Responsiveness to timothy grass pollen in individuals without known natural exposure in an allergen challenge chamber.

Science.gov (United States)

Ramirez, Daniel A; Andrews, Charles P; Rather, Cynthia G; Jacobs, Robert L

2015-03-01

The responsiveness to a nonendemic grass species is unknown and cannot be research without an allergen challenge chamber. To determine the clinical responsiveness to timothy grass pollen (TGP) in participants without known natural exposure in an allergen challenge chamber (ACC). Of the 26 screened participants, 22 met screening criteria and completed the 2 chamber exposures. The study consisted of an initial screening visit that included a blood draw for serum specific IgE (ssIGE) to Bermuda grass pollen and TGP followed by a 4½-day run-in phase and two 3-hour ACC exposure visits. This study was performed early in the first week of December 2013, when no seasonal pollens were detected in San Antonio, Texas. Symptom scores were recorded at baseline and every 30 minutes. Of the 26 screened participants, 22 met the screening criteria and completed the 2 chamber exposures. Thirteen participants had always lived in South Texas without natural exposure, and 9 had previously lived in areas with TGP exposure. All participants tested positive to TGP and Bermuda grass pollen. Twelve and 13 of 22 had positive ssIgE test results to Timothy and Bermuda allergens, respectively, with 11 having positive results for both allergens. There were strong correlations among skin prick test size, a positive ssIgE test result, and high symptoms from TGP exposure. There was little difference in symptoms between those who had lived their entire lives in South Texas and those who had lived elsewhere. In Texas, where exposure to TGP is minimal, strongly positive SPT and ssIgE test results were predictors of high symptoms to TGP exposure. Never exposed participants in South Texas reacted to TGP similar to those who had previous natural exposure, suggesting that in vivo cross-reactivity may be higher than predicted by prior in vitro data and may allow the use in clinical trials of allergens not endemic to the locale of an ACC. Copyright © 2015 American College of Allergy, Asthma & Immunology

Understanding, Classifying, and Selecting Environmentally Acceptable Hydraulic Fluids

Science.gov (United States)

2016-08-01

traditional mineral oil; therefore, the life cycle costs over time may be reduced . REPLACEMENT OF EXISTING HYDRAULIC FLUIDS: Hydraulic fluids in existing...properly maintaining the fluid can extend the time interval between fluid changes, thus reducing the overall operating cost of the EA hydraulic fluid. It...Environmentally Acceptable Hydraulic Fluids by Timothy J. Keyser, Robert N. Samuel, and Timothy L. Welp INTRODUCTION: On a daily basis, the United States Army

Sequential Treatment Initiation with Timothy Grass and Ragweed Sublingual Immunotherapy Tablets Followed by Simultaneous Treatment Is Well Tolerated.

Science.gov (United States)

Maloney, Jennifer; Berman, Gary; Gagnon, Remi; Bernstein, David I; Nelson, Harold S; Kleine-Tebbe, Jörg; Kaur, Amarjot; Li, Qing; Nolte, Hendrik

2016-01-01

Dual treatment with grass and ragweed sublingual immunotherapy (SLIT) tablets has not been studied. To characterize the safety and tolerability of dual grass and ragweed SLIT-tablet administration. This open-label, multicenter trial (NCT02256553) enrolled North American adults (N = 102) allergic to grass and ragweed. The trial had 3 periods, each of 2 weeks duration. In period 1, subjects received once-daily timothy grass SLIT tablet (2800 bioequivalent allergen unit; Merck, Inc, Kenilworth, NJ/ALK, Hørsholm, Denmark). In period 2, subjects received a short ragweed SLIT tablet (12 Ambrosia artemisiifolia 1-U; Merck/ALK) every morning and a grass SLIT tablet every evening. In period 3, subjects received once-daily grass and ragweed SLIT tablets within 5 minutes (simultaneous intake). The primary end point was the proportion of subjects with 1 or more local swelling events in each period. Secondary end points were the proportion of subjects with 1 or more local adverse events (AEs), that discontinued the treatment because of AEs, and subjects with 1 or more local AEs requiring treatment. No severe swellings, systemic allergic reactions, asthma attacks, or reactions requiring epinephrine were reported. Most (99%) AEs were graded mild to moderate. The proportions of subjects with 1 or more local swelling events were 14%, 22%, and 15% for periods 1, 2, and 3, respectively. For periods 1, 2, and 3, the proportions of subjects with 1 or more local AEs were 71%, 69%, and 56%, respectively; the proportions discontinuing the treatment because of treatment-related AEs were 5%, 1%, and 2%, and the proportions with 1 or more local AEs requiring treatment were 4%, 4%, and 1%. In this trial, a 4-week sequential SLIT-tablet dosing schedule followed by simultaneous intake of timothy grass and ragweed tablets was well tolerated. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

The bacterial population adherent to plant particles in the rumen of reindeer fed lichen, timothy hay or silage

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Monica Alterskjær Olsen

1998-02-01

Full Text Available Male reindeer (Rangifer tarandus tarandus calves taken from a natural winter pasture were given ad lib. access to lichen (n = 3, timothy silage (n = 3 and hay (n = 3 for 7 weeks. Median numbers of viable anaerobic bacteria adherent to the plant particles (cells/g wet weight of rumen solids, growing on a habitat simulating medium (M8V, were significantly higher (P = 0.05 in the rumen of reindeer fed lichen (26.5 x 109- 53.0 x 109 and hay (4.0 x 109- 40.5 x 109, compared to reindeer fed silage (1.15 x 109 - 3.25 x 109. Anaerobic bacterial strains (n = 551 from the plant particles obtained from the rumen of the nine reindeer examined, were isolated using an acid swollen cellulose medium (M8SC and tested for their ability to hydrolyse carboxymethyl cellulose (CMC. The proportion of CMC hydrolysing adherent bacteria isolated from M8SC was significantly higher in reindeer fed hay (21.5% compared ro animals fed lichen (5.3% and silage (2.7% (P = 0.05. The CMC hydrolysing bacterial srrains (n=42 isolated from reindeer fed hay where characterised as non-cellulolytic Butyrivibrio fibrisolvens (9.5%, cellulolytic B. fibrisolvens (50.0%, Clostridium sp. (2.4% and unknowns (38.1%, while CMC hydrolysing strains (n=11 isolated from animals fed lichen and strains (n=4 isolated from animals fed silage where all characterised as B. fibrisolvens. None of the bacterial strains isolated from the rumen solids of reindeer fed lichen or silage were found to be cellulolytic. This study suggests that both lichen and timothy silage have a negative influence, compared to hay, on the numbers of cellulolytic bacteria adherent to the plant particles in the rumen of reindeer.

Complementary DNA cloning of the major allergen Phl p I from timothy grass (Phleum pratense); recombinant Phl p I inhibits IgE binding to group I allergens from eight different grass species

NARCIS (Netherlands)

Laffer, S.; Valenta, R.; Vrtala, S.; Susani, M.; van Ree, R.; Kraft, D.; Scheiner, O.; Duchêne, M.

1994-01-01

BACKGROUND: Grass pollens, such as pollen from timothy grass (Phleum pratense), represent a major cause of type I allergy. OBJECTIVE: In this report we attempted to determine how cross-reactive allergenic components of grass pollens from different species can be represented by a minimum number of

Effect of nitrogen fertilization on the protein quality of timothy grass and silage

Directory of Open Access Journals (Sweden)

Liisa Syrjälä-Qvist

1984-09-01

Full Text Available Timothy grass given N fertilizer at the rates of 40, 80 and 120 kg N/ha was preserved in 3 glass-fibre silos of 0.4 m3. The crude protein content of DM in the grass increased with the increase of N fertilization as follows: N40 14.8 %, N80 18.4 % and N120 22.1 %, but the proportion of true protein in crude protein decreased: N40 82 %, N80 78 % and N120 76 %. The proportion of watersoluble N in the total N in the grass was: N40 27 %, N80 30 % and N120 33 %. The higher was the N fertilization level, the more rapidly was the protein of the grass degraded in the rumen. The amino acid profile of the protein was similar at all the N fertilization levels. The quality of all the silages was good. The NH3-N fraction of total N was 2.8—3.9 % and the proportion of water-soluble N in total N was 51—55 %, In silage the decrease during ensiling in the proportion of true protein in crude protein and the increase in the proportion of water-soluble N in total N were smaller than in the other silages. The rumen degradability of protein during the first two hours was also lowest in this silage.

MUSLIM-CHRISTIAN DEBATES IN THEEARLY ‘ABBASID PERIOD: The Cases of Timothy I and Theodore Abu Qurra

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Hans Abdiel Harmakaputra

2014-12-01

Full Text Available The era of the early ‘Abbasid caliphate made an important mark on the history of the world by the event of the Greek translation movement, i.e. the translation of Greek thoughts into the Arabic language. In addition to this development, the era also saw the flourishing of interreligious discourse, in both polemical literatures and religious debates, especially between Christians and Muslims. This article tries to describe how those two historical remarks are correlated under the light of other factors such as politics and religious identity. The earliest debate was happened between caliph al-Mahdi (r. 755-785 CE and a Nestorian Catholicos, Timothy I (728- 823 CE, as the first sample of religious discourses. The second one is the debate between the caliph al-Ma’mun (r. 813-833CE, who arranged many religious debates in his court, with Theodore Abu Qurra (755 – 830 CE, Bishop of Harran. By knowing the motives of the two caliphs who sponsored those events, readers would catch a better picture of the historical contexts of that time.

Obituary: Timothy Hawarden (1943-2009)

Science.gov (United States)

Robson, Ian

2011-12-01

British astronomy lost one of its most respected and liked members with the sudden death of Dr Timothy (Tim) Hawarden. Hawarden was one of those people who changed his wavelength and discipline as the emerging challenges of astronomy dictated, and was successful in all of his ventures. He experienced a huge breadth of achievement; moving from photographic plates, through electronic detectors to infrared astronomy from the ground and subsequently from space. He was an acknowledged leader in his fields around the world and, in addition to his professional accomplishments, he was a keen practitioner of culinary technique. His bouillabaisse was legendary. In his later years he was a source of inspiration for young children in his outreach work. Tim Hawarden began his career as an optical astronomer in South Africa. He graduated from the University of Natal, Pietermaritzburg in 1966 with a BSc in Physics and Applied Mathematics, followed by an MSc in Astronomy from the University of Cape Town in 1970 and a PhD in 1975. Hawarden's early years were formed by learning the precise art of photometry from the legendary Cousins, and this focus on precision has stood him in good stead throughout his career. He then moved Australia in 1975, where he spent three years as Deputy Astronomer-in-Charge of the UK Schmidt Telescope, from where he moved to the Royal Observatory Edinburgh, where he remained for the rest of his career. Hawarden rapidly moved into the newly emerging field of infrared astronomy. His research moved from stars and stellar clusters to barred spiral galaxies and he was keen to employ the new tools coming on-line to pursue this work. The United Kingdom Infrared Telescope (KIRT) was the world's premier facility and Tim Hawarden became the Head of the unit at the ROE in 1981, a post he held for the next six years, overseeing a range of developments that have stood the test of time and have provided the platform on which UKIRT has retained its world-class standing

Safety of sublingual immunotherapy Timothy grass tablet in subjects with allergic rhinitis with or without conjunctivitis and history of asthma

DEFF Research Database (Denmark)

Maloney, J; Durham, S; Skoner, D

2015-01-01

BACKGROUND: Patients with asthma may be more susceptible to adverse events (AEs) with sublingual immunotherapy tablet (SLIT-tablet) treatment, such as severe systemic reactions and asthma-related events. Using data from eight trials of grass SLIT-tablet in subjects with allergic rhinitis with....../without conjunctivitis (AR/C), AE frequencies were determined in adults and children with and without reported asthma. METHODS: Data from randomized, double-blind, placebo-controlled trials of Timothy grass SLIT-tablet MK-7243 (2800 BAU/75 000 SQ-T, Merck/ALK-Abelló) were pooled for post hoc analyses. Subjects...... with asthma treated with grass SLIT-tablet versus subjects without asthma in or outside of pollen season. There were 6/120 asthma-related TRAEs assessed as severe with grass SLIT-tablet and 2/60 with placebo, without a consistent trend among subjects with and without asthma (5 and 3 events, respectively...

Timothy Leary, Richard Alpert (Ram Dass) and the changing definition of psilocybin.

Science.gov (United States)

Wark, Colin; Galliher, John F

2010-05-01

This research focuses on the events leading to the 1968 U.S. federal prohibition of psilocybin. It is a study of duelling moral entrepreneurs-Timothy Leary and Richard Alpert vs. the Harvard University Administration. The goal is to show how the primary active compound in an ostensibly harmless fungus (the psilocybin mushroom) became controversial in less than a decade. We used books, newspapers, magazine articles and previously unpublished materials (including documents from the Harvard Archives) to analyze Leary and Alpert's lives and careers through the early 1970s. The prohibition of psilocybin in the U.S. was largely a product of Leary and Alpert's involvement in the "Harvard drug scandal" and their transformation from Harvard professors to countercultural icons. They tested the substance on a variety of human subjects and in doing so piqued the interest of Harvard undergraduates while drawing condemnation from other faculty and Harvard administrators. This case is theoretically interesting because unlike most illegal drugs, psilocybin was never linked to a threatening minority group, but to some of the nation's most privileged youth. The Harvard administrators were not really moral entrepreneurs but Leary and Alpert clearly were. Although they were far from being prohibitionists, they were self-righteous crusaders on different but equally holy missions for the good of young and minority Americans. Ironically, due to their successes the possession of psilocybin was criminalized under United States federal law in 1968 (Pub. L. No. 90-639, Stat. 1361 1968 and Boire, 2002). This case study demonstrates that crusaders can be successful in changing culture even when laws are passed in futile attempts to control their behaviour, just as Leary predicted. Copyright 2009 Elsevier B.V. All rights reserved.

Comments on Timothy F. Murphy's 'the afterlife of embryonic persons: what a strange place heaven must be'.

Science.gov (United States)

Head, Ivan F

2012-12-01

In this issue, Timothy F. Murphy has written a thought-provoking and carefully nuanced article that focuses on the question of a link between a first moment of conception and an end-state beyond death in the resurrection of a human person. He is particularly concerned to probe the theological implications of asserting that the person exists from the moment of conception, and he does so by asking the reader to imagine what kind of resurrected persons would thus populate a heaven filled with, for instance, the resurrected that had in this biotic life lived but a few hours post conception, or had, say, a CV that covered no more than 5 days of cellular replication. By implication, he asks us to imagine a resurrected person whose earthly life lacked memory, consciousness or bodily form, and rather had persisted as a cluster of undifferentiated pluripotent cells. Murphy's candid and fair treatment of these topics is a helpful invitation to some theologians to follow more thoroughly all implications of dogmatically held positions and to consider more thoroughly new ways of thinking of the person as an emergent reality. Copyright © 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

Effect of dexmedetomidine added to spinal bupivacaine for urological procedures

International Nuclear Information System (INIS)

AlMustafa, Mahmoud M.; AbuHalaweh, Sami A.; Aloweidi, AbdelKarim S.; Murshidi, Mujalli M.; Ammari, Bassam A.; Awwad, Ziad M.; AlEdwan, Ghazi M.; Ramsay, Micheal A.

2009-01-01

To determine the effect of adding dexmedetomidine to bupivacaine for neuraxial anesthesia. Sixty-six patients were studied between April and May 2008 in the University of Jordan, Amman Jordan. They were randomly assigned into 3 groups, each receiving spinal bupivacaine 12.5mg combined with normal saline (group N) Dexmedetomidine 5ug (group D5), or dexmedetomidine 10ug (group D10). The onset times to reach T10 sensory and Bromage 3 motor block, and the regression times to reach S1 sensory level and Bromage 0 motor scale, were recorded. The mean time of sensory block to reach the T10 dermatome was 4.7 +/- 2.0 minutes in D10 group, 6.3+/-2.7 minutes in D5, and 9.5+/-3.0 minutes in group N. The mean time to reach Bromage 3 scale was 10.4+/-3.4 minutes in group D10, 13.0+/-3.4 minutes in D5, and 18.0+/-3.3 minutes in group N. The regression time to reach S1 dermatome was 338.9+/-44.8 minutes in group D10, 277.1+/-23.2 minutes in D5, and 165.5+/-32.9 minutes in group N. The regression to Bromage 0 was 302.9+/-36.7 minutes in D10, 246.4 +/-25.7 minutes in D5, and 140.1+/-32.3 minutes in group N. Onset and regression of sensory and motor block were highly significant (N vesus D5, N versus D10, and D5 versus D10, p<0.001). Dexmedetomidine has a dose dependant effect on the onset and regression of sensory and motor block when used as an adjuvant to bupivacaine in spinal anesthesia. (author)

A highly active endo-levanase BT1760 of a dominant mammalian gut commensal Bacteroides thetaiotaomicron cleaves not only various bacterial levans, but also levan of timothy grass

DEFF Research Database (Denmark)

Mardo, Karin; Visnapuu, Triinu; Vija, Heiki

2017-01-01

of Pseudomonas syringae pv. tomato, its mutant Asp300Asn, levansucrases of Zymomonas mobilis, Erwinia herbicola, Halomonas smyrnensis as well as on levan isolated from timothy grass. For the first time a plant levan is shown as a perfect substrate for an endo-fructanase of a human gut bacterium. BT1760 degraded...... levans to FOS with degree of polymerization from 2 to 13. At optimal reaction conditions up to 1 g of FOS were produced per 1 mg of BT1760 protein. Low molecular weight (grass levan and levan synthesized from sucrose by the Lsc3Asp300Asn, were degraded most rapidly...... whilst levan produced by Lsc3 from raffinose least rapidly. BT1760 catalyzed finely at human body temperature (37°C) and in moderately acidic environment (pH 5-6) that is typical for the gut lumen. According to differential scanning fluorimetry, the Tm of the endo-levanase was 51.5°C. All tested levans...

Habitat selection by female northern pintails wintering in the Grassland Ecological Area, California

Science.gov (United States)

Fleskes, Joseph P.; Gilmer, David S.; Jarvis, Robert L.

2004-01-01

To determine relative importance of habitats available in the Grassland Ecological Area (GEA) to wintering female northern pintails, Anas acuta, we studied habitat use relative to availability (i.e., habitat selection) in the GEA during September through March, 1991-94 for 196 Hatch-Year (HY) and 221 After-Hatch-Year (AHY) female pintails that were radio tagged during August-early October in the GEA (n = 239), other San Joaquin Valley areas (n = 132), or other Central Valley areas (n = 46). Habitat availability and use varied among seasons and years, but pintails always selected shallow and, except on hunting days, open habitats. Swamp timothy, Heleochloa schoenoides, marsh was the most available, used, and selected habitat. Watergrass, Echinochloa crusgalli, marsh in the GEA was used less than available at night in contrast to previous studies in other SJV areas. Preferred late-winter habitats were apparently lacking in the GEA, at least relative to in the Sacramento Valley and Delta where most pintails moved to in December each year. Impacts on pintails of the increasing practice of managing marshes for increased emergent vegetation to attract other species should be monitored. Shallow, open habitats that produce seeds and invertebrates available to pintails in late winter would help maintain pintail abundance in the GEA.

‘The woman was deceived and became a sinner’ – a literary-theological investigation of 1 Timothy 2:11–15

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Abiola I. Mbamalu

2014-07-01

Full Text Available In 1 Timothy 2:11–15 women are forbidden to teach and have authority over men in the church. The ground for this instruction is the creation account in Genesis 2 that asserts the priority of Adam over Eve in the order of creation. The second reason for the instruction is the deception of Eve according to the account of the Fall in Genesis 3. This pericope has elicited arguments between advocates of egalitarianism and complementarianism revolving over the issues of grammar, the context of the Ephesian church with regard to false teachings and the comparison of this text with the other writings of Paul, for those that subscribe to the authorship of Paul. The contention of this article is that verse 15 provides a major clue as to how this text should be understood. In addition, the author’s rhetoric in this text is interrogated with regard to the text’s own internal literary and theological logic. In this regard, the author is found to be inconsistent in his outlook, for the grace that was poured out abundantly on him: a blasphemer, a persecutor and a violent man and on account of his ignorance andunbelief (1 Tm 1:12–16 is apparently, being denied women on account of Eve’s deception.

Congenital hearing loss. Is CT enough?

African Journals Online (AJOL)

Mahmoud Agha

2014-01-24

Jan 24, 2014 ... children have potential impact on child educational, cognitive and social development. .... nerstone for management planning. It guides the selection of ..... 7. Timothy C.Hain. Congenital deafness. http://www.dizziness-and-.

Seed germination and seedling vigour of italian ryegrass, cocksfoot and timothy following harvest and storage Germinação de sementes e o vigor de plantas jovens de azevem italiano, dactilis e timóteo após a colheita e o armazenamento

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Rade Stanisavljevic

2011-12-01

Full Text Available During post-harvest maturation, different species vary in the length of dormancy breaking or germination increases. Seed dormancy and slow seedling development often limit establishment of forage grass stands. Seed germination and seedling vigour of Italian ryegrass (Lolium italicum A. Braun, Synonym Lolium multiflorum L., cocksfoot (Dactylis glomerata L. and timothy (Phleum pretense L. were observed after harvest and storage. After harvest in June, seeds were stored under standard storage conditions and sampled every 30 days after harvest (DAH, up to 270 DAH, and then every 60 days up to 990 DAH. At each date, seeds were tested for final germination percentage and for seedling vigour traits. Timothy seeds had a maximum germination (88% and the best seedlings vigour at 90 DAH, which implies that early autumn (September-October is the best sowing period for freshly harvested seeds of timothy. Timothy seed germination was poor from 270 DAH (73%. The best germination and vigour of Italian ryegrass and cocksfoot seedlings were between 270 and 330 DAH, which equates to spring sowing time (March-April in the succeeding year. Cocksfoot and Italian ryegrass seeds maintained satisfactory germination levels up to 630 DAH (81% and 810 DAH (81%, respectively. The data can serve for the determination of a proper storage duration management between harvest and sowing of the tested species under ambient conditions of south-eastern Europe.Durante o armazenamento, diferentes espécies comportam-se diferentemente quanto à dormência e crescimento de plântulas. A dormência o desenvolvimento lento das plântulas limitam a época do plantio das gramíneas forrageiras plurianuais. A germinação de sementes e o crescimento das plântulas de azevem italiano (Lolium italicum A. Braun sin. Lolium multiflorum L., Dactilis (Dactilis glomerata L. e de timoteo (Phleum pratense L. foi pesquisada durante a maturação pós-colheita e a silagem. Após a colheita, em junho

and the quality of silage

Directory of Open Access Journals (Sweden)

Liisa Syrjälä-Qvist

1984-09-01

Full Text Available Five silages having different proportions of red clover and timothy (100/0, 75/25, 50/50, 25/75 and 0/100 were preserved in five glass-fibre silos of 0.4 m 3. Chopped red clover and timothy were mixed during ensiling and preserved with AIV II solution (80 % formic acid and 2 % orthophosphoric acid, applied at the rate of 6 l/1000kg fresh material. The timothy sward was fertilized with 100kg N/ha and the red clover with 15kg N/ha. The dry matter content in red clover was 14.5 % and in timothy 18.6%, and the crude protein content of DM 22.9 % and 11.5 %, respectively. True protein formed 75—76 % of crude protein in both herbages and the proportion of watersoluble N in total N was 32 % in red clover and 36 % in timothy. The rumen degradability of protein during the first two hours was under 10 % in both herbages; after 18 and 24h ours it was 76 % and 87 % in red clover, and 65 % and 70 % in timothy. In red clover the contents of lysine, methionine and cysteine were 5.7 g, 0.4 g and 0.9 g/16 g N, respectively, the corresponding values for timothy being 4.8 g, 0.7 g and 1.4g/16 g N. In red clover the content of water-soluble carbohydrates was 10.6 % of DM and in timothy 16.5 %; the contents of plant acids were 6.7 % and 3.5 % of DM, respectively. Red clover contained 10.9g Ca/kg DM and timothy 3.1 g Ca. The total amount of inorganic constituents was also higher in red clover than in timothy. Although the chemical composition of red clover was less suitable for ensiling than the composition of timothy, the quality of all the silages was good. During ensiling the decrease in the proportion of true protein in crude protein and the increase in the proportion of watersoluble N in total N were smaller in red clover than in timothy silage. These changes were reflected in the ruminal protein degradation, which seemed to be slower when they were small. The amino acid profile of the protein did not alter during ensiling. The ensiling losses were higher in

Comparative study of transgenic Brachypodium distachyon expressing sucrose:fructan 6-fructosyltransferases from wheat and timothy grass with different enzymatic properties.

Science.gov (United States)

Tamura, Ken-Ichi; Sanada, Yasuharu; Tase, Kazuhiro; Kawakami, Akira; Yoshida, Midori; Yamada, Toshihiko

2014-04-01

Fructans can act as cryoprotectants and contribute to freezing tolerance in plant species, such as in members of the grass subfamily Pooideae that includes Triticeae species and forage grasses. To elucidate the relationship of freezing tolerance, carbohydrate composition and degree of polymerization (DP) of fructans, we generated transgenic plants in the model grass species Brachypodium distachyon that expressed cDNAs for sucrose:fructan 6-fructosyltransferases (6-SFTs) with different enzymatic properties: one cDNA encoded PpFT1 from timothy grass (Phleum pratense), an enzyme that produces high-DP levans; a second cDNA encoded wft1 from wheat (Triticum aestivum), an enzyme that produces low-DP levans. Transgenic lines expressing PpFT1 and wft1 showed retarded growth; this effect was particularly notable in the PpFT1 transgenic lines. When grown at 22 °C, both types of transgenic line showed little or no accumulation of fructans. However, after a cold treatment, wft1 transgenic plants accumulated fructans with DP = 3-40, whereas PpFT1 transgenic plants accumulated fructans with higher DPs (20 to the separation limit). The different compositions of the accumulated fructans in the two types of transgenic line were correlated with the differences in the enzymatic properties of the overexpressed 6-SFTs. Transgenic lines expressing PpFT1 accumulated greater amounts of mono- and disaccharides than wild type and wft1 expressing lines. Examination of leaf blades showed that after cold acclimation, PpFT1 overexpression increased tolerance to freezing; by contrast, the freezing tolerance of the wft1 expressing lines was the same as that of wild type plants. These results provide new insights into the relationship of the composition of water-soluble carbohydrates and the DP of fructans to freezing tolerance in plants.

Prospective Randomized Controlled Comparison of Caudal ...

African Journals Online (AJOL)

including 50 consecutive patients in the age group of 1‑10 years, who underwent urogenital surgeries ... The duration of absolute analgesia was defined as the time from caudal injection until the pain score was >2. Motor block was assessed by modified Bromage scale. .... double-blind, phase III, controlled trial comparing.

罗哌卡因与布比卡因硬膜外自控镇痛的比较研究%Comparison of Ropivacaine and Bupivacaine for Postoperative Patient- controlled Epidural Analgesia

Institute of Scientific and Technical Information of China (English)

徐建設; 陳仲清; 廖志婕

2002-01-01

Objective To compare the characteristics of ropivacaine with bupivacaine for postoperative patient-controlled epidural analgesia(PCEA).Method Sixty epidural anesthesia patients (ASA Ⅰ～Ⅱ ) scheduled for low abdominalsurgery were divided into two groups randomly to receive 0.125% ropivacaine or0.125% bupivacaine for postoperative patient-controlled epidural analgesia respectively. A bolus doses of 5ml with 30min lockout and a continuous dose of 2ml/h weregiven within 48 hours after surgery. Analgesic efficacy was assessed using 100mm visual analog pain scores (VAS) ,and motorblock was assessed using Bromage score. Volume of the epidural infusion and number of patients requesting supplementaryanalgesics were recorded. Result There were no significant differences between groups in pain scores, volume of the epiduralinfusion and number of patients requesting supplementary analgesics (P ＞ 0.05). But there was higher incidence of zeroBromage score at some time and mobilization recovered more quickly in ropivacaine group. Conclusion Comparing withbupivacaine,0. 125 % ropivacaine may produce equivalent anaglesia, less motor block and early recovery of mobilization forpostoperative (PCEA).

Semi Quantitative MALDI TOF for Antimicrobial Susceptibility Testing in Staphylococcus aureus

Science.gov (United States)

2017-08-31

Semi- quantitative MALDI-TOF for antimicrobial susceptibility testing in Staphylococcus 1 aureus 2 3 4 Tucker Maxson,a Cheryl L. Taylor-Howell,a...Timothy D. Minoguea# 5 6 Diagnostic Systems Division, United States Army Medical Research Institute of Infectious 7 Disease, Fort Detrick, MD...USAa 8 9 Running Title: Quantitative MALDI for AST in S. aureus 10 #Address correspondence to Timothy D. Minogue, timothy.d.minogue.civ@mail.mil

Timothy Garton Ash : eurovalimiste tulemus hakkab meenutama loomaaeda / Timothy Garton Ash

Index Scriptorium Estoniae

Garton Ash, Timothy, 1955-

2009-01-01

Intervjuu Briti ajaloolase ja politoloogiga praegusest kriisist, protektsionismist, Euroopast ja selle ühtsuse suurendamise vajadusest, Euroopa Parlamendist ja selle valimistest, Euroopa Liidust. Professori arvates võiks kaaluda Euroopa Nõukogu ja Euroopa Komisjoni presidendi otsevalimist

Gross anatomy of the gastrointestinal tract in reindeer, free-living and fed baled timothy silage in summer and winter

Directory of Open Access Journals (Sweden)

Tove H. Aagnes

1996-01-01

Full Text Available The gross anatomy of the gastrointestinal (GI tract was investigated in reindeer calves (Rangtfer tarandus tarandus, free-living and fed two different qualities of timothy silage in September 1992 (summer and April 1993 (winter and related to the body condition. At both seasons nine male reindeer calves were taken from a natural pasture. Three animals were slaughtered directly (NP reindeer, three offered first cut (FC silage and three regrowth (RG silage ad lib., for 46 days. The FC silage contained 27% leaves and 57.8% dry matter (DM cell wall content (CWC and the RG silage 89 % leaves, and 38.7% DM CWC. The reticulo-rumen (RR digesta wet weight in the NP reindeer in summer was 6.7-7.7% of body mass (BM, compared to 25.1-32.8% and 9.6-12.9% of BM, respectively, in the animals fed FC and RG silage. In winter the RR digesta wet weight relative to BM in the NP reindeer and in the animals fed FC and RG silages were 9-5-11.5%, 25.4-33.3% and 10.4-18.3%, respectively. The distal fermentation chamber (DFC digesta wet weight in the NP animals in summer was 0.48-0.80% of BM, compared to 0.77-1.26% and 0.57¬0.65% of BM, respectively, in the animals fed FC and RG silage. In winter the DFC digesta wet weight relative to BM in the animals fed FC and RG silage did not differ significantly from the summer values (P>0.05, while in the NP reindeer it was 1.0-1.2% of BM which is significantly greater than in summer (P<0.05. The differences in relative weight of the fermentation chambers between the animals fed FC and RG silage both summer and winter were not reflected in total BM, which was similar in all groups fed silage. This is explained by a significantly lower carcass weight in the animals fed FC silage compared to the animals fed RG silage. Thus, the GI-tract gross anatomy in the silage fed animals seem to be highly affected by the plant structure and composition, and not by the season.

Triggers of Violence in New Religious Movements

Science.gov (United States)

2012-12-01

71Brandon M. Stickney, All-American Monster: The Unauthorized Biography of Timothy McVeigh (New York: Prometheus Books, 1996), Kindle edition, 1503...and the one who was to rebuild the temple in Jerusalem just as Solomon had after his father’s death.85 Infighting between the two continued in... Biography of Timothy McVeigh. Amherst, NY: Prometheus Books, 1996. Kindle Edition. Toft, Monica, Daniel Philpott, and Timothy Shah. God’s Century. New

78 FR 77772 - Shipping Coordinating Committee; Notice of Committee Meeting

Science.gov (United States)

2013-12-24

... emissions of Black Carbon from international shipping --Review of relevant non-mandatory instruments as a... should contact the meeting coordinator, Mr. Timothy Brown, by email at timothy.m.brown@uscg.mil , by...

78 FR 73898 - Operator Licensing Examination Standards for Power Reactors

Science.gov (United States)

2013-12-09

[email protected] . Both of the Office of New Reactors; or Timothy Kolb, Office of Nuclear Reactor Regulation, U...: timothy.kolb@nrc.gov . SUPPLEMENTARY INFORMATION: I. Accessing Information and Submitting Comments A...

Army Science Conference Proceedings Held in Orlando, Florida on June 22 - 25, 1992. Volume 3, Principal Authors N Through Z.

Science.gov (United States)

1992-06-25

Cooke, P. W. I 291 Evans, Timothy D. See Hansen, John V.E. II 1 Ezzell , John W. See Friedlander, Arthur I 445 Fazi, C. Observation of rf-Induced I 421...resolution cf the NO’ ion sigr--! c,, mile -- 30. A total selectivity value of 5 x 105 is obtained when using values of 500 nm and 0.001 nm for RREMPI

77 FR 17116 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

Science.gov (United States)

2012-03-23

...), Michael R. Miller (PA), Jack L. Phippen (WI), Richard A. Purk (CA), Timothy M. Rearick (PA), Jeremy Simmons (MA), Jack A. Tidey (AK), Brian E. Quick (VA) and Timothy W. Work (NY) from the ITDM requirement...

Ainuke püsiv asi on muutumine / Anneliis Aunapuu

Index Scriptorium Estoniae

Aunapuu, Anneliis

2008-01-01

Taani audiovideotehnikat disainivast firmast Jacob Jensen Design. Jacob Jenseni (sünd. 1926) asutatud büroo loomingut tutvustab tema poeg Timothy Jacob Jensen (sünd. 1962). Eesti disaini tasemest, Jaapani disainitoodangust. Esikaanel ja lk. B3 fotod Timothy Jacob Jensenist

Technique Development Results for the Study of a Novel Dexamethasone Impregnated Bandage Contact Lens in a Rabbit Model After Photorefractive Keratectomy

Science.gov (United States)

2017-10-22

PRK Inflammation in a Rabbit Model Timothy A. Soekenl, Michael Merkley!, Wesley Brundridgel, Gary Legaultl, Matthew Caldwelll, Joseph Ciolino2...7 .0 Dexamethasone Impregnated Contact Lenses in the Treatment of Post- PRK Inflammation · in a Rabbit Model Timothy A. Soeken 1, Michael Merkley1

76 FR 71370 - Silviu Ziscovici, M.D.; Decision and Order

Science.gov (United States)

2011-11-17

....; Decision and Order On December 10, 2010, Administrative Law Judge (ALJ) Timothy D. Wing, issued the... record in its entirety including the ALJ's recommended decision, I have decided to adopt the ALJ's... Administrative Law Judge Timothy D. Wing, Administrative Law Judge. This proceeding is an adjudication governed...

Alpha-tocopherol and β-carotene in legume-grass mixtures as influenced by wilting, ensiling and type of silage additive

DEFF Research Database (Denmark)

Lindqvist, H; Nadeau, E; Jensen, Søren Krogh

2012-01-01

Effects of wilting, ensiling and type of additive on α-tocopherol and β-carotene contents in legume–grass mixtures were examined. Swards of birdsfoot trefoil + timothy (Bft + Ti), red clover + timothy (Rc + Ti) and red clover + meadow fescue (Rc + Mf) were harvested as a first regrowth in August...

Identifying Local Benefits of Early Childhood Development Programs Using Regional Modeling

Science.gov (United States)

Temple, Judy A.; Rolnick, Arthur J.

2012-01-01

This article presents a review of "Investing in Kids: Early Childhood Programs and Local Economic Development" by Timothy J. Bartik. Timothy Bartik's timely book contributes to an important conversation about the role of government in promoting investments in children in the years before traditional public schooling typically begins. Until…

Thresholds, injury, and loss relationships for thrips in Phleum pratense (Poales: Poaceae).

Science.gov (United States)

Reisig, Dominic D; Godfrey, Larry D; Marcum, Daniel B

2009-12-01

Timothy (Phleum pratense L.) is an important forage crop in many Western U.S. states. Marketing of timothy hay is primarily based on esthetics, and green color is an important attribute. The objective of these studies was to determine a relationship between arthropod populations, yield, and esthetic injury in timothy. Economic injury levels (EILs) and economic thresholds were calculated based on these relationships. Thrips (Thripidae) numbers were manipulated with insecticides in small plot studies in 2006, 2007, and 2008, although tetranychid mite levels were incidentally flared by cyfluthrin in some experiments. Arthropod population densities were determined weekly, and yield and esthetic injury were measured at each harvest. Effects of arthropods on timothy were assessed using multilinear regression. Producers were also surveyed to relate economic loss from leaf color to the injury ratings for use in establishing EILs. Thrips population levels were significantly related to yield loss in only one of nine experiments. Thrips population levels were significantly related to injury once before the first annual harvest and twice before the second. Thrips were the most important pest in these experiments, and they were more often related to esthetic injury rather than yield loss. EILs and economic thresholds for thrips population levels were established using esthetic injury data. These results document the first example of a significant relationship between arthropod pest population levels and economic yield and quality losses in timothy.

Book Review: "Indigenous Peoples of the British Dominions and the ...

African Journals Online (AJOL)

Book Review: "Indigenous Peoples of the British Dominions and the First World War"by Timothy C. Winegard. ... Timothy Winegard saw active duty in the Canadian Reserve Force from 2001 to 2010 and served on detachment duty to the British Army for a two-year period. He obtained various academic degrees from 1999 ...

Book Review: The future of spacetime. Stephen William Hawking (ed.); Kip S. Thorne, Igor Novikov, Timothy Ferris, Alan Lightman, and Richard Price, W.W. Norton & Company, 2002, 224 pp., US 25.95, ISBN 0393020223

Science.gov (United States)

Smeenk, Chris

2003-12-01

The study of Einstein's theory of general relativity experienced a renaissance beginning in the early 1960s. Prior to this resurgence of interest, general relativity was isolated from mainstream physics-admired for its elegance, perhaps, but only from a distance. The generation of students who risked their careers by entering this neglected field has now reached the age of festschrifts. In June of 2000, Caltech hosted ;Kipfest,; a conference in honor of Kip Thorne's 60th birthday. Thorne started graduate school at Princeton in 1962 and began research in general relativity under John Wheeler's guidance in the heady early days of the renaissance. Since then, he has played a prominent role in general relativity: as co-author of the influential textbook Gravitation, as a leader in research regarding astrophysical applications of Einstein's theory, and as a co-founder and chief advocate for the Laser Interferometer Gravitational Wave Observatory (LIGO), to mention a few aspects of his far-reaching work. ;Kipfest; included 14 speakers discussing fields to which Thorne has contributed. But the conference also reflected Thorne's long-standing commitment to communicating science to a general audience: Igor Novikov, Stephen Hawking, Timothy Ferris, and Alan Lightman gave popular talks at ;Kipfest,; with Thorne himself tricked into delivering a fifth. The Future of Spacetime gathers adaptations of these five lectures, along with a lengthy introductory essay by Richard Price.

77 FR 12883 - Announcement of Public Briefings on the Changes to the Labor Certification Process for the...

Science.gov (United States)

2012-03-02

... these steps: To join the March 14 Webinar, please go to: https://dol.webex.com/dol/onstage/g.php?d... 20 Webinar, please go to: https://dol.webex.com/dol/onstage/g.php?d=647498716&t=a&EA=erskine.timothy....webex.com/dol/onstage/g.php?d=644379778&t=a&EA=erskine.timothy%40dol.gov&ET...

Design and Analysis of an Attitude Determination and Control Subsystem (ADCS) for AFIT’s 6U Standard Bus

Science.gov (United States)

2014-03-27

solenoid in Eq. 3.2 [49]. M = nIA (3.2) where n is the number of turns of the wire, I is the current going through the wire, and A is the cross...Bldg 497 Kirtland AFB, NM 87117 Timothy J. Shuck, Capt, USAF, ( 505 ) 853-4513, timothy.shuck@kirtland.af.mil AFRL/RVES 12. DISTRIBUTION / AVAILABILITY

Keeping Our Eyes Open: Conducting Aerial Reconnaissance Without Space

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2016-05-01

TIMOTHY M. CULLEN (Date) ___________________________________ JAMES M. TUCCI (Date) iii DISCLAIMER The...in 2014/15, and USAF School of Advanced Air and Space Studies in 2015/16. v ACKNOWLEDGMENTS I would like to thank Colonel Timothy Cullen for...Admiral William Owens. In 1996 Owens described ISR as involving “sensor and reporting technologies associated with intelligence collection

Space Theory and Strategy: War From the High Ground Down

Science.gov (United States)

2016-06-01

M.V. “COYOTE” SMITH (Date) __________________________________________ COLONEL TIMOTHY CULLEN (Date) iii...reader, Colonel Timothy Cullen , I would like to express my gratitude for the insightful suggestions to this work. To the ultimate sounding board... William L. Shelton, “Military Space: A Strategic Crossroad,” Air & Space Power Journal (September-October 2013): 5-6, War From the High Ground Down

Pavel Aleksadrovič Florenskij's method of discerning spiritual truth ...

African Journals Online (AJOL)

The article also provides an intertextual reading of Florenskij's Pillar to argue that its context is 1 Timothy 3:14-16. It then analyses the similarities between the context of 1 Timothy and that of The Pillar. As they fall within a period during which particular churches faced certain challenges, both texts call for discernment of the ...

COMPARISON BETWEEN FENTANYL 2 μG/mL VERSUS DEXMEDETOMIDINE 1.5 μG/mL AS ADJUVANTS WITH ISOBARIC BUPIVACAINE 0.0625% IN EPIDURAL LABOUR ANALGESIA

Directory of Open Access Journals (Sweden)

Karuna Harsoor

2016-11-01

Full Text Available BACKGROUND Low-dose bupivacaine with opioids like fentanyl have been used traditionally as an adjunct for epidural labour analgesia, but has side effects like pruritus, urinary retention, nausea, vomiting, etc. Dexmedetomidine, an α-2 adrenergic agonist with a high placental retention, decreased sympathetic outflow and norepinephrine release thereby causing sedation, anxiolysis, analgesia, sympatholysis and maternal haemodynamic stability. Hence, this study was carried out to compare dexmedetomidine and fentanyl as adjuvants in epidural labour analgesia. MATERIALS AND METHODS A prospective randomised, double-blind study was conducted in 60 term parturients in active labour of ASA I and II physical status. They were randomised into 2 groups with 30 parturients in each and received 15 mL of 0.0625% Inj. Bupivacaine plus either 1.5 μg/mL Inj. Dexmedetomidine (BD group or 2 μg/mL Inj. Fentanyl (BF group. VAS, sedation scores, modified four grade Bromage scale, haemodynamics, peripheral oxygen saturation were recorded at baseline and regular intervals. When VAS was ≥4, subsequent doses of 5 mL of the respective group drug was administered. Parturients were ambulated when Bromage scale was 0 with no postural hypotension. Duration of analgesia, labour outcome, neonatal Apgar scores and side effects were noted. RESULTS Demography and haemodynamic stability were similar and comparable. Duration of analgesia was significantly longer in BD group (131.83±45.760 than BF group (85.33±22.512 (p<0.0001. More no. of top-ups was needed in BF group (1.80±1.518 than BD group (0.17±0.461 (p<0.0001. Significantly reduced VAS scores was observed in BD group than BF group. Mean sedation scores (p<0.05 and maximum Bromage scores (p=0.004 were significantly higher in BD group than BF group. Ambulation was less in BD group (3 parturients than BF group (26 parturients. Side effects were significantly more in BF group than BD group (p=0.007. The labour outcomes

From Power Projection To Power Protection: Revitalizing Conventional Deterrence In NATO

Science.gov (United States)

2016-06-01

Col TIMOTHY M. CULLEN _____________________________ Dr. RICHARD R. MULLER ii DISCLAIMER The conclusions and opinions expressed in...ACKNOWLEDGMENTS I would like to thank my thesis advisor, Col Timothy Cullen , who helped me structure my rough ideas within the framework of...a neighboring country (as in the case of Iraq’s seizure of Kuwait) is extremely difficult to reverse. Alexander George and William Simons Old

Genesis 2 en 3 in 1 Timoteus 2: ’n motivering vir gedrag in die erediens, die gewone lewe of die huwelik?

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Douw G. Breed

2006-07-01

Full Text Available Genesis 2 and 3 in 1 Timothy 2: a rationale for conduct in public worship, ordinary life, or marriage? In his exegesis of 1 Timothy 2:1-12, Breed (2006:247-261 shows that Paul does not give any indications in this text itself of whether the instructions in verses 8-12 were aimed at regulating conduct during public worship, in ordinary life or marriage. Paul supports the instructions he gives in 1 Timothy 2:11-12 in verses 13-15 by referring to Genesis 2 and 3. This article investigates whether there is any indication in Paul’s rationale of the context in which these instructions should be read. The study focuses on Paul’s reference to the order of creation (v. 13, Eve’s temptation (v. 14a, the state of transgression in which woman finds herself and her salvation by giving birth (v. 14b-15. This study concludes that in his references to Genesis 2 and 3, Paul does not give any indications of whether this instructions in 1 Timothy 2:8-15 deals with instructions for public worship, ordinary life or marriage.

Genetics Home Reference: Timothy syndrome

Science.gov (United States)

... 15 [updated 2015 Jul 16]. In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Ledbetter N, Mefford HC, Smith RJH, Stephens K, editors. GeneReviews® [Internet]. Seattle (WA): ...

Adaptation of Physiological and Cognitive Workload via Interactive Multi-modal Displays

Science.gov (United States)

2014-05-28

peer-reviewed journals (N/A for none) 09/07/2013 Received Paper 8.00 James Merlo, Joseph E. Mercado , Jan B.F. Van Erp, Peter A. Hancock. Improving...08, . : , Mr. Joseph Mercado , Mr. Timothy White, Dr. Peter Hancock. Effects of Cross-Modal Sensory Cueing Automation Failurein a Target Detection Task...fields:...... ...... ...... ...... ...... PERCENT_SUPPORTEDNAME FTE Equivalent: Total Number: Discipline Joseph Mercado 0.50 Timothy White 0.50 1.00 2

Governmental Control on Jurnalistic Practice in 'Pseudo-democratic' Malaysia and Singapore or Big Company Control on Journalistic Practice in 'Established-democratic' Australia: Which is Worse and Where Are the Parallesl

OpenAIRE

Sinclair, Elizabeth

2015-01-01

Amanda Whiting and Timothy Marjoribanks argued in their chapter Media professional’s perceptions of defamation and other constraints upon news reporting in Malaysia and Singapore[1]that Malaysia and Singapore experience, due to a number of factors, restricted media freedom - many of these factors relating to the semi-democratic nature of Malaysian and Singaporean government. [1]Amanda Whiting and Timothy Marjoribanks, ‘Media Professionals' Perceptions of Defamation and other Constraints u...

Rapid Translation of a Novel and Potent Vaccine in HER2+ Metastatic Breast Cancer Patients

Science.gov (United States)

2013-10-01

Xia3, Neil Spector2,3, Larry S Barak4, Timothy M Clay5, Takuya Osada2, Erika Hamilton6, Kimberly Blackwell6, Amy C Hobeika2, Michael A Morse2,3, H Kim...Zhang L, Boehm MF, Fritz LC, Burrows FJ: A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 2003, 425:407...410. 13. Zhang H, Burrows F: Targeting multiple signal transduction pathways through inhibition of Hsp90. J Mol Med (Berl) 2004, 82:488-499. 14. Basso

A Tale of One China: How and Why Has the Efficacy of United States Arms Sales to Taiwan Changed Since 1990

Science.gov (United States)

2016-05-01

Col Timothy M. Cullen , Ph.D. Date ii DISCLAIMER The conclusions and opinions expressed in this document are those...thesis. I am also greatly indebted to Colonel Timothy Cullen , Ph.D., and Dr. Mark Conversino, for their guidance and mentorship, not only on this...http://articles.latimes.com/2001/apr/22/news/ mn-54114. 7 William Lowther, “Taiwan Still a Top Buyer of US Arms,” Taipei Times, 22 December 2011

Operations Events Census Report: Volume IV. 1981 through 1985. Sanitized Version.

Science.gov (United States)

1991-04-01

SMITH, BRADY F. 0837 SMITH, BRUCE E. 0638 SMITH, CHARLOTT W. 0837 SMITH, CLIFFORD H. 0869 SMITH, COLIN C. 0483 SMITH, DARWIN 0599 SMITH, DAVID L... COLIN A. 097! MOORE, EDDIE L. 06491 MOORE, GERALD J. 0738 MORACA, STEPHEN L. 0837 MORAN, KEVIN 0599 MORAN, MARY SHANKS 0861 MORAVEC, TIMOTHY 0599...DRIESBACH, ROBERT A. 0599 DROTLEFF, JAMES E. 0746 DRUMMOND, VEE DEE 0636 DRURY , TIMOTHY E. 0920 DUANE, DENNIS 0636 DUBARTON, ANNE EVELYN 0918 DUENAS

Timothy Garton Ash: Euroopas ei tohi olla "mälupoliitikaid" / Timothy Garton Ash ; intervjueerinud Andrei Hvostov

Index Scriptorium Estoniae

Garton Ash, Timothy, 1955-

2009-01-01

Briti ajaloolane, politoloog ja kolumnist vastab küsimustele, mis puudutavad ajaloo ümberkirjutamist, EL-i välispoliitika kujundamist, Saksamaa katset anda väikeste lastega vanematele hääletamisel lisajõudu, samuti kapitalismi ja sotsialismi, natsismi ja kommunismi

Pembrolizumab in the treatment of metastatic non-small-cell lung cancer: patient selection and perspectives

Directory of Open Access Journals (Sweden)

Somasundaram A

2017-01-01

Full Text Available Ashwin Somasundaram, Timothy F Burns Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA Abstract: Lung cancer is the leading killer of both men and women in the US, and the 5-year survival remains poor. However, the approval of checkpoint blockade immunotherapy has shifted the treatment paradigm and provides hope for improved survival. The ability of non-small-cell lung cancer (NSCLC to evade the host immune system can be overcome by agents such as pembrolizumab (MK-3475/lambrolizumab, which is a monoclonal antibody targeting the programmed death 1 (PD-1 receptor. In early studies, treatment with pembrolizumab led to dramatic and durable responses in select patients (PD-L1+ tumors. This remarkable efficacy lead to approval of pembrolizumab in the second-line setting as response rates were almost doubled compared to standard of care (SOC chemotherapy. Most recently, data in the first-line setting from the KEYNOTE-024 study have redefined the SOC therapy for a selected subset of patients. In patients with ≥50% PD-L1+ tumors, pembrolizumab had a clear progression-free survival and overall survival benefit. Toxicity was mostly immune related and similar to checkpoint blockade toxicities observed in previous studies. The initial approval and subsequent studies of pembrolizumab required and utilized a companion diagnostic test, Dako’s IHC 22C3, to assess PD-L1 status of patients. The evaluation and scoring system of this assay has been used by other companies as a reference to develop their own assays, which may complicate selection of patients. Finally, the impact of pembrolizumab in NSCLC is growing as evidenced by the numerous, ongoing trials open for combinations with chemotherapy, chemoradiation, other immunotherapeutics, immunomodulators, tyrosine kinase inhibitors, PI3K inhibitors, MEK inhibitors, hypomethylating agents, and histone deacetylase inhibitors. Further studies

Methane production, nutrient digestion, ruminal fermentation, N balance, and milk production of cows fed timothy silage- or alfalfa silage-based diets.

Science.gov (United States)

Hassanat, F; Gervais, R; Massé, D I; Petit, H V; Benchaar, C

2014-10-01

The objective of this study was to investigate the effects of changing forage source in dairy cow diets from timothy silage (TS) to alfalfa silage (AS) on enteric CH₄ emissions, ruminal fermentation characteristics, digestion, milk production, and N balance. Nine ruminally cannulated lactating cows were used in a replicated 3 × 3 Latin square design (32-d period) and fed (ad libitum) a total mixed ration (TMR; forage:concentrate ratio of 60:40, dry matter basis), with the forage portion consisting of either TS (0% AS; 0% AS and 54.4% TS in the TMR), a 50:50 mixture of both silages (50% AS; 27.2% AS and 27.2% TS in the TMR), or AS (100% AS; 54.4% AS and 0% TS in the TMR). Compared with TS, AS contained less (36.9 vs. 52.1%) neutral detergent fiber but more (20.5 vs. 13.6%) crude protein (CP). In sacco 24-h ruminal degradability of organic matter (OM) was higher for AS than for TS (73.5 vs. 66.9%). Replacement of TS with AS in the diet entailed increasing proportions of corn grain and bypass protein supplement at the expense of soybean meal. As the dietary proportion of AS increased, CP and starch concentrations increased, whereas fiber content declined in the TMR. Dry matter intake increased linearly with increasing AS proportions in the diet. Apparent total-tract digestibility of OM and gross energy remained unaffected, whereas CP digestibility increased linearly and that of fiber decreased linearly with increasing inclusion of AS in the diet. The acetate-to-propionate ratio was not affected, whereas ruminal concentration of ammonia (NH₃) and molar proportion of branched-chain VFA increased as the proportion of AS in the diet increased. Daily CH₄ emissions tended to increase (476, 483, and 491 g/d for cows fed 0% AS, 50% AS, and 100% AS, respectively) linearly as cows were fed increasing proportions of AS. Methane production adjusted for dry matter intake (average=19.8 g/kg) or gross energy intake (average=5.83%) was not affected by increasing AS inclusion

AM2 Modified 2-1 Lay Pattern Evaluation under F-15E Traffic

Science.gov (United States)

2015-08-01

te ch ni ca l a nd S tr uc tu re s La bo ra to ry Lyan Garcia, Julie Heiser , Timothy W. Rushing, Chase T. Bradley, Jeb S. Tingle, and Craig...Engineer Research and Development Center 3909 Halls Ferry Road Vicksburg, MS 39180-6199 Julie Heiser Applied Research Associates 430 West 5th Street...5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Lyan Garcia, Julie Heiser , Timothy W. Rushing, Chase T. Bradley, Jeb S. Tingle, and Craig A

NATO - Standardization of Equipment Now and in the Future.

Science.gov (United States)

1986-05-14

RD-RI66 472 NATO - STANDRROIZRTION OF EGUI UET MOM AMO IN THE 1/1 FUTUREMU RY MAR COLL CARLISLE SARACKS PA T C SCOBIE 14 NAY SE UNCLASSIFIEP F/O 15/5...FUTURE BY COLONEL TIMOTHY C. SCOBIE D T IC IIELECTE JUN 17 LD DISTRIBUTION STATEMENT A: Approved for public release- distribution is unlimited. Aq14...AUTHOR(*) S. CONTRACT OR GRANT NUMBER(&) COL Timothy C. Scobie 9. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT. TASK AREA d WORK

Hyposensitization therapy with whole pollen extract or purified allergens monitored by immunoblotting

DEFF Research Database (Denmark)

Jarolim, E; Matthiesen, F; Skov, P S

1990-01-01

. Inhibition experiments using allergenic components isolated by preparative sodium dodecyl sulphate-polyacrylamide gel electrophoresis indicated that all antigenic components of timothy grass pollen detected in immunoblot dispose of private and cross-reactive determinants for binding of human IgE. The worse......Patients allergic to grass pollen were hyposensitized with two major allergenic components or whole extract of timothy grass pollen. Specific IgE, IgG1, and IgG4 formed during immunotherapy were analyzed by immunoblotting. Similar antibody-binding patterns were observed in both patient groups...

The Moses Mabhida Medical Plan: medical care planning and execution at a FIFA2010 stadium; the Durban experience

OpenAIRE

Timothy C Hardcastle; Mergan Naidoo; Sanjay Samlal; et al

2010-01-01

Timothy C Hardcastle1,2, Mergan Naidoo3,4, Sanjay Samlal5,6, Morgambery Naidoo5,6, Timothy Larsen5,6, Muzi Mabasu5,6,7, Sibongiseni Ngema6,81Inkosi Albert Luthuli Hospital, Mayville, South Africa; 2Department of Surgery, University of KwaZulu-Natal, Durban, South Africa; 3Wentworth Hospital, Durban, South Africa; 4Department of Family Medicine, University of KwaZulu-Natal, Durban, South Africa; 5Emergency Medical Rescue Service, KwaZulu-Natal, South Africa; 6Department of Health, KwaZulu-Nata...

Invited Commentary: Can Issues With Reproducibility in Science Be Blamed on Hypothesis Testing?

Science.gov (United States)

Weinberg, Clarice R.

2017-01-01

Abstract In the accompanying article (Am J Epidemiol. 2017;186(6):646–647), Dr. Timothy Lash makes a forceful case that the problems with reproducibility in science stem from our “culture” of null hypothesis significance testing. He notes that when attention is selectively given to statistically significant findings, the estimated effects will be systematically biased away from the null. Here I revisit the recent history of genetic epidemiology and argue for retaining statistical testing as an important part of the tool kit. Particularly when many factors are considered in an agnostic way, in what Lash calls “innovative” research, investigators need a selection strategy to identify which findings are most likely to be genuine, and hence worthy of further study. PMID:28938713

Fatty acid composition of forage herb species

DEFF Research Database (Denmark)

Warner, D.; Jensen, Søren Krogh; Cone, J.W.

2010-01-01

The use of alternative forage species in grasslands for intensive livestock production is receiving renewed attention. Data on fatty acid composition of herbs are scarce, so four herbs (Plantago lanceolata, Achillea millefolium, Cichorium intybus, Pastinaca sativa) and one grass species (timothy......, Phleum pratense) were sown in a cutting trial. The chemical composition and concentration of fatty acids (FA) of individual species were determined during the growing season. Concentrations of crude protein and FA were generally higher in the herbs than in timothy. C. intybus had the highest nutritive...

Implementation of an Agent-Based Parallel Tissue Modelling Framework for the Intel MIC Architecture

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Maciej Cytowski

2017-01-01

Full Text Available Timothy is a novel large scale modelling framework that allows simulating of biological processes involving different cellular colonies growing and interacting with variable environment. Timothy was designed for execution on massively parallel High Performance Computing (HPC systems. The high parallel scalability of the implementation allows for simulations of up to 109 individual cells (i.e., simulations at tissue spatial scales of up to 1 cm3 in size. With the recent advancements of the Timothy model, it has become critical to ensure appropriate performance level on emerging HPC architectures. For instance, the introduction of blood vessels supplying nutrients to the tissue is a very important step towards realistic simulations of complex biological processes, but it greatly increased the computational complexity of the model. In this paper, we describe the process of modernization of the application in order to achieve high computational performance on HPC hybrid systems based on modern Intel® MIC architecture. Experimental results on the Intel Xeon Phi™ coprocessor x100 and the Intel Xeon Phi processor x200 are presented.

GOVERNMENTAL CONTROL ON JURNALISTIC PRACTICE IN 'PSEUDO-DEMOCRATIC' MALAYSIA AND SINGAPORE OR BIG COMPANY CONTROL ON JOURNALISTIC PRACTICE IN 'ESTABLISHED-DEMOCRATIC' AUSTRALIA: WHICH IS WORSE AND WHERE ARE THE PARALLESL

Directory of Open Access Journals (Sweden)

Elizabeth Sinclair

2015-04-01

Full Text Available Amanda Whiting and Timothy Marjoribanks argued in their chapter Media professional’s perceptions of defamation and other constraints upon news reporting in Malaysia and Singapore[1]that Malaysia and Singapore experience, due to a number of factors, restricted media freedom - many of these factors relating to the semi-democratic nature of Malaysian and Singaporean government. [1]Amanda Whiting and Timothy Marjoribanks, ‘Media Professionals' Perceptions of Defamation and other Constraints upon News Reporting in Malaysia and Singapore’ in Andrew Kenyon, Tim Marjoribanks, Amanda Whiting (eds. Democracy, Media and Law in Malaysia and Singapore (Routledge, London, 2013, 129-156.

Uses of thaxtomin and thaxtomin compositions as herbicides

Energy Technology Data Exchange (ETDEWEB)

Koivunen, Marja; Marrone, Pamela

2016-12-27

There is a need for a selective, low-risk herbicide that can be used to control weeds in cereal cultures and turf. The present invention discloses that a bacterial secondary metabolite, thaxtomin and optionally another herbicide is an effective herbicide on broadleaved, sedge and grass weeds. Thaxtomin A and structurally similar compounds can be used as natural herbicides to control the germination and growth of weeds in cereal, turf grass, Timothy grass and pasture grass cultures with no phytotoxicity to these crops. As a natural, non-toxic compound, thaxtomin can be used as a safe alternative for weed control in both conventional and organic farming and gardening systems.

Dual Optical Recordings for Action Potentials and Calcium Handling in Induced Pluripotent Stem Cell Models of Cardiac Arrhythmias Using Genetically Encoded Fluorescent Indicators

Science.gov (United States)

Song, LouJin; Awari, Daniel W.; Han, Elizabeth Y.; Uche-Anya, Eugenia; Park, Seon-Hye E.; Yabe, Yoko A.; Chung, Wendy K.

2015-01-01

Reprogramming of human somatic cells to pluripotency has been used to investigate disease mechanisms and to identify potential therapeutics. However, the methods used for reprogramming, in vitro differentiation, and phenotyping are still complicated, expensive, and time-consuming. To address the limitations, we first optimized a protocol for reprogramming of human fibroblasts and keratinocytes into pluripotency using single lipofection and the episomal vectors in a 24-well plate format. This method allowed us to generate multiple lines of integration-free and feeder-free induced pluripotent stem cells (iPSCs) from seven patients with cardiac diseases and three controls. Second, we differentiated human iPSCs derived from patients with Timothy syndrome into cardiomyocytes using a monolayer differentiation method. We found that Timothy syndrome cardiomyocytes showed slower, irregular contractions and abnormal calcium handling compared with the controls. The results are consistent with previous reports using a retroviral method for reprogramming and an embryoid body-based method for cardiac differentiation. Third, we developed an efficient approach for recording the action potentials and calcium transients simultaneously in control and patient cardiomyocytes using genetically encoded fluorescent indicators, ArcLight and R-GECO1. The dual optical recordings enabled us to observe prolonged action potentials and abnormal calcium handling in Timothy syndrome cardiomyocytes. We confirmed that roscovitine rescued the phenotypes in Timothy syndrome cardiomyocytes and that these findings were consistent with previous studies using conventional electrophysiological recordings and calcium imaging with dyes. The approaches using our optimized methods and dual optical recordings will improve iPSC applicability for disease modeling to investigate mechanisms underlying cardiac arrhythmias and to test potential therapeutics. PMID:25769651

Kesk-Euroopa mõistatus / Timothy Garton Ash

Index Scriptorium Estoniae

Garton Ash, Timothy, 1955-

1999-01-01

Termini Kesk-Euroopa tekkeloost ja erinevatest tõlgendustest. Slovakkia lähiajaloost. Kaart: Lääne tsivilisatsiooni idapiir Samuel Huntingtoni raamatust "The Clash of Civilizations and the Remarking of World Order"

Euroopa tõelised lood / Timothy Garton Ash

Index Scriptorium Estoniae

Garton Ash, Timothy, 1955-

2007-01-01

Autor arutleb uue Euroopa identiteedi loomise võimalusi kuue väärtuse - vabaduse, rahu, seaduste, jõukuse, mitmekesisuse ja solidaarsuse abil. Vt. samas Nigel Haywood: uued liikmesriigid - rohkem muresid või kogemusi?; Marianne Mikko: Kas Euroopa Liidu laienemisele tuleb piir ette?

UNDERSTANDING SEVERE WEATHER PROCESSES THROUGH SPATIOTEMPORAL RELATIONAL RANDOM FORESTS

Data.gov (United States)

National Aeronautics and Space Administration — UNDERSTANDING SEVERE WEATHER PROCESSES THROUGH SPATIOTEMPORAL RELATIONAL RANDOM FORESTS AMY MCGOVERN, TIMOTHY SUPINIE, DAVID JOHN GAGNE II, NATHANIEL TROUTMAN,...

Phleum pratense pollen starch granules induce humoral and cell-mediated immune responses in a rat model of allergy.

Science.gov (United States)

Motta, A; Peltre, G; Dormans, J A M A; Withagen, C E T; Lacroix, G; Bois, F; Steerenberg, P A

2004-02-01

Timothy grass (Phleum pratense) pollen allergens are an important cause of allergic symptoms. However, pollen grains are too large to penetrate the deeper airways. Grass pollen is known to release allergen-bearing starch granules (SG) upon contact with water. These granules can create an inhalable allergenic aerosol capable of triggering an early asthmatic response and are implicated in thunderstorm-associated asthma. We studied the humoral (IgE) and bronchial lymph node cells reactivities to SG from timothy grass pollen in pollen-sensitized rats. Brown-Norway rats were sensitized (day 0) and challenged (day 21) intratracheally with intact pollen and kept immunized by pollen intranasal instillation by 4 weeks intervals during 3 months. Blood and bronchial lymph nodes were collected 7 days after the last intranasal challenge. SG were purified from fresh timothy grass pollen using 5 microm mesh filters. To determine the humoral response (IgE) to SG, we developed an original ELISA inhibition test, based on competition between pollen allergens and purified SG. The cell-mediated response to SG in the bronchial lymph node cells was determined by measuring the uptake of [3H]thymidine in a proliferation assay. An antibody response to SG was induced, and purified SG were able to inhibit the IgE ELISA absorbance by 45%. Pollen extract and intact pollen gave inhibitions of 55% and 52%, respectively. A cell-mediated response was also found, as pollen extract, intact pollen and SG triggered proliferation of bronchial lymph node cells. It was confirmed that timothy grass pollen contains allergen-loaded SG, which are released upon contact with water. These granules were shown to be recognized by pollen-sensitized rats sera and to trigger lymph node cell proliferation in these rats. These data provide new arguments supporting the implication of grass pollen SG in allergic asthma.

Kidney injury molecule-1 and microalbuminuria levels in Zambian ...

African Journals Online (AJOL)

Kidney injury molecule-1 and microalbuminuria levels in Zambian population: biomarkers of kidney injury. Mildred Zulu, Trevor Kaile, Timothy Kantenga, Chisanga Chileshe, Panji Nkhoma, Musalula Sinkala ...

Uurimist toimetavad Wolfe ja Goodwin / Katrin Mõttus

Index Scriptorium Estoniae

Mõttus, Katrin

2003-01-01

Sari filme - Rex Stout'i detektiivromaanide ekraniseeringud, kus peategelaseks eradetektiiv Nero Wolfe (Maury Chaykin) koos oma noore abilise Archie Goodwiniga (Timothy Hutton) : Ameerika Ühendriigid 2001-2002

Viie distsipliini rakendamise käsiraamat loob tervikpildi / Toomas Kink

Index Scriptorium Estoniae

Kink, Toomas

2009-01-01

Õppivaks organisatsiooniks saab kujuneda ainult meeskondliku ühistegevuse kaudu. Tutvustatakse raamatut: Õppiv kool / Peter Senge, Nelda Cambron-McCabe, Timothy Lucas ... [jt.]. Tartu : Atlex, 2009

Mõrvade üleeuroopaline dimensioon / Karsten Brüggemann ; saksa keelest tõlkinud Tea Vassiljeva

Index Scriptorium Estoniae

Brüggemann, Karsten, 1965-

2011-01-01

Arvustus: Naimark, Norman M. Stalin's genocides. Princeton (N.J.) ; Oxford : Princeton University Press, 2010 ; Snyder, Timothy. Bloodlands : Europe between Hitler and Stalin. New York : Basic Books, c2010

RECORD CLUB

CERN Multimedia

Record Club

2010-01-01

DVD James Bond – Series Complete To all Record Club Members, to start the new year, we have taken advantage of a special offer to add copies of all the James Bond movies to date, from the very first - Dr. No - to the latest - Quantum of Solace. No matter which of the successive 007s you prefer (Sean Connery, George Lazenby, Roger Moore, Timothy Dalton, Pierce Brosnan or Daniel Craig), they are all there. Or perhaps you have a favourite Bond Girl, or even perhaps a favourite villain. Take your pick. You can find the full selection listed on the club web site http://cern.ch/crc; use the panel on the left of the page “Discs of the Month” and select Jan 2010. We remind you that we are open on Mondays, Wednesdays and Fridays from 12:30 to 13:00 in Restaurant 2 (Bldg 504).

Taxonomic and phylogenetic utility of variation in advertising calls of ...

African Journals Online (AJOL)

Taxonomic and phylogenetic utility of variation in advertising calls of francolins and spurfowls (Galliformes: Phasianidae). Tshifhiwa G. Mandiwana-Neudani, Rauri C.K. Bowie, Martine Hausberger, Laurence Henry, Timothy M. Crowe ...

Defense AT&L (Volume 36, Number 1, January-February 2007)

National Research Council Canada - National Science Library

2007-01-01

...: I," -- by Timothy S. Kroecker -- Organizations must accept that individuals receive technical training for high-responsibility program management positions but may lack the depth of experience or leadership required for effectiveness...

Bilateral ovarian serous cystadenocarcinoma in a teenager

African Journals Online (AJOL)

abp

2017-09-12

Sep 12, 2017 ... &Corresponding author: Timothy Abiola Oluwasola, Department of Obstetrics and Gynaecology, ... in women accounting for 151,900 deaths in 2012 [1]. .... presentation in UCH which would have positively contributed to her.

Cellular computing

National Research Council Canada - National Science Library

Amos, Martyn

2004-01-01

... 120 Ron Weiss, Thomas F. Knight Jr., and Gerald Sussman 8 The Biology of Integration of Cells into Microscale and Nanoscale Systems 148 Michael L. Simpson, Timothy E. McKnight, Michael A. Guillor...

76 FR 7625 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

Science.gov (United States)

2011-02-10

... exempts, Thomas H. Adams, Jr., Charlie A. Barner, Charles G. Beasley, Philp M. Carr, Timothy D. Cochran..., Darwin D. Roberts, Robert A. Roskamp, David N. Studebaker, Danny J. Watson, Robert L. Wenzel, David A...

Padvinders, Pandu, Pramuka: Youth and State in the 20th Century ...

African Journals Online (AJOL)

seriane.camara

2011-12-01

Dec 1, 2011 ... learn and develop good character, trustworthiness, discipline, intelligence, ...... the Muhammadiyah seized it as an opportunity to re-activate Hizbul Wathan .... Parsons, Timothy H., 2001, 'No More English than the Postal ...

Acute Pancreatitis and Pregnancy

Science.gov (United States)

... Pancreatitis Acute Pancreatitis and Pregnancy Acute Pancreatitis and Pregnancy Timothy Gardner, MD Acute pancreatitis is defined as ... pancreatitis in pregnancy. Reasons for Acute Pancreatitis and Pregnancy While acute pancreatitis is responsible for almost 1 ...

PÖFFil ärkab ellu ooperifantoom / Immo Mihkelson

Index Scriptorium Estoniae

Mihkelson, Immo, 1959-

2004-01-01

Tallinna VIII Pimedate Ööde Filmifestivali avalöögiks on kontsertlinastus USA 1925.a. õudusfilmist "Ooperifantoom", mida saadab Carl Davise muusika Vanemuise Sümfooniaorkestri esituses Timothy Redmondi juhatusel. Lisatud "Fakte PÖFFist"

Vernalization response of Phleum pratense and its relationships to stem lignification and floral transition

DEFF Research Database (Denmark)

Seppänen, Mervi M; Pakarinen, Kirsi; Jokela, Venla

2010-01-01

Background Timothy is a long-day grass species well adapted for cultivation in northern latitudes. It produces elongating tillers not only in spring growth but also later in summer. As the quantity and quality of harvested biomass is dictated by canopy architecture and the proportion of stem......-forming flowering tillers, the regulation of flowering is of great interest in forage grass production. Methods Canopy architecture, stem morphology and freezing tolerance of vernalized timothy were investigated in greenhouse and field experiments. The molecular control of development was examined by analysing......, however, divergent morphology. Vernalization enhanced flowering, and the expression of the VRN1 homologue was elevated when the apex had passed into the reproductive stage. High VRN1 homologue expression was not associated with reduction in freezing tolerance and the expression coincided with increased...

Invited Commentary: Can Issues With Reproducibility in Science Be Blamed on Hypothesis Testing?

Science.gov (United States)

Weinberg, Clarice R

2017-09-15

In the accompanying article (Am J Epidemiol. 2017;186(6):646-647), Dr. Timothy Lash makes a forceful case that the problems with reproducibility in science stem from our "culture" of null hypothesis significance testing. He notes that when attention is selectively given to statistically significant findings, the estimated effects will be systematically biased away from the null. Here I revisit the recent history of genetic epidemiology and argue for retaining statistical testing as an important part of the tool kit. Particularly when many factors are considered in an agnostic way, in what Lash calls "innovative" research, investigators need a selection strategy to identify which findings are most likely to be genuine, and hence worthy of further study. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Autoantibodies

Science.gov (United States)

... Antibodies Beta-2 Glycoprotein 1 Antibodies Antiphospholipid Antibodies (APA) Lupus anticoagulants (LA) Endocrine/metabolic system Diabetes-related ... Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO. What ...

Love, lust and the emotional context of multiple and concurrent ...

African Journals Online (AJOL)

Love, lust and the emotional context of multiple and concurrent sexual partnerships among young Swazi adults. Allison Ruark, Lunga Dlamini, Nonhlanhla Mazibuko, Edward C Green, Caitlin Kennedy, Amy Nunn, Timothy Flanigan, Pamela J Surkan ...

77 FR 74273 - Qualification of Drivers; Exemption Applications; Vision

Science.gov (United States)

2012-12-13

... (SD) Terry L. Anderson (PA) Sammy J. Barada (NE) Timothy Bradford (TN) Cody W. Cook (OK) Marvin R...) Thomas L. Oglesby (GA) Garrick Pitts (AR) Jonathan C. Rollings (IA) Preston S. Salisbury (MT) Victor M...

Meie "oma" Unabomber - kes ta on? / Valdek Kiiver

Index Scriptorium Estoniae

Kiiver, Valdek

2005-01-01

1995. a. tabasid USA võimud riiki 17 aastat kirjapommidega terroriseerinud kurjategija, keda kutsuti Unabomberiks. Theodore Kaczynsky (Unabomberi) tegevusest ja tabamisest. Vt. samas: Oklahoma, 1995. Timothy McVeigh kui Oklahoma föderaalkohtuhoones plahvatuse organiseerija

Chemotherapy Side Effects: A Cause of Heart Disease?

Science.gov (United States)

... Can chemotherapy side effects increase the risk of heart disease? Answers from Timothy J. Moynihan, M.D. Chemotherapy side effects may increase the risk of heart disease, including weakening of the heart muscle (cardiomyopathy) and ...

Festival lähetab maailma eri nurkadesse / Kerttu Jänese

Index Scriptorium Estoniae

Jänese, Kerttu, 1946-

2008-01-01

V dokumentaal- ja antropoloogiliste filmide festival "Maailmafilm" algab 24. märtsil Eesti Rahva Muuseumi näitusemajas Tartus. Kavas on ka kolm eriprogrammi: kirjanikud filmis, klassiku Timothy Aschi looming ja 8 filmi inimesest linnas

Blood Typing

Science.gov (United States)

... article The Universe of Genetic Testing: The Basics , Identity Testing , and Parentage Testing . What does the test ... Pagana, Kathleen D. & Pagana, Timothy J. (© 2006). Mosby's Manual of Diagnostic and Laboratory Test 3rd Edition: Mosby, ...

Cancer Prevention in the Precision Medicine Era | Division of Cancer Prevention

Science.gov (United States)

Speaker | Timothy R. Rebbeck, PhD will present "Cancer Prevention in the Precision Medicine Era" on March 20, 2018, from 11:00 am - 12:00 pm at the NCI Shady Grove Campus. Learn more about this lecture.

Kodanike või riikide Euroopa? / Julia Laffranque

Index Scriptorium Estoniae

Laffranque, Julia, 1974-

2005-01-01

Demokraatiast, Euroopa põhiseaduse lepingust ja Euroopa Liidu tulevikust. Lisatud: samal teemal: Briti ajaloolane Timothy Garton Ash: mure immigrantide pärast tõi kriisi ; Prantsuse filosoof Paul Virillo: rahvahääletus ise oli suurim viga

Avaliação da bupivacaína hipobárica a 0,5% na raquianestesia Evaluación de la bupivacaína hipobárica a 0,5% en la anestesia espinal Evaluation of 0.5% hypobaric bupivacaine in spinal anesthesia

Directory of Open Access Journals (Sweden)

Marcelo Cursino Pinto dos Santos

2007-08-01

Full Text Available JUSTIFICATIVA E OBJETIVOS: A raquianestesia causa alterações hemodinâmicas relacionadas com fatores próprios do paciente ou não. Um dos fatores é a densidade do anestésico em relação ao líquor, interferindo no número de dermátomos bloqueados e, conseqüentemente, no nível do bloqueio simpático e na diminuição da pressão arterial (PA. O objetivo do estudo foi avaliar a dispersão da bupivacaína hipobárica a 0,5%, preparada assepticamente em laboratório e com uma densidade controlada e uniforme. MÉTODO: Trinta pacientes, ASA I, II ou III, com idade entre 18 e 60 anos, sem comorbidades circulatórias, submetidos a operações ortopédicas no membro inferior participaram do estudo. Eles foram sedados com diazepam 0,03 mg.kg-1, posicionados em decúbito lateral com o lado a ser operado para cima, e puncionados entre L3-L4, com agulha de Quincke 27G, sendo padronizados o direcionamento do bisel e a velocidade de injeção. Foram avaliados os níveis sensitivos e motor (escala modificada de Bromage. RESULTADOS: Ao fim da operação, dois pacientes (6,6% não apresentaram bloqueio motor classificado como 3 na escala de Bromage, com o bloqueio sensitivo variando entre T4 e T12. Somente 12,9% dos pacientes apresentaram nível sensitivo considerado "alto" para a operação proposta (acima de T6. A diminuição da pressão arterial foi significativa sob o ponto de vista estatístico, sem atingir 20% abaixo dos valores basais, portanto, sem significância clínica. A variação da freqüência cardíaca não foi significativa. CONCLUSÕES: A bupivacaína hipobárica a 0,5% mostrou ser uma opção segura e com poucas repercussões hemodinâmicas para operações ortopédicas nos membros inferiores. A duração média observada, de 250 minutos, possibilita a realização de procedimentos ortopédicos de até médio porte.JUSTIFICATIVA Y OBJETIVOS: La anestesia espinal causa alteraciones hemodinámicas relacionadas a factores propios del

T3 (Triiodothyronine) Test

Science.gov (United States)

... Reviews Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition]. Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and ... Medical Encyclopedia [On-line information]. Available online at http:// ...

Comparison of ropivacaine and bupivacaine as single-shot epidural anaesthesia for orthopaedic surgery

International Nuclear Information System (INIS)

Riaz, A.; Khan, A.S.

2015-01-01

To compare the efficacy and side-effects of 0.5% ropivacaine with that of 0.5% bupivacaine when used for single-shot epidural anaesthesia for orthopaedic surgery. Design: Randomized controlled trial. Place and Duration of Study: Department of Anesthesiology, Combined Military Hospital Rawalpindi, over a period of eight months from June 2013 to January 2014. Patients and Methods: The study was carried out in 60 ASA physical status I, II or III patients undergoing elective lower extremity orthopedic surgery. Two groups of 30 patients each received single-shot epidural anaesthesia either with ropivacaine 0.5% (ropivacaine group) or bupivacaine 0.5% (bupivacaine group). Onset, time for maximum height and median height of sensory block was assessed as well as time to two segment recession. Modified Bromage scale was used for motor blockade. Total duration of motor block and common side effects were also recorded. Results: The patients in both groups were similar in age, height, weight, gender and ASA status. There was no significant difference in onset of sensory block and time for maximum height of sensory block. The median heighest level of sensory block was T6 (T5-T8) for ropivacaine group and T5 (T4-T7) for bupivacaine group. Time for two segment regression and duration of sensory block were also comparable for both groups. The total duration of motor block was significantly more in bupivacaine group (159 min vs 134.2 min, p< 0.001). Modified Bromage scale was also significantly higher in bupivacaine group (2.86 vs 1.96 min, p<0.001). Side effects like hypotension, bradycardia, nausea, vomiting and shivering were similar in both groups. Conclusion: Epidural administration of 0.5% ropivacaine provided effective and good quality anaesthesia. Motor blockade was of less duration as compared to equivalent dose of 0.5% bupivacaine, which may offer potential benefit of early patient mobilization after orthopaedic surgery. (author)

ACTH (Adrenocorticotropic Hormone) Test

Science.gov (United States)

... Reviews Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition]. Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory ... Medical Encyclopedia [On-line information]. Available online at http:// ...

Return to Resistance

International Development Research Centre (IDRC) Digital Library (Canada)

Book design by Timothy Rice .... Crop production has increased also, very considerably, but so have the crop losses due to parasites, in spite ...... The pesticide manufacturers often refer to their take-overs of plant breeding and seed production ...

Database Development for Ocean Impacts: Imaging, Outreach, and Rapid Response

Science.gov (United States)

2012-09-30

Timothy Stanton Woods Hole Oceanographic Institution Acoustics PUBLICATIONS 33 Refereed, Published Articles Supported through this award 2012...Laboratory for Translational Auditory Research, Journal of the American Academy of Audiology , vol.23, Issue 6, New York, p.422-437. [published

Obama kriisitiimi juhib tugev kolmik / Sirje Rank

Index Scriptorium Estoniae

Rank, Sirje, 1966-

2008-01-01

USA presidendiks valitud Barack Obama kuulutab ametlikult välja oma meeskonna liikmed. Tulevane rahandusminister Timothy Geithner ning Valge Maja koordinatsiooni nõukogu tulevane juht Lawrence Summers seisavad vastamisi finantskriisi ületamise ning finantssüsteemi stabiliseerimise ülesandega

What's in a frame?

DEFF Research Database (Denmark)

Holmgreen, Lise-Lotte

Metaphor Analysis. Houndmills: Palgrave. Coombs, Timothy W. 1995. Choosing the right words: The development of guidelines for the selection of the “appropriate” crisis-response strategies. Management Communication Quarterly 8 (4): 447-476. Fillmore, Charles. 1975. An alternative to checklist theories...... from excellent to appalling within a number of months without it being able to benefit from its history of impeccable business conduct as the crisis hit (cf. Coombs 1995). In answering this question, I will argue that organisations are not operating in a social vacuum, but need to consider......In the wake of the 2008 financial crisis, many large international banks received heavy criticism for their business conduct, which involved investments in dubious loans and business projects. For Denmark’s largest bank, Danske Bank, the situation was no different; it went from being considered...

The Effect Of Supraphysiologic Blood Pressure on Traumatic Brain Injury and Proximal Tissue Beds During Resuscitative Balloon Occlusion of the Aorta and Variable Aortic Control in a Porcine Model (Sus scrofa) of Polytrauma.

Science.gov (United States)

2017-04-27

Control In A Porcine Model (Sus Scrofa) Of Polytrauma . PRINCIPAL INVESTIGATOR (PI) / TRAINING COORDINATOR (TC): Lt Col Timothy Williams DEPARTMENT...Mandatory) The Effect of REBOA, Partial Aortic Occlusion and Aggressive Blood Transfusion on Traumatic Brain Injury in a Swine Polytrauma Model

Southern African Journal of Anaesthesia and Analgesia - Vol 23, No ...

African Journals Online (AJOL)

Robert Wise, Kim de Vasconcellos, David Skinner, Reitze Rodseth, Dean Gopalan, David Muckart, Zohra Banoo, Tashmin Bisseru, Steve Blakemore, Jenine de Meyer, Michael Faurie, Kom Govender, Timothy Hardcastle, Prakash Jeena, Nicky Kalafatis, Kroshlan Kistan, Theroshnie Kisten, Carolyn Lee, Colin Mitchell, ...

Gastrointestinal symptoms among swimmers following rain events at a beach impacted by urban runoff

Science.gov (United States)

Gastrointestinal symptoms among swimmers following rain events at a beach impacted by urban runoff Timothy J. Wade, Reagan R. Converse, Elizabeth A. Sams, Ann H. Williams, Edward Hudgens, Alfred P. Dufour Gastrointestinal symptoms among swimmers have been associated with fecal ...

Military Interventions in Sierra Leone: Lessons from a Failed State

National Research Council Canada - National Science Library

Woods, Larry J; Reese, Timothy R

2008-01-01

This study by Larry J. Woods and Colonel Timothy R. Reese analyzes the massive turmoil afflicting the nation of Sierra Leone, 1993-2002, and the efforts by a variety of outside forces to bring lasting stability to that small country...

IgE profiles of Bermuda grass pollen sensitised patients evaluated by Phleum pratense allergens Phl P 1, 2, 4, 5, 6 , 7, 11, 12.

Science.gov (United States)

Rossi, Renato E; Monasterolo, Giorgio; Prina, Paolo; Coco, Giuseppe; Operti, Daniela; Rossi, Lucilla

2008-06-01

Despite the difference in geographical dominance of certain grasses, a high degree of allergenic similarity or cross-reactivity between Bermuda grass pollen (BGP) and timothy grass pollen (TGP) has been previously demonstrated. The aim of the present study was to ascertain the sensitisation to TGP in 411 patients known for their reactivity to BGP extracts by analysing their reactivity to crude timothy pollen extract and timothy pollen purified allergens, establishing their specific IgE-profiles. Using the immunoenzymatic CAP method we evaluated IgE-specific antibodies for BGP- and TGP- extracts and the timothy recombinant (r) and natural (n) allergens rPhl p 1, rPhl p 2, nPhl p 4, rPhl p 5, rPhl p 6, rPhl p 7, rPhl p 11, and rPhl p 12. BGP-IgE positive patients (median = 8.0 kUA/l, 2.8-22.2 kUA/l 25th-75th percentile) simultaneously had IgE positive results for TGP (100% of subjects)(median = 48.9 kUA/l, 19.8- > 100 kUA/l 25th-75th percentile) and high prevalence of sensitization to 6/8 Phleum pratense allergens (Phl p 1, 2, 4, 5, 6, 11, markers of genuine sensitisation to TGP) other than profilin and calcium binding protein. More than 72% of BGP allergic patients were co-sensitised to rPhl p 1, rPhl p 2, nPhl p 4, rPhl p 5, rPhl p 6. A decrease of total and specific IgE with patients' age was observed. Our data show that all BGP-allergic patients simultaneously exhibit higher IgE antibody levels to recombinant and natural P. pratense allergens as well as to crude TGP extract. This suggests that when choosing an immunotherapeutic regimen for BGP-sensitised patients (after establishing their IgE profile via purified TGP-allergens), subcutaneous or sublingual TGP-extract vaccines in appropriate doses, in order to influence T epitope specificity, might be beneficial. Though extremely uncommon, in cases where a patient is exclusively BGP allergen-sensitised, BGP-extract therapy is the appropriate therapeutic response.

The Effect of Interface Treatment on Ceramic Performance and Modeling Dyneema Subjected to Ballistic Impact

Science.gov (United States)

2018-01-23

Mechanical Engineering Division January 26, 2018 Professor KT Ramesh JHU/HEMI Project Director Johns Hopkins University 3400 N. Charles...Sincerely, Timothy J. Holmquist Institute Engineer ...Director Record Copy B (Contracts) Engineering Dynamics Department The Effect of Interface Treatment on Ceramic Performance and

Brief psychotic disorder

Science.gov (United States)

... as the cause of the symptoms. Treatment By definition, psychotic symptoms go away on their own in ... severely disrupt your life and possibly lead to violence and suicide. ... by: Timothy Rogge, MD, Medical Director, Family Medical Psychiatry Center, Kirkland, WA. Also reviewed by ...

75 FR 9248 - Endangered and Threatened Wildlife and Plants; Permit Applications

Science.gov (United States)

2010-03-01

... Applications Permit Application Number: TE006012. Applicant: Steven Taylor, Center for Biodiversity, Illinois... State University, Springfield, Missouri. The applicant requests a permit renewal to take (capture and... Application Number: TE02560A. Applicant: Timothy C. Carter, Ball State University, Muncie, Indiana. The...

National Wetland Plant List Indicator Rating Definitions

Science.gov (United States)

2012-07-01

glaucus (blue rye grass), Eragrostis pilosa (Indian love grass), Oenothera biennis (king’s-cureall), Ostrya virginiana (eastern hop-hornbeam...profile with a low wa- ter-holding capacity. ERDC/CRREL TN-12-1 6 Prunus serotina (black cherry), Phleum pretense (common timothy), Sarcobatus

Turu festivali võitjad kujutavad Eestit imelise muinasjutumaana / Eva Toome

Index Scriptorium Estoniae

Toome, Eva

2001-01-01

I Turu animafestivali Tough Eye grand prix läks jagamisele. Selle said Igor Kovaljovi joonisfilm "Tema naine kana" : Nõukogude Liit 1990 ja kaksikvendade Stephen ja Timothy Quay "In Absentia" : Suurbritannia 2000. Auhinnasaajad vastavad paarile küsimusele festivali ja Eesti kohta

Induced pluripotent stem cell-derived neuron as a human model for testing environmentally induced developmental neurotoxicity

Science.gov (United States)

Induced pluripotent stem cell-derived neurons as a human model for testing environmentally induced developmental neurotoxicity Ingrid L. Druwe1, Timothy J. Shafer2, Kathleen Wallace2, Pablo Valdivia3 ,and William R. Mundy2. 1University of North Carolina, Curriculum in Toxicology...

78 FR 68019 - Performance Review Board Appointments

Science.gov (United States)

2013-11-13

..., Arlean; Leonard, Joe; Linden, Ralph A.; Lippold, David; Lowe, Christopher S.; Lowe, Stephen O.; Maddux..., Michael; Nelson, Leiann H.; Willis, Brandon C.; Witt, Timothy; Worth, Thomas W. Food, Nutrition and...; Primrose, Edna; Ross, Robert H.; Salguero, Francisco. Rural Utilities Service Ackerman, Kenneth; Adams...

APA/APAGS Award for Distinguished Graduate Student in Professional Psychology.

Science.gov (United States)

2016-11-01

The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. A qualified candidate must demonstrate exemplary performance in working with an underserved population in an applied setting or have developed an innovative method for delivering health services to an underserved population. The 2016 recipient of the APA/APAGS Award for Distinguished Graduate Student in Professional Psychology was selected by the 2015 Board of Professional Affairs (BPA) and the 2015 APAGS Scholarship and Awards Selection Committee. Members of the 2015 BPA were Patricia Arredondo, EdD; Helen L. Coons, PhD, ABPP; Vickie Mays, PhD, MSPH; Linda A. Reddy, PhD; Lois O. Condi, PhD; Antonette M. Zeiss, PhD; Timothy A. Cavell, PhD; Robert T. Kinscherff, PhD, JD; and Jared L. Skillings, PhD, ABPP. Members of the 2015 APAGS Scholarship and Awards Selection Committee were Emily Voelkel, PhD; Blaire Schembari; and Yolanda Perkins-Volk. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Fööniks Katõni tuhast / Timothy Garton Ash

Index Scriptorium Estoniae

Garton Ash, Timothy, 1955-

2010-01-01

Autor kirjeldab 1940. aastal NSV Liidu võimude poolt korraldatud Poola ohvitseride hukkamist ja edasist suurt valet, millega ühinesid ka lääneriigid. Võrdleb rahvusvahelise reaktsiooni kontrasti tollase veresauna ning 10. aprillil 2010. aastal Poola presidendi ja tema kaaskonna lennukiga toimunud katastroofi vahel

Ruling muddies path to election law reform / Timothy Jacobs

Index Scriptorium Estoniae

Jacobs, Timothy

2002-01-01

Euroopa Inimõiguste Kohtu lahendist, millega mõisteti välja hüvitis Ingrida Podkolzinale, kes ebapiisava riigikeele oskuse tõttu diskvalifitseeriti 1998. aasta Läti parlamendivalimiste kandidaadi kohalt

Scopus: Journal of East African Ornithology - Vol 36, No 2 (2016)

African Journals Online (AJOL)

Avifauna of Boni-Dodori National Reserves, Lamu and Garissa Counties, Kenya · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Tobias Otieno, Timothy Mwinami, Martha Ngala, Sandy Oduor, Fleur Ng'weno, Simon Musila, Charles Kimwele, 1-16 ...

Ikke en tid til mesterværker

DEFF Research Database (Denmark)

Thomsen, Torsten Bøgh

2014-01-01

Artiklen præsenterer en diskussion af den seneste miljøorienterede kulturteori indenfor retningen Spekulativ Realisme (Graham Harman, Timothy Morton) og sætter den i en historisk kontekst gennem romantisk filosofi og antikkens begreb om genius loci. Ydermere knyttes disse begreber specifikt til...

Installation Guidance for Centerline and Edgeline Rumble Strips in Narrow Pavements

Science.gov (United States)

2017-09-01

Peter T. Savolainen (orcid.org/0000-0001-5767-9104); Anuj Sharma (orcid.org/0000-0001-5929-5120); Timothy P. Barrette (orcid.org/0000-0002- 7656-3454); Bijan Vafaei (orcid.org/0000-0002-9362-399X); and Trevor J. Kirsch (orcid.org/0000-0002-8163-1570)...

Knowledge-Driven Design of Virtual Patient Simulations

Science.gov (United States)

Vergara, Victor; Caudell, Thomas; Goldsmith, Timothy; Panaiotis; Alverson, Dale

2009-01-01

Virtual worlds provide unique opportunities for instructors to promote, study, and evaluate student learning and comprehension. In this article, Victor Vergara, Thomas Caudell, Timothy Goldsmith, Panaiotis, and Dale Alverson explore the advantages of using virtual reality environments to create simulations for medical students. Virtual simulations…

Counter Piracy: A Repeated Game with Asymmetric Information

Science.gov (United States)

2009-09-01

Christopher D. Marsh Approved by: Kyle Y. Lin Thesis Advisor Timothy H. Chung Second Reader Robert F. Dell Chairman, Department of...encourage Malaysia and Indonesia to work with the Singapore Navy in coordinated patrols of the region. Increased cooperation in the region includes the

77 FR 1019 - Renewable Energy Alternate Uses of Existing Facilities on the Outer Continental Shelf-Acquire a...

Science.gov (United States)

2012-01-09

...-0045] RIN 1010-AD79 Renewable Energy Alternate Uses of Existing Facilities on the Outer Continental... rule related to acquiring a lease non-competitively for offshore renewable energy projects. DATES... or Timothy Redding, Renewable Energy, BOEM, at (703) 787-1219 or email [email protected

Air Force Command and Control: The Path Ahead. Volume 1: Summary

Science.gov (United States)

2000-12-01

Hughes Space and Communications Company Dr. Duane A. Adams Vice Provost for Research Carnegie Mellon University Mr. Timothy M. Bonds Analyst...ontology) and a set of callable service interfaces that are matched to the needs of various user communities. What’s needed, therefore, is a

Neokontshennaja pjessa dlja muzõkalnogo avtomata / Nikolai Karajev

Index Scriptorium Estoniae

Karajev, Nikolai, 1978-

2005-01-01

IX Pimedate Ööde Filmifestivali mängufilme - "Maavärinate klaverihäälestaja" (Piano Tuner of the Earthquakes") : režissöörid Stephen ja Timothy Quay : Suurbritannia - Saksamaa - Prantsusmaa 2005. Režissöörid tutvustasid oma filmi

Vendade Quayde film on nagu ballett / Merit Kask

Index Scriptorium Estoniae

Kask, Merit

2005-01-01

IX Pimedate Ööde Filmifestivali mängufilme - "Maavärinate klaverihäälestaja" (Piano Tuner of the Earthquakes") : režissöörid Stephen ja Timothy Quay : Suurbritannia - Saksamaa - Prantsusmaa 2005. Režissöörid tutvustasid oma filmi

Lauluga läbi Ameerika 4 / Helle Reinaru

Index Scriptorium Estoniae

Reinaru, Helle, 1955-

2006-01-01

EELK Misjonikoori kontsertturneest 5.-25. juulini Ameerika Ühendriikides ja Kanadas: jumalateenistusest 16. juulil Missoula St Paul'i luteri kirikus, kontserdist 17. juulil Calvary luteri kirikus, 18. juulil Seattle's Phinney Ridge kirikus, 20. juulil Kanada Scarborough St Timothy anglikaani kirikus ja 21. juulil Toronto baptistikirikus

Third International Conference on Complex Systems

CERN Document Server

Minai, Ali A; Unifying Themes in Complex Systems

2006-01-01

In recent years, scientists have applied the principles of complex systems science to increasingly diverse fields. The results have been nothing short of remarkable: their novel approaches have provided answers to long-standing questions in biology, ecology, physics, engineering, computer science, economics, psychology and sociology. The Third International Conference on Complex Systems attracted over 400 researchers from around the world. The conference aimed to encourage cross-fertilization between the many disciplines represented and to deepen our understanding of the properties common to all complex systems. This volume contains selected transcripts from presentations given at the conference. Speakers include: Chris Adami, Kenneth Arrow, Michel Baranger, Dan Braha, Timothy Buchman, Michael Caramanis, Kathleen Carley, Greg Chaitin, David Clark, Jack Cohen, Jim Collins, George Cowan, Clay Easterly, Steven Eppinger, Irving Epstein, Dan Frey, Ary Goldberger, Helen Harte, Leroy Hood, Don Ingber, Atlee Jackson,...

New Equipping Strategies for Combat Support Hospitals

Science.gov (United States)

2010-01-01

Combat and Doctrine Development and COL Timothy Lamb , supported by MAJ Gary Cooper, included members of our team in visits to Sierra Army Depot and...aspect of improving materiel stew - ardship is improving the quality of data related to the procurement, maintenance, and upgrading of equipment

78 FR 1265 - Sunshine Act; Notice of Meeting

Science.gov (United States)

2013-01-08

... South (both entry and exit). For those attending the La Jolla meeting, parking is expected to be..., 4340 East-West Highway, Room 700, Bethesda, Maryland 20814. The Commission already has met with...: Timothy J. Ragen, Executive Director, Marine Mammal Commission, 4340 East-West Highway, Room 700, Bethesda...

76 FR 71437 - Mutual Savings Association Advisory Committee

Science.gov (United States)

2011-11-17

... (MSAAC or Committee) formerly administered by the Office of Thrift Supervision, as it is necessary and in...: Timothy T. Ward, Deputy Comptroller for Thrift Supervision, 250 E Street SW., Washington, DC 20219. FOR... as federal savings associations (including federal savings banks); and (2) issue charters therefore...

Ostrich: Journal of African Ornithology - Vol 75, No 4 (2004)

African Journals Online (AJOL)

Fowl play: identification and management of hybridisation between wild and domestic Helmeted Guineafowl (Numida meleagris) in South Africa · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Andrew L Walker, Rauri CK Bowie, Charles S Ratcliffe, Timothy M Crowe, 195-198.

77 FR 68769 - Access to Confidential Business Information by Abt Associates, Inc.

Science.gov (United States)

2012-11-16

... industrial chemicals. Since other entities may also be interested, the Agency has not attempted to describe... information which has been submitted to EPA under section 8 of the Toxic Substances Control Act (TSCA). Some...: For technical information contact: Timothy Kiely, Office of Chemical Safety & Pollution Prevention...

A Modular Simulation Framework for Assessing Swarm Search Models

Science.gov (United States)

2014-09-01

SCHOOL September 2014 Author: Blake M. Wanier Approved by: Timothy H. Chung Thesis Advisor James Eagle Second Reader Robert Dell Chair, Department of...shipments of natural gas from Indonesia and Malaysia are redirected to China to support its growing domestic consumption, Japan’s discovery of large

African Journal of AIDS Research - Vol 13, No 2 (2014)

African Journals Online (AJOL)

Love, lust and the emotional context of multiple and concurrent sexual partnerships among young Swazi adults · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Allison Ruark, Lunga Dlamini, Nonhlanhla Mazibuko, Edward C Green, Caitlin Kennedy, Amy Nunn, Timothy Flanigan, ...

A long-term follow-up study of hyposensitization with immunoblotting

DEFF Research Database (Denmark)

Jarolim, E; Poulsen, L K; Stadler, B M

1990-01-01

The formation of specific IgE, IgG1, and IgG4 antibodies was investigated by immunoblotting during hyposensitization with timothy grass-pollen extract and 6 years later, Until the end of immunotherapy, specific IgG antibody levels increased. Also simultaneously, the number of allergenic component...

Phenotypic selection in natural populations: what limits directional selection?

Science.gov (United States)

Kingsolver, Joel G; Diamond, Sarah E

2011-03-01

Studies of phenotypic selection document directional selection in many natural populations. What factors reduce total directional selection and the cumulative evolutionary responses to selection? We combine two data sets for phenotypic selection, representing more than 4,600 distinct estimates of selection from 143 studies, to evaluate the potential roles of fitness trade-offs, indirect (correlated) selection, temporally varying selection, and stabilizing selection for reducing net directional selection and cumulative responses to selection. We detected little evidence that trade-offs among different fitness components reduced total directional selection in most study systems. Comparisons of selection gradients and selection differentials suggest that correlated selection frequently reduced total selection on size but not on other types of traits. The direction of selection on a trait often changes over time in many temporally replicated studies, but these fluctuations have limited impact in reducing cumulative directional selection in most study systems. Analyses of quadratic selection gradients indicated stabilizing selection on body size in at least some studies but provided little evidence that stabilizing selection is more common than disruptive selection for most traits or study systems. Our analyses provide little evidence that fitness trade-offs, correlated selection, or stabilizing selection strongly constrains the directional selection reported for most quantitative traits.

75 FR 70224 - New York Tidal Energy Company; Notice Concluding Pre-Filing Process and Approving Process Plan...

Science.gov (United States)

2010-11-17

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 12665-003] New York Tidal... Tidal Energy Company. e. Name of Project: East River Tidal Energy Pilot Project. f. Location: In the...-6405. i. FERC Contact: Timothy Konnert (202) 502-6359. j. New York Tidal Energy Company (NYTEC) has...

R-ES-ONANCE--INo-ve-mber

Indian Academy of Sciences (India)

Physiology or Medicine: has been jointly awarded to. Leland H Hartwell, Fred Hutchinson Cancer Research Center, University of Seattle, USA. R Timothy (Tim) Hunt, Clare Hall Laboratories, Cell Cycle Control Laboratory, UK. Paul M Nurse, Lincoln's Inn Fields Laboratories, Cell Cycle Laboratory, UK for their discoveries of ...

75 FR 49551 - Petition for Waiver of Compliance

Science.gov (United States)

2010-08-13

... below. Docket Number FRA-1998-4821 Applicant: Mr. Timothy R. Luhm, Canadian National, Manager S&C, 17641 South Ashland Avenue, Homewood, Illinois 60430. The Canadian National (CN) seeks an extension for an... expire on April 25, 2011. In addition to the extension, CN requests that the allowable maximum authorized...

Malaria Genome Sequencing Project

Science.gov (United States)

2004-01-01

UTTERBACK, TERESA RIGGS, FLORENCE VAN AKEN, SUSAN RIZZO, MICHAEL VISWANATHAN, LAKSHMI ROMERO , CALUDIA DEVI ROONEY, TIMOTHY VON ARX, ANNA RUCH, KAREN...Clark*, R. Clark*, C. Corton *, well with the predictions from the optical map. Chromosome 13 is A. Cronin*, R. Davies*, P. Davis*, P. Dear§, F. Dearden

Coalition Warfare Program Tactile Situation Awareness System for Aviation Applications: Simulator Flight Test

Science.gov (United States)

2015-12-01

David Myers1 Timothy Gowen2 Angus Rupert3 Ben Lawson3 Justin Dailey3,4 1Chesapeake Technology International 2Naval Aviation Center for... Angus Rupert of the USAARL. The algorithm is described in “Configuration Parameters for the Tactile Situation Awareness System (TSAS)” dated July 2010

Identification and Targeting of Tyrosine Kinase Activity in Prostate Cancer Initiation, Progression, and Metastasis

Science.gov (United States)

2013-12-01

University) "Effectors of the DNA damage and radiotherapy response in cancer" 9:20 pm - 9:30 pm Discussion TUESDAY 7:30 am - 8:30 am Breakfast 9:00...M. Morris , Hideki Onagi, Timothy M. Altamore, Allan B. Gamble, Christopher J. Easton Prohormone-substrate peptide sequence recognition by

CDApps: integrated software for experimental planning and data processing at beamline B23, Diamond Light Source. Corrigendum.

Science.gov (United States)

Hussain, Rohanah; Benning, Kristian; Myatt, Daniel; Javorfi, Tamas; Longo, Edoardo; Rudd, Timothy R; Pulford, Bill; Siligardi, Giuliano

2015-05-01

In the paper by Hussain et al. [(2015), J. Synchrotron Rad. 22, 465-468], Daniel Myatt is missing from the list of authors. The complete list of authors should be Rohanah Hussain, Kristian Benning, Daniel Myatt, Tamas Javorfi, Edoardo Longo, Timothy R. Rudd, Bill Pulford and Giuliano Siligardi.

Real-Time Target Motion Animation for Missile Warning System Testing

Science.gov (United States)

2006-04-01

T. Perkins, R. Sundberg, J. Cordell, Z. Tun , and M. Owen, Real-time Target Motion Animation for Missile Warning System Testing, Proc. SPIE Vol 6208...Z39-18 Real-time target motion animation for missile warning system testing Timothy Perkins*a, Robert Sundberga, John Cordellb, Zaw Tunb, Mark

77 FR 50508 - Change in Bank Control Notices; Formations of, Acquisitions by, and Mergers of Bank Holding...

Science.gov (United States)

2012-08-21

..., Cando, North Dakota; Timothy Dodd and Bradley Fey, both of Bismarck, North Dakota; Jeffrey Topp, Grace City, North Dakota; Janet Topp, Grace City, North Dakota; and Roger Kenner, Leeds, North Dakota; as a... (Jacqueline G. King, Community Affairs Officer) 90 Hennepin Avenue, Minneapolis, Minnesota 55480-0291: 1. MVC...

Cliché, Gossip, and Anecdote as Supervision Training

Science.gov (United States)

Grealy, Liam

2016-01-01

This article expands on a co-authored project with Timothy Laurie on the practices and ethics of higher degree research (HDR) supervision (or advising): "What does good HDR supervision look like?" in contemporary universities. It connects that project with scholarship on the relevance of "common sense" to questions of…

PV Module Reliability Workshop | Photovoltaic Research | NREL

Science.gov (United States)

Gok, Cara Fagerholm, David M. Burns, Timothy J. Peshek, Laura S. Bruckman, Roger H. French Backsheet Chen, C. H. Hsueh, W. J. Hsieh Accurately Measuring PV Power Loss Due to Soiling-Michael Gostein and Walters, Stephen Barkaszi Tracking PV Changes: Bridging Between Thin-Film Cells and Modules-Russell

Teaching Hospital and Other Issues Related to Graduate Medical Education. Hearing before the Subcommittee on Health of the Committee on Ways and Means. House of Representatives, One Hundred Fourth Congress, Second Session (June 11, 1196).

Science.gov (United States)

Congress of the U.S., Washington, DC. House Committee on Ways and Means.

This document reports testimony presented on Medicare financing of graduate medical education, as proposed by the Balanced Budget Act of 1995. Witnesses included: (1) Timothy M. Golddfarb, Director, Healthcare Systems (Oregon), who noted the importance of graduate medical education funding to teaching hospitals; (2) Leo P. Brideau of Strong…

The Relationship between the Learning Organization Concept and Firms' Financial Performance: An Empirical Assessment. [and] Invited Reaction: Linking Learning with Financial Performance.

Science.gov (United States)

Ellinger, Andrea D.; Ellinger, Alexander E.; Yang, Baiyin; Howton, Shelly W.

2002-01-01

Reports on a study of 208 manufacturing managers that found a positive correlation between the seven dimensions of learning organizations and four measures of business financial performance. "Invited Reaction" by Timothy T. Baldwin and Camden C. Danielson critiques the use of key respondent perceptions and bottom-line performance.…

Style and Variables in English.

Science.gov (United States)

Shopen, Timothy, Ed.; Williams, Joseph M., Ed.

A collection of articles on the kinds of variation in English that one finds within the language of one group or one person includes: "The English Language as Rule-Governed Behavior" (Timothy Shopen); "The English Language as Use-Governed Behavior" (Joseph M. Williams); "Styles" (Ann D. Zwicky); "The Organization…

Allergen extracts and recombinant proteins: comparison of efficiency of in vitro allergy diagnostics using multiplex assay on a biological microchip.

Science.gov (United States)

Smoldovskaya, Olga; Feyzkhanova, Guzel; Arefieva, Alla; Voloshin, Sergei; Ivashkina, Olga; Reznikov, Yuriy; Rubina, Alla

2016-01-01

Immunological test systems for diagnostics of type I hypersensitivity involve the following types of antigens: whole allergen extracts, individual highly purified proteins and their recombinant analogues. The goal of this study was to compare the results obtained with whole allergen extracts (birch pollen, cat dander, and timothy grass pollen) and their respective recombinant proteins in biochip-based immunoassay. Multiplex fluorescent immunoassay of 139 patients' blood serum samples was carried out using biological microchips (biochips). sIgE concentrations for the chosen allergens and their recombinant components were measured. ROC analysis was used for comparison of the results and determination of diagnostic accuracy. The results for the birch pollen extract and its recombinant allergens have shown that the diagnostic accuracy of the methods utilizing the whole allergen extract, its major component Bet v 1 and the combination of major and minor components (Bet v 1 and Bet v 2) was the same. Values for diagnostic accuracy for the cat dander extract and its major recombinant component Fel d 1 were equal. In contrast with birch pollen and cat dander allergens, using of recombinant components of timothy grass pollen (Phl p 1, Phl p 5, Phl p 7 and Phl p 12) did not allow reaching the diagnostic accuracy of using natural extract. Multiplex analysis of samples obtained from patients with allergy to birch pollen and cat dander using biological microchips has shown that comparable accuracy was observed for the assay with natural extracts and recombinant allergens. In the case of timothy grass allergen, using the recombinant components may be insufficient.

Festival "Maailmafilm" sobib hästi akadeemilise vaimuga linna / Kadri Rannamäe

Index Scriptorium Estoniae

Rannamäe, Kadri

2008-01-01

V festivali "Maailmafilm", mis algab 24. märtsil Eesti Rahva Muuseumi näitusemajas Tartus, tutvustavad muuseumi direktor Kristjan Raba ja festivali tegevjuht Taavi Tatsi. Esilinastub Liivo Niglase, Diane Perlovi ja Frode Storaasi "Kalarahvas". Kavas on ka eriprogrammid: kirjanikud filmis, klassiku Timothy Aschi filmid Amazonase indiaanlastest ja filmid inimesest linnas

Author Details

African Journals Online (AJOL)

Timothy, EE. Vol 10, No 2 (2011) - Articles Students' perception of teacher's knowledge of subject matter and reading comprehension performance of SS 3 students in Cross River State, Nigeria Abstract PDF. ISSN: 1596-6224. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

Marine Science

African Journals Online (AJOL)

Copy Editor Timothy Andrew. Published ... 2007; Zhou et al., 2009) and they play an important role in the ... At both sites, zonal variation in TMPB was evident with significantly higher C-biomass closer to ... ton is considered to be an essential parameter in eco- systems ...... logical significance of toxic marine dinoflagellates.

Metabolic response to dietary fibre composition in horses

DEFF Research Database (Denmark)

Brøkner, Christine; Austbø, D.; Næsset, J. A.

2016-01-01

. The feed rations consisted of only timothy hay (H), hay plus molassed sugar beet pulp combined with either whole oats (OB) or barley (BB) and hay plus a loose chaff-based concentrate (M). Four horses were fitted with permanent caecal cannulas and liquid caecal content was withdrawn manually and blood...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences. Ardashir K Masouleh. Articles written in Journal of Biosciences. Volume 37 Issue 5 November 2012 pp 829-841 Articles. Application of large-scale sequencing to marker discovery in plants · Robert J Henry Mark Edwards Daniel L E Waters S Gopala Krishnan Peter Bundock Timothy ...

Attracting, Developing, and Maintaining Human Capital: A New Model for Economic Development

Science.gov (United States)

America's Promise Alliance (NJ1), 2011

2011-01-01

"Investing in Kids: Early Childhood Programs and Local Economic Development," a 2011 book by Timothy Bartik, Senior Economist at the W.E. Upjohn Institute for Employment Research, provides a new evidence-based approach for effective economic development. This approach is designed to support business growth and job creation by improving…

Marine Science

African Journals Online (AJOL)

Chief Editor José Paula | Faculty of Sciences of University of Lisbon, Portugal. Copy Editor Timothy Andrew. Published biannually. Aims and scope: The Western Indian Ocean Journal of Marine Science provides an avenue for the wide dissem- ination of high quality research generated in the Western Indian Ocean (WIO) ...

Identification of genes involved in a water stress response in timothy and mapping of orthologous loci in perennial ryegrass

DEFF Research Database (Denmark)

Jonavičienė, Kristina; Studer, Bruno; Asp, Torben

2012-01-01

In order to characterize the response of selected grasses to water stress, relative water content (RWC) in leaves and quantum efficiency of photosystem 2 (Fv/Fm) were measured in Phleum pratense L., P. bertolonii DC. and P. phleoides H. Karst. during 6 d of water stress. The results indicated...... differential responses to water stress among the three Phleum species with higher water deficit sensitivity of P. pratense and P. bertolonii than that of P. phleoides. The cDNA-amplified fragment length polymorphism (cDNA-AFLP) technique was applied to identify differentially expressed genes responding...... to water stress in P. pratense. Cloned and sequenced differentially expressed fragments (DEFs) were used for primer design in order to identify orthologous genes in Lolium perenne L. Twelve genes orthologous to P. pratense DEFs were mapped in the L. perenne mapping population VrnA based on a high...

APA/APAGS Award for Distinguished Graduate Student in Professional Psychology.

Science.gov (United States)

2017-12-01

The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. A qualified candidate must demonstrate exemplary performance in working with an underserved population in an applied setting or have developed an innovative method for delivering health services to an underserved population. The 2017 recipient of the APA/APAGS Award for Distinguished Graduate Student in Professional Psychology was selected by the 2016 Board of Professional Affairs (BPA) and the 2016 APAGS Scholarship and Awards Selection Committee. Members of the 2016 BPA were Antonette M. Zeiss, PhD (Chair); Linda A. Reddy, PhD; Lois O. Condie, PhD; Timothy A. Cavell, PhD; Robert T. Kinscherff, PhD, JD; Jared L. Skillings, PhD, ABPP; Cynthia A. Gómez, PhD; Lisa K. Kearney, PhD, ABPP; and Dinelia Rosa, PhD. Members of the 2016 APAGS Scholarship and Awards Selection Committee were Jerrold Yeo, MA; Jacklynn Fitzgerald, MA; and Roseann Fish Getchell, MA, Med. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Tapping the Power of Poetry

Science.gov (United States)

Rasinski, Timothy

2014-01-01

"I have become increasingly convinced that poetry offers one of the best-and often most underused--resources for developing literacy foundations," writes Timothy Rasinski. Poetry and songs are typically short and easy to learn, provide opportunities for students to play with the sounds of language, and offer an engaging way to learn…

Ada Dual-Use Summary: Ada Dual-Use Workshop Held in Vienna, Virginia on October 19-20, 1993. Ada Dual-Use Committee Briefing, November 8, 1993

Science.gov (United States)

1993-11-29

Systems Agency C- 19 Novemtiber 8., 1993 Promoting the Use of Ada in Computer Science Curricula Timothy J. Long Ohio State University ®I To L4 ease...framework, distributed file systems, a high-performance fiber-optic connection and multi-processor modules to work with the OSF’s Mach 3 microkernel (again

Xpand chest drain: assessing equivalence to current standard ...

African Journals Online (AJOL)

leakage from 'open to air' system or breakage of glass bottle (with associated risk to ... and an air-leak detection system. It is connected to a ... need to add water. Xpand chest drain: assessing equivalence to current standard therapy – a randomised controlled trial. CHARL COOPER, M.B. CH.B. TIMOTHY HARDCASTLE ...

Browse Title Index

African Journals Online (AJOL)

Items 501 - 550 of 823 ... Dario Kuron Lado. Vol 14, No 1 (2009), Patterns of spinal injury in a new neurosurgical centre: A 2-year prospective study, Abstract PDF. JKC Emejulu, OC Ekweogwu, Timothy Nottidge. Vol 18, No 2 (2013), Patterns of Traumatic Intracranial Bleeds at Kenyatta National Hospital in Nairobi, Kenya ...

77 FR 64967 - Senior Executive Service; Performance Review Board

Science.gov (United States)

2012-10-24

... BROWN, STEPHANIE H BRYAN, WILLIAM N BURROWS, CHARLES W BUTTRESS, LARRY D CADIEUX, GENA E CALBOS, PHILIP..., CAROL J BEAMON, JOSEPH A BEARD, JEANNE M BEARD, SUSAN F BEAUSOLEIL, GEOFFREY L BEKKEDAHL, LARRY N BELL..., HENRY C KELLY, JOHN E KELLY, LARRY C KENCHINGTON, HENRY S KENDELL, JAMES M KETCHAM, TIMOTHY E KHAN...

76 FR 77728 - Process for a Designated Contract Market or Swap Execution Facility To Make a Swap Available To...

Science.gov (United States)

2011-12-14

... Mar. 8, 2011 at 2; Letter from Dexter Senft, Morgan Stanley, dated Mar. 2, 2011 at 4; Letter from... from Dexter Senft, Morgan Stanley, dated Mar. 2, 2011 at 4; Letter from Timothy Cameron, Securities... Wayne Pestone, FX Alliance Inc., dated Nov. 4, 2011 at 9-10. \\57\\ Letter from Dexter Senft, Morgan...

EASTERN MYSTICISM AND TIMOTHY LEARY: HUMAN BEYOND THE CONVENTIONAL REALITY

Directory of Open Access Journals (Sweden)

T. V. Danylova

2017-06-01

Full Text Available Introduction. The complex multifaceted essence of human as a biological, psychological, social being has attracted the attention of researchers and has caused hot debates during centuries. Still now, human being, her/his nature requires a broader understanding in the context of the synthesis of long-standing philosophical, psychological, religious traditions and contemporary sciences. Purpose. This paper aims to explore the phenomenon of human being through the lens of the Eastern philosophy and T. Leary’s transpersonal perspective. Methodology. Exploratory research design was used for conducting this study. The author has used philosophical hermeneutics, secondary data collected from reports, journals, and periodicals along with own transpersonal experience. Theoretical basis and results. The essence of Eastern worldview is an awareness of unity and coherence of all things and phenomena. All things are the interdependent and interrelated parts of the One Whole: they are the different manifestations of the same unconditional reality. This is Tao for Taoists, Dharmakaya for Buddhists, Brahman for Hindus. These non-dualistic traditions emphasize: we have to transcend our dual thinking in order to perceive true nature of our inner self and to achieve the state of the absolute unity with everything that exists. “Subject – object” duality is illusory. Being disintegrated from the Oneness, a human is dissociated into different parts. The goal of a new interpretation of a human is to reintegrate these poles and transcend them. Merely theoretical approach to the problem of reintegration is insufficient. Reintegration requires a vivid experience of the “liberation” – the experience of enlightenment. This is a transpersonal experience that overcomes our common perception and goes beyond the usual “body-mind” frame. This experience was breathtakingly described by T. Leary. Experimenting with psilocybin and LSD, T. Leary was astonished that creativity was organically based; that human body contained billions of universes; and that human himself was the movement of various forms of energy. T. Leary proposed his own theory of evolution. Originality. The expansion of human horizons leads us to the new understanding/interpretation of a human being. Bringing the Eastern spiritual traditions, which perceive all objects and phenomena as various interrelated aspects of a single supreme reality, transpersonal psychology and modern sciences together, contemporary philosophers are able to design and develop a new approach to a human that will bridge the gap between different interpretations of a human being. T. Leary’s ideas resonate with both quantum physics and the Eastern philosophy. In the 21st century, T. Leary’s ideas are relevant again. Conclusion. The Eastern spiritual teachings and transpersonal experience put the human problem in a completely different context. It induces us to switch from identifying human beings with the body, mind, ego to embracing them as whole organisms interwoven into the fabric of universal entity. This holistic approach, according to which a human is an undivided, alive and organic, ideal and material being, may be seen as a launching pad for a new transdisciplinary paradigm.

Euroopa tõehetk / Timothy Garton Ash ; tõlkinud Priit Simson

Index Scriptorium Estoniae

Garton Ash, Timothy, 1955-

2009-01-01

Käsitledes kriisi Euroopas, sh. Ida- ja Kesk-Euroopa riikides, ütleb autor, et Euroopa projekti tulevik on küsimärgi all. Edasiminekuks vajab Euroopa praktilist konstruktsiooni, selle saavutamine sõltub globaalsetest jõududest, Euroopa juhtide tasemest ning rahvuslike valijate võimaldatud tegevusruumist ja usaldusest

Autoritaarse kapitalismi pealetung / Timothy Garton Ash ; tõlk. Priit Simson

Index Scriptorium Estoniae

Garton Ash, Timothy, 1955-

2008-01-01

Autor on seisukohal, et 8. augustil teatasid oma naasmisest ajalooareenile kaks suurriiki: Venemaa ja Hiina. Nad on esitanud väljakutse läänele ning esindavad alternatiivseid versioone autoritaarsest kapitalismist või kapitalistlikust autoritarismist

Head töötajad lahkuvad? / Timothy Butler, James Waldroop

Index Scriptorium Estoniae

Butler, Timothy

2006-01-01

Harvardi Ärikooli ärijuhtimisprogrammi juhid avaldasid 1999. aastal artikli "Job sculpting: the art of retaining your best people", milles väljendavad veendumust, et ärialal tegelevaid inimesi motiveerib tegutsema mitte raha, vaid eelkõige nende loomuomased vajadused

Vastavad vennad Quayd / Stephen Quay, Timothy Quay ; interv. Heilika Võsu

Index Scriptorium Estoniae

Quay, Stephen

2006-01-01

IX Pimedate Ööde Filmifestivalil esitlesid animaatoritena tuntud kaksikvennad Quayd oma täispikka mängufimi "Maavärinate klaverihäälestaja" (Piano Tuner of the Earthquakes") : Suurbritannia - Saksamaa - Prantsusmaa 2005. Režissöörid tutvustasid intervjuus ka oma varasemaid tegemisi

Protein Laboratories in Single Location | Poster

Science.gov (United States)

By Andrew Stephen, Timothy Veenstra, and Gordon Whiteley, Guest Writers, and Ken Michaels, Staff Writer The Laboratory of Proteomics and Analytical Technologies (LPAT), Antibody Characterization Laboratory (ACL), and Protein Chemistry Laboratory (PCL), previously located on different floors or in different buildings, are now together on the first floor of C wing in the ATRF.

Mida mõtlevad tippjuhid? / interv. John A. Byrne

Index Scriptorium Estoniae

2008-01-01

USA majandusliku olukorra ja tulevikuprognooside üle arutlevad FedExi juht Fred Smith, Chrysleri tegevjuht Robert Nardell, endine General Electric'u aseesimees Dennis Dammerman, Caritas Christi Health Care tegevjuht Ralph de la Torre, Abbott Labs tegevjuht Miles White, FPL Group tegevjuht Lewis Hay, BorgWarneri tegevjuht Timothy Manganello ning Schering-Plough tegevjuht Fred Hassan

Equine pre-caecal and total tract digestibility of individual carbohydrate fractions and their effect on caecal pH response

DEFF Research Database (Denmark)

Brøkner, Christine; Austbø, Dag; Næsset, Jon Anders

2012-01-01

with a sequence of 17 days adaptation to the ration followed by 8 sampling days. The feed rations consisted of only timothy hay (Group H), hay plus molassed sugar beet pulp combined with either whole oats (Group OB) or barley (Group BB) and hay plus loose chaff based concentrate (Group M). Four horses fitted...

Evaluation of the WavTrac Expeditionary Mobility Matting System

Science.gov (United States)

2017-04-01

Dr. Timothy W. Rushing was Chief, APB; Dr. Gordon W. McMahon was Chief, ESMD; and Nicholas Boone was the Technical Director for Force Projection...were tan in color and had a nonskid material applied to the wearing surface. Typical mat dimensions were 12 ft, 2 in. wide by 48 ft, 6 in. long

Browse Title Index

African Journals Online (AJOL)

Items 1 - 26 of 26 ... Vol 2 (2003), Towards a Richer Intercultural Philosophy for Africa, Abstract. Timothy D Kanakulya. Vol 6, No 1 (2007), Translating policy in the teaching of history: curriculumas a product of an activity system, Abstract. R Nsibande, M Modiba. Vol 2 (2003), Trinidadian Calypso and Mississippi Delta Blues in ...

75 FR 60750 - Granting of Request for Early Termination of the Waiting Period Under the Premerger Notification...

Science.gov (United States)

2010-10-01

...-AUG-10 20100676 G UAL Corporation. G Continental Airlines, Inc. G Continental Airlines, Inc. 20100959 G OCM Principal Opportunities Fund IV, L.P. G Advance Food Company Holdings, Inc. G Advance Food Company, Inc. 20101002 G Alfa S.A.B. de C.V. G Timothy T. Day. G Bar-S Foods Co. 20101019 G Pinafore...

Social Selection and Religiously Selective Faith Schools

Science.gov (United States)

Pettinger, Paul

2014-01-01

This article reviews recent research looking at the socio-economic profile of pupils at faith schools and the contribution religiously selective admission arrangements make. It finds that selection by faith leads to greater social segregation and is open to manipulation. It urges that such selection should end, making the state-funded school…

Een godvechter wordt voorvechter

Directory of Open Access Journals (Sweden)

Rob van Houwelingen

2008-01-01

Full Text Available A godfighter becomes a fighter for God The Pastoral Letters refer twice, in biographical notes, to the religious past of the apostle Paul. In 1 Timothy 1 he is qualified as “a blasphemer and a persecutor and a violent man” (NIV. These qualifications are the stereotypes of a “godfighter", as they are known in secular and early Jewish literature of antiquity. Nevertheless, Paul did not become a recipient of divine vengeance, but of the grace of the Lord. He thus became a fighter for God: the advocate of Christianity. Against this background, how can 2 Timothy 1 state of the same Paul that he, like his Jewish ancestors, has continued to serve God with a clear conscience? This could be seen as a strange discrepancy. Exegesis of both statements in context makes clear, however, that the Pastoral Letters draw a consistent picture of Paul. He had to redefine his faith, but in doing this he did not engage in the worship of any other God than the God of his forefathers.

Feature-selective attention in healthy old age: a selective decline in selective attention?

Science.gov (United States)

Quigley, Cliodhna; Müller, Matthias M

2014-02-12

Deficient selection against irrelevant information has been proposed to underlie age-related cognitive decline. We recently reported evidence for maintained early sensory selection when older and younger adults used spatial selective attention to perform a challenging task. Here we explored age-related differences when spatial selection is not possible and feature-selective attention must be deployed. We additionally compared the integrity of feedforward processing by exploiting the well established phenomenon of suppression of visual cortical responses attributable to interstimulus competition. Electroencephalogram was measured while older and younger human adults responded to brief occurrences of coherent motion in an attended stimulus composed of randomly moving, orientation-defined, flickering bars. Attention was directed to horizontal or vertical bars by a pretrial cue, after which two orthogonally oriented, overlapping stimuli or a single stimulus were presented. Horizontal and vertical bars flickered at different frequencies and thereby elicited separable steady-state visual-evoked potentials, which were used to examine the effect of feature-based selection and the competitive influence of a second stimulus on ongoing visual processing. Age differences were found in feature-selective attentional modulation of visual responses: older adults did not show consistent modulation of magnitude or phase. In contrast, the suppressive effect of a second stimulus was robust and comparable in magnitude across age groups, suggesting that bottom-up processing of the current stimuli is essentially unchanged in healthy old age. Thus, it seems that visual processing per se is unchanged, but top-down attentional control is compromised in older adults when space cannot be used to guide selection.

Resilient Communication: A New Crisis Communication Strategy for Homeland Security

Science.gov (United States)

2012-03-01

communication theory. Author, Timothy Coombs , in Ongoing Crisis Communication , discusses the need for a crisis management 10 plan to prepare for potential... COMMUNICATION : A NEW CRISIS COMMUNICATION STRATEGY FOR HOMELAND SECURITY by Sharon L. Watson March 2012 Thesis Advisor: Christopher Bellavita...REPORT TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE Resilient Communication : A New Crisis Communication

Becoming More Than a Digital Bullhorn: Two Way Engagement on Twitter for Law Enforcement

Science.gov (United States)

2016-03-01

filebank/documents/43341. 174 Coombs , W. Timothy, and Sherry Jean Holladay. “How Publics React to Crisis Communication Efforts: Comparing Crisis ...way communication , crisis communications , followers, open government, transparency, responsiveness, public affairs, public information officer (PIO...for crisis communications is becoming increasingly widespread; the more followers an agency social media account has, the more people they can

Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment | Poster

Science.gov (United States)

Noriho Iida, Amiran Dzutsev, C. Andrew Stewart, Loretta Smith, Nicolas Bouladoux, Rebecca A. Weingarten, Daniel A. Molina, Rosalba Salcedo, Timothy Back, Sarah Cramer, Ren-Ming Dai, Hiu Kiu, Marco Cardone, Shruti Naik, Anil K. Patri, Ena Wang, Francesco M. Marincola, Karen M. Frank, Yasmine Belkaid, Giorgio Trinchieri, Romina S. Goldszmid Science 342(6161):967-970, 2013

User’s Supplement to MIL-STD-740-2 Modified for Measurements to 20 KHz

Science.gov (United States)

1989-10-01

Process Compressor Div. 100 Chemung Street 1 AMI Research Painted Post, NY 14870 2 Captain Walk 1 James Seibert New London, CT 06320 1 Mark Clifton 1...CT 06340-4909 942 Memorial Pkwy. 1 Wilf Kalbach Phillipsburg, NJ 08865 1 David Mewha 1 Timothy Luce 1 Ed Miller 1 Kevin Brimmer 2 ITW Linac 1 Robert

The effect of sugar beet pulp on caecal pH in Norwegian cold-blooded trotter horses

DEFF Research Database (Denmark)

Brøkner, Christine; Austbø, D.; Næsset, J.A.

2010-01-01

It was hypothesised that whole barley would lower caecal pH more thatn whole barley fed in combination with Betfor®. Four geldings were fed two concentrate diets: 2.06 kg whole barley + 300 g DM Befor® (BB) and 2.06 kg whole barley (B). Timothy hay was fed as roughages in both diets. A pH electrode...

The Era of HIV Cure Research | Michael | Annals of Ibadan ...

African Journals Online (AJOL)

Timothy Ray Brown is widely referred to as the first HIV patient to be cured of the disease. He received a CCR5 deficient bone marrow transplant as a treatment for Acute Myeloid Leukemia, with HAART controlled HIV-1 infection at the background. Seven years after the transplant, and discontinuation of HAART, he has been ...

Political Tunings of the Piano

DEFF Research Database (Denmark)

Højlund, Marie Koldkjær; Riis, Morten S.

According to Timothy Morton the creation of ambient art posses an inherent critical potential similar to the ambiguity of the dialectical image found in the writings of Walter Benjamin. Subscribing to an object-oriented ontological understanding of how objects are riven between essence and appear......) as unfolding the ambiguity of various political tunings of the piano....

[Selective mutism].

Science.gov (United States)

Ytzhak, A; Doron, Y; Lahat, E; Livne, A

2012-10-01

Selective mutism is an uncommon disorder in young children, in which they selectively don't speak in certain social situations, while being capable of speaking easily in other social situations. Many etiologies were proposed for selective mutism including psychodynamic, behavioral and familial etc. A developmental etiology that includes insights from all the above is gaining support. Accordingly, mild language impairment in a child with an anxiety trait may be at the root of developing selective mutism. The behavior will be reinforced by an avoidant pattern in the family. Early treatment and followup for children with selective mutism is important. The treatment includes non-pharmacological therapy (psychodynamic, behavioral and familial) and pharmacologic therapy--mainly selective serotonin reuptake inhibitors (SSRI).

Optical diagnostic suite (schlieren, interferometry, and grid image refractometry) on OMEGA EP using a 10-ps, 263-nm probe beama)

Science.gov (United States)

Froula, D. H.; Boni, R.; Bedzyk, M.; Craxton, R. S.; Ehrne, F.; Ivancic, S.; Jungquist, R.; Shoup, M. J.; Theobald, W.; Weiner, D.; Kugland, N. L.; Rushford, M. C.

2012-10-01

A 10-ps, 263-nm (4ω) laser is being built to probe plasmas produced on the OMEGA EP [J. H. Kelly, L. J. Waxer, V. Bagnoud, I. A. Begishev, J. Bromage, B. E. Kruschwitz, T. E. Kessler, S. J. Loucks, D. N. Maywar, R. L. McCrory et al., J. Phys. IV France 133, 75-80 (2006)], 10.1051/jp4:2006133015. A suite of optical diagnostics (schlieren, interferometry, and grid image refractometry) has been designed to diagnose and characterize a wide variety of plasmas. Light scattered by the probe beam is collected by an f/4 catadioptric telescope and a transport system is designed to image with a near-diffraction-limited resolution (˜1 - μm full width at half maximum) over a 5-mm field of view to a diagnostic table. The transport system provides a contrast greater than 1 : 104 with respect to all wavelengths outside of the 263 ± 2 nm measurement range.

Optical diagnostic suite (schlieren, interferometry, and grid image refractometry) on OMEGA EP using a 10-ps, 263-nm probe beam

Energy Technology Data Exchange (ETDEWEB)

Froula, D. H.; Boni, R.; Bedzyk, M.; Craxton, R. S.; Ehrne, F.; Ivancic, S.; Jungquist, R.; Shoup, M. J.; Theobald, W.; Weiner, D. [Laboratory for Laser Energetics, University of Rochester, 250 E. River Rd., Rochester, New York 14616 (United States); Kugland, N. L.; Rushford, M. C. [Lawrence Livermore National Laboratory, University of California, P. O. Box 808, Livermore, California 94551 (United States)

2012-10-15

A 10-ps, 263-nm (4{omega}) laser is being built to probe plasmas produced on the OMEGA EP [J. H. Kelly, L. J. Waxer, V. Bagnoud, I. A. Begishev, J. Bromage, B. E. Kruschwitz, T. E. Kessler, S. J. Loucks, D. N. Maywar, R. L. McCrory et al., J. Phys. IV France 133, 75-80 (2006)]. A suite of optical diagnostics (schlieren, interferometry, and grid image refractometry) has been designed to diagnose and characterize a wide variety of plasmas. Light scattered by the probe beam is collected by an f/4 catadioptric telescope and a transport system is designed to image with a near-diffraction-limited resolution ({approx}1 -{mu}m full width at half maximum) over a 5-mm field of view to a diagnostic table. The transport system provides a contrast greater than 1 : 10{sup 4} with respect to all wavelengths outside of the 263 {+-} 2 nm measurement range.

Optical diagnostic suite (schlieren, interferometry, and grid image refractometry) on OMEGA EP using a 10-ps, 263-nm probe beam.

Science.gov (United States)

Froula, D H; Boni, R; Bedzyk, M; Craxton, R S; Ehrne, F; Ivancic, S; Jungquist, R; Shoup, M J; Theobald, W; Weiner, D; Kugland, N L; Rushford, M C

2012-10-01

A 10-ps, 263-nm (4ω) laser is being built to probe plasmas produced on the OMEGA EP [J. H. Kelly, L. J. Waxer, V. Bagnoud, I. A. Begishev, J. Bromage, B. E. Kruschwitz, T. E. Kessler, S. J. Loucks, D. N. Maywar, R. L. McCrory et al., J. Phys. IV France 133, 75-80 (2006)]. A suite of optical diagnostics (schlieren, interferometry, and grid image refractometry) has been designed to diagnose and characterize a wide variety of plasmas. Light scattered by the probe beam is collected by an f/4 catadioptric telescope and a transport system is designed to image with a near-diffraction-limited resolution (~1 - μm full width at half maximum) over a 5-mm field of view to a diagnostic table. The transport system provides a contrast greater than 1 : 10(4) with respect to all wavelengths outside of the 263 ± 2 nm measurement range.

Optical diagnostic suite (schlieren, interferometry, and grid image refractometry) on OMEGA EP using a 10-ps, 263-nm probe beam

International Nuclear Information System (INIS)

Froula, D. H.; Boni, R.; Bedzyk, M.; Craxton, R. S.; Ehrne, F.; Ivancic, S.; Jungquist, R.; Shoup, M. J.; Theobald, W.; Weiner, D.; Kugland, N. L.; Rushford, M. C.

2012-01-01

A 10-ps, 263-nm (4ω) laser is being built to probe plasmas produced on the OMEGA EP [J. H. Kelly, L. J. Waxer, V. Bagnoud, I. A. Begishev, J. Bromage, B. E. Kruschwitz, T. E. Kessler, S. J. Loucks, D. N. Maywar, R. L. McCrory et al., J. Phys. IV France 133, 75–80 (2006)]. A suite of optical diagnostics (schlieren, interferometry, and grid image refractometry) has been designed to diagnose and characterize a wide variety of plasmas. Light scattered by the probe beam is collected by an f/4 catadioptric telescope and a transport system is designed to image with a near-diffraction-limited resolution (∼1 −μm full width at half maximum) over a 5-mm field of view to a diagnostic table. The transport system provides a contrast greater than 1 : 10 4 with respect to all wavelengths outside of the 263 ± 2 nm measurement range.

Selection for components of complex characteristics - indirect selection

International Nuclear Information System (INIS)

Haensel, H.

1984-01-01

A hierarchy of complexity exists in plant characteristics. The efficiency of indirect selection for a complex characteristic by a sub-trait depends on the heritability of the complex characteristic (hsub(c)), the heritability of the sub-trait (hsub(s)), and the genotypic correlation between sub-trait and complex characteristic (rsub(s.c)). In 1961 hsub(s)Xrsub(s.c)>hsub(c) was postulated, when indirect selection becomes more efficient than direct selection. Numerical examples for this relationship are given and a table for indirect selection for yield in wheat is elaborated. Efficiency ranking of sub-traits in indirect selection may change with climate, conditions of cultivation, the level of other sub-traits, the level of the complex characteristic already reached by breeding, and the breeding material. An example shows that regression analysis for different sub-traits on the same complex characteristic, and an estimation of the differences of the within - and the between - variety slopes, may help to select the more efficient sub-trait. In another example, where simultaneous selection was made for two polygenic characteristics, one directly and the other indirectly by two sub-traits, less than half the F 5 -lines had to be continued, when using the more efficient sub-trait. (author)

Toward a Theory of Strategic Communication: A Relationship Management Approach

Science.gov (United States)

2012-03-22

Washington, DC: U.S. Department of Defense, Aug. 15, 2009), 5. 31 Ibid. 32 Ibid., 6. 33 Ibid. 34 Severin Peters, Strategic Communication for Crisis ...Relations, ed. Robert L. Heath (Thousand Oaks, CA: Sage Publications, 2001), 128. 76 W. Timothy Coombs , “Interpersonal Communication and Public Relations...Toward a Theory of Strategic Communication : A Relationship Management Approach by Lieutenant Colonel Cheryl D. Phillips

Terrestrial Biological Inventory, Hillview Drainage and Levee District, Greene and Scott Counties, Illinois.

Science.gov (United States)

1982-01-01

Timothy) Setaria faberi ’derrm. (Giant Foxtail) Setaria u-tescens (Weigel) Hubb. (Yellow Foxtail) Setaria viridis (L.) Beauv. (Green Foxtail) Spartina...Potamore toa nodosus Poir. (Long-leaved Poadveed) PRIMU]L&CEAE Lysimachia nummalaria L.. (Moneywort) &OSACEAE *Crataegus viridis L. (Southern Thorn... Fragaria vi-riniana Duchesne. (Cultivated Strawberry) Potentilla simplex 1uichx. (Common Cinquef oil) *Prunus americans Marsh. (Wild Plum) *Prunus

Sea-Shore Interface Robotic Design

Science.gov (United States)

2014-06-01

for various beachfront terrains. Robotics , Robot , Amphibious Vehicles, Mobility, Surf-Zone, Autonomous, Wheg, exoskeleton Unclassified Unclassified...controllers and to showcase the benefits of a modular construction. The result was an exoskeleton design with modular components, see Figure 2.1. Figure 2.1...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS SEA-SHORE INTERFACE ROBOTIC DESIGN by Timothy L. Bell June 2014 Thesis Advisor: Richard Harkins

New Attitudes Shaping Labor-District Relations

Science.gov (United States)

Sawchuk, Stephen

2012-01-01

Back in the mid-2000s, in public and in the news media, Joseph P. Burke, then superintendent of the Springfield public schools, and Timothy T. Collins, president of the local teachers' union, often seemed to be at odds with each other. Out of the public eye, however, the two men had begun meeting regularly. When Burke left the district, the work…

E-Unification of Koreas: Dreams, Plans and Realities

Science.gov (United States)

2005-08-01

Calculation, OA; • Medical Electronic Appliances &Program Section - Diagnosis & Treatment Appliances; • Network & Communication / Security, B2B , B2C...Koryo medicine – Consists of preliminary examination, diagnosis, Koryo medical system. Intel- ligent Sales - man Rev- enue & expen diture sys...tem Store sales system. POS (Point of Sales ) Jinung- chulnap -chege POP (Point of Sales ) system Timothy Beal 400 Source ROK DPRK

Muslim Prison Ministry: Hindering the Spread of the Radical, Militant, Violent and Irreconcilable Wing of Islam

Science.gov (United States)

2006-05-25

radical, militant, violent and irreconcilable wing of Islam Approved by: __________________________________ Monograph Director Timothy L . Challans, Ph.D...Honorable Harley Lapin (BOP), Dr. Michael Waller (Institute of World Politics), Mr. Paul Rogers (ACCA), and Mr. A. J. Sabree (ACCA). 78 Ibid., 12...London, United Kingdom: Verso books, 2005. Patai, Raphael. The Arab Mind, Long Island City, NY: Hatherleigh Press, 2002. Pederson , Dick. Defeating

A5: Automated Analysis of Adversarial Android Applications

Science.gov (United States)

2014-06-03

A5: Automated Analysis of Adversarial Android Applications Timothy Vidas, Jiaqi Tan, Jay Nahata, Chaur Lih Tan, Nicolas Christin...detecting, on the device itself, that an application is malicious is much more complex without elevated privileges . In other words, given the...interface via website. Blasing et al. [7] describe another dynamic analysis system for Android . Their system focuses on classifying input applications as

Efficient Multi-Label Feature Selection Using Entropy-Based Label Selection

Directory of Open Access Journals (Sweden)

Jaesung Lee

2016-11-01

Full Text Available Multi-label feature selection is designed to select a subset of features according to their importance to multiple labels. This task can be achieved by ranking the dependencies of features and selecting the features with the highest rankings. In a multi-label feature selection problem, the algorithm may be faced with a dataset containing a large number of labels. Because the computational cost of multi-label feature selection increases according to the number of labels, the algorithm may suffer from a degradation in performance when processing very large datasets. In this study, we propose an efficient multi-label feature selection method based on an information-theoretic label selection strategy. By identifying a subset of labels that significantly influence the importance of features, the proposed method efficiently outputs a feature subset. Experimental results demonstrate that the proposed method can identify a feature subset much faster than conventional multi-label feature selection methods for large multi-label datasets.

Selection gradients, the opportunity for selection, and the coefficient of determination.

Science.gov (United States)

Moorad, Jacob A; Wade, Michael J

2013-03-01

Abstract We derive the relationship between R(2) (the coefficient of determination), selection gradients, and the opportunity for selection for univariate and multivariate cases. Our main result is to show that the portion of the opportunity for selection that is caused by variation for any trait is equal to the product of its selection gradient and its selection differential. This relationship is a corollary of the first and second fundamental theorems of natural selection, and it permits one to investigate the portions of the total opportunity for selection that are involved in directional selection, stabilizing (and diversifying) selection, and correlational selection, which is important to morphological integration. It also allows one to determine the fraction of fitness variation not explained by variation in measured phenotypes and therefore attributable to random (or, at least, unknown) influences. We apply our methods to a human data set to show how sex-specific mating success as a component of fitness variance can be decoupled from that owing to prereproductive mortality. By quantifying linear sources of sexual selection and quadratic sources of sexual selection, we illustrate that the former is stronger in males, while the latter is stronger in females.

Selective mutism.

Science.gov (United States)

Hua, Alexandra; Major, Nili

2016-02-01

Selective mutism is a disorder in which an individual fails to speak in certain social situations though speaks normally in other settings. Most commonly, this disorder initially manifests when children fail to speak in school. Selective mutism results in significant social and academic impairment in those affected by it. This review will summarize the current understanding of selective mutism with regard to diagnosis, epidemiology, cause, prognosis, and treatment. Studies over the past 20 years have consistently demonstrated a strong relationship between selective mutism and anxiety, most notably social phobia. These findings have led to the recent reclassification of selective mutism as an anxiety disorder in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition. In addition to anxiety, several other factors have been implicated in the development of selective mutism, including communication delays and immigration/bilingualism, adding to the complexity of the disorder. In the past few years, several randomized studies have supported the efficacy of psychosocial interventions based on a graduated exposure to situations requiring verbal communication. Less data are available regarding the use of pharmacologic treatment, though there are some studies that suggest a potential benefit. Selective mutism is a disorder that typically emerges in early childhood and is currently conceptualized as an anxiety disorder. The development of selective mutism appears to result from the interplay of a variety of genetic, temperamental, environmental, and developmental factors. Although little has been published about selective mutism in the general pediatric literature, pediatric clinicians are in a position to play an important role in the early diagnosis and treatment of this debilitating condition.

Nasal allergies hayfever among young adults in Melbourne, Australia

Directory of Open Access Journals (Sweden)

Michael Abramson

1997-01-01

Full Text Available Although there is wide variation in the prevalence of nasal allergies internationally, the extent to which this is due to variation in etiological factors is not known. The purpose of the present study was to define the relative importance of atopy and other risk factors for nasal allergies, including hayfever, among young adults in Melbourne. The subjects were participants in the second phase of the European Community Respiratory Health Survey; 876 adults between 20 and 45 years of age completed a detailed respiratory questionnaire, 745 had skin prick testing with common aeroallergens and 675 underwent methacholine challenge. Total and allergen-specific IgE levels were measured in 701 and 693 subjects by radioimmunoassay and RAST, respectively. Nasal allergies, including hayfever, were reported by 47.5% of randomly selected participants. Females, non- smokers, subjects with a family history of allergies, those with current asthma, a history of eczema and nasal symptoms induced by dust, pollen or food were significantly more likely to have nasal allergies. Oral antihistamines had been used by 45.7% of those reporting nasal allergies and 12.4% had received allergen immunotherapy. The risk of nasal allergies, including hayfever, was increased 6.1-fold by atopy, particularly by positive skin tests to outdoor allergens such as Birch, Timothy grass, plantain, olive, Cladosporium and Rye grass pollen. Total serum IgE was significantly higher in subjects reporting nasal allergies than in those who did not report such allergies. There were significant trends in the prevalence of nasal allergies with increasing titers of specific IgE directed against all allergens tested. In conclusion, the significant independent risk factors for nasal allergies, including hayfever, in young adults were atopy, particularly sensitization to Timothy grass, house dust mites and plantain, current asthma, not smoking, a history of eczema and female gender. Future research

Motivation of medical students: selection by motivation or motivation by selection.

Science.gov (United States)

Wouters, Anouk; Croiset, Gerda; Galindo-Garre, Francisca; Kusurkar, Rashmi A

2016-01-29

Medical schools try to implement selection procedures that will allow them to select the most motivated students for their programs. Though there is a general feeling that selection stimulates student motivation, conclusive evidence for this is lacking. The current study aims to use the perspective of Self-determination Theory (SDT) of motivation as a lens to examine how medical students' motivation differs in relation to different selection procedures. The hypotheses were that 1) selected students report higher strength and autonomous motivation than non-selected students, and 2) recently selected students report higher strength and autonomous motivation than non-selected students and students who were selected longer ago. First- (Y1) and fourth-year (Y4) medical students in the six-year regular programme and first-year students in the four-year graduate entry programme (GE) completed questionnaires measuring motivation strength and type (autonomous-AM, controlled-CM). Scores were compared between students admitted based on selection, lottery or top pre-university GPA (top GPA) using ANCOVAs. Selected students' answers on open-ended questions were analysed using inductive thematic analysis to identify reasons for changes in motivation. The response rate was 61.4 % (n = 357). Selected students (Y1, Y4 and GE) reported a significantly higher strength of motivation than non-selected students (Y1 and Y4 lottery and top GPA) (p motivation as they felt autonomous, competent and that they belonged to a special group. These reported reasons are in alignment with the basic psychological needs described by Self-Determination Theory as important in enhancing autonomous motivation. A comprehensive selection procedure, compared to less demanding admission procedures, does not seem to yield a student population which stands out in terms of autonomous motivation. The current findings indicate that selection might temporarily enhance students' motivation. The mechanism

Czytając Snydera. Refleksje białoruskiego historyka

Directory of Open Access Journals (Sweden)

Aleksander Smalanczuk

2013-12-01

Full Text Available Reading Snyder. Reflections of a Belarusian historian Timothy Snyder has carried out a detailed comparison of mass extermination practices of two different though similar regimes. His comparison indicates basic resemblances as well as a large number of discrepancies. At the same time, the conclusions drawn by the author of Bloodlands challenge numerous commonly accepted theses from the field of political history. However, it is easy for a historian from Belarus to notice some inaccuracies regarding the “Belarusian theme.” Timothy Snyder is not familiar with the most important works of Belarusian historiography, which refer to the question of the monograph directly (the works by Jerzy Turonek, Eugeniusz Mironowicz, Igor Kuzniecow and others. Whereas Snyder’s approach to the “Polish theme” lacks some criticism. Nevertheless, Snyder’s book offers quite a comprehensive analysis of the history of mass extermination. Bloodlands demonstrates that the main victim of these murders was Human: death annihilates all national and cultural differences, whereas the most important is the human aspect of the tragedy suffered by the millions, which should not be regarded as statistics.

Rahvuse või kodanike riik? / Timothy Garton Ash ; intervjueerinud Ahto Lobjakas

Index Scriptorium Estoniae

Garton Ash, Timothy, 1955-

2009-01-01

Briti ajaloolane ja politoloog ei usu, et Euroopa Liidu mõistet saaks või tuleks eraldada Euroopa ajaloolisest, geograafilisest ja kultuurilisest järjepidevusest, ta eelistab eripartnerlust nii Türgi kui ka Venemaa puhul, aga mitte liikmestaatust

Kas Euroopa saab Euroopaks? / Timothy Garton Ash ; tõlk. Aet Varik

Index Scriptorium Estoniae

Garton Ash, Timothy, 1955-

2002-01-01

3. aprillil 1996 peetud Sanford S. Elbergi nim. loeng California Ülikooli (Berkeley) Rahvusvaheliste Uuringute Instituudis. Euroopa määratlus enne 1945. aastat, 1945-1989, külma sõja järgsel perioodil ja tänapäeval

Counter-Improvised Explosive Device Fusion Cells and the Brigade Combat Team: A Modern Day Imperative

Science.gov (United States)

2013-12-10

Center Observer Controller/Trainer Mentors. Lieutenant Colonel Kevin Brown , Brigade Special Troop Battalion Lead Observer Controller/Trainer Mentor...December 2010): 13-19. Joint Readiness Training C-IED Lead Observer Controller/Trainer Mentors. Lieutenant Colonel Kevin S. Brown , Brigade Special... Gareth . “How the U.S. Quietly Lost the IED War in Afghanistan.” Inter Press Service News Agency (10 June 2013). Powledge, Timothy R. “Beating the

Auditory Localization Performance with Asymmetric Integrated Eye and Ear Protection

Science.gov (United States)

2018-03-01

Scharine, Morgan Domanico, Ashley N Foots, Kim Fluitt, and Timothy J Mermagen Human Research and Engineering Directorate, ARL Morgan Domanico Oak...prototypes. The AIEEP is a tactical communications and protection system (TCAPS) that also provides eye protection. Participants used a laser pointer...Decibels “A-weighted” is the sound pressure level adjusted for the sensitivity of the average human ear. The reference level is the

Prevention, Preemption, and the Bush Doctrine

Science.gov (United States)

2012-01-30

Just War theorist, Immanuel Kant , addressed directly the issues of preemption and preventive war. Immanuel Kant (1724-1804), while clearly within...51-303, it is not copyrighted, but is the property of the United States government. Biography Chaplain, Lieutenant Colonel Timothy A...understand Kant as being descriptive rather than permissive. This is because he believed that international relations were not exercised in a simple “state

Využití metod koučování v práci školního psychologa a školním prostředí

OpenAIRE

Libert, Tomáš

2010-01-01

The thesis is dealing with potential of improvement of coaching metohods in school psychologist practises and school environment. Theoretical part of the thesis is focused on coaching trends and maping diferent accesses to coaching. The practical part is dealing with specific method of coaching, the Inner Game, which was created by Timothy Gallwey and its utilization in in two cases in school psychologist practise.

Water Resources and Related Land Management, Buffalo Metropolitan Area, New York

Science.gov (United States)

1991-04-01

nettle , Queen Ann’s lace, aster (New England, bushy), beggarstick, cocklebur, chickory, tickseed-sunflower, timothy, teasel, and grasses (quake, orchard...in leaf litter and falling insects off such overhanging trees, that contribute to the fish food chain in the creek. Channelization would disrupt and...alder and eastern cottonwood. Goldenrod, stinging nettle and various grasses are abundant to common. Aquatic vegetation is limited, although spikerush

A Design for Computationally Enabled Analyses Supporting the Pre-Intervention Analytical Framework (PIAF)

Science.gov (United States)

2015-06-01

public release; distribution is unlimited. The US Army Engineer Research and Development Center (ERDC) solves the nation’s toughest engineering and...Framework (PIAF) Timothy K. Perkins and Chris C. Rewerts Construction Engineering Research Laboratory U.S. Army Engineer Research and Development Center...Prepared for U.S. Army Corps of Engineers Washington, DC 20314-1000 Under Project P2 335530, “Cultural Reasoning and Ethnographic Analysis for the

Local Governance and ICTs in Africa : Case Studies and Guidelines ...

International Development Research Centre (IDRC) Digital Library (Canada)

1 août 2011 ... Timothy Mwolo Waema est professeur agrégé à la School of Computing and Informatics de l'Université de Nairobi. Il est titulaire d'un doctorat en gestion stratégique des systèmes d'information de l'Université de Cambridge. Edith Ofwona Adera est spécialiste de programme principale au Bureau régional ...

Joint Force Quarterly. Issue 58, 3rd Quarter

Science.gov (United States)

2010-06-01

frontera chileno-argentina: antesala a una crisis binacional?” Tesis Magister en Seguridad y Defensa, Academia Nacional de Estudios Polí- ticos y...Feature 39 Reorienting Grand Strategy: The Promise of Single-equilibrium Defense Planning By Timothy J. Junio and Jonathan Protz 45 Stabilization...biotechnology and its role in defense planning and policymaking, no definitive book has been written on the topic for the defense policymaker, the

Selective Audiovisual Semantic Integration Enabled by Feature-Selective Attention.

Science.gov (United States)

Li, Yuanqing; Long, Jinyi; Huang, Biao; Yu, Tianyou; Wu, Wei; Li, Peijun; Fang, Fang; Sun, Pei

2016-01-13

An audiovisual object may contain multiple semantic features, such as the gender and emotional features of the speaker. Feature-selective attention and audiovisual semantic integration are two brain functions involved in the recognition of audiovisual objects. Humans often selectively attend to one or several features while ignoring the other features of an audiovisual object. Meanwhile, the human brain integrates semantic information from the visual and auditory modalities. However, how these two brain functions correlate with each other remains to be elucidated. In this functional magnetic resonance imaging (fMRI) study, we explored the neural mechanism by which feature-selective attention modulates audiovisual semantic integration. During the fMRI experiment, the subjects were presented with visual-only, auditory-only, or audiovisual dynamical facial stimuli and performed several feature-selective attention tasks. Our results revealed that a distribution of areas, including heteromodal areas and brain areas encoding attended features, may be involved in audiovisual semantic integration. Through feature-selective attention, the human brain may selectively integrate audiovisual semantic information from attended features by enhancing functional connectivity and thus regulating information flows from heteromodal areas to brain areas encoding the attended features.

Economic Selection Theory

DEFF Research Database (Denmark)

Knudsen, Thorbjørn

2003-01-01

principles of variation, continuity and selection, it is argued that economic selection theory should mimic the causal structure of neo-Darwinian theory. Two of the most influential explanations of economic evolution, Alchian's and Nelson and Winter's, are used to illustrate how this could be achieved.......The present article provides a minimal description of the causal structure of economic selection theory and outlines how the internal selection dynamics of business organisations can be reconciled with selection in competitive markets. In addition to generic similarity in terms of the Darwinian...

A checkerboard selective absorber with excellent spectral selectivity

Energy Technology Data Exchange (ETDEWEB)

Yang, Liu, E-mail: optyang@zju.edu.cn [Centre for Optical and Electromagnetic Research, State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310058 (China); School of Electrical, Computer, and Engineering, Arizona State University, Tempe, Arizona 85287 (United States); Mo, Lei; Chen, Tuo [Centre for Optical and Electromagnetic Research, State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310058 (China); Department of Physics, Zhejiang University, Hangzhou 310027 (China); Forsberg, Erik [Centre for Optical and Electromagnetic Research, State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310058 (China); He, Sailing [Centre for Optical and Electromagnetic Research, State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310058 (China); Department of Electromagnetic Engineering, JORCEP, Roy Institute of Technology (KTH), S-100 44 Stockholm (Sweden)

2015-11-14

A selective absorber with excellent spectral selectivity is proposed and analyzed. The absorber is based on a germanium (Ge) checkerboard on top of a tantalum (Ta) substrate. At wavelengths shorter than the 1.2 μm cutoff, a very high absorption is achieved due to strong cavity resonances in the Ge nanosquares, and their interactions with adjacent nanocavities and the bottom Ta substrate. At longer wavelengths, absorption is greatly suppressed due to destructive interference between the transparent checkerboard layer and the highly reflective Ta substrate. To better describe the superior selectivity of our configuration, a new figure of merit (FOM) is introduced. We observe a FOM value of 0.88 compared to 0.69 for its planar counterpart. We also conduct a thermal analysis to verify the excellent selectivity of our absorber. A high temperature can be achieved and maintained, promising good potential for applications in solar thermophotovoltaic systems.

EDITORIAL: Nanotechnological selection Nanotechnological selection

Science.gov (United States)

Demming, Anna

2013-01-01

At the nanoscale measures can move from a mass-scale analogue calibration to counters of discrete units. The shift redefines the possible levels of control that can be achieved in a system if adequate selectivity can be imposed. As an example as ionic substances pass through nanoscale pores, the quantity of ions is low enough that the pore can contain either negative or positive ions. Yet precise control over this selectivity still raises difficulties. In this issue researchers address the challenge of how to regulate the ionic selectivity of negative and positive charges with the use of an external charge. The approach may be useful for controlling the behaviour, properties and chemical composition of liquids and has possible technical applications for nanofluidic field effect transistors [1]. Selectivity is a critical advantage in the administration of drugs. Nanoparticles functionalized with targeting moieties can allow delivery of anti-cancer drugs to tumour cells, whilst avoiding healthy cells and hence reducing some of the debilitating side effects of cancer treatments [2]. Researchers in Belarus and the US developed a new theranostic approach—combining therapy and diagnosis—to support the evident benefits of cellular selectivity that can be achieved when nanoparticles are applied in medicine [3]. Their process uses nanobubbles of photothermal vapour, referred to as plasmonic nanobubbles, generated by plasmonic excitations in gold nanoparticles conjugated to diagnosis-specific antibodies. The intracellular plasmonic nanobubbles are controlled by laser fluence so that the response can be tuned in individual living cells. Lower fluence allows non-invasive high-sensitive imaging for diagnosis and higher fluence can disrupt the cellular membrane for treatments. The selective response of carbon nanotubes to different gases has leant them to be used within various different types of sensors, as summarized in a review by researchers at the University of

Selective Impairment of Auditory Selective Attention under Concurrent Cognitive Load

Science.gov (United States)

Dittrich, Kerstin; Stahl, Christoph

2012-01-01

Load theory predicts that concurrent cognitive load impairs selective attention. For visual stimuli, it has been shown that this impairment can be selective: Distraction was specifically increased when the stimulus material used in the cognitive load task matches that of the selective attention task. Here, we report four experiments that…

New ion selective materials. Application to the selective extraction of caesium

International Nuclear Information System (INIS)

Favre-Reguillon, Alain

1996-01-01

This research thesis addresses the synthesis and assessment of ion selective materials. The first part reports the development of a general method of assessment of ion selective materials. In the second part, the author describes different methods used to insolubilize macro-cycles on hydrophilic polymers. The obtained polyurethanes are synthesised. These hydrophilic polymers display interesting complexing properties and selectivities with respect to cations of alkali metals. Then the author addresses the improvement of selectivity with respect to caesium of ion exchange resorcinol-formaldehyde resins. Different factors affecting selectivity are identified, and the concept of molecular print is used to study the improvement of selectivity. The effect of macro-cyclic structures on phenolic resins with respect to caesium is highlighted [fr

A Permutation Approach for Selecting the Penalty Parameter in Penalized Model Selection

Science.gov (United States)

Sabourin, Jeremy A; Valdar, William; Nobel, Andrew B

2015-01-01

Summary We describe a simple, computationally effcient, permutation-based procedure for selecting the penalty parameter in LASSO penalized regression. The procedure, permutation selection, is intended for applications where variable selection is the primary focus, and can be applied in a variety of structural settings, including that of generalized linear models. We briefly discuss connections between permutation selection and existing theory for the LASSO. In addition, we present a simulation study and an analysis of real biomedical data sets in which permutation selection is compared with selection based on the following: cross-validation (CV), the Bayesian information criterion (BIC), Scaled Sparse Linear Regression, and a selection method based on recently developed testing procedures for the LASSO. PMID:26243050

IT Project Selection

DEFF Research Database (Denmark)

Pedersen, Keld

2016-01-01

for initiation. Most of the research on project selection is normative, suggesting new methods, but available empirical studies indicate that many methods are seldom used in practice. This paper addresses the issue by providing increased understanding of IT project selection practice, thereby facilitating...... the development of methods that better fit current practice. The study is based on naturalistic decision-making theory and interviews with experienced project portfolio managers who, when selecting projects, primarily rely on political skills, experience and personal networks rather than on formal IT project......-selection methods, and these findings point to new areas for developing new methodological support for IT project selection....

Selective Reproductive Technologies

DEFF Research Database (Denmark)

Gammeltoft, Tine; Wahlberg, Ayo

2014-01-01

From a historical perspective, selective reproduction is nothing new. Infanticide, abandonment, and selective neglect of children have a long history, and the widespread deployment of sterilization and forced abortion in the twentieth century has been well documented. Yet in recent decades select......, discussing how selective reproduction engages with issues of long-standing theoretical concern in anthropology, such as politics, kinship, gender, religion, globalization, and inequality....... (ARTs), what we term selective reproductive technologies (SRTs) are of a more specific nature: Rather than aiming to overcome infertility, they are used to prevent or allow the birth of certain kinds of children. This review highlights anthropological research into SRTs in different parts of the world...

Evaluation of Biodiesel Fuels to Reduce Fossil Fuel Use in Corps of Engineers Floating Plant Operations

Science.gov (United States)

2016-07-01

ER D C/ CH L TR -1 6- 11 Dredging Operations and Environmental Research Program Evaluation of Biodiesel Fuels to Reduce Fossil Fuel Use... Fuels to Reduce Fossil Fuel Use in Corps of Engineers Floating Plant Operations Michael Tubman and Timothy Welp Coastal and Hydraulics Laboratory...sensitive emissions, increase use of renewable energy, and reduce the use of fossil fuels was conducted with funding from the U.S. Army Corps of

Measurements in Regions of Shock Wave/Turbulent Boundary Layer Interaction from Mach 3 to 10 for Open and Blind Code Evaluation/Validation

Science.gov (United States)

2013-03-01

34Blind" Code Evaluation/Validation Michael S. Holden, Timothy P. Wadhams, Matthew G. MacLean, Aaron Dufrene CUBRC , Inc March 2013 Final...298 Back (Rev. 8/98) *Fellow, AIAA, Vice President-Hypersonics, CUBRC , 4455 Genesee Street, Buffalo, NY 14225 ** Member, AIAA, Project Engineers... CUBRC , 4455 Genesee Street, Buffalo, NY 14225 This work was supported by AFOSR Grant No. FA9550-11-1-0290 MEASUREMENTS IN REGIONS OF SHOCK WAVE

Amnesty, Reconciliation and Reintegration: The International Community and the Rwandan Process

Science.gov (United States)

2008-05-22

N., Harvey M. Weinstein , and Timothy Longman. "Trauma and PTSD Symptoms in Rwanda: Implications for Attitudes Toward Justice and Reconciliation...repairing the social fabric of the nation had to take place. The case shows how Rwanda overcame the negative impacts of the international community and...reintegration policies. Throughout the case there are four issues that prove integral to the AR2 process; the anthropology of Rwanda, its colonial

United States Military Academy: 25 Years of Enlightening Research. 2012 Program Review

Science.gov (United States)

2012-01-01

metal transfer data was performed at University of Central Florida. References [1] Cremers , D.A., and Radziemski, L.J., History and Fundamentals of...Cambridge University Press: New York. [2] Cremers , D.A., and Chinni, R.C., Laser-Induced Breakdown Spectroscopy- Capabilites and Limitations...Wagner, David A. Nash, Brian Gollsneider, Thomas R. Moore, Anthony J. Megofna, Timothy J. Talty, James R. Loy, Gregory B. Tait, Diana Thomas, Daniel M

Backstabbing with a chef's knife

OpenAIRE

2010-01-01

Dawson Timothy es el Director de Servicios de Alimentación en el Hotel Graham, prestigioso hotel en una ciudad importante de Estados Unidos. Su currículum es impresionante. El se ha graduado de la mejor escuela, ha puesto en altos niveles los registros de las ventas y beneficios en su último hotel, y ha producido una enorme ganancia en otro hotel que estaba al borde del cierre. Su entrevista,

Net-Centric Sustainment and Operational Reach on the Modern Battlefield

Science.gov (United States)

2012-05-17

Halliday, Marc L. Robbins , and Kenneth J. Girardini. "Sustainment of Army Forces in Operation Iraqi Freedom: Battlefield Logistics and Effects on Operations... Robbins , Kenneth J. Girardini, Rick Eden, John M. Halliday, and Jeffrey Angers. "Operation Iraqi Freedom: Major Findings and Recommendations...Timothy P. Williams, Tony R. Sherrill, Amy R. McGrath, Morris G. Hayes, Antoniette C. McGrady, and John M. Sheckler. "Logistics Command and Control

Approximating Multivariate Normal Orthant Probabilities Using the Clark Algorithm.

Science.gov (United States)

1987-07-15

Kent Eaton Army Research Institute Dr. Hans Crombag 5001 Eisenhower Avenue University of Leyden Alexandria, VA 22333 Education Research Center...Boerhaavelaan 2 Dr. John M. Eddins 2334 EN Leyden University of Illinois The NETHERLANDS 252 Engineering Research Laboratory Mr. Timothy Davey 103 South...Education and Training Ms. Kathleen Moreno Naval Air Station Navy Personnel R&D Center Pensacola, FL 32508 Code 62 San Diego, CA 92152-6800 Dr. Gary Marco

Winning Before the Fight: An Armed Suasion Approach to Countering Near Peer Competition

Science.gov (United States)

2017-05-25

joint doctrine provides a detailed accounting of the types of military operations available short of conflict—including deterrence—implementing those...pdf; Timothy M. Peterson and A. Cooper Drury , “Sanctioning Violence: The Effect of Third-Party Economic Coercion on Militarized Conflict,” The...by presenting a “credible threat of unacceptable counteraction” that raises the cost of the anticipated act beyond the “perceived benefits.”16 In

Contexts of Congressional Decision Behavior

Science.gov (United States)

1979-01-01

Timothy provided nimerous, pleasant distractions along the way and a sense of pride with their question "Daddy--when is your book on Congress going...34 books and scholarly studies,’ 2 2 congressional research and in- 23vestigatory agencies such as General Accounting Office, Congressional Budget...Legislative behavior was roll-call analysis. As mapy analysts have argued, roll-call analysis is based on long distance, secondhand supposition. Researchers

Application of Long Distance Conveyance (LDC) of Dredged Sediments to Louisiana Coastal Restoration

Science.gov (United States)

2011-01-01

generally use some type of bucket for digging the sediment, then hoist or boom the load to the surface. Most common hydraulic methods use a centrifugal...sediment. The loaded bucket is hoisted to the surface and side dumped into a transportation unit, or into the disposal site. Transportation units are...Conveyance (LDC) of Dredged Sediments to Louisiana Coastal Restoration Timothy Welp Coastal and Hydraulics Laboratory U.S. Army Engineer Research

Pressure-induced Formation of Energetic and Structural Extended Solids with Quench-recovery to Ambient Conditions

Science.gov (United States)

2014-06-12

Duck Young Kim. Synthesis of Mg2C: A Magnesium Methanide, Angewandte Chemie International Edition, (08 2013): 0. doi: 10.1002/anie.201303463 TOTAL...Polymorph of2 Magnesium Sesquicarbide, Inorganic Chemistry (02 2014) DuckYoung Kim, Stevce Stefanoski, Oleksandr O. Kurakevych, Timothy A. Strobel...new phase was discovered in the Li+C system. Figure 6 shows x‐ray diffraction and Raman spectra obtained from this phase, which cannot be

Site selection

CERN Multimedia

CERN PhotoLab

1968-01-01

To help resolve the problem of site selection for the proposed 300 GeV machine, the Council selected "three wise men" (left to right, J H Bannier of the Netherlands, A Chavanne of Switzerland and L K Boggild of Denmark).

Ion-selective electrode reviews

CERN Document Server

Thomas, J D R

1983-01-01

Ion-Selective Electrode Reviews, Volume 5 is a collection of articles that covers ion-speciation. The book aims to present the advancements of the range and capabilities of selective ion-sensors. The topics covered in the selection are neutral carrier based ion-selective electrodes; reference electrodes and liquid junction effects in ion-selective electrode potentiometry; ion transfer across water/organic phase boundaries and analytical; and carbon substrate ion-selective electrodes. The text will be of great use to chemists and chemical engineers.

A COMPARATIVE STUDY OF INTRATHECAL DEXMEDETOMIDINE AND FENTANYL AS ADJUVANTS TO BUPIVACAINE FOR LOWER ABDOMINAL SURGERIES

Directory of Open Access Journals (Sweden)

Hari Kishore

2015-01-01

Full Text Available INTRODUCTION: Various adjuvants have been used with local anesthetics in spinal anesthesia to improve the quality of block and to provide prolonged postoperative analgesia. Dexmedetomidine, the new highly selective α2 - agonist drug, is now being used as a neuraxial adju vant. AIM: The aim of this study was to evaluate the onset and duration of sensory and motor block, hemodynamic effect, postoperative analgesia, and adverse effects of dexmedetomidine or fentanyl given intrathecally with hyperbaric 0.5% bupivacaine. METHOD OLOGY: Fifty patients classified in American Society of Anesthesiologists classes I and II scheduled for lower abdominal surgeries were included in this prospective cohort study at Amala Institute of Medical Sciences. Patients received either 15 mg hyperba ric bupivacaine plus 25 μg fentanyl (group 1, n = 25 or 15 mg hyperbaric bupivacaine plus 5 μg dexmedetomidine (group 2, n = 25 intrathecally . RESULTS : Patients in dexmedetomidine group (2 had a significantly longer duration of motor and sensory block t han patients in fentanyl group . (1 The mean time regression of motor block to reach Bromage 0 was 17 6 . 2± 5.71 min in d exmeditomid ine group and 16 6 . 36 ± 5.97 min in fentanyl group (P<0.05. Duration of analgesia was 2 39.52 ± 9.05 min in D exmed i tomidine gro up and 189.96 ± 5.35 min in fentanyl group ( p< 0.05. A significant decrease in heart rate was noted in dexmedetomidine group. CONCLUSION : Intrathecal dexmedetomidine is associated with prolonged duration of analgesia and motor block along with significant dec rease in heart rate.

Comparing Patterns of Natural Selection across Species Using Selective Signatures

Energy Technology Data Exchange (ETDEWEB)

Shapiro, Jesse; Alm, Eric J.

2007-12-01

Comparing gene expression profiles over many different conditions has led to insights that were not obvious from single experiments. In the same way, comparing patterns of natural selection across a set of ecologically distinct species may extend what can be learned from individual genome-wide surveys. Toward this end, we show how variation in protein evolutionary rates, after correcting for genome-wide effects such as mutation rate and demographic factors, can be used to estimate the level and types of natural selection acting on genes across different species. We identify unusually rapidly and slowly evolving genes, relative to empirically derived genome-wide and gene family-specific background rates for 744 core protein families in 30 c-proteobacterial species. We describe the pattern of fast or slow evolution across species as the"selective signature" of a gene. Selective signatures represent aprofile of selection across species that is predictive of gene function: pairs of genes with correlated selective signatures are more likely to share the same cellular function, and genes in the same pathway can evolve in concert. For example,glycolysis and phenylalanine metabolism genes evolve rapidly in Idiomarina loihiensis, mirroring an ecological shift in carbon source from sugars to amino acids. In a broader context, our results suggest that the genomic landscape is organized into functional modules even at the level of natural selection, and thus it may be easier than expected to understand the complex evolutionary pressures on a cell.

Comparing Patterns of Natural Selection Across Species Using Selective Signatures

Energy Technology Data Exchange (ETDEWEB)

Alm, Eric J.; Shapiro, B. Jesse; Alm, Eric J.

2007-12-18

Comparing gene expression profiles over many different conditions has led to insights that were not obvious from single experiments. In the same way, comparing patterns of natural selection across a set of ecologically distinct species may extend what can be learned from individual genome-wide surveys. Toward this end, we show how variation in protein evolutionary rates, after correcting for genome-wide effects such as mutation rate and demographic factors, can be used to estimate the level and types of natural selection acting on genes across different species. We identify unusually rapidly and slowly evolving genes, relative to empirically derived genome-wide and gene family-specific background rates for 744 core protein families in 30 gamma-proteobacterial species. We describe the pattern of fast or slow evolution across species as the 'selective signature' of a gene. Selective signatures represent a profile of selection across species that is predictive of gene function: pairs of genes with correlated selective signatures are more likely to share the same cellular function, and genes in the same pathway can evolve in concert. For example, glycolysis and phenylalanine metabolism genes evolve rapidly in Idiomarina loihiensis, mirroring an ecological shift in carbon source from sugars to amino acids. In a broader context, our results suggest that the genomic landscape is organized into functional modules even at the level of natural selection, and thus it may be easier than expected to understand the complex evolutionary pressures on a cell.

Effective selection of transgenic papaya plants with the PMI/Man selection system.

Science.gov (United States)

Zhu, Yun J; Agbayani, Ricelle; McCafferty, Heather; Albert, Henrik H; Moore, Paul H

2005-09-01

The selectable marker gene phospho-mannose isomerase (pmi), which encodes the enzyme phospho-mannose isomerase (PMI) to enable selection of transformed cell lines on media containing mannose (Man), was evaluated for genetic transformation of papaya (Carica papaya L.). We found that papaya embryogenic calli have little or no PMI activity and cannot utilize Man as a carbon source; however, when calli were transformed with a pmi gene, the PMI activity was greatly increased and they could utilize Man as efficiently as sucrose. Plants regenerated from selected callus lines also exhibited PMI activity but at a lower specific activity level. Our transformation efficiency with Man selection was higher than that reported using antibiotic selection or with a visual marker. For papaya, the PMI/Man selection system for producing transgenic plants is a highly efficient addition to previously published methods for selection and may facilitate the stacking of multiple transgenes of interest. Additionally, since the PMI/Man selection system does not involve antibiotic or herbicide resistance genes, its use might reduce environmental concerns about the potential flow of those genes into related plant populations.

A Bayesian random effects discrete-choice model for resource selection: Population-level selection inference

Science.gov (United States)

Thomas, D.L.; Johnson, D.; Griffith, B.

2006-01-01

Modeling the probability of use of land units characterized by discrete and continuous measures, we present a Bayesian random-effects model to assess resource selection. This model provides simultaneous estimation of both individual- and population-level selection. Deviance information criterion (DIC), a Bayesian alternative to AIC that is sample-size specific, is used for model selection. Aerial radiolocation data from 76 adult female caribou (Rangifer tarandus) and calf pairs during 1 year on an Arctic coastal plain calving ground were used to illustrate models and assess population-level selection of landscape attributes, as well as individual heterogeneity of selection. Landscape attributes included elevation, NDVI (a measure of forage greenness), and land cover-type classification. Results from the first of a 2-stage model-selection procedure indicated that there is substantial heterogeneity among cow-calf pairs with respect to selection of the landscape attributes. In the second stage, selection of models with heterogeneity included indicated that at the population-level, NDVI and land cover class were significant attributes for selection of different landscapes by pairs on the calving ground. Population-level selection coefficients indicate that the pairs generally select landscapes with higher levels of NDVI, but the relationship is quadratic. The highest rate of selection occurs at values of NDVI less than the maximum observed. Results for land cover-class selections coefficients indicate that wet sedge, moist sedge, herbaceous tussock tundra, and shrub tussock tundra are selected at approximately the same rate, while alpine and sparsely vegetated landscapes are selected at a lower rate. Furthermore, the variability in selection by individual caribou for moist sedge and sparsely vegetated landscapes is large relative to the variability in selection of other land cover types. The example analysis illustrates that, while sometimes computationally intense, a

Comparison of 2 Analgesia Modalities in Total Knee Replacement Surgery: Is There an Effect on Knee Function Rehabilitation?

Science.gov (United States)

Zinkus, Janis; Mockutė, Lina; Gelmanas, Arūnas; Tamošiūnas, Ramūnas; Vertelis, Arūnas; Macas, Andrius

2017-06-20

BACKGROUND We compared the effects of continuous femoral nerve block (CFNB) and continuous intraarticular block (CIAB) on pain, functional recovery and adverse effects after total knee arthroplasty (TKA). MATERIAL AND METHODS We prospectively randomized 54 patients undergoing TKA into 2 groups: CFNB (Group F) and CIAB (Group I). Surgery was performed under spinal anesthesia. All patients received patient-controlled analgesia (PCA) with morphine, diclofenac, and acetaminophen for the first 72 h postoperatively. Pain was assessed with a visual analog scale (VAS), 48-h morphine consumption and 72-h local anesthetic dosage were recorded, motor blockade was assessed, maximum range of motion (ROM) was measured, and adverse effect profiles were recorded. RESULTS There was no significant difference in postoperative pain at rest, in passive motion, active motion, or active movement (2-min walk test (2MWT)) between study groups. Group I had less opioid usage in the first 24 h postoperatively (p0.05). Significantly lower scores of Bromage scale in Group I in 72 h after surgery (pknee function on day 7 and at 1 month after surgery.

Natural selection. VII. History and interpretation of kin selection theory.

Science.gov (United States)

Frank, S A

2013-06-01

Kin selection theory is a kind of causal analysis. The initial form of kin selection ascribed cause to costs, benefits and genetic relatedness. The theory then slowly developed a deeper and more sophisticated approach to partitioning the causes of social evolution. Controversy followed because causal analysis inevitably attracts opposing views. It is always possible to separate total effects into different component causes. Alternative causal schemes emphasize different aspects of a problem, reflecting the distinct goals, interests and biases of different perspectives. For example, group selection is a particular causal scheme with certain advantages and significant limitations. Ultimately, to use kin selection theory to analyse natural patterns and to understand the history of debates over different approaches, one must follow the underlying history of causal analysis. This article describes the history of kin selection theory, with emphasis on how the causal perspective improved through the study of key patterns of natural history, such as dispersal and sex ratio, and through a unified approach to demographic and social processes. Independent historical developments in the multivariate analysis of quantitative traits merged with the causal analysis of social evolution by kin selection. © 2013 The Author. Journal of Evolutionary Biology © 2013 European Society For Evolutionary Biology.

IUTAM Symposium

CERN Document Server

Pedley, Timothy

2003-01-01

The IUTAM Symposium on Flow in Collapsible Tubes and Past Other Highly Compliant Boundaries was held on 26-30 March, 2001, at the University of Warwick. As this was the first scientific meeting of its kind we considered it important to mark the occasion by producing a book. Accordingly, at the end of the Symposium the Scientific Committee met to discuss the most appropriate format for the book. We wished to avoid the format of the conventional conference book consisting of a large number of short articles of varying quality. It was agreed that instead we should produce a limited number of rigorously refereed and edited articles by selected participants who would aim to sum up the state of the art in their particular research area. The outcome is the present book. Peter W. Ca rpenter, Warwick Timothy J. Pedley, Cambridge May, 2002. VB SCIENTIFIC COMMITTEE Co-Chair: P.W. Carpenter, Engineering, Warwiek, UK Co-Chair: TJ. Pedley, DAMTP, Cambridge, UK V.V. Babenko, Hydromechanics, Kiev, Ukraine R. Bannasch, Bionik...

Benchmark selection

DEFF Research Database (Denmark)

Hougaard, Jens Leth; Tvede, Mich

2002-01-01

Within a production theoretic framework, this paper considers an axiomatic approach to benchmark selection. It is shown that two simple and weak axioms; efficiency and comprehensive monotonicity characterize a natural family of benchmarks which typically becomes unique. Further axioms are added...... in order to obtain a unique selection...

A novel substance with allelopathic activity in Ginkgo biloba.

Science.gov (United States)

Kato-Noguchi, Hisashi; Takeshita, Sayaka; Kimura, Fukiko; Ohno, Osamu; Suenaga, Kiyotake

2013-12-15

Ginkgo (Ginkgo biloba) is one of the oldest living tree species and has been widely used in traditional medicine. Leaf extracts of ginkgo, such as the standardized extract EGb761, have become one of the best-selling herbal products. However, no bioactive compound directed at plants has been reported in this species. Therefore, we investigated possible allelopathic activity and searched for allelopathically active substances in ginkgo leaves. An aqueous methanol leaf extract inhibited the growth of roots and shoots of garden cress (Lepidium sativum), lettuce (Lactuca sativa), timothy (Phleum pratense) and ryegrass (Lolium multiflorum) seedlings. The extract was purified by several chromatographic runs and an allelopathically active substance was isolated and identified by spectral analysis to be the novel compound 2-hydroxy-6-(10-hydroxypentadec-11-enyl)benzoic acid. The compound inhibited root and shoot growth of garden cress and timothy at concentrations greater than 3 μM. The activity of the compound was 10- to 52-fold that of nonanoic acid. These results suggest that 2-hydroxy-6-(10-hydroxypentadec-11-enyl)benzoic acid may contribute to the allelopathic effect caused by ginkgo leaf extract. The compound may also have potential as a template for the development of new plant control substances. Copyright © 2013 Elsevier GmbH. All rights reserved.

Plant quality and conspecific density effects on Anaphothrips obscurus (Thysanoptera: Thripidae) wing diphenism and population ecology.

Science.gov (United States)

Reisig, Dominic D; Godfrey, Larry D; Marcum, Daniel B

2010-04-01

Factors that influence thysanopteran wing diphenism are not well known. In these studies, the impact of food quality, mediated through nitrogen addition, and conspecific density was explored on the wing diphenism of an herbivorous thrips species (Anaphothrips obscurus Müller) (Thysanoptera: Thripidae). In the first study, nitrogen was added to timothy grass (Phleum pretense L.) (Poales: Poaceae) transplants, and naturally occurring thrips populations were caged on the plants. Thrips abundance and foliar nutrients were assessed every 2 wk. A separate factorial experiment in growth chambers explored the impact of both plant nitrogen addition and thrips abundance on wing diphenism. Thrips density was manipulated by adding either 3 or 40 thrips to potted and caged timothy. Thrips abundance and foliar nutrients were measured 58 d after treatment placement. Plant quality directly affected thrips wing diphenism independent of thrips density in both experiments. Near the end of the field cage experiment, density may have indirectly impacted wing diphenism. In both experiments, plant quality and thrips density interacted to affect thrips population abundance. Plant quality alone can affect thrips wing diphenism, but it remains unclear whether density alone can affect thrips wing diphenism. This is a unique and understudied system that will be useful to examine generalized theories on the negative interaction between reproduction and dispersal.

Diversity of selective and non-selective fishing gear and their impact ...

African Journals Online (AJOL)

This survey was conducted in Al-Kalakla Fishery (KF) and Jabel Awlia Dam Fishery (JADF) in the White Nile River, Khartoum state to identify the selective and non-selective fishing gear. The results showed the selective fishing gear represented by gill-nets and seine nets (beach nets) in both fisheries with clear variation in ...

The ancestral selection graph under strong directional selection.

Science.gov (United States)

Pokalyuk, Cornelia; Pfaffelhuber, Peter

2013-08-01

The ancestral selection graph (ASG) was introduced by  Neuhauser and Krone (1997) in order to study populations of constant size which evolve under selection. Coalescence events, which occur at rate 1 for every pair of lines, lead to joint ancestry. In addition, splitting events in the ASG at rate α, the scaled selection coefficient, produce possible ancestors, such that the real ancestor depends on the ancestral alleles. Here, we use the ASG in the case without mutation in order to study fixation of a beneficial mutant. Using our main tool, a reversibility property of the ASG, we provide a new proof of the fact that a beneficial allele fixes roughly in time (2logα)/α if α is large. Copyright © 2012 Elsevier Inc. All rights reserved.

Selective Serotonin Reuptake Inhibitors for Treatment of Selective Mutism

Directory of Open Access Journals (Sweden)

Mazlum Çöpür

2012-03-01

Full Text Available Some authors suggest that selective mutism should be considered as a variant of social phobia or a disorder in the obsessive-compulsive spectrum. Recent studies indicate that pharmacological treatments may be effective in the treatment of selective mutism. In this article, four cases who were treated with citalopram and escitalopram are presented. The results indicate that the drugs were well tolerated, and the level of social and verbal interactions improved significantly. These findings have shown that citalopram and escitalopram can be considered in medication of selective mutism; nevertheless, it is essential that research be done with more cases than previous ones, in order to prove their accuracy

Management Matters. Selection Policies

Science.gov (United States)

Pappas, Marjorie L.

2003-01-01

One of the most important policy documents for a school library media center is the selection policy or the collection development policy. A well-developed selection policy provides a rationale for the selection decisions made by the school library media specialist. A selection policy represents the criteria against which a challenged book is…

Implications Of Commercial Activity Within Monastic Settlements As A Way To Maintain The Sustainable Development Of Religious Tourism In Romania

OpenAIRE

Gabriela Cecilia Stănciulescu; Alexandra-Maria Ţîrca

2010-01-01

For hundreds years, people have been travelling to places deemed as sacred to meet or to worship Divinity. However, these travels with religious motivation or pilgrimages, which might be considered as the first form of tourism (Rinschede, 1992), were carried out without the possibility to measure the economic, social and environmental impact. Religion-motivated tourism is extremely important in many parts of the world (Timothy and Olsen, 2006). In Romania, religious ceremonies to celebrate Sa...

CRISIS COMMUNICATION: A STUDY OF MALAYSIA AIRLINES' RESPONSE TO THE MH17 CRISIS

OpenAIRE

King, Laura Holdt; Kitchen, Nikolaj Howard; Misimovic, Elvin; Rasmussen, Anne H.W.; Andersen, Kamilla Haugaard

2015-01-01

This project investigates Malaysia Airlines communicative efforts in the MH17-crisis. The theoretical frame consists of W. Timothy Coombs’ Situational Crisis Communication Theory (SCCT) and Image Restoration Theory by William L. Benoit. The Coombs’ analysis entails looking at the contextual factors to develop relevant strategies. Benoit is used as a framework in the textual analysis to explore which strategies MAS employed - scrutinising press releases from the first 48 hours. We compare the ...

Cultivating the Grapevine: An Analysis of Rumor Principles and Concepts

Science.gov (United States)

2015-12-01

the U.K.197 Communications expert Timothy Coombs claims, “most protesters were pro-Tibet and were upset by China’s treatment of Tibet, while other... Crisis Communication : International Perspectives on Hits and Misses, ed. Amiso M. George and Cornelius B. Pratt (New York: Routledge Taylor and Francis...ambiguity and uncertainty.2 As Bordia and Difonzo assert, rumor is a form of interpersonal communication , within a group, which is intended to “reduce

Homegrown Terrorism Inside of Democratic States

Science.gov (United States)

2012-12-14

the Paper The first chapter presents the topic of the thesis in the form of a research question and subordinate questions. The background to the...him) and married Tomoko Ishii in 1978. Her family was moderately well off and provided him with a Chinese herbal medicine business. The business was...Miller, 93 pages. This research study examines the 7/7 London bombings, the Murrah building attack by Timothy McVeigh, and the Japanese religious

U.S. Nuclear Policy, Strategy, and Force Structure: Insights and Issues from the 1994, 2001, and 2010 Nuclear Posture Reviews

Science.gov (United States)

2014-09-01

community.”251 Senator Jeff Sessions, in the April 17, 2013 Hearing to Receive Testimony on Nuclear Forces and Policies, expressed concern that allies...Sagan’s NFU argument, Timothy Fischer , in a U.S. Army War College study from 2012, countered that the United States should retain a policy of possible...nuclear response to WMD because of the important role of ambiguity in national security policy flexibility and deterrence. Fischer recommended that the

The Army Communications Objectives Measurement System (ACOMS): Survey Analysis Plan

Science.gov (United States)

1988-05-01

Analysis Plan 12. PERSONAL AUTHOR(S) Gregory H. Gaertner (Westat) and Timothy W. Elig (ARI), editors 13a. TYPE OF REPORT 13b. TIME COVERED 14. DATE OF...such as those of Lavidge and Steiner (1961), McGuire (1969), and Fishbein and Azjen (1975). Fishbein and Azjen (1975) and Aaker (1975) present...for college, challenge and personal development, or patriotic service). Corresponding to these beliefs are evaluations of the importance of these

Book Reviews

OpenAIRE

Redactie KITLV

2003-01-01

-Timothy Barnard, J.M. Gullick, A history of Selangor (1766-1939). Kuala Lumpur: Malaysian branch of the Royal Asiatic Society, 1989, vi + 220 pp. [MBRAS Monograph 28.] -Okke Braadbaart, Michael L. Ross, Timber booms and institutional breakdown in Southeast Asia. Cambridge: Cambridge University Press, 2001, xvi + 237 pp. -H.J.M. Claessen, Patrick Vinton Kirch ,Hawaiki, ancestral Polynesia; An essay in historical anthropology. Cambridge: Cambridge University Press, 2001, xvii + 375 pp., Roger ...

Preparing General Purpose Forces in the United States and British Armies for Counterinsurgent Operations

Science.gov (United States)

2010-12-10

Operations In Iraq: Planning, Combat, And Occupation,” Thomas Ricks’ Fiasco, and reports by Army historian Major Isaiah Wilson, and former CENCTOM J-4...established Multi-National Forces-Iraq, and Lieutenant General Thomas Metz, commander of the Army’s III Corps, assumed the mantle of Multi-National Corps...Donald P. Wright and Colonel Timothy R. Reese or Thomas Ricks’ Fiasco among other books. 18Dr. Carter Malkasian, “Counterinsurgency in Iraq: May 2003

A Comparison of the Effects of Random Versus Fixed Order of Item Presentation Via the Computer

Science.gov (United States)

1989-02-01

Copies) Dr. Hans Crombag Dr. Stephen Dunbar University of Leyden Lindquist Center Education Research Center for Measurement Boerhaavelaan 2 University of...Iowa 2334 EN Leyden Iowa City, IA 52242 The NETHERLANDS Dr. James A. Earles Dr. Timothy Davey Air Force Human Resources Lab Educational Testing...Montague 4401 Ford Avenue NPRDC Code 13 P.O. Box 16268 San Diego, CA 92152-6800 Alexandria, VA 22302-0268 Ms. Kathleen Moreno Dr..William L. Maloy

The Feasibility and Cost-Effectiveness of Utilizing Skilled Parolees in the United States Armed Forces.

Science.gov (United States)

1980-12-01

total punishment for crime never ends with the courts or jails . None can deny that a criminal record is a life long handicap, and it sub- ject a marked...Operations Ornamental Horticulture Painting & Decorating Plumbing & Pipefitting Radio & TV Repair Sewage Plant Operator Sheet Metal Shoe Repair Tailoring...34 International Journal of Offender Therapy and Comparative Criminology, v. 20, no. 3, pp. 242-245, 1976. 18. Larkin, Timothy, "Removing the Ex-Offenders’ Catch

Pitching Flexible Propulsors: Experimental Assessment of Performance Characteristics

Science.gov (United States)

2014-05-09

McPherson Timothy Snipes Dan Rhodes Tom Price David Majerowicz Louise Becnel Brandon Stanley Joe Dillard Fritz Woolford Bill Beaver Daniel Rodgerson...cogging is more prevalent when there is low or no current in the stator windings, which was the case for the low frequency oscillations that require...less effort from the motor. The experiments were adjusted to only use oscillation frequencies between 2 Hz and 4 Hz, which reduced the prevalence of

The Role of Isolation in Radicalization: How Important Is It?

Science.gov (United States)

2013-12-01

Hug 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT...bully. The bully punched Timothy, and he fled and wept in the car.133 He felt like a failure to his father, who was an accomplished softball player...psychologists who performed interviews with Breivik. His lack of connection with his parents can also be seen in his compendium in he writes extensively

A Nonequilibrium Finite-Rate Carbon Ablation Model for Radiating Earth Re-entry Flows

Science.gov (United States)

2015-09-17

debted to Steven Lewis, Guerric De Crombrugghe de Looringhe, Dr. Troy Eichmann , Dr. Timothy McIntyre, and Dr. Richard Morgan for their assistance in... Eichmann [29]). 20 Figure 8. Side view of UV spectrometer capture area on the model (slit height not to scale, adapted from Zander et al. [133...2011. 29. Eichmann , T. N. Radiation Measurements in a Simulated Mars Atmosphere. Ph.D. thesis, The University of Queensland, 2012. 30. Glass, D. E., R

The Elephant in the Room: Confronting Ideology and Armed Groups

Science.gov (United States)

2010-12-01

World Public Opinion.org, April 24, 2007, http://www.fcnl.org/ pdfs /middle_east/muslim_public_opinion_ pipa.pdf, 21–22. 41 Michael Mousseau...gigantic world conspiracy of probably Satanic origins.59 The term “Patriot movement” (which Neiwert uses because its members use the term for...characterized by a dubious interpretation of the Protestant Bible and the U.S. Constitution. While the bombing by Timothy McVeigh of the Murrah Federal

Improving Uniform Code of Military Justice (UCMJ) Reform

Science.gov (United States)

2014-06-13

U.S. Army.78 Westmoreland and Prugh believed that the military justice system at the time of the Vietnam War was not “combat tested .”79 They conclude...SECDEF-Memo-Comprehensive-Review- of-UCMJ.pdf. 168Timothy M. Phelps , Pentagon Plans Major Review of the Military Justice System, L.A. TIMES, April 15...detailed understanding of politics, psychology , and law are not required. This thesis employs a comparative, epidemiological analysis of multiple

Color selection and location selection in ERPs : differences, similarities and 'neural specificity'

NARCIS (Netherlands)

Lange, J.J.; Wijers, A.A.; Mulder, L.J.M.; Mulder, G.

It was hypothesized that color selection consists of two stages. The first stage represents a feature specific selection in neural populations specialized in processing color. The second stage constitutes feature non-specific selections, related to executive attentional processes and/or motor

Officer Selection (la Selection des officiers)

National Research Council Canada - National Science Library

2000-01-01

.... The theme of this workshop, officer selection, is an issue of central importance to the military forces of all countries, since it determines which individuals, with what characteristics, will...

Spectrally selective glazings

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-08-01

Spectrally selective glazing is window glass that permits some portions of the solar spectrum to enter a building while blocking others. This high-performance glazing admits as much daylight as possible while preventing transmission of as much solar heat as possible. By controlling solar heat gains in summer, preventing loss of interior heat in winter, and allowing occupants to reduce electric lighting use by making maximum use of daylight, spectrally selective glazing significantly reduces building energy consumption and peak demand. Because new spectrally selective glazings can have a virtually clear appearance, they admit more daylight and permit much brighter, more open views to the outside while still providing the solar control of the dark, reflective energy-efficient glass of the past. This Federal Technology Alert provides detailed information and procedures for Federal energy managers to consider spectrally selective glazings. The principle of spectrally selective glazings is explained. Benefits related to energy efficiency and other architectural criteria are delineated. Guidelines are provided for appropriate application of spectrally selective glazing, and step-by-step instructions are given for estimating energy savings. Case studies are also presented to illustrate actual costs and energy savings. Current manufacturers, technology users, and references for further reading are included for users who have questions not fully addressed here.

Simulation of selected genealogies.

Science.gov (United States)

Slade, P F

2000-02-01

Algorithms for generating genealogies with selection conditional on the sample configuration of n genes in one-locus, two-allele haploid and diploid models are presented. Enhanced integro-recursions using the ancestral selection graph, introduced by S. M. Krone and C. Neuhauser (1997, Theor. Popul. Biol. 51, 210-237), which is the non-neutral analogue of the coalescent, enables accessible simulation of the embedded genealogy. A Monte Carlo simulation scheme based on that of R. C. Griffiths and S. Tavaré (1996, Math. Comput. Modelling 23, 141-158), is adopted to consider the estimation of ancestral times under selection. Simulations show that selection alters the expected depth of the conditional ancestral trees, depending on a mutation-selection balance. As a consequence, branch lengths are shown to be an ineffective criterion for detecting the presence of selection. Several examples are given which quantify the effects of selection on the conditional expected time to the most recent common ancestor. Copyright 2000 Academic Press.

Range Selection and Median

DEFF Research Database (Denmark)

Jørgensen, Allan Grønlund; Larsen, Kasper Green

2011-01-01

and several natural special cases thereof. The rst special case is known as range median, which arises when k is xed to b(j 􀀀 i + 1)=2c. The second case, denoted prex selection, arises when i is xed to 0. Finally, we also consider the bounded rank prex selection problem and the xed rank range......Range selection is the problem of preprocessing an input array A of n unique integers, such that given a query (i; j; k), one can report the k'th smallest integer in the subarray A[i];A[i+1]; : : : ;A[j]. In this paper we consider static data structures in the word-RAM for range selection...... selection problem. In the former, data structures must support prex selection queries under the assumption that k for some value n given at construction time, while in the latter, data structures must support range selection queries where k is xed beforehand for all queries. We prove cell probe lower bounds...

Selection, de-selection and progression in German football talent promotion.

Science.gov (United States)

Güllich, Arne

2014-01-01

This study explored to which extent the development of German professional football players is based on early talent identification (TID) and long-term nurture in talent promotion (TP) programmes or on their emergence in the course of repeated procedures of player selection and de-selection in these programmes through childhood and youth. The annual turnover of squad members in national junior teams (2001-2013) and youth elite academies was calculated; national U-team members were followed up with regard to nominations through subsequent seasons and to their success level eventually achieved at senior age; and all current Bundesliga players were analysed retrospectively regarding their earlier involvement in TID/TP programmes. Analyses revealed that the mean annual turnover of squad members was 24.5% (youth academies) and 41.0% (national U-teams), respectively. At any age, the probability of persisting in the programme three years later was <50%. Among current Bundesliga players, the age of recruitment into the TID/TP programme was widely evenly distributed across childhood and youth, respectively. Accordingly, the number of (future) Bundesliga players who were involved in TID/TP was built up continuously through all age categories. The observations suggest that the collective of professional players emerged from repeated procedures of selection and de-selection through childhood and youth rather than from early selection and long-term continuous nurture in TID/TP programmes. The findings are discussed with regard to the uncertainty of TID and of interventions applied to the selected players, and they are related to the individualistic and collectivistic approach in TP.

From demand driven contractor selection towards value driven contractor selection

NARCIS (Netherlands)

Walraven, A.R.; Vries, de B.

2009-01-01

The procurement of a construction contractor should consider more aspects than only cost or price. Taking value and price into account to select the ‘best value for money’ bid results in adopting a structured multicriteria approach. An alternative contractor selection method is presented, which

Binding Mechanisms in Selective Laser Sintering and Selective Laser Melting

NARCIS (Netherlands)

Kruth, J.P.; Mercelis, P.; Van Vaerenbergh, J.; van Vaerenbergh, J.; Froyen, L.; Rombouts, M.

2005-01-01

Purpose – This paper provides an overview of the different binding mechanisms in selective laser sintering (SLS) and selective laser melting (SLM), thus improving the understanding of these processes. Design/methodology/approach – A classification of SLS/SLM processes was developed, based on the

Sexual selection: Another Darwinian process.

Science.gov (United States)

Gayon, Jean

2010-02-01

Why was sexual selection so important to Darwin? And why was it de-emphasized by almost all of Darwin's followers until the second half of the 20th century? These two questions shed light on the complexity of the scientific tradition named "Darwinism". Darwin's interest in sexual selection was almost as old as his discovery of the principle of natural selection. From the beginning, sexual selection was just another "natural means of selection", although different from standard "natural selection" in its mechanism. But it took Darwin 30 years to fully develop his theory, from the early notebooks to the 1871 book The Descent of Man, and Selection in Relation to Sex. Although there is a remarkable continuity in his basic ideas about sexual selection, he emphasized increasingly the idea that sexual selection could oppose the action of natural selection and be non adaptive. In time, he also gave more weight to mate choice (especially female choice), giving explicit arguments in favor of psychological notions such as "choice" and "aesthetic sense". But he also argued that there was no strict demarcation line between natural and sexual selection, a major difficulty of the theory from the beginning. Female choice was the main reason why Alfred Russel Wallace, the co-discoverer of the principle of natural selection, engaged in a major controversy with Darwin about sexual selection. Wallace was suspicious about sexual selection in general, trying to minimize it by all sorts of arguments. And he denied entirely the existence of female choice, because he thought that it was both unnecessary and an anthropomorphic notion. This had something to do with his spiritualist convictions, but also with his conception of natural selection as a sufficient principle for the evolutionary explanation of all biological phenomena (except for the origin of mind). This is why Wallace proposed to redefine Darwinism in a way that excluded Darwin's principle of sexual selection. The main result of

Selective information sampling

Directory of Open Access Journals (Sweden)

Peter A. F. Fraser-Mackenzie

2009-06-01

Full Text Available This study investigates the amount and valence of information selected during single item evaluation. One hundred and thirty-five participants evaluated a cell phone by reading hypothetical customers reports. Some participants were first asked to provide a preliminary rating based on a picture of the phone and some technical specifications. The participants who were given the customer reports only after they made a preliminary rating exhibited valence bias in their selection of customers reports. In contrast, the participants that did not make an initial rating sought subsequent information in a more balanced, albeit still selective, manner. The preliminary raters used the least amount of information in their final decision, resulting in faster decision times. The study appears to support the notion that selective exposure is utilized in order to develop cognitive coherence.

The mechanisms of determiner selection and its relation to lexical selection : An ERP study

NARCIS (Netherlands)

D'Hooge, Elisah; De Baene, W.; Hartsuiker, Robert J

2016-01-01

The language production literature has given only little attention to the dynamics of closed class word selection, such as determiner selection, and its temporal relation to the selection of open class words. The goal of this paper was to investigate whether determiner selection follows serially

Ion-selective electrode reviews

CERN Document Server

Thomas, J D R

1985-01-01

Ion-Selective Electrode Reviews, Volume 7 is a collection of papers that covers the applications of electrochemical sensors, along with the versatility of ion-selective electrodes. The coverage of the text includes solid contact in membrane ion-selective electrodes; immobilized enzyme probes for determining inhibitors; potentiometric titrations based on ion-pair formation; and application of ion-selective electrodes in soil science, kinetics, and kinetic analysis. The text will be of great use to chemists and chemical engineers.

Regaining The Trust Of The American Public: A Law Enforcement Initiative

Science.gov (United States)

2017-12-01

Coombs , Ongoing Crisis Communication , 1st ed. (Los Angeles: SAGE, 2015). 5 to stimulate a crisis , help it develop traction, and cause it to become a...Leadership 6, no. 2 (2016), doi:10.18666/jnel-2016-v6-i2-6996. 21 Coombs , Ongoing Crisis Communication . 22 Ibid, 157. 23 Ibid. 24 Ibid. 25 Ibid...According to leading reputation management expert W. Timothy Coombs , understanding the role of communication during a crisis is essential to protecting

Legalt eller legitimt? Om Nordeas krisekommunikation efter lækagen ’The Panama Papers’

OpenAIRE

Thomsen, Nynne Emilie Vinge

2016-01-01

This thesis examines the way in which Nordea sought to communicate regarding the leak ”The Panama Papers” and how appropriate this turned out to be. Based on William Benoit’s image restoration theory (2015), Timothy W. Coombs’ situational crisis communication theory (2012) and Susanne Holmström’s legitimacy theory (2013), this thesis finds that Nordea mainly used a defensive crisis communication strategy, which was mainly supposed to evade responsibility and minimalize the bank’s role in the ...

Narrow-Band Processing and Fusion Approach for Explosive Hazard Detection in FLGPR

Science.gov (United States)

2011-01-01

Keller, K. C. Ho, Tuan T. Ton, David C. Wong, Mehrdad Soumekh University of Missouri - Columbia Office of Sponsored Programs The Curators of the...Timothy C. Havens* a , James M. Keller a , K.C. Ho a , Tuan T. Ton b , David C. Wong b , and Mehrdad Soumekh c a Dept. of Electrical and Computer...ARO. REFERENCES [1] Cremer , F., Schavemaker, J.G., de Jong, W., and Schutte, K., "Comparison of vehicle-mounted forward-looking polarimetric

The Joseph Barker, Jr. Home: A Comparative Architectural and Historical Study of a 19th Century Brick and Frame Dwelling in Washington County, Ohio,

Science.gov (United States)

1981-02-01

anti-slavery debates of 1836 (Williams 1881: 430) and was deeply involved in Washington County politics. At the arrival of John Quincy Adams during a...433) continued with Adams up the Ohio River as far as Pittsburgh. Barker was a frequent participant in political discussions at the store 29 of... Ansel Wood and ca. 1819 by Timothy Love. Patton (1936: 30), on the other hand, dated the construction to ca. 1832-1836 and stated that it was built

DNA Camouflage

Science.gov (United States)

2016-01-08

1 DNA Camouflage Supplementary Information Bijan Zakeri1,2*, Timothy K. Lu1,2*, Peter A. Carr2,3* 1Department of Electrical Engineering and...ll.mit.edu). Distribution A: Public Release   2 Supplementary Figure 1 DNA camouflage with the 2-state device. (a) In the presence of Cre, DSD-2[α...10 1 + Cre 1 500 1,000 length (bp) chromatogram alignment template − Cre   4 Supplementary Figure 3 DNA camouflage with a switchable

Community Participation and Barriers in Rural Tourism: A Case Study in Kiulu, Sabah

OpenAIRE

Velnisa Paimin N. F.; Modilih S.; Mogindol S. H.; Johnny C.; Thamburaj J. A.

2014-01-01

The paper presents an investigation on local community participation and barriers in rural tourism. It identifies two sides of community participation in tourism as identified by Timothy [5], which are; the benefits point of view and from the decision making process perspective. It also identifies the communities’ barriers in engaging in tourism and uses Tosun’s [18] approach in examining the barriers. A total of eighty-three questionnaire forms were completed by respondents from seven villag...

How Do the Elderly Fare Cross-Nationally? Evidence from the Luxembourg Income Study Project

OpenAIRE

Peter Saunders; Timothy M. Smeeding

1998-01-01

This paper uses microdata from the Luxembourg Income Study How Do the Elderly in Taiwan Fare Cross-Nationally? Evidence from the Luxembourg Income Study Project Peter Saunders and Timothy M. Smeeding Social Policy Research Centre, Discussion Paper, No.81 Abstract This paper uses microdata from the Luxembourg Income Study (LIS) to estimate and compare four dimensions of the well-being of the aged in Taiwan and eight other countries - the United States, Japan, Australia, Poland, Finland, German...

Public Health, Safety, and Security for Mass Gatherings

Science.gov (United States)

2008-05-01

meters28 above and around the crowds along two lines29 near the front and back stretches of the track. The audience was excited to have the plane fly...higher exposure than others, the terrorist expected that at least some people in the audience would get sick in only a few days. Most fans stayed to...Attorney’s Office, Pepsi Center Management, and the Secret Service.” Koerner TJ. (2007, August 10). Prepared remarks of Timothy J. Koerner, Assistant

Effect of intrathecal injection of low-dose bupivacaine coadministered with sufentanil in procedure for prolapse and hemorrhoids%小剂量布比卡因复合舒芬太尼蛛网膜下腔麻醉在吻合器痔上黏膜环切术中的应用

Institute of Scientific and Technical Information of China (English)

卜会敏; 田晓鹏; 刘金山; 谭刚

2017-01-01

目的 探讨小剂量布比卡因复合舒芬太尼蛛网膜下腔注射在吻合器痔上黏膜环切术(PPH)中应用的可行性.方法 择期行PPH的患者60例,随机分为布比卡因复合舒芬太尼组(BS组,n=30)和布比卡因组(B组,n=30).BS组蛛网膜下腔注射布比卡因6 mg复合舒芬太尼2μg的混合液0.9mL,即0.75％布比卡因0.8 mL+0.002％舒芬大尼0.1 mL;B组蛛网膜下腔注射布比卡因10 mg,即0.5％布比卡因2mL.以VAS评分评价术中用吻合器行痔上黏膜环切时的患者不适感,以改良Bromage法评分评价术毕即刻双下肢运动神经阻滞情况,观察麻醉平面、手术医师满意度及术后排尿情况.结果 与B组相比,BS组VAS及改良Bromage法评分降低(P＜0.001),麻醉平面降低(P＜0.001),手术医师满意度升高(P=0.002).两组患者术后排尿情况差异无统计学意义(P =0.250).结论 应用PPH行蛛网膜下腔注射小剂量布比卡因复合舒芬太尼的麻醉效果优于单纯应用布比卡因.%Objective To evaluate the anesthetic effect of intrathecal injection of low dose bupivacaine with sufentanil during procedure for prolapse and hemorrhoids(PPH).Methods Sixty patients who underwent selective operation of PPH were randomly divided into Group BS and Group B,with thirty in each group.Group BS received intrathecal injection of bupivacaine (6 mg) and sufentanil (2 μg),namely,0.75％ bupivacaine (0.8 mL) and 0.002％ sufentanil (0.1 mL).Group B received intrathecal injection of bupivacaine (10 mg) only,namely,0.5％ bupivacaine (2 mL).Patients' discomfort when using anastomosis instruments on hemorrhoids mucosa was evaluated by VAS score.The degree of motor nerve block of lower extremities immediately after surgery was evaluated by revised Bromage score.The level of anesthesia and the performer satisfaction were evaluated.Postoperative micturition situations were recorded.Results Compared with Group B,the VAS and immediate postoperative revised Bromage scores were

Green Supplier Selection Criteria

DEFF Research Database (Denmark)

Nielsen, Izabela Ewa; Banaeian, Narges; Golinska, Paulina

2014-01-01

Green supplier selection (GSS) criteria arise from an organization inclination to respond to any existing trends in environmental issues related to business management and processes, so GSS is integrating environmental thinking into conventional supplier selection. This research is designed...... to determine prevalent general and environmental supplier selection criteria and develop a framework which can help decision makers to determine and prioritize suitable green supplier selection criteria (general and environmental). In this research we considered several parameters (evaluation objectives......) to establish suitable criteria for GSS such as their production type, requirements, policy and objectives instead of applying common criteria. At first a comprehensive and deep review on prevalent and green supplier selection literatures performed. Then several evaluation objectives defined to assess the green...

Identification of recently selected mutations driven by artificial selection in hanwoo (korean cattle).

Science.gov (United States)

Lim, Dajeong; Gondro, Cedric; Park, Hye Sun; Cho, Yong Min; Chai, Han Ha; Seong, Hwan Hoo; Yang, Bo Suk; Hong, Seong Koo; Chang, Won Kyung; Lee, Seung Hwan

2013-05-01

Hanwoo have been subjected over the last seventy years to intensive artificial selection with the aim of improving meat production traits such as marbling and carcass weight. In this study, we performed a signature of selection analysis to identify recent positive selected regions driven by a long-term artificial selection process called a breeding program using whole genome SNP data. In order to investigate homozygous regions across the genome, we estimated iES (integrated Extended Haplotype Homozygosity SNP) for the each SNPs. As a result, we identified two highly homozygous regions that seem to be strong and/or recent positive selection. Five genes (DPH5, OLFM3, S1PR1, LRRN1 and CRBN) were included in this region. To go further in the interpretation of the observed signatures of selection, we subsequently concentrated on the annotation of differentiated genes defined according to the iES value of SNPs localized close or within them. We also described the detection of the adaptive evolution at the molecular level for the genes of interest. As a result, this analysis also led to the identification of OLFM3 as having a strong signal of selection in bovine lineage. The results of this study indicate that artificial selection which might have targeted most of these genes was mainly oriented towards improvement of meat production.

Identification of Recently Selected Mutations Driven by Artificial Selection in Hanwoo (Korean Cattle

Directory of Open Access Journals (Sweden)

Dajeong Lim

2013-05-01

Full Text Available Hanwoo have been subjected over the last seventy years to intensive artificial selection with the aim of improving meat production traits such as marbling and carcass weight. In this study, we performed a signature of selection analysis to identify recent positive selected regions driven by a long-term artificial selection process called a breeding program using whole genome SNP data. In order to investigate homozygous regions across the genome, we estimated iES (integrated Extended Haplotype Homozygosity SNP for the each SNPs. As a result, we identified two highly homozygous regions that seem to be strong and/or recent positive selection. Five genes (DPH5, OLFM3, S1PR1, LRRN1 and CRBN were included in this region. To go further in the interpretation of the observed signatures of selection, we subsequently concentrated on the annotation of differentiated genes defined according to the iES value of SNPs localized close or within them. We also described the detection of the adaptive evolution at the molecular level for the genes of interest. As a result, this analysis also led to the identification of OLFM3 as having a strong signal of selection in bovine lineage. The results of this study indicate that artificial selection which might have targeted most of these genes was mainly oriented towards improvement of meat production.

Site selection handbook: Workshop on site selection for low-level radioactive waste disposal facilities

International Nuclear Information System (INIS)

1987-10-01

The Low-Level Radioactive Waste Policy Amendments Act of 1985 (LLRWPAA) requires the Department of Energy (DOE) to provide technical assistance to ''...those compact regions, host States and nonmember States determined by the Secretary to require assistance.'' Technical assistance has been defined to include, but not be limited to, ''technical guidelines for site selection.'' This site selection workshop was developed to assist States and Compacts in developing new low-level radioactive waste (LLW) disposal sites in accordance with the requirements of the LLRWPAA. The workshop comprises a series of lectures, discussion topics, and exercises, supported by this Site Selection Workshop Handbook, designed to examine various aspects of a comprehensive site selection program. It is not an exhaustive treatment of all aspects of site selection, nor is it prescriptive. The workshop focuses on the major elements of site selection and the tools that can be used to implement the site selection program

Treatment of selective mutism: focus on selective serotonin reuptake inhibitors.

Science.gov (United States)

Kaakeh, Yaman; Stumpf, Janice L

2008-02-01

Abstract Selective mutism is a pediatric psychiatric disorder that occurs when a child consistently fails to speak in specific situations in which speaking is expected, such as at school and social gatherings, but speaks appropriately in other settings. Selective mutism often is diagnosed when a child starts school and does not talk to teachers or peers, but talks to family members at home; the condition is frequently accompanied by anxiety and shyness. Although the underlying etiology of the condition remains unclear, psychotherapy is the preferred initial treatment, with the support of parents and teachers. If the child does not respond to psychotherapy, addition of pharmacologic treatment should be considered, depending on the severity of symptoms and presence of other illnesses. Although data are limited to case reports and trials with small patient populations and short follow-up periods, some patients with selective mutism respond to therapy with selective serotonin reuptake inhibitors (SSRIs). Fluoxetine is the most studied SSRI as treatment for the condition, although further investigation is required to determine the optimal dosage and duration of therapy.

100 years of selection of sugar beet at the Ivanivska research-selection station.

Directory of Open Access Journals (Sweden)

А. С. Лейбович

2009-10-01

Full Text Available In given article the historical way of development of selection of sugar beet at the Ivanivska research-selection station is opened. For 100 years of selection work at station by scientific employees are created and introduced into manufacture over 20 grades of sugar beet.

Ion-selective electrode reviews

CERN Document Server

Thomas, J D R

1982-01-01

Ion-Selective Electrode Reviews, Volume 3, provides a review of articles on ion-selective electrodes (ISEs). The volume begins with an article on methods based on titration procedures for surfactant analysis, which have been developed for discrete batch operation and for continuous AutoAnalyser use. Separate chapters deal with detection limits of ion-selective electrodes; the possibility of using inorganic ion-exchange materials as ion-sensors; and the effect of solvent on potentials of cells with ion-selective electrodes. Also included is a chapter on advances in calibration procedures, the d

Selection signature in domesticated animals.

Science.gov (United States)

Pan, Zhang-yuan; He, Xiao-yun; Wang, Xiang-yu; Guo, Xiao-fei; Cao, Xiao-han; Hu, Wen-ping; Di, Ran; Liu, Qiu-yue; Chu, Ming-xing

2016-12-20

Domesticated animals play an important role in the life of humanity. All these domesticated animals undergo same process, first domesticated from wild animals, then after long time natural and artificial selection, formed various breeds that adapted to the local environment and human needs. In this process, domestication, natural and artificial selection will leave the selection signal in the genome. The research on these selection signals can find functional genes directly, is one of the most important strategies in screening functional genes. The current studies of selection signal have been performed in pigs, chickens, cattle, sheep, goats, dogs and other domestic animals, and found a great deal of functional genes. This paper provided an overview of the types and the detected methods of selection signal, and outlined researches of selection signal in domestic animals, and discussed the key issues in selection signal analysis and its prospects.

Phytoremediation of disturbed lands in Polar Regions of Russia

Science.gov (United States)

Shamsutdinova, Evgeniya

2017-04-01

In the Northern regions the problem of restoration of disturbed lands as a result of anthropogenic activities is particularly acut. A large role for the success of native plants to take hold and re-establish themselves is to allow the natural process to work without human intervention. However observation shows that low reserves of available moisture, poor soil nutrients, exposure to wind and water erosion make impossible of a complete restoration of lands due to natural revegetation. One of the methods used to minimize the effect of these factors is the phytoremediation. Research on the Pelyatinskom gas condensate field in the Taimyr Dolgano-Nenets municipal district revealed the efficacy of biological remediation of awnless brome, wildrye siberian, red fescue and kentucky bluegrass. Geobotanical studies of the tailings fields in Yakutia showed that for the phytoremediation of tailings of alluvial deposits of diamonds slough grass can be successfully used, and on the dumps of coal deposits with a high degree of survival of the willow, poplar, larch, alder stand and pine. Development of technology for remediation of placer gold deposits of the Komsomol mine and Bilibino in Chukotka has shown the effectiveness of sowing common oat, wildrye and larch. The study of the experience of recultivation on objects of the "Transneft-Baltic" in the North-Western Federal district allowed us to select as the recommended mixtures of species: meadow fescue, cocksfoot, timothy grass, white and alsike clover and alfalfa. The multicomponent mixture of red fescue, awnless brome, meadow fescue, timothy grass, couch grass, kentucky bluegrass, beckman's grass were successfully used at the mine of the Bovanenkovo oil and gas condensate field. On the technological grounds of the complex pumping station in the Yamalo-Nenets Autonomous area willows were planted. Pine and willow trees were planted on quarry workings in the Northern taiga of Western Siberia land .Planting of pines has shown

Selection and training

NARCIS (Netherlands)

Sgobba, T.; Landon, L.B.; Marciacq, J.B.; Groen, E.L.; Tikhonov, N.; Torchia, F.

2018-01-01

Selection and training represent two means of ensuring flight crew members are qualified and prepared to perform safely and effectively in space. The first part of the chapter looks at astronaut selection beginning with the evolutionary changes in the US and Russian programs. A discussion of the

Growth and Blood Parameters of Weaned Crossbred Beef Calves Fed Forage Kale (Brassica oleracea spp. acephala

Directory of Open Access Journals (Sweden)

Y. Chorfi

2015-01-01

Full Text Available Forty lightweight calves (206.4±3.2 kg were randomly distributed to four treatments: (Control low nutritive value pasture and hay plus 1 kg d−1 of rolled barley; (Pasture management intensive pasture; (Haylage timothy haylage; and (Kale 50% timothy haylage −50% kale pasture. Blood samples were analysed for thyroid hormones, liver enzymes, glucose, cholesterol, total proteins (TP, albumin, globulins, and urea-N. At the end of the trial, the Pasture group was the heaviest with 323.6±4.2 kg BW and 1.54 kg ADG. Final BW and ADG were similar for the Kale and Haylage groups. Blood T3 was higher for Kale than for the other groups. The T3/T4 ratio was greater for Control at the end of the experiment. There were no treatment differences for T4, aspartate aminotransferase (AST, gamma glutamyl transferase (GGT, glutamate dehydrogenase (GLDH, cholesterol, and glucose. Blood urea-N was lower for Kale and higher for Pasture; however albumin concentrations were greater for Pasture and similar for other treatments. Except for the Control group, calves had a lower concentration of circulating globulins at the end than at the beginning of the experiment. This study showed that Kale could be fed to backgrounding calves without detrimental effects on performance.

Opportunity for natural selection among some selected population groups of Northeast India.

Science.gov (United States)

Das, Farida Ahmed; Mithun, Sikdar

2010-05-01

Selection potential based on differential fertility and mortality has been computed for seven population groups inhabiting different geographical locations of Northeast India. Crow's as well as Johnston and Kensinger's index have been used for the present purpose. Irrespective of the methodology, the total index of selection was found to be highest among the Deoris followed by the Kaibartas. The lowest selection index was found among the Oraon population. If the relative contribution of fertility and mortality components to the total index is considered to be multiplicative, it is observed that in all these communities the fertility component exceeds that of mortality component, which may indicate initiation of demographic transitional phase in the selected populations with the betterment of healthcare and socioeconomic condition within the last few decades.

It Takes Three: Selection, Influence, and De-Selection Processes of Depression in Adolescent Friendship Networks

Science.gov (United States)

Van Zalk, Maarten Herman Walter; Kerr, Margaret; Branje, Susan J. T.; Stattin, Hakan; Meeus, Wim H. J.

2010-01-01

The authors of this study tested a selection-influence-de-selection model of depression. This model explains friendship influence processes (i.e., friends' depressive symptoms increase adolescents' depressive symptoms) while controlling for two processes: friendship selection (i.e., selection of friends with similar levels of depressive symptoms)…

Theory of mind selectively predicts preschoolers' knowledge-based selective word learning.

Science.gov (United States)

Brosseau-Liard, Patricia; Penney, Danielle; Poulin-Dubois, Diane

2015-11-01

Children can selectively attend to various attributes of a model, such as past accuracy or physical strength, to guide their social learning. There is a debate regarding whether a relation exists between theory-of-mind skills and selective learning. We hypothesized that high performance on theory-of-mind tasks would predict preference for learning new words from accurate informants (an epistemic attribute), but not from physically strong informants (a non-epistemic attribute). Three- and 4-year-olds (N = 65) completed two selective learning tasks, and their theory-of-mind abilities were assessed. As expected, performance on a theory-of-mind battery predicted children's preference to learn from more accurate informants but not from physically stronger informants. Results thus suggest that preschoolers with more advanced theory of mind have a better understanding of knowledge and apply that understanding to guide their selection of informants. This work has important implications for research on children's developing social cognition and early learning. © 2015 The British Psychological Society.

Theory of mind selectively predicts preschoolers’ knowledge-based selective word learning

Science.gov (United States)

Brosseau-Liard, Patricia; Penney, Danielle; Poulin-Dubois, Diane

2015-01-01

Children can selectively attend to various attributes of a model, such as past accuracy or physical strength, to guide their social learning. There is a debate regarding whether a relation exists between theory-of-mind skills and selective learning. We hypothesized that high performance on theory-of-mind tasks would predict preference for learning new words from accurate informants (an epistemic attribute), but not from physically strong informants (a non-epistemic attribute). Three- and 4-year-olds (N = 65) completed two selective learning tasks, and their theory of mind abilities were assessed. As expected, performance on a theory-of-mind battery predicted children’s preference to learn from more accurate informants but not from physically stronger informants. Results thus suggest that preschoolers with more advanced theory of mind have a better understanding of knowledge and apply that understanding to guide their selection of informants. This work has important implications for research on children’s developing social cognition and early learning. PMID:26211504

Opportunity structures for selective exposure

DEFF Research Database (Denmark)

Skovsgaard, Morten; Shehata, Adam; Strömbäck, Jesper

2016-01-01

Abstract The transition from low-choice to high-choice media environments has raised new concerns about selective exposure. In this context, two types of selective media exposure are relevant. One is selectivity based on political ideological preferences, the other selectivity based on political...... interest. Evidence for both has been found primarily in an American context, while there is less research on European countries. This is problematic, as the opportunity structures for different forms of selectivity vary across media environments. Against this background, the purpose of this study...

Antibody Contributes to Heterosubtypic Immunity In the Cotton Rat Model of Influenza

Science.gov (United States)

2010-09-29

H1N2 swine influenza virus in pigs previously infected with H1N1 and/or H3N2 subtypes. Vaccine 21: 1375–1381. Wei, C.J., J.C. Boyington, P.M...contributes to heterosubtypic protection against influenza A-induced tachypnea in cotton rats" Name of Candidate: r. Timothy M. Straight Doctor of...Heterosubtypic Immunity In the Cotton Rat Model of Influenza " is appropriately acknowledged and, beyond brief excerpts, is with the permission of the

Army Science Conference Proceedings Held in Orlando, Florida on June 22 - 25, 1992. Volume 2, Principal Authors H Through M.

Science.gov (United States)

1992-06-25

A. See Cooke, P. W. I 291 Evans, Timothy D. See Hansen, John V.E. II 1 Ezzell , John W. See Friedlander, Arthur I 445 Fazi, C. Observation of rf...Network (ALVINN) has demonstrated ARF at speeds up to 104KPH and distances over 20 miles per segment. ALVINN follows defined road edges using a neural...just north of the Kwajalein Atoll, over 5000 miles away. The target launch was monitored and tracked by radars at Vandenburg much in the same way as

Väljavalituse tunne / Jaak Kilmi

Index Scriptorium Estoniae

Kilmi, Jaak, 1973-

2005-01-01

Lühihinnang IX Pimedate Ööde Filmifestivali mängufilmidele - "Garpastum" : režissöör Aleksei German jun : Venemaa 2005, "Kohe paradiisi" ("Paradise Now") : režissöör Hany Abu-Assad : Holland - Saksamaa - Prantsusmaa 2005, "Maavärinate klaverihäälestaja" (Piano Tuner of the Earthquakes") : režissöörid Stephen ja Timothy Quay : Suurbritannia - Saksamaa - Prantsusmaa 2005, "Kolmel ajal" ("Three Times") : režissöör Hou Hsiao-hsien : Taiwan - Hiina 2005

The use of spirometry in a primary care setting

OpenAIRE

Blain, Elizabeth A; Craig, Timothy J

2009-01-01

Elizabeth A Blain, Timothy J CraigPenn State Hershey Medical Center, Hershey, PA, USAObjective: To determine the use of spirometry in family practice, internal medicine, and pediatric outpatient settings.Methods: Data were collected from 45 outpatient offices in the central Pennsylvania area via phone survey that asked a set of four questions: 1) Do you have spirometry in your office? 2) Do you use spirometry for asthma patients? 3) In what situation do you use spirometry for? 4) Do you use s...

Er apostrofen et økologisk instrument?

DEFF Research Database (Denmark)

Lind, Hans

2017-01-01

The article investigates the relationship between the lyrical apostrophe and ecological thinking. Drawing on literary theories and ecological thinkers such as Jane Bennett and Timothy Morton, the article concludes that the apostrophe is related to the concept of ecological sensibility and is usef...... for communicating complex ecological ideas such as coexistence. These conclusions are based on an analysis of several poems containing apostrophes and a discussion of the role of poetry in society and the ability to facilitate ecological thinking and awareness....

A Literature Review of Cultural Resources in Morgan County, Colorado,

Science.gov (United States)

1978-06-02

MILES APPRCXI: %TE LOCATIONS OF SURVEY AREAS 1. NARROWS DAM SURVEY 2. WILDCAT CREEK SURVEY 3. BRUS { FLOOD CO’IOL PROJECT L B3I B LI 0 RAP H Y...Kenneth L. 1975 Edible plants available to aboriginal occupants of the Narrows area. IN Morris, Elizabeth Ann, Bruce J. Lutz, N. Ted Ohr, Timothy J...Reservoi - , Morgan County. Prepared for -1e Riverside IrrigaLion District and Public Service Company of Colorado. Morris, Elizabeth Ann, Bruce J. Lutz, N

Differences in game reading between selected and non-selected youth soccer players.

Science.gov (United States)

Den Hartigh, Ruud J R; Van Der Steen, Steffie; Hakvoort, Bas; Frencken, Wouter G P; Lemmink, Koen A P M

2018-02-01

Applying an established theory of cognitive development-Skill Theory-the current study compares the game-reading skills of youth players selected for a soccer school of a professional soccer club (n = 49) and their non-selected peers (n = 38). Participants described the actions taking place in videos of soccer game plays, and their verbalisations were coded using Skill Theory. Compared to the non-selected players, the selected players generally demonstrated higher levels of complexity in their game-reading, and structured the information of game elements-primarily the player, teammate and field-at higher complexity levels. These results demonstrate how Skill Theory can be used to assess, and distinguish game-reading of youth players with different expertise, a skill important for soccer, but also for other sports.

Evaluation of genomic selection for replacement strategies using selection index theory.

Science.gov (United States)

Calus, M P L; Bijma, P; Veerkamp, R F

2015-09-01

Our objective was to investigate the economic effect of prioritizing heifers for replacement at the herd level based on genomic estimated breeding values, and to compute break-even genotyping costs across a wide range of scenarios. Specifically, we aimed to determine the optimal proportion of preselection based on parent average information for all scenarios considered. Considered replacement strategies include a range of different selection intensities by considering different numbers of heifers available for replacement (15-45 in a herd with 100 dairy cows) as well as different replacement rates (15-40%). Use of conventional versus sexed semen was considered, where the latter resulted in having twice as many heifers available for replacement. The baseline scenario relies on prioritization of replacement heifers based on parent average. The first alternative scenario involved genomic selection of heifers, considering that all heifers were genotyped. The benefits of genomic selection in this scenario were computed using a simple formula that only requires the number of lactating animals, the difference in accuracy between parent average and genomic selection (GS), and the selection intensity as input. When all heifers were genotyped, using GS for replacement of heifers was beneficial in most scenarios for current genotyping prices, provided some room exists for selection, in the sense that at least 2 more heifers are available than needed for replacement. In those scenarios, minimum break-even genotyping costs were equal to half the economic value of a standard deviation of the breeding goal. The second alternative scenario involved a preselection based on parent average, followed by GS among all the preselected heifers. It was in almost all cases beneficial to genotype all heifers when conventional semen was used (i.e., to do no preselection). The optimal proportion of preselection based on parent average was at least 0.63 when sexed semen was used. Use of sexed

Impact of selective genotyping in the training population on accuracy and bias of genomic selection.

Science.gov (United States)

Zhao, Yusheng; Gowda, Manje; Longin, Friedrich H; Würschum, Tobias; Ranc, Nicolas; Reif, Jochen C

2012-08-01

Estimating marker effects based on routinely generated phenotypic data of breeding programs is a cost-effective strategy to implement genomic selection. Truncation selection in breeding populations, however, could have a strong impact on the accuracy to predict genomic breeding values. The main objective of our study was to investigate the influence of phenotypic selection on the accuracy and bias of genomic selection. We used experimental data of 788 testcross progenies from an elite maize breeding program. The testcross progenies were evaluated in unreplicated field trials in ten environments and fingerprinted with 857 SNP markers. Random regression best linear unbiased prediction method was used in combination with fivefold cross-validation based on genotypic sampling. We observed a substantial loss in the accuracy to predict genomic breeding values in unidirectional selected populations. In contrast, estimating marker effects based on bidirectional selected populations led to only a marginal decrease in the prediction accuracy of genomic breeding values. We concluded that bidirectional selection is a valuable approach to efficiently implement genomic selection in applied plant breeding programs.

Selective adsorption of benzhydroxamic acid on fluorite rendering selective separation of fluorite/calcite

Science.gov (United States)

Jiang, Wei; Gao, Zhiyong; Khoso, Sultan Ahmed; Gao, Jiande; Sun, Wei; Pu, Wei; Hu, Yuehua

2018-03-01

Fluorite, a chief source of fluorine in the nature, usually coexists with calcite mineral in ore deposits. Worldwide, flotation techniques with a selective collector and/or a selective depressant are commonly preferred for the separation of fluorite from calcite. In the present study, an attempt was made to use benzhydroxamic acid (BHA) as a collector for the selective separation of fluorite from calcite without using any depressant. Results obtained from the flotation experiments for single mineral and mixed binary minerals revealed that the BHA has a good selective collecting ability for the fluorite when 50 mg/L of BHA was used at pH of 9. The results from the zeta potential and X-ray photoelectron spectroscopy (XPS) indicated that the BHA easily chemisorbs onto the fluorite as compared to calcite. Crystal chemistry calculations showed the larger Ca density and the higher Ca activity on fluorite surface mainly account for the selective adsorption of BHA on fluorite, leading to the selective separation of fluorite from calcite. Moreover, a stronger hydrogen bonding with BHA and the weaker electrostatic repulsion with BHA- also contribute to the stronger interaction of BHA species with fluorite surface.

Genomic selection in plant breeding.

Science.gov (United States)

Newell, Mark A; Jannink, Jean-Luc

2014-01-01

Genomic selection (GS) is a method to predict the genetic value of selection candidates based on the genomic estimated breeding value (GEBV) predicted from high-density markers positioned throughout the genome. Unlike marker-assisted selection, the GEBV is based on all markers including both minor and major marker effects. Thus, the GEBV may capture more of the genetic variation for the particular trait under selection.

Opportunity for natural selection among some selected population groups of Northeast India

Science.gov (United States)

Das, Farida Ahmed; Mithun, Sikdar

2010-01-01

BACKGROUND: Selection potential based on differential fertility and mortality has been computed for seven population groups inhabiting different geographical locations of Northeast India. MATERIALS AND METHODS: Crow’s as well as Johnston and Kensinger’s index have been used for the present purpose. RESULTS AND CONCLUSION: Irrespective of the methodology, the total index of selection was found to be highest among the Deoris followed by the Kaibartas. The lowest selection index was found among the Oraon population. If the relative contribution of fertility and mortality components to the total index is considered to be multiplicative, it is observed that in all these communities the fertility component exceeds that of mortality component, which may indicate initiation of demographic transitional phase in the selected populations with the betterment of healthcare and socioeconomic condition within the last few decades. PMID:21031053

Restaurant Selection in Dublin

OpenAIRE

Cullen, Frank

2012-01-01

The primary objective of this research was to investigate the selection process used by consumers when choosing a restaurant to dine. This study examined literature on consumer behaviour, restaurant selection, and decision-making, underpinning the contention that service quality is linked to the consumer’s selection of a restaurant. It supports the utility theories that consumers buy bundles of attributes that simultaneously combined represent a certain level of service quality at a certain p...

Selective determination of dopamine using quantum-sized gold nanoparticles protected with charge selective ligands

Science.gov (United States)

Kwak, Kyuju; Kumar, S. Senthil; Lee, Dongil

2012-06-01

We report here the selective determination of dopamine (DA) using quantum-sized gold nanoparticles coated with charge selective ligands. Glutathione protected gold nanoparticles (GS-Au25) were synthesized and immobilized into a sol-gel matrix via thiol linkers. The GS-Au25 modified sol-gel electrode was found to show excellent electrocatalytic activity towards the oxidation of DA but no activity towards the oxidation of ascorbic acid. The role of electrostatic charge in the selective electrocatalytic activity of GS-Au25 was verified by voltammetry of redox markers carrying opposite charges. The pH dependent sensitivity for the determination of DA further confirmed the charge screening effect of GS-Au25. Mechanistic investigation revealed that the selectivity is attained by the selective formation of an electrostatic complex between the negatively charged GS-Au25 and DA cation. The GS-Au25 modified sol-gel electrode also showed excellent selectivity for DA in the presence of an interferent, ascorbic acid.We report here the selective determination of dopamine (DA) using quantum-sized gold nanoparticles coated with charge selective ligands. Glutathione protected gold nanoparticles (GS-Au25) were synthesized and immobilized into a sol-gel matrix via thiol linkers. The GS-Au25 modified sol-gel electrode was found to show excellent electrocatalytic activity towards the oxidation of DA but no activity towards the oxidation of ascorbic acid. The role of electrostatic charge in the selective electrocatalytic activity of GS-Au25 was verified by voltammetry of redox markers carrying opposite charges. The pH dependent sensitivity for the determination of DA further confirmed the charge screening effect of GS-Au25. Mechanistic investigation revealed that the selectivity is attained by the selective formation of an electrostatic complex between the negatively charged GS-Au25 and DA cation. The GS-Au25 modified sol-gel electrode also showed excellent selectivity for DA in the

GIS-based identification of areas that have resource potential for critical minerals in six selected groups of deposit types in Alaska

Science.gov (United States)

Karl, Susan M.; Jones, James V.; Hayes, Timothy S.

2016-11-16

each 12-digit hydrologic unit through color shading. Accompanying tables describe the data layers employed to score favorability for the presence of each mineral deposit group, the values assigned for specific analysis parameters, and the relative weighting of each data layer that contributes to estimated measures of potential and certainty. Core datasets used include the Alaska Geochemical Database, Version 2.0 (AGDB2); the Alaska Division of Geological & Geophysical Surveys (ADGGS) web-based geochemical database; the digital “Geologic Map of Alaska;” the Alaska Resource Data File (ARDF); and aerial gamma-ray surveys flown as part of the National Uranium Resource Evaluation (NURE) Program by the U.S. Department of Energy.Maps accompanying this report illustrate the scores for estimated mineral resource potential for the six deposit groups for the state of Alaska. Areas that have known potential, as well as new areas that were not previously known to have potential, for the targeted minerals and deposit groups are identified and described. Numerous areas in Alaska, some of them large, have high potential for one or more of the selected groups of deposit types within Alaska.ContributorsMatthew Granitto, Timothy S. Hayes, James V. Jones, III, Susan M. Karl, Keith A. Labay, Jeffrey L. Mauk, Jeanine M. Schmidt, Nora B. Shew, Erin Todd, Bronwen Wang, Melanie B. Werdon, and Douglas B. Yager

BSL-3 laboratory practices in the United States: comparison of select agent and non-select agent facilities.

Science.gov (United States)

Richards, Stephanie L; Pompei, Victoria C; Anderson, Alice

2014-01-01

New construction of biosafety level 3 (BSL-3) laboratories in the United States has increased in the past decade to facilitate research on potential bioterrorism agents. The Centers for Disease Control and Prevention inspect BSL-3 facilities and review commissioning documentation, but no single agency has oversight over all BSL-3 facilities. This article explores the extent to which standard operating procedures in US BSL-3 facilities vary between laboratories with select agent or non-select agent status. Comparisons are made for the following variables: personnel training, decontamination, personal protective equipment (PPE), medical surveillance, security access, laboratory structure and maintenance, funding, and pest management. Facilities working with select agents had more complex training programs and decontamination procedures than non-select agent facilities. Personnel working in select agent laboratories were likely to use powered air purifying respirators, while non-select agent laboratories primarily used N95 respirators. More rigorous medical surveillance was carried out in select agent workers (although not required by the select agent program) and a higher level of restrictive access to laboratories was found. Most select agent and non-select agent laboratories reported adequate structural integrity in facilities; however, differences were observed in personnel perception of funding for repairs. Pest management was carried out by select agent personnel more frequently than non-select agent personnel. Our findings support the need to promote high quality biosafety training and standard operating procedures in both select agent and non-select agent laboratories to improve occupational health and safety.

Compressors selection and sizing

CERN Document Server

Brown, Royce N

2005-01-01

This practical reference provides in-depth information required to understand and properly estimate compressor capabilities and to select the proper designs. Engineers and students will gain a thorough understanding of compression principles, equipment, applications, selection, sizing, installation, and maintenance. The many examples clearly illustrate key aspects to help readers understand the ""real world"" of compressor technology.Compressors: Selection and Sizing, third edition is completely updated with new API standards. Additions requested by readers include a new section on di

The site selection process

International Nuclear Information System (INIS)

Kittel, J.H.

1989-01-01

One of the most arduous tasks associated with the management of radioactive wastes is the siting of new disposal facilities. Experience has shown that the performance of the disposal facility during and after disposal operations is critically dependent on the characteristics of the site itself. The site selection process consists of defining needs and objectives, identifying geographic regions of interest, screening and selecting candidate sites, collecting data on the candidate sites, and finally selecting the preferred site. Before the site selection procedures can be implemented, however, a formal legal system must be in place that defines broad objectives and, most importantly, clearly establishes responsibilities and accompanying authorities for the decision-making steps in the procedure. Site selection authorities should make every effort to develop trust and credibility with the public, local officials, and the news media. The responsibilities of supporting agencies must also be spelled out. Finally, a stable funding arrangement must be established so that activities such as data collection can proceed without interruption. Several examples, both international and within the US, are given

Cermet based solar selective absorbers : further selectivity improvement and developing new fabrication technique

OpenAIRE

Nejati, Mohammadreza

2008-01-01

Spectral selectivity of cermet based selective absorbers were increased by inducing surface roughness on the surface of the cermet layer using a roughening technique (deposition on hot substrates) or by micro-structuring the metallic substrates before deposition of the absorber coating using laser and imprint structuring techniques. Cu-Al2O3 cermet absorbers with very rough surfaces and excellent selectivity were obtained by employing a roughness template layer under the infrared reflective l...

Mutation-selection models of codon substitution and their use to estimate selective strengths on codon usage

DEFF Research Database (Denmark)

Yang, Ziheng; Nielsen, Rasmus

2008-01-01

Current models of codon substitution are formulated at the levels of nucleotide substitution and do not explicitly consider the separate effects of mutation and selection. They are thus incapable of inferring whether mutation or selection is responsible for evolution at silent sites. Here we impl...... codon usage in mammals. Estimates of selection coefficients nevertheless suggest that selection on codon usage is weak and most mutations are nearly neutral. The sensitivity of the analysis on the assumed mutation model is discussed.......Current models of codon substitution are formulated at the levels of nucleotide substitution and do not explicitly consider the separate effects of mutation and selection. They are thus incapable of inferring whether mutation or selection is responsible for evolution at silent sites. Here we...... implement a few population genetics models of codon substitution that explicitly consider mutation bias and natural selection at the DNA level. Selection on codon usage is modeled by introducing codon-fitness parameters, which together with mutation-bias parameters, predict optimal codon frequencies...

Selection in artistic gymnastics

Directory of Open Access Journals (Sweden)

Maria Olaru

2009-06-01

Full Text Available This study envisages the analysis of the specific aspects of the selection process in artistic gymnastics, focusing particularly onthe selection of Romania’s recent years. In our opinion, the shift to a cone of darkness of the artistic gymnastics, an extremelypopular sport in our country 20 years ago, is also based on and the orientation of children to other fields – unfortunately manyof them outside sports and physical activities in general. In the present study, we shall present the stages of the artisticgymnastics, as its importance in the subsequent performances has been proven a long time ago. The plethora of qualities andskills which are necessary to select a child for gymnastics and those that this sport develops when performed as a spare timeactivity. The case studied in this endeavour is the one of the main centers for gymnast recruitment in Romania; the attentionpaid by the trainers to the selection for this sport makes the data regarding the number of children involved to increase oncemore. This is a satisfactory fact as it is a well-known fact that a wide range primary selection sets a serious basis for thesecondary selection, and the third, respectively, envisaging the future performance and concurrently ensures the involvementof more children in a physical activity that will prepare them, both physically and mentally for a healthy life.

Additive Manufacturing Processes: Selective Laser Melting, Electron Beam Melting and Binder Jetting-Selection Guidelines.

Science.gov (United States)

Gokuldoss, Prashanth Konda; Kolla, Sri; Eckert, Jürgen

2017-06-19

Additive manufacturing (AM), also known as 3D printing or rapid prototyping, is gaining increasing attention due to its ability to produce parts with added functionality and increased complexities in geometrical design, on top of the fact that it is theoretically possible to produce any shape without limitations. However, most of the research on additive manufacturing techniques are focused on the development of materials/process parameters/products design with different additive manufacturing processes such as selective laser melting, electron beam melting, or binder jetting. However, we do not have any guidelines that discuss the selection of the most suitable additive manufacturing process, depending on the material to be processed, the complexity of the parts to be produced, or the design considerations. Considering the very fact that no reports deal with this process selection, the present manuscript aims to discuss the different selection criteria that are to be considered, in order to select the best AM process (binder jetting/selective laser melting/electron beam melting) for fabricating a specific component with a defined set of material properties.

Additive Manufacturing Processes: Selective Laser Melting, Electron Beam Melting and Binder Jetting—Selection Guidelines

Science.gov (United States)

Konda Gokuldoss, Prashanth; Kolla, Sri; Eckert, Jürgen

2017-01-01

Additive manufacturing (AM), also known as 3D printing or rapid prototyping, is gaining increasing attention due to its ability to produce parts with added functionality and increased complexities in geometrical design, on top of the fact that it is theoretically possible to produce any shape without limitations. However, most of the research on additive manufacturing techniques are focused on the development of materials/process parameters/products design with different additive manufacturing processes such as selective laser melting, electron beam melting, or binder jetting. However, we do not have any guidelines that discuss the selection of the most suitable additive manufacturing process, depending on the material to be processed, the complexity of the parts to be produced, or the design considerations. Considering the very fact that no reports deal with this process selection, the present manuscript aims to discuss the different selection criteria that are to be considered, in order to select the best AM process (binder jetting/selective laser melting/electron beam melting) for fabricating a specific component with a defined set of material properties. PMID:28773031

Nitrate and bicarbonate selective CHEMFETs

NARCIS (Netherlands)

Antonisse, M.M.G.; Engbersen, Johannes F.J.; Reinhoudt, David

1995-01-01

The development of durable anion selective CHEMFET micro sensors is described. Selectivity in these sensors is either obtained from differences in hydration energy of the anions (the Hlofmeister series, giving nitrate selectivity) or by introduction of a new class of uranyl salophene ionophores

Kuhu nüüd, Euroopa? / Timothy Garton Ash ; tõlkinud Janek Salme

Index Scriptorium Estoniae

Garton Ash, Timothy, 1955-

2009-01-01

Autori arvates pole praegune Euroopa suuremeelne Euroopa, millest unistasid 1989. a. visionäärid, ning on küsimus, kas suudame tagasi saada osa tolleaegsest strateegilisest julgusest ja ajalooliselt kujutlusvõimest

The Urlinie in Hindemith's String quartet op. 22, second movement / Timothy L. Jackson

Index Scriptorium Estoniae

Jackson, Timothy L.

2008-01-01

Hindemithi Neljanda keelpillikvarteti 2. osa muusikaanalüüs. Muusikalooline taust Paul Hindemithi, Heinrich Schenkeri, Wilhelm Furtwängleri, Bruno Stürmeri ja Gerhard Albersheimi kirjavahetuse varal. Artikli lõpus saksakeelsed originaalkirjad

Opportunistic relaying in multipath and slow fading channel: Relay selection and optimal relay selection period

KAUST Repository

Sungjoon Park,

2011-11-01

In this paper we present opportunistic relay communication strategies of decode and forward relaying. The channel that we are considering includes pathloss, shadowing, and fast fading effects. We find a simple outage probability formula for opportunistic relaying in the channel, and validate the results by comparing it with the exact outage probability. Also, we suggest a new relay selection algorithm that incorporates shadowing. We consider a protocol of broadcasting the channel gain of the previously selected relay. This saves resources in slow fading channel by reducing collisions in relay selection. We further investigate the optimal relay selection period to maximize the throughput while avoiding selection overhead. © 2011 IEEE.

Sexual selection protects against extinction.

Science.gov (United States)

Lumley, Alyson J; Michalczyk, Łukasz; Kitson, James J N; Spurgin, Lewis G; Morrison, Catriona A; Godwin, Joanne L; Dickinson, Matthew E; Martin, Oliver Y; Emerson, Brent C; Chapman, Tracey; Gage, Matthew J G

2015-06-25

Reproduction through sex carries substantial costs, mainly because only half of sexual adults produce offspring. It has been theorized that these costs could be countered if sex allows sexual selection to clear the universal fitness constraint of mutation load. Under sexual selection, competition between (usually) males and mate choice by (usually) females create important intraspecific filters for reproductive success, so that only a subset of males gains paternity. If reproductive success under sexual selection is dependent on individual condition, which is contingent to mutation load, then sexually selected filtering through 'genic capture' could offset the costs of sex because it provides genetic benefits to populations. Here we test this theory experimentally by comparing whether populations with histories of strong versus weak sexual selection purge mutation load and resist extinction differently. After evolving replicate populations of the flour beetle Tribolium castaneum for 6 to 7 years under conditions that differed solely in the strengths of sexual selection, we revealed mutation load using inbreeding. Lineages from populations that had previously experienced strong sexual selection were resilient to extinction and maintained fitness under inbreeding, with some families continuing to survive after 20 generations of sib × sib mating. By contrast, lineages derived from populations that experienced weak or non-existent sexual selection showed rapid fitness declines under inbreeding, and all were extinct after generation 10. Multiple mutations across the genome with individually small effects can be difficult to clear, yet sum to a significant fitness load; our findings reveal that sexual selection reduces this load, improving population viability in the face of genetic stress.

Peridural torácica alta associada ou não à peridural torácica baixa em pacientes ambulatoriais: implicações clínicas Peridural torácica alta asociada o no a la peridural torácica baja en pacientes ambulatoriales: implicaciones clínicas High thoracic epidural anesthesia associated or not to low thoracic epidural anesthesia in outpatient procedures: clinical implications

Directory of Open Access Journals (Sweden)

Djalma Sperhacke

2004-08-01

Full Text Available JUSTIFICATIVA E OBJETIVOS: Sob bloqueio peridural torácico baixo ou médio, as alterações hemodinâmicas são facilmente controladas. Como o bloqueio peridural torácico alto (T2-T3 acomete, freqüentemente, as raízes do plexo braquial (C4C5-T1(T2, algumas destas responsáveis pela formação do nervo frênico (C3-C4-C5 é de se supor, possíveis repercussões motoras deste último. O presente estudo realizado em cirurgias estéticas, sob bloqueio peridural segmentar isolado em T2-T3 ou associado ao bloqueio peridural segmentar em T11-T12, avaliou as repercussões motoras na dinâmica respiratória assim como nos membros superiores e inferiores. MÉTODO: Trinta e duas pacientes, estado físico ASA I e II, sem doença pulmonar broncoespástica, em atividade e peso corporal igual ou superior a 50 kg, foram submetidas a 21 bloqueios peridurais torácicos isolados em T2-T3 e as 11 restantes, a bloqueios combinados em T11-T12, com ropivacaína a 7,5% (45 a 90 mg associada ao sufentanil (10 a 20 µg. Repercussões hemodinâmicas, respiratórias e motoras nos membros superiores e inferiores foram avaliadas respectivamente, sob monitorização não-invasiva, espirometria, força de preensão da mão e escala de Bromage. RESULTADOS: A média de duração das cirurgias mamárias foi de 105 minutos com depressão motora dos membros superiores (p JUSTIFICATIVA Y OBJETIVOS: Sobre bloqueo peridural torácico bajo o medio, las alteraciones hemodinâmicas son fácilmente controladas. Como el bloqueo peridural torácico alto (T2-T3 acomete, frecuentemente, las raíces del plexo braquial (C4C5-T1(T2, algunas de estas responsables por la formación del nervio frénico (C3-C4-C5 es de suponer, posibles repercusiones motoras de este último. El presente estudio realizado en cirugías estéticas, sobre bloqueo peridural segmentar aislado en T2-T3 o asociado al bloqueo peridural segmentar en T11-T12, evaluó las repercusiones motoras en la dinámica respiratoria

Effects of Mode of Target Task Selection on Learning about Plants in a Mobile Learning Environment: Effortful Manual Selection versus Effortless QR-Code Selection

Science.gov (United States)

Gao, Yuan; Liu, Tzu-Chien; Paas, Fred

2016-01-01

This study compared the effects of effortless selection of target plants using quick respond (QR) code technology to effortful manual search and selection of target plants on learning about plants in a mobile device supported learning environment. In addition, it was investigated whether the effectiveness of the 2 selection methods was…

CuO-PANI nanostructure with tunable spectral selectivity for solar selective coating application

Energy Technology Data Exchange (ETDEWEB)

Cindrella, L., E-mail: cind@nitt.edu; Prabhu, S., E-mail: sprabhuk@gmail.com

2016-08-15

Highlights: • CuO-PANI nanostructure has been reported as the solar selective absorber coating. • Solar selectivity and efficiency of the coatings have been evaluated. • PANI provides a surface texture favourable for multiple reflection. - Abstract: CuO-PANI nanostructure has been demonstrated as the solar selective absorber coating for the first time. The effortless chemical methods and easily scalable techniques such as precipitation, in-situ polymerization and spray coating were adopted for the fabrication of CuO nanorods and CuO-PANI nanostructures for solar application. The synthesis was carried out without using any template. The morphology and phase structure of fabricated CuO nanorods and CuO-PANI nanostructure coatings were studied by atomic force microscopy, scanning electron microscopy and X-ray diffraction analysis. The energy dispersive X-ray spectra and elemental mapping confirm the presence of the chosen elements in the nanostructure. The solar absorptance (α{sub s}), thermal emittance (ε{sub t}) and selectivity (ξ) of the nanostructure coatings on glass substrate were optimized to 0.94, 0.01 and 94 respectively by changing the polyaniline content on the surface of the CuO nanorods. The efficiency of the solar selective coatings were evaluated. The optimized solar absorber coating of CuO-PANI nanostructure is highly promising for its selective optical properties.

”Pigen der ikke ville dø” - starten på en krise

OpenAIRE

Bonde, Anders; Nannberg, Niklas Schlippe

2013-01-01

The project aims to determine how Århus Universitetshospital and the consultant have handled the crisis related to the documentary called ”Pigen der ikke ville dø” and to evaluate eventual improvements. A focus group, a press release and several articles are the empirical data, which we analyse by the means of W. Timothy Coombs and William L. Benoit’s theories of crisis communication. The former deals with the strategic aspect of the field and the latter with the rhetorical. Finally we compar...

Distinct modulation of allergic T cell responses by subcutaneous versus sublingual allergen-specific immunotherapy

DEFF Research Database (Denmark)

Schulten, Véronique; Tripple, Victoria; Andersen, Kristian Aasbjerg

2016-01-01

mechanisms involved have not been fully explored. OBJECTIVE: To compare changes in the allergen-specific T cell response induced by subcutaneous versus sublingual administration of allergen-specific immunotherapy (AIT). METHODS: Grass pollen allergic patients were randomized into groups receiving either SCIT...... injections, or SLIT tablets or neither. PBMC were tested for Timothy grass (TG)-specific cytokine production by ELISPOT after in vitro expansion with TG peptide pools. Phenotypic characterization of cytokine producing cells was performed by FACS. RESULTS: In the SCIT group, decreased IL-5 production...

Index Selection in Relational Databases

NARCIS (Netherlands)

Choenni, R.S.; Blanken, Henk; Chang, S.C.

Intending to develop a tool which aims to support the physical design of relational databases can not be done without considering the problem of index selection. Generally the problem is split into a primary and secondary index selection problem and the selection is done per table. Whereas much

Beef Cattle: Selection and Evaluation.

Science.gov (United States)

Clemson Univ., SC. Vocational Education Media Center.

Designed for secondary vocational agriculture students, this text provides an overview of selecting and evaluating beef cattle in Future Farmers of America livestock judging events. The first of four major sections addresses topics such as the ideal beef animal, selecting steers, selecting breeding animals, studying the animal systematically, and…

5 CFR 330.1204 - Selection.

Science.gov (United States)

2010-01-01

... Employees § 330.1204 Selection. (a) If two or more individuals apply for a vacancy and the hiring agency... agency (under appropriate selection procedures, then: (3) Current or former Federal employees displaced... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Selection. 330.1204 Section 330.1204...

The effects of predictor method factors on selection outcomes: A modular approach to personnel selection procedures.

Science.gov (United States)

Lievens, Filip; Sackett, Paul R

2017-01-01

Past reviews and meta-analyses typically conceptualized and examined selection procedures as holistic entities. We draw on the product design literature to propose a modular approach as a complementary perspective to conceptualizing selection procedures. A modular approach means that a product is broken down into its key underlying components. Therefore, we start by presenting a modular framework that identifies the important measurement components of selection procedures. Next, we adopt this modular lens for reviewing the available evidence regarding each of these components in terms of affecting validity, subgroup differences, and applicant perceptions, as well as for identifying new research directions. As a complement to the historical focus on holistic selection procedures, we posit that the theoretical contributions of a modular approach include improved insight into the isolated workings of the different components underlying selection procedures and greater theoretical connectivity among different selection procedures and their literatures. We also outline how organizations can put a modular approach into operation to increase the variety in selection procedures and to enhance the flexibility in designing them. Overall, we believe that a modular perspective on selection procedures will provide the impetus for programmatic and theory-driven research on the different measurement components of selection procedures. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Lines of Descent Under Selection

Science.gov (United States)

Baake, Ellen; Wakolbinger, Anton

2017-11-01

We review recent progress on ancestral processes related to mutation-selection models, both in the deterministic and the stochastic setting. We mainly rely on two concepts, namely, the killed ancestral selection graph and the pruned lookdown ancestral selection graph. The killed ancestral selection graph gives a representation of the type of a random individual from a stationary population, based upon the individual's potential ancestry back until the mutations that define the individual's type. The pruned lookdown ancestral selection graph allows one to trace the ancestry of individuals from a stationary distribution back into the distant past, thus leading to the stationary distribution of ancestral types. We illustrate the results by applying them to a prototype model for the error threshold phenomenon.

Selecting for memory? The influence of selective attention on the mnemonic binding of contextual information.

Science.gov (United States)

Uncapher, Melina R; Rugg, Michael D

2009-06-24

Not all of what is experienced is remembered later. Behavioral evidence suggests that the manner in which an event is processed influences which aspects of the event will later be remembered. The present experiment investigated the neural correlates of "selective encoding," or the mechanisms that support the encoding of some elements of an event in preference to others. Event-related MRI data were acquired while volunteers selectively attended to one of two different contextual features of study items (color or location). A surprise memory test for the items and both contextual features was subsequently administered to determine the influence of selective attention on the neural correlates of contextual encoding. Activity in several cortical regions indexed later memory success selectively for color or location information, and this encoding-related activity was enhanced by selective attention to the relevant feature. Critically, a region in the hippocampus responded selectively to attended source information (whether color or location), demonstrating encoding-related activity for attended but not for nonattended source features. Together, the findings suggest that selective attention modulates the magnitude of activity in cortical regions engaged by different aspects of an event, and hippocampal encoding mechanisms seem to be sensitive to this modulation. Thus, the information that is encoded into a memory representation is biased by selective attention, and this bias is mediated by cortical-hippocampal interactions.

Selecting for memory? The influence of selective attention on the mnemonic binding of contextual information

Science.gov (United States)

Uncapher, Melina R.; Rugg, Michael D.

2009-01-01

Not all of what is experienced is remembered later. Behavioral evidence suggests that the manner in which an event is processed influences which aspects of the event will later be remembered. The present experiment investigated the neural correlates of ‘selective encoding’, or the mechanisms that support the encoding of some elements of an event in preference to others. Event-related functional magnetic resonance imaging (fMRI) data were acquired while volunteers selectively attended to one of two different contextual features of study items (color or location). A surprise memory test for the items and both contextual features was subsequently administered to determine the influence of selective attention on the neural correlates of contextual encoding. Activity in several cortical regions indexed later memory success selectively for color or location information, and this encoding-related activity was enhanced by selective attention to the relevant feature. Critically, a region in the hippocampus responded selectively to attended source information (whether color or location), demonstrating encoding-related activity for attended but not for nonattended source features. Together, the findings suggest that selective attention modulates the magnitude of activity in cortical regions engaged by different aspects of an event, and hippocampal encoding mechanisms seem to be sensitive to this modulation. Thus, the information that is encoded into a memory representation is biased by selective attention, and this bias is mediated by cortico-hippocampal interactions. PMID:19553466

Selection of Celebrity Endorsers

DEFF Research Database (Denmark)

Hollensen, Svend; Schimmelpfennig, Christian

2013-01-01

several candidates by means of subtle evaluation procedures. Design/methodology/approach – A case study research has been carried out among companies experienced in celebrity endorsements to learn more about the endorser selection process in practise. Based on these cases theory is inductively developed......Purpose - This research aims at shedding some light on the various avenues marketers can undertake until finally an endorsement contract is signed. The focus of the study lies on verifying the generally held assumption that endorser selection is usually taken care of by creative agencies, vetting....... Findings – Our research suggests that generally held assumption that endorsers being selected and thoroughly vetted by a creative agency may not be universally valid. A normative model to illustrate the continuum of the selection process in practise is suggested and the two polar case studies (Swiss brand...

Statistical selection : a way of thinking !

NARCIS (Netherlands)

Laan, van der P.; Aarts, E.H.L.; Eikelder, ten H.M.M.; Hemerik, C.; Rem, M.

1995-01-01

Statistical selection of the best population is discussed in general terms and the principles of statistical selection procedures are presented. Advantages and disadvantages of Subset Selection, one of the main approaches, are indicated. The selection of an almost best population is considered and

Statistical selection : a way of thinking!

NARCIS (Netherlands)

Laan, van der P.

1995-01-01

Statistical selection of the best population is discussed in general terms and the principles of statistical selection procedures are presented. Advantages and disadvantages of Subset Selection, one of the main approaches, are indicated. The selection of an almost best population is considered and

Extrapolating Weak Selection in Evolutionary Games

Science.gov (United States)

Wu, Bin; García, Julián; Hauert, Christoph; Traulsen, Arne

2013-01-01

In evolutionary games, reproductive success is determined by payoffs. Weak selection means that even large differences in game outcomes translate into small fitness differences. Many results have been derived using weak selection approximations, in which perturbation analysis facilitates the derivation of analytical results. Here, we ask whether results derived under weak selection are also qualitatively valid for intermediate and strong selection. By “qualitatively valid” we mean that the ranking of strategies induced by an evolutionary process does not change when the intensity of selection increases. For two-strategy games, we show that the ranking obtained under weak selection cannot be carried over to higher selection intensity if the number of players exceeds two. For games with three (or more) strategies, previous examples for multiplayer games have shown that the ranking of strategies can change with the intensity of selection. In particular, rank changes imply that the most abundant strategy at one intensity of selection can become the least abundant for another. We show that this applies already to pairwise interactions for a broad class of evolutionary processes. Even when both weak and strong selection limits lead to consistent predictions, rank changes can occur for intermediate intensities of selection. To analyze how common such games are, we show numerically that for randomly drawn two-player games with three or more strategies, rank changes frequently occur and their likelihood increases rapidly with the number of strategies . In particular, rank changes are almost certain for , which jeopardizes the predictive power of results derived for weak selection. PMID:24339769

Materials selection in mechanical design

International Nuclear Information System (INIS)

Ashby, M.F.; Cebon, D.

1993-01-01

A novel materials-selection procedure has been developed and implemented in software. The procedure makes use of Materials Selection Charts: a new way of displaying material property data; and performance indices: combinations of material properties which govern performance. Optimisation methods are employed for simultaneous selection of both material and shape. (orig.)

Materials selection in mechanical design

OpenAIRE

Ashby , M.; Cebon , D.

1993-01-01

A novel materials-selection procedure has been developed and implemented in software. The procedure makes use of Materials Selection Charts: a new way of displaying material property data; and performance indices: combinations of material properties which govern performance. Optimisation methods are employed for simultaneous selection of both material and shape.

Sex selection: treating different cases differently.

Science.gov (United States)

Dickens, B M; Serour, G I; Cook, R J; Qiu, R-Z

2005-08-01

This paper contrasts ethical approaches to sex selection in countries where discrimination against women is pervasive, resulting in selection against girl children, and in countries where there is less general discrimination and couples do not prefer children of either sex. National sex ratio imbalances where discrimination against women is common have resulted in laws and policies, such as in India and China, to deter and prevent sex selection. Birth ratios of children can be affected by techniques of prenatal sex determination and abortion, preconception sex selection and discarding disfavored embryos, and prefertilization sperm sorting, when disfavored sperm remain unused. Incentives for son preference are reviewed, and laws and policies to prevent sex selection are explained. The elimination of social, economic and other discrimination against women is urged to redress sex selection against girl children. Where there is no general selection against girl children, sex selection can be allowed to assist families that want children of both sexes.

Natural Selection in the Great Apes.

Science.gov (United States)

Cagan, Alexander; Theunert, Christoph; Laayouni, Hafid; Santpere, Gabriel; Pybus, Marc; Casals, Ferran; Prüfer, Kay; Navarro, Arcadi; Marques-Bonet, Tomas; Bertranpetit, Jaume; Andrés, Aida M

2016-12-01

Natural selection is crucial for the adaptation of populations to their environments. Here, we present the first global study of natural selection in the Hominidae (humans and great apes) based on genome-wide information from population samples representing all extant species (including most subspecies). Combining several neutrality tests we create a multi-species map of signatures of natural selection covering all major types of natural selection. We find that the estimated efficiency of both purifying and positive selection varies between species and is significantly correlated with their long-term effective population size. Thus, even the modest differences in population size among the closely related Hominidae lineages have resulted in differences in their ability to remove deleterious alleles and to adapt to changing environments. Most signatures of balancing and positive selection are species-specific, with signatures of balancing selection more often being shared among species. We also identify loci with evidence of positive selection across several lineages. Notably, we detect signatures of positive selection in several genes related to brain function, anatomy, diet and immune processes. Our results contribute to a better understanding of human evolution by putting the evidence of natural selection in humans within its larger evolutionary context. The global map of natural selection in our closest living relatives is available as an interactive browser at http://tinyurl.com/nf8qmzh. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Selection on Optimal Haploid Value Increases Genetic Gain and Preserves More Genetic Diversity Relative to Genomic Selection.

Science.gov (United States)

Daetwyler, Hans D; Hayden, Matthew J; Spangenberg, German C; Hayes, Ben J

2015-08-01

Doubled haploids are routinely created and phenotypically selected in plant breeding programs to accelerate the breeding cycle. Genomic selection, which makes use of both phenotypes and genotypes, has been shown to further improve genetic gain through prediction of performance before or without phenotypic characterization of novel germplasm. Additional opportunities exist to combine genomic prediction methods with the creation of doubled haploids. Here we propose an extension to genomic selection, optimal haploid value (OHV) selection, which predicts the best doubled haploid that can be produced from a segregating plant. This method focuses selection on the haplotype and optimizes the breeding program toward its end goal of generating an elite fixed line. We rigorously tested OHV selection breeding programs, using computer simulation, and show that it results in up to 0.6 standard deviations more genetic gain than genomic selection. At the same time, OHV selection preserved a substantially greater amount of genetic diversity in the population than genomic selection, which is important to achieve long-term genetic gain in breeding populations. Copyright © 2015 by the Genetics Society of America.

Parameters selection in gene selection using Gaussian kernel support vector machines by genetic algorithm

Institute of Scientific and Technical Information of China (English)

无

2005-01-01

In microarray-based cancer classification, gene selection is an important issue owing to the large number of variables and small number of samples as well as its non-linearity. It is difficult to get satisfying results by using conventional linear statistical methods. Recursive feature elimination based on support vector machine (SVM RFE) is an effective algorithm for gene selection and cancer classification, which are integrated into a consistent framework. In this paper, we propose a new method to select parameters of the aforementioned algorithm implemented with Gaussian kernel SVMs as better alternatives to the common practice of selecting the apparently best parameters by using a genetic algorithm to search for a couple of optimal parameter. Fast implementation issues for this method are also discussed for pragmatic reasons. The proposed method was tested on two representative hereditary breast cancer and acute leukaemia datasets. The experimental results indicate that the proposed method performs well in selecting genes and achieves high classification accuracies with these genes.

45 CFR 1305.6 - Selection process.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Selection process. 1305.6 Section 1305.6 Public... PROGRAM ELIGIBILITY, RECRUITMENT, SELECTION, ENROLLMENT AND ATTENDANCE IN HEAD START § 1305.6 Selection process. (a) Each Head Start program must have a formal process for establishing selection criteria and...

[Dental implant restoration abutment selection].

Science.gov (United States)

Bin, Shi; Hao, Zeng

2017-04-01

An increasing number of implant restoration abutment types are produced with the rapid development of dental implantology. Although various abutments can meet different clinical demands, the selection of the appropriate abutment is both difficult and confusing. This article aims to help clinicians select the appropriate abutment by describing abutment design, types, and selection criteria.

Selective attention without a neocortex.

Science.gov (United States)

Krauzlis, Richard J; Bogadhi, Amarender R; Herman, James P; Bollimunta, Anil

2018-05-01

Selective attention refers to the ability to restrict neural processing and behavioral responses to a relevant subset of available stimuli, while simultaneously excluding other valid stimuli from consideration. In primates and other mammals, descriptions of this ability typically emphasize the neural processing that takes place in the cerebral neocortex. However, non-mammals such as birds, reptiles, amphibians and fish, which completely lack a neocortex, also have the ability to selectively attend. In this article, we survey the behavioral evidence for selective attention in non-mammals, and review the midbrain and forebrain structures that are responsible. The ancestral forms of selective attention are presumably selective orienting behaviors, such as prey-catching and predator avoidance. These behaviors depend critically on a set of subcortical structures, including the optic tectum (OT), thalamus and striatum, that are highly conserved across vertebrate evolution. In contrast, the contributions of different pallial regions in the forebrain to selective attention have been subject to more substantial changes and reorganization. This evolutionary perspective makes plain that selective attention is not a function achieved de novo with the emergence of the neocortex, but instead is implemented by circuits accrued and modified over hundreds of millions of years, beginning well before the forebrain contained a neocortex. Determining how older subcortical circuits interact with the more recently evolved components in the neocortex will likely be crucial for understanding the complex properties of selective attention in primates and other mammals, and for identifying the etiology of attention disorders. Published by Elsevier Ltd.

Women: A Select Bibliography.

Science.gov (United States)

Kusnerz, Peggy A., Comp.; Pollack, Ann M., Comp.

This select bibliography lists books, monographs, journals and newsletters which relate to feminism, women's studies, and other perspectives on women. Selections are organized by topic: general, bibliographies, art and literature, biography/autobiography, economics, education, family and marriage, history, politics and sex roles. Also included is…

Kin Selection - Mutation Balance

DEFF Research Database (Denmark)

Dyken, J. David Van; Linksvayer, Timothy Arnold; Wade, Michael J.

2011-01-01

selection-mutation balance, which provides an evolutionary null hypothesis for the statics and dynamics of cheating. When social interactions have linear fitness effects and Hamilton´s rule is satisfied, selection is never strong enough to eliminate recurrent cheater mutants from a population, but cheater...

Protein structure and ionic selectivity in calcium channels: selectivity filter size, not shape, matters.

Science.gov (United States)

Malasics, Attila; Gillespie, Dirk; Nonner, Wolfgang; Henderson, Douglas; Eisenberg, Bob; Boda, Dezso

2009-12-01

Calcium channels have highly charged selectivity filters (4 COO(-) groups) that attract cations in to balance this charge and minimize free energy, forcing the cations (Na(+) and Ca(2+)) to compete for space in the filter. A reduced model was developed to better understand the mechanism of ion selectivity in calcium channels. The charge/space competition (CSC) mechanism implies that Ca(2+) is more efficient in balancing the charge of the filter because it provides twice the charge as Na(+) while occupying the same space. The CSC mechanism further implies that the main determinant of Ca(2+) versus Na(+) selectivity is the density of charged particles in the selectivity filter, i.e., the volume of the filter (after fixing the number of charged groups in the filter). In this paper we test this hypothesis by changing filter length and/or radius (shape) of the cylindrical selectivity filter of our reduced model. We show that varying volume and shape together has substantially stronger effects than varying shape alone with volume fixed. Our simulations show the importance of depletion zones of ions in determining channel conductance calculated with the integrated Nernst-Planck equation. We show that confining the protein side chains with soft or hard walls does not influence selectivity.

Attentional Selection of Feature Conjunctions Is Accomplished by Parallel and Independent Selection of Single Features.

Science.gov (United States)

Andersen, Søren K; Müller, Matthias M; Hillyard, Steven A

2015-07-08

Experiments that study feature-based attention have often examined situations in which selection is based on a single feature (e.g., the color red). However, in more complex situations relevant stimuli may not be set apart from other stimuli by a single defining property but by a specific combination of features. Here, we examined sustained attentional selection of stimuli defined by conjunctions of color and orientation. Human observers attended to one out of four concurrently presented superimposed fields of randomly moving horizontal or vertical bars of red or blue color to detect brief intervals of coherent motion. Selective stimulus processing in early visual cortex was assessed by recordings of steady-state visual evoked potentials (SSVEPs) elicited by each of the flickering fields of stimuli. We directly contrasted attentional selection of single features and feature conjunctions and found that SSVEP amplitudes on conditions in which selection was based on a single feature only (color or orientation) exactly predicted the magnitude of attentional enhancement of SSVEPs when attending to a conjunction of both features. Furthermore, enhanced SSVEP amplitudes elicited by attended stimuli were accompanied by equivalent reductions of SSVEP amplitudes elicited by unattended stimuli in all cases. We conclude that attentional selection of a feature-conjunction stimulus is accomplished by the parallel and independent facilitation of its constituent feature dimensions in early visual cortex. The ability to perceive the world is limited by the brain's processing capacity. Attention affords adaptive behavior by selectively prioritizing processing of relevant stimuli based on their features (location, color, orientation, etc.). We found that attentional mechanisms for selection of different features belonging to the same object operate independently and in parallel: concurrent attentional selection of two stimulus features is simply the sum of attending to each of those

Maternal allergic disease does not affect the phenotype of T and B cells or the immune response to allergens in neonates.

Science.gov (United States)

Rindsjö, E; Joerink, M; Johansson, C; Bremme, K; Malmström, V; Scheynius, A

2010-07-01

It is hypothesized that the in utero environment in allergic mothers can affect the neonatal immune responses. The aim of this study was to analyse the effect of maternal allergic disease on cord blood mononuclear cell (CBMC) phenotype and proliferative responses upon allergen stimulation. Peripheral blood mononuclear cells (PBMC) from 12 allergic and 14 nonallergic mothers and CBMC from their children were analysed. In the mothers, we determined cell proliferation, production of IL-4 and expression of FOXP3 in response to allergen stimulation. In the children, we evaluated cell proliferation and FOXP3 expression following allergen stimulation. Furthermore, expression of different homing markers on T cells and regulatory T cells and maturity of the T cells and B cell subsets were evaluated directly ex vivo. The timothy- and birch-allergic mothers responded with increased proliferation and/or IL-4 production towards timothy and birch extract, respectively, when compared to nonallergic mothers. This could not be explained by impairment of FOXP3(+) regulatory T cells in the allergic mothers. CBMC proliferation and FOXP3 expression in response to allergens were not affected by the allergic status of the mother. Also, phenotype of T cells, FOXP3(+) regulatory T cells and B cells was not affected by the allergic status of the mother. Our results suggest that maternal allergic disease has no effect on the neonatal response to allergens or the phenotype of neonatal lymphocytes. The factors studied here could, however, still affect later development of allergy.

Pollen-Associated Microbiome Correlates with Pollution Parameters and the Allergenicity of Pollen.

Directory of Open Access Journals (Sweden)

Andrea Obersteiner

Full Text Available Pollen allergies have been rapidly increasing over the last decades. Many allergenic proteins and non-allergenic adjuvant compounds of pollen are involved in the plant defense against environmental or microbial stress. The first aim of this study was to analyze and compare the colonizing microbes on allergenic pollen. The second aim was to investigate detectable correlations between pollen microbiota and parameters of air pollution or pollen allergenicity. To reach these aims, bacterial and fungal DNA was isolated from pollen samples of timothy grass (Phleum pratense, n = 20 and birch trees (Betula pendula, n = 55. With this isolated DNA, a terminal restriction fragment length polymorphism analysis was performed. One result was that the microbial diversity on birch tree and timothy grass pollen samples (Shannon/Simpson diversity indices was partly significantly correlated to allergenicity parameters (Bet v 1/Phl p 5, pollen-associated lipid mediators. Furthermore, the microbial diversity on birch pollen samples was correlated to on-site air pollution (nitrogen dioxide (NO2, ammonia (NH3, and ozone (O3. What is more, a significant negative correlation was observed between the microbial diversity on birch pollen and the measured NO2 concentrations on the corresponding trees. Our results showed that the microbial composition of pollen was correlated to environmental exposure parameters alongside with a differential expression of allergen and pollen-associated lipid mediators. This might translate into altered allergenicity of pollen due to environmental and microbial stress.

Benchmarking Variable Selection in QSAR.

Science.gov (United States)

Eklund, Martin; Norinder, Ulf; Boyer, Scott; Carlsson, Lars

2012-02-01

Variable selection is important in QSAR modeling since it can improve model performance and transparency, as well as reduce the computational cost of model fitting and predictions. Which variable selection methods that perform well in QSAR settings is largely unknown. To address this question we, in a total of 1728 benchmarking experiments, rigorously investigated how eight variable selection methods affect the predictive performance and transparency of random forest models fitted to seven QSAR datasets covering different endpoints, descriptors sets, types of response variables, and number of chemical compounds. The results show that univariate variable selection methods are suboptimal and that the number of variables in the benchmarked datasets can be reduced with about 60 % without significant loss in model performance when using multivariate adaptive regression splines MARS and forward selection. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Variable Selection via Partial Correlation.

Science.gov (United States)

Li, Runze; Liu, Jingyuan; Lou, Lejia

2017-07-01

Partial correlation based variable selection method was proposed for normal linear regression models by Bühlmann, Kalisch and Maathuis (2010) as a comparable alternative method to regularization methods for variable selection. This paper addresses two important issues related to partial correlation based variable selection method: (a) whether this method is sensitive to normality assumption, and (b) whether this method is valid when the dimension of predictor increases in an exponential rate of the sample size. To address issue (a), we systematically study this method for elliptical linear regression models. Our finding indicates that the original proposal may lead to inferior performance when the marginal kurtosis of predictor is not close to that of normal distribution. Our simulation results further confirm this finding. To ensure the superior performance of partial correlation based variable selection procedure, we propose a thresholded partial correlation (TPC) approach to select significant variables in linear regression models. We establish the selection consistency of the TPC in the presence of ultrahigh dimensional predictors. Since the TPC procedure includes the original proposal as a special case, our theoretical results address the issue (b) directly. As a by-product, the sure screening property of the first step of TPC was obtained. The numerical examples also illustrate that the TPC is competitively comparable to the commonly-used regularization methods for variable selection.

Contemporary views on selective mutism

Directory of Open Access Journals (Sweden)

Dimoski Sanja

2016-01-01

Full Text Available The aim of this paper is to review contemporary literature on selective mutism (SM, available in our language. The paper includes a contemporary definition of the disorder, previous studies of selective mutism, theories about its origin, and treatment. SM is a disorder that occurs in childhood, when a child's speech is selectively lacking in certain social situations. School is the context in which the disorder is typically manifested, which is why SM is often diagnosed only after children start school. The paper gives a historical account of changes in views on this disorder. Modern conceptions emphasize selective inability of children to spontaneously and successfully express themselves verbally. In researching SM, case studies on children who have selective mutism are most commonly published. Etiological factors are not precisely defined, and different conceptions give their interpretations depending on various theoretical frameworks. Some studies consistently indicate a relation between SM and social anxiety, and some with opposing behavior and delays in language development. Based on theoretical explanations of SM, psychological interventions (behavioral and cognitive-behavioral, psychodynamic and projective techniques, counseling and family therapy are created. Modern treatment of selective mutism includes an eclectic approach and emphasizes the role of teachers and school in general. Future studies should deepen the knowledge about selective mutism, specify the methodological procedure and stimulate the individualized treatment of children with SM.

Sexual selection in Fungi

NARCIS (Netherlands)

Nieuwenhuis, B.P.S.

2012-01-01

Sexual selection is an important factor that drives evolution, in which fitness is increased, not by increasing survival or viability, but by acquiring more or better mates. Sexual selection favours traits that increase the ability of an individual to obtain more matings than other individuals

A Selective CPS Transformation

DEFF Research Database (Denmark)

Nielsen, Lasse Riechstein

2001-01-01

characterize this involvement as a control effect and we present a selective CPS transformation that makes functions and expressions continuation-passing if they have a control effect, and that leaves the rest of the program in direct style. We formalize this selective CPS transformation with an operational...

Variable selectivity and the role of nutritional quality in food selection by a planktonic rotifer

International Nuclear Information System (INIS)

Sierszen, M.E.

1990-01-01

To investigate the potential for selective feeding to enhance fitness, I test the hypothesis that an herbivorous zooplankter selects those food items that best support its reproduction. Under this hypothesis, growth and reproduction on selected food items should be higher than on less preferred items. The hypothesis is not supported. In situ selectivity by the rotifer Keratella taurocephala for Cryptomonas relative to Chlamydomonas goes through a seasonal cycle, in apparent response to fluctuating Cryptomonas populations. However, reproduction on a unialgal diet of Cryptomonas is consistently high and similar to that on Chlamydomonas. Oocystis, which also supports reproduction equivalent to that supported by Chlamydomonas, is sometimes rejected by K. taurocephala. In addition, K. taurocephala does not discriminate between Merismopedia and Chlamydomonas even though Merismopedia supports virtually no reproduction by the rotifer. Selection by K. taurocephala does not simply maximize the intake of food items that yield high reproduction. Selectivity is a complex, dynamic process, one function of which may be the exploitation of locally or seasonally abundant foods. (author)

Selective vulnerability in brain hypoxia

DEFF Research Database (Denmark)

Cervos-Navarro, J.; Diemer, Nils Henrik

1991-01-01

Neuropathology, selective vulnerability, brain hypoxia, vascular factors, excitotoxicity, ion homeostasis......Neuropathology, selective vulnerability, brain hypoxia, vascular factors, excitotoxicity, ion homeostasis...

HARMONIC DRIVE SELECTION

Directory of Open Access Journals (Sweden)

Piotr FOLĘGA

2014-03-01

Full Text Available The variety of types and sizes currently in production harmonic drive is a problem in their rational choice. Properly selected harmonic drive must meet certain requirements during operation, and achieve the anticipated service life. The paper discusses the problems associated with the selection of the harmonic drive. It also presents the algorithm correct choice of harmonic drive. The main objective of this study was to develop a computer program that allows the correct choice of harmonic drive by developed algorithm.

A Heckman Selection- t Model

KAUST Repository

Marchenko, Yulia V.

2012-03-01

Sample selection arises often in practice as a result of the partial observability of the outcome of interest in a study. In the presence of sample selection, the observed data do not represent a random sample from the population, even after controlling for explanatory variables. That is, data are missing not at random. Thus, standard analysis using only complete cases will lead to biased results. Heckman introduced a sample selection model to analyze such data and proposed a full maximum likelihood estimation method under the assumption of normality. The method was criticized in the literature because of its sensitivity to the normality assumption. In practice, data, such as income or expenditure data, often violate the normality assumption because of heavier tails. We first establish a new link between sample selection models and recently studied families of extended skew-elliptical distributions. Then, this allows us to introduce a selection-t (SLt) model, which models the error distribution using a Student\\'s t distribution. We study its properties and investigate the finite-sample performance of the maximum likelihood estimators for this model. We compare the performance of the SLt model to the conventional Heckman selection-normal (SLN) model and apply it to analyze ambulatory expenditures. Unlike the SLNmodel, our analysis using the SLt model provides statistical evidence for the existence of sample selection bias in these data. We also investigate the performance of the test for sample selection bias based on the SLt model and compare it with the performances of several tests used with the SLN model. Our findings indicate that the latter tests can be misleading in the presence of heavy-tailed data. © 2012 American Statistical Association.

Selective-imaging camera

Science.gov (United States)

Szu, Harold; Hsu, Charles; Landa, Joseph; Cha, Jae H.; Krapels, Keith A.

2015-05-01

How can we design cameras that image selectively in Full Electro-Magnetic (FEM) spectra? Without selective imaging, we cannot use, for example, ordinary tourist cameras to see through fire, smoke, or other obscurants contributing to creating a Visually Degraded Environment (VDE). This paper addresses a possible new design of selective-imaging cameras at firmware level. The design is consistent with physics of the irreversible thermodynamics of Boltzmann's molecular entropy. It enables imaging in appropriate FEM spectra for sensing through the VDE, and displaying in color spectra for Human Visual System (HVS). We sense within the spectra the largest entropy value of obscurants such as fire, smoke, etc. Then we apply a smart firmware implementation of Blind Sources Separation (BSS) to separate all entropy sources associated with specific Kelvin temperatures. Finally, we recompose the scene using specific RGB colors constrained by the HVS, by up/down shifting Planck spectra at each pixel and time.

Factors of site selection for nuclear power plants in selected industrial states

International Nuclear Information System (INIS)

Hoffmann, L.; Obermair, G.; Ringler, W.; Romahn, B.; Sanders, H.

1978-01-01

The range of the tasks within the project consists of working out an optimal catalogue of criteria for the site selection for nuclear power plants; establishing a structured documentation system for the criteria and licensing procedures used by selected industrial countries when selecting sites for nuclear power plants; analyzing and evaluating the documented material with the aim of supplying the basis for decisions concerning land use. The tasks are being realized within a technological ring of data (for the period until 1990, reactor types, cooling, power-heat coupling, special sites, block sizes, local concentration) and a set politico-economical ring of data for the following countries: F.R. Germany, Belgium, Switzerland, Great Britain, Sweden, Denmark, Austria, France, Netherlands, USA, Japan, Yougoslavia. (HP) [de

E-recruitment and Selection

DEFF Research Database (Denmark)

Holm, Anna B.; Haahr, Lars

2018-01-01

The use of information and communication technologies has revolutionized e-recruitment and selection function in many organizations, especially transforming it into a time- and space-independent process of sourcing and evaluating candidates. In the process, organizations rely on websites, social...... media and job portals for sourcing candidates and deploy computerized and online assessment tools when selecting the best-qualified applicants. Similarly, their communication with jobseekers has moved to cyberspace and is often performed through applicant tracking systems, where hiring managers use...... mobile technologies to track and evaluate candidates. In this chapter, we present an overview of e-recruitment and selection practices and discuss the use of technology throughout the hiring process....

The spatial patterns of directional phenotypic selection.

Science.gov (United States)

Siepielski, Adam M; Gotanda, Kiyoko M; Morrissey, Michael B; Diamond, Sarah E; DiBattista, Joseph D; Carlson, Stephanie M

2013-11-01

Local adaptation, adaptive population divergence and speciation are often expected to result from populations evolving in response to spatial variation in selection. Yet, we lack a comprehensive understanding of the major features that characterise the spatial patterns of selection, namely the extent of variation among populations in the strength and direction of selection. Here, we analyse a data set of spatially replicated studies of directional phenotypic selection from natural populations. The data set includes 60 studies, consisting of 3937 estimates of selection across an average of five populations. We performed meta-analyses to explore features characterising spatial variation in directional selection. We found that selection tends to vary mainly in strength and less in direction among populations. Although differences in the direction of selection occur among populations they do so where selection is often weakest, which may limit the potential for ongoing adaptive population divergence. Overall, we also found that spatial variation in selection appears comparable to temporal (annual) variation in selection within populations; however, several deficiencies in available data currently complicate this comparison. We discuss future research needs to further advance our understanding of spatial variation in selection. © 2013 John Wiley & Sons Ltd/CNRS.

The spatial patterns of directional phenotypic selection

KAUST Repository

Siepielski, Adam M.

2013-09-12

Local adaptation, adaptive population divergence and speciation are often expected to result from populations evolving in response to spatial variation in selection. Yet, we lack a comprehensive understanding of the major features that characterise the spatial patterns of selection, namely the extent of variation among populations in the strength and direction of selection. Here, we analyse a data set of spatially replicated studies of directional phenotypic selection from natural populations. The data set includes 60 studies, consisting of 3937 estimates of selection across an average of five populations. We performed meta-analyses to explore features characterising spatial variation in directional selection. We found that selection tends to vary mainly in strength and less in direction among populations. Although differences in the direction of selection occur among populations they do so where selection is often weakest, which may limit the potential for ongoing adaptive population divergence. Overall, we also found that spatial variation in selection appears comparable to temporal (annual) variation in selection within populations; however, several deficiencies in available data currently complicate this comparison. We discuss future research needs to further advance our understanding of spatial variation in selection. © 2013 John Wiley & Sons Ltd/CNRS.

The fourth dimension

CERN Document Server

Rucker, Rudy

2014-01-01

""This is an invigorating book, a short but spirited slalom for the mind."" - Timothy Ferris, The New York Times Book Review ""Highly readable. One is reminded of the breadth and depth of Hofstadter's Gödel, Escher, Bach."" - Science""Anyone with even a minimal interest in mathematics and fantasy will find The Fourth Dimension informative and mind-dazzling... [Rucker] plunges into spaces above three with a zest and energy that is breathtaking."" - Martin Gardner ""Those who think the fourth dimension is nothing but time should be encouraged to read The Fourth Dimension, along with anyone else

α-Tocopherol and β-carotene contents of forage species in four-cut system

DEFF Research Database (Denmark)

Lindquist, H.; Nadeau, A.; Jensen, Søren Krogh

2014-01-01

α-Tocopherol and β-carotene concentrations were measured in herbage of birdsfoot trefoil (Bft), red clover (Rc), white clover (Wc), timothy (Ti) and perennial ryegrass (Pr) grown in four mixtures (Bft+Ti, Rc+Ti, Rc+Pr and Wc+Pr) in a small-plot field experiment at Foulum, Denmark, over 2 years. P......-carotene concentrations were 54 and 62 mg kg−1 DM. In conclusion, herbage of birdsfoot trefoil generally had higher vitamin concentrations than white or red clover, but differences between the two grass species were small and inconsistent....

Elwha River dam removal: A major opportunity for salmon and steelhead recolonization

Science.gov (United States)

Pess, George R.; Brenkman, Samuel J.; Winans, Gary A.; McHenry, Michael L.; Duda, Jeffrey J.; Beechie, Timothy J.

2010-01-01

In this in-depth paper, authors George R. Pess, Gary A. Winans and Timothy J. Beechie of the NOAA Fisheries, Northwest Fisheries Science Center in Seattle, Samuel J. Brenkman of the National Park Service, Olympic National Park, Michael L. McHenry of the Lower Elwha Klallam Tribe and Jeffrey J. Duda of the U.S. Geological Survey, Western Fisheries Research Center in Seattle, provide an historical overview of the Elwha River system, and its native anadromous fish runs and the prospect of their recolonization after the Elwha and Glines Canyon dams are removed.

Who would benefit from memory training? A pilot study examining the ceiling effect of concurrent cognitive stimulation

OpenAIRE

Kwok, Timothy CY; Chau, Wai Wang; Yuen, Kenneth SL; Wong, Anita YM; Li, Jessie CY; Shiu, Rebecca YY; Ho, Florence KY

2011-01-01

Timothy CY Kwok1,2, Wai Wang Chau1, Kenneth SL Yuen1,3, Anita YM Wong4, Jessie CY Li1, Rebecca YY Shiu4, Florence KY Ho11Jockey Club Centre for Positive Ageing, Hong Kong; 2Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong; 3Laboratory of Neuropsychology, Department of Psychology, University of Hong Kong, Pokfulam, Hong Kong; 4The Hong Kong Chinese Women's Club Madam Wong Chan Sook Ying Memorial Care and Attention Home for the Aged, Hong KongAbstr...

On Pauline Quotation Modes and Their Textual-Literary Value. A Brief Note On “2 Timothy”, 2, 19

Directory of Open Access Journals (Sweden)

Simone Turco

2018-06-01

Full Text Available In his passage 2 Timothy 2,19 Saint Paul quotes two passages – or, at least, so he says – from the Old Testament. Yet, while the first citation appears to be an almost verbatim quotation from Numbers 16, 5, the second does not refer to any specific passage. As such, it can be read as a summary of a variety of biblical passages. Philologists and exegetes ought to include this pastoral among Saint Paul’s authentic epistles, as it reflects his typical style and also suggests when, biographically, it was written.

Mechanism of the toxic action of sulfur dioxide on plants

Energy Technology Data Exchange (ETDEWEB)

Nikolaevskii, V S; Miroshnikova, A T; Firger, V V; Belokrylova, L M

1975-01-01

Experiments were performed to determine the effects of sulfur dioxide on U CO2 metabolism and photosynthesis in fescue and timothy grass and in maple and barberry branches. The free radical inhibitors, ascorbic acid and thiourea, were found to decrease the damaging effects of the sulfur dioxide. These results indicated that the processes involved are of the free-radical chain type. Even at low sulfur dioxide concentrations, photosphosphorylation and carbon dioxide assimilation were inhibited. In addition, starch and protein as well as the formation of polymeric substances were also inhibited.

The genetic basis of long QT and short QT syndromes: a mutation update

DEFF Research Database (Denmark)

Hedley, Paula L; Jørgensen, Poul; Schlamowitz, Sarah

2009-01-01

Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization abnormalities that are characterized by length perturbations of the QT interval as measured on electrocardiogram (ECG). Prolonged QT interval and a propensity for ventricular tachycardia of the torsades de pointes (TdP) type......-Nielsen syndrome (JLNS), Andersen syndrome (AS), and Timothy syndrome (TS). The genetics are further complicated by the occurrence of double and triple heterozygotes in LQTS and a considerable number of nonpathogenic rare polymorphisms in the involved genes. SQTS is a very rare condition, caused by mutations...

The (Impossibilit y of Time Travel: Haiti ’s Pre- and Post-Earthquake Futures

Directory of Open Access Journals (Sweden)

Landon Yarrington

2012-12-01

Full Text Available Review of:Travesty in Haiti: A True Account of Christian Missions, Orphanages, Fraud, Food Aid and Drug Trafficking [second edition]. Timothy T. Schwartz. Charleston SC: Booksurge, 2010. xlvii + 262 pp. (Paper US$ 15.99Haiti in the Balance: Why Foreign Aid Has Failed and What We Can Do About It. Terry Buss . Washington DC: Brookings Institute Press, 2008. xvi + 230 pp. (Paper US$ 28.95Backpacks Full of Hope: The UN Mission in Haiti. Eduardo Aldunate. Waterloo ON: Wilfrid Laurier University Press, 2010. xx + 230 pp. (Paper US$ 34.95

The 13th Psychological Operations Battalion (EPW) during Mobilization, Desert Shield / Desert Storm and Demobilization

Science.gov (United States)

1993-05-10

they did not sit, they squatted . They also had a great need for privacy. A modification was made, converting the latrines into a three-hole facility...BRYANT, Cedric SSG FELTON, Mark A. SSG MCQUAID, Daniel A. SSG NUCKLES, Bradley SSG TAYLOR, Ernest K JR SSG GAUL, Robert J. SGT CAIN, William T. SPC ...MCSHANE, Charles A. SPC THOMAS, Timothy L. SPC r Ii rP .I’., . .. ; :; ’, .; ., ., . ’I .If ’’ . Ill TL 5IL LLG •~ ,i:b F--,.,,. ’ 9 1 .... E8~ %F, 4

Changes in nutritive value and herbage yield during extended growth intervals in grass-legume mixtures

DEFF Research Database (Denmark)

Elgersma, Anjo; Søegaard, Karen

2018-01-01

. Perennial ryegrass was sown with each of four legumes: red clover, white clover, lucerne and birdsfoot trefoil, and white clover was sown with hybrid ryegrass, meadow fescue and timothy. Effects of species composition on herbage yield, contents of N, neutral detergent fibre (NDF), acid detergent fibre (ADF...... in quality parameters differed among species and functional groups, i.e., grasses and legumes. Results are discussed in the context of quantifying the impact of delaying the harvest date of grass–legume mixtures and relationships between productivity and components of feed quality....

The LIFE Cognition Study: design and baseline characteristics

OpenAIRE

Sink, Kaycee M; Espeland, Mark A; Rushing, Julia; Castro, Cynthia M; Church, Timothy S; Cohen, Ronald; Gill, Thomas M; Henkin, Leora; Jennings, Janine M; Kerwin, Diana R; Manini, Todd M; Myers, Valerie; Pahor, Marco; Reid, Kieran F; Woolard, Nancy

2014-01-01

Kaycee M Sink,1 Mark A Espeland,2 Julia Rushing,2 Cynthia M Castro,3 Timothy S Church,4 Ronald Cohen,5 Thomas M Gill,6 Leora Henkin,2 Janine M Jennings,7 Diana R Kerwin,8 Todd M Manini,5 Valerie Myers,9 Marco Pahor,5 Kieran F Reid,10 Nancy Woolard,1 Stephen R Rapp,11 Jeff D Williamson1 On behalf of LIFE Investigators 1Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of ...

Allowing Students to Select Deliverables for Peer Review: Analysis of a Free-Selection Protocol

DEFF Research Database (Denmark)

Papadopoulos, Pantelis M.; Lagkas, Thomas; Demetriadis, Stavros

2011-01-01

This study analyzes the benefits and limitations of a “free-selection” peer assignment protocol by comparing them to the widely implemented “assigned-pair” protocol. The primary motivation was to circumvent the issues that often appear to the instructors implementing peer review activities with pre......-Selection, where students were able to explore and select peer work for review. Result analysis showed a very strong tendency in favor of the Free-Selection students regarding both domain specific (conceptual) and domain-general (reviewing) knowledge....

Kin selection versus sexual selection: why the ends do not meet

DEFF Research Database (Denmark)

Boomsma, Jacobus J

2007-01-01

non-social and cooperative breeding. Sexually selected traits in eusocial lineages are therefore peculiar, and their evolution constrained. Indirect (inclusive) fitness benefits in cooperatively breeding vertebrates appear to be negatively correlated with promiscuity, corroborating that kin selection......I redevelop the hypothesis that lifetime monogamy is a fundamental condition for the evolution of eusocial lineages with permanent non-reproductive castes, and that later elaborations--such as multiply-mated queens and multi-queen colonies--arose without the re-mating promiscuity that characterizes...

Opportunistic Relay Selection With Limited Feedback

KAUST Repository

Eltayeb, Mohammed E.; Elkhalil, Khalil; Bahrami, Hamid Reza; Al-Naffouri, Tareq Y.

2015-01-01

Relay selection is a simple technique that achieves spatial diversity in cooperative relay networks. Generally, relay selection algorithms require channel state information (CSI) feedback from all cooperating relays to make a selection decision

Drug product selection: legal issues.

Science.gov (United States)

Christensen, T P; Kirking, D M; Ascione, F J; Welage, L S; Gaither, C A

2001-01-01

To review the potential legal liability of the pharmacist in the drug product selection process. Published articles identified through MEDLINE, published law reviews identified through InfoTrac, and appellate court decisions. Search terms used included pharmacist liability, drug product selection, and generic substitution. Additional articles, books, and appellate court decisions were identified from the bibliographies of retrieved articles and citations in appellate court decisions. Pharmacists engaging in drug product selection are civilly liable under three legal theories: negligence, express or implied warranties, and strict product liability. Potential criminal liability includes prosecution for insurance fraud, deceptive business practices, and violation of state drug product selection laws and regulation. Pharmacists increase their liability when engaging in drug product selection, but the increase is small. Still, the law continues to evolve as pharmacists seek expanded roles and responsibilities. When courts give closer examination to pharmacists' expanded role, it is likely that pharmacists' liability will increase.

SELECTING QUASARS BY THEIR INTRINSIC VARIABILITY

International Nuclear Information System (INIS)

Schmidt, Kasper B.; Rix, Hans-Walter; Jester, Sebastian; Hennawi, Joseph F.; Marshall, Philip J.; Dobler, Gregory

2010-01-01

We present a new and simple technique for selecting extensive, complete, and pure quasar samples, based on their intrinsic variability. We parameterize the single-band variability by a power-law model for the light-curve structure function, with amplitude A and power-law index γ. We show that quasars can be efficiently separated from other non-variable and variable sources by the location of the individual sources in the A-γ plane. We use ∼60 epochs of imaging data, taken over ∼5 years, from the SDSS stripe 82 (S82) survey, where extensive spectroscopy provides a reference sample of quasars, to demonstrate the power of variability as a quasar classifier in multi-epoch surveys. For UV-excess selected objects, variability performs just as well as the standard SDSS color selection, identifying quasars with a completeness of 90% and a purity of 95%. In the redshift range 2.5 < z < 3, where color selection is known to be problematic, variability can select quasars with a completeness of 90% and a purity of 96%. This is a factor of 5-10 times more pure than existing color selection of quasars in this redshift range. Selecting objects from a broad griz color box without u-band information, variability selection in S82 can afford completeness and purity of 92%, despite a factor of 30 more contaminants than quasars in the color-selected feeder sample. This confirms that the fraction of quasars hidden in the 'stellar locus' of color space is small. To test variability selection in the context of Pan-STARRS 1 (PS1) we created mock PS1 data by down-sampling the S82 data to just six epochs over 3 years. Even with this much sparser time sampling, variability is an encouragingly efficient classifier. For instance, a 92% pure and 44% complete quasar candidate sample is attainable from the above griz-selected catalog. Finally, we show that the presented A-γ technique, besides selecting clean and pure samples of quasars (which are stochastically varying objects), is also

Selective, electrochemical etching of a semiconductor

Science.gov (United States)

Dahal, Rajendra P.; Bhat, Ishwara B.; Chow, Tat-Sing

2018-03-20

Methods for facilitating fabricating semiconductor structures are provided which include: providing a multilayer structure including a semiconductor layer, the semiconductor layer including a dopant and having an increased conductivity; selectively increasing, using electrochemical processing, porosity of the semiconductor layer, at least in part, the selectively increasing porosity utilizing the increased conductivity of the semiconductor layer; and removing, at least in part, the semiconductor layer with the selectively increased porosity from the multilayer structure. By way of example, the selectively increasing porosity may include selectively, anodically oxidizing, at least in part, the semiconductor layer of the multilayer structure.

Innovation During the Supplier Selection Process

DEFF Research Database (Denmark)

Pilkington, Alan; Pedraza, Isabel

2014-01-01

Established ideas on supplier selection have not moved much from the original premise of how to choose between bidders. Whilst we have added many different tools and refinements to choose between alternative suppliers, its nature has not evolved. We move the original selection process approach...... observed through an ethnographic embedded researcher study has refined the selection process and has two selection stages one for first supply covering tool/process developed and another later for resupply of mature parts. We report the details of the process, those involved, the criteria employed...... and identify benefits and weaknesses of this enhanced selection process....

Natural selection promotes antigenic evolvability.

Science.gov (United States)

Graves, Christopher J; Ros, Vera I D; Stevenson, Brian; Sniegowski, Paul D; Brisson, Dustin

2013-01-01

The hypothesis that evolvability - the capacity to evolve by natural selection - is itself the object of natural selection is highly intriguing but remains controversial due in large part to a paucity of direct experimental evidence. The antigenic variation mechanisms of microbial pathogens provide an experimentally tractable system to test whether natural selection has favored mechanisms that increase evolvability. Many antigenic variation systems consist of paralogous unexpressed 'cassettes' that recombine into an expression site to rapidly alter the expressed protein. Importantly, the magnitude of antigenic change is a function of the genetic diversity among the unexpressed cassettes. Thus, evidence that selection favors among-cassette diversity is direct evidence that natural selection promotes antigenic evolvability. We used the Lyme disease bacterium, Borrelia burgdorferi, as a model to test the prediction that natural selection favors amino acid diversity among unexpressed vls cassettes and thereby promotes evolvability in a primary surface antigen, VlsE. The hypothesis that diversity among vls cassettes is favored by natural selection was supported in each B. burgdorferi strain analyzed using both classical (dN/dS ratios) and Bayesian population genetic analyses of genetic sequence data. This hypothesis was also supported by the conservation of highly mutable tandem-repeat structures across B. burgdorferi strains despite a near complete absence of sequence conservation. Diversification among vls cassettes due to natural selection and mutable repeat structures promotes long-term antigenic evolvability of VlsE. These findings provide a direct demonstration that molecular mechanisms that enhance evolvability of surface antigens are an evolutionary adaptation. The molecular evolutionary processes identified here can serve as a model for the evolution of antigenic evolvability in many pathogens which utilize similar strategies to establish chronic infections.

Natural selection promotes antigenic evolvability.

Directory of Open Access Journals (Sweden)

Christopher J Graves

Full Text Available The hypothesis that evolvability - the capacity to evolve by natural selection - is itself the object of natural selection is highly intriguing but remains controversial due in large part to a paucity of direct experimental evidence. The antigenic variation mechanisms of microbial pathogens provide an experimentally tractable system to test whether natural selection has favored mechanisms that increase evolvability. Many antigenic variation systems consist of paralogous unexpressed 'cassettes' that recombine into an expression site to rapidly alter the expressed protein. Importantly, the magnitude of antigenic change is a function of the genetic diversity among the unexpressed cassettes. Thus, evidence that selection favors among-cassette diversity is direct evidence that natural selection promotes antigenic evolvability. We used the Lyme disease bacterium, Borrelia burgdorferi, as a model to test the prediction that natural selection favors amino acid diversity among unexpressed vls cassettes and thereby promotes evolvability in a primary surface antigen, VlsE. The hypothesis that diversity among vls cassettes is favored by natural selection was supported in each B. burgdorferi strain analyzed using both classical (dN/dS ratios and Bayesian population genetic analyses of genetic sequence data. This hypothesis was also supported by the conservation of highly mutable tandem-repeat structures across B. burgdorferi strains despite a near complete absence of sequence conservation. Diversification among vls cassettes due to natural selection and mutable repeat structures promotes long-term antigenic evolvability of VlsE. These findings provide a direct demonstration that molecular mechanisms that enhance evolvability of surface antigens are an evolutionary adaptation. The molecular evolutionary processes identified here can serve as a model for the evolution of antigenic evolvability in many pathogens which utilize similar strategies to establish

Parental selection of children's sexual orientation.

Science.gov (United States)

Greenberg, A S; Bailey, J M

2001-08-01

As we learn more about the causes of sexual orientation, the likelihood increases that parents will one day be able to select the orientation of their children. This possibility (at least that of selecting for heterosexuality) has generated a great deal of concern among supporters of homosexual rights, with such selection being widely condemned as harmful and morally repugnant. Notwithstanding this widespread condemnation, and even assuming, as we do, that homosexuality is entirely acceptable morally, allowing parents, by means morally unproblematic in themselves, to select for heterosexuality would be morally acceptable. This is because allowing parents to select their children's sexual orientation would further parent's freedom to raise the sort of children they wish to raise and because selection for heterosexuality may benefit parents and children and is unlikely to cause significant harm.

Relationship of Source Selection Methods to Contract Outcomes: an Analysis of Air Force Source Selection

Science.gov (United States)

2015-12-01

some occasions, performance is terminated early; this can occur due to either mutual agreement or a breach of contract by one of the parties (Garrett...Relationship of Source Selection Methods to Contract Outcomes: an Analysis of Air Force Source Selection December 2015 Capt Jacques Lamoureux, USAF...on the contract management process, with special emphasis on the source selection methods of tradeoff and lowest price technically acceptable (LPTA

K-selection, α-selection, effectiveness, and tolerance in competition ...

Indian Academy of Sciences (India)

selection, effectiveness, and tolerance in ... Evolutionary Biology Laboratory, Evolutionary and Organismal Biology Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, P.O. Box No. 6436, Jakkur, Bangalore 560 064, India; Poornaprajna ...

Sales Tax Compliance and Audit Selection

OpenAIRE

Murray, Matthew N.

1995-01-01

Uses sample selection estimation techniques to identify systematic audit selection rules and determinants of sales tax underreporting. Though based on data from only one state (Tennessee), outcomes are useful in developing and evaluating audit selection results.

Ion-selective electrodes

CERN Document Server

Mikhelson, Konstantin N

2013-01-01

Ion-selective electrodes (ISEs) have a wide range of applications in clinical, environmental, food and pharmaceutical analysis as well as further uses in chemistry and life sciences. Based on his profound experience as a researcher in ISEs and a course instructor, the author summarizes current knowledge for advanced teaching and training purposes with a particular focus on ionophore-based ISEs. Coverage includes the basics of measuring with ISEs, essential membrane potential theory and a comprehensive overview of the various classes of ion-selective electrodes. The principles of constructing I

Selectivity coefficients of ion-selective magnesium electrodes used for simultaneous determination of magnesium and calcium ions.

Science.gov (United States)

Maj-Zurawska, Magdalena; Lewenstam, Andrzej

2011-12-15

Membrane ion-selective magnesium electrodes are commonly used to determine ionized magnesium concentration in blood serum and intracellular fluid by potentiometric clinical analyzers. The selectivity of these electrodes against calcium ion is typically insufficient to avoid calcium interference in blood serum analysis. For this reason the selectivity coefficient for calcium ion has to be studied to make possible any mathematical corrections for calcium ion influence. Existing methods relate to the thermodynamic concept of ISE response which suggest a single constant value of the selectivity coefficient and slope that are stable over the concentration ranges of calcium and magnesium ions in the samples. Unfortunately, this rarely happens, and we rather observe dependences on solution and membrane composition, readout time, matrices (anticoagulant, vial coats) that justify usage of apparent selectivities and slopes. To get the practical insight into the response of magnesium ion-selective electrodes a novel method for estimating the selectivity coefficients and the slope of the electrode characteristics is proposed. This method is an effective starting point for selecting electrodes and designing transient signal software in a potentiometric clinical analyzer. The method allows obtaining the ionized magnesium concentration in blood serum with minimal possible error by addressing the assessed targets, i.e. apparent selectivity and slope. The method is based on computer simulation and on the Nicolsky-Eisenman equation. Usually only a few iterations are needed to obtain stable congruent results. The method presented is particularly useful in conditions where is not possible to obtain calibration curve, which is typical for clinical analyzer where at most three point calibration is performed. Copyright © 2011 Elsevier B.V. All rights reserved.

High Selectivity Oxygen Delignification

Energy Technology Data Exchange (ETDEWEB)

Lucian A. Lucia

2005-11-15

Project Objective: The objectives of this project are as follows: (1) Examine the physical and chemical characteristics of a partner mill pre- and post-oxygen delignified pulp and compare them to lab generated oxygen delignified pulps; (2) Apply the chemical selectivity enhancement system to the partner pre-oxygen delignified pulps under mill conditions (with and without any predetermined amounts of carryover) to determine how efficiently viscosity is preserved, how well selectivity is enhanced, if strength is improved, measure any yield differences and/or bleachability differences; and (3) Initiate a mill scale oxygen delignification run using the selectivity enhancement agent, collect the mill data, analyze it, and propose any future plans for implementation.

Antecedent Selection for Sluicing

DEFF Research Database (Denmark)

Anand, Pranav; Hardt, Daniel

2016-01-01

Sluicing is an elliptical process where the majority of a question can go unpronounced as long as there is a salient antecedent in previous discourse. This paper considers the task of antecedent selection: finding the correct antecedent for a given case of sluicing. We argue that both syntactic...... and discourse relationships are important in antecedent selection, and we construct linguistically sophisticated features that describe the relevant relationships. We also define features that describe the relation of the content of the antecedent and the sluice type. We develop a linear model which achieves...... accuracy of 72.4%, a substantial improvement over a strong manually constructed baseline. Feature analysis confirms that both syntactic and discourse features are important in antecedent selection....

Variable selection in near-infrared spectroscopy: Benchmarking of feature selection methods on biodiesel data

International Nuclear Information System (INIS)

Balabin, Roman M.; Smirnov, Sergey V.

2011-01-01

During the past several years, near-infrared (near-IR/NIR) spectroscopy has increasingly been adopted as an analytical tool in various fields from petroleum to biomedical sectors. The NIR spectrum (above 4000 cm -1 ) of a sample is typically measured by modern instruments at a few hundred of wavelengths. Recently, considerable effort has been directed towards developing procedures to identify variables (wavelengths) that contribute useful information. Variable selection (VS) or feature selection, also called frequency selection or wavelength selection, is a critical step in data analysis for vibrational spectroscopy (infrared, Raman, or NIRS). In this paper, we compare the performance of 16 different feature selection methods for the prediction of properties of biodiesel fuel, including density, viscosity, methanol content, and water concentration. The feature selection algorithms tested include stepwise multiple linear regression (MLR-step), interval partial least squares regression (iPLS), backward iPLS (BiPLS), forward iPLS (FiPLS), moving window partial least squares regression (MWPLS), (modified) changeable size moving window partial least squares (CSMWPLS/MCSMWPLSR), searching combination moving window partial least squares (SCMWPLS), successive projections algorithm (SPA), uninformative variable elimination (UVE, including UVE-SPA), simulated annealing (SA), back-propagation artificial neural networks (BP-ANN), Kohonen artificial neural network (K-ANN), and genetic algorithms (GAs, including GA-iPLS). Two linear techniques for calibration model building, namely multiple linear regression (MLR) and partial least squares regression/projection to latent structures (PLS/PLSR), are used for the evaluation of biofuel properties. A comparison with a non-linear calibration model, artificial neural networks (ANN-MLP), is also provided. Discussion of gasoline, ethanol-gasoline (bioethanol), and diesel fuel data is presented. The results of other spectroscopic

NASA Chandra X-ray Observatory Selected as Editor's Choice in 2000 Discover Magazine Awards for Technological Innovation

Science.gov (United States)

2000-06-01

The Chandra X-ray Observatory, NASA's newest and most powerful X-ray space telescope, has been selected as the winner of the Editor's Choice category of the 2000 Discover Magazine Awards for Technological Innovation. The team of government, industry, university and research institutions that designed, built and deployed Chandra for NASA's Marshall Space Flight Center, Huntsville, Ala, will be formally recognized June 24 at a gala awards celebration at Epcot at the Walt Disney World Resort in Orlando, Fl. Dr. Harvey Tananbaum, director of the Smithsonian Astrophysical Observatory's Chandra X-ray Science Center, Cambridge, Mass., which conducts the Chandra science mission for NASA, will receive the award on behalf of the team. "Chandra has opened a new window for astronomers into the universe of high-energy cosmic events such as pulsars, supernova remnants and black holes," said Tananbaum. "We're now able to create spectacularly detailed images of celestial phenomena whose mere existence we could only hypothesize before." Among Chandra's most significant discoveries to date, he lists the detection of a giant ring around the heart of the Crab Nebula, details of the shock wave created by an exploding star and resolution of the high-energy X-ray "glow" in the universe into millions of specific light sources. "The successful launch, deployment and on-orbit operations of NASA's Chandra X-ray Observatory is a testament to the solid partnership between TRW, NASA and the science community that has been enabling NASA's most important space science missions for the past 40 years," said Timothy W. Hannemann, executive vice president and general manager, TRW Space & Electronics Group. "The extraordinary images that Chandra is delivering daily speaks loudly not only to the quality of the science instruments on board, but also to the engineering talents and dedication to mission success exhibited by every member of NASA's Chandra mission team." Chandra, named in honor of Nobel

Detecting selection needs comparative data

DEFF Research Database (Denmark)

Nielsen, Rasmus; Hubisz, Melissa J.

2005-01-01

Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al. 1 describe a new method for detecting positive selection based on a single nucleotide sequence. We show here...... that this method is particularly sensitive to assumptions regarding the underlying mutational processes and does not provide a reliable way to identify positive selection....

Finding Direction in the Search for Selection.

Science.gov (United States)

Thiltgen, Grant; Dos Reis, Mario; Goldstein, Richard A

2017-01-01

Tests for positive selection have mostly been developed to look for diversifying selection where change away from the current amino acid is often favorable. However, in many cases we are interested in directional selection where there is a shift toward specific amino acids, resulting in increased fitness in the species. Recently, a few methods have been developed to detect and characterize directional selection on a molecular level. Using the results of evolutionary simulations as well as HIV drug resistance data as models of directional selection, we compare two such methods with each other, as well as against a standard method for detecting diversifying selection. We find that the method to detect diversifying selection also detects directional selection under certain conditions. One method developed for detecting directional selection is powerful and accurate for a wide range of conditions, while the other can generate an excessive number of false positives.

Non-additive Effects in Genomic Selection

Directory of Open Access Journals (Sweden)

Luis Varona

2018-03-01

Full Text Available In the last decade, genomic selection has become a standard in the genetic evaluation of livestock populations. However, most procedures for the implementation of genomic selection only consider the additive effects associated with SNP (Single Nucleotide Polymorphism markers used to calculate the prediction of the breeding values of candidates for selection. Nevertheless, the availability of estimates of non-additive effects is of interest because: (i they contribute to an increase in the accuracy of the prediction of breeding values and the genetic response; (ii they allow the definition of mate allocation procedures between candidates for selection; and (iii they can be used to enhance non-additive genetic variation through the definition of appropriate crossbreeding or purebred breeding schemes. This study presents a review of methods for the incorporation of non-additive genetic effects into genomic selection procedures and their potential applications in the prediction of future performance, mate allocation, crossbreeding, and purebred selection. The work concludes with a brief outline of some ideas for future lines of that may help the standard inclusion of non-additive effects in genomic selection.

Directed evolution: selecting today's biocatalysts : selecting today's biocatalysts

NARCIS (Netherlands)

Otten, Linda; Quax, Wim

2005-01-01

Directed evolution has become a full-grown tool in molecular biology nowadays. The methods that are involved in creating a mutant library are extensive and can be divided into several categories according to their basic ideas. Furthermore, both screening and selection can be used to target the

Selection - factors and influences on training

International Nuclear Information System (INIS)

Bruno, R.J.; Mascitti, A.P.

1987-01-01

Personnel performance is certainly the goal of training programs and the impact of personnel performance on plant performance indicators is well known. This presentation discusses the selection of personnel prior to training and emphasizes the need for selection criteria to include aptitude intelligence, mechanical ability, work ethic, and emotional stability. Selected data is presented from Point Beach that support a rigorous selection and screening program to ensure training successfully prepared these personnel for job assignments

Nuclear site selection studies

International Nuclear Information System (INIS)

Gharib, A.; Zohoorian Izadpanah, A.A.; Iranmanesh, H.

2000-01-01

It is of special importance, especially from the nuclear safety viewpoint, to select suitable sites for different nuclear structures with the considered future activities. Site selection sometimes involves high costs not necessarily for merely selecting of site but for some preliminary measures to be taken so as the site may have the necessary characteristics. The more suitable the natural characteristics of the site for the considered project, the more successful and efficient the project, the lower the project costs and the longer the project operation period. If so, the project will cause the growth of public culture and sustainable socioeconomic development. This paper is the result of the conclusion of numerous massive reports of this activity in the preliminary phase based on theories, practices and the related safety principles on this ground as well as the application of data and information of the past and a glance to the future. The conception of need for a site for medium structures and nuclear research projects and how to perform this process are presented step by step here with a scientific approach to its selection during the investigations. In this study, it is practically described how the site is selected, by determining and defining the characteristics of research and nuclear projects with medium structures and also its fitting to the optimum site. The discovered sites typically involve the best advantages in technical and economic aspects and no particular contrast with the concerned structures

Recruitment and selection of employees

OpenAIRE

Čermochová, Barbora

2017-01-01

The Bachelor's thesis focuses on the process of recruitment and selection of employees. The thesis is divided into theoretical and practical part. The theoretical part includes concepts that are important for understanding of issues of the process of recruitment and selection of employees. The practical part is divided into three chapters. The first chapter briefly describes the company xxx. Next two chapters deal with the process of recruitment and selection of employees in the company. The ...

Selective solvent extraction of oils

Energy Technology Data Exchange (ETDEWEB)

1938-04-09

In the selective solvent extraction of naphthenic base oils, the solvent used consists of the extract obtained by treating a paraffinic base oil with a selective solvent. The extract, or partially spent solvent is less selective than the solvent itself. Selective solvents specified for the extraction of the paraffinic base oil are phenol, sulphur dioxide, cresylic acid, nitrobenzene, B:B/sup 1/-dichlorethyl ether, furfural, nitroaniline and benzaldehyde. Oils treated are Coastal lubricating oils, or naphthenic oils from the cracking, or destructive hydrogenation of coal, tar, lignite, peat, shale, bitumen, or petroleum. The extraction may be effected by a batch or counter-current method, and in the presence of (1) liquefied propane, or butane, or naphtha, or (2) agents which modify the solvent power such as, water, ammonia, acetonitrile, glycerine, glycol, caustic soda or potash. Treatment (2) may form a post-treatment effected on the extract phase. In counter-current treatment in a tower some pure selective solvent may be introduced near the raffinate outlet to wash out any extract therefrom.

Supplier selection using different metric functions

Directory of Open Access Journals (Sweden)

Omosigho S.E.

2015-01-01

Full Text Available Supplier selection is an important component of supply chain management in today’s global competitive environment. Hence, the evaluation and selection of suppliers have received considerable attention in the literature. Many attributes of suppliers, other than cost, are considered in the evaluation and selection process. Therefore, the process of evaluation and selection of suppliers is a multi-criteria decision making process. The methodology adopted to solve the supplier selection problem is intuitionistic fuzzy TOPSIS (Technique for Order Preference by Similarity to the Ideal Solution. Generally, TOPSIS is based on the concept of minimum distance from the positive ideal solution and maximum distance from the negative ideal solution. We examine the deficiencies of using only one metric function in TOPSIS and propose the use of spherical metric function in addition to the commonly used metric functions. For empirical supplier selection problems, more than one metric function should be used.

Hard and Soft Selection Revisited: How Evolution by Natural Selection Works in the Real World.

Science.gov (United States)

Reznick, David

2016-01-01

The modern synthesis of evolutionary biology unified Darwin's natural selection with Mendelian genetics, but at the same time it created the dilemma of genetic load. Lewontin and Hubby's (1966) and Harris's (1966) characterization of genetic variation in natural populations increased the apparent burden of this load. Neutrality or near neutrality of genetic variation was one mechanism proposed for the revealed excessive genetic variation. Bruce Wallace coined the term "soft selection" to describe an alternative way for natural selection to operate that was consistent with observed variation. He envisioned nature as presenting ecological vacancies that could be filled by diverse genotypes. Survival and successful reproduction was a combined function of population density, genotype, and genotype frequencies, rather than a fixed value of the relative fitness of each genotype. My goal in this review is to explore the importance of soft selection in the real world. My motive and that of my colleagues as described here is not to explain what maintains genetic variation in natural populations, but rather to understand the factors that shape how organisms adapt to natural environments. We characterize how feedbacks between ecology and evolution shape both evolution and ecology. These feedbacks are mediated by density- and frequency-dependent selection, the mechanisms that underlie soft selection. Here, I report on our progress in characterizing these types of selection with a combination of a consideration of the published literature and the results from my collaborators' and my research on natural populations of guppies. © The American Genetic Association. 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

INDUSTRIAL BOILER RETROFIT FOR NOX CONTROL: COMBINED SELECTIVE NONCATALYTIC REDUCTION AND SELECTIVE CATALYTIC REDUCTION

Science.gov (United States)

The paper describes retrofitting and testing a 590 kW (2 MBtu/hr), oil-fired, three-pass, fire-tube package boiler with a combined selective noncatalytic reduction (SNCR) and selective catalytic reduction (SCR) system. The system demonstrated 85% nitrogen oxides (NOx) reduction w...

Ion-selective electrodes

Energy Technology Data Exchange (ETDEWEB)

Mikhelson, Konstantin N. [St. Petersburg State Univ. (Russian Federation). Ion-Selective Electrode Laboratory

2013-06-01

Ion-selective electrodes (ISEs) have a wide range of applications in clinical, environmental, food and pharmaceutical analysis as well as further uses in chemistry and life sciences. Based on his profound experience as a researcher in ISEs and a course instructor, the author summarizes current knowledge for advanced teaching and training purposes with a particular focus on ionophore-based ISEs. Coverage includes the basics of measuring with ISEs, essential membrane potential theory and a comprehensive overview of the various classes of ion-selective electrodes. The principles of constructing ISEs are outlined, and the transfer of methods into routine analysis is considered.

Selective gossip

NARCIS (Netherlands)

Üstebay, D.; Castro, R.M.; Rabbat, M.

2009-01-01

Motivated by applications in compression and distributed transform coding, we propose a new gossip algorithm called Selective Gossip to efficiently compute sparse approximations of network data. We consider running parallel gossip algorithms on the elements of a vector of transform coefficients.

Social selection is a powerful explanation for prosociality.

Science.gov (United States)

Nesse, Randolph M

2016-01-01

Cultural group selection helps explain human cooperation, but social selection offers a complementary, more powerful explanation. Just as sexual selection shapes extreme traits that increase matings, social selection shapes extreme traits that make individuals preferred social partners. Self-interested partner choices create strong and possibly runaway selection for prosocial traits, without requiring group selection, kin selection, or reciprocity.

A selective review of selective attention research from the past century.

Science.gov (United States)

Driver, J

2001-02-01

Research on attention is concerned with selective processing of incoming sensory information. To some extent, our awareness of the world depends on what we choose to attend, not merely on the stimulation entering our senses. British psychologists have made substantial contributions to this topic in the past century. Celebrated examples include Donald Broadbent's filter theory of attention, which set the agenda for most subsequent work; and Anne Treisman's revisions of this account, and her later feature-integration theory. More recent contributions include Alan Allport's prescient emphasis on the relevance of neuroscience data, and John Duncan's integration of such data with psychological theory. An idiosyncratic but roughly chronological review of developments is presented, some practical and clinical implications are briefly sketched, and future directions suggested. One of the biggest changes in the field has been the increasing interplay between psychology and neuroscience, which promises much for the future. A related change has been the realization that selection attention is best thought of as a broad topic, encompassing a range of selective issues, rather than as a single explanatory process.

Fuzzy target selection using RFM variables

NARCIS (Netherlands)

Kaymak, U.

2001-01-01

An important data mining problem from the world of direct marketing is target selection. The main task in target selection is the determination of potential customers for a product from a client database. Target selection algorithms identify the profiles of customer groups for a particular product,

5 CFR 720.206 - Selection guidelines.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Selection guidelines. 720.206 Section 720... guidelines. This subpart sets forth requirements for a recruitment program, not a selection program... procedures and criteria must be consistent with the Uniform Guidelines on Employee Selection Procedures (43...

Selection decisions among reindeer herders in Finland

Directory of Open Access Journals (Sweden)

Kirsi Muuttoranta

2011-04-01

Full Text Available Selection of breeding animals is a tool to improve the revenues in animal production. Information about selection practices and criteria are essential in assessing the possibilities for systematic selection schemes. Attitudes of reindeer herders towards use of selection in improving production were investigated by means of interviews. We interviewed the managers of reindeer herding cooperatives concerning their selection decisions. Fortyfive out of 56 managers answered to the semi-structured questionnaire. Among herding operations, selection of breeding animals was regarded by managers as critical for calf’s autumn weight and survival. The main selection criteria were calf’s health, vigour, body size and muscularity, dam or dam line, and maternal care. Hair quality and hair length were important as well, while such often quoted traits as antler characteristics, e.g. early shedding of antler velvet and thick antler bases, were unimportant. The results show that reindeer herders i acknowledge the importance and effects of selective breeding, and ii have empirical knowledge to list the most important selection criteria.

Familial versus mass selection in small populations

Directory of Open Access Journals (Sweden)

Couvet Denis

2003-07-01

Full Text Available Abstract We used diffusion approximations and a Markov-chain approach to investigate the consequences of familial selection on the viability of small populations both in the short and in the long term. The outcome of familial selection was compared to the case of a random mating population under mass selection. In small populations, the higher effective size, associated with familial selection, resulted in higher fitness for slightly deleterious and/or highly recessive alleles. Conversely, because familial selection leads to a lower rate of directional selection, a lower fitness was observed for more detrimental genes that are not highly recessive, and with high population sizes. However, in the long term, genetic load was almost identical for both mass and familial selection for populations of up to 200 individuals. In terms of mean time to extinction, familial selection did not have any negative effect at least for small populations (N ≤ 50. Overall, familial selection could be proposed for use in management programs of small populations since it increases genetic variability and short-term viability without impairing the overall persistence times.

Managing the Public Sector Research and Development Portfolio Selection Process: A Case Study of Quantitative Selection and Optimization

Science.gov (United States)

2016-09-01

PUBLIC SECTOR RESEARCH & DEVELOPMENT PORTFOLIO SELECTION PROCESS: A CASE STUDY OF QUANTITATIVE SELECTION AND OPTIMIZATION by Jason A. Schwartz...PUBLIC SECTOR RESEARCH & DEVELOPMENT PORTFOLIO SELECTION PROCESS: A CASE STUDY OF QUANTITATIVE SELECTION AND OPTIMIZATION 5. FUNDING NUMBERS 6...describing how public sector organizations can implement a research and development (R&D) portfolio optimization strategy to maximize the cost

Intervention with the Selectively Mute Child.

Science.gov (United States)

Porjes, Michelle D.

1992-01-01

Defines selective mutism as describing children who actively choose to speak to few people in selected environments, noting it is most commonly used to describe nonverbal behavior in school setting. Reviews literature from psychoanalytic and learning theory approaches. Presents intervention strategies used with two selectively mute first graders.…

Pedagogical basement of sport selection.

Directory of Open Access Journals (Sweden)

Abdullaev A.K.

2011-08-01

Full Text Available We consider the problem of relevance, goals, objectives psychological selection of sports heroes. The analysis of the literature reveals the stages of the selection of fighters, revealed three interdependent parts of the selection of athletes as part of the wrestling coach. Established that the content and focus of initial training for wrestling must meet age, stage of training, the level of preparedness practitioners. So it is proved that the intellectual sphere of athletes is mediocre and the average level of development.

Measurement invariance versus selection invariance: Is fair selection possible?

NARCIS (Netherlands)

Borsboom, D.; Romeijn, J.W.; Wicherts, J.M.

2008-01-01

This article shows that measurement invariance (defined in terms of an invariant measurement model in different groups) is generally inconsistent with selection invariance (defined in terms of equal sensitivity and specificity across groups). In particular, when a unidimensional measurement

Measurement invariance versus selection invariance : Is fair selection possible?

NARCIS (Netherlands)

Borsboom, Denny; Romeijn, Jan-Willem; Wicherts, Jelte M.

This article shows that measurement invariance (defined in terms of an invariant measurement model in different groups) is generally inconsistent with selection invariance (defined in terms of equal sensitivity and specificity across groups). In particular, when a unidimensional measurement

Genomic selection improves response to selection in resilience by exploiting genotype by environment interactions

Directory of Open Access Journals (Sweden)

Han Mulder

2016-10-01

Full Text Available Genotype by environment interactions (GxE are very common in livestock and hamper genetic improvement. On the other hand, GxE is a source of genetic variation: genetic variation in response to environment, e.g. environmental perturbations such as heat stress or disease. In livestock breeding, there is tendency to ignore GxE because of increased complexity of models for genetic evaluations and lack of accuracy in extreme environments. GxE, however, creates opportunities to increase resilience of animals towards environmental perturbations. The main aim of the paper is to investigate to which extent GxE can be exploited with traditional and genomic selection methods. Furthermore, we investigated the benefit of reaction norm models compared to conventional methods ignoring GxE. The questions were addressed with selection index theory. GxE was modelled according to a linear reaction norm model in which the environmental gradient is the contemporary group mean. Economic values were based on linear and non-linear profit equations.Accuracies of environment-specific (GEBV were highest in intermediate environments and lowest in extreme environments. Reaction norm models had higher accuracies of (GEBV in extreme environments than conventional models ignoring GxE. Genomic selection always resulted in higher response to selection in all environments than sib or progeny testing schemes. The increase in response was with genomic selection between 9% and 140% compared to sib testing and between 11% and 114% compared to progeny testing when the reference population consisted of 1 million animals across all environments. When the aim was to decrease environmental sensitivity, the response in slope of the reaction norm model with genomic selection was between 1.09 and 319 times larger than with sib or progeny testing and in the right direction in contrast to sib and progeny testing that still increased environmental sensitivity. This shows that genomic selection

Location selection in the visual domain

NARCIS (Netherlands)

van der Lubbe, Robert Henricus Johannes; Woestenburg, Jaap C.

2000-01-01

According to A.H.C. Van der Heijden (1992), attentional selection of visual stimuli can be considered as location selection. Depending on the type of task, location selection can be considered to be automatic )e.g., in case of abrupt onsets), directly controlled (e.g., in case of symbolic precues),

Response to family selection and genetic parameters in Japanese quail selected for four week breast weight

DEFF Research Database (Denmark)

Khaldari, Majid; Yeganeh, Hassan Mehrabani; Pakdel, Abbas

2011-01-01

An experiment was conducted to investigate the effect of short-term selection for 4 week breast weight (4wk BRW), and to estimate genetic parameters of body weight, and carcass traits. A selection (S) line and control (C) line was randomly selected from a base population. Data were collected over...... was 0.35±0.06. There were a significant difference for BW, and carcass weights but not for carcass percent components between lines (Pcarcass and leg weights were 0.46, 0.41 and 0.47, and 13.2, 16.2, 4.4 %, respectively....... The genetic correlations of BRW with BW, carcass, leg, and back weights were 0.85, 0.88 and 0.72, respectively. Selection for 4 wk BRW improved feed conversion ratio (FCR) about 0.19 units over the selection period. Inbreeding caused an insignificant decline of the mean of some traits. Results from...

A Selection Method for COTS Systems

DEFF Research Database (Denmark)

Hedman, Jonas

new skills and methods supporting the process of evaluating and selecting information systems. This paper presents a method for selecting COTS systems. The method includes the following phases: problem framing, requirements and appraisal, and selection of systems. The idea and distinguishing feature...... behind the method is that improved understanding of organizational' ends' or goals should govern the selection of a COTS system. This can also be expressed as a match or fit between ‘ends' (e.g. improved organizational effectiveness) and ‘means' (e.g. implementing COTS systems). This way of approaching...

Signatures of positive selection: from selective sweeps at individual loci to subtle allele frequency changes in polygenic adaptation.

Science.gov (United States)

Stephan, Wolfgang

2016-01-01

In the past 15 years, numerous methods have been developed to detect selective sweeps underlying adaptations. These methods are based on relatively simple population genetic models, including one or two loci at which positive directional selection occurs, and one or two marker loci at which the impact of selection on linked neutral variation is quantified. Information about the phenotype under selection is not included in these models (except for fitness). In contrast, in the quantitative genetic models of adaptation, selection acts on one or more phenotypic traits, such that a genotype-phenotype map is required to bridge the gap to population genetics theory. Here I describe the range of population genetic models from selective sweeps in a panmictic population of constant size to evolutionary traffic when simultaneous sweeps at multiple loci interfere, and I also consider the case of polygenic selection characterized by subtle allele frequency shifts at many loci. Furthermore, I present an overview of the statistical tests that have been proposed based on these population genetics models to detect evidence for positive selection in the genome. © 2015 John Wiley & Sons Ltd.

Opportunistic Relay Selection With Limited Feedback

KAUST Repository

Eltayeb, Mohammed E.

2015-08-01

Relay selection is a simple technique that achieves spatial diversity in cooperative relay networks. Generally, relay selection algorithms require channel state information (CSI) feedback from all cooperating relays to make a selection decision. This requirement poses two important challenges, which are often neglected in the literature. Firstly, the fed back channel information is usually corrupted by additive noise. Secondly, CSI feedback generates a great deal of feedback overhead (air-time) that could result in significant performance hits. In this paper, we propose a compressive sensing (CS) based relay selection algorithm that reduces the feedback overhead of relay networks under the assumption of noisy feedback channels. The proposed algorithm exploits CS to first obtain the identity of a set of relays with favorable channel conditions. Following that, the CSI of the identified relays is estimated using least squares estimation without any additional feedback. Both single and multiple relay selection cases are considered. After deriving closed-form expressions for the asymptotic end-to-end SNR at the destination and the feedback load for different relaying protocols, we show that CS-based selection drastically reduces the feedback load and achieves a rate close to that obtained by selection algorithms with dedicated error-free feedback. © 1972-2012 IEEE.

Selecting practice management information systems.

Science.gov (United States)

Worley, R; Ciotti, V

1997-01-01

Despite enormous advances in information systems, the process by which most medical practices select them has remained virtually unchanged for decades: the request for proposal (RFP). Unfortunately, vendors have learned ways to minimize the value of RFP checklists to where purchasers now learn little about the system functionality. The authors describe a selection methodology that replaces the RFP with scored demos, reviews of vendor user manuals and mathematically structured reference checking. In a recent selection process at a major medical center, these techniques yielded greater user buy-in and favorable contract terms as well.

Molecular Signatures of Natural Selection

DEFF Research Database (Denmark)

Nielsen, Rasmus

2005-01-01

provide important functional information. This review provides a nonmathematical description of the issues involved in detecting selection from DNA sequences and SNP data and is intended for readers who are not familiar with population genetic theory. Particular attention is placed on issues relating......There is an increasing interest in detecting genes, or genomic regions, that have been targeted by natural selection. The interest stems from a basic desire to learn more about evolutionary processes in humans and other organisms, and from the realization that inferences regarding selection may...

[Silvicultural treatments and their selection effects].

Science.gov (United States)

Vincent, G

1973-01-01

Selection can be defined in terms of its observable consequences as the non random differential reproduction of genotypes (Lerner 1958). In the forest stands we are selecting during the improvements-fellings and reproduction treatments the individuals surpassing in growth or in production of first-class timber. However the silvicultural treatments taken in forest stands guarantee a permanent increase of forest production only in such cases, if they have been taken with respect to the principles of directional (dynamic) selection. These principles require that the trees determined for further growing and for forest regeneration are selected by their hereditary properties, i.e. by their genotypes.For making this selection feasible, our study deals with the genetic parameters and gives some examples of the application of the response, the selection differential, the heritability in the narrow and in the broad sense, as well as of the genetic and genotypic gain. On the strength of this parameter we have the possibility to estimate the economic success of several silvicultural treatments in forest stands.The mentioned examples demonstrate that the selection measures of a higher intensity will be manifested in a higher selection differential, in a higher genetic and genotypic gain and that the mentioned measures show more distinct effects in the variable populations - in natural forest - than in the population characteristic by a smaller variability, e.g. in many uniform artificially established stands.The examples of influences of different selection on the genotypes composition of population prove that genetics instructs us to differentiate the different genotypes of the same species and gives us at the same time a new criterions for evaluating selectional treatments. These criterions from economic point of view is necessary to consider in silviculture as advantageous even for the reason that we can judge from these criterions the genetical composition of forest stands

Procreative altruism: beyond individualism in reproductive selection.

Science.gov (United States)

Douglas, Thomas; Devolder, Katrien

2013-08-01

Existing debate on procreative selection focuses on the well-being of the future child. However, selection decisions can also have significant effects on the well-being of others. Moreover, these effects may run in opposing directions; some traits conducive to the well-being of the selected child may be harmful to others, whereas other traits that limit the child's well-being may preserve or increase that of others. Prominent selection principles defended to date instruct parents to select a child, of the possible children they could have, likely to have a good (or nonbad) life, but they do not instruct parents to independently take the well-being of others into account. We refer to these principles as individualistic selection principles. We propose a new selection principle-Procreative Altruism-according to which parents have significant moral reason to select a child whose existence can be expected to contribute more to (or detract less from) the well-being of others than any alternative child they could have. We present the case for adopting Procreative Altruism alongside any of the major individualistic selection principles proposed to date and defend this two-principle model against a range of objections.

Estimating uncertainty in multivariate responses to selection.

Science.gov (United States)

Stinchcombe, John R; Simonsen, Anna K; Blows, Mark W

2014-04-01

Predicting the responses to natural selection is one of the key goals of evolutionary biology. Two of the challenges in fulfilling this goal have been the realization that many estimates of natural selection might be highly biased by environmentally induced covariances between traits and fitness, and that many estimated responses to selection do not incorporate or report uncertainty in the estimates. Here we describe the application of a framework that blends the merits of the Robertson-Price Identity approach and the multivariate breeder's equation to address these challenges. The approach allows genetic covariance matrices, selection differentials, selection gradients, and responses to selection to be estimated without environmentally induced bias, direct and indirect selection and responses to selection to be distinguished, and if implemented in a Bayesian-MCMC framework, statistically robust estimates of uncertainty on all of these parameters to be made. We illustrate our approach with a worked example of previously published data. More generally, we suggest that applying both the Robertson-Price Identity and the multivariate breeder's equation will facilitate hypothesis testing about natural selection, genetic constraints, and evolutionary responses. © 2013 The Author(s). Evolution © 2013 The Society for the Study of Evolution.

Partner selection and Hollywood Films

DEFF Research Database (Denmark)

Grodal, Torben Kragh; Kramer, Mette

2012-01-01

Based on cognitive, neurological and evolutionary based film theory the article describes the representation of partner selection in Hollywood films. It analyses paradigm scenarios of partner selection and love, It further describes some of those mechanisms that regulate the relation between...

5 CFR 330.1105 - Selection.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Selection. 330.1105 Section 330.1105 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RECRUITMENT, SELECTION, AND PLACEMENT (GENERAL) Federal Employment Priority Consideration Program for Displaced Employees of the...

Selective androgen receptor modulators: in pursuit of tissue-selective androgens.

Science.gov (United States)

Omwancha, Josephat; Brown, Terry R

2006-10-01

The androgen receptor mediates the androgenic and anabolic activity of the endogenous steroids testosterone and 5alpha-dihydrotestosterone. Current knowledge of the androgen receptor protein structure, and the molecular mechanisms surrounding the binding properties and activities of agonists and antagonists has led to the design and development of novel nonsteroidal ligands with selected tissue-specific androgen receptor agonist and antagonist activities. The activity of these compounds, termed selective androgen receptor modulators (SARMs), is directed toward the maintenance or enhancement of anabolic effects on bone and muscle with minimal androgenic effects on prostate growth. SARMs are of potential therapeutic value in the treatment of male hypogonadism, osteoporosis, frailty and muscle wasting, burn injury and would healing, anemia, mood and depression, benign prostatic hyperplasia and prostate cancer.

MIS-based sensors with hydrogen selectivity

Energy Technology Data Exchange (ETDEWEB)

Li,; Dongmei, [Boulder, CO; Medlin, J William [Boulder, CO; McDaniel, Anthony H [Livermore, CA; Bastasz, Robert J [Livermore, CA

2008-03-11

The invention provides hydrogen selective metal-insulator-semiconductor sensors which include a layer of hydrogen selective material. The hydrogen selective material can be polyimide layer having a thickness between 200 and 800 nm. Suitable polyimide materials include reaction products of benzophenone tetracarboxylic dianhydride 4,4-oxydianiline m-phenylene diamine and other structurally similar materials.

How does male–male competition generate negative frequency-dependent selection and disruptive selection during speciation?

Science.gov (United States)

Border, Shana E

2018-01-01

Abstract Natural selection has been shown to drive population differentiation and speciation. The role of sexual selection in this process is controversial; however, most of the work has centered on mate choice while the role of male–male competition in speciation is relatively understudied. Here, we outline how male–male competition can be a source of diversifying selection on male competitive phenotypes, and how this can contribute to the evolution of reproductive isolation. We highlight how negative frequency-dependent selection (advantage of rare phenotype arising from stronger male–male competition between similar male phenotypes compared with dissimilar male phenotypes) and disruptive selection (advantage of extreme phenotypes) drives the evolution of diversity in competitive traits such as weapon size, nuptial coloration, or aggressiveness. We underscore that male–male competition interacts with other life-history functions and that variable male competitive phenotypes may represent alternative adaptive options. In addition to competition for mates, aggressive interference competition for ecological resources can exert selection on competitor signals. We call for a better integration of male–male competition with ecological interference competition since both can influence the process of speciation via comparable but distinct mechanisms. Altogether, we present a more comprehensive framework for studying the role of male–male competition in speciation, and emphasize the need for better integration of insights gained from other fields studying the evolutionary, behavioral, and physiological consequences of agonistic interactions. PMID:29492042

Selecting Soldiers and Civilians into the U.S. Army Officer Candidate School : Developing Empirical Selection Composites

Science.gov (United States)

2014-07-01

ultimately led to the development of the Officer Selection Battery ( OSB ),4 which was administered to incoming OCS candidates in 1975. The Army...officially authorized the use of the OSB for selecting OCS candidates in 1979, where it remained for a number of years. However, no other selection tool...replaced the OSB for screening OCS candidates after it was dropped from use. The current eligibility requirements for both in-service and

Genomic Selection Using Extreme Phenotypes and Pre-Selection of SNPs in Large Yellow Croaker (Larimichthys crocea).

Science.gov (United States)

Dong, Linsong; Xiao, Shijun; Chen, Junwei; Wan, Liang; Wang, Zhiyong

2016-10-01

Genomic selection (GS) is an effective method to improve predictive accuracies of genetic values. However, high cost in genotyping will limit the application of this technology in some species. Therefore, it is necessary to find some methods to reduce the genotyping costs in genomic selection. Large yellow croaker is one of the most commercially important marine fish species in southeast China and Eastern Asia. In this study, genotyping-by-sequencing was used to construct the libraries for the NGS sequencing and find 29,748 SNPs in the genome. Two traits, eviscerated weight (EW) and the ratio between eviscerated weight and whole body weight (REW), were chosen to study. Two strategies to reduce the costs were proposed as follows: selecting extreme phenotypes (EP) for genotyping in reference population or pre-selecting SNPs to construct low-density marker panels in candidates. Three methods of pre-selection of SNPs, i.e., pre-selecting SNPs by absolute effects (SE), by single marker analysis (SMA), and by fixed intervals of sequence number (EL), were studied. The results showed that using EP was a feasible method to save the genotyping costs in reference population. Heritability did not seem to have obvious influences on the predictive abilities estimated by EP. Using SMA was the most feasible method to save the genotyping costs in candidates. In addition, the combination of EP and SMA in genomic selection also showed good results, especially for trait of REW. We also described how to apply the new methods in genomic selection and compared the genotyping costs before and after using the new methods. Our study may not only offer a reference for aquatic genomic breeding but also offer a reference for genomic prediction in other species including livestock and plants, etc.

Timothy grass pollen extract-induced gene expression and signalling pathways in airway epithelial cells

NARCIS (Netherlands)

Röschmann, K. I. L.; Luiten, S.; Jonker, M. J.; Breit, T. M.; Fokkens, W. J.; Petersen, A.; van Drunen, C. M.

2011-01-01

Grass pollen allergy is one of the most common allergies worldwide and airborne allergens are the major cause of allergic rhinitis. Airway epithelial cells (AECs) are the first to encounter and respond to aeroallergens and are therefore interesting targets for the development of new therapeutics.

Timothy grass pollen extract-induced gene expression and signalling pathways in airway epithelial cells

NARCIS (Netherlands)

Röschmann, K.I.L.; Luiten, S.; Jonker, M.J.; Breit, T.M.; Fokkens, W.J.; Petersen, A.; van Drunen, C.M.

2011-01-01

Background: Grass pollen allergy is one of the most common allergies worldwide and airborne allergens are the major cause of allergic rhinitis. Airway epithelial cells (AECs) are the first to encounter and respond to aeroallergens and are therefore interesting targets for the development of new

Natural selection promotes antigenic evolvability

NARCIS (Netherlands)

Graves, C.J.; Ros, V.I.D.; Stevenson, B.; Sniegowski, P.D.; Brisson, D.

2013-01-01

The hypothesis that evolvability - the capacity to evolve by natural selection - is itself the object of natural selection is highly intriguing but remains controversial due in large part to a paucity of direct experimental evidence. The antigenic variation mechanisms of microbial pathogens provide

32 CFR 1624.3 - Age selection groups.

Science.gov (United States)

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Age selection groups. 1624.3 Section 1624.3....3 Age selection groups. Age selection groups are established as follows: (a) The age 20 selection group for each calendar year consists of registrants who have attained or will attain the age of 20 in...

Recruiter Selection Model

National Research Council Canada - National Science Library

Halstead, John B

2006-01-01

.... The research uses a combination of statistical learning, feature selection methods, and multivariate statistics to determine the better prediction function approximation with features obtained...

Context-Aware HCI Service Selection

Directory of Open Access Journals (Sweden)

Yao Shen

2012-01-01

Full Text Available Context-awareness has become a key issue in Human-Computer Interaction(HCI to provide better user experience under multi-device and multi-modal environment. With this intuition, we have proposed a web service based framework, which associates interactions with services, and provided service selection mechanism using context knowledge to achieve smart interaction migration [1]. A fundamental problem of such a service-oriented framework for interaction migration is to design an effective while scalable algorithm for service selection. In this paper, we propose a service selection algorithm considering not only context information and user preferences but also inter-service relations such as relative location. Our algorithm detects interaction hot spots within user active scope and presents the best service combination based on evaluation of interaction effectiveness. We also conduct simulation and the results illustrate that our algorithm is effective and scalable for interaction service selection.

Differences in exam performance between pupils attending selective and non-selective schools mirror the genetic differences between them

Science.gov (United States)

Smith-Woolley, Emily; Pingault, Jean-Baptiste; Selzam, Saskia; Rimfeld, Kaili; Krapohl, Eva; von Stumm, Sophie; Asbury, Kathryn; Dale, Philip S.; Young, Toby; Allen, Rebecca; Kovas, Yulia; Plomin, Robert

2018-03-01

On average, students attending selective schools outperform their non-selective counterparts in national exams. These differences are often attributed to value added by the school, as well as factors schools use to select pupils, including ability, achievement and, in cases where schools charge tuition fees or are located in affluent areas, socioeconomic status. However, the possible role of DNA differences between students of different schools types has not yet been considered. We used a UK-representative sample of 4814 genotyped students to investigate exam performance at age 16 and genetic differences between students in three school types: state-funded, non-selective schools (`non-selective'), state-funded, selective schools (`grammar') and private schools, which are selective (`private'). We created a genome-wide polygenic score (GPS) derived from a genome-wide association study of years of education (EduYears). We found substantial mean genetic differences between students of different school types: students in non-selective schools had lower EduYears GPS compared to those in grammar (d = 0.41) and private schools (d = 0.37). Three times as many students in the top EduYears GPS decile went to a selective school compared to the bottom decile. These results were mirrored in the exam differences between school types. However, once we controlled for factors involved in pupil selection, there were no significant genetic differences between school types, and the variance in exam scores at age 16 explained by school type dropped from 7% to <1%. These results show that genetic and exam differences between school types are primarily due to the heritable characteristics involved in pupil admission.

Reserve selection with land market feedbacks.

Science.gov (United States)

Butsic, Van; Lewis, David J; Radeloff, Volker C

2013-01-15

How to best site reserves is a leading question for conservation biologists. Recently, reserve selection has emphasized efficient conservation: maximizing conservation goals given the reality of limited conservation budgets, and this work indicates that land market can potentially undermine the conservation benefits of reserves by increasing property values and development probabilities near reserves. Here we propose a reserve selection methodology which optimizes conservation given both a budget constraint and land market feedbacks by using a combination of econometric models along with stochastic dynamic programming. We show that amenity based feedbacks can be accounted for in optimal reserve selection by choosing property price and land development models which exogenously estimate the effects of reserve establishment. In our empirical example, we use previously estimated models of land development and property prices to select parcels to maximize coarse woody debris along 16 lakes in Vilas County, WI, USA. Using each lake as an independent experiment, we find that including land market feedbacks in the reserve selection algorithm has only small effects on conservation efficacy. Likewise, we find that in our setting heuristic (minloss and maxgain) algorithms perform nearly as well as the optimal selection strategy. We emphasize that land market feedbacks can be included in optimal reserve selection; the extent to which this improves reserve placement will likely vary across landscapes. Copyright © 2012 Elsevier Ltd. All rights reserved.

Advertising media selection and planning

NARCIS (Netherlands)

Moorman, M.; Neijens, P.C.; Smit, E.G.; Belch, M.A.; Belch, G.E.

2010-01-01

Reach, frequency, and timing are key concepts in selecting TV, radio, newspapers, magazines, out-of-home, direct mail, Internet, and other media for advertising campaigns. We discuss these concepts and their role in media selection and media planning processes. We also describe media and audience

Materials Selection for Aerospace Systems

Science.gov (United States)

Arnold, Steven M.; Cebon, David; Ashby, Mike

2012-01-01

A systematic design-oriented, five-step approach to material selection is described: 1) establishing design requirements, 2) material screening, 3) ranking, 4) researching specific candidates and 5) applying specific cultural constraints to the selection process. At the core of this approach is the definition performance indices (i.e., particular combinations of material properties that embody the performance of a given component) in conjunction with material property charts. These material selection charts, which plot one property against another, are introduced and shown to provide a powerful graphical environment wherein one can apply and analyze quantitative selection criteria, such as those captured in performance indices, and make trade-offs between conflicting objectives. Finding a material with a high value of these indices maximizes the performance of the component. Two specific examples pertaining to aerospace (engine blades and pressure vessels) are examined, both at room temperature and elevated temperature (where time-dependent effects are important) to demonstrate the methodology. The discussion then turns to engineered/hybrid materials and how these can be effectively tailored to fill in holes in the material property space, so as to enable innovation and increases in performance as compared to monolithic materials. Finally, a brief discussion is presented on managing the data needed for materials selection, including collection, analysis, deployment, and maintenance issues.

Uptake of heavy metals by plants from airborne deposition and polluted soils

Directory of Open Access Journals (Sweden)

T. YLÄRANTA

2008-12-01

Full Text Available The concentrations of sulphur, zinc, copper, lead and cadmium in spring wheat grain and straw, Italian rye grass, timothy and lettuce were studied in a three-year field experiment conducted in southern Finland near a copper-nickel smelter and at nonpolluted control sites. A pot experiment with copper- and nickel-contaminated soils and with a nonpolluted soil as the control was conducted to determine the copper and nickel concentrations in soils phytotoxic for plants. Forty, 200 or 1000 mg of copper or nickel as cloride was added to 2 litres of soil. The nickel and copper concentrations in the shoots of oats were measured. The zinc, copper, lead, cadmium and nickel concentrations varied between different plant species and also between experimental years. Near the smelter, the uptake of nickel by different plant species was very effective, as was copper uptake by lettuce, timothy and Italian rye grass. The same applied to the zinc and cadmium uptake of plants grown on plots. Nickel, cadmium and copper were easily accumulated by plants from air deposition. In the pot experiment, high nickel concentrations in soil were more phytotoxic for oats than were high copper concentrations. In acidic soil, nickel and copper concentrations lower than 20 and 100 mg/kg of soil, respectively, decreased the dry matter yield of oats shoots. Liming clearly decreased copper and nickel phytotoxity. In the most highly contaminated soil, the addition of Cu 20 mg/kg of soil decreased the yield of oats shoots.;

Characteristics of Acupoint Selection in Treating Apoplexy

Institute of Scientific and Technical Information of China (English)

ZHAO Chao-rong; ZHANG Yan; GU Hong; ZHOU Yun; XIAO Yuan-chun

2003-01-01

Objective: To explore the characteristics of acupoint selection in the treatment of apoplexy. Method:This paper reviews and analyzes the ancient and current medical literature, and then summarizes the characteris -tics of acupoint selection in treating apoplexy. Results:Four characteristics are presented: the acupoints on the head are mostly used; the acupoints are principally selected according to the course of nerves; the acupoints of the yang meridians are usually selected; the special acupoints and empirical acupoints are often combined.Conclusion: Above principles may be adopted in the selection of acupoints to treat apoplexy.

Cryogenic Selective Surfaces

Data.gov (United States)

National Aeronautics and Space Administration — Selective surfaces have wavelength dependent emissivity/absorption. These surfaces can be designed to reflect solar radiation, while maximizing infrared emittance,...

Natural Selection and Morality

Directory of Open Access Journals (Sweden)

Alejandro Rosas

2006-12-01

Full Text Available Resumen:En este ensayo abordo los intentos, relativamente recientes, de dar una explicación de la moralidad como adaptación por selección natural. Mi exposición tiene una introducción y cuatro partes: en la primera explico en qué consiste la paradoja del altruismo biológico. En la segunda expongo la solución que apela a la selección de grupos, recientemente resurgida; la solución que presuntamente aplicó Charles Darwin cuando formuló sus reflexiones biológicas sobre la moralidad humana. En la tercera expongo la solución sociobiológica, que opta por negar que la selección natural pueda explicar directamente la moralidad humana. La moralidad se presenta más bien como opuesta a la naturaleza diseñada por selección natural. En la cuarta parte desarrollo brevemente una explicación de la moralidad como adaptación que beneficia a los individuos. No opone la moralidad a la naturaleza, ni apela a la selección de grupos. Se sirve de un mecanismo de selección que opera a través de preferencias en la interacción social.Abstract:In this essay, I address recent attempts to account for morality as an adaptation due to natural selection. After a brief introduction, my exposition has four sections. I first explain the paradox of biological altruism. Second, I explain the solution to the paradox in terms of group selection. This solution was presumably applied by Darwin himself as he discussed human morality, and it has experienced a recent revival, though it remains suspicious to most biologists. In the third section I offer a socio-biological solution that opts for denying that morality can be explained by any form of natural selection. Morality is opposed to human nature as designed by natural selection. In the fourth, I argue for an explanation in terms of individual selection. It does not oppose morality to nature, and does not need the workings of group selection; rather, it operates through the agents’ psychological preferences

Counting Possibilia

Directory of Open Access Journals (Sweden)

Alfredo Tomasetta

2010-06-01

Full Text Available Timothy Williamson supports the thesis that every possible entity necessarily exists and so he needs to explain how a possible son of Wittgenstein’s, for example, exists in our world:he exists as a merely possible object (MPO, a pure locus of potential. Williamson presents a short argument for the existence of MPOs: how many knives can be made by fitting together two blades and two handles? Four: at the most two are concrete objects, the others being merely possible knives and merely possible objects. This paper defends the idea that one can avoid reference and ontological commitment to MPOs. My proposal is that MPOs can be dispensed with by using the notion of rules of knife-making. I first present a solution according to which we count lists of instructions - selected by the rules - describing physical combinations between components. This account, however, has its own difficulties and I eventually suggest that one can find a way out by admitting possible worlds, entities which are more commonly accepted - at least by philosophers - than MPOs. I maintain that, in answering Williamson’s questions, we count classes of physically possible worlds in which the same instance of a general rule is applied.

Sexual selection in marine plankton

DEFF Research Database (Denmark)

Sichlau, Mie Hylstofte

Copepods are among the most abundant metazoans on the planet and play an important role in the marine food web. Many aspects of their ecology have consequently been studied, including details of their reproductive biology and mating behaviour. Sexual selection, the part of evolution which selects...

Molecular Components of Catalytic Selectivity

Energy Technology Data Exchange (ETDEWEB)

Somorjai, Gabor A.; Park, Jeong Y.

2008-07-02

Selectivity, that is, to produce one molecule out of many other thermodynamically feasible product molecules, is the key concept to develop 'clean manufacturing' processes that do not produce byproducts (green chemistry). Small differences in potential energy barriers for elementary reaction steps control which reaction channel is more likely to yield the desired product molecule (selectivity), instead of the overall activation energy for the reaction that controls turnover rates (activity). Recent studies have demonstrated the atomic- or molecular-level tailoring of parameters such as the surface structures of active sites that give rise to nanoparticle size and shape dependence of turnover rates and reaction selectivities. Here, we highlight seven molecular components that influence reaction selectivities. These include: surface structure, adsorbate-induced restructuring, adsorbate mobility, reaction intermediates, surface composition, charge transport, and oxidation states for model metal single crystal and colloid nanoparticle catalysts. We show examples of their functioning and describe in-situ instruments that permit us to investigate their roles in surface reactions.

Online feature selection with streaming features.

Science.gov (United States)

Wu, Xindong; Yu, Kui; Ding, Wei; Wang, Hao; Zhu, Xingquan

2013-05-01

We propose a new online feature selection framework for applications with streaming features where the knowledge of the full feature space is unknown in advance. We define streaming features as features that flow in one by one over time whereas the number of training examples remains fixed. This is in contrast with traditional online learning methods that only deal with sequentially added observations, with little attention being paid to streaming features. The critical challenges for Online Streaming Feature Selection (OSFS) include 1) the continuous growth of feature volumes over time, 2) a large feature space, possibly of unknown or infinite size, and 3) the unavailability of the entire feature set before learning starts. In the paper, we present a novel Online Streaming Feature Selection method to select strongly relevant and nonredundant features on the fly. An efficient Fast-OSFS algorithm is proposed to improve feature selection performance. The proposed algorithms are evaluated extensively on high-dimensional datasets and also with a real-world case study on impact crater detection. Experimental results demonstrate that the algorithms achieve better compactness and higher prediction accuracy than existing streaming feature selection algorithms.

Selective retina therapy (SRT)

International Nuclear Information System (INIS)

Brinkmann, R.; Birngruber, R.

2007-01-01

Selective Retina Therapy (SRT) is a new and very gentle laser method developed at the Medical Laser Center Luebeck. It is currently investigated clinically in order to treat retinal disorders associated with a decreased function of the retinal pigment epithelium (RPE). SRT is designed to selectively effect the RPE while sparing the neural retina and the photoreceptors as well as the choroid. Aim of the therapy is the rejuvenation of the RPE in the treated areas, which should ideally lead to a long term metabolic increase at the chorio-retinal junction. In contrast to conventional laser photocoagulation, which is associated with a complete thermal necrosis of the treated site, SRT completely retains full vision. This paper reviews the methods and mechanisms behind selective RPE effects and reports the first clinical results. An online dosimetry technique to visualize the ophthalmoscopically invisible effects is introduced. (orig.)

Phenomenology and treatment of selective mutism.

Science.gov (United States)

Kumpulainen, Kirsti

2002-01-01

Selective mutism is a multidimensional childhood disorder in which, according to the most recent studies, biologically mediated temperament and anxiety components seem to play a major role. Several psychotherapy methods have been reported in case studies to be useful, but the disorder is commonly seen to be resistant to change, particularly in cases of long duration. Currently, behaviour modification and other cognitive methods, together with cooperation with the family and the school personnel, are recommended in the treatment of selective mutism. Selective serotonin reuptake inhibitors and selective monoamine oxidase inhibitors have also been reported to be helpful when treating children with selective mutism. At the moment, pharmacotherapy cannot be recommended as the treatment of first choice but if other methods of treatment are not helpful, medication can be included in the treatment scheme. Comprehensive evaluation and treatment of possible primary and comorbid problems that require treatment are also essential.

Selection signatures in worldwide sheep populations.

Science.gov (United States)

Fariello, Maria-Ines; Servin, Bertrand; Tosser-Klopp, Gwenola; Rupp, Rachel; Moreno, Carole; San Cristobal, Magali; Boitard, Simon

2014-01-01

The diversity of populations in domestic species offers great opportunities to study genome response to selection. The recently published Sheep HapMap dataset is a great example of characterization of the world wide genetic diversity in sheep. In this study, we re-analyzed the Sheep HapMap dataset to identify selection signatures in worldwide sheep populations. Compared to previous analyses, we made use of statistical methods that (i) take account of the hierarchical structure of sheep populations, (ii) make use of linkage disequilibrium information and (iii) focus specifically on either recent or older selection signatures. We show that this allows pinpointing several new selection signatures in the sheep genome and distinguishing those related to modern breeding objectives and to earlier post-domestication constraints. The newly identified regions, together with the ones previously identified, reveal the extensive genome response to selection on morphology, color and adaptation to new environments.

Apparent directional selection by biased pleiotropic mutation.

Science.gov (United States)

Tanaka, Yoshinari

2010-07-01

Pleiotropic effects of deleterious mutations are considered to be among the factors responsible for genetic constraints on evolution by long-term directional selection acting on a quantitative trait. If pleiotropic phenotypic effects are biased in a particular direction, mutations generate apparent directional selection, which refers to the covariance between fitness and the trait owing to a linear association between the number of mutations possessed by individuals and the genotypic values of the trait. The present analysis has shown how the equilibrium mean value of the trait is determined by a balance between directional selection and biased pleiotropic mutations. Assuming that genes act additively both on the trait and on fitness, the total variance-standardized directional selection gradient was decomposed into apparent and true components. Experimental data on mutation bias from the bristle traits of Drosophila and life history traits of Daphnia suggest that apparent selection explains a small but significant fraction of directional selection pressure that is observed in nature; the data suggest that changes induced in a trait by biased pleiotropic mutation (i.e., by apparent directional selection) are easily compensated for by (true) directional selection.

Burglar Target Selection

Science.gov (United States)

Townsley, Michael; Bernasco, Wim; Ruiter, Stijn; Johnson, Shane D.; White, Gentry; Baum, Scott

2015-01-01

Objectives: This study builds on research undertaken by Bernasco and Nieuwbeerta and explores the generalizability of a theoretically derived offender target selection model in three cross-national study regions. Methods: Taking a discrete spatial choice approach, we estimate the impact of both environment- and offender-level factors on residential burglary placement in the Netherlands, the United Kingdom, and Australia. Combining cleared burglary data from all study regions in a single statistical model, we make statistical comparisons between environments. Results: In all three study regions, the likelihood an offender selects an area for burglary is positively influenced by proximity to their home, the proportion of easily accessible targets, and the total number of targets available. Furthermore, in two of the three study regions, juvenile offenders under the legal driving age are significantly more influenced by target proximity than adult offenders. Post hoc tests indicate the magnitudes of these impacts vary significantly between study regions. Conclusions: While burglary target selection strategies are consistent with opportunity-based explanations of offending, the impact of environmental context is significant. As such, the approach undertaken in combining observations from multiple study regions may aid criminology scholars in assessing the generalizability of observed findings across multiple environments. PMID:25866418

Decommissioning strategy selection

International Nuclear Information System (INIS)

Warnecke, E.

2005-01-01

At the end of their useful life nuclear facilities have to be decommissioned. The strategy selection on how to decommission a facility is a highly important decision at the very beginning of decommissioning planning. Basically, a facility may be subject to (a) immediate dismantling; (b) deferred dismantling after a period of ''safe enclosure'' or (c) entombment where a facility is turned into a near surface disposal facility. The first two strategies are normally applied. The third one may be accepted in countries without significant nuclear activities and hence without disposal facilities for radioactive waste. A large number of factors has to be taken into account when a decision on the decommissioning strategy is being made. Many of the factors cannot be quantified. They may be qualitative or subject to public opinion which may change with time. At present, a trend can be observed towards immediate dismantling of nuclear facilities, mainly because it is associated with less uncertainty, less local impact, a better public acceptance, and the availability of operational expertise and know how. A detailed evaluation of the various factors relevant to strategy selection and a few examples showing the situation regarding decommissioning strategy in a number of selected countries are presented in the following article. (orig.)

Selection of Phototransduction Genes in Homo sapiens.

Science.gov (United States)

Christopher, Mark; Scheetz, Todd E; Mullins, Robert F; Abràmoff, Michael D

2013-08-13

We investigated the evidence of recent positive selection in the human phototransduction system at single nucleotide polymorphism (SNP) and gene level. SNP genotyping data from the International HapMap Project for European, Eastern Asian, and African populations was used to discover differences in haplotype length and allele frequency between these populations. Numeric selection metrics were computed for each SNP and aggregated into gene-level metrics to measure evidence of recent positive selection. The level of recent positive selection in phototransduction genes was evaluated and compared to a set of genes shown previously to be under recent selection, and a set of highly conserved genes as positive and negative controls, respectively. Six of 20 phototransduction genes evaluated had gene-level selection metrics above the 90th percentile: RGS9, GNB1, RHO, PDE6G, GNAT1, and SLC24A1. The selection signal across these genes was found to be of similar magnitude to the positive control genes and much greater than the negative control genes. There is evidence for selective pressure in the genes involved in retinal phototransduction, and traces of this selective pressure can be demonstrated using SNP-level and gene-level metrics of allelic variation. We hypothesize that the selective pressure on these genes was related to their role in low light vision and retinal adaptation to ambient light changes. Uncovering the underlying genetics of evolutionary adaptations in phototransduction not only allows greater understanding of vision and visual diseases, but also the development of patient-specific diagnostic and intervention strategies.

Model selection in periodic autoregressions

NARCIS (Netherlands)

Ph.H.B.F. Franses (Philip Hans); R. Paap (Richard)

1994-01-01

textabstractThis paper focuses on the issue of period autoagressive time series models (PAR) selection in practice. One aspect of model selection is the choice for the appropriate PAR order. This can be of interest for the valuation of economic models. Further, the appropriate PAR order is important

Conditional control in visual selection

NARCIS (Netherlands)

van Zoest, Wieske; Van der Stigchel, Stefan; Donk, Mieke

2017-01-01

Attention and eye movements provide a window into the selective processing of visual information. Evidence suggests that selection is influenced by various factors and is not always under the strategic control of the observer. The aims of this tutorial review are to give a brief introduction to eye

Asbestos: selected cancers

National Research Council Canada - National Science Library

Institute of Medicine; Board on Population Health and Public Health Practice; Institute of Medicine; National Academy of Sciences

2006-01-01

...: Selected Health Effects. This committee was charged with addressing whether asbestos exposure is causally related to adverse health consequences in addition to asbestosis, mesothelioma, and lung cancer. Asbestos...

Selectively reflective transparent sheets

Science.gov (United States)

Waché, Rémi; Florescu, Marian; Sweeney, Stephen J.; Clowes, Steven K.

2015-08-01

We investigate the possibility to selectively reflect certain wavelengths while maintaining the optical properties on other spectral ranges. This is of particular interest for transparent materials, which for specific applications may require high reflectivity at pre-determined frequencies. Although there exist currently techniques such as coatings to produce selective reflection, this work focuses on new approaches for mass production of polyethylene sheets which incorporate either additives or surface patterning for selective reflection between 8 to 13 μ m. Typical additives used to produce a greenhouse effect in plastics include particles such as clays, silica or hydroxide materials. However, the absorption of thermal radiation is less efficient than the decrease of emissivity as it can be compared with the inclusion of Lambertian materials. Photonic band gap engineering by the periodic structuring of metamaterials is known in nature for producing the vivid bright colors in certain organisms via strong wavelength-selective reflection. Research to artificially engineer such structures has mainly focused on wavelengths in the visible and near infrared. However few studies to date have been carried out to investigate the properties of metastructures in the mid infrared range even though the patterning of microstructure is easier to achieve. We present preliminary results on the diffuse reflectivity using FDTD simulations and analyze the technical feasibility of these approaches.

Supplier Selection by Coupling-Attribute Combinatorial Analysis

Directory of Open Access Journals (Sweden)

Xinyu Sun

2017-01-01

Full Text Available Increasing reliance on outsourcing has made supplier selection a critical success factor for a supply chain/network. In addition to cost, the synergy among product components and supplier selection criteria should be considered holistically during the supplier selection process. This paper shows this synergy using coupled-attribute analysis. The key coupling attributes, including total cost, quality, delivery reliability, and delivery lead time of the final product, are identified and formulated. A max-max model is designed to assist the selection of the optional combination of suppliers. The results are compared with the individual supplier selection. Management insights are also discussed.

Detection of selection signatures of population-specific genomic regions selected during domestication process in Jinhua pigs.

Science.gov (United States)

Li, Zhengcao; Chen, Jiucheng; Wang, Zhen; Pan, Yuchun; Wang, Qishan; Xu, Ningying; Wang, Zhengguang

2016-12-01

Chinese pigs have been undergoing both natural and artificial selection for thousands of years. Jinhua pigs are of great importance, as they can be a valuable model for exploring the genetic mechanisms linked to meat quality and other traits such as disease resistance, reproduction and production. The purpose of this study was to identify distinctive footprints of selection between Jinhua pigs and other breeds utilizing genome-wide SNP data. Genotyping by genome reducing and sequencing was implemented in order to perform cross-population extended haplotype homozygosity to reveal strong signatures of selection for those economically important traits. This work was performed at a 2% genome level, which comprised 152 006 SNPs genotyped in a total of 517 individuals. Population-specific footprints of selective sweeps were searched for in the genome of Jinhua pigs using six native breeds and three European breeds as reference groups. Several candidate genes associated with meat quality, health and reproduction, such as GH1, CRHR2, TRAF4 and CCK, were found to be overlapping with the significantly positive outliers. Additionally, the results revealed that some genomic regions associated with meat quality, immune response and reproduction in Jinhua pigs have evolved directionally under domestication and subsequent selections. The identified genes and biological pathways in Jinhua pigs showed different selection patterns in comparison with the Chinese and European breeds. © 2016 Stichting International Foundation for Animal Genetics.