,202 with Gleason score 3 + 4 = 7 (Grade Group 2) disease between 2005 and 2016. For dichotomous variables the Pearson chi-square test was used. Of the 3,288 Gleason score 6 cancer cases 128 (3.9%) showed focal extraprostatic extension compared to 593 of the 4,202 (14.1%) with Gleason score 3 + 4 = 7 (p <0.0001). Of the 3,288 Gleason score 6 cancer cases 79 (2.4%) showed nonfocal extraprostatic extension compared to 639 of the 4,202 (15.2%) with Gleason score 3 + 4 = 7 (p <0.0001). The incidence of focal extraprostatic extension with Gleason score 3 + 4 = 7 with less than 5% Gleason pattern 4 was 129 of 1,147 cases (11.2%), which was between Gleason scores 6 and 3 + 4 = 7 with greater than 5% Gleason pattern 4. The incidence of nonfocal extraprostatic extension in Gleason score 3 + 4 = 7 with less than 5% Gleason pattern 4 was 96 of 1,147 cases (8.4%), which was between Gleason scores 6 and 3 + 4 = 7 with greater than 5% Gleason pattern 4. One of the 3,290 Gleason score 6 cases (0.03%) showed seminal vesicle invasion compared to 93 of the 4,202 (2.2%) of Gleason score 3 + 4 = 7 (p <0.0001). A limitation of our study was its retrospective design. It is not rare for pure Gleason score 6 prostate cancer to locally extend out of the prostate 3.9% focally and 2.4% nonfocally. In extremely rare cases Gleason score 6 can be associated with seminal vesicle invasion and yet not lymph node metastases. Our overall findings support the argument for continuing to use the term cancer for these tumors. Copyright © 2018 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  7. Bringing critical realism to nursing practice: Roy Bhaskar's contribution.

    Science.gov (United States)

    Williams, Lynne; Rycroft-Malone, Jo; Burton, Christopher R

    2017-04-01

    In the context of modern nursing practice that is embedded within complex social situations, critical discussions about the contribution of major philosophers are relevant and important. Whilst nurse theorists have advanced and shaped nursing as a discipline, other major philosophers can offer much to advance nursing enquiry. In this paper, we focus on philosopher Roy Bhaskar who, amongst others, developed critical realism, a philosophy for social science which connects with how many of us think about the world. Bhaskar's work focuses our attention on the interplay between structure and agency and on the search for the causative or generative mechanisms that explain the social world. Bhaskar was interested in human emancipation, and we suggest his work is of great importance to advance understanding of complex social situations. Critical realism has already been endorsed by a range of disciplines, especially in research which focuses on real problems and acknowledges the complexities of the social world. In recent evidence from healthcare literature, there has been a surge in research using realist methodology (realist evaluation and realist synthesis), which is underpinned by the philosophy of critical realism and which offers a different perspective to understanding nursing and healthcare problems through the realist lens. However, we suggest that sufficient attention is not always paid to the philosophical roots of this methodology. In this paper, we provide insight into Bhaskar's work and demonstrate how research positioned within critical realism and realist methodology can advance nursing and healthcare-related knowledge. Through shining a light on Bhaskar, we illustrate how critical realism philosophy is a natural fit with human and health science enquiry, including nursing. © 2016 John Wiley & Sons Ltd.

  8. A Critique of Timothy Vang’s Hmong Religious Conversion and Resistance Study

    Directory of Open Access Journals (Sweden)

    Nao Xiong

    2009-01-01

    Full Text Available We review Timothy Vang’s dissertation on the growth and decline of the Hmong Christian church. We argue that Vang’s arguments are methodologically and theoretically flawed. Furthermore, we try to show that his dissertation is not so much an objective analysis of Hmong religious adaptation, but rather an attempt to define and subjugate certain Hmong cultural and religious beliefs and practices as backward and inferior to Christianity. We suggest that it is these kinds of problematic arguments, often couched in academic language, that further perpetuate misinterpretations and misrepresentations about “culture” and “religion” in Hmong American communities.

  9. Higher Prostate Weight Is Inversely Associated with Gleason Score Upgrading in Radical Prostatectomy Specimens

    Directory of Open Access Journals (Sweden)

    Leonardo Oliveira Reis

    2013-01-01

    Full Text Available Background. Protective factors against Gleason upgrading and its impact on outcomes after surgery warrant better definition. Patients and Methods. Consecutive 343 patients were categorized at biopsy (BGS and prostatectomy (PGS as Gleason score, ≤6, 7, and ≥8; 94 patients (27.4% had PSA recurrence, mean followup 80.2 months (median 99. Independent predictors of Gleason upgrading (logistic regression and disease-free survival (DFS (Kaplan-Meier, log-rank were determined. Results. Gleason discordance was 45.7% (37.32% upgrading and 8.45% downgrading. Upgrading risk decreased by 2.4% for each 1 g of prostate weight increment, while it increased by 10.2% for every 1 ng/mL of PSA, 72.0% for every 0.1 unity of PSA density and was 21 times higher for those with BGS 7. Gleason upgrading showed increased clinical stage (P=0.019, higher tumor extent (P=0.009, extraprostatic extension (P=0.04, positive surgical margins (P<0.001, seminal vesicle invasion (P=0.003, less “insignificant” tumors (P<0.001, and also worse DFS, χ2=4.28, df=1, P=0.039. However, when setting the final Gleason score (BGS ≤6 to PGS 7 versus BGS 7 to PGS 7, avoiding allocation bias, DFS impact is not confirmed, χ2=0.40, df=1, P=0.530.Conclusions. Gleason upgrading is substantial and confers worse outcomes. Prostate weight is inversely related to upgrading and its protective effect warrants further evaluation.

  10. The impact of the 2005 International Society of Urological Pathology consensus guidelines on Gleason grading

    DEFF Research Database (Denmark)

    Berg, Kasper D; Thomsen, Frederik B; Nerstrøm, Camilla

    2016-01-01

    .5 years in the pre-ISUP group and 4.8 years in the post-ISUP group. The 5-year cumulative incidences of BCR were 34.0% and 13.9% in the pre-ISUP and post-ISUP groups, respectively (P 4) (P...... = 0.004). There was no difference in the 5-year cumulative incidence of BCR between patients with pre-ISUP Gleason score 6 and post-ISUP Gleason score 7 (3 + 4) (P = 0.34). In a multiple Cox-proportional hazard regression model, ISUP 2005 grading was a strong prognostic factor for BCR within 5 years...... as Gleason score 6 (3 + 3) are now considered as 7 (3 + 4). PATIENTS AND METHODS: A matched-pair analysis was conducted. In all, 215 patients with Gleason score 6 or 7 (3 + 4) prostate cancer on biopsy who underwent RP before 31 December 2005 (pre-ISUP group), were matched 1:1 by biopsy Gleason score...

  11. Savonarola at the stake: the rise and fall of Roy Meadow.

    Science.gov (United States)

    Kaplan, Robert

    2008-06-01

    The aim of this paper is to describe the role of prominent paediatrician Professor Sir Roy Meadow in the controversy surrounding the diagnosis of Munchausen Syndrome by Proxy (MSBP) in mothers accused of murdering their children. The MSBP saga is a further chapter of an era of moral panic that started several decades ago with repressed memory therapy, satanic ritual abuse and multiple personalities. The fall of medieval sage Savonarola is an apt analogy for the fate of Roy Meadow. The history of medicine is rife with figures who become their own authority and rule by force of personality.

  12. The Roy Adaptation Model: A Theoretical Framework for Nurses Providing Care to Individuals With Anorexia Nervosa.

    Science.gov (United States)

    Jennings, Karen M

    Using a nursing theoretical framework to understand, elucidate, and propose nursing research is fundamental to knowledge development. This article presents the Roy Adaptation Model as a theoretical framework to better understand individuals with anorexia nervosa during acute treatment, and the role of nursing assessments and interventions in the promotion of weight restoration. Nursing assessments and interventions situated within the Roy Adaptation Model take into consideration how weight restoration does not occur in isolation but rather reflects an adaptive process within external and internal environments, and has the potential for more holistic care.

  13. MR spectroscopy of prostate cancer: correlation study of metabolic characters with Gleason score

    International Nuclear Information System (INIS)

    Wang Xiaoying; Li Feiyu; Jiang Xuexiang; Shan Gangzhi; Zhou Liangping; Ding Jianping

    2006-01-01

    Objective: Using magnetic resonance spectroscopy (MRS) to measure the metabolic ratio [(choline + creatine)/citrate, CC/C] of prostate cancer(PCa) and to probe the correlation between the value of CC/C ratio and Gleason score. Methods: Twenty-one cases of PCa proved by operation or systemic biopsy were examined by MRS. The prostate was divided into 6 regions (left/right bottom, middle and tip), and the CC/C value of each region was measured. After biopsy, all the puncture locations were marked and enrolled in one of the regions mentioned above and the Gleason scores were recorded. The ratio of CC/C measured by MRS was compared with Gleason score in the corresponding regions. Results: The average CC/C ratio of the 74 regions with PCa was 2.13±0.82, whereas the average CC/C ratio of the 52 regions without PCa was 0.59±0.20. The difference of CC/C value was statistically significant (t=7.72, P=0.00). The ratios of CC/C in the regions of PCa were correlated with Gleason score (r=0.659, P=0.01). In group 1 (Gleason score≥7), the average CC/C ratio was 2.61±0.79. However, in group 2 (Gleasonscore <7) the average CC/C ratio was 1.69±0.59. There was statistically difference between the two groups (t=3.06, P=0.01). Conclusion: The metabolic ratio of CC/C is correlated to the Gleason score of PCa. MRS may be a useful method to evaluate the malignancy of PCa noninvasively. (authors)

  14. A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason Score

    Science.gov (United States)

    Epstein, Jonathan I.; Zelefsky, Michael J.; Sjoberg, Daniel D.; Nelson, Joel B.; Egevad, Lars; Magi-Galluzzi, Cristina; Vickers, Andrew J.; Parwani, Anil V.; Reuter, Victor E.; Fine, Samson W.; Eastham, James A.; Wiklund, Peter; Han, Misop; Reddy, Chandana A.; Ciezki, Jay P.; Nyberg, Tommy; Klein, Eric A.

    2016-01-01

    Background Despite revisions in 2005 and 2014, the Gleason prostate cancer (PCa) grading system still has major deficiencies. Combining of Gleason scores into a three-tiered grouping (6, 7, 8–10) is used most frequently for prognostic and therapeutic purposes. The lowest score, assigned 6, may be misunderstood as a cancer in the middle of the grading scale, and 3 + 4 = 7 and 4 + 3 = 7 are often considered the same prognostic group. Objective To verify that a new grading system accurately produces a smaller number of grades with the most significant prognostic differences, using multi-institutional and multimodal therapy data. Design, setting, and participants Between 2005 and 2014, 20 845 consecutive men were treated by radical prostatectomy at five academic institutions; 5501 men were treated with radiotherapy at two academic institutions. Outcome measurements and statistical analysis Outcome was based on biochemical recurrence (BCR). The log-rank test assessed univariable differences in BCR by Gleason score. Separate univariable and multivariable Cox proportional hazards used four possible categorizations of Gleason scores. Results and limitations In the surgery cohort, we found large differences in recurrence rates between both Gleason 3 + 4 versus 4 + 3 and Gleason 8 versus 9. The hazard ratios relative to Gleason score 6 were 1.9, 5.1, 8.0, and 11.7 for Gleason scores 3 + 4, 4 + 3, 8, and 9–10, respectively. These differences were attenuated in the radiotherapy cohort as a whole due to increased adjuvant or neoadjuvant hormones for patients with high-grade disease but were clearly seen in patients undergoing radiotherapy only. A five–grade group system had the highest prognostic discrimination for all cohorts on both univariable and multivariable analysis. The major limitation was the unavoidable use of prostate-specific antigen BCR as an end point as opposed to cancer-related death. Conclusions The new PCa grading system has these benefits: more

  15. Nursing Approach Based on Roy Adaptation Model in a Patient Undergoing Breast Conserving Surgery for Breast Cancer.

    Science.gov (United States)

    Ursavaş, Figen Erol; Karayurt, Özgül; İşeri, Özge

    2014-07-01

    The use of models in nursing provides nurses to focus on the role of nursing and its applications rather than medical practice. In addition, it helps patient care to be systematic, purposeful, controlled and effective. One of the commonly used models in nursing is Roy Adaptation Model. According to Roy adaptation model, the aim of nursing is to increase compliance and life expectancy. Roy Adaptation Model evaluates the patient in physiologic mode, self-concept mode, role function mode and interdependence mode aiming to provide holistic care. This article describes the use of Roy Adaptation Model in the care of a patient who has been diagnosed with breast cancer and had breast-conserving surgery. Patient data was evaluated in the four modes of Roy adaptation model (physiologic, self-concept, role function, and interdependence modes) and the nursing process was applied.

  16. Elujõuline Eesti etnoloogia / Terje Anepaio, Aivar Jürgenson, Timothy King, Art Leete ; interv. Maarja Kaaristo

    Index Scriptorium Estoniae

    2006-01-01

    Etnoloogia hetkeseisu ja tuleviku üle arutlevad Eesti Rahva Muuseumi teadusdirektor Terje Anepaio, Ajaloo Instituudi etnoloogia osakonna juhataja vanemteadur Aivar Jürgenson, Tallinna Ülikooli antropoloogia õppekava juht Timothy King ja Tartu Ülikooli etnoloogia õppetooli professor Art Leete

  17. Roy Reider (1914-1979) selections from his written and spoken words

    International Nuclear Information System (INIS)

    Paxton, H.C.

    1980-01-01

    Comments by Roy Reider on chemical criticality control, the fundamentals of safety, policy and responsibility, on written procedures, profiting from accidents, safety training, early history of criticality safety, requirements for the possible, the value of enlightened challenge, public acceptance of a new risk, and on prophets of doom are presented

  18. Effect of Treatment Education Based on the Roy Adaptation Model on Adjustment of Hemodialysis Patients.

    Science.gov (United States)

    Kacaroglu Vicdan, Ayse; Gulseven Karabacak, Bilgi

    2016-01-01

    The Roy Adaptation Model examines the individual in 4 fields: physiological mode, self-concept mode, role function mode, and interdependence mode. Hemodialysis treatment is associated with the Roy Adaptation Model as it involves fields that might be needed by the individual with chronic renal disease. This research was conducted as randomized controlled experiment with the aim of determining the effect of the education given in accordance with the Roy Adaptation Model on physiological, psychological, and social adaptation of individuals undergoing hemodialysis treatment. This was a random controlled experimental study. The study was conducted at a dialysis center in Konya-Aksehir in Turkey between July 1 and December 31, 2012. The sample was composed of 82 individuals-41 experimental and 41 control. In the second interview, there was a decrease in the systolic blood pressures and body weights of the experimental group, an increase in the scores of functional performance and self-respect, and a decrease in the scores of psychosocial adaptation. In the control group, on the other hand, there was a decrease in the scores of self-respect and an increase in the scores of psychosocial adaptation. The 2 groups were compared in terms of adaptation variables and a difference was determined on behalf of the experimental group. The training that was provided and evaluated for individuals receiving hemodialysis according to 4 modes of the Roy Adaptation Model increased physical, psychological, and social adaptation.

  19. COMPLEX STAGING : THE HIDDEN DIMENSIONS OF ROY ANDERSSON’S AESTHETICS

    NARCIS (Netherlands)

    Hanich, Julian

    2014-01-01

    In this essay I follow André Bazin and David Bordwell and their discussion of the deep-focus long-take as well as staging in depth. I have three goals. First, I engage with the style of Swedish director Roy Andersson. Andersson – born in 1943 and best known for his films Songs from the Second Floor

  20. Conceivability and De Re Modal Knowledge: A reply to Roca-Royes

    DEFF Research Database (Denmark)

    Steffensen, Asger Bo Skjerning

    In a recent paper, Roca-Royes argues that conceivability cannot be the whole story about our access to de re modal knowledge. Her claim is that conceivability-based epistemologies fails to comply with a principle any epistemology of de re modality must observe. I critically assess Roca...

  1. „Skrwawione ziemie” Timothy Snydera. Krytyczne uwagi na temat konstrukcji krajobrazu historycznego

    Directory of Open Access Journals (Sweden)

    Jürgen Zarusky

    2012-12-01

    Full Text Available Timothy Snyder’s "Bloodlands". Critical comments on the construction of historical landscape Jürgen Zarusky's text is an extensive deconstruction of Timothy Snyder's narration presented in Bloodlands. The narration is based on the assumption, that both regimes – Nazi and Soviet – and their extermination practicies were similar. In Bloodlands Stalin's crimes are presented as a form of ethnic extermination. Thus Snyder suggested ideological kinship between both dictators without analysing specific ideologies. Although the author specifies the differences between these two ideologies he does not ask about their significance to the enemy image and extermination practicies. Snyder's narration concentrates excessively on Poland – as the core of “bloodlands”. In the closing chapter of the book Poles are depicted as the actual martyrs of “bloodlands” in Poland, as well as on the territory of the Soviet Union. Yet up to this day there are ethinc gorups – like Sinti and Romany -  who have to fight for the recognition of their tragic experiences as the victims of crimes commited by German authorities. The author also does not mention about the victims of the agressive wars against the Soviet Union. Thus the point of Bloodlands is not to present all the victims of totalitarianism and the war, all the victims from “bloodlands”, but to present only the victims selected by the author.   „Skrwawione ziemie” Timothy Snydera. Krytyczne uwagi na temat konstrukcji krajobrazu historycznego Tekst Jürgen Zarusky'ego to obszerna dekonstrukcja narracji Timothy Snydera zaprezentowanej w książce Skrwawione ziemie. Zasadza się ona na założeniu, że oba reżimy - niemiecki i radziecki - oraz ich praktyki eksterminacyjne były bardzo do siebie zbliżone. W książce przedstawiono stalinowskie zbrodnie masowe jako formę etnicznej eksterminacji. W ten sposób Snyder zasugerował ideologiczne pokrewieństwo między obu dyktatorami, nie

  2. Score de Gleason des biopsies prostatiques et celui des pièces de prostatectomies: Quelle corrélation?

    Directory of Open Access Journals (Sweden)

    A. Qarro

    2012-12-01

    Conclusion: Le score de Gleason biopsique influence la décision thérapeutique dans le cancer de prostate localisé. Cependant, il ne reflète pas toujours le score de Gleason de la pièce de prostatectomie, en particulier dans les groupes bien différenciés.

  3. Failure of cellulolysis in the rumen of reindeer fed timothy silage

    Directory of Open Access Journals (Sweden)

    Monica A. Olsen

    1995-01-01

    Full Text Available Three male reindeer (Rangifer tarandus tarandus calves were brought from mountain pastures in April and fed regrowth timothy (Phleum pratense silage with 76% leaves and 24.0% dry matter (DM ad libitum. The silage contained (on DM basis 25.4% cellulose, 12.0% crude protein and 19-6% water soluble carbohydrates. After an initial period of 11 days the daily silage intake rose to almost similar values for all animals, but independently of food intake, body mass (BM increased by as much as 13.3 kg for animal R3 during the first 21 days, compared to 4.4 kg and 2.8 kg for Rl and R2, respectively. At slaughter the wet weight of the rumen contents of animal R3 constituted 30.2% of the total BM, compared to 18.5% and 19.1% in animals Rl and R2, respectively. A reduced ability of the rumen micro-biota to ferment pure cellulose in vitro was observed in R3. The ruminal pH was 7.07 and the concentration of volatile fatty acids was only 50.0 mM in R3, indicating a low rate of fermentation. The initial rates of in vitro dry matter digestibility of timothy silage and standard hay were also affected by the rumen fermentation failure in animal R3. Depressed rumen cellulolysis, which may be related to natural periods of starvation prior to the feeding experiment, could have caused the low rate of fermentation and the large rumen size observed in this animal.

  4. Color/power Doppler transrectal US in prostate cancer: Correlation with Gleason score

    International Nuclear Information System (INIS)

    Kim, Hyo Cheol; Kim, Seung Hyup; Moon, Min Hoan; Park, Byung Kwan; Kim, Keon Ha; Choi, Hyuck Jae; Yoon, Chang Jin

    2002-01-01

    To evaluate the relationship between hypervascularity on color/power Doppler transrectal ultrasonography and the Gleason score of corresponding biopsied specimen in patients with prostatic cancer. From July 1998 to March 2002, one hundred fifty seven patients with pathologically proven prostate cancer at this institution were included, and all of them underwent transrectal ultrasonographic examination. Initially, ultrasonographic findings and pathologic data of 129 patients were retrospectively reviewed and excluded 28 patients whose sonographic images were either unavailable or inconclusive. The presence of hypoechoic lesion on transrectal sonography and hypervascularity on color/power Doppler sonography in the peripheral zone of the prostate was first evaluated, and these sonographic findings and Gleason score of the corresponding biopsied specimen were then compared. Statistical analysis was done by Student t-test using SPSS package. Among one hundred twenty nine patients, ninety four patients had a hypoechoic lesion on gray scale sonography while sixty one showed a hypervascular lesion on color/power Doppler sonography. Fifty seven of 61 patients (93.4%) had hypoechoic lesion on gray scale sonography. The mean Gleason score of patients with hypervascular lesion was 7.9 ± 0.98 whereas that of the patients without hypervascular lesion, 6.9 ± 1.22, showing a statistically significant difference (p<0.01). Prostate cancer with hypervascularity on transrectal sonography appears to have a higher Gleason score on pathologic examination than that without hypervascularity.

  5. Analysis of Gleason grade and scores in 90 Nigerian Africans with ...

    African Journals Online (AJOL)

    Histology sections 4-5microns thick were cut from paraffin blocks and stained by Haematoxylin and Eosin (H&E). Histopathologic specimens were classified using the grading system of tumour differentiation described by Gleason and associates. Results: One hundred and twenty three cancers of the prostate were received, ...

  6. Correlation between PSA, bone scan and Gleason score in patients with prostate cancer

    International Nuclear Information System (INIS)

    Mendoza, G.; Cano, R.; Morales, R.; Munoz, L.; Saavedra, P.; Aguilar, C.

    2004-01-01

    Full text: Prostate cancer is the third most common cancer among Peruvian males. Although radionuclide bone scans (BS) are frequently recommended as part of the staging evaluation for newly diagnosed prostate cancer, most scans are negative for metastases. It has been suggested that a routine bone scan is unnecessary in recently diagnosed prostate cancer if serum PSA is under 10 ng/mL. We hypothesized that Gleason score plus prostate-specific antigen (PSA), could predict for a positive bone scan (better that PSA alone), and that a low - risk group of patients could be identified in whom BS might be omitted. All patients who had both pathologic review of their prostate cancer biopsies and radionuclide BS at our institution from 1/93 to 12/95 were studied. Gleason score, PSA, and bone scan (Soloway Index) were determined in 165 patients. Bivariate analysis using chi (x2) was performed. The mean age of the 165 patients was 71.3 years, 109/165 (66.1%) had a 7-9 Gleason score and only 9/165 (5.5%) were well differentiated prostrate cancer. 82/165 (49.7%) had negative BS. When classifying patients according to their histological grade, the PSA median values were 11.8 ng/mL, 74.8 ng/mL and 116.4 ng/mL in well, median and poorly differentiated prostate cancer respectively. Using a cut off point of 10 ng/mL of PSA, the probability of having a positive BS in Gleason 7, 8 and 9 tumors were 0.109, 0.121 and 0.133 respectively. By using a cut off point of 20 ng/mL of PSA the possibility to have a positive BS in Gleason 7, 8 and 9 tumours were 0.182, 0.206 and 0.224 respectively. Gleason score plus PSA were independent predictors for a positive radionuclide BS in newly diagnosed prostate cancer patients. Considering that most of our patients have Gleason 7-9, the risk of bone metastases despite PSA levels between 10 - 20 ng/mL is not negligible. In our opinion, it is important to continue including bone scan in the staging assessment of prostate cancer. (author)

  7. Statistical Shape Model for Manifold Regularization: Gleason grading of prostate histology.

    Science.gov (United States)

    Sparks, Rachel; Madabhushi, Anant

    2013-09-01

    Gleason patterns of prostate cancer histopathology, characterized primarily by morphological and architectural attributes of histological structures (glands and nuclei), have been found to be highly correlated with disease aggressiveness and patient outcome. Gleason patterns 4 and 5 are highly correlated with more aggressive disease and poorer patient outcome, while Gleason patterns 1-3 tend to reflect more favorable patient outcome. Because Gleason grading is done manually by a pathologist visually examining glass (or digital) slides subtle morphologic and architectural differences of histological attributes, in addition to other factors, may result in grading errors and hence cause high inter-observer variability. Recently some researchers have proposed computerized decision support systems to automatically grade Gleason patterns by using features pertaining to nuclear architecture, gland morphology, as well as tissue texture. Automated characterization of gland morphology has been shown to distinguish between intermediate Gleason patterns 3 and 4 with high accuracy. Manifold learning (ML) schemes attempt to generate a low dimensional manifold representation of a higher dimensional feature space while simultaneously preserving nonlinear relationships between object instances. Classification can then be performed in the low dimensional space with high accuracy. However ML is sensitive to the samples contained in the dataset; changes in the dataset may alter the manifold structure. In this paper we present a manifold regularization technique to constrain the low dimensional manifold to a specific range of possible manifold shapes, the range being determined via a statistical shape model of manifolds (SSMM). In this work we demonstrate applications of the SSMM in (1) identifying samples on the manifold which contain noise, defined as those samples which deviate from the SSMM, and (2) accurate out-of-sample extrapolation (OSE) of newly acquired samples onto a

  8. Clinical role of pathological downgrading after radical prostatectomy in patients with biopsy confirmed Gleason score 3 + 4 prostate cancer.

    Science.gov (United States)

    Gondo, Tatsuo; Poon, Bing Ying; Matsumoto, Kazuhiro; Bernstein, Melanie; Sjoberg, Daniel D; Eastham, James A

    2015-01-01

    To identify preoperative factors predicting Gleason score downgrading after radical prostatectomy (RP) in patients with biopsy Gleason score 3+4 prostate cancer and to determine if prediction of downgrading can identify potential candidates for active surveillance (AS). We identified 1317 patients with biopsy Gleason score 3+4 prostate cancers who underwent RP at the Memorial Sloan-Kettering Cancer Center between 2005 and 2013. Several preoperative and biopsy characteristics were evaluated by forward selection regression, and selected predictors of downgrading were analysed by multivariable logistic regression. Decision curve analysis was used to evaluate the clinical utility of the multivariate model. Gleason score was downgraded after RP in 115 patients (9%). We developed a multivariable model using age, prostate-specific antigen density, percentage of positive cores with Gleason pattern 4 cancer out of all cores taken, and maximum percentage of cancer involvement within a positive core with Gleason pattern 4 cancer. The area under the curve for this model was 0.75 after 10-fold cross validation. However, decision curve analysis revealed that the model was not clinically helpful in identifying patients who will downgrade at RP for the purpose of reassigning them to AS. While patients with pathological Gleason score 3 + 3 with tertiary Gleason pattern ≤4 at RP in patients with biopsy Gleason score 3 + 4 prostate cancer may be potential candidates for AS, decision curve analysis showed limited utility of our model to identify such men. Future study is needed to identify new predictors to help identify potential candidates for AS among patients with biopsy confirmed Gleason score 3 + 4 prostate cancer. © 2014 The Authors. BJU International © 2014 BJU International.

  9. Prognostic significance of Gleason score 7 (3+4 and Gleason score 7 (4+3 in prostatic adenocarcinoma in relation to clinical stage, androgen tissue status and degree of neuroendocrine differentiation

    Directory of Open Access Journals (Sweden)

    Mijović M.

    2014-01-01

    Full Text Available Prognosis and choice of treatment of adenocarcinoma of the prostate (ADCP directly depend on the numerous of predictive factors, among which the most important are summary histological tumor grade (Gleason score, which is the sum of the first and second dominant histological grade and clinical stage. According to recent research these factors include androgen tissue status and degree of neuroendocrine differentiation. The importance of the first and second dominant histological grade becomes particularly important in ADCP Gleason score 7. Tumors with worse prognosis considered to be ADCP of higher Gleason score, the advanced clinical stage, androgen independent tumors and tumors that show a higher degree of neuroendocrine differentiation. The aim of the study was to determine the predictive significance of ADCP Gleason score 7 (3+4 and ADCP Gleason score 7 (4+3 in relation to clinical stage, androgen tissue status and degree of focal neuroendocrine differentiation. The study included 33 ADCP of Gleason score 7,26 (78.79% ADCP 7 (3+4 and 7 (21.21% ADCP 7 (4+3. All tumors are most often diagnosed with stage D2, when there are already distant metastases. ADCP of Gleason score 7 (4+3 were diagnosed more often at this stage, among them there are more androgen independent tumors and they show a greater degree of focal neuroendocrine differentiation. All the results are in accordance with data from the literature suggesting that ADCP of Gleason score 7 (4+3 have a worse prognosis than ADCP of Gleason score 7 (3 +4.

  10. Radical prostatectomy and positive surgical margins: tumor volume and Gleason score predicts cancer outcome

    International Nuclear Information System (INIS)

    La Roca, Ricardo L.R. Felts de; Fonseca, Francisco Paula da; Cunha, Isabela Werneck da; Bezerra, Stephania Martins

    2013-01-01

    Introduction: positive surgical margins (PSMs) are common adverse factors to predict the outcome of a patient submitted to radical prostatectomy (PR). However, not all of these men will follow with biochemical (BCR) or clinical (CR) recurrence. Relationship between PSMs with these recurrent events has to be correlated with other clinicopathological findings in order to recognize more aggressive tumors in order to recommend complementary treatment to these selected patients. Materials and methods: we retrospectively reviewed the outcome of 228 patients submitted to open retropubic RP between March 1991 and June 2008, where 161 had and 67 did not have PSMs. Minimum follow-up time was considered 2 years after surgery. BCR was considered when PSA ≥ 0.2 ng/ml. CR was determined when clinical evidence of tumor appeared. Chi-square test was used to correlate clinical and pathologic variables with PSMs. The estimated 5-year risk of BCR and CR in presence of PSMs was determined using the Kaplan-Meier method and compared to log-rank tests. Results: from the total of 228 patients, 161 (71%) had PSMs, while 67 (29%) had negative surgical margins (NSMs). Prostatic circumferential margin was the most common (43.4%) site. Univariate analysis showed statistically significant (p < 0.001) associations between the presence of PSMs and BCR, but not with CR (p = 0.06). Among 161 patients with PSMs, 61 (37.8%) presented BCR, while 100 (62.8%) did not. Predicting progression-free survival for 5 years, BCR was correlated with pathological stage; Gleason score; pre-treatment PSA; tumor volume in specimen; capsular and perineural invasion; presence and number of PSMs. RC correlated only with angiolymphatic invasion and Gleason score. Considering univariate analyses the clinicopathological factors predicting BCR for 5 years, results statistically significant links with prostate weight; pre-treatment PSA; Gleason score; pathological stage; tumor volume; PSMs; capsular and perineural

  11. Radical prostatectomy and positive surgical margins: tumor volume and Gleason score predicts cancer outcome

    Energy Technology Data Exchange (ETDEWEB)

    La Roca, Ricardo L.R. Felts de, E-mail: Ricardo@delarocaurologia.com.br [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil); Fonseca, Francisco Paula da, E-mail: fpf@uol.com.br [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil). Divisao de Urologia. Dept. de Cirurgia Pelvica; Cunha, Isabela Werneck da; Bezerra, Stephania Martins, E-mail: iwerneck@gmail.com, E-mail: stephaniab@gmail.com [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil). Dept. de Patologia

    2013-07-01

    Introduction: positive surgical margins (PSMs) are common adverse factors to predict the outcome of a patient submitted to radical prostatectomy (PR). However, not all of these men will follow with biochemical (BCR) or clinical (CR) recurrence. Relationship between PSMs with these recurrent events has to be correlated with other clinicopathological findings in order to recognize more aggressive tumors in order to recommend complementary treatment to these selected patients. Materials and methods: we retrospectively reviewed the outcome of 228 patients submitted to open retropubic RP between March 1991 and June 2008, where 161 had and 67 did not have PSMs. Minimum follow-up time was considered 2 years after surgery. BCR was considered when PSA {>=} 0.2 ng/ml. CR was determined when clinical evidence of tumor appeared. Chi-square test was used to correlate clinical and pathologic variables with PSMs. The estimated 5-year risk of BCR and CR in presence of PSMs was determined using the Kaplan-Meier method and compared to log-rank tests. Results: from the total of 228 patients, 161 (71%) had PSMs, while 67 (29%) had negative surgical margins (NSMs). Prostatic circumferential margin was the most common (43.4%) site. Univariate analysis showed statistically significant (p < 0.001) associations between the presence of PSMs and BCR, but not with CR (p = 0.06). Among 161 patients with PSMs, 61 (37.8%) presented BCR, while 100 (62.8%) did not. Predicting progression-free survival for 5 years, BCR was correlated with pathological stage; Gleason score; pre-treatment PSA; tumor volume in specimen; capsular and perineural invasion; presence and number of PSMs. RC correlated only with angiolymphatic invasion and Gleason score. Considering univariate analyses the clinicopathological factors predicting BCR for 5 years, results statistically significant links with prostate weight; pre-treatment PSA; Gleason score; pathological stage; tumor volume; PSMs; capsular and perineural

  12. Responsiveness to timothy grass pollen in individuals without known natural exposure in an allergen challenge chamber.

    Science.gov (United States)

    Ramirez, Daniel A; Andrews, Charles P; Rather, Cynthia G; Jacobs, Robert L

    2015-03-01

    The responsiveness to a nonendemic grass species is unknown and cannot be research without an allergen challenge chamber. To determine the clinical responsiveness to timothy grass pollen (TGP) in participants without known natural exposure in an allergen challenge chamber (ACC). Of the 26 screened participants, 22 met screening criteria and completed the 2 chamber exposures. The study consisted of an initial screening visit that included a blood draw for serum specific IgE (ssIGE) to Bermuda grass pollen and TGP followed by a 4½-day run-in phase and two 3-hour ACC exposure visits. This study was performed early in the first week of December 2013, when no seasonal pollens were detected in San Antonio, Texas. Symptom scores were recorded at baseline and every 30 minutes. Of the 26 screened participants, 22 met the screening criteria and completed the 2 chamber exposures. Thirteen participants had always lived in South Texas without natural exposure, and 9 had previously lived in areas with TGP exposure. All participants tested positive to TGP and Bermuda grass pollen. Twelve and 13 of 22 had positive ssIgE test results to Timothy and Bermuda allergens, respectively, with 11 having positive results for both allergens. There were strong correlations among skin prick test size, a positive ssIgE test result, and high symptoms from TGP exposure. There was little difference in symptoms between those who had lived their entire lives in South Texas and those who had lived elsewhere. In Texas, where exposure to TGP is minimal, strongly positive SPT and ssIgE test results were predictors of high symptoms to TGP exposure. Never exposed participants in South Texas reacted to TGP similar to those who had previous natural exposure, suggesting that in vivo cross-reactivity may be higher than predicted by prior in vitro data and may allow the use in clinical trials of allergens not endemic to the locale of an ACC. Copyright © 2015 American College of Allergy, Asthma & Immunology

  13. Characteristics of modern Gleason 9/10 prostate adenocarcinoma: a single tertiary centre experience within the Republic of Ireland.

    LENUS (Irish Health Repository)

    O'Kelly, F

    2014-08-01

    The 2005 international society of urological pathology consensus statement on Gleason grading in prostate cancer revised Gleason scoring in clinical practice. The potential for grade migration with this refinement poses difficulties in interpreting historical series. We report the characteristics of a recent cohort of consecutive Gleason score 9 or 10 prostate cancers in our institution. The purpose of this study was to define the clinicopathologic variables and staging information for this high-risk population, and to identify whether traditional prostate staging techniques are adequate for this subcohort of men.

  14. The Generalized Roy Model and the Cost-Benefit Analysis of Social Programs*

    Science.gov (United States)

    Eisenhauer, Philipp; Heckman, James J.; Vytlacil, Edward

    2015-01-01

    The literature on treatment effects focuses on gross benefits from program participation. We extend this literature by developing conditions under which it is possible to identify parameters measuring the cost and net surplus from program participation. Using the generalized Roy model, we nonparametrically identify the cost, benefit, and net surplus of selection into treatment without requiring the analyst to have direct information on the cost. We apply our methodology to estimate the gross benefit and net surplus of attending college. PMID:26709315

  15. The Generalized Roy Model and the Cost-Benefit Analysis of Social Programs.

    Science.gov (United States)

    Eisenhauer, Philipp; Heckman, James J; Vytlacil, Edward

    2015-04-01

    The literature on treatment effects focuses on gross benefits from program participation. We extend this literature by developing conditions under which it is possible to identify parameters measuring the cost and net surplus from program participation. Using the generalized Roy model, we nonparametrically identify the cost, benefit, and net surplus of selection into treatment without requiring the analyst to have direct information on the cost. We apply our methodology to estimate the gross benefit and net surplus of attending college.

  16. Effect of nitrogen fertilization on the protein quality of timothy grass and silage

    Directory of Open Access Journals (Sweden)

    Liisa Syrjälä-Qvist

    1984-09-01

    Full Text Available Timothy grass given N fertilizer at the rates of 40, 80 and 120 kg N/ha was preserved in 3 glass-fibre silos of 0.4 m3. The crude protein content of DM in the grass increased with the increase of N fertilization as follows: N40 14.8 %, N80 18.4 % and N120 22.1 %, but the proportion of true protein in crude protein decreased: N40 82 %, N80 78 % and N120 76 %. The proportion of watersoluble N in the total N in the grass was: N40 27 %, N80 30 % and N120 33 %. The higher was the N fertilization level, the more rapidly was the protein of the grass degraded in the rumen. The amino acid profile of the protein was similar at all the N fertilization levels. The quality of all the silages was good. The NH3-N fraction of total N was 2.8—3.9 % and the proportion of water-soluble N in total N was 51—55 %, In silage the decrease during ensiling in the proportion of true protein in crude protein and the increase in the proportion of water-soluble N in total N were smaller than in the other silages. The rumen degradability of protein during the first two hours was also lowest in this silage.

  17. Prostate Cancer Patients' Understanding of the Gleason Scoring System: Implications for Shared Decision-Making.

    Science.gov (United States)

    Tagai, Erin K; Miller, Suzanne M; Kutikov, Alexander; Diefenbach, Michael A; Gor, Ronak A; Al-Saleem, Tahseen; Chen, David Y T; Fleszar, Sara; Roy, Gem

    2018-01-15

    The Gleason scoring system is a key component of a prostate cancer diagnosis, since it indicates disease aggressiveness. It also serves as a risk communication tool that facilitates shared treatment decision-making. However, the system is highly complex and therefore difficult to communicate: factors which have been shown to undermine well-informed and high-quality shared treatment decision-making. To systematically explore prostate cancer patients' understanding of the Gleason scoring system (GSS), we assessed knowledge and perceived importance among men who had completed treatment (N = 50). Patients were administered a survey that assessed patient knowledge and patients' perceived importance of the GSS, as well as demographics, medical factors (e.g., Gleason score at diagnosis), and health literacy. Bivariate analyses were conducted to identify associations with patient knowledge and perceived importance of the GSS. The sample was generally well-educated (48% with a bachelor's degree or higher) and health literate (M = 12.9, SD = 2.2, range = 3-15). Despite this, patient knowledge of the GSS was low (M = 1.8, SD = 1.4, range = 1-4). Patients' understanding of the importance of the GSS was moderate (M = 2.8, SD = 1.0, range = 0-4) and was positively associated with GSS knowledge (p decision-making. Future studies are needed to explore the potential utility of a simplified Gleason grading system and improved patient-provider communication.

  18. Automatic Gleason grading of prostate cancer using quantitative phase imaging and machine learning

    Science.gov (United States)

    Nguyen, Tan H.; Sridharan, Shamira; Macias, Virgilia; Kajdacsy-Balla, Andre; Melamed, Jonathan; Do, Minh N.; Popescu, Gabriel

    2017-03-01

    We present an approach for automatic diagnosis of tissue biopsies. Our methodology consists of a quantitative phase imaging tissue scanner and machine learning algorithms to process these data. We illustrate the performance by automatic Gleason grading of prostate specimens. The imaging system operates on the principle of interferometry and, as a result, reports on the nanoscale architecture of the unlabeled specimen. We use these data to train a random forest classifier to learn textural behaviors of prostate samples and classify each pixel in the image into different classes. Automatic diagnosis results were computed from the segmented regions. By combining morphological features with quantitative information from the glands and stroma, logistic regression was used to discriminate regions with Gleason grade 3 versus grade 4 cancer in prostatectomy tissue. The overall accuracy of this classification derived from a receiver operating curve was 82%, which is in the range of human error when interobserver variability is considered. We anticipate that our approach will provide a clinically objective and quantitative metric for Gleason grading, allowing us to corroborate results across instruments and laboratories and feed the computer algorithms for improved accuracy.

  19. Computer aided analysis of prostate histopathology images to support a refined Gleason grading system

    Science.gov (United States)

    Ren, Jian; Sadimin, Evita; Foran, David J.; Qi, Xin

    2017-02-01

    The Gleason grading system used to render prostate cancer diagnosis has recently been updated to allow more accurate grade stratification and higher prognostic discrimination when compared to the traditional grading system. In spite of progress made in trying to standardize the grading process, there still remains approximately a 30% grading discrepancy between the score rendered by general pathologists and those provided by experts while reviewing needle biopsies for Gleason pattern 3 and 4, which accounts for more than 70% of daily prostate tis- sue slides at most institutions. We propose a new computational imaging method for Gleason pattern 3 and 4 classification, which better matches the newly established prostate cancer grading system. The computer- aided analysis method includes two phases. First, the boundary of each glandular region is automatically segmented using a deep convolutional neural network. Second, color, shape and texture features are extracted from superpixels corresponding to the outer and inner glandular regions and are subsequently forwarded to a random forest classifier to give a gradient score between 3 and 4 for each delineated glandular region. The F1 score for glandular segmentation is 0.8460 and the classification accuracy is 0.83+/-0.03.

  20. Roy's Adaptation Model-Guided Education and Promoting the Adaptation of Veterans With Lower Extremities Amputation.

    Science.gov (United States)

    Azarmi, Somayeh; Farsi, Zahra

    2015-10-01

    Any defect in extremities of the body can affect different life aspects. The purpose of this study was to investigate the effect of Roy's adaptation model-guided education on promoting the adaptation of veterans with lower extremities amputation. In a randomized clinical trial, 60 veterans with lower extremities amputation referring to Kowsar Orthotics and Prosthetics Center of veterans clinic in Tehran, Iran, were recruited with convenience method and were randomly assigned to intervention and control groups during 2013 - 2014. For data collection, Roy's adaptation model questionnaire was used. After completing the questionnaires in both groups, maladaptive behaviors were determined in the intervention group and an education program based on Roy's adaptation model was implemented. After two months, both groups completed the questionnaires again. Data was analyzed with SPSS software. Independent t-test showed statistically significant differences between the two groups in the post-test stage in terms of the total score of adaptation (P = 0.001) as well as physiologic (P = 0.0001) and role function modes (P = 0.004). The total score of adaptation (139.43 ± 5.45 to 127.54 ± 14.55, P = 0.006) as well as the scores of physiologic (60.26 ± 5.45 to 53.73 ± 7.79, P = 0.001) and role function (20.30 ± 2.42 to 18.13 ± 3.18, P = 0.01) modes in the intervention group significantly increased, whereas the scores of self-concept (42.10 ± 4.71 to 39.40 ± 5.67, P = 0.21) and interdependence (16.76 ± 2.22 to 16.30 ± 2.57, P = 0.44) modes in the two stages did not have a significant difference. Findings of this research indicated that the Roy's adaptation model-guided education promoted the adaptation level of physiologic and role function modes in veterans with lower extremities amputation. However, this intervention could not promote adaptation in self-concept and interdependence modes. More intervention is advised based on Roy's adaptation model for improving the

  1. Regarding the Focal Treatment of Prostate Cancer: Inference of the Gleason Grade From Magnetic Resonance Spectroscopic Imaging

    International Nuclear Information System (INIS)

    Brame, Ryan S.; Zaider, Marco; Zakian, Kristen L.; Koutcher, Jason A.; Shukla-Dave, Amita; Reuter, Victor E.; Zelefsky, Michael J.; Scardino, Peter T.; Hricak, Hedvig

    2009-01-01

    Purpose: To quantify, as a function of average magnetic resonance spectroscopy (MRS) score and tumor volume, the probability that a cancer-suspected lesion has an elevated Gleason grade. Methods and Materials: The data consist of MRS imaging ratios R stratified by patient, lesion (contiguous abnormal voxels), voxels, biopsy and pathologic Gleason grade, and lesion volume. The data were analyzed using a logistic model. Results: For both low and high Gleason score biopsy lesions, the probability of pathologic Gleason score ≥4+3 increases with lesion volume. At low values of R a lesion volume of at least 15-20 voxels is needed to reach a probability of success of 80%; the biopsy result helps reduce the prediction uncertainty. At larger MRS ratios (R > 6) the biopsy result becomes essentially uninformative once the lesion volume is >12 voxels. With the exception of low values of R, for lesions with low Gleason score at biopsy, the MRS ratios serve primarily as a selection tool for assessing lesion volumes. Conclusions: In patients with biopsy Gleason score ≥4+3, high MRS imaging tumor volume and (creatine + choline)/citrate ratio may justify the initiation of voxel-specific dose escalation. This is an example of biologically motivated focal treatment for which intensity-modulated radiotherapy and especially brachytherapy are ideally suited.

  2. Differentiation among prostate cancer patients with Gleason score of 7 using histopathology whole-slide image and genomic data

    Science.gov (United States)

    Ren, Jian; Karagoz, Kubra; Gatza, Michael; Foran, David J.; Qi, Xin

    2018-03-01

    Prostate cancer is the most common non-skin related cancer affecting 1 in 7 men in the United States. Treatment of patients with prostate cancer still remains a difficult decision-making process that requires physicians to balance clinical benefits, life expectancy, comorbidities, and treatment-related side effects. Gleason score (a sum of the primary and secondary Gleason patterns) solely based on morphological prostate glandular architecture has shown as one of the best predictors of prostate cancer outcome. Significant progress has been made on molecular subtyping prostate cancer delineated through the increasing use of gene sequencing. Prostate cancer patients with Gleason score of 7 show heterogeneity in recurrence and survival outcomes. Therefore, we propose to assess the correlation between histopathology images and genomic data with disease recurrence in prostate tumors with a Gleason 7 score to identify prognostic markers. In the study, we identify image biomarkers within tissue WSIs by modeling the spatial relationship from automatically created patches as a sequence within WSI by adopting a recurrence network model, namely long short-term memory (LSTM). Our preliminary results demonstrate that integrating image biomarkers from CNN with LSTM and genomic pathway scores, is more strongly correlated with patients recurrence of disease compared to standard clinical markers and engineered image texture features. The study further demonstrates that prostate cancer patients with Gleason score of 4+3 have a higher risk of disease progression and recurrence compared to prostate cancer patients with Gleason score of 3+4.

  3. Correlation between apparent diffusion coefficient value on diffusion-weighted MR imaging and Gleason score in prostate cancer.

    Science.gov (United States)

    Wu, X; Reinikainen, P; Vanhanen, A; Kapanen, M; Vierikko, T; Ryymin, P; Hyödynmaa, S; Kellokumpu-Lehtinen, P-L

    2017-01-01

    To investigate whether diffusion-weighted imaging (DWI) apparent diffusion coefficient (ADC) correlates with prostate cancer aggressiveness and further to compare the diagnostic performance of ADC and normalized ADC (nADC: normalized to non-tumor tissue). Thirty pre-treatment patients (mean age, 69years; range: 59-78years) with prostate cancer underwent magnetic resonance imaging (MRI) examination, including DWI with three b values: 50, 400, and 800s/mm 2 . Both ADC and nADC were correlated with the Gleason score obtained through transrectal ultrasound-guided biopsy. The tumor minimum ADC (ADC min : the lowest ADC value within tumor) had an inverse correlation with the Gleason score (r=-0.43, Pcorrelated with the Gleason score (r=-0.52 and r=-0.55, P<0.01; respectively), and they were lower in patients with Gleason score 3+4 than those with Gleason score 3+3 (P<0.01; respectively). Receiver operating characteristic (ROC) analysis showed that the area under the ROC curve was 0.765, 0.818, or 0.833 for the ADC min , nADC min , or nADC mean ; respectively, in differentiating between Gleason score 3+4 and 3+3 tumors. Tumor ADC min , nADC min , and nADC mean are useful markers to predict the aggressiveness of prostate cancer. Copyright © 2016 Éditions françaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.

  4. Timothy Leary, Richard Alpert (Ram Dass) and the changing definition of psilocybin.

    Science.gov (United States)

    Wark, Colin; Galliher, John F

    2010-05-01

    This research focuses on the events leading to the 1968 U.S. federal prohibition of psilocybin. It is a study of duelling moral entrepreneurs-Timothy Leary and Richard Alpert vs. the Harvard University Administration. The goal is to show how the primary active compound in an ostensibly harmless fungus (the psilocybin mushroom) became controversial in less than a decade. We used books, newspapers, magazine articles and previously unpublished materials (including documents from the Harvard Archives) to analyze Leary and Alpert's lives and careers through the early 1970s. The prohibition of psilocybin in the U.S. was largely a product of Leary and Alpert's involvement in the "Harvard drug scandal" and their transformation from Harvard professors to countercultural icons. They tested the substance on a variety of human subjects and in doing so piqued the interest of Harvard undergraduates while drawing condemnation from other faculty and Harvard administrators. This case is theoretically interesting because unlike most illegal drugs, psilocybin was never linked to a threatening minority group, but to some of the nation's most privileged youth. The Harvard administrators were not really moral entrepreneurs but Leary and Alpert clearly were. Although they were far from being prohibitionists, they were self-righteous crusaders on different but equally holy missions for the good of young and minority Americans. Ironically, due to their successes the possession of psilocybin was criminalized under United States federal law in 1968 (Pub. L. No. 90-639, Stat. 1361 1968 and Boire, 2002). This case study demonstrates that crusaders can be successful in changing culture even when laws are passed in futile attempts to control their behaviour, just as Leary predicted. Copyright 2009 Elsevier B.V. All rights reserved.

  5. A Gleason-Type Theorem for Any Dimension Based on a Gambling Formulation of Quantum Mechanics

    Science.gov (United States)

    Benavoli, Alessio; Facchini, Alessandro; Zaffalon, Marco

    2017-07-01

    Based on a gambling formulation of quantum mechanics, we derive a Gleason-type theorem that holds for any dimension n of a quantum system, and in particular for n=2. The theorem states that the only logically consistent probability assignments are exactly the ones that are definable as the trace of the product of a projector and a density matrix operator. In addition, we detail the reason why dispersion-free probabilities are actually not valid, or rational, probabilities for quantum mechanics, and hence should be excluded from consideration.

  6. Fatty acid composition of ruminal digesta and longissimus muscle from lambs fed silage mixtures including red clover, sainfoin, and timothy.

    Science.gov (United States)

    Campidonico, L; Toral, P G; Priolo, A; Luciano, G; Valenti, B; Hervás, G; Frutos, P; Copani, G; Ginane, C; Niderkorn, V

    2016-04-01

    This work investigated the effects of feeding silage mixtures of a plant containing polyphenol oxidase (PPO; red clover [; RC]), a plant containing tannins (sainfoin [; SF]), and a grass species not containing these compounds (timothy [; T]) on ruminal and intramuscular (i.m.) fatty acids of lambs. Forty 4-mo-old castrated male Romane lambs, divided into 5 groups, received 1 of the following silages: 1) T (100%), 2) a binary mixture of timothy and tannin-containing sainfoin ( cv. Perly; 50:50 [T-SF]), 3) a binary mixture of timothy and PPO-containing red clover ( cv. Mervius; 50:50 [T-RC]), 4) a ternary mixture of timothy, sainfoin, and red clover containing both tannins and PPO (50:25:25, respectively [T-SF-RC]), and 5) a binary mixture of tannin-containing sainfoin and PPO-containing red clover (50:50 [SF-RC]). In the rumen digesta, the partial or total replacement of T with forage legumes was associated with greater concentrations of PUFA ( forage legumes in the silage favored the accumulation of 18:3 -3 ( Forage legumes decreased the -11 18:1 to 30% of T in rumen digesta ( Forage legumes decreased the total concentration of branched-chain fatty acids in the rumen digesta (on average, -28%; comparison with T. The dietary treatment tended to affect the proportion of MUFA ( = 0.081) and of PUFA ( = 0.079) in the i.m. fat of the LM, respectively, at the highest and lowest numerical value in the T group. The sum of -3 fatty acids was less in the T and T-SF groups compared with the mixture of legumes without T (SF-RC; comparison with lambs given T-RC, T-SF-RC, and SF-RC. Rumenic acid (-9 -11 CLA) was detected at a greater percentage in the LM from the animals fed the T silage compared with animals fed the T-SF-RC treatment ( = 0.004). Contrarily, -9 -12 -15 18:3 was found at a greater concentration in the muscle from lambs in the SF-RC treatment compared with lambs in the other treatments ( forage for growing lambs in terms of i.m. fatty acid composition.

  7. Feed intake, gastrointestinal system and body composition in reindeer calves fed early harvested first cut timothy silage (Phleum pratense

    Directory of Open Access Journals (Sweden)

    Harri J. Norberg

    1998-02-01

    Full Text Available Early harvested first cut (EFC timothy silage was fed to five reindeer calves (Rangifer tarandus tarandus L. taken from their natural summer pasture and brought to Tromsø for feeding trial. The calves were housed indoors in metabolism cages and fed EFC timothy silage ad lib. during the trial, which lasted from late November 1994 until the end of February 1995, when animals subsequently were slaughtered. Daily feed intake, gastrointestinal (GI anatomy, body weight and body composition of the animals were examined. Timothy silage {Phleum praténse was harvested 21 June, 1994 in Tromsø, prewilted and stored as round bales containing 97% leaves. The EFC silage contained 42.1% dry matter (DM, and 18.1% crude protein, 20.7% cellulose, 16.9% hemicellulose and 28.0% water soluble carbohydrates (WSC of DM. Mean feed intake (DM 24 hours after the trial started (day 1 was 9-4 g/kg body mass (BM (S.D.+ 3-9, while the mean daily DM intake during days 15-74 comprised 24.2 g/kg BM (S.D.+ 6.1. All animals except one gained body weight during the trial. The median (range BM at start and at slaughter was 48.5 kg (34.5¬58.0 kg and 50.0 kg (42.0-53.5 kg, respectively. Median (range carcass weight % of BM was 58.0% (51.2-58.7% and muscle index value 0.0132 (0.0106-0.0176. The median reticulo-rumen (RR content wet weight (WW was 4601 g (range 2697-5000 g comprising 9.3% of the BM, and 85.1% of the total gastrointestinal wet weight content. The median (range gastrointestinal tract weight was 14.1% of BM (10.7-16.4%. Based on feed intake during the trial and body composition at slaughtet we conclude that first cut timothy silage is suitable as emergency feed to reindeer, as long as it is harvested in early growth stage with high proportion of leaves.

  8. Oncologic control obtained after radical prostatectomy in men with a pathological Gleason score ≥ 8: a single-center experience.

    Science.gov (United States)

    Audenet, François; Comperat, Eva; Seringe, Elise; Drouin, Sarah J; Richard, François; Cussenot, Olivier; Bitker, Marc-Olivier; Rouprêt, Morgan

    2011-01-01

    To assess the oncologic control afforded by radical prostatectomy (RP) in high-risk prostate cancers with a Gleason score ≥ 8. We performed a retrospective review of prostate cancer patients who underwent RP between 1995 and 2005 for prostate cancer and who had a pathologic Gleason score ≥ 8. Biochemical recurrence was defined as a single rise in PSA levels over 0.2 ng/ml after surgery. Overall, 64 patients were included and followed for a median time of 84.3 months. The mean age was 63 ± 5.2 years. The mean preoperative PSA was 11.9 ± 7.3 ng/ml (1.9-31), and 29 patients (46%) had a PSA > 10 ng/ml. The biopsy Gleason score was ≤ 7 for 49 patients (76.6%). After pathologic analysis, there were 25 (39%) stage pT2, 37 (58%) stage pT3, and 2 (3%) stage pT4 patients. Nine patients had lymph node involvement (14%). The surgical margins were positive in 25 patients (39%). In 51 patients, (80%) the Gleason score was underestimated by biopsies: 40 patients with a definitive score of Gleason 8 had a Gleason score of 6 or 7 on biopsies, while 11 patients with a Gleason score of 9 initially, had a Gleason score of 7 or 8. Twenty-seven patients underwent adjuvant treatment: external radiation therapy (n = 19), HRT (n = 3), or both (n = 5). During follow-up, 41 patients (64%) presented with a biochemical recurrence, and 11 (17%) died. The PSA-free survival rate at five year was 44%. RP remains a possible therapeutic option in certain cases of the high-risk cohort of patients with a Gleason score ≥ 8. However, patients should be warned that surgery might only be the first step of a multi-modal treatment approach. The modalities of adjuvant treatments and the right schedule to deliver it following RP still need to be defined. Copyright © 2011 Elsevier Inc. All rights reserved.

  9. Roy's safety-first portfolio principle in financial risk management of disastrous events.

    Science.gov (United States)

    Chiu, Mei Choi; Wong, Hoi Ying; Li, Duan

    2012-11-01

    Roy pioneers the concept and practice of risk management of disastrous events via his safety-first principle for portfolio selection. More specifically, his safety-first principle advocates an optimal portfolio strategy generated from minimizing the disaster probability, while subject to the budget constraint and the mean constraint that the expected final wealth is not less than a preselected disaster level. This article studies the dynamic safety-first principle in continuous time and its application in asset and liability management. We reveal that the distortion resulting from dropping the mean constraint, as a common practice to approximate the original Roy's setting, either leads to a trivial case or changes the problem nature completely to a target-reaching problem, which produces a highly leveraged trading strategy. Recognizing the ill-posed nature of the corresponding Lagrangian method when retaining the mean constraint, we invoke a wisdom observed from a limited funding-level regulation of pension funds and modify the original safety-first formulation accordingly by imposing an upper bound on the funding level. This model revision enables us to solve completely the safety-first asset-liability problem by a martingale approach and to derive an optimal policy that follows faithfully the spirit of the safety-first principle and demonstrates a prominent nature of fighting for the best and preventing disaster from happening. © 2012 Society for Risk Analysis.

  10. CERN Library | Roy Calne presents: "The Ratchet of Science - Curiosity killed the cat" | 26 October

    CERN Multimedia

    CERN Library

    2015-01-01

    Sir Roy Calne will discuss his most recent book: “The Ratchet of Science - Curiosity killed the cat. Can human nature cope with the rapid and accelerated advances of science?”   Monday, 26 October - 4.30 p.m. CERN Filtration plant, Room 222-R-001 There is a limited number of seats. Please register here. The book’s premise is that huge scientific advances throughout history occur in spurts or “ratchets”. It reflects on the good and the evil consequences of discoveries. Due to the worrying nature of human beings, each ratchet in our knowledge is too often accompanied by dangerous applications. Knowledge, once established by a reliable scientific method, cannot be unlearned. The cat is out of the bag and the curiosity may kill the cat – so to speak. Professor Roy Calne illustrates this with the example of the young physicist known to all at CERN: Lise Meitner, who discovered and named nucle...

  11. [People with venous ulcers: a study of the psychosocial aspects of the Roy Adaptation Model].

    Science.gov (United States)

    Costa, Isabelle Katherinne Fernandes; da Nóbrega, Walkíria Gomes; Costa, Isabel Karolyne Fernandes; Torres, Gilson de Vasconcelos; Lira, Ana Luiza Brandão de Carvalho; Tourinho, Francis Solange Vieira; Enders, Bertha Cruz

    2011-09-01

    A transversal descriptive quantitative study, conducted with 50 people with Venous Ulcer (VU) at an University Hospital, that aimed to ascertain the level of psychosocial adaptation of the Roy Model of people with VU. The study was approved by the Ethics Committee. The data were collected with a structured form. After organizing the data, composed of changes in the lives of people with VU, we classified it according to Roy's psychosocial aspects. We found that in the self-concept mode, 36% felt dissatisfied with physical appearance, and 18% had negative feelings; in the role-function mode: change in the working role (52.0%), housework (34.0%), marital (6.0%), leisure, pain, social, educational and transportation restrictions (82.0%); interdependence mode: support in treatment (82.0%), discrimination (58.0%). The identification of the psychosocial aspects directs nursing actions to consider the whole of the person receiving care in its relations with the environment, thus promoting a better level of adaptation.

  12. DIAGNÓSTICOS DE ENFERMAGEM E MODELO TÉORICO DE ROY EM PACIENTES PROSTATECTOMIZADOS

    Directory of Open Access Journals (Sweden)

    Elisandra de Araújo Saldanha

    2013-01-01

    Full Text Available Estudio descriptivo, con objetivo de identificar el perfil de los diagnósticos de enfermería internacional NANDA en pacientes en postoperatorio inmediato de prostatectomía y relacionarlos con los problemas de adaptación del Modelo de Adaptación de Roy. Llevado a cabo en hospital universitario en Nordeste de Brasil, entre noviembre/2010 y abril/2011, con muestra de 50 individuos. Los datos fueron recolectados a través de entrevista y examen físico, con posterior análisis por medio del razonamiento clínico. Fueron encontrados las relaciones: riesgo de caídas y posibles lesiones; alteración de la deambulación y la movilidad a pie y/o coordinación restringida; déficits de autocuidado y pérdida de la capacidad de autocuidado; dolor agudo y dolor agudo; patrones de insomnio/sueño y privación del sueño con discapacidad; estreñimiento y estreñimiento. Por lo tanto, la mayor parte de los diagnósticos de enfermería identificados son similares a los problemas de adaptación de acuerdo con Roy.

  13. PLURALISM, FATWA, AND COURT IN INDONESIA: The Case of Yusman Roy

    Directory of Open Access Journals (Sweden)

    Nadirsyah Hosen

    2012-06-01

    Full Text Available The interrelation between Islam, state and pluralism is an unfinished discussion in Indonesia. This paper examines an issue of promoting individual freedom to practice his/her belief, and at the same time not insulting the majority belief in a plural society. It takes the case of Yusman Roy on performing the salah (prayer in a local language as the subject of analysis in order to identify the fault lines of religion and pluralism, and to consider how best to address them. The paper argues that fatwa and court should not be used as mechanisms to deal with the issue of religion and pluralism. It further argues for an “alternative dispute resolution” in dealing with the plurality of interpretation within Islamic tradition and at the same time maintaining the unity and harmony Islamic communities. It maintains that Roy should have the rights to practice what he believes, but at the same time, a negotiation on how he spreads his ideas outside his schools should take place in order to avoid provocative actions that invite violence.

  14. Estudio de la evidencia del concepto de grupo en el modelo de adaptación de Roy

    OpenAIRE

    Cavalcante Guedes, María Vilaní; Lopes, Marcos Venícios de Oliveira; Araujo, Thelma Leite de

    2005-01-01

    El estudio tiene como objetivo evaluar el concepto de grupo en el Modelo de Adaptación de Roy tomando por parámetro el criterio interno de evidencia del modelo de análisis de teoría propuesto por Barnum (1998). Discutimos el concepto de grupo con base en diferentes autores, y también según descrito por Roy en sus diversos modos de adaptación. Encontramos que la evidencia del concepto grupo, en los modos de adaptación, se quedó perjudicada y que el Modelo Teórico ...

  15. A comparative analysis of primary and secondary Gleason pattern predictive ability for positive surgical margins after radical prostatectomy.

    Science.gov (United States)

    Sfoungaristos, S; Kavouras, A; Kanatas, P; Polimeros, N; Perimenis, P

    2011-01-01

    To compare the predictive ability of primary and secondary Gleason pattern for positive surgical margins in patients with clinically localized prostate cancer and a preoperative Gleason score ≤ 6. A retrospective analysis of the medical records of patients undergone a radical prostatectomy between January 2005 and October 2010 was conducted. Patients' age, prostate volume, preoperative PSA, biopsy Gleason score, the 1st and 2nd Gleason pattern were entered a univariate and multivariate analysis. The 1st and 2nd pattern were tested for their ability to predict positive surgical margins using receiver operating characteristic curves. Positive surgical margins were noticed in 56 cases (38.1%) out of 147 studied patients. The 2nd pattern was significantly greater in those with positive surgical margins while the 1st pattern was not significantly different between the 2 groups of patients. ROC analysis revealed that area under the curve was 0.53 (p=0.538) for the 1st pattern and 0.60 (p=0.048) for the 2nd pattern. Concerning the cases with PSA <10 ng/ml, it was also found that only the 2nd pattern had a predictive ability (p=0.050). When multiple logistic regression analysis was conducted it was found that the 2nd pattern was the only independent predictor. The second Gleason pattern was found to be of higher value than the 1st one for the prediction of positive surgical margins in patients with preoperative Gleason score ≤ 6 and this should be considered especially when a neurovascular bundle sparing radical prostatectomy is planned, in order not to harm the oncological outcome.

  16. The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System.

    Science.gov (United States)

    Epstein, Jonathan I; Egevad, Lars; Amin, Mahul B; Delahunt, Brett; Srigley, John R; Humphrey, Peter A

    2016-02-01

    In November, 2014, 65 prostate cancer pathology experts, along with 17 clinicians including urologists, radiation oncologists, and medical oncologists from 19 different countries gathered in a consensus conference to update the grading of prostate cancer, last revised in 2005. The major conclusions were: (1) Cribriform glands should be assigned a Gleason pattern 4, regardless of morphology; (2) Glomeruloid glands should be assigned a Gleason pattern 4, regardless of morphology; (3) Grading of mucinous carcinoma of the prostate should be based on its underlying growth pattern rather than grading them all as pattern 4; and (4) Intraductal carcinoma of the prostate without invasive carcinoma should not be assigned a Gleason grade and a comment as to its invariable association with aggressive prostate cancer should be made. Regarding morphologies of Gleason patterns, there was clear consensus on: (1) Gleason pattern 4 includes cribriform, fused, and poorly formed glands; (2) The term hypernephromatoid cancer should not be used; (3) For a diagnosis of Gleason pattern 4, it needs to be seen at 10x lens magnification; (4) Occasional/seemingly poorly formed or fused glands between well-formed glands is insufficient for a diagnosis of pattern 4; (5) In cases with borderline morphology between Gleason pattern 3 and pattern 4 and crush artifacts, the lower grade should be favored; (6) Branched glands are allowed in Gleason pattern 3; (7) Small solid cylinders represent Gleason pattern 5; (8) Solid medium to large nests with rosette-like spaces should be considered to represent Gleason pattern 5; and (9) Presence of unequivocal comedonecrosis, even if focal is indicative of Gleason pattern 5. It was recognized by both pathologists and clinicians that despite the above changes, there were deficiencies with the Gleason system. The Gleason grading system ranges from 2 to 10, yet 6 is the lowest score currently assigned. When patients are told that they have a Gleason score 6 out

  17. A new analysis of π K scattering from Roy and Steiner type equations

    International Nuclear Information System (INIS)

    Buettiker, P.; Descotes-Genon, S.; Moussallam, B.

    2004-01-01

    With the aim of generating new constraints on the OZI suppressed couplings of chiral perturbation theory a set of six equations of the Roy and Steiner type for the S- and P-waves of the πK scattering amplitudes is derived. The range of validity and the multiplicity of the solutions are discussed. Precise numerical solutions are obtained in the range E or sim 1 GeV for both πK→πK and ππ→ KK amplitudes. Our main result is the determination of a narrow allowed region for the two S-wave scattering lengths. Present experimental data below 1 GeV are found to be in generally poor agreement with our results. A set of threshold expansion parameters, as well as sub-threshold parameters are computed. For the latter, a matching with the SU(3) chiral expansion at NLO is performed. (orig.)

  18. High-Precision Determination of the Pion-Nucleon σ Term from Roy-Steiner Equations

    Science.gov (United States)

    Hoferichter, Martin; Ruiz de Elvira, Jacobo; Kubis, Bastian; Meißner, Ulf-G.

    2015-08-01

    We present a determination of the pion-nucleon (π N ) σ term σπ N based on the Cheng-Dashen low-energy theorem (LET), taking advantage of the recent high-precision data from pionic atoms to pin down the π N scattering lengths as well as of constraints from analyticity, unitarity, and crossing symmetry in the form of Roy-Steiner equations to perform the extrapolation to the Cheng-Dashen point in a reliable manner. With isospin-violating corrections included both in the scattering lengths and the LET, we obtain σπ N=(59.1 ±1.9 ±3.0 ) MeV =(59.1 ±3.5 ) MeV , where the first error refers to uncertainties in the π N amplitude and the second to the LET. Consequences for the scalar nucleon couplings relevant for the direct detection of dark matter are discussed.

  19. Matching Pion-Nucleon Roy-Steiner Equations to Chiral Perturbation Theory

    Science.gov (United States)

    Hoferichter, Martin; Ruiz de Elvira, Jacobo; Kubis, Bastian; Meißner, Ulf-G.

    2015-11-01

    We match the results for the subthreshold parameters of pion-nucleon scattering obtained from a solution of Roy-Steiner equations to chiral perturbation theory up to next-to-next-to-next-to-leading order, to extract the pertinent low-energy constants including a comprehensive analysis of systematic uncertainties and correlations. We study the convergence of the chiral series by investigating the chiral expansion of threshold parameters up to the same order and discuss the role of the Δ (1232 ) resonance in this context. Results for the low-energy constants are also presented in the counting scheme usually applied in chiral nuclear effective field theory, where they serve as crucial input to determine the long-range part of the nucleon-nucleon potential as well as three-nucleon forces.

  20. Pion-nucleon scattering: from chiral perturbation theory to Roy-Steiner equations

    Science.gov (United States)

    Kubis, Bastian; Hoferichter, Martin; de Elvira, Jacobo Ruiz; Meißner, Ulf-G.

    2016-11-01

    Ever since Weinberg's seminal predictions of the pion-nucleon scattering amplitudes at threshold, this process has been of central interest for the study of chiral dynamics involving nucleons. The scattering lengths or the pion-nucleon σ-term are fundamental quantities characterizing the explicit breaking of chiral symmetry by means of the light quark masses. On the other hand, pion-nucleon dynamics also strongly affects the long-range part of nucleon-nucleon potentials, and hence has a far-reaching impact on nuclear physics. We discuss the fruitful combination of dispersion-theoretical methods, in the form of Roy-Steiner equations, with chiral dynamics to determine pion-nucleon scattering amplitudes at low energies with high precision.*

  1. Contraste de un modelo de envejecimiento exitoso derivado del modelo de Roy

    Directory of Open Access Journals (Sweden)

    María Amparo Kantún Marín

    2017-01-01

    Full Text Available Se formula y contrasta un modelo de envejecimiento exitoso derivado del modelo de adaptación de Roy. Se analizó una muestra no probabilística de 255 adultos mayores de seis centros sociales y un centro médico de consulta externa en Nuevo León, México. Se usó un modelamiento de ecuaciones estructurales. En el modelo final los estímulos focales de autopercepción del envejecimiento, entorno peatonal inmediato y el estímulo contextual de síntomas depresivos incidieron sobre el afrontamiento, que a su vez predijo el envejecimiento exitoso. El modelo tuvo buen ajuste al añadirse dos correlaciones entre residuos de medida de afrontamiento y envejecimiento exitoso. Los resultados obtenidos sugieren que el afrontamiento es un indicador directo del envejecimiento activo.

  2. Type of Diabetes Mellitus and the Odds of Gleason Score 8 to 10 Prostate Cancer

    International Nuclear Information System (INIS)

    Kang, Josephine; Chen Minghui; Zhang Yuanye; Moran, Brian J.; Dosoretz, Daniel E.; Katin, Michael J.; Braccioforte, Michelle H.; Salenius, Sharon A.; D'Amico, Anthony V.

    2012-01-01

    Purpose: It has been recently shown that diabetes mellitus (DM) is significantly associated with the likelihood of presenting with high-grade prostate cancer (PCa) or Gleason score (GS) 8 to 10; however, whether this association holds for both Type 1 and 2 DM is unknown. In this study we evaluated whether DM Type 1, 2, or both are associated with high-grade PCa after adjusting for known predictors of high-grade disease. Methods and Materials: Between 1991 and 2010, a total of 15,330 men diagnosed with PCa and treated with radiation therapy were analyzed. A polychotomous logistic regression analysis was performed to evaluate whether Type 1 or 2 DM was associated with odds of GS 7 or GS 8 to 10 compared with 6 or lower PCa, adjusting for African American race, age, prostate-specific antigen (PSA) level, and digital rectal examination findings. Results: Men with Type 1 DM (adjusted odds ratio [AOR], 2.05; 95% confidence interval [CI], 1.28–3.27; p = 0.003) or Type 2 DM (AOR, 1.58; 95% CI, 1.26–1.99; p < 0.001) were significantly more likely to be diagnosed with GS 8 to 10 PCa compared with nondiabetic men. However this was not true for GS 7, for which these respective results were AOR, 1.30; 95% CI, 0.93–1.82; p = 0.12 and AOR, 1.13; 95% CI, 0.98–1.32; p = 0.10. Conclusion: Type 1 and 2 DM were associated with a higher odds of being diagnosed with Gleason score 8 to 10 but not 7 PCa. Pending validation, men who are diagnosed with Type I DM with GS 7 or lower should be considered for additional workup to rule out occult high-grade disease.

  3. Gleason grading challenges in the diagnosis of prostate adenocarcinoma: experience of a single institution.

    Science.gov (United States)

    Chen, Sonja D; Fava, Joseph L; Amin, Ali

    2016-02-01

    Gleason score (GS) is an important factor in determining management and outcome of prostate adenocarcinoma. A standard GS scheme was introduced by ISUP 2005 consensus conference, but there is still significant discordance in grading prostate adenocarcinomas among pathologists, especially between genitourinary-trained (GU) and non-GU pathologists. All biopsies from outside institutions referred for definitive treatment in our hospital are reviewed by a GU pathologist for confirmation and quality assurance. From 2011 to 2013, 117 consecutive prostate consults were retrieved and compared with the initial outside reports as well as final radical prostatectomy (RP) results. Follow-up prostate specific antigen (PSA) was assessed pre- and post-RP, and the results were analyzed. The overall initial GS was higher for all specimens (p = 0.007) especially for the RP cases (p = 0.002). Overall, the modal GS on initial diagnosis was GS7(4 + 3) that was downgraded to the modal GS6(3 + 3) upon review. Despite an overall substantial agreement between the non-GU and GU pathologists [ICC = 0.66], GS by GU pathologist had higher correlation with the final GS in the RP specimen [ICC = 0.62] than non-GU pathologist [ICC = 0.48]. GS on all reviewed cases were found to correlate significantly with the pre-operative PSA (p = 0.002) but the same was not true for the initial report. A non-GU pathologist is more likely to assign a higher GS than a GU pathologist, with a trend to overcall Gleason pattern 4. Considering the implications on treatment, close attention must be paid to the ISUP 2005 consensus conference recommendations.

  4. Type of Diabetes Mellitus and the Odds of Gleason Score 8 to 10 Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Josephine, E-mail: jkang3@partners.org [Harvard Radiation Oncology Program, Boston, MA (United States); Chen Minghui; Zhang Yuanye [Department of Statistics, University of Connecticut, Storrs, CT (United States); Moran, Brian J. [Prostate Cancer Foundation of Chicago, Westmont, IL (United States); Dosoretz, Daniel E.; Katin, Michael J. [Department of Radiation Oncology, 21 Century Oncology, Inc., Fort Myers, FL (United States); Braccioforte, Michelle H. [Prostate Cancer Foundation of Chicago, Westmont, IL (United States); Salenius, Sharon A. [Department of Radiation Oncology, 21 Century Oncology, Inc., Fort Myers, FL (United States); D' Amico, Anthony V. [Harvard Radiation Oncology Program, Boston, MA (United States); Department of Radiation Oncology, Brigham and Women' s Hospital and Dana Farber Cancer Institute, Boston, MA (United States)

    2012-03-01

    Purpose: It has been recently shown that diabetes mellitus (DM) is significantly associated with the likelihood of presenting with high-grade prostate cancer (PCa) or Gleason score (GS) 8 to 10; however, whether this association holds for both Type 1 and 2 DM is unknown. In this study we evaluated whether DM Type 1, 2, or both are associated with high-grade PCa after adjusting for known predictors of high-grade disease. Methods and Materials: Between 1991 and 2010, a total of 15,330 men diagnosed with PCa and treated with radiation therapy were analyzed. A polychotomous logistic regression analysis was performed to evaluate whether Type 1 or 2 DM was associated with odds of GS 7 or GS 8 to 10 compared with 6 or lower PCa, adjusting for African American race, age, prostate-specific antigen (PSA) level, and digital rectal examination findings. Results: Men with Type 1 DM (adjusted odds ratio [AOR], 2.05; 95% confidence interval [CI], 1.28-3.27; p = 0.003) or Type 2 DM (AOR, 1.58; 95% CI, 1.26-1.99; p < 0.001) were significantly more likely to be diagnosed with GS 8 to 10 PCa compared with nondiabetic men. However this was not true for GS 7, for which these respective results were AOR, 1.30; 95% CI, 0.93-1.82; p = 0.12 and AOR, 1.13; 95% CI, 0.98-1.32; p = 0.10. Conclusion: Type 1 and 2 DM were associated with a higher odds of being diagnosed with Gleason score 8 to 10 but not 7 PCa. Pending validation, men who are diagnosed with Type I DM with GS 7 or lower should be considered for additional workup to rule out occult high-grade disease.

  5. Significance of periacinar cleftings as supporting criteria in diagnosis of prostatic adenocarcinoma Gleason score-a 7 (3+4 and Gleason score-a 7 (4+3 and their relationship with parameters of predictive value

    Directory of Open Access Journals (Sweden)

    Mijović Milica

    2014-01-01

    Full Text Available Diagnosis of different pathohystological diseases of prostate in the most cases is based on common benignant and malignant characteristics. The presence of periacinar cleftings (PC is an additional criterion favouring prostatic adenocarcinoma. According to the presence and extent of PC, analysed on high power field (400x, glands were classified into 3 groups: group 1-glands without PC or with PC affecting ≤50% of gland circumference; group 2-glands with PC affecting >50% gland circumference in 50% gland circumference in ≥50% examined glands. The aim of our study was to determine the importance of presence of PC in prostatic adenocarcinoma (ADCP of Gleason score 7(3+4 and 7(4+3 and establish the existence of differences in their appearance at ADCP with first and second dominant histological grade 3 and 4 in each different relationship based on correlation analysis of PC and parameters of the predictive value (preoperative value of serum prostate specific antigen, tumor volume, clinical stage and degree of focal neuroendocrine differentiation. The study included 33 ADCP of Gleason score 7, 26 (78.79% ADCP 7(3+4 and 7 (21.21% ADCP 7(4+3. In ADCP Gleason 7(3+4 periacinar cleftings are more common in tumors that are smaller, better differentiated (produce more PSA, which is diagnosed in less advanced clinical stages and showing a less degree of focal neuroendocrine differentiation. In ADCP Gleason 7(4+3 periacinar cleftings are more common in tumors which produce less value of serum PSA (poorly differentiated and in tumors that are diagnosed in advanced clinical stages. Periacinar cleftings are common findings in prostatic adenocarcinoma Gleason score 7(4+3 which are considerd as tumors with worse prognosis. Because of all we can rank PC among the important additional criteria for the diagnosis of adenocarcinoma of the prostate.

  6. Relationship between apparent diffusion coefficients at 3.0-T MR imaging and Gleason grade in peripheral zone prostate cancer

    NARCIS (Netherlands)

    Hambrock, T.; Somford, D.M.; Huisman, H.J.; Oort, I.M. van; Witjes, J.A.; Hulsbergen-van de Kaa, C.A.; Scheenen, T.W.J.; Barentsz, J.O.

    2011-01-01

    PURPOSE: To retrospectively determine the relationship between apparent diffusion coefficients (ADCs) obtained with 3.0-T diffusion-weighted (DW) magnetic resonance (MR) imaging and Gleason grades in peripheral zone prostate cancer. MATERIALS AND METHODS: The requirement to obtain institutional

  7. Immunogold electron microscopic localization of timothy grass (Phleum pratense) pollen major allergens Phl p I and Phl p V after anhydrous fixation in acrolein vapor

    NARCIS (Netherlands)

    Grote, M.; Dolecek, C.; van Ree, R.; Valenta, R.

    1994-01-01

    We used the vapor phase of acrolein as an anhydrous fixative for timothy grass pollen in an immunogold double-labeling localization study of two different major allergens, Phl p I and Phl p V. More than 48 hr of fixation were needed for the subcellular pollen structures to be satisfactorily

  8. Group 5 allergens of timothy grass (Phl p 5) bear cross-reacting T cell epitopes with group 1 allergens of rye grass (Lol p 1).

    Science.gov (United States)

    Müller, W D; Karamfilov, T; Bufe, A; Fahlbush, B; Wolf, I; Jäger, L

    1996-04-01

    Selected human T cell clones reactive with group 5 allergens of timothy grass (Phl p 5) were cross-stimulated in specific proliferation assays with group 1 allergens of rye grass (Lol p 1). Such interspecies cross-reactivities result obviously from structural motifs presented on defined Phl p 5 fragments as shown with recombinant Phl p 5 products.

  9. O padrão 4 de Gleason e o volume tumoral no prognóstico do carcinoma da próstata Well differentiated localized prostate carcinoma: prognostic relevance of tertiary Gleason pattern 4 and tumor volume

    Directory of Open Access Journals (Sweden)

    Katia R. M. Leite

    2005-12-01

    Full Text Available OBJETIVOS: A introdução de terapia adjuvante pós-prostatectomia radical foi recentemente proposta na literatura na tentativa de se obter melhores taxas de sobrevida em pacientes com câncer de próstata com maior risco de recidiva da doença. Alguns parâmetros anatomopatológicos têm sido considerados bons determinantes dos riscos de recorrência local ou à distância desses tumores. Recentemente o volume tumoral e a presença de padrão terciário de Gleason menos diferenciado foram apresentados como os melhores indicadores do comportamento do carcinoma da próstata. A proposta deste estudo é avaliar a importância da presença e porcentagem do padrão 4 de Gleason e do volume tumoral na evolução de pacientes portadores da adenocarcinoma bem diferenciado de próstata, tratados com prostatectomia radical. MÉTODOS: Setenta e sete pacientes portadores de adenocarcinoma bem diferenciado da próstata, Gleason 6 ou menos, submetidos a prostatectomia radical entre 1995 e 1997 foram estudados. Trinta e sete pacientes sofreram recidiva bioquímica (PSA > 0,4 ng/ml, e 40 pacientes permaneceram livres de doença após seguimento mínimo de cinco anos. A presença e porcentagem do padrão 4 de Gleason, a porcentagem de tumor comprometendo a glândula (considerado como "volume tumoral", a infiltração capsular e a invasão do tecido extraprostático foram submetidos a análise uni e multivariada para determinação da associação destes parâmetros com a recidiva bioquímica. RESULTADOS: O volume tumoral foi o parâmetro mais importante para determinação da recorrência bioquímica em análises uni e multivariadas. A mediana do volume foi de 25% nos pacientes que sofreram recidiva e 11,5% naqueles que permaneceram livres de doença (p=0,003. A porcentagem de padrão 4 de Gleason foi importante apenas em análise univariada. A mediana da porcentagem de Gleason 4 foi de 7,5% para os pacientes que não sofreram recidiva e de 19% naqueles que

  10. Clinical role of pathological downgrading after radical prostatectomy in patients with biopsy-proven Gleason score 3+4 prostate cancer

    Science.gov (United States)

    Gondo, Tatsuo; Poon, Bing Ying; Matsumoto, Kazuhiro; Bernstein, Melanie; Sjoberg, Daniel D.; Eastham, James A.

    2014-01-01

    Objective To identify preoperative factors predicting Gleason score downgrading after radical prostatectomy in patients with biopsy Gleason score 3+4 prostate cancer. To determine if prediction of downgrading can identify potential candidates for active surveillance. Patients and Methods We identified 1317 patients with biopsy Gleason score 3+4 prostate cancer who underwent radical prostatectomy at Memorial Sloan-Kettering Cancer Center between 2005 and 2013. Several preoperative and biopsy characteristics were evaluated by forward selection regression, and selected predictors of downgrading were analyzed by multivariable logistic regression. Decision curve analysis was performed to evaluate the clinical utility of the multivariate model. Results Gleason score was downgraded after radical prostatectomy in 115 patients (9%). We developed a multivariable model using age, prostate specific antigen density, percent of positive cores with Gleason 4 cancer out of all cores taken, and maximum percent of cancer involvement within a positive core with Gleason 4 cancer. The area under the curve for this model was 0.75 after ten-fold cross validation. However, decision curve analysis revealed that the model was not clinically helpful in identifying patients who will downgrade at radical prostatectomy for the purpose of reassigning them to active surveillance. Conclusion While patients with pathology Gleason score 3+3 with tertiary Gleason pattern 4 or lower at radical prostatectomy in patients with biopsy Gleason score 3+4 prostate cancer may be potential candidates for active surveillance, decision curve analysis showed limited utility of our model to identify such men. Future study is needed to identify new predictors to help identify potential candidates for active surveillance among patients with biopsy-proven Gleason score 3+4 prostate cancer. PMID:24725760

  11. Safety of sublingual immunotherapy Timothy grass tablet in subjects with allergic rhinitis with or without conjunctivitis and history of asthma

    DEFF Research Database (Denmark)

    Maloney, J; Durham, S; Skoner, D

    2015-01-01

    BACKGROUND: Patients with asthma may be more susceptible to adverse events (AEs) with sublingual immunotherapy tablet (SLIT-tablet) treatment, such as severe systemic reactions and asthma-related events. Using data from eight trials of grass SLIT-tablet in subjects with allergic rhinitis with....../without conjunctivitis (AR/C), AE frequencies were determined in adults and children with and without reported asthma. METHODS: Data from randomized, double-blind, placebo-controlled trials of Timothy grass SLIT-tablet MK-7243 (2800 BAU/75 000 SQ-T, Merck/ALK-Abelló) were pooled for post hoc analyses. Subjects...... with asthma treated with grass SLIT-tablet versus subjects without asthma in or outside of pollen season. There were 6/120 asthma-related TRAEs assessed as severe with grass SLIT-tablet and 2/60 with placebo, without a consistent trend among subjects with and without asthma (5 and 3 events, respectively...

  12. Sequential Treatment Initiation with Timothy Grass and Ragweed Sublingual Immunotherapy Tablets Followed by Simultaneous Treatment Is Well Tolerated.

    Science.gov (United States)

    Maloney, Jennifer; Berman, Gary; Gagnon, Remi; Bernstein, David I; Nelson, Harold S; Kleine-Tebbe, Jörg; Kaur, Amarjot; Li, Qing; Nolte, Hendrik

    2016-01-01

    Dual treatment with grass and ragweed sublingual immunotherapy (SLIT) tablets has not been studied. To characterize the safety and tolerability of dual grass and ragweed SLIT-tablet administration. This open-label, multicenter trial (NCT02256553) enrolled North American adults (N = 102) allergic to grass and ragweed. The trial had 3 periods, each of 2 weeks duration. In period 1, subjects received once-daily timothy grass SLIT tablet (2800 bioequivalent allergen unit; Merck, Inc, Kenilworth, NJ/ALK, Hørsholm, Denmark). In period 2, subjects received a short ragweed SLIT tablet (12 Ambrosia artemisiifolia 1-U; Merck/ALK) every morning and a grass SLIT tablet every evening. In period 3, subjects received once-daily grass and ragweed SLIT tablets within 5 minutes (simultaneous intake). The primary end point was the proportion of subjects with 1 or more local swelling events in each period. Secondary end points were the proportion of subjects with 1 or more local adverse events (AEs), that discontinued the treatment because of AEs, and subjects with 1 or more local AEs requiring treatment. No severe swellings, systemic allergic reactions, asthma attacks, or reactions requiring epinephrine were reported. Most (99%) AEs were graded mild to moderate. The proportions of subjects with 1 or more local swelling events were 14%, 22%, and 15% for periods 1, 2, and 3, respectively. For periods 1, 2, and 3, the proportions of subjects with 1 or more local AEs were 71%, 69%, and 56%, respectively; the proportions discontinuing the treatment because of treatment-related AEs were 5%, 1%, and 2%, and the proportions with 1 or more local AEs requiring treatment were 4%, 4%, and 1%. In this trial, a 4-week sequential SLIT-tablet dosing schedule followed by simultaneous intake of timothy grass and ragweed tablets was well tolerated. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  13. The bacterial population adherent to plant particles in the rumen of reindeer fed lichen, timothy hay or silage

    Directory of Open Access Journals (Sweden)

    Monica Alterskjær Olsen

    1998-02-01

    Full Text Available Male reindeer (Rangifer tarandus tarandus calves taken from a natural winter pasture were given ad lib. access to lichen (n = 3, timothy silage (n = 3 and hay (n = 3 for 7 weeks. Median numbers of viable anaerobic bacteria adherent to the plant particles (cells/g wet weight of rumen solids, growing on a habitat simulating medium (M8V, were significantly higher (P = 0.05 in the rumen of reindeer fed lichen (26.5 x 109- 53.0 x 109 and hay (4.0 x 109- 40.5 x 109, compared to reindeer fed silage (1.15 x 109 - 3.25 x 109. Anaerobic bacterial strains (n = 551 from the plant particles obtained from the rumen of the nine reindeer examined, were isolated using an acid swollen cellulose medium (M8SC and tested for their ability to hydrolyse carboxymethyl cellulose (CMC. The proportion of CMC hydrolysing adherent bacteria isolated from M8SC was significantly higher in reindeer fed hay (21.5% compared ro animals fed lichen (5.3% and silage (2.7% (P = 0.05. The CMC hydrolysing bacterial srrains (n=42 isolated from reindeer fed hay where characterised as non-cellulolytic Butyrivibrio fibrisolvens (9.5%, cellulolytic B. fibrisolvens (50.0%, Clostridium sp. (2.4% and unknowns (38.1%, while CMC hydrolysing strains (n=11 isolated from animals fed lichen and strains (n=4 isolated from animals fed silage where all characterised as B. fibrisolvens. None of the bacterial strains isolated from the rumen solids of reindeer fed lichen or silage were found to be cellulolytic. This study suggests that both lichen and timothy silage have a negative influence, compared to hay, on the numbers of cellulolytic bacteria adherent to the plant particles in the rumen of reindeer.

  14. Historical evolution of the concept environment proposed in the Roy adaptation model Evolución histórica del concepto entorno propuesto en el modelo de la adaptación de Roy Evolução histórica do conceito ambiente proposto no modelo da adaptação de Roy

    Directory of Open Access Journals (Sweden)

    Marcos Venícios de Oliveira Lopes

    2006-04-01

    Full Text Available The concern for the development of concepts becomes even more important when we report to its use in Nursing theories, in which some concepts are considered central, such as person, environment, health and nursing. This study aims to discuss the historical evolution of the environment concept used in the Roy Adaptation Model. The method of analysis the study was based on is the evolutionary conceptual analysis of the concept Environment of the Roy Adaptation Model. According to the research results, Environment is introduced as the second major concept in the Roy Adaptation Model. In this theorist's interpretation of the environment, we notice her interest in surpassing the mechanistic point of view upon which the first version of the model was based. The approach of the concept of interaction between people and groups seems to represent an improvement, influenced by the current thoughts that are preeminent in nursing.La preocupación con el desarrollo de conceptos se vuelve más importante cuando nos reportamos para su uso en teorías de Enfermería. En ellas, algunos conceptos son considerados centrales, tales como persona, ambiente, salud y enfermería. Este artículo visa examinar la evolución histórica del concepto de ambiente utilizado en el Modelo de Adaptación de Roy. El método de análisis en que el estudio fue basado es el análisis conceptual evolucionario del concepto Ambiente del Modelo de Adaptación de Roy. De acuerdo con los resultados del estudio, Ambiente es introducido como el segundo concepto más importante en el Modelo de Adaptación de Roy. En la interpretación que la teórica hace del ambiente, notamos su interés en ultrapasar el punto de vista mecanicista en que la primera versión del modelo era basada. La propuesta de interacción del concepto ambiente con personas y grupos parece representar una mejoría, influenciada por los pensamientos corrientes que son predominantes en la enfermería.A preocupação com o

  15. Da pesquisa à prática de enfermagem aplicando o modelo de adaptação de Roy De la investigación a la práctica de enfermería mediante la aplicación del modelo de adaptación de Roy From research to nursing practice applying the Roy adaptation model

    Directory of Open Access Journals (Sweden)

    Sónia Margarida Santos Coelho

    2011-12-01

    Full Text Available Os modelos e as teorias de enfermagem contribuem para o desenvolvimento do conhecimento em enfermagem, guiando as investigações no sentido do desenvolvimento da disciplina e, consequentemente, da prática. De acordo como o Modelo de Adaptação de Roy, a pessoa é vista como um ser adaptável com mecanismos que permitem a adaptação de comportamentos em resposta aos estímulos ambientais. De fato, a pessoa é o enfoque central dos cuidados de enfermagem, visando-se sempre a melhoria dos cuidados prestados baseados em investigação. A metodologia do Modelo de Adaptação de Roy baseia-se na aplicabilidade do processo de enfermagem, facilitando aos enfermeiros a coleta de dados, estabelecimento de objetivos e diagnósticos de enfermagem, a determinação de intervenções de enfermagem e a posterior avaliação do processo. Assim o objetivo desta pesquisa é realizar uma revisão crítica da aplicação do Modelo Adaptação de Roy aplicado à prática e à pesquisa em Enfermagem.Los modelos y teorías de enfermería contribuyen para el desarrollo del conocimiento en Enfermería, guiando las investigaciones para el desarrollo de la disciplina y, consecuentemente, de la práctica. De acuerdo con el Modelo de Adaptación de Roy se ve la persona como un mecanismo de adaptación que permite el ajuste del comportamiento en respuesta a estímulos ambientales. De hecho, la persona es el foco central de la atención de enfermería, buscando siempre el mejoramiento de la atención basada en la investigación. La metodología del Modelo de Adaptación de Roy se basa en la aplicación del proceso de enfermería, lo que facilita a las enfermeras para recopilar datos, establecer metas y diagnósticos de enfermería, la determinación de las intervenciones de enfermería y el proceso de evaluación posterior. Así, el objetivo de esta investigación es una revisión crítica de la aplicación del Modelo de Adaptación de Roy empleado para la práctica y la

  16. H. A. Gleason's 'individualistic concept' and theory of animal communities: a continuing controversy.

    Science.gov (United States)

    McIntosh, R P

    1995-05-01

    A tradition of natural history and of the lore of early twentieth-century ecology was that organisms lived together and interacted to form natural entities or communities. Before there was a recognizable science of ecology, Mobius (1877) had provided a name 'biocoenosis' for such entities. This concept persisted in the early decades of ecological science; at an extreme it was maintained that the community had integrating capabilities and organization like those of an individual organism, hence the term organismic community. In the 1950s-1970s an alternative individualist concept, derived from the ideas of H. A. Gleason (1939), gained credence which held that communities were largely a coincidence of individualistic species characteristics, continuously varying environments and different probabilities of a species arriving on a given site. During the same period, however, a body of population based theory of animal communities became dominant which perpetuated the idea of patterns in nature based on biotic interactions among species resulting in integrated communities. This theory introduced an extended terminology and mathematical models to explain the organization of species into groups of compatible species governed by rules. In the late 1970s the premises and methods of the theory came under attack and a vigorous debate ensued. The alternatives proposed were, at an extreme, null models of random aggregations of species or stochastic, individualistic aggregations of species, sensu Gleason. Extended research and debate ensued during the 1980s resulting in an explosion of studies of animal communities and a plethora of symposia and volumes of collected works concerning the nature of animal communities. The inherent complexity of communities and the traditional differences among animal ecologists about how they should be defined and delimited, at what scale of taxa, space and time to study them, and appropriate methods of study and analysis have resulted in extended

  17. Writing the Past: Le Roy Ladurie and the Voice of the New History

    Directory of Open Access Journals (Sweden)

    Philippe Carrard

    1985-09-01

    Full Text Available Just as in fiction, discursive strategies in history can reveal the very nature of a project. The positivist historiography that prevailed in the late 19th and early 20th centuries regarded historical facts as givens. Accordingly, it held as its ideal of writing the objective text, that is. the text from which the historian's mediation would be carefully erased. The New History, on the other hand, considers all research to be grounded in a researcher and seeks to indicate by various means that the text does not generate itself. In Carnival in Romans , for example, Le Roy Ladurie explicitly resorts to various facets of the "I": that of the histor , going about the job of uncovering the evidence: that of the commentator, providing historical parallels and explanations; and even that of the emotional self (Barthes' personne passionnelle , making judgments on events and people in the narrative. These changes in writing conventions point to the emergence of a new historical paradigm. At the same time, they overturn the view of the historical text as a non-problematic vehicle for reporting "reality": this text, for the New Historians, becomes a construct, and is presented as such.

  18. Statement of Roy F. Pruett, Mayor, City of Oak Ridge, TN

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    Thank you very much, Mr. Chairman, and Members of the Committee. My name is Roy Pruett, mayor of the city of Oak Ridge, TN, and an executive committee member on the Clinch River MRS task force. It is my pleasure to be here today to testify before this distinguished Committee and present the findings of the Clinch River task force as they relate to subtitle C of the Nuclear Waste Policy Act of 1982, and to the Department of Energy proposal on the Monitored Retrievable Storage facility, the MRS. I represent the city of Oak Ridge, which has been selected for the primary and the first alternative for the siting of an integrated MRS facility for the preparation and packaging of high-level nuclear waste and spent reactor fuel. Of civic and governmental leaders, we concluded that an MRS could safely be built and operated in Oak Ridge. We further concluded, however, that the facility would not be generally perceived as being safe unless the recommendations of the task force were adopted to address concerns and help mitigate impact. Indeed the MRS would not be viewed as a net economic benefit to the site's community, the region, or the State of Tennessee without such appropriate conditions

  19. Roy-Steiner equations for γγ→ππ

    International Nuclear Information System (INIS)

    Hoferichter, Martin; Phillips, Daniel R.; Schat, Carlos

    2011-01-01

    Starting from hyperbolic dispersion relations, we derive a system of Roy-Steiner equations for pion Compton scattering that respects analyticity, unitarity, gauge invariance, and crossing symmetry. It thus maintains all symmetries of the underlying quantum field theory. To suppress the dependence of observables on high-energy input, we also consider once- and twice-subtracted versions of the equations, and identify the subtraction constants with dipole and quadrupole pion polarizabilities. Based on the assumption of Mandelstam analyticity, we determine the kinematic range in which the equations are valid. As an application, we consider the resolution of the γγ→ππ partial waves by a Muskhelishvili-Omnes representation with finite matching point. We find a sum rule for the isospin-two S-wave, which, together with chiral constraints, produces an improved prediction for the charged-pion quadrupole polarizability (α 2 -β 2 ) π± =(15.3±3.7) x 10 -4 fm 5 . We investigate the prediction of our dispersion relations for the two-photon coupling of the σ-resonance Γ σγγ . The twice-subtracted version predicts a correlation between this width and the isospin-zero pion polarizabilities, which is largely independent of the high-energy input used in the equations. Using this correlation, the chiral perturbation theory results for pion polarizabilities, and our new sum rule, we find Γ σγγ =(1.7 ±0.4) keV. (orig.)

  20. Tertiary Gleason pattern in radical prostatectomy specimens is associated with worse outcomes than the next higher Gleason score group in localized prostate cancer.

    Science.gov (United States)

    Özsoy, Mehmet; D'Andrea, David; Moschini, Marco; Foerster, Beat; Abufaraj, Mohammad; Mathieu, Romain; Briganti, Alberto; Karakiewicz, Pierre I; Roupret, Morgan; Seitz, Christian; Czech, Anna Katarzyna; Susani, Martin; Shariat, Shahrokh F

    2018-04-01

    To assess the predictive value of TGP on biochemical recurrence (BCR) and its association with clinicopathological outcomes in a large, multicenter cohort of patients with localized prostate cancer (PCa) treated with radical prostatectomy (RP). Records of 6,041 patients who were treated with RP between 2000 and 2011 for clinically nonmetastatic PCa were, retrospectively, analyzed from prospectively collected datasets. BCR-free survival rates were assessed using univariable and multivariable cox-regression analyses. Median patient age was 61 years (interquartile range [IQR]: 57-66) with a median preoperative prostrate specific antigen of 6ng/ml (IQR: 4-9). Overall, 28% of patients had Gleason score (GS) 6, 0.3% GS 6 + TGP, 33% GS 7 (3 + 4), 0.2% GS 7 (3 + 4) + TGP, 22% GS 7 (4 + 3), 0.2% GS 7 (4 + 3) + TGP, 0.1% GS 8 and 0.4% GS 9 or 10. Median follow-up was 45 months (IQR: 31-57). Harboring a TGP was associated with higher rates of positive surgical margins, lymphovascular invasion, extraprostatic extension, and seminal vesicle invasion than their counterparts within the same GS group as well as in the next higher GS group (all P ≤ 0.05). At 5 years post-RP, BCR estimates were 5% for patients with GS 6, 13% for patients with GS 6 + TGP, 6% for patients with GS 7 (3 + 4), 22% for patients with GS 7 (3 + 4) + TGP, 16% for patients with GS 7 (4 + 3), 41% for patients with GS 7 (4 + 3) + TGP, 38% for patients with GS 8 (4 + 4) and 46% for patients with GS 9 or 10. Patients harboring a TGP had higher BCR rates than the patients in the next higher GS group: GS 6 + TGP vs. GS 7 (3 + 4), HR = 1.6, P = 0.02 and GS 7 (3 + 4)+TGP vs. GS 7 (4 + 3), HR = 1.4, P = 0.03. Patients with a TGP in the GS 7 (4 + 3) group had comparable BCR rates as patients with GS = 8 (P = 0.4) and GS 9 to 10 (P = 0.2). On multivariable analysis that adjusted for the effects of preoperative prostrate specific antigen, nodal involvement, positive surgical margin, extraprostatic disease (pT3a

  1. Role of endorectal magnetic resonance spectroscopic imaging in two different Gleason scores in prostate cancer.

    Science.gov (United States)

    Nagarajan, Rajakumar; Margolis, Daniel; McClure, Tim; Raman, Steve; Thomas, M Albert

    2011-01-01

    The major goal of the work was to record three-dimensional magnetic resonance spectroscopic imaging (MRSI) and to compare metabolite ratios between different Gleason scores (GS). MRSI localized by endorectal coil-acquired point-resolved spectroscopy was performed in 14 men with prostate cancer of GS 6 (n = 7) and 7 (n = 7) using a 1.5-tesla MRI scanner. The ratio of (choline + creatine)/citrate was increased with an increase of GS, i.e. 0.590 ± 0.171 in the target lesion and 0.321 ± 0.157 in the contralateral region of patients with a GS of 6 as opposed to 1.082 ± 0.432 in the target lesion and 0.360 ± 0.243 in the contralateral region of patients with a GS of 7. Our pilot results demonstrated that MRSI was an additional biochemical tool which is complementary to the current imaging modalities for early diagnosis and therapeutic management of prostate cancer. Copyright © 2011 S. Karger AG, Basel.

  2. Effect of a care plan based on Roy adaptation model biological dimension on stroke patients' physiologic adaptation level.

    Science.gov (United States)

    Alimohammadi, Nasrollah; Maleki, Bibi; Shahriari, Mohsen; Chitsaz, Ahmad

    2015-01-01

    Stroke is a stressful event with several functional, physical, psychological, social, and economic problems that affect individuals' different living balances. With coping strategies, patients try to control these problems and return to their natural life. The aim of this study is to investigate the effect of a care plan based on Roy adaptation model biological dimension on stroke patients' physiologic adaptation level. This study is a clinical trial in which 50 patients, affected by brain stroke and being admitted in the neurology ward of Kashani and Alzahra hospitals, were randomly assigned to control and study groups in Isfahan in 2013. Roy adaptation model care plan was administered in biological dimension in the form of four sessions and phone call follow-ups for 1 month. The forms related to Roy adaptation model were completed before and after intervention in the two groups. Chi-square test and t-test were used to analyze the data through SPSS 18. There was a significant difference in mean score of adaptation in physiological dimension in the study group after intervention (P adaptation in the patients affected by brain stroke in the study and control groups showed a significant increase in physiological dimension in the study group by 47.30 after intervention (P adaptation model biological dimension care plan can result in an increase in adaptation in patients with stroke in physiological dimension. Nurses can use this model for increasing patients' adaptation.

  3. Roy Ellen, Stephen J. Lycett, Sarah E. Johns, eds., 2013, Understanding Cultural Transmission in Anthropology: A Critical Synthesis New York and Oxford: Berghahn Books

    Directory of Open Access Journals (Sweden)

    Clelia Viecelli

    2015-10-01

    Full Text Available recensione: Roy Ellen, Stephen J. Lycett, Sarah E. Johns, eds., 2013, Understanding Cultural Transmission in Anthropology: A Critical Synthesis New York and Oxford: Berghahn Books di Clelia Viecelli

  4. A new set of wavelet- and fractals-based features for Gleason grading of prostate cancer histopathology images

    Science.gov (United States)

    Mosquera Lopez, Clara; Agaian, Sos

    2013-02-01

    Prostate cancer detection and staging is an important step towards patient treatment selection. Advancements in digital pathology allow the application of new quantitative image analysis algorithms for computer-assisted diagnosis (CAD) on digitized histopathology images. In this paper, we introduce a new set of features to automatically grade pathological images using the well-known Gleason grading system. The goal of this study is to classify biopsy images belonging to Gleason patterns 3, 4, and 5 by using a combination of wavelet and fractal features. For image classification we use pairwise coupling Support Vector Machine (SVM) classifiers. The accuracy of the system, which is close to 97%, is estimated through three different cross-validation schemes. The proposed system offers the potential for automating classification of histological images and supporting prostate cancer diagnosis.

  5. Immunohistochemical expression of Ets-related gene-transcriptional factor in adenocarcinoma prostate and its correlation with Gleason score

    Directory of Open Access Journals (Sweden)

    Rahul Mannan

    2016-01-01

    Full Text Available Background: Prostate carcinoma is the second leading cause of cancer-related deaths in males worldwide. The burden is expected to grow 1.7 million new cases and 499,000 new deaths by 2030. In developing countries such as India, prostate carcinoma will show an increase by 140% in the next few years. Although the diagnosis of prostate carcinoma can usually be made on histological features, now a days many immunohistochemical (IHC markers are used to distinguish it from benign mimickers as well as in predicting prognosis and treatment. Out of these markers, Ets-related gene (ERG product is a proto-oncogene which participates in chromosomal translocations and is frequently over expressed in prostate carcinoma which harbors ERG-transmembrane protease, serine 2 fusion. Materials and Methods: Fifty cases of carcinoma prostate diagnosed in needle biopsies and prostatic chips, in the Department of Pathology of a tertiary care teaching hospital in Punjab, India, were included in the present study. The slides were observed under the light microscope, and Gleason scoring was done using the 2005 International Society of Urological Pathology modified Gleason system. IHC study for ERG expression was done on all the cases, for which anti-ERG monoclonal rabbit clone antibody EP111 (Dako, Denmark was used. Lymphocytes and endothelial cells were taken as in built positive controls for staining. The intensity of ERG positivity was scored as no staining (0, weak staining (+1, moderate staining (+2 and intense staining (+3. The H score was then calculated by multiplying the intensity of the stain with the percentage (0-100 of the cells showing that staining intensity. The H-score has a range of 0-300. The relationship between IHC expression and clinico-pathological parameters was compared and analyzed using Chi-square test. P < 0.05 was considered statistically significant. Results: Majority of patients included in the study were in the age group of 61-80 (84% of the

  6. Immunohistochemical expression of Ets-related gene-transcriptional factor in adenocarcinoma prostate and its correlation with Gleason score.

    Science.gov (United States)

    Mannan, Rahul; Bhasin, Tejinder Singh; Manjari, Mridu; Singh, Gagandeep; Bhatia, Puneet Kaur; Sharma, Sonam

    2016-01-01

    Prostate carcinoma is the second leading cause of cancer-related deaths in males worldwide. The burden is expected to grow 1.7 million new cases and 499,000 new deaths by 2030. In developing countries such as India, prostate carcinoma will show an increase by 140% in the next few years. Although the diagnosis of prostate carcinoma can usually be made on histological features, now a days many immunohistochemical (IHC) markers are used to distinguish it from benign mimickers as well as in predicting prognosis and treatment. Out of these markers, Ets-related gene (ERG product) is a proto-oncogene which participates in chromosomal translocations and is frequently over expressed in prostate carcinoma which harbors ERG-transmembrane protease, serine 2 fusion. Fifty cases of carcinoma prostate diagnosed in needle biopsies and prostatic chips, in the Department of Pathology of a tertiary care teaching hospital in Punjab, India, were included in the present study. The slides were observed under the light microscope, and Gleason scoring was done using the 2005 International Society of Urological Pathology modified Gleason system. IHC study for ERG expression was done on all the cases, for which anti-ERG monoclonal rabbit clone antibody EP111 (Dako, Denmark) was used. Lymphocytes and endothelial cells were taken as in built positive controls for staining. The intensity of ERG positivity was scored as no staining (0), weak staining (+1), moderate staining (+2) and intense staining (+3). The H score was then calculated by multiplying the intensity of the stain with the percentage (0-100) of the cells showing that staining intensity. The H-score has a range of 0-300. The relationship between IHC expression and clinico-pathological parameters was compared and analyzed using Chi-square test. P < 0.05 was considered statistically significant. Majority of patients included in the study were in the age group of 61-80 (84% of the total). When ERG expression was studied with age

  7. Evolução histórica do conceito ambiente proposto no modelo da adaptação de Roy

    OpenAIRE

    Lopes, Marcos Venícios de Oliveira; Pagliuca, Lorita Marlena Freitag; Araujo, Thelma Leite de

    2006-01-01

    The concern for the development of concepts becomes even more important when we report to its use in Nursing theories, in which some concepts are considered central, such as person, environment, health and nursing. This study aims to discuss the historical evolution of the environment concept used in the Roy Adaptation Model. The method of analysis the study was based on is the evolutionary conceptual analysis of the concept Environment of the Roy Adaptation Model. According to the research r...

  8. Correlation of apparent diffusion coefficient ratio on 3.0 T MRI with prostate cancer Gleason score.

    Science.gov (United States)

    Jyoti, Rajeev; Jain, Tarun Pankaj; Haxhimolla, Hodo; Liddell, Heath; Barrett, Sean Edward

    2018-01-01

    The purpose was to investigate the usefulness of ADC ratio on Diffusion MRI to discriminate between benign and malignant lesions of Prostate. Images of patients who underwent in-gantry MRI guided prostate lesion biopsy were retrospectively analyzed. Prostate Cancers with 20% or more Gleason score (GS) pattern 3 + 3 = 6 in each core or any volume of higher Gleason score pattern were included. ADC ratio was calculated by two reviewers for each lesion. The ADC ratio was calculated for each lesion by dividing the lowest ADC value in a lesion and highest ADC value in normal prostate in peripheral zone (PZ). ADC ratio values were compared with the biopsy result. Data was analysed using independent samples T-test, Spearman correlation, intra-class correlation coefficient (ICC) and Receiver operating characteristic (ROC) curve. 45 lesions in 33 patients were analyzed. 12 lesions were in transitional zone (TZ) and 33 in perpheral zone PZ. All lesions demonstrated an ADC ratio of 0.45 or lower. GS demonstrated a negative correlation with both the ADC value and ADC ratio . However, ADC ratio (p correlation compared to ADC value alone (p = 0.014). There was no significant statistical difference between GS 3 + 4 and GS 4 + 3 mean ADC tumour value (p = 0.167). However when using ADC ratio , there was a significant difference (p = 0.032). ROC curve analysis demonstrated an area under the curve of 0.83 using ADC ratio and 0.76 when using ADC tumour value when discriminating Gleason 6 from Gleason ≥7 tumours. Inter-observer reliability in the calculation of ADC ratios was excellent, with ICC of 0.964. ADC ratio is a reliable and reproducible tool in quantification of diffusion restriction for clinically significant prostate cancer foci.

  9. Differentiation of prostate cancer lesions with high and with low Gleason score by diffusion-weighted MRI

    Energy Technology Data Exchange (ETDEWEB)

    Barbieri, Sebastiano; Broennimann, Michael; Vermathen, Peter; Thoeny, Harriet C. [Inselspital University Hospital, Institute of Diagnostic, Pediatric, and Interventional Radiology, Bern (Switzerland); Boxler, Silvan [Inselspital, Inselspital University Hospital, Department of Urology, Bern (Switzerland)

    2017-04-15

    To differentiate prostate cancer lesions with high and with low Gleason score by diffusion-weighted-MRI (DW-MRI). This prospective study was approved by the responsible ethics committee. DW-MRI of 84 consenting prostate and/or bladder cancer patients scheduled for radical prostatectomy were acquired and used to compute apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM: the pure diffusion coefficient D{sub t}, the pseudo-diffusion fraction F{sub p} and the pseudo-diffusion coefficient D{sub p}), and high b value (as acquired and Hessian filtered) parameters within the index lesion. These parameters (separately and combined in a logistic regression model) were used to differentiate lesions depending on whether whole-prostate histopathological analysis after prostatectomy determined a high (≥7) or low (6) Gleason score. Mean ADC and D{sub t} differed significantly (p of independent two-sample t test < 0.01) between high- and low-grade lesions. The highest classification accuracy was achieved by the mean ADC (AUC 0.74) and D{sub t} (AUC 0.70). A logistic regression model based on mean ADC, mean F{sub p} and mean high b value image led to an AUC of 0.74 following leave-one-out cross-validation. Classification by IVIM parameters was not superior to classification by ADC. DW-MRI parameters correlated with Gleason score but did not provide sufficient information to classify individual patients. (orig.)

  10. Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants

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    Terrence M. Vance

    2015-01-01

    Full Text Available Background. Prostate cancer is the most common noncutaneous cancer and second leading cause of cancer-related mortality in men in the US. Growing evidence suggests that oxidative stress is involved in prostate cancer. Methods. In this study, thioredoxin 1 (Trx 1, an enzyme and subcellular indicator of redox status, was measured in prostate biopsy tissue from 55 men from the North Carolina-Louisiana Prostate Cancer Project. A pathologist blindly scored levels of Trx 1. The association between Trx 1 and the Gleason score, erythrocyte antioxidant enzyme activity, and dietary antioxidant intake was determined using Fisher’s exact test. Results. Trx 1 levels in benign prostate tissue in men with incident prostate cancer were positively associated with the Gleason score (P=0.01 and inversely associated with dietary antioxidant intake (P=0.03. In prostate cancer tissue, Trx 1 levels were associated with erythrocyte glutathione peroxidase activity (P=0.01. No association was found for other erythrocyte enzymes. Greater Gleason score of malignant tissue corresponds to a greater difference in Trx 1 levels between malignant and benign tissue (P=0.04. Conclusion. These results suggest that the redox status of prostate tissue is associated with prostate cancer grade and both endogenous and exogenous antioxidants.

  11. Prediction of extraprostatic extension by prostate specific antigen velocity, endorectal MRI, and biopsy Gleason score in clinically localized prostate cancer

    International Nuclear Information System (INIS)

    Nishimoto, Koshiro; Nakashima, Jun; Hashiguchi, Akinori; Kikuchi, Eiji; Miyajima, Akira; Nakagawa, Ken; Ohigashi, Takashi; Oya, Mototsugu; Murai, Masaru

    2008-01-01

    The objective of this study was to investigate the clinical value of prostate specific antigen velocity (PSAV) in predicting the extraprostatic extension of clinically localized prostate cancer. One hundred and three patients who underwent radical prostatectomy for clinically localized prostate cancer were included in the analysis. The correlation between preoperative parameters, including PSA-based parameters, clinical stage, and histological biopsy findings, and the pathological findings were analyzed. Logistic regression analysis was performed to identify a significant set of independent predictors for the local extent of the disease. Sixty-four (60.2%) patients had organ confined prostate cancer and 39 (39.8%) patients had extraprostatic cancer. The biopsy Gleason score, PSA, PSA density, PSA density of the transition zone, and PSAV were significantly higher in the patients with extraprostatic cancer than in those with organ confined cancer. Multivariate logistic regression analysis indicated that the biopsy Gleason score, endorectal magnetic resonance imaging findings, and PSAV were significant predictors of extraprostatic cancer (P<0.01). Probability curves for extraprostatic cancer were generated using these three preoperative parameters. The combination of PSAV, endorectal magnetic resonance imaging findings, and biopsy Gleason score can provide additional information for selecting appropriate candidates for radical prostatectomy. (author)

  12. The novel nomogram of Gleason sum upgrade: possible application for the eligible criteria of low dose rate brachytherapy.

    Science.gov (United States)

    Budäus, Lars; Graefen, Markus; Salomon, Georg; Isbarn, Hendrik; Lughezzani, Giovanni; Sun, Maxine; Chun, Felix K H; Schlomm, Thorsten; Steuber, Thomas; Haese, Alexander; Koellermann, Jens; Sauter, Guido; Fisch, Margit; Heinzer, Hans; Huland, Hartwig; Karakiewicz, Pierre I

    2010-10-01

    To examine the rate of Gleason sum upgrading (GSU) from a sum of 6 to a Gleason sum of ≥7 in patients undergoing radical prostatectomy (RP), who fulfilled the recommendations for low dose rate brachytherapy (Gleason sum 6, prostate-specific antigen ≤10 ng/mL, clinical stage ≤T2a and prostate volume ≤50 mL), and to test the performance of an existing nomogram for prediction of GSU in this specific cohort of patients. The analysis focused on 414 patients, who fulfilled the European Society for Therapeutic Radiation and Oncology and American Brachytherapy Society criteria for low dose rate brachytherapy (LD-BT) and underwent a 10-core prostate biopsy followed by RP. The rate of GSU was tabulated and the ability of available clinical and pathological parameters for predicting GSU was tested. Finally, the performance of an existing GSU nomogram was explored. The overall rate of GSU was 35.5%. When applied to LD-BT candidates, the existing nomogram was 65.8% accurate versus 70.8% for the new nomogram. In decision curve analysis tests, the new nomogram fared substantially better than the assumption that no patient is upgraded and better than the existing nomogram. GSU represents an important issue in LD-BT candidates. The new nomogram might improve patient selection for LD-BT and cancer control outcome by excluding patients with an elevated probability of GSU. © 2010 The Japanese Urological Association.

  13. Comments on Timothy F. Murphy's 'the afterlife of embryonic persons: what a strange place heaven must be'.

    Science.gov (United States)

    Head, Ivan F

    2012-12-01

    In this issue, Timothy F. Murphy has written a thought-provoking and carefully nuanced article that focuses on the question of a link between a first moment of conception and an end-state beyond death in the resurrection of a human person. He is particularly concerned to probe the theological implications of asserting that the person exists from the moment of conception, and he does so by asking the reader to imagine what kind of resurrected persons would thus populate a heaven filled with, for instance, the resurrected that had in this biotic life lived but a few hours post conception, or had, say, a CV that covered no more than 5 days of cellular replication. By implication, he asks us to imagine a resurrected person whose earthly life lacked memory, consciousness or bodily form, and rather had persisted as a cluster of undifferentiated pluripotent cells. Murphy's candid and fair treatment of these topics is a helpful invitation to some theologians to follow more thoroughly all implications of dogmatically held positions and to consider more thoroughly new ways of thinking of the person as an emergent reality. Copyright © 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  14. MUSLIM-CHRISTIAN DEBATES IN THEEARLY ‘ABBASID PERIOD: The Cases of Timothy I and Theodore Abu Qurra

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    Hans Abdiel Harmakaputra

    2014-12-01

    Full Text Available The era of the early ‘Abbasid caliphate made an important mark on the history of the world by the event of the Greek translation movement, i.e. the translation of Greek thoughts into the Arabic language. In addition to this development, the era also saw the flourishing of interreligious discourse, in both polemical literatures and religious debates, especially between Christians and Muslims. This article tries to describe how those two historical remarks are correlated under the light of other factors such as politics and religious identity. The earliest debate was happened between caliph al-Mahdi (r. 755-785 CE and a Nestorian Catholicos, Timothy I (728- 823 CE, as the first sample of religious discourses. The second one is the debate between the caliph al-Ma’mun (r. 813-833CE, who arranged many religious debates in his court, with Theodore Abu Qurra (755 – 830 CE, Bishop of Harran. By knowing the motives of the two caliphs who sponsored those events, readers would catch a better picture of the historical contexts of that time.

  15. Markers of epithelial-to-mesenchymal transition reflect tumor biology according to patient age and Gleason score in prostate cancer.

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    Dorota Jędroszka

    Full Text Available Prostate carcinoma (PRAD is one of the most frequently diagnosed malignancies amongst men worldwide. It is well-known that androgen receptor (AR plays a pivotal role in a vast majority of prostate tumors. However, recent evidence emerged stating that estrogen receptors (ERs may also contribute to prostate tumor development. Moreover, progression and aggressiveness of prostate cancer may be associated with differential expression genes of epithelial-to-mesenchymal transition (EMT. Therefore we aimed to assess the significance of receptors status as well as EMT marker genes expression among PRAD patients in accordance to their age and Gleason score.We analyzed TCGA gene expression profiles of 497 prostate tumor samples according to 43 genes involved in EMT and 3 hormone receptor genes (AR, ESR1, ESR2 as well as clinical characteristic of cancer patients. Then patients were divided into four groups according to their age and 5 groups according to Gleason score. Next, we evaluated PRAD samples according to relationship between the set of variables in different combinations and compared differential expression in subsequent groups of patients. The analysis was applied using R packages: FactoMineR, gplots, RColorBrewer and NMF.MFA analysis resulted in distinct grouping of PRAD patients into four age categories according to expression level of AR, ESR1 and ESR2 with the most distinct group of age less than 50 years old. Further investigations indicated opposite expression profiles of EMT markers between different age groups as well as strong association of EMT gene expression with Gleason score. We found that depending on age of prostate cancer patients and Gleason score EMT genes with distinctly altered expression are: KRT18, KRT19, MUC1 and COL4A1, CTNNB1, SNAI2, ZEB1 and MMP3.Our major observation is that prostate cancer from patients under 50 years old compared to older ones has entirely different EMT gene expression profiles showing potentially

  16. A relação entre os modos adaptativos de ROY e a taxonomia de diagnósticos de enfermagem da NANDA La relación entre los modos adaptativos de ROY y la taxonomía de diagnósticos de enfermería de la NANDA The relationship among the adaptation modes of ROY and NANDA taxonomy of nursing diagnoses

    Directory of Open Access Journals (Sweden)

    Marcos Venícios de Oliveira Lopes

    1999-10-01

    Full Text Available Estudo teórico-reflexivo objetivando estabelecer uma correlação entre a taxonomia de diagnósticos da NANDA e os modos adaptativos propostos por Roy. Foram definidas as relações entre os indicadores de adaptação positiva, os problemas comuns de adaptação propostos por Roy e os diagnósticos de enfermagem da NANDA. Os resultados nos permitiram perceber uma forte correspondência entre os conceitos existentes no modelo teórico estudado e a taxonomia de diagnósticos de enfermagem da NANDA. Concluímos que existe a possibilidade de operacionalizar o uso dos diagnósticos de enfermagem da NANDA tendo como base o processo de enfermagem fundamentado na teoria da Adaptação de Roy.Estudio teórico-reflexivo buscando establecer una correlación entre los diagnósticos de enfermería de la NANDA y los modos adaptativos propuestos por Roy. Fueron definidas las relaciones entre los indicadores de adaptación positiva, los problemas comunes de adaptación propuestos por Roy y los diagnósticos de enfermería de la NANDA. Los resultados permitieron ver una correlación fuerte entre los conceptos existentes en el modelo teórico estudiado y la taxonomía de la NANDA de diagnósticos de enfermería. Nosotros concluimos que existe la posibilidad de operacionalizar el uso de los diagnósticos de enfermería de la NANDA teniendo como base el proceso de enfermería basado en la teoría de la Adaptación de Roy.The present study is theoretical-reflexive with the purpose to establish a correlation between NANDA's taxonomy diagnoses and the adaptation modes proposed by Roy. Authors defined the relationships among the indicators of positive adaptation, the common problems of adaptation proposed by Roy and NANDA's nursing diagnoses. Results showed a strong correspondence between the existent concepts in the studied theoretical model and NANDA's taxonomy of nursing diagnoses. Authors concluded that there is a possibility of using NANDA's nursing diagnoses and

  17. Modelo de adaptación de Roy en el baño en cama

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    José Manuel Flórez Ramos

    2016-09-01

    Full Text Available Objetivo: Evaluar los efectos de dos tipos de baño en cama: seco y tradicional, frente a la respuesta adaptativa en modo fisiológico de Roy en paciente crítico cardiovascular (pccv. Metodología: Estudio de diseño cuasi-experimental, de intervención con preprueba y posprueba, realizado en la Unidad de Cuidados Intensivos (uci de la Clínica Medellín. El grupo experimental fue de 36 pacientes, a quienes se les realizó baño en cama seco; el grupo control fue de 36 pacientes, a quienes se les realizó baño en cama tradicional. Se utilizaron los estadísticos Wilcoxon, u de Mann Whitney y el Modelo de dos factores, con medidas repetidas en un factor. Resultados: Se encontró un efecto benéfico durante la realización del baño en cama en seco, puesto que los indicadores de tensión arterial y frecuencia respiratoria no presentaron respuestas inefectivas (p = 0,03 y p = 0,013, respectivamente. Por otra parte, las variables duración del baño y cuidados adicionales fueron satisfactorias en comparación con el baño en cama tradicional. Conclusiones: Los resultados permiten recomendar el uso del baño en cama en seco en paciente crítico cardiovascular (pccv, en virtud de los efectos benéficos que facilitan los procesos de adaptación, contribuyendo así a cualificar el cuidado de enfermería en este tipo de pacientes.

  18. Cascaded discrimination of normal, abnormal, and confounder classes in histopathology: Gleason grading of prostate cancer

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    Doyle Scott

    2012-10-01

    Full Text Available Abstract Background Automated classification of histopathology involves identification of multiple classes, including benign, cancerous, and confounder categories. The confounder tissue classes can often mimic and share attributes with both the diseased and normal tissue classes, and can be particularly difficult to identify, both manually and by automated classifiers. In the case of prostate cancer, they may be several confounding tissue types present in a biopsy sample, posing as major sources of diagnostic error for pathologists. Two common multi-class approaches are one-shot classification (OSC, where all classes are identified simultaneously, and one-versus-all (OVA, where a “target” class is distinguished from all “non-target” classes. OSC is typically unable to handle discrimination of classes of varying similarity (e.g. with images of prostate atrophy and high grade cancer, while OVA forces several heterogeneous classes into a single “non-target” class. In this work, we present a cascaded (CAS approach to classifying prostate biopsy tissue samples, where images from different classes are grouped to maximize intra-group homogeneity while maximizing inter-group heterogeneity. Results We apply the CAS approach to categorize 2000 tissue samples taken from 214 patient studies into seven classes: epithelium, stroma, atrophy, prostatic intraepithelial neoplasia (PIN, and prostate cancer Gleason grades 3, 4, and 5. A series of increasingly granular binary classifiers are used to split the different tissue classes until the images have been categorized into a single unique class. Our automatically-extracted image feature set includes architectural features based on location of the nuclei within the tissue sample as well as texture features extracted on a per-pixel level. The CAS strategy yields a positive predictive value (PPV of 0.86 in classifying the 2000 tissue images into one of 7 classes, compared with the OVA (0.77 PPV and OSC

  19. Pessoas com úlceras venosas: estudo do modo psicossocial do modelo adaptativo de Roy Personas con úlceras venosas: estudio de los aspectos psicosociales del modelo de adaptación de Roy People with venous ulcers: a study of the psychosocial aspects of the adaptive model of Roy

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    Isabelle Katherinne Fernandes Costa

    2011-09-01

    Full Text Available Estudo transversal, descritivo, quantitativo, realizado com 50 pessoas com úlcera venosa (UV em um Hospital Universitário, que objetivou verificar o nível de adaptação psicossocial do Modelo de Roy das pessoas com UV. A pesquisa foi aprovada pelo Comitê de Ética da instituição. Os dados foram coletados com formulário estruturado e após a organização dos dados das alterações ocorridas na vida das pessoas com UV classificamos segundo o modo psicossocial de Roy. Verificamos que no modo autoconceito, 36% sentiam-se insatisfeitos com aparência física, 18% apresentavam sentimentos negativos; no modo desempenho de papéis: alteração no papel laboral (52,0%, atividades domésticas (34,0%, conjugal (6,0%, restrições de lazer, dor, social, escolar e locomoção (82,0%; no modo de interdependência: apoio no tratamento (82,0%, discriminação (58,0%. A identificação do modo psicossocial direciona as ações de enfermagem abrangendo a pessoa que recebe o cuidado considerando-a no todo em suas relações com ambiente promovendo melhor nível de adaptação.Estudio transversal, descriptivo, cuantitativo realizado con 50 personas con úlcera venosa (UV en el Hospital Universitario que objetivó conocer nivel de adaptación psicosocial del modelo de Roy de las personas con UV. Estudio aprobado por el Comité de Ética (nº 279/09. Los datos fueron recogidos mediante formulario y después de organizar los datos de los cambios en la vida de las personas con UV, fueron clasificados de acuerdo con los aspectos psicosociales de Roy. Verificamos en el modo de auto-concepto: 36% insatisfacción con apariencia física, 18% sentimientos negativos, desempeño de papel: cambio en el papel de trabajo (52,0%, tareas domésticas (34,0%, estado civil (6,0%, restricción de ocio, dolor, sociales, educativos y transporte (82,0%; modo de interdependencia: apoyo en el tratamiento (82,0%, discriminación (58,0%. La identificación de aspectos psicosociales

  20. Adaptación psicosocial de los adolescentes pos-trasplante renal, según la teoría de Roy Adaptação psicossocial do adolescente pós-trasplante renal segundo a teoria de Roy Psicosocial adaptation of post-renal transplanted adolescents according to Roy Theory

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    Ana Luisa Brandão de Carvalho Lirax

    2005-03-01

    Full Text Available El objetivo de este trabajo fue conocer las repercusiones psicosociales del adolescente después del trasplante renal y los mecanismos de adaptación utilizados en su nueva condición de vida. Es un estudio cualitativo, mediante entrevistas estructuradas. Fueron entrevistados diecinueve adolescentes que estaban en acompañamiento en dos hospitales públicos de Ceará-Brasil, después de la aprobación del proyecto por parte del Comité de Ética de las Instituciones y obtención del consentimiento libre e informado. Los resultados fueron analizados conforme a la teoría de la adaptación de Roy. Se identificaron problemas de adaptación, como: limitación física, vergüenza, miedo al rechazo e impotencia. Sin embargo, esos adolescentes pudieron superar tal situación y mejorar la adaptación a su nueva condición. Concluimos que la teoría de Roy permitió un análisis más profundo de los adolescentes, permitiéndoles un tratamiento más eficaz y, consecuentemente, una mejor calidad de vida.É um estudo descritivo, com análise qualitativo. O objetivo deste trabalho foi conhecer as repercussões psicossociais do adolescente após o trasplante renal e os mecanismos adaptativos utilizados por estes na sua nova condição de vida. Foram entrevistados dezenove adolescentes que estavam em acompanhamento ambulatorial em dois hospitais públicos do Ceará-Brasil, após aprovação do projeto pelo Comitê de Ética das Instituições e obtenção do consentimento livre e esclarecido. Os resultados foram analisados conforme a teoria da adaptação de Roy. Foram identificados problemas de adaptação, como: limitação física, vergonha, medo de rejeição e impotência. Contudo, esses adolescentes puderam superar tal situação e melhorar a adaptação à sua nova condição. Concluímos que a teoria de Roy permitiu uma análise mais aprofundada desses adolescentes, permitindo lhes um tratamento mais eficaz e, conseqüentemente, uma melhor qualidade de

  1. Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population

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    Anthony S. Perry

    2014-01-01

    Full Text Available Background. Levels of the protein kinase aPKC have been previously correlated with prostate cancer prognosis in a British cohort. However, prostate cancer incidence and progression rates, as well as genetic changes in this disease, show strong ethnic variance, particularly in Asian populations. Objective. The aim of this study was to validate association of aPKC expression with prostatic adenocarcinoma stages in a Japanese cohort. Methods. Tissue microarrays consisting of 142 malignant prostate cancer cases and 21 benign prostate tissues were subject to immunohistological staining for aPKC. aPKC staining intensity was scored by three independent pathologists and categorized as absent (0, dim (1+, intermediate (2+, and bright (3+. aPKC staining intensities were correlated with Gleason score and tumor stage. Results. Increased aPKC staining was observed in malignant prostate cancer, in comparison to benign tissue. Additionally, aPKC staining levels correlated with Gleason score and tumor stage. Our results extend the association of aPKC with prostate cancer to a Japanese population and establish the suitability of aPKC as a universal prostate cancer biomarker that performs consistently across ethnicities.

  2. Gross anatomy of the gastrointestinal tract in reindeer, free-living and fed baled timothy silage in summer and winter

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    Tove H. Aagnes

    1996-01-01

    Full Text Available The gross anatomy of the gastrointestinal (GI tract was investigated in reindeer calves (Rangtfer tarandus tarandus, free-living and fed two different qualities of timothy silage in September 1992 (summer and April 1993 (winter and related to the body condition. At both seasons nine male reindeer calves were taken from a natural pasture. Three animals were slaughtered directly (NP reindeer, three offered first cut (FC silage and three regrowth (RG silage ad lib., for 46 days. The FC silage contained 27% leaves and 57.8% dry matter (DM cell wall content (CWC and the RG silage 89 % leaves, and 38.7% DM CWC. The reticulo-rumen (RR digesta wet weight in the NP reindeer in summer was 6.7-7.7% of body mass (BM, compared to 25.1-32.8% and 9.6-12.9% of BM, respectively, in the animals fed FC and RG silage. In winter the RR digesta wet weight relative to BM in the NP reindeer and in the animals fed FC and RG silages were 9-5-11.5%, 25.4-33.3% and 10.4-18.3%, respectively. The distal fermentation chamber (DFC digesta wet weight in the NP animals in summer was 0.48-0.80% of BM, compared to 0.77-1.26% and 0.57¬0.65% of BM, respectively, in the animals fed FC and RG silage. In winter the DFC digesta wet weight relative to BM in the animals fed FC and RG silage did not differ significantly from the summer values (P>0.05, while in the NP reindeer it was 1.0-1.2% of BM which is significantly greater than in summer (P<0.05. The differences in relative weight of the fermentation chambers between the animals fed FC and RG silage both summer and winter were not reflected in total BM, which was similar in all groups fed silage. This is explained by a significantly lower carcass weight in the animals fed FC silage compared to the animals fed RG silage. Thus, the GI-tract gross anatomy in the silage fed animals seem to be highly affected by the plant structure and composition, and not by the season.

  3. Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities in prostate cancer patients: influence of Gleason score, treatment and bone metastasis.

    Science.gov (United States)

    Battisti, Vanessa; Maders, Liési D K; Bagatini, Margarete D; Battisti, Iara E; Bellé, Luziane P; Santos, Karen F; Maldonado, Paula A; Thomé, Gustavo R; Schetinger, Maria R C; Morsch, Vera M

    2013-04-01

    The relation between adenine nucleotides and cancer has already been described in literature. Considering that the enzymes ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) act together to control nucleotide levels, we aimed to investigate the role of these enzymes in prostate cancer (PCa). E-NPP and ADA activities were determined in serum and platelets of PCa patients and controls. We also verified the influence of the Gleason score, bone metastasis and treatment in the enzyme activities. Platelets and serum E-NPP activity increased, whereas ADA activity in serum decreased in PCa patients. In addition, Gleason score, metastasis and treatment influenced E-NPP and ADA activities. We may propose that E-NPP and ADA are involved in the development of PCa. Moreover, E-NPP and ADA activities are modified in PCa patients with distinct Gleason score, with bone metastasis, as well as in patients under treatment. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  4. Clinical Validation of the 2005 ISUP Gleason Grading System in a Cohort of Intermediate and High Risk Men Undergoing Radical Prostatectomy.

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    Sheila F Faraj

    Full Text Available In 2005, the International Society of Urological Pathology (ISUP introduced several modifications to the original Gleason system that were intended to enhance the prognostic power of Gleason score (GS. The objective of this study was to clinically validate the 2005 ISUP Gleason grading system for its ability to detect metastasis. We queried our institutional RP database for men with NCCN clinically localized intermediate to high-risk disease undergoing radical prostatectomy (RP between 1992 and 2010 with no additional treatment until the time of metastatic progression. A case-cohort design was utilized. A total of 333 available RP samples were re-reviewed and GS was reassigned per the 2005 ISUP Gleason system. Cumulative incidence of metastasis was 0%, 8.4%, 24.5% and 44.4% among specimens that were downgraded, unchanged, had one point GS increase and two point GS increase, respectively. The hazard ratio for metastasis raised in GS 8 and 9 compared to GS 7 from 2.77 and 5.91 to 3.49 and 9.31, respectively. The survival c-index of GS increased from 0.70 to 0.80 when samples were re-graded at 5 years post RP. The c-index of the reassigned GS was higher than the original GS (0.77 vs 0.64 for predicting PCSM at 10 years post RP. The regraded GS improved the prediction of metastasis and PCSM. This validates the updated Gleason grading system using an unambiguous clinical endpoint and highlights the need for reassignment of Gleason grading according to 2005 ISUP system when considering comparisons of novel biomarkers to clinicopathological variables in archival cohorts.

  5. The K*0(800) scalar resonance from Roy-Steiner representations of πK scattering

    International Nuclear Information System (INIS)

    Descotes-Genon, S.; Moussallam, B.

    2006-01-01

    We discuss the existence of the light scalar meson K * 0 (800) (also called κ) in a rigorous way, by showing the presence of a pole in the πK→πK amplitude on the second Riemann sheet. For this purpose, we study the domain of validity of two classes of Roy-Steiner representations in the complex energy plane. We prove that one of them is valid in a region sufficiently broad in the imaginary direction. From this representation, we compute the l=0 partial wave in the complex plane neither making any additional approximation nor having model dependence, relying only on experimental data. A scalar resonance with strangeness S=1 is found with the following mass and width: M κ =658±13 MeV and Γ κ =557±24 MeV. (orig.)

  6. The histogram analysis of diffusion-weighted intravoxel incoherent motion (IVIM) imaging for differentiating the gleason grade of prostate cancer.

    Science.gov (United States)

    Zhang, Yu-Dong; Wang, Qing; Wu, Chen-Jiang; Wang, Xiao-Ning; Zhang, Jing; Liu, Hui; Liu, Xi-Sheng; Shi, Hai-Bin

    2015-04-01

    To evaluate histogram analysis of intravoxel incoherent motion (IVIM) for discriminating the Gleason grade of prostate cancer (PCa). A total of 48 patients pathologically confirmed as having clinically significant PCa (size > 0.5 cm) underwent preoperative DW-MRI (b of 0-900 s/mm(2)). Data was post-processed by monoexponential and IVIM model for quantitation of apparent diffusion coefficients (ADCs), perfusion fraction f, diffusivity D and pseudo-diffusivity D*. Histogram analysis was performed by outlining entire-tumour regions of interest (ROIs) from histological-radiological correlation. The ability of imaging indices to differentiate low-grade (LG, Gleason score (GS) ≤6) from intermediate/high-grade (HG, GS > 6) PCa was analysed by ROC regression. Eleven patients had LG tumours (18 foci) and 37 patients had HG tumours (42 foci) on pathology examination. HG tumours had significantly lower ADCs and D in terms of mean, median, 10th and 75th percentiles, combined with higher histogram kurtosis and skewness for ADCs, D and f, than LG PCa (p Histogram D showed relatively higher correlations (ñ = 0.641-0.668 vs. ADCs: 0.544-0.574) with ordinal GS of PCa; and its mean, median and 10th percentile performed better than ADCs did in distinguishing LG from HG PCa. It is feasible to stratify the pathological grade of PCa by IVIM with histogram metrics. D performed better in distinguishing LG from HG tumour than conventional ADCs. • GS had relatively higher correlation with tumour D than ADCs. • Difference of histogram D among two-grade tumours was statistically significant. • D yielded better individual features in demonstrating tumour grade than ADC. • D* and f failed to determine tumour grade of PCa.

  7. Gene expression relationship between prostate cancer cells of Gleason 3, 4 and normal epithelial cells as revealed by cell type-specific transcriptomes

    International Nuclear Information System (INIS)

    Pascal, Laura E; Liu, Alvin Y; Vêncio, Ricardo ZN; Page, Laura S; Liebeskind, Emily S; Shadle, Christina P; Troisch, Pamela; Marzolf, Bruz; True, Lawrence D; Hood, Leroy E

    2009-01-01

    Prostate cancer cells in primary tumors have been typed CD10 - /CD13 - /CD24 hi /CD26 + /CD38 lo /CD44 - /CD104 - . This CD phenotype suggests a lineage relationship between cancer cells and luminal cells. The Gleason grade of tumors is a descriptive of tumor glandular differentiation. Higher Gleason scores are associated with treatment failure. CD26 + cancer cells were isolated from Gleason 3+3 (G3) and Gleason 4+4 (G4) tumors by cell sorting, and their gene expression or transcriptome was determined by Affymetrix DNA array analysis. Dataset analysis was used to determine gene expression similarities and differences between G3 and G4 as well as to prostate cancer cell lines and histologically normal prostate luminal cells. The G3 and G4 transcriptomes were compared to those of prostatic cell types of non-cancer, which included luminal, basal, stromal fibromuscular, and endothelial. A principal components analysis of the various transcriptome datasets indicated a closer relationship between luminal and G3 than luminal and G4. Dataset comparison also showed that the cancer transcriptomes differed substantially from those of prostate cancer cell lines. Genes differentially expressed in cancer are potential biomarkers for cancer detection, and those differentially expressed between G3 and G4 are potential biomarkers for disease stratification given that G4 cancer is associated with poor outcomes. Differentially expressed genes likely contribute to the prostate cancer phenotype and constitute the signatures of these particular cancer cell types

  8. Importance of prostate-specific antigen (PSA as a predictive factor for concordance between the Gleason scores of prostate biopsies and RADICAL prostatectomy specimens

    Directory of Open Access Journals (Sweden)

    Nelson Gianni de Lima

    2013-06-01

    Full Text Available OBJECTIVE: To evaluate the concordance between the Gleason scores of prostate biopsies and radical prostatectomy specimens, thereby highlighting the importance of the prostate-specific antigen (PSA level as a predictive factor of concordance. METHODS: We retrospectively analyzed 253 radical prostatectomy cases performed between 2006 and 2011. The patients were divided into 4 groups for the data analysis and dichotomized according to the preoperative PSA, <10 ng/mL and ≥10 ng/mL. A p-score <0.05 was considered significant. RESULTS: The average patient age was 63.3±7.8 years. The median PSA level was 9.3±4.9 ng/mL. The overall concordance between the Gleason scores was 52%. Patients presented preoperative PSA levels <10 ng/mL in 153 of 235 cases (65% and ≥10 ng/mL in 82 of 235 cases (35%. The Gleason scores were identical in 86 of 153 cases (56% in the <10 ng/mL group and 36 of 82 (44% cases in the ≥10 ng/mL group (p = 0.017. The biopsy underestimated the Gleason score in 45 (30% patients in the <10 ng/mL group and 38 (46% patients in the ≥10 ng/mL (p = 0.243. Specifically, the patients with Gleason 3 + 3 scores according to the biopsies demonstrated global concordance in 56 of 110 cases (51%. In this group, the patients with preoperative PSA levels <10 ng/dL had higher concordance than those with preoperative PSA levels ≥10 ng/dL (61% x 23%, p = 0.023, which resulted in 77% upgrading after surgery in those patients with PSA levels ≥10 ng/dl. CONCLUSION: The Gleason scores of needle prostate biopsies and those of the surgical specimens were concordant in approximately half of the global sample. The preoperative PSA level was a strong predictor of discrepancy and might improve the identification of those patients who tended to be upgraded after surgery, particularly in patients with Gleason scores of 3 + 3 in the prostate biopsy and preoperative PSA levels ≥10 ng/mL.

  9. Relation of prostatic specific antigen, bone scan and Gleason score in prostate cancer Nuclear Medicine Center IPEN - INEN, 1993-1995

    International Nuclear Information System (INIS)

    Mendoza Perez, German E.

    2006-01-01

    Objectives: To establish the relationship of serum prostate specific antigen (PSA), Gleason score and bone scan, to determine bone metastases in prostate cancer patients (PC). Material and Methods: A retrospective cases and series study was performed in patients with prostate cancer derived to the Centre of Nuclear Medicine IPEN-INEN from 1993 to 1995. 165 patients were included. Frequency charts were done for every study variable, quantitative variables were expressed by mean ± SD; for qualitative variables percentages were used. To confirm relations a Chi-square (χ2) test was applied. Sensitivity, specificity, positive predictive value and negative predictive value for a 20 ng/mL cut off point of PSA and a Gleason score of 8 were carried out using contingency charts. Diagnostic performance of this tests were performed applying R.O.C. curve. Results: Mean age was 71.27 ± 7.6 years. Bone metastases were found in 84 (50.9%) patients. For a 20 ng/mL PSA, sensitivity was of 0.92, specificity of 0.47, PPV of 0.64 and NPV of 0.84; for a Gleason score of 8, sensitivity was 0.59, specificity 0.69, PPV O.67 and NPV 0.62. The probability to have a positive bone scan with a Gleason score of 8 is up to 10% for ≤ 4 ng/mL PSA; 15% for ≤ 10 ng/mL PSA, and 20% if PSA level is ≤ 20 ng/mL. Conclusions: We conclude, for the studied population, that it is necessary to perform a bone scan in all recently diagnosed prostate cancer patients, independently of PSA levels and Gleason score, in order to determine if bone metastases are present. (author)

  10. Complementary DNA cloning of the major allergen Phl p I from timothy grass (Phleum pratense); recombinant Phl p I inhibits IgE binding to group I allergens from eight different grass species

    NARCIS (Netherlands)

    Laffer, S.; Valenta, R.; Vrtala, S.; Susani, M.; van Ree, R.; Kraft, D.; Scheiner, O.; Duchêne, M.

    1994-01-01

    BACKGROUND: Grass pollens, such as pollen from timothy grass (Phleum pratense), represent a major cause of type I allergy. OBJECTIVE: In this report we attempted to determine how cross-reactive allergenic components of grass pollens from different species can be represented by a minimum number of

  11. Abordagem assistencial ao neonato portador de mielomeningocele segundo o modelo de adaptação de Roy Abordaje asistencial al neonato portador de mielomeningocele según el modelo de adaptación de Roy Care delivery to newborns with myelomeningocele according to Roy's adaptation model

    Directory of Open Access Journals (Sweden)

    Eloah de Paula Pessoa Gurgel

    2010-09-01

    Full Text Available O objetivo deste estudo de caso foi identificar os diagnósticos de Enfermagem de um bebê portador de mielomeningocele, internado na Unidade de Terapia Intensiva Neonatal (UTIN, abordando os aspectos fisiológicos segundo a Teoria de Adaptação de Roy, e elaborar ações de enfermagem pertinentes a estes aspectos. O estudo foi desenvolvido na UTIN da Maternidade Escola Assis Chateaubriand, na cidade de Fortaleza, Ceará, Brasil, nos meses de dezembro de 2007 a março de 2008, quando foi utilizado um roteiro de levantamento de dados. Na análise, reconheceram-se os diagnósticos: padrão respiratório ineficaz; nutrição desequilibrada: menos do que as necessidades corporais; integridade da pele prejudicada; risco para infecção e percepção sensorial perturbada. A utilização desta teoria permitiu reconhecer que o RN pode desencadear respostas positivas ou negativas mediante estímulos, e que as metas e intervenções implementadas foram importantes para a substituição de respostas ineficazes por respostas adaptativas.El objetivo de este estudio de caso fue identificar los diagnósticos de Enfermería, abordando los aspectos fisiológicos según la Teoría de Adaptación de Roy, de un bebé portador de mielomeningocele, internado en la Unidad de Terapia Intensiva Neonatal (UTIN, y elaborar acciones de enfermería pertinentes a tales aspectos. El estudio fue desarrollado en al UTIN de la Maternidad Escuela Assis Chateubriand, en la ciudad de Fortaleza-Ceará-Brasil, en los mese de diciembre de 2007 a marzo de 2008, momento en el cual fue utilizado un cuestionario para la colecta de datos. En el análisis, se reconocieron los diagnósticos: patrón diagnóstico ineficaz, nutrición desequilibrada (inferior a las necesidades corporales, integridad de la piel afectada, riesgo de infección y percepción sensorial perturbada. La utilización de esta teoría permitió reconocer que el RN puede desencadenar respuestas positivas o negativas a

  12. Afrontamientos de enfermeras al asumir la gerencia escolar: una mirada desde la teoría de Roy O afrontamento das enfermeiras ao assumirem a gerência escolar: um olhar a partir da teoria de Roy Confrontation of nurses when assuming the school management: a look from Roy's adaptation theory

    Directory of Open Access Journals (Sweden)

    Mariana Olizbeth Salinas Alvirde

    2012-06-01

    Full Text Available Esta investigación aborda la transición gerencial de las instituciones educativas de médicos a enfermeras con objetivo de delimitar mecanismos de afrontamiento y modos adaptativos al iniciar la gestión en el entorno académico. Se realizó estudio cualitativo de corte histórico-social sustentado por la teoría de adaptación de Roy. Los sujetos estudiados fueron las primeras profesoras que ocuparon la dirección de escuelas universitarias de enfermería, a través de entrevistas se recolectaron los datos. Los resultados revelaron que la incursión de enfermeras permitió abordar el proceso salud-enfermedad de manera distinta al acto médico, lo que significó generar mecanismos de afrontamiento para trabajar en la construcción de paradigmas que conformarán un pensamiento profesional y visión disciplinaria propia, a través de un plan de estudio solido. Concluímos que se renovaron los métodos de trabajo, creándose nuevos niveles académicos, especializaciones y titularidades en las materias en base a sacrificio y dedicación, iniciándose su autonomía profesional.Esta pesquisa aborda a transição gerencial das instituiçðes educativas de médicos às enfermeiras, com o objetivo de delimitar mecanismos de afrontamento e modos adaptativos ao iniciar a gestão no âmbito acadêmico. Realizou-se um estudo qualitativo de abordagem histórico-social, orientado pela teoria de adaptação de Roy. Os sujeitos estudados foram as primeiras professoras que ocuparam a direção das escolas universitárias de enfermagem; os dados foram recoletados por meio de entrevistas. Os resultados revelaram que a incursão de enfermeiras permitiu abordar o processo saúde-doença de maneira distinta ao ato médico, o que significou gerar mecanismos de afrontamento para trabalhar na construção de paradigmas que conformarão um pensamento profissional e uma visão disciplinar própria, a partir de um plano de estudo sólido. Concluiu-se que se renovarão os

  13. Assistência de enfermagem a portadores de anemia falciforme, à luz do referencial de Roy Atención de enfermería a portadores de anemia falciforme apoyada en el modelo conceptual de Roy Nursing care to patiens with sickle cell disease in the light of Roy's model

    Directory of Open Access Journals (Sweden)

    Maria Lúcia Ivo

    2003-03-01

    Full Text Available O presente estudo busca aplicar os conceitos do modelo de Adaptação de Roy para identificar os comportamentos (adaptativos e inefetivos de pacientes portadores de anemia falciforme, bem como os estímulos focais, contextuais e residuais responsáveis por tais comportamentos. A coleta de dados foi realizada no Ambulatório de Hemoglobinopatias do HCFMRP-USP. Foram sujeitos 9 pacientes (8 mulheres e 1 homem. Evidenciou-se, no modo fisiológico, o comportamento inefetivo de baixa oxigenação e suas conseqüências (desenvolvimento físico comprometido, retardo sexual, icterícia por hemólise, alterações respiratórias. No modo psicossocial, o autoconceito teve a diminuição da auto-estima como o comportamento mais destacado; o desempenho de papel foi caracterizado por mudanças de ocupação; quanto à interdependência, a mãe foi referida como o outro significante mais freqüente. Identificou-se, predominantemente, como estímulo causador dos comportamentos inefetivos, a vaso-oclusão. Verificou-se que a função fisiológica afetada altera os outros modos adaptativos.Este estudio busca aplicar los conceptos del modelo de adaptación de Roy para identificar los comportamientos (adaptativos e inefectivos de pacientes portadores de anemia falciforme, así como también como los estímulos focales, contextuales y residuales responsables por estos comportamientos. La recolección de datos fue realizada en la consulta externa de Hemoglobinopatias del HCFMRP-USP. Fueron sujetos 9 pacientes (8 mujeres y 1 hombre. Los resultados evidenciaron, en el modo fisiológico, el comportamiento inefectivo de baja oxigenación y sus consecuencias (desarrollo físico comprometido, retardo sexual, ictericia por hemólisis, alteraciones respiratorias. En el modo psicosocial y considerando el autoconcepto, fue observada la disminución de la auto estima como el comportamiento más destacado; el desempeño del rol fue caracterizado por cambios de ocupaci

  14. UMTRA water sampling technical (peer) review: Responses to observations, comments, and recommendations submitted by Don Messinger (Roy F. Weston, Inc.)

    International Nuclear Information System (INIS)

    1993-08-01

    An independent technical review (peer review) was conducted during the period of September 15--17, 1992. The review was conducted by C. Warren Ankerberg (Geraghty and Miller, Inc., Tampa, Florida) and Don Messinger (Roy F. Weston, Inc., West Chester, Pennsylvania). The review was held at Jacobs Engineering in Albuquerque, New Mexico, and at the Shiprock, New Mexico, site. The peer review included a review of written documentation [water sampling standard operating procedures (SOP)], an inspection of technical reports and other deliverables, a review of staff qualifications and training, and a field visit to evaluate the compliance of field procedures with SOPS. Upon completion of the peer review, each reviewer independently prepared a report of findings from the review. The reports listed findings and recommended actions. This document responds to the observations, comments, and recommendations submitted by Don Messinger following his review. The format of this document is to present the findings and recommendations verbatim from Mr. Messinger's report, followed by responses from the UMTRA Project staff. Included in the responses from the UMTRA Project staff are recommended changes in SOPs and strategies for implementing the charges

  15. Adaptación en pacientes con diabetes Mellitus Tipo 2, según Modelo de Roy

    Directory of Open Access Journals (Sweden)

    Margarita Lazcano-Ortiz

    2009-01-01

    Full Text Available Objetivo. Determinar la influencia entre estímulos focales y contextuales, y la adaptación fisiológica y psicosocial en personas con diabetes Mellitus Tipo 2 (DMT2. Material y método. El diseño fue descriptivo, transversal, predictivo. El muestreo fue probabilístico, sistemático. La muestra con 200 participantes de ambos géneros de 30 a 65 años, se determinó para un 95% de confianza, con una potencia de prueba de 90%. Resultados. Los resultados mostraron que el tiempo desde diagnóstico explicó la adaptación fisiológica F (1,198 = 9,18, p = ,003. Se observó efecto entre complicaciones y adaptación psicosocial F (4,195 = 4,97, p = ,001, con un coeficiente de determinación del 74%. Los estímulos contextuales influyeron en la adaptación fisiológica y psicosocial, F (6,193 = 2,89, p = ,010, y F (6, 193 = 2,41, p = ,029. Conclusiones. Los resultados de este estudio permiten sugerir relaciones entre las proposiciones teóricas propuestas y derivadas del Modelo de Adaptación de Roy, particularmente entre los estímulos y la adaptación fisiológica y psicosocial en pacientes con diabetes Mellitus Tipo 2.

  16. Problemas adaptativos segundo Roy e diagnósticos fundamentados na CIPE® em hipertensos com doenças associadas

    Directory of Open Access Journals (Sweden)

    Denizielle de Jesus Moreira Moura

    2013-06-01

    Full Text Available O objetivo do presente estudo foi identificar os problemas adaptativos e estímulos fundamentados no modelo teórico de Roy, bem como os diagnósticos de enfermagem segundo a CIPE® Versão 1. Estudo de casos múltiplos, realizado com 45 hipertensos com doenças associadas assistidos em uma unidade de saúde da Secretaria Executiva Regional V - Fortaleza. Dentre os problemas adaptativos identificados o sedentarismo é o mais presente (84,4% dos indivíduos, seguido de sobrepeso/obesidade (57,8% e distúrbios no padrão de sono (42,2%. 64,3% dos diagnósticos de enfermagem identificados encontram-se no âmbito biológico, sendo os de maior prevalência: Autocuidado Parcial (93,3%, Padrão de Exercício Diminuído (84,4%, Dentição Comprometida (82,2%, Aprendizagem Baixa (60,0%, Sobrepeso/Obesidade (57,7%. Concluiu-se que a identificação de problemas adaptativos auxiliam-nos na elaboração de diagnósticos, os quais, por sua vez, conferem uma linguagem própria à enfermagem além de maior autonomia profissional e qualidade na assistência.

  17. Roy-Steiner equations for {pi}N scattering - The Muskhelishvili-Omnes problem for the t-channel partial waves

    Energy Technology Data Exchange (ETDEWEB)

    Ditsche, Christoph; Hoferichter, Martin; Kubis, Bastian [Helmholtz-Institut fuer Strahlen- und Kernphysik (Theorie), Universitaet Bonn (Germany); Bethe Center for Theoretical Physics, Bonn (Germany); Meissner, Ulf G. [Helmholtz-Institut fuer Strahlen- und Kernphysik (Theorie), Universitaet Bonn (Germany); Institut fuer Kernphysik (Theorie), Institute for Advanced Simulations, and Juelich Center for Hadron Physics, Forschungszentrum Juelich, D-52425 Juelich (Germany); Bethe Center for Theoretical Physics, Bonn (Germany)

    2011-07-01

    Starting from (subtracted) hyperbolic dispersion relations for {pi}N scattering, which are based on the general principles of Lorentz invariance, unitarity, crossing and analyticity as well as isospin symmetry, we propose a closed system of (subtracted) hyperbolic partial wave dispersion relations for the partial waves f{sup I}{sub l{+-}}({radical}(s)) of the s-channel reaction {pi}N{yields}{pi}N and the partial waves f{sup J}{sub {+-}}(t) of the t-channel reaction {pi}{pi}{yields} anti NN in the spirit of Roy and Steiner. A key step to the ultimate goal of solving this Roy-Steiner system is to first solve the corresponding (subtracted) Muskhelishvili-Omnes problem with inelasticities and a finite matching point for the lowest t-channel partial waves f{sup 0}{sub +}(t), f{sup 1}{sub {+-}}(t). The recent status of this ongoing effort is presented.

  18. Effect of Roy's Adaptation Model-Guided Education on Coping Strategies of the Veterans with Lower Extremities Amputation: A Double-Blind Randomized Controlled Clinical Trial.

    Science.gov (United States)

    Farsi, Zahra; Azarmi, Somayeh

    2016-04-01

    Any defect in the extremities of the body can affect different life aspects. The purpose of this study was to investigate the effect of Roy's adaptation model-guided education on coping strategies of the veterans with lower extremities amputation. In a double-blind randomized controlled clinical trial, 60 veterans with lower extremities amputation referring to Kowsar Orthotics and Prosthetics Center of Veterans Clinic in Tehran, Iran were recruited using convenience method and randomly assigned to intervention and control groups in 2013-2014. Lazarus and Folkman coping strategies questionnaire was used to collect the data. After completing the questionnaires in both groups, maladaptive behaviours were determined in the intervention group and an education program based on Roy's adaptation model was implemented. After 2 months, both groups completed the questionnaires again. Data were analyzed using SPSS software. Independent T-test showed that the score of the dimensions of coping strategies did not have a statistically significant difference between the intervention and control groups in the pre-intervention stage (P>0.05). This test showed a statistically significant difference between the two groups in the post-intervention stage in terms of the scores of different dimensions of coping strategies (P>0.05), except in dimensions of social support seeking and positive appraisal (P>0.05). The findings of this research indicated that the Roy's adaptation model-guided education improved the majority of coping strategies in veterans with lower extremities amputation. It is recommended that further interventions based on Roy's adaptation model should be performed to improve the coping of the veterans with lower extremities amputation. IRCT2014081118763N1.

  19. Is There a Concordance Between the Gleason Scores of Needle Biopsy and Radical Prostatectomy Specimens in Prostatic Carsinoma?

    Directory of Open Access Journals (Sweden)

    Faruk Özgör

    2016-03-01

    Full Text Available Aim: To evaluate the concordance between the Gleason Scores (GS of prostate biopsy and radical prostatectomy specimens. Methods: Prostate biopsy was performed in 1135 patients with the suspicion of prostate cancer in our clinic between 2008 and 2012. A total of 366 patients were diagnosed with prostate cancer. Radical prostatectomy was performed in 73 of these patients and GS of pathology specimens were included in this study for comparison. The patients were divided into three groups (low intermediate- and high-risk patients according to the D’amico risk classification for prostate cancer. Results: The median age of the patients was 64.2±6.1 years (54- 73. The mean prostate specific antigen level was 20.34 ng/mL and the mean biopsy core number was 12±0.58. A statistically significant concordance was detected between the GS of biopsy specimens and radical prostatectomy materials in 65.7% of patients (p<0.01. There were 40 patients in the low-risk group, however, 8 (20% of them were identified to be intermediate-risk patients and one (2.5% was found to be a high-risk patient after radical prostatectomy. Conclusion: Concordance between the GS of prostate biopsy and radical prostatectomy materials are important for selection of the appropriate treatment

  20. Diagnósticos de enfermagem e modelo adaptativo de Roy: análise em pacientes críticos

    Directory of Open Access Journals (Sweden)

    Anna Lívia de Medeiros Dantas

    2017-01-01

    Full Text Available Objetivo: establecer relación de los diagnósticos de enfermería presentes en el dominio seguridad y protección de NANDA Internacional con los problemas adaptativos del modelo de Roy para pacientes en unidad de cuidados intensivos (UCI. Métodos: estudio transversal, llevado a cabo en la UCI de un hospital universitario en una capital del noreste brasileño. La muestra fue de 86 individuos. Los datos, recolectados entre octubre del 2013 y mayo del 2014, mediante formato de entrevista y prueba física, se analizaron por medio de estadística descriptiva e inferencial. Resultados: entre los diagnósticos de enfermería del dominio seguridad y protección, 29 estuvieron presentes con frecuencias variables. En cuanto a los relacionados con los problemas adaptativos propuestos por Roy, se evidenciaron 12 problemas adaptativos en cuanto al modo adaptativo fisiológico, que abarca las categorías de sentidos, protección, oxigenación, actividad y reposo y nutrición. Conclusiones: se encontró relación entre los diagnósticos de enfermería del dominio seguridad y protección y los problemas adaptativos del modelo de Roy para pacientes en cuidados intensivos.

  1. A Multi-Center Prospective Study to Validate an Algorithm Using Urine and Plasma Biomarkers for Predicting Gleason ≥3+4 Prostate Cancer on Biopsy

    DEFF Research Database (Denmark)

    Albitar, Maher; Ma, Wanlong; Lund, Lars

    2017-01-01

    a prospective multicenter study recruiting patients from community-based practices. Patients and Methods: Urine and plasma samples from 2528 men were tested prospectively. Results were correlated with biopsy findings, if a biopsy was performed as deemed necessary by the practicing urologist. Of the 2528......Background: Unnecessary biopsies and overdiagnosis of prostate cancer (PCa) remain a serious healthcare problem. We have previously shown that urine- and plasma-based prostate-specific biomarkers when combined can predict high grade prostate cancer (PCa). To further validate this test, we performed...... of high grade prostate cancer with negative predictive value (NPV) of 90% to 97% for Gleason ≥3+4 and between 98% to 99% for Gleason ≥4+3....

  2. Nuclear morphometry in histological specimens of canine prostate cancer: Correlation with histological subtypes, Gleason score, methods of collection and survival time.

    Science.gov (United States)

    Di Donato, Guido; Laufer-Amorim, Renée; Palmieri, Chiara

    2017-10-01

    Ten normal prostates, 22 benign prostatic hyperplasia (BPH) and 29 prostate cancer (PC) were morphometrically analyzed with regard to mean nuclear area (MNA), mean nuclear perimeter (MNP), mean nuclear diameter (MND), coefficient of variation of the nuclear area (NACV), mean nuclear diameter maximum (MDx), mean nuclear diameter minimum (MDm), mean nuclear form ellipse (MNFe) and form factor (FF). The relationship between nuclear morphometric parameters and histological type, Gleason score, methods of sample collection, presence of metastases and survival time of canine PC were also investigated. Overall, nuclei from neoplastic cells were larger, with greater variation in nuclear size and shape compared to normal and hyperplastic cells. Significant differences were found between more (small acinar/ductal) and less (cribriform, solid) differentiated PCs with regard to FF (pnuclear morphometric analysis in combination with Gleason score can help in canine prostate cancer grading, thus contributing to the establishment of a more precise prognosis and patient's management. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. The proportion of prostate biopsy tissue with Gleason pattern 4 or 5 predicts for biochemical and clinical outcome after radiotherapy for prostate cancer

    International Nuclear Information System (INIS)

    D'Ambrosio, David J.; Hanlon, Alexandra L.; Al-Saleem, Tahseen; Feigenberg, Steven J.; Horwitz, Eric M.; Uzzo, Robert G.; Pollack, Alan; Buyyounouski, Mark K.

    2007-01-01

    Purpose: To investigate the prognostic utility of the proportion of prostate biopsy tissue containing Gleason pattern 4 or 5 (GP4/5) after definitive radiotherapy (RT) for prostate cancer. Methods and Materials: A total of 568 patients with T1c-3 Nx/0 prostate cancer who received three-dimensional conformal RT alone between May 1989 and August 2001 were studied. There were 161 men with Gleason score 7-10 disease. The GP4/5 was defined as the percentage of biopsy tissue containing Gleason pattern 4 or 5. A Cox proportional hazards model was used for univariate and multivariate analyses (MVA) for biochemical failure (BF) (American Society of Therapeutic Radiology and Oncology definition) and distant metastasis (DM). A recursive partitioning analysis was done using the results of the MVA to identify a cutpoint for GP4/5. Results: The median follow-up was 46 (range, 13-114) months and median RT dose was 76 (range, 65-82) Gy. On MVA, increasing initial prostate-specific antigen (p = 0.0248) decreasing RT dose (continuous, p = 0.0022), T stage (T1/2 vs. T3) (p = 0.0136) and GP4/5 (continuous, p < 0.0001) were significant predictors of BF in a model also containing GS. GP4/5 was the only significant predictor of DM in the same model (p < 0.0001). Conclusion: The GP4/5 in prostate biopsy specimens is a predictor of BF and DM after RT independent of Gleason score. This parameter should be reported by the pathologist when reviewing prostatic biopsy specimens

  4. Inter-observer reproducibility before and after web-based education in the Gleason grading of the prostate adenocarcinoma among the Iranian pathologists.

    Directory of Open Access Journals (Sweden)

    Alireza Abdollahi

    2014-05-01

    Full Text Available This study was aimed at determining intra and inter-observer concordance rates in the Gleason scoring of prostatic adenocarcinoma, before and after a web-based educational course. In this self-controlled study, 150 tissue samples of prostatic adenocarcinoma are re-examined to be scored according to the Gleason scoring system. Then all pathologists attend a free web-based course. Afterwards, the same 150 samples [with different codes compared to the previous ones] are distributed differently among the pathologists to be assigned Gleason scores. After gathering the data, the concordance rate in the first and second reports of pathologists is determined. In the pre web-education, the mean kappa value of Interobserver agreement was 0.25 [fair agreement]. Post web-education significantly improved with the mean kappa value of 0.52 [moderate agreement]. Using weighted kappa values, significant improvement was observed in inter-observer agreement in higher scores of Gleason grade; Score 10 was achieved for the mean kappa value in post web-education was 0.68 [substantial agreement] compared to 0.25 (fair agreement in pre web-education. Web-based training courses are attractive to pathologists as they do not need to spend much time and money. Therefore, such training courses are strongly recommended for significant pathological issues including the grading of the prostate adenocarcinoma. Through web-based education, pathologists can exchange views and contribute to the rise in the level of reproducibility. Such programs need to be included in post-graduation programs.

  5. Can delayed time to referral to a tertiary level urologist with an abnormal PSA level affect subsequent Gleason grade in the opportunistically screened population?

    LENUS (Irish Health Repository)

    O'Kelly, Fardod

    2013-09-01

    There is growing conflict in the literature describing the effect of delayed treatment on outcomes following radical prostatectomy. There is also evidence to suggest progression of low-risk prostate cancer to develop higher grades and volumes of prostate cancer during active surveillance. It is unknown as to what affect a delay in referral of those men with abnormal screened-PSA levels have on subsequent Gleason grade.

  6. Upgrading and downgrading of prostate cancer from biopsy to radical prostatectomy: incidence and predictive factors using the modified Gleason grading system and factoring in tertiary grades.

    Science.gov (United States)

    Epstein, Jonathan I; Feng, Zhaoyong; Trock, Bruce J; Pierorazio, Phillip M

    2012-05-01

    Prior studies assessing the correlation of Gleason score (GS) at needle biopsy and corresponding radical prostatectomy (RP) predated the use of the modified Gleason scoring system and did not factor in tertiary grade patterns. To assess the relation of biopsy and RP grade in the largest study to date. A total of 7643 totally embedded RP and corresponding needle biopsies (2004-2010) were analyzed according to the updated Gleason system. All patients underwent prostate biopsy prior to RP. The relation of upgrading or downgrading to patient and cancer characteristics was compared using the chi-square test, Student t test, and multivariable logistic regression. A total of 36.3% of cases were upgraded from a needle biopsy GS 5-6 to a higher grade at RP (11.2% with GS 6 plus tertiary). Half of the cases had matching GS 3+4=7 at biopsy and RP with an approximately equal number of cases downgraded and upgraded at RP. With biopsy GS 4+3=7, RP GS was almost equally 3+4=7 and 4+3=7. Biopsy GS 8 led to an almost equal distribution between RP GS 4+3=7, 8, and 9-10. A total of 58% of the cases had matching GS 9-10 at biopsy and RP. In multivariable analysis, increasing age (pfactoring in multiple variables including the number of positive cores and the maximum percentage of cancer per core, the concordance indexes were not sufficiently high to justify the use of nomograms for predicting upgrading and downgrading for the individual patient. Almost 20% of RP cases have tertiary patterns. A needle biopsy can sample a tertiary higher Gleason pattern in the RP, which is then not recorded in the standard GS reporting, resulting in an apparent overgrading on the needle biopsy. Copyright © 2012 European Association of Urology. Published by Elsevier B.V. All rights reserved.

  7. Método canguru: práticas investigativas e de cuidado de enfermagem no modelo de adaptação de Roy Método canguro: prácticas de investigación y de atención en enfermería en el modelo de adaptación de Roy Kangaroo method: investigative practices and nursing care in the Roy adaptation model

    Directory of Open Access Journals (Sweden)

    Márcia Borck

    2012-06-01

    Full Text Available Trata-se de uma pesquisa convergente-assistencial, de natureza qualitativa, que teve como objetivos: investigar a experiência no processo de adaptação de seis famílias na terceira etapa do Método Canguru com recém-nascidos pré-termo e/ou de baixo peso, no período de outubro/06 a fevereiro/07; e implementar a consulta de enfermagem dentro dos quatro modos adaptativos da Teoria de Roy. A coleta de dados foi realizada através do processo de cuidar do modelo adaptativo de Roy, utilizando as técnicas de observação e da entrevista semiestruturada. O processo de análise ocorreu por meio da apreensão, síntese, teorização e transferência. Os resultados mostram a necessidade de fortalecer o papel da família na desospitalização e a comunicação entre a equipe interdisciplinar e rever critérios de alta da terceira etapa. Este estudo evidencia a terceira etapa como oportunidade para retroalimentar o sistema de cuidado e apoiar as famílias para sobreporem seus conflitos, preocupações, medos, inseguranças e o próprio comportamento imaturo do bebê.Se trata de una Investigación Convergente y Asistencial, cualitativa. Sus objetivos fueron investigar la experiencia en el proceso de adaptación de seis familias en la tercera etapa del Método Canguro con recién nacidos pre término y/o de bajo peso, en el periodo de Octubre /06 a Febrero /07 e implementar la consulta de enfermería dentro de los cuatro modos adaptativos de la Teoría de Roy. La recolección de los datos fue realizada a través del proceso de cuidar del modelo adaptativo de Roy, utilizando las técnicas de observación y la entrevista parcialmente estructurada. El proceso de análisis se hizo por medio de la aprehensión, síntesis, teorización y transferencia. Los resultados muestran la necesidad de fortalecer el papel de la familia en la deshospitalización, la comunicación entre el equipo disciplinario y rever criterios de alta de la tercera etapa. En este estudio

  8. Componentes do modelo teórico de Roy em pacientes submetidos à hemodiálise

    Directory of Open Access Journals (Sweden)

    Cecília Maria Farias de Queiroz Frazão

    Full Text Available Estudo transversal, objetivando identificar os componentes do modelo teórico de Roy em pacientes submetidos à hemodiálise em um centro de diálise. Participaram 178 pacientes de um centro dialítico no Nordeste do Brasil. A coleta de dados ocorreu de outubro/2011 a fevereiro/2012, por entrevista e exame físico. Os componentes identificados foram: problemas adaptativos, comportamentos e estímulos. Os principais problemas adaptativos foram: retenção de líquido intracelular, hipercalemia, hipotermia, edema, intolerância à atividade. Os comportamentos foram: anúria, desequilíbrio hidroeletrolítico, aumento de peso em curto período, aumento do potássio sérico, temperatura corporal abaixo de 36°C, retenção de líquidos, fadiga, dificuldade em realizar atividades de vida diária. Os estímulos foram: lesão renal, circulação extracorpórea, hemodiálise, não seguimento da restrição hídrica, distúrbio eletrolítico, ambiente frio, efeitos adversos relacionados ao tratamento. Conclui-se que a identificação desses componentes, enquadrados no modo fisiológico, contribui para o planejamento de intervenções de enfermagem específicas e voltadas para a adaptação da clientela.

  9. A highly active endo-levanase BT1760 of a dominant mammalian gut commensal Bacteroides thetaiotaomicron cleaves not only various bacterial levans, but also levan of timothy grass

    DEFF Research Database (Denmark)

    Mardo, Karin; Visnapuu, Triinu; Vija, Heiki

    2017-01-01

    of Pseudomonas syringae pv. tomato, its mutant Asp300Asn, levansucrases of Zymomonas mobilis, Erwinia herbicola, Halomonas smyrnensis as well as on levan isolated from timothy grass. For the first time a plant levan is shown as a perfect substrate for an endo-fructanase of a human gut bacterium. BT1760 degraded...... levans to FOS with degree of polymerization from 2 to 13. At optimal reaction conditions up to 1 g of FOS were produced per 1 mg of BT1760 protein. Low molecular weight (grass levan and levan synthesized from sucrose by the Lsc3Asp300Asn, were degraded most rapidly...... whilst levan produced by Lsc3 from raffinose least rapidly. BT1760 catalyzed finely at human body temperature (37°C) and in moderately acidic environment (pH 5-6) that is typical for the gut lumen. According to differential scanning fluorimetry, the Tm of the endo-levanase was 51.5°C. All tested levans...

  10. ‘The woman was deceived and became a sinner’ – a literary-theological investigation of 1 Timothy 2:11–15

    Directory of Open Access Journals (Sweden)

    Abiola I. Mbamalu

    2014-07-01

    Full Text Available In 1 Timothy 2:11–15 women are forbidden to teach and have authority over men in the church. The ground for this instruction is the creation account in Genesis 2 that asserts the priority of Adam over Eve in the order of creation. The second reason for the instruction is the deception of Eve according to the account of the Fall in Genesis 3. This pericope has elicited arguments between advocates of egalitarianism and complementarianism revolving over the issues of grammar, the context of the Ephesian church with regard to false teachings and the comparison of this text with the other writings of Paul, for those that subscribe to the authorship of Paul. The contention of this article is that verse 15 provides a major clue as to how this text should be understood. In addition, the author’s rhetoric in this text is interrogated with regard to the text’s own internal literary and theological logic. In this regard, the author is found to be inconsistent in his outlook, for the grace that was poured out abundantly on him: a blasphemer, a persecutor and a violent man and on account of his ignorance andunbelief (1 Tm 1:12–16 is apparently, being denied women on account of Eve’s deception.

  11. Ettevaatust, kaitsepolitsei! / Roy Strider

    Index Scriptorium Estoniae

    Strider, Roy, 1974-

    2007-01-01

    Ajendatuna anarhistliku liikumise PunaMust meeleavalduse jälgimisest end ajakirjanikuks nimetanud kaitsepolitsei töötaja poolt kirjutab autor kaitsepolitsei mõttetust nuhkimisest oma kodanike järele, mis võib viia jälgimisühiskonnani

  12. Turvalisuse nimel? / Roy Strider

    Index Scriptorium Estoniae

    Strider, Roy, 1974-

    2008-01-01

    Autor peab silmas hiljuti avalikustatud plaani anda politseile vabamad käed tänavarahutuste mahasurumisel ja inimeste mobiilikõnede eristuste tegemisel ning kirjutab, et ta kardab seda riiki, kus valitseb totaalne infokogumine

  13. The role of strength anisotropy in the development of deep-seated gravitational slope deformation features in schist at Roys Peak, South Island, New Zealand

    Science.gov (United States)

    Brideau, M.

    2013-12-01

    This study looked at the interaction between the rock strength anisotropy and discontinuity orientations on the development of well-expressed deep-seated gravitational slope deformation (DSGSD) features around Roys Peak. The project area is located near the town of Wanaka in the Otago region of New Zealand's South Island. The Roys Peak area has well defined geomorphological features (antislope scarps and split ridges) typically associated with DSGSD over a distance extending almost 4.5 km along the Lake Wanaka Valley. The summit corresponds with the intersection of two prominent ridges running approximately north-south and east-west and has an elevation of 1580 metres above sea level with a local relief of 1250 m. The bedrock geology at Roys Peak consists of Late Paleozoic to Mid Mesozoic pelitic schist having a granitic protolith. The study area has been glaciated several times during the Quaternary Period. Glaciers have strongly influenced the landscape by rounding the spurs in the valley bottom and steepening the lower parts of mountains. Roys Peak is located approximately 75km south from the Alpine Fault (boundary between the Pacific and Australian plates) and as such the project area is not particularly seismically active with only 52 earthquakes with a magnitude greater than 4 within a 50km radius of the project area listed in the New Zealand Historical Earthquake Database. Engineering geological mapping at Roys Peak identified three discontinuity sets and a pervasive schistose fabric in a dip-slope position with the main valley orientation. The rock mass quality was described in the field using the Geological Strength Index (GSI). The observed rock mass quality at Roys Peak had a GSI range between 30-45. This corresponds to a blocky/disturbed/seamy structure with fair quality discontinuity surfaces. The intact rock strength of the schist rock was evaluated using field estimates, Schmidt hammer rebound values, and point load tests. The three methods overlap

  14. EFECTIVIDAD DEL PROGRAMA EDUCATIVO: “ADOPTANDO UNA DIETA SALUDABLE” BASADA EN ROY EN PREESCOLARES DE LA INSTITUCIÓN EDUCATIVA: “UN NUEVO MUNDO”. PIMENTEL- 2014

    OpenAIRE

    Chirinos Fernández, Jennifer Melissa; Universidad Señor de Sipán; Rodríguez Cabrejos, Iris Janet; Universidad Señor de Sípán

    2015-01-01

     El estudio de tipo cuantitativo tuvo como objetivo determinar la efectividad del programa educativo: Adoptando una dieta saludable basada en Callista Roy en preescolares de la I.E. Un nuevo mundo. El diseño fue cuasi experimental. La población fue no probabilística siendo 60 personas, la muestra fue a conveniencia, distribuyéndose en 2 grupos de 20 preescolares, control y experimental respectivamente. El instrumento utilizado fue el Cuestionario de Valoración Nutricional por dimensiones segú...

  15. Imaging primary prostate cancer with 11C-Choline PET/CT: relation to tumour stage, Gleason score and biomarkers of biologic aggressiveness

    International Nuclear Information System (INIS)

    Chen, Ji; Zhao, Yong; Li, Xin; Sun, Peng; Wang, Muwen; Wang, Ridong; Jin, Xunbo

    2012-01-01

    As a significant overlap of 11C-Choline standardized uptake value (SUV) between prostate cancer and benign prostate hyperplasia (BPH) tissue, controversy exists regarding the clinical value of 11C-Choline PET/CT scan in primary prostate cancer. In this study, the SUVmax of the prostate lesions and the pelvic muscles were measured and their ratios (SUVmax-P/M ratio) were calculated. Then we evaluated whether the tracer 11C-Choline uptake, quantified as SUVmax-P/M ratio, correlated with tumour stage, Gleason score, and expression levels of several biomarkers of aggressiveness. Twenty-six patients with primary prostate cancer underwent 11C-Choline PET/CT. Tumour specimens from these patients were graded histopathologically, and immunnohistochemistry for Ki-67, CD31, androgen receptor (AR), Her-2/neu, Bcl-2, and PTEN were performed. Both SUVmax and SUVmax-P/M ratio showed no significant difference between patients with tumour stage II and III, but significantly elevated in patients with tumour stage IV. SUVmax-P/M ratio was also significantly higher in lesions with Gleason score of 4+3 or higher versus less than or equal to 3+4. SUVmax-P/M ratio was found significantly correlated with expression levels of Ki-67 and CD31. In addition, a higher SUVmax-P/M ratio was demonstrated in Her-2/neu positive subgroup than negative subgroup. At the same time, Gleason score and expression levels of these biomarkers showed no significant association with SUVmax. Using the parameter SUVmax-P/M ratio, 11C-Choline PET/CT may be a valuable non-invasive imaging technology in the diagnosis of primary prostate cancer

  16. Comparative study of transgenic Brachypodium distachyon expressing sucrose:fructan 6-fructosyltransferases from wheat and timothy grass with different enzymatic properties.

    Science.gov (United States)

    Tamura, Ken-Ichi; Sanada, Yasuharu; Tase, Kazuhiro; Kawakami, Akira; Yoshida, Midori; Yamada, Toshihiko

    2014-04-01

    Fructans can act as cryoprotectants and contribute to freezing tolerance in plant species, such as in members of the grass subfamily Pooideae that includes Triticeae species and forage grasses. To elucidate the relationship of freezing tolerance, carbohydrate composition and degree of polymerization (DP) of fructans, we generated transgenic plants in the model grass species Brachypodium distachyon that expressed cDNAs for sucrose:fructan 6-fructosyltransferases (6-SFTs) with different enzymatic properties: one cDNA encoded PpFT1 from timothy grass (Phleum pratense), an enzyme that produces high-DP levans; a second cDNA encoded wft1 from wheat (Triticum aestivum), an enzyme that produces low-DP levans. Transgenic lines expressing PpFT1 and wft1 showed retarded growth; this effect was particularly notable in the PpFT1 transgenic lines. When grown at 22 °C, both types of transgenic line showed little or no accumulation of fructans. However, after a cold treatment, wft1 transgenic plants accumulated fructans with DP = 3-40, whereas PpFT1 transgenic plants accumulated fructans with higher DPs (20 to the separation limit). The different compositions of the accumulated fructans in the two types of transgenic line were correlated with the differences in the enzymatic properties of the overexpressed 6-SFTs. Transgenic lines expressing PpFT1 accumulated greater amounts of mono- and disaccharides than wild type and wft1 expressing lines. Examination of leaf blades showed that after cold acclimation, PpFT1 overexpression increased tolerance to freezing; by contrast, the freezing tolerance of the wft1 expressing lines was the same as that of wild type plants. These results provide new insights into the relationship of the composition of water-soluble carbohydrates and the DP of fructans to freezing tolerance in plants.

  17. ANALYSIS ON THE TRANSLATION OF WORDPLAYS IN “THE GOD OF SMALL THINGS” BY ARUNDHATI ROY (Studies on the Wordplay Shifts and the Translation Quality

    Directory of Open Access Journals (Sweden)

    Nur Saptaningsih

    2017-04-01

    Full Text Available Wordplay commonly appears in literary works to enrich the works themselves with certain effect and nuance, either to make a joke or to conceal anything taboo. However, problems frequently occur in translation of wordplay and this becomes an obstacle for a translator to find proper equivalent. Moreover, the translation of wordplay is closely related to different language systems (source and target languages. Novel of ―The God of Small Things‖ by Arundhati Roy is rich in the use of wordplays, but there are a number of shifts found in the translated version of the wordplays. This paper deals with descriptivequalitative research aiming at investigating the shifts of wordplays in the novel of ―The God of Small Things‖ by Arundhati Roy and in the translated version. This study also highlights the contribution of the shifts on the translation quality, in terms of accuracy and acceptability. This product-oriented study applies embedded-case method. The first data for this research are documents, consisting of source text and the translated text. The other data are obtained from informants (raters and respondents, consisting of information dealing with accuracy and acceptability. The data are collected using document analyses, questionnaire, and interview. Purposive sampling and content analysis are applied.

  18. Is it time to retire the A.V. Hill Model?: A rebuttal to the article by Professor Roy Shephard.

    Science.gov (United States)

    Noakes, Timothy D

    2011-04-01

    Recent publications by Emeritus Professor Roy Shephard propose that a "small group of investigators who have argued repeatedly (over the past 13 years) for a 'Central Governor'," should now either "Put up or shut up." Failing this, their 'hypothesis' should be 'consigned to the bottom draw for future reference'; but Professor Shephard's arguments are contradictory. Thus, in different sections of his article, Professor Shephard explains: why there is no need for a brain to regulate exercise performance; why there is no proof that the brain regulates exercise performance; and why the brain's proven role in the regulation of exercise performance is already so well established that additional comment and research is unnecessary. Hence, "The higher centres of an endurance athlete … call forth an initial effort … at a level where a minimal accumulation of lactate in the peripheral muscles is sensed." Furthermore, "a variety of standard texts have illustrated the many mutually redundant feedback loops (to the nervous system) that limit exercise." Yet, the figure from Professor Shephard's 1982 textbook does not contain any links between the nervous system, "many mutually redundant feedback loops" and skeletal muscle. This disproves his contradictory claims that although there is neither any need for, nor any proof of, any role of the brain in the regulation of exercise performance, the physiological mechanisms for this (non-existent) control were already well established in 1982. In contrast, the Central Governor Model (CGM) developed by our "small group … in a single laboratory" after 1998, provides a simple and unique explanation of how 'redundant feedback loops' can assist in the regulation of exercise behaviour. In this rebuttal to his article, I identify (i) the numerous contradictions included in Professor Shephard's argument; (ii) the real meaning of the facts that he presents; (iii) the importance of the evidence that he ignores; and (iv) the different

  19. Gleason Pattern 5 Is the Greatest Risk Factor for Clinical Failure and Death From Prostate Cancer After Dose-Escalated Radiation Therapy and Hormonal Ablation

    Energy Technology Data Exchange (ETDEWEB)

    Sabolch, Aaron [University of Michigan Medical School, Ann Arbor, MI (United States); Feng, Felix Y. [University of Michigan Medical School, Ann Arbor, MI (United States); Department of Radiation Oncology, Ann Arbor, MI (United States); Veterans Administration Medical Center, Ann Arbor, MI (United States); Daignault-Newton, Stephanie [University of Michigan Medical School, Ann Arbor, MI (United States); Division of Biostatistics, Ann Arbor, MI (United States); Halverson, Schuyler; Blas, Kevin; Phelps, Laura [University of Michigan Medical School, Ann Arbor, MI (United States); Olson, Karin B. [University of Michigan Medical School, Ann Arbor, MI (United States); Department of Radiation Oncology, Ann Arbor, MI (United States); Sandler, Howard M. [Department of Radiation Oncology, Cedars Sinai Medical Center, Los Angeles, CA (United States); Hamstra, Daniel A., E-mail: dhamm@med.umich.edu [Department of Radiation Oncology, Ann Arbor, MI (United States)

    2011-11-15

    Purpose: The division of Gleason score (GS) into three categories (2-6, 7, 8-10) may not fully use its prognostic power, as revealed by recent reports demonstrating the presence of Gleason Pattern 5 (GP5) as a strong predictor for biochemical recurrence. Therefore, we analyzed the clinical outcomes in patients treated with dose-escalated radiation therapy (RT) based on the presence or absence of GP5. Methods and Materials: Outcomes were analyzed for 718 men treated for localized prostate cancer with external-beam RT to a minimum planning target volume dose of at least 75 Gy. We assessed the impact of GP5 and that of pretreatment- and treatment-related factors on freedom from biochemical failure, freedom from metastasis (FFM), cause-specific survival (CSS), and overall survival (OS). Results: At biopsy, 89% of patients had no GP5, and 11% (76/718) had GP5. There were no differences in age, comorbid illness, T stage, prostate-specific antigen, or the use or duration of androgen deprivation therapy between GS8 without GP5 and GS8-10 with GP5. The presence of GP5 predicted lower FFM (p < 0.002; hazard ratio [HR] 3.4 [1.7-7.1]); CSS (p < 0.0001; HR 12.9 [5.4-31]); and OS (p < 0.0001; HR 3.6 [2.0-6.5]) in comparison with GS8 (without GP5). The 8-year FFM, CSS, and OS were 89%, 98%, and 57%, respectively, for those with Gleason 8 prostate cancer without GP5 in comparison with 61%, 55%, and 31%, respectively, for those with GP5. In addition, both FFM and CSS were strongly influenced by androgen deprivation therapy given concurrently with RT. On multivariate analysis, GP5 was the strongest prognostic factor for all clinical endpoints, including OS. Conclusion: The presence of GP5 predicts for worse clinical behavior, which therefore needs to be accounted for by risk stratification schemes. Further intensification of local and/or systemic therapy may be appropriate for such patients.

  20. Gleason Pattern 5 Is the Greatest Risk Factor for Clinical Failure and Death From Prostate Cancer After Dose-Escalated Radiation Therapy and Hormonal Ablation

    International Nuclear Information System (INIS)

    Sabolch, Aaron; Feng, Felix Y.; Daignault-Newton, Stephanie; Halverson, Schuyler; Blas, Kevin; Phelps, Laura; Olson, Karin B.; Sandler, Howard M.; Hamstra, Daniel A.

    2011-01-01

    Purpose: The division of Gleason score (GS) into three categories (2–6, 7, 8–10) may not fully use its prognostic power, as revealed by recent reports demonstrating the presence of Gleason Pattern 5 (GP5) as a strong predictor for biochemical recurrence. Therefore, we analyzed the clinical outcomes in patients treated with dose-escalated radiation therapy (RT) based on the presence or absence of GP5. Methods and Materials: Outcomes were analyzed for 718 men treated for localized prostate cancer with external-beam RT to a minimum planning target volume dose of at least 75 Gy. We assessed the impact of GP5 and that of pretreatment- and treatment-related factors on freedom from biochemical failure, freedom from metastasis (FFM), cause-specific survival (CSS), and overall survival (OS). Results: At biopsy, 89% of patients had no GP5, and 11% (76/718) had GP5. There were no differences in age, comorbid illness, T stage, prostate-specific antigen, or the use or duration of androgen deprivation therapy between GS8 without GP5 and GS8–10 with GP5. The presence of GP5 predicted lower FFM (p < 0.002; hazard ratio [HR] 3.4 [1.7–7.1]); CSS (p < 0.0001; HR 12.9 [5.4-31]); and OS (p < 0.0001; HR 3.6 [2.0-6.5]) in comparison with GS8 (without GP5). The 8-year FFM, CSS, and OS were 89%, 98%, and 57%, respectively, for those with Gleason 8 prostate cancer without GP5 in comparison with 61%, 55%, and 31%, respectively, for those with GP5. In addition, both FFM and CSS were strongly influenced by androgen deprivation therapy given concurrently with RT. On multivariate analysis, GP5 was the strongest prognostic factor for all clinical endpoints, including OS. Conclusion: The presence of GP5 predicts for worse clinical behavior, which therefore needs to be accounted for by risk stratification schemes. Further intensification of local and/or systemic therapy may be appropriate for such patients.

  1. Genetics Home Reference: Timothy syndrome

    Science.gov (United States)

    ... 15 [updated 2015 Jul 16]. In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Ledbetter N, Mefford HC, Smith RJH, Stephens K, editors. GeneReviews® [Internet]. Seattle (WA): ...

  2. Aplicación del Modelo de Adaptación de Callista Roy en Latinoamérica: revisión de la literatura

    OpenAIRE

    María Elisa Moreno-Fergusson; Alejandra María Alvarado-García

    2009-01-01

    Con el propósito de conocer los avances en la aplicación del Modelo de Adaptación de Callista Roy en Latinoamérica, se realizó una revisión de la literatura en el período comprendido entre 1996 y 2009. De los 163 documentos encontrados, se seleccionaron 45, que los autores clasificaron en siete categorías, según el propósito de los estudios. Los resultados señalan que el Modelo ha sido aplicado principalmente en Brasil, México y Colombia. La mayoría de los estudios reportados son de tipo desc...

  3. Multiparametric 3T MRI for the prediction of pathological downgrading after radical prostatectomy in patients with biopsy-proven Gleason score 3 + 4 prostate cancer

    International Nuclear Information System (INIS)

    Gondo, Tatsuo; Hricak, Hedvig; Sala, Evis; Vargas, Hebert Alberto; Zheng, Junting; Moskowitz, Chaya S.; Bernstein, Melanie; Eastham, James A.

    2014-01-01

    The aim of this study was to assess the diagnostic performance of pre-treatment 3-Tesla (3T) multiparametric magnetic resonance imaging (mpMRI) for predicting Gleason score (GS) downgrading after radical prostatectomy (RP) in patients with GS 3 + 4 prostate cancer (PCa) on biopsy. We retrospectively reviewed 304 patients with biopsy-proven GS 3 + 4 PCa who underwent mpMRI before RP. On T2-weighted imaging and three mpMRI combinations (T2-weighted imaging + diffusion-weighted imaging [DWI], T2-weighted imaging + dynamic contrast-enhanced-MRI [DCE-MRI], and T2-weighted imaging + DWI + DCE-MRI), two radiologists (R1/R2) scored the presence of a dominant tumour using a 5-point Likert scale (1 = definitely absent to 5 = definitely present). Diagnostic performance in identifying downgrading was evaluated via areas under the curves (AUCs). Predictive accuracies of multivariate models were calculated. In predicting downgrading, T2-weighted imaging + DWI (AUC = 0.89/0.85 for R1/R2) performed significantly better than T2-weighted imaging alone (AUC = 0.72/0.73; p 0.99 for R1/R2). On multivariate analysis, the clinical + mpMRI model incorporating T2-weighted imaging + DWI (AUC = 0.92/0.88 for R1/R2) predicted downgrading significantly better than the clinical model (AUC = 0.73; p < 0.001 for R1/R2). mpMRI improves the ability to identify a subgroup of patients with Gleason 3 + 4 PCa on biopsy who are candidates for active surveillance. DCE-MRI (compared to T2 + DWI) offered no additional benefit to the prediction of downgrading. (orig.)

  4. Multiparametric 3T MRI for the prediction of pathological downgrading after radical prostatectomy in patients with biopsy-proven Gleason score 3 + 4 prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Gondo, Tatsuo [Memorial Sloan-Kettering Cancer Center, Urology Service, Department of Surgery, New York, NY (United States); Tokyo Medical University, Department of Urology, Tokyo (Japan); Hricak, Hedvig; Sala, Evis; Vargas, Hebert Alberto [Memorial Sloan-Kettering Cancer Center, Department of Radiology, New York, NY (United States); Zheng, Junting; Moskowitz, Chaya S. [Memorial Sloan-Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY (United States); Bernstein, Melanie; Eastham, James A. [Memorial Sloan-Kettering Cancer Center, Urology Service, Department of Surgery, New York, NY (United States)

    2014-12-15

    The aim of this study was to assess the diagnostic performance of pre-treatment 3-Tesla (3T) multiparametric magnetic resonance imaging (mpMRI) for predicting Gleason score (GS) downgrading after radical prostatectomy (RP) in patients with GS 3 + 4 prostate cancer (PCa) on biopsy. We retrospectively reviewed 304 patients with biopsy-proven GS 3 + 4 PCa who underwent mpMRI before RP. On T2-weighted imaging and three mpMRI combinations (T2-weighted imaging + diffusion-weighted imaging [DWI], T2-weighted imaging + dynamic contrast-enhanced-MRI [DCE-MRI], and T2-weighted imaging + DWI + DCE-MRI), two radiologists (R1/R2) scored the presence of a dominant tumour using a 5-point Likert scale (1 = definitely absent to 5 = definitely present). Diagnostic performance in identifying downgrading was evaluated via areas under the curves (AUCs). Predictive accuracies of multivariate models were calculated. In predicting downgrading, T2-weighted imaging + DWI (AUC = 0.89/0.85 for R1/R2) performed significantly better than T2-weighted imaging alone (AUC = 0.72/0.73; p < 0.001/p = 0.02 for R1/R2), while T2-weighted imaging + DWI + DCE-MRI (AUC = 0.89/0.84 for R1/R2) performed no better than T2-weighted imaging + DWI (p = 0.48/p > 0.99 for R1/R2). On multivariate analysis, the clinical + mpMRI model incorporating T2-weighted imaging + DWI (AUC = 0.92/0.88 for R1/R2) predicted downgrading significantly better than the clinical model (AUC = 0.73; p < 0.001 for R1/R2). mpMRI improves the ability to identify a subgroup of patients with Gleason 3 + 4 PCa on biopsy who are candidates for active surveillance. DCE-MRI (compared to T2 + DWI) offered no additional benefit to the prediction of downgrading. (orig.)

  5. Bone scan can be spared in asymptomatic prostate cancer patients with PSA of ≤20 ng/ml and gleason score of ≤6 at the initial stage of diagnosis

    International Nuclear Information System (INIS)

    Tanaka, Nobumichi; Fujimoto; Kiyohide; Shinkai, Takayuki

    2011-01-01

    According to several guidelines, it is acceptable to spare a bone scan in the patients who are newly diagnosed with low-risk prostate cancer. Our aim is to clarify a suitable group whereby a bone scan could be spared at the initial staging of prostate cancer. Consecutive 857 patients who were newly diagnosed from 2004 through 2009 and received bone scans using technetium 99m methylene diphosphonate at the initial staging were enrolled. The proportion of positive bone metastases by age distribution, prostate-specific antigen level at diagnosis, Gleason score and clinical T stage were evaluated. Univariate and multivariate logistic regression analyses were performed to identify the predictors of positive bone metastases. Of all 857 patients, 40 patients (4.7%) showed bone metastases. Patients with higher age, prostate-specific antigen level, clinical stage and Gleason score showed significantly higher rate of bone metastases (P 50 ng/ml and the Gleason score ≥4+3 were independent predictors of bone metastases. The incidences of bone metastases in patients with a prostate-specific antigen level of ≤20 ng/ml and Gleason score of ≤6 were reasonably low. Collectively, a bone scan is not necessary as a routine examination for these patients at their initial staging of prostate cancer. (author)

  6. BOOK REVIEW Cracking the Einstein Code: Relativity and the Birth of Black Hole Physics With an Afterword by Roy Kerr Cracking the Einstein Code: Relativity and the Birth of Black Hole Physics With an Afterword by Roy Kerr

    Science.gov (United States)

    Carr, Bernard

    2011-02-01

    General relativity is arguably the most beautiful scientific theory ever conceived but its status within mainstream physics has vacillated since it was proposed in 1915. It began auspiciously with the successful explanation of the precession of Mercury and the dramatic confirmation of light-bending in the 1919 solar eclipse expedition, which turned Einstein into an overnight celebrity. Though little noticed at the time, there was also Karl Schwarzschild's discovery of the spherically symmetric solution in 1916 (later used to predict the existence of black holes) and Alexander Friedmann's discovery of the cosmological solution in 1922 (later confirmed by the discovery of the cosmic expansion). Then for 40 years the theory was more or less forgotten, partly because most physicists were turning their attention to the even more radical developments of quantum theory but also because the equations were too complicated to solve except in situations involving special symmetries or very weak gravitational fields (where general relativity is very similar to Newtonian theory). Furthermore, it was not clear that strong gravitational fields would ever arise in the real universe and, even if they did, it seemed unlikely that Einstein's equations could then be solved. So research in relativity became a quiet backwater as mainstream physics swept forward in other directions. Even Einstein lost interest, turning his attention to the search for a unified field theory. This book tells the remarkable story of how the tide changed in 1963, when the 28-year-old New Zealand mathematician Roy Kerr discovered an exact solution of Einstein's equations which represents a rotating black hole, thereby cracking the code of the title. The paper was just a few pages long, it being left for others to fill in the extensive beautiful mathematics which underlay the result, but it ushered in a golden age of relativity and is now one of the most cited works in physics. Coincidentally, Kerr

  7. Methane production, nutrient digestion, ruminal fermentation, N balance, and milk production of cows fed timothy silage- or alfalfa silage-based diets.

    Science.gov (United States)

    Hassanat, F; Gervais, R; Massé, D I; Petit, H V; Benchaar, C

    2014-10-01

    The objective of this study was to investigate the effects of changing forage source in dairy cow diets from timothy silage (TS) to alfalfa silage (AS) on enteric CH₄ emissions, ruminal fermentation characteristics, digestion, milk production, and N balance. Nine ruminally cannulated lactating cows were used in a replicated 3 × 3 Latin square design (32-d period) and fed (ad libitum) a total mixed ration (TMR; forage:concentrate ratio of 60:40, dry matter basis), with the forage portion consisting of either TS (0% AS; 0% AS and 54.4% TS in the TMR), a 50:50 mixture of both silages (50% AS; 27.2% AS and 27.2% TS in the TMR), or AS (100% AS; 54.4% AS and 0% TS in the TMR). Compared with TS, AS contained less (36.9 vs. 52.1%) neutral detergent fiber but more (20.5 vs. 13.6%) crude protein (CP). In sacco 24-h ruminal degradability of organic matter (OM) was higher for AS than for TS (73.5 vs. 66.9%). Replacement of TS with AS in the diet entailed increasing proportions of corn grain and bypass protein supplement at the expense of soybean meal. As the dietary proportion of AS increased, CP and starch concentrations increased, whereas fiber content declined in the TMR. Dry matter intake increased linearly with increasing AS proportions in the diet. Apparent total-tract digestibility of OM and gross energy remained unaffected, whereas CP digestibility increased linearly and that of fiber decreased linearly with increasing inclusion of AS in the diet. The acetate-to-propionate ratio was not affected, whereas ruminal concentration of ammonia (NH₃) and molar proportion of branched-chain VFA increased as the proportion of AS in the diet increased. Daily CH₄ emissions tended to increase (476, 483, and 491 g/d for cows fed 0% AS, 50% AS, and 100% AS, respectively) linearly as cows were fed increasing proportions of AS. Methane production adjusted for dry matter intake (average=19.8 g/kg) or gross energy intake (average=5.83%) was not affected by increasing AS inclusion

  8. Assistência de enfermagem a idosos que realizam cateterismo cardíaco: uma proposta a partir do modelo de adaptação de Calista Roy Asistencia de enfermería a ancianos que realizan cateterismo cardíaco: una propuesta a partir del modelo de adaptación de Calista Roy Nursing care to elderly patients undergoing heart catheterization: a proposal according to the Adaptation model of Calista Roy

    Directory of Open Access Journals (Sweden)

    Maria Célia de Freitas

    2006-10-01

    Full Text Available O estudo objetivou identificar os diagnósticos de enfermagem de idosos que realizam cateterismo cardíaco, abordando os aspectos psicossociais, segundo a Teoria de Adaptação de Roy. Desenvolveu-se em hospital de pronto-atendimento em cardiologia de Fortaleza-CE, de janeiro a julho de 2005. Utilizou-se entrevista semi-estruturada, com 18 idosos de ambos os sexos, no pré-cateterismo. Na análise reconheceram-se os diagnósticos: alteração na manutenção da saúde, ansiedade, medo e alteração no processo familiar. Como intervenções propõe-se: criar um clima de confiança, antes do exame; escutar e respeitar sentimentos, crenças e valores, orientar quanto ao procedimento. A utilização desta teoria permitiu reconhecer que as pessoas, mediante estímulos, podem desencadear respostas positivas ou negativas, cabendo ao enfermeiro atuar como mediador.El estúdio objetivó identificar los diagnósticos de enfermería abordando los aspectos psico-sociales de los pacientes que realizan cateterismo cardiaco, según la Teoría de Adaptación de Roy. Se desarrolló en la sección de cardiología de un hospital de Fortaleza-CE, de Janeiro a Julio de 2005. Se utilizó la entrevista semi-estructurada, con 18 ancianos, en el pre-cateterismo. En el análisis reconocieron los diagnósticos: alteración en la manutención de la salud, ansiedad, miedo y alteración en el proceso familiar. Entre las acciones se elaboraron las siguientes: crearse un clima de confianza para el paciente después del examen; escuchar y respetar sentimientos, creencias y valores referentes a la situación; orientar el paciente cuanto al procedimiento. La utilización de esta teoría permitió reconocer que las personas, mediante estímulos, pueden desencadenar respuestas ora positivas ora negativas, cabiendo al enfermero actuar como mediador.The study aimed at identifying the nursing diagnoses related to the psychological and social aspects of elderly patients undergoing

  9. Monitoring Soil Erosion of a Burn Site in the Central Basin and Range Ecoregion: Final Report on Measurements at the Gleason Fire Site, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Julianne [DRI; Etyemezian, Vicken [DRI; Shillito, Rose [DRI; Cablk, Mary [DRI; Fenstermaker, Lynn [DRI; Shafer, David [DOE Legacy Management

    2013-10-01

    The increase in wildfires in arid and semi-arid parts of Nevada and elsewhere in the southwestern United States has implications for post-closure management and long-term stewardship for Soil Corrective Action Units (CAUs) on the Nevada National Security Site (NNSS) for which the Nevada Field Office of the United States Department of Energy, National Nuclear Security Administration has responsibility. For many CAUs and Corrective Action Sites, where closure-in-place alternatives are now being implemented or considered, there is a chance that these sites could burn over at some time while they still pose a risk to the environment or human health, given the long half lives of some of the radionuclide contaminants. This study was initiated to examine the effects and duration of wildfire on wind and water erodibility on sites analogous to those that exist on the NNSS. The data analyzed herein were gathered at the prescribed Gleason Fire site near Ely, Nevada, a site comparable to the northern portion of the NNSS. Quantification of wind erosion was conducted with a Portable In-Situ Wind ERosion Lab (PI-SWERL) on unburned soils, and on interspace and plant understory soils within the burned area. The PI-SWERL was used to estimate emissions of suspendible particles (particulate matter with aerodynamic diameters less than or equal to 10 micrometers) at different wind speeds. Filter samples, collected from the exhaust of the PI-SWERL during measurements, were analyzed for chemical composition. Based on nearly three years of data, the Gleason Fire site does not appear to have returned to pre burn wind erosion levels. Chemical composition data of suspendible particles are variable and show a trend toward pre-burn levels, but provide little insight into how the composition has been changing over time since the fire. Soil, runoff, and sediment data were collected from the Gleason Fire site to monitor the water erosion potential over the nearly three-year period. Soil

  10. Clinical Outcomes for Patients with Gleason Score 9-10 Prostate Adenocarcinoma Treated With Radiotherapy or Radical Prostatectomy: A Multi-institutional Comparative Analysis.

    Science.gov (United States)

    Kishan, Amar U; Shaikh, Talha; Wang, Pin-Chieh; Reiter, Robert E; Said, Jonathan; Raghavan, Govind; Nickols, Nicholas G; Aronson, William J; Sadeghi, Ahmad; Kamrava, Mitchell; Demanes, David Jeffrey; Steinberg, Michael L; Horwitz, Eric M; Kupelian, Patrick A; King, Christopher R

    2017-05-01

    The long natural history of prostate cancer (CaP) limits comparisons of efficacy between radical prostatectomy (RP) and external beam radiotherapy (EBRT), since patients treated years ago received treatments considered suboptimal by modern standards (particularly with regards to androgen deprivation therapy [ADT] and radiotherapy dose-escalation]. Gleason score (GS) 9-10 CaP is particularly aggressive, and clinically-relevant endpoints occur early, facilitating meaningful comparisons. To compare outcomes of patients with GS 9-10 CaP following EBRT, extremely-dose escalated radiotherapy (as exemplified by EBRT+brachytherapy [EBRT+BT]), and RP. Retrospective analysis of 487 patients with biopsy GS 9-10 CaP treated between 2000 and 2013 (230 with EBRT, 87 with EBRT+BT, and 170 with RP). Most radiotherapy patients received ADT and dose-escalated radiotherapy. Kaplan-Meier analysis and multivariate Cox regression estimated and compared 5-yr and 10-yr rates of distant metastasis-free survival, cancer-specific survival (CSS), and overall survival (OS). The median follow-up was 4.6 yr. Local salvage and systemic salvage were performed more frequently in RP patients (49.0% and 30.1%) when compared with either EBRT patients (0.9% and 19.7%) or EBRT+BT patients (1.2% and 16.1%, pRadiotherapy and RP provide equivalent CSS and OS. Extremely dose-escalated radiotherapy with ADT in particular offers improved systemic control when compared with either EBRT or RP. These data suggest that extremely dose-escalated radiotherapy with ADT might be the optimal upfront treatment for patients with biopsy GS 9-10 CaP. While some prostate cancers are slow-growing requiring many years, sometimes decades, of follow-up in order to compare between radiation and surgery, high-risk and very aggressive cancers follow a much shorter time course allowing such comparisons to be made and updated as treatments, especially radiation, rapidly evolve. We showed that radiation-based treatments and surgery

  11. Radiation dose response in patients with favorable localized prostate cancer (Stage T1-T2, biopsy Gleason ≤6, and pretreatment prostate-specific antigen ≤10)

    International Nuclear Information System (INIS)

    Kupelian, Patrick A.; Buchsbaum, Jeffrey C.; Reddy, Chandana A.; Klein, Eric A.

    2001-01-01

    Purpose: To study the radiation dose response as determined by biochemical relapse-free survival in patients with favorable localized prostate cancers, i.e., Stage T1-T2, biopsy Gleason score (bGS) ≤6, and pretreatment prostate-specific antigen (iPSA) ≤10 ng/mL. Methods and Materials: A total of 292 patients with favorable localized prostate cancer were treated with radiotherapy alone between 1986 and 1999. The median age was 69 years. Sixteen percent of cases (n=46) were African-American. The distribution by clinical T stage was as follows: T1/T2A, 243 (83%); and T2B/T2C, 49 (17%). The distribution by iPSA was as follows: ≤4 ng/mL, 49 (17%); and >4 ng/mL, 243 (83%). The mean iPSA level was 6.2 (median, 6.4). The distribution by bGS was as follows: ≤5 in 89 cases (30%) and 6 in 203 cases (70%). The median radiation dose was 70.0 Gy (range, 63.0-78.0 Gy). Doses of ≤70.0 Gy were delivered in 175 cases, 70.2-72.0 Gy in 24 cases, 74 Gy in 30 cases, and 78 Gy in 63 cases. For patients receiving 2 =5.7), and radiation dose (p=0.021, χ 2 =5.3) were independent predictors of outcome. Age (p=0.94), race (p=0.89), stage (p=0.45), biopsy GS (p=0.40), and radiation technique (p=0.45) were not. Conclusion: There is a clear radiation dose response in patients with favorable localized prostate cancers (i.e., Stage T1-T2, biopsy Gleason score ≤6, and iPSA ≤10 ng/mL). At least 74 Gy should be delivered to the prostate and periprostatic tissues. With our cohort of patients, longer follow-up will be needed to assess the importance of doses exceeding 74 Gy

  12. Relationships between serum PSA levels, Gleason scores and results of 68Ga-PSMAPET/CT in patients with recurrent prostate cancer.

    Science.gov (United States)

    Sanli, Yasemin; Kuyumcu, Serkan; Sanli, Oner; Buyukkaya, Fikret; İribaş, Ayça; Alcin, Goksel; Darendeliler, Emin; Ozluk, Yasemin; Yildiz, Sevda Ozel; Turkmen, Cüneyt

    2017-11-01

    To investigate the relationship between serum PSA level, Gleason score of PCa and the outcomes of Ga 68 -PSMA PET/CT in patients with recurrent PCa. A total of 109 consecutive patients (median age 71 years; range 48-89 years) who had PSA recurrence after RP and/or hormonotherapy and/or radiotherapy were included in this study. Local recurrences, lymph node metastasis (pelvic, abdominal and/or supradiaphragmatic), bone metastases (oligometastatic/multimetastatic) and other metastatic sites (lung, liver, brain, etc) were documented. In 91(83.4%) patients at least one lesion characteristic for PCa was detected by 68 Ga-PSMA PET/CT. The median serum total PSA (tPSA) was 6.5 (0.2-640) ng/ml.There was a significant difference between 68 Ga-PSMA PET/CT positive and negative patients in terms of serum total PSA value. No statistical significance was found between positive and negative 68 Ga-PSMA PET/CT findings in terms of Gleason score. Local recurrence was detected in 56 patients. whereas lymph node metastases were demonstrated in 46 patients. Pelvic nodal disease was the most frequent presentation followed by abdominal and supradiaphragmaticnodal involvement. Bone metastases [oligometastasis, (n = 20); multimetastasis, (n = 35)⦌ were also detected in 55 patients. In the ROC analysis for the study cohort, the optimal cut-off value of total serum PSA was determined as 0.67 ng/ml for distinguishing between positive and negative 68 Ga-PSMA PET/CT images, with an area under curve of 0.952 (95% CI 0.911-0.993). 68 Ga-PSMA PET/CT was found to be an effective tool for the detection of recurrent PCa. Even though no relationship was detected between the GS and 68 Ga-PSMA PET/CT findings, serum total PSA values may be used for estimating the likelihood of positive 68 Ga-PSMA PET/CT results.

  13. African-American Men with Gleason Score 3+3=6 Prostate Cancer Produce Less Prostate Specific Antigen than Caucasian Men: A Potential Impact on Active Surveillance.

    Science.gov (United States)

    Kryvenko, Oleksandr N; Balise, Raymond; Soodana Prakash, Nachiketh; Epstein, Jonathan I

    2016-02-01

    We assess the difference in prostate specific antigen production between African-American and Caucasian men with Gleason score 3+3=6 prostate cancer. We measured tumor volume in 414 consecutive radical prostatectomies from men with National Comprehensive Cancer Network(®) low risk prostate cancer (348 Caucasian, 66 African-American) who had Gleason score 3+3=6 disease at radical prostatectomy. We then compared clinical presentation, pathological findings, prostate specific antigen, prostate specific antigen density and prostate specific antigen mass (an absolute amount of prostate specific antigen in patient's circulation) between African-American and Caucasian men. The t-test and Wilcoxon rank sum were used for comparison of means. African-American and Caucasian men had similar clinical findings based on age, body mass index and prostate specific antigen. There were no statistically significant differences between the dominant tumor nodule volume and total tumor volume (mean 0.712 vs 0.665 cm(3), p=0.695) between African-American and Caucasian men. Prostates were heavier in African-American men (mean 55.4 vs 46.3 gm, p prostate tissue contributing to prostate specific antigen in African-American men, prostate specific antigen mass was not different from that of Caucasian men (mean 0.55 vs 0.558 μg, p=0.95). Prostate specific antigen density was significantly less in African-American men due to larger prostates (mean 0.09 vs 0.105, p prostate cancer produce less prostate specific antigen than Caucasian men. African-American and Caucasian men had equal serum prostate specific antigen and prostate specific antigen mass despite significantly larger prostates in African-American men with all other parameters, particularly total tumor volume, being the same. This finding has practical implications in T1c cases diagnosed with prostate cancer due to prostate specific antigen screening. Lowering the prostate specific antigen density threshold in African-American men may

  14. Modelo de Adaptação de Roy: revisão integrativa dos estudos realizados à luz da teoria

    Directory of Open Access Journals (Sweden)

    Lays Pinheiro de Medeiros

    2015-01-01

    Full Text Available identificar las evidencias científicas acerca de los componentes del Modelo de Adaptación de Roy en poblaciones estudiadas a la luz de esta teoría. Método: revisión integradora de la literatura en las bases de datos Literatura Latinoamericana y Ciencias de la Salud del Caribe, Medical Literature Analysis and Retrieval System Online, Índice Bibliográfico Español de Ciencias de la Salud, Base de Datos de Enfermería, PubMed Central, Cumulative Index to Nursing and Allied Health Literature, Web Of Science eSciVerse Scopus. La muestra constó de 20 artículos publicados entre años 2005-2013. Resultados: se identificaron tres tipos de estímulos, 38 de los 82 problemas de adaptación, los cuatro modos de adaptación y los seis pasos del proceso de enfermería. Conclusión: hay necesidad de estudios sobre esta teoría que aborden todo el proceso de enfermería, culminándose en aumento de conocimientos específicos de enfermería y afirmación de esta ciencia en salud.

  15. Arundhati Roy, a One-woman Dissident Force against the Instant-Mix Imperial Democracy Arundhati Roy, la force d’une seule femme face à la démocratie impériale prête à l’emploi

    Directory of Open Access Journals (Sweden)

    Geetha Ganapathy-Doré

    2009-10-01

    Full Text Available Mieux connu pour son roman Le Dieu des petits riens qui a ébloui le monde anglophone par son style novateur et choqué les lecteurs indiens en mettant en scène l’amour entre une femme de haute caste et un paria, Arundhati Roy est une écrivaine engagée qui dénonce les dérives pronucléaires et néolibérales du gouvernement indien et mène une lutte contre la mondialisation capitaliste là où elle se manifeste. Les essais polémiques que Roy a écrits après les attentats du 11 septembre s’attaquent de façon virulente à l’impérialisme américain. Elle déconstruit l’Empire en exposant les piliers invisibles de son architecture et en décodant sa rhétorique. Elle en analyse les  présupposés éthiques, les rouages économiques, la pénétration culturelle et les implications juridiques afin de définir les stratégies de résistance pour réaffirmer les valeurs de la dignité humaine, de la justice sociale et de la paix. Dans le projet d’assiéger l’Empire, elle est appuyée par des dissidents célèbres tels que Noam Chomsky, Howard Zinn, Amy Goodman et d’autres.

  16. Insulin-like growth factor II mRNA binding protein 3 (IMP3) is overexpressed in prostate cancer and correlates with higher Gleason scores

    International Nuclear Information System (INIS)

    Ikenberg, Kristian; Behnke, Silvia; Gerhardt, Josefine; Mortezavi, Ashkan; Wild, Peter; Hofstädter, Ferdinand; Burger, Maximilian; Moch, Holger; Kristiansen, Glen; Fritzsche, Florian R; Zuerrer-Haerdi, Ursina; Hofmann, Irina; Hermanns, Thomas; Seifert, Helge; Müntener, Michael; Provenzano, Maurizio; Sulser, Tullio

    2010-01-01

    The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. To our knowledge, IMP3 expression has not been investigated in prostate carcinomas so far. Immunohistochemical stainings for IMP3 were performed on tissue microarray (TMA) organized samples from 507 patients: 31 normal prostate tissues, 425 primary carcinomas and 51 prostate cancer metastases or castration-resistant prostate cancers (CRPC). IMP3 immunoreactivity was semiquantitatively scored and correlated with clinical-pathologic parameters including survival. IMP3 is significantly stronger expressed in prostate carcinomas compared to normal prostate tissues (p < 0.0001), but did not show significant correlation with the pT-stage, the proliferation index (MIB1), preoperative serum PSA level and the margin status. Only a weak and slightly significant correlation was found with the Gleason score and IMP3 expression failed to show prognostic significance in clinico-pathological correlation-analyses. Although IMP3 is overexpressed in a significant proportion of prostate cancer cases, which might be of importance for novel therapeutic approaches, it does not appear to possess any immediate diagnostic or prognostic value, limiting its potential as a tissue biomarker for prostate cancer. These results might be corroborated by the fact, that two independent tumor cohorts were separately reviewed

  17. High serum dihydrotestosterone examined by ultrasensitive LC-MS/MS as a predictor of benign prostatic hyperplasia or Gleason score 6 cancer in men with prostate-specific antigen levels of 3-10 ng/mL.

    Science.gov (United States)

    Miyoshi, Y; Uemura, H; Suzuki, K; Shibata, Y; Honma, S; Harada, M; Kubota, Y

    2017-03-01

    There has been no consensus on the role of serum androgen concentrations in prostate cancer detection in men with prostate-specific antigen levels of 3-10 ng/mL. In this study, testosterone and dihydrotestosterone concentrations in blood were examined by a newly developed method using ultrasensitive liquid chromatography with two serially linked mass spectrometers (LC-MS/MS). We investigated the correlation between serum androgen levels and Gleason scores at biopsy. We analyzed data of 157 men with a total prostate-specific antigen range of 3-10 ng/mL who underwent initial systematic prostate needle biopsy for suspected prostate cancer between April 2000 and July 2003. Peripheral blood testosterone and dihydrotestosterone concentrations were determined by LC-MS/MS. Blood levels of testosterone and dihydrotestosterone were compared with pathological findings by multivariate analyses. Median values of prostate-specific antigen and prostate volume measured by ultrasound were 5.7 ng/mL and 31.4 cm 3 , respectively. Benign prostatic hyperplasia was diagnosed in 97 patients (61.8%), and prostate cancer was diagnosed in 60 (38.2%) patients, including 31 (19.7%) patients with a Gleason score of 6 and 29 (18.5%) patients with a Gleason score of 7-10. Median values of testosterone and dihydrotestosterone in blood were 3798.7 and 371.7 pg/mL, respectively. There was a strong correlation between serum testosterone and dihydrotestosterone. In multivariate analysis, age, prostate volume, and serum dihydrotestosterone were significant predictors of benign prostatic hyperplasia or prostate cancer with a Gleason score of 6. The area under the receiver operating characteristics curve for age, prostate volume, and serum dihydrotestosterone were 0.67, 0.67, and 0.67, respectively . We confirmed that high dihydrotestosterone blood levels can predict benign prostatic hyperplasia or prostate cancer with a Gleason score of 6 in men with prostate-specific antigen levels of 3-10

  18. A 17-gene assay to predict prostate cancer aggressiveness in the context of Gleason grade heterogeneity, tumor multifocality, and biopsy undersampling.

    Science.gov (United States)

    Klein, Eric A; Cooperberg, Matthew R; Magi-Galluzzi, Cristina; Simko, Jeffry P; Falzarano, Sara M; Maddala, Tara; Chan, June M; Li, Jianbo; Cowan, Janet E; Tsiatis, Athanasios C; Cherbavaz, Diana B; Pelham, Robert J; Tenggara-Hunter, Imelda; Baehner, Frederick L; Knezevic, Dejan; Febbo, Phillip G; Shak, Steven; Kattan, Michael W; Lee, Mark; Carroll, Peter R

    2014-09-01

    Prostate tumor heterogeneity and biopsy undersampling pose challenges to accurate, individualized risk assessment for men with localized disease. To identify and validate a biopsy-based gene expression signature that predicts clinical recurrence, prostate cancer (PCa) death, and adverse pathology. Gene expression was quantified by reverse transcription-polymerase chain reaction for three studies-a discovery prostatectomy study (n=441), a biopsy study (n=167), and a prospectively designed, independent clinical validation study (n=395)-testing retrospectively collected needle biopsies from contemporary (1997-2011) patients with low to intermediate clinical risk who were candidates for active surveillance (AS). The main outcome measures defining aggressive PCa were clinical recurrence, PCa death, and adverse pathology at prostatectomy. Cox proportional hazards regression models were used to evaluate the association between gene expression and time to event end points. Results from the prostatectomy and biopsy studies were used to develop and lock a multigene-expression-based signature, called the Genomic Prostate Score (GPS); in the validation study, logistic regression was used to test the association between the GPS and pathologic stage and grade at prostatectomy. Decision-curve analysis and risk profiles were used together with clinical and pathologic characteristics to evaluate clinical utility. Of the 732 candidate genes analyzed, 288 (39%) were found to predict clinical recurrence despite heterogeneity and multifocality, and 198 (27%) were predictive of aggressive disease after adjustment for prostate-specific antigen, Gleason score, and clinical stage. Further analysis identified 17 genes representing multiple biological pathways that were combined into the GPS algorithm. In the validation study, GPS predicted high-grade (odds ratio [OR] per 20 GPS units: 2.3; 95% confidence interval [CI], 1.5-3.7; p<0.001) and high-stage (OR per 20 GPS units: 1.9; 95% CI, 1

  19. Pilot Study of the Use of Hybrid Multidimensional T2-Weighted Imaging-DWI for the Diagnosis of Prostate Cancer and Evaluation of Gleason Score.

    Science.gov (United States)

    Sadinski, Meredith; Karczmar, Gregory; Peng, Yahui; Wang, Shiyang; Jiang, Yulei; Medved, Milica; Yousuf, Ambereen; Antic, Tatjana; Oto, Aytekin

    2016-09-01

    The objective of our study was to evaluate the role of a hybrid T2-weighted imaging-DWI sequence for prostate cancer diagnosis and differentiation of aggressive prostate cancer from nonaggressive prostate cancer. Twenty-one patients with prostate cancer who underwent preoperative 3-T MRI and prostatectomy were included in this study. Patients underwent a hybrid T2-weighted imaging-DWI examination consisting of DW images acquired with TEs of 47, 75, and 100 ms and b values of 0 and 750 s/mm(2). The apparent diffusion coefficient (ADC) and T2 were calculated for cancer and normal prostate ROIs at each TE and b value. Changes in ADC and T2 as a function of increasing the TE and b value, respectively, were analyzed. A new metric termed "PQ4" was defined as the percentage of voxels within an ROI that has increasing T2 with increasing b value and has decreasing ADC with increasing TE. ADC values were significantly higher in normal ROIs than in cancer ROIs at all TEs (p T2 was significantly higher in normal ROIs than in cancer ROIs at both b values (p ≤ 0.0002). The mean T2 decreased with increasing b value in cancer ROIs (ΔT2 = -17 ms) and normal ROIs (ΔT2 = -52 ms). PQ4 clearly differentiated normal ROIs from prostate cancer ROIs (p = 0.0004) and showed significant correlation with Gleason score (ρ = 0.508, p T2 to changing TEs and b values, respectively. This approach shows promise for detecting prostate cancer and determining its aggressiveness noninvasively.

  20. Haralick texture analysis of prostate MRI: utility for differentiating non-cancerous prostate from prostate cancer and differentiating prostate cancers with different Gleason scores

    Energy Technology Data Exchange (ETDEWEB)

    Wibmer, Andreas; Hricak, Hedvig; Sala, Evis; Vargas, Hebert Alberto [Memorial Sloan Kettering Cancer Center, Department of Radiology, New York City, NY (United States); Gondo, Tatsuo; Matsumoto, Kazuhiro; Eastham, James [Memorial Sloan Kettering Cancer Center, Department of Urology, New York City, NY (United States); Veeraraghavan, Harini; Fehr, Duc [Memorial Sloan Kettering Cancer Center, Department of Medical Physics, New York City, NY (United States); Zheng, Junting; Goldman, Debra; Moskowitz, Chaya [Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York City, NY (United States); Fine, Samson W.; Reuter, Victor E. [Memorial Sloan Kettering Cancer Center, Department of Pathology, New York City, NY (United States)

    2015-10-15

    To investigate Haralick texture analysis of prostate MRI for cancer detection and differentiating Gleason scores (GS). One hundred and forty-seven patients underwent T2- weighted (T2WI) and diffusion-weighted prostate MRI. Cancers ≥0.5 ml and non-cancerous peripheral (PZ) and transition (TZ) zone tissue were identified on T2WI and apparent diffusion coefficient (ADC) maps, using whole-mount pathology as reference. Texture features (Energy, Entropy, Correlation, Homogeneity, Inertia) were extracted and analysed using generalized estimating equations. PZ cancers (n = 143) showed higher Entropy and Inertia and lower Energy, Correlation and Homogeneity compared to non-cancerous tissue on T2WI and ADC maps (p-values: <.0001-0.008). In TZ cancers (n = 43) we observed significant differences for all five texture features on the ADC map (all p-values: <.0001) and for Correlation (p = 0.041) and Inertia (p = 0.001) on T2WI. On ADC maps, GS was associated with higher Entropy (GS 6 vs. 7: p = 0.0225; 6 vs. >7: p = 0.0069) and lower Energy (GS 6 vs. 7: p = 0.0116, 6 vs. >7: p = 0.0039). ADC map Energy (p = 0.0102) and Entropy (p = 0.0019) were significantly different in GS ≤3 + 4 versus ≥4 + 3 cancers; ADC map Entropy remained significant after controlling for the median ADC (p = 0.0291). Several Haralick-based texture features appear useful for prostate cancer detection and GS assessment. (orig.)

  1. Haralick texture analysis of prostate MRI: utility for differentiating non-cancerous prostate from prostate cancer and differentiating prostate cancers with different Gleason scores

    International Nuclear Information System (INIS)

    Wibmer, Andreas; Hricak, Hedvig; Sala, Evis; Vargas, Hebert Alberto; Gondo, Tatsuo; Matsumoto, Kazuhiro; Eastham, James; Veeraraghavan, Harini; Fehr, Duc; Zheng, Junting; Goldman, Debra; Moskowitz, Chaya; Fine, Samson W.; Reuter, Victor E.

    2015-01-01

    To investigate Haralick texture analysis of prostate MRI for cancer detection and differentiating Gleason scores (GS). One hundred and forty-seven patients underwent T2- weighted (T2WI) and diffusion-weighted prostate MRI. Cancers ≥0.5 ml and non-cancerous peripheral (PZ) and transition (TZ) zone tissue were identified on T2WI and apparent diffusion coefficient (ADC) maps, using whole-mount pathology as reference. Texture features (Energy, Entropy, Correlation, Homogeneity, Inertia) were extracted and analysed using generalized estimating equations. PZ cancers (n = 143) showed higher Entropy and Inertia and lower Energy, Correlation and Homogeneity compared to non-cancerous tissue on T2WI and ADC maps (p-values: <.0001-0.008). In TZ cancers (n = 43) we observed significant differences for all five texture features on the ADC map (all p-values: <.0001) and for Correlation (p = 0.041) and Inertia (p = 0.001) on T2WI. On ADC maps, GS was associated with higher Entropy (GS 6 vs. 7: p = 0.0225; 6 vs. >7: p = 0.0069) and lower Energy (GS 6 vs. 7: p = 0.0116, 6 vs. >7: p = 0.0039). ADC map Energy (p = 0.0102) and Entropy (p = 0.0019) were significantly different in GS ≤3 + 4 versus ≥4 + 3 cancers; ADC map Entropy remained significant after controlling for the median ADC (p = 0.0291). Several Haralick-based texture features appear useful for prostate cancer detection and GS assessment. (orig.)

  2. Perineural invasion and Gleason 7-10 tumors predict increased failure in prostate cancer patients with pretreatment PSA <10 ng/ml treated with conformal external beam radiation therapy

    International Nuclear Information System (INIS)

    Anderson, Penny R.; Hanlon, Alexandra L.; Patchefsky, Arthur; Al-Saleem, Tahseen; Hanks, Gerald E.

    1998-01-01

    Purpose: It has been well established that prostate cancer patients with pretreatment PSA<10 ng/ml enjoy excellent bNED control when treated with definitive external beam radiation therapy. This report identifies predictors of failure for patients with pretreatment PSA <10 ng/ml. These predictors are then used to define favorable and unfavorable prognostic subgroups of patients for which bNED control is compared. Methods and Materials: Between 3/87 and 11/94, 266 patients with T1-T3NXM0 prostate cancer and pretreatment PSA values <10 ng/ml were treated with definitive external beam radiation therapy. Median central axis dose and median follow-up for the entire group was 72 Gy (63-79 Gy) and 48 months (2-120 months). Predictors of bNED control were evaluated univariately using Kaplan-Meier methodology and the log-rank test and multivariately using Cox proportional hazards modeling. Covariates considered were pretreatment PSA, palpation stage, Gleason score, presence of perineual invasion (PNI) and central axis dose. Independent predictors based on multivariate results were then used to stratify the patients into two prognostic groups for which bNED control was compared. bNED failure is defined as PSA ≥ 1.5 ng/ml and rising on two consecutive determinations. Results: Univariate analysis according to pretreatment and treatment factors for bNED control demonstrates a statistically significant improvement in 5-year bNED control for patients with Gleason score 2-6 vs. 7-10, patients without evidence of perineural invasion (PNI) vs. those with PNI, and patients with palpation stage T1/T2AB vs. T2C/T3. Multivariate analysis demonstrates that Gleason score (p = 0.0496), PNI (p = 0.0008) and palpation stage (p = 0.0153) are significant independent predictors of bNED control. Based on these factors, patients are stratified into a more favorable prognosis group (Gleason 2-6, no PNI, and stage T1/T2AB, n = 172) and a less favorable prognosis group (Gleason 7-10 or PNI or T2C

  3. Eestist saab politseiriik / Roy Strider

    Index Scriptorium Estoniae

    Strider, Roy, 1974-

    2007-01-01

    Autori väitel ei ole politsei pärast kavandatavat avaliku koosoleku seaduse muutmist enam kohustatud inimestele teatama, kui nende eraelu puutumatust on jälitustoiminguga riivatud. Autori sõnul tähendab see, et Eestist saab politseiriik

  4. Maainimesed ja kodanikud / Roy Strider

    Index Scriptorium Estoniae

    Strider, Roy, 1974-

    2010-01-01

    Autor hindab kriitiliselt kodanikuühiskonna tekkimise võimalusi kampaaniate korras. Regionaalarengu projektide finantseerimisel tuleks rohkem arvestada kohalikke vajadusi, mitte projektikirjutaja oskusi

  5. Meie unistuste internet / Roy Strider

    Index Scriptorium Estoniae

    Strider, Roy, 1974-

    2009-01-01

    Identiteedimoondamistest ja mainerünnetest virtuaalreaalsuses. Autor leiab, et internet on oma näilises vabaduses muutunud oluliseks võitlustandriks valitsustele, erakondadele ning ettevõtetele ja võib ületada oma kasulikkuse kriitilise piiri. Spinnimiset, mis on info edastamine (ka moonutustega) sellisel moel, et keegi sellest kasu saab.

  6. High-Risk Prostate Cancer With Gleason Score 8–10 and PSA Level ≤15 ng/ mL Treated With Permanent Interstitial Brachytherapy

    International Nuclear Information System (INIS)

    Fang, L. Christine; Merrick, Gregory S.; Butler, Wayne M.; Galbreath, Robert W.; Murray, Brian C.; Reed, Joshua L.; Adamovich, Edward; Wallner, Kent E.

    2011-01-01

    Purpose: With widespread prostate-specific antigen (PSA) screening, there has been an increase in men diagnosed with high-risk prostate cancer defined by a Gleason score (GS) ≥8 coupled with a relatively low PSA level. The optimal management of these patients has not been defined. Cause-specific survival (CSS), biochemical progression-free survival (bPFS), and overall survival (OS) were evaluated in brachytherapy patients with a GS ≥8 and a PSA level ≤15 ng/mL with or without androgen-deprivation therapy (ADT). Methods and Materials: From April 1995 to October 2005, 174 patients with GS ≥8 and a PSA level ≤15 ng/mL underwent permanent interstitial brachytherapy. Of the patients, 159 (91%) received supplemental external beam radiation, and 113 (64.9%) received ADT. The median follow-up was 6.6 years. The median postimplant Day 0 minimum percentage of the dose covering 90% of the target volume was 121.1% of prescription dose. Biochemical control was defined as a PSA level ≤0.40 ng/mL after nadir. Multiple parameters were evaluated for impact on survival. Results: Ten-year outcomes for patients without and with ADT were 95.2% and 92.5%, respectively, for CSS (p = 0.562); 86.5% and 92.6%, respectively, for bPFS (p = 0.204); and 75.2% and 66.0%, respectively, for OS (p = 0.179). The median post-treatment PSA level for biochemically controlled patients was <0.02 ng/mL. Multivariate analysis failed to identify any predictors for CSS, whereas bPFS and OS were most closely related to patient age. Conclusions: Patients with GS ≥8 and PSA level ≤15 ng/mL have excellent bPFS and CSS after brachytherapy with supplemental external beam radiotherapy. The use of ADT did not significantly impact bPFS, CSS, or OS.

  7. Book Review: The future of spacetime. Stephen William Hawking (ed.); Kip S. Thorne, Igor Novikov, Timothy Ferris, Alan Lightman, and Richard Price, W.W. Norton & Company, 2002, 224 pp., US 25.95, ISBN 0393020223

    Science.gov (United States)

    Smeenk, Chris

    2003-12-01

    The study of Einstein's theory of general relativity experienced a renaissance beginning in the early 1960s. Prior to this resurgence of interest, general relativity was isolated from mainstream physics-admired for its elegance, perhaps, but only from a distance. The generation of students who risked their careers by entering this neglected field has now reached the age of festschrifts. In June of 2000, Caltech hosted ;Kipfest,; a conference in honor of Kip Thorne's 60th birthday. Thorne started graduate school at Princeton in 1962 and began research in general relativity under John Wheeler's guidance in the heady early days of the renaissance. Since then, he has played a prominent role in general relativity: as co-author of the influential textbook Gravitation, as a leader in research regarding astrophysical applications of Einstein's theory, and as a co-founder and chief advocate for the Laser Interferometer Gravitational Wave Observatory (LIGO), to mention a few aspects of his far-reaching work. ;Kipfest; included 14 speakers discussing fields to which Thorne has contributed. But the conference also reflected Thorne's long-standing commitment to communicating science to a general audience: Igor Novikov, Stephen Hawking, Timothy Ferris, and Alan Lightman gave popular talks at ;Kipfest,; with Thorne himself tricked into delivering a fifth. The Future of Spacetime gathers adaptations of these five lectures, along with a lengthy introductory essay by Richard Price.

  8. The influence of prostate-specific antigen density on positive and negative predictive values of multiparametric magnetic resonance imaging to detect Gleason score 7-10 prostate cancer in a repeat biopsy setting.

    Science.gov (United States)

    Hansen, Nienke L; Barrett, Tristan; Koo, Brendan; Doble, Andrew; Gnanapragasam, Vincent; Warren, Anne; Kastner, Christof; Bratt, Ola

    2017-05-01

    To evaluate the influence of prostate-specific antigen density (PSAD) on positive (PPV) and negative (NPV) predictive values of multiparametric magnetic resonance imaging (mpMRI) to detect Gleason score ≥7 cancer in a repeat biopsy setting. Retrospective study of 514 men with previous prostate biopsy showing no or Gleason score 6 cancer. All had mpMRI, graded 1-5 on a Likert scale for cancer suspicion, and subsequent targeted and 24-core systematic image-fusion guided transperineal biopsy in 2013-2015. The NPVs and PPVs of mpMRIs for detecting Gleason score ≥7 cancer were calculated (±95% confidence intervals) for PSAD ≤0.1, 0.1-0.2, ≤0.2 and >0.2 ng/mL/mL, and compared by chi-square test for linear trend. Gleason score ≥7 cancer was detected in 31% of the men. The NPV of Likert 1-2 mpMRI was 0.91 (±0.04) with a PSAD of ≤0.2 ng/mL/mL and 0.71 (±0.16) with a PSAD of >0.2 ng/mL/mL (P = 0.003). For Likert 3 mpMRI, PPV was 0.09 (±0.06) with a PSAD of ≤0.2 ng/mL/mL and 0.44 (±0.19) with a PSAD of >0.2 ng/mL/mL (P = 0.002). PSAD also significantly affected the PPV of Likert 4-5 mpMRI lesions: the PPV was 0.47 (±0.08) with a PSAD of ≤0.2 ng/mL/mL and 0.66 (±0.10) with a PSAD of >0.2 ng/mL/mL (P prostate cancer, not only in men with negative mpMRI, but also in men with equivocal imaging. Surveillance, rather than repeat biopsy, may be appropriate for these men. Conversely, biopsies are indicated in men with a high PSAD, even if an mpMRI shows no suspicious lesion, and in men with an mpMRI suspicious for cancer, even if the PSAD is low. © 2016 The Authors BJU International © 2016 BJU International Published by John Wiley & Sons Ltd.

  9. Can a Gleason 6 or Less Microfocus of Prostate Cancer in One Biopsy and Prostate-Specific Antigen Level <10 ng/mL Be Defined as the Archetype of Low-Risk Prostate Disease?

    Directory of Open Access Journals (Sweden)

    Gianluigi Taverna

    2012-01-01

    Full Text Available Prostate cancer (PC remains a cause of death worldwide. Here we investigate whether a single microfocus of PC at the biopsy (graded as Gleason 6 or less, ≤5% occupancy and the PSA <10 ng/mL can define the archetype of low-risk prostate disease. 4500 consecutive patients were enrolled. Among them, 134 patients with a single micro-focus of PC were followed up, and the parameters influencing the biochemical relapse (BR were analysed. Out of 134 patients, 94 had clinically significant disease, specifically in 74.26% of the patients with PSA <10 ng/mL. Positive surgical margins and the extracapsular invasion were found in 29.1% and 51.4% patients, respectively. BR was observed in 29.6% of the patients. Cox regression evidenced a correlation between the BR and Gleason grade at the retropubic radical prostatectomy (RRP, capsular invasion, and the presence of positive surgical margins. Multivariate regression analysis showed a statistically significant correlation between the presence of surgical margins at the RRP and BR. Considering a single micro-focus of PC at the biopsy and PSA serum level <10 ng/mL, clinically significant disease was found in 74.26% patients and only positive surgical margins are useful for predicting the BR.

  10. Histogram analysis of stretched-exponential and monoexponential diffusion-weighted imaging models for distinguishing low and intermediate/high gleason scores in prostate carcinoma.

    Science.gov (United States)

    Liu, Wei; Liu, Xiao H; Tang, Wei; Gao, Hong B; Zhou, Bing N; Zhou, Liang P

    2018-02-07

    Noninvasive measures to evaluate the aggressiveness of prostate carcinoma (PCa) may benefit patients. To assess the value of stretched-exponential and monoexponential diffusion-weighted imaging (DWI) for predicting the aggressiveness of PCa. Retrospective study. Seventy-five patients with PCa. 3T DWI examinations were performed using b-values of 0, 500, 1000, and 2000 s/mm 2 . The research were based on entire-tumor histogram analysis and the reference standard was radical prostectomy. The correlation analysis was programmed with Spearman's rank-order analysis between the histogram variables and Gleason grade group (GG). Receiver operating characteristic (ROC) regression was used to analyze the ability of these histogram variables to differentiate low-grade (LG) from intermediate/high-grade (HG) PCa. The percentiles and mean of apparent diffusion coefficient (ADC) and distributed diffusion coefficient (DDC) were correlated with GG (ρ: 0.414-0.593), while there was no significant relation among α value, skewnesses, and kurtosises with GG (ρ:0.034-0.323). HG tumors (ADC:484 ± 136, 592 ± 139, 670 ± 144, 788 ± 146, 895 ± 141 mm 2 /s; DDC: 410 ± 142, 532 ± 172, 666 ± 193, 786 ± 196, 914 ± 181 mm 2 /s) had lower values in the 10 th , 25 th , 50 th , 75 th percentiles and means than LG tumors (ADC: 644 ± 779, 737 ± 84, 836 ± 83, 919 ± 82, 997 ± 107 mm 2 /s; DDC: 552 ± 82, 680 ± 94, 829 ± 112, 931 ± 106, 1045 ± 100 mm 2 /s). However, there was no difference between LG and HG tumors in α value (0.671 ± 0.041 vs. 0.633 ± 0.114), kurtosises (ADC 0.09 vs. 0.086; DDC -0.033 vs. -0.317), or skewnesses (ADC -0.036 vs. 0.073; DDC -0.063 vs. 0.136). The above statistics were P Histogram variables of DDC and ADC may predict the aggressiveness of PCa, while α value does not. The abilities of ADC10 and DDC10 to discriminate LG from HG tumors were similar, and

  11. Using pre-treatment PSA and Gleason score to predict for extra capsular extension among patients with clinically staged organ confined prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Anita; Roach, Mack; Diaz, Aidnag; Marquez, Carol; Chinn, Dan; Coleman, Lori; Presti, Joseph; Carroll, Peter

    1995-07-01

    Purpose/Objectives: The patients most suitable for a radical prostatectomy (RP) are those with organ confined disease. At least(1(3)) of patients with clinically staged organ confined disease will be found to have extra capsular extension (ECE) following RP. The purpose of this study is to assess the predictive value of an equation for predicting the risk of ECE based on the pre-treatment prostatic specific antigen (PSA) and Gleason score (GS) in patients with clinical stage T1/T2 prostate cancer. Materials and Methods: Two hundred and twenty-two patients who underwent RP at either the San Francisco VAMC or UCSF between 1988 and 1994 were eligible for this analysis. Patients were considered eligible if the pathological stage, pre-operative PSA and GS were available. Among these patients the median pre-operative PSA was 9 ng/ml (range 0 - 195 ng/ml), and the median pre-operative GS was 6 (range 2-10). The empirically derived equations tested were [1.5 x PSA + (GS - 3) x 10] (Roach, J. Urol., 150: 1923-1924, 1993) as well as a recent modification of this equation of [PSA + (GS - 3.5) x 10]. For these equations, the range of calculated risk was limited to 0 - 100%. Results: The results of using these two equations are shown graphically. Using the modified equation, with a calculated risk (CR) of {<=}25% and an average calculated risk (ACR) of 15.4%, the observed incidence (OI) of ECE was 17.2%. Among the patients with a CR of 26 to 50% and an ACR of 36.1%, the OI of ECE was 38.4%. Among the patients with a CR of 51 to 75% and an ACR of 60.4%, the OI of ECE was 62.7%. Finally, among the patients with a CR of 76 to 100% and an ACR of 77.3%, the OI of ECE was 85.7%. Transrectal ultrasound (TRUS) or magnetic resonance imaging (MRI) reports were available in 72 patients. Correlation with TRUS demonstrated a sensitivity and specificity of 52.4% and 56.1% respectively. Correlation with MRI showed a sensitivity of 57.9% and a specificity of 45.5%. The use of either MRI or

  12. Le rôle de l’intertexte et du palimpseste dans la création d’une Écosse mythique dans Waverley et Rob Roy de Walter Scott

    Directory of Open Access Journals (Sweden)

    Céline SABIRON

    2010-03-01

    Full Text Available L’Écosse des Lumières, récemment rattachée à sa puissante voisine anglaise par l’Acte d’Union de 1707, connaît une crise identitaire qui l’amène à une redéfinition de son image. Sa représentation, tant tangible, physique que mentale, nationale, passe par une réécriture de son Histoire par le mythe, ce récit imaginaire populaire ou littéraire mettant en scène des êtres surhumains et des actions remarquables qui est, selon Roland Barthes, « un discours, un système de communication, un message » (Mythologies. Ce message d’une re-construction identitaire est transmis par Walter Scott dans ses romans écossais, en particulier Waverley et Rob Roy qui dépeignent l’Écosse et ses habitants à travers les yeux naïfs d’érudits anglais. Ce portrait textuel, loin d’être un tableau réaliste, est brossé à l’aide d’une superposition d’images mythiques et littéraires, notamment dans la description des paysages des Highlands. De plus, les personnages, tel le héros populaire historique et hors-la-loi écossais Rob Roy, sont transformés, romancés, mythifiés dans ces fictions qui retracent, sous forme d’épopée, les grandes révoltes jacobites de 1715 et 1745. Enfin, le langage pictural et imagé contribue à véhiculer une vision mythique de l’Écosse. Nous chercherons donc à comprendre et à expliquer les motivations et les répercussions de ce maillage d’images fictives connues, tirées de mythes ou d’ouvrages littéraires, et tissées au moyen d’images rhétoriques au texte scottien pour créer nouveau visage écossais.Recently united to its powerful English twin sister through the 1707 Union Act, Scotland experiences a major identity crisis in the Enlightenment. Politically, religiously, and socially divided, it is led to redefine its image by rewriting history through mythology. A myth is “a speech, a system of communication, a message”, Roland Barthes explains in Mythologies. This message

  13. Extent of disease in recurrent prostate cancer determined by [(68)Ga]PSMA-HBED-CC PET/CT in relation to PSA levels, PSA doubling time and Gleason score.

    Science.gov (United States)

    Verburg, Frederik A; Pfister, David; Heidenreich, Axel; Vogg, Andreas; Drude, Natascha I; Vöö, Stefan; Mottaghy, Felix M; Behrendt, Florian F

    2016-03-01

    To examine the relationship between the extent of disease determined by [(68)Ga]PSMA-HBED-CC-PET/CT and the important clinical measures prostate-specific antigen (PSA), PSA doubling time (PSAdt) and Gleason score. We retrospectively studied the first 155 patients with recurrent prostate cancer (PCA) referred to our university hospital for [(68)Ga]PSMA-HBED-CC PET/CT. PET/CT was positive in 44%, 79% and 89% of patients with PSA levels of ≤1, 1-2 and ≥2 ng/ml, respectively. Patients with high PSA levels showed higher rates of local prostate tumours (p PSA and PSAdt were independent determinants of scan positivity and of extrapelvic lymph node metastases. PSAdt was the only independent marker of bone metastases (p = 0.001). Of 20 patients with a PSAdt PSA ≥2 ng/ml, 19 (95%) had a positive scan and 12 (60%) had M1a disease. Of 14 patients with PSA 6 months, only 5 (36%) had a positive scan and 1 (7%) had M1a disease. [(68)Ga]PSMA-HBED-CC PET/CT will identify PCA lesions even in patients with very low PSA levels. Higher PSA levels and shorter PSAdt are independently associated with scan positivity and extrapelvic metastases, and can be used for patient selection for [(68)Ga]PSMA-HBED-CC PET/CT.

  14. Seed germination and seedling vigour of italian ryegrass, cocksfoot and timothy following harvest and storage Germinação de sementes e o vigor de plantas jovens de azevem italiano, dactilis e timóteo após a colheita e o armazenamento

    Directory of Open Access Journals (Sweden)

    Rade Stanisavljevic

    2011-12-01

    Full Text Available During post-harvest maturation, different species vary in the length of dormancy breaking or germination increases. Seed dormancy and slow seedling development often limit establishment of forage grass stands. Seed germination and seedling vigour of Italian ryegrass (Lolium italicum A. Braun, Synonym Lolium multiflorum L., cocksfoot (Dactylis glomerata L. and timothy (Phleum pretense L. were observed after harvest and storage. After harvest in June, seeds were stored under standard storage conditions and sampled every 30 days after harvest (DAH, up to 270 DAH, and then every 60 days up to 990 DAH. At each date, seeds were tested for final germination percentage and for seedling vigour traits. Timothy seeds had a maximum germination (88% and the best seedlings vigour at 90 DAH, which implies that early autumn (September-October is the best sowing period for freshly harvested seeds of timothy. Timothy seed germination was poor from 270 DAH (73%. The best germination and vigour of Italian ryegrass and cocksfoot seedlings were between 270 and 330 DAH, which equates to spring sowing time (March-April in the succeeding year. Cocksfoot and Italian ryegrass seeds maintained satisfactory germination levels up to 630 DAH (81% and 810 DAH (81%, respectively. The data can serve for the determination of a proper storage duration management between harvest and sowing of the tested species under ambient conditions of south-eastern Europe.Durante o armazenamento, diferentes espécies comportam-se diferentemente quanto à dormência e crescimento de plântulas. A dormência o desenvolvimento lento das plântulas limitam a época do plantio das gramíneas forrageiras plurianuais. A germinação de sementes e o crescimento das plântulas de azevem italiano (Lolium italicum A. Braun sin. Lolium multiflorum L., Dactilis (Dactilis glomerata L. e de timoteo (Phleum pratense L. foi pesquisada durante a maturação pós-colheita e a silagem. Após a colheita, em junho

  15. Crise hipertensiva: estudo de caso com utilização da classificação das intervenções de enfermagem para alcançar respostas adaptativas baseadas no Modelo Teórico de Roy Crisis hipertensiva: estudio de caso con utilización de la clasificación de las intervenciones de enfermería para alcanzar respuestas adaptativas basadas en el Modelo Teórico de Roy Hypertensive crisis: case study with use of the nursing interventions classification in order to reach adaptive responses based in the Roy’s Theoretic Model

    Directory of Open Access Journals (Sweden)

    Maria Vilaní Cavalcante Guedes

    2005-09-01

    Full Text Available INTRODUÇÃO: Por acreditarmos que as complicações da hipertensão arterial surgem em decorrência da falta de adaptação do cliente à doença e ao tratamento, neste estudo trabalharemos com o modelo conceitual de enfermagem proposto por Roy e Andrews, conhecido como Modelo de Adaptação, na tentativa de descobrir meios de cuidar destas pessoas, ajudando-as a se manterem adaptadas e integradas. OBJETIVO: Este trabalho objetivou descrever as intervenções de enfermagem coerentes com a situação de crise hipertensiva, com apoio na Classificação das Intervenções de Enfermagem (NIC, buscando a interface com o Modelo de Adaptação de Roy. MÉTODO: Trata-se de pesquisa tipo estudo de caso realizada com cliente em crise hipertensiva atendida em um serviço especializado em hipertensão e diabetes em Fortaleza, no período de setembro a novembro de 2003, com dados coletados no serviço e no domicílio da cliente. RESULTADOS: Como apontam os resultados, existem dificuldades adaptativas em todos os modos. Por isto, as intervenções de enfermagem selecionadas da NIC foram implementadas com o apoio da família. CONCLUSÃO: Conclui-se ser viável a abordagem de cliente tendo por base os conceitos do Modelo Adaptativo de Roy e as intervenções de enfermagem da referida classificação.INTRODUCCIÓN: Por creermos que las complicaciones de la hipertensión arterial en decurrencia de la falta de adaptación del cliente a la enfermedad y al tratamiento, trabajaremos en este trabajo con el modelo conceptual de enfermería propuesto por Roy y Andrews, conocido como Modelo de Adaptación, intentando descubrir medios de cuidar de estas personas, ayudándolas a se manteneren adaptadas e integradas. OBJETIVO: Este trabajo ha objetivado describir las intervenciones de enfermería coherentes con la situación de crisis de hipertensión, con apoyo en la Clasificación de las Intervenciones de Enfermería (NIC, buscando la interfaz con el Modelo de Adaptaci

  16. Timothy Garton Ash : eurovalimiste tulemus hakkab meenutama loomaaeda / Timothy Garton Ash

    Index Scriptorium Estoniae

    Garton Ash, Timothy, 1955-

    2009-01-01

    Intervjuu Briti ajaloolase ja politoloogiga praegusest kriisist, protektsionismist, Euroopast ja selle ühtsuse suurendamise vajadusest, Euroopa Parlamendist ja selle valimistest, Euroopa Liidust. Professori arvates võiks kaaluda Euroopa Nõukogu ja Euroopa Komisjoni presidendi otsevalimist

  17. PI-RADS version 2 for prediction of pathological downgrading after radical prostatectomy: a preliminary study in patients with biopsy-proven Gleason Score 7 (3+4) prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Woo, Sungmin; Kim, Sang Youn [Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Lee, Joongyub [Seoul National University College of Medicine, Seoul National University Hospital, Division of Clinical Epidemiology, Medical Research Collaborating Center, Biomedical Research Institution, Seoul (Korea, Republic of); Kim, Seung Hyup; Cho, Jeong Yeon [Seoul National University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Seoul National University Medical Research Center, Institute of Radiation Medicine and Kidney Research Institute, Seoul (Korea, Republic of)

    2016-10-15

    To evaluate PI-RADSv2 for predicting pathological downgrading after radical prostatectomy (RP) in patients with biopsy-proven Gleason score (GS) 7(3+4) PC. A total of 105 patients with biopsy-proven GS 7(3+4) PC who underwent multiparametric prostate MRI followed by RP were included. Two radiologists assigned PI-RADSv2 scores for each patient. Preoperative clinicopathological variables and PI-RADSv2 scores were compared between patients with and without downgrading after RP using the Wilcoxon rank sum test or Fisher's exact test. Logistic regression analyses with Firth's bias correction were performed to assess their association with downgrading. Pathological downgrading was identified in ten (9.5 %) patients. Prostate-specific antigen (PSA), PSA density, percentage of cores with GS 7(3+4), and greatest percentage of core length (GPCL) with GS 7(3+4) were significantly lower in patients with downgrading (p = 0.002-0.037). There was no significant difference in age and clinical stage (p = 0.537-0.755). PI-RADSv2 scores were significantly lower in patients with downgrading (3.8 versus 4.4, p = 0.012). At univariate logistic regression analysis, PSA, PSA density, and PI-RADSv2 scores were significant predictors of downgrading (p = 0.003-0.022). Multivariate analysis revealed only PSA density and PI-RADSv2 scores as independent predictors of downgrading (p = 0.014-0.042). The PI-RADSv2 scoring system was an independent predictor of pathological downgrading after RP in patients with biopsy-proven GS 7(3+4) PC. (orig.)

  18. Tiibeti viimane võimalus / Roy Strider

    Index Scriptorium Estoniae

    Strider, Roy, 1974-

    2008-01-01

    Tiibeti väljaõppeta vabadusvõitlejate-meeleavaldajate piinamistest hiinlaste poolt, Hiina võimude taktikast konflikti lahendamisel. Tiibeti ülestõusu peaeesmärgiks on oma jõuriismeid kokku võttes tõmmata maailma tähelepanu kultuurilisele ja füüsilisele genotsiidile, kirjutab autor

  19. Ei geneetiliselt muundatud toidule! / Roy Strider

    Index Scriptorium Estoniae

    Strider, Roy, 1974-

    2007-01-01

    Jätkates mõttevahetust geneetiliselt muundatud toidu kahjulikkuse või ohutuse üle, kirjutab autor, et teadus pole tänapäeval enam mitte inimeste teenistuses, vaid korporatsioonide ja riikide palgalehel

  20. Regular Gleason Measures and Generalized Effect Algebras

    Science.gov (United States)

    Dvurečenskij, Anatolij; Janda, Jiří

    2015-12-01

    We study measures, finitely additive measures, regular measures, and σ-additive measures that can attain even infinite values on the quantum logic of a Hilbert space. We show when particular classes of non-negative measures can be studied in the frame of generalized effect algebras.

  1. Reproductive biology of Amasonia obovata Gleason (Laminaceae)

    OpenAIRE

    Schvinn,Thays de Assis; Miranda,Anderson Fernandes de; Silva,Celice Alexandre

    2014-01-01

    Floral mechanisms that ensure seed production via autogamy are more likely to occur in species growing in environments where pollination is scarce. Amasonia obovata was studied in the State of Mato Grosso-Brazil, from 2009 to 2012, to analyze the morphological and reproductive characteristics, aside from investigating the association of the reproductive success with the pollinator frequency and identity. The flowering and fruiting of A. obovata was concentrated in a period of five months duri...

  2. {sup 68}Ga-PSMA-11 PET/CT in primary staging of prostate cancer: PSA and Gleason score predict the intensity of tracer accumulation in the primary tumour

    Energy Technology Data Exchange (ETDEWEB)

    Uprimny, Christian; Kroiss, Alexander Stephan; Decristoforo, Clemens; Guggenberg, Elisabeth von; Kendler, Dorota; Scarpa, Lorenza; Di Santo, Gianpaolo; Roig, Llanos Geraldo; Maffey-Steffan, Johanna; Virgolini, Irene Johanna [Medical University Innsbruck, Department of Nuclear Medicine, Innsbruck (Austria); Fritz, Josef [Medical University Innsbruck, Department of Medical Statistics, Informatics and Health Economics, Innsbruck (Austria); Horninger, Wolfgang [Medical University Innsbruck, Department of Urology, Innsbruck (Austria)

    2017-06-15

    Prostate cancer (PC) cells typically show increased expression of prostate-specific membrane antigen (PSMA), which can be visualized by {sup 68}Ga-PSMA-11 PET/CT. The aim of this study was to assess the intensity of {sup 68}Ga-PSMA-11 uptake in the primary tumour and metastases in patients with biopsy-proven PC prior to therapy, and to determine whether a correlation exists between the primary tumour-related {sup 68}Ga-PSMA-11 accumulation and the Gleason score (GS) or prostate-specific antigen (PSA) level. Ninety patients with transrectal ultrasound biopsy-proven PC (GS 6-10; median PSA: 9.7 ng/ml) referred for {sup 68}Ga-PSMA-11 PET/CT were retrospectively analysed. PET images were analysed visually and semiquantitatively by measuring the maximum standardized uptake value (SUV{sub max}). The SUV{sub max} of the primary tumour and pathologic lesions suspicious for lymphatic or distant metastases were then compared to the physiologic background activity of normal prostate tissue and gluteal muscle. The SUV{sub max} of the primary tumour was assessed in relation to both PSA level and GS. Eighty-two patients (91.1%) demonstrated pathologic tracer accumulation in the primary tumour that exceeded physiologic tracer uptake in normal prostate tissue (median SUV{sub max}: 12.5 vs. 3.9). Tumours with GS of 6, 7a (3+4) and 7b (4+3) showed significantly lower {sup 68}Ga-PSMA-11 uptake, with median SUV{sub max} of 5.9, 8.3 and 8.2, respectively, compared to patients with GS >7 (median SUV{sub max}: 21.2; p < 0.001). PC patients with PSA ≥10.0 ng/ml exhibited significantly higher uptake than those with PSA levels <10.0 ng/ml (median SUV{sub max}: 17.6 versus 7.7; p < 0.001). In 24 patients (26.7%), 82 lymph nodes with pathologic tracer accumulation consistent with metastases were detected (median SUV{sub max}: 10.6). Eleven patients (12.2%) revealed 55 pathologic osseous lesions suspicious for bone metastases (median SUV{sub max}: 11.6). The GS and PSA level correlated with

  3. Entre a viagem, a escrita e a publicação do relato, um mar de interesses. Argentina, Chile e Nova Zelândia comparados pelo britânico Robert FitzRoy na década de 1830

    Directory of Open Access Journals (Sweden)

    Gabriel Passetti

    2013-06-01

    Full Text Available Este artigo tem por objetivo discutir as relações entre a viagem, a escrita, a publicação de um relato e os interesses pessoais e a conjuntura social e política no momento de sua redação. A discussão recai sobre as escolhas na seleção de temas e formas de descrever locais, a partir de objetivos pessoais, econômicos ou políticos. São analisadas as imagens da América do Sul e da Oceania presentes no livro Narrative of the surveying voyages of HMS Beagle, produzido pelo comandante da Marinha Britânica Robert FitzRoy, entre os anos de 1836 e 1839, no contexto de intensas discussões e projetos para a expansão do império britânico.

  4. EASTERN MYSTICISM AND TIMOTHY LEARY: HUMAN BEYOND THE CONVENTIONAL REALITY

    Directory of Open Access Journals (Sweden)

    T. V. Danylova

    2017-06-01

    Full Text Available Introduction. The complex multifaceted essence of human as a biological, psychological, social being has attracted the attention of researchers and has caused hot debates during centuries. Still now, human being, her/his nature requires a broader understanding in the context of the synthesis of long-standing philosophical, psychological, religious traditions and contemporary sciences. Purpose. This paper aims to explore the phenomenon of human being through the lens of the Eastern philosophy and T. Leary’s transpersonal perspective. Methodology. Exploratory research design was used for conducting this study. The author has used philosophical hermeneutics, secondary data collected from reports, journals, and periodicals along with own transpersonal experience. Theoretical basis and results. The essence of Eastern worldview is an awareness of unity and coherence of all things and phenomena. All things are the interdependent and interrelated parts of the One Whole: they are the different manifestations of the same unconditional reality. This is Tao for Taoists, Dharmakaya for Buddhists, Brahman for Hindus. These non-dualistic traditions emphasize: we have to transcend our dual thinking in order to perceive true nature of our inner self and to achieve the state of the absolute unity with everything that exists. “Subject – object” duality is illusory. Being disintegrated from the Oneness, a human is dissociated into different parts. The goal of a new interpretation of a human is to reintegrate these poles and transcend them. Merely theoretical approach to the problem of reintegration is insufficient. Reintegration requires a vivid experience of the “liberation” – the experience of enlightenment. This is a transpersonal experience that overcomes our common perception and goes beyond the usual “body-mind” frame. This experience was breathtakingly described by T. Leary. Experimenting with psilocybin and LSD, T. Leary was astonished that creativity was organically based; that human body contained billions of universes; and that human himself was the movement of various forms of energy. T. Leary proposed his own theory of evolution. Originality. The expansion of human horizons leads us to the new understanding/interpretation of a human being. Bringing the Eastern spiritual traditions, which perceive all objects and phenomena as various interrelated aspects of a single supreme reality, transpersonal psychology and modern sciences together, contemporary philosophers are able to design and develop a new approach to a human that will bridge the gap between different interpretations of a human being. T. Leary’s ideas resonate with both quantum physics and the Eastern philosophy. In the 21st century, T. Leary’s ideas are relevant again. Conclusion. The Eastern spiritual teachings and transpersonal experience put the human problem in a completely different context. It induces us to switch from identifying human beings with the body, mind, ego to embracing them as whole organisms interwoven into the fabric of universal entity. This holistic approach, according to which a human is an undivided, alive and organic, ideal and material being, may be seen as a launching pad for a new transdisciplinary paradigm.

  5. Kesk-Euroopa mõistatus / Timothy Garton Ash

    Index Scriptorium Estoniae

    Garton Ash, Timothy, 1955-

    1999-01-01

    Termini Kesk-Euroopa tekkeloost ja erinevatest tõlgendustest. Slovakkia lähiajaloost. Kaart: Lääne tsivilisatsiooni idapiir Samuel Huntingtoni raamatust "The Clash of Civilizations and the Remarking of World Order"

  6. Euroopa tõelised lood / Timothy Garton Ash

    Index Scriptorium Estoniae

    Garton Ash, Timothy, 1955-

    2007-01-01

    Autor arutleb uue Euroopa identiteedi loomise võimalusi kuue väärtuse - vabaduse, rahu, seaduste, jõukuse, mitmekesisuse ja solidaarsuse abil. Vt. samas Nigel Haywood: uued liikmesriigid - rohkem muresid või kogemusi?; Marianne Mikko: Kas Euroopa Liidu laienemisele tuleb piir ette?

  7. Ruling muddies path to election law reform / Timothy Jacobs

    Index Scriptorium Estoniae

    Jacobs, Timothy

    2002-01-01

    Euroopa Inimõiguste Kohtu lahendist, millega mõisteti välja hüvitis Ingrida Podkolzinale, kes ebapiisava riigikeele oskuse tõttu diskvalifitseeriti 1998. aasta Läti parlamendivalimiste kandidaadi kohalt

  8. Vastavad vennad Quayd / Stephen Quay, Timothy Quay ; interv. Heilika Võsu

    Index Scriptorium Estoniae

    Quay, Stephen

    2006-01-01

    IX Pimedate Ööde Filmifestivalil esitlesid animaatoritena tuntud kaksikvennad Quayd oma täispikka mängufimi "Maavärinate klaverihäälestaja" (Piano Tuner of the Earthquakes") : Suurbritannia - Saksamaa - Prantsusmaa 2005. Režissöörid tutvustasid intervjuus ka oma varasemaid tegemisi

  9. Timothy Garton Ash: Euroopas ei tohi olla "mälupoliitikaid" / Timothy Garton Ash ; intervjueerinud Andrei Hvostov

    Index Scriptorium Estoniae

    Garton Ash, Timothy, 1955-

    2009-01-01

    Briti ajaloolane, politoloog ja kolumnist vastab küsimustele, mis puudutavad ajaloo ümberkirjutamist, EL-i välispoliitika kujundamist, Saksamaa katset anda väikeste lastega vanematele hääletamisel lisajõudu, samuti kapitalismi ja sotsialismi, natsismi ja kommunismi

  10. General Roy S. Geiger, USMC: Marine Aviator, Joint Force Commander

    Science.gov (United States)

    2007-06-01

    This is a strong assertion, given the significant and better-known contributions of great Marines such as John Lejeune, Smedley Butler, Alexander...While stationed in Panama, Geiger made a favorable impression on Major Smedley Butler, who later earned the Medal of Honor twice and became a...fifth Naval Aviator. 43 Johnson, 5. 44 Robert Sherrod, History of Marine Corps Aviation in World War II (Baltimore, MD: The Nautical and Aviation

  11. Timothy grass pollen extract-induced gene expression and signalling pathways in airway epithelial cells

    NARCIS (Netherlands)

    Röschmann, K. I. L.; Luiten, S.; Jonker, M. J.; Breit, T. M.; Fokkens, W. J.; Petersen, A.; van Drunen, C. M.

    2011-01-01

    Grass pollen allergy is one of the most common allergies worldwide and airborne allergens are the major cause of allergic rhinitis. Airway epithelial cells (AECs) are the first to encounter and respond to aeroallergens and are therefore interesting targets for the development of new therapeutics.

  12. Timothy grass pollen extract-induced gene expression and signalling pathways in airway epithelial cells

    NARCIS (Netherlands)

    Röschmann, K.I.L.; Luiten, S.; Jonker, M.J.; Breit, T.M.; Fokkens, W.J.; Petersen, A.; van Drunen, C.M.

    2011-01-01

    Background: Grass pollen allergy is one of the most common allergies worldwide and airborne allergens are the major cause of allergic rhinitis. Airway epithelial cells (AECs) are the first to encounter and respond to aeroallergens and are therefore interesting targets for the development of new

  13. Head töötajad lahkuvad? / Timothy Butler, James Waldroop

    Index Scriptorium Estoniae

    Butler, Timothy

    2006-01-01

    Harvardi Ärikooli ärijuhtimisprogrammi juhid avaldasid 1999. aastal artikli "Job sculpting: the art of retaining your best people", milles väljendavad veendumust, et ärialal tegelevaid inimesi motiveerib tegutsema mitte raha, vaid eelkõige nende loomuomased vajadused

  14. Kuhu nüüd, Euroopa? / Timothy Garton Ash ; tõlkinud Janek Salme

    Index Scriptorium Estoniae

    Garton Ash, Timothy, 1955-

    2009-01-01

    Autori arvates pole praegune Euroopa suuremeelne Euroopa, millest unistasid 1989. a. visionäärid, ning on küsimus, kas suudame tagasi saada osa tolleaegsest strateegilisest julgusest ja ajalooliselt kujutlusvõimest

  15. Rahvuse või kodanike riik? / Timothy Garton Ash ; intervjueerinud Ahto Lobjakas

    Index Scriptorium Estoniae

    Garton Ash, Timothy, 1955-

    2009-01-01

    Briti ajaloolane ja politoloog ei usu, et Euroopa Liidu mõistet saaks või tuleks eraldada Euroopa ajaloolisest, geograafilisest ja kultuurilisest järjepidevusest, ta eelistab eripartnerlust nii Türgi kui ka Venemaa puhul, aga mitte liikmestaatust

  16. Fööniks Katõni tuhast / Timothy Garton Ash

    Index Scriptorium Estoniae

    Garton Ash, Timothy, 1955-

    2010-01-01

    Autor kirjeldab 1940. aastal NSV Liidu võimude poolt korraldatud Poola ohvitseride hukkamist ja edasist suurt valet, millega ühinesid ka lääneriigid. Võrdleb rahvusvahelise reaktsiooni kontrasti tollase veresauna ning 10. aprillil 2010. aastal Poola presidendi ja tema kaaskonna lennukiga toimunud katastroofi vahel

  17. Euroopa tõehetk / Timothy Garton Ash ; tõlkinud Priit Simson

    Index Scriptorium Estoniae

    Garton Ash, Timothy, 1955-

    2009-01-01

    Käsitledes kriisi Euroopas, sh. Ida- ja Kesk-Euroopa riikides, ütleb autor, et Euroopa projekti tulevik on küsimärgi all. Edasiminekuks vajab Euroopa praktilist konstruktsiooni, selle saavutamine sõltub globaalsetest jõududest, Euroopa juhtide tasemest ning rahvuslike valijate võimaldatud tegevusruumist ja usaldusest

  18. Autoritaarse kapitalismi pealetung / Timothy Garton Ash ; tõlk. Priit Simson

    Index Scriptorium Estoniae

    Garton Ash, Timothy, 1955-

    2008-01-01

    Autor on seisukohal, et 8. augustil teatasid oma naasmisest ajalooareenile kaks suurriiki: Venemaa ja Hiina. Nad on esitanud väljakutse läänele ning esindavad alternatiivseid versioone autoritaarsest kapitalismist või kapitalistlikust autoritarismist

  19. 75 FR 32210 - United States v. Idaho Orthopaedic Society, Timothy Doerr, Jeffrey Hessing, Idaho Sports Medicine...

    Science.gov (United States)

    2010-06-07

    ..., Jeffrey Hessing, Idaho Sports Medicine Institute, John Kloss, David Lamey, and Troy Watkins; Proposed... Sports Medicine Institute, John Kloss, David Lamey, and Troy Watkins, Civil Case No. 10-268. On May 28..., Jeffrey Hessing, Idaho Sports Medicine Institute, John Kloss, David Lamey, and Troy Watkins, Defendants...

  20. The Urlinie in Hindemith's String quartet op. 22, second movement / Timothy L. Jackson

    Index Scriptorium Estoniae

    Jackson, Timothy L.

    2008-01-01

    Hindemithi Neljanda keelpillikvarteti 2. osa muusikaanalüüs. Muusikalooline taust Paul Hindemithi, Heinrich Schenkeri, Wilhelm Furtwängleri, Bruno Stürmeri ja Gerhard Albersheimi kirjavahetuse varal. Artikli lõpus saksakeelsed originaalkirjad

  1. Kas Euroopa saab Euroopaks? / Timothy Garton Ash ; tõlk. Aet Varik

    Index Scriptorium Estoniae

    Garton Ash, Timothy, 1955-

    2002-01-01

    3. aprillil 1996 peetud Sanford S. Elbergi nim. loeng California Ülikooli (Berkeley) Rahvusvaheliste Uuringute Instituudis. Euroopa määratlus enne 1945. aastat, 1945-1989, külma sõja järgsel perioodil ja tänapäeval

  2. Burden and outcome of acute otitis media in rural Bangladesh | Roy ...

    African Journals Online (AJOL)

    Objectives. To report on the burden and outcome of episodes of acute otitis media (AOM) based on awareness of AOM and compliance to referral by community health workers (CHWs) in rural children aged under 2 in Bangladesh. Study design. Retrospective population-based cohort study. Method. Secondary data ...

  3. Older Adults Making End of Life Decisions: An Application of Roy's Adaptation Model

    Directory of Open Access Journals (Sweden)

    Weihua Zhang

    2013-01-01

    Full Text Available Purpose. The purpose of this study was to identify variables that influenced completion of advanced directives in the context of adaptation from national data in older adults. Knowledge gained from this study would help us identify factors that might influence end of life discussions and shed light on strategies on effective communication on advance care planning. Design and Method. A model-testing design and path analysis were used to examine secondary data from 938 participants. Items were extracted from the data set to correspond to variables for this study. Scales were constructed and reliabilities were tested. Results. The final path model showed that physical impairment, self-rated health, continuing to work, and family structure had direct and indirect effects on completion of advanced directives. Five percent of the variance was accounted for by the path analysis. Conclusion. The variance accounted for by the model was small. This could have been due to the use of secondary data and limitations imposed for measurement. However, health care providers and families should explore patient’s perception of self-health as well as their family and work situation in order to strategize a motivational discussion on advance directive or end of life care planning.

  4. JPRS Report, Soviet Union, Political Affairs, On Stalin and Stalinism: Historical Essays by Roy Medvedev

    Science.gov (United States)

    1989-07-05

    arrested, but survived difficult trials lasting for many years: A. K. Lebedenko , A. Kosterin, A. S . Gorelov, S . D. Spassky, N. Zabolotsky, I. M...the Early 1930s 43 The Assassination of S . M. Kirov. The Trials of Former Leaders of the Opposition 54 Attack on the Principal Party and State...Chinese in Beijing. I continued collecting materials. In the 1970’ s , there was an opportunity to become familiar with virtually all the books about

  5. Soldier of Franco, Soldier of Christ: Roy Campbell and Spain in the ...

    African Journals Online (AJOL)

    patriotic stand alongside Britain during World War II; his admiration for Franco and the Spanish National Movement with his active participation in the war against Hitler; or the latter with his defence of fascism as the most efficient of revolutions?

  6. I Am Not a Camera: On Visual Politics and Method. A Response to Roy Germano

    NARCIS (Netherlands)

    Yanow, D.

    2014-01-01

    No observational method is "point and shoot." Even bracketing interpretive methodologies and their attendant philosophies, a researcher-including an experimentalist-always frames observation in terms of the topic of interest. I cannot ever be "just a camera lens," not as researcher and not as

  7. RICCI and matter collineations of som-roy chaudhary symmetric space time

    International Nuclear Information System (INIS)

    Ramzan, M.; Ahmed, Y.; Mufti, M.

    2018-01-01

    This paper is devoted to explore the RICCI and MCs (Matter Collineations of the Som-Ray Chaudhary spacetime. The spacetime under consideration is one of the spatially homogeneous and rotating spacetimes. Collineations are the some kinds of the Lie symmetries. To discuss the required collineations we have used the RICCI and energy momentum tensors. As the RICCI tensor is formulated from the metric tensor, it must possess its symmetries. RCs (RICCI Collineations) leads to conservation laws. On the other hand for the distribution of matter in the spacetimes, the symmetries of energy momentum tensor or MCs provides conservation laws on matter field. Throughout this paper, these collineations are discussed by vanishing Lie derivative of RICCI and energy momentum tensors respectively. Complete solution of the RCs and MCs equations, which are formed in the result of vanishing Lie derivative are explored. Studying all these collineations in the said spacetime, it has been shown that RCs of the spacetime form an infinite dimensional vector space where as MCs are Killing vector fields. (author)

  8. Research on regularized mean-variance portfolio selection strategy with modified Roy safety-first principle.

    Science.gov (United States)

    Atta Mills, Ebenezer Fiifi Emire; Yan, Dawen; Yu, Bo; Wei, Xinyuan

    2016-01-01

    We propose a consolidated risk measure based on variance and the safety-first principle in a mean-risk portfolio optimization framework. The safety-first principle to financial portfolio selection strategy is modified and improved. Our proposed models are subjected to norm regularization to seek near-optimal stable and sparse portfolios. We compare the cumulative wealth of our preferred proposed model to a benchmark, S&P 500 index for the same period. Our proposed portfolio strategies have better out-of-sample performance than the selected alternative portfolio rules in literature and control the downside risk of the portfolio returns.

  9. Microlocalization and Quantitation of Risk Associated Elements in Gleason Graded Prostate Tissue

    Science.gov (United States)

    2007-03-01

    ORGANIZATION: Regents of the University of California Maya Conn Los Angeles CA 90024 REPORT DATE: March 2007 TYPE OF REPORT...California Maya Conn Los Angeles CA 90024 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S...carcinoma of different histological grading in comparison to normal prostate tissue and adenofibromyomatosis (BPH) Uro Res 10:301-303. 5. Feustel A

  10. Controle de vida da ferramenta do tipo lamina alternada Gleason no fresamento de coroas hipoidais

    OpenAIRE

    Douglas Fontana

    2003-01-01

    Resumo: A transmissão de movimentos mecânicos através de engrenagens é muito utilizado em todos os segmentos industriais.O corte de dentes de engrenagens é uma operação bastante importante dentro da usinagem. Apesar de sua importância, este é um processo pouco estudado, pois esta é uma área bastante restrita de atuação. Emfunção disso,a maior parte dos desenvolvimentos relacionados à tecnologia de corte de dentes de engrenagens ocorre no meio industrial, geralmente de forma empírica. A deter...

  11. Acceptance of the 2014 V.M. Goldschmidt Award of the Gochemical Society by Timothy L. Grove

    Science.gov (United States)

    Grove, Timothy L.

    2015-06-01

    I am deeply honored to be the recipient of the 2014 V.M. Goldschmidt Award. Many of the past recipients of this award have been scientific heroes to me, and it is hard to express how it feels to be included in this distinguished group. My feelings run the full spectrum; from exhilaration and deep personal satisfaction for the recognition of the work that I have done, to humility and anxiety that maybe I am really not good enough to deserve this award. This is called impostor syndrome. You younger scientists should know that many of us, even those who appear very successful, still experience it - don't let it hold you back.

  12. Dose-response relationship of a new Timothy grass pollen allergoid in comparison with a 6-grass pollen allergoid.

    Science.gov (United States)

    Pfaar, O; Hohlfeld, J M; Al-Kadah, B; Hauswald, B; Homey, B; Hunzelmann, N; Schliemann, S; Velling, P; Worm, M; Klimek, L

    2017-11-01

    Subcutaneous allergen immunotherapy with grass pollen allergoids has been proven to be effective and safe in the treatment of patients with allergic rhinoconjunctivitis. Based on the extensive cross-reactivity among Pooideae species, it has been suggested that grass pollen extracts could be prepared from a single species, rather than from a multiple species mixture. To find the optimal dose of a Phleum pratense (P. pratense) allergoid preparation and compare its efficacy and safety to a 6-grass pollen allergoid preparation. In this double-blind, placebo-controlled study (EudraCT: 2011-000674-58), three doses of P. pratense allergoid (1800 therapeutic units (TU), standard-dose 6000 TU and 18 000 TU) were compared with placebo and the marketed 6-grass pollen allergoid (6000 TU). In a pre-seasonal dosing regimen, 102 patients were randomized to five treatment groups and received nine subcutaneous injections. The primary efficacy endpoint was the change in weal size (late-phase reaction [LPR]) in response to the intracutaneous testing (ICT) before and after treatment, comparing the active allergoids to placebo. Secondary outcomes were the change in Total Nasal Symptom Score (TNSS) assessed in the allergen exposure chamber (AEC), the changes in P. pratense-serum-specific IgG 4 and the incidence of adverse events (AEs). All three doses of the P. pratense and the 6-grass pollen allergoid preparations were significantly superior to placebo for the primary outcome, whereas there were no significant differences in the change in TNSS. Compared to the standard-dose, the high-dose of P. pratense did not produce any additional significant benefit, but showed a slight increase in AEs. Yet this increase in AEs was lower than for the 6-grass pollen preparation. The standard-dose of the new P. pratense allergoid was comparable to the marketed 6-grass pollen preparation at equal dose for the parameters measured. © 2017 The Authors. Clinical & Experimental Allergy Published by John Wiley & Sons Ltd.

  13. Identification of genes involved in a water stress response in timothy and mapping of orthologous loci in perennial ryegrass

    DEFF Research Database (Denmark)

    Jonavičienė, Kristina; Studer, Bruno; Asp, Torben

    2012-01-01

    In order to characterize the response of selected grasses to water stress, relative water content (RWC) in leaves and quantum efficiency of photosystem 2 (Fv/Fm) were measured in Phleum pratense L., P. bertolonii DC. and P. phleoides H. Karst. during 6 d of water stress. The results indicated...... differential responses to water stress among the three Phleum species with higher water deficit sensitivity of P. pratense and P. bertolonii than that of P. phleoides. The cDNA-amplified fragment length polymorphism (cDNA-AFLP) technique was applied to identify differentially expressed genes responding...... to water stress in P. pratense. Cloned and sequenced differentially expressed fragments (DEFs) were used for primer design in order to identify orthologous genes in Lolium perenne L. Twelve genes orthologous to P. pratense DEFs were mapped in the L. perenne mapping population VrnA based on a high...

  14. On "islamifašism" õige sõna? / Timothy Garton Ash ; tõlk. Külli-Riin Tigasson

    Index Scriptorium Estoniae

    Garton Ash, Timothy, 1955-

    2008-01-01

    Autor arutleb, kuidas nimetada suitsiiditerroriste ja võimalikke massimõrvareid. Parimaks vastuseks, mis ta seni on leidnud, on sõna "dzhihadistid", eriti "dzhihaadiäärmuslased" või "dzhihaaditerroristid"

  15. 77 FR 39270 - In the Matter of Mr. Timothy Goold; Order Prohibiting Involvement in NRC-Licensed Activities

    Science.gov (United States)

    2012-07-02

    ... qualified radiographer, Mr. Goold disconnected the camera from the crank and guide tube, placed the camera on a snowmobile used to transport it to the radiography truck and departed, telling the inspector he would return shortly. When the inspector walked to [[Page 39271

  16. 77 FR 60119 - Proposed Consent Agreements: DesignerWare, LLC, Timothy Kelly and Ronald P. Koller, Aspen Way...

    Science.gov (United States)

    2012-10-02

    ... the news release describing it. The FTC Act and other laws that the Commission administers permit the...' private information would not be possible. RTO stores also used Detective Mode to send fake ``software.... DesignerWare created several different fake registration forms that its servers displayed on consumers...

  17. THE EFFICIENCY IMPROVING OF PILOTS AND CADETS TRAINING TO SAFETY CONTROL USING THE MODIFICATIONS OF CLASSICAL METHOD OF "ROY" (PSO

    Directory of Open Access Journals (Sweden)

    V. V. Yurasov

    2017-01-01

    Full Text Available The article explains the use of modifications the classical method PSO to optimize the training pilots task on aircraft simulators. Model is based on the identification of the specific guarantee of safety in the task of training pilots of the features of simulation with the use of modern optimization models for long-term quantitative forecast of random processes. The author proved that the classical optimization techniques to aircraft supporting function, the input and output variables, and classes of equations defined by the model author. These circumstances lead to the fact that the obtained models do not have sufficient flexibility that in turn affects their behavior when adding new data points. The increased accuracy and the introduction of additional variables in the optimization problem of security is solved based on the methodology PSO. On the basis of mathematical simulation shows the potential of the PSO for the identification of quality indicators of a new level for the purpose of guaranteeing flight safety. The method of group accounting of arguments presents an original method for solving problems that require structural and parametric identification of models. The author's approach to the problem of optimization consists in taking into account qualitative indicators in terms of aviation events at the gym. On the basis of the mathematical apparatus created a dynamic model based on the classical method PSO. The results obtained are of high precision in compliance with international regulations guaranteeing flight safety and pilot training ICAO and SHEL. Therefore, the method of group accounting of arguments will be effective mathematical tool to build the model and training procedures.

  18. Taassündinud selleks, et tappa / Olivier Roy ; tõlk. Külli-Riin Tigasson

    Index Scriptorium Estoniae

    Roy, Olivier

    2005-01-01

    Islami radikaliseerumisest, fundamentalismist. Autori väitel annavad kristlik ja islamiäärmuslus tunnistust üleilmastumise ajastu kultuurikriisist, islamiäärmusluse kasvulava on eeskätt noorte Euroopa muslimite teine põlvkond

  19. Experiences with Nausea and Vomiting During Pregnancy in Turkish Women Based on Roy Adaptation Model: A Content Analysis

    Directory of Open Access Journals (Sweden)

    Gözde Gökçe İsbir, BSN, PhD

    2013-12-01

    Conclusion: The study findings help nursing staff detect the stimuli and the behaviors of pregnant women with nausea and vomiting. Further research may evaluate the impact of a counseling program prepared under the guidance of a nursing model on nausea and vomiting in pregnancy.

  20. Análisis de los conceptos del modelo de adaptación de Callista Roy

    OpenAIRE

    Díaz de Flores, Leticia; Durán de Villalobos, María Mercedes; Gallego de Pardo, Patricia; Gómez Daza, Bertha; Gómez de Obando, Elizabeth; González de Acuña, Yolanda; Gutiérrez de Giraldo, María del Carmen; Hernández Posada, Ángela; Londoño Maya, Jenny Carolina; Moreno Fergusson, María Elisa; Pérez Giraldo, Beatriz; Rodríguez Carranza, Claudia; Rozo de Arévalo, Clara; Umaña de Lozano, Carmen; Valbuena, Sandra

    2002-01-01

    El artículo presenta el análisis sobre los elementos básicos del modelo de adaptación, que viene realizando el grupo de estudio de la Facultad de Enfermería. Partiendo de una revisión histórica, de los principios filosóficos y científicos que sustentan el modelo, se abordan conceptos como sistema adaptativo humano, ambiente, estímulos, mecanismos de enfrentamiento, nivel de adaptación, salud y meta de enfermería, los cuales orientan el cuidado, teniendo en cuenta la autodeterminación de la pe...

  1. Adaptación en Pacientes con Diabetes Mellitus Type 2, Según Modelo de Roy

    OpenAIRE

    Lazcano Ortíz, Margarita; Salazar Gonzalez, Bertha C

    2009-01-01

    Objetivo. Determinar la influencia entre estímulos focales y contextuales, y la adaptación fisiológica y psicosocial en personas con diabetes Mellitus Tipo 2 (DMT2). Material y método. El diseño fue descriptivo, transversal, predictivo. El muestreo fue probabilístico, sistemático. La muestra con 200 participantes de ambos géneros de 30 a 65 años, se determinó para un 95% de confianza, con una potencia de prueba de 90%. Resultados. Los resultados mostraron que el tiempo desde diagnóst...

  2. Adaptación en pacientes con diabetes Mellitus Tipo 2, según Modelo de Roy

    OpenAIRE

    Margarita Lazcano-Ortiz; Bertha Cecilia Salazar-González

    2009-01-01

    Objetivo. Determinar la influencia entre estímulos focales y contextuales, y la adaptación fisiológica y psicosocial en personas con diabetes Mellitus Tipo 2 (DMT2). Material y método. El diseño fue descriptivo, transversal, predictivo. El muestreo fue probabilístico, sistemático. La muestra con 200 participantes de ambos géneros de 30 a 65 años, se determinó para un 95% de confianza, con una potencia de prueba de 90%. Resultados. Los resultados mostraron que el tiempo desde diagnóstico expli...

  3. Players Off the Field. How Jim Delany and Roy Kramer Took over Big-Time College Sports.

    Science.gov (United States)

    Suggs, Welch

    2000-01-01

    Traces the history of the college football bowl system and describes the movement toward replacing the bowl game system with a national championship playoff system. Focuses on the roles of J. Delany, commission of the Big Ten Conference and R. Kramer, commissioner of the Southeastern Conference, in perpetuating the current college football bowl…

  4. Relativism, regulation and the dangers of indifferent science: the Sir Roy Cameron lecture of the Royal College of Pathologists.

    Science.gov (United States)

    Berry, Colin L

    2010-01-12

    The evaluation of data obtained from scientific investigations is not easy and the process often seems counterintuitive to the uninformed. Some commentators hold the conviction that ideological motives colour all deliberations-this makes it easy to suggest that in any scientific debate an opponent's reason for holding a particular viewpoint or belief depends on his or her motives, rather than their knowledge base. This position may be useful in providing the grounds on which to mount a polemic against any perceived threat (drugs in modern medicine, pesticides in intensive agriculture or genetically modified organisms). However, its existence is not a reason to ignore the fact that the data obtained by use of the scientific method may be of a different kind from that which depends on opinions, honed by prejudices. Here I use prejudice to mean a bias that may be favourable or unfavourable to a particular viewpoint, rather than to a willful disregard of fact or an unreasoning predilection to arrive at a particular answer--the Precautionary Principle is a good example of only considering results that fit a preconceived viewpoint. The conviction that opinions cannot be based on independent thought has led to a disregard of professionalism and the development of the view that who pays you determines your opinion--not your science. This is relativism, which embodies the assertion that knowledge is relative and that ethical truths depend on the individuals and groups holding them-there are no absolutes. This compounds the problems of regulatory toxicology which is always beset by unavoidable uncertainties and suffers from being based on the use of the results of testing procedures many decades old which have themselves failed to incorporate new knowledge about the processes we investigate (see Hartung, 2009). A more vigorous assertion of the particular values of the scientific viewpoint and a willingness to incorporate new knowledge into regulatory decision making is necessary. 2009 Elsevier Ireland Ltd. All rights reserved.

  5. Cancers de la prostate de score de Gleason supérieur ou égal à 8 ...

    African Journals Online (AJOL)

    B. Sine

    13,18 mois. La survie globale de la série à 6, 12, et 24 mois était respectivement de 72,7; 54,5 et 0,9%. La ..... n'est pas un outil de dépistage approprié pour le diagnostic précoce du cancer de ... patients ainsi que la réalisation de la technique de prostatectomie radicale. ... concernant tous les sujets de recherche. Consent ...

  6. Impact of tertiary Gleason pattern 5 on prostate cancer aggressiveness: Lessons from a contemporary single institution radical prostatectomy series

    Directory of Open Access Journals (Sweden)

    Zachary B. Koloff

    2015-01-01

    Conclusion: Our results emphasize the importance of TP5 and suggest that criteria for tertiary pattern reporting in prostate cancer should be standardized. Further studies are needed to evaluate the role of tertiary patterns in prognostic models.

  7. NURE aerial gamma-ray and magnetic detail survey: Gleason Mtn., Washington-Idaho area. Final report

    International Nuclear Information System (INIS)

    1981-05-01

    Volume II contains the following: flight line base map; magnetic contour map, maps for uranium, thorium, potassium, thorium/potassium, uranium/potassium; multi-variate analysis map; geochemical analysis map; radiometric multiple parameter stacked profiles; magnetic and ancillary stacked profile data; statistical summaries and histograms for uranium, thorium, potassium, uranium/potassium, uranium/thorium, and thorium/potassium

  8. Comparison of Timothy grass pollen extract- and single major allergen-induced gene expression and mediator release in airway epithelial cells: a meta-analysis

    NARCIS (Netherlands)

    Röschmann, K.I.L.; van Kuijen, A.M.; Luiten, S.; Jonker, M.J.; Breit, T.M.; Fokkens, W.J.; Petersen, A.; van Drunen, C.M.

    2012-01-01

    BACKGROUND: Seasonal allergic rhinitis (AR) is a global health problem and its prevalence has increased considerably in the last decades. As the allergic response with its clinical manifestations is triggered by only a few proteins within natural extracts, there is an increasing tendency for

  9. Comparison of Timothy grass pollen extract- and single major allergen-induced gene expression and mediator release in airway epithelial cells: a meta-analysis

    NARCIS (Netherlands)

    Röschmann, K. I. L.; van Kuijen, A.-M.; Luiten, S.; Jonker, M. J.; Breit, T. M.; Fokkens, W. J.; Petersen, A.; van Drunen, C. M.

    2012-01-01

    Background Seasonal allergic rhinitis (AR) is a global health problem and its prevalence has increased considerably in the last decades. As the allergic response with its clinical manifestations is triggered by only a few proteins within natural extracts, there is an increasing tendency for

  10. Generation and epitope analysis of human monoclonal antibody isotypes with specificity for the timothy grass major allergen Phl p 5a

    DEFF Research Database (Denmark)

    Hecker, J.; Diethers, A.; Seismann, H.

    2011-01-01

    The scarcity of monoclonal human IgE antibodies with specificity for defined allergens is a bottleneck for the molecular characterisation of allergens and their epitopes. Insights into the characteristics of such antibodies may allow for analyses of the molecular basis underlying allergenicity an...

  11. Effect of increasing plant maturity in timothy-dominated grass silage on the performance of growing/finishing Norwegian Red bulls

    DEFF Research Database (Denmark)

    Randby, Å T; Nørgaard, P; Weisbjerg, Martin Riis

    2010-01-01

    An investigation was made of the potential for attaining high daily live weight (LW) gain, high feeding efficiency and carcass quality in Norwegian Red (NRF) bulls fed grass silage harvested at early stages of maturity, supplemented with minimal amounts of concentrates. Roundbale silage was produ......An investigation was made of the potential for attaining high daily live weight (LW) gain, high feeding efficiency and carcass quality in Norwegian Red (NRF) bulls fed grass silage harvested at early stages of maturity, supplemented with minimal amounts of concentrates. Roundbale silage...... and a formic acid-based additive applied. All silages were preserved with restricted fermentation. Silage DOMD values were 0·747, 0·708 and 0·647 for harvesting time (H) 1, 2 and 3 respectively. Silages were fed ad libitum as sole feed, or supplemented with 2–4 kg concentrate at increasing LW, to six bulls per...... treatment from age 7 months (288 kg) to slaughter at 575 kg. Daily LW gain for bulls fed unsupplemented silage was 1423, 1262 and 936 g, respectively, for H1, H2 and H3, and 1570, 1567 and 1357 g for supplemented bulls. For concentrate-supplemented bulls, higher energy intake increased proportions...

  12. Pretreatment IgE sensitization patterns determine the molecular profile of the IgG4 response during updosing of subcutaneous immunotherapy with timothy grass pollen extract

    DEFF Research Database (Denmark)

    Schmid, Johannes Martin; Würtzen, Peter Adler; Dahl, Ronald

    2016-01-01

    BACKGROUND: Allergen immunotherapy is an effective treatment of allergic rhinoconjunctivitis. Clinical efficacy is associated with improvement of basophil sensitivity and an increase in allergen-specific immunoglobulin concentration. OBJECTIVE: We sought to determine whether changes in allergen...... component-specific serum IgE and IgG4 levels during the updosing phase of subcutaneous immunotherapy (SCIT) are biomarkers of the immunologic changes that can lead to treatment efficacy. METHODS: Twenty-four subjects with grass pollen-induced allergic rhinoconjunctivitis were randomized 3:1 to receive SCIT...... (Alutard SQ) or to an open control group. IgE and IgG4 concentrations were determined for the major allergens Phl p 1 or Phl p 5 by using ImmunoCAP and for 8 grass pollen molecules by using Immuno Solid-phase Allergy Chip (ISAC) before treatment and after updosing. RESULTS: Levels of specific IgE against...

  13. A autoimagem e a autoestima das pessoas com transtornos de pele: uma revisão integrativa da literatura baseada no modelo de Callista Roy

    Directory of Open Access Journals (Sweden)

    Patrícia Britto Ribeiro de Jesus

    2015-01-01

    Full Text Available Objetivo: conocer la relación entre los trastornos de la piel y la alteración del autoconcepto en las personas con afección cutánea. Método: revisión integradora de la literatura desde los descriptores: lesiones, dermatología, y autoimagen. La búsqueda se hizo en las bases Lilacs, SciELO y PubMed, en artículos publicados entre el año 2000 y 2012. Resultados: La revisión integradora mostró los principales efectos psicológicos causados por las enfermedades de la piel y confirmó que, los factores psicosociales relacionados con la autoimagen y la autoestima afectan la vida de las personas. Conclusión: los trastornos de la piel pueden llevar al individuo a buscar estrategias que van desde el aislamiento del cuerpo y el aislamiento social, la negación de la enfermedad y hasta el uso de maquillaje de camuflaje, como muestran las publicaciones. La escasez de estudios publicados que muestran las estrategias a adoptar por los enfer - meros para lidiar con los efectos psicológicos causados por la enfermedad cutánea, evidencian la necesidad de investigar sobre el tema.

  14. Insulin-like growth factor II mRNA binding protein 3 (IMP3 is overexpressed in prostate cancer and correlates with higher Gleason scores

    Directory of Open Access Journals (Sweden)

    Mortezavi Ashkan

    2010-06-01

    Full Text Available Abstract Background The oncofetal protein insulin-like growth factor II mRNA binding protein 3 (IMP3 is an important factor for cell-migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. To our knowledge, IMP3 expression has not been investigated in prostate carcinomas so far. Methods Immunohistochemical stainings for IMP3 were performed on tissue microarray (TMA organized samples from 507 patients: 31 normal prostate tissues, 425 primary carcinomas and 51 prostate cancer metastases or castration-resistant prostate cancers (CRPC. IMP3 immunoreactivity was semiquantitatively scored and correlated with clinical-pathologic parameters including survival. Results IMP3 is significantly stronger expressed in prostate carcinomas compared to normal prostate tissues (p Conclusions Although IMP3 is overexpressed in a significant proportion of prostate cancer cases, which might be of importance for novel therapeutic approaches, it does not appear to possess any immediate diagnostic or prognostic value, limiting its potential as a tissue biomarker for prostate cancer. These results might be corroborated by the fact, that two independent tumor cohorts were separately reviewed.

  15. Combination of prostate specific antigen and pathological stage regarding to gleason score to predict bone metastasis of newly diagnosed prostate cancer

    International Nuclear Information System (INIS)

    Wang Zhen; Zhou Liquan; Gao Jiangping; Shi Lixin; Zhao Xiaoyi; Hong Baofa

    2004-01-01

    To determine the value of tumor grade and serum prostate-specific antigen in predicting skeletal metastases in untreated prostate cancer, the results of bone scans were related retrospectively to levels of serum PSA and tumor Grade based on pathologyical examination in 202 patients with prostate cancer newly diagnosed. Skeletal metastases were present in 7% of patients with serum PSA 100 μg/L. Bone scans are omitted likely in a man newly diagnosed with prostate cancer who has no suggestive clinical features, a serum PSA 100 μg/L. (authors)

  16. Nível de adaptação baseado no modelo de Roy em mães de crianças portadores de Síndrome de Down Mothers with Down syndrome children and their psychosocial level of adaptation according to Roy model

    Directory of Open Access Journals (Sweden)

    Allyne Nóbrega Fortes

    2006-09-01

    Full Text Available Objetivos: analizar el nivel de adaptación psicosocial de madres de niños con Síndrome de Down. Metodología: el muestreo estuvo compuesto por todas las madres de los niños portadores del Síndrome de Down atendidos en un núcleo de tratamiento y estimulación precoz que aceptaron participar de la investigación. Los datos fueron organizados de acuerdo con la técnica del análisis temático. El nivel de adaptación se clasificó en: integrado (solamente indicadores de adaptación positiva, compensatorio (indicadores de adaptación positiva y problemas comunes de adaptación y comprometido (solamente problemas comunes de adaptación. Resultados y discusiones: en el modo del Autoconcepto, se hallaron 12 casos de nivel de adaptación compensatorio, uno de nivel integrado y ninguno comprometido. En el modo de Desempeño de papeles se encontraron 3 entrevistadas con nivel comprometido, 10 casos de nivel integrado y ninguno de nivel compensatorio. En el modo de Interdependencia hubo 10 participantes con nivel integrado, 3 participantes con nivel compensatorio, y ningún caso de nivel de adaptación comprometido. Conclusiones: se verifico que todas las participantes estaban viviendo un nivel de adaptación compensatorio general, si se considera que no se se observó ningún caso de nivel totalmente integrado o comprometido.Objetivo: Analisar o nível de adaptação psicossocial de mães de crianças com Síndrome de Down. Metodologia: A amostra foi composta por todas as mães de crianças portadoras de Síndrome de Down, atendidas em um núcleo de tratamento e estimulação precoce, que aceitaram participar da investigação. Os dados foram organizados de acordo com a técnica da análise temática. O nível de adaptação foi classificado em: integrado (somente indicadores de adaptação positiva, compensatório (indicadores de adaptação positiva e problemas comuns de adaptação e comprometido (somente problemas comuns de adaptação. Resultados e discussões: No modo do Autoconceito, houve 12 casos de nível de adaptação compensatório, um de nível integrado e nenhum comprometido. No modo de Desempenho de papéis houve 3 casos com nível comprometido, 10 casos de nível integrado e nenhum de nível compensatório. No modo de Interdependência houve 10 casos com nível integrado, 3 casos com nível compensatório, e nenhum caso de nível de adaptação comprometido. Conclusões:Verificou-se que todas as participantes estavam vivenciando um nível de adaptação compensatório geral, considerando-se que não foi observado qualquer caso de nível totalmente integrado ou comprometido.Objective: We aimed to analyze the psychosocial adaptation level of mothers with Down’s syndrome children. Methodology: The sampling was composed by all mothers of children carriers of Down’s syndrome, assisted in a treatment and precocious stimulation’s nucleus that accepted. The data were organized following thematic analysis technique. The adaptation level was classified: integrated (only positive adaptation indicators, compensatory (positive adaptation indicators and adaptation common problems and compromised (only adaptation common problems. Results and discussion: In the Self-concept mode, there were 12 cases of compensatory adaptation level, one of integrated level and none committed level. In the Role function mode 3 interviewees reached commited level, in 10 cases integrated level and none of compensatory level. In the Interdependence mode 10 participants existed attained integrated level, 3 participants showed compensatory level, and any case of commited level of adaptation was registered. Conclusions: We verify that all the participants were living a general compensatory adaptation level, whereas any case of completely integrated or commited level was observed.

  17. Fungos conidiais associados ao folhedo de Clusia melchiorii Gleason e C. nemorosa G. Mey. (Clusiaceae em fragmento de Mata Atlântica, BA, Brasil Conidial fungi associated to leaf litter of Clusia melchiorii Gleason and C. nemorosa G. Mey (Clusiaceae in a fragment of Atlantic rainforest, Bahia State, Brazil

    Directory of Open Access Journals (Sweden)

    Flávia Rodrigues Barbosa

    2009-03-01

    Full Text Available Visando ampliar o conhecimento sobre diversidade de fungos conidiais, 10 folhas mortas de três indivíduos de C. melchiorii e de C. nemorosa foram coletadas bimestralmente na Serra da Jibóia, Bahia, no período de outubro/2005 a junho/2006. As folhas foram lavadas em água corrente e mantidas em câmara-úmida durante 30 dias. As estruturas fúngicas foram retiradas para estudo morfológico. Foram identificados 79 táxons de Ascomycota na forma anamórfica. Destes, 78 são hifomicetos e um celomiceto. Do total, 87% ocorreram sobre C. melchiorii e 55% sobre C. nemorosa. A maioria dos fungos apresentou freqüência esporádica e constância acidental. As espécies mais freqüentes foram: Beltrania rhombica Penz., Chaetopsina fulva Rambelli, Dactylaria ficusicola Paulus, Gadek & Hyde, Verticillium theobromae (Turconi Mason & Hughes e Volutella sp. 1 (sobre C. melchiorii e Atroseptaphiale flagelliformis Matsush., Pseudobeltrania sp., Zygosporium gibbum (Sacc., Rousseau & Bommer Hughes, Verticillium theobromae (Turconi Mason & Hughes e Volutella sp. 1 (sobre C. nemorosa. A similaridade de fungos entre as duas espécies de Clusia atingiu 60% e 11 táxons foram constantes nos dois hospedeiros: Atrosetaphiale flagelliformis, Beltraniella portoricensis (Stevens Piroz. & Patil, Chalara alabamensis Jones & Ingram., Cryptophiale kakombensis Piroz., Parasympodiella laxa (Subram. & Vittal, Speiropsis scopiformis Kuthub. & Nawawi, Thozetella cristata Piroz. & Hodges, Umbellidion radulans Sutton & Hodges, Verticillium theobromae, Volutella sp. 2 e Zygosporium gibbum. Os dados mostram que o folhedo produzido por C. melchiorii e C. nemorosa, na Serra da Jibóia, é rico em fungos conidiais. Esses fungos, como decompositores, são importantes para a dinâmica do ecossistema estudado.In order to increase the diversity knowledge of conidial fungi, 10 dead leaves from three individuals of C. nemorosa and C. melchiorii were bimonthly collected at the "Serra da Jibóia", State of Bahia, from October/2005 to June/2006. The leaves were washed with tap water and maintained in moist chamber during 30 days. The fungal structures were collected for morphological studies. Seventy nine taxa of Ascomycota, in the anamorphic state were registered: 78 hyphomycete and one Coelomycete. Most of the species occurred on Clusia melchiorii (87% and 55% on C. nemorosa. The majority of the fungi presented sporadical frequency and accidental constancy. The most frequent species were: Beltrania rhombica Penz., Chaetopsina fulva Rambelli, Dactylaria ficusicola Paulus, Gadek & Hyde, Verticillium theobromae (Turconi Mason & Hughes e Volutella sp. 1 (on C. melchiorii and Atroseptaphiale flagelliformis Matsush., Pseudobeltrania sp., Zygosporium gibbum (Sacc., Rousseau & Bommer Hughes, Verticillium theobromae (Turconi Mason & Hughes and Volutella sp. 1 (on C. nemorosa. The similarity of fungi between the two species of Clusia reached 60% and 11 taxa were constant in both hosts: Atrosetaphiale flagelliformis, Beltraniella portoricensis (Stevens Piroz. & Patil, Chalara alabamensisJones & Ingram., Cryptophiale kakombensis Piroz., Parasympodiella laxa (Subram. & Vittal, Speiropsis scopiformis Kuthub. & Nawawi, Thozetella cristata Piroz. & Hodges, Umbellidion radulans Sutton & Hodges, Verticillium theobromae, Volutella sp. 2 and Zygosporium gibbum. The data show that the litter produced by C. melchiorii and C. nemorosa, at the Serra da Jibóia, is rich in conidial fungi. These fungi, as decomposers, are important for the dinamic of the studied ecosystem.

  18. Virtual reality and hallucination: a technoetic perspective

    Science.gov (United States)

    Slattery, Diana R.

    2008-02-01

    Virtual Reality (VR), especially in a technologically focused discourse, is defined by a class of hardware and software, among them head-mounted displays (HMDs), navigation and pointing devices; and stereoscopic imaging. This presentation examines the experiential aspect of VR. Putting "virtual" in front of "reality" modifies the ontological status of a class of experience-that of "reality." Reality has also been modified [by artists, new media theorists, technologists and philosophers] as augmented, mixed, simulated, artificial, layered, and enhanced. Modifications of reality are closely tied to modifications of perception. Media theorist Roy Ascott creates a model of three "VR's": Verifiable Reality, Virtual Reality, and Vegetal (entheogenically induced) Reality. The ways in which we shift our perceptual assumptions, create and verify illusions, and enter "the willing suspension of disbelief" that allows us entry into imaginal worlds is central to the experience of VR worlds, whether those worlds are explicitly representational (robotic manipulations by VR) or explicitly imaginal (VR artistic creations). The early rhetoric surrounding VR was interwoven with psychedelics, a perception amplified by Timothy Leary's presence on the historic SIGGRAPH panel, and the Wall Street Journal's tag of VR as "electronic LSD." This paper discusses the connections-philosophical, social-historical, and psychological-perceptual between these two domains.

  19. Purified Timothy grass pollen major allergen Phl p 1 may contribute to the modulation of allergic responses through a pleiotropic induction of cytokines and chemokines from airway epithelial cells.

    NARCIS (Netherlands)

    Röschmann, K.I.L.; van Kuijen, A.M.; Luiten, S.; Jonker, M.J.; Breit, T.M.; Fokkens, W.J.; Petersen, A.; van Drunen, C.M.

    2012-01-01

    By definition, allergens are proteins with the ability to elicit powerful T helper lymphocyte type 2 (Th2) responses, culminating in immunoglobulin (Ig)E antibody production. Why specific proteins cause aberrant immune responses has remained largely unanswered. Recent data suggest that there may be

  20. Purified Timothy grass pollen major allergen Phl p 1 may contribute to the modulation of allergic responses through a pleiotropic induction of cytokines and chemokines from airway epithelial cells

    NARCIS (Netherlands)

    Röschmann, K. I. L.; van Kuijen, A.-M.; Luiten, S.; Jonker, M. J.; Breit, T. M.; Fokkens, W. J.; Petersen, A.; van Drunen, C. M.

    2012-01-01

    By definition, allergens are proteins with the ability to elicit powerful T helper lymphocyte type 2 (Th2) responses, culminating in immunoglobulin (Ig)E antibody production. Why specific proteins cause aberrant immune responses has remained largely unanswered. Recent data suggest that there may be

  1. Brown, C. Timothy, When The AK-47s Fall Silent: Revolutionaries, Guerrillas, and the Dangers of Peace, Hoover Institution Press, Publication N. 476 Stanford University, 2000, 328p.; The Real Contra War: Highlander Peasant Resistance in Nicaragua, Norman,

    OpenAIRE

    Burgos, Elizabeth

    2005-01-01

    Se trata de un valioso aporte al estudio del controvertido tema del conflicto armado que sufrió Nicaragua tras la toma del poder por los sandinistas, y que dio término al proyecto revolucionario intentado por el FSLN tras la caída de Somoza. Ambas obras tratan, específicamente, del lapso de casi veinte años de enfrentamientos armados que vivió ese país durante los años 1979-1996 más conocido bajo el apelativo  acuñado por el campo adverso la Guerra de la “Contra”, que por su nombre real: Fuer...

  2. Methods in Forest Canopy Research, Edited by Margaret D. Lowman, Timothy D. Schowalter, Jerry F. Franklin, University of California Press, 2012; 221 Pages. Price: £41.95, ISBN 978-0520-27371-9

    Directory of Open Access Journals (Sweden)

    Shu-Kun Lin

    2013-01-01

    Full Text Available Poised between soil and sky, forest canopies represent a critical point of exchange between the atmosphere and the earth, yet until recently, they remained a largely unexplored frontier. For a long time, problems with access and the lack of tools and methods suitable for monitoring these complex bioscopes made canopy analysis extremely difficult. Fortunately, canopy research has advanced dramatically in recent decades. Methods in Forest Canopy Research is a comprehensive overview of these developments for explorers of this astonishing environment. The authors describe methods for reaching the canopy and the best ways to measure how the canopy, atmosphere, and forest floor interact. They address how to replicate experiments in challenging environments and lay the groundwork for creating standardized measurements in the canopy — essential tools for understanding our changing world.

  3. 78 FR 73898 - Operator Licensing Examination Standards for Power Reactors

    Science.gov (United States)

    2013-12-09

    [email protected] . Both of the Office of New Reactors; or Timothy Kolb, Office of Nuclear Reactor Regulation, U...: timothy.kolb@nrc.gov . SUPPLEMENTARY INFORMATION: I. Accessing Information and Submitting Comments A...

  4. 77 FR 17116 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2012-03-23

    ...), Michael R. Miller (PA), Jack L. Phippen (WI), Richard A. Purk (CA), Timothy M. Rearick (PA), Jeremy Simmons (MA), Jack A. Tidey (AK), Brian E. Quick (VA) and Timothy W. Work (NY) from the ITDM requirement...

  5. 78 FR 77772 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2013-12-24

    ... emissions of Black Carbon from international shipping --Review of relevant non-mandatory instruments as a... should contact the meeting coordinator, Mr. Timothy Brown, by email at timothy.m.brown@uscg.mil , by...

  6. Roy Macridis, Greek Politics at a Crossroads. What kind of socialism ?, Stanford, Hoover University Press, 1984, 72 p ” et “ Zafiris Tzannatos ed., Socialism in Greece, Aldershot, Brookfield, Gower, 1986, 210 p.

    OpenAIRE

    PAPADOPOULOS, Ioannis

    2005-01-01

    Il s'agit de deux ouvrages se proposant d'évaluer ­ à partir d'angles d'approche fort différents ­, la politique du PASOK au pouvoir en Grèce depuis les élections d'octobre 1981, qui lui ont permis de former le premier gouvernement socialiste du pays.

  7. Escala de medición del proceso de afrontamiento y adaptación de Callista Roy: una propuesta metodológica para su interpretación

    Directory of Open Access Journals (Sweden)

    Carolina Gutiérrez López

    2009-01-01

    Full Text Available El objetivo es proponer una nueva categorización, para precisarel grado de capacidad del proceso de afrontamiento y adapta-ción y conceptualizar sus estilos y estrategias. El estudio meto-dológico presenta una propuesta de cuatro categorías ordinales,en las cuales se utiliza el escalonamiento de Likert, deęnidascomo: baja, mediana, alta y muy alta capacidad de afrontamien-to. En cuanto a los resultados,se establecen cuatro categoríaspara cada factor global, conceptualizando cada categoría segúnestilos de afrontamiento: activos, pasivos o evitativos; dominiosde las estrategias de afrontamiento: cognitivo, conductual o com-portamental y emocional. Se concluye que las cuatro categoríasproporcionan información precisa del proceso de afrontamientoy adaptación del paciente para que la planeación y las interven-ciones de cuidado de enfermería sean más focalizadas a mejoraro reforzar estilos y estrategias para su adaptación.

  8. Probabilistic analysis and related topics

    CERN Document Server

    Bharucha-Reid, A T

    1979-01-01

    Probabilistic Analysis and Related Topics, Volume 2 focuses on the integrability, continuity, and differentiability of random functions, as well as functional analysis, measure theory, operator theory, and numerical analysis.The selection first offers information on the optimal control of stochastic systems and Gleason measures. Discussions focus on convergence of Gleason measures, random Gleason measures, orthogonally scattered Gleason measures, existence of optimal controls without feedback, random necessary conditions, and Gleason measures in tensor products. The text then elaborates on an

  9. Plaadid / Priit Hõbemägi

    Index Scriptorium Estoniae

    Hõbemägi, Priit, 1957-

    2006-01-01

    Uutest heliplaatidest George Benson "The Essential George Benson", Roy Orbison "The Essential Roy Orbisson", K.D. Lang "Reintaration", Blondie "Greatest Hits", Chris Isaak "Best Of Chris Isaak", Barry Manilov "The Essential Barry Manilow", ABBA "Greatest Hits"

  10. Semi Quantitative MALDI TOF for Antimicrobial Susceptibility Testing in Staphylococcus aureus

    Science.gov (United States)

    2017-08-31

    Semi- quantitative MALDI-TOF for antimicrobial susceptibility testing in Staphylococcus 1 aureus 2 3 4 Tucker Maxson,a Cheryl L. Taylor-Howell,a...Timothy D. Minoguea# 5 6 Diagnostic Systems Division, United States Army Medical Research Institute of Infectious 7 Disease, Fort Detrick, MD...USAa 8 9 Running Title: Quantitative MALDI for AST in S. aureus 10 #Address correspondence to Timothy D. Minogue, timothy.d.minogue.civ@mail.mil

  11. Triggers of Violence in New Religious Movements

    Science.gov (United States)

    2012-12-01

    71Brandon M. Stickney, All-American Monster: The Unauthorized Biography of Timothy McVeigh (New York: Prometheus Books, 1996), Kindle edition, 1503...and the one who was to rebuild the temple in Jerusalem just as Solomon had after his father’s death.85 Infighting between the two continued in... Biography of Timothy McVeigh. Amherst, NY: Prometheus Books, 1996. Kindle Edition. Toft, Monica, Daniel Philpott, and Timothy Shah. God’s Century. New

  12. Principles of maximally classical and maximally realistic quantum ...

    Indian Academy of Sciences (India)

    Principles of maximally classical and maximally realistic quantum mechanics. S M ROY. Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, India. Abstract. Recently Auberson, Mahoux, Roy and Singh have proved a long standing conjecture of Roy and Singh: In 2N-dimensional phase space, ...

  13. Tumor Grade

    Science.gov (United States)

    ... score. The American Joint Committee on Cancer recommends grouping Gleason scores into the following categories ( 1 ): Gleason ... factors, such as cancer stage and a patient’s age and general health, to develop a treatment plan ...

  14. Increased prostate cancer specific mortality following radical prostatectomy in men presenting with voiding symptoms—A whole of population study

    Directory of Open Access Journals (Sweden)

    Anthony D. Ta

    2015-09-01

    Conclusions: Primary Gleason pattern in Gleason 7 PC is an important prognosticator of survival. Our findings suggest that concomitant voiding symptoms should be considered in the work-up and treatment of PC.

  15. UNDERSTANDING SEVERE WEATHER PROCESSES THROUGH SPATIOTEMPORAL RELATIONAL RANDOM FORESTS

    Data.gov (United States)

    National Aeronautics and Space Administration — UNDERSTANDING SEVERE WEATHER PROCESSES THROUGH SPATIOTEMPORAL RELATIONAL RANDOM FORESTS AMY MCGOVERN, TIMOTHY SUPINIE, DAVID JOHN GAGNE II, NATHANIEL TROUTMAN,...

  16. Kidney injury molecule-1 and microalbuminuria levels in Zambian ...

    African Journals Online (AJOL)

    Kidney injury molecule-1 and microalbuminuria levels in Zambian population: biomarkers of kidney injury. Mildred Zulu, Trevor Kaile, Timothy Kantenga, Chisanga Chileshe, Panji Nkhoma, Musalula Sinkala ...

  17. Accession data for analysed Xestospongia testudinaria metatranscriptomes, supplement to: Jahn, Martin T; Markert, Sebastian M; Ryu, Taewoo; Ravasi, Timothy; Stigloher, Christian; Hentschel, Ute; Moitinho-Silva, Lucas (2016): Shedding light on cell compartmentation in the candidate phylum Poribacteria by high resolution visualisation and transcriptional profiling. Scientific Reports, 6, 35860

    KAUST Repository

    Jahn, Martin T; Markert, Sebastian M; Ryu, Tae Woo; Ravasi, Timothy; Stigloher, Christian; Hentschel, Ute; Moitinho-Silva, Lucas

    2016-01-01

    -CLEM) that enabled, to our knowledge for the first time, the identification of single cells within their complex microenvironment at electron microscopy resolution. Members of the candidate phylum Poribacteria, common and uncultivated symbionts of marine sponges

  18. Quantitative analysis of oyster larval proteome provides new insights into the effects of multiple climate change stressors, supplement to: Dineshram, R; Chandramouli, K; Ko, W K Ginger; Zhang, Huoming; Qian, Pei Yuan; Ravasi, Timothy; Thiyagarajan, Vengatesen (2016): Quantitative analysis of oyster larval proteome provides new insights into the effects of multiple climate change stressors. Global Change Biology, 22(6), 2054-2068

    KAUST Repository

    Dineshram, R; Chandramouli, Kondethimmanahalli; Ko, W K Ginger; Zhang, Huoming; Qian, Pei Yuan; Ravasi, Timothy; Thiyagarajan, Vengatesen

    2016-01-01

    survival bottleneck, which will be pressured by different anthropogenically induced climate change-related variables. Therefore, it is important to understand how metamorphosing larvae interact with emerging climate change stressors. To predict how larvae

  19. Evaluation of two grass pollen extracts for immunotherapy by serum determinations of specific IgE and IgG4 antibodies towards purified Timothy grass pollen allergens (Phl p 1, 2, 4, 5, 6, 7, 11, 12 in patients undergoing hyposensitization treatment

    Directory of Open Access Journals (Sweden)

    Renato Enzo Rossi

    2002-01-01

    Conclusions: These results indicate that grass pollen immunotherapy elicits an array of antibody specificities that reflect the allergen content and the potency of allergen extracts; this could be of pivotal importance to define optimal allergen extract doses.

  20. Accession data for analysed Xestospongia testudinaria metatranscriptomes, supplement to: Jahn, Martin T; Markert, Sebastian M; Ryu, Taewoo; Ravasi, Timothy; Stigloher, Christian; Hentschel, Ute; Moitinho-Silva, Lucas (2016): Shedding light on cell compartmentation in the candidate phylum Poribacteria by high resolution visualisation and transcriptional profiling. Scientific Reports, 6, 35860

    KAUST Repository

    Jahn, Martin T

    2016-01-01

    Assigning functions to uncultivated environmental microorganisms continues to be a challenging endeavour. Here, we present a new microscopy protocol for fluorescence in situ hybridisation-correlative light and electron microscopy (FISH-CLEM) that enabled, to our knowledge for the first time, the identification of single cells within their complex microenvironment at electron microscopy resolution. Members of the candidate phylum Poribacteria, common and uncultivated symbionts of marine sponges, were used towards this goal. Cellular 3D reconstructions revealed bipolar, spherical granules of low electron density, which likely represent carbon reserves. Poribacterial activity profiles were retrieved from prokaryotic enriched sponge metatranscriptomes using simulation-based optimised mapping. We observed high transcriptional activity for proteins related to bacterial microcompartments (BMC) and we resolved their subcellular localisation by combining FISH-CLEM with immunohistochemistry (IHC) on ultra-thin sponge tissue sections. In terms of functional relevance, we propose that the BMC-A region may be involved in 1,2-propanediol degradation. The FISH-IHC-CLEM approach was proven an effective toolkit to combine -omics approaches with functional studies and it should be widely applicable in environmental microbiology.

  1. Quantitative analysis of oyster larval proteome provides new insights into the effects of multiple climate change stressors, supplement to: Dineshram, R; Chandramouli, K; Ko, W K Ginger; Zhang, Huoming; Qian, Pei Yuan; Ravasi, Timothy; Thiyagarajan, Vengatesen (2016): Quantitative analysis of oyster larval proteome provides new insights into the effects of multiple climate change stressors. Global Change Biology, 22(6), 2054-2068

    KAUST Repository

    Dineshram, R

    2016-01-01

    The metamorphosis of planktonic larvae of the Pacific oyster (Crassostrea gigas) underpins their complex life-history strategy by switching on the molecular machinery required for sessile life and building calcite shells. Metamorphosis becomes a survival bottleneck, which will be pressured by different anthropogenically induced climate change-related variables. Therefore, it is important to understand how metamorphosing larvae interact with emerging climate change stressors. To predict how larvae might be affected in a future ocean, we examined changes in the proteome of metamorphosing larvae under multiple stressors: decreased pH (pH 7.4), increased temperature (30 °C), and reduced salinity (15 psu). Quantitative protein expression profiling using iTRAQ-LC-MS/MS identified more than 1300 proteins. Decreased pH had a negative effect on metamorphosis by down-regulating several proteins involved in energy production, metabolism, and protein synthesis. However, warming switched on these down-regulated pathways at pH 7.4. Under multiple stressors, cell signaling, energy production, growth, and developmental pathways were up-regulated, although metamorphosis was still reduced. Despite the lack of lethal effects, significant physiological responses to both individual and interacting climate change related stressors were observed at proteome level. The metamorphosing larvae of the C. gigas population in the Yellow Sea appear to have adequate phenotypic plasticity at the proteome level to survive in future coastal oceans, but with developmental and physiological costs.

  2. Keeping Our Eyes Open: Conducting Aerial Reconnaissance Without Space

    Science.gov (United States)

    2016-05-01

    TIMOTHY M. CULLEN (Date) ___________________________________ JAMES M. TUCCI (Date) iii DISCLAIMER The...in 2014/15, and USAF School of Advanced Air and Space Studies in 2015/16. v ACKNOWLEDGMENTS I would like to thank Colonel Timothy Cullen for...Admiral William Owens. In 1996 Owens described ISR as involving “sensor and reporting technologies associated with intelligence collection

  3. 76 FR 71370 - Silviu Ziscovici, M.D.; Decision and Order

    Science.gov (United States)

    2011-11-17

    ....; Decision and Order On December 10, 2010, Administrative Law Judge (ALJ) Timothy D. Wing, issued the... record in its entirety including the ALJ's recommended decision, I have decided to adopt the ALJ's... Administrative Law Judge Timothy D. Wing, Administrative Law Judge. This proceeding is an adjudication governed...

  4. Alpha-tocopherol and β-carotene in legume-grass mixtures as influenced by wilting, ensiling and type of silage additive

    DEFF Research Database (Denmark)

    Lindqvist, H; Nadeau, E; Jensen, Søren Krogh

    2012-01-01

    Effects of wilting, ensiling and type of additive on α-tocopherol and β-carotene contents in legume–grass mixtures were examined. Swards of birdsfoot trefoil + timothy (Bft + Ti), red clover + timothy (Rc + Ti) and red clover + meadow fescue (Rc + Mf) were harvested as a first regrowth in August...

  5. 77 FR 12883 - Announcement of Public Briefings on the Changes to the Labor Certification Process for the...

    Science.gov (United States)

    2012-03-02

    ... these steps: To join the March 14 Webinar, please go to: https://dol.webex.com/dol/onstage/g.php?d... 20 Webinar, please go to: https://dol.webex.com/dol/onstage/g.php?d=647498716&t=a&EA=erskine.timothy....webex.com/dol/onstage/g.php?d=644379778&t=a&EA=erskine.timothy%40dol.gov&ET...

  6. Ainuke püsiv asi on muutumine / Anneliis Aunapuu

    Index Scriptorium Estoniae

    Aunapuu, Anneliis

    2008-01-01

    Taani audiovideotehnikat disainivast firmast Jacob Jensen Design. Jacob Jenseni (sünd. 1926) asutatud büroo loomingut tutvustab tema poeg Timothy Jacob Jensen (sünd. 1962). Eesti disaini tasemest, Jaapani disainitoodangust. Esikaanel ja lk. B3 fotod Timothy Jacob Jensenist

  7. Technique Development Results for the Study of a Novel Dexamethasone Impregnated Bandage Contact Lens in a Rabbit Model After Photorefractive Keratectomy

    Science.gov (United States)

    2017-10-22

    PRK Inflammation in a Rabbit Model Timothy A. Soekenl, Michael Merkley!, Wesley Brundridgel, Gary Legaultl, Matthew Caldwelll, Joseph Ciolino2...7 .0 Dexamethasone Impregnated Contact Lenses in the Treatment of Post- PRK Inflammation · in a Rabbit Model Timothy A. Soeken 1, Michael Merkley1

  8. Pavel Aleksadrovič Florenskij's method of discerning spiritual truth ...

    African Journals Online (AJOL)

    The article also provides an intertextual reading of Florenskij's Pillar to argue that its context is 1 Timothy 3:14-16. It then analyses the similarities between the context of 1 Timothy and that of The Pillar. As they fall within a period during which particular churches faced certain challenges, both texts call for discernment of the ...

  9. Book Review: "Indigenous Peoples of the British Dominions and the ...

    African Journals Online (AJOL)

    Book Review: "Indigenous Peoples of the British Dominions and the First World War"by Timothy C. Winegard. ... Timothy Winegard saw active duty in the Canadian Reserve Force from 2001 to 2010 and served on detachment duty to the British Army for a two-year period. He obtained various academic degrees from 1999 ...

  10. Identifying Local Benefits of Early Childhood Development Programs Using Regional Modeling

    Science.gov (United States)

    Temple, Judy A.; Rolnick, Arthur J.

    2012-01-01

    This article presents a review of "Investing in Kids: Early Childhood Programs and Local Economic Development" by Timothy J. Bartik. Timothy Bartik's timely book contributes to an important conversation about the role of government in promoting investments in children in the years before traditional public schooling typically begins. Until…

  11. Evaluating Lignite-Derived Products (LDPs) for Agriculture - Does Research Inform Practice?

    Science.gov (United States)

    Patti, Antonio; Rose, Michael; Little, Karen; Jackson, Roy; Cavagnaro, Timothy

    2014-05-01

    . However, these growth benefits subsequently diminished over time. Insignificant growth benefits were observed for lucerne. The analysis of the literature and our own work indicates that it is difficult to account for all the possible variables where research is used to inform land management practices. Assisting farmers to conduct localised research in cooperative ventures is likely to bring about the best outcomes where site-specific research directly informs land management practices. 1. Michael T. Rose, Antonio F. Patti, Karen R. Little, Alicia L. Brown, W. Roy Jackson, Timothy R. Cavagnaro, A Meta-Analysis and Review of Plant-Growth Response to Humic Substances: Practical Implications for Agriculture, Advances in Agronomy, 2013, 124, 37-89

  12. PSA Density as a prognostic factor in prostate cancer patients treated with radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Lankford, Scott; Pollack, Alan; Zagars, Gunar K

    1995-07-01

    of 7, and 34 with scores of 8-10. Only 3 patients had elevated prostatic acid phosphatase values (>0.8 mU/ml, Roy enzymatic method). Biochemical failure was defined as two consecutive increases in follow-up PSAs, one increase by a factor >1.5 or an absolute increase of >1 ng/ml. Results: PSAD correlated with several prognostic factors including Stage (p=0.007, Kendall correlation), Gleason score (p=0.05), PSAL (p<0.001), and pretreatment prostatic acid phosphatase (PAP, p=0.001). Similar correlations were observed when the distributions of patients grouped by PSAD were compared to that with the other factors. Grouped PSAD was associated with PSAL (P<0.0001), chi-square, Stage (p=0.0002), PAP (p=0.002), and Gleason score (p=0.09). The relationship of these factors to 4 yr actuarial LC revealed that PSAD and PSAL were prognostic (p<0.0001, trended log-rank). In terms of FFBF, PSAL, PSAD, PAP, and Stage were significantly associated with outcome. In contrast, Stage, Gleason score, and PAP were the only factors predictive of FFDM. Thus, the univariate analyses revealed that PSAD appeared to be nearly identical to PSAL in predicting LC and FFBF. Multivariate analyses using Cox proportional hazards models were then performed to determine if PSAD provided prognostic information independent of PSAL. For these tests, PSAL was grouped into 3 groups ({<=}4, >4 {<=}20, and >20 ng/ml) since this grouping resulted in the strongest correlations. PSAD was the only independently significant factor prognostic of LC, and was also prognostic of FFBF and FFAF along with PSAL. In contrast, neither PSAD or PSAL were prognostic for FFDM; Stage, PAP, and Gleason score were the only significant covariates using this endpoint. Conclusions: PSAD was highly correlated with actuarial outcome and was independent of PSAL. PSAD was particularly useful in subdividing patients with PSALs of between 4-20 ng/ml in terms of FFBF and FFAF. Thus, PSAD should be routinely calculated in patients who are

  13. and the quality of silage

    Directory of Open Access Journals (Sweden)

    Liisa Syrjälä-Qvist

    1984-09-01

    Full Text Available Five silages having different proportions of red clover and timothy (100/0, 75/25, 50/50, 25/75 and 0/100 were preserved in five glass-fibre silos of 0.4 m 3. Chopped red clover and timothy were mixed during ensiling and preserved with AIV II solution (80 % formic acid and 2 % orthophosphoric acid, applied at the rate of 6 l/1000kg fresh material. The timothy sward was fertilized with 100kg N/ha and the red clover with 15kg N/ha. The dry matter content in red clover was 14.5 % and in timothy 18.6%, and the crude protein content of DM 22.9 % and 11.5 %, respectively. True protein formed 75—76 % of crude protein in both herbages and the proportion of watersoluble N in total N was 32 % in red clover and 36 % in timothy. The rumen degradability of protein during the first two hours was under 10 % in both herbages; after 18 and 24h ours it was 76 % and 87 % in red clover, and 65 % and 70 % in timothy. In red clover the contents of lysine, methionine and cysteine were 5.7 g, 0.4 g and 0.9 g/16 g N, respectively, the corresponding values for timothy being 4.8 g, 0.7 g and 1.4g/16 g N. In red clover the content of water-soluble carbohydrates was 10.6 % of DM and in timothy 16.5 %; the contents of plant acids were 6.7 % and 3.5 % of DM, respectively. Red clover contained 10.9g Ca/kg DM and timothy 3.1 g Ca. The total amount of inorganic constituents was also higher in red clover than in timothy. Although the chemical composition of red clover was less suitable for ensiling than the composition of timothy, the quality of all the silages was good. During ensiling the decrease in the proportion of true protein in crude protein and the increase in the proportion of watersoluble N in total N were smaller in red clover than in timothy silage. These changes were reflected in the ruminal protein degradation, which seemed to be slower when they were small. The amino acid profile of the protein did not alter during ensiling. The ensiling losses were higher in

  14. ANALISIS EKSPRESI TRANSPORTER ZINK (ZNT-1 SEBAGAI FAKTOR PROGNOSIS ADENOKARSINOMA PROSTAT

    Directory of Open Access Journals (Sweden)

    Feriandri Utomo

    2016-04-01

    Full Text Available Penurunan kadar Zink (Zn berkorelasi dengan peningkatan skor Gleason adenokarsinoma prostat, dan rendahnya Caspase-3 (eksekutor apoptosis. Ekspresi ZIP-1 (importer Zn turun pada adenokarsinoma prostat. Korelasi ZnT-1 (eksporter Zn, ZIP-1 dan Caspase-3 diduga berpotensi menjadi faktor prognosis adenokarsinoma prostat. Penelitian ini bertujuan menganalisis korelasi ekspresi ZnT-1, ZIP-1, Caspase-3 dan skor Gleason adenokarsinoma prostat. Studi retrospektif analitik potong lintang dilakukan pada 14 kasus adenokarsinoma prostat skor Gleason ≤7 dan 16 kasus dengan skor Gleason >7. Ekspresi ZnT-1 dinilai dengan metode imunohistokimia. Analisis tambahan dilakukan untuk melihat korelasi ZnT-1, ZIP-1 dan Caspase-3. Hasil penelitian didapatkan ZnT-1 pada skor Gleason >7 lebih rendah daripada skor Gleason ≤7. ZnT-1 berkorelasi dengan skor Gleason. ZnT-1 berkorelasi dengan ZIP-1 pada skor Gleason >7. ZIP-1 berkorelasi dengan Caspase-3 pada skor Gleason ≤7. ZIP-1 berkorelasi kuat dengan Caspase-3 pada skor Gleason 8. Penelitian ini menyimpulkan rendahnya ekspresi ZnT-1 dan ZIP-1 berpotensi menjadi faktor prognosis adenokarsinoma prostat.

  15. Identification et prévention du risque suicidaire chez les personnes âgées résidant en EMS: une revue de la littérature soutenue par le modèle de l'adaptation de C. Roy : travail de Bachelor

    OpenAIRE

    Brandtner, Yasmina; Payré, Marie; Peyrot, Marion; Vulliet, Corentine; Maupetit, Christine

    2015-01-01

    Introduction. Le suicide est un problème majeur en santé publique en Suisse, où le taux de suicide est élevé. En parallèle, de nombreux enjeux sont liés au vieillissement de la population, parmi lesquels la demande croissante de soins en résidence médicalisée. Il existe peu de données sur les comportements suicidaires dans les nursing homes. Le but de cette revue synthétique de la littérature est de décrire l’épidémiologie du phénomène du suicide en nursing home, les facteurs de risques et le...

  16. The Role of IDO in Muc1 Targeted Immunotherapy

    Science.gov (United States)

    2013-01-01

    Besmer*, Teresa L. Tinder , Lopamudra Das Roy, Joseph Lustgarten, Sandra J. Gendler, Pinku Mukherjee Intratumoral Delivery of CpG-Conjugated Anti...3073-87. Epub 2012 Jan 11. PMID: 22238308 3. Mahnaz Sahraei , Lopamudra Das Roy , Jennifer Curry , Teresa Tinder , Sritama Nath , Dahlia M...10.1038/onc.2011.651 4. Dahlia M. Besmer , Dr. Jennifer M. Curry , Dr. Lopamudra D. Roy , Ms. Teresa L. Tinder , Ms. Mahnaz M. Sahraei , Dr

  17. 77 FR 37710 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Science.gov (United States)

    2012-06-22

    ... in your comment to withhold your personal identifying information from public review, we cannot..., 1611 Roy Acuff Pl., Nashville, 12000420 WASHINGTON Clark County Kiggins Theater, (Movie Theaters in...

  18. Popmuusika / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2006-01-01

    Uutest heliplaatidest Phoenix "It's Never Been Like That", Opium Flirt "Vibratiooni Sessioon", Mobb Deep "Blood Money", Roy Orbison "Thev Essential", Depoo "Amazing", Bardi Johannsson "Haxan", Honeymunch "Bunch"

  19. Bilateral ovarian serous cystadenocarcinoma in a teenager

    African Journals Online (AJOL)

    abp

    2017-09-12

    Sep 12, 2017 ... &Corresponding author: Timothy Abiola Oluwasola, Department of Obstetrics and Gynaecology, ... in women accounting for 151,900 deaths in 2012 [1]. .... presentation in UCH which would have positively contributed to her.

  20. Congenital hearing loss. Is CT enough?

    African Journals Online (AJOL)

    Mahmoud Agha

    2014-01-24

    Jan 24, 2014 ... children have potential impact on child educational, cognitive and social development. .... nerstone for management planning. It guides the selection of ..... 7. Timothy C.Hain. Congenital deafness. http://www.dizziness-and-.

  1. Cellular computing

    National Research Council Canada - National Science Library

    Amos, Martyn

    2004-01-01

    ... 120 Ron Weiss, Thomas F. Knight Jr., and Gerald Sussman 8 The Biology of Integration of Cells into Microscale and Nanoscale Systems 148 Michael L. Simpson, Timothy E. McKnight, Michael A. Guillor...

  2. Love, lust and the emotional context of multiple and concurrent ...

    African Journals Online (AJOL)

    Love, lust and the emotional context of multiple and concurrent sexual partnerships among young Swazi adults. Allison Ruark, Lunga Dlamini, Nonhlanhla Mazibuko, Edward C Green, Caitlin Kennedy, Amy Nunn, Timothy Flanigan, Pamela J Surkan ...

  3. 76 FR 7625 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2011-02-10

    ... exempts, Thomas H. Adams, Jr., Charlie A. Barner, Charles G. Beasley, Philp M. Carr, Timothy D. Cochran..., Darwin D. Roberts, Robert A. Roskamp, David N. Studebaker, Danny J. Watson, Robert L. Wenzel, David A...

  4. Cancer Prevention in the Precision Medicine Era | Division of Cancer Prevention

    Science.gov (United States)

    Speaker | Timothy R. Rebbeck, PhD will present "Cancer Prevention in the Precision Medicine Era" on March 20, 2018, from 11:00 am - 12:00 pm at the NCI Shady Grove Campus. Learn more about this lecture.

  5. Padvinders, Pandu, Pramuka: Youth and State in the 20th Century ...

    African Journals Online (AJOL)

    seriane.camara

    2011-12-01

    Dec 1, 2011 ... learn and develop good character, trustworthiness, discipline, intelligence, ...... the Muhammadiyah seized it as an opportunity to re-activate Hizbul Wathan .... Parsons, Timothy H., 2001, 'No More English than the Postal ...

  6. Uurimist toimetavad Wolfe ja Goodwin / Katrin Mõttus

    Index Scriptorium Estoniae

    Mõttus, Katrin

    2003-01-01

    Sari filme - Rex Stout'i detektiivromaanide ekraniseeringud, kus peategelaseks eradetektiiv Nero Wolfe (Maury Chaykin) koos oma noore abilise Archie Goodwiniga (Timothy Hutton) : Ameerika Ühendriigid 2001-2002

  7. Mõrvade üleeuroopaline dimensioon / Karsten Brüggemann ; saksa keelest tõlkinud Tea Vassiljeva

    Index Scriptorium Estoniae

    Brüggemann, Karsten, 1965-

    2011-01-01

    Arvustus: Naimark, Norman M. Stalin's genocides. Princeton (N.J.) ; Oxford : Princeton University Press, 2010 ; Snyder, Timothy. Bloodlands : Europe between Hitler and Stalin. New York : Basic Books, c2010

  8. 77 FR 74273 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-12-13

    ... (SD) Terry L. Anderson (PA) Sammy J. Barada (NE) Timothy Bradford (TN) Cody W. Cook (OK) Marvin R...) Thomas L. Oglesby (GA) Garrick Pitts (AR) Jonathan C. Rollings (IA) Preston S. Salisbury (MT) Victor M...

  9. Defense AT&L (Volume 36, Number 1, January-February 2007)

    National Research Council Canada - National Science Library

    2007-01-01

    ...: I," -- by Timothy S. Kroecker -- Organizations must accept that individuals receive technical training for high-responsibility program management positions but may lack the depth of experience or leadership required for effectiveness...

  10. Acute Pancreatitis and Pregnancy

    Science.gov (United States)

    ... Pancreatitis Acute Pancreatitis and Pregnancy Acute Pancreatitis and Pregnancy Timothy Gardner, MD Acute pancreatitis is defined as ... pancreatitis in pregnancy. Reasons for Acute Pancreatitis and Pregnancy While acute pancreatitis is responsible for almost 1 ...

  11. Autoantibodies

    Science.gov (United States)

    ... Antibodies Beta-2 Glycoprotein 1 Antibodies Antiphospholipid Antibodies (APA) Lupus anticoagulants (LA) Endocrine/metabolic system Diabetes-related ... Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO. What ...

  12. Taxonomic and phylogenetic utility of variation in advertising calls of ...

    African Journals Online (AJOL)

    Taxonomic and phylogenetic utility of variation in advertising calls of francolins and spurfowls (Galliformes: Phasianidae). Tshifhiwa G. Mandiwana-Neudani, Rauri C.K. Bowie, Martine Hausberger, Laurence Henry, Timothy M. Crowe ...

  13. T3 (Triiodothyronine) Test

    Science.gov (United States)

    ... Reviews Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition]. Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and ... Medical Encyclopedia [On-line information]. Available online at http:// ...

  14. Database Development for Ocean Impacts: Imaging, Outreach, and Rapid Response

    Science.gov (United States)

    2012-09-30

    Timothy Stanton Woods Hole Oceanographic Institution Acoustics PUBLICATIONS 33 Refereed, Published Articles Supported through this award 2012...Laboratory for Translational Auditory Research, Journal of the American Academy of Audiology , vol.23, Issue 6, New York, p.422-437. [published

  15. Blood Typing

    Science.gov (United States)

    ... article The Universe of Genetic Testing: The Basics , Identity Testing , and Parentage Testing . What does the test ... Pagana, Kathleen D. & Pagana, Timothy J. (© 2006). Mosby's Manual of Diagnostic and Laboratory Test 3rd Edition: Mosby, ...

  16. Meie "oma" Unabomber - kes ta on? / Valdek Kiiver

    Index Scriptorium Estoniae

    Kiiver, Valdek

    2005-01-01

    1995. a. tabasid USA võimud riiki 17 aastat kirjapommidega terroriseerinud kurjategija, keda kutsuti Unabomberiks. Theodore Kaczynsky (Unabomberi) tegevusest ja tabamisest. Vt. samas: Oklahoma, 1995. Timothy McVeigh kui Oklahoma föderaalkohtuhoones plahvatuse organiseerija

  17. Chemotherapy Side Effects: A Cause of Heart Disease?

    Science.gov (United States)

    ... Can chemotherapy side effects increase the risk of heart disease? Answers from Timothy J. Moynihan, M.D. Chemotherapy side effects may increase the risk of heart disease, including weakening of the heart muscle (cardiomyopathy) and ...

  18. PÖFFil ärkab ellu ooperifantoom / Immo Mihkelson

    Index Scriptorium Estoniae

    Mihkelson, Immo, 1959-

    2004-01-01

    Tallinna VIII Pimedate Ööde Filmifestivali avalöögiks on kontsertlinastus USA 1925.a. õudusfilmist "Ooperifantoom", mida saadab Carl Davise muusika Vanemuise Sümfooniaorkestri esituses Timothy Redmondi juhatusel. Lisatud "Fakte PÖFFist"

  19. Festival lähetab maailma eri nurkadesse / Kerttu Jänese

    Index Scriptorium Estoniae

    Jänese, Kerttu, 1946-

    2008-01-01

    V dokumentaal- ja antropoloogiliste filmide festival "Maailmafilm" algab 24. märtsil Eesti Rahva Muuseumi näitusemajas Tartus. Kavas on ka kolm eriprogrammi: kirjanikud filmis, klassiku Timothy Aschi looming ja 8 filmi inimesest linnas

  20. Gastrointestinal symptoms among swimmers following rain events at a beach impacted by urban runoff

    Science.gov (United States)

    Gastrointestinal symptoms among swimmers following rain events at a beach impacted by urban runoff Timothy J. Wade, Reagan R. Converse, Elizabeth A. Sams, Ann H. Williams, Edward Hudgens, Alfred P. Dufour Gastrointestinal symptoms among swimmers have been associated with fecal ...

  1. Viie distsipliini rakendamise käsiraamat loob tervikpildi / Toomas Kink

    Index Scriptorium Estoniae

    Kink, Toomas

    2009-01-01

    Õppivaks organisatsiooniks saab kujuneda ainult meeskondliku ühistegevuse kaudu. Tutvustatakse raamatut: Õppiv kool / Peter Senge, Nelda Cambron-McCabe, Timothy Lucas ... [jt.]. Tartu : Atlex, 2009

  2. Design and Analysis of an Attitude Determination and Control Subsystem (ADCS) for AFIT’s 6U Standard Bus

    Science.gov (United States)

    2014-03-27

    solenoid in Eq. 3.2 [49]. M = nIA (3.2) where n is the number of turns of the wire, I is the current going through the wire, and A is the cross...Bldg 497 Kirtland AFB, NM 87117 Timothy J. Shuck, Capt, USAF, ( 505 ) 853-4513, timothy.shuck@kirtland.af.mil AFRL/RVES 12. DISTRIBUTION / AVAILABILITY

  3. Understanding, Classifying, and Selecting Environmentally Acceptable Hydraulic Fluids

    Science.gov (United States)

    2016-08-01

    traditional mineral oil; therefore, the life cycle costs over time may be reduced . REPLACEMENT OF EXISTING HYDRAULIC FLUIDS: Hydraulic fluids in existing...properly maintaining the fluid can extend the time interval between fluid changes, thus reducing the overall operating cost of the EA hydraulic fluid. It...Environmentally Acceptable Hydraulic Fluids by Timothy J. Keyser, Robert N. Samuel, and Timothy L. Welp INTRODUCTION: On a daily basis, the United States Army

  4. From Power Projection To Power Protection: Revitalizing Conventional Deterrence In NATO

    Science.gov (United States)

    2016-06-01

    Col TIMOTHY M. CULLEN _____________________________ Dr. RICHARD R. MULLER ii DISCLAIMER The conclusions and opinions expressed in...ACKNOWLEDGMENTS I would like to thank my thesis advisor, Col Timothy Cullen , who helped me structure my rough ideas within the framework of...a neighboring country (as in the case of Iraq’s seizure of Kuwait) is extremely difficult to reverse. Alexander George and William Simons Old

  5. Space Theory and Strategy: War From the High Ground Down

    Science.gov (United States)

    2016-06-01

    M.V. “COYOTE” SMITH (Date) __________________________________________ COLONEL TIMOTHY CULLEN (Date) iii...reader, Colonel Timothy Cullen , I would like to express my gratitude for the insightful suggestions to this work. To the ultimate sounding board... William L. Shelton, “Military Space: A Strategic Crossroad,” Air & Space Power Journal (September-October 2013): 5-6, War From the High Ground Down

  6. A Tale of One China: How and Why Has the Efficacy of United States Arms Sales to Taiwan Changed Since 1990

    Science.gov (United States)

    2016-05-01

    Col Timothy M. Cullen , Ph.D. Date ii DISCLAIMER The conclusions and opinions expressed in this document are those...thesis. I am also greatly indebted to Colonel Timothy Cullen , Ph.D., and Dr. Mark Conversino, for their guidance and mentorship, not only on this...http://articles.latimes.com/2001/apr/22/news/ mn-54114. 7 William Lowther, “Taiwan Still a Top Buyer of US Arms,” Taipei Times, 22 December 2011

  7. Operations Events Census Report: Volume IV. 1981 through 1985. Sanitized Version.

    Science.gov (United States)

    1991-04-01

    SMITH, BRADY F. 0837 SMITH, BRUCE E. 0638 SMITH, CHARLOTT W. 0837 SMITH, CLIFFORD H. 0869 SMITH, COLIN C. 0483 SMITH, DARWIN 0599 SMITH, DAVID L... COLIN A. 097! MOORE, EDDIE L. 06491 MOORE, GERALD J. 0738 MORACA, STEPHEN L. 0837 MORAN, KEVIN 0599 MORAN, MARY SHANKS 0861 MORAVEC, TIMOTHY 0599...DRIESBACH, ROBERT A. 0599 DROTLEFF, JAMES E. 0746 DRUMMOND, VEE DEE 0636 DRURY , TIMOTHY E. 0920 DUANE, DENNIS 0636 DUBARTON, ANNE EVELYN 0918 DUENAS

  8. Adaptation of Physiological and Cognitive Workload via Interactive Multi-modal Displays

    Science.gov (United States)

    2014-05-28

    peer-reviewed journals (N/A for none) 09/07/2013 Received Paper 8.00 James Merlo, Joseph E. Mercado , Jan B.F. Van Erp, Peter A. Hancock. Improving...08, . : , Mr. Joseph Mercado , Mr. Timothy White, Dr. Peter Hancock. Effects of Cross-Modal Sensory Cueing Automation Failurein a Target Detection Task...fields:...... ...... ...... ...... ...... PERCENT_SUPPORTEDNAME FTE Equivalent: Total Number: Discipline Joseph Mercado 0.50 Timothy White 0.50 1.00 2

  9. AM2 Modified 2-1 Lay Pattern Evaluation under F-15E Traffic

    Science.gov (United States)

    2015-08-01

    te ch ni ca l a nd S tr uc tu re s La bo ra to ry Lyan Garcia, Julie Heiser , Timothy W. Rushing, Chase T. Bradley, Jeb S. Tingle, and Craig...Engineer Research and Development Center 3909 Halls Ferry Road Vicksburg, MS 39180-6199 Julie Heiser Applied Research Associates 430 West 5th Street...5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Lyan Garcia, Julie Heiser , Timothy W. Rushing, Chase T. Bradley, Jeb S. Tingle, and Craig A

  10. Governmental Control on Jurnalistic Practice in 'Pseudo-democratic' Malaysia and Singapore or Big Company Control on Journalistic Practice in 'Established-democratic' Australia: Which is Worse and Where Are the Parallesl

    OpenAIRE

    Sinclair, Elizabeth

    2015-01-01

    Amanda Whiting and Timothy Marjoribanks argued in their chapter Media professional’s perceptions of defamation and other constraints upon news reporting in Malaysia and Singapore[1]that Malaysia and Singapore experience, due to a number of factors, restricted media freedom - many of these factors relating to the semi-democratic nature of Malaysian and Singaporean government. [1]Amanda Whiting and Timothy Marjoribanks, ‘Media Professionals' Perceptions of Defamation and other Constraints u...

  11. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. Tapta Kanchan Roy. Articles written in Journal of Chemical Sciences. Volume 121 Issue 5 September 2009 pp 805-810. Effective harmonic oscillator description of anharmonic molecular vibrations · Tapta Kanchan Roy M Durga Prasad · More Details Abstract Fulltext PDF.

  12. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. D Roy. Articles written in Sadhana. Volume 29 Issue 6 December 2004 pp 589-604. Techniques based on genetic algorithms for large deflection analysis of beams · Rajesh Kumar L S Ramachandra D Roy · More Details Abstract Fulltext PDF. A couple of non-convex search strategies, based on ...

  13. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Recently Auberson, Mahoux, Roy and Singh have proved a long standing conjecture of Roy and Singh: In 2-dimensional phase space, a maximally realistic quantum mechanics can have quantum probabilities of no more than + 1 complete commuting cets (CCS) of observables coexisting as marginals of one positive ...

  14. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. U N Roy. Articles written in Sadhana. Volume 26 Issue 3 June 2001 pp 213-225. An indigenously developed electronic control system for Langmuir-Blodgett film deposition set-up · C P Navathe B L Dashora Archana Jaiswal D S Thakur U N Roy L M Kukreja · More Details Abstract Fulltext PDF.

  15. $\\pi$ $\\pi$ theories

    CERN Document Server

    Basdevant, J L

    1972-01-01

    Reviews the structure of pion pion theories, in particular Roskies' sum rules, Martin's inequalities, Roy's relations, Roy's equations, Atkinsons Program, the Chew-Mandelstam equations, the Bootstrap phenomenological analyses, current algebra input, FESR bootstrap Lovelace Veneziano model and the Pade approximation. (63 refs).

  16. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. S Roy. Articles written in Bulletin of Materials Science. Volume 25 Issue 6 November 2002 pp 513-515. Improved zinc oxide film for gas sensor applications · S Roy S Basu · More Details Abstract Fulltext PDF. Zinc oxide (ZnO) is a versatile material for different commercial ...

  17. Oversight Hearing on Drug Abuse Education Programs. Hearing before the Subcommittee on Elementary, Secondary, and Vocational Education of the Committee on Education and Labor. House of Representatives, 101st Congress, 2nd Session (Vancouver, Washington, September 6, 1990).

    Science.gov (United States)

    Congress of the U.S., Washington, DC. House Committee on Education and Labor.

    The text of an oversight hearing on Drug Abuse Resistance Education (DARE) programs is presented in this document. Introductory statements by Representatives Jolene Unsoeld and Dale E. Kildee are presented. Testimony by these witnesses is included: (1) Roy Bondurant, student, and Roy "Skip" Bondurant, parent, Tenino, Washington; (2) Paul…

  18. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Chemical Sciences. Sujit Roy. Articles written in Journal of Chemical Sciences. Volume 114 Issue 4 August 2002 pp 277-283. Transition metal catalysed Grignard-like allylic activation across tetragonal tin(II) oxide · Pradipta Sinha Moloy Banerjee Abhijit Kundu Sujit Roy · More Details Abstract ...

  19. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science. Manideepa Roy Choudhury. Articles written in Journal of Earth System Science. Volume 125 Issue 5 July 2016 pp 1033-1040. Deformation of footwall rock of Phulad Shear Zone, Rajasthan: Evidence of transpressional shear zone · Manideepa Roy Choudhury Subhrajyoti ...

  20. Untitled

    Indian Academy of Sciences (India)

    A low cost iaser Raman spectrometer is described in the present study. The signal collection and ... E S. Raja Gopal and Prof. R. Srinivasan. The financial help from the Department of Science and Technology, New. Delhi, is especially acknowledged. References. Bansal M L, Roy T R, Sahni V C and Roy A P 1976 Indian.

  1. Prescription Stimulants and the Development of Post-Traumatic Stress Disorder among U.S. Service Members

    Science.gov (United States)

    2013-08-13

    Medina-Torne, M.P.H.; Anna Nagel, M.P.H.; Roy Nesbitt, M.A.; Christopher Phillips, M.D., M.P.H.; Roy Nesbitt, M.A.; Toni Rush, M.P.H.; Kari Sausedo...RJ, Robbins BW, Caiola E, Joynt M, Halterman JS. Prescribing of controlled medications to adolescents and young adults in the United States

  2. A Novel Association and Therapeutic Targeting of Neuropilin-1 and MUC1 in Pancreatic Cancer

    Science.gov (United States)

    2015-12-01

    be potentially translated to human clinical trials. Other Achievements References 1. Besmer DM, Curry JM, Roy LD, Tinder TL, Sahraei M, Schettini J...containing protein tyrosine phosphatase 2. J Cell Sci 2009, 122(Pt 18):3385-3392. 4. Roy LD, Sahraei M, Subramani DB, Besmer D, Nath S, Tinder TL, Bajaj E

  3. Evaluate the Mechanism of Enhanced Metastasis Induced by Arthritis

    Science.gov (United States)

    2012-09-01

    Genes that mediate breast ca ncer metastasis to lung . Nature 2005, 436(7050):518-524. 6. Das Roy L, Pathangey L, Tinder T, Schettini J, Gruber H...7. Das Roy L, Ghosh S, Pathangey LB, Tinder TL, Gruber HE, Mukherjee P: Collagen induced arthritis increases s econdary metastasis in MMTV-PyV

  4. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. D P Roy. Articles written in Pramana – Journal of Physics. Volume 54 Issue 1 January 2000 pp 3-20. Neutrino mass and oscillation: An introductory review · D P Roy · More Details Abstract Fulltext PDF. After a brief introduction to neutrino mass via the see-saw model I discuss ...

  5. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Dhiranjan Roy. Articles written in Resonance – Journal of Science Education. Volume 19 Issue 5 May 2014 pp 446-465 General Article. Projectile Motion with Quadratic Damping in a Constant Gravitational Field · Chandra Das Dhiranjan Roy · More Details ...

  6. Book Reviews

    Directory of Open Access Journals (Sweden)

    Ann Kumar

    1999-10-01

    Linguistic Studies of Indonesian and Other Languages in Indonesia 38.] - Ch. F. van Fraassen, R.Z. Leirissa, Halmahera Timur dan Raja Jailolo; Pergolakan sekitar Laut Seram awal abad 19. Jakarta: Balai Pustaka, 1996, xiv + 256 pp. - Frances Gouda, Denys Lombard, Rêver l’Asie; Exotisme et littérature coloniale aux Indes, an Indochine et en Insulinde. Paris: Éditions de l’École des Hautes Études en Sciences Sociales, 1993, 486 pp., Catherine Champion, Henri Chambert-Loir (eds. - Hans Hägerdal, Timothy Lindsey, The romance of K’tut Tantri and Indonesia; Texts and scripts, history and identity. Kuala Lumpur: Oxford University Press, 1997, xix + 362 + 24 pp. - Renee Hagesteijn, Ina E. Slamet-Velsink, Emerging hierarchies; Processes of stratification and early state formation in the Indonesian archipelago: prehistory and the ethnographic present. Leiden: KITLV Press, 1995, ix + 279 pp. [VKI 166.] - David Henley, Victor T. King, Environmental challenges in South-East Asia. Richmond: Curzon Press, 1998, xviii + 410 pp. [Nordic Institute of Asian Studies, Man and Nature in Asia Series 2.] - C. de Jonge, Ton Otto, Cultural dynamics of religious change in Oceania. Leiden: KITLV Press, 1997, viii + 144 pp. [VKI 176.], Ad Boorsboom (eds. - C. de Jonge, Chris Sugden, Seeking the Asian face of Jesus; A critical and comparative study of the practice and theology of Christian social witness in Indonesia and India between 1974 and 1996. Oxford: Regnum, 1997, xix + 496 pp. - John N. Miksic, Roy E. Jordaan, In praise of Prambanan; Dutch essays on the Loro Jonggrang temple complex. Leiden: KITLV Press, 1996, xii + 259 pp. [Translation Series 26.] - Marije Plomp, Ann Kumar, Illuminations; The writing traditions of Indonesia; Featuring manuscripts from the National Library of Indonesia. Jakarta: The Lontar Foundation, New York: Weatherhill, 1996., John H. McGlynn (eds. - Susan de Roode, Eveline Ferretti, Cutting across the lands; An annotated bibliography on natural resource management

  7. Thresholds, injury, and loss relationships for thrips in Phleum pratense (Poales: Poaceae).

    Science.gov (United States)

    Reisig, Dominic D; Godfrey, Larry D; Marcum, Daniel B

    2009-12-01

    Timothy (Phleum pratense L.) is an important forage crop in many Western U.S. states. Marketing of timothy hay is primarily based on esthetics, and green color is an important attribute. The objective of these studies was to determine a relationship between arthropod populations, yield, and esthetic injury in timothy. Economic injury levels (EILs) and economic thresholds were calculated based on these relationships. Thrips (Thripidae) numbers were manipulated with insecticides in small plot studies in 2006, 2007, and 2008, although tetranychid mite levels were incidentally flared by cyfluthrin in some experiments. Arthropod population densities were determined weekly, and yield and esthetic injury were measured at each harvest. Effects of arthropods on timothy were assessed using multilinear regression. Producers were also surveyed to relate economic loss from leaf color to the injury ratings for use in establishing EILs. Thrips population levels were significantly related to yield loss in only one of nine experiments. Thrips population levels were significantly related to injury once before the first annual harvest and twice before the second. Thrips were the most important pest in these experiments, and they were more often related to esthetic injury rather than yield loss. EILs and economic thresholds for thrips population levels were established using esthetic injury data. These results document the first example of a significant relationship between arthropod pest population levels and economic yield and quality losses in timothy.

  8. Retraction and expansion of flock mobility in central asia: costs and ...

    African Journals Online (AJOL)

    Retraction and expansion of flock mobility in central asia: costs and consequences. Carol Kerven, Ilya Ilych Alimaev, Roy Behnke, Grant Davidson, Leen Franchois, Nurlan Malmakov, Erik Mathijs, Aidos Smailov, Sayat Temirbekov, Iain Wright ...

  9. Focus Area Science Technology Summer Fellowship (FAST-SF)

    Indian Academy of Sciences (India)

    ... Chattoo Vijay Kumar Sharma Ahmed Hassan Zewail Sailendranath Roy Chaudhury Mangalore Vivekananda Bhatt Bahadur Chand Nakra Noshir Hormusji Wadia Charusita Chakravarty Paramasivam Natarajan Manoj Kumar Pal Chirayathumadom Venkatachalier Subramanian Deepak Kumar Subramania Ranganathan.

  10. Forthcoming Articles | Pramana – Journal of Physics | Journals ...

    Indian Academy of Sciences (India)

    ... Chattoo Vijay Kumar Sharma Ahmed Hassan Zewail Sailendranath Roy Chaudhury Mangalore Vivekananda Bhatt Bahadur Chand Nakra Noshir Hormusji Wadia Charusita Chakravarty Paramasivam Natarajan Manoj Kumar Pal Chirayathumadom Venkatachalier Subramanian Deepak Kumar Subramania Ranganathan.

  11. 10-Associateship | 3-Fellowship | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... Chattoo Vijay Kumar Sharma Ahmed Hassan Zewail Sailendranath Roy Chaudhury Mangalore Vivekananda Bhatt Bahadur Chand Nakra Noshir Hormusji Wadia Charusita Chakravarty Paramasivam Natarajan Manoj Kumar Pal Chirayathumadom Venkatachalier Subramanian Deepak Kumar Subramania Ranganathan.

  12. 94440 | php | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... Chattoo Vijay Kumar Sharma Ahmed Hassan Zewail Sailendranath Roy Chaudhury Mangalore Vivekananda Bhatt Bahadur Chand Nakra Noshir Hormusji Wadia Charusita Chakravarty Paramasivam Natarajan Manoj Kumar Pal Chirayathumadom Venkatachalier Subramanian Deepak Kumar Subramania Ranganathan.

  13. 98692 | php | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... Chattoo Vijay Kumar Sharma Ahmed Hassan Zewail Sailendranath Roy Chaudhury Mangalore Vivekananda Bhatt Bahadur Chand Nakra Noshir Hormusji Wadia Charusita Chakravarty Paramasivam Natarajan Manoj Kumar Pal Chirayathumadom Venkatachalier Subramanian Deepak Kumar Subramania Ranganathan.

  14. 93412 | php | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... Chattoo Vijay Kumar Sharma Ahmed Hassan Zewail Sailendranath Roy Chaudhury Mangalore Vivekananda Bhatt Bahadur Chand Nakra Noshir Hormusji Wadia Charusita Chakravarty Paramasivam Natarajan Manoj Kumar Pal Chirayathumadom Venkatachalier Subramanian Deepak Kumar Subramania Ranganathan.

  15. 99007 | php | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... Chattoo Vijay Kumar Sharma Ahmed Hassan Zewail Sailendranath Roy Chaudhury Mangalore Vivekananda Bhatt Bahadur Chand Nakra Noshir Hormusji Wadia Charusita Chakravarty Paramasivam Natarajan Manoj Kumar Pal Chirayathumadom Venkatachalier Subramanian Deepak Kumar Subramania Ranganathan.

  16. 99782 | php | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... Chattoo Vijay Kumar Sharma Ahmed Hassan Zewail Sailendranath Roy Chaudhury Mangalore Vivekananda Bhatt Bahadur Chand Nakra Noshir Hormusji Wadia Charusita Chakravarty Paramasivam Natarajan Manoj Kumar Pal Chirayathumadom Venkatachalier Subramanian Deepak Kumar Subramania Ranganathan.

  17. 94498 | php | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... Chattoo Vijay Kumar Sharma Ahmed Hassan Zewail Sailendranath Roy Chaudhury Mangalore Vivekananda Bhatt Bahadur Chand Nakra Noshir Hormusji Wadia Charusita Chakravarty Paramasivam Natarajan Manoj Kumar Pal Chirayathumadom Venkatachalier Subramanian Deepak Kumar Subramania Ranganathan.

  18. 99306 | php | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... Chattoo Vijay Kumar Sharma Ahmed Hassan Zewail Sailendranath Roy Chaudhury Mangalore Vivekananda Bhatt Bahadur Chand Nakra Noshir Hormusji Wadia Charusita Chakravarty Paramasivam Natarajan Manoj Kumar Pal Chirayathumadom Venkatachalier Subramanian Deepak Kumar Subramania Ranganathan.

  19. Effect of curing conditions and ionic additives on properties of fly ash ...

    Indian Academy of Sciences (India)

    Administrator

    Chemical Engineering Department, Durgapur Institute of Advanced Technology and Management,. Durgapur 713 ... Farry et al (1989) reported that the duration of the period ... Si–O bonds in the glassy, silica rich portions of fly ash. Roy and ...

  20. 77 FR 22361 - Entergy Nuclear Operations, Inc., (Indian Point Nuclear Generating Units 2 and 3); Notice of...

    Science.gov (United States)

    2012-04-13

    ... NRC E-Filing rule. See 10 CFR 2.302 et seq. Issued at Rockville, Maryland, this 9th day of April 2012. E. Roy Hawkens, Chief Administrative Judge, Atomic Safety and Licensing Board Panel. [FR Doc. 2012...

  1. 77 FR 71454 - Notice of Atomic Safety And Licensing Board Reconstitution, Tennessee Valley Authority (Watts Bar...

    Science.gov (United States)

    2012-11-30

    ... accordance with the NRC E-Filing rule. See 10 CFR 2.302 et seq. Issued at Rockville, Maryland this 16th day of November 2012. E. Roy Hawkens, Chief Administrative Judge, Atomic Safety and Licensing Board Panel...

  2. 75 FR 52996 - Areva Enrichment Services, LLC (Eagle Rock Enrichment Facility); Notice of Atomic Safety and...

    Science.gov (United States)

    2010-08-30

    ... correspondence, documents, and other materials shall continue to be filed in accordance with the NRC E-Filing rule. See 10 CFR 2.302 et seq. Issued at Rockville, Maryland, this 24th day of August 2010. E. Roy...

  3. 78 FR 56944 - Strata Energy, Inc. (Ross In Situ Recovery Uranium Project); Notice of Atomic Safety and...

    Science.gov (United States)

    2013-09-16

    ... correspondence, documents, and other materials shall continue to be filed in accordance with the NRC E-Filing rule. See 10 CFR 2.302 et seq. Issued at Rockville, Maryland this 10th day of September 2013. E. Roy...

  4. 77 FR 65417 - Northern States Power Company (Prairie Island Nuclear Generating Plant Independent Spent Fuel...

    Science.gov (United States)

    2012-10-26

    ..., documents, and other materials shall continue to be filed in accordance with the NRC E-Filing rule. See 10 CFR 2.302 et seq. Issued at Rockville, Maryland, October 22, 2012. E. Roy Hawkens, Chief...

  5. 76 FR 78702 - Progress Energy Florida, Inc. (Combined License Application for Levy County Nuclear Power Plant...

    Science.gov (United States)

    2011-12-19

    ... correspondence, documents, and other materials shall continue to be filed in accordance with the NRC E-Filing rule. See 10 CFR 2.302 et seq. Issued at Rockville, Maryland, this 13th day of December 2011. E. Roy...

  6. Muusika valib Tristan Priimägi / Tristan Priimägi

    Index Scriptorium Estoniae

    Priimägi, Tristan, 1976-

    2004-01-01

    Heliplaatidest: Roy Ayers "Virgin Ubiquity - Unreleased Recordings 1976-1981", "Ibadan People", "A Journey to the Dawn", The Matthew Herbert Big Band "Goodbye Swingtime", Amp Fiddler "Waltz of a Ghetto Fly"

  7. Indexes to Volume 56

    Indian Academy of Sciences (India)

    The gravitational wave symphony of the Universe. B S Sathyaprakash ... A verification of quantum field theory – measurement of Casimir force. Anushree Roy and U ... stability in the presence of parallel electric field. Harsha Jalori and A K ...

  8. Women Fellows of INAE | Women in Science | Initiatives | Indian ...

    Indian Academy of Sciences (India)

    Women Fellows of INAE. INAE - Indian National Academy of Engineering. Ms. Alpa Sheth Civil Engineering. Prof. Bharathi Bhat Electronics & Communication Engineering. Prof. Dipanwita Roy Chowdhury Computer Engineering and Information Technology. Prof. Kamala Krithivasan Computer Engineering and Information ...

  9. AUTHOR INDEX

    Indian Academy of Sciences (India)

    Administrator

    hol (MBBA)resin as polymer-supported synthesis support: ... 203. Luo S. Catalytic synthesis of 2-methylpyrazine over Cr-pro- .... Roy S C. Titanium(III) chloride mediated synthesis of furan ... Gas phase toluene isopropylation over high silica.

  10. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    locked loop-based auto-synchronising current-sourced converter for an induction heating prototype · MOLAY ROY MAINAK SENGUPTA · More Details Abstract Fulltext PDF. Induction heating (IH) converters operate just above resonant frequency, ...

  11. Tradition Unbroken? Social Dilemmas of Indian Tradition as Reflected in Two Indian Novels of the 1990's

    Czech Academy of Sciences Publication Activity Database

    Svobodová, Renata

    2003-01-01

    Roč. 71, č. 2 (2003), s. 129-154 ISSN 0044-8699 Institutional research plan: CEZ:AV0Z9021901 Keywords : Vikram Seth * Arundhati Roy * Indian Literature Subject RIV: AJ - Letters, Mass-media, Audiovision

  12. Some remarks on a scenario of supersymmetry in quantum mechanics

    International Nuclear Information System (INIS)

    Jannussis, A.; Tsohantzis, I; Vavougios, D.

    1990-01-01

    Some remarks are given on a recent paper of Lahiri, Kumar Roy and Bagchi who have constructed a scenario of supersymmetry in quantum mechanics by imposing a structure on the raising and lowering operators

  13. Pop / Mihkel Raud

    Index Scriptorium Estoniae

    Raud, Mihkel, 1969-

    2003-01-01

    Heliplaatidest: Hootie & the Blowfish "Hootie & the Blowfish", Bill Frisell "The Intercontinentals", Evan Dando "Baby I'm Bored", Terre Thaemlitz "Lovebomb", The Mighty Bop feat. Duncan Roy "The Mighty Bop"

  14. 75 FR 6026 - Environmental Impact Statements; Notice of Availability

    Science.gov (United States)

    2010-02-05

    ... of Mexico, Wait Period Ends: 03/08/2010, Contact: Roy E. Crabtree 727- 824-5701. EIS No. 20100027... and Fish Reintroduction Project, To Restore Connectivity, Biodiversity, and Natural Production of...

  15. Prevalence and causes of thrombocytopenia in an academic state ...

    African Journals Online (AJOL)

    medical emergencies, and appropriate laboratory investigation is indicated ... from the laboratory information system (DisaLab Version ..... Sekhon SS, Roy V. Thrombocytopenia in adults: A practical approach to evaluation and management.

  16. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 3 ... Great Experiments in Physics - Discovery of Transistor Effect that Changed the Communication World · Amit Roy · More Details Fulltext PDF. pp 14-25 General Article.

  17. 75 FR 57329 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2010-09-20

    ..., Tommy S. Boden, Travis D. Bjerk, Scott L. Colson, Dustin G. Cook, Nathan J. Enloe, Stephen J. Faxon, Joseph B. Hall, Mark H. Horne, Michael J. Hurst, Chad W. Lawyer, John R. Little, Roy L. McKinney, Thomas...

  18. Pop / Raul Ranne

    Index Scriptorium Estoniae

    Ranne, Raul

    2004-01-01

    Heliplaatidest: Genialistid "Genialistid", Roy Ayers "Mahogany Vibe", John Tejada "Logic Memory Center", Joss Stone "Mind, Body & Soul", Fatboy Slim "Palookaville", Soulwax "Any Minute Now", Erinevad esitajad "Super Discount 2"

  19. Courtship in Frogs

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 1; Issue 12. Courtship in Frogs Role of Acoustic Communication in Amphibian Courtship Behaviour. Debjani Roy. General Article Volume 1 Issue 12 December 1996 pp 39-48 ...

  20. USA juhtivpoliitik sai süüdistuse pettuses / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2005-01-01

    USA Kongressi vabariiklaste juht Tom DeLay astus ametist tagasi, kuna Texase osariigi Travise maakonna kohus esitas talle süüdistuse seotuse eest Texase valimiskampaania rahastamisskeemiga. Esindajatekoja uueks vabariiklaste juhiks sai Missouri osariigi kongresmen Roy Blunt

  1. Characteristics of pegmatoidal granite exposed near Bayalan, Ajmer ...

    Indian Academy of Sciences (India)

    near Bayalan, Ajmer district, Rajasthan. Nilanjan ... eastern flank of the South Delhi Fold Belt (Sinha. Roy 1984 .... gneisses in a lit-par-lit manner producing alternate layers of granite and ... shows a point concentration (table 1) with a mean.

  2. 77 FR 11620 - Notice of Request for the Extension of a Currently Approved Information Collection

    Science.gov (United States)

    2012-02-27

    ... Reduction Act of 1995, this notice announces the intention of the Federal Transit Administration (FTA) to... INFORMATION CONTACT: Roy Chen, FTA Office of Technology, (202) 366-0462, or email: royweishun.chen@dot.gov...

  3. USA kunstidessant Venemaale

    Index Scriptorium Estoniae

    2007-01-01

    USA kunstnike näitus "Kolm sajandit ameerika kunsti" Moskvas Pushkini muuseumis. Eksponeeritakse Mark Rothko, Jean-Michel Basguiat', Roy Lichtensteini, Robert Rauschenbergi, Georgia O'Keefe'i, Willem de Kooningi töid

  4. <300> GeV team

    CERN Multimedia

    CERN PhotoLab

    1971-01-01

    The 300 GeV team had been assembled. In the photograph are Hans Horisberger, Clemens Zettler, Roy Billinge, Norman Blackburne, John Adams, Hans-Otto Wuster, Lars Persson, Bas de Raad, Hans Goebel, Simon Van der Meer.

  5. 76 FR 20436 - Ninth Meeting: RTCA Special Committee 223: Airport Surface Wireless Communications

    Science.gov (United States)

    2011-04-12

    ... Phillips [ssbox] Co-Chair: Mr. Aloke Roy, Honeywell International [ssbox] Co-Chair: Mr. Ward Hall, ITT... Signal-in-space requirements Interface Requirements Interoperability requirements Tour of WiMAX testing...

  6. In memory of Paco Yndurain: A precise determination of ππ scattering from experiment and dispersion relations

    International Nuclear Information System (INIS)

    Pelaez, J.R.; Garcia Martin, R.; Kaminski, R.; Yndurain, F.J.

    2009-01-01

    This talk is dedicated to the memory of Paco Yndurain, the original speaker in the conference. After a short account of his scientific career, we briefly review our ongoing collaboration to determine precisely the ππ scattering amplitude including the most recent data by means of Forward Dispersion Relations and Roy Equations. A remarkable improvement in precision over the intermediate energy region is obtained by using once-subtracted Roy Equations in addition to the standard twice-subtracted ones

  7. Report on Contract W911NF-05-1-0339 (Clarkson University)

    Science.gov (United States)

    2012-11-30

    2012 59.00 Josiah Jebaraj J. Muthuraj, Don H. Rasmussen, Ian I. Suni. Electrodeposition of CuGaSe[sub 2] from Thiocyanate-Containing Electrolytes...Roy. Kinetic aspects of Li intercalation in mechano-chemically processed cathode materials for lithium ion batteries: Electrochemical characterization...Dipankar Roy. Electrochemical features of ball-milled lithium manganate spinel for rapid-charge cathodes of lithium ion batteries, Journal of Solid State

  8. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Articles written in Pramana – Journal of Physics. Volume 57 Issue 1 July 2001 pp 209-213 Contributed Papers : Nuclear reactions. Breakup of 42 MeVLi projectiles in the fields of 12C andAu nuclei · Dhruba Gupta C Samanta R Kanungo P Basu Subinit Roy S Kailas A Chatterjee B J Roy K Mahata A Samant A Shrivastava.

  9. Improving Deployment-Related Primary Care Provider Assessments of PTSD and Mental Health Conditions

    Science.gov (United States)

    2011-10-01

    Eich, P., Kiss , A., & Wossmer, B. (1998). Improving communication skills--a randomized controlled behaviorally oriented intervention study for...cases this misconduct was drug-related (Highfill-McRoy, Larson, Booth - Kewley, and Garland 2010).  Both experiencing trauma (i.e. being wounded...their data (Highfill-McRoy, Larson, Booth -Kewley, and Garland 2010). o In an article that reviewed 29 other studies on PTSD found that studies with the

  10. A Comparative Analysis of Army Physical Readiness Test Results of AMEDD Units Without Formal Physical Training Programs

    Science.gov (United States)

    1984-06-01

    Paul C.; Albrink , Margaret J.; and Krall, John M. "Exercise Effects on Fitness,, Lipids, Glucose Tolerance and Insulin Levels in Young Adults...1982): 14-15. Shepherd, Roy J.; Corey, Paul; Renzland, Peter; and Cox Michael . "The Impact of Changes in Fitness and Lifestyle Upon Health Care...Utilization." Canadian Journal of Public Health 74 (January/February 1983): 51-55. Shepherd, Roy J.; Corey, Paul; Renzland, Peter; and Cox, Michael . "The

  11. Fulltext PDF

    Indian Academy of Sciences (India)

    The relativistic wave equation of the electron ranks anlO- ng the highest achievements of 20th century science. Dirac's two papers on the subject published in 1928 are the following:- P.A.M. Dirac, Proc. Roy. Soc. Al17, 610, 1928. P.A.M. Dirac, Proc. Roy. Soc. Al18, 351, 1928. Dirac himself is supposed to have reuw.rked that ...

  12. Development of Novel Treatment Plan Verification Techniques for Prostate Intensity Modulation Arc Therapy

    Science.gov (United States)

    2010-03-01

    1090.U N C O R R E FLA 5.0 DTD ROB18972_proof 1E D P R O O F 11. Malinowski KT, Noel C, Roy M, et al. Efficient use of contin- uous, real-time...Physics Volume -, Number -, 2010 ARTICLE IN PRESS4. Malinowski KT, Noel C, Roy M, et al. Efficient use of contin- uous, real-time prostate localization

  13. Prostate biopsy

    Science.gov (United States)

    ... give the cells a grade called a Gleason score . This helps predict how fast the cancer will ... TRUS); Stereotactic transperineal prostate biopsy (STPB) Images Male reproductive anatomy References Babayan RK, Katz MH. Biopsy prophylaxis, ...

  14. Expression of Ku70 predicts results of radiotherapy in prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Tomokazu; Someya, Masanori; Hori, Masakazu; Nakata, Kensei; Kitagawa, Mio; Tsuchiya, Takaaki; Sakata, Koh-ichi [Sapporo Medical University School of medicine, Department of Radiology, Chuo-ku, Sapporo, Hokkaido (Japan); Matsumoto, Yoshihisa [Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, Meguro-ku, Tokyo (Japan); Nojima, Masanori [The University of Tokyo, The Institute of Medical Science Hospital, Minatoku, Tokyo (Japan); Masumori, Naoya [Sapporo Medical University School of medicine, Department of Urology, Chuo-ku, Sapporo, Hokkaido (Japan); Hasegawa, Tadashi [Sapporo Medical University School of medicine, Department of Surgical Pathology, Chuo-ku, Sapporo, Hokkaido (Japan)

    2017-01-15

    Therapeutic strategy for prostate cancer is decided according to T stage, Gleason score, and prostate-specific antigen (PSA) level. These clinical factors are not accurate enough to predict individual risk of local failure of prostate cancer after radiotherapy. Parameters involved with radiosensitivity are required to improve the predictive capability for local relapse. We analyzed 58 patients with localized adenocarcinoma of the prostate between August 2007 and October 2010 treated with 76 Gy of intensity-modulated radiotherapy (IMRT) as a discovery cohort and 42 patients between March 2001 and May 2007 treated with three-dimensional conformal radiotherapy (3D-CRT) as a validation cohort. Immunohistochemical examination for proteins involved in nonhomologous end-joining was performed using biopsy specimens. Ku70 expression was not correlated with various clinical parameters, such as the Gleason score and D'amico risk classification, indicating that Ku70 expression was an independent prognostic factor. The predictive value for PSA relapse was markedly improved after the combination of Gleason score and Ku70 expression, as compared with Gleason score alone. In patients treated with radiotherapy and androgen deprivation therapy (ADT), no relapses were observed in patients with Gleason score ≤7 or low Ku70 expression. In contrast, patients with Gleason score ≥8 and high Ku70 expression had high PSA relapse rates. In the validation cohort, similar results were obtained. Treatment with 76 Gy and ADT can be effective for patients with Gleason score ≤7 or low Ku70 expression, but is not enough for patients with Gleason score ≥8 and high Ku70 expression and, thus, require other treatment approaches. (orig.) [German] Die Behandlung beim Prostatakarzinom ist abhaengig von T-Stadium, Gleason-Score und prostataspezifischem Antigen (PSA). Diese klinischen Faktoren sind jedoch zu ungenau, um das individuelle Lokalrezidivrisiko beim Prostatakarzinom nach

  15. Duration of short-course androgen suppression therapy and the risk of death as a result of prostate cancer.

    LENUS (Irish Health Repository)

    D'Amico, Anthony V

    2011-12-10

    We evaluated whether the duration of androgen suppression therapy (AST) had an impact on the risk of prostate cancer-specific mortality (PCSM) in men with unfavorable-risk prostate cancer (PC) within established Gleason score (GS) categories.

  16. Hyposensitization therapy with whole pollen extract or purified allergens monitored by immunoblotting

    DEFF Research Database (Denmark)

    Jarolim, E; Matthiesen, F; Skov, P S

    1990-01-01

    . Inhibition experiments using allergenic components isolated by preparative sodium dodecyl sulphate-polyacrylamide gel electrophoresis indicated that all antigenic components of timothy grass pollen detected in immunoblot dispose of private and cross-reactive determinants for binding of human IgE. The worse......Patients allergic to grass pollen were hyposensitized with two major allergenic components or whole extract of timothy grass pollen. Specific IgE, IgG1, and IgG4 formed during immunotherapy were analyzed by immunoblotting. Similar antibody-binding patterns were observed in both patient groups...

  17. The Moses Mabhida Medical Plan: medical care planning and execution at a FIFA2010 stadium; the Durban experience

    OpenAIRE

    Timothy C Hardcastle; Mergan Naidoo; Sanjay Samlal; et al

    2010-01-01

    Timothy C Hardcastle1,2, Mergan Naidoo3,4, Sanjay Samlal5,6, Morgambery Naidoo5,6, Timothy Larsen5,6, Muzi Mabasu5,6,7, Sibongiseni Ngema6,81Inkosi Albert Luthuli Hospital, Mayville, South Africa; 2Department of Surgery, University of KwaZulu-Natal, Durban, South Africa; 3Wentworth Hospital, Durban, South Africa; 4Department of Family Medicine, University of KwaZulu-Natal, Durban, South Africa; 5Emergency Medical Rescue Service, KwaZulu-Natal, South Africa; 6Department of Health, KwaZulu-Nata...

  18. Fatty acid composition of forage herb species

    DEFF Research Database (Denmark)

    Warner, D.; Jensen, Søren Krogh; Cone, J.W.

    2010-01-01

    The use of alternative forage species in grasslands for intensive livestock production is receiving renewed attention. Data on fatty acid composition of herbs are scarce, so four herbs (Plantago lanceolata, Achillea millefolium, Cichorium intybus, Pastinaca sativa) and one grass species (timothy......, Phleum pratense) were sown in a cutting trial. The chemical composition and concentration of fatty acids (FA) of individual species were determined during the growing season. Concentrations of crude protein and FA were generally higher in the herbs than in timothy. C. intybus had the highest nutritive...

  19. NATO - Standardization of Equipment Now and in the Future.

    Science.gov (United States)

    1986-05-14

    RD-RI66 472 NATO - STANDRROIZRTION OF EGUI UET MOM AMO IN THE 1/1 FUTUREMU RY MAR COLL CARLISLE SARACKS PA T C SCOBIE 14 NAY SE UNCLASSIFIEP F/O 15/5...FUTURE BY COLONEL TIMOTHY C. SCOBIE D T IC IIELECTE JUN 17 LD DISTRIBUTION STATEMENT A: Approved for public release- distribution is unlimited. Aq14...AUTHOR(*) S. CONTRACT OR GRANT NUMBER(&) COL Timothy C. Scobie 9. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT. TASK AREA d WORK

  20. GOVERNMENTAL CONTROL ON JURNALISTIC PRACTICE IN 'PSEUDO-DEMOCRATIC' MALAYSIA AND SINGAPORE OR BIG COMPANY CONTROL ON JOURNALISTIC PRACTICE IN 'ESTABLISHED-DEMOCRATIC' AUSTRALIA: WHICH IS WORSE AND WHERE ARE THE PARALLESL

    Directory of Open Access Journals (Sweden)

    Elizabeth Sinclair

    2015-04-01

    Full Text Available Amanda Whiting and Timothy Marjoribanks argued in their chapter Media professional’s perceptions of defamation and other constraints upon news reporting in Malaysia and Singapore[1]that Malaysia and Singapore experience, due to a number of factors, restricted media freedom - many of these factors relating to the semi-democratic nature of Malaysian and Singaporean government. [1]Amanda Whiting and Timothy Marjoribanks, ‘Media Professionals' Perceptions of Defamation and other Constraints upon News Reporting in Malaysia and Singapore’ in Andrew Kenyon, Tim Marjoribanks, Amanda Whiting (eds. Democracy, Media and Law in Malaysia and Singapore (Routledge, London, 2013, 129-156.

  1. Obesity, body composition, and prostate cancer

    Directory of Open Access Journals (Sweden)

    Fowke Jay H

    2012-01-01

    Full Text Available Abstract Background Established risk factors for prostate cancer have not translated to effective prevention or adjuvant care strategies. Several epidemiologic studies suggest greater body adiposity may be a modifiable risk factor for high-grade (Gleason 7, Gleason 8-10 prostate cancer and prostate cancer mortality. However, BMI only approximates body adiposity, and may be confounded by centralized fat deposition or lean body mass in older men. Our objective was to use bioelectric impedance analysis (BIA to measure body composition and determine the association between prostate cancer and total body fat mass (FM fat-free mass (FFM, and percent body fat (%BF, and which body composition measure mediated the association between BMI or waist circumference (WC with prostate cancer. Methods The study used a multi-centered recruitment protocol targeting men scheduled for prostate biopsy. Men without prostate cancer at biopsy served as controls (n = 1057. Prostate cancer cases were classified as having Gleason 6 (n = 402, Gleason 7 (n = 272, or Gleason 8-10 (n = 135 cancer. BIA and body size measures were ascertained by trained staff prior to diagnosis, and clinical and comorbidity status were determined by chart review. Analyses utilized multivariable linear and logistic regression. Results Body size and composition measures were not significantly associated with low-grade (Gleason 6 prostate cancer. In contrast, BMI, WC, FM, and FFM were associated with an increased risk of Gleason 7 and Gleason 8-10 prostate cancer. Furthermore, BMI and WC were no longer associated with Gleason 8-10 (ORBMI = 1.039 (1.000, 1.081, ORWC = 1.016 (0.999, 1.033, continuous scales with control for total body FFM (ORBMI = 0.998 (0.946, 1.052, ORWC = 0.995 (0.974, 1.017. Furthermore, increasing FFM remained significantly associated with Gleason 7 (ORFFM = 1.030 (1.008, 1.052 and Gleason 8-10 (ORFFM = 1.044 (1.014, 1.074 after controlling for FM. Conclusions Our results

  2. Therapeutic Roles of Bmi-1 Inhibitors in Eliminating Prostate Tumor Stem Cells

    Science.gov (United States)

    2013-10-01

    ORGANIZATION NAME(S) AND ADDRESS(ES) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER New Jersey, University of Medicine and Dentistry ...classified according to postoperative Gleason score or clinical stage (TNM system ). Histological categories divided tumors with Gleason scores...On the basis of rapid adhesion on collagen, PCa cells were plated on a collagen-I dish for 5 min (5’=rapidly adherent) (3-5% of cells) were

  3. On cribriform prostate cancer

    OpenAIRE

    Kweldam, Charlotte

    2018-01-01

    markdownabstractThis general aim of the thesis is to study the clinical relevance, interobserver reproducibility, and genetics of cribriform growth in prostate cancer. More specifically, the aims and outline of this thesis are • To study the metastatic potential of modified Gleason score 3+3 prostate cancer in radical prostatectomies. (Chapter 2) • To examine the prognostic value of individual Gleason grade 4 patterns in prostate cancer in radical prostatectomy and diagnostic biopsy specimens...

  4. Polymorphism in molecular solids: an extraordinary system of red, orange, and yellow crystals.

    Science.gov (United States)

    Yu, Lian

    2010-09-21

    Diamond and graphite are polymorphs of each other: they have the same composition but different structures and properties. Many other substances exhibit polymorphism: inorganic and organic, natural and manmade. Polymorphs are encountered in studies of crystallization, phase transition, materials synthesis, and biomineralization and in the manufacture of specialty chemicals. Polymorphs can provide valuable insights into crystal packing and structure-property relationships. 5-Methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile, known as ROY for its red, orange, and yellow crystals, has seven polymorphs with solved structures, the largest number in the Cambridge Structural Database. First synthesized by medicinal chemists, ROY has attracted attention from solid-state chemists because it demonstrates the remarkable diversity possible in organic solids. Many structures of ROY polymorphs and their thermodynamic properties are known, making ROY an important model system for testing computational models. Though not the most polymorphic substance on record, ROY is extraordinary in that many of its polymorphs can crystallize simultaneously from the same liquid and are kinetically stable under the same conditions. Studies of ROY polymorphs have revealed a new crystallization mechanism that invalidates the common view that nucleation defines the polymorph of crystallization. A slow-nucleating polymorph can still dominate the product if it grows rapidly and nucleates on another polymorph. Studies of ROY have also helped understand a new, surprisingly fast mode of crystal growth in organic liquids cooled to the glass transition temperature. This growth mode exists only for those polymorphs that have more isotropic, and perhaps more liquid-like, packing. The rich polymorphism of ROY results from a combination of favorable thermodynamics and kinetics. Not only must there be many polymorphs of comparable energies or free energies, many polymorphs must be kinetically stable and

  5. The treatment of prostate cancer by conventional radiation therapy: an analysis of long-term outcome

    Energy Technology Data Exchange (ETDEWEB)

    Zietman, Anthony L; Coen, John J; Dallow, Katherine C; Shipley, William U

    1995-05-15

    Purpose: To assess the long-term outcome of conventional external beam radiation therapy in the management of clinically confined prostate cancer and to examine the proposition that radiation accelerates tumor growth in those who fail treatment. Methods and Materials: One thousand and forty-four men with T1-4NxM0 prostate cancer treated by conventional external beam radiation therapy at the Massachusetts General Hospital between 1977 and 1991 were analyzed. Median follow-up was 49 months. Failure was defined as: two sequential rises in serum prostate specific antigen (PSA) level; or a PSA > 1 ng/ml 2 or more years after radiation; or any clinical failure. Kaplan-Meier actuarial analyses were used to assess outcome. Results: At 10 years only 40% of the T1-2 group remained disease free. When subdivided by grade, the well-differentiated tumors (Gleason 1-2) exhibited a 53% actuarial 10-year disease-free survival, moderately differentiated (Gleason 3) 42%, and poorly differentiated (Gleason 4-5) 20%. The corresponding values for the T3-4 men were 33% for Gleason 1-2, 20% for Gleason 3, and 10% for Gleason 4-5. Overall the value for T3-4 tumors was 18% at 10 years. On relapse the median PSA doubling times for the T1-2 patients were predicted by histology: 18.8 months for Gleason 1-2 patients; 11.1 months for Gleason 3; and 9.6 months for Gleason 5. Significant differences were found between the Gleason 3 and the Gleason 4-5 groups (p = 0.04) and the Gleason 1-2 and the Gleason 4-5 groups (p = 0.03). A wide range of doubling times was seen within each grade group. When compared with recently reported data on selected T1-2 patients who were managed by expectant observation there was no advantage over the first decade (and certainly no disadvantage) in terms of metastasis-free survival or disease-specific survival for the irradiated Gleason 1-3 patients. However, a gain was seen for those with Gleason 4-5 tumors. Conclusion: Less than half of the T1-2NxM0 and less than one

  6. Ikke en tid til mesterværker

    DEFF Research Database (Denmark)

    Thomsen, Torsten Bøgh

    2014-01-01

    Artiklen præsenterer en diskussion af den seneste miljøorienterede kulturteori indenfor retningen Spekulativ Realisme (Graham Harman, Timothy Morton) og sætter den i en historisk kontekst gennem romantisk filosofi og antikkens begreb om genius loci. Ydermere knyttes disse begreber specifikt til...

  7. Malaria Genome Sequencing Project

    Science.gov (United States)

    2004-01-01

    UTTERBACK, TERESA RIGGS, FLORENCE VAN AKEN, SUSAN RIZZO, MICHAEL VISWANATHAN, LAKSHMI ROMERO , CALUDIA DEVI ROONEY, TIMOTHY VON ARX, ANNA RUCH, KAREN...Clark*, R. Clark*, C. Corton *, well with the predictions from the optical map. Chromosome 13 is A. Cronin*, R. Davies*, P. Davis*, P. Dear§, F. Dearden

  8. Využití metod koučování v práci školního psychologa a školním prostředí

    OpenAIRE

    Libert, Tomáš

    2010-01-01

    The thesis is dealing with potential of improvement of coaching metohods in school psychologist practises and school environment. Theoretical part of the thesis is focused on coaching trends and maping diferent accesses to coaching. The practical part is dealing with specific method of coaching, the Inner Game, which was created by Timothy Gallwey and its utilization in in two cases in school psychologist practise.

  9. Coalition Warfare Program Tactile Situation Awareness System for Aviation Applications: Simulator Flight Test

    Science.gov (United States)

    2015-12-01

    David Myers1 Timothy Gowen2 Angus Rupert3 Ben Lawson3 Justin Dailey3,4 1Chesapeake Technology International 2Naval Aviation Center for... Angus Rupert of the USAARL. The algorithm is described in “Configuration Parameters for the Tactile Situation Awareness System (TSAS)” dated July 2010

  10. 77 FR 68769 - Access to Confidential Business Information by Abt Associates, Inc.

    Science.gov (United States)

    2012-11-16

    ... industrial chemicals. Since other entities may also be interested, the Agency has not attempted to describe... information which has been submitted to EPA under section 8 of the Toxic Substances Control Act (TSCA). Some...: For technical information contact: Timothy Kiely, Office of Chemical Safety & Pollution Prevention...

  11. Identification and Targeting of Tyrosine Kinase Activity in Prostate Cancer Initiation, Progression, and Metastasis

    Science.gov (United States)

    2013-12-01

    University) "Effectors of the DNA damage and radiotherapy response in cancer" 9:20 pm - 9:30 pm Discussion TUESDAY 7:30 am - 8:30 am Breakfast 9:00...M. Morris , Hideki Onagi, Timothy M. Altamore, Allan B. Gamble, Christopher J. Easton Prohormone-substrate peptide sequence recognition by

  12. CDApps: integrated software for experimental planning and data processing at beamline B23, Diamond Light Source. Corrigendum.

    Science.gov (United States)

    Hussain, Rohanah; Benning, Kristian; Myatt, Daniel; Javorfi, Tamas; Longo, Edoardo; Rudd, Timothy R; Pulford, Bill; Siligardi, Giuliano

    2015-05-01

    In the paper by Hussain et al. [(2015), J. Synchrotron Rad. 22, 465-468], Daniel Myatt is missing from the list of authors. The complete list of authors should be Rohanah Hussain, Kristian Benning, Daniel Myatt, Tamas Javorfi, Edoardo Longo, Timothy R. Rudd, Bill Pulford and Giuliano Siligardi.

  13. Southern African Journal of Anaesthesia and Analgesia - Vol 23, No ...

    African Journals Online (AJOL)

    Robert Wise, Kim de Vasconcellos, David Skinner, Reitze Rodseth, Dean Gopalan, David Muckart, Zohra Banoo, Tashmin Bisseru, Steve Blakemore, Jenine de Meyer, Michael Faurie, Kom Govender, Timothy Hardcastle, Prakash Jeena, Nicky Kalafatis, Kroshlan Kistan, Theroshnie Kisten, Carolyn Lee, Colin Mitchell, ...

  14. 78 FR 1265 - Sunshine Act; Notice of Meeting

    Science.gov (United States)

    2013-01-08

    ... South (both entry and exit). For those attending the La Jolla meeting, parking is expected to be..., 4340 East-West Highway, Room 700, Bethesda, Maryland 20814. The Commission already has met with...: Timothy J. Ragen, Executive Director, Marine Mammal Commission, 4340 East-West Highway, Room 700, Bethesda...

  15. 76 FR 71437 - Mutual Savings Association Advisory Committee

    Science.gov (United States)

    2011-11-17

    ... (MSAAC or Committee) formerly administered by the Office of Thrift Supervision, as it is necessary and in...: Timothy T. Ward, Deputy Comptroller for Thrift Supervision, 250 E Street SW., Washington, DC 20219. FOR... as federal savings associations (including federal savings banks); and (2) issue charters therefore...

  16. The Effect Of Supraphysiologic Blood Pressure on Traumatic Brain Injury and Proximal Tissue Beds During Resuscitative Balloon Occlusion of the Aorta and Variable Aortic Control in a Porcine Model (Sus scrofa) of Polytrauma.

    Science.gov (United States)

    2017-04-27

    Control In A Porcine Model (Sus Scrofa) Of Polytrauma . PRINCIPAL INVESTIGATOR (PI) / TRAINING COORDINATOR (TC): Lt Col Timothy Williams DEPARTMENT...Mandatory) The Effect of REBOA, Partial Aortic Occlusion and Aggressive Blood Transfusion on Traumatic Brain Injury in a Swine Polytrauma Model

  17. The Effect of Interface Treatment on Ceramic Performance and Modeling Dyneema Subjected to Ballistic Impact

    Science.gov (United States)

    2018-01-23

    Mechanical Engineering Division January 26, 2018 Professor KT Ramesh JHU/HEMI Project Director Johns Hopkins University 3400 N. Charles...Sincerely, Timothy J. Holmquist Institute Engineer ...Director Record Copy B (Contracts) Engineering Dynamics Department The Effect of Interface Treatment on Ceramic Performance and

  18. Ostrich: Journal of African Ornithology - Vol 75, No 4 (2004)

    African Journals Online (AJOL)

    Fowl play: identification and management of hybridisation between wild and domestic Helmeted Guineafowl (Numida meleagris) in South Africa · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Andrew L Walker, Rauri CK Bowie, Charles S Ratcliffe, Timothy M Crowe, 195-198.

  19. Cliché, Gossip, and Anecdote as Supervision Training

    Science.gov (United States)

    Grealy, Liam

    2016-01-01

    This article expands on a co-authored project with Timothy Laurie on the practices and ethics of higher degree research (HDR) supervision (or advising): "What does good HDR supervision look like?" in contemporary universities. It connects that project with scholarship on the relevance of "common sense" to questions of…

  20. Equine pre-caecal and total tract digestibility of individual carbohydrate fractions and their effect on caecal pH response

    DEFF Research Database (Denmark)

    Brøkner, Christine; Austbø, Dag; Næsset, Jon Anders

    2012-01-01

    with a sequence of 17 days adaptation to the ration followed by 8 sampling days. The feed rations consisted of only timothy hay (Group H), hay plus molassed sugar beet pulp combined with either whole oats (Group OB) or barley (Group BB) and hay plus loose chaff based concentrate (Group M). Four horses fitted...

  1. Metabolic response to dietary fibre composition in horses

    DEFF Research Database (Denmark)

    Brøkner, Christine; Austbø, D.; Næsset, J. A.

    2016-01-01

    . The feed rations consisted of only timothy hay (H), hay plus molassed sugar beet pulp combined with either whole oats (OB) or barley (BB) and hay plus a loose chaff-based concentrate (M). Four horses were fitted with permanent caecal cannulas and liquid caecal content was withdrawn manually and blood...

  2. Attracting, Developing, and Maintaining Human Capital: A New Model for Economic Development

    Science.gov (United States)

    America's Promise Alliance (NJ1), 2011

    2011-01-01

    "Investing in Kids: Early Childhood Programs and Local Economic Development," a 2011 book by Timothy Bartik, Senior Economist at the W.E. Upjohn Institute for Employment Research, provides a new evidence-based approach for effective economic development. This approach is designed to support business growth and job creation by improving…

  3. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Ardashir K Masouleh. Articles written in Journal of Biosciences. Volume 37 Issue 5 November 2012 pp 829-841 Articles. Application of large-scale sequencing to marker discovery in plants · Robert J Henry Mark Edwards Daniel L E Waters S Gopala Krishnan Peter Bundock Timothy ...

  4. Protein Laboratories in Single Location | Poster

    Science.gov (United States)

    By Andrew Stephen, Timothy Veenstra, and Gordon Whiteley, Guest Writers, and Ken Michaels, Staff Writer The Laboratory of Proteomics and Analytical Technologies (LPAT), Antibody Characterization Laboratory (ACL), and Protein Chemistry Laboratory (PCL), previously located on different floors or in different buildings, are now together on the first floor of C wing in the ATRF.

  5. Installation Guidance for Centerline and Edgeline Rumble Strips in Narrow Pavements

    Science.gov (United States)

    2017-09-01

    Peter T. Savolainen (orcid.org/0000-0001-5767-9104); Anuj Sharma (orcid.org/0000-0001-5929-5120); Timothy P. Barrette (orcid.org/0000-0002- 7656-3454); Bijan Vafaei (orcid.org/0000-0002-9362-399X); and Trevor J. Kirsch (orcid.org/0000-0002-8163-1570)...

  6. User’s Supplement to MIL-STD-740-2 Modified for Measurements to 20 KHz

    Science.gov (United States)

    1989-10-01

    Process Compressor Div. 100 Chemung Street 1 AMI Research Painted Post, NY 14870 2 Captain Walk 1 James Seibert New London, CT 06320 1 Mark Clifton 1...CT 06340-4909 942 Memorial Pkwy. 1 Wilf Kalbach Phillipsburg, NJ 08865 1 David Mewha 1 Timothy Luce 1 Ed Miller 1 Kevin Brimmer 2 ITW Linac 1 Robert

  7. Tapping the Power of Poetry

    Science.gov (United States)

    Rasinski, Timothy

    2014-01-01

    "I have become increasingly convinced that poetry offers one of the best-and often most underused--resources for developing literacy foundations," writes Timothy Rasinski. Poetry and songs are typically short and easy to learn, provide opportunities for students to play with the sounds of language, and offer an engaging way to learn…

  8. New Equipping Strategies for Combat Support Hospitals

    Science.gov (United States)

    2010-01-01

    Combat and Doctrine Development and COL Timothy Lamb , supported by MAJ Gary Cooper, included members of our team in visits to Sierra Army Depot and...aspect of improving materiel stew - ardship is improving the quality of data related to the procurement, maintenance, and upgrading of equipment

  9. Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment | Poster

    Science.gov (United States)

    Noriho Iida, Amiran Dzutsev, C. Andrew Stewart, Loretta Smith, Nicolas Bouladoux, Rebecca A. Weingarten, Daniel A. Molina, Rosalba Salcedo, Timothy Back, Sarah Cramer, Ren-Ming Dai, Hiu Kiu, Marco Cardone, Shruti Naik, Anil K. Patri, Ena Wang, Francesco M. Marincola, Karen M. Frank, Yasmine Belkaid, Giorgio Trinchieri, Romina S. Goldszmid Science 342(6161):967-970, 2013

  10. 75 FR 49551 - Petition for Waiver of Compliance

    Science.gov (United States)

    2010-08-13

    ... below. Docket Number FRA-1998-4821 Applicant: Mr. Timothy R. Luhm, Canadian National, Manager S&C, 17641 South Ashland Avenue, Homewood, Illinois 60430. The Canadian National (CN) seeks an extension for an... expire on April 25, 2011. In addition to the extension, CN requests that the allowable maximum authorized...

  11. Scopus: Journal of East African Ornithology - Vol 36, No 2 (2016)

    African Journals Online (AJOL)

    Avifauna of Boni-Dodori National Reserves, Lamu and Garissa Counties, Kenya · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Tobias Otieno, Timothy Mwinami, Martha Ngala, Sandy Oduor, Fleur Ng'weno, Simon Musila, Charles Kimwele, 1-16 ...

  12. R-ES-ONANCE--INo-ve-mber

    Indian Academy of Sciences (India)

    Physiology or Medicine: has been jointly awarded to. Leland H Hartwell, Fred Hutchinson Cancer Research Center, University of Seattle, USA. R Timothy (Tim) Hunt, Clare Hall Laboratories, Cell Cycle Control Laboratory, UK. Paul M Nurse, Lincoln's Inn Fields Laboratories, Cell Cycle Laboratory, UK for their discoveries of ...

  13. Marine Science

    African Journals Online (AJOL)

    Copy Editor Timothy Andrew. Published ... 2007; Zhou et al., 2009) and they play an important role in the ... At both sites, zonal variation in TMPB was evident with significantly higher C-biomass closer to ... ton is considered to be an essential parameter in eco- systems ...... logical significance of toxic marine dinoflagellates.

  14. Induced pluripotent stem cell-derived neuron as a human model for testing environmentally induced developmental neurotoxicity

    Science.gov (United States)

    Induced pluripotent stem cell-derived neurons as a human model for testing environmentally induced developmental neurotoxicity Ingrid L. Druwe1, Timothy J. Shafer2, Kathleen Wallace2, Pablo Valdivia3 ,and William R. Mundy2. 1University of North Carolina, Curriculum in Toxicology...

  15. Festival "Maailmafilm" sobib hästi akadeemilise vaimuga linna / Kadri Rannamäe

    Index Scriptorium Estoniae

    Rannamäe, Kadri

    2008-01-01

    V festivali "Maailmafilm", mis algab 24. märtsil Eesti Rahva Muuseumi näitusemajas Tartus, tutvustavad muuseumi direktor Kristjan Raba ja festivali tegevjuht Taavi Tatsi. Esilinastub Liivo Niglase, Diane Perlovi ja Frode Storaasi "Kalarahvas". Kavas on ka eriprogrammid: kirjanikud filmis, klassiku Timothy Aschi filmid Amazonase indiaanlastest ja filmid inimesest linnas

  16. 75 FR 70224 - New York Tidal Energy Company; Notice Concluding Pre-Filing Process and Approving Process Plan...

    Science.gov (United States)

    2010-11-17

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 12665-003] New York Tidal... Tidal Energy Company. e. Name of Project: East River Tidal Energy Pilot Project. f. Location: In the...-6405. i. FERC Contact: Timothy Konnert (202) 502-6359. j. New York Tidal Energy Company (NYTEC) has...

  17. Resilient Communication: A New Crisis Communication Strategy for Homeland Security

    Science.gov (United States)

    2012-03-01

    communication theory. Author, Timothy Coombs , in Ongoing Crisis Communication , discusses the need for a crisis management 10 plan to prepare for potential... COMMUNICATION : A NEW CRISIS COMMUNICATION STRATEGY FOR HOMELAND SECURITY by Sharon L. Watson March 2012 Thesis Advisor: Christopher Bellavita...REPORT TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE Resilient Communication : A New Crisis Communication

  18. Becoming More Than a Digital Bullhorn: Two Way Engagement on Twitter for Law Enforcement

    Science.gov (United States)

    2016-03-01

    filebank/documents/43341. 174 Coombs , W. Timothy, and Sherry Jean Holladay. “How Publics React to Crisis Communication Efforts: Comparing Crisis ...way communication , crisis communications , followers, open government, transparency, responsiveness, public affairs, public information officer (PIO...for crisis communications is becoming increasingly widespread; the more followers an agency social media account has, the more people they can

  19. Evaluation of the WavTrac Expeditionary Mobility Matting System

    Science.gov (United States)

    2017-04-01

    Dr. Timothy W. Rushing was Chief, APB; Dr. Gordon W. McMahon was Chief, ESMD; and Nicholas Boone was the Technical Director for Force Projection...were tan in color and had a nonskid material applied to the wearing surface. Typical mat dimensions were 12 ft, 2 in. wide by 48 ft, 6 in. long

  20. Muslim Prison Ministry: Hindering the Spread of the Radical, Militant, Violent and Irreconcilable Wing of Islam

    Science.gov (United States)

    2006-05-25

    radical, militant, violent and irreconcilable wing of Islam Approved by: __________________________________ Monograph Director Timothy L . Challans, Ph.D...Honorable Harley Lapin (BOP), Dr. Michael Waller (Institute of World Politics), Mr. Paul Rogers (ACCA), and Mr. A. J. Sabree (ACCA). 78 Ibid., 12...London, United Kingdom: Verso books, 2005. Patai, Raphael. The Arab Mind, Long Island City, NY: Hatherleigh Press, 2002. Pederson , Dick. Defeating

  1. Knowledge-Driven Design of Virtual Patient Simulations

    Science.gov (United States)

    Vergara, Victor; Caudell, Thomas; Goldsmith, Timothy; Panaiotis; Alverson, Dale

    2009-01-01

    Virtual worlds provide unique opportunities for instructors to promote, study, and evaluate student learning and comprehension. In this article, Victor Vergara, Thomas Caudell, Timothy Goldsmith, Panaiotis, and Dale Alverson explore the advantages of using virtual reality environments to create simulations for medical students. Virtual simulations…

  2. Kodanike või riikide Euroopa? / Julia Laffranque

    Index Scriptorium Estoniae

    Laffranque, Julia, 1974-

    2005-01-01

    Demokraatiast, Euroopa põhiseaduse lepingust ja Euroopa Liidu tulevikust. Lisatud: samal teemal: Briti ajaloolane Timothy Garton Ash: mure immigrantide pärast tõi kriisi ; Prantsuse filosoof Paul Virillo: rahvahääletus ise oli suurim viga

  3. Brief psychotic disorder

    Science.gov (United States)

    ... as the cause of the symptoms. Treatment By definition, psychotic symptoms go away on their own in ... severely disrupt your life and possibly lead to violence and suicide. ... by: Timothy Rogge, MD, Medical Director, Family Medical Psychiatry Center, Kirkland, WA. Also reviewed by ...

  4. Xpand chest drain: assessing equivalence to current standard ...

    African Journals Online (AJOL)

    leakage from 'open to air' system or breakage of glass bottle (with associated risk to ... and an air-leak detection system. It is connected to a ... need to add water. Xpand chest drain: assessing equivalence to current standard therapy – a randomised controlled trial. CHARL COOPER, M.B. CH.B. TIMOTHY HARDCASTLE ...

  5. 77 FR 50508 - Change in Bank Control Notices; Formations of, Acquisitions by, and Mergers of Bank Holding...

    Science.gov (United States)

    2012-08-21

    ..., Cando, North Dakota; Timothy Dodd and Bradley Fey, both of Bismarck, North Dakota; Jeffrey Topp, Grace City, North Dakota; Janet Topp, Grace City, North Dakota; and Roger Kenner, Leeds, North Dakota; as a... (Jacqueline G. King, Community Affairs Officer) 90 Hennepin Avenue, Minneapolis, Minnesota 55480-0291: 1. MVC...

  6. New Attitudes Shaping Labor-District Relations

    Science.gov (United States)

    Sawchuk, Stephen

    2012-01-01

    Back in the mid-2000s, in public and in the news media, Joseph P. Burke, then superintendent of the Springfield public schools, and Timothy T. Collins, president of the local teachers' union, often seemed to be at odds with each other. Out of the public eye, however, the two men had begun meeting regularly. When Burke left the district, the work…

  7. The Era of HIV Cure Research | Michael | Annals of Ibadan ...

    African Journals Online (AJOL)

    Timothy Ray Brown is widely referred to as the first HIV patient to be cured of the disease. He received a CCR5 deficient bone marrow transplant as a treatment for Acute Myeloid Leukemia, with HAART controlled HIV-1 infection at the background. Seven years after the transplant, and discontinuation of HAART, he has been ...

  8. Turu festivali võitjad kujutavad Eestit imelise muinasjutumaana / Eva Toome

    Index Scriptorium Estoniae

    Toome, Eva

    2001-01-01

    I Turu animafestivali Tough Eye grand prix läks jagamisele. Selle said Igor Kovaljovi joonisfilm "Tema naine kana" : Nõukogude Liit 1990 ja kaksikvendade Stephen ja Timothy Quay "In Absentia" : Suurbritannia 2000. Auhinnasaajad vastavad paarile küsimusele festivali ja Eesti kohta

  9. Author Details

    African Journals Online (AJOL)

    Timothy, EE. Vol 10, No 2 (2011) - Articles Students' perception of teacher's knowledge of subject matter and reading comprehension performance of SS 3 students in Cross River State, Nigeria Abstract PDF. ISSN: 1596-6224. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

  10. African Journal of AIDS Research - Vol 13, No 2 (2014)

    African Journals Online (AJOL)

    Love, lust and the emotional context of multiple and concurrent sexual partnerships among young Swazi adults · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Allison Ruark, Lunga Dlamini, Nonhlanhla Mazibuko, Edward C Green, Caitlin Kennedy, Amy Nunn, Timothy Flanigan, ...

  11. Ada Dual-Use Summary: Ada Dual-Use Workshop Held in Vienna, Virginia on October 19-20, 1993. Ada Dual-Use Committee Briefing, November 8, 1993

    Science.gov (United States)

    1993-11-29

    Systems Agency C- 19 Novemtiber 8., 1993 Promoting the Use of Ada in Computer Science Curricula Timothy J. Long Ohio State University ®I To L4 ease...framework, distributed file systems, a high-performance fiber-optic connection and multi-processor modules to work with the OSF’s Mach 3 microkernel (again

  12. National Wetland Plant List Indicator Rating Definitions

    Science.gov (United States)

    2012-07-01

    glaucus (blue rye grass), Eragrostis pilosa (Indian love grass), Oenothera biennis (king’s-cureall), Ostrya virginiana (eastern hop-hornbeam...profile with a low wa- ter-holding capacity. ERDC/CRREL TN-12-1 6 Prunus serotina (black cherry), Phleum pretense (common timothy), Sarcobatus

  13. Counter Piracy: A Repeated Game with Asymmetric Information

    Science.gov (United States)

    2009-09-01

    Christopher D. Marsh Approved by: Kyle Y. Lin Thesis Advisor Timothy H. Chung Second Reader Robert F. Dell Chairman, Department of...encourage Malaysia and Indonesia to work with the Singapore Navy in coordinated patrols of the region. Increased cooperation in the region includes the

  14. A Modular Simulation Framework for Assessing Swarm Search Models

    Science.gov (United States)

    2014-09-01

    SCHOOL September 2014 Author: Blake M. Wanier Approved by: Timothy H. Chung Thesis Advisor James Eagle Second Reader Robert Dell Chair, Department of...shipments of natural gas from Indonesia and Malaysia are redirected to China to support its growing domestic consumption, Japan’s discovery of large

  15. 75 FR 9248 - Endangered and Threatened Wildlife and Plants; Permit Applications

    Science.gov (United States)

    2010-03-01

    ... Applications Permit Application Number: TE006012. Applicant: Steven Taylor, Center for Biodiversity, Illinois... State University, Springfield, Missouri. The applicant requests a permit renewal to take (capture and... Application Number: TE02560A. Applicant: Timothy C. Carter, Ball State University, Muncie, Indiana. The...

  16. Return to Resistance

    International Development Research Centre (IDRC) Digital Library (Canada)

    Book design by Timothy Rice .... Crop production has increased also, very considerably, but so have the crop losses due to parasites, in spite ...... The pesticide manufacturers often refer to their take-overs of plant breeding and seed production ...

  17. Browse Title Index

    African Journals Online (AJOL)

    Items 501 - 550 of 823 ... Dario Kuron Lado. Vol 14, No 1 (2009), Patterns of spinal injury in a new neurosurgical centre: A 2-year prospective study, Abstract PDF. JKC Emejulu, OC Ekweogwu, Timothy Nottidge. Vol 18, No 2 (2013), Patterns of Traumatic Intracranial Bleeds at Kenyatta National Hospital in Nairobi, Kenya ...

  18. 77 FR 1019 - Renewable Energy Alternate Uses of Existing Facilities on the Outer Continental Shelf-Acquire a...

    Science.gov (United States)

    2012-01-09

    ...-0045] RIN 1010-AD79 Renewable Energy Alternate Uses of Existing Facilities on the Outer Continental... rule related to acquiring a lease non-competitively for offshore renewable energy projects. DATES... or Timothy Redding, Renewable Energy, BOEM, at (703) 787-1219 or email [email protected

  19. Mida mõtlevad tippjuhid? / interv. John A. Byrne

    Index Scriptorium Estoniae

    2008-01-01

    USA majandusliku olukorra ja tulevikuprognooside üle arutlevad FedExi juht Fred Smith, Chrysleri tegevjuht Robert Nardell, endine General Electric'u aseesimees Dennis Dammerman, Caritas Christi Health Care tegevjuht Ralph de la Torre, Abbott Labs tegevjuht Miles White, FPL Group tegevjuht Lewis Hay, BorgWarneri tegevjuht Timothy Manganello ning Schering-Plough tegevjuht Fred Hassan

  20. ACTH (Adrenocorticotropic Hormone) Test

    Science.gov (United States)

    ... Reviews Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition]. Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory ... Medical Encyclopedia [On-line information]. Available online at http:// ...

  1. Real-Time Target Motion Animation for Missile Warning System Testing

    Science.gov (United States)

    2006-04-01

    T. Perkins, R. Sundberg, J. Cordell, Z. Tun , and M. Owen, Real-time Target Motion Animation for Missile Warning System Testing, Proc. SPIE Vol 6208...Z39-18 Real-time target motion animation for missile warning system testing Timothy Perkins*a, Robert Sundberga, John Cordellb, Zaw Tunb, Mark

  2. 75 FR 60750 - Granting of Request for Early Termination of the Waiting Period Under the Premerger Notification...

    Science.gov (United States)

    2010-10-01

    ...-AUG-10 20100676 G UAL Corporation. G Continental Airlines, Inc. G Continental Airlines, Inc. 20100959 G OCM Principal Opportunities Fund IV, L.P. G Advance Food Company Holdings, Inc. G Advance Food Company, Inc. 20101002 G Alfa S.A.B. de C.V. G Timothy T. Day. G Bar-S Foods Co. 20101019 G Pinafore...

  3. 77 FR 64967 - Senior Executive Service; Performance Review Board

    Science.gov (United States)

    2012-10-24

    ... BROWN, STEPHANIE H BRYAN, WILLIAM N BURROWS, CHARLES W BUTTRESS, LARRY D CADIEUX, GENA E CALBOS, PHILIP..., CAROL J BEAMON, JOSEPH A BEARD, JEANNE M BEARD, SUSAN F BEAUSOLEIL, GEOFFREY L BEKKEDAHL, LARRY N BELL..., HENRY C KELLY, JOHN E KELLY, LARRY C KENCHINGTON, HENRY S KENDELL, JAMES M KETCHAM, TIMOTHY E KHAN...

  4. Browse Title Index

    African Journals Online (AJOL)

    Items 1 - 26 of 26 ... Vol 2 (2003), Towards a Richer Intercultural Philosophy for Africa, Abstract. Timothy D Kanakulya. Vol 6, No 1 (2007), Translating policy in the teaching of history: curriculumas a product of an activity system, Abstract. R Nsibande, M Modiba. Vol 2 (2003), Trinidadian Calypso and Mississippi Delta Blues in ...

  5. 78 FR 68019 - Performance Review Board Appointments

    Science.gov (United States)

    2013-11-13

    ..., Arlean; Leonard, Joe; Linden, Ralph A.; Lippold, David; Lowe, Christopher S.; Lowe, Stephen O.; Maddux..., Michael; Nelson, Leiann H.; Willis, Brandon C.; Witt, Timothy; Worth, Thomas W. Food, Nutrition and...; Primrose, Edna; Ross, Robert H.; Salguero, Francisco. Rural Utilities Service Ackerman, Kenneth; Adams...

  6. PV Module Reliability Workshop | Photovoltaic Research | NREL

    Science.gov (United States)

    Gok, Cara Fagerholm, David M. Burns, Timothy J. Peshek, Laura S. Bruckman, Roger H. French Backsheet Chen, C. H. Hsueh, W. J. Hsieh Accurately Measuring PV Power Loss Due to Soiling-Michael Gostein and Walters, Stephen Barkaszi Tracking PV Changes: Bridging Between Thin-Film Cells and Modules-Russell

  7. Teaching Hospital and Other Issues Related to Graduate Medical Education. Hearing before the Subcommittee on Health of the Committee on Ways and Means. House of Representatives, One Hundred Fourth Congress, Second Session (June 11, 1196).

    Science.gov (United States)

    Congress of the U.S., Washington, DC. House Committee on Ways and Means.

    This document reports testimony presented on Medicare financing of graduate medical education, as proposed by the Balanced Budget Act of 1995. Witnesses included: (1) Timothy M. Golddfarb, Director, Healthcare Systems (Oregon), who noted the importance of graduate medical education funding to teaching hospitals; (2) Leo P. Brideau of Strong…

  8. Obama kriisitiimi juhib tugev kolmik / Sirje Rank

    Index Scriptorium Estoniae

    Rank, Sirje, 1966-

    2008-01-01

    USA presidendiks valitud Barack Obama kuulutab ametlikult välja oma meeskonna liikmed. Tulevane rahandusminister Timothy Geithner ning Valge Maja koordinatsiooni nõukogu tulevane juht Lawrence Summers seisavad vastamisi finantskriisi ületamise ning finantssüsteemi stabiliseerimise ülesandega

  9. Marine Science

    African Journals Online (AJOL)

    Chief Editor José Paula | Faculty of Sciences of University of Lisbon, Portugal. Copy Editor Timothy Andrew. Published biannually. Aims and scope: The Western Indian Ocean Journal of Marine Science provides an avenue for the wide dissem- ination of high quality research generated in the Western Indian Ocean (WIO) ...

  10. Style and Variables in English.

    Science.gov (United States)

    Shopen, Timothy, Ed.; Williams, Joseph M., Ed.

    A collection of articles on the kinds of variation in English that one finds within the language of one group or one person includes: "The English Language as Rule-Governed Behavior" (Timothy Shopen); "The English Language as Use-Governed Behavior" (Joseph M. Williams); "Styles" (Ann D. Zwicky); "The Organization…

  11. Lauluga läbi Ameerika 4 / Helle Reinaru

    Index Scriptorium Estoniae

    Reinaru, Helle, 1955-

    2006-01-01

    EELK Misjonikoori kontsertturneest 5.-25. juulini Ameerika Ühendriikides ja Kanadas: jumalateenistusest 16. juulil Missoula St Paul'i luteri kirikus, kontserdist 17. juulil Calvary luteri kirikus, 18. juulil Seattle's Phinney Ridge kirikus, 20. juulil Kanada Scarborough St Timothy anglikaani kirikus ja 21. juulil Toronto baptistikirikus

  12. Air Force Command and Control: The Path Ahead. Volume 1: Summary

    Science.gov (United States)

    2000-12-01

    Hughes Space and Communications Company Dr. Duane A. Adams Vice Provost for Research Carnegie Mellon University Mr. Timothy M. Bonds Analyst...ontology) and a set of callable service interfaces that are matched to the needs of various user communities. What’s needed, therefore, is a

  13. Genesis 2 en 3 in 1 Timoteus 2: ’n motivering vir gedrag in die erediens, die gewone lewe of die huwelik?

    Directory of Open Access Journals (Sweden)

    Douw G. Breed

    2006-07-01

    Full Text Available Genesis 2 and 3 in 1 Timothy 2: a rationale for conduct in public worship, ordinary life, or marriage? In his exegesis of 1 Timothy 2:1-12, Breed (2006:247-261 shows that Paul does not give any indications in this text itself of whether the instructions in verses 8-12 were aimed at regulating conduct during public worship, in ordinary life or marriage. Paul supports the instructions he gives in 1 Timothy 2:11-12 in verses 13-15 by referring to Genesis 2 and 3. This article investigates whether there is any indication in Paul’s rationale of the context in which these instructions should be read. The study focuses on Paul’s reference to the order of creation (v. 13, Eve’s temptation (v. 14a, the state of transgression in which woman finds herself and her salvation by giving birth (v. 14b-15. This study concludes that in his references to Genesis 2 and 3, Paul does not give any indications of whether this instructions in 1 Timothy 2:8-15 deals with instructions for public worship, ordinary life or marriage.

  14. Neokontshennaja pjessa dlja muzõkalnogo avtomata / Nikolai Karajev

    Index Scriptorium Estoniae

    Karajev, Nikolai, 1978-

    2005-01-01

    IX Pimedate Ööde Filmifestivali mängufilme - "Maavärinate klaverihäälestaja" (Piano Tuner of the Earthquakes") : režissöörid Stephen ja Timothy Quay : Suurbritannia - Saksamaa - Prantsusmaa 2005. Režissöörid tutvustasid oma filmi

  15. Vendade Quayde film on nagu ballett / Merit Kask

    Index Scriptorium Estoniae

    Kask, Merit

    2005-01-01

    IX Pimedate Ööde Filmifestivali mängufilme - "Maavärinate klaverihäälestaja" (Piano Tuner of the Earthquakes") : režissöörid Stephen ja Timothy Quay : Suurbritannia - Saksamaa - Prantsusmaa 2005. Režissöörid tutvustasid oma filmi

  16. A long-term follow-up study of hyposensitization with immunoblotting

    DEFF Research Database (Denmark)

    Jarolim, E; Poulsen, L K; Stadler, B M

    1990-01-01

    The formation of specific IgE, IgG1, and IgG4 antibodies was investigated by immunoblotting during hyposensitization with timothy grass-pollen extract and 6 years later, Until the end of immunotherapy, specific IgG antibody levels increased. Also simultaneously, the number of allergenic component...

  17. 76 FR 77728 - Process for a Designated Contract Market or Swap Execution Facility To Make a Swap Available To...

    Science.gov (United States)

    2011-12-14

    ... Mar. 8, 2011 at 2; Letter from Dexter Senft, Morgan Stanley, dated Mar. 2, 2011 at 4; Letter from... from Dexter Senft, Morgan Stanley, dated Mar. 2, 2011 at 4; Letter from Timothy Cameron, Securities... Wayne Pestone, FX Alliance Inc., dated Nov. 4, 2011 at 9-10. \\57\\ Letter from Dexter Senft, Morgan...

  18. The Relationship between the Learning Organization Concept and Firms' Financial Performance: An Empirical Assessment. [and] Invited Reaction: Linking Learning with Financial Performance.

    Science.gov (United States)

    Ellinger, Andrea D.; Ellinger, Alexander E.; Yang, Baiyin; Howton, Shelly W.

    2002-01-01

    Reports on a study of 208 manufacturing managers that found a positive correlation between the seven dimensions of learning organizations and four measures of business financial performance. "Invited Reaction" by Timothy T. Baldwin and Camden C. Danielson critiques the use of key respondent perceptions and bottom-line performance.…

  19. Political Tunings of the Piano

    DEFF Research Database (Denmark)

    Højlund, Marie Koldkjær; Riis, Morten S.

    According to Timothy Morton the creation of ambient art posses an inherent critical potential similar to the ambiguity of the dialectical image found in the writings of Walter Benjamin. Subscribing to an object-oriented ontological understanding of how objects are riven between essence and appear......) as unfolding the ambiguity of various political tunings of the piano....

  20. Military Interventions in Sierra Leone: Lessons from a Failed State

    National Research Council Canada - National Science Library

    Woods, Larry J; Reese, Timothy R

    2008-01-01

    This study by Larry J. Woods and Colonel Timothy R. Reese analyzes the massive turmoil afflicting the nation of Sierra Leone, 1993-2002, and the efforts by a variety of outside forces to bring lasting stability to that small country...