3D additive-manufactured nanocomposite magnetic scaffolds: Effect of the application mode of a time-dependent magnetic field on hMSCs behavior

Directory of Open Access Journals (Sweden)

Ugo D'Amora

2017-09-01

The aim of the present study was to analyze the effect of the application mode of a time-dependent magnetic field on the behavior of human mesenchymal stem cells (hMSCs seeded on 3D additive-manufactured poly(ɛ-caprolactone/iron-doped hydroxyapatite (PCL/FeHA nanocomposite scaffolds.

Fast DRR generation for 2D to 3D registration on GPUs

Energy Technology Data Exchange (ETDEWEB)

Tornai, Gabor Janos; Cserey, Gyoergy [Faculty of Information Technology, Pazmany Peter Catholic University, Prater u. 50/a, H-1083, Budapest (Hungary); Pappas, Ion [General Electric Healthcare, Akron u. 2, H-2040, Budaoers (Hungary)

2012-08-15

Purpose: The generation of digitally reconstructed radiographs (DRRs) is the most time consuming step on the CPU in intensity based two-dimensional x-ray to three-dimensional (CT or 3D rotational x-ray) medical image registration, which has application in several image guided interventions. This work presents optimized DRR rendering on graphical processor units (GPUs) and compares performance achievable on four commercially available devices. Methods: A ray-cast based DRR rendering was implemented for a 512 Multiplication-Sign 512 Multiplication-Sign 72 CT volume. The block size parameter was optimized for four different GPUs for a region of interest (ROI) of 400 Multiplication-Sign 225 pixels with different sampling ratios (1.1%-9.1% and 100%). Performance was statistically evaluated and compared for the four GPUs. The method and the block size dependence were validated on the latest GPU for several parameter settings with a public gold standard dataset (512 Multiplication-Sign 512 Multiplication-Sign 825 CT) for registration purposes. Results: Depending on the GPU, the full ROI is rendered in 2.7-5.2 ms. If sampling ratio of 1.1%-9.1% is applied, execution time is in the range of 0.3-7.3 ms. On all GPUs, the mean of the execution time increased linearly with respect to the number of pixels if sampling was used. Conclusions: The presented results outperform other results from the literature. This indicates that automatic 2D to 3D registration, which typically requires a couple of hundred DRR renderings to converge, can be performed quasi on-line, in less than a second or depending on the application and hardware in less than a couple of seconds. Accordingly, a whole new field of applications is opened for image guided interventions, where the registration is continuously performed to match the real-time x-ray.

Isobaric analogue states of 73Ge via 72Ge(3He,d)73As reaction

International Nuclear Information System (INIS)

Ramaswamy, C.R.; Puttaswamy, N.G.; Sarma, N.

1974-01-01

The 72 Ge( 3 He,d) 73 As reaction has been studied at 20 MeV incident 3 He energy using an MP tandem and a multigap spectrograph. The energy spectrum of deuterons in the region between 9 to 10.5 MeV excitation energy of 73 As shows analogue states corresponding to G.S., 570, 673, 805, 900, 1050, and 1350 KeV states of 73 Ge. Angular distributions for the analogue states and 1-values of the transferred protons are extracted. The results are compared with available data on the levels of 73 Ge. (author)

Extra dimensions: 3d and time in pdf documentation

Energy Technology Data Exchange (ETDEWEB)

Graf, N A [Stanford Linear Accelerator Center, Menlo Park, CA, 94025 (United States)], E-mail: Norman.Graf@slac.stanford.edu

2008-07-15

High energy physics is replete with multi-dimensional information which is often poorly represented by the two dimensions of presentation slides and print media. Past efforts to disseminate such information to a wider audience have failed for a number of reasons, including a lack of standards which are easy to implement and have broad support. Adobe's Portable Document Format (PDF) has in recent years become the de facto standard for secure, dependable electronic information exchange. It has done so by creating an open format, providing support for multiple platforms and being reliable and extensible. By providing support for the ECMA standard Universal 3D (U3D) file format in its free Adobe Reader software, Adobe has made it easy to distribute and interact with 3D content. By providing support for scripting and animation, temporal data can also be easily distributed to a wide audience. In this talk, we present examples of HEP applications which take advantage of this functionality. We demonstrate how 3D detector elements can be documented, using either CAD drawings or other sources such as GEANT visualizations as input. Using this technique, higher dimensional data, such as LEGO plots or time-dependent information can be included in PDF files. In principle, a complete event display, with full interactivity, can be incorporated into a PDF file. This would allow the end user not only to customize the view and representation of the data, but to access the underlying data itself.

Extra dimensions: 3d and time in pdf documentation

International Nuclear Information System (INIS)

Graf, N A

2008-01-01

High energy physics is replete with multi-dimensional information which is often poorly represented by the two dimensions of presentation slides and print media. Past efforts to disseminate such information to a wider audience have failed for a number of reasons, including a lack of standards which are easy to implement and have broad support. Adobe's Portable Document Format (PDF) has in recent years become the de facto standard for secure, dependable electronic information exchange. It has done so by creating an open format, providing support for multiple platforms and being reliable and extensible. By providing support for the ECMA standard Universal 3D (U3D) file format in its free Adobe Reader software, Adobe has made it easy to distribute and interact with 3D content. By providing support for scripting and animation, temporal data can also be easily distributed to a wide audience. In this talk, we present examples of HEP applications which take advantage of this functionality. We demonstrate how 3D detector elements can be documented, using either CAD drawings or other sources such as GEANT visualizations as input. Using this technique, higher dimensional data, such as LEGO plots or time-dependent information can be included in PDF files. In principle, a complete event display, with full interactivity, can be incorporated into a PDF file. This would allow the end user not only to customize the view and representation of the data, but to access the underlying data itself

Time-dependent CP-violation measurements in $B^0 \\to D^+D^–$ decays at LHCb

CERN Multimedia

Bel, Lennaert

2016-01-01

Overconstraining the unitarity triangle is a key goal of LHCb. The excellent time resolution of the detector lends itself to high precision time dependent CP violation measurements. CP observables in $B^0 \\to D^{+}D^{‐}$ decays are of great interest as they have the potential to be sensitive to new physics contributions. There is a long¬‐existing tension between results from BaBar and Belle on $B^0 \\to D^{+}D^{‐}$. We present results on these CP observables with the full Run 1 dataset.

The Response of Ω-Loop D Dynamics to Truncation of Trimethyllysine 72 of Yeast Iso-1-cytochrome c Depends on the Nature of Loop Deformation

Science.gov (United States)

McClelland, Levi J.; Seagraves, Sean M.; Khan, Khurshid Alam; Cherney, Melisa M.; Bandi, Swati; Culbertson, Justin E.; Bowler, Bruce E.

2015-01-01

Trimethyllysine 72 (tmK72) has been suggested to play a role in sterically constraining the heme crevice dynamics of yeast iso-1-cytochrome c mediated by the Ω-loop D cooperative substructure (residues 70 to 85). A tmK72A mutation causes a gain in peroxidase activity, a function of cytochrome c that is important early in apoptosis. More than one higher energy state is accessible for the Ω-loop D substructure via tier 0 dynamics. Two of these are alkaline conformers mediated by Lys73 and Lys79. In the current work, the effect of the tmK72A mutation on the thermodynamic and kinetic properties of wild type iso-1-cytochrome c (yWT versus WT*) and on variants carrying a K73H mutation (yWT/K73H versus WT*/K73H) is studied. Whereas the tmK72A mutation confers increased peroxidase activity in wild type yeast iso-1-cytochrome c and increased dynamics for formation of a previously studied His79-heme alkaline conformer, the tmK72A mutation speeds return of the His73-heme alkaline conformer to the native state through destabilization of the His73-heme alkaline conformer relative to the native conformer. These opposing behaviors demonstrate that the response of the dynamics of a protein substructure to mutation depends on the nature of the perturbation to the substructure. For a protein substructure which mediates more than one function of a protein through multiple non-native structures, a mutation could change the partitioning between these functions. The current results suggest that the tier 0 dynamics of Ω-loop D that mediates peroxidase activity has similarities to the tier 0 dynamics required to form the His79-heme alkaline conformer. PMID:25948392

TDTORT: Time-Dependent, 3-D, Discrete Ordinates, Neutron Transport Code System with Delayed Neutrons

International Nuclear Information System (INIS)

2002-01-01

1 - Description of program or function: TDTORT solves the time-dependent, three-dimensional neutron transport equation with explicit representation of delayed neutrons to estimate the fission yield from fissionable material transients. This release includes a modified version of TORT from the C00650MFMWS01 DOORS3.1 code package plus the time-dependent TDTORT code. GIP is also included for cross-section preparation. TORT calculates the flux or fluence of particles due to particles incident upon the system from extraneous sources or generated internally as a result of interaction with the system in two- or three-dimensional geometric systems. The principle application is to the deep-penetration transport of neutrons and photons. Reactor eigenvalue problems can also be solved. Numerous printed edits of the results are available, and results can be transferred to output files for subsequent analysis. TDTORT reads ANISN-format cross-section libraries, which are not included in the package. Users may choose from several available in RSICC's data library collection which can be identified by the keyword 'ANISN FORMAT'. 2 - Methods:The time-dependent spatial flux is expressed as a product of a space-, energy-, and angle-dependent shape function, which is usually slowly varying in time and a purely time-dependent amplitude function. The shape equation is solved for the shape using TORT; and the result is used to calculate the point kinetics parameters (e.g., reactivity) by using their inner product definitions, which are then used to solve the time-dependent amplitude and precursor equations. The amplitude function is calculated by solving the kinetics equations using the LSODE solver. When a new shape calculation is needed, the flux is calculated using the newly computed amplitude function. The Boltzmann transport equation is solved using the method of discrete ordinates to treat the directional variable and weighted finite-difference methods, in addition to Linear Nodal

A 3D coarse-mesh time dependent code for nuclear reactor kinetic calculations

International Nuclear Information System (INIS)

Montagnini, B.; Raffaelli, P.; Sumini, M.; Zardini, D.M.

1996-01-01

A course-mesh code for time-dependent multigroup neutron diffusion calculation based on a direct integration scheme for the time dependence and a low order nodal flux expansion approximation for the space variables has been implemented as a fast tool for transient analysis. (Author)

Time-Dependent Neutral Particle Transport Benchmarks in Two and Three Dimensions

International Nuclear Information System (INIS)

Barry D. Ganapol

2007-01-01

The main objective of NEER grant was to generate highly accurate 2D and 3D time-dependent neutral particle intensity maps from 3D pulsed wire sources through integration of the analytical representation of a time-dependent point source

Perceptual Real-Time 2D-to-3D Conversion Using Cue Fusion.

Science.gov (United States)

Leimkuhler, Thomas; Kellnhofer, Petr; Ritschel, Tobias; Myszkowski, Karol; Seidel, Hans-Peter

2018-06-01

We propose a system to infer binocular disparity from a monocular video stream in real-time. Different from classic reconstruction of physical depth in computer vision, we compute perceptually plausible disparity, that is numerically inaccurate, but results in a very similar overall depth impression with plausible overall layout, sharp edges, fine details and agreement between luminance and disparity. We use several simple monocular cues to estimate disparity maps and confidence maps of low spatial and temporal resolution in real-time. These are complemented by spatially-varying, appearance-dependent and class-specific disparity prior maps, learned from example stereo images. Scene classification selects this prior at runtime. Fusion of prior and cues is done by means of robust MAP inference on a dense spatio-temporal conditional random field with high spatial and temporal resolution. Using normal distributions allows this in constant-time, parallel per-pixel work. We compare our approach to previous 2D-to-3D conversion systems in terms of different metrics, as well as a user study and validate our notion of perceptually plausible disparity.

BRDF-dependent accuracy of array-projection-based 3D sensors.

Science.gov (United States)

Heist, Stefan; Kühmstedt, Peter; Tünnermann, Andreas; Notni, Gunther

2017-03-10

In order to perform high-speed three-dimensional (3D) shape measurements with structured light systems, high-speed projectors are required. One possibility is an array projector, which allows pattern projection at several tens of kilohertz by switching on and off the LEDs of various slide projectors. The different projection centers require a separate analysis, as the intensity received by the cameras depends on the projection direction and the object's bidirectional reflectance distribution function (BRDF). In this contribution, we investigate the BRDF-dependent errors of array-projection-based 3D sensors and propose an error compensation process.

Monoclonal antibody OKB7, which identifies the 14OKd complement receptor type 2 (CR2), also identifies a 72Kd secreted fragment of CR2 that contains the C3d-binding site

International Nuclear Information System (INIS)

Myones, B.L.; Ross, G.D.

1986-01-01

CR 2 is a 140-145Kd glycoprotein expressed on B lymphocytes which binds both C3d and Epstein-Barr virus (EBV). OKB7, an IgG/sub 2a/ monoclonal antibody to CR 2 , blocks C3d and EBV binding, while HB-5, another monoclonal IgG/sub 2a/ anti-CR 2 , does not. A 72Kd C3d-binding glycoprotein (gp72), isolated from Raji cell media, was previously thought to be CR 2 because a polyclonal rabbit anti-gp72 inhibited EC3d rosettes. ELISA assay demonstrated that OKB7, but not HB-5, bound to purified gp72 fixed to microtiter wells. Insoluble and soluble gp72 blocked Raji cell uptake of 125 I-labeled OKB7, but not labeled anti-B2 or HB-5. Rabbit anti-gp72 immunoprecipitated bands at 140Kd and 72Kd from 125 I-labelled and solubilized B cell membranes. Culture media from Raji cells grown in the presence 3 H-labeled amino acids was sequentially immunoprecipitated by irrelevant antibody, OKB7, and HB-5. A single 72Kd radiolabeled band was demonstrated only with OKB7, and this was identical to that produced by the immunoprecipitation of 125 I-labeled gp72 with rabbit anti-gp72. Thus, OKB7, which identifies the 140Kd CR 2 molecule, also identifies a 72Kd shed fragment of CR 2 isolated from Raji cell media, which contains the C3d-binding site

CEXE INCEXE, 1 Group 3-D Time-Dependent Xe Oscillations in X-Y-Z Geometry with Feedback

International Nuclear Information System (INIS)

Kern, R.; Pacino, S.

1973-01-01

1 - Description of problem or function: CEXE solves the three- dimensional xyz time-dependent xenon spatial oscillation problem using a modified one energy group theory and a nodal representation. 2 - Method of solution: CEXE solves for the spatial neutron source distribution with coupled Doppler and moderator temperature feedbacks. The time dependence of the iodine and xenon concentrations are based on the assumption of constant power during each time-step interval. 3 - Restrictions on the complexity of the problem: Maximum reactor core size representation is restricted to a nodal configuration of 19 x 19 x 10 in the x, y, z directions, respectively

1,25-Dihydroxyvitamin D3 induces biphasic NF-κB responses during HL-60 leukemia cells differentiation through protein induction and PI3K/Akt-dependent phosphorylation/degradation of IκB

International Nuclear Information System (INIS)

Tse, A.K.-W.; Wan, C.-K.; Shen, X.-L.; Zhu, G.-Y.; Cheung, H.-Y.; Yang, M.; Fong, W.-F.

2007-01-01

1,25-Dihydroxyvitamin D 3 (VD 3 ) induces differentiation in a number of leukemia cell lines and under various conditions is able to either stimulate or inhibit nuclear factor kappa B (NF-κB) activity. Here we report a time-dependent biphasic regulation of NF-κB in VD 3 -treated HL-60 leukemia cells. After VD 3 treatment there was an early ∼ 4 h suppression and a late 8-72 h prolonged reactivation of NF-κB. The reactivation of NF-κB was concomitant with increased IKK activities, IKK-mediated IκBα phosphorylation, p65 phosphorylation at residues S276 and S536, p65 nuclear translocation and p65 recruitment to the NF-κB/vitamin D responsive element promoters. In parallel with NF-κB stimulation, there was an up-regulation of NF-κB controlled inflammatory and anti-apoptotic genes such as TNFα, IL-1β and Bcl-xL. VD 3 -triggered reactivation of NF-κB was associated with PI3K/Akt phosphorylation. PI3K/Akt antagonists suppressed VD 3 -stimulated IκBα phosphorylation as well as NF-κB-controlled gene expression. The early ∼ 4 h VD 3 -mediated NF-κB suppression coincided with a prolonged increase of IκBα protein which require de novo protein synthesis, lasted for as least 72 h and was insensitive to MAPK, IKK or PI3K/Akt inhibitors. Our data suggest a novel biphasic regulation of NF-κB in VD 3 -treated leukemia cells and our results may have provided the first molecular explanation for the contradictory observations reported on VD 3 -mediated immune-regulation

UV dependent vitamin D syntheses. UV exposure time balancing for optimum production of the vitamins D3 status in the human body. Final report

International Nuclear Information System (INIS)

Knuschke, P.; Lehmann, B.; Pueschel, A.; Roensch, H.

2012-01-01

UV-dependent vitamin D 3 synthesis - balancing of UV exposure time and the production of an optimal vitamin D 3 status in men The adverse health effects on human skin and eyes by UV radiation have been well known for years. They are known to the public, too. Increased exposures by the UV-B fraction of solar radiation cause e.g. sun burn as an acute skin reaction or an increased risk on skin cancer as a chronic effect. Radiation of the same spectral UV-B range is necessary to induce the essential vitamin D metabolism in men. The UV-induced vitamin D synthesis in the skin supplies the body with more than 90 % while our typical nutrition contributes no more than 10 %. These photobiological effects are diametrically opposed. Therefore, up to now there are contradictory recommendations to the public concerning the health effects of solar UV exposure. The aim of this research project was to evaluate the quantitative and qualitative relations of UV exposure and the vitamin D status in men taking into account different conditions in the population. In result, well-balanced recommendations on optimal UV exposures for the different fractions of the population should be elaborated, realizing health protection aspects against detrimental UV effects. A literature survey (updated in 2011) summarizes the current knowledge on the vitamin D metabolism, on the effects of the hormone vitamin D and on the stage of the current discussion on the optimal vitamin D status. In a number of studies of this project the effects of UV exposure on the vitamin D status (25OH-vitamin D 3 und 1,25OH-vitamin D 3 ) were investigated. Exposure parameters were the photobiologically effective UV dose (with respect to the minimal erythema dose MED = individual sun burn dose in each investigated volunteer) and the extent of the exposed skin area: face and hands (like everyday conditions) or whole body respectively. Serial UV exposures were applied by natural solar UV radiation or by simulated solar

3D+time acquisitions of 3D cell culture by means of lens-free tomographic microscopy

Science.gov (United States)

Berdeu, Anthony; Laperrousaz, Bastien; Bordy, Thomas; Morales, S.; Gidrol, Xavier; Picollet-D'hahan, Nathalie; Allier, Cédric

2018-02-01

We propose a three-dimensional (3D) imaging platform based on lens-free microscopy to perform multi-angle acquisitions on 3D cell cultures embedded in extracellular matrix (ECM). We developed algorithms based on the Fourier diffraction theorem to perform fully 3D reconstructions of biological samples and we adapted the lens-free microscope to incubator conditions. Here we demonstrate for the first time, 3D+time lens-free acquisitions of 3D cell culture over 8 days directly into the incubator. The 3D reconstructed volume is as large as 5 mm3 and provides a unique way to observe in the same 3D cell culture experiment multiple cell migration strategies. Namely, in a 3D cell culture of prostate epithelial cells embedded within a Matrigel® matrix, we are able to distinguish single cell 'leaders', migration of cell clusters, migration of large aggregates of cells, and also close-gap and large-scale branching. In addition, we observe long-scale 3D deformations of the ECM that modify the geometry of the 3D cell culture. Interestingly, we also observed the opposite, i.e. we found that large aggregates of cells may deform the ECM by generating traction forces over very long distances. In sum we put forward a novel 3D lens-free microscopy tomographic technique to study the single and collective cell migrations, the cell-to-cell interactions and the cell-to-matrix interactions.

Monoclonal antibody OKB7, which identifies the 14OKd complement receptor type 2 (CR/sub 2/), also identifies a 72Kd secreted fragment of CR/sub 2/ that contains the C3d-binding site

Energy Technology Data Exchange (ETDEWEB)

Myones, B.L.; Ross, G.D.

1986-03-05

CR/sub 2/ is a 140-145Kd glycoprotein expressed on B lymphocytes which binds both C3d and Epstein-Barr virus (EBV). OKB7, an IgG/sub 2a/ monoclonal antibody to CR/sub 2/, blocks C3d and EBV binding, while HB-5, another monoclonal IgG/sub 2a/ anti-CR/sub 2/, does not. A 72Kd C3d-binding glycoprotein (gp72), isolated from Raji cell media, was previously thought to be CR/sub 2/ because a polyclonal rabbit anti-gp72 inhibited EC3d rosettes. ELISA assay demonstrated that OKB7, but not HB-5, bound to purified gp72 fixed to microtiter wells. Insoluble and soluble gp72 blocked Raji cell uptake of /sup 125/I-labeled OKB7, but not labeled anti-B2 or HB-5. Rabbit anti-gp72 immunoprecipitated bands at 140Kd and 72Kd from /sup 125/I-labelled and solubilized B cell membranes. Culture media from Raji cells grown in the presence /sup 3/H-labeled amino acids was sequentially immunoprecipitated by irrelevant antibody, OKB7, and HB-5. A single 72Kd radiolabeled band was demonstrated only with OKB7, and this was identical to that produced by the immunoprecipitation of /sup 125/I-labeled gp72 with rabbit anti-gp72. Thus, OKB7, which identifies the 140Kd CR/sub 2/ molecule, also identifies a 72Kd shed fragment of CR/sub 2/ isolated from Raji cell media, which contains the C3d-binding site.

Measurement of the Time-Dependent CP Asymmetry of Partially Reconstructed B0 to D*+D*- Decays

Energy Technology Data Exchange (ETDEWEB)

Lees, J. P.

2012-08-13

We present a new measurement of the time-dependent CP asymmetry of B{sup 0} {yields}D*{sup +}D*{sup -} decays using (471 {+-} 5) million B{bar B} pairs collected with the BABAR detector at the PEP-II B Factory at the SLAC National Accelerator Laboratory. Using the technique of partial reconstruction, we measure the time-dependent CP asymmetry parameters S = -0.34 {+-} 0.12 {+-} 0.05 and C = +0:15 {+-} 0.09 {+-} 0.04. Using the value for the CP-odd fraction R{perpendicular} = 0.158 {+-} 0.028 {+-} 0.006, previously measured by BABAR with fully reconstructed B{sup 0} {yields} D{sup *+}D{sup *-} events, we extract the CP-even components S{sub +} = -0.49 {+-} 0.18 {+-} 0.07 {+-} 0.04 and C{sub +} = +0.15 {+-} 0.09 {+-} 0.04. In each case, the first uncertainty is statistical and the second is systematic; the third uncertainty on S{sub +} is the contribution from the uncertainty on R{perpendicular}. The measured value of the CP-even component S{sub +} is consistent with the value of sin 2{beta} measured in b {yields} (c{bar c})s transitions, and with the Standard Model expectation of small penguin contributions.

A time-dependent neutron transport method of characteristics formulation with time derivative propagation

Energy Technology Data Exchange (ETDEWEB)

Hoffman, Adam J., E-mail: adamhoff@umich.edu; Lee, John C., E-mail: jcl@umich.edu

2016-02-15

A new time-dependent Method of Characteristics (MOC) formulation for nuclear reactor kinetics was developed utilizing angular flux time-derivative propagation. This method avoids the requirement of storing the angular flux at previous points in time to represent a discretized time derivative; instead, an equation for the angular flux time derivative along 1D spatial characteristics is derived and solved concurrently with the 1D transport characteristic equation. This approach allows the angular flux time derivative to be recast principally in terms of the neutron source time derivatives, which are approximated to high-order accuracy using the backward differentiation formula (BDF). This approach, called Source Derivative Propagation (SDP), drastically reduces the memory requirements of time-dependent MOC relative to methods that require storing the angular flux. An SDP method was developed for 2D and 3D applications and implemented in the computer code DeCART in 2D. DeCART was used to model two reactor transient benchmarks: a modified TWIGL problem and a C5G7 transient. The SDP method accurately and efficiently replicated the solution of the conventional time-dependent MOC method using two orders of magnitude less memory.

A time-dependent neutron transport method of characteristics formulation with time derivative propagation

International Nuclear Information System (INIS)

Hoffman, Adam J.; Lee, John C.

2016-01-01

A new time-dependent Method of Characteristics (MOC) formulation for nuclear reactor kinetics was developed utilizing angular flux time-derivative propagation. This method avoids the requirement of storing the angular flux at previous points in time to represent a discretized time derivative; instead, an equation for the angular flux time derivative along 1D spatial characteristics is derived and solved concurrently with the 1D transport characteristic equation. This approach allows the angular flux time derivative to be recast principally in terms of the neutron source time derivatives, which are approximated to high-order accuracy using the backward differentiation formula (BDF). This approach, called Source Derivative Propagation (SDP), drastically reduces the memory requirements of time-dependent MOC relative to methods that require storing the angular flux. An SDP method was developed for 2D and 3D applications and implemented in the computer code DeCART in 2D. DeCART was used to model two reactor transient benchmarks: a modified TWIGL problem and a C5G7 transient. The SDP method accurately and efficiently replicated the solution of the conventional time-dependent MOC method using two orders of magnitude less memory.

Contrast-enhanced MR angiography of the carotid artery using 3D time-resolved imaging of contrast kinetics. Comparison with real-time fluoroscopic triggered 3D-elliptical centric view ordering

International Nuclear Information System (INIS)

Naganawa, Shinji; Koshikawa, Tokiko; Fukatsu, Hiroshi; Sakurai, Yasuo; Ishiguchi, Tsuneo; Ishigaki, Takeo; Ichinose, Nobuyasu

2001-01-01

The purpose of this study was to evaluate contrast-enhanced MR angiography using the 3D time-resolved imaging of contrast kinetics technique (3D-TRICKS) by direct comparison with the fluoroscopic triggered 3D-elliptical centric view ordering (3D-ELLIP) technique. 3D-TRICKS and 3D-ELLIP were directly compared on a 1.5-Tesla MR unit using the same spatial resolution and matrix. In 3D-TRICKS, the central part of the k-space is updated more frequently than the peripheral part of the k-space, which is divided in the slice-encoding direction. The carotid arteries were imaged using 3D-TRICKS and 3D-ELLIP sequentially in 14 patients. Temporal resolution was 12 sec for 3D-ELLIP and 6 sec for 3D-TRICKS. The signal-to-noise ratio (S/N) of the common carotid artery was measured, and the quality of MIP images was then scored in terms of venous overlap and blurring of vessel contours. No significant difference in mean S/N was seen between the two methods. Significant venous overlap was not seen in any of the patients examined. Moderate blurring of vessel contours was noted on 3D-TRICKS in five patients and on 3D-ELLIP in four patients. Blurring in the slice-encoding direction was slightly more pronounced in 3D-TRICKS. However, qualitative analysis scores showed no significant differences. When the spatial resolution of the two methods was identical, the performance of 3D-TRICKS was found to be comparable in static visualization of the carotid arteries with 3D-ELLIP, although blurring in the slice-encoding direction was slightly more pronounced in 3D-TRICKS. 3D-TRICKS is a more robust technique than 3D-ELLIP, because 3D-ELLIP requires operator-dependent fluoroscopic triggering. Furthermore, 3D-TRICKS can achieve higher temporal resolution. For the spatial resolution employed in this study, 3D-TRICKS may be the method of choice. (author)

Effective sensitivity in 3D PET: The impact of detector dead time on 3D system performance

International Nuclear Information System (INIS)

Bailey, D.L.; Jones, T.; Meikle, S.R.

1996-01-01

3D PET has higher sensitivity than 2D PET. Sensitivity is determined by two components: the geometric solid angle for detection, and the fractional dead time, i.e., the time for which the detector is unavailable for accepting events. The loss in overall sensitivity as a function of radioactivity concentration due to these factors for 3D PET has been characterized by a parameter, the effective sensitivity, which combines absolute sensitivity and noise equivalent count rates. This parameter includes scatter, system sensitivity, dead time, and random coincidence rates, and permits comparisons between different tomographs as well as the same tomograph under different conditions. Effective sensitivity decreases most rapidly for larger, open 3D tomographs. The loss in effective sensitivity with increasing count rate suggests that new faster scintillation detectors will be needed to realize the sensitivity gain of 3D PET over a wide dynamic range of radioactivity concentrations

3D Viscoelastic Traction Force Microscopy

Science.gov (United States)

Toyjanova, Jennet; Hannen, Erin; Bar-Kochba, Eyal; Darling, Eric M.; Henann, David L.; Franck, Christian

2014-01-01

Native cell-material interactions occur on materials differing in their structural composition, chemistry, and physical compliance. While the last two decades have shown the importance of traction forces during cell-material interactions, they have been almost exclusively presented on purely elastic in-vitro materials. Yet, most bodily tissue materials exhibit some level of viscoelasticity, which could play an important role in how cells sense and transduce tractions. To expand the realm of cell traction measurements and to encompass all materials from elastic to viscoelastic, this paper presents a general, and comprehensive approach for quantifying 3D cell tractions in viscoelastic materials. This methodology includes the experimental characterization of the time-dependent material properties for any viscoelastic material with the subsequent mathematical implementation of the determined material model into a 3D traction force microscopy (3D TFM) framework. Utilizing this new 3D viscoelastic TFM (3D VTFM) approach, we quantify the influence of viscosity on the overall material traction calculations and quantify the error associated with omitting time-dependent material effects, as is the case for all other TFM formulations. We anticipate that the 3D VTFM technique will open up new avenues of cell-material investigations on even more physiologically relevant time-dependent materials including collagen and fibrin gels. PMID:25170569

On time-dependent Hamiltonian realizations of planar and nonplanar systems

Science.gov (United States)

Esen, Oğul; Guha, Partha

2018-04-01

In this paper, we elucidate the key role played by the cosymplectic geometry in the theory of time dependent Hamiltonian systems in 2 D. We generalize the cosymplectic structures to time-dependent Nambu-Poisson Hamiltonian systems and corresponding Jacobi's last multiplier for 3 D systems. We illustrate our constructions with various examples.

Time-lapse seismic - repeatability versus usefulness and 2D versus 3D

Science.gov (United States)

Landro, M.

2017-12-01

Time-lapse seismic has developed rapidly over the past decades, especially for monitoring of oil and gas reservoirs and subsurface storage of CO2. I will review and discuss some of the critical enabling factors for the commercial success of this technology. It was early realized that how well we are able to repeat our seismic experiment is crucial. However, it is always a question of detectability versus repeatability. For marine seismic, there are several factors limiting the repeatability: Weather conditions, positioning of sources and receivers and so on. I will discuss recent improvements in both acquisition and processing methods over the last decade. It is well known that repeated 3D seismic data is the most accurate tool for reservoir monitoring purposes. However, several examples show that 2D seismic data may be used for monitoring purposes despite lower repeatability. I will use examples from an underground blow out in the North Sea, and repeated 2D seismic lines acquired before and after the Tohoku earthquake in 2011 to illustrate this. A major challenge when using repeated 2D seismic for subsurface monitoring purposes is the lack of 3D calibration points and significantly less amount of data. For marine seismic acquisition, feathering issues and crossline dip effects become more critical compared to 3D seismic acquisition. Furthermore, the uncertainties arising from a non-ideal 2D seismic acquisition are hard to assess, since the 3D subsurface geometry has not been mapped. One way to shed more light on this challenge is to use 3D time lapse seismic modeling testing various crossline dips or geometries. Other ways are to use alternative data sources, such as bathymetry, time lapse gravity or electromagnetic data. The end result for all time-lapse monitoring projects is an interpretation associated with uncertainties, and for the 2D case these uncertainties are often large. The purpose of this talk is to discuss how to reduces and control these

TWODEE-2/MOD3, 2-D Time-Dependent Fuel Elements Thermal Analysis after PWR LOCA

International Nuclear Information System (INIS)

Lauben, G. N.

2001-01-01

1 - Description of problem or function: WREM-TOODEE2 is a two- dimensional, time-dependent, fuel-element thermal analysis program. Its primary purpose is to evaluate fuel-element thermal response during post-LOCA refill and reflood in a pressurized water reactor (PWR). 2 - Method of solution: TOODEE2 calculations are carried out in a two-dimensional mesh region defined in slab or cylindrical geometry by orthogonal grid lines. Coordinates which form order pairs are labeled x-y in slab geometry, and those in cylindrical geometry are labeled r-z for the axisymmetric case and r-theta for the polar case. Conduction and radiation are the only heat transfer mechanisms assumed within the boundaries of the mesh region. Convective and boiling heat transfer mechanisms are assumed at the boundaries. The program numerically solves the two-dimensional, time-dependent, heat conduction equation within the mesh region. 3 - Restrictions on the complexity of the problem: WREM-TOODEE2 considers only axisymmetric geometry although the equations for slab and polar geometry are included in the program

Time-dependent amplitude analysis of semileptonically-tagged $D^0 \\to K_S^0 \\pi^+ \\pi^-$ decays at LHCb

CERN Document Server

INSPIRE-00392459

2013-01-01

The hadronic decay $D^0 \\to K_S^0 \\pi^+ \\pi^-$ provides access to the measurement of the mixing parameters of the neutral D-meson system and allows to test for CP violation. A measurement of the mixing parameters $x_D$ and $y_D$ as well as of the parameters $|q/p|$ and $\\phi=arg(q,p)$, which govern indirect CP violation, will be performed based on a time-dependent amplitude-model analysis of the full LHCb dataset of 2011 and 2012 corresponding to an integrated luminosity of 3/fb.

Nonenhanced magnetic resonance angiography (MRA) of the calf arteries at 3 Tesla: intraindividual comparison of 3D flow-dependent subtractive MRA and 2D flow-independent non-subtractive MRA.

Science.gov (United States)

Knobloch, Gesine; Lauff, Marie-Teres; Hirsch, Sebastian; Schwenke, Carsten; Hamm, Bernd; Wagner, Moritz

2016-12-01

To prospectively compare 3D flow-dependent subtractive MRA vs. 2D flow-independent non-subtractive MRA for assessment of the calf arteries at 3 Tesla. Forty-two patients with peripheral arterial occlusive disease underwent nonenhanced MRA of calf arteries at 3 Tesla with 3D flow-dependent subtractive MRA (fast spin echo sequence; 3D-FSE-MRA) and 2D flow-independent non-subtractive MRA (balanced steady-state-free-precession sequence; 2D-bSSFP-MRA). Moreover, all patients underwent contrast-enhanced MRA (CE-MRA) as standard-of-reference. Two readers performed a per-segment evaluation for image quality (4 = excellent to 0 = non-diagnostic) and severity of stenosis. Image quality scores of 2D-bSSFP-MRA were significantly higher compared to 3D-FSE-MRA (medians across readers: 4 vs. 3; p Tesla with significantly higher image quality and diagnostic accuracy compared to 3D flow-dependent subtractive MRA (3D-FSE-MRA). • 2D flow-independent non-subtractive MRA (2D-bSSFP-MRA) is a robust NE-MRA technique at 3T • 2D-bSSFP-MRA outperforms 3D flow-dependent subtractive MRA (3D-FSE-MRA) as NE-MRA of calf arteries • 2D-bSSFP-MRA is a promising alternative to CE-MRA for calf PAOD evaluation.

Observation of $D^0 - \\overline{D}^0$ oscillations

CERN Document Server

AUTHOR|(CDS)2075808; Abellan Beteta, C; Adametz, A; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves Jr, A A; Amato, S; Amhis, Y; Anderlini, L; Anderson, J; Andreassen, R; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Bachmann, S; Back, J J; Baesso, C; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bates, A; Bauer, Th; Bay, A; Beddow, J; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Benayoun, M; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M -O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blanks, C; Blouw, J; Blusk, S; Bobrov, A; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Büchler-Germann, A; Burducea, I; Bursche, A; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carranza-Mejia, H; Carson, L; Carvalho Akiba, K; Casse, G; Cattaneo, M; Cauet, Ch; Charles, M; Charpentier, Ph; Chen, P; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Corti, G; Couturier, B; Cowan, G A; Craik, D; Cunliffe, S; Currie, R; D'Ambrosio, C; David, P; David, P N Y; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Simone, P; Decamp, D; Deckenhoff, M; Degaudenzi, H; Del Buono, L; Deplano, C; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Dickens, J; Dijkstra, H; Diniz Batista, P; Dogaru, M; Domingo Bonal, F; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisenhardt, S; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Elsby, D; Falabella, A; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furcas, S; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garofoli, J; Garosi, P; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hampson, T; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Harrison, P F; Hartmann, T; He, J; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicks, E; Hill, D; Hoballah, M; Hombach, C; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Hussain, N; Hutchcroft, D; Hynds, D; Iakovenko, V; Ilten, P; Imong, J; Jacobsson, R; Jaeger, A; Jans, E; Jansen, F; Jaton, P; Jing, F; John, M; Johnson, D; Jones, C R; Jost, B; Kaballo, M; Kandybei, S; Karacson, M; Karbach, T M; Kenyon, I R; Kerzel, U; Ketel, T; Keune, A; Khanji, B; Kochebina, O; Komarov, V; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucharczyk, M; Kudryavtsev, V; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J -P; Lefèvre, R; Leflat, A; Lefrançois, J; Leroy, O; Lesiak, T; Li, Y; Li Gioi, L; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; von Loeben, J; Lopes, J H; Lopez Asamar, E; Lopez-March, N; Lu, H; Luisier, J; Luo, H; Mac Raighne, A; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Maino, M; Malde, S; Manca, G; Mancinelli, G; Mangiafave, N; Marconi, U; Märki, R; Marks, J; Martellotti, G; Martens, A; Martin, L; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Martins Tostes, D; Massafferri, A; Matev, R; Mathe, Z; Matteuzzi, C; Matveev, M; Maurice, E; Mazurov, A; McCarthy, J; McNulty, R; Meadows, B; Meissner, M; Merk, M; Milanes, D A; Minard, M -N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neufeld, N; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Nicol, M; Niess, V; Nikitin, N; Nikodem, T; Nisar, S; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Pal, B K; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perego, D L; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pessina, G; Petridis, K; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pietrzyk, B; Pilař, T; Pinci, D; Playfer, S; Plo Casasus, M; Polci, F; Polok, G; Poluektov, A; Polycarpo, E; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pugatch, V; Puig Navarro, A; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Redford, S; Reid, M M; dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Rives Molina, V; Roa Romero, D A; Robbe, P; Rodrigues, E; Rodriguez Perez, P; Rogers, G J; Roiser, S; Romanovsky, V; Romero Vidal, A; Rouvinet, J; Ruf, T; Ruiz, H; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salzmann, C; Sanmartin Sedes, B; Sannino, M; Santacesaria, R; Santamarina Rios, C; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Schaack, P; Schiller, M; Schindler, H; Schleich, S; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M -H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Skwarnicki, T; Smith, N A; Smith, E; Smith, M; Sobczak, K; Sokoloff, M D; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Swientek, S; Szczekowski, M; Szczypka, P; Szumlak, T; T'Jampens, S; Teklishyn, M; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tonelli, D; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tresch, M; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Urner, D; Uwer, U; Vagnoni, V; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vilasis-Cardona, X; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; Waldi, R; Wallace, R; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wicht, J; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wishahi, J; Witek, M; Witzeling, W; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, F; Xing, Z; Yang, Z; Young, R; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhong, L; Zvyagin, A

2013-01-01

We report a measurement of the time-dependent ratio of $D^0 \\to K^+\\pi^-$ to $D^0 \\to K^-\\pi^+$ decay rates in $D^{*+}$-tagged events using 1.0 fb$^{-1}$ of integrated luminosity recorded by the LHCb experiment. We measure the mixing parameters $x'^2=(-0.9 \\pm 1.3)$x$10^{-4}, y'=(7.2 \\pm 2.4)$x$10^{-3}$ and the ratio of doubly-Cabibbo-suppressed to Cabibbo-favored decay rates $R_D=(3.52 \\pm 0.15)$x$10^{-3}$, where the uncertainties include statistical and systematic sources. The result excludes the no-mixing hypothesis with a probability corresponding to 9.1 standard deviations and represents the first observation of $D^0-\\bar{D}^0$ oscillations from a single measurement.

Time-step selection considerations in the analysis of reactor transients with DIF3D-K

International Nuclear Information System (INIS)

Taiwo, T.A.; Khalil, H.S.; Cahalan, J.E.; Morris, E.E.

1993-01-01

The DIF3D-K code solves the three-dimensional, time-dependent multigroup neutron diffusion equations by using a nodal approach for spatial discretization and either the theta method or one of three space-time factorization approaches for temporal integration of the nodal equations. The three space-time factorization options (namely, improved quasistatic, adiabatic and conventional point kinetics) were implemented because of their potential efficiency advantage for the analysis of transients in which the flux shape changes more slowly than its amplitude. Here we describe the implementation of DIF3D-K as the neutronics module within the SAS-HWR accident analysis code. We also describe the neutronics-related time step selection algorithms and their influence on the accuracy and efficiency of the various solution options

A recipe for consistent 3D management of velocity data and time-depth conversion using Vel-IO 3D

Science.gov (United States)

Maesano, Francesco E.; D'Ambrogi, Chiara

2017-04-01

3D geological model production and related basin analyses need large and consistent seismic dataset and hopefully well logs to support correlation and calibration; the workflow and tools used to manage and integrate different type of data control the soundness of the final 3D model. Even though seismic interpretation is a basic early step in such workflow, the most critical step to obtain a comprehensive 3D model useful for further analyses is represented by the construction of an effective 3D velocity model and a well constrained time-depth conversion. We present a complex workflow that includes comprehensive management of large seismic dataset and velocity data, the construction of a 3D instantaneous multilayer-cake velocity model, the time-depth conversion of highly heterogeneous geological framework, including both depositional and structural complexities. The core of the workflow is the construction of the 3D velocity model using Vel-IO 3D tool (Maesano and D'Ambrogi, 2017; https://github.com/framae80/Vel-IO3D) that is composed by the following three scripts, written in Python 2.7.11 under ArcGIS ArcPy environment: i) the 3D instantaneous velocity model builder creates a preliminary 3D instantaneous velocity model using key horizons in time domain and velocity data obtained from the analysis of well and pseudo-well logs. The script applies spatial interpolation to the velocity parameters and calculates the value of depth of each point on each horizon bounding the layer-cake velocity model. ii) the velocity model optimizer improves the consistency of the velocity model by adding new velocity data indirectly derived from measured depths, thus reducing the geometrical uncertainties in the areas located far from the original velocity data. iii) the time-depth converter runs the time-depth conversion of any object located inside the 3D velocity model The Vel-IO 3D tool allows one to create 3D geological models consistent with the primary geological constraints (e

Flow-through 3D biofuel cell anode for NAD+-dependent enzymes

International Nuclear Information System (INIS)

Rincon, Rosalba A.; Lau, Carolin; Garcia, Kristen E.; Atanassov, Plamen

2011-01-01

NAD + -dependent enzymes require the presence of catalysts for cofactor regeneration in order to be employed in enzymatic biofuel cells. Poly-(methylene green) catalysts have proven to help the oxidation reaction of NADH allowing for the use of such enzymes in electrocatalytic oxidation reactions. In this paper we present the development of 3D anode based on NAD + -dependent malate dehydrogenase. The 3D material chosen was reticulated vitreous carbon (RVC) which was modified with poly-(MG) for NADH oxidation and it also accommodated the porous immobilization matrix for MDH consisting of MWCNTs embedded in chitosan; allowing for mass transport of the substrate to the electrode. Scanning electron microscopy was used in order to characterize the poly-(MG)-modified RVC, and electrochemical evaluation of the anode was performed.

PRIMAS: a real-time 3D motion-analysis system

Science.gov (United States)

Sabel, Jan C.; van Veenendaal, Hans L. J.; Furnee, E. Hans

1994-03-01

The paper describes a CCD TV-camera-based system for real-time multicamera 2D detection of retro-reflective targets and software for accurate and fast 3D reconstruction. Applications of this system can be found in the fields of sports, biomechanics, rehabilitation research, and various other areas of science and industry. The new feature of real-time 3D opens an even broader perspective of application areas; animations in virtual reality are an interesting example. After presenting an overview of the hardware and the camera calibration method, the paper focuses on the real-time algorithms used for matching of the images and subsequent 3D reconstruction of marker positions. When using a calibrated setup of two cameras, it is now possible to track at least ten markers at 100 Hz. Limitations in the performance are determined by the visibility of the markers, which could be improved by adding a third camera.

Time-step selection considerations in the analysis of reactor transients with DIF3D-K

International Nuclear Information System (INIS)

Taiwo, T.A.; Khalil, H.S.; Cahalan, J.E.; Morris, E.E.

1993-01-01

The DIF3D-K code solves the three-dimensional, time-dependent multigroup neutron diffusion equations by using a nodal approach for spatial discretization and either the theta method or one of three space-time factorization approaches for temporal integration of the nodal equations. The three space-time factorization options (namely, improved quasistatic, adiabatic, and conventional point kinetics) were implemented because of their potential efficiency advantage for the analysis of transients in which the flux shape changes more slowly than its amplitude. In this paper, we describe the implementation of DIF3D-K as the neutronics module within the SAS-HWR accident analysis code. We also describe the neuronic-related time-step selection algorithms and their influence on the accuracy and efficiency of the various solution options

Detection of anatomical changes in lung cancer patients with 2D time-integrated, 2D time-resolved and 3D time-integrated portal dosimetry: a simulation study

Science.gov (United States)

Wolfs, Cecile J. A.; Brás, Mariana G.; Schyns, Lotte E. J. R.; Nijsten, Sebastiaan M. J. J. G.; van Elmpt, Wouter; Scheib, Stefan G.; Baltes, Christof; Podesta, Mark; Verhaegen, Frank

2017-08-01

The aim of this work is to assess the performance of 2D time-integrated (2D-TI), 2D time-resolved (2D-TR) and 3D time-integrated (3D-TI) portal dosimetry in detecting dose discrepancies between the planned and (simulated) delivered dose caused by simulated changes in the anatomy of lung cancer patients. For six lung cancer patients, tumor shift, tumor regression and pleural effusion are simulated by modifying their CT images. Based on the modified CT images, time-integrated (TI) and time-resolved (TR) portal dose images (PDIs) are simulated and 3D-TI doses are calculated. The modified and original PDIs and 3D doses are compared by a gamma analysis with various gamma criteria. Furthermore, the difference in the D 95% (ΔD 95%) of the GTV is calculated and used as a gold standard. The correlation between the gamma fail rate and the ΔD 95% is investigated, as well the sensitivity and specificity of all combinations of portal dosimetry method, gamma criteria and gamma fail rate threshold. On the individual patient level, there is a correlation between the gamma fail rate and the ΔD 95%, which cannot be found at the group level. The sensitivity and specificity analysis showed that there is not one combination of portal dosimetry method, gamma criteria and gamma fail rate threshold that can detect all simulated anatomical changes. This work shows that it will be more beneficial to relate portal dosimetry and DVH analysis on the patient level, rather than trying to quantify a relationship for a group of patients. With regards to optimizing sensitivity and specificity, different combinations of portal dosimetry method, gamma criteria and gamma fail rate should be used to optimally detect certain types of anatomical changes.

Detection of anatomical changes in lung cancer patients with 2D time-integrated, 2D time-resolved and 3D time-integrated portal dosimetry: a simulation study.

Science.gov (United States)

Wolfs, Cecile J A; Brás, Mariana G; Schyns, Lotte E J R; Nijsten, Sebastiaan M J J G; van Elmpt, Wouter; Scheib, Stefan G; Baltes, Christof; Podesta, Mark; Verhaegen, Frank

2017-07-12

The aim of this work is to assess the performance of 2D time-integrated (2D-TI), 2D time-resolved (2D-TR) and 3D time-integrated (3D-TI) portal dosimetry in detecting dose discrepancies between the planned and (simulated) delivered dose caused by simulated changes in the anatomy of lung cancer patients. For six lung cancer patients, tumor shift, tumor regression and pleural effusion are simulated by modifying their CT images. Based on the modified CT images, time-integrated (TI) and time-resolved (TR) portal dose images (PDIs) are simulated and 3D-TI doses are calculated. The modified and original PDIs and 3D doses are compared by a gamma analysis with various gamma criteria. Furthermore, the difference in the D 95% (ΔD 95% ) of the GTV is calculated and used as a gold standard. The correlation between the gamma fail rate and the ΔD 95% is investigated, as well the sensitivity and specificity of all combinations of portal dosimetry method, gamma criteria and gamma fail rate threshold. On the individual patient level, there is a correlation between the gamma fail rate and the ΔD 95% , which cannot be found at the group level. The sensitivity and specificity analysis showed that there is not one combination of portal dosimetry method, gamma criteria and gamma fail rate threshold that can detect all simulated anatomical changes. This work shows that it will be more beneficial to relate portal dosimetry and DVH analysis on the patient level, rather than trying to quantify a relationship for a group of patients. With regards to optimizing sensitivity and specificity, different combinations of portal dosimetry method, gamma criteria and gamma fail rate should be used to optimally detect certain types of anatomical changes.

LHCb: Time-dependent amplitude analysis of semileptonically-tagged $D^0 \\to K^0_S \\pi^+ \\pi^-$ decays at LHCb

CERN Multimedia

Reichert, S

2013-01-01

The self-conjugate hadronic decay $D^0 \\to K^0_S \\pi^+ \\pi^-$ provides access to the measurement of the mixing parameters of the neutral $D$-meson system and allows to test for CP violation. A measurement of the mixing parameters $x_D$ and $y_D$ as well as of the parameters $|q/p|$ and $\\phi$, which govern indirect CP violation, will be performed based on a time-dependent amplitude-model analysis of the full LHCb dataset of 2011 and 2012 corresponding to an integrated luminosity of 3fb$^{-1}$.

3D printing-based minimally invasive cannulated screw treatment of unstable pelvic fracture.

Science.gov (United States)

Cai, Leyi; Zhang, Yingying; Chen, Chunhui; Lou, Yiting; Guo, Xiaoshan; Wang, Jianshun

2018-04-04

Open reduction and internal fixation of pelvic fractures could restore the stability of the pelvic ring, but there were several problems. Minimally invasive closed reduction cannulated screw treatment of pelvic fractures has lots advantages. However, how to insert the cannulated screw safely and effectively to achieve a reliable fixation were still hard for orthopedist. Our aim was to explore the significance of 3D printing technology as a new method for minimally invasive cannulated screw treatment of unstable pelvic fracture. One hundred thirty-seven patients with unstable pelvic fractures from 2014 to 2016 were retrospectively analyzed. Based on the usage of 3D printing technology for preoperative simulation surgery, they were assigned to 3D printing group (n = 65) and control group (n = 72), respectively. These two groups were assessed in terms of operative time, intraoperative fluoroscopy, postoperative reduction effect, fracture healing time, and follow-up function. The effect of 3D printing technology was evaluated through minimally invasive cannulated screw treatment. There was no significant difference in these two groups with respect to general conditions, such as age, gender, fracture type, time from injury to operation, injury cause, and combined injury. Length of surgery and average number of fluoroscopies were statistically different for 3D printing group and the control group (p 3D printing group, versus 22/72 cases (30.6%) scored as excellent and 36/72 cases (50%) as good for the control group. On the other hand, using the Majeed functional scoring criteria, there were 27/65 (41.5%) excellent and 26/65 (40%) good cases for the 3D printing group in comparison to 30/72 (41.7%) and 28/72 (38.9%) cases for the control group, respectively. This suggests no significant difference between these two groups about the function outcomes. Full reduction and proper fixation of the pelvic ring and reconstruction of anatomical morphology are of great

3D airborne EM modeling based on the spectral-element time-domain (SETD) method

Science.gov (United States)

Cao, X.; Yin, C.; Huang, X.; Liu, Y.; Zhang, B., Sr.; Cai, J.; Liu, L.

2017-12-01

In the field of 3D airborne electromagnetic (AEM) modeling, both finite-difference time-domain (FDTD) method and finite-element time-domain (FETD) method have limitations that FDTD method depends too much on the grids and time steps, while FETD requires large number of grids for complex structures. We propose a time-domain spectral-element (SETD) method based on GLL interpolation basis functions for spatial discretization and Backward Euler (BE) technique for time discretization. The spectral-element method is based on a weighted residual technique with polynomials as vector basis functions. It can contribute to an accurate result by increasing the order of polynomials and suppressing spurious solution. BE method is a stable tine discretization technique that has no limitation on time steps and can guarantee a higher accuracy during the iteration process. To minimize the non-zero number of sparse matrix and obtain a diagonal mass matrix, we apply the reduced order integral technique. A direct solver with its speed independent of the condition number is adopted for quickly solving the large-scale sparse linear equations system. To check the accuracy of our SETD algorithm, we compare our results with semi-analytical solutions for a three-layered earth model within the time lapse 10-6-10-2s for different physical meshes and SE orders. The results show that the relative errors for magnetic field B and magnetic induction are both around 3-5%. Further we calculate AEM responses for an AEM system over a 3D earth model in Figure 1. From numerical experiments for both 1D and 3D model, we draw the conclusions that: 1) SETD can deliver an accurate results for both dB/dt and B; 2) increasing SE order improves the modeling accuracy for early to middle time channels when the EM field diffuses fast so the high-order SE can model the detailed variation; 3) at very late time channels, increasing SE order has little improvement on modeling accuracy, but the time interval plays

Time-dependent AdS backgrounds from S-branes

Energy Technology Data Exchange (ETDEWEB)

Deger, Nihat Sadik, E-mail: sadik.deger@boun.edu.tr [Department of Mathematics, Bogazici University, Bebek, 34342, Istanbul (Turkey); Feza Gursey Center for Physics and Mathematics, Bogazici University, Kandilli, 34684, Istanbul (Turkey)

2016-11-10

We construct time and radial dependent solutions that describe p-branes in chargeless S-brane backgrounds. In particular, there are some new M5- and D3-branes among our solutions which have AdS limits and contain a cosmological singularity as well. We also find a time-dependent version of the dyonic membrane configuration in 11-dimensions by applying a Lunin–Maldacena deformation to our new M5-brane solution.

Novel methods for real-time 3D facial recognition

OpenAIRE

Rodrigues, Marcos; Robinson, Alan

2010-01-01

In this paper we discuss our approach to real-time 3D face recognition. We argue the need for real time operation in a realistic scenario and highlight the required pre- and post-processing operations for effective 3D facial recognition. We focus attention to some operations including face and eye detection, and fast post-processing operations such as hole filling, mesh smoothing and noise removal. We consider strategies for hole filling such as bilinear and polynomial interpolation and Lapla...

A 3D resistivity model derived from the transient electromagnetic data observed on the Araba fault, Jordan

Science.gov (United States)

Rödder, A.; Tezkan, B.

2013-01-01

72 inloop transient electromagnetic soundings were carried out on two 2 km long profiles perpendicular and two 1 km and two 500 m long profiles parallel to the strike direction of the Araba fault in Jordan which is the southern part of the Dead Sea transform fault indicating the boundary between the African and Arabian continental plates. The distance between the stations was on average 50 m. The late time apparent resistivities derived from the induced voltages show clear differences between the stations located at the eastern and at the western part of the Araba fault. The fault appears as a boundary between the resistive western (ca. 100 Ωm) and the conductive eastern part (ca. 10 Ωm) of the survey area. On profiles parallel to the strike late time apparent resistivities were almost constant as well in the time dependence as in lateral extension at different stations, indicating a 2D resistivity structure of the investigated area. After having been processed, the data were interpreted by conventional 1D Occam and Marquardt inversion. The study using 2D synthetic model data showed, however, that 1D inversions of stations close to the fault resulted in fictitious layers in the subsurface thus producing large interpretation errors. Therefore, the data were interpreted by a 2D forward resistivity modeling which was then extended to a 3D resistivity model. This 3D model explains satisfactorily the time dependences of the observed transients at nearly all stations.

2-D CFD time-dependent thermal-hydraulic simulations of CANDU-6 moderator flows

Energy Technology Data Exchange (ETDEWEB)

Mehdi Zadeh, Foad [Department of Engineering Physics/Polytechnique Montréal, Montréal, QC (Canada); Étienne, Stéphane [Department of Mechanical Engineering/Polytechnique Montréal, Montréal, QC (Canada); Teyssedou, Alberto, E-mail: alberto.teyssedou@polymtl.ca [Department of Engineering Physics/Polytechnique Montréal, Montréal, QC (Canada)

2016-12-01

Highlights: • 2-D time-dependent CFD simulations of CANDU-6 moderator flows are presented. • A thermal-hydraulic code using thermal physical fluid properties is used. • The numerical approach and convergence is validated against available data. • Flow configurations are correlated using Richardson’s number. • Frequency components indicate moderator flow oscillations vs. Richardson numbers. - Abstract: The distribution of the fluid temperature and mass density of the moderator flow in CANDU-6 nuclear power reactors may affect the reactivity coefficient. For this reason, any possible moderator flow configuration and consequently the corresponding temperature distributions must be studied. In particular, the variations of the reactivity may result in major safety issues. For instance, excessive temperature excursions in the vicinity of the calandria tubes nearby local flow stagnation zones, may bring about partial boiling. Moreover, steady-state simulations have shown that for operating condition, intense buoyancy forces may be dominant, which can trigger a thermal stratification. Therefore, the numerical study of the time-dependent flow transition to such a condition, is of fundamental safety concern. Within this framework, this paper presents detailed time-dependent numerical simulations of CANDU-6 moderator flow for a wide range of flow conditions. To get a better insight of the thermal-hydraulic phenomena, the simulations were performed by covering long physical-time periods using an open-source code (Code-Saturne V3) developed by Électricité de France. The results show not only a region where the flow is characterized by coherent structures of flow fluctuations but also the existence of two limit cases where fluid oscillations disappear almost completely.

Theoretical Time Dependent Thermal Neutron Spectra and Reaction Rates in H2O and D2O

International Nuclear Information System (INIS)

Purohit, S.N.

1966-04-01

The early theoretical and experimental time dependent neutron thermalization studies were limited to the study of the transient spectrum in the diffusion period. The recent experimental measurements of the time dependent thermal neutron spectra and reaction rates, for a number of moderators, have generated considerable interest in the study of the time dependent Boltzmann equation. In this paper we present detailed results for the time dependent spectra and the reaction rates for resonance detectors using several scattering models of H 2 O and D 2 O. This study has been undertaken in order to interpret the integral time dependent neutron thermalization experiments in liquid moderators which have been performed at the AB Atomenergi. The proton gas and the deuteron gas models are inadequate to explain the measured reaction rates in H 2 O and D 2 O. The bound models of Nelkin for H 2 O and of Butler for D 2 O give much better agreement with the experimental results than the gas models. Nevertheless, some disagreement between theoretical and experimental results still persists. This study also indicates that the bound model of Butler and the effective mass 3. 6 gas model of Brown and St. John give almost identical reaction rates. It is also surprising to note that the calculated reaction rate for Cd for the Butler model appears to be in better agreement with the experimental results of D 2 O than of the Nelkin model with H 2 O experiments. The present reaction rate studies are sensitive enough so as to distinguish between the gas model and the bound model of a moderator. However, to investigate the details of a scattering law (such as the effect of the hindered rotations in H 2 O and D 2 O and the weights of different dynamical modes) with the help of these studies would require further theoretical as well as experimental investigations. Theoretical results can be further improved by improving the source for thermal neutrons, the group structure and the scattering

Clinical value of real time 3D sonohysterography and 2D sonohysterography in comparison to hysteroscopy with subsequent histopathological examination in perimenopausal women with abnormal uterine bleeding.

Science.gov (United States)

Kowalczyk, Dariusz; Guzikowski, Wojciech; Więcek, Jacek; Sioma-Markowska, Urszula

2012-01-01

In many publications the transvaginal ultrasound is regarded as the first step to diagnose the cause of uterine bleeding in perimenopausal women. In order to improve the sensitivity and specificity of the conventional ultrasound physiological saline solution was administered to the uterine cavity and after expansion of its walls the interior uterine cavity was examined. And this procedure is called 2D sonohysterography (SIS 2D). By the ultrasound scanners which enable to get 3D real time image a spatial evaluation of the uterine cavity is possible. Clinical value of the real time 3D sonohysterography and 2D sonohysterography compared to hysteroscopy with histopathological examination in perimenopausal women. The study concerned a group of 97 perimenopausal women with abnormal uterine bleeding. In all of them after a standard transvaginal ultrasonography a catheter was inserted into the uterine cavity. After expansion of the uterine walls by administering about 10 ml of 0,9% saline solution the uterine cavity was examined by conventional sonohysterography. Then a 3D imaging mode was activated and the uterine interior was examined by real time 3D ultrasonography. The ultrasound results were verified by hysteroscopy, the endometrial lesions were removed and underwent a histopathological examination. In two cases the SIS examination was impossible because of uterine cervix atresion. In the rest of examined group the SIS 2D sensitivity and specificity came up to 72 and 96% respectively. In the group of SIS 3D the sensitivity and specificity reached 83 and 99% respectively. Adding SIS 3D, a minimally invasive method, to conventional sonohysterography improves the precision of diagnosis of endometrial pathology, allows to get three-dimensional image of the uterine cavity and enables examination of endometrial lesions. The diagnostic precision of this procedure is similar to the results achieved by hysteroscopy.

Identification of novel CYP2D7-2D6 hybrids: non-functional and functional variants

Directory of Open Access Journals (Sweden)

Andrea Gaedigk

2010-10-01

Full Text Available Polymorphic expression of CYP2D6 contributes to the wide range of activity observed for this clinically important drug metabolizing enzyme. In this report we describe novel CYP2D7/2D6 hybrid genes encoding non-functional and functional CYP2D6 protein and a CYP2D7 variant that mimics a CYP2D7/2D6 hybrid gene. Five kb long PCR products encompassing the novel genes were entirely sequenced. A quantitative assay probing in different gene regions was employed to determine CYP2D6 and 2D7 copy number variations and the relative position of the hybrid genes within the locus was assessed by long-range PCR. In addition to the previously known CYP2D6*13 and *66 hybrids, we describe three novel non-functional CYP2D7-2D6 hybrids with gene switching in exon 2 (CYP2D6*79, intron 2 (CYP2D6*80 and intron 5 (CYP2D6*67. A CYP2D7-specific T-ins in exon 1 causes a detrimental frame shift. One subject revealed a CYP2D7 conversion in the 5’-flanking region of a CYP2D6*35 allele, was otherwise unaffected (designated CYP2D6*35B. Finally, three DNAs revealed a CYP2D7 gene with a CYP2D6-like region downstream of exon 9 (designated CYP2D7[REP6]. Quantitative copy number determination, sequence analyses and long-range PCR mapping were in agreement and excluded the presence of additional gene units. Undetected hybrid genes may cause over-estimation of CYP2D6 activity (CYP2D6*1/*1 vs *1/hybrid, etc, but may also cause results that may interfere with the genotype determination. Detection of hybrid events, ‘single’ and tandem, will contribute to more accurate phenotype prediction from genotype data.

Monitoring tumor motion by real time 2D/3D registration during radiotherapy.

Science.gov (United States)

Gendrin, Christelle; Furtado, Hugo; Weber, Christoph; Bloch, Christoph; Figl, Michael; Pawiro, Supriyanto Ardjo; Bergmann, Helmar; Stock, Markus; Fichtinger, Gabor; Georg, Dietmar; Birkfellner, Wolfgang

2012-02-01

In this paper, we investigate the possibility to use X-ray based real time 2D/3D registration for non-invasive tumor motion monitoring during radiotherapy. The 2D/3D registration scheme is implemented using general purpose computation on graphics hardware (GPGPU) programming techniques and several algorithmic refinements in the registration process. Validation is conducted off-line using a phantom and five clinical patient data sets. The registration is performed on a region of interest (ROI) centered around the planned target volume (PTV). The phantom motion is measured with an rms error of 2.56 mm. For the patient data sets, a sinusoidal movement that clearly correlates to the breathing cycle is shown. Videos show a good match between X-ray and digitally reconstructed radiographs (DRR) displacement. Mean registration time is 0.5 s. We have demonstrated that real-time organ motion monitoring using image based markerless registration is feasible. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Single Machine Scheduling and Due Date Assignment with Past-Sequence-Dependent Setup Time and Position-Dependent Processing Time

Directory of Open Access Journals (Sweden)

Chuan-Li Zhao

2014-01-01

Full Text Available This paper considers single machine scheduling and due date assignment with setup time. The setup time is proportional to the length of the already processed jobs; that is, the setup time is past-sequence-dependent (p-s-d. It is assumed that a job's processing time depends on its position in a sequence. The objective functions include total earliness, the weighted number of tardy jobs, and the cost of due date assignment. We analyze these problems with two different due date assignment methods. We first consider the model with job-dependent position effects. For each case, by converting the problem to a series of assignment problems, we proved that the problems can be solved in On4 time. For the model with job-independent position effects, we proved that the problems can be solved in On3 time by providing a dynamic programming algorithm.

Extra dimensions: 3D and time in PDF documentation

International Nuclear Information System (INIS)

Graf, N A

2011-01-01

Experimental science is replete with multi-dimensional information which is often poorly represented by the two dimensions of presentation slides and print media. Past efforts to disseminate such information to a wider audience have failed for a number of reasons, including a lack of standards which are easy to implement and have broad support. Adobe's Portable Document Format (PDF) has in recent years become the de facto standard for secure, dependable electronic information exchange. It has done so by creating an open format, providing support for multiple platforms and being reliable and extensible. By providing support for the ECMA standard Universal 3D (U3D) file format in its free Adobe Reader software, Adobe has made it easy to distribute and interact with 3D content. By providing support for scripting and animation, temporal data can also be easily distributed to a wide, non-technical audience. We discuss how the field of radiation imaging could benefit from incorporating full 3D information about not only the detectors, but also the results of the experimental analyses, in its electronic publications. In this article, we present examples drawn from high-energy physics, mathematics and molecular biology which take advantage of this functionality. We demonstrate how 3D detector elements can be documented, using either CAD drawings or other sources such as GEANT visualizations as input.

Flow-through 3D biofuel cell anode for NAD{sup +}-dependent enzymes

Energy Technology Data Exchange (ETDEWEB)

Rincon, Rosalba A.; Lau, Carolin; Garcia, Kristen E. [Department of Chemical and Nuclear Engineering, Center for Emerging Energy Technologies, University of New Mexico, Albuquerque, NM 87131 (United States); Atanassov, Plamen, E-mail: plamen@unm.ed [Department of Chemical and Nuclear Engineering, Center for Emerging Energy Technologies, University of New Mexico, Albuquerque, NM 87131 (United States)

2011-02-01

NAD{sup +}-dependent enzymes require the presence of catalysts for cofactor regeneration in order to be employed in enzymatic biofuel cells. Poly-(methylene green) catalysts have proven to help the oxidation reaction of NADH allowing for the use of such enzymes in electrocatalytic oxidation reactions. In this paper we present the development of 3D anode based on NAD{sup +}-dependent malate dehydrogenase. The 3D material chosen was reticulated vitreous carbon (RVC) which was modified with poly-(MG) for NADH oxidation and it also accommodated the porous immobilization matrix for MDH consisting of MWCNTs embedded in chitosan; allowing for mass transport of the substrate to the electrode. Scanning electron microscopy was used in order to characterize the poly-(MG)-modified RVC, and electrochemical evaluation of the anode was performed.

Real-time viability and apoptosis kinetic detection method of 3D multicellular tumor spheroids using the Celigo Image Cytometer.

Science.gov (United States)

Kessel, Sarah; Cribbes, Scott; Bonasu, Surekha; Rice, William; Qiu, Jean; Chan, Leo Li-Ying

2017-09-01

The development of three-dimensional (3D) multicellular tumor spheroid models for cancer drug discovery research has increased in the recent years. The use of 3D tumor spheroid models may be more representative of the complex in vivo tumor microenvironments in comparison to two-dimensional (2D) assays. Currently, viability of 3D multicellular tumor spheroids has been commonly measured on standard plate-readers using metabolic reagents such as CellTiter-Glo® for end point analysis. Alternatively, high content image cytometers have been used to measure drug effects on spheroid size and viability. Previously, we have demonstrated a novel end point drug screening method for 3D multicellular tumor spheroids using the Celigo Image Cytometer. To better characterize the cancer drug effects, it is important to also measure the kinetic cytotoxic and apoptotic effects on 3D multicellular tumor spheroids. In this work, we demonstrate the use of PI and caspase 3/7 stains to measure viability and apoptosis for 3D multicellular tumor spheroids in real-time. The method was first validated by staining different types of tumor spheroids with PI and caspase 3/7 and monitoring the fluorescent intensities for 16 and 21 days. Next, PI-stained and nonstained control tumor spheroids were digested into single cell suspension to directly measure viability in a 2D assay to determine the potential toxicity of PI. Finally, extensive data analysis was performed on correlating the time-dependent PI and caspase 3/7 fluorescent intensities to the spheroid size and necrotic core formation to determine an optimal starting time point for cancer drug testing. The ability to measure real-time viability and apoptosis is highly important for developing a proper 3D model for screening tumor spheroids, which can allow researchers to determine time-dependent drug effects that usually are not captured by end point assays. This would improve the current tumor spheroid analysis method to potentially better

Handheld real-time volumetric 3-D gamma-ray imaging

Energy Technology Data Exchange (ETDEWEB)

Haefner, Andrew, E-mail: ahaefner@lbl.gov [Lawrence Berkeley National Lab – Applied Nuclear Physics, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Barnowski, Ross [Department of Nuclear Engineering, UC Berkeley, 4155 Etcheverry Hall, MC 1730, Berkeley, CA 94720 (United States); Luke, Paul; Amman, Mark [Lawrence Berkeley National Lab – Applied Nuclear Physics, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Vetter, Kai [Department of Nuclear Engineering, UC Berkeley, 4155 Etcheverry Hall, MC 1730, Berkeley, CA 94720 (United States); Lawrence Berkeley National Lab – Applied Nuclear Physics, 1 Cyclotron Road, Berkeley, CA 94720 (United States)

2017-06-11

This paper presents the concept of real-time fusion of gamma-ray imaging and visual scene data for a hand-held mobile Compton imaging system in 3-D. The ability to obtain and integrate both gamma-ray and scene data from a mobile platform enables improved capabilities in the localization and mapping of radioactive materials. This not only enhances the ability to localize these materials, but it also provides important contextual information of the scene which once acquired can be reviewed and further analyzed subsequently. To demonstrate these concepts, the high-efficiency multimode imager (HEMI) is used in a hand-portable implementation in combination with a Microsoft Kinect sensor. This sensor, in conjunction with open-source software, provides the ability to create a 3-D model of the scene and to track the position and orientation of HEMI in real-time. By combining the gamma-ray data and visual data, accurate 3-D maps of gamma-ray sources are produced in real-time. This approach is extended to map the location of radioactive materials within objects with unknown geometry.

LandSIM3D: modellazione in real time 3D di dati geografici

Directory of Open Access Journals (Sweden)

Lambo Srl Lambo Srl

2009-03-01

Full Text Available LandSIM3D: realtime 3D modelling of geographic data LandSIM3D allows to model in 3D an existing landscape in a few hours only and geo-referenced offering great landscape analysis and understanding tools. 3D projects can then be inserted into the existing landscape with ease and precision. The project alternatives and impact can then be visualized and studied into their immediate environmental. The complex evolution of the landscape in the future can also be simulated and the landscape model can be manipulated interactively and better shared with colleagues. For that reason, LandSIM3D is different from traditional 3D imagery solutions, normally reserved for computer graphics experts. For more information about LandSIM3D, go to www.landsim3d.com.

Integration of real-time 3D capture, reconstruction, and light-field display

Science.gov (United States)

Zhang, Zhaoxing; Geng, Zheng; Li, Tuotuo; Pei, Renjing; Liu, Yongchun; Zhang, Xiao

2015-03-01

Effective integration of 3D acquisition, reconstruction (modeling) and display technologies into a seamless systems provides augmented experience of visualizing and analyzing real objects and scenes with realistic 3D sensation. Applications can be found in medical imaging, gaming, virtual or augmented reality and hybrid simulations. Although 3D acquisition, reconstruction, and display technologies have gained significant momentum in recent years, there seems a lack of attention on synergistically combining these components into a "end-to-end" 3D visualization system. We designed, built and tested an integrated 3D visualization system that is able to capture in real-time 3D light-field images, perform 3D reconstruction to build 3D model of the objects, and display the 3D model on a large autostereoscopic screen. In this article, we will present our system architecture and component designs, hardware/software implementations, and experimental results. We will elaborate on our recent progress on sparse camera array light-field 3D acquisition, real-time dense 3D reconstruction, and autostereoscopic multi-view 3D display. A prototype is finally presented with test results to illustrate the effectiveness of our proposed integrated 3D visualization system.

Novel real-time 3D radiological mapping solution for ALARA maximization, D and D assessments and radiological management

Energy Technology Data Exchange (ETDEWEB)

Dubart, Philippe; Hautot, Felix [AREVA Group, 1 route de la Noue, Gif sur Yvette (France); Morichi, Massimo; Abou-Khalil, Roger [AREVA Group, Tour AREVA-1, place Jean Millier, Paris (France)

2015-07-01

Good management of dismantling and decontamination (D and D) operations and activities is requiring safety, time saving and perfect radiological knowledge of the contaminated environment as well as optimization for personnel dose and minimization of waste volume. In the same time, Fukushima accident has imposed a stretch to the nuclear measurement operational approach requiring in such emergency situation: fast deployment and intervention, quick analysis and fast scenario definition. AREVA, as return of experience from his activities carried out at Fukushima and D and D sites has developed a novel multi-sensor solution as part of his D and D research, approach and method, a system with real-time 3D photo-realistic spatial radiation distribution cartography of contaminated premises. The system may be hand-held or mounted on a mobile device (robot, drone, e.g). In this paper, we will present our current development based on a SLAM technology (Simultaneous Localization And Mapping) and integrated sensors and detectors allowing simultaneous topographic and radiological (dose rate and/or spectroscopy) data acquisitions. This enabling technology permits 3D gamma activity cartography in real-time. (authors)

Novel real-time 3D radiological mapping solution for ALARA maximization, D and D assessments and radiological management

International Nuclear Information System (INIS)

Dubart, Philippe; Hautot, Felix; Morichi, Massimo; Abou-Khalil, Roger

2015-01-01

Good management of dismantling and decontamination (D and D) operations and activities is requiring safety, time saving and perfect radiological knowledge of the contaminated environment as well as optimization for personnel dose and minimization of waste volume. In the same time, Fukushima accident has imposed a stretch to the nuclear measurement operational approach requiring in such emergency situation: fast deployment and intervention, quick analysis and fast scenario definition. AREVA, as return of experience from his activities carried out at Fukushima and D and D sites has developed a novel multi-sensor solution as part of his D and D research, approach and method, a system with real-time 3D photo-realistic spatial radiation distribution cartography of contaminated premises. The system may be hand-held or mounted on a mobile device (robot, drone, e.g). In this paper, we will present our current development based on a SLAM technology (Simultaneous Localization And Mapping) and integrated sensors and detectors allowing simultaneous topographic and radiological (dose rate and/or spectroscopy) data acquisitions. This enabling technology permits 3D gamma activity cartography in real-time. (authors)

Spin-dependent Peltier effect in 3D topological insulators

Science.gov (United States)

Sengupta, Parijat; Kubis, Tillmann; Povolotskyi, Michael; Klimeck, Gerhard

2013-03-01

The Peltier effect represents the heat carrying capacity of a certain material when current passes through it. When two materials with different Peltier coefficients are placed together, the Peltier effect causes heat to flow either towards or away from the interface between them. This work utilizes the spin-polarized property of 3D topological insulator (TI) surface states to describe the transport of heat through the spin-up and spin-down channels. It has been observed that the spin channels are able to carry heat independently of each other. Spin currents can therefore be employed to supply or extract heat from an interface between materials with spin-dependent Peltier coefficients. The device is composed of a thin film of Bi2Se3 sandwiched between two layers of Bi2Te3. The thin film of Bi2Se3serves both as a normal and topological insulator. It is a normal insulator when its surfaces overlap to produce a finite band-gap. Using an external gate, Bi2Se3 film can be again tuned in to a TI. Sufficiently thick Bi2Te3 always retain TI behavior. Spin-dependent Peltier coefficients are obtained and the spin Nernst effect in TIs is shown by controlling the temperature gradient to convert charge current to spin current.

Nonenhanced magnetic resonance angiography (MRA) of the calf arteries at 3 Tesla: intraindividual comparison of 3D flow-dependent subtractive MRA and 2D flow-independent non-subtractive MRA

Energy Technology Data Exchange (ETDEWEB)

Knobloch, Gesine; Lauff, Marie-Teres; Hirsch, Sebastian; Hamm, Bernd; Wagner, Moritz [Charite - Universitaetsmedizin Berlin, Department of Radiology, Berlin (Germany); Schwenke, Carsten [SCO:SSiS Statistical Consulting, Berlin (Germany)

2016-12-15

To prospectively compare 3D flow-dependent subtractive MRA vs. 2D flow-independent non-subtractive MRA for assessment of the calf arteries at 3 Tesla. Forty-two patients with peripheral arterial occlusive disease underwent nonenhanced MRA of calf arteries at 3 Tesla with 3D flow-dependent subtractive MRA (fast spin echo sequence; 3D-FSE-MRA) and 2D flow-independent non-subtractive MRA (balanced steady-state-free-precession sequence; 2D-bSSFP-MRA). Moreover, all patients underwent contrast-enhanced MRA (CE-MRA) as standard-of-reference. Two readers performed a per-segment evaluation for image quality (4 = excellent to 0 = non-diagnostic) and severity of stenosis. Image quality scores of 2D-bSSFP-MRA were significantly higher compared to 3D-FSE-MRA (medians across readers: 4 vs. 3; p < 0.0001) with lower rates of non-diagnostic vessel segments on 2D-bSSFP-MRA (reader 1: <1 % vs. 15 %; reader 2: 1 % vs. 29 %; p < 0.05). Diagnostic performance of 2D-bSSFP-MRA and 3D-FSE-MRA across readers showed sensitivities of 89 % (214/240) vs. 70 % (168/240), p = 0.0153; specificities: 91 % (840/926) vs. 63 % (585/926), p < 0.0001; and diagnostic accuracies of 90 % (1054/1166) vs. 65 % (753/1166), p < 0.0001. 2D flow-independent non-subtractive MRA (2D-bSSFP-MRA) is a robust nonenhanced MRA technique for assessment of the calf arteries at 3 Tesla with significantly higher image quality and diagnostic accuracy compared to 3D flow-dependent subtractive MRA (3D-FSE-MRA). (orig.)

Stochastic Landau equation with time-dependent drift

International Nuclear Information System (INIS)

Swift, J.B.; Hohenberg, P.C.; Ahlers, G.

1991-01-01

The stochastic differential equation τ 0 ∂ tA =ε(t)A-g 3 A 3 +bar f(t), where bar f(t) is Gaussian white noise, is studied for arbitrary time dependence of ε(t). In particular, cases are considered where ε(t) goes through the bifurcation of the deterministic system, which occurs at ε=0. In the limit of weak noise an approximate analytic expression generalizing earlier work of Suzuki [Phys. Lett. A 67, 339 (1978); Prog. Theor. Phys. (Kyoto) Suppl. 64, 402 (1978)] is obtained for the time-dependent distribution function P(A,t). The results compare favorably with a numerical simulation of the stochastic equation for the case of a linear ramp (both increasing and decreasing) and for a periodic time dependence of ε(t). The procedure can be generalized to an arbitrary deterministic part ∂ tA =D(A,t)+bar f(t), but the deterministic equation may then have to be solved numerically

Time Demand and Radiation Dose in 3D-Fluoroscopy-based Navigation-assisted 3D-Fluoroscopy-controlled Pedicle Screw Instrumentations.

Science.gov (United States)

Balling, Horst

2018-05-01

Prospective single-center cohort study to record additional time requirements and radiation dose in navigation-assisted O-arm-controlled pedicle screw (PS) instrumentations. The aim of this study was to evaluate amount of extra-time and radiation dose for navigation-assisted PS instrumentations of the thoracolumbosacral spine using O-arm 3D-real-time-navigation (O3DN) compared to non-navigated spinal procedures (NNSPs) with a single C-arm and postoperative computed tomography (CT) scan for controlling PS positions. 3D-navigation is reported to enhance PS insertion accuracy. But time-consuming navigational steps and considerable additional radiation doses seem to limit this modern technique's attraction. A detailed analysis of additional time demand and extra-radiation dose in 3D-navigated spine surgery is not provided in literature, yet. From February 2011 through July 2015, 306 consecutive posterior instrumentations were performed in vertebral levels T10-S1 using O3DN for PS insertion. The duration of procedure-specific navigational steps of the overall collective (I) and the last cohort of 50 consecutive O3DN-surgeries (II) was compared to the average duration of analogous surgical steps in 100 consecutive NNSP using a single C-arm. 3D-radiation dose (dose-length-product, DLP) of navigational and postinstrumentation O-arm scans in group I and II was compared to the average DLP of 100 diagnostic lumbar CT scans. The average presurgical time from patient positioning on the operating table to skin incision was 46.2 ± 10.1 minutes (O3DN, I) and 40.6 ± 9.8 minutes (O3DN, II) versus 30.6 ± 8.3 minutes (NNSP) (P demand of 13.0 minutes compared to NNSP, and with a total DLP below that of a diagnostic lumbar CT scan (P ≈ 0.81). 4.

GPU acceleration towards real-time image reconstruction in 3D tomographic diffractive microscopy

Science.gov (United States)

Bailleul, J.; Simon, B.; Debailleul, M.; Liu, H.; Haeberlé, O.

2012-06-01

Phase microscopy techniques regained interest in allowing for the observation of unprepared specimens with excellent temporal resolution. Tomographic diffractive microscopy is an extension of holographic microscopy which permits 3D observations with a finer resolution than incoherent light microscopes. Specimens are imaged by a series of 2D holograms: their accumulation progressively fills the range of frequencies of the specimen in Fourier space. A 3D inverse FFT eventually provides a spatial image of the specimen. Consequently, acquisition then reconstruction are mandatory to produce an image that could prelude real-time control of the observed specimen. The MIPS Laboratory has built a tomographic diffractive microscope with an unsurpassed 130nm resolution but a low imaging speed - no less than one minute. Afterwards, a high-end PC reconstructs the 3D image in 20 seconds. We now expect an interactive system providing preview images during the acquisition for monitoring purposes. We first present a prototype implementing this solution on CPU: acquisition and reconstruction are tied in a producer-consumer scheme, sharing common data into CPU memory. Then we present a prototype dispatching some reconstruction tasks to GPU in order to take advantage of SIMDparallelization for FFT and higher bandwidth for filtering operations. The CPU scheme takes 6 seconds for a 3D image update while the GPU scheme can go down to 2 or > 1 seconds depending on the GPU class. This opens opportunities for 4D imaging of living organisms or crystallization processes. We also consider the relevance of GPU for 3D image interaction in our specific conditions.

A Scalable, Reconfigurable, and Dependable Time-Triggered Architecture

Science.gov (United States)

2003-07-01

apart from fundamentally event-triggered buses such as Byte- flight, CAN, Ethernet, LonWorks, or Profibus . The time-triggered and event-triggered...as CAN, Lon- Works, or Profibus use various priority, preassigned slot, or token schemes to resolve contention deterministically. In CAN, for example...B?«A9;¡ DP ö´A7ÄIq7©¶<D°»¤S7:q9;<J«J9¯¡¶©=BUIKTJIX9;>+BQIKGJIK©q72£59¯IO:q7¤A:=7Iq72>h©q7&«¥ª[G`_ahPME񓢱 /b]W -D^­9¯I «J72>A<?©q7

Effect of 24,25-dihydroxyvitamin D3 on 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] metabolism in vitamin D-deficient rats infused with 1,25-(OH)2D3

International Nuclear Information System (INIS)

Yamato, H.; Matsumoto, T.; Fukumoto, S.; Ikeda, K.; Ishizuka, S.; Ogata, E.

1989-01-01

Previous studies revealed that administration of 24,25-dihydroxyvitamin D3 [24,25-(OH)2D3] to calcium (Ca)-deficient rats causes a dose-dependent reduction in markedly elevated serum 1,25-(OH)2D3 level. Although the results suggested that the metabolism of 1,25-(OH)2D3 was accelerated by 24,25-(OH)2D3, those experiments could not define whether the enhanced metabolism of 1,25-(OH)2D3 played a role in the reduction in the serum 1,25-(OH)2D3 level. In the present study, in order to address this issue more specifically, serum 1,25-(OH)2D3 was maintained solely by exogenous administration through miniosmotic pumps of 1,25-(OH)2D3 into vitamin D-deficient rats. Thus, by measuring the serum 1,25-(OH)2D3 concentration, the effect of 24,25-(OH)2D3 on the MCR of 1,25-(OH)2D3 could be examined. Administration of 24,25-(OH)2D3 caused a dose-dependent enhancement in the MCR of 1,25-(OH)2D3, and 1 microgram/100 g rat.day 24,25-(OH)2D3, which elevated serum 24,25-(OH)2D3 to 8.6 +/- 1.3 ng/ml, significantly increased MCR and suppressed serum levels of 1,25-(OH)2D3. The effect of 24,25-(OH)2D3 on 1,25-(OH)2D3 metabolism developed with a rapid time course, and the recovery of iv injected [1 beta-3H]1,25-(OH)2D3 in blood was significantly reduced within 1 h. In addition, there was an increase in radioactivity in the water-soluble fraction of serum as well as in urine, suggesting that 1,25-(OH)2D3 is rapidly degraded to a water-soluble metabolite(s). Furthermore, the reduction in serum 1,25-(OH)2D3 was associated with a reduction in both serum and urinary Ca levels. Because the conversion of [3H]24,25-(OH)2D3 to [3H]1,24,25-(OH)2D3 or other metabolites was minimal in these rats, 24,25-(OH)2D3 appears to act without being converted into other metabolites. These results demonstrate that 24,25-(OH)2D3 rapidly stimulates the metabolism of 1,25-(OH)2D3 and reduces its serum level

Pharmacokinetics of 1,25(OH)(2)D(3) and 1alpha(OH)D(3) in normal and uraemic men

DEFF Research Database (Denmark)

Brandi, Lisbet; Egfjord, Martin; Olgaard, Klaus

2002-01-01

,25(OH)(2)D(3) (n=6) protocol. RESULTS: After oral administration of 1,25(OH)(2)D(3) the bioavailability of 1,25(OH)(2)D(3) was 70.6+/-5.8/72.2+/-4.8% in healthy volunteers/uraemic patients (n.s.). After i.v. administration the volume of distribution of 1,25(OH)(2)D(3) was similar, 0.49+/-0.14 vs 0...

48 CFR 852.271-72 - Time spent by counselee in counseling process.

Science.gov (United States)

2010-10-01

... counseling process. 852.271-72 Section 852.271-72 Federal Acquisition Regulations System DEPARTMENT OF... Clauses 852.271-72 Time spent by counselee in counseling process. As prescribed in 871.212, insert the following clause: Time Spent by Counselee in Counseling Process (APR 1984) The contractor agrees that no...

Towards real-time 3D ultrasound planning and personalized 3D printing for breast HDR brachytherapy treatment

International Nuclear Information System (INIS)

Poulin, Eric; Gardi, Lori; Fenster, Aaron; Pouliot, Jean; Beaulieu, Luc

2015-01-01

Two different end-to-end procedures were tested for real-time planning in breast HDR brachytherapy treatment. Both methods are using a 3D ultrasound (3DUS) system and a freehand catheter optimization algorithm. They were found fast and efficient. We demonstrated a proof-of-concept approach for personalized real-time guidance and planning to breast HDR brachytherapy treatments

3T MRI of the knee with optimised isotropic 3D sequences. Accurate delineation of intra-articular pathology without prolonged acquisition times

Energy Technology Data Exchange (ETDEWEB)

Abdulaal, Osamah M.; Rainford, Louise; Galligan, Marie; McGee, Allison [University College Dublin, Radiography and Diagnostic Imaging, School of Medicine, Belfield, Dublin (Ireland); MacMahon, Peter; Kavanagh, Eoin [Mater Misericordiae University Hospital, Department of Radiology, Dublin (Ireland); University College Dublin, School of Medicine, Dublin (Ireland); Cashman, James [Mater Misericordiae University Hospital, Department of Orthopaedics, Dublin (Ireland); University College Dublin, School of Medicine, Dublin (Ireland)

2017-11-15

To investigate optimised isotropic 3D turbo spin echo (TSE) and gradient echo (GRE)-based pulse sequences for visualisation of articular cartilage lesions within the knee joint. Optimisation of experimental imaging sequences was completed using healthy volunteers (n=16) with a 3-Tesla (3T) MRI scanner. Imaging of patients with knee cartilage abnormalities (n=57) was then performed. Acquired sequences included 3D proton density-weighted (PDW) TSE (SPACE) with and without fat-suppression (FS), and T2*W GRE (TrueFISP) sequences, with acquisition times of 6:51, 6:32 and 5:35 min, respectively. One hundred sixty-one confirmed cartilage lesions were detected and categorised (Grade II n=90, Grade III n=71). The highest sensitivity and specificity for detecting cartilage lesions were obtained with TrueFISP with values of 84.7% and 92%, respectively. Cartilage SNR mean for PDW SPACE-FS was the highest at 72.2. TrueFISP attained the highest CNR means for joint fluid/cartilage (101.5) and joint fluid/ligament (156.5), and the lowest CNR for cartilage/meniscus (48.5). Significant differences were identified across the three sequences for all anatomical structures with respect to SNR and CNR findings (p-value <0.05). Isotropic TrueFISP at 3T, optimised for acquisition time, accurately detects cartilage defects, although it demonstrated the lowest contrast between cartilage and meniscus. (orig.)

A multi-frequency electrical impedance tomography system for real-time 2D and 3D imaging

Science.gov (United States)

Yang, Yunjie; Jia, Jiabin

2017-08-01

This paper presents the design and evaluation of a configurable, fast multi-frequency Electrical Impedance Tomography (mfEIT) system for real-time 2D and 3D imaging, particularly for biomedical imaging. The system integrates 32 electrode interfaces and the current frequency ranges from 10 kHz to 1 MHz. The system incorporates the following novel features. First, a fully adjustable multi-frequency current source with current monitoring function is designed. Second, a flexible switching scheme is developed for arbitrary sensing configuration and a semi-parallel data acquisition architecture is implemented for high-frame-rate data acquisition. Furthermore, multi-frequency digital quadrature demodulation is accomplished in a high-capacity Field Programmable Gate Array. At last, a 3D imaging software, visual tomography, is developed for real-time 2D and 3D image reconstruction, data analysis, and visualization. The mfEIT system is systematically tested and evaluated from the aspects of signal to noise ratio (SNR), frame rate, and 2D and 3D multi-frequency phantom imaging. The highest SNR is 82.82 dB on a 16-electrode sensor. The frame rate is up to 546 fps at serial mode and 1014 fps at semi-parallel mode. The evaluation results indicate that the presented mfEIT system is a powerful tool for real-time 2D and 3D imaging.

Characterizing 3D sensors using the 3D modulation transfer function

Science.gov (United States)

Kellner, Timo; Breitbarth, Andreas; Zhang, Chen; Notni, Gunther

2018-03-01

The fields of optical 3D measurement system applications are continuously expanding and becoming more and more diverse. To evaluate appropriate systems for various measurement tasks, comparable parameters are necessary, whereas the 3D modulation transfer function (3D-MTF) has been established as a further criterion. Its aim is the determination of the system response between the measurement of a straight, sharp-edged cube and its opposite ideal calculated one. Within the scope of this work simulations and practical investigations regarding the 3D-MTF’s influences and its main issues are specifically investigated. Therefore, different determined edge radii representing the high-frequency spectra lead to various decreasing 3D-MTF characteristics. Furthermore, rising sampling frequencies improve its maximum transfer value to a saturation point in dependence of the radius. To approve these results of previous simulations, three fringe projection scanners were selected to determine the diversity. As the best 3D-MTF characteristic, a saturated transfer value of H_3D( f_N, 3D) = 0.79 has been identified at a sufficient sampling frequency, which is reached at four times the Nyquist limit. This high 3D resolution can mainly be achieved due to an improved camera projector interaction. Additionally, too small sampling ratios lead to uncertainties in the edge function determination, while higher ratios do not show major improvements. In conclusion, the 3D-MTF algorithm has thus been practically verified and its repeatability as well as its robustness have been confirmed.

Real-Time 3D Profile Measurement Using Structured Light

International Nuclear Information System (INIS)

Xu, L; Zhang, Z J; Ma, H; Yu, Y J

2006-01-01

The paper builds a real-time system of 3D profile measurement using structured-light imaging. It allows a hand-held object to rotate free in the space-time coded light field, which is projected by the projector. The surface of measured objects with projected coded light is imaged; the system shows surface reconstruction results of objects online. This feedback helps user to adjust object's pose in the light field according to the dismissed or error data, which would achieve the integrality of data used in reconstruction. This method can acquire denser data cloud and have higher reconstruction accuracy and efficiency. According to the real-time requirements, the paper presents the non-restricted light plane modelling which suits stripe structured light system, designs the three-frame stripes space-time coded pattern, and uses the advance ICP algorithms to acquire 3D data alignment from multiple view

Real-time Stereoscopic 3D for E-Robotics Learning

Directory of Open Access Journals (Sweden)

Richard Y. Chiou

2011-02-01

Full Text Available Following the design and testing of a successful 3-Dimensional surveillance system, this 3D scheme has been implemented into online robotics learning at Drexel University. A real-time application, utilizing robot controllers, programmable logic controllers and sensors, has been developed in the “MET 205 Robotics and Mechatronics” class to provide the students with a better robotic education. The integration of the 3D system allows the students to precisely program the robot and execute functions remotely. Upon the students’ recommendation, polarization has been chosen to be the main platform behind the 3D robotic system. Stereoscopic calculations are carried out for calibration purposes to display the images with the highest possible comfort-level and 3D effect. The calculations are further validated by comparing the results with students’ evaluations. Due to the Internet-based feature, multiple clients have the opportunity to perform the online automation development. In the future, students, in different universities, will be able to cross-control robotic components of different types around the world. With the development of this 3D ERobotics interface, automation resources and robotic learning can be shared and enriched regardless of location.

MODICO, 1-D Time-Dependent 1 Group, 2 Group Neutron Diffusion with Delayed Neutron Precursors

International Nuclear Information System (INIS)

Camiciola, P.; Cundari, D.; Montagnini, B.

1992-01-01

1 - Description of program or function: The program solves the 1-D time-dependent one and two group coarse-mesh neutron diffusion equations, coupled with the equations for the delayed-neutron precursor, in plane geometry. 2 - Method of solution: The program is based on a simple coarse-mesh cubic approximation formula for the spatial behaviour of the flux inside each interval. An implicit scheme (the time-integrated method) is used for the advancement of the solution. The resulting (block three-diagonal) matrix is inverted at each time step by Thomas' method. 3 - Restrictions on the complexity of the problem: Number of coarse- mesh intervals LE 80; number of material regions LE 10; number of delayed-neutron precursor groups LE 10. Typical mesh sizes range from 5 cm to 20 cm; typical step length (non-prompt critical transients) ranges from 0.005 to 0.1 seconds

Real-time 3-D space numerical shake prediction for earthquake early warning

Science.gov (United States)

Wang, Tianyun; Jin, Xing; Huang, Yandan; Wei, Yongxiang

2017-12-01

In earthquake early warning systems, real-time shake prediction through wave propagation simulation is a promising approach. Compared with traditional methods, it does not suffer from the inaccurate estimation of source parameters. For computation efficiency, wave direction is assumed to propagate on the 2-D surface of the earth in these methods. In fact, since the seismic wave propagates in the 3-D sphere of the earth, the 2-D space modeling of wave direction results in inaccurate wave estimation. In this paper, we propose a 3-D space numerical shake prediction method, which simulates the wave propagation in 3-D space using radiative transfer theory, and incorporate data assimilation technique to estimate the distribution of wave energy. 2011 Tohoku earthquake is studied as an example to show the validity of the proposed model. 2-D space model and 3-D space model are compared in this article, and the prediction results show that numerical shake prediction based on 3-D space model can estimate the real-time ground motion precisely, and overprediction is alleviated when using 3-D space model.

Temperature Dependent Rate Coefficients for the Gas-Phase Reaction of the OH Radical with Linear (L2, L3) and Cyclic (D3, D4) Permethylsiloxanes.

Science.gov (United States)

Bernard, François; Papanastasiou, Dimitrios K; Papadimitriou, Vassileios C; Burkholder, James B

2018-04-19

Permethylsiloxanes are emitted into the atmosphere during production and use as personal care products, lubricants, and cleaning agents. The predominate atmospheric loss process for permethylsiloxanes is expected to be via gas-phase reaction with the OH radical. In this study, rate coefficients, k(T), for the OH radical gas-phase reaction with the two simplest linear and cyclic permethylsiloxanes were measured using a pulsed laser photolysis-laser induced fluorescence technique over the temperature range of 240-370 K and a relative rate method at 294 K: hexamethyldisiloxane ((CH 3 ) 3 SiOSi(CH 3 ) 3 , L 2 ), k 1 ; octamethyltrisiloxane ([(CH 3 ) 3 SiO] 2 Si(CH 3 ) 2 , L 3 ), k 2 ; hexamethylcyclotrisiloxane ([-Si(CH 3 ) 2 O-] 3 , D 3 ), k 3 ; and octamethylcyclotetrasiloxane ([-Si(CH 3 ) 2 O-] 4 , D 4 ), k 4 . The obtained k(294 K) values and temperature-dependence expressions for the 240-370 K temperature range are (cm 3 molecule -1 s -1 , 2σ absolute uncertainties): k 1 (294 K) = (1.28 ± 0.08) × 10 -12 , k 1 ( T) = (1.87 ± 0.18) × 10 -11 exp(-(791 ± 27)/ T); k 2 (294 K) = (1.72 ± 0.10) × 10 -12 , k 2 ( T) = 1.96 × 10 -13 (T/298) 4.34 exp(657/ T); k 3 (294 K) = (0.82 ± 0.05) × 10 -12 , k 3 ( T) = (1.29 ± 0.19) × 10 -11 exp(-(805 ± 43)/ T); and k 4 (294 K) = (1.12 ± 0.10) × 10 -12 , k 4 ( T) = (1.80 ± 0.26) × 10 -11 exp(-(816 ± 43)/ T). The cyclic molecules were found to be less reactive than the analogous linear molecule with the same number of -CH 3 groups, while the linear and cyclic permethylsiloxane reactivity both increase with the increasing number of CH 3 - groups. The present results are compared with previous rate coefficient determinations where available. The permethylsiloxanes included in this study are atmospherically short-lived compounds with estimated atmospheric lifetimes of 11, 8, 17, and 13 days, respectively.

3-D time-dependent numerical model of flow patterns within a large-scale Czochralski system

Science.gov (United States)

Nam, Phil-Ouk; O, Sang-Kun; Yi, Kyung-Woo

2008-04-01

Silicon single crystals grown through the Czochralski (Cz) method have increased in size to 300 mm, resulting in the use of larger crucibles. The objective of this study is to investigate the continuous Cz method in a large crucible (800 mm), which is performed by inserting a polycrystalline silicon rod into the melt. The numerical model is based on a time-dependent and three-dimensional standard k- ɛ turbulent model using the analytical software package CFD-ACE+, version 2007. Wood's metal melt, which has a low melting point ( Tm=70 °C), was used as the modeling fluid. Crystal rotation given in the clockwise direction with rotation rates varying from 0 to 15 rpm, while the crucible was rotated counter-clockwise, with rotation rates between 0 and 3 rpm. The results show that asymmetrical phenomena of fluid flow arise as results of crystal and crucible rotation, and that these phenomena move with the passage of time. Near the crystal, the flow moves towards the crucible at the pole of the asymmetrical phenomena. Away from the poles, a vortex begins to form, which is strongly pronounced in the region between the poles.

TART 2000: A Coupled Neutron-Photon, 3-D, Combinatorial Geometry, Time Dependent, Monte Carlo Transport Code

International Nuclear Information System (INIS)

Cullen, D.E

2000-01-01

TART2000 is a coupled neutron-photon, 3 Dimensional, combinatorial geometry, time dependent Monte Carlo radiation transport code. This code can run on any modern computer. It is a complete system to assist you with input Preparation, running Monte Carlo calculations, and analysis of output results. TART2000 is also incredibly FAST; if you have used similar codes, you will be amazed at how fast this code is compared to other similar codes. Use of the entire system can save you a great deal of time and energy. TART2000 is distributed on CD. This CD contains on-line documentation for all codes included in the system, the codes configured to run on a variety of computers, and many example problems that you can use to familiarize yourself with the system. TART2000 completely supersedes all older versions of TART, and it is strongly recommended that users only use the most recent version of TART2000 and its data files

TART 2000 A Coupled Neutron-Photon, 3-D, Combinatorial Geometry, Time Dependent, Monte Carlo Transport Code

CERN Document Server

Cullen, D

2000-01-01

TART2000 is a coupled neutron-photon, 3 Dimensional, combinatorial geometry, time dependent Monte Carlo radiation transport code. This code can run on any modern computer. It is a complete system to assist you with input Preparation, running Monte Carlo calculations, and analysis of output results. TART2000 is also incredibly FAST; if you have used similar codes, you will be amazed at how fast this code is compared to other similar codes. Use of the entire system can save you a great deal of time and energy. TART2000 is distributed on CD. This CD contains on-line documentation for all codes included in the system, the codes configured to run on a variety of computers, and many example problems that you can use to familiarize yourself with the system. TART2000 completely supersedes all older versions of TART, and it is strongly recommended that users only use the most recent version of TART2000 and its data files.

Charge-dependent and A-dependent effects in isotope shifts of Coulomb displacement energies

International Nuclear Information System (INIS)

Sherr, R.

1977-01-01

Coulomb displacement energies in a series of isotopes generally decrease with A. This decrease can arise from an increase with A of the average distance of interaction between pairs of protons. In the shell model a decrease can also result from charge-independence-breaking effects if the neutron-proton interaction for the valence nucleons is more attractive than the neutron-neutron interaction. Using the model recently proposed by Sherr and Talmi for the 1d/sub 3/2/ shell, existing data for this shell and also the 1d/sub 5/2/ and 1f/sub 7/2/ shells were analyzed allowing all matrix elements to vary as A/sup -lambda/3/. Least squares calculations of the rms deviation sigma were carried out for varying values of lambda from -2 to +2. It was found that although there was a minimum in sigma vs lambda it was too shallow to exclude any lambda for -1 to +1 in the 1d/sub 3/2/ and 1f/sub 7/2/ shells or 0 to +1 in the 1d/sub 5/2/ shell. It is therefore not possible to distinguish between A dependence and charge dependence in this model. The magnitude of the latter as expressed in terms of (np-nn) matrix elements depends strongly on the former. As lambda increases from -1 to +1, these (np-nn) matrix elements decrease roughly linearly in absolute magnitude and eventually change sign. For lambda = 0 they have appreciable and reasonable magnitudes for the 1d/sub 3/2/ and 1f/sub 7/2/ shells but for the 1d/sub 5/2/ shell the values are too small to be considered significant

Detection of satellite cells during skeletal muscle wound healing in rats: time-dependent expressions of Pax7 and MyoD in relation to wound age.

Science.gov (United States)

Tian, Zhi-Ling; Jiang, Shu-Kun; Zhang, Miao; Wang, Meng; Li, Jiao-Yong; Zhao, Rui; Wang, Lin-Lin; Li, Shan-Shan; Liu, Min; Zhang, Meng-Zhou; Guan, Da-Wei

2016-01-01

The study was focused on time-dependent expressions of paired-box transcription factor 7 (Pax7) and myoblast determination protein (MyoD) during skeletal muscle wound healing. An animal model of skeletal muscle contusion was established in 40 Sprague-Dawley male rats. Samples were taken at 1, 3, 5, 7, 9, 13, 17, and 21 days after injury, respectively (five rats in each posttraumatic interval). Five rats were employed as control. By morphometric analysis, the data based on the number of Pax7(+)/MyoD(-), Pax7(+)/MyoD(+), and Pax7(-)/MyoD(+) cells were highly correlated with the wound age. Pax7 and MyoD expressions were upregulated after injury by Western blot and quantitative real-time PCR assays. The relative quantity of Pax7 protein peaked at 5 days after injury, which was >1.13, and decreased thereafter. Similarly, the relative quantity of MyoD mRNA expression peaked at 3 days after injury, which was >2.59. The relative quantity of Pax7 protein >0.73 or mRNA expression >2.38 or the relative quantity of MyoD protein >1.33 suggested a wound age of 3 to 7 days. The relative quantity of MyoD mRNA expression >2.02 suggested a wound age of 1 to 7 days post-injury. In conclusion, the expressions of Pax7 and MyoD are upregulated in a time-dependent manner during skeletal muscle wound healing, suggesting that Pax7 and MyoD may be potential markers for wound age estimation in skeletal muscle.

Time within time: 3D printed sculptures within holographic art practice

Science.gov (United States)

Chang, Yin-Ren; Richardson, Martin

2015-03-01

Holography is a time-based medium, which uses its own aesthetics and techniques to interpret colour and light. This exclusive descriptive language does not simply represent a particular scenario in the moment of recording, but also documents the performance light during the shooting process. Nowadays 3D graphic software and Internet offer practitioners greater mobility in both the development and the delivery of their artwork. Furthermore, the diverse web-based social media presents unlimited and various spaces to facilitate artists in the exchange of creative knowledge, it enables them to collaborate on their projects with external connections - audience, specialists, etc. Within the analogue holography art practice, there is a primary lack of interface, or, in other words, it cannot utilise any digital creative tools. 3D printing makes it possible to bridge the gap between cyber space and the holographic world; even more so, as this emerging technique also becomes a platform, which can connect computational data and light information. The application of 3D printing in contemporary art will reshape the process of creation, as well as the form of visual narrative itself. New technologies continually and increasingly involve the projection of another artistic dimension, and the term "visual" embarks on challenging the generally accepted notion of understanding art and interacting with it. As new pathways of practice are established, it will take years to build a complete understanding of this medium in order to be able to take a full advantage of the benefits its use offers. This paper is aimed at looking for the potential new ways of artistic expression, deriving from the interrelation between analogue holography and 3D printing. It will also attempt an articulate assessment of 3D printing within the dynamic holographic aesthetics.

A Measurement of the Time Dependence of B{sub d}-bar B{sub d} Mixing with Kaon Tagging

Energy Technology Data Exchange (ETDEWEB)

Wittlin, Jodi L.

2001-12-10

The time dependence of B{sub d} - {bar B}{sub d} mixing has been measured in b{bar b} events containing one or more kaons at the SLD experiment at the Stanford Linear Accelerator Center. A simultaneous measurement of the ''right sign production fraction'' of kaons from B{sub d} decays has also been made. The initial state B hadron flavor was determined using the large forward-backward asymmetry provided by the polarized electron beam of the SLC in combination with a jet charge technique and information from the opposite hemisphere. From a sample of 400,000 Z{sup 0} events collected by the SLD experiment at SLC from 1996 to 1998, the kaon right sign production fraction has been measured to be 0.797 {+-} 0.022 and the mass difference between the two B{sub d} eigenstates has been measured to be {Delta}m{sub d} = 0.503 {+-} 0.028 {+-} 0.020 ps{sup -1}.

The 3D model: explaining densification and deformation mechanisms by using 3D parameter plots.

Science.gov (United States)

Picker, Katharina M

2004-04-01

The aim of the study was to analyze very differently deforming materials using 3D parameter plots and consequently to gain deeper insights into the densification and deformation process described with the 3D model in order to define an ideal tableting excipient. The excipients used were dicalcium phosphate dihydrate (DCPD), sodium chloride (NaCl), microcrystalline cellulose (MCC), xylitol, mannitol, alpha-lactose monohydrate, maltose, hydroxypropyl methylcellulose (HPMC), sodium carboxymethylcellulose (NaCMC), cellulose acetate (CAC), maize starch, potato starch, pregelatinized starch, and maltodextrine. All of the materials were tableted to graded maximum relative densities (rhorel, max) using an eccentric tableting machine. The data which resulted, namely force, displacement, and time, were analyzed by the application of 3D modeling. Different particle size fractions of DCPD, CAC, and MCC were analyzed in addition. Brittle deforming materials such as DCPD exhibited a completely different 3D parameter plot, with low time plasticity, d, and low pressure plasticity, e, and a strong decrease in omega values when densification increased, in contrast to the plastically deforming MCC, which had much higher d, e, and omega values. e and omega values changed only slightly when densification increased for MCC. NaCl showed less of a decrease in omega values than DCPD did, and the d and e values were between those of MCC and DCPD. The sugar alcohols, xylitol and mannitol, behaved in a similar fashion to sodium chloride. This is also valid for the crystalline sugars, alpha-lactose monohydrate, and maltose. However, the sugars are more brittle than the sugar alcohols. The cellulose derivatives, HPMC, NaCMC, and CAC, are as plastic as MCC, however, their elasticity depends on substitution indicated by lower (more elastic) or higher (less elastic) omega values. The native starches, maize starch and potato starch, are very elastic, and pregelatinized starch and maltodextrine are

A Comparison of Iterative 2D-3D Pose Estimation Methods for Real-Time Applications

DEFF Research Database (Denmark)

Grest, Daniel; Krüger, Volker; Petersen, Thomas

2009-01-01

This work compares iterative 2D-3D Pose Estimation methods for use in real-time applications. The compared methods are available for public as C++ code. One method is part of the openCV library, namely POSIT. Because POSIT is not applicable for planar 3Dpoint congurations, we include the planar P...

Comparison Between 2D and 3D Simulations of Rate Dependent Friction Using DEM

Science.gov (United States)

Wang, C.; Elsworth, D.

2017-12-01

Rate-state dependent constitutive laws of frictional evolution have been successful in representing many of the first- and second- order components of earthquake rupture. Although this constitutive law has been successfully applied in numerical models, difficulty remains in efficient implementation of this constitutive law in computationally-expensive granular mechanics simulations using discrete element methods (DEM). This study introduces a novel approach in implementing a rate-dependent constitutive relation of contact friction into DEM. This is essentially an implementation of a slip-weakening constitutive law onto local particle contacts without sacrificing computational efficiency. This implementation allows the analysis of slip stability of simulated fault gouge materials. Velocity-stepping experiments are reported on both uniform and textured distributions of quartz and talc as 3D analogs of gouge mixtures. Distinct local slip stability parameters (a-b) are assigned to the quartz and talc, respectively. We separately vary talc content from 0 to 100% in the uniform mixtures and talc layer thickness from 1 to 20 particles in the textured mixtures. Applied shear displacements are cycled through velocities of 1μm/s and 10μm/s. Frictional evolution data are collected and compared to 2D simulation results. We show that dimensionality significantly impacts the evolution of friction. 3D simulation results are more representative of laboratory observed behavior and numerical noise is shown at a magnitude of 0.01 in terms of friction coefficient. Stability parameters (a-b) can be straightforwardly obtained from analyzing velocity steps, and are different from locally assigned (a-b) values. Sensitivity studies on normal stress, shear velocity, particle size, local (a-b) values, and characteristic slip distance (Dc) show that the implementation is sensitive to local (a-b) values and relations between (Dc) and particle size.

Application of the Real-Time Time-Dependent Density Functional Theory to Excited-State Dynamics of Molecules and 2D Materials

Science.gov (United States)

Miyamoto, Yoshiyuki; Rubio, Angel

2018-04-01

We review our recent developments in the ab initio simulation of excited-state dynamics within the framework of time-dependent density functional theory (TDDFT). Our targets range from molecules to 2D materials, although the methods are general and can be applied to any other finite and periodic systems. We discuss examples of excited-state dynamics obtained by real-time TDDFT coupled with molecular dynamics (MD) and the Ehrenfest approximation, including photoisomerization in molecules, photoenhancement of the weak interatomic attraction of noble gas atoms, photoenhancement of the weak interlayer interaction of 2D materials, pulse-laser-induced local bond breaking of adsorbed atoms on 2D sheets, modulation of UV light intensity by graphene nanoribbons at terahertz frequencies, and collision of high-speed ions with the 2D material to simulate the images taken by He ion microscopy. We illustrate how the real-time TDDFT approach is useful for predicting and understanding non-equilibrium dynamics in condensed matter. We also discuss recent developments that address the excited-state dynamics of systems out of equilibrium and future challenges in this fascinating field of research.

Measurements of branching fractions and time-dependent CP violating asymmetries in B0 → D*±D#-+# decays

International Nuclear Information System (INIS)

2012-01-01

We report measurements of branching fractions and time-dependent CP asymmetries in B 0 → D + D - and B 0 → D* ± D # -+# decays using a data sample that contains (772 ± 11) x 10 6 BB - pairs collected at the Υ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e + e - collider. We determine the branching fractions to be Β(B 0 → D + D - ) = (2.12 ± 0.16 ± 0.18) x 10 -4 and Β(B 0 → D* ± D # -+#) = (6.14 ± 0.29 ± 0.50) x 10 -4 . We measure CP asymmetry parameters S D# sup +# D# sup -# = -1.06 -0.14 +0.21 ± 0.08 and C D# sup +# D# sup -# = -0.43 ± 0.16 ± 0.05 in B 0 → D + D - and A D*D = +0.06 ± 0.05 ± 0.02, S D*D = -0.78 ± 0.15 ± 0.05, C D*D = -0.01 ± 0.11 ± 0.04, ΔS D*D = -0.13 ± 0.15 ± 0.04 and ΔC D*D = +0.12 ± 0.11 ± 0.03 in B 0 → D* ± D # -+#, where the first uncertainty is statistical and the second is systematic. We exclude the conservation of CP symmetry in both decays at equal to or greater than 4σ significance.

Interactive initialization of 2D/3D rigid registration

Energy Technology Data Exchange (ETDEWEB)

Gong, Ren Hui; Güler, Özgür [The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children' s National Medical Center, Washington, DC 20010 (United States); Kürklüoglu, Mustafa [Department of Cardiac Surgery, Children' s National Medical Center, Washington, DC 20010 (United States); Lovejoy, John [Department of Orthopaedic Surgery and Sports Medicine, Children' s National Medical Center, Washington, DC 20010 (United States); Yaniv, Ziv, E-mail: ZYaniv@childrensnational.org [The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children' s National Medical Center, Washington, DC 20010 and Departments of Pediatrics and Radiology, George Washington University, Washington, DC 20037 (United States)

2013-12-15

Purpose: Registration is one of the key technical components in an image-guided navigation system. A large number of 2D/3D registration algorithms have been previously proposed, but have not been able to transition into clinical practice. The authors identify the primary reason for the lack of adoption with the prerequisite for a sufficiently accurate initial transformation, mean target registration error of about 10 mm or less. In this paper, the authors present two interactive initialization approaches that provide the desired accuracy for x-ray/MR and x-ray/CT registration in the operating room setting. Methods: The authors have developed two interactive registration methods based on visual alignment of a preoperative image, MR, or CT to intraoperative x-rays. In the first approach, the operator uses a gesture based interface to align a volume rendering of the preoperative image to multiple x-rays. The second approach uses a tracked tool available as part of a navigation system. Preoperatively, a virtual replica of the tool is positioned next to the anatomical structures visible in the volumetric data. Intraoperatively, the physical tool is positioned in a similar manner and subsequently used to align a volume rendering to the x-ray images using an augmented reality (AR) approach. Both methods were assessed using three publicly available reference data sets for 2D/3D registration evaluation. Results: In the authors' experiments, the authors show that for x-ray/MR registration, the gesture based method resulted in a mean target registration error (mTRE) of 9.3 ± 5.0 mm with an average interaction time of 146.3 ± 73.0 s, and the AR-based method had mTREs of 7.2 ± 3.2 mm with interaction times of 44 ± 32 s. For x-ray/CT registration, the gesture based method resulted in a mTRE of 7.4 ± 5.0 mm with an average interaction time of 132.1 ± 66.4 s, and the AR-based method had mTREs of 8.3 ± 5.0 mm with interaction times of 58 ± 52 s. Conclusions: Based on

Interactive initialization of 2D/3D rigid registration

International Nuclear Information System (INIS)

Gong, Ren Hui; Güler, Özgür; Kürklüoglu, Mustafa; Lovejoy, John; Yaniv, Ziv

2013-01-01

Purpose: Registration is one of the key technical components in an image-guided navigation system. A large number of 2D/3D registration algorithms have been previously proposed, but have not been able to transition into clinical practice. The authors identify the primary reason for the lack of adoption with the prerequisite for a sufficiently accurate initial transformation, mean target registration error of about 10 mm or less. In this paper, the authors present two interactive initialization approaches that provide the desired accuracy for x-ray/MR and x-ray/CT registration in the operating room setting. Methods: The authors have developed two interactive registration methods based on visual alignment of a preoperative image, MR, or CT to intraoperative x-rays. In the first approach, the operator uses a gesture based interface to align a volume rendering of the preoperative image to multiple x-rays. The second approach uses a tracked tool available as part of a navigation system. Preoperatively, a virtual replica of the tool is positioned next to the anatomical structures visible in the volumetric data. Intraoperatively, the physical tool is positioned in a similar manner and subsequently used to align a volume rendering to the x-ray images using an augmented reality (AR) approach. Both methods were assessed using three publicly available reference data sets for 2D/3D registration evaluation. Results: In the authors' experiments, the authors show that for x-ray/MR registration, the gesture based method resulted in a mean target registration error (mTRE) of 9.3 ± 5.0 mm with an average interaction time of 146.3 ± 73.0 s, and the AR-based method had mTREs of 7.2 ± 3.2 mm with interaction times of 44 ± 32 s. For x-ray/CT registration, the gesture based method resulted in a mTRE of 7.4 ± 5.0 mm with an average interaction time of 132.1 ± 66.4 s, and the AR-based method had mTREs of 8.3 ± 5.0 mm with interaction times of 58 ± 52 s. Conclusions: Based on the

Theoretical Time Dependent Thermal Neutron Spectra and Reaction Rates in H{sub 2}O and D{sub 2}O

Energy Technology Data Exchange (ETDEWEB)

Purohit, S N

1966-04-15

The early theoretical and experimental time dependent neutron thermalization studies were limited to the study of the transient spectrum in the diffusion period. The recent experimental measurements of the time dependent thermal neutron spectra and reaction rates, for a number of moderators, have generated considerable interest in the study of the time dependent Boltzmann equation. In this paper we present detailed results for the time dependent spectra and the reaction rates for resonance detectors using several scattering models of H{sub 2}O and D{sub 2}O. This study has been undertaken in order to interpret the integral time dependent neutron thermalization experiments in liquid moderators which have been performed at the AB Atomenergi. The proton gas and the deuteron gas models are inadequate to explain the measured reaction rates in H{sub 2}O and D{sub 2}O. The bound models of Nelkin for H{sub 2}O and of Butler for D{sub 2}O give much better agreement with the experimental results than the gas models. Nevertheless, some disagreement between theoretical and experimental results still persists. This study also indicates that the bound model of Butler and the effective mass 3. 6 gas model of Brown and St. John give almost identical reaction rates. It is also surprising to note that the calculated reaction rate for Cd for the Butler model appears to be in better agreement with the experimental results of D{sub 2}O than of the Nelkin model with H{sub 2}O experiments. The present reaction rate studies are sensitive enough so as to distinguish between the gas model and the bound model of a moderator. However, to investigate the details of a scattering law (such as the effect of the hindered rotations in H{sub 2}O and D{sub 2}O and the weights of different dynamical modes) with the help of these studies would require further theoretical as well as experimental investigations. Theoretical results can be further improved by improving the source for thermal neutrons, the

Time-dependent EQPET analysis of TSC

International Nuclear Information System (INIS)

Takahashi, Akito

2006-01-01

Time-dependent fusion rates for 2D and 4D reactions are calculated for squeezing of tetrahedral symmetric condensate (TSC) from about 100 pm size to its minimum size (about 10 fm), within about 75 fs squeezing motion. Life time of the minimum TSC state is yet to be studied. Time-averaged fusion rates are given by assuming the life time of minimum TSC state is negligible. Time-averaged 2D fusion rate was given as 2.9x10 -25 f/s/pair, and time-averaged 4D fusion rate was 5.5x10 -8 f/s/cl. These values are compared with 1.0x10 -20 f/s/pair for 2D and 1.0x10 -9 f/s/cl for 4D, respectively, of previously estimated values by electronic quasi-particle expansion theory/TSC models. Effective fusion time by the TSC squeezing motion was estimated as 0.014 fs: namely fusions may happen in very short time interval. (author)

Multithreaded real-time 3D image processing software architecture and implementation

Science.gov (United States)

Ramachandra, Vikas; Atanassov, Kalin; Aleksic, Milivoje; Goma, Sergio R.

2011-03-01

Recently, 3D displays and videos have generated a lot of interest in the consumer electronics industry. To make 3D capture and playback popular and practical, a user friendly playback interface is desirable. Towards this end, we built a real time software 3D video player. The 3D video player displays user captured 3D videos, provides for various 3D specific image processing functions and ensures a pleasant viewing experience. Moreover, the player enables user interactivity by providing digital zoom and pan functionalities. This real time 3D player was implemented on the GPU using CUDA and OpenGL. The player provides user interactive 3D video playback. Stereo images are first read by the player from a fast drive and rectified. Further processing of the images determines the optimal convergence point in the 3D scene to reduce eye strain. The rationale for this convergence point selection takes into account scene depth and display geometry. The first step in this processing chain is identifying keypoints by detecting vertical edges within the left image. Regions surrounding reliable keypoints are then located on the right image through the use of block matching. The difference in the positions between the corresponding regions in the left and right images are then used to calculate disparity. The extrema of the disparity histogram gives the scene disparity range. The left and right images are shifted based upon the calculated range, in order to place the desired region of the 3D scene at convergence. All the above computations are performed on one CPU thread which calls CUDA functions. Image upsampling and shifting is performed in response to user zoom and pan. The player also consists of a CPU display thread, which uses OpenGL rendering (quad buffers). This also gathers user input for digital zoom and pan and sends them to the processing thread.

Real Time 3D Facial Movement Tracking Using a Monocular Camera

Directory of Open Access Journals (Sweden)

Yanchao Dong

2016-07-01

Full Text Available The paper proposes a robust framework for 3D facial movement tracking in real time using a monocular camera. It is designed to estimate the 3D face pose and local facial animation such as eyelid movement and mouth movement. The framework firstly utilizes the Discriminative Shape Regression method to locate the facial feature points on the 2D image and fuses the 2D data with a 3D face model using Extended Kalman Filter to yield 3D facial movement information. An alternating optimizing strategy is adopted to fit to different persons automatically. Experiments show that the proposed framework could track the 3D facial movement across various poses and illumination conditions. Given the real face scale the framework could track the eyelid with an error of 1 mm and mouth with an error of 2 mm. The tracking result is reliable for expression analysis or mental state inference.

Implementation of a Stress-dependent Strength Material Model in PLAXIS 3D

DEFF Research Database (Denmark)

Knudsen, Bjørn S.; Østergaard, Martin Underlin; Clausen, Johan

To perform tests on bucket foundations, full-scale testing is rarely used since it is rather expensive. Instead small-scale testing is done to examine the static and dynamic behaviour of such structures. In the laboratory at Aalborg University, small-scale testing of offshore support structures can...... be performed in a pressure tank, where a pressure can be applied in order to simulate deep water situations. Since the test set-up is downscaled 15 to 30 times compared to real-life structures, stresses and strains will be downscaled too. For soils, normally a Mohr-Coulomb failure criterion is used......, and in the region of small stresses, a non-linear behaviour is observed - unlike the linear behaviour normally assumed in Mohr-Coulomb. To better model this non-linearity, a stress-dependent model for the strength of the soil material is sought to be implemented in PLAXIS 3D through FORTRAN to improve...

3D Multi‐source Least‐squares Reverse Time Migration

KAUST Repository

Dai, Wei; Boonyasiriwat, Chaiwoot; Schuster, Gerard T.

2010-01-01

: random time shift, random source polarity and random source location selected from a pre‐designed table. Numerical tests for the 3D SEG/EAGE Overthrust model show that multi‐source LSRTM can suppress migration artifacts in the migration image and remove

Correction of a Depth-Dependent Lateral Distortion in 3D Super-Resolution Imaging.

Directory of Open Access Journals (Sweden)

Lina Carlini

Full Text Available Three-dimensional (3D localization-based super-resolution microscopy (SR requires correction of aberrations to accurately represent 3D structure. Here we show how a depth-dependent lateral shift in the apparent position of a fluorescent point source, which we term `wobble`, results in warped 3D SR images and provide a software tool to correct this distortion. This system-specific, lateral shift is typically > 80 nm across an axial range of ~ 1 μm. A theoretical analysis based on phase retrieval data from our microscope suggests that the wobble is caused by non-rotationally symmetric phase and amplitude aberrations in the microscope's pupil function. We then apply our correction to the bacterial cytoskeletal protein FtsZ in live bacteria and demonstrate that the corrected data more accurately represent the true shape of this vertically-oriented ring-like structure. We also include this correction method in a registration procedure for dual-color, 3D SR data and show that it improves target registration error (TRE at the axial limits over an imaging depth of 1 μm, yielding TRE values of < 20 nm. This work highlights the importance of correcting aberrations in 3D SR to achieve high fidelity between the measurements and the sample.

SANDYL, 3-D Time-Dependent and Space-Dependent Gamma Electron Cascade Transport by Monte-Carlo

International Nuclear Information System (INIS)

Haggmark, L.G.

1980-01-01

1 - Description of problem or function: SANDYL performs three- dimensional, time and space dependent Monte Carlo transport calculations for photon-electron cascades in complex systems. 2 - Method of solution: The problem geometry is divided into zones of homogeneous atomic composition bounded by sections of planes and quadrics. The material of each zone is a specified element or combination of elements. For a photon history, the trajectory is generated by following the photon from scattering to scattering using the various probability distributions to find distances between collisions, types of collisions, types of secondaries, and their energies and scattering angles. The photon interactions are photoelectric absorption (atomic ionization), coherent scattering, incoherent scattering, and pair production. The secondary photons which are followed include Bremsstrahlung, fluorescence photons, and positron-electron annihilation radiation. The condensed-history Monte Carlo method is used for the electron transport. In a history, the spatial steps taken by an electron are pre-computed and may include the effects of a number of collisions. The corresponding scattering angle and energy loss in the step are found from the multiple scattering distributions of these quantities. Atomic ionization and secondary particles are generated with the step according to the probabilities for their occurrence. Electron energy loss is through inelastic electron-electron collisions, Bremsstrahlung generation, and polarization of the medium (density effect). Included in the loss is the fluctuation due to the variation in the number of energy-loss collisions in a given Monte Carlo step (straggling). Scattering angular distributions are determined from elastic nuclear-collision cross sections corrected for electron-electron interactions. The secondary electrons which are followed included knock-on, pair, Auger (through atomic ionizations), Compton, and photoelectric electrons. 3

3D time-dependent flow computations using a molecular stress function model with constraint release

DEFF Research Database (Denmark)

Rasmussen, Henrik Koblitz

2002-01-01

The numerical simulation of time dependent viscoelastic flow (in three dimensions) is of interest in connection with a variety of polymer processing operations. The application of the numerical simulation techniques is in the analysis and design of polymer processing problems. This is operations,......, such as thermoforming, blow moulding, compression moulding, gas-assisted injection moulding, simultaneous multi-component injection moulding....

"3D fusion" echocardiography improves 3D left ventricular assessment: comparison with 2D contrast echocardiography.

Science.gov (United States)

Augustine, Daniel; Yaqub, Mohammad; Szmigielski, Cezary; Lima, Eduardo; Petersen, Steffen E; Becher, Harald; Noble, J Alison; Leeson, Paul

2015-02-01

Three-dimensional fusion echocardiography (3DFE) is a novel postprocessing approach that utilizes imaging data acquired from multiple 3D acquisitions. We assessed image quality, endocardial border definition, and cardiac wall motion in patients using 3DFE compared to standard 3D images (3D) and results obtained with contrast echocardiography (2DC). Twenty-four patients (mean age 66.9 ± 13 years, 17 males, 7 females) undergoing 2DC had three, noncontrast, 3D apical volumes acquired at rest. Images were fused using an automated image fusion approach. Quality of the 3DFE was compared to both 3D and 2DC based on contrast-to-noise ratio (CNR) and endocardial border definition. We then compared clinical wall-motion score index (WMSI) calculated from 3DFE and 3D to those obtained from 2DC images. Fused 3D volumes had significantly improved CNR (8.92 ± 1.35 vs. 6.59 ± 1.19, P echocardiography (1.06 ± 0.09 vs. 1.07 ± 0.15, P = 0.69), whereas unfused images produced significantly more variable results (1.19 ± 0.30). This was confirmed by a better intraclass correlation coefficient (ICC 0.72; 95% CI 0.32-0.88) relative to comparisons with unfused images (ICC 0.56; 95% CI 0.02-0.81). 3DFE significantly improves left ventricular image quality compared to unfused 3D in a patient population and allows noncontrast assessment of wall motion that approaches that achieved with 2D contrast echocardiography. © 2014, Wiley Periodicals, Inc.

A 2D driven 3D vessel segmentation algorithm for 3D digital subtraction angiography data

International Nuclear Information System (INIS)

Spiegel, M; Hornegger, J; Redel, T; Struffert, T; Doerfler, A

2011-01-01

Cerebrovascular disease is among the leading causes of death in western industrial nations. 3D rotational angiography delivers indispensable information on vessel morphology and pathology. Physicians make use of this to analyze vessel geometry in detail, i.e. vessel diameters, location and size of aneurysms, to come up with a clinical decision. 3D segmentation is a crucial step in this pipeline. Although a lot of different methods are available nowadays, all of them lack a method to validate the results for the individual patient. Therefore, we propose a novel 2D digital subtraction angiography (DSA)-driven 3D vessel segmentation and validation framework. 2D DSA projections are clinically considered as gold standard when it comes to measurements of vessel diameter or the neck size of aneurysms. An ellipsoid vessel model is applied to deliver the initial 3D segmentation. To assess the accuracy of the 3D vessel segmentation, its forward projections are iteratively overlaid with the corresponding 2D DSA projections. Local vessel discrepancies are modeled by a global 2D/3D optimization function to adjust the 3D vessel segmentation toward the 2D vessel contours. Our framework has been evaluated on phantom data as well as on ten patient datasets. Three 2D DSA projections from varying viewing angles have been used for each dataset. The novel 2D driven 3D vessel segmentation approach shows superior results against state-of-the-art segmentations like region growing, i.e. an improvement of 7.2% points in precision and 5.8% points for the Dice coefficient. This method opens up future clinical applications requiring the greatest vessel accuracy, e.g. computational fluid dynamic modeling.

Increased excitability of spinal pain reflexes and altered frequency-dependent modulation in the dopamine D3-receptor knockout mouse.

Science.gov (United States)

Keeler, Benjamin E; Baran, Christine A; Brewer, Kori L; Clemens, Stefan

2012-12-01

Frequency-dependent modulation and dopamine (DA) receptors strongly modulate neural circuits in the spinal cord. Of the five known DA receptor subtypes, the D3 receptor has the highest affinity to DA, and D3-mediated actions are mainly inhibitory. Using an animal model of spinal sensorimotor dysfunction, the D3 receptor knockout mouse (D3KO), we investigated the physiological consequences of D3 receptor dysfunction on pain-associated signaling pathways in the spinal cord, the initial integration site for the processing of pain signaling. In the D3KO spinal cord, inhibitory actions of DA on the proprioceptive monosynaptic stretch reflex are converted from depression to facilitation, but its effects on longer-latency and pain-associated reflex responses and the effects of FM have not been studied. Using behavioral approaches in vivo, we found that D3KO animals exhibit reduced paw withdrawal latencies to thermal pain stimulation (Hargreaves' test) over wild type (WT) controls. Electrophysiological and pharmacological approaches in the isolated spinal cord in vitro showed that constant current stimulation of dorsal roots at a pain-associated frequency was associated with a significant reduction in the frequency-dependent modulation of longer-latency reflex (LLRs) responses but not monosynaptic stretch reflexes (MSRs) in D3KO. Application of the D1 and D2 receptor agonists and the voltage-gated calcium-channel ligand, pregabalin, but not DA, was able to restore the frequency-dependent modulation of the LLR in D3KO to WT levels. Thus we demonstrate that nociception-associated LLRs and proprioceptive MSRs are differentially modulated by frequency, dopaminergics and the Ca(2+) channel ligand, pregabalin. Our data suggest a role for the DA D3 receptor in pain modulation and identify the D3KO as a possible model for increased nociception. Copyright © 2012 Elsevier Inc. All rights reserved.

DYNA3D2000*, Explicit 3-D Hydrodynamic FEM Program

International Nuclear Information System (INIS)

Lin, J.

2002-01-01

1 - Description of program or function: DYNA3D2000 is a nonlinear explicit finite element code for analyzing 3-D structures and solid continuum. The code is vectorized and available on several computer platforms. The element library includes continuum, shell, beam, truss and spring/damper elements to allow maximum flexibility in modeling physical problems. Many materials are available to represent a wide range of material behavior, including elasticity, plasticity, composites, thermal effects and rate dependence. In addition, DYNA3D has a sophisticated contact interface capability, including frictional sliding, single surface contact and automatic contact generation. 2 - Method of solution: Discretization of a continuous model transforms partial differential equations into algebraic equations. A numerical solution is then obtained by solving these algebraic equations through a direct time marching scheme. 3 - Restrictions on the complexity of the problem: Recent software improvements have eliminated most of the user identified limitations with dynamic memory allocation and a very large format description that has pushed potential problem sizes beyond the reach of most users. The dominant restrictions remain in code execution speed and robustness, which the developers constantly strive to improve

3D Hand Gesture Analysis through a Real-Time Gesture Search Engine

Directory of Open Access Journals (Sweden)

Shahrouz Yousefi

2015-06-01

Full Text Available 3D gesture recognition and tracking are highly desired features of interaction design in future mobile and smart environments. Specifically, in virtual/augmented reality applications, intuitive interaction with the physical space seems unavoidable and 3D gestural interaction might be the most effective alternative for the current input facilities such as touchscreens. In this paper, we introduce a novel solution for real-time 3D gesture-based interaction by finding the best match from an extremely large gesture database. This database includes images of various articulated hand gestures with the annotated 3D position/orientation parameters of the hand joints. Our unique matching algorithm is based on the hierarchical scoring of the low-level edge-orientation features between the query frames and database and retrieving the best match. Once the best match is found from the database in each moment, the pre-recorded 3D motion parameters can instantly be used for natural interaction. The proposed bare-hand interaction technology performs in real time with high accuracy using an ordinary camera.

Simulator sickness analysis of 3D video viewing on passive 3D TV

Science.gov (United States)

Brunnström, K.; Wang, K.; Andrén, B.

2013-03-01

The MPEG 3DV project is working on the next generation video encoding standard and in this process a call for proposal of encoding algorithms was issued. To evaluate these algorithm a large scale subjective test was performed involving Laboratories all over the world. For the participating Labs it was optional to administer a slightly modified Simulator Sickness Questionnaire (SSQ) from Kennedy et al (1993) before and after the test. Here we report the results from one Lab (Acreo) located in Sweden. The videos were shown on a 46 inch film pattern retarder 3D TV, where the viewers were using polarized passive eye-glasses to view the stereoscopic 3D video content. There were 68 viewers participating in this investigation in ages ranges from 16 to 72, with one third females. The questionnaire was filled in before and after the test, with a viewing time ranging between 30 min to about one and half hour, which is comparable to a feature length movie. The SSQ consists of 16 different symptoms that have been identified as important for indicating simulator sickness. When analyzing the individual symptoms it was found that Fatigue, Eye-strain, Difficulty Focusing and Difficulty Concentrating were significantly worse after than before. SSQ was also analyzed according to the model suggested by Kennedy et al (1993). All in all this investigation shows a statistically significant increase in symptoms after viewing 3D video especially related to visual or Oculomotor system.

Time-dependent hydrogen ionisation in 3D simulations of the solar chromosphere. Methods and first results

NARCIS (Netherlands)

Leenaarts, J.; Wedemeyer-Bohm, S.

2006-01-01

Context. The hydrogen ionisation degree deviates substantially from statistical equilibrium under the conditions of the solar chromosphere. A realistic description of this atmospheric layer thus must account for time-dependent non-equilibrium effects. Aims. Advancing the realism of numerical

d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway

Directory of Open Access Journals (Sweden)

Ziwei Miao

2017-01-01

Full Text Available d,l-Sulforaphane (SFN, a synthetic analogue of broccoli-derived isomer l-SFN, exerts cytotoxic effects on multiple tumor cell types through different mechanisms and is more potent than the l-isomer at inhibiting cancer growth. However, the means by which SFN impairs glioblastoma (GBM cells remains poorly understood. In this study, we investigated the anti-cancer effect of SFN in GBM cells and determined the underlying molecular mechanisms. Cell viability assays, flow cytometry, immunofluorescence, and Western blot results revealed that SFN could induced apoptosis of GBM cells in a dose- and time-dependent manner, via up-regulation of caspase-3 and Bax, and down-regulation of Bcl-2. Mechanistically, SFN treatment led to increase the intracellular reactive oxygen species (ROS level in GBM cells. Meanwhile, SFN also suppressed both constitutive and IL-6-induced phosphorylation of STAT3, and the activation of upstream JAK2 and Src tyrosine kinases, dose- and time-dependently. Moreover, blockage of ROS production by using the ROS inhibitor N-acetyl-l-cysteine totally reversed SFN-mediated down-regulation of JAK2/Src-STAT3 signaling activation and the subsequent effects on apoptosis by blocking the induction of apoptosis-related genes in GBM cells. Taken together, our data suggests that SFN induces apoptosis in GBM cells via ROS-dependent inactivation of STAT3 phosphorylation. These findings motivate further evaluation of SFN as a cancer chemopreventive agent in GBM treatment.

The coupled code system TORT-TD/ATTICA3D for 3-D transient analysis of pebble-bed HTGR

International Nuclear Information System (INIS)

Seubert, A.; Sureda, A.; Lapins, J.; Buck, M.; Laurien, E.; Bader, J.; EnBW Kernkraft GmbH, Philippsburg

2012-01-01

This paper describes the time-dependent 3-D discrete-ordinates based coupled code system TORT-TD/ATTICA3D and its application to HTGR of pebble bed type. TORT-TD/ATTICA3D is represented by a single executable and adapts the so-called internal coupling approach. Three-dimensional distributions of temperatures from ATTICA3D and power density from TORT-TD are efficiently exchanged by direct memory access of array elements via interface routines. Applications of TORT-TD/ATTICA3D to three transients based on the PBMR-400 benchmark (total and partial control rod withdrawal and cold helium ingress) and the full power steady state of the HTR-10 are presented. For the partial control rod withdrawal, 3-D effects of local neutron flux redistributions are clearly identified. The results are very promising and demonstrate that the coupled code system TORT-TD/ATTICA3D may represent a key component in a future comprehensive 3-D code system for HTGR of pebble bed type. (orig.)

Measurement of the Time Dependence of Neutron Slowing-Down and Therma in Heavy Water

Energy Technology Data Exchange (ETDEWEB)

Moeller, E

1966-03-15

The behaviour of neutrons during their slowing-down and thermalization in heavy water has been followed on the time scale by measurements of the time-dependent rate of reaction between the flux and the three spectrum indicators indium, cadmium and gadolinium. The space dependence of the reaction rate curves has also been studied. The time-dependent density at 1.46 eV is well reproduced by a function, given by von Dardel, and a time for the maximum density of 7.1 {+-} 0.3 {mu}s has been obtained for this energy in deuterium gas in agreement with the theoretical value of 7.2 {mu}s. The spatial variation of this time is in accord with the calculations by Claesson. The slowing- down time to 0.2 eV has been found to be 16.3 {+-}2.4 {mu}s. The approach to the equilibrium spectrum takes place with a time constant of 33 {+-}4 {mu}s, and the equilibrium has been established after about 200 {mu}s. Comparison of the measured curves for cadmium and gadolinium with multigroup calculations of the time-dependent flux and reaction rate show the superiority of the scattering models for heavy water of Butler and of Brown and St. John over the mass 2 gas model. The experiment has been supplemented with Monte Carlo calculations of the slowing down time.

Measurement of the Time Dependence of Neutron Slowing-Down and Therma in Heavy Water

International Nuclear Information System (INIS)

Moeller, E.

1966-03-01

The behaviour of neutrons during their slowing-down and thermalization in heavy water has been followed on the time scale by measurements of the time-dependent rate of reaction between the flux and the three spectrum indicators indium, cadmium and gadolinium. The space dependence of the reaction rate curves has also been studied. The time-dependent density at 1.46 eV is well reproduced by a function, given by von Dardel, and a time for the maximum density of 7.1 ± 0.3 μs has been obtained for this energy in deuterium gas in agreement with the theoretical value of 7.2 μs. The spatial variation of this time is in accord with the calculations by Claesson. The slowing- down time to 0.2 eV has been found to be 16.3 ±2.4 μs. The approach to the equilibrium spectrum takes place with a time constant of 33 ±4 μs, and the equilibrium has been established after about 200 μs. Comparison of the measured curves for cadmium and gadolinium with multigroup calculations of the time-dependent flux and reaction rate show the superiority of the scattering models for heavy water of Butler and of Brown and St. John over the mass 2 gas model. The experiment has been supplemented with Monte Carlo calculations of the slowing down time

UV dependent vitamin D syntheses. UV exposure time balancing for optimum production of the vitamins D3 status in the human body. Final report; UV-abhaengige Vitamin D Synthese. Bilanzierung der Expositionszeit durch UV zur Produktion des optimalen Vitamin D{sub 3}-Bedarfes im menschlichen Koerper. Schlussbericht

Energy Technology Data Exchange (ETDEWEB)

Knuschke, P.; Lehmann, B.; Pueschel, A.; Roensch, H.

2012-10-15

UV-dependent vitamin D{sub 3} synthesis - balancing of UV exposure time and the production of an optimal vitamin D{sub 3} status in men The adverse health effects on human skin and eyes by UV radiation have been well known for years. They are known to the public, too. Increased exposures by the UV-B fraction of solar radiation cause e.g. sun burn as an acute skin reaction or an increased risk on skin cancer as a chronic effect. Radiation of the same spectral UV-B range is necessary to induce the essential vitamin D metabolism in men. The UV-induced vitamin D synthesis in the skin supplies the body with more than 90 % while our typical nutrition contributes no more than 10 %. These photobiological effects are diametrically opposed. Therefore, up to now there are contradictory recommendations to the public concerning the health effects of solar UV exposure. The aim of this research project was to evaluate the quantitative and qualitative relations of UV exposure and the vitamin D status in men taking into account different conditions in the population. In result, well-balanced recommendations on optimal UV exposures for the different fractions of the population should be elaborated, realizing health protection aspects against detrimental UV effects. A literature survey (updated in 2011) summarizes the current knowledge on the vitamin D metabolism, on the effects of the hormone vitamin D and on the stage of the current discussion on the optimal vitamin D status. In a number of studies of this project the effects of UV exposure on the vitamin D status (25OH-vitamin D{sub 3} und 1,25OH-vitamin D{sub 3}) were investigated. Exposure parameters were the photobiologically effective UV dose (with respect to the minimal erythema dose MED = individual sun burn dose in each investigated volunteer) and the extent of the exposed skin area: face and hands (like everyday conditions) or whole body respectively. Serial UV exposures were applied by natural solar UV radiation or by

Beyond Born-Oppenheimer theory for ab initio constructed diabatic potential energy surfaces of singlet H3+ to study reaction dynamics using coupled 3D time-dependent wave-packet approach.

Science.gov (United States)

Ghosh, Sandip; Mukherjee, Saikat; Mukherjee, Bijit; Mandal, Souvik; Sharma, Rahul; Chaudhury, Pinaki; Adhikari, Satrajit

2017-08-21

The workability of beyond Born-Oppenheimer theory to construct diabatic potential energy surfaces (PESs) of a charge transfer atom-diatom collision process has been explored by performing scattering calculations to extract accurate integral cross sections (ICSs) and rate constants for comparison with most recent experimental quantities. We calculate non-adiabatic coupling terms among the lowest three singlet states of H 3 + system (1 1 A ' , 2 1 A ' , and 3 1 A ' ) using MRCI level of calculation and solve the adiabatic-diabatic transformation equation to formulate the diabatic Hamiltonian matrix of the same process [S. Mukherjee et al., J. Chem. Phys. 141, 204306 (2014)] for the entire region of nuclear configuration space. The nonadiabatic effects in the D + + H 2 reaction has been studied by implementing the coupled 3D time-dependent wave packet formalism in hyperspherical coordinates [S. Adhikari and A. J. C. Varandas, Comput. Phys. Commun. 184, 270 (2013)] with zero and non-zero total angular momentum (J) on such newly constructed accurate (ab initio) diabatic PESs of H 3 + . We have depicted the convergence profiles of reaction probabilities for the reactive non-charge transfer, non-reactive charge transfer, and reactive charge transfer processes for different collisional energies with respect to the helicity (K) and total angular momentum (J) quantum numbers. Finally, total and state-to-state ICSs are calculated as a function of collision energy for the initial rovibrational state (v = 0, j = 0) of the H 2 molecule, and consequently, those quantities are compared with previous theoretical and experimental results.

Strong piezoelectric anisotropy d15/d33 in ⟨111⟩ textured Pb(Mg1/3Nb2/3)O3-Pb(Zr,Ti)O3 ceramics

Science.gov (United States)

Yan, Yongke; Priya, Shashank

2015-08-01

The shear mode piezoelectric properties of Pb(Mg1/3Nb2/3)O3-Pb(Zr,Ti)O3 (PMN-PZT) ceramic with 72% ⟨111⟩ texture were investigated. The piezoelectric anisotropic factor d15/d33 was as high as 8.5 in ⟨111⟩ textured ceramic as compared to 2.0 in random counterpart. The high d15/d33 indicates the "rotator" ferroelectric characteristics of PMN-PZT system and suggests that the large shear piezoelectric response contributes towards the high longitudinal piezoelectric response (d33) in non-polar direction (d33 = 1100 pC/N in ⟨001⟩ textured ceramic vs. d33 = 112 pC/N in ⟨111⟩ textured ceramic).

Autonomous and 3D real-time multi-beam manipulation in a microfluidic environment

DEFF Research Database (Denmark)

Perch-Nielsen, I.; Rodrigo, P.J.; Alonzo, C.A.

2006-01-01

The Generalized Phase Contrast (GPC) method of optical 3D manipulation has previously been used for controlled spatial manipulation of live biological specimen in real-time. These biological experiments were carried out over a time-span of several hours while an operator intermittently optimized...... the optical system. Here we present GPC-based optical micromanipulation in a microfluidic system where trapping experiments are computer-automated and thereby capable of running with only limited supervision. The system is able to dynamically detect living yeast cells using a computer-interfaced CCD camera......, and respond to this by instantly creating traps at positions of the spotted cells streaming at flow velocities that would be difficult for a human operator to handle. With the added ability to control flow rates, experiments were also carried out to confirm the theoretically predicted axially dependent...

tavg3_3d_chm_Fe: MERRA Chem 3D IAU, Precip Mass Flux, Time average 3-hourly 1.25 x 1 degree V5.2.0 (MAT3FECHM) at GES DISC

Data.gov (United States)

National Aeronautics and Space Administration — The MAT3FECHM or tavg3_3d_chm_Fe data product is the MERRA Data Assimilation System Chemistry 3-Dimensional chemistry on layers edges that is time averaged, 3D model...

Real-Time 3D Motion capture by monocular vision and virtual rendering

OpenAIRE

Gomez Jauregui , David Antonio; Horain , Patrick

2012-01-01

International audience; Avatars in networked 3D virtual environments allow users to interact over the Internet and to get some feeling of virtual telepresence. However, avatar control may be tedious. Motion capture systems based on 3D sensors have recently reached the consumer market, but webcams and camera-phones are more widespread and cheaper. The proposed demonstration aims at animating a user's avatar from real time 3D motion capture by monoscopic computer vision, thus allowing virtual t...

Quantitative determination of spin-dependent quasiparticle renormalization in ferromagnetic 3d metals

Energy Technology Data Exchange (ETDEWEB)

Sanchez-Barriga, Jaime; Varykhalov, Andrei; Fink, Joerg; Rader, Oliver; Duerr, Hermann; Eberhardt, Wolfgang [Bessy GmbH, Berlin (Germany)

2008-07-01

Spin dependent low-energy electronic excitations in 3d ferromagnets are of special interest due to the need of a microscopic understanding of the electronic structure of solids. Low-energy electrons (or holes) become dressed by a cloud of excitations resulting in quasiparticles of a finite lifetime and a different effective mass. These type of excitations have been studied by many theoretical methods, and it has been found that because of many body effects no sharp quasiparticle peaks exist for binding energies larger than 2 eV. Interestingly, it has been shown that strong correlation effects could particularly affect majority spin electrons, leading to a pronounced damping of quasiparticles at binding energies around 2 eV and above. In order to give an experimental corroboration to these findings, we have performed a systematic study of the spin-dependent quasiparticle lifetime and band structure of ferromagnetic 3d transition metal surfaces by means of spin and angle-resolved photoemission spectroscopy. On hcp Co(0001), fcc Ni(111) and bcc Fe(110), we have found a more pronounced renormalization of the majority spin quasiparticle spectral weight going from Ni to Co which are both strong ferromagnets. For Fe, a weak ferromagnet, such a process becomes more prominent in the minority channel.

MINARET: Towards a time-dependent neutron transport parallel solver

International Nuclear Information System (INIS)

Baudron, A.M.; Lautard, J.J.; Maday, Y.; Mula, O.

2013-01-01

We present the newly developed time-dependent 3D multigroup discrete ordinates neutron transport solver that has recently been implemented in the MINARET code. The solver is the support for a study about computing acceleration techniques that involve parallel architectures. In this work, we will focus on the parallelization of two of the variables involved in our equation: the angular directions and the time. This last variable has been parallelized by a (time) domain decomposition method called the para-real in time algorithm. (authors)

Real-Time 3D Visualization

Science.gov (United States)

1997-01-01

Butler Hine, former director of the Intelligent Mechanism Group (IMG) at Ames Research Center, and five others partnered to start Fourth Planet, Inc., a visualization company that specializes in the intuitive visual representation of dynamic, real-time data over the Internet and Intranet. Over a five-year period, the then NASA researchers performed ten robotic field missions in harsh climes to mimic the end- to-end operations of automated vehicles trekking across another world under control from Earth. The core software technology for these missions was the Virtual Environment Vehicle Interface (VEVI). Fourth Planet has released VEVI4, the fourth generation of the VEVI software, and NetVision. VEVI4 is a cutting-edge computer graphics simulation and remote control applications tool. The NetVision package allows large companies to view and analyze in virtual 3D space such things as the health or performance of their computer network or locate a trouble spot on an electric power grid. Other products are forthcoming. Fourth Planet is currently part of the NASA/Ames Technology Commercialization Center, a business incubator for start-up companies.

Lagrangian Finite Element Method for 3D Time-Dependent Viscoelastic Flow Computations using Integral Models

DEFF Research Database (Denmark)

Rasmussen, Henrik Koblitz

2000-01-01

The 3D-LIM has as yet been used to simulate the following two three-dimensional problems. First, the method has been used to simulete for viscoelastic end-plate instability that occurs under certain conditions in the transient filament stretching apparatus for pressure sensitive adhesives (polyme...

time of arrival 3-d position estimation using minimum ads-b receiver ...

African Journals Online (AJOL)

HOD

The location from which a signal is transmitted can be estimated using the time it takes to be detected at a receiver. The difference between transmission time and the detection time is known as time of arrival (TOA). In this work, an algorithm for 3-dimensional (3-D) position estimation (PE) of an emitter using the minimum ...

Holovideo: Real-time 3D range video encoding and decoding on GPU

Science.gov (United States)

Karpinsky, Nikolaus; Zhang, Song

2012-02-01

We present a 3D video-encoding technique called Holovideo that is capable of encoding high-resolution 3D videos into standard 2D videos, and then decoding the 2D videos back into 3D rapidly without significant loss of quality. Due to the nature of the algorithm, 2D video compression such as JPEG encoding with QuickTime Run Length Encoding (QTRLE) can be applied with little quality loss, resulting in an effective way to store 3D video at very small file sizes. We found that under a compression ratio of 134:1, Holovideo to OBJ file format, the 3D geometry quality drops at a negligible level. Several sets of 3D videos were captured using a structured light scanner, compressed using the Holovideo codec, and then uncompressed and displayed to demonstrate the effectiveness of the codec. With the use of OpenGL Shaders (GLSL), the 3D video codec can encode and decode in realtime. We demonstrated that for a video size of 512×512, the decoding speed is 28 frames per second (FPS) with a laptop computer using an embedded NVIDIA GeForce 9400 m graphics processing unit (GPU). Encoding can be done with this same setup at 18 FPS, making this technology suitable for applications such as interactive 3D video games and 3D video conferencing.

Time-dependent behavior of concrete

International Nuclear Information System (INIS)

Pfeiffer, P.A.; Tanabe, Tada-aki

1992-01-01

This paper is a condensed version of the material presented at the International Workshop on Finite Element Analysis of Reinforced Concrete, Session 4 -- Time Dependent Behavior, held at Columbia University, New York on June 3--6, 1991. Dr. P.A. Pfeiffer presented recent developments in time-dependent behavior of concrete and Professor T. Tanabe presented a review of research in Japan on time-dependent behavior of concrete. The paper discusses the recent research of time-dependent behavior of concrete in the past few years. 6 refs

A real-time 3D scanning system for pavement distortion inspection

International Nuclear Information System (INIS)

Li, Qingguang; Yao, Ming; Yao, Xun; Xu, Bugao

2010-01-01

Pavement distortions, such as rutting and shoving, are the common pavement distress problems that need to be inspected and repaired in a timely manner to ensure ride quality and traffic safety. This paper introduces a real-time, low-cost inspection system devoted to detecting these distress features using high-speed 3D transverse scanning techniques. The detection principle is the dynamic generation and characterization of the 3D pavement profile based on structured light triangulation. To improve the accuracy of the system, a multi-view coplanar scheme is employed in the calibration procedure so that more feature points can be used and distributed across the field of view of the camera. A sub-pixel line extraction method is applied for the laser stripe location, which includes filtering, edge detection and spline interpolation. The pavement transverse profile is then generated from the laser stripe curve and approximated by line segments. The second-order derivatives of the segment endpoints are used to identify the feature points of possible distortions. The system can output the real-time measurements and 3D visualization of rutting and shoving distress in a scanned pavement

Lagrangian finite element method for 3D time-dependent non-isothermal flow of K-BKZ fluids

DEFF Research Database (Denmark)

Román Marín, José Manuel; Rasmussen, Henrik K.

2009-01-01

equation is replaced with a temperature dependent pseudo time. The spatial coordinate system attached to the particles is discretized by 10-node quadratic tetrahedral elements using Cartesian coordinates. The temperature and the pressure are discretized by 10-node quadratic and linear interpolation...... utilizing an implicit variable step backwards differencing (BDF2) scheme, obtaining second order convergence of the temperature in time. A quadratic interpolation in time is applied to approximate the time integral in the K-BKZ equation. This type of scheme ensures third order accuracy with respect......, respectively, in the tetrahedral particle elements. The spatial discretization of the governing equations follows a mixed Galerkin finite element method. This type of scheme ensures third order accuracy with respect to the discretization of spatial dimension. The temperature equation is solved in time...

BranchAnalysis2D/3D automates morphometry analyses of branching structures.

Science.gov (United States)

Srinivasan, Aditya; Muñoz-Estrada, Jesús; Bourgeois, Justin R; Nalwalk, Julia W; Pumiglia, Kevin M; Sheen, Volney L; Ferland, Russell J

2018-01-15

Morphometric analyses of biological features have become increasingly common in recent years with such analyses being subject to a large degree of observer bias, variability, and time consumption. While commercial software packages exist to perform these analyses, they are expensive, require extensive user training, and are usually dependent on the observer tracing the morphology. To address these issues, we have developed a broadly applicable, no-cost ImageJ plugin we call 'BranchAnalysis2D/3D', to perform morphometric analyses of structures with branching morphologies, such as neuronal dendritic spines, vascular morphology, and primary cilia. Our BranchAnalysis2D/3D algorithm allows for rapid quantification of the length and thickness of branching morphologies, independent of user tracing, in both 2D and 3D data sets. We validated the performance of BranchAnalysis2D/3D against pre-existing software packages using trained human observers and images from brain and retina. We found that the BranchAnalysis2D/3D algorithm outputs results similar to available software (i.e., Metamorph, AngioTool, Neurolucida), while allowing faster analysis times and unbiased quantification. BranchAnalysis2D/3D allows inexperienced observers to output results like a trained observer but more efficiently, thereby increasing the consistency, speed, and reliability of morphometric analyses. Copyright © 2017 Elsevier B.V. All rights reserved.

In Vitro Evaluation of Reversible and Time-Dependent Inhibitory Effects of Kalanchoe crenata on CYP2C19 and CYP3A4 Activities.

Science.gov (United States)

Awortwe, Charles; Manda, Vamshi K; Avonto, Cristina; Khan, Shabana I; Khan, Ikhlas A; Walker, Larry A; Bouic, Patrick J; Rosenkranz, Bernd

2015-01-01

Kalanchoe crenata popularly known as "dog's liver" is used in most African countries for the treatment of chronic diseases such as diabetes, asthma and HIV/AIDS related infections. The evaluation of K. crenata for herb-drug interactions has not been reported. This study therefore aims to evaluate the risk of K. crenata for herb-drug interaction in vitro. Crude methanol and fractions of K. crenata were incubated and preincubated with recombinant human CYP2C19 and CYP3A4. Comparative studies were conducted in both human liver microsomes and recombinant human CYP to ascertain the inhibition profile of the crude extract and the various fractions. The cocktail approach of recombinant human CYPs was conducted to confirm the inhibition potential of the fractions in the presence of other CYPs. The results showed significant time-dependent inhibition of tested samples on CYP3A4 with crude methanol (39KC), fractions 45A, 45B and 45D given IC50 fold decrease of 3.29, 2.26, 1.91 and 1.49, respective. Time dependent kinetic assessment of 39KC and 45D showed KI and kinact values for 39KC as 1.77 µg/mL and 0.091 min(-1) while that of 45D were 6.45 µg/mL and 0.024 min(-1), respectively. Determination of kinact based on IC50 calculations yielded 0.015 and 0.04 min(-1) for 39KC and 45D, respectively. Cocktail approach exhibited fold decreases in IC50 for all test fractions on CYP3A4 within the ranges of 2.10 - 4.10. At least one phytoconstituent in the crude methanol extract of Kalanchoe crenata is a reversible and time-dependent inhibitor of CYP3A4.

Analysis of intra-fraction prostate motion and derivation of duration-dependent margins for radiotherapy using real-time 4D ultrasound

Directory of Open Access Journals (Sweden)

Eric Pei Ping Pang

2018-01-01

Full Text Available Background and purpose: During radiotherapy, prostate motion changes over time. Quantifying and accounting for this motion is essential. This study aimed to assess intra-fraction prostate motion and derive duration-dependent planning margins for two treatment techniques. Material and methods: A four-dimension (4D transperineal ultrasound Clarity® system was used to track prostate motion. We analysed 1913 fractions from 60 patients undergoing volumetric-modulated arc therapy (VMAT to the prostate. The mean VMAT treatment duration was 3.4 min. Extended monitoring was conducted weekly to simulate motion during intensity-modulated radiation therapy (IMRT treatment (an additional seven minutes. A motion-time trend analysis was conducted and the mean intra-fraction motion between VMAT and IMRT treatments compared. Duration-dependent margins were calculated and anisotropic margins for VMAT and IMRT treatments were derived. Results: There were statistically significant differences in the mean intra-fraction motion between VMAT and the simulated IMRT duration in the inferior (0.1 mm versus 0.3 mm and posterior (−0.2 versus −0.4 mm directions respectively (p ≪ 0.01. An intra-fraction motion trend inferiorly and posteriorly was observed. The recommended minimum anisotropic margins are 1.7 mm/2.7 mm (superior/inferior; 0.8 mm (left/right, 1.7 mm/2.9 mm (anterior/posterior for VMAT treatments and 2.9 mm/4.3 mm (superior/inferior, 1.5 mm (left/right, 2.8 mm/4.8 mm (anterior/posterior for IMRT treatments. Smaller anisotropic margins were required for VMAT compared to IMRT (differences ranging from 1.2 to 1.6 mm superiorly/inferiorly, 0.7 mm laterally and 1.1–1.9 mm anteriorly/posteriorly. Conclusions: VMAT treatment is preferred over IMRT as prostate motion increases with time. Larger margins should be employed in the inferior and posterior directions for both treatment durations. Duration-dependent margins should

tavg3_3d_chm_Fv: MERRA Chem 3D IAU States Cloud Precip, Time average 3-hourly 1.25 x 1.25 degree V5.2.0 (MAT3FVCHM) at GES DISC

Data.gov (United States)

National Aeronautics and Space Administration — The MAT3FVCHM or tavg3_3d_chm_Fv data product is the MERRA Data Assimilation System Chemistry 3-Dimensional chemistry on layers file that is time averaged, 3D model...

Enhanced magnetocaloric properties and critical behavior of (Fe0.72Cr0.28)3Al alloys for near room temperature cooling

Science.gov (United States)

Sharma, V.; Maheshwar Repaka, D. V.; Chaudhary, V.; Ramanujan, R. V.

2017-04-01

Magnetic cooling is an environmentally friendly, energy efficient, thermal management technology relying on high performance magnetocaloric materials (MCM). Current research has focused on low cost, corrosion resistant, rare earth (RE) free MCMs. We report the structural and magnetocaloric properties of novel, low cost, RE free, iron based (Fe0.72Cr0.28)3Al alloys. The arc melted buttons and melt spun ribbons possessed the L21 crystal structure and B2 crystal structure, respectively. A notable enhancement of 33% in isothermal entropy change (-ΔS m) and 25% increase in relative cooling power (RCP) for the ribbons compared to the buttons can be attributed to higher structural disorder in the Fe-Cr and Fe-Al sub-lattices of the B2 structure. The critical behavior was investigated using modified Arrott plots, the Kouvel-Fisher plot and the critical isotherm technique; the critical exponents were found to correspond to the short-range order 3D Heisenberg model. The field and temperature dependent magnetization curves of (Fe0.72Cr0.28)3Al alloys revealed their soft magnetic nature with negligible hysteresis. Thus, these alloys possess promising performance attributes for near room temperature magnetic cooling applications.

Position-dependent radiative transfer as a tool for studying Anderson localization: Delay time, time-reversal and coherent backscattering

Science.gov (United States)

van Tiggelen, B. A.; Skipetrov, S. E.; Page, J. H.

2017-05-01

Previous work has established that the localized regime of wave transport in open media is characterized by a position-dependent diffusion coefficient. In this work we study how the concept of position-dependent diffusion affects the delay time, the transverse confinement, the coherent backscattering, and the time reversal of waves. Definitions of energy transport velocity of localized waves are proposed. We start with a phenomenological model of radiative transfer and then present a novel perturbational approach based on the self-consistent theory of localization. The latter allows us to obtain results relevant for realistic experiments in disordered quasi-1D wave guides and 3D slabs.

Induced tauopathy in a novel 3D-culture model mediates neurodegenerative processes: a real-time study on biochips.

Directory of Open Access Journals (Sweden)

Diana Seidel

Full Text Available Tauopathies including Alzheimer's disease represent one of the major health problems of aging population worldwide. Therefore, a better understanding of tau-dependent pathologies and consequently, tau-related intervention strategies is highly demanded. In recent years, several tau-focused therapies have been proposed with the aim to stop disease progression. However, to develop efficient active pharmaceutical ingredients for the broad treatment of Alzheimer's disease patients, further improvements are necessary for understanding the detailed neurodegenerative processes as well as the mechanism and side effects of potential active pharmaceutical ingredients (API in the neuronal system. In this context, there is a lack of suitable complex in vitro cell culture models recapitulating major aspects of taupathological degenerative processes in sufficient time and reproducible manner.Herewith, we describe a novel 3D SH-SY5Y cell-based, tauopathy model that shows advanced characteristics of matured neurons in comparison to monolayer cultures without the need of artificial differentiation promoting agents. Moreover, the recombinant expression of a novel highly pathologic fourfold mutated human tau variant lead to a fast and emphasized degeneration of neuritic processes. The neurodegenerative effects could be analyzed in real time and with high sensitivity using our unique microcavity array-based impedance spectroscopy measurement system. We were able to quantify a time- and concentration-dependent relative impedance decrease when Alzheimer's disease-like tau pathology was induced in the neuronal 3D cell culture model. In combination with the collected optical information, the degenerative processes within each 3D-culture could be monitored and analyzed. More strikingly, tau-specific regenerative effects caused by tau-focused active pharmaceutical ingredients could be quantitatively monitored by impedance spectroscopy.Bringing together our novel complex 3

Hα EQUIVALENT WIDTHS FROM THE 3D-HST SURVEY: EVOLUTION WITH REDSHIFT AND DEPENDENCE ON STELLAR MASS

International Nuclear Information System (INIS)

Fumagalli, Mattia; Patel, Shannon G.; Franx, Marijn; Labbe, Ivo; Brammer, Gabriel; Van Dokkum, Pieter; Lundgren, Britt; Momcheva, Ivelina; Skelton, Rosalind E.; Whitaker, Katherine E.; Nelson, Erica; Da Cunha, Elisabete; Rix, Hans-Walter; Schmidt, Kasper B.; Kriek, Mariska

2012-01-01

We investigate the evolution of the Hα equivalent width, EW(Hα), with redshift and its dependence on stellar mass, using the first data from the 3D-HST survey, a large spectroscopic Treasury program with the Hubble Space Telescope Wide Field Camera 3. Combining our Hα measurements of 854 galaxies at 0.8 1.8 with little mass dependence. Qualitatively, this measurement is a model-independent confirmation of the evolution of star-forming galaxies with redshift. A quantitative conversion of EW(Hα) to specific star formation rate (sSFR) is model dependent because of differential reddening corrections between the continuum and the Balmer lines. The observed EW(Hα) can be reproduced with the characteristic evolutionary history for galaxies, whose star formation rises with cosmic time to z ∼ 2.5 and then decreases to z = 0. This implies that EW(Hα) rises to 400 Å at z = 8. The sSFR evolves faster than EW(Hα), as the mass-to-light ratio also evolves with redshift. We find that the sSFR evolves as (1 + z) 3.2 , nearly independent of mass, consistent with previous reddening insensitive estimates. We confirm previous results that the observed slope of the sSFR-z relation is steeper than the one predicted by models, but models and observations agree in finding little mass dependence.

2D array transducers for real-time 3D ultrasound guidance of interventional devices

Science.gov (United States)

Light, Edward D.; Smith, Stephen W.

2009-02-01

We describe catheter ring arrays for real-time 3D ultrasound guidance of devices such as vascular grafts, heart valves and vena cava filters. We have constructed several prototypes operating at 5 MHz and consisting of 54 elements using the W.L. Gore & Associates, Inc. micro-miniature ribbon cables. We have recently constructed a new transducer using a braided wiring technology from Precision Interconnect. This transducer consists of 54 elements at 4.8 MHz with pitch of 0.20 mm and typical -6 dB bandwidth of 22%. In all cases, the transducer and wiring assembly were integrated with an 11 French catheter of a Cook Medical deployment device for vena cava filters. Preliminary in vivo and in vitro testing is ongoing including simultaneous 3D ultrasound and x-ray fluoroscopy.

Polarization Dependent Bulk-sensitive Valence Band Photoemission Spectroscopy and Density Functional Theory Calculations: Part I. 3d Transition Metals

Science.gov (United States)

Ueda, Shigenori; Hamada, Ikutaro

2017-12-01

The X-ray polarization dependent valence band HAXPES spectra of 3d transition metals (TMs) of Ti-Zn were measured to investigate the orbital resolved electronic structures by utilizing that the fact the photoionization cross-section of the atomic orbitals strongly depends on the experimental geometry. We have calculated the HAXPES spectra, which correspond to the cross-section weighted densities of states (CSW-DOSs), where the DOSs were obtained by the density functional theory calculations, and we have determined the relative photoionization cross-sections of the 4s and 4p orbitals to the 3d orbital in the 3d TMs. The experimentally obtained bulk-sensitive 3d and 4s DOSs were good agreement with the calculated DOSs in Ti, V, Cr, and Cu. In contrast, the deviations between the experimental and calculated 3d DOSs for Mn, Fe, Co, Ni were found, suggesting that the electron correlation plays an important role in the electronic structures for these materials.

Real-time microscopic 3D shape measurement based on optimized pulse-width-modulation binary fringe projection

Science.gov (United States)

Hu, Yan; Chen, Qian; Feng, Shijie; Tao, Tianyang; Li, Hui; Zuo, Chao

2017-07-01

In recent years, tremendous progress has been made in 3D measurement techniques, contributing to the realization of faster and more accurate 3D measurement. As a representative of these techniques, fringe projection profilometry (FPP) has become a commonly used method for real-time 3D measurement, such as real-time quality control and online inspection. To date, most related research has been concerned with macroscopic 3D measurement, but microscopic 3D measurement, especially real-time microscopic 3D measurement, is rarely reported. However, microscopic 3D measurement plays an important role in 3D metrology and is indispensable in some applications in measuring micro scale objects like the accurate metrology of MEMS components of the final devices to ensure their proper performance. In this paper, we proposed a method which effectively combines optimized binary structured patterns with a number-theoretical phase unwrapping algorithm to realize real-time microscopic 3D measurement. A slight defocusing of our optimized binary patterns can considerably alleviate the measurement error based on four-step phase-shifting FPP, providing the binary patterns with a comparable performance to ideal sinusoidal patterns. The static measurement accuracy can reach 8 μm, and the experimental results of a vibrating earphone diaphragm reveal that our system can successfully realize real-time 3D measurement of 120 frames per second (FPS) with a measurement range of 8~\\text{mm}× 6~\\text{mm} in lateral and 8 mm in depth.

Real-time tracking with a 3D-flow processor array

International Nuclear Information System (INIS)

Crosetto, D.

1993-01-01

The problem of real-time track-finding has been performed to date with CAM (Content Addressable Memories) or with fast coincidence logic, because the processing scheme was though to have much slower performance. Advances in technology together with a new architectural approach make it feasible to also explore the computing technique for real-time track finding thus giving the advantages of implementing algorithms that can find more parameters such as calculate the sagitta, curvature, pt, etc. with respect to the CAM approach. This report describes real-time track finding using a new computing approach technique based on the 3D-flow array processor system. This system consists of a fixed interconnection architexture scheme, allowing flexible algorithm implementation on a scalable platform. The 3D-Flow parallel processing system for track finding is scalable in size and performance by either increasing the number of processors, or increasing the speed or else the number of pipelined stages. The present article describes the conceptual idea and the design stage of the project

Real-time tracking with a 3D-Flow processor array

International Nuclear Information System (INIS)

Crosetto, D.

1993-06-01

The problem of real-time track-finding has been performed to date with CAM (Content Addressable Memories) or with fast coincidence logic, because the processing scheme was thought to have much slower performance. Advances in technology together with a new architectural approach make it feasible to also explore the computing technique for real-time track finding thus giving the advantages of implementing algorithms that can find more parameters such as calculate the sagitta, curvature, pt, etc., with respect to the CAM approach. The report describes real-time track finding using new computing approach technique based on the 3D-Flow array processor system. This system consists of a fixed interconnection architecture scheme, allowing flexible algorithm implementation on a scalable platform. The 3D-Flow parallel processing system for track finding is scalable in size and performance by either increasing the number of processors, or increasing the speed or else the number of pipelined stages. The present article describes the conceptual idea and the design stage of the project

SAM-CE, Time-Dependent 3-D Neutron Transport, Gamma Transport in Complex Geometry by Monte-Carlo

International Nuclear Information System (INIS)

2003-01-01

1 - Nature of physical problem solved: The SAM-CE system comprises two Monte Carlo codes, SAM-F and SAM-A. SAM-F supersedes the forward Monte Carlo code, SAM-C. SAM-A is an adjoint Monte Carlo code designed to calculate the response due to fields of primary and secondary gamma radiation. The SAM-CE system is a FORTRAN Monte Carlo computer code designed to solve the time-dependent neutron and gamma-ray transport equations in complex three-dimensional geometries. SAM-CE is applicable for forward neutron calculations and for forward as well as adjoint primary gamma-ray calculations. In addition, SAM-CE is applicable for the gamma-ray stage of the coupled neutron-secondary gamma ray problem, which may be solved in either the forward or the adjoint mode. Time-dependent fluxes, and flux functionals such as dose, heating, count rates, etc., are calculated as functions of energy, time and position. Multiple scoring regions are permitted and these may be either finite volume regions or point detectors or both. Other scores of interest, e.g., collision and absorption densities, etc., are also made. 2 - Method of solution: A special feature of SAM-CE is its use of the 'combinatorial geometry' technique which affords the user geometric capabilities exceeding those available with other commonly used geometric packages. All nuclear interaction cross section data (derived from the ENDF for neutrons and from the UNC-format library for gamma-rays) are tabulated in point energy meshes. The energy meshes for neutrons are internally derived, based on built-in convergence criteria and user- supplied tolerances. Tabulated neutron data for each distinct nuclide are in unique and appropriate energy meshes. Both resolved and unresolved resonance parameters from ENDF data files are treated automatically, and extremely precise and detailed descriptions of cross section behaviour is permitted. Such treatment avoids the ambiguities usually associated with multi-group codes, which use flux

Real-Time 3d Reconstruction from Images Taken from AN Uav

Science.gov (United States)

Zingoni, A.; Diani, M.; Corsini, G.; Masini, A.

2015-08-01

We designed a method for creating 3D models of objects and areas from two aerial images acquired from an UAV. The models are generated automatically and in real-time, and consist in dense and true-colour reconstructions of the considered areas, which give the impression to the operator to be physically present within the scene. The proposed method only needs a cheap compact camera, mounted on a small UAV. No additional instrumentation is necessary, so that the costs are very limited. The method consists of two main parts: the design of the acquisition system and the 3D reconstruction algorithm. In the first part, the choices for the acquisition geometry and for the camera parameters are optimized, in order to yield the best performance. In the second part, a reconstruction algorithm extracts the 3D model from the two acquired images, maximizing the accuracy under the real-time constraint. A test was performed in monitoring a construction yard, obtaining very promising results. Highly realistic and easy-to-interpret 3D models of objects and areas of interest were produced in less than one second, with an accuracy of about 0.5m. For its characteristics, the designed method is suitable for video-surveillance, remote sensing and monitoring, especially in those applications that require intuitive and reliable information quickly, as disasters monitoring, search and rescue and area surveillance.

Characterization and biodistribution of recombinant and recombinant/chimeric constructs of monoclonal antibody B72.3

International Nuclear Information System (INIS)

Colcher, D.; Milenic, D.; Roselli, M.

1989-01-01

Radiolabeled B72.3 has been administered both i.v. and i.p. in patients with colorectal and ovarian cancer as well as other carcinomas and has been shown to selectively bind to approximately 70-80% of metastatic lesions. Greater than 50% of the patients that have been treated with B72.3 have developed an immunological response to murine IgG after a single injection. In an attempt to minimize the immune response of these patients to the administered murine monoclonal antibody, we developed a recombinant form of the murine B72.3 as well as a recombinant/chimeric antibody, using the variable regions of the murine B72.3 and human heavy chain (gamma 4) and light chain (kappa) constant regions. We report here that both the recombinant B72.3 [rB72.3] and the recombinant/chimeric B72.3 [cB72.3(gamma 4)] IgGs maintain the tissue binding and idiotypic specificity of the native murine IgG. The native B72.3, rB72.3, and cB72.3(gamma 4) IgGs were radiolabeled and the biodistribution of these IgGs was studied in athymic mice bearing human colon carcinoma xenografts (LS-174T). Differences were observed between the cB72.3(gamma 4) and the native B72.3 in the percentage of injected dose/g that localized in the tumor. The somewhat lower absolute amounts of the cB72.3(gamma 4) in the tumor are mostly likely due to the observed more rapid clearance from the blood and body of the mouse as compared to the native B72.3 and rB72.3. All three forms [native B72.3, rB72.3, and cB72.3(gamma 4)] of the IgG, however, were able to localize the colon tumor with similar radiolocalization indices [percentage of injected dose/g in tumor divided by the percentage of injected dose/g in normal tissue

Monitoring the effects of doxorubicin on 3D-spheroid tumor cells in real-time

Directory of Open Access Journals (Sweden)

Baek N

2016-11-01

Full Text Available NamHuk Baek,1,* Ok Won Seo,1,* MinSung Kim,1 John Hulme,2 Seong Soo A An2 1Department of R & D, NanoEntek Inc., Seoul, Republic of Korea; 2Department of BioNano Technology Gachon University, Gyeonggi-do, Republic of Korea *These authors contributed equally to this work Abstract: Recently, increasing numbers of cell culture experiments with 3D spheroids presented better correlating results in vivo than traditional 2D cell culture systems. 3D spheroids could offer a simple and highly reproducible model that would exhibit many characteristics of natural tissue, such as the production of extracellular matrix. In this paper numerous cell lines were screened and selected depending on their ability to form and maintain a spherical shape. The effects of increasing concentrations of doxorubicin (DXR on the integrity and viability of the selected spheroids were then measured at regular intervals and in real-time. In total 12 cell lines, adenocarcinomic alveolar basal epithelial (A549, muscle (C2C12, prostate (DU145, testis (F9, pituitary epithelial-like (GH3, cervical cancer (HeLa, HeLa contaminant (HEp2, embryo (NIH3T3, embryo (PA317, neuroblastoma (SH-SY5Y, osteosarcoma U2OS, and embryonic kidney cells (293T, were screened. Out of the 12, 8 cell lines, NIH3T3, C2C12, 293T, SH-SY5Y, A549, HeLa, PA317, and U2OS formed regular spheroids and the effects of DXR on these structures were measured at regular intervals. Finally, 5 cell lines, A549, HeLa, SH-SY5Y, U2OS, and 293T, were selected for real-time monitoring and the effects of DXR treatment on their behavior were continuously recorded for 5 days. A potential correlation regarding the effects of DXR on spheroid viability and ATP production was measured on days 1, 3, and 5. Cytotoxicity of DXR seemed to occur after endocytosis, since the cellular activities and ATP productions were still viable after 1 day of the treatment in all spheroids, except SH-SY5Y. Both cellular activity and ATP production were

Real-time 3D-surface-guided head refixation useful for fractionated stereotactic radiotherapy

International Nuclear Information System (INIS)

Li Shidong; Liu Dezhi; Yin Gongjie; Zhuang Ping; Geng, Jason

2006-01-01

Accurate and precise head refixation in fractionated stereotactic radiotherapy has been achieved through alignment of real-time 3D-surface images with a reference surface image. The reference surface image is either a 3D optical surface image taken at simulation with the desired treatment position, or a CT/MRI-surface rendering in the treatment plan with corrections for patient motion during CT/MRI scans and partial volume effects. The real-time 3D surface images are rapidly captured by using a 3D video camera mounted on the ceiling of the treatment vault. Any facial expression such as mouth opening that affects surface shape and location can be avoided using a new facial monitoring technique. The image artifacts on the real-time surface can generally be removed by setting a threshold of jumps at the neighboring points while preserving detailed features of the surface of interest. Such a real-time surface image, registered in the treatment machine coordinate system, provides a reliable representation of the patient head position during the treatment. A fast automatic alignment between the real-time surface and the reference surface using a modified iterative-closest-point method leads to an efficient and robust surface-guided target refixation. Experimental and clinical results demonstrate the excellent efficacy of <2 min set-up time, the desired accuracy and precision of <1 mm in isocenter shifts, and <1 deg. in rotation

Topic 5: Time-Dependent Behavior

International Nuclear Information System (INIS)

Pfeiffer, P.A.; Tanabe, Tada-aki

1991-01-01

This chapter is a report of the material presented at the International Workshop on Finite Element Analysis of Reinforced Concrete, Session 4 -- Time Dependent Behavior, held at Columbia University, New York on June 3--6, 1991. Dr. P.A. Pfeiffer presented recent developments in time-dependent behavior of concrete and Professor T. Tanabe presented a review of research in Japan on time-dependent behavior of concrete. The chapter discusses the recent research of time-dependent behavior of concrete in the past few years in both the USA-European and Japanese communities. The author appreciates the valuable information provided by Zdenek P. Bazant in preparing the USA-European Research section

Time Series Analysis of 3D Coordinates Using Nonstochastic Observations

NARCIS (Netherlands)

Velsink, H.

2016-01-01

Adjustment and testing of a combination of stochastic and nonstochastic observations is applied to the deformation analysis of a time series of 3D coordinates. Nonstochastic observations are constant values that are treated as if they were observations. They are used to formulate constraints on

Time Series Analysis of 3D Coordinates Using Nonstochastic Observations

NARCIS (Netherlands)

Hiddo Velsink

2016-01-01

From the article: Abstract Adjustment and testing of a combination of stochastic and nonstochastic observations is applied to the deformation analysis of a time series of 3D coordinates. Nonstochastic observations are constant values that are treated as if they were observations. They are used to

Loading mode dependent effective properties of octet-truss lattice structures using 3D-printing

Science.gov (United States)

Challapalli, Adithya

Cellular materials, often called lattice materials, are increasingly receiving attention for their ultralight structures with high specific strength, excellent impact absorption, acoustic insulation, heat dissipation media and compact heat exchangers. In alignment with emerging additive manufacturing (AM) technology, realization of the structural applications of the lattice materials appears to be becoming faster. Considering the direction dependent material properties of the products with AM, by directionally dependent printing resolution, effective moduli of lattice structures appear to be directionally dependent. In this paper, a constitutive model of a lattice structure, which is an octet-truss with a base material having an orthotropic material property considering AM is developed. In a case study, polyjet based 3D printing material having an orthotropic property with a 9% difference in the principal direction provides difference in the axial and shear moduli in the octet-truss by 2.3 and 4.6%. Experimental validation for the effective properties of a 3D printed octet-truss is done for uniaxial tension and compression test. The theoretical value based on the micro-buckling of truss member are used to estimate the failure strength. Modulus value appears a little overestimate compared with the experiment. Finite element (FE) simulations for uniaxial compression and tension of octettruss lattice materials are conducted. New effective properties for the octet-truss lattice structure are developed considering the observed behavior of the octet-truss structure under macroscopic compression and tension trough simulations.

Comparative study of Nd(3+) emission from 4f2 5d and 4f3 configurations induced by multiphotonic process in YLF, GLF and LLF crystals

International Nuclear Information System (INIS)

Librantz, Andre Felipe Henriques

2000-01-01

Nd 3+ ultraviolet fluorescence induced by multiphotonic laser excitations was studied in Nd-doped YLiF 4 (YLF) and LuLiF 4 (LLF) crystals by using the time resolved spectroscopy technique. The UV luminescences are due to transitions between the 4f 2 5d and the 4f 3 electronic configurations of Nd 3+ ions. The 4f 2 5d configuration can be reached by direct pumping the UV transition or by multiphotonic excitation, both processes give raise to the UV emission band with a structure due to the strong phonon coupling, expected for a 5d orbital involvement in the transition. The multiphotonic excitation process is due to three photons (532 nm) sequential absorptions of 532 nm-photons by metastable levels of the 4f 3 configuration splitted by crystalline local field. The sequential excitation of Nd by the pumping laser is attributed to the 4 I 9/2 +532nm → 4 G 7/2 ground state absorption followed by the 4 G 7/2 +532 nm →2 F 5/2 and 2 F 5/2 +532 nm → 4f 2 5d excited state absorptions. The UV emissions due to 4f 2 5d configuration are parity allowed, having lifetime of 35 ns in contrast to UV emissions from 4f 3 configuration which are induced by two absorption steps and are parity forbidden showing longer lifetime of 8μs and narrow tines. The polarization effects of the UV emissions were studied and their behavior are dependent on the excited state configuration involving or not the 5d orbital. The allowed UV emissions positions were affected by the host variation more than the ones originating from the 4f 3 configuration as expected. The electronic energy of the 4f 2 5d configuration shifts to lower energy when increasing the crystal field. (author)

Rate-Independent Processes with Linear Growth Energies and Time-Dependent Boundary Conditions

Czech Academy of Sciences Publication Activity Database

Kružík, Martin; Zimmer, J.

2012-01-01

Roč. 5, č. 3 (2012), s. 591-604 ISSN 1937-1632 R&D Projects: GA AV ČR IAA100750802 Grant - others:GA ČR(CZ) GAP201/10/0357 Institutional research plan: CEZ:AV0Z10750506 Keywords : concentrations * oscillations * time - dependent boundary conditions * rate-independent evolution Subject RIV: BA - General Mathematics http://library.utia.cas.cz/separaty/2011/MTR/kruzik-rate-independent processes with linear growth energies and time - dependent boundary conditions.pdf

Chloramine-T induced binding of monoclonal antibody B72. 3 to concanavalin-A

Energy Technology Data Exchange (ETDEWEB)

Cole, W.C.; Jhingran, S.G. (Methodist Hospital, Houston, TX (United States) Baylor Coll. of Medicine, Houston, TX (United States))

1993-07-01

The effects of chloramine-T (CT) on monoclonal antibody B72.3 were studied with particular reference to Con-A lectin binding. After exposure to chloramine-T concentrations from 0.8 to 4.0 mg/mL (115-574 mol CT/mol B72.3), B72.3 showed progressive binding to agarose-linked Con-A. This behavior was paralleled by decreasing immunoreactivity and increasing fragmentation and aggregation of B72.3 demonstrated by SDS-PAGE and size exclusion HPLC. (Author).

A 3D moisture-stress FEM analysis for time dependent problems in timber structures

Science.gov (United States)

Fortino, Stefania; Mirianon, Florian; Toratti, Tomi

2009-11-01

This paper presents a 3D moisture-stress numerical analysis for timber structures under variable humidity and load conditions. An orthotropic viscoelastic-mechanosorptive material model is specialized on the basis of previous models. Both the constitutive model and the equations needed to describe the moisture flow across the structure are implemented into user subroutines of the Abaqus finite element code and a coupled moisture-stress analysis is performed for several types of mechanical loads and moisture changes. The presented computational approach is validated by analyzing some wood tests described in the literature and comparing the computational results with the reported experimental data.

The 3D protein of duck hepatitis A virus type 1 binds to a viral genomic 3' UTR and shows RNA-dependent RNA polymerase activity.

Science.gov (United States)

Zhang, Yu; Cao, Qianda; Wang, Mingshu; Jia, Renyong; Chen, Shun; Zhu, Dekang; Liu, Mafeng; Sun, Kunfeng; Yang, Qiao; Wu, Ying; Zhao, Xinxin; Chen, Xiaoyue; Cheng, Anchun

2017-12-01

To explore the RNA-dependent RNA polymerase (RdRP) function of the 3D protein of duck hepatitis A virus type 1 (DHAV-1), the gene was cloned into the pET-32a(+) vector for prokaryotic expression. The 3' untranslated region (3' UTR) of DHAV-1 together with a T7 promoter was cloned into the pMD19-T vector for in vitro transcription of 3' UTR RNA, which was further used as a template in RNA-dependent RNA polymerization. In this study, three methods were applied to analyze the RdRP function of the 3D protein: (1) ammonium molybdate spectrophotometry to detect pyrophosphate produced during polymerization; (2) quantitative reverse transcription PCR (RT-qPCR) to investigate the changes in RNA quantity during polymerization; and (3) electrophoresis mobility shift assay to examine the interaction between the 3D protein and 3' UTR. The results showed the 3D protein was successfully expressed in bacteria culture supernatant in a soluble form, which could be purified by affinity chromatography. In 3D enzymatic activity assays, pyrophosphate and RNA were produced, the amounts of which increased based on approximative kinetics, and binding of the 3D protein to the 3' UTR was observed. These results indicate that prokaryotically expressed soluble DHAV-13D protein can bind to a viral genomic 3' UTR and exhibit RdRP activity.

72-directional display having VGA resolution for high-appearance image generation

Science.gov (United States)

Takaki, Yasuhiro; Dairiki, Takeshi

2006-02-01

The high-density directional display, which was originally developed in order to realize a natural 3D display, is not only a 3D display but also a high-appearance display. The appearances of objects, such as glare and transparency, are the results of the reflection and the refraction of rays. The faithful reproduction of such appearances of objects is impossible using conventional 2D displays because rays diffuse on the display screen. The high-density directional display precisely controls the horizontal ray directions so that it can reproduce the appearances of objects. The fidelity of the reproduction of object appearances depends on the ray angle sampling pitch. The angle sampling pitch is determined by considering the human eye imaging system. In the present study the high-appearance display which has the resolution of 640×400 and emits rays in 72 different horizontal directions with the angle pitch of 0.38° was constructed. Two 72-directional displays were combined, each of which consisted of a high-resolution LCD panel (3,840×2,400) and a slanted lenticular sheet. Two images produced by two displays were superimposed by a half mirror. A slit array was placed at the focal plane of the lenticular sheet for each display to reduce the horizontal image crosstalk in the combined image. The impression analysis shows that the high-appearance display provides higher appearances and presence than the conventional 2D displays do.

Quantitative analysis of pulmonary perfusion using time-resolved parallel 3D MRI - initial results

International Nuclear Information System (INIS)

Fink, C.; Buhmann, R.; Plathow, C.; Puderbach, M.; Kauczor, H.U.; Risse, F.; Ley, S.; Meyer, F.J.

2004-01-01

Purpose: to assess the use of time-resolved parallel 3D MRI for a quantitative analysis of pulmonary perfusion in patients with cardiopulmonary disease. Materials and methods: eight patients with pulmonary embolism or pulmonary hypertension were examined with a time-resolved 3D gradient echo pulse sequence with parallel imaging techniques (FLASH 3D, TE/TR: 0.8/1.9 ms; flip angle: 40 ; GRAPPA). A quantitative perfusion analysis based on indicator dilution theory was performed using a dedicated software. Results: patients with pulmonary embolism or chronic thromboembolic pulmonary hypertension revealed characteristic wedge-shaped perfusion defects at perfusion MRI. They were characterized by a decreased pulmonary blood flow (PBF) and pulmonary blood volume (PBV) and increased mean transit time (MTT). Patients with primary pulmonary hypertension or eisenmenger syndrome showed a more homogeneous perfusion pattern. The mean MTT of all patients was 3.3 - 4.7 s. The mean PBF and PBV showed a broader interindividual variation (PBF: 104-322 ml/100 ml/min; PBV: 8 - 21 ml/100 ml). Conclusion: time-resolved parallel 3D MRI allows at least a semi-quantitative assessment of lung perfusion. Future studies will have to assess the clinical value of this quantitative information for the diagnosis and management of cardiopulmonary disease. (orig.) [de

tavg3_3d_chm_Ne: MERRA Chem 3D IAU C-Grid Edge Mass Flux, Time Average 3-Hourly 0.667 x 0.5 degree V5.2.0 (MAT3NECHM) at GES DISC

Data.gov (United States)

National Aeronautics and Space Administration — The MAT3NECHM or tavg3_3d_chm_Ne data product is the MERRA Data Assimilation System Chemistry 3-Dimensional chemistry on layer Edges that is time averaged, 3D model...

Surface Explorations : 3D Moving Images as Cartographies of Time

NARCIS (Netherlands)

Verhoeff, N.

2016-01-01

Moving images of travel and exploration have a long history. In this essay I will examine how the trope of navigation in 3D moving images can work towards an intimate and haptic encounter with other times and other places – elsewhen and elsewhere. The particular navigational construction of space in

An interactive display system for large-scale 3D models

Science.gov (United States)

Liu, Zijian; Sun, Kun; Tao, Wenbing; Liu, Liman

2018-04-01

With the improvement of 3D reconstruction theory and the rapid development of computer hardware technology, the reconstructed 3D models are enlarging in scale and increasing in complexity. Models with tens of thousands of 3D points or triangular meshes are common in practical applications. Due to storage and computing power limitation, it is difficult to achieve real-time display and interaction with large scale 3D models for some common 3D display software, such as MeshLab. In this paper, we propose a display system for large-scale 3D scene models. We construct the LOD (Levels of Detail) model of the reconstructed 3D scene in advance, and then use an out-of-core view-dependent multi-resolution rendering scheme to realize the real-time display of the large-scale 3D model. With the proposed method, our display system is able to render in real time while roaming in the reconstructed scene and 3D camera poses can also be displayed. Furthermore, the memory consumption can be significantly decreased via internal and external memory exchange mechanism, so that it is possible to display a large scale reconstructed scene with over millions of 3D points or triangular meshes in a regular PC with only 4GB RAM.

Shape optimization for non-Newtonian fluids in time-dependent domains

Czech Academy of Sciences Publication Activity Database

Sokolowski, J.; Stebel, Jan

2014-01-01

Roč. 3, č. 2 (2014), s. 331-348 ISSN 2163-2480 R&D Projects: GA ČR GA201/09/0917 Institutional support: RVO:67985840 Keywords : shape optimization * time - dependent domain * incompressible viscous fluid Subject RIV: BA - General Mathematics Impact factor: 0.373, year: 2014 http://www.aimsciences.org/journals/home.jsp?journalID=25

Shape optimization for non-Newtonian fluids in time-dependent domains

Czech Academy of Sciences Publication Activity Database

Sokolowski, J.; Stebel, Jan

2014-01-01

Roč. 3, č. 2 (2014), s. 331-348 ISSN 2163-2480 R&D Projects: GA ČR GA201/09/0917 Institutional support: RVO:67985840 Keywords : shape optimization * time-dependent domain * incompressible viscous fluid Subject RIV: BA - General Mathematics Impact factor: 0.373, year: 2014 http://www.aimsciences.org/journals/home.jsp?journalID=25

3-D tracking in a miniature time projection chamber

Energy Technology Data Exchange (ETDEWEB)

Vahsen, S.E., E-mail: sevahsen@hawaii.edu [University of Hawaii, 2505 Correa Road, Honolulu, HI 96822 (United States); Hedges, M.T.; Jaegle, I.; Ross, S.J.; Seong, I.S.; Thorpe, T.N.; Yamaoka, J. [University of Hawaii, 2505 Correa Road, Honolulu, HI 96822 (United States); Kadyk, J.A.; Garcia-Sciveres, M. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States)

2015-07-11

The three-dimensional (3-D) detection of millimeter-scale ionization trails is of interest for detecting nuclear recoils in directional fast neutron detectors and in direction-sensitive searches for weakly interacting massive particles (WIMPs), which may constitute the Dark Matter of the universe. We report on performance characterization of a miniature gas target Time Projection Chamber (TPC) where the drift charge is avalanche-multiplied with Gas Electron Multipliers (GEMs) and detected with the ATLAS FE-I3 Pixel Application Specific Integrated Circuit (ASIC). We report on measurements of gain, gain resolution, point resolution, diffusion, angular resolution, and energy resolution with low-energy X-rays, cosmic rays, and alpha particles, using the gases Ar:CO{sub 2} (70:30) and He:CO{sub 2} (70:30) at atmospheric pressure. We discuss the implications for future, larger directional neutron and Dark Matter detectors. With an eye to designing and selecting components for these, we generalize our results into analytical expressions for detector performance whenever possible. We conclude by demonstrating the 3-D directional detection of a fast neutron source.

Use of monoclonal antibody B72.3 in the management of gynecologic malignancies

International Nuclear Information System (INIS)

Simpson, J.; Schlom, J.

1988-01-01

Monoclonal antibodies are currently used in the diagnosis of gynecologic malignancies by way of immunohistochemical assays, serum assays, and in situ radiolocalization of carcinoma lesions. Among them is MAb B72.3, generated against a human tumor-associated antigen (TAG-72). Using immunohistochemical techniques, MAb B72.3 has shown reactivity with 100 percent of common epithelial ovarian carcinomas and endometrial carcinomas and non-reactivity with normal adult tissues, with the exception of normal secretory endometrium. B72.3 appears to be a valuable immunocytologic adjunct, with greater than 90 percent of effusions and fine-needle aspiration biopsies from gynecologic carcinomas showing reactivity. Using a serum assay developed to detect the presence of the TAG-72 antigen, 48 percent of patients with ovarian carcinoma demonstrated TAG-72-positive sera versus 1 percent of control sera. 131 I-labeled MAb B72.3 IgG and gamma scanning have been used for the in situ detection of metastatic carcinoma. Twelve of 15 patients with ovarian carcinoma showed positive gamma scans, and approximately 80 percent of the lesions demonstrated specific localization of the antibody. These studies indicate the potential utility of MAb B72.3 in the diagnosis of gynecologic carcinoma. 57 references

Excitation-energy dependence of the resonant Auger transitions to the 4p4(1D)np (n=5,6) states across the 3d3/2-15p and 3d5/2-16p resonances in Kr

International Nuclear Information System (INIS)

Sankari, A.; Alitalo, S.; Nikkinen, J.; Kivimaeki, A.; Aksela, S.; Aksela, H.; Fritzsche, S.

2007-01-01

The energy dependencies of the intensities and angular distribution parameters β of the resonant Auger final states 4p 4 ( 1 D)np (n=5,6) of Kr were determined experimentally in the excitation-energy region of the overlapping 3d 3/2 -1 5p and 3d 5/2 -1 6p resonances. The experimental results were compared with the outcome of multiconfiguration Dirac-Fock calculations. Combining experimental and calculated results allowed us to study interference effects between the direct and several resonant channels that populate the 4p 4 ( 1 D)np states. The inclusion of the direct channel was crucial in order to reproduce the observed energy behavior of the angular distribution parameters. It was also important to take into account experimentally observed shake transitions

Double dissociation of spike timing-dependent potentiation and depression by subunit-preferring NMDA receptor antagonists in mouse barrel cortex.

Science.gov (United States)

Banerjee, Abhishek; Meredith, Rhiannon M; Rodríguez-Moreno, Antonio; Mierau, Susanna B; Auberson, Yves P; Paulsen, Ole

2009-12-01

Spike timing-dependent plasticity (STDP) is a strong candidate for an N-methyl-D-aspartate (NMDA) receptor-dependent form of synaptic plasticity that could underlie the development of receptive field properties in sensory neocortices. Whilst induction of timing-dependent long-term potentiation (t-LTP) requires postsynaptic NMDA receptors, timing-dependent long-term depression (t-LTD) requires the activation of presynaptic NMDA receptors at layer 4-to-layer 2/3 synapses in barrel cortex. Here we investigated the developmental profile of t-LTD at layer 4-to-layer 2/3 synapses of mouse barrel cortex and studied their NMDA receptor subunit dependence. Timing-dependent LTD emerged in the first postnatal week, was present during the second week and disappeared in the adult, whereas t-LTP persisted in adulthood. An antagonist at GluN2C/D subunit-containing NMDA receptors blocked t-LTD but not t-LTP. Conversely, a GluN2A subunit-preferring antagonist blocked t-LTP but not t-LTD. The GluN2C/D subunit requirement for t-LTD appears to be synapse specific, as GluN2C/D antagonists did not block t-LTD at horizontal cross-columnar layer 2/3-to-layer 2/3 synapses, which was blocked by a GluN2B antagonist instead. These data demonstrate an NMDA receptor subunit-dependent double dissociation of t-LTD and t-LTP mechanisms at layer 4-to-layer 2/3 synapses, and suggest that t-LTD is mediated by distinct molecular mechanisms at different synapses on the same postsynaptic neuron.

Real-Time 3D Tracking and Reconstruction on Mobile Phones.

Science.gov (United States)

Prisacariu, Victor Adrian; Kähler, Olaf; Murray, David W; Reid, Ian D

2015-05-01

We present a novel framework for jointly tracking a camera in 3D and reconstructing the 3D model of an observed object. Due to the region based approach, our formulation can handle untextured objects, partial occlusions, motion blur, dynamic backgrounds and imperfect lighting. Our formulation also allows for a very efficient implementation which achieves real-time performance on a mobile phone, by running the pose estimation and the shape optimisation in parallel. We use a level set based pose estimation but completely avoid the, typically required, explicit computation of a global distance. This leads to tracking rates of more than 100 Hz on a desktop PC and 30 Hz on a mobile phone. Further, we incorporate additional orientation information from the phone's inertial sensor which helps us resolve the tracking ambiguities inherent to region based formulations. The reconstruction step first probabilistically integrates 2D image statistics from selected keyframes into a 3D volume, and then imposes coherency and compactness using a total variational regularisation term. The global optimum of the overall energy function is found using a continuous max-flow algorithm and we show that, similar to tracking, the integration of per voxel posteriors instead of likelihoods improves the precision and accuracy of the reconstruction.

3D-Pathology: a real-time system for quantitative diagnostic pathology and visualisation in 3D

Science.gov (United States)

Gottrup, Christian; Beckett, Mark G.; Hager, Henrik; Locht, Peter

2005-02-01

This paper presents the results of the 3D-Pathology project conducted under the European EC Framework 5. The aim of the project was, through the application of 3D image reconstruction and visualization techniques, to improve the diagnostic and prognostic capabilities of medical personnel when analyzing pathological specimens using transmitted light microscopy. A fully automated, computer-controlled microscope system has been developed to capture 3D images of specimen content. 3D image reconstruction algorithms have been implemented and applied to the acquired volume data in order to facilitate the subsequent 3D visualization of the specimen. Three potential application fields, immunohistology, cromogenic in situ hybridization (CISH) and cytology, have been tested using the prototype system. For both immunohistology and CISH, use of the system furnished significant additional information to the pathologist.

Enhanced magnetocaloric properties and critical behavior of (Fe0.72Cr0.28)3Al alloys for near room temperature cooling

International Nuclear Information System (INIS)

Sharma, V; Maheshwar Repaka, D V; Chaudhary, V; Ramanujan, R V

2017-01-01

Magnetic cooling is an environmentally friendly, energy efficient, thermal management technology relying on high performance magnetocaloric materials (MCM). Current research has focused on low cost, corrosion resistant, rare earth (RE) free MCMs. We report the structural and magnetocaloric properties of novel, low cost, RE free, iron based (Fe 0.72 Cr 0.28 ) 3 Al alloys. The arc melted buttons and melt spun ribbons possessed the L2 1 crystal structure and B2 crystal structure, respectively. A notable enhancement of 33% in isothermal entropy change (−Δ S m ) and 25% increase in relative cooling power (RCP) for the ribbons compared to the buttons can be attributed to higher structural disorder in the Fe–Cr and Fe–Al sub-lattices of the B2 structure. The critical behavior was investigated using modified Arrott plots, the Kouvel–Fisher plot and the critical isotherm technique; the critical exponents were found to correspond to the short-range order 3D Heisenberg model. The field and temperature dependent magnetization curves of (Fe 0.72 Cr 0.28 ) 3 Al alloys revealed their soft magnetic nature with negligible hysteresis. Thus, these alloys possess promising performance attributes for near room temperature magnetic cooling applications. (paper)

3D Simulation of Nano-Imprint Lithography

DEFF Research Database (Denmark)

Román Marín, José Manuel; Rasmussen, Henrik K.; Hassager, Ole

2010-01-01

A proof of concept study of the feasibility of fully three-dimensional (3D) time-dependent simulation of nano-imprint lithography of polymer melt, where the polymer is treated as a structured liquid, has been presented. Considering the flow physics of the polymer as a structured liquid, we have...

FUN3D Manual: 13.3

Science.gov (United States)

Biedron, Robert T.; Carlson, Jan-Renee; Derlaga, Joseph M.; Gnoffo, Peter A.; Hammond, Dana P.; Jones, William T.; Kleb, Bil; Lee-Rausch, Elizabeth M.; Nielsen, Eric J.; Park, Michael A.;

3D Vision Provides Shorter Operative Time and More Accurate Intraoperative Surgical Performance in Laparoscopic Hiatal Hernia Repair Compared With 2D Vision.

Science.gov (United States)

Leon, Piera; Rivellini, Roberta; Giudici, Fabiola; Sciuto, Antonio; Pirozzi, Felice; Corcione, Francesco

2017-04-01

The aim of this study is to evaluate if 3-dimensional high-definition (3D) vision in laparoscopy can prompt advantages over conventional 2D high-definition vision in hiatal hernia (HH) repair. Between September 2012 and September 2015, we randomized 36 patients affected by symptomatic HH to undergo surgery; 17 patients underwent 2D laparoscopic HH repair, whereas 19 patients underwent the same operation in 3D vision. No conversion to open surgery occurred. Overall operative time was significantly reduced in the 3D laparoscopic group compared with the 2D one (69.9 vs 90.1 minutes, P = .006). Operative time to perform laparoscopic crura closure did not differ significantly between the 2 groups. We observed a tendency to a faster crura closure in the 3D group in the subgroup of patients with mesh positioning (7.5 vs 8.9 minutes, P = .09). Nissen fundoplication was faster in the 3D group without mesh positioning ( P = .07). 3D vision in laparoscopic HH repair helps surgeon's visualization and seems to lead to operative time reduction. Advantages can result from the enhanced spatial perception of narrow spaces. Less operative time and more accurate surgery translate to benefit for patients and cost savings, compensating the high costs of the 3D technology. However, more data from larger series are needed to firmly assess the advantages of 3D over 2D vision in laparoscopic HH repair.

A Miniaturized QEPAS Trace Gas Sensor with a 3D-Printed Acoustic Detection Module

Directory of Open Access Journals (Sweden)

Xiaotao Yang

2017-07-01

Full Text Available A 3D printing technique was introduced to a quartz-enhanced photoacoustic spectroscopy (QEPAS sensor and is reported for the first time. The acoustic detection module (ADM was designed and fabricated using the 3D printing technique and the ADM volume was compressed significantly. Furthermore, a small grin lens was used for laser focusing and facilitated the beam adjustment in the 3D-printed ADM. A quartz tuning fork (QTF with a low resonance frequency of 30.72 kHz was used as the acoustic wave transducer and acetylene (C2H2 was chosen as the analyte. The reported miniaturized QEPAS trace gas sensor is useful in actual sensor applications.

Enhancement of Online Robotics Learning Using Real-Time 3D Visualization Technology

Directory of Open Access Journals (Sweden)

Richard Chiou

2010-06-01

Full Text Available This paper discusses a real-time e-Lab Learning system based on the integration of 3D visualization technology with a remote robotic laboratory. With the emergence and development of the Internet field, online learning is proving to play a significant role in the upcoming era. In an effort to enhance Internet-based learning of robotics and keep up with the rapid progression of technology, a 3- Dimensional scheme of viewing the robotic laboratory has been introduced in addition to the remote controlling of the robots. The uniqueness of the project lies in making this process Internet-based, and remote robot operated and visualized in 3D. This 3D system approach provides the students with a more realistic feel of the 3D robotic laboratory even though they are working remotely. As a result, the 3D visualization technology has been tested as part of a laboratory in the MET 205 Robotics and Mechatronics class and has received positive feedback by most of the students. This type of research has introduced a new level of realism and visual communications to online laboratory learning in a remote classroom.

Strain measurement of abdominal aortic aneurysm with real-time 3D ultrasound speckle tracking.

Science.gov (United States)

Bihari, P; Shelke, A; Nwe, T H; Mularczyk, M; Nelson, K; Schmandra, T; Knez, P; Schmitz-Rixen, T

2013-04-01

Abdominal aortic aneurysm rupture is caused by mechanical vascular tissue failure. Although mechanical properties within the aneurysm vary, currently available ultrasound methods assess only one cross-sectional segment of the aorta. This study aims to establish real-time 3-dimensional (3D) speckle tracking ultrasound to explore local displacement and strain parameters of the whole abdominal aortic aneurysm. Validation was performed on a silicone aneurysm model, perfused in a pulsatile artificial circulatory system. Wall motion of the silicone model was measured simultaneously with a commercial real-time 3D speckle tracking ultrasound system and either with laser-scan micrometry or with video photogrammetry. After validation, 3D ultrasound data were collected from abdominal aortic aneurysms of five patients and displacement and strain parameters were analysed. Displacement parameters measured in vitro by 3D ultrasound and laser scan micrometer or video analysis were significantly correlated at pulse pressures between 40 and 80 mmHg. Strong local differences in displacement and strain were identified within the aortic aneurysms of patients. Local wall strain of the whole abdominal aortic aneurysm can be analysed in vivo with real-time 3D ultrasound speckle tracking imaging, offering the prospect of individual non-invasive rupture risk analysis of abdominal aortic aneurysms. Copyright © 2013 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

Multiple matching scheme for broadband 0.72Pb(Mg1/3Nb2/3)O3-0.28PbTiO3 single crystal phased-array transducer

Science.gov (United States)

Lau, S. T.; Li, H.; Wong, K. S.; Zhou, Q. F.; Zhou, D.; Li, Y. C.; Luo, H. S.; Shung, K. K.; Dai, J. Y.

2009-05-01

Lead magnesium niobate-lead titanate single crystal 0.72Pb(Mg1/3Nb2/3)O3-0.28PbTiO3 (abbreviated as PMN-PT) was used to fabricate high performance ultrasonic phased-array transducer as it exhibited excellent piezoelectric properties. In this paper, we focus on the design and fabrication of a low-loss and wide-band transducer for medical imaging applications. A KLM model based simulation software PiezoCAD was used for acoustic design of the transducer including the front-face matching and backing. The calculated results show that the -6 dB transducer bandwidth can be improved significantly by using double λ /8 matching layers and hard backing. A 4.0 MHz PMN-PT transducer array (with 16 elements) was fabricated and tested in a pulse-echo arrangement. A -6 dB bandwidth of 110% and two-way insertion loss of -46.5 dB were achieved.

3D real-time monitoring system for LHD plasma heating experiment

International Nuclear Information System (INIS)

Emoto, M.; Narlo, J.; Kaneko, O.; Komori, A.; Iima, M.; Yamaguchi, S.; Sudo, S.

2001-01-01

The JAVA-based real-time monitoring system has been in use at the National Institute for Fusion Science, Japan, since the end of March 1988 to maintain stable operations. This system utilizes JAVA technology to realize its platform-independent nature. The main programs are written as JAVA applets and provide human-friendly interfaces. In order to enhance the system's easy-recognition nature, a 3D feature is added. Since most of the system is written mainly in JAVA language, we adopted JAVA3D technology, which was easy to incorporate into the current running systems. With this 3D feature, the operator can more easily find the malfunctioning parts of complex instruments, such as LHD vacuum vessels. This feature is also helpful for recognizing physical phenomena. In this paper, we present an example in which the temperature increases of a vacuum vessel after NBI are visualized

Laser nanostructuring 3-D bioconstruction based on carbon nanotubes in a water matrix of albumin

Science.gov (United States)

Gerasimenko, Alexander Y.; Ichkitidze, Levan P.; Podgaetsky, Vitaly M.; Savelyev, Mikhail S.; Selishchev, Sergey V.

2016-04-01

3-D bioconstructions were created using the evaporation method of the water-albumin solution with carbon nanotubes (CNTs) by the continuous and pulsed femtosecond laser radiation. It is determined that the volume structure of the samples created by the femtosecond radiation has more cavities than the one created by the continuous radiation. The average diameter for multi-walled carbon nanotubes (MWCNTs) samples was almost two times higher (35-40 nm) than for single-walled carbon nanotubes (SWCNTs) samples (20-30 nm). The most homogenous 3-D bioconstruction was formed from MWCNTs by the continuous laser radiation. The hardness of such samples totaled up to 370 MPa at the nanoscale. High strength properties and the resistance of the 3-D bioconstructions produced by the laser irradiation depend on the volume nanotubes scaffold forming inside them. The scaffold was formed by the electric field of the directed laser irradiation. The covalent bond energy between the nanotube carbon molecule and the oxygen of the bovine serum albumin aminoacid residue amounts 580 kJ/mol. The 3-D bioconstructions based on MWCNTs and SWCNTs becomes overgrown with the cells (fibroblasts) over the course of 72 hours. The samples based on the both types of CNTs are not toxic for the cells and don't change its normal composition and structure. Thus the 3-D bioconstructions that are nanostructured by the pulsed and continuous laser radiation can be applied as implant materials for the recovery of the connecting tissues of the living body.

Case study: Beauty and the Beast 3D: benefits of 3D viewing for 2D to 3D conversion

Science.gov (United States)

Handy Turner, Tara

2010-02-01

From the earliest stages of the Beauty and the Beast 3D conversion project, the advantages of accurate desk-side 3D viewing was evident. While designing and testing the 2D to 3D conversion process, the engineering team at Walt Disney Animation Studios proposed a 3D viewing configuration that not only allowed artists to "compose" stereoscopic 3D but also improved efficiency by allowing artists to instantly detect which image features were essential to the stereoscopic appeal of a shot and which features had minimal or even negative impact. At a time when few commercial 3D monitors were available and few software packages provided 3D desk-side output, the team designed their own prototype devices and collaborated with vendors to create a "3D composing" workstation. This paper outlines the display technologies explored, final choices made for Beauty and the Beast 3D, wish-lists for future development and a few rules of thumb for composing compelling 2D to 3D conversions.

Position tracking of moving liver lesion based on real-time registration between 2D ultrasound and 3D preoperative images

International Nuclear Information System (INIS)

Weon, Chijun; Hyun Nam, Woo; Lee, Duhgoon; Ra, Jong Beom; Lee, Jae Young

2015-01-01

Purpose: Registration between 2D ultrasound (US) and 3D preoperative magnetic resonance (MR) (or computed tomography, CT) images has been studied recently for US-guided intervention. However, the existing techniques have some limits, either in the registration speed or the performance. The purpose of this work is to develop a real-time and fully automatic registration system between two intermodal images of the liver, and subsequently an indirect lesion positioning/tracking algorithm based on the registration result, for image-guided interventions. Methods: The proposed position tracking system consists of three stages. In the preoperative stage, the authors acquire several 3D preoperative MR (or CT) images at different respiratory phases. Based on the transformations obtained from nonrigid registration of the acquired 3D images, they then generate a 4D preoperative image along the respiratory phase. In the intraoperative preparatory stage, they properly attach a 3D US transducer to the patient’s body and fix its pose using a holding mechanism. They then acquire a couple of respiratory-controlled 3D US images. Via the rigid registration of these US images to the 3D preoperative images in the 4D image, the pose information of the fixed-pose 3D US transducer is determined with respect to the preoperative image coordinates. As feature(s) to use for the rigid registration, they may choose either internal liver vessels or the inferior vena cava. Since the latter is especially useful in patients with a diffuse liver disease, the authors newly propose using it. In the intraoperative real-time stage, they acquire 2D US images in real-time from the fixed-pose transducer. For each US image, they select candidates for its corresponding 2D preoperative slice from the 4D preoperative MR (or CT) image, based on the predetermined pose information of the transducer. The correct corresponding image is then found among those candidates via real-time 2D registration based on a

[Size dependent SERS activity of gold nanoparticles studied by 3D-FDTD simulation].

Science.gov (United States)

Li, Li-mei; Fang, Ping-ping; Yang, Zhi-lin; Huang, Wen-da; Wu, De-yin; Ren, Bin; Tian, Zhong-qun

2009-05-01

By synthesizing Au nanoparticles with the controllable size from about 16 to 160 nm and measuring their SERS activity, the authors found that Au nanoparticles film with a size in the range of 120-135 nm showed the highest SERS activity with the 632.8 nm excitation, which is different from previous experimental results and theoretical predictions. The three dimensional finite difference time domain (3D-FDTD)method was employed to simulate the size dependent SERS activity. At the 632.8 nm excitation, the particles with a size of 110 nm shows the highest enhancement under coupling condition and presents an enhancement as high as 10(9) at the hot site. If the enhancement is averaged over the whole surface, the enhancement can still be as high as 10(7), in good agreement with our experimental data. For Au nanoparticles with a larger size such as 220 nm, the multipolar effect leads to the appearance of the second maximum enhancement with the increase in particles size. The averaged enhancement for the excitation line of 325 nm is only 10(2).

Near-real time 3D probabilistic earthquakes locations at Mt. Etna volcano

Science.gov (United States)

Barberi, G.; D'Agostino, M.; Mostaccio, A.; Patane', D.; Tuve', T.

2012-04-01

Automatic procedure for locating earthquake in quasi-real time must provide a good estimation of earthquakes location within a few seconds after the event is first detected and is strongly needed for seismic warning system. The reliability of an automatic location algorithm is influenced by several factors such as errors in picking seismic phases, network geometry, and velocity model uncertainties. On Mt. Etna, the seismic network is managed by INGV and the quasi-real time earthquakes locations are performed by using an automatic-picking algorithm based on short-term-average to long-term-average ratios (STA/LTA) calculated from an approximate squared envelope function of the seismogram, which furnish a list of P-wave arrival times, and the location algorithm Hypoellipse, with a 1D velocity model. The main purpose of this work is to investigate the performances of a different automatic procedure to improve the quasi-real time earthquakes locations. In fact, as the automatic data processing may be affected by outliers (wrong picks), the use of a traditional earthquake location techniques based on a least-square misfit function (L2-norm) often yield unstable and unreliable solutions. Moreover, on Mt. Etna, the 1D model is often unable to represent the complex structure of the volcano (in particular the strong lateral heterogeneities), whereas the increasing accuracy in the 3D velocity models at Mt. Etna during recent years allows their use today in routine earthquake locations. Therefore, we selected, as reference locations, all the events occurred on Mt. Etna in the last year (2011) which was automatically detected and located by means of the Hypoellipse code. By using this dataset (more than 300 events), we applied a nonlinear probabilistic earthquake location algorithm using the Equal Differential Time (EDT) likelihood function, (Font et al., 2004; Lomax, 2005) which is much more robust in the presence of outliers in the data. Successively, by using a probabilistic

Arena3D: visualizing time-driven phenotypic differences in biological systems

Directory of Open Access Journals (Sweden)

Secrier Maria

2012-03-01

Full Text Available Abstract Background Elucidating the genotype-phenotype connection is one of the big challenges of modern molecular biology. To fully understand this connection, it is necessary to consider the underlying networks and the time factor. In this context of data deluge and heterogeneous information, visualization plays an essential role in interpreting complex and dynamic topologies. Thus, software that is able to bring the network, phenotypic and temporal information together is needed. Arena3D has been previously introduced as a tool that facilitates link discovery between processes. It uses a layered display to separate different levels of information while emphasizing the connections between them. We present novel developments of the tool for the visualization and analysis of dynamic genotype-phenotype landscapes. Results Version 2.0 introduces novel features that allow handling time course data in a phenotypic context. Gene expression levels or other measures can be loaded and visualized at different time points and phenotypic comparison is facilitated through clustering and correlation display or highlighting of impacting changes through time. Similarity scoring allows the identification of global patterns in dynamic heterogeneous data. In this paper we demonstrate the utility of the tool on two distinct biological problems of different scales. First, we analyze a medium scale dataset that looks at perturbation effects of the pluripotency regulator Nanog in murine embryonic stem cells. Dynamic cluster analysis suggests alternative indirect links between Nanog and other proteins in the core stem cell network. Moreover, recurrent correlations from the epigenetic to the translational level are identified. Second, we investigate a large scale dataset consisting of genome-wide knockdown screens for human genes essential in the mitotic process. Here, a potential new role for the gene lsm14a in cytokinesis is suggested. We also show how phenotypic

On the small time asymptotics of 3D stochastic primitive equations

OpenAIRE

Dong, Zhao; Zhang, Rangrang

2017-01-01

In this paper, we establish a small time large deviation principle for the strong solution of 3D stochastic primitive equations driven by multiplicative noise. Both the small noise and the small, but highly nonlinear, unbounded nonlinear terms should be taken into consideration.

Microbiological Characteristic and Nutrition Quality of Goat Milk Kefir Based on Vitamin D3 Fortification Time

Science.gov (United States)

Fauziyyah, F.; Panunggal, B.; Afifah, D. N.; Rustanti, N.; Anjani, G.

2018-02-01

Goat milk kefir fortified with vitamin D3 is expected to benefit individual with insulin resistance. Different vitamin D3 fortification time allegedly effect microbiological characteristic and nutrition quality of goat milk kefir due to its microbial growth curve, thus this study aimed to analyze those parameters. This study was an experimental research. This study contains five treatments (vitamin D3 fortification at 0, 6, 12, 18, or 24 hours of fermentation) and a group of control. Total lactic acid bacteria, vitamin D3, protein level, fat contain, crude fiber, viscosity, and pH was analyzed by Total Plate Count, spectrophotometry, Bradford method, Babcock method, gravimetric analysis, Ostwald method, and pH meter respectively. Time of vitamin D3 fortification significantly effect vitamin D3 content (p=0,021), fat content (p=0,001), crude fiber (p=0,0001), viscosity (p=0,010), and total lactic acid bacteria (p=0,048). The highest vitamin D3 content was found on the group fortified at 6 hours of fermentation. All treatment groups has lower fat content and crude fiber content than control group. Total LAB in all group meet the Codex standard (≥ 107 CFU/ml). Control group and fortification group at 24 hours of fermentation have higher viscosity than other groups. There was no significant difference found in goat milk kefir protein level (p=0,262) and pH (p=0,056) despite the difference of fortification time. Vitamin D3 fortification time effect vitamin D3 content, fat content, crude fiber, viscosity, and total lactic acid bacteria of goat milk kefir, but did not effect protein content and pH of goat milk kefir.

V-Man Generation for 3-D Real Time Animation. Chapter 5

Science.gov (United States)

Nebel, Jean-Christophe; Sibiryakov, Alexander; Ju, Xiangyang

2007-01-01

The V-Man project has developed an intuitive authoring and intelligent system to create, animate, control and interact in real-time with a new generation of 3D virtual characters: The V-Men. It combines several innovative algorithms coming from Virtual Reality, Physical Simulation, Computer Vision, Robotics and Artificial Intelligence. Given a high-level task like "walk to that spot" or "get that object", a V-Man generates the complete animation required to accomplish the task. V-Men synthesise motion at runtime according to their environment, their task and their physical parameters, drawing upon its unique set of skills manufactured during the character creation. The key to the system is the automated creation of realistic V-Men, not requiring the expertise of an animator. It is based on real human data captured by 3D static and dynamic body scanners, which is then processed to generate firstly animatable body meshes, secondly 3D garments and finally skinned body meshes.

3D visualization reduces operating time when compared to high-definition 2D in laparoscopic liver resection: a case-matched study.

Science.gov (United States)

Velayutham, Vimalraj; Fuks, David; Nomi, Takeo; Kawaguchi, Yoshikuni; Gayet, Brice

2016-01-01

To evaluate the effect of three-dimensional (3D) visualization on operative performance during elective laparoscopic liver resection (LLR). Major limitations of conventional laparoscopy are lack of depth perception and tactile feedback. Introduction of robotic technology, which employs 3D imaging, has removed only one of these technical obstacles. Despite the significant advantages claimed, 3D systems have not been widely accepted. In this single institutional study, 20 patients undergoing LLR by high-definition 3D laparoscope between April 2014 and August 2014 were matched to a retrospective control group of patients who underwent LLR by two-dimensional (2D) laparoscope. The number of patients who underwent major liver resection was 5 (25%) in the 3D group and 10 (25%) in the 2D group. There was no significant difference in contralateral wedge resection or combined resections between the 3D and 2D groups. There was no difference in the proportion of patients undergoing previous abdominal surgery (70 vs. 77%, p = 0.523) or previous hepatectomy (20 vs. 27.5%, p = 0.75). The operative time was significantly shorter in the 3D group when compared to 2D (225 ± 109 vs. 284 ± 71 min, p = 0.03). There was no significant difference in blood loss in the 3D group when compared to 2D group (204 ± 226 in 3D vs. 252 ± 349 ml in 2D group, p = 0.291). The major complication rates were similar, 5% (1/20) and 7.5% (3/40), respectively, (p ≥ 0.99). 3D visualization may reduce the operating time compared to high-definition 2D. Further large studies, preferably prospective randomized control trials are required to confirm this.

Mining biological information from 3D short time-series gene expression data: the OPTricluster algorithm.

Science.gov (United States)

Tchagang, Alain B; Phan, Sieu; Famili, Fazel; Shearer, Heather; Fobert, Pierre; Huang, Yi; Zou, Jitao; Huang, Daiqing; Cutler, Adrian; Liu, Ziying; Pan, Youlian

2012-04-04

Nowadays, it is possible to collect expression levels of a set of genes from a set of biological samples during a series of time points. Such data have three dimensions: gene-sample-time (GST). Thus they are called 3D microarray gene expression data. To take advantage of the 3D data collected, and to fully understand the biological knowledge hidden in the GST data, novel subspace clustering algorithms have to be developed to effectively address the biological problem in the corresponding space. We developed a subspace clustering algorithm called Order Preserving Triclustering (OPTricluster), for 3D short time-series data mining. OPTricluster is able to identify 3D clusters with coherent evolution from a given 3D dataset using a combinatorial approach on the sample dimension, and the order preserving (OP) concept on the time dimension. The fusion of the two methodologies allows one to study similarities and differences between samples in terms of their temporal expression profile. OPTricluster has been successfully applied to four case studies: immune response in mice infected by malaria (Plasmodium chabaudi), systemic acquired resistance in Arabidopsis thaliana, similarities and differences between inner and outer cotyledon in Brassica napus during seed development, and to Brassica napus whole seed development. These studies showed that OPTricluster is robust to noise and is able to detect the similarities and differences between biological samples. Our analysis showed that OPTricluster generally outperforms other well known clustering algorithms such as the TRICLUSTER, gTRICLUSTER and K-means; it is robust to noise and can effectively mine the biological knowledge hidden in the 3D short time-series gene expression data.

3D Elevation Program—Virtual USA in 3D

Science.gov (United States)

Lukas, Vicki; Stoker, J.M.

2016-04-14

The U.S. Geological Survey (USGS) 3D Elevation Program (3DEP) uses a laser system called ‘lidar’ (light detection and ranging) to create a virtual reality map of the Nation that is very accurate. 3D maps have many uses with new uses being discovered all the time.  

Quasi 3D dosimetry (EPID, conventional 2D/3D detector matrices)

International Nuclear Information System (INIS)

Bäck, A

2015-01-01

Patient specific pretreatment measurement for IMRT and VMAT QA should preferably give information with a high resolution in 3D. The ability to distinguish complex treatment plans, i.e. treatment plans with a difference between measured and calculated dose distributions that exceeds a specified tolerance, puts high demands on the dosimetry system used for the pretreatment measurements and the results of the measurement evaluation needs a clinical interpretation. There are a number of commercial dosimetry systems designed for pretreatment IMRT QA measurements. 2D arrays such as MapCHECK ® (Sun Nuclear), MatriXX Evolution (IBA Dosimetry) and OCTAVIOUS ® 1500 (PTW), 3D phantoms such as OCTAVIUS ® 4D (PTW), ArcCHECK ® (Sun Nuclear) and Delta 4 (ScandiDos) and software for EPID dosimetry and 3D reconstruction of the dose in the patient geometry such as EPIDose TM (Sun Nuclear) and Dosimetry Check TM (Math Resolutions) are available. None of those dosimetry systems can measure the 3D dose distribution with a high resolution (full 3D dose distribution). Those systems can be called quasi 3D dosimetry systems. To be able to estimate the delivered dose in full 3D the user is dependent on a calculation algorithm in the software of the dosimetry system. All the vendors of the dosimetry systems mentioned above provide calculation algorithms to reconstruct a full 3D dose in the patient geometry. This enables analyzes of the difference between measured and calculated dose distributions in DVHs of the structures of clinical interest which facilitates the clinical interpretation and is a promising tool to be used for pretreatment IMRT QA measurements. However, independent validation studies on the accuracy of those algorithms are scarce. Pretreatment IMRT QA using the quasi 3D dosimetry systems mentioned above rely on both measurement uncertainty and accuracy of calculation algorithms. In this article, these quasi 3D dosimetry systems and their use in patient specific

YouDash3D: exploring stereoscopic 3D gaming for 3D movie theaters

Science.gov (United States)

Schild, Jonas; Seele, Sven; Masuch, Maic

2012-03-01

Along with the success of the digitally revived stereoscopic cinema, events beyond 3D movies become attractive for movie theater operators, i.e. interactive 3D games. In this paper, we present a case that explores possible challenges and solutions for interactive 3D games to be played by a movie theater audience. We analyze the setting and showcase current issues related to lighting and interaction. Our second focus is to provide gameplay mechanics that make special use of stereoscopy, especially depth-based game design. Based on these results, we present YouDash3D, a game prototype that explores public stereoscopic gameplay in a reduced kiosk setup. It features live 3D HD video stream of a professional stereo camera rig rendered in a real-time game scene. We use the effect to place the stereoscopic effigies of players into the digital game. The game showcases how stereoscopic vision can provide for a novel depth-based game mechanic. Projected trigger zones and distributed clusters of the audience video allow for easy adaptation to larger audiences and 3D movie theater gaming.

Biochemical characterization of a D-psicose 3-epimerase from Treponema primitia ZAS-1 and its application on enzymatic production of D-psicose.

Science.gov (United States)

Zhang, Wenli; Zhang, Tao; Jiang, Bo; Mu, Wanmeng

2016-01-15

The rare sugar D-psicose is a hexoketose monosaccharide and a C-3 epimer of D-fructose. D-Psicose is a novel functional sweetener with 70% of the sweetness but only 0.3% of the energy content of sucrose. Generally, the industrial production of D-psicose involves a bioconversion from D-fructose induced by ketose 3-epimerases. The D-psicose 3-epimerase (DPEase) gene from Treponema primitia ZAS-1 (Trpr-DPEase) was cloned and overexpressed in Escherichia coli BL21 (DE3). The recombinant enzyme was purified with a molecular mass of 33 kDa. Trpr-DPEase exhibited optimal activity at pH 8.0 and 70 °C and was sensitive to temperature, with relative thermal stability below 50 °C. It was strictly metal-dependent and displayed maximum catalytic activity with 450 µmol L(-1) Co(2+). The Km values of the enzyme for D-psicose and D-fructose were 209 and 279 mmol L(-1) respectively. The D-psicose/D-fructose equilibrium ratio of Trpr-DPEase was 28:72. A novel DPEase from T. primitia ZAS-1 was characterized that could catalyze the formation of D-psicose from D-fructose. D-Psicose was produced at a yield of 137.5 g L(-1) from 500 g L(-1) D-fructose, suggesting that Trpr-DPEase might be appropriate for the industrial production of D-psicose. © 2015 Society of Chemical Industry.

An active robot vision system for real-time 3-D structure recovery

Energy Technology Data Exchange (ETDEWEB)

Juvin, D. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. d`Electronique et d`Instrumentation Nucleaire; Boukir, S.; Chaumette, F.; Bouthemy, P. [Rennes-1 Univ., 35 (France)

1993-10-01

This paper presents an active approach for the task of computing the 3-D structure of a nuclear plant environment from an image sequence, more precisely the recovery of the 3-D structure of cylindrical objects. Active vision is considered by computing adequate camera motions using image-based control laws. This approach requires a real-time tracking of the limbs of the cylinders. Therefore, an original matching approach, which relies on an algorithm for determining moving edges, is proposed. This method is distinguished by its robustness and its easiness to implement. This method has been implemented on a parallel image processing board and real-time performance has been achieved. The whole scheme has been successfully validated in an experimental set-up.

An active robot vision system for real-time 3-D structure recovery

International Nuclear Information System (INIS)

Juvin, D.

1993-01-01

This paper presents an active approach for the task of computing the 3-D structure of a nuclear plant environment from an image sequence, more precisely the recovery of the 3-D structure of cylindrical objects. Active vision is considered by computing adequate camera motions using image-based control laws. This approach requires a real-time tracking of the limbs of the cylinders. Therefore, an original matching approach, which relies on an algorithm for determining moving edges, is proposed. This method is distinguished by its robustness and its easiness to implement. This method has been implemented on a parallel image processing board and real-time performance has been achieved. The whole scheme has been successfully validated in an experimental set-up

A Spatial Reference Grid for Real-Time Autonomous Underwater Modeling using 3-D Sonar

Energy Technology Data Exchange (ETDEWEB)

Auran, P.G.

1996-12-31

The offshore industry has recognized the need for intelligent underwater robotic vehicles. This doctoral thesis deals with autonomous underwater vehicles (AUVs) and concentrates on a data representation for real-time image formation and analysis. Its main objective is to develop a 3-D image representation suitable for autonomous perception objectives underwater, assuming active sonar as the main sensor for perception. The main contributions are: (1) A dynamical image representation for 3-D range data, (2) A basic electronic circuit and software system for 3-D sonar sampling and amplitude thresholding, (3) A model for target reliability, (4) An efficient connected components algorithm for 3-D segmentation, (5) A method for extracting general 3-D geometrical representations from segmented echo clusters, (6) Experimental results of planar and curved target modeling. 142 refs., 120 figs., 10 tabs.

S-25-hydroxyvitamin D and C3-epimers in pregnancy and infancy

DEFF Research Database (Denmark)

Dreier Mydtskov, Nanne; Lykkedegn, Sine; Fruekilde, Palle Back Nielsen

2017-01-01

BACKGROUND: Analysis of serum 25-hydroxyvitamin D (s-25(OH)D) may be complicated by the less active or in-active vitamin D metabolite C3-epi-25(OH)D3 (C3-epimer). We aimed to explore the relationship between s-C3-epimer and s-25(OH)D and other determinants and describe the longitudinal course of ...... correlated to s-25(OH)D, season, maternal vitamin D supplementation, maternal and infant age. The C3-epimer fraction was only of clinical importance in early infancy, where it could lead to misclassification of the vitamin D status.......BACKGROUND: Analysis of serum 25-hydroxyvitamin D (s-25(OH)D) may be complicated by the less active or in-active vitamin D metabolite C3-epi-25(OH)D3 (C3-epimer). We aimed to explore the relationship between s-C3-epimer and s-25(OH)D and other determinants and describe the longitudinal course...... correlated with s-25(OH)D (all time points, pvitamin D supplementation at some time points. The C3-epimer fraction fluctuated between adjacent time points. By cosinor analyses, a season-dependent sinusoidal pattern for s-25(OH)D and C3-epimer fraction...

A QCM-D study of the concentration- and time-dependent interactions of human LL37 with model mammalian lipid bilayers.

Science.gov (United States)

Lozeau, Lindsay D; Rolle, Marsha W; Camesano, Terri A

2018-07-01

The human antimicrobial peptide LL37 is promising as an alternative to antibiotics due to its biophysical interactions with charged bacterial lipids. However, its clinical potential is limited due to its interactions with zwitterionic mammalian lipids leading to cytotoxicity. Mechanistic insight into the LL37 interactions with mammalian lipids may enable rational design of less toxic LL37-based therapeutics. To this end, we studied concentration- and time-dependent interactions of LL37 with zwitterionic model phosphatidylcholine (PC) bilayers with quartz crystal microbalance with dissipation (QCM-D). LL37 mass adsorption and PC bilayer viscoelasticity changes were monitored by measuring changes in frequency (Δf) and dissipation (ΔD), respectively. The Voigt-Kelvin viscoelastic model was applied to Δf and ΔD to study changes in bilayer thickness and density with LL37 concentration. At low concentrations (0.10-1.00 μM), LL37 adsorbed onto bilayers in a concentration-dependent manner. Further analyses of Δf, ΔD and thickness revealed that peptide saturation on the bilayers was a threshold for interactions observed above 2.00 μM, interactions that were rapid, multi-step, and reached equilibrium in a concentration- and time-dependent manner. Based on these data, we proposed a model of stable transmembrane pore formation at 2.00-10.0 μM, or transition from a primarily lipid to a primarily protein film with a transmembrane pore formation intermediate state at concentrations of LL37 > 10 μM. The concentration-dependent interactions between LL37 and PC bilayers correlated with the observed concentration-dependent biological activities of LL37 (antimicrobial, immunomodulatory and non-cytotoxic at 0.1-1.0 μM, hemolytic and some cytotoxicity at 2.0-13 μM and cytotoxic at >13 μM). Copyright © 2018 Elsevier B.V. All rights reserved.

Measurement of time-dependent $CP$-violation observables in $B_s^0 \\to D_s^\\mp K^\\pm$

CERN Document Server

The LHCb Collaboration

2012-01-01

We report the first measurement of the time-dependent $CP$-violation observables in $B_s^0 \\to D_s^\\mp K^\\pm$ decays. We use a dataset corresponding to 1.0 fb$^{-1}$ of $pp$ collisions recorded with the LHCb detector at $\\sqrt{s} = 7$ TeV in 2011. We find the $CP$-violating observables to be $C = 1.01 \\pm 0.50 \\pm 0.23$, $S_f = -1.25 \\pm 0.56 \\pm 0.24$, $S_{\\bar{f}} = 0.08 \\pm 0.68 \\pm 0.28$, $D_f = -1.33 \\pm 0.60 \\pm 0.26$, $D_{\\bar{f}} = -0.81 \\pm 0.56 \\pm 0.26$, where the first uncertainties are statistical and the second uncertainties are systematic.

Note: Time-gated 3D single quantum dot tracking with simultaneous spinning disk imaging

International Nuclear Information System (INIS)

DeVore, M. S.; Stich, D. G.; Keller, A. M.; Phipps, M. E.; Hollingsworth, J. A.; Goodwin, P. M.; Werner, J. H.; Cleyrat, C.; Lidke, D. S.; Wilson, B. S.

2015-01-01

We describe recent upgrades to a 3D tracking microscope to include simultaneous Nipkow spinning disk imaging and time-gated single-particle tracking (SPT). Simultaneous 3D molecular tracking and spinning disk imaging enable the visualization of cellular structures and proteins around a given fluorescently labeled target molecule. The addition of photon time-gating to the SPT hardware improves signal to noise by discriminating against Raman scattering and short-lived fluorescence. In contrast to camera-based SPT, single-photon arrival times are recorded, enabling time-resolved spectroscopy (e.g., measurement of fluorescence lifetimes and photon correlations) to be performed during single molecule/particle tracking experiments

Note: Time-gated 3D single quantum dot tracking with simultaneous spinning disk imaging

Energy Technology Data Exchange (ETDEWEB)

DeVore, M. S.; Stich, D. G.; Keller, A. M.; Phipps, M. E.; Hollingsworth, J. A.; Goodwin, P. M.; Werner, J. H., E-mail: jwerner@lanl.gov [Center for Integrated Nanotechnologies, Los Alamos National Laboratory, Mail Stop G755, Los Alamos, New Mexico 87545 (United States); Cleyrat, C.; Lidke, D. S.; Wilson, B. S. [Department of Pathology and Cancer Research and Treatment Center, University of New Mexico, Albuquerque, New Mexico 87131 (United States)

2015-12-15

We describe recent upgrades to a 3D tracking microscope to include simultaneous Nipkow spinning disk imaging and time-gated single-particle tracking (SPT). Simultaneous 3D molecular tracking and spinning disk imaging enable the visualization of cellular structures and proteins around a given fluorescently labeled target molecule. The addition of photon time-gating to the SPT hardware improves signal to noise by discriminating against Raman scattering and short-lived fluorescence. In contrast to camera-based SPT, single-photon arrival times are recorded, enabling time-resolved spectroscopy (e.g., measurement of fluorescence lifetimes and photon correlations) to be performed during single molecule/particle tracking experiments.

Analysis of Time-Dependent Tritium Breeding Capability of Water Cooled Ceramic Breeder Blanket for CFETR

Science.gov (United States)

Gao, Fangfang; Zhang, Xiaokang; Pu, Yong; Zhu, Qingjun; Liu, Songlin

2016-08-01

Attaining tritium self-sufficiency is an important mission for the Chinese Fusion Engineering Testing Reactor (CFETR) operating on a Deuterium-Tritium (D-T) fuel cycle. It is necessary to study the tritium breeding ratio (TBR) and breeding tritium inventory variation with operation time so as to provide an accurate data for dynamic modeling and analysis of the tritium fuel cycle. A water cooled ceramic breeder (WCCB) blanket is one candidate of blanket concepts for the CFETR. Based on the detailed 3D neutronics model of CFETR with the WCCB blanket, the time-dependent TBR and tritium surplus were evaluated by a coupling calculation of the Monte Carlo N-Particle Transport Code (MCNP) and the fusion activation code FISPACT-2007. The results indicated that the TBR and tritium surplus of the WCCB blanket were a function of operation time and fusion power due to the Li consumption in breeder and material activation. In addition, by comparison with the results calculated by using the 3D neutronics model and employing the transfer factor constant from 1D to 3D, it is noted that 1D analysis leads to an over-estimation for the time-dependent tritium breeding capability when fusion power is larger than 1000 MW. supported by the National Magnetic Confinement Fusion Science Program of China (Nos. 2013GB108004, 2015GB108002, and 2014GB119000), and by National Natural Science Foundation of China (No. 11175207)

Vitamin D3 and 25-hydroxyvitamin D3 in pork and their relationship to vitamin D status in pigs

DEFF Research Database (Denmark)

Burild, Anders; Lauridsen, Charlotte; Faqir, Nasrin

2016-01-01

The content of vitamin D in pork produced in conventional systems depends on the vitamin D concentration in the pig feed. Both vitamin D3 and 25-hydroxyvitamin D3 (25(OH)D3) are essential sources of dietary vitamin D; however, bioavailability assessed by serum 25(OH)D3 concentration is reported...... of vitamin D3 and 25(OH)D3 in the pig feed for 49 d before slaughter. Concurrently, the 25(OH)D3 level in serum was investigated as a biomarker to assess the content of vitamin D3 and 25(OH)D3 in pig tissues. Adipose tissue, white and red muscle, the liver and serum were sampled from pigs fed feed containing...... either vitamin D3 or 25(OH)D3 at 5, 20, 35 or 50 µg/kg feed for 7 weeks before slaughter. The tissue 25(OH)D3 level was significantly higher in the pigs fed 25(OH)D3 compared with those fed vitamin D3, while the tissue vitamin D3 level was higher in the pigs fed vitamin D3 compared with those fed 25(OH...

tomo3d: a new 3-D joint refraction and reflection travel-time tomography code for active-source seismic data

Science.gov (United States)

Meléndez, A.; Korenaga, J.; Sallares, V.; Ranero, C. R.

2012-12-01

We present the development state of tomo3d, a code for three-dimensional refraction and reflection travel-time tomography of wide-angle seismic data based on the previous two-dimensional version of the code, tomo2d. The core of both forward and inverse problems is inherited from the 2-D version. The ray tracing is performed by a hybrid method combining the graph and bending methods. The graph method finds an ordered array of discrete model nodes, which satisfies Fermat's principle, that is, whose corresponding travel time is a global minimum within the space of discrete nodal connections. The bending method is then applied to produce a more accurate ray path by using the nodes as support points for an interpolation with beta-splines. Travel time tomography is formulated as an iterative linearized inversion, and each step is solved using an LSQR algorithm. In order to avoid the singularity of the sensitivity kernel and to reduce the instability of inversion, regularization parameters are introduced in the inversion in the form of smoothing and damping constraints. Velocity models are built as 3-D meshes, and velocity values at intermediate locations are obtained by trilinear interpolation within the corresponding pseudo-cubic cell. Meshes are sheared to account for topographic relief. A floating reflector is represented by a 2-D grid, and depths at intermediate locations are calculated by bilinear interpolation within the corresponding square cell. The trade-off between the resolution of the final model and the associated computational cost is controlled by the relation between the selected forward star for the graph method (i.e. the number of nodes that each node considers as its neighbors) and the refinement of the velocity mesh. Including reflected phases is advantageous because it provides a better coverage and allows us to define the geometry of those geological interfaces with velocity contrasts sharp enough to be observed on record sections. The code also

Study of plasma meniscus formation and beam halo in negative ion source using the 3D3VPIC model

International Nuclear Information System (INIS)

Nishioka, S.; Goto, I.; Hatayama, A.; Miyamoto, K.; Fukano, A.

2015-01-01

In this paper, the effect of the electron confinement time on the plasma meniscus and the fraction of the beam halo is investigated by 3D3V-PIC (three dimension in real space and three dimension in velocity space) (Particle in Cell) simulation in the extraction region of negative ion source. The electron confinement time depends on the characteristic time of electron escape along the magnetic field as well as the characteristic time of diffusion across the magnetic field. Our 3D3V-PIC results support the previous result by 2D3V-PIC results i.e., it is confirmed that the penetration of the plasma meniscus becomes deep into the source plasma region when the effective confinement time is short

Study of plasma meniscus formation and beam halo in negative ion source using the 3D3VPIC model

Energy Technology Data Exchange (ETDEWEB)

Nishioka, S.; Goto, I.; Hatayama, A. [Graduate school of Science and Technology, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522 (Japan); Miyamoto, K. [Naruto University of Education, 748 Nakashima, Takashima, Naruto-cho, Naruto-shi, Tokushima 772-8502 (Japan); Fukano, A. [Tokyo Metropolitan Collage of Industrial Technology, Higashioi, Shinagawa, Tokyo 140-0011 (Japan)

2015-04-08

In this paper, the effect of the electron confinement time on the plasma meniscus and the fraction of the beam halo is investigated by 3D3V-PIC (three dimension in real space and three dimension in velocity space) (Particle in Cell) simulation in the extraction region of negative ion source. The electron confinement time depends on the characteristic time of electron escape along the magnetic field as well as the characteristic time of diffusion across the magnetic field. Our 3D3V-PIC results support the previous result by 2D3V-PIC results i.e., it is confirmed that the penetration of the plasma meniscus becomes deep into the source plasma region when the effective confinement time is short.

Methodology for Time-Domain Estimation of Storm-Time Electric Fields Using the 3D Earth Impedance

Science.gov (United States)

Kelbert, A.; Balch, C. C.; Pulkkinen, A. A.; Egbert, G. D.; Love, J. J.; Rigler, E. J.; Fujii, I.

2016-12-01

Magnetic storms can induce geoelectric fields in the Earth's electrically conducting interior, interfering with the operations of electric-power grid industry. The ability to estimate these electric fields at Earth's surface in close to real-time and to provide local short-term predictions would improve the ability of the industry to protect their operations. At any given time, the electric field at the Earth's surface is a function of the time-variant magnetic activity (driven by the solar wind), and the local electrical conductivity structure of the Earth's crust and mantle. For this reason, implementation of an operational electric field estimation service requires an interdisciplinary, collaborative effort between space science, real-time space weather operations, and solid Earth geophysics. We highlight in this talk an ongoing collaboration between USGS, NOAA, NASA, Oregon State University, and the Japan Meteorological Agency, to develop algorithms that can be used for scenario analyses and which might be implemented in a real-time, operational setting. We discuss the development of a time domain algorithm that employs discrete time domain representation of the impedance tensor for a realistic 3D Earth, known as the discrete time impulse response (DTIR), convolved with the local magnetic field time series, to estimate the local electric field disturbances. The algorithm is validated against measured storm-time electric field data collected in the United States and Japan. We also discuss our plans for operational real-time electric field estimation using 3D Earth impedances.

4-D ICE: A 2-D Array Transducer With Integrated ASIC in a 10-Fr Catheter for Real-Time 3-D Intracardiac Echocardiography.

Science.gov (United States)

Wildes, Douglas; Lee, Warren; Haider, Bruno; Cogan, Scott; Sundaresan, Krishnakumar; Mills, David M; Yetter, Christopher; Hart, Patrick H; Haun, Christopher R; Concepcion, Mikael; Kirkhorn, Johan; Bitoun, Marc

2016-12-01

We developed a 2.5 ×6.6 mm 2 2 -D array transducer with integrated transmit/receive application-specific integrated circuit (ASIC) for real-time 3-D intracardiac echocardiography (4-D ICE) applications. The ASIC and transducer design were optimized so that the high-voltage transmit, low-voltage time-gain control and preamp, subaperture beamformer, and digital control circuits for each transducer element all fit within the 0.019-mm 2 area of the element. The transducer assembly was deployed in a 10-Fr (3.3-mm diameter) catheter, integrated with a GE Vivid E9 ultrasound imaging system, and evaluated in three preclinical studies. The 2-D image quality and imaging modes were comparable to commercial 2-D ICE catheters. The 4-D field of view was at least 90 ° ×60 ° ×8 cm and could be imaged at 30 vol/s, sufficient to visualize cardiac anatomy and other diagnostic and therapy catheters. 4-D ICE should significantly reduce X-ray fluoroscopy use and dose during electrophysiology ablation procedures. 4-D ICE may be able to replace transesophageal echocardiography (TEE), and the associated risks and costs of general anesthesia, for guidance of some structural heart procedures.

3D Volume Rendering and 3D Printing (Additive Manufacturing).

Science.gov (United States)

Katkar, Rujuta A; Taft, Robert M; Grant, Gerald T

2018-07-01

Three-dimensional (3D) volume-rendered images allow 3D insight into the anatomy, facilitating surgical treatment planning and teaching. 3D printing, additive manufacturing, and rapid prototyping techniques are being used with satisfactory accuracy, mostly for diagnosis and surgical planning, followed by direct manufacture of implantable devices. The major limitation is the time and money spent generating 3D objects. Printer type, material, and build thickness are known to influence the accuracy of printed models. In implant dentistry, the use of 3D-printed surgical guides is strongly recommended to facilitate planning and reduce risk of operative complications. Copyright © 2018 Elsevier Inc. All rights reserved.

DELTA 3D PRINTER

Directory of Open Access Journals (Sweden)

ȘOVĂILĂ Florin

2016-07-01

Full Text Available 3D printing is a very used process in industry, the generic name being “rapid prototyping”. The essential advantage of a 3D printer is that it allows the designers to produce a prototype in a very short time, which is tested and quickly remodeled, considerably reducing the required time to get from the prototype phase to the final product. At the same time, through this technique we can achieve components with very precise forms, complex pieces that, through classical methods, could have been accomplished only in a large amount of time. In this paper, there are presented the stages of a 3D model execution, also the physical achievement after of a Delta 3D printer after the model.

Effect of scopolamine on central DAT and D2 receptor in morphine dependent rats

International Nuclear Information System (INIS)

Lin Yansong; Wang Shizhen; Ding Shiyu; Chen Zhenping; Zhou Xiang; Fang Ping; Wang Bocheng

2004-01-01

Objective: To investigate the effect of scopolamine (Sco) on central dopamine transporter (DAT) and D 2 receptor in morphine (Mor) dependent rats. Methods: Chronic Mor exposure was induced by repeated Mor (20 mg·kg -1 ·d -1 , i.p.) treatment for 8 d. Conditioned place preference test was used to evaluate the drug seeking behavior. Biodistribution of the imaging agents 125 I-2β-carbomethoxy-3β-(4-iodophenyl) tropane (β-CIT) and 125 I-3-iodo-2-hydroxy-6-methoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl] benzamide (IBZM) were used to evaluate the central DAT and D 2 receptor during chronic Mor exposure. Results: For the Mor plus pretreating with Sco (Mor+Sco) rats, the time for the rats entering C2 from C1 was (1.72 ± 0.69) min in the first day, with little difference from the control and Mor group (P>0.05), and (1.12 ± 0.33) min for the 8th day, still longer than that of the Mor group (t=5.171, P 125 I-β- CIT %ID/g in striatum (ST) and nucleus accumbens (NAC) for Mor + Sco group were 3.307 ± 0.189 and 1.577 ± 0.401 respectively, higher than those of the control group (2.431 ± 0.104, 1.441 ± 0.043, t was 4.151 and 5.416 respectively, P 125 I-IBZM %ID/g in ST, NAC, hippocampus (HIP) and frontal cortex (FC) for Mor + Sco group were 0.589 ± 0.081, 0.683 ± 0.046, 0.175 ± 0.039 and 0.257 ± 0.034 lower than that of the control rats (0.735 ± 0.096, 0.709 ± 0.098, 0.281 ± 0.038, 0.289 ± 0.020, t was 7.841, 6.170, 5.446 and 4.337 respectively, P 2 receptor induced by Mor to some extent

Carbon Abundances In The Light Of 3D Model Stellar Atmospheres

DEFF Research Database (Denmark)

Collet, Remo

Classical spectroscopic analyses of late-type stars generally rely on the interpretation of observations with the use of stationary, one-dimensional (1D), hydrostatic model stellar atmospheres. In recent years, however, there has been significant development in the field of three-dimensional (3D......) hydrodynamic modelling of stellar atmospheres and stellar spectra. In this contribution, I describe quantitatively the impact of realistic, time-dependent, 3D hydrodynamic model atmospheres on the spectroscopic determination of carbon abundances from CH molecular lines for stars with a wide range of stellar...... parameters and compositions. I show that the differences with respect to classical analyses based on 1D models can be significant in very metal-poor stars and of the order of -0.5 to -1 dex in terms of logarithmic abundances of these important elements. I also examine the dependence of differential 3D-1D...

2H(d,p)3H and 2H(d,n)3He reactions at sub-coulomb energies

International Nuclear Information System (INIS)

Tumino, A.; Spitaleri, C.; Mukhamedzhanov, A. M.; Typel, S.; Spartá, R.; Aliotta, M.; Kroha, V.; Hons, Z.; La Cognata, M.; Lamia, L.; Pizzone, R. G.; Mrazek, J.; Pizzone, R. G.; Rapisarda, G. G.; Romano, S.; Sergi, M. L.

2012-01-01

The 2 H( 3 He,p 3 H) 1 H and 2 H( 3 He,n 3 He) 1 H processes have been measured in quasi free kinematics to investigate for the first time the 2 H(d,p) 3 H and 2 H(d,n) 3 He reactions by means of the Trojan Horse Method. The 3 He+d experiment was performed at 18 MeV, corresponding the a d-d energy range from 1.5 MeV down to 2 keV. This range overlaps with the relevant region for Standard Big Bang Nucleosynthesis as well as with the thermal energies of future fusion reactors and deuterium burning in the Pre Main Sequence phase of stellar evolution. This is the first pioneering experiment in quasi free regime where the charged spectator is detected. Both the energy dependence and the absolute value of the bare nucleus S(E) factors have been extracted for the first time. They deviate by more than 15% from available direct data with new S(0) values of 57.4±1.8 MeVb for 3 H+p and 60.1±1.9 MeVb for 3 He+n. None of the existing fitting curves is able to provide the correct slope of the new data in the full range, thus calling for a revision of the theoretical description. This has consequences in the calculation of the reaction rates with more than a 25% increase at the temperatures of future fusion reactors.

Fortran programs for the time-dependent Gross-Pitaevskii equation in a fully anisotropic trap

Science.gov (United States)

Muruganandam, P.; Adhikari, S. K.

2009-10-01

Here we develop simple numerical algorithms for both stationary and non-stationary solutions of the time-dependent Gross-Pitaevskii (GP) equation describing the properties of Bose-Einstein condensates at ultra low temperatures. In particular, we consider algorithms involving real- and imaginary-time propagation based on a split-step Crank-Nicolson method. In a one-space-variable form of the GP equation we consider the one-dimensional, two-dimensional circularly-symmetric, and the three-dimensional spherically-symmetric harmonic-oscillator traps. In the two-space-variable form we consider the GP equation in two-dimensional anisotropic and three-dimensional axially-symmetric traps. The fully-anisotropic three-dimensional GP equation is also considered. Numerical results for the chemical potential and root-mean-square size of stationary states are reported using imaginary-time propagation programs for all the cases and compared with previously obtained results. Also presented are numerical results of non-stationary oscillation for different trap symmetries using real-time propagation programs. A set of convenient working codes developed in Fortran 77 are also provided for all these cases (twelve programs in all). In the case of two or three space variables, Fortran 90/95 versions provide some simplification over the Fortran 77 programs, and these programs are also included (six programs in all). Program summaryProgram title: (i) imagetime1d, (ii) imagetime2d, (iii) imagetime3d, (iv) imagetimecir, (v) imagetimesph, (vi) imagetimeaxial, (vii) realtime1d, (viii) realtime2d, (ix) realtime3d, (x) realtimecir, (xi) realtimesph, (xii) realtimeaxial Catalogue identifier: AEDU_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEDU_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data

Time resolved spectroscopic investigation of SiD2 + D2: kinetic study

Science.gov (United States)

Al-Rubaiey, Najem A.; Walsh, Robin

2017-03-01

Silylenes (silanediyls) have made an important impact on organosilicon chemistry even if it is of more recent foundation than carbenes in organic chemistry and much less complete. These species are highly reactive intermediates. They play a central role in the chemical vapour deposition (CVD) of various silicon-containing thin films which have a technological importance in microelectronics as well as in the dry etching processes of silicon wafers. Spectroscopic methods have been developed to observe these species, a necessary pre-requisite to their direct monitoring. In this work, deuterated phenylsilane precursor, PhSiD3 was chosen for SiD2 because its analogue phenylsilane, PhSiH3 proved to be a good precursor for SiH2 and the high quality decay signals observed revealed that SiD2 be readily detected from PhSiD3 and that if other decomposition pathways (e.g. PhSiD + D2) are occurring, they do not effect measurements of the rate constants for SiD2. The absorption spectrum of SiD2 formed from the flash photolysis of a mixture of PhSiD3 and SF6 at 193nm were found in the region 17384-17391 cm-1 with strong band at 17387.07 cm-1. This single rotational line of pQ1 was chosen to monitor SiD2 removal. Time-resolved studies of SiD2 have been carried out to obtain rate constants for its bimolecular reactions with D2. The reactions were studied over the pressure range 5-100 Torr (in SF6 bath gas) at four temperatures in the range 298-498K. Single decay from 10 photolysis laser shots were averaged and found to give reasonable first-order kinetics fits. Second order kinetics were obtained by pressure dependence of the pseudo first order decay constants and substance D2 pressures within experimental error. The reaction was found to be weakly pressure dependent at all temperatures, consistent with a third-body mediated association process. In addition, SiH2+ H2 reaction is approximately ca. 60% faster than SiD2+D2 reaction. Theoretical extrapolations (using Lindemann

Time resolved spectroscopic investigation of SiD2 + D2: kinetic study

Directory of Open Access Journals (Sweden)

Al-Rubaiey Najem A.

2017-01-01

Full Text Available Silylenes (silanediyls have made an important impact on organosilicon chemistry even if it is of more recent foundation than carbenes in organic chemistry and much less complete. These species are highly reactive intermediates. They play a central role in the chemical vapour deposition (CVD of various silicon-containing thin films which have a technological importance in microelectronics as well as in the dry etching processes of silicon wafers. Spectroscopic methods have been developed to observe these species, a necessary pre-requisite to their direct monitoring. In this work, deuterated phenylsilane precursor, PhSiD3 was chosen for SiD2 because its analogue phenylsilane, PhSiH3 proved to be a good precursor for SiH2 and the high quality decay signals observed revealed that SiD2 be readily detected from PhSiD3 and that if other decomposition pathways (e.g. PhSiD + D2 are occurring, they do not effect measurements of the rate constants for SiD2. The absorption spectrum of SiD2 formed from the flash photolysis of a mixture of PhSiD3 and SF6 at 193nm were found in the region 17384-17391 cm-1 with strong band at 17387.07 cm-1. This single rotational line of pQ1 was chosen to monitor SiD2 removal. Time-resolved studies of SiD2 have been carried out to obtain rate constants for its bimolecular reactions with D2. The reactions were studied over the pressure range 5-100 Torr (in SF6 bath gas at four temperatures in the range 298-498K. Single decay from 10 photolysis laser shots were averaged and found to give reasonable first-order kinetics fits. Second order kinetics were obtained by pressure dependence of the pseudo first order decay constants and substance D2 pressures within experimental error. The reaction was found to be weakly pressure dependent at all temperatures, consistent with a third-body mediated association process. In addition, SiH2+ H2 reaction is approximately ca. 60% faster than SiD2+D2 reaction. Theoretical extrapolations (using

Intermediate view reconstruction using adaptive disparity search algorithm for real-time 3D processing

Science.gov (United States)

Bae, Kyung-hoon; Park, Changhan; Kim, Eun-soo

2008-03-01

In this paper, intermediate view reconstruction (IVR) using adaptive disparity search algorithm (ASDA) is for realtime 3-dimensional (3D) processing proposed. The proposed algorithm can reduce processing time of disparity estimation by selecting adaptive disparity search range. Also, the proposed algorithm can increase the quality of the 3D imaging. That is, by adaptively predicting the mutual correlation between stereo images pair using the proposed algorithm, the bandwidth of stereo input images pair can be compressed to the level of a conventional 2D image and a predicted image also can be effectively reconstructed using a reference image and disparity vectors. From some experiments, stereo sequences of 'Pot Plant' and 'IVO', it is shown that the proposed algorithm improves the PSNRs of a reconstructed image to about 4.8 dB by comparing with that of conventional algorithms, and reduces the Synthesizing time of a reconstructed image to about 7.02 sec by comparing with that of conventional algorithms.

A fast time-difference inverse solver for 3D EIT with application to lung imaging.

Science.gov (United States)

Javaherian, Ashkan; Soleimani, Manuchehr; Moeller, Knut

2016-08-01

A class of sparse optimization techniques that require solely matrix-vector products, rather than an explicit access to the forward matrix and its transpose, has been paid much attention in the recent decade for dealing with large-scale inverse problems. This study tailors application of the so-called Gradient Projection for Sparse Reconstruction (GPSR) to large-scale time-difference three-dimensional electrical impedance tomography (3D EIT). 3D EIT typically suffers from the need for a large number of voxels to cover the whole domain, so its application to real-time imaging, for example monitoring of lung function, remains scarce since the large number of degrees of freedom of the problem extremely increases storage space and reconstruction time. This study shows the great potential of the GPSR for large-size time-difference 3D EIT. Further studies are needed to improve its accuracy for imaging small-size anomalies.

Dependence of the Peak Fluxes of Solar Energetic Particles on CME 3D Parameters from STEREO and SOHO

International Nuclear Information System (INIS)

Park, Jinhye; Moon, Y.-J.; Lee, Harim

2017-01-01

We investigate the relationships between the peak fluxes of 18 solar energetic particle (SEP) events and associated coronal mass ejection (CME) 3D parameters (speed, angular width, and separation angle) obtained from SOHO , and STEREO-A / B for the period from 2010 August to 2013 June. We apply the STEREO CME Analysis Tool (StereoCAT) to the SEP-associated CMEs to obtain 3D speeds and 3D angular widths. The separation angles are determined as the longitudinal angles between flaring regions and magnetic footpoints of the spacecraft, which are calculated by the assumption of a Parker spiral field. The main results are as follows. (1) We find that the dependence of the SEP peak fluxes on CME 3D speed from multiple spacecraft is similar to that on CME 2D speed. (2) There is a positive correlation between SEP peak flux and 3D angular width from multiple spacecraft, which is much more evident than the relationship between SEP peak flux and 2D angular width. (3) There is a noticeable anti-correlation ( r = −0.62) between SEP peak flux and separation angle. (4) The multiple-regression method between SEP peak fluxes and CME 3D parameters shows that the longitudinal separation angle is the most important parameter, and the CME 3D speed is secondary on SEP peak flux.

Dependence of the Peak Fluxes of Solar Energetic Particles on CME 3D Parameters from STEREO and SOHO

Energy Technology Data Exchange (ETDEWEB)

Park, Jinhye; Moon, Y.-J. [Department of Astronomy and Space Science, Kyung Hee University, Yongin 17104 (Korea, Republic of); Lee, Harim, E-mail: jinhye@khu.ac.kr [School of Space Research, Kyung Hee University, Yongin 17104 (Korea, Republic of)

2017-07-20

We investigate the relationships between the peak fluxes of 18 solar energetic particle (SEP) events and associated coronal mass ejection (CME) 3D parameters (speed, angular width, and separation angle) obtained from SOHO , and STEREO-A / B for the period from 2010 August to 2013 June. We apply the STEREO CME Analysis Tool (StereoCAT) to the SEP-associated CMEs to obtain 3D speeds and 3D angular widths. The separation angles are determined as the longitudinal angles between flaring regions and magnetic footpoints of the spacecraft, which are calculated by the assumption of a Parker spiral field. The main results are as follows. (1) We find that the dependence of the SEP peak fluxes on CME 3D speed from multiple spacecraft is similar to that on CME 2D speed. (2) There is a positive correlation between SEP peak flux and 3D angular width from multiple spacecraft, which is much more evident than the relationship between SEP peak flux and 2D angular width. (3) There is a noticeable anti-correlation ( r = −0.62) between SEP peak flux and separation angle. (4) The multiple-regression method between SEP peak fluxes and CME 3D parameters shows that the longitudinal separation angle is the most important parameter, and the CME 3D speed is secondary on SEP peak flux.

47 CFR 3.72 - Grounds for further enforcement action.

Science.gov (United States)

2010-10-01

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Feasibility of the integration of CRONOS, a 3-D neutronics code, into real-time simulators

International Nuclear Information System (INIS)

Ragusa, J.C.

2001-01-01

In its effort to contribute to nuclear power plant safety, CEA proposes the integration of an engineering grade 3-D neutronics code into a real-time plant analyser. This paper describes the capabilities of the neutronics code CRONOS to achieve a fast running performance. First, we will present current core models in simulators and explain their drawbacks. Secondly, the mean features of CRONOS's spatial-kinetics methods will be reviewed. We will then present an optimum core representation with respect to mesh size, choice of finite elements (FE) basis and execution time, for accurate results as well as the multi 1-D thermal-hydraulics (T/H) model developed to take into account 3-D effects in updating the cross-sections. A Main Steam Line Break (MSLB) End-of-Life (EOL) Hot-Zero-Power (HZP) accident will be used as an example, before we conclude with the perspectives of integrating CRONOS's 3-D core model into real-time simulators. (author)

Feasibility of the integration of CRONOS, a 3-D neutronics code, into real-time simulators

Energy Technology Data Exchange (ETDEWEB)

Ragusa, J.C. [CEA Saclay, Dept. de Mecanique et de Technologie, 91 - Gif-sur-Yvette (France)

2001-07-01

In its effort to contribute to nuclear power plant safety, CEA proposes the integration of an engineering grade 3-D neutronics code into a real-time plant analyser. This paper describes the capabilities of the neutronics code CRONOS to achieve a fast running performance. First, we will present current core models in simulators and explain their drawbacks. Secondly, the mean features of CRONOS's spatial-kinetics methods will be reviewed. We will then present an optimum core representation with respect to mesh size, choice of finite elements (FE) basis and execution time, for accurate results as well as the multi 1-D thermal-hydraulics (T/H) model developed to take into account 3-D effects in updating the cross-sections. A Main Steam Line Break (MSLB) End-of-Life (EOL) Hot-Zero-Power (HZP) accident will be used as an example, before we conclude with the perspectives of integrating CRONOS's 3-D core model into real-time simulators. (author)

Generalized Hough transform based time invariant action recognition with 3D pose information

Science.gov (United States)

Muench, David; Huebner, Wolfgang; Arens, Michael

2014-10-01

Human action recognition has emerged as an important field in the computer vision community due to its large number of applications such as automatic video surveillance, content based video-search and human robot interaction. In order to cope with the challenges that this large variety of applications present, recent research has focused more on developing classifiers able to detect several actions in more natural and unconstrained video sequences. The invariance discrimination tradeoff in action recognition has been addressed by utilizing a Generalized Hough Transform. As a basis for action representation we transform 3D poses into a robust feature space, referred to as pose descriptors. For each action class a one-dimensional temporal voting space is constructed. Votes are generated from associating pose descriptors with their position in time relative to the end of an action sequence. Training data consists of manually segmented action sequences. In the detection phase valid human 3D poses are assumed as input, e.g. originating from 3D sensors or monocular pose reconstruction methods. The human 3D poses are normalized to gain view-independence and transformed into (i) relative limb-angle space to ensure independence of non-adjacent joints or (ii) geometric features. In (i) an action descriptor consists of the relative angles between limbs and their temporal derivatives. In (ii) the action descriptor consists of different geometric features. In order to circumvent the problem of time-warping we propose to use a codebook of prototypical 3D poses which is generated from sample sequences of 3D motion capture data. This idea is in accordance with the concept of equivalence classes in action space. Results of the codebook method are presented using the Kinect sensor and the CMU Motion Capture Database.

Strong decays of D{sub 3}{sup *}(2760), D{sub s3}{sup *}(2860), B{sub 3}{sup *}, and B{sub s3}{sup *}

Energy Technology Data Exchange (ETDEWEB)

Wang, Tianhong; Jiang, Yue; Wang, Guo-Li [Harbin Institute of Technology, Department of Physics, Harbin (China); Wang, Zhi-Hui [Beifang University of Nationalities, School of Electrical and Information Engineering, Yinchuan (China); Jiang, Libo [University of Pittsburgh, Department of Physics and Astronomy, Pittsburgh, PA (United States)

2017-01-15

In this paper, we study the OZI-allowed two-body strong decays of 3{sup -} heavy-light mesons. Experimentally the charmed D{sub 3}{sup *}(2760) and the charm-strange D{sub s3}{sup *}(2860) states with these quantum numbers have been discovered. For the bottomed B(5970) state, which was found by the CDF Collaboration recently, its quantum number has not been decided yet and we assume it is a 3{sup -} meson in this paper. The theoretical prediction for the strong decays of bottom-strange state B{sub s3}{sup *} is also given. The relativistic wave functions of 3{sup -} heavy mesons are constructed and their numerical values are obtained by solving the corresponding Bethe-Salpeter equation with instantaneous approximation. The transition matrix is calculated by using the PCAC and low energy theorem, following which the decay widths are obtained. For D{sub 3}{sup *}(2760) and D{sub s3}{sup *}(2860), the total strong decay widths are 72.6 and 47.6 MeV, respectively. For B{sub 3}{sup *} with M = 5978 MeV and B{sub s3}{sup *} with M = 6178 MeV, their strong decay widths are 22.9 and 40.8 MeV, respectively. (orig.)

Real-time 3D human capture system for mixed-reality art and entertainment.

Science.gov (United States)

Nguyen, Ta Huynh Duy; Qui, Tran Cong Thien; Xu, Ke; Cheok, Adrian David; Teo, Sze Lee; Zhou, ZhiYing; Mallawaarachchi, Asitha; Lee, Shang Ping; Liu, Wei; Teo, Hui Siang; Thang, Le Nam; Li, Yu; Kato, Hirokazu

2005-01-01

A real-time system for capturing humans in 3D and placing them into a mixed reality environment is presented in this paper. The subject is captured by nine cameras surrounding her. Looking through a head-mounted-display with a camera in front pointing at a marker, the user can see the 3D image of this subject overlaid onto a mixed reality scene. The 3D images of the subject viewed from this viewpoint are constructed using a robust and fast shape-from-silhouette algorithm. The paper also presents several techniques to produce good quality and speed up the whole system. The frame rate of our system is around 25 fps using only standard Intel processor-based personal computers. Besides a remote live 3D conferencing and collaborating system, we also describe an application of the system in art and entertainment, named Magic Land, which is a mixed reality environment where captured avatars of human and 3D computer generated virtual animations can form an interactive story and play with each other. This system demonstrates many technologies in human computer interaction: mixed reality, tangible interaction, and 3D communication. The result of the user study not only emphasizes the benefits, but also addresses some issues of these technologies.

Translation invariant time-dependent solutions to massive gravity II

Science.gov (United States)

Mourad, J.; Steer, D. A.

2014-06-01

This paper is a sequel to JCAP 12 (2013) 004 and is also devoted to translation-invariant solutions of ghost-free massive gravity in its moving frame formulation. Here we consider a mass term which is linear in the vielbein (corresponding to a β3 term in the 4D metric formulation) in addition to the cosmological constant. We determine explicitly the constraints, and from the initial value formulation show that the time-dependent solutions can have singularities at a finite time. Although the constraints give, as in the β1 case, the correct number of degrees of freedom for a massive spin two field, we show that the lapse function can change sign at a finite time causing a singular time evolution. This is very different to the β1 case where time evolution is always well defined. We conclude that the β3 mass term can be pathological and should be treated with care.

Audiovisual biofeedback improves image quality and reduces scan time for respiratory-gated 3D MRI

Science.gov (United States)

Lee, D.; Greer, P. B.; Arm, J.; Keall, P.; Kim, T.

2014-03-01

The purpose of this study was to test the hypothesis that audiovisual (AV) biofeedback can improve image quality and reduce scan time for respiratory-gated 3D thoracic MRI. For five healthy human subjects respiratory motion guidance in MR scans was provided using an AV biofeedback system, utilizing real-time respiratory motion signals. To investigate the improvement of respiratory-gated 3D MR images between free breathing (FB) and AV biofeedback (AV), each subject underwent two imaging sessions. Respiratory-related motion artifacts and imaging time were qualitatively evaluated in addition to the reproducibility of external (abdominal) motion. In the results, 3D MR images in AV biofeedback showed more anatomic information such as a clear distinction of diaphragm, lung lobes and sharper organ boundaries. The scan time was reduced from 401±215 s in FB to 334±94 s in AV (p-value 0.36). The root mean square variation of the displacement and period of the abdominal motion was reduced from 0.4±0.22 cm and 2.8±2.5 s in FB to 0.1±0.15 cm and 0.9±1.3 s in AV (p-value of displacement audiovisual biofeedback improves image quality and reduces scan time for respiratory-gated 3D MRI. These results suggest that AV biofeedback has the potential to be a useful motion management tool in medical imaging and radiation therapy procedures.

OECD/NEA benchmark for time-dependent neutron transport calculations without spatial homogenization

Energy Technology Data Exchange (ETDEWEB)

Hou, Jason, E-mail: jason.hou@ncsu.edu [Department of Nuclear Engineering, North Carolina State University, Raleigh, NC 27695 (United States); Ivanov, Kostadin N. [Department of Nuclear Engineering, North Carolina State University, Raleigh, NC 27695 (United States); Boyarinov, Victor F.; Fomichenko, Peter A. [National Research Centre “Kurchatov Institute”, Kurchatov Sq. 1, Moscow (Russian Federation)

2017-06-15

Highlights: • A time-dependent homogenization-free neutron transport benchmark was created. • The first phase, known as the kinetics phase, was described in this work. • Preliminary results for selected 2-D transient exercises were presented. - Abstract: A Nuclear Energy Agency (NEA), Organization for Economic Co-operation and Development (OECD) benchmark for the time-dependent neutron transport calculations without spatial homogenization has been established in order to facilitate the development and assessment of numerical methods for solving the space-time neutron kinetics equations. The benchmark has been named the OECD/NEA C5G7-TD benchmark, and later extended with three consecutive phases each corresponding to one modelling stage of the multi-physics transient analysis of the nuclear reactor core. This paper provides a detailed introduction of the benchmark specification of Phase I, known as the “kinetics phase”, including the geometry description, supporting neutron transport data, transient scenarios in both two-dimensional (2-D) and three-dimensional (3-D) configurations, as well as the expected output parameters from the participants. Also presented are the preliminary results for the initial state 2-D core and selected transient exercises that have been obtained using the Monte Carlo method and the Surface Harmonic Method (SHM), respectively.

Improving 3d Spatial Queries Search: Newfangled Technique of Space Filling Curves in 3d City Modeling

Science.gov (United States)

Uznir, U.; Anton, F.; Suhaibah, A.; Rahman, A. A.; Mioc, D.

2013-09-01

The advantages of three dimensional (3D) city models can be seen in various applications including photogrammetry, urban and regional planning, computer games, etc.. They expand the visualization and analysis capabilities of Geographic Information Systems on cities, and they can be developed using web standards. However, these 3D city models consume much more storage compared to two dimensional (2D) spatial data. They involve extra geometrical and topological information together with semantic data. Without a proper spatial data clustering method and its corresponding spatial data access method, retrieving portions of and especially searching these 3D city models, will not be done optimally. Even though current developments are based on an open data model allotted by the Open Geospatial Consortium (OGC) called CityGML, its XML-based structure makes it challenging to cluster the 3D urban objects. In this research, we propose an opponent data constellation technique of space-filling curves (3D Hilbert curves) for 3D city model data representation. Unlike previous methods, that try to project 3D or n-dimensional data down to 2D or 3D using Principal Component Analysis (PCA) or Hilbert mappings, in this research, we extend the Hilbert space-filling curve to one higher dimension for 3D city model data implementations. The query performance was tested using a CityGML dataset of 1,000 building blocks and the results are presented in this paper. The advantages of implementing space-filling curves in 3D city modeling will improve data retrieval time by means of optimized 3D adjacency, nearest neighbor information and 3D indexing. The Hilbert mapping, which maps a subinterval of the [0, 1] interval to the corresponding portion of the d-dimensional Hilbert's curve, preserves the Lebesgue measure and is Lipschitz continuous. Depending on the applications, several alternatives are possible in order to cluster spatial data together in the third dimension compared to its

PHISICS/RELAP5-3D Adaptive Time-Step Method Demonstrated for the HTTR LOFC#1 Simulation

Energy Technology Data Exchange (ETDEWEB)

Baker, Robin Ivey [Idaho National Lab. (INL), Idaho Falls, ID (United States); Balestra, Paolo [Univ. of Rome (Italy); Strydom, Gerhard [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2017-05-01

A collaborative effort between Japan Atomic Energy Agency (JAEA) and Idaho National Laboratory (INL) as part of the Civil Nuclear Energy Working Group is underway to model the high temperature engineering test reactor (HTTR) loss of forced cooling (LOFC) transient that was performed in December 2010. The coupled version of RELAP5-3D, a thermal fluids code, and PHISICS, a neutronics code, were used to model the transient. The focus of this report is to summarize the changes made to the PHISICS-RELAP5-3D code for implementing an adaptive time step methodology into the code for the first time, and to test it using the full HTTR PHISICS/RELAP5-3D model developed by JAEA and INL and the LOFC simulation. Various adaptive schemes are available based on flux or power convergence criteria that allow significantly larger time steps to be taken by the neutronics module. The report includes a description of the HTTR and the associated PHISICS/RELAP5-3D model test results as well as the University of Rome sub-contractor report documenting the adaptive time step theory and methodology implemented in PHISICS/RELAP5-3D. Two versions of the HTTR model were tested using 8 and 26 energy groups. It was found that most of the new adaptive methods lead to significant improvements in the LOFC simulation time required without significant accuracy penalties in the prediction of the fission power and the fuel temperature. In the best performing 8 group model scenarios, a LOFC simulation of 20 hours could be completed in real-time, or even less than real-time, compared with the previous version of the code that completed the same transient 3-8 times slower than real-time. A few of the user choice combinations between the methodologies available and the tolerance settings did however result in unacceptably high errors or insignificant gains in simulation time. The study is concluded with recommendations on which methods to use for this HTTR model. An important caveat is that these findings

Real time 3D structural and Doppler OCT imaging on graphics processing units

Science.gov (United States)

Sylwestrzak, Marcin; Szlag, Daniel; Szkulmowski, Maciej; Gorczyńska, Iwona; Bukowska, Danuta; Wojtkowski, Maciej; Targowski, Piotr

2013-03-01

In this report the application of graphics processing unit (GPU) programming for real-time 3D Fourier domain Optical Coherence Tomography (FdOCT) imaging with implementation of Doppler algorithms for visualization of the flows in capillary vessels is presented. Generally, the time of the data processing of the FdOCT data on the main processor of the computer (CPU) constitute a main limitation for real-time imaging. Employing additional algorithms, such as Doppler OCT analysis, makes this processing even more time consuming. Lately developed GPUs, which offers a very high computational power, give a solution to this problem. Taking advantages of them for massively parallel data processing, allow for real-time imaging in FdOCT. The presented software for structural and Doppler OCT allow for the whole processing with visualization of 2D data consisting of 2000 A-scans generated from 2048 pixels spectra with frame rate about 120 fps. The 3D imaging in the same mode of the volume data build of 220 × 100 A-scans is performed at a rate of about 8 frames per second. In this paper a software architecture, organization of the threads and optimization applied is shown. For illustration the screen shots recorded during real time imaging of the phantom (homogeneous water solution of Intralipid in glass capillary) and the human eye in-vivo is presented.

Exploration of dopamine transporter and D2 receptors in morphine dependent rats through 125I-β-CTT, 125I-IBZM cerebral autoradiography and the biodistribution study

International Nuclear Information System (INIS)

Lin Yansong; Fang Ping; Ding Shiyu; Chen Zhengping; Zhou Xiang; Hu Mingyang; Wang Bocheng; Zhang Manda; Wang Shizhen

2001-01-01

Objective: To explore the variation of cerebral dopamine (DA) transmitting system in morphine dependent (MD) rats using dopamine transporter (DAT) and D 2 receptors imaging agent. Methods: MD model rats were established by using a two-compartment (C1 and C2-morphine conditioned compartment) apparatus for assessing morphine conditioned place preferences in rats. 125 I-2β-carbomethoxy-3β-(4-iodophenyl) tropane ( 125 I-β-CIT) and 125 I-3-iodo-2-hydroxy-6-methoxy-N[(1-ethyl-2-pyrrolidinyl) methyl] benzamide ( 125 I-IBZM) cerebral DAT and D 2 receptor autoradiography and biodistribution study were used to evaluate the variation of DAT and D 2 receptors in morphine dependent rats. Results: The mean time of MD rats entering from C1 to C2 was (0.84 +- 0.50) min after 6 days' conditioned place preference training, shorter than that of the control group [(2.40 +- 1.10) min, P 125 I-β-CIT uptake ratio of striatum (ST)/cerebellum (CB) and nucleus acumens (NAC)/CB in MD group were 4.76 +- 0.92 and 2.72 +- 0.96, significantly lower than that of control group (5.92 +- 0.67 and 4.16 +- 0.56, P 125 I-IBZM uptake ratio in MD group were 4.11 +- 0.56 and 2.64 +- 0.25, lower than that in control group (5.43 +- 0.74 and 3.49 +- 0.65, P 125 I-β-CIT, 125 I-IBZM biodistribution study also showed that the DAT and D 2 binding sites were reduced in ST of MD group by (21.68 +- 11.11)% and (18.69 +- 9.97)% comparing to the controls, respectively. Conclusions: The DAT and D 2 receptors in both ST and NAC were all involved and reduced to some extent in morphine dependent model rats, the DAT and D 2 receptor imaging agent could reflect the variation of DAT and D 2 receptors, this would afford the theoretical basis for D 2 receptors and DAT imaging in study on preventing drug addiction and on its abstinence

A 72-dB-SNDR rail-to-rail successive approximation ADC using mismatch calibration techniques

International Nuclear Information System (INIS)

Liu Yan; Hua Siliang; Wang Donghui; Hou Chaohuan

2012-01-01

When the voltage of an analog input signal is equal to the supply voltage, it is difficult for a conventional successive approximation ADC to correctly convert the analog signal into digital signal. This paper introduces an improved successive approximation ADC, which can convert the rail-to-rail input range and reduce sampling time through a track-and-hold circuit. Comparator offset cancellation and capacitor self-calibration techniques are used in this ADC. Measurement results show that the peak SNDR of this ADC reaches 72 dB and the signal effective bandwidth is up to 1.25 MHz. It consumes 1 mW in the test, and the figure of merit is 123 fJ/conversion-step. (semiconductor integrated circuits)

With the advent of domestic 3-dimensional (3D) printers and their associated reduced cost, is it now time for every medical school to have their own 3D printer?

Science.gov (United States)

Balestrini, Christopher; Campo-Celaya, Tatiana

2016-01-01

Anatomy is the backbone of medical education and new techniques to improve learning are frequently explored. With the introduction of 3D printers specifically for the home market, the price of this technology has reached affordable levels. Using patient scan data, accurate 3D models can be printed that represent real human variation in anatomy to provide an innovative, inexpensive and valuable adjunct to anatomical teaching. Is it now time for every medical school to have their own 3D printer?

Time-dependent Hartree approximation and time-dependent harmonic oscillator model

International Nuclear Information System (INIS)

Blaizot, J.P.

1982-01-01

We present an analytically soluble model for studying nuclear collective motion within the framework of the time-dependent Hartree (TDH) approximation. The model reduces the TDH equations to the Schroedinger equation of a time-dependent harmonic oscillator. Using canonical transformations and coherent states we derive a few properties of the time-dependent harmonic oscillator which are relevant for applications. We analyse the role of the normal modes in the time evolution of a system governed by TDH equations. We show how these modes couple together due to the anharmonic terms generated by the non-linearity of the theory. (orig.)

3D MR cisternography to identify distal dural rings. Comparison of 3D-CISS and 3D-SPACE sequences

International Nuclear Information System (INIS)

Watanabe, Yoshiyuki; Makidono, Akari; Nakamura, Miho; Saida, Yukihisa

2011-01-01

The distal dural ring (DDR) is an anatomical landmark used to distinguish intra- and extradural aneurysms. We investigated identification of the DDR using 2 three-dimensional (3D) magnetic resonance (MR) cisternography sequences-3D constructive interference in steady state (CISS) and 3D sampling perfection with application optimized contrasts using different flip angle evolutions (SPACE)-at 3.0 tesla. Ten healthy adult volunteers underwent imaging with 3D-CISS, 3D-SPACE, and time-of-flight (TOF) MR angiography (TOF-MRA) sequences at 3.0T. We analyzed DDR identification and internal carotid artery (ICA) signal intensity and classified the shape of the carotid cave. We identified the DDR using both 3D-SPACE and 3D-CISS, with no significant difference between the sequences. Visualization of the outline of the ICA in the cavernous sinus (CS) was significantly clearer with 3D-SPACE than 3D-CISS. In the CS and petrous portions, signal intensity was lower with 3D-SPACE, and the flow void was poor with 3D-CISS in some subjects. We identified the DDR with both 3D-SPACE and 3D-CISS, but the superior contrast of the ICA in the CS using 3D-SPACE suggests the superiority of this sequence for evaluating the DDR. (author)

JHelioviewer. Time-dependent 3D visualisation of solar and heliospheric data

Science.gov (United States)

Müller, D.; Nicula, B.; Felix, S.; Verstringe, F.; Bourgoignie, B.; Csillaghy, A.; Berghmans, D.; Jiggens, P.; García-Ortiz, J. P.; Ireland, J.; Zahniy, S.; Fleck, B.

2017-09-01

Context. Solar observatories are providing the world-wide community with a wealth of data, covering wide time ranges (e.g. Solar and Heliospheric Observatory, SOHO), multiple viewpoints (Solar TErrestrial RElations Observatory, STEREO), and returning large amounts of data (Solar Dynamics Observatory, SDO). In particular, the large volume of SDO data presents challenges; the data are available only from a few repositories, and full-disk, full-cadence data for reasonable durations of scientific interest are difficult to download, due to their size and the download rates available to most users. From a scientist's perspective this poses three problems: accessing, browsing, and finding interesting data as efficiently as possible. Aims: To address these challenges, we have developed JHelioviewer, a visualisation tool for solar data based on the JPEG 2000 compression standard and part of the open source ESA/NASA Helioviewer Project. Since the first release of JHelioviewer in 2009, the scientific functionality of the software has been extended significantly, and the objective of this paper is to highlight these improvements. Methods: The JPEG 2000 standard offers useful new features that facilitate the dissemination and analysis of high-resolution image data and offers a solution to the challenge of efficiently browsing petabyte-scale image archives. The JHelioviewer software is open source, platform independent, and extendable via a plug-in architecture. Results: With JHelioviewer, users can visualise the Sun for any time period between September 1991 and today; they can perform basic image processing in real time, track features on the Sun, and interactively overlay magnetic field extrapolations. The software integrates solar event data and a timeline display. Once an interesting event has been identified, science quality data can be accessed for in-depth analysis. As a first step towards supporting science planning of the upcoming Solar Orbiter mission, JHelioviewer

Hα Equivalent Widths from the 3D-HST survey: evolution with redshift and dependence on stellar mass†

Science.gov (United States)

Fumagalli, Mattia; Patel, Shannon G.; Franx, Marijn; Brammer, Gabriel; van Dokkum, Pieter; da Cunha, Elisabete; Kriek, Mariska; Lundgren, Britt; Momcheva, Ivelina; Rix, Hans-Walter; Schmidt, Kasper B.; Skelton, Rosalind E.; Whitaker, Katherine E.; Labbe, Ivo; Nelson, Erica

2013-07-01

We investigate the evolution of the Hα equivalent width, EW(Hα), with redshift and its dependence on stellar mass, using the first data from the 3D-HST survey, a large spectroscopic Treasury program with the HST-WFC3. Combining our Hα measurements of 854 galaxies at 0.8dependence. Qualitatively, this measurement is a model-independent confirmation of the evolution of star forming galaxies with redshift. A quantitative conversion of EW(Hα) to sSFR (specific star-formation rate) is model dependent, because of differential reddening corrections between the continuum and the Balmer lines. The observed EW(Hα) can be reproduced with the characteristic evolutionary history for galaxies, whose star formation rises with cosmic time to z ~ 2.5 and then decreases to z = 0. This implies that EW(Hα) rises to 400 Å at z = 8. The sSFR evolves faster than EW(Hα), as the mass-to-light ratio also evolves with redshift. We find that the sSFR evolves as (1+z)3.2, nearly independent of mass, consistent with previous reddening insensitive estimates. We confirm previous results that the observed slope of the sSFR-z relation is steeper than the one predicted by models, but models and observations agree in finding little mass dependence.

Determination of the 3d34d and 3d35s configurations of Fe V

International Nuclear Information System (INIS)

Azarov, V.I.

2001-01-01

The analysis of the spectrum of four times ionized iron, Fe V, has led to the determination of the 3d 3 4d and 3d 3 5s configurations. From 975 classified lines in the region 645-1190 A we have established 123 of 168 theoretically possible 3d 3 4d levels and 26 of 38 possible 3d 3 5s levels. The estimated accuracy of values of energy levels of these two configurations is about 0.7 cm -1 and 1.0 cm -1 , respectively. The level structure of the system of the 3d 4 , 3d 3 4s, 3d 3 4d and 3d 3 5s configurations has been theoretically interpreted and the energy parameters have been determined by a least squares fit to the observed levels. A comparison of parameters in Cr III and Fe V ions is given. (orig.)

3D detectors with high space and time resolution

Science.gov (United States)

Loi, A.

2018-01-01

For future high luminosity LHC experiments it will be important to develop new detector systems with increased space and time resolution and also better radiation hardness in order to operate in high luminosity environment. A possible technology which could give such performances is 3D silicon detectors. This work explores the possibility of a pixel geometry by designing and simulating different solutions, using Sentaurus Tecnology Computer Aided Design (TCAD) as design and simulation tool, and analysing their performances. A key factor during the selection was the generated electric field and the carrier velocity inside the active area of the pixel.

Multiple matching scheme for broadband 0.72Pb(Mg1∕3Nb2∕3)O3−0.28PbTiO3 single crystal phased-array transducer

Science.gov (United States)

Lau, S. T.; Li, H.; Wong, K. S.; Zhou, Q. F.; Zhou, D.; Li, Y. C.; Luo, H. S.; Shung, K. K.; Dai, J. Y.

2009-01-01

Lead magnesium niobate–lead titanate single crystal 0.72Pb(Mg1∕3Nb2∕3)O3−0.28PbTiO3 (abbreviated as PMN-PT) was used to fabricate high performance ultrasonic phased-array transducer as it exhibited excellent piezoelectric properties. In this paper, we focus on the design and fabrication of a low-loss and wide-band transducer for medical imaging applications. A KLM model based simulation software PiezoCAD was used for acoustic design of the transducer including the front-face matching and backing. The calculated results show that the −6 dB transducer bandwidth can be improved significantly by using double λ∕8 matching layers and hard backing. A 4.0 MHz PMN-PT transducer array (with 16 elements) was fabricated and tested in a pulse-echo arrangement. A −6 dB bandwidth of 110% and two-way insertion loss of −46.5 dB were achieved. PMID:19657405

A hybrid breath hold and continued respiration-triggered technique for time-resolved 3D MRI perfusion studies in lung cancer

International Nuclear Information System (INIS)

Hintze, C.; Stemmer, A.; Bock, M.

2010-01-01

Assessment of lung cancer perfusion is impaired by respiratory motion. Imaging times for contrast agent wash-out studies often exceed breath hold capabilities, and respiration triggering reduces temporal resolution. Temporally resolved volume acquisition of entire tumors is required to assess heterogeneity. Therefore, we developed and evaluated an MR measurement technique that exceeds a single breath hold, and provides a variable temporal resolution during acquisition while suspending breath-dependent motion. 20 patients with suspected lung cancer were subjected to perfusion studies using a spoiled 3D gradient echo sequence after bolus injection of 0.07 mmol/kg body weight of Gd-DTPA. 10 acquisitions in expiratory breath hold were followed by 50 navigator-triggered acquisitions under free breathing. Post-processing allowed for co-registration of the 3D data sets. An ROI-based visualization of the signal-time curves was performed. In all cases motion-suspended, time-resolved volume data sets (40 x 33 x 10 cm 3 , voxel size: 2.1 x 2.1 x 5.0 mm 3 ) were generated with a variable, initially high temporal resolution (2.25 sec) that was synchronized with the breath pattern and covered up to 8(1)/(2) min. In 7 / 20 cases a remaining offset could be reduced by rigid co-registration. The tumors showed fast wash-in, followed by rapid signal decay (8 / 20) or a plateau. The feasibility of a perfusion study with hybrid breath hold and navigator-triggered time-resolved 3D MRI which combines high initial temporal resolution during breath hold with a long wash-out period under free breathing was demonstrated. (orig.)

CROSS DRIVE: A New Interactive and Immersive Approach for Exploring 3D Time-Dependent Mars Atmospheric Data in Distributed Teams

Science.gov (United States)

Gerndt, Andreas M.; Engelke, Wito; Giuranna, Marco; Vandaele, Ann C.; Neary, Lori; Aoki, Shohei; Kasaba, Yasumasa; Garcia, Arturo; Fernando, Terrence; Roberts, David; CROSS DRIVE Team

2016-10-01

Atmospheric phenomena of Mars can be highly dynamic and have daily and seasonal variations. Planetary-scale wavelike disturbances, for example, are frequently observed in Mars' polar winter atmosphere. Possible sources of the wave activity were suggested to be dynamical instabilities and quasi-stationary planetary waves, i.e. waves that arise predominantly via zonally asymmetric surface properties. For a comprehensive understanding of these phenomena, single layers of altitude have to be analyzed carefully and relations between different atmospheric quantities and interaction with the surface of Mars have to be considered. The CROSS DRIVE project tries to address the presentation of those data with a global view by means of virtual reality techniques. Complex orbiter data from spectrometer and observation data from Earth are combined with global circulation models and high-resolution terrain data and images available from Mars Express or MRO instruments. Scientists can interactively extract features from those dataset and can change visualization parameters in real-time in order to emphasize findings. Stereoscopic views allow for perception of the actual 3D behavior of Mars's atmosphere. A very important feature of the visualization system is the possibility to connect distributed workspaces together. This enables discussions between distributed working groups. The workspace can scale from virtual reality systems to expert desktop applications to web-based project portals. If multiple virtual environments are connected, the 3D position of each individual user is captured and used to depict the scientist as an avatar in the virtual world. The appearance of the avatar can also scale from simple annotations to complex avatars using tele-presence technology to reconstruct the users in 3D. Any change of the feature set (annotations, cutplanes, volume rendering, etc.) within the VR is immediately exchanged between all connected users. This allows that everybody is always

3D seismic data de-noising and reconstruction using Multichannel Time Slice Singular Spectrum Analysis

Science.gov (United States)

Rekapalli, Rajesh; Tiwari, R. K.; Sen, Mrinal K.; Vedanti, Nimisha

2017-05-01

Noises and data gaps complicate the seismic data processing and subsequently cause difficulties in the geological interpretation. We discuss a recent development and application of the Multi-channel Time Slice Singular Spectrum Analysis (MTSSSA) for 3D seismic data de-noising in time domain. In addition, L1 norm based simultaneous data gap filling of 3D seismic data using MTSSSA also discussed. We discriminated the noises from single individual time slices of 3D volumes by analyzing Eigen triplets of the trajectory matrix. We first tested the efficacy of the method on 3D synthetic seismic data contaminated with noise and then applied to the post stack seismic reflection data acquired from the Sleipner CO2 storage site (pre and post CO2 injection) from Norway. Our analysis suggests that the MTSSSA algorithm is efficient to enhance the S/N for better identification of amplitude anomalies along with simultaneous data gap filling. The bright spots identified in the de-noised data indicate upward migration of CO2 towards the top of the Utsira formation. The reflections identified applying MTSSSA to pre and post injection data correlate well with the geology of the Southern Viking Graben (SVG).

Time-dependent approach to collisional ionization using exterior complex scaling

International Nuclear Information System (INIS)

McCurdy, C. William; Horner, Daniel A.; Rescigno, Thomas N.

2002-01-01

We present a time-dependent formulation of the exterior complex scaling method that has previously been used to treat electron-impact ionization of the hydrogen atom accurately at low energies. The time-dependent approach solves a driven Schroedinger equation, and scales more favorably with the number of electrons than the original formulation. The method is demonstrated in calculations for breakup processes in two dimensions (2D) and three dimensions for systems involving short-range potentials and in 2D for electron-impact ionization in the Temkin-Poet model for electron-hydrogen atom collisions

Intracranial MRA: single volume vs. multiple thin slab 3D time-of-flight acquisition.

Science.gov (United States)

Davis, W L; Warnock, S H; Harnsberger, H R; Parker, D L; Chen, C X

1993-01-01

Single volume three-dimensional (3D) time-of-flight (TOF) MR angiography is the most commonly used noninvasive method for evaluating the intracranial vasculature. The sensitivity of this technique to signal loss from flow saturation limits its utility. A recently developed multislab 3D TOF technique, MOTSA, is less affected by flow saturation and would therefore be expected to yield improved vessel visualization. To study this hypothesis, intracranial MR angiograms were obtained on 10 volunteers using three techniques: MOTSA, single volume 3D TOF using a standard 4.9 ms TE (3D TOFA), and single volume 3D TOF using a 6.8 ms TE (3D TOFB). All three sets of axial source images and maximum intensity projection (MIP) images were reviewed. Each exam was evaluated for the number of intracranial vessels visualized. A total of 502 vessel segments were studied with each technique. With use of the MIP images, 86% of selected vessels were visualized with MOTSA, 64% with 3D TOFA (TE = 4.9 ms), and 67% with TOFB (TE = 6.8 ms). Similarly, with the axial source images, 91% of selected vessels were visualized with MOTSA, 77% with 3D TOFA (TE = 4.9 ms), and 82% with 3D TOFB (TE = 6.8 ms). There is improved visualization of selected intracranial vessels in normal volunteers with MOTSA as compared with single volume 3D TOF. These improvements are believed to be primarily a result of decreased sensitivity to flow saturation seen with the MOTSA technique. No difference in overall vessel visualization was noted for the two single volume 3D TOF techniques.

Podosomes, But Not the Maturation Status, Determine the Protease-Dependent 3D Migration in Human Dendritic Cells.

Science.gov (United States)

Cougoule, Céline; Lastrucci, Claire; Guiet, Romain; Mascarau, Rémi; Meunier, Etienne; Lugo-Villarino, Geanncarlo; Neyrolles, Olivier; Poincloux, Renaud; Maridonneau-Parini, Isabelle

2018-01-01

Dendritic cells (DC) are professional Antigen-Presenting Cells scattered throughout antigen-exposed tissues and draining lymph nodes, and survey the body for pathogens. Their ability to migrate through tissues, a 3D environment, is essential for an effective immune response. Upon infection, recognition of Pathogen-Associated Molecular Patterns (PAMP) by Toll-like receptors (TLR) triggers DC maturation. Mature DC (mDC) essentially use the protease-independent, ROCK-dependent amoeboid mode in vivo , or in collagen matrices in vitro . However, the mechanisms of 3D migration used by human immature DC (iDC) are still poorly characterized. Here, we reveal that human monocyte-derived DC are able to use two migration modes in 3D. In porous matrices of fibrillar collagen I, iDC adopted the amoeboid migration mode. In dense matrices of gelled collagen I or Matrigel, iDC used the protease-dependent, ROCK-independent mesenchymal migration mode. Upon TLR4 activation by LPS, mDC-LPS lose the capacity to form podosomes and degrade the matrix along with impaired mesenchymal migration. TLR2 activation by Pam 3 CSK 4 resulted in DC maturation, podosome maintenance, and efficient mesenchymal migration. Under all these conditions, when DC used the mesenchymal mode in dense matrices, they formed 3D podosomes at the tip of cell protrusions. Using PGE 2 , known to disrupt podosomes in DC, we observed that the cells remained in an immature status and the mesenchymal migration mode was abolished. We also observed that, while CCL5 (attractant of iDC) enhanced both amoeboid and mesenchymal migration of iDC, CCL19 and CCL21 (attractants of mDC) only enhanced mDC-LPS amoeboid migration without triggering mesenchymal migration. Finally, we examined the migration of iDC in tumor cell spheroids, a tissue-like 3D environment. We observed that iDC infiltrated spheroids of tumor cells using both migration modes. Altogether, these results demonstrate that human DC adopt the mesenchymal mode to

FALL3D: A computational model for transport and deposition of volcanic ash

Science.gov (United States)

Folch, A.; Costa, A.; Macedonio, G.

2009-06-01

FALL3D is a 3-D time-dependent Eulerian model for the transport and deposition of volcanic ashes and lapilli. The model solves the advection-diffusion-sedimentation (ADS) equation on a structured terrain-following grid using a second-order finite differences (FD) explicit scheme. Different parameterizations for the eddy diffusivity tensor and for the particle terminal settling velocities can be used. The code, written in FORTRAN 90, is available in both serial and parallel versions for Windows and Unix/Linux/Mac X operating systems (OS). A series of pre- and post-process utility programs and OS-dependent scripts to launch them are also included in the FALL3D distribution package. Although the model has been designed to forecast volcanic ash concentration in the atmosphere and ash loading at ground, it can also be used to model the transport of any kind of airborne solid particles. The model inputs are meteorological data, topography, grain-size distribution, shape and density of particles, and mass rate of particle injected into the atmosphere. Optionally, FALL3D can be coupled with the output of the meteorological processor CALMET, a diagnostic model which generates 3-D time-dependent zero-divergence wind fields from mesoscale forecasts incorporating local terrain effects. The FALL3D model can be a tool for short-term ash deposition forecasting and for volcanic fallout hazard assessment. As an example, an application to the 22 July 1998 Etna eruption is also presented.

A PHASE-I STUDY OF IOBAPLATIN (D-19466) ADMINISTERED BY 72H CONTINUOUS INFUSION

NARCIS (Netherlands)

GIETEMA, JA; GUCHELAAR, HJ; DEVRIES, EGE; AULENBACHER, P; SLEIJFER, DT; MULDER, NH

A phase I trial with continuous intravenous infusion of lobaplatin (D-19466; 1,2-diamminomethyl-cyclobutane-platinum (II)-lactate) for 72 h was performed to determine the maximum tolerated dose (MTD). Each patient received a single dose level, the total dose of lobaplatin ranged from 30 to 60

FORESHOCKS AND TIME-DEPENDENT EARTHQUAKE HAZARD ASSESSMENT IN SOUTHERN CALIFORNIA.

Science.gov (United States)

Jones, Lucile M.

1985-01-01

The probability that an earthquake in southern California (M greater than equivalent to 3. 0) will be followed by an earthquake of larger magnitude within 5 days and 10 km (i. e. , will be a foreshock) is 6 plus or minus 0. 5 per cent (1 S. D. ), and is not significantly dependent on the magnitude of the possible foreshock between M equals 3 and M equals 5. The probability that an earthquake will be followed by an M greater than equivalent to 5. 0 main shock, however, increases with magnitude of the foreshock from less than 1 per cent at M greater than equivalent to 3 to 6. 5 plus or minus 2. 5 per cent (1 S. D. ) at M greater than equivalent to 5. The main shock will most likely occur in the first hour after the foreshock, and the probability that a main shock will occur in the first hour decreases with elapsed time from the occurrence of the possible foreshock by approximately the inverse of time. Thus, the occurrence of an earthquake of M greater than equivalent to 3. 0 in southern California increases the earthquake hazard within a small space-time window several orders of magnitude above the normal background level.

Preparation and biological evaluation of 111In-, 177Lu- and 90Y-labeled DOTA analogues conjugated to B72.3

International Nuclear Information System (INIS)

Mohsin, Huma; Fitzsimmons, Jonathan; Shelton, Tiffani; Hoffman, Timothy J.; Cutler, Cathy S.; Lewis, Michael R.; Athey, Phillip S.; Gulyas, Gyongyi; Kiefer, Garry E.; Frank, R. Keith; Simon, Jaime; Lever, Susan Z.; Jurisson, Silvia S.

2007-01-01

Three 1,4,7,10-tetraazacyclododecane-N,N',N '' ,N '' '-tetraacetic acid (DOTA) analogues were evaluated for relative in vivo stability when radiolabeled with 111 In, 90 Y and 177 Lu and conjugated to the monoclonal antibody B72.3. The DOTA analogues evaluated were 'NHS-DOTA' [N-hydroxysuccinimdyl (NHS) group activating one carboxylate], 'Arm-DOTA' (also known as MeO-DOTA; with a p-NCS, o-MeO-benzyl moiety on the methylene group of one acetic acid arm) and 'Back-DOTA' (with a p-NCS-benzyl moiety on a backbone methylene group of the macrocycle). The B72.3 was conjugated to the DOTA analogues to increase the retention time of the radioloabeled conjugates in vivo in mice. The serum stability of the various radiometalated DOTA conjugates showed them to have good stability out to 168 h (all >95% except 111 In-NHS-DOTA-B72.3, which was 91% stable). Hydroxyapatite stability for the 111 In and 177 Lu DOTA-conjugates was >95% at 168 h, while the 90 Y DOTA-conjugates were somewhat less stable (between 90% and 95% at 168 h). The biodistribution studies of the radiometalated DOTA-conjugates showed that no significant differences were observed for the 111 In and 177 Lu analogues; however, the 90 Y analogues showed lower stabilities, as evidenced by their increased bone uptake relative to the other two [2-20% injected dose per gram (% ID/g) for 90 Y and 2-8% ID/g for 111 In and 177 Lu]. The lower stability of the 90 Y analogues could be due to the higher beta energy of 90 Y and/or to the larger ionic radius of Y 3+ . Based on the bone uptake observed, the 177 Lu-NHS-DOTA-B72.3 had slightly lower stability than the 177 Lu-Arm-DOTA-B72.3 and 177 Lu-Back-DOTA-B72.3, but not significantly at all time points. For 90 Y, the analogue showing the lowest stability based on bone uptake was 90 Y-Arm-DOTA-B72.3, perhaps because of the metal's larger ionic radius and potential steric interactions minimizing effective complexation. The 111 In analogues all showed similar biological

Audiovisual biofeedback improves image quality and reduces scan time for respiratory-gated 3D MRI

International Nuclear Information System (INIS)

Lee, D; Keall, P; Kim, T; Greer, P B; Arm, J

2014-01-01

The purpose of this study was to test the hypothesis that audiovisual (AV) biofeedback can improve image quality and reduce scan time for respiratory-gated 3D thoracic MRI. For five healthy human subjects respiratory motion guidance in MR scans was provided using an AV biofeedback system, utilizing real-time respiratory motion signals. To investigate the improvement of respiratory-gated 3D MR images between free breathing (FB) and AV biofeedback (AV), each subject underwent two imaging sessions. Respiratory-related motion artifacts and imaging time were qualitatively evaluated in addition to the reproducibility of external (abdominal) motion. In the results, 3D MR images in AV biofeedback showed more anatomic information such as a clear distinction of diaphragm, lung lobes and sharper organ boundaries. The scan time was reduced from 401±215 s in FB to 334±94 s in AV (p-value 0.36). The root mean square variation of the displacement and period of the abdominal motion was reduced from 0.4±0.22 cm and 2.8±2.5 s in FB to 0.1±0.15 cm and 0.9±1.3 s in AV (p-value of displacement <0.01 and p-value of period 0.12). This study demonstrated that audiovisual biofeedback improves image quality and reduces scan time for respiratory-gated 3D MRI. These results suggest that AV biofeedback has the potential to be a useful motion management tool in medical imaging and radiation therapy procedures.

CASTLE3D - A Computer Aided System for Labelling Archaeological Excavations in 3D

Science.gov (United States)

Houshiar, H.; Borrmann, D.; Elseberg, J.; Nüchter, A.; Näth, F.; Winkler, S.

2015-08-01

Documentation of archaeological excavation sites with conventional methods and tools such as hand drawings, measuring tape and archaeological notes is time consuming. This process is prone to human errors and the quality of the documentation depends on the qualification of the archaeologist on site. Use of modern technology and methods in 3D surveying and 3D robotics facilitate and improve this process. Computer-aided systems and databases improve the documentation quality and increase the speed of data acquisition. 3D laser scanning is the state of the art in modelling archaeological excavation sites, historical sites and even entire cities or landscapes. Modern laser scanners are capable of data acquisition of up to 1 million points per second. This provides a very detailed 3D point cloud of the environment. 3D point clouds and 3D models of an excavation site provide a better representation of the environment for the archaeologist and for documentation. The point cloud can be used both for further studies on the excavation and for the presentation of results. This paper introduces a Computer aided system for labelling archaeological excavations in 3D (CASTLE3D). Consisting of a set of tools for recording and georeferencing the 3D data from an excavation site, CASTLE3D is a novel documentation approach in industrial archaeology. It provides a 2D and 3D visualisation of the data and an easy-to-use interface that enables the archaeologist to select regions of interest and to interact with the data in both representations. The 2D visualisation and a 3D orthogonal view of the data provide cuts of the environment that resemble the traditional hand drawings. The 3D perspective view gives a realistic view of the environment. CASTLE3D is designed as an easy-to-use on-site semantic mapping tool for archaeologists. Each project contains a predefined set of semantic information that can be used to label findings in the data. Multiple regions of interest can be joined under

Genetics Home Reference: vitamin D-dependent rickets

Science.gov (United States)

... Conditions Vitamin D-dependent rickets Vitamin D-dependent rickets Printable PDF Open All Close All Enable Javascript ... the expand/collapse boxes. Description Vitamin D-dependent rickets is a disorder of bone development that leads ...

An evolution from 3D face-centered-cubic ZnSnO3 nanocubes to 2D orthorhombic ZnSnO3 nanosheets with excellent gas sensing performance

International Nuclear Information System (INIS)

Chen Yuejiao; Yu Ling; Li Qing; Wu Yan; Li Qiuhong; Wang Taihong

2012-01-01

We have successfully observed the development of three-dimensional (3D) face-centered-cubic ZnSnO 3 into two-dimensional (2D) orthorhombic ZnSnO 3 nanosheets, which is the first observation of 2D ZnSnO 3 nanostructures to date. The synthesis from 3D to 2D nanostructures is realized by the dual-hydrolysis-assisted liquid precipitation reaction and subsequent hydrothermal treatment. The time-dependent morphology indicates the transformation via a ‘dissolution–recrystallization’ mechanism, accompanied by a ‘further growth’ process. Furthermore, the 2D ZnSnO 3 nanosheets consist of smaller sized nanoflakes. This further increases the special specific surface area and facilitates their application in gas sensing. The 2D ZnSnO 3 nanosheets exhibit excellent gas sensing properties, especially through their ultra-fast response and recovery. When exposed to ethanol and acetone, the response rate is as fast as 0.26 s and 0.18 s, respectively, and the concentration limit can reach as low as 50 ppb of ethanol. All these results are much better than those reported so far. Our experimental results indicate an efficient approach to realize high-performance gas sensors. (paper)

A real-time 3D end-to-end augmented reality system (and its representation transformations)

Science.gov (United States)

Tytgat, Donny; Aerts, Maarten; De Busser, Jeroen; Lievens, Sammy; Rondao Alface, Patrice; Macq, Jean-Francois

2016-09-01

The new generation of HMDs coming to the market is expected to enable many new applications that allow free viewpoint experiences with captured video objects. Current applications usually rely on 3D content that is manually created or captured in an offline manner. In contrast, this paper focuses on augmented reality applications that use live captured 3D objects while maintaining free viewpoint interaction. We present a system that allows live dynamic 3D objects (e.g. a person who is talking) to be captured in real-time. Real-time performance is achieved by traversing a number of representation formats and exploiting their specific benefits. For instance, depth images are maintained for fast neighborhood retrieval and occlusion determination, while implicit surfaces are used to facilitate multi-source aggregation for both geometry and texture. The result is a 3D reconstruction system that outputs multi-textured triangle meshes at real-time rates. An end-to-end system is presented that captures and reconstructs live 3D data and allows for this data to be used on a networked (AR) device. For allocating the different functional blocks onto the available physical devices, a number of alternatives are proposed considering the available computational power and bandwidth for each of the components. As we will show, the representation format can play an important role in this functional allocation and allows for a flexible system that can support a highly heterogeneous infrastructure.

Chronic electroconvulsive stimulation but not chronic restraint stress modulates mRNA expression of voltage-dependent potassium channels Kv7.2 and Kv11.1 in the rat piriform cortex

DEFF Research Database (Denmark)

Hjæresen, Marie-Louise; Hageman, Ida; Wörtwein, Gitta

2008-01-01

The mechanisms by which stress and electroconvulsive therapy exert opposite effects on the course of major depression are not known. Potential candidates might include the voltage-dependent potassium channels. Potassium channels play an important role in maintaining the resting membrane potential...... and controlling neuronal excitability. To explore this hypothesis, we examined the effects of one or several electroconvulsive stimulations and chronic restraint stress (6 h/day for 21 days) on the expression of voltage-dependent potassium channel Kv7.2, Kv11.1, and Kv11.3 mRNA in the rat brain using in situ...... hybridization. Repeated, but not acute, electroconvulsive stimulation increased Kv7.2 and Kv11.1 mRNA levels in the piriform cortex. In contrast, restraint stress had no significant effect on mRNA expression of Kv7.2, Kv11.1, or Kv11.3 in any of the brain regions examined. Thus, it appears that the investigated...

Online 3D EPID-based dose verification: Proof of concept

Energy Technology Data Exchange (ETDEWEB)

Spreeuw, Hanno; Rozendaal, Roel, E-mail: r.rozendaal@nki.nl; Olaciregui-Ruiz, Igor; González, Patrick; Mans, Anton; Mijnheer, Ben [Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam 1066 CX (Netherlands); Herk, Marcel van [University of Manchester, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Manchester M20 4BX (United Kingdom)

2016-07-15

Purpose: Delivery errors during radiotherapy may lead to medical harm and reduced life expectancy for patients. Such serious incidents can be avoided by performing dose verification online, i.e., while the patient is being irradiated, creating the possibility of halting the linac in case of a large overdosage or underdosage. The offline EPID-based 3D in vivo dosimetry system clinically employed at our institute is in principle suited for online treatment verification, provided the system is able to complete 3D dose reconstruction and verification within 420 ms, the present acquisition time of a single EPID frame. It is the aim of this study to show that our EPID-based dosimetry system can be made fast enough to achieve online 3D in vivo dose verification. Methods: The current dose verification system was sped up in two ways. First, a new software package was developed to perform all computations that are not dependent on portal image acquisition separately, thus removing the need for doing these calculations in real time. Second, the 3D dose reconstruction algorithm was sped up via a new, multithreaded implementation. Dose verification was implemented by comparing planned with reconstructed 3D dose distributions delivered to two regions in a patient: the target volume and the nontarget volume receiving at least 10 cGy. In both volumes, the mean dose is compared, while in the nontarget volume, the near-maximum dose (D2) is compared as well. The real-time dosimetry system was tested by irradiating an anthropomorphic phantom with three VMAT plans: a 6 MV head-and-neck treatment plan, a 10 MV rectum treatment plan, and a 10 MV prostate treatment plan. In all plans, two types of serious delivery errors were introduced. The functionality of automatically halting the linac was also implemented and tested. Results: The precomputation time per treatment was ∼180 s/treatment arc, depending on gantry angle resolution. The complete processing of a single portal frame

Online 3D EPID-based dose verification: Proof of concept

International Nuclear Information System (INIS)

Spreeuw, Hanno; Rozendaal, Roel; Olaciregui-Ruiz, Igor; González, Patrick; Mans, Anton; Mijnheer, Ben; Herk, Marcel van

2016-01-01

Purpose: Delivery errors during radiotherapy may lead to medical harm and reduced life expectancy for patients. Such serious incidents can be avoided by performing dose verification online, i.e., while the patient is being irradiated, creating the possibility of halting the linac in case of a large overdosage or underdosage. The offline EPID-based 3D in vivo dosimetry system clinically employed at our institute is in principle suited for online treatment verification, provided the system is able to complete 3D dose reconstruction and verification within 420 ms, the present acquisition time of a single EPID frame. It is the aim of this study to show that our EPID-based dosimetry system can be made fast enough to achieve online 3D in vivo dose verification. Methods: The current dose verification system was sped up in two ways. First, a new software package was developed to perform all computations that are not dependent on portal image acquisition separately, thus removing the need for doing these calculations in real time. Second, the 3D dose reconstruction algorithm was sped up via a new, multithreaded implementation. Dose verification was implemented by comparing planned with reconstructed 3D dose distributions delivered to two regions in a patient: the target volume and the nontarget volume receiving at least 10 cGy. In both volumes, the mean dose is compared, while in the nontarget volume, the near-maximum dose (D2) is compared as well. The real-time dosimetry system was tested by irradiating an anthropomorphic phantom with three VMAT plans: a 6 MV head-and-neck treatment plan, a 10 MV rectum treatment plan, and a 10 MV prostate treatment plan. In all plans, two types of serious delivery errors were introduced. The functionality of automatically halting the linac was also implemented and tested. Results: The precomputation time per treatment was ∼180 s/treatment arc, depending on gantry angle resolution. The complete processing of a single portal frame

Online 3D EPID-based dose verification: Proof of concept.

Science.gov (United States)

Spreeuw, Hanno; Rozendaal, Roel; Olaciregui-Ruiz, Igor; González, Patrick; Mans, Anton; Mijnheer, Ben; van Herk, Marcel

2016-07-01

Delivery errors during radiotherapy may lead to medical harm and reduced life expectancy for patients. Such serious incidents can be avoided by performing dose verification online, i.e., while the patient is being irradiated, creating the possibility of halting the linac in case of a large overdosage or underdosage. The offline EPID-based 3D in vivo dosimetry system clinically employed at our institute is in principle suited for online treatment verification, provided the system is able to complete 3D dose reconstruction and verification within 420 ms, the present acquisition time of a single EPID frame. It is the aim of this study to show that our EPID-based dosimetry system can be made fast enough to achieve online 3D in vivo dose verification. The current dose verification system was sped up in two ways. First, a new software package was developed to perform all computations that are not dependent on portal image acquisition separately, thus removing the need for doing these calculations in real time. Second, the 3D dose reconstruction algorithm was sped up via a new, multithreaded implementation. Dose verification was implemented by comparing planned with reconstructed 3D dose distributions delivered to two regions in a patient: the target volume and the nontarget volume receiving at least 10 cGy. In both volumes, the mean dose is compared, while in the nontarget volume, the near-maximum dose (D2) is compared as well. The real-time dosimetry system was tested by irradiating an anthropomorphic phantom with three VMAT plans: a 6 MV head-and-neck treatment plan, a 10 MV rectum treatment plan, and a 10 MV prostate treatment plan. In all plans, two types of serious delivery errors were introduced. The functionality of automatically halting the linac was also implemented and tested. The precomputation time per treatment was ∼180 s/treatment arc, depending on gantry angle resolution. The complete processing of a single portal frame, including dose verification, took

Detection of radiation transitions between 4d9(D5/3,3/2)5s2nl and 4d105p(2P1/2,3/20)nl of self-ionized states of cadmium atom at electron-ion collisions

International Nuclear Information System (INIS)

Gomonaj, A.N.; Imre, A.I.

2005-01-01

Radiation transitions between 4d 9 ( 2 D 5/2,3/2 )5s 2 nl and 4d 10 5p( 2 P 1/2,3/2 0 )nl self-ionized states of Cd atom being dielectron satellites of λ325.0 nm (4d 9 5s 22 D 3/2 →4d 10 5p 2 P 1/2 0 ) and λ353.6 nm (4d 9 5s 22 D 3/2 → 4d 10 5p 2 P 3/2 0 ) laser lines of Cd + ion were detected for the first time at electron-ion collisions. One studied energy dependences of the effective cross sections of electron excitation of the satellite lines within 7-10 eV energy range. The effective cross sections of excitation of dielectron satellites constitutes ∼ 10 -17 cm 2 that is comparable with the efficiency of excitation of the laser lines [ru

Real-time registration of 3D to 2D ultrasound images for image-guided prostate biopsy.

Science.gov (United States)

Gillies, Derek J; Gardi, Lori; De Silva, Tharindu; Zhao, Shuang-Ren; Fenster, Aaron

2017-09-01

During image-guided prostate biopsy, needles are targeted at tissues that are suspicious of cancer to obtain specimen for histological examination. Unfortunately, patient motion causes targeting errors when using an MR-transrectal ultrasound (TRUS) fusion approach to augment the conventional biopsy procedure. This study aims to develop an automatic motion correction algorithm approaching the frame rate of an ultrasound system to be used in fusion-based prostate biopsy systems. Two modes of operation have been investigated for the clinical implementation of the algorithm: motion compensation using a single user initiated correction performed prior to biopsy, and real-time continuous motion compensation performed automatically as a background process. Retrospective 2D and 3D TRUS patient images acquired prior to biopsy gun firing were registered using an intensity-based algorithm utilizing normalized cross-correlation and Powell's method for optimization. 2D and 3D images were downsampled and cropped to estimate the optimal amount of image information that would perform registrations quickly and accurately. The optimal search order during optimization was also analyzed to avoid local optima in the search space. Error in the algorithm was computed using target registration errors (TREs) from manually identified homologous fiducials in a clinical patient dataset. The algorithm was evaluated for real-time performance using the two different modes of clinical implementations by way of user initiated and continuous motion compensation methods on a tissue mimicking prostate phantom. After implementation in a TRUS-guided system with an image downsampling factor of 4, the proposed approach resulted in a mean ± std TRE and computation time of 1.6 ± 0.6 mm and 57 ± 20 ms respectively. The user initiated mode performed registrations with in-plane, out-of-plane, and roll motions computation times of 108 ± 38 ms, 60 ± 23 ms, and 89 ± 27 ms, respectively, and corresponding

70Ge, 72Ge, 74Ge, 76Ge(d,3He)69Ga, 71Ga, 73Ga, 75Ga reactions at 26 MeV

International Nuclear Information System (INIS)

Rotbard, G.; La Rana, G.; Vergnes, M.; Berrier, G.; Kalifa, J.; Guilbaut, G.; Tamisier, R.

1978-01-01

The 70 Ge, 72 Ge, 74 Ge, 76 Ge(d, 3 He) 69 Ga, 71 Ga, 73 Ga, 75 Ga reactions have been studied at 26 MeV with 15 keV resolution (F.W.H.M), using the Orsay MP tandem accelerator and a split pole magnetic spectrometer. The spectroscopic factors are determined for 15 levels in 69 Ga and 11 levels in each of the 3 other Ga isotopes. Level schemes are proposed for the practically unknown 73 Ga and 75 Ga. Very simple model wave functions previously proposed for Ge nuclei are seen to reproduce quite well the measured occupation numbers for the proton orbitals. Anomalies in these occupation numbers are observed between Z=31 and 32 and between N=40 and 42, this last one corresponding to the structural transition observed recently in a comparison of the (p,t) and (t,p) reactions. These anomalies could be related to changes in the nuclear shape

Production of d, t, 3He, anti d, anti t and anti 3He by 200 GeV protons

International Nuclear Information System (INIS)

Bozzoli, W.; Giacomelli, G.; Rimondi, F.; Zylberajch, S.; Lesquoy, E.; Meunier, R.; Moscoso, L.; Muller, A.; Bussiere, A.

1978-01-01

Data are presented on the yields of d, t, 3 He, anti d, anti t, and anti 3 He with laboratory momenta between 12 and 37 GeV/c produced by 200 GeV protons on beryllium and aluminium. The production yield of nuclei depends significantly on the target nucleus, while the anti d production is independent of target material. The mass dependence of the production cross section is exponential for both nuclei and antinuclei

Modeling time-dependent corrosion fatigue crack propagation in 7000 series aluminum alloys

Science.gov (United States)

Mason, Mark E.; Gangloff, Richard P.

1994-01-01

Stress corrosion cracking and corrosion fatigue experiments were conducted with the susceptible S-L orientation of AA7075-T651, immersed in acidified and inhibited NaCl solution, to provide a basis for incorporating environmental effects into fatigue crack propagation life prediction codes such as NASA FLAGRO. This environment enhances da/dN by five to ten-fold compared to fatigue in moist air. Time-based crack growth rates from quasi-static load experiments are an order of magnitude too small for accurate linear superposition prediction of da/dN for loading frequencies above 0.001 Hz. Alternate methods of establishing da/dt, based on rising-load or ripple-load-enhanced crack tip strain rate, do not increase da/dt and do not improve linear superposition. Corrosion fatigue is characterized by two regimes of frequency dependence; da/dN is proportional to f(exp -1) below 0.001 Hz and to F(exp 0) to F(exp -0.1) for higher frequencies. Da/dN increases mildly both with increasing hold-time at K(sub max) and with increasing rise-time for a range of loading waveforms. The mild time-dependence is due to cycle-time-dependent corrosion fatigue growth. This behavior is identical for S-L nd L-T crack orientations. The frequency response of environmental fatigue in several 7000 series alloys is variable and depends on undefined compositional or microstructural variables. Speculative explanations are based on the effect of Mg on occluded crack chemistry and embritting hydrogen uptake, or on variable hydrogen diffusion in the crack tip process zone. Cracking in the 7075/NaCl system is adequately described for life prediction by linear superposition for prolonged load-cycle periods, and by a time-dependent upper bound relationship between da/dN and delta K for moderate loading times.

E3D, 3-D Elastic Seismic Wave Propagation Code

International Nuclear Information System (INIS)

Larsen, S.; Harris, D.; Schultz, C.; Maddix, D.; Bakowsky, T.; Bent, L.

2004-01-01

1 - Description of program or function: E3D is capable of simulating seismic wave propagation in a 3D heterogeneous earth. Seismic waves are initiated by earthquake, explosive, and/or other sources. These waves propagate through a 3D geologic model, and are simulated as synthetic seismograms or other graphical output. 2 - Methods: The software simulates wave propagation by solving the elasto-dynamic formulation of the full wave equation on a staggered grid. The solution scheme is 4-order accurate in space, 2-order accurate in time

Time-dependent embedding

OpenAIRE

Inglesfield, J. E.

2007-01-01

A method of solving the time-dependent Schr\\"odinger equation is presented, in which a finite region of space is treated explicitly, with the boundary conditions for matching the wave-functions on to the rest of the system replaced by an embedding term added on to the Hamiltonian. This time-dependent embedding term is derived from the Fourier transform of the energy-dependent embedding potential, which embeds the time-independent Schr\\"odinger equation. Results are presented for a one-dimensi...

Constant resolution of time-dependent Hartree--Fock phase ambiguity

International Nuclear Information System (INIS)

Lichtner, P.C.; Griffin, J.J.; Schultheis, H.; Schultheis, R.; Volkov, A.B.

1978-01-01

The customary time-dependent Hartree--Fock problem is shown to be ambiguous up to an arbitrary function of time additive to H/sub HF/, and, consequently, up to an arbitrary time-dependent phase for the solution, PHI(t). The ''constant'' (H)'' phase is proposed as the best resolution of this ambiguity. It leads to the following attractive features: (a) the time-dependent Hartree--Fock (TDHF) Hamiltonian, H/sub HF/, becomes a quantity whose expectation value is equal to the average energy and, hence, constant in time; (b) eigenstates described exactly by determinants, have time-dependent Hartree--Fock solutions identical with the exact time-dependent solutions; (c) among all possible TDHF solutions this choice minimizes the norm of the quantity (H--i dirac constant delta/delta t) operating on the ket PHI, and guarantees optimal time evolution over an infinitesimal period; (d) this choice corresponds both to the stationary value of the absolute difference between (H) and (i dirac constant delta/delta t) and simultaneously to its absolute minimal value with respect to choice of the time-dependent phase. The source of the ambiguity is discussed. It lies in the time-dependent generalization of the freedom to transform unitarily among the single-particle states of a determinant at the (physically irrelevant for stationary states) cost of altering only a factor of unit magnitude

3-D electromagnetic modeling for very early time sounding of shallow targets using integral equations

International Nuclear Information System (INIS)

Xiong, Z.; Tripp, A.C.

1994-01-01

This paper presents an integral equation algorithm for 3D EM modeling at high frequencies for applications in engineering an environmental studies. The integral equation method remains the same for low and high frequencies, but the dominant roles of the displacements currents complicate both numerical treatments and interpretations. With singularity extraction technique they successively extended the application of the Hankel filtering technique to the computation of Hankel integrals occurring in high frequency EM modeling. Time domain results are calculated from frequency domain results via Fourier transforms. While frequency domain data are not obvious for interpretations, time domain data show wave-like pictures that resemble seismograms. Both 1D and 3D numerical results show clearly the layer interfaces

The time-dependent density matrix renormalisation group method

Science.gov (United States)

Ma, Haibo; Luo, Zhen; Yao, Yao

2018-04-01

Substantial progress of the time-dependent density matrix renormalisation group (t-DMRG) method in the recent 15 years is reviewed in this paper. By integrating the time evolution with the sweep procedures in density matrix renormalisation group (DMRG), t-DMRG provides an efficient tool for real-time simulations of the quantum dynamics for one-dimensional (1D) or quasi-1D strongly correlated systems with a large number of degrees of freedom. In the illustrative applications, the t-DMRG approach is applied to investigate the nonadiabatic processes in realistic chemical systems, including exciton dissociation and triplet fission in polymers and molecular aggregates as well as internal conversion in pyrazine molecule.

3D printing and milling a real-time PCR device for infectious disease diagnostics.

Science.gov (United States)

Mulberry, Geoffrey; White, Kevin A; Vaidya, Manjusha; Sugaya, Kiminobu; Kim, Brian N

2017-01-01

Diagnosing infectious diseases using quantitative polymerase chain reaction (qPCR) offers a conclusive result in determining the infection, the strain or type of pathogen, and the level of infection. However, due to the high-cost instrumentation involved and the complexity in maintenance, it is rarely used in the field to make a quick turnaround diagnosis. In order to provide a higher level of accessibility than current qPCR devices, a set of 3D manufacturing methods is explored as a possible option to fabricate a low-cost and portable qPCR device. The key advantage of this approach is the ability to upload the digital format of the design files on the internet for wide distribution so that people at any location can simply download and feed into their 3D printers for quick manufacturing. The material and design are carefully selected to minimize the number of custom parts that depend on advanced manufacturing processes which lower accessibility. The presented 3D manufactured qPCR device is tested with 20-μL samples that contain various concentrations of lentivirus, the same type as HIV. A reverse-transcription step is a part of the device's operation, which takes place prior to the qPCR step to reverse transcribe the target RNA from the lentivirus into complementary DNA (cDNA). This is immediately followed by qPCR which quantifies the target sequence molecules in the sample during the PCR amplification process. The entire process of thermal control and time-coordinated fluorescence reading is automated by closed-loop feedback and a microcontroller. The resulting device is portable and battery-operated, with a size of 12 × 7 × 6 cm3 and mass of only 214 g. By uploading and sharing the design files online, the presented low-cost qPCR device may provide easier access to a robust diagnosis protocol for various infectious diseases, such as HIV and malaria.

3D printing and milling a real-time PCR device for infectious disease diagnostics

Science.gov (United States)

Mulberry, Geoffrey; White, Kevin A.; Vaidya, Manjusha; Sugaya, Kiminobu

2017-01-01

Diagnosing infectious diseases using quantitative polymerase chain reaction (qPCR) offers a conclusive result in determining the infection, the strain or type of pathogen, and the level of infection. However, due to the high-cost instrumentation involved and the complexity in maintenance, it is rarely used in the field to make a quick turnaround diagnosis. In order to provide a higher level of accessibility than current qPCR devices, a set of 3D manufacturing methods is explored as a possible option to fabricate a low-cost and portable qPCR device. The key advantage of this approach is the ability to upload the digital format of the design files on the internet for wide distribution so that people at any location can simply download and feed into their 3D printers for quick manufacturing. The material and design are carefully selected to minimize the number of custom parts that depend on advanced manufacturing processes which lower accessibility. The presented 3D manufactured qPCR device is tested with 20-μL samples that contain various concentrations of lentivirus, the same type as HIV. A reverse-transcription step is a part of the device’s operation, which takes place prior to the qPCR step to reverse transcribe the target RNA from the lentivirus into complementary DNA (cDNA). This is immediately followed by qPCR which quantifies the target sequence molecules in the sample during the PCR amplification process. The entire process of thermal control and time-coordinated fluorescence reading is automated by closed-loop feedback and a microcontroller. The resulting device is portable and battery-operated, with a size of 12 × 7 × 6 cm3 and mass of only 214 g. By uploading and sharing the design files online, the presented low-cost qPCR device may provide easier access to a robust diagnosis protocol for various infectious diseases, such as HIV and malaria. PMID:28586401

Parareal in time 3D numerical solver for the LWR Benchmark neutron diffusion transient model

Energy Technology Data Exchange (ETDEWEB)

Baudron, Anne-Marie, E-mail: anne-marie.baudron@cea.fr [Laboratoire de Recherche Conventionné MANON, CEA/DEN/DANS/DM2S and UPMC-CNRS/LJLL (France); CEA-DRN/DMT/SERMA, CEN-Saclay, 91191 Gif sur Yvette Cedex (France); Lautard, Jean-Jacques, E-mail: jean-jacques.lautard@cea.fr [Laboratoire de Recherche Conventionné MANON, CEA/DEN/DANS/DM2S and UPMC-CNRS/LJLL (France); CEA-DRN/DMT/SERMA, CEN-Saclay, 91191 Gif sur Yvette Cedex (France); Maday, Yvon, E-mail: maday@ann.jussieu.fr [Sorbonne Universités, UPMC Univ Paris 06, UMR 7598, Laboratoire Jacques-Louis Lions and Institut Universitaire de France, F-75005, Paris (France); Laboratoire de Recherche Conventionné MANON, CEA/DEN/DANS/DM2S and UPMC-CNRS/LJLL (France); Brown Univ, Division of Applied Maths, Providence, RI (United States); Riahi, Mohamed Kamel, E-mail: riahi@cmap.polytechnique.fr [Laboratoire de Recherche Conventionné MANON, CEA/DEN/DANS/DM2S and UPMC-CNRS/LJLL (France); CMAP, Inria-Saclay and X-Ecole Polytechnique, Route de Saclay, 91128 Palaiseau Cedex (France); Salomon, Julien, E-mail: salomon@ceremade.dauphine.fr [CEREMADE, Univ Paris-Dauphine, Pl. du Mal. de Lattre de Tassigny, F-75016, Paris (France)

2014-12-15

In this paper we present a time-parallel algorithm for the 3D neutrons calculation of a transient model in a nuclear reactor core. The neutrons calculation consists in numerically solving the time dependent diffusion approximation equation, which is a simplified transport equation. The numerical resolution is done with finite elements method based on a tetrahedral meshing of the computational domain, representing the reactor core, and time discretization is achieved using a θ-scheme. The transient model presents moving control rods during the time of the reaction. Therefore, cross-sections (piecewise constants) are taken into account by interpolations with respect to the velocity of the control rods. The parallelism across the time is achieved by an adequate use of the parareal in time algorithm to the handled problem. This parallel method is a predictor corrector scheme that iteratively combines the use of two kinds of numerical propagators, one coarse and one fine. Our method is made efficient by means of a coarse solver defined with large time step and fixed position control rods model, while the fine propagator is assumed to be a high order numerical approximation of the full model. The parallel implementation of our method provides a good scalability of the algorithm. Numerical results show the efficiency of the parareal method on large light water reactor transient model corresponding to the Langenbuch–Maurer–Werner benchmark.

Global solutions to random 3D vorticity equations for small initial data

Science.gov (United States)

Barbu, Viorel; Röckner, Michael

2017-11-01

One proves the existence and uniqueness in (Lp (R3)) 3, 3/2 4p - 6)3 with respect to the time variable. Furthermore, we obtain the pathwise continuous dependence of solutions with respect to the initial data. In particular, one gets a locally unique solution of 3D stochastic Navier-Stokes equation in vorticity form up to some explosion stopping time τ adapted to the Brownian motion.

RAG-3D: a search tool for RNA 3D substructures

Science.gov (United States)

Zahran, Mai; Sevim Bayrak, Cigdem; Elmetwaly, Shereef; Schlick, Tamar

2015-01-01

To address many challenges in RNA structure/function prediction, the characterization of RNA's modular architectural units is required. Using the RNA-As-Graphs (RAG) database, we have previously explored the existence of secondary structure (2D) submotifs within larger RNA structures. Here we present RAG-3D—a dataset of RNA tertiary (3D) structures and substructures plus a web-based search tool—designed to exploit graph representations of RNAs for the goal of searching for similar 3D structural fragments. The objects in RAG-3D consist of 3D structures translated into 3D graphs, cataloged based on the connectivity between their secondary structure elements. Each graph is additionally described in terms of its subgraph building blocks. The RAG-3D search tool then compares a query RNA 3D structure to those in the database to obtain structurally similar structures and substructures. This comparison reveals conserved 3D RNA features and thus may suggest functional connections. Though RNA search programs based on similarity in sequence, 2D, and/or 3D structural elements are available, our graph-based search tool may be advantageous for illuminating similarities that are not obvious; using motifs rather than sequence space also reduces search times considerably. Ultimately, such substructuring could be useful for RNA 3D structure prediction, structure/function inference and inverse folding. PMID:26304547

Time-dependent inhibition of CYP3A4 by gallic acid in human liver microsomes and recombinant systems.

Science.gov (United States)

Pu, Qiang-Hong; Shi, Liang; Yu, Chao

2015-03-01

1.Gallic acid is a main polyphenol in various fruits and plants. Inhibitory characteristics of gallic acid on CYP3A4 were still unclear. The objective of this work is hence to investigate inhibitory characteristics of gallic acid on CYP3A4 using testosterone as the probe substrate in human liver microsomes (HLMs) and recombinant CYP3A4 (rCYP3A4) systems. 2.Gallic acid caused concentration-dependent loss of CYP3A4 activity with IC50 values of 615.2 μM and 669.5 μM in HLM and rCYP3A4 systems, respectively. IC50-shift experiments showed that pre-incubation with gallic acid in the absence of NADPH contributed to 12- or 14-fold reduction of IC50 in HLM and rCYP3A4 systems, respectively, supporting a time-dependent inhibition. In HLM, time-dependent inactivation variables KI and Kinact were 485.8 μM and 0.05 min(-1), respectively. 3.Compared with the presence of NADPH, pre-incubation of gallic acid in the absence of NADPH markedly increased its inhibitory effects in HLM and rCYP3A4 systems. Those results indicate that CYP3A4 inactivation by gallic acid was independent on NADPH and was mainly mediated its oxidative products. 4.In conclusion, we showed that gallic acid weakly and time-dependently inactivated CYP3A4 via its oxidative products.

Highly-stretchable 3D-architected Mechanical Metamaterials

Science.gov (United States)

Jiang, Yanhui; Wang, Qiming

2016-09-01

Soft materials featuring both 3D free-form architectures and high stretchability are highly desirable for a number of engineering applications ranging from cushion modulators, soft robots to stretchable electronics; however, both the manufacturing and fundamental mechanics are largely elusive. Here, we overcome the manufacturing difficulties and report a class of mechanical metamaterials that not only features 3D free-form lattice architectures but also poses ultrahigh reversible stretchability (strain > 414%), 4 times higher than that of the existing counterparts with the similar complexity of 3D architectures. The microarchitected metamaterials, made of highly stretchable elastomers, are realized through an additive manufacturing technique, projection microstereolithography, and its postprocessing. With the fabricated metamaterials, we reveal their exotic mechanical behaviors: Under large-strain tension, their moduli follow a linear scaling relationship with their densities regardless of architecture types, in sharp contrast to the architecture-dependent modulus power-law of the existing engineering materials; under large-strain compression, they present tunable negative-stiffness that enables ultrahigh energy absorption efficiencies. To harness their extraordinary stretchability and microstructures, we demonstrate that the metamaterials open a number of application avenues in lightweight and flexible structure connectors, ultraefficient dampers, 3D meshed rehabilitation structures and stretchable electronics with designed 3D anisotropic conductivity.

Multitasking the code ARC3D. [for computational fluid dynamics

Science.gov (United States)

Barton, John T.; Hsiung, Christopher C.

1986-01-01

The CRAY multitasking system was developed in order to utilize all four processors and sharply reduce the wall clock run time. This paper describes the techniques used to modify the computational fluid dynamics code ARC3D for this run and analyzes the achieved speedup. The ARC3D code solves either the Euler or thin-layer N-S equations using an implicit approximate factorization scheme. Results indicate that multitask processing can be used to achieve wall clock speedup factors of over three times, depending on the nature of the program code being used. Multitasking appears to be particularly advantageous for large-memory problems running on multiple CPU computers.

[Effect of 3D printing technology on pelvic fractures:a Meta-analysis].

Science.gov (United States)

Zhang, Yu-Dong; Wu, Ren-Yuan; Xie, Ding-Ding; Zhang, Lei; He, Yi; Zhang, Hong

2018-05-25

To evaluate the effect of 3D printing technology applied in the surgical treatment of pelvic fractures through the published literatures by Meta-analysis. The PubMed database, EMCC database, CBM database, CNKI database, VIP database and Wanfang database were searched from the date of database foundation to August 2017 to collect the controlled clinical trials in wich 3D printing technology was applied in preoperative planning of pelvic fracture surgery. The retrieved literatures were screened according to predefined inclusion and exclusion criteria, and quality evaluation were performed. Then, the available data were extracted and analyzed with the RevMan5.3 software. Totally 9 controlled clinical trials including 638 cases were chosen. Among them, 279 cases were assigned to the 3D printing technology group and 359 cases to the conventional group. The Meta-analysis results showed that the operative time[SMD=-2.81, 95%CI(-3.76, -1.85)], intraoperative blood loss[SMD=-3.28, 95%CI(-4.72, -1.85)] and the rate of complication [OR=0.47, 95%CI(0.25, 0.87)] in the 3D printing technology were all lower than those in the conventional group;the excellent and good rate of pelvic fracture reduction[OR=2.09, 95%CI(1.32, 3.30)] and postoperative pelvic functional restoration [OR=1.94, 95%CI(1.15, 3.28) in the 3D printing technology were all superior to those in the conventional group. 3D printing technology applied in the surgical treatment of pelvic fractures has the advantage of shorter operative time, less intraoperative blood loss and lower rate of complication, and can improve the quality of pelvic fracture reduction and the recovery of postoperative pelvic function. Copyright© 2018 by the China Journal of Orthopaedics and Traumatology Press.

SCRAM reactivity calculations with the KIKO3D code

International Nuclear Information System (INIS)

Hordosy, G.; Kerszturi, A.; Maraczy, Cs.; Temesvari, E.

1999-01-01

Discrepancies between calculated static reactivities and measured reactivities evaluated with reactivity meters led to investigating SCRAM with the KIKO3D dynamic code, The time and space dependent neutron flux in the reactor core during the rod drop measurement was calculated by the KIKO3D nodal diffusion code. For calculating the ionisation chamber signals the Green function technique was applied. The Green functions of ionisation chambers were evaluated via solving the neutron transport equation in the reflector regions with the MCNP Monte Carlo code. The detector signals during asymmetric SCRAM measurements were calculated and compared with measured data using the inverse point kinetics transformation. The sufficient agreement validates the KIKO3D code to determine the reactivities after SCRAM. (Authors)

General time-dependent formulation of quantum scattering theory

International Nuclear Information System (INIS)

Althorpe, Stuart C.

2004-01-01

We derive and explain the key ideas behind a time-dependent formulation of quantum scattering theory, applicable generally to systems with a finite-range scattering potential. The scattering is initiated and probed by plane wave packets, which are localized just outside the range of the potential. The asymptotic limits of conventional scattering theory (initiation in the remote past; detection in the remote future) are not taken. Instead, the differential cross section (DCS) is obtained by projecting the scattered wave packet onto the probe plane wave packets. The projection also yields a time-dependent version of the DCS. Cuts through the wave packet, just as it exits the scattering potential, yield time-dependent and time-independent angular distributions that give a close-up picture of the scattering which complements the DCS. We have previously applied the theory to interpret experimental cross sections of chemical reactions [e.g., S. C. Althorpe, F. Fernandez-Alonso, B. D. Bean, J. D. Ayers, A. E. Pomerantz, R. N. Zare, and E. Wrede, Nature (London) 416, 67 (2002)]. This paper gives the derivation of the theory, and explains its relation to conventional scattering theory. For clarity, the derivation is restricted to spherical-particle scattering, though it may readily be extended to general multichannel systems. We illustrate the theory using a simple application to hard-sphere scattering

Time-Dependent Liquid Transport on a Biomimetic Topological Surface.

Science.gov (United States)

Yu, Cunlong; Li, Chuxin; Gao, Can; Dong, Zhichao; Wu, Lei; Jiang, Lei

2018-05-02

Liquid drops impacting on a solid surface is a familiar phenomenon. On rainy days, it is quite important for leaves to drain off impacting raindrops. Water can bounce off or flow down a water-repellent leaf easily, but with difficulty on a hydrophilic leaf. Here, we show an interesting phenomenon in which impacting drops on the hydrophilic pitcher rim of Nepenthes alata can spread outward to prohibit water filling the pitcher tank. We mimic the peristome surface through a designed 3D printing and replicating way and report a time-dependently switchable liquid transport based on biomimetic topological structures, where surface curvature can work synergistically with the surface microtextures to manipulate the switchable spreading performance. Motived by this strange behavior, we construct a large-scaled peristome-mimetic surface in a 3D profile, demonstrating the ability to reduce the need to mop or to squeegee drops that form during the drop impacting process on pipes or other curved surfaces in food processing, moisture transfer, heat management, etc.

Finite-element-method (FEM model generation of time-resolved 3D echocardiographic geometry data for mitral-valve volumetry

Directory of Open Access Journals (Sweden)

Kikinis Ron

2006-03-01

Full Text Available Abstract Introduction Mitral Valve (MV 3D structural data can be easily obtained using standard transesophageal echocardiography (TEE devices but quantitative pre- and intraoperative volume analysis of the MV is presently not feasible in the cardiac operation room (OR. Finite element method (FEM modelling is necessary to carry out precise and individual volume analysis and in the future will form the basis for simulation of cardiac interventions. Method With the present retrospective pilot study we describe a method to transfer MV geometric data to 3D Slicer 2 software, an open-source medical visualization and analysis software package. A newly developed software program (ROIExtract allowed selection of a region-of-interest (ROI from the TEE data and data transformation for use in 3D Slicer. FEM models for quantitative volumetric studies were generated. Results ROI selection permitted the visualization and calculations required to create a sequence of volume rendered models of the MV allowing time-based visualization of regional deformation. Quantitation of tissue volume, especially important in myxomatous degeneration can be carried out. Rendered volumes are shown in 3D as well as in time-resolved 4D animations. Conclusion The visualization of the segmented MV may significantly enhance clinical interpretation. This method provides an infrastructure for the study of image guided assessment of clinical findings and surgical planning. For complete pre- and intraoperative 3D MV FEM analysis, three input elements are necessary: 1. time-gated, reality-based structural information, 2. continuous MV pressure and 3. instantaneous tissue elastance. The present process makes the first of these elements available. Volume defect analysis is essential to fully understand functional and geometrical dysfunction of but not limited to the valve. 3D Slicer was used for semi-automatic valve border detection and volume-rendering of clinical 3D echocardiographic

Learning dictionaries of sparse codes of 3D movements of body joints for real-time human activity understanding.

Science.gov (United States)

Qi, Jin; Yang, Zhiyong

2014-01-01

Real-time human activity recognition is essential for human-robot interactions for assisted healthy independent living. Most previous work in this area is performed on traditional two-dimensional (2D) videos and both global and local methods have been used. Since 2D videos are sensitive to changes of lighting condition, view angle, and scale, researchers begun to explore applications of 3D information in human activity understanding in recently years. Unfortunately, features that work well on 2D videos usually don't perform well on 3D videos and there is no consensus on what 3D features should be used. Here we propose a model of human activity recognition based on 3D movements of body joints. Our method has three steps, learning dictionaries of sparse codes of 3D movements of joints, sparse coding, and classification. In the first step, space-time volumes of 3D movements of body joints are obtained via dense sampling and independent component analysis is then performed to construct a dictionary of sparse codes for each activity. In the second step, the space-time volumes are projected to the dictionaries and a set of sparse histograms of the projection coefficients are constructed as feature representations of the activities. Finally, the sparse histograms are used as inputs to a support vector machine to recognize human activities. We tested this model on three databases of human activities and found that it outperforms the state-of-the-art algorithms. Thus, this model can be used for real-time human activity recognition in many applications.

Learning dictionaries of sparse codes of 3D movements of body joints for real-time human activity understanding.

Directory of Open Access Journals (Sweden)

Jin Qi

Full Text Available Real-time human activity recognition is essential for human-robot interactions for assisted healthy independent living. Most previous work in this area is performed on traditional two-dimensional (2D videos and both global and local methods have been used. Since 2D videos are sensitive to changes of lighting condition, view angle, and scale, researchers begun to explore applications of 3D information in human activity understanding in recently years. Unfortunately, features that work well on 2D videos usually don't perform well on 3D videos and there is no consensus on what 3D features should be used. Here we propose a model of human activity recognition based on 3D movements of body joints. Our method has three steps, learning dictionaries of sparse codes of 3D movements of joints, sparse coding, and classification. In the first step, space-time volumes of 3D movements of body joints are obtained via dense sampling and independent component analysis is then performed to construct a dictionary of sparse codes for each activity. In the second step, the space-time volumes are projected to the dictionaries and a set of sparse histograms of the projection coefficients are constructed as feature representations of the activities. Finally, the sparse histograms are used as inputs to a support vector machine to recognize human activities. We tested this model on three databases of human activities and found that it outperforms the state-of-the-art algorithms. Thus, this model can be used for real-time human activity recognition in many applications.

3D Multi‐source Least‐squares Reverse Time Migration

KAUST Repository

Dai, Wei

2010-10-17

We present the theory and numerical results for least‐squares reverse time migration (LSRTM) of phase‐encoded supergathers, where each supergather is the superposition of phased‐encoded shots. Three type of encoding functions are used in this study: random time shift, random source polarity and random source location selected from a pre‐designed table. Numerical tests for the 3D SEG/EAGE Overthrust model show that multi‐source LSRTM can suppress migration artifacts in the migration image and remove most of the crosstalk noise from multi‐source data. Empirical results suggest that multi‐source LSRTM can provide a noticeable increase in computational efficiency compared to standard RTM, when the CSGs in a supergather are modeled and migrated together with a finite‐difference simulator. If the phase‐encoding functions are dynamically changed after each iteration of LSRTM, the best images are obtained. The potential drawback is that the final results are very sensitive to the accuracy of the starting model.

Analysis of the spectrum six times ionized zinc (Zn VII): the 3d6-3d54p transition array

International Nuclear Information System (INIS)

Hof, G.H. van het; Joshi, Y.N.; Raassen, A.J.J.; Ryabtsev, A.N.

1993-01-01

The spectrum of zinc was photographed in the 100-300 A region on a 10.7 m grazing incidence spectrograph using a triggered spark light source. 335 lines were classified in the Zn VII 3d 6 -3d 5 4p transition array, resulting in the establishment of 30 of the 34 levels of the 3d 6 configuration and 103 of the 214 levels of the 3d 5 4p. The ground configuration 3d 6 was described by a generalized least-squares fit (GLSF) involving orthogonal operators to a set of 3d N configurations. This yielded a mean error of 3 cm -1 for its level values. The excited configruation was described by the conventional Slater Condon parameter set, giving a mean error of 105 cm -1 . (orig.)

New sparse matrix solver in the KIKO3D 3-dimensional reactor dynamics code

International Nuclear Information System (INIS)

Panka, I.; Kereszturi, A.; Hegedus, C.

2005-01-01

The goal of this paper is to present a more effective method Bi-CGSTAB for accelerating the large sparse matrix equation solution in the KIKO3D code. This equation system is obtained by using the factorization of the improved quasi static (IQS) method for the time dependent nodal kinetic equations. In the old methodology standard large sparse matrix techniques were considered, where Gauss-Seidel preconditioning and a GMRES-type solver were applied. The validation of KIKO3D using Bi-CGSTAB has been performed by solving of a VVER-1000 kinetic benchmark problem. Additionally, the convergence characteristics were investigated in given macro time steps of Control Rod Ejection transients. The results have been obtained by the old GMRES and new Bi-CGSTAB methods are compared. (author)

Time dependent solutions of the Fokker-Planck equation for fast fusion ions

International Nuclear Information System (INIS)

Gnavi, G.; Gratton, F.T.; Heyn, M.

1990-01-01

Approximate time dependent solutions for the Fokker-Planck equation for fast fusion ions from an isotropic, monoenergetic source are presented, for the problem of D - T - He 3 reactions. The equations include the effect of diffusion, which is particularly noticeable in the distribution of particles of lower energy and in the formation of a tail of particles with energy higher than that of the source. (Author)

Analysis of the 3d9ns (n = 5, 6), 3d95p, 3d94f and 3d84s4p configurations of five times ionized arsenic (As VI)

International Nuclear Information System (INIS)

Ryabtsev, A.N.; Gayasov, R.R.; Joshi, Y.N.; Van het Hof, G.J.

1993-01-01

The spectrum of arsenic was photographed in the 100-1250 A region on grazing and normal incidence spectrographs. The spectrum of As VI was extended. Seven out of eight levels of the 3d 9 5s and 6s configurations, 12 out of 12 levels of the 3d 9 5p configuration, 13 out of 20 levels of the 3d 9 4f configuration and 35 levels belonging to the 3d 9 4s4p configuration have been established. Least-Square-Fitted parametric calculations involving configuration interactions both in even and odd parity systems were carried out to adequately interpret the spectrum. One hundred and thirty-two additional lines were classified in the As VI spectrum. A new value of the ionization limit was obtained. Thus, the 3d 9 2 D 5/2 ground level in As VII lies 977500 cm -1 (121.17 eV) above the As VI ground state. (orig.)