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Sample records for timm tnu mls

  1. Darkfield illumination improves microscopic detection of metals in Timm's stained tissue

    DEFF Research Database (Denmark)

    Baatrup, E; Frederickson, C J

    1989-01-01

    Deposits of trace or toxic metals can be quickly identified by light microscopical surveys of tissue sections stained for metals by variants of Timm's silver enhancement method. The present work shows that the small, isolated silver grains that label isolated deposits of metal in tissue are undet...... are undetectable in brightfield light microscopy but are easily detected in darkfield microscopy. Darkfield illumination is therefore recommended for improving the detection of trace or toxic metals in tissue. Udgivelsesdato: 1989-Aug......Deposits of trace or toxic metals can be quickly identified by light microscopical surveys of tissue sections stained for metals by variants of Timm's silver enhancement method. The present work shows that the small, isolated silver grains that label isolated deposits of metal in tissue...

  2. Specification and design of a Therapy Imaging and Model Management System (TIMMS)

    Science.gov (United States)

    Lemke, Heinz U.; Berliner, Leonard

    2007-03-01

    Appropriate use of Information and Communication Technology (ICT) and Mechatronic (MT) systems is considered by many experts as a significant contribution to improve workflow and quality of care in the Operating Room (OR). This will require a suitable IT infrastructure as well as communication and interface standards, such as DICOM and suitable extensions, to allow data interchange between surgical system components in the OR. A conceptual design of such an infrastructure, i.e. a Therapy Imaging and Model Management System (TIMMS) will be introduced in this paper. A TIMMS should support the essential functions that enable and advance image, and in particular, patient model guided therapy. Within this concept, the image centric world view of the classical PACS technology is complemented by an IT model-centric world view. Such a view is founded in the special modelling needs of an increasing number of modern surgical interventions as compared to the imaging intensive working mode of diagnostic radiology, for which PACS was originally conceptualised and developed. A proper design of a TIMMS, taking into account modern software engineering principles, such as service oriented architecture, will clarify the right position of interfaces and relevant standards for a Surgical Assist System (SAS) in general and their components specifically. Such a system needs to be designed to provide a highly modular structure. Modules may be defined on different granulation levels. A first list of components (e.g. high and low level modules) comprising engines and repositories of an SAS, which should be integrated by a TIMMS, will be introduced in this paper.

  3. PACS for surgery and interventional radiology: Features of a Therapy Imaging and Model Management System (TIMMS)

    International Nuclear Information System (INIS)

    Lemke, Heinz U.; Berliner, Leonard

    2011-01-01

    Appropriate use of information and communication technology (ICT) and mechatronic (MT) systems is viewed by many experts as a means to improve workflow and quality of care in the operating room (OR). This will require a suitable information technology (IT) infrastructure, as well as communication and interface standards, such as specialized extensions of DICOM, to allow data interchange between surgical system components in the OR. A design of such an infrastructure, sometimes referred to as surgical PACS, but better defined as a Therapy Imaging and Model Management System (TIMMS), will be introduced in this article. A TIMMS should support the essential functions that enable and advance image guided therapy, and in the future, a more comprehensive form of patient-model guided therapy. Within this concept, the 'image-centric world view' of the classical PACS technology is complemented by an IT 'model-centric world view'. Such a view is founded in the special patient modelling needs of an increasing number of modern surgical interventions as compared to the imaging intensive working mode of diagnostic radiology, for which PACS was originally conceptualised and developed. The modelling aspects refer to both patient information and workflow modelling. Standards for creating and integrating information about patients, equipment, and procedures are vitally needed when planning for an efficient OR. The DICOM Working Group 24 (WG-24) has been established to develop DICOM objects and services related to image and model guided surgery. To determine these standards, it is important to define step-by-step surgical workflow practices and create interventional workflow models per procedures or per variable cases. As the boundaries between radiation therapy, surgery and interventional radiology are becoming less well-defined, precise patient models will become the greatest common denominator for all therapeutic disciplines. In addition to imaging, the focus of WG-24 is to serve

  4. Uwe Timms Berliner Trilogie Bilanzen von Teilung und Wende in Johannisnacht, Rot und Halbschatten

    Directory of Open Access Journals (Sweden)

    Ana Helena Krause

    2009-06-01

    Full Text Available Uwe Timm tematiza a divisão da Alemanha e o processo de reunificação em sua “Trilogia de Berlim”, com os romances Johannisnacht (1996, Rot (2001 e Halbschatten (2008. Nos dois primeiros, as lembranças e experiências narradas pelas personagens oferecem um panorama heterogêneo do período pós-Segunda Guerra Mundial no leste e no oeste do país: Johannisnacht apresenta o caos da cidade em 1995 e a dificuldade de comunicação entre “Ossis” e “Wessis”, enquanto em Rot, o fracasso da experiência socialista é parte das desilusões dos velhos ativistas do Movimento Estudantil. Por sua vez, em Halbschatten, o autor focaliza a história alemã antes de 1945, buscando no passado militarista da Prússia as causas do cenário presente nos dois romances anteriores. O Cemitério dos Inválidos, o mais antigo da cidade, aparece como palco de eventos históricos e memória concretamente visível: além de unir a elite militar prussiana e membros do alto comando nazistas a lutadores da resistência anti-hitleriana, ele foi dividido ao meio pelo Muro de Berlim.

  5. Assimilation of MLS and OMI Ozone Data

    Science.gov (United States)

    Stajner, I.; Wargan, K.; Chang, L.-P.; Hayashi, H.; Pawson, S.; Froidevaux, L.; Livesey, N.

    2005-01-01

    Ozone data from Aura Microwave Limb Sounder (MLS) and Ozone Monitoring Instrument (OMI) were assimilated into the ozone model at NASA's Global Modeling and Assimilation Office (GMAO). This assimilation produces ozone fields that are superior to those from the operational GMAO assimilation of Solar Backscatter Ultraviolet (SBUV/2) instrument data. Assimilation of Aura data improves the representation of the "ozone hole" and the agreement with independent Stratospheric Aerosol and Gas Experiment (SAGE) III and ozone sonde data. Ozone in the lower stratosphere is captured better: mean state, vertical gradients, spatial and temporal variability are all improved. Inclusion of OMI and MLS data together, or separately, in the assimilation system provides a way of checking how consistent OMI and MLS data are with each other, and with the ozone model. We found that differences between OMI total ozone column data and model forecasts decrease after MLS data are assimilated. This indicates that MLS stratospheric ozone profiles are consistent with OMI total ozone columns. The evaluation of error characteristics of OMI and MLS ozone will continue as data from newer versions of retrievals becomes available. We report on the initial step in obtaining global assimilated ozone fields that combine measurements from different Aura instruments, the ozone model at the GMAO, and their respective error characteristics. We plan to use assimilated ozone fields in estimation of tropospheric ozone. We also plan to investigate impacts of assimilated ozone fields on numerical weather prediction through their use in radiative models and in the assimilation of infrared nadir radiance data from NASA's Advanced Infrared Sounder (AIRS).

  6. A Strategy for an MLS Workflow Management System

    National Research Council Canada - National Science Library

    Kang, Myong H; Froscher, Judith N; Eppinger, Brian J; Moskowitz, Ira S

    1999-01-01

    .... Therefore, DoD needs MLS workflow management systems (WFMS) to enable globally distributed users and existing applications to cooperate across classification domains to achieve mission critical goals...

  7. Detection of Persons in Mls Point Clouds

    Science.gov (United States)

    Borgmann, B.; Hebel, M.; Arens, M.; Stilla, U.

    2017-09-01

    In this paper we present an approach for the detection of persons in point clouds gathered by mobile laser scanning (MLS) systems. The approach consists of a preprocessing and the actual detection. The main task of the preprocessing is to reduce the amount of data which has to be processed by the detection. To fulfill this task, the preprocessing consists of ground removal, segmentation and several filters. The detection is based on an implicit shape models (ISM) approach which is an extension to bag-of-words approaches. For this detection method, it is sufficient to work with a small amount of training data. Although in this paper we focus on the detection of persons, our approach is able to detect multiple classes of objects in point clouds. Using a parameterization of the approach which offers a good compromise between detection and runtime performance, we are able to achieve a precision of 0.68 and a recall of 0.76 while having a average runtime of 370 ms per single scan rotation of the rotating head of a typical MLS sensor.

  8. Time variance effects and measurement error indications for MLS measurements

    DEFF Research Database (Denmark)

    Liu, Jiyuan

    1999-01-01

    Mathematical characteristics of Maximum-Length-Sequences are discussed, and effects of measuring on slightly time-varying systems with the MLS method are examined with computer simulations with MATLAB. A new coherence measure is suggested for the indication of time-variance effects. The results...... of the simulations show that the proposed MLS coherence can give an indication of time-variance effects....

  9. Sulfide silver architectonics of rat, cat, and guinea pig spinal cord. A light microscopic study with Timm's method for demonstration of heavy metals

    DEFF Research Database (Denmark)

    Schroder, H D

    1977-01-01

    The distribution of heavy metals in the spinal cord of the cat, rat, and guinea pig has been studied histochemically with Timm's sulfide silver method. There was considerable variation in the degree of staining of the neuropil. The dorsal horn showed a laminar staining pattern corresponding......, characterized by heterogeneous staining, also appeared dark, although less obvious in the guinea pig. In the ventral horn the coarser stained particles in lamina IX contrasted with the surrounding lamina. Cell staining varied between different cell groups, and within single cell populations. In the cat thoracic...... cord the cells in nucleus intermedio-lateralis (IL) and nucleus intercalatus (IC) stained very weakly. In Clarke's column and in the motoneuron area cells, uniform in Nissl preparations, could be seen different after Timm staining. The results are discussed in relation to other histochemical patterns...

  10. MLS/Aura Level 2 Temperature V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2T is the EOS Aura Microwave Limb Sounder (MLS) standard product for temperature derived from radiances measured by the 118 and 240 GHz radiometers. The current...

  11. UARS Microwave Limb Sounder (MLS) Level 3AT V001

    Data.gov (United States)

    National Aeronautics and Space Administration — The Microwave Limb Sounder (MLS) Level 3AT data product consists of daily, 65.536 second interval time-ordered vertical profiles of temperature, geopotential height,...

  12. UARS Microwave Limb Sounder (MLS) Level 3AL V001

    Data.gov (United States)

    National Aeronautics and Space Administration — The Microwave Limb Sounder (MLS) Level 3AL data product consists of daily, 4 degree increment latitude-ordered vertical profiles of temperature, geopotential height,...

  13. MLS/Aura L2 Geopotential Height V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2GPH is the EOS Aura Microwave Limb Sounder (MLS) standard product for geopotential height derived from radiances measured by the 118 and 240 GHz radiometers. The...

  14. MLS/Aura L2 Geopotential Height V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2GPH is the EOS Aura Microwave Limb Sounder (MLS) standard product for geopotential height derived from radiances measured by the 118 and 240 GHz radiometers. The...

  15. MLS/Aura Level 2 Diagnostics, Miscellaneous Grid V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2DGM is the EOS Aura Microwave Limb Sounder (MLS) product containing the minor frame diagnostic quantities on a miscellaneous grid. These include items such as...

  16. MLS/Aura L2 Diagnostics, Miscellaneous Grid V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2DGM is the EOS Aura Microwave Limb Sounder (MLS) product containing the minor frame diagnostic quantities on a miscellaneous grid. These include items such as...

  17. MLS/Aura L2 Temperature V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2T is the EOS Aura Microwave Limb Sounder (MLS) standard product for temperature derived from radiances measured by the 118 and 240 GHz radiometers. The current...

  18. TES/MLS Aura L2 CO V001

    Data.gov (United States)

    National Aeronautics and Space Administration — TES TML2CO Global Survey Standard Products are derived from TES (Tropospheric Emission Spectrometer) nadir and MLS (Microwave Limb Sounder) limb measurements from...

  19. MLS/Aura L2 Diagnostics, Miscellaneous Grid V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2DGM is the EOS Aura Microwave Limb Sounder (MLS) product containing the minor frame diagnostic quantities on a miscellaneous grid. These include items such as...

  20. MLS/Aura L2 Temperature V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2T is the EOS Aura Microwave Limb Sounder (MLS) standard product for temperature derived from radiances measured by the 118 and 240 GHz radiometers. The current...

  1. MLS/Aura L2 Cloud Ice Product V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2IWC is the EOS Aura Microwave Limb Sounder (MLS) standard product for cloud ice water content derived from radiances measured by the 240 GHz radiometer. The...

  2. MLS/Aura Level 2 Cloud Ice Product V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2IWC is the EOS Aura Microwave Limb Sounder (MLS) standard product for cloud ice water content derived from radiances measured by the 240 GHz radiometer. The...

  3. MLS/Aura L2 Cloud Ice Product V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2IWC is the EOS Aura Microwave Limb Sounder (MLS) standard product for cloud ice water content derived from radiances measured by the 240 GHz radiometer. The...

  4. MLS/Aura Level 2 Geopotential Height V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2GPH is the EOS Aura Microwave Limb Sounder (MLS) standard product for geopotential height derived from radiances measured by the 118 and 240 GHz radiometers. The...

  5. Aqua AIRS-MLS Matchup Indexes V1.0 (AIRS_MLS_IND) at GES_DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — This dataset is part of MEaSUREs 2012 Program, and represent Aqua/AIRS-Aura/MLS collocation indexes, in netCDF-4 format. These data map AIRS profile indexes to those...

  6. Equatorial Kelvin waves: A UARS MLS view

    Science.gov (United States)

    Canziani, Pablo O.; Holton, James R.; Fishbein, Evan; Froidevaux, Lucien; Waters, Joe W.

    1994-01-01

    Data from the Microwave Limb Sounder (MLS) instrument on the Upper Atmosphere Research Satellite (UARS) are used to compare two periods of Kelvin wave activity during different stages of the equatorial quasi-biennial oscillation. The analysis is carried out using an asynoptic mapping technique. A wide bandpass filter is used to isolate the frequency bands where Kelvin waves have been identified in previous studies. Time-height and time-latitude plots of the bandpassed data are used to identify Kelvin wave activity in the temperature and ozone fields. Frequency spectra of temperature and ozone amplitudes are constructed to further analyze the latitudinal and meridional distribution of Kelvin wave activity in zonal wavenumbers 1 and 2. The characteristics identified in these plots agree well with theoretical predictions and previous observations of middle atmosphere Kelvin waves. The time-height and time-latitude plots support the existence of Kelvin waves in discrete frequency bands; the slow, fast, and ultrafast Kelvin modes are all identified in the data. The characteristics of these modes do not vary much despite different mean flow conditions in the two periods examined. For the Kelvin wave-induced perturbations in ozone, the change from a transport-dominated regime below 10 hPa to a photochemically controlled regime above 10 hPa is clearly apparent in the height dependence of the phase difference between temperature and ozone. The ratios of the ozone perturbation amplitude to the temperature perturbation amplitude for the various observed Kelvin wave modes are in agreement with model estimates and LIMS (Limb Infrared Monitor of the Stratosphere) observations in the lower half of the region sampled but appear to be too large in the upper stratosphere and lower mesosphere.

  7. Observations of volcanic SO2 from MLS on Aura

    Directory of Open Access Journals (Sweden)

    H. C. Pumphrey

    2015-01-01

    Full Text Available Sulfur dioxide (SO2 is an important atmospheric constituent, particularly in the aftermath of volcanic eruptions. These events can inject large amounts of SO2 into the lower stratosphere, where it is oxidised to form sulfate aerosols; these in turn have a significant effect on the climate. The MLS instrument on the Aura satellite has observed the SO2 mixing ratio in the upper troposphere and lower stratosphere from August 2004 to the present, during which time a number of volcanic eruptions have significantly affected those regions of the atmosphere. We describe the MLS SO2 data and how various volcanic events appear in the data. As the MLS SO2 data are currently not validated we take some initial steps towards their validation. First we establish the level of internal consistency between the three spectral regions in which MLS is sensitive to SO2. We compare SO2 column values calculated from MLS data to total column values reported by the OMI instrument. The agreement is good (within about 1 DU in cases where the SO2 is clearly at altitudes above 147 hPa.

  8. Kataloonia muusikaelust / Tõnu Timm

    Index Scriptorium Estoniae

    Timm, Tõnu, 1964-

    2008-01-01

    Ülevaade Kataloonia muusikakultuurist algusaegadest kuni tänapäevani. Artikli lõpus kolm kuulamissoovitust: El Pont D'Arcalis "Aigua, mes aigua!", Rosa Zaragoza - "Terra de jueus" ja Orchestra Arab de Barcelona "Baraka"

  9. Calamagrostis stricta (Timm) Koeler

    Czech Academy of Sciences Publication Activity Database

    Ekrt, L.; Štech, M.; Kaplan, Zdeněk

    2014-01-01

    Roč. 49, č. 1 (2014), s. 92-93 ISSN 1211-5258 R&D Projects: GA ČR GB14-36079G Institutional support: RVO:67985939 Keywords : floristics * distribution * endangered species Subject RIV: EF - Botanics

  10. Educational Requirements beyond the MLS for Academic Librarians in 1990.

    Science.gov (United States)

    Aufderhaar, Kathleen E.

    Eight-hundred sixty-five advertisements for academic librarian positions in the 1990 issues of "American Libraries" were examined to determine how many position advertisements were asking for advanced degrees in addition to the MLS. Data from the 231 advertisements asking for advanced degrees were compared with data from previous studies as well…

  11. MLS student active learning within a "cloud" technology program.

    Science.gov (United States)

    Tille, Patricia M; Hall, Heather

    2011-01-01

    In November 2009, the MLS program in a large public university serving a geographically large, sparsely populated state instituted an initiative for the integration of technology enhanced teaching and learning within the curriculum. This paper is intended to provide an introduction to the system requirements and sample instructional exercises used to create an active learning technology-based classroom. Discussion includes the following: 1.) define active learning and the essential components, 2.) summarize teaching methods, technology and exercises utilized within a "cloud" technology program, 3.) describe a "cloud" enhanced classroom and programming 4.) identify active learning tools and exercises that can be implemented into laboratory science programs, and 5.) describe the evaluation and assessment of curriculum changes and student outcomes. The integration of technology in the MLS program is a continual process and is intended to provide student-driven active learning experiences.

  12. Interannual Variations of MLS Carbon Monoxide Induced by Solar Cycle

    Science.gov (United States)

    Lee, Jae N.; Wu, Dong L.; Ruzmaikin, Alexander

    2013-01-01

    More than eight years (2004-2012) of carbon monoxide (CO) measurements from the Aura Microwave Limb Sounder (MLS) are analyzed. The mesospheric CO, largely produced by the carbon dioxide (CO2) photolysis in the lower thermosphere, is sensitive to the solar irradiance variability. The long-term variation of observed mesospheric MLS CO concentrations at high latitudes is likely driven by the solar-cycle modulated UV forcing. Despite of different CO abundances in the southern and northern hemispheric winter, the solar-cycle dependence appears to be similar. This solar signal is further carried down to the lower altitudes by the dynamical descent in the winter polar vortex. Aura MLS CO is compared with the Solar Radiation and Climate Experiment (SORCE) total solar irradiance (TSI) and also with the spectral irradiance in the far ultraviolet (FUV) region from the SORCE Solar-Stellar Irradiance Comparison Experiment (SOLSTICE). Significant positive correlation (up to 0.6) is found between CO and FUVTSI in a large part of the upper atmosphere. The distribution of this positive correlation in the mesosphere is consistent with the expectation of CO changes induced by the solar irradiance variations.

  13. Software safety analysis activities during software development phases of the Microwave Limb Sounder (MLS)

    Science.gov (United States)

    Shaw, Hui-Yin; Sherif, Joseph S.

    2004-01-01

    This paper describes the MLS software safety analysis activities and documents the SSA results. The scope of this software safety effort is consistent with the MLS system safety definition and is concentrated on the software faults and hazards that may have impact on the personnel safety and the environment safety.

  14. Solar Cycle Variations as Observed by MLS Carbon Monoxide

    Science.gov (United States)

    Lee, J. N.; Wu, D. L.; Ruzmaikin, A.; Fontenla, J. M.

    2017-12-01

    More than thirteen years (2004-2017) of carbon monoxide (CO) measurements from the Aura Microwave Limb Sounder (MLS) are analyzed to better understand impacts of solar cycle 24. The upper mesospheric CO, produced primarily by the carbon dioxide (CO2) photolysis in the lower thermosphere, is sensitive to solar irradiance variability. We find that interannual variations of the mesospheric CO concentration are largely driven by the solar-cycle modulated ultraviolet (UV) variation in most of the UV wavelengths (120 to 280 nm) in high latitude regions. Despite different mean CO abundances in the SH and NH winters, their solar-cycle dependence appears to be symmetric with respect to the winter pole. This solar signal extends down to the lower altitudes by the dynamical descent in the polar vortex, showing a time lag that is consistent with the average descent velocity. To characterize a global distribution of the solar influence, Aura MLS CO is correlated with the Solar Radiation and Climate Experiment (SORCE) Total Irradiance Monitor (TIM) measured total solar irradiance (TSI) and with the SORCE Solar-Stellar Irradiance Comparison Experiment (SOLSTICE) measured UV. As high as 0.8 in most of the polar mesosphere, the linear correlation coefficients between CO and UV/TSI are more robust than those found in the previous work, with the extended analysis period. Different from the result shown in Lee et al. (2013), the downward propagation of the solar signals is similar in both NH and SH high latitudes. Effects of solar forcing on mesospheric CO extend far beyond the polar region. CO is a good tracer to show that the solar induced CO anomaly seems to follow the global meridional residual circulation and hemispheric transition from pole to pole in every six months. WACCM simulation experiment with two different solar spectral irradiance models, SRPM (Solar Radiation Physical Modeling) 2012 and NRLSSI (Naval Research Laboratory Spectral Solar Irradiance), shows that the

  15. Aura MLS Cloud Measurements: First-Year Results

    Science.gov (United States)

    Jiang, Jonathan H.; Wu, Dong L.

    2005-01-01

    Aura MLS provides the first vertical upper tropospheric cloud profiling from space, enabling global survey of the vertical structure of cloud systems, with seasonal and geographical variations, needed to evaluate the way clouds are parameterized in global models, thereby contributing to the understanding of cloud-climate feedbacks, and improved weather and climate predictions. The vertical structure of cloud systems is fundamentally important for understanding how clouds affect both their regional and large-scale atmospheric and radiative environments. The regional cloud profiles provide a critical tests of important parameterizations that enable the calculation of radiative flux profiles and heating rates throughout the atmospheric column, which in turn also regulates the water and energy cycles in the upper troposphere

  16. MLS/Aura Level 2 Carbon Monoxide (CO) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CO is the EOS Aura Microwave Limb Sounder (MLS) standard product for carbon monoxide derived from radiances measured by the 640 GHz radiometer. The current...

  17. MLS/Aura L1 Radiances from Filter Banks for THz V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADT is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the filter banks for the THz radiometer. The current version is...

  18. MLS/Aura L2 Nitric Acid (HNO3) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HNO3 is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitric acid derived from radiances measured by the 240 GHz radiometer at and below 10 hPa,...

  19. MLS/Aura Level 2 Nitric Acid (HNO3) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HNO3 is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitric acid derived from radiances measured by the 240 GHz radiometer at and below 10 hPa,...

  20. MLS/Aura L2 Nitric Acid (HNO3) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HNO3 is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitric acid derived from radiances measured by the 240 GHz radiometer at and below 10 hPa,...

  1. MLS/Aura Level 2 Hypochlorous Acid (HOCl) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HOCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hypochlorous acid derived from radiances measured primarily by the 640 GHz radiometer. The...

  2. MLS/Aura L2 Hypochlorous Acid (HOCL) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HOCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hypochlorous acid derived from radiances measured primarily by the 640 GHz radiometer. The...

  3. MLS/Aura L2 Nitrous Oxide (N2O) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2N2O is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitrous oxide derived from radiances measured primarily by the 640 GHz radiometer (Band 12)...

  4. MLS/Aura L2 Hydrogen Chloride (HCl) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydrogen chloride derived from radiances measured primarily by the 640 GHz radiometer. The...

  5. MLS/Aura L2 Hydroxyl (OH) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2OH is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydroxyl derived from radiances measured by the THz radiometer. The current version is 2.2....

  6. MLS/Aura Level 2 Nitrous Oxide (N2O) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2N2O is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitrous oxide derived from radiances measured primarily by the 640 GHz radiometer (Band 12)...

  7. MLS/Aura L1 Radiances from Filter Banks for GHz V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADG is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the filter banks for the GHz radiometers. The current version is...

  8. MLS/Aura L2 Diagnostics, Geophysical Parameter Grid V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2DGG is the EOS Aura Microwave Limb Sounder (MLS) product containing geophysical diagnostic quantities pertaining directly to the standard geophysical data...

  9. MLS/Aura L2 Diagnostics, Geophysical Parameter Grid V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2DGG is the EOS Aura Microwave Limb Sounder (MLS) product containing geophysical diagnostic quantities pertaining directly to the standard geophysical data...

  10. MLS/Aura L2 Relative Humidity With Respect To Ice V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2RHI is the EOS Aura Microwave Limb Sounder (MLS) standard product for relative humidity with respect to ice derived from radiances measured by the 118 and 190 GHz...

  11. MLS/Aura L1 Orbit/Attitude and Tangent Point Geolocation Data V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1OA is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 orbit attitude and tangent point geolocation data. The current version is 4.2. Data...

  12. MLS/Aura L1 Orbit/Attitude and Tangent Point Geolocation Data V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1OA is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 orbit attitude and tangent point geolocation data. The current version is 2.3. Data...

  13. MLS/Aura L1 Radiances from Filter Banks for THz V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADT is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the filter banks for the THz radiometer. The current version is...

  14. MLS/Aura Level 2 Hydroxyl (OH) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2OH is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydroxyl derived from radiances measured by the THz radiometer. The current version is 4.2....

  15. MLS/Aura L1 Radiances from Digital Autocorrelators V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADD is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the digital autocorrelators. The current version is 4.2. Data...

  16. TES/MLS Aura L2 CO Special Observation V001

    Data.gov (United States)

    National Aeronautics and Space Administration — TES TML2COS Special Observation Products are derived from TES (Tropospheric Emission Spectrometer) nadir and MLS (Microwave Limb Sounder) limb measurements from the...

  17. MLS/Aura L2 Water Vapor (H2O) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2H2O is the EOS Aura Microwave Limb Sounder (MLS) standard product for water vapor derived from radiances measured primarily by the 190 GHz radiometer. The current...

  18. MLS/Aura Level 2 Methyl Cyanide (CH3CN) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CH3CN is the EOS Aura Microwave Limb Sounder (MLS) standard product for methyl cyanide derived from radiances measured by the 640 GHz radiometer. The current...

  19. UARS Microwave Limb Sounder (MLS) Level 3AL V005 (UARML3AL) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — The Microwave Limb Sounder (MLS) Level 3AL data product consists of daily, 4 degree increment latitude-ordered vertical profiles of temperature, geopotential height,...

  20. UARS Microwave Limb Sounder (MLS) Level 3AT V005 (UARML3AT) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — The Microwave Limb Sounder (MLS) Level 3AT data product consists of daily, 4 degree increment latitude-ordered vertical profiles of temperature, geopotential height,...

  1. MLS/Aura Level 2 Hydrogen Cyanide (HCN) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HCN is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydrogen cyanide derived from radiances measured primarily by the 190 GHz radiometer. The...

  2. MLS/Aura L2 Hydrogen Chloride (HCl) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydrogen chloride derived from radiances measured primarily by the 640 GHz radiometer. The...

  3. MLS/Aura L2 Hydrogen Cyanide (HCN) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HCN is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydrogen cyanide derived from radiances measured primarily by the 190 GHz radiometer. The...

  4. MLS/Aura L2 Hydrogen Cyanide (HCN) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HCN is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydrogen cyanide derived from radiances measured primarily by the 190 GHz radiometer. The...

  5. MLS/Aura Level 2 Hydrogen Chloride (HCl) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydrogen chloride derived from radiances measured primarily by the 640 GHz radiometer. The...

  6. MLS/Aura Near-Real-Time L2 Temperature V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2T_NRT is the EOS Aura Microwave Limb Sounder (MLS) Near-Real-Time (NRT) product for temperature. This product contains daily temperature profiles taken from the...

  7. MLS/Aura L2 Sulfur Dioxide (SO2) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2SO2 is the EOS Aura Microwave Limb Sounder (MLS) standard product for sulfur dioxide derived from radiances measured by the 240 GHz radiometer. The current...

  8. HIRDLS-MLS/Aura Level 3 Ice Water Content V002

    Data.gov (United States)

    National Aeronautics and Space Administration — HIRMLS3IWC is the Joint EOS High Resolution Dynamics Limb Sounder (HIRDLS) and Microwave Limb Sounder (MLS) monthly 10 deg lat x 20 deg lon gridded product for ice...

  9. MLS/Aura L1 Radiances from Filter Banks for GHz V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADG is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the filter banks for the GHz radiometers. The current version is...

  10. MLS/Aura Near-Real-Time L2 Carbon Monoxide (CO) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CO_NRT is the EOS Aura Microwave Limb Sounder (MLS) Near-Real-Time (NRT) product for carbon monoxide (CO). This product contains daily CO profiles taken from the...

  11. MLS/Aura Level 2 Bromine Monoxide (BrO) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2BRO is the EOS Aura Microwave Limb Sounder (MLS) standard product for bromine monoxide derived from radiances measured by the 640 GHz radiometer. The current...

  12. MLS/Aura L2 Chlorine Monoxide (ClO) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CLO is the EOS Aura Microwave Limb Sounder (MLS) standard product for chlorine monoxide derived from radiances measured primarily by the 640 GHz radiometer. The...

  13. MLS/Aura Level 2 Diagnostics, Geophysical Parameter Grid V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2DGG is the EOS Aura Microwave Limb Sounder (MLS) product containing geophysical diagnostic quantities pertaining directly to the standard geophysical data...

  14. MLS/Aura L1 Radiances from Digital Autocorrelators V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADD is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the digital autocorrelators. The current version is 2.3. Data...

  15. MLS/Aura L2 Hypochlorous Acid (HOCL) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HOCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hypochlorous acid derived from radiances measured primarily by the 640 GHz radiometer. The...

  16. MLS/Aura L2 Carbon Monoxide (CO) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CO is the EOS Aura Microwave Limb Sounder (MLS) standard product for carbon monoxide derived from radiances measured by the 640 GHz radiometer. The current...

  17. MLS/Aura L2 Hydroperoxy (HO2) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HO2 is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydroperoxy derived from radiances measured in two bands from the 640 GHz radiometer. The...

  18. MLS/Aura L2 Hydroperoxy (HO2) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HO2 is the EOS Aura Microwave Limb Sounder (MLS) standard product for hydroperoxy derived from radiances measured in two bands from the 640 GHz radiometer. The...

  19. MLS/Aura L2 Bromine Monoxide (BRO) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2BRO is the EOS Aura Microwave Limb Sounder (MLS) standard product for bromine monoxide derived from radiances measured by the 640 GHz radiometer. The current...

  20. MLS/Aura Level 2 Sulfur Dioxide (SO2) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2SO2 is the EOS Aura Microwave Limb Sounder (MLS) standard product for sulfur dioxide derived from radiances measured by the 240 GHz radiometer. The current...

  1. MLS/Aura L2 Sulfur Dioxide (SO2) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2SO2 is the EOS Aura Microwave Limb Sounder (MLS) standard product for sulfur dioxide derived from radiances measured by the 240 GHz radiometer. The current...

  2. MLS/Aura L2 Nitrous Oxide (N2O) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2N2O is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitrous oxide derived from radiances measured primarily by the 640 GHz radiometer (Band 12)...

  3. MLS/Aura L2 Ozone (O3) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2O3 is the EOS Aura Microwave Limb Sounder (MLS) standard product for ozone derived from radiances measured by the 240 GHz radiometer. The current version is 2.2....

  4. MLS/Aura L2 Methyl Cyanide (CH3CN) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CH3CN is the EOS Aura Microwave Limb Sounder (MLS) standard product for methyl cyanide derived from radiances measured by the 190 GHz radiometer. The current...

  5. MLS/Aura Level 2 Ozone (O3) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2O3 is the EOS Aura Microwave Limb Sounder (MLS) standard product for ozone derived from radiances measured by the 240 GHz radiometer. The current version is 4.2....

  6. MLS/Aura L2 Chlorine Monoxide (ClO) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CLO is the EOS Aura Microwave Limb Sounder (MLS) standard product for chlorine monoxide derived from radiances measured primarily by the 640 GHz radiometer. The...

  7. MLS/Aura L2 Methyl Chloride (CH3CL) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CH3CL is the EOS Aura Microwave Limb Sounder (MLS) standard product for methyl chloride derived from radiances measured by the 640 GHz radiometer. The current...

  8. MLS/Aura L2 Ozone (O3) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2O3 is the EOS Aura Microwave Limb Sounder (MLS) standard product for ozone derived from radiances measured by the 240 GHz radiometer. The current version is...

  9. MLS/Aura L2 Methyl Cyanide (CH3CN) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CH3CN is the EOS Aura Microwave Limb Sounder (MLS) standard product for methyl cyanide derived from radiances measured by the 640 GHz radiometer. The current...

  10. MLS/Aura Level 2 Methanol (CH3OH) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — At this time it is recommended that these data not be used pending further validation. ML2CH3OH is the EOS Aura Microwave Limb Sounder (MLS) standard product for...

  11. MLS/Aura Level 2 Water Vapor (H2O) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2H2O is the EOS Aura Microwave Limb Sounder (MLS) standard product for water vapor derived from radiances measured primarily by the 190 GHz radiometer. The current...

  12. MLS/Aura L2 Carbon Monoxide (CO) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CO is the EOS Aura Microwave Limb Sounder (MLS) standard product for carbon monoxide derived from radiances measured by the 640 GHz radiometer. The current...

  13. MLS/Aura L2 Bromine Monoxide (BRO) Mixing Ratio V002

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2BRO is the EOS Aura Microwave Limb Sounder (MLS) standard product for bromine monoxide derived from radiances measured by the 640 GHz radiometer. The current...

  14. MLS/Aura Level 2 Methyl Chloride (CH3CL) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CH3CL is the EOS Aura Microwave Limb Sounder (MLS) standard product for methyl chloride derived from radiances measured by the 640 GHz radiometer. The current...

  15. MLS/Aura L2 Water Vapor (H2O) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2H2O is the EOS Aura Microwave Limb Sounder (MLS) standard product for water vapor derived from radiances measured primarily by the 190 GHz radiometer. The current...

  16. MLS/Aura Level 2 Chlorine Monoxide (ClO) Mixing Ratio V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CLO is the EOS Aura Microwave Limb Sounder (MLS) standard product for chlorine monoxide derived from radiances measured primarily by the 640 GHz radiometer. The...

  17. Recent Divergences Between Stratospheric Water Vapor Measurements by Aura MLS and Frost Point Hygrometers

    Science.gov (United States)

    Hurst, D. F.; Rosenlof, K. H.; Davis, S. M.; Hall, E. G.; Jordan, A. F.; Read, W. G.; Voemel, H.; Selkirk, H. B.

    2015-12-01

    A recent comparison of stratospheric water vapor measurements by the Aura Microwave Limb Sounder (MLS) and frost point hygrometers (FPs) during 2004-2012 reported agreement better than 1% from 68 to 26 hPa, small but statistically significant biases at 83 and 100 hPa, and no compelling evidence of long-term linear trends in FP-MLS differences [Hurst et al., 2014]. A previous comparison [Voemel et al., 2007] also found good agreement above 83 hPa. Recently it has become evident that differences between FP and MLS stratospheric water vapor measurements have widened during the last 5 years at two Northern Hemisphere (NH) mid-latitude sounding sites. Here we examine differences between coincident MLS and FP measurements of stratospheric water vapor at five sounding sites: two in the NH mid-latitudes (Boulder, Colorado and Lindenberg, Germany), two in the tropics (San Jose, Costa Rica and Hilo, Hawaii), and one in the SH mid-latitudes (Lauder, New Zealand). Analyses of the Boulder and Lindenberg data reveal reasonably uniform breakpoints in the timeseries of FP-MLS differences throughout the stratosphere, indicating that trends after mid-2010 are statistically different from trends before mid-2010. At Boulder and Lindenberg the post-breakpoint trends are statistically significant and fairly consistent over eight MLS retrieval pressures (100-26 hPa), averaging -0.08 ± 0.02 and -0.05 ± 0.02 ppmv per year, respectively (Figure 1). These translate to mean changes in stratospheric FP-MLS differences of -0.42 ± 0.08 ppmv (-10 ± 2%) and -0.23 ± 0.08 ppmv (-6 ± 2%) between mid-2010 and mid-2015. Breakpoints for the eight MLS pressure levels above Lauder are less uniform than for the two NH sites, however forced breakpoints of mid-2010 produce a mean stratospheric trend of -0.05 ± 0.02 ppmv per year in the FP-MLS differences. Breakpoints for the two tropical sites are inconsistent, as are the trend results with forced breakpoints of mid-2010. Hurst, D.F., et al., (2014

  18. An MLS coherence function and its performance in measurements on time-varying systems

    DEFF Research Database (Denmark)

    Liu, Jiyuan; Jacobsen, Finn

    1999-01-01

    A new MLS coherence function has been developed and tested in various room acoustic measurements. The new measure, which takes values between zero and unity just as the ordinary coherence, can be used only if averaging over several periods of the MLS signal is carried out. It indicates possible...... contamination by extraneous noise in the same manner as the the ordinary coherence function does in measurements with FFT analysers. It is also very sensitive to disturbances such as reflections caused by moving surfaces during the measurement. Very weak time-variance effects caused by a small change...

  19. MODIS/Aqua Cld Mask Spect. Test Results 5-Min L2 Swath Subset along MLS V002 (MAM35S0) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — This is the MODIS/Aqua subset along MLS field of view track. The goal of the subset is to select and return MODIS data that are within +-100 km across the MLS track....

  20. MODIS/Aqua Temp and Water Vapor Profile 5-Min L2 Swath Subset 5km subset along MLS V002 (MAM07S0) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — This is the MODIS/Aqua subset along MLS field of view track. The goal of the subset is to select and return MODIS data that are within +-100 km across the MLS track....

  1. MODIS/Aqua Aerosol 5-Min L2 Swath Subset 10km along MLS V002 (MAM04S0) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — This is the MODIS/Aqua subset along MLS field of view track. The goal of the subset is to select and return MODIS data that are within +-100 km across the MLS track....

  2. MODIS/Aqua Clouds 1km and 5km 5-Min L2 Swath Subset along MLS V002 (MAM06S0) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — This is the MODIS/Aqua subset along MLS field of view track. The goal of the subset is to select and return MODIS data that are within +-100 km across the MLS track....

  3. 78 FR 74157 - Notice of HUD-Held Multifamily Loan Sale (MLS 2014-1)

    Science.gov (United States)

    2013-12-10

    ... intention to sell an unsubsidized multifamily mortgage loan, without Federal Housing Administration (FHA... INFORMATION: HUD announces its intention to sell, in MLS 2014-1, an individual unsubsidized multifamily... non-refundable and will be applied toward the purchase price. Deposits will be returned to...

  4. 76 FR 47226 - Notice of HUD-Held Multifamily Loan Sale (MLS 2011-2)

    Science.gov (United States)

    2011-08-04

    ... negotiation. Due Diligence Review The BIP described the due diligence process for reviewing loan files in MLS...-2: (1) Any employee of HUD, a member of such employee's household, or an entity owned or controlled by any such employee or member of such an employee's household; (2) Any individual or entity that is...

  5. 76 FR 24045 - Notice of HUD-Held Multifamily Loan Sale (MLS 2011-1)

    Science.gov (United States)

    2011-04-29

    ... Agreement were not subject to negotiation. Due Diligence Review The BIP described the due diligence process... Mortgage Loans included in MLS 2011-1: (1) Any employee of HUD, a member of such employee's household, or an entity owned or controlled by any such employee or member of such an employee's household; (2) Any...

  6. Automatic Registration of TLS-TLS and TLS-MLS Point Clouds Using a Genetic Algorithm.

    Science.gov (United States)

    Yan, Li; Tan, Junxiang; Liu, Hua; Xie, Hong; Chen, Changjun

    2017-08-29

    Registration of point clouds is a fundamental issue in Light Detection and Ranging (LiDAR) remote sensing because point clouds scanned from multiple scan stations or by different platforms need to be transformed to a uniform coordinate reference frame. This paper proposes an efficient registration method based on genetic algorithm (GA) for automatic alignment of two terrestrial LiDAR scanning (TLS) point clouds (TLS-TLS point clouds) and alignment between TLS and mobile LiDAR scanning (MLS) point clouds (TLS-MLS point clouds). The scanning station position acquired by the TLS built-in GPS and the quasi-horizontal orientation of the LiDAR sensor in data acquisition are used as constraints to narrow the search space in GA. A new fitness function to evaluate the solutions for GA, named as Normalized Sum of Matching Scores, is proposed for accurate registration. Our method is divided into five steps: selection of matching points, initialization of population, transformation of matching points, calculation of fitness values, and genetic operation. The method is verified using a TLS-TLS data set and a TLS-MLS data set. The experimental results indicate that the RMSE of registration of TLS-TLS point clouds is 3~5 mm, and that of TLS-MLS point clouds is 2~4 cm. The registration integrating the existing well-known ICP with GA is further proposed to accelerate the optimization and its optimizing time decreases by about 50%.

  7. Global Carbon Monoxide Products from Combined AIRS, TES and MLS Measurements on A-Train Satellites

    Science.gov (United States)

    Warner, Juying X.; Yang, R.; Wei, Z.; Carminati, F.; Tangborn, A.; Sun, Z.; Lahoz, W.; Attie, J. L.; El Amraoui, L.; Duncan, B.

    2014-01-01

    This study tests a novel methodology to add value to satellite data sets. This methodology, data fusion, is similar to data assimilation, except that the background modelbased field is replaced by a satellite data set, in this case AIRS (Atmospheric Infrared Sounder) carbon monoxide (CO) measurements. The observational information comes from CO measurements with lower spatial coverage than AIRS, namely, from TES (Tropospheric Emission Spectrometer) and MLS (Microwave Limb Sounder). We show that combining these data sets with data fusion uses the higher spectral resolution of TES to extend AIRS CO observational sensitivity to the lower troposphere, a region especially important for air quality studies. We also show that combined CO measurements from AIRS and MLS provide enhanced information in the UTLS (upper troposphere/lower stratosphere) region compared to each product individually. The combined AIRS-TES and AIRS-MLS CO products are validated against DACOM (differential absorption mid-IR diode laser spectrometer) in situ CO measurements from the INTEX-B (Intercontinental Chemical Transport Experiment: MILAGRO and Pacific phases) field campaign and in situ data from HIPPO (HIAPER Pole-to-Pole Observations) flights. The data fusion results show improved sensitivities in the lower and upper troposphere (20-30% and above 20%, respectively) as compared with AIRS-only version 5 CO retrievals, and improved daily coverage compared with TES and MLS CO data.

  8. MLS/Aura Near-Real-Time L2 Ozone (O3) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2O3_NRT is the EOS Aura Microwave Limb Sounder (MLS) Near-Real-Time (NRT) product for ozone (O3). This product contains daily O3 profiles taken from the 240 GHz...

  9. Effect of multiple path approach procedures on runway landing capacity. [under ILS and MLS conditions

    Science.gov (United States)

    Tosic, V.; Horonjeff, R.

    1976-01-01

    When using the Instrument Landing System (ILS) all aircraft must follow a straight line approach path before landing. The Microwave Landing System (MLS) will allow use of differing curved approach paths. The objective of this research is to find out whether the introduction of MLS and consequently multiple approach paths can bring an increase in runway landing capacity. A model is developed which is capable of computing the expected ultimate landing runway capacity, under ILS and MLS conditions, when aircraft population characteristics and Air Traffic Control separation rules are given. This model can be applied in situations when only a horizontal separation between aircraft approaching a runway is allowed, as well as when both vertical and horizontal separations are possible. Results suggest that an increase in runway landing capacity, caused by introducing the MLS-described multiple approach paths, is to be expected only when an aircraft population consists of aircraft with significantly differing approach velocities and particularly in situations when a vertical separation can be applied.

  10. Graph SLAM correction for single scanner MLS forest data under boreal forest canopy

    Science.gov (United States)

    Kukko, Antero; Kaijaluoto, Risto; Kaartinen, Harri; Lehtola, Ville V.; Jaakkola, Anttoni; Hyyppä, Juha

    2017-10-01

    Mobile laser scanning (MLS) provides kinematic means to collect three dimensional data from surroundings for various mapping and environmental analysis purposes. Vehicle based MLS has been used for road and urban asset surveys for about a decade. The equipment to derive the trajectory information for the point cloud generation from the laser data is almost without exception based on GNSS-IMU (Global Navigation Satellite System - Inertial Measurement Unit) technique. That is because of the GNSS ability to maintain global accuracy, and IMU to produce the attitude information needed to orientate the laser scanning and imaging sensor data. However, there are known challenges in maintaining accurate positioning when GNSS signal is weak or even absent over long periods of time. The duration of the signal loss affects the severity of degradation of the positioning solution depending on the quality/performance level of the IMU in use. The situation could be improved to a certain extent with higher performance IMUs, but increasing system expenses make such approach unsustainable in general. Another way to tackle the problem is to attach additional sensors to the system to overcome the degrading position accuracy: such that observe features from the environment to solve for short term system movements accurately enough to prevent the IMU solution to drift. This results in more complex system integration with need for more calibration and synchronization of multiple sensors into an operational approach. In this paper we study operation of an ATV (All -terrain vehicle) mounted, GNSS-IMU based single scanner MLS system in boreal forest conditions. The data generated by RoamerR2 system is targeted for generating 3D terrain and tree maps for optimizing harvester operations and forest inventory purposes at individual tree level. We investigate a process-flow and propose a graph optimization based method which uses data from a single scanner MLS for correcting the post

  11. Science Accomplishments from a Decade of Aura OMI/MLS Tropospheric Ozone Measurements

    Science.gov (United States)

    Ziemke, Jerald R.; Douglass, Anne R.; Joiner, Joanna; Duncan, Bryan N.; Olsen, Mark A.; Oman, Luke D.; Witte, Jacquelyn C.; Liu, X.; Wargan, K.; Schoeberl, Mark R.; hide

    2014-01-01

    Measurements of tropospheric ozone from combined Aura OMI and MLS instruments have yielded a large number of new and important science discoveries over the last decade. These discoveries have generated a much greater understanding of biomass burning, lightning NO, and stratosphere-troposphere exchange sources of tropospheric ozone, ENSO dynamics and photochemistry, intra-seasonal variability-Madden-Julian Oscillation including convective transport, radiative forcing, measuring ozone pollution from space, improvements to ozone retrieval algorithms, and evaluation of chemical-transport and chemistry-climate models. The OMI-MLS measurements have been instrumental in giving us better understanding of the dynamics and chemistry involving tropospheric ozone and the many drivers affecting the troposphere in general. This discussion will provide an overview focusing on our main science results.

  12. Enhanced Positive Water Vapor Feedback Associated with Tropical Deep Convection: New Evidence from Aura MLS

    Science.gov (United States)

    Su, Hui; Read, William G.; Jiang, Jonathan H.; Waters, Joe W.; Wu, Dong L.; Fetzer, Eric J.

    2006-01-01

    Recent simultaneous observations of upper tropospheric (UT) water vapor and cloud ice from the Microwave Limb Sounder (MLS) on the Aura satellite provide new evidence for tropical convective influence on UT water vapor and its associated greenhouse effect. The observations show that UT water vapor increases as cloud ice water content increases. They also show that, when sea surface temperature (SST) exceeds approx.300 K, UT cloud ice associated with tropical deep convection increases sharply with increasing SST. The moistening of the upper troposphere by deep convection leads to an enhanced positive water vapor feedback, about 3 times that implied solely by thermodynamics. Over tropical oceans when SST greater than approx.300 K, the 'convective UT water vapor feedback' inferred from the MLS observations contributes approximately 65% of the sensitivity of the clear-sky greenhouse parameter to SST.

  13. MLS/Aura Near-Real-Time L2 Sulfur Dioxide (SO2) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2SO2_NRT is the EOS Aura Microwave Limb Sounder (MLS) Near-Real-Time (NRT) product for sulfur dioxide (SO2). This product contains daily SO2 profiles taken from...

  14. MLS/Aura Level 3 Bromine Monoxide (BrO) Daily 10deg Lat Zonal Mean V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML3DZMBRO is the EOS Aura Microwave Limb Sounder (MLS) daily zonal mean product for bromine monoxide derived from radiances measured by the 640 GHz radiometer. The...

  15. MLS/Aura Level 2 Nitric Acid (HNO3) Mixing Ratio V003 (ML2HNO3) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HNO3 is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitric acid derived from radiances measured by the 240 GHz radiometer at and below 10 hPa,...

  16. MLS/Aura Level 2 Hypochlorous Acid (HOCl) Mixing Ratio V003 (ML2HOCL) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HOCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hypochlorous acid derived from radiances measured primarily by the 640 GHz radiometer. The...

  17. MLS/Aura Level 2 Nitric Acid (HNO3) Mixing Ratio V004 (ML2HNO3) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HNO3 is the EOS Aura Microwave Limb Sounder (MLS) standard product for nitric acid derived from radiances measured by the 240 GHz radiometer at and below 10 hPa,...

  18. MLS/Aura Level 3 Bromine Monoxide (BrO) Daily 10deg Lat Zonal Mean V004

    Data.gov (United States)

    National Aeronautics and Space Administration — ML3DZMBRO is the EOS Aura Microwave Limb Sounder (MLS) daily zonal mean product for bromine monoxide derived from radiances measured by the 640 GHz radiometer. The...

  19. MLS/Aura L1 Radiances from Digital Autocorrelators V003 (ML1RADD) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML1RADD is the EOS Aura Microwave Limb Sounder (MLS) product containing the level 1 radiances from the digital autocorrelators. The data version is 3.3/3.4. Data...

  20. MLS/Aura Near-Real-Time L2 Nitric Acid (HNO3) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HNO3_NRT is the EOS Aura Microwave Limb Sounder (MLS) Near-Real-Time (NRT) product for nitric acid (HNO3). This product contains daily HNO3 profiles taken from...

  1. MLS/Aura Level 2 Hypochlorous Acid (HOCl) Mixing Ratio V004 (ML2HOCL) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2HOCL is the EOS Aura Microwave Limb Sounder (MLS) standard product for hypochlorous acid derived from radiances measured primarily by the 640 GHz radiometer. The...

  2. Promoting Professionalism, and Academic Librarianship: Observations on the Marketing of the M.L.S.

    Directory of Open Access Journals (Sweden)

    Brian Cameron

    2007-09-01

    Full Text Available Despite the requirement for librarians to hold an MLS or equivalent, many libraries have not sought opportunities to publicize their credentials. In the college and university environment, this is surprising given the importance placed on credentials and advanced degrees. A brief survey of academic library websites reveals that few are using the web to publicize librarian credentials, and as a result, are missing opportunities to promote their expertise and advanced qualifications to their community.

  3. Promoting Professionalism, and Academic Librarianship: Observations on the Marketing of the M.L.S.

    Directory of Open Access Journals (Sweden)

    Brian Cameron

    2007-12-01

    Full Text Available Despite the requirement for librarians to hold an MLS or equivalent, many libraries have not sought opportunities to publicize their credentials. In the college and university environment, this is surprising given the importance placed on credentials and advanced degrees. A brief survey of academic library websites reveals that few are using the web to publicize librarian credentials, and as a result, are missing opportunities to promote their expertise and advanced qualifications to their community.

  4. A global climatology of tropospheric and stratospheric ozone derived from Aura OMI and MLS measurements

    Directory of Open Access Journals (Sweden)

    J. R. Ziemke

    2011-09-01

    Full Text Available A global climatology of tropospheric and stratospheric column ozone is derived by combining six years of Aura Ozone Monitoring Instrument (OMI and Microwave Limb Sounder (MLS ozone measurements for the period October 2004 through December 2010. The OMI/MLS tropospheric ozone climatology exhibits large temporal and spatial variability which includes ozone accumulation zones in the tropical south Atlantic year-round and in the subtropical Mediterranean/Asia region in summer months. High levels of tropospheric ozone in the Northern Hemisphere also persist in mid-latitudes over the eastern part of the North American continent extending across the Atlantic Ocean and the eastern part of the Asian continent extending across the Pacific Ocean. For stratospheric ozone climatology from MLS, largest column abundance is in the Northern Hemisphere in the latitude range 70° N–80° N in February–April and in the Southern Hemisphere around 40° S–50° S during August–October. Largest stratospheric ozone lies in the Northern Hemisphere and extends from the eastern Asian continent eastward across the Pacific Ocean and North America. With the advent of many newly developing 3-D chemistry and transport models it is advantageous to have such a dataset for evaluating the performance of the models in relation to dynamical and photochemical processes controlling the ozone distributions in the troposphere and stratosphere. The OMI/MLS gridded ozone climatology data are made available to the science community via the NASA Goddard Space Flight Center ozone and air quality website http://ozoneaq.gsfc.nasa.gov/.

  5. A Global Climatology of Tropospheric and Stratospheric Ozone Derived from Aura OMI and MLS Measurements

    Science.gov (United States)

    Ziemke, J.R.; Chandra, S.; Labow, G.; Bhartia, P. K.; Froidevaux, L.; Witte, J. C.

    2011-01-01

    A global climatology of tropospheric and stratospheric column ozone is derived by combining six years of Aura Ozone Monitoring Instrument (OMI) and Microwave Limb Sounder (MLS) ozone measurements for the period October 2004 through December 2010. The OMI/MLS tropospheric ozone climatology exhibits large temporal and spatial variability which includes ozone accumulation zones in the tropical south Atlantic year-round and in the subtropical Mediterranean! Asia region in summer months. High levels of tropospheric ozone in the northern hemisphere also persist in mid-latitudes over the eastern North American and Asian continents extending eastward over the Pacific Ocean. For stratospheric ozone climatology from MLS, largest ozone abundance lies in the northern hemisphere in the latitude range 70degN-80degN in February-April and in the southern hemisphere around 40degS-50degS during months August-October. The largest stratospheric ozone abundances in the northern hemisphere lie over North America and eastern Asia extending eastward across the Pacific Ocean and in the southern hemisphere south of Australia extending eastward across the dateline. With the advent of many newly developing 3D chemistry and transport models it is advantageous to have such a dataset for evaluating the performance of the models in relation to dynamical and photochemical processes controlling the ozone distributions in the troposphere and stratosphere.

  6. Models for estimating runway landing capacity with Microwave Landing System (MLS)

    Science.gov (United States)

    Tosic, V.; Horonjeff, R.

    1975-01-01

    A model is developed which is capable of computing the ultimate landing runway capacity, under ILS and MLS conditions, when aircraft population characteristics and air traffic control separation rules are given. This model can be applied in situations when only a horizontal separation between aircraft approaching a runway is allowed, as well as when both vertical and horizontal separations are possible. It is assumed that the system is free of errors, that is that aircraft arrive at specified points along the prescribed flight path precisely when the controllers intend for them to arrive at these points. Although in the real world there is no such thing as an error-free system, the assumption is adequate for a qualitative comparison of MLS with ILS. Results suggest that an increase in runway landing capacity, caused by introducing the MLS multiple approach paths, is to be expected only when an aircraft population consists of aircraft with significantly differing approach speeds and particularly in situations when vertical separation can be applied. Vertical separation can only be applied if one of the types of aircraft in the mix has a very steep descent angle.

  7. MLS data segmentation using Point Cloud Library procedures. (Polish Title: Segmentacja danych MLS z użyciem procedur Point Cloud Library)

    Science.gov (United States)

    Grochocka, M.

    2013-12-01

    Mobile laser scanning is dynamically developing measurement technology, which is becoming increasingly widespread in acquiring three-dimensional spatial information. Continuous technical progress based on the use of new tools, technology development, and thus the use of existing resources in a better way, reveals new horizons of extensive use of MLS technology. Mobile laser scanning system is usually used for mapping linear objects, and in particular the inventory of roads, railways, bridges, shorelines, shafts, tunnels, and even geometrically complex urban spaces. The measurement is done from the perspective of use of the object, however, does not interfere with the possibilities of movement and work. This paper presents the initial results of the segmentation data acquired by the MLS. The data used in this work was obtained as part of an inventory measurement infrastructure railway line. Measurement of point clouds was carried out using a profile scanners installed on the railway platform. To process the data, the tools of 'open source' Point Cloud Library was used. These tools allow to use templates of programming libraries. PCL is an open, independent project, operating on a large scale for processing 2D/3D image and point clouds. Software PCL is released under the terms of the BSD license (Berkeley Software Distribution License), which means it is a free for commercial and research use. The article presents a number of issues related to the use of this software and its capabilities. Segmentation data is based on applying the templates library pcl_ segmentation, which contains the segmentation algorithms to separate clusters. These algorithms are best suited to the processing point clouds, consisting of a number of spatially isolated regions. Template library performs the extraction of the cluster based on the fit of the model by the consensus method samples for various parametric models (planes, cylinders, spheres, lines, etc.). Most of the mathematical

  8. Evaluation of UTLS Carbon Monoxide Simulations in GMI and GEOS-Chem Chemical Transport Models using Aura MLS Observations

    Science.gov (United States)

    Huang, Lei; Jiang, Jonathan H.; Murray, Lee T.; Damon, Megan R.; Su, Hui; Livesey, Nathaniel J.

    2016-01-01

    This study evaluates the distribution and variation of carbon monoxide (CO) in the upper troposphere and lower stratosphere (UTLS) during 2004-2012 as simulated by two chemical transport models, using the latest version of Aura Microwave Limb Sounder (MLS) observations. The simulated spatial distributions, temporal variations and vertical transport of CO in the UTLS region are compared with those observed by MLS. We also investigate the impact of surface emissions and deep convection on CO concentrations in the UTLS over different regions, using both model simulations and MLS observations. Global Modeling Initiative (GMI) and GEOS-Chem simulations of UTLS CO both show similar spatial distributions to observations. The global mean CO values simulated by both models agree with MLS observations at 215 and 147 hPa, but are significantly underestimated by more than 40% at 100 hPa. In addition, the models underestimate the peak CO values by up to 70% at 100 hPa, 60% at 147 hPa and 40% at 215 hPa, with GEOS-Chem generally simulating more CO at 100 hPa and less CO at 215 hPa than GMI. The seasonal distributions of CO simulated by both models are in better agreement with MLS in the Southern Hemisphere (SH) than in the Northern Hemisphere (NH), with disagreements between model and observations over enhanced CO regions such as southern Africa. The simulated vertical transport of CO shows better agreement with MLS in the tropics and the SH subtropics than the NH subtropics. We also examine regional variations in the relationships among surface CO emission, convection and UTLS CO concentrations. The two models exhibit emission-convection- CO relationships similar to those observed by MLS over the tropics and some regions with enhanced UTLS CO.

  9. Review of operational aspects of initial experiments utilizing the U.S. MLS. [microwave landing system effectiveness

    Science.gov (United States)

    Walsh, T. M.; Morello, S. A.; Reeder, J. P.

    1976-01-01

    An exercise to support the Federal Aviation Administration in demonstrating the U.S. candidate for an international microwave landing system (MLS) was conducted by NASA. During this demonstration the MLS was utilized to provide the TCV Boeing 737 research airplane with guidance for automatic control during transition from conventional RNAV to MLS RNAV in curved, descending flight; flare; touchdown; and roll-out. Flight profiles, system configuration, displays, and operating procedures used in the demonstration are described, and preliminary results of flight data analysis are discussed. Recent experiences with manually controlled flight in the NAFEC MLS environment are also discussed. The demonstration shows that in automatic three-dimensional flight, the volumetric signal coverage of the MLS can be exploited to enable a commercial carrier class airplane to perform complex curved, descending paths with precision turns into short final approaches terminating in landing and roll-out, even when subjected to strong and gusty tail and cross wind components and severe wind shear.

  10. Comparison of GOME-2/Metop-A ozone profiles with GOMOS, OSIRIS and MLS measurements

    Science.gov (United States)

    Määttä, A.; Tuinder, O. N. E.; Tukiainen, S.; Sofieva, V.; Tamminen, J.

    2015-07-01

    This paper presents a comparison of vertical ozone profiles retrieved by the Ozone ProfilE Retrieval Algorithm (OPERA) from the Global Ozone Monitoring Experiment 2 (GOME-2) measurements on board Metop-A with high-vertical-resolution ozone profiles by Global Ozone Monitoring by Occultation of Stars (GOMOS), Optical Spectrograph and Infrared Imager System (OSIRIS) and Microwave Limb Sounder (MLS). The comparison, with global coverage, focuses on the stratosphere and the lower mesosphere and covers the period from March 2008 until the end of 2011. The comparison shows an agreement of the GOME-2 ozone profiles with those of GOMOS, OSIRIS and MLS within ±15 % in the altitude range from 15 km up to ~ 35-40 km depending on latitude. The GOME-2 ozone profiles from non-degradation corrected radiances have a tendency to a systematic negative bias with respect to the reference data above ~ 30 km. The GOME-2 bias with respect to the high-vertical resolution instruments depends on season, with the strongest dependence observed at high latitudes.

  11. Comparative study of aircraft approach and landing performance using ILS, MLS and GLS

    Science.gov (United States)

    Ferdous, Mahbuba; Rashid, Mohsina; China, Mst Mowsumie Akhter; Hossam-E-Haider, Md

    2017-12-01

    Aircraft landing is one of the most challenging stages of a flight. At this stage, the risk for aircraft to be drifted away from the runway or to collide with other aircraft is very high. So, a supreme accuracy is required to guide aircraft to runway touchdown point precisely. And the precision of approaches are permitted by means of appropriate ground and airborne systems such as Instrument Landing System (ILS) and Microwave Landing System (MLS). Also satellite-based systems can be used like Global Positioning System (GPS) via augmented information supplied by ground-based systems (GBAS). This paper provides an overall review over aircraft performance with different landing aids available to enable the aircraft for executing a safe landing. It encompasses the performance of different landing systems in relation to azimuth and elevation information provided to the pilot and also the different errors encountered by them. This paper also addresses that in addition to eliminating the errors of ground based systems (ILS or MLS), the augmented GPS or GBAS is able to fulfill the ICAO aircraft landing category CAT I to CAT IIIB requirements. And category CAT IIIC standards are still not in use anywhere in the world which require landing with no visibility and runway visual range.

  12. The accuracy of remotely-sensed IWC: An assessment from MLS, TRMM and CloudSat statistics

    Science.gov (United States)

    Wu, D. L.; Heymsfield, A. J.

    2006-12-01

    Understanding climate change requires accurate global cloud ice water content (IWC) measurements. Satellite remote sensing has been the major tool to provide such global observations, but the accuracy of deduced IWC depends on knowledge of cloud microphysics learned from in-situ samples. Because only limited number and type of ice clouds have been measured by in-situ sensors, the knowledge about cloud microphysics is incomplete, and the IWC accuracy from remote sensing can vary from 30% to 200% from case to case. Recent observations from MLS, TRMM and CloudSat allow us to evaluate consistency and accuracy of IWCs deduced from passive and active satellite techniques. In this study we conduct statistical analyses on the tropical and subtropical IWCs observed by MLS, TRMM and CloudSat. The probability density functions (PDFs) of IWC are found to depend on the volume size of averaging, and therefore data need to be averaged into the same volume in order for fair comparisons. Showing measurement noise, bias and sensitivity, the PDF is a better characterization than an average for evaluating IWC accuracy because an averaged IWC depends on cloud-detection threshold that can vary from sensor to sensor. Different thresholds will not only change the average value but also change cloud fraction and occurrence frequency. Our study shows that MLS and TRMM IWCs, despite large differences in sensitivity with little overlap, can still be compared under PDF. The two statistics are generally consistent within 50% at ~13 km, obeying an approximate lognormal distribution as suggested by some ground-based radar observations. MLS has sensitivity to IWC of 1-100 mg/m3 whereas TRMM can improve its sensitivity to IWC as low as 70 mg/m3 if the radar data are averaged properly for the equivalent volume of MLS samples. The proper statistical averaging requires full characteristics of IWC noise, which are not available for products normally derived from radar reflectivity, and therefore we

  13. MODIS/Aqua Total Precip Water Vapor 1km and 5km 5-Min L2 Swath Subset along MLS V002 (MAM05S0) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — This is the MODIS/Aqua subset along MLS field of view track. The goal of the subset is to select and return MODIS data that are within +-100 km across the MLS track....

  14. Design and development of a MLS based compact active suspension system, featuring air spring and energy harvesting capabilities

    DEFF Research Database (Denmark)

    Berg, Nick Ilsø; Holm, Rasmus Koldborg; Rasmussen, Peter Omand

    2016-01-01

    This paper describes the design and development of an novel Magnetic Lead Screw based active suspension system for passenger vehicles, using a new MLS topology. The design is based on performance specifications found from ISO road profiles, with a maximum harvested energy approach. By integrating...

  15. Keeping Pace with Information Literacy Instruction for the Real World: When Will MLS Programs Wake Up and Smell the LILACs?

    Science.gov (United States)

    Davies-Hoffman, Kimberly; Alvarez, Barbara; Costello, Michelle; Emerson, Debby

    2013-01-01

    For over thirty years, numerous studies have discussed the contradiction between the growing importance of information literacy instruction to the Library's core mission and lack of pedagogical training for new librarians. This article reviews the more recent contributions on the topic, presents a survey of New York State MLS curricula and…

  16. MLS/Aura Near-Real-Time L2 Water Vapor (H2O) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CO_NRT is the EOS Aura Microwave Limb Sounder (MLS) Near-Real-Time (NRT) product for water vapor (H2O). This product contains daily H2O profiles taken from the...

  17. MLS/Aura Near-Real-Time L2 Nitrous Oxide (N2O) Mixing Ratio V003

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2N2O_NRT is the EOS Aura Microwave Limb Sounder (MLS) Near-Real-Time (NRT) product for nitrous oxide (N2O). This product contains daily N2O profiles taken from the...

  18. Assimilating EOS-Aura OMI and MLS Data in GEOS-5

    Science.gov (United States)

    Pawson, Steven; Xu, Philippe; Douglass, Anne R.; Olsen, Mark; Strahan, Susan; Nielsen, J. Eric; McKee, Nicole; Sienkiewicz, Meta; Wargan, Krzysztof

    2009-01-01

    Data assimilation is a potentially powerful method of extracting the maximum amount of information from observed data by combining their information with models. in this application, we will use stratospheric ozone profiles retrieved from EOS MLS and total column amounts retrieved from OMI' along with the GEOS-5 GCM, that includes a representation of ozone chemistry and transport. The presentation will discuss how well we can derive tropospheric ozone column information in this system, including its sensitivity to model errors and some assumptions made in the assimilation system. We discuss also ozone structures in the tropopause region and their sensitivity to model resolution and other fact=ors. An important issue we examine is how much more information we obtain from ozone assimilation than from model studies using state of the art chemistry models - answering such questions helps determine how useful ozone assimilation really is, given our present capabilities in chemical modeling.

  19. Validation of 10-year SAO OMI ozone profile (PROFOZ) product using Aura MLS measurements

    Science.gov (United States)

    Huang, Guanyu; Liu, Xiong; Chance, Kelly; Yang, Kai; Cai, Zhaonan

    2018-01-01

    We validate the Ozone Monitoring Instrument (OMI) ozone profile (PROFOZ v0.9.3) product including ozone profiles between 0.22 and 261 hPa and stratospheric ozone columns (SOCs) down to 100, 215, and 261 hPa from October 2004 through December 2014 retrieved by the Smithsonian Astrophysical Observatory (SAO) algorithm against the latest Microwave Limb Sound (MLS) v4.2x data. We also evaluate the effects of OMI row anomaly (RA) on the retrieval by dividing the data set into before and after the occurrence of serious RA, i.e., pre-RA (2004-2008) and post-RA (2009-2014). During the pre-RA period, OMI ozone profiles agree very well with MLS data. After applying OMI averaging kernels to MLS data, the global mean biases (MBs) are within 3 % between 0.22 and 100 hPa, negative biases are within 3-9 % for lower layers, and the standard deviations (SDs) are 3.5-5 % from 1 to 40 hPa, 6-10 % for upper layers, and 5-20 % for lower layers. OMI shows biases dependent on latitude and solar zenith angle (SZA), but MBs and SDs are mostly within 10 % except for low and high altitudes of high latitudes and SZAs. Compared to the retrievals during the pre-RA period, OMI retrievals during the post-RA period degrade slightly between 5 and 261 hPa with MBs and SDs typically larger by 2-5 %, and degrade much more for pressure less than ˜ 5 hPa, with larger MBs by up to 8 % and SDs by up to 15 %, where the MBs are larger by 10-15 % south of 40° N due to the blockage effect of RA and smaller by 15-20 % north of 40° N due to the solar contamination effect of RA. The much worse comparisons at high altitudes indicate the UV1 channel of pixels that are not flagged as RA is still affected by the RA. During the pre-RA period, OMI SOCs show very good agreement with MLS data with global mean MBs within 0.6 % and SDs of 1.9 % for SOCs down to 215 and 261 hPa and of 2.30 % for SOC down to 100 hPa. Despite clearly worse ozone profile comparisons during the post-RA period, OMI SOCs only slightly degrade

  20. What is missing between model and Aura MLS observations in mesospheric OH?

    Science.gov (United States)

    Wang, S.; Li, K. F.; Zeng, Z.; Sander, S. P.; Shia, R. L.; Yung, Y. L.

    2017-12-01

    Recent Aura Microwave Limb Souder observations show higher mesospheric OH levels than earlier versions and previous satellite observations. The current photochemical model with standard chemistry is not able to accurately simulate MLS OH in the mesosphere. In particular, the model significantly underestimates OH over the altitude range of 60-80km. In the standard middle atmospheric chemistry, HOx over this altitude range is controled mainly through the reactions of H2O + hv (reactions within recommended uncertainty ranges using an objective Bayesian approach. However, reasonable perturbations to these reactions are not capable of resolving the mesospheric discrepancy without introducing disagreements in other regions of the atmosphere. We explore possible new reactions in the Earth's atmosphere that are not included in current standard models. Some candidate reactions and their potential impacts on mesospheric HOx chemistry will be discussed. Our results urge new laboratory studies of these candidate reactions, whose rate coefficients have never been measured for the atmospheric conditions.

  1. Aspects of Experimental Hepatocarcinogenesis | Timme | South ...

    African Journals Online (AJOL)

    Ultrastructural changes observed in the non-neoplastic liver included nucleolar hypertrophy, an increase in the smooth endoplasmic reticulum and abnormalities of mitochondria. The possibility that these findings may have a bearing on the occurrence of primary liver cancer in non-cirrhotic patients in high-incidence areas ...

  2. Aspects of Experimental Hepatocarcinogenesis | Timme | South ...

    African Journals Online (AJOL)

    An increase in free cytoplasmic ribosomes, prominence of the Golgi apparatus in the perinuclear area, microfilament bundles and abnormal microbodies were the most notable features observed. It is concluded that the 4 nodules and the 3 microscopic foci described in Part I may represent different stages of the same ...

  3. Aspects of Experimental Hepatocarcinogenesis | Timme | South ...

    African Journals Online (AJOL)

    , prominent perinuclear Golgi bodies and bundles of microfilaments. These features suggested that the cells were not merely regenerative in nature but represented a definite carcinogen-induced proliferative response. S. Afr. Med. J., 48, 698 ...

  4. Role of convection in hydration of tropical UTLS: implication of AURA MLS long-term observations

    Directory of Open Access Journals (Sweden)

    S. Jain

    2013-05-01

    Full Text Available This paper addresses various characteristic features associated with the hydration of the tropical upper troposphere and lower stratosphere (UTLS in association with the boreal monsoonal convective activity occurring over three different tropical regions viz. Asian region, American region and African region. Analysis of water vapor mixing ratio (WVMR data obtained from AURA MLS (v3.3, ISCCP D1 cloud top pressure data and outgoing long-wave radiation data (OLR from NOAA reanalysis has brought out two significant results. Firstly, high altitude clouds and high WVMR regions are mostly associated with the low OLR region. Convection over Asian region is very deep and spread over a large geographical area as compared to African or American region. Magnitude of WVMR in the pressure range of 261.0–146.8 hPa is observed to be higher over the Asian region, whereas, close to the tropopause level (~ 100 hPa it is comparable or more over the American region as compared to Asian and African regions. Secondly, the vertical ascent rate of water vapour obtained from AURA MLS data suggest that convection associated transport might have dominated up to 146.8–121.2 hPa in addition to slow large scale diabatic transport, which appears to be prominent above the pressure range of 100–82.5 hPa. Within the pressure levels of 121.2 to 82.5 hPa, the influence of convective transport appears to be gradually decreasing. However, there are other possible processes like ice sublimation or cirrus jumping which could contribute to the hydration of the tropical lower stratosphere. Present analysis has, thus, brought out the significance of convection in water vapour transport and distribution in the tropical UTLS. Another interesting feature which is observed is the anomalous increase in temperature during boreal winters (November–April over all three convective regions. Such phenomenon is only observed within the pressure range of 100.0–261.0 hPa; however it is

  5. MLS/Aura Level 2 Methyl Chloride (CH3CL) Mixing Ratio V003 (ML2CH3CL) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CH3CL is the EOS Aura Microwave Limb Sounder (MLS) standard product for methyl chloride derived from radiances measured by the 640 GHz radiometer. The data...

  6. MLS/Aura Level 2 Methyl Chloride (CH3CL) Mixing Ratio V004 (ML2CH3CL) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CH3CL is the EOS Aura Microwave Limb Sounder (MLS) standard product for methyl chloride derived from radiances measured by the 640 GHz radiometer. The data...

  7. MODIS/Aqua Geolocation Fields 1km 5-Min 1A Swath Subset along MLS V002 (MAM03S0) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — This is the MODIS/Aqua subset along the Microwave Limb Sounder (MLS) field of view track. The goal of the subset is to select and return MODIS data that are within...

  8. MLS/Aura Level 2 Methyl Cyanide (CH3CN) Mixing Ratio V004 (ML2CH3CN) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CH3CN is the EOS Aura Microwave Limb Sounder (MLS) standard product for methyl cyanide derived from radiances measured by the 640 GHz radiometer. The data version...

  9. MLS/Aura Level 2 Methyl Cyanide (CH3CN) Mixing Ratio V003 (ML2CH3CN) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2CH3CN is the EOS Aura Microwave Limb Sounder (MLS) standard product for methyl cyanide derived from radiances measured by the 640 GHz radiometer. The data version...

  10. MLS/Aura Level 2 Methanol (CH3OH) Mixing Ratio V004 (ML2CH3OH) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — At this time it is recommended that these data not be used pending further validation.ML2CH3OH is the EOS Aura Microwave Limb Sounder (MLS) standard product for...

  11. MLS/Aura Level 3 Bromine Monoxide (BrO) Daily 10degrees Lat Zonal Mean V004 (ML3DZMBRO) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML3DZMBRO is the EOS Aura Microwave Limb Sounder (MLS) daily zonal mean product for bromine monoxide derived from radiances measured by the 640 GHz radiometer. The...

  12. MLS/Aura Near-Real-Time L2 Sulfur Dioxide (SO2) Mixing Ratio V003 (ML2SO2_NRT) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2SO2_NRT is the EOS Aura Microwave Limb Sounder (MLS) Near-Real-Time (NRT) product for sulfur dioxide (SO2). This product contains daily SO2 profiles derived from...

  13. Preparation of hypoxic imaging agents 99Tcm-MNLS and 99Tcm-MLS and their biodistribution in mice

    International Nuclear Information System (INIS)

    Zha Zhihao; Wang Jianjun; Zhu Lin

    2009-01-01

    To develop 99 Tc m labeled hypoxic agents,two phosphate-based chelating agents were coupled to metronidazole, 2- (2-methyl-5-nitro-1H-imidazol-1-yl) ethyl dihydrogen phosphate (MNLS) and its analog 2- (2-methyl-1H-imidazol-1-yl) ethyl dihydrogen phosphate (MLS) were synthesized based on the mechanism of prodrug. Labeling yield of these 99 Tc m complexes were more than 90% as proved by TLC. Paper electrophoresis showed that these complexes were neutral. Biodistribution of these complexes in tumor-bearing mice showed that the uptake of 99 Tc m -MNLS (120 min, 2.99 ± 0.25 ID%/g) in tumor was higher than that of 99 Tc m -HL91 (120 min, 0.93 ± 0.13 ID%/g) and 99 Tc m -MLS (120 min, 1.61 ± 0.13 ID%/g), and the uptake ratio of tumor to muscle and tumor to liver of 99 Tc m -MNLS (120 min, 5.90, 1.03) were higher than that of 99 Tc m -HL91 (120 min, 3.59, 0.17) and 99 Tc m -MLS (120 min, 5.40, 0.13). The higher tumor uptake for 99 Tc m -MNLS than 99 Tc m -MLS suggested that nitroimidazole was a key group for tumor accumulation. 99 Tc m -MNLS had higher tumor uptake and lower liver uptake, which had the potential for tumor imaging and was worth of further vestigation. (authors)

  14. MLS measurements of stratospheric hydrogen cyanide during the 2015-2016 El Niño event

    Science.gov (United States)

    Pumphrey, Hugh C.; Glatthor, Norbert; Bernath, Peter F.; Boone, Christopher D.; Hannigan, James W.; Ortega, Ivan; Livesey, Nathaniel J.; Read, William G.

    2018-01-01

    It is known from ground-based measurements made during the 1982-1983 and 1997-1998 El Niño events that atmospheric hydrogen cyanide (HCN) tends to be higher during such years than at other times. The Microwave Limb Sounder (MLS) on the Aura satellite has been measuring HCN mixing ratios since launch in 2004; the measurements are ongoing at the time of writing. The winter of 2015-2016 saw the largest El Niño event since 1997-1998. We present MLS measurements of HCN in the lower stratosphere for the Aura mission to date, comparing the 2015-2016 El Niño period to the rest of the mission. HCN in 2015-2016 is higher than at any other time during the mission, but ground-based measurements suggest that it may have been even more elevated in 1997-1998. As the MLS HCN data are essentially unvalidated, we show them alongside data from the MIPAS and ACE-FTS instruments; the three instruments agree reasonably well in the tropical lower stratosphere. Global HCN emissions calculated from the Global Fire Emissions Database (GFED v4.1) database are much greater during large El Niño events and are greater in 1997-1998 than in 2015-2016, thereby showing good qualitative agreement with the measurements. Correlation between El Niño-Southern Oscillation (ENSO) indices, measured HCN, and GFED HCN emissions is less clear if the 2015-2016 event is excluded. In particular, the 2009-2010 winter had fairly strong El Niño conditions and fairly large GFED HCN emissions, but very little effect is observed in the MLS HCN.

  15. Eureka, 80° N, SKiYMET meteor radar temperatures compared with Aura MLS values

    Directory of Open Access Journals (Sweden)

    C. E. Meek

    2013-07-01

    Full Text Available The meteor trail echo decay rates are analysed on-site to provide daily temperatures near 90 km. In order to get temperatures from trail decay times, either knowledge of the pressure or the background temperature height gradient near 90 km is required (Hocking, 1999. Hocking et al. (2004 have developed an empirical 90 km temperature gradient model depending only on latitude and time of year, which is used in the SKiYMET on-site meteor temperature analysis. Here we look at the sensitivity of the resulting temperature to the assumed gradient and compare it and the temperatures with daily AuraMLS averages near Eureka. Generally there is good agreement between radar and satellite for winter temperatures and their short-term variations. However there is a major difference in mid-summer both in the temperatures and the gradients. Increased turbulence in summer, which may overwhelm the ambipolar diffusion even at 90 km, is likely a major factor. These differences are investigated by generating ambipolar-controlled decay times from satellite pressure and temperature data at a range of heights and comparing with radar measurements. Our study suggests it may be possible to use these data to estimate eddy diffusion coefficients at heights below 90 km. Finally the simple temperature analysis (using satellite pressures, and a standard meteor wind analysis are used to compare mean diurnal variations of temperature (T with those of zonal wind (U and meridional wind (V in composite multi-year monthly intervals.

  16. Polar Vortex Conditions during the 1995-96 Artic Winter: Meteorology and MLS Ozone

    Science.gov (United States)

    Manney, G. L.; Santee, M. L.; Froidevaux, L.; Waters, J. W.; Zurek, R. W.

    1996-01-01

    The 1995-96 northern hemisphere (NH) 205 winter stratosphere was colder than in any of the previous 17 winters, with lower stratospheric temperatures continuously below the type 1 (primarily HN03) polar stratospheric cloud (PSC) threshold for over 2 1/2 months. Upper tropospheric ridges in late Feb and early Mar 1996 led to the lowest observed NH lower stratospheric temperatures, and the latest observed NH temperatures below the type 2 (water ice) PSC threshold. Consistent with the unusual cold and chemical processing on PSCS, Upper Atmosphere Research Satellite (UARS) MLS observed a greater decrease in lower stratospheric ozone (03) in 1995-96 than in any of the previous 4 NH winters. 03 decreased throughout the vortex over an altitude range nearly as large as that typical of the southern hemisphere (SH). The decrease between late Dec 1995 and early Mar 1996 was about 2/3 of that over the equivalent SH period. As in other NH winters, temperatures in 1996 rose above the PSC threshold before the spring equinox, ending chemical processing in the NH vortex much earlier than is usual in the SH. A downward trend in column 03 above 100 hPa during Jan and Feb 1996 appears to be related to the lower stratospheric 03 depletion.

  17. Morphological Operations to Extract Urban Curbs in 3D MLS Point Clouds

    Directory of Open Access Journals (Sweden)

    Borja Rodríguez-Cuenca

    2016-06-01

    Full Text Available Automatic curb detection is an important issue in road maintenance, three-dimensional (3D urban modeling, and autonomous navigation fields. This paper is focused on the segmentation of curbs and street boundaries using a 3D point cloud captured by a mobile laser scanner (MLS system. Our method provides a solution based on the projection of the measured point cloud on the XY plane. Over that plane, a segmentation algorithm is carried out based on morphological operations to determine the location of street boundaries. In addition, a solution to extract curb edges based on the roughness of the point cloud is proposed. The proposed method is valid in both straight and curved road sections and applicable both to laser scanner and stereo vision 3D data due to the independence of its scanning geometry. The proposed method has been successfully tested with two datasets measured by different sensors. The first dataset corresponds to a point cloud measured by a TOPCON sensor in the Spanish town of Cudillero. The second dataset corresponds to a point cloud measured by a RIEGL sensor in the Austrian town of Horn. The extraction method provides completeness and correctness rates above 90% and quality values higher than 85% in both studied datasets.

  18. Polar stratospheric cloud evolution and chlorine activation measured by CALIPSO and MLS, and modeled by ATLAS

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    H. Nakajima

    2016-03-01

    Full Text Available We examined observations of polar stratospheric clouds (PSCs by CALIPSO, and of HCl and ClO by MLS along air mass trajectories, to investigate the dependence of the inferred PSC composition on the temperature history of the air parcels and the dependence of the level of chlorine activation on PSC composition. Several case studies based on individual trajectories from the Arctic winter 2009/2010 were conducted, with the trajectories chosen such that the first processing of the air mass by PSCs in this winter occurred on the trajectory. Transitions of PSC composition classes were observed to be highly dependent on the temperature history. In cases of a gradual temperature decrease, nitric acid trihydrate (NAT and super-cooled ternary solution (STS mixture clouds were observed. In cases of rapid temperature decrease, STS clouds were first observed, followed by NAT/STS mixture clouds. When temperatures dropped below the frost point, ice clouds formed and then transformed into NAT/STS mixture clouds when temperature increased above the frost point. The threshold temperature for rapid chlorine activation on PSCs is approximately 4 K below the NAT existence temperature, TNAT. Furthermore, simulations of the ATLAS chemistry and transport box model along the trajectories were used to corroborate the measurements and show good agreement with the observations. Rapid chlorine activation was observed when an air mass encountered PSCs. Usually, chlorine activation was limited by the amount of available ClONO2. Where ClONO2 was not the limiting factor, a large dependence on temperature was evident.

  19. Variability in the Speed of the Brewer-Dobson Circulation as Observed by Aura/MLS

    Science.gov (United States)

    Flury, Thomas; Wu, Dong L.; Read, W. G.

    2013-01-01

    We use Aura/MLS stratospheric water vapour (H2O) measurements as tracer for dynamics and infer interannual variations in the speed of the Brewer-Dobson circulation (BDC) from 2004 to 2011. We correlate one-year time series of H2O in the lower stratosphere at two subsequent pressure levels (68 hPa, approx.18.8 km and 56 hPa, approx 19.9 km at the Equator) and determine the time lag for best correlation. The same calculation is made on the horizontal on the 100 hPa (approx 16.6 km) level by correlating the H2O time series at the Equator with the ones at 40 N and 40 S. From these lag coefficients we derive the vertical and horizontal speeds of the BDC in the tropics and extra-tropics, respectively. We observe a clear interannual variability of the vertical and horizontal branch. The variability reflects signatures of the Quasi Biennial Oscillation (QBO). Our measurements confirm the QBO meridional circulation anomalies and show that the speed variations in the two branches of the BDC are out of phase and fairly well anti-correlated. Maximum ascent rates are found during the QBO easterly phase. We also find that transport of H2O towards the Northern Hemisphere (NH) is on the average two times faster than to the Southern Hemisphere (SH) with a mean speed of 1.15m/s at 100 hPa. Furthermore, the speed towards the NH shows much more interannual variability with an amplitude of about 21% whilst the speed towards the SH varies by only 10 %. An amplitude of 21% is also observed in the variability of the ascent rate at the Equator which is on the average 0.2mm/s.

  20. A cloud-ozone data product from Aura OMI and MLS satellite measurements

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    J. R. Ziemke

    2017-11-01

    Full Text Available Ozone within deep convective clouds is controlled by several factors involving photochemical reactions and transport. Gas-phase photochemical reactions and heterogeneous surface chemical reactions involving ice, water particles, and aerosols inside the clouds all contribute to the distribution and net production and loss of ozone. Ozone in clouds is also dependent on convective transport that carries low-troposphere/boundary-layer ozone and ozone precursors upward into the clouds. Characterizing ozone in thick clouds is an important step for quantifying relationships of ozone with tropospheric H2O, OH production, and cloud microphysics/transport properties. Although measuring ozone in deep convective clouds from either aircraft or balloon ozonesondes is largely impossible due to extreme meteorological conditions associated with these clouds, it is possible to estimate ozone in thick clouds using backscattered solar UV radiation measured by satellite instruments. Our study combines Aura Ozone Monitoring Instrument (OMI and Microwave Limb Sounder (MLS satellite measurements to generate a new research product of monthly-mean ozone concentrations in deep convective clouds between 30° S and 30° N for October 2004–April 2016. These measurements represent mean ozone concentration primarily in the upper levels of thick clouds and reveal key features of cloud ozone including: persistent low ozone concentrations in the tropical Pacific of  ∼ 10 ppbv or less; concentrations of up to 60 pphv or greater over landmass regions of South America, southern Africa, Australia, and India/east Asia; connections with tropical ENSO events; and intraseasonal/Madden–Julian oscillation variability. Analysis of OMI aerosol measurements suggests a cause and effect relation between boundary-layer pollution and elevated ozone inside thick clouds over landmass regions including southern Africa and India/east Asia.

  1. A cloud-ozone data product from Aura OMI and MLS satellite measurements

    Science.gov (United States)

    Ziemke, Jerald R.; Strode, Sarah A.; Douglass, Anne R.; Joiner, Joanna; Vasilkov, Alexander; Oman, Luke D.; Liu, Junhua; Strahan, Susan E.; Bhartia, Pawan K.; Haffner, David P.

    2017-11-01

    Ozone within deep convective clouds is controlled by several factors involving photochemical reactions and transport. Gas-phase photochemical reactions and heterogeneous surface chemical reactions involving ice, water particles, and aerosols inside the clouds all contribute to the distribution and net production and loss of ozone. Ozone in clouds is also dependent on convective transport that carries low-troposphere/boundary-layer ozone and ozone precursors upward into the clouds. Characterizing ozone in thick clouds is an important step for quantifying relationships of ozone with tropospheric H2O, OH production, and cloud microphysics/transport properties. Although measuring ozone in deep convective clouds from either aircraft or balloon ozonesondes is largely impossible due to extreme meteorological conditions associated with these clouds, it is possible to estimate ozone in thick clouds using backscattered solar UV radiation measured by satellite instruments. Our study combines Aura Ozone Monitoring Instrument (OMI) and Microwave Limb Sounder (MLS) satellite measurements to generate a new research product of monthly-mean ozone concentrations in deep convective clouds between 30° S and 30° N for October 2004-April 2016. These measurements represent mean ozone concentration primarily in the upper levels of thick clouds and reveal key features of cloud ozone including: persistent low ozone concentrations in the tropical Pacific of ˜ 10 ppbv or less; concentrations of up to 60 pphv or greater over landmass regions of South America, southern Africa, Australia, and India/east Asia; connections with tropical ENSO events; and intraseasonal/Madden-Julian oscillation variability. Analysis of OMI aerosol measurements suggests a cause and effect relation between boundary-layer pollution and elevated ozone inside thick clouds over landmass regions including southern Africa and India/east Asia.

  2. Tropospheric Column Ozone Response to ENSO in GEOS-5 Assimilation of OMI and MLS Ozone Data

    Science.gov (United States)

    Olsen, Mark A.; Wargan, Krzysztof; Pawson, Steven

    2016-01-01

    We use GEOS-5 analyses of Ozone Monitoring Instrument (OMI) and Microwave Limb Sounder (MLS) ozone observations to investigate the magnitude and spatial distribution of the El Nino Southern Oscillation (ENSO) influence on tropospheric column ozone (TCO) into the middle latitudes. This study provides the first explicit spatially resolved characterization of the ENSO influence and demonstrates coherent patterns and teleconnections impacting the TCO in the extratropics. The response is evaluated and characterized by both the variance explained and sensitivity of TCO to the Nino 3.4 index. The tropospheric response in the tropics agrees well with previous studies and verifies the analyses. A two-lobed response symmetric about the Equator in the western Pacific/Indonesian region seen in some prior studies and not in others is confirmed here. This two-lobed response is consistent with the large-scale vertical transport. We also find that the large-scale transport in the tropics dominates the response compared to the small-scale convective transport. The ozone response is weaker in the middle latitudes, but a significant explained variance of the TCO is found over several small regions, including the central United States. However, the sensitivity of TCO to the Nino 3.4 index is statistically significant over a large area of the middle latitudes. The sensitivity maxima and minima coincide with anomalous anti-cyclonic and cyclonic circulations where the associated vertical transport is consistent with the sign of the sensitivity. Also, ENSO related changes to the mean tropopause height can contribute significantly to the midlatitude response. Comparisons to a 22-year chemical transport model simulation demonstrate that these results from the 9- year assimilation are representative of the longer term. This investigation brings insight to several seemingly disparate prior studies of the El Nino influence on tropospheric ozone in the middle latitudes.

  3. Monitoring the distribution of tropospheric ozone concentration over Pakistan by using OMI/MLS satellite observations

    Science.gov (United States)

    Noreen, Asma; Fahim Khokhar, Muhammad; Murtaza, Rabbia; Zeb, Naila

    2016-07-01

    Pakistan is a semi-arid, agricultural country located in Indian Sub-continent, Asia. Due to exponential population growth, poor control and regulatory measures and practices in industries, it is facing a major problem of air pollution. The concentration of greenhouse gases and aerosols are showing an increasing trend in general. One of these greenhouse gases is tropospheric ozone, one of the criteria pollutant, which has a radiative forcing (RF) of about 0.4 ± 0.2 Wm-2, contributing about 14% of the present total RF. Spatial distribution and temporal evolution of tropospheric ozone concentration over Pakistan during 2004 to 2014 was studied by using combined OMI/MLS product, which was derived by tropospheric ozone residual (TOR) method. Results showed an overall increase of 3.2 ± 2.2 DU in tropospheric ozone concentration over Pakistan since October 2004. The mean spatial distribution showed high concentrations of ozone in the Punjab and southern Sindh where there is high population densities along with rapid urbanization and enhanced anthropogenic activities. The seasonal variations were observed in the provinces of the country and TO3 VCDs were found to be high during summer while minimum during winter. The statistical analysis by using seasonal Mann Kendal test also showed strong positive trends over the four provinces as well as in major cities of Pakistan. These variations were driven by various factors such as seasonality in UV-B fluxes, seasonality in ozone precursor gases such as NOx and VOCs and agricultural fire activities in Pakistan. A strong correlation of 97% was found between fire events and tropospheric ozone concentration over the country. The results also depicted the influence of UV-B radiations on the tropospheric ozone concentration over different regions of Pakistan especially in Baluchistan and Sindh provinces.

  4. Summer planetary-scale oscillations: aura MLS temperature compared with ground-based radar wind

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    C. E. Meek

    2009-04-01

    Full Text Available The advent of satellite based sampling brings with it the opportunity to examine virtually any part of the globe. Aura MLS mesospheric temperature data are analysed in a wavelet format for easy identification of possible planetary waves (PW and aliases masquerading as PW. A calendar year, 2005, of eastward, stationary, and westward waves at a selected latitude is shown in separate panels for wave number range −3 to +3 for period range 8 h to 30 days (d. Such a wavelet analysis is made possible by Aura's continuous sampling at all latitudes 82° S–82° N. The data presentation is suitable for examination of years of data. However this paper focuses on the striking feature of a "dish-shaped" upper limit to periods near 2 d in mid-summer, with longer periods appearing towards spring and fall, a feature also commonly seen in radar winds. The most probable cause is suggested to be filtering by the summer jet at 70–80 km, the latter being available from ground based medium frequency radar (MFR. Classically, the phase velocity of a wave must be greater than that of the jet in order to propagate through it. As an attempt to directly relate satellite and ground based sampling, a PW event of period 8d and wave number 2, which appears to be the original rather than an alias, is compared with ground based radar wind data. An appendix discusses characteristics of satellite data aliases with regard to their periods and amplitudes.

  5. The Contributions of Chemistry and Transport to Low Arctic Ozone in March 2011 Derived from Aura MLS Observations

    Science.gov (United States)

    Strahan, S. E.; Douglass, A. R.; Newman, P. A.

    2012-01-01

    Stratospheric and total columns of Arctic O3 (63-90 N) in late March 2011 averaged 320 and 349 DU, respectively. These values are 74 DU lower than averages for the previous 6 years. We use Aura MLS O3 observations to quantify the roles of chemistry and transport and find there are two major reasons for low O3 in March 2011: heterogeneous chemical loss and a late final warming that delayed the resupply of O3 until April. Daily vortex-averaged partial columns in the lowermost stratosphere (p greater than 133 hPa) and middle stratosphere (p less than 29 hPa) are unaffected by local heterogeneous chemistry and show a near total lack of transport into the vortex between late January and late March, contributing to the observed low column. The lower stratospheric (LS) column (133-29 hPa) is affected by both heterogeneous chemistry and transport. Low interannual variability of Aura MLS 0 3 columns and temperature inside the Arctic vortex (2004-2011) shows that the transport contribution to vortex O3 in fall and early winter is nearly the same each year. The descent of MLS N2O vortex profiles in 2011 provides an estimate of O3 transported into the LS column during late winter. By quantifying the role of transport we determine that PSC-driven chemical loss causes 80 (plus or minus 10) DU of vortex-averaged O3 loss by late March 2011. Without heterogeneous chemical loss, March 2011 vortex O3 would have been 40 DU lower than normal due to the late final warming and resupply of O3 which did not occur until April.

  6. The Nkx5/HMX homeodomain protein MLS-2 is required for proper tube cell shape in the C. elegans excretory system.

    Science.gov (United States)

    Abdus-Saboor, Ishmail; Stone, Craig E; Murray, John I; Sundaram, Meera V

    2012-06-15

    Cells perform wide varieties of functions that are facilitated, in part, by adopting unique shapes. Many of the genes and pathways that promote cell fate specification have been elucidated. However, relatively few transcription factors have been identified that promote shape acquisition after fate specification. Here we show that the Nkx5/HMX homeodomain protein MLS-2 is required for cellular elongation and shape maintenance of two tubular epithelial cells in the C. elegans excretory system, the duct and pore cells. The Nkx5/HMX family is highly conserved from sea urchins to humans, with known roles in neuronal and glial development. MLS-2 is expressed in the duct and pore, and defects in mls-2 mutants first arise when the duct and pore normally adopt unique shapes. MLS-2 cooperates with the EGF-Ras-ERK pathway to turn on the LIN-48/Ovo transcription factor in the duct cell during morphogenesis. These results reveal a novel interaction between the Nkx5/HMX family and the EGF-Ras pathway and implicate a transcription factor, MLS-2, as a regulator of cell shape. Copyright © 2012 Elsevier Inc. All rights reserved.

  7. MLS-Net and SecureParser®: A New Method for Securing and Segregating Network Data

    Directory of Open Access Journals (Sweden)

    Robert A. Johnson

    2008-10-01

    Full Text Available A new method of network security and virtualization is presented which allows the consolidation of multiple network infrastructures dedicated to single security levels or communities of interest onto a single, virtualized network. An overview of the state of the art of network security protocols is presented, including the use of SSL, IPSec, and HAIPE IS, followed by a discussion of the SecureParser® technology and MLS-Net architecture, which in combination allow the virtualization of local network enclaves.

  8. Navigation and flight director guidance for the NASA/FAA helicopter MLS curved approach flight test program

    Science.gov (United States)

    Phatak, A. V.; Lee, M. G.

    1985-01-01

    The navigation and flight director guidance systems implemented in the NASA/FAA helicopter microwave landing system (MLS) curved approach flight test program is described. Flight test were conducted at the U.S. Navy's Crows Landing facility, using the NASA Ames UH-lH helicopter equipped with the V/STOLAND avionics system. The purpose of these tests was to investigate the feasibility of flying complex, curved and descending approaches to a landing using MLS flight director guidance. A description of the navigation aids used, the avionics system, cockpit instrumentation and on-board navigation equipment used for the flight test is provided. Three generic reference flight paths were developed and flown during the test. They were as follows: U-Turn, S-turn and Straight-In flight profiles. These profiles and their geometries are described in detail. A 3-cue flight director was implemented on the helicopter. A description of the formulation and implementation of the flight director laws is also presented. Performance data and analysis is presented for one pilot conducting the flight director approaches.

  9. Semantic Labelling of Ultra Dense Mls Point Clouds in Urban Road Corridors Based on Fusing Crf with Shape Priors

    Science.gov (United States)

    Yao, W.; Polewski, P.; Krzystek, P.

    2017-09-01

    In this paper, a labelling method for the semantic analysis of ultra-high point density MLS data (up to 4000 points/m2) in urban road corridors is developed based on combining a conditional random field (CRF) for the context-based classification of 3D point clouds with shape priors. The CRF uses a Random Forest (RF) for generating the unary potentials of nodes and a variant of the contrastsensitive Potts model for the pair-wise potentials of node edges. The foundations of the classification are various geometric features derived by means of co-variance matrices and local accumulation map of spatial coordinates based on local neighbourhoods. Meanwhile, in order to cope with the ultra-high point density, a plane-based region growing method combined with a rule-based classifier is applied to first fix semantic labels for man-made objects. Once such kind of points that usually account for majority of entire data amount are pre-labeled; the CRF classifier can be solved by optimizing the discriminative probability for nodes within a subgraph structure excluded from pre-labeled nodes. The process can be viewed as an evidence fusion step inferring a degree of belief for point labelling from different sources. The MLS data used for this study were acquired by vehicle-borne Z+F phase-based laser scanner measurement, which permits the generation of a point cloud with an ultra-high sampling rate and accuracy. The test sites are parts of Munich City which is assumed to consist of seven object classes including impervious surfaces, tree, building roof/facade, low vegetation, vehicle and pole. The competitive classification performance can be explained by the diverse factors: e.g. the above ground height highlights the vertical dimension of houses, trees even cars, but also attributed to decision-level fusion of graph-based contextual classification approach with shape priors. The use of context-based classification methods mainly contributed to smoothing of labelling by removing

  10. SEMANTIC LABELLING OF ULTRA DENSE MLS POINT CLOUDS IN URBAN ROAD CORRIDORS BASED ON FUSING CRF WITH SHAPE PRIORS

    Directory of Open Access Journals (Sweden)

    W. Yao

    2017-09-01

    Full Text Available In this paper, a labelling method for the semantic analysis of ultra-high point density MLS data (up to 4000 points/m2 in urban road corridors is developed based on combining a conditional random field (CRF for the context-based classification of 3D point clouds with shape priors. The CRF uses a Random Forest (RF for generating the unary potentials of nodes and a variant of the contrastsensitive Potts model for the pair-wise potentials of node edges. The foundations of the classification are various geometric features derived by means of co-variance matrices and local accumulation map of spatial coordinates based on local neighbourhoods. Meanwhile, in order to cope with the ultra-high point density, a plane-based region growing method combined with a rule-based classifier is applied to first fix semantic labels for man-made objects. Once such kind of points that usually account for majority of entire data amount are pre-labeled; the CRF classifier can be solved by optimizing the discriminative probability for nodes within a subgraph structure excluded from pre-labeled nodes. The process can be viewed as an evidence fusion step inferring a degree of belief for point labelling from different sources. The MLS data used for this study were acquired by vehicle-borne Z+F phase-based laser scanner measurement, which permits the generation of a point cloud with an ultra-high sampling rate and accuracy. The test sites are parts of Munich City which is assumed to consist of seven object classes including impervious surfaces, tree, building roof/facade, low vegetation, vehicle and pole. The competitive classification performance can be explained by the diverse factors: e.g. the above ground height highlights the vertical dimension of houses, trees even cars, but also attributed to decision-level fusion of graph-based contextual classification approach with shape priors. The use of context-based classification methods mainly contributed to smoothing of

  11. The high Arctic in extreme winters: vortex, temperature, and MLS and ACE-FTS trace gas evolution

    Directory of Open Access Journals (Sweden)

    G. L. Manney

    2008-02-01

    Full Text Available The first three Arctic winters of the ACE mission represented two extremes of winter variability: Stratospheric sudden warmings (SSWs in 2004 and 2006 were among the strongest, most prolonged on record; 2005 was a record cold winter. Canadian Arctic Atmospheric Chemistry Experiment (ACE Validation Campaigns were conducted at Eureka (80° N, 86° W during each of these winters. New satellite measurements from ACE-Fourier Transform Spectrometer (ACE-FTS, Sounding of the Atmosphere using Broadband Emission Radiometry (SABER, and Aura Microwave Limb Sounder (MLS, along with meteorological analyses and Eureka lidar temperatures, are used to detail the meteorology in these winters, to demonstrate its influence on transport, and to provide a context for interpretation of ACE-FTS and validation campaign observations. During the 2004 and 2006 SSWs, the vortex broke down throughout the stratosphere, reformed quickly in the upper stratosphere, and remained weak in the middle and lower stratosphere. The stratopause reformed at very high altitude, near 75 km. ACE measurements covered both vortex and extra-vortex conditions in each winter, except in late-February through mid-March 2004 and 2006, when the strong, pole-centered vortex that reformed after the SSWs resulted in ACE sampling only inside the vortex in the middle through upper stratosphere. The 2004 and 2006 Eureka campaigns were during the recovery from the SSWs, with the redeveloping vortex over Eureka. 2005 was the coldest winter on record in the lower stratosphere, but with an early final warming in mid-March. The vortex was over Eureka at the start of the 2005 campaign, but moved away as it broke up. Disparate temperature profile structure and vortex evolution resulted in much lower (higher temperatures in the upper (lower stratosphere in 2004 and 2006 than in 2005. Satellite temperatures agree well with lidar data up to 50–60 km, and ACE-FTS, MLS and SABER show good agreement in high

  12. The HMX/NKX homeodomain protein MLS-2 specifies the identity of the AWC sensory neuron type via regulation of the ceh-36 Otx gene in C. elegans

    Science.gov (United States)

    Kim, Kyuhyung; Kim, Rinho; Sengupta, Piali

    2010-01-01

    The differentiated features of postmitotic neurons are dictated by the expression of specific transcription factors. The mechanisms by which the precise spatiotemporal expression patterns of these factors are regulated are poorly understood. In C. elegans, the ceh-36 Otx homeobox gene is expressed in the AWC sensory neurons throughout postembryonic development, and regulates terminal differentiation of this neuronal subtype. Here, we show that the HMX/NKX homeodomain protein MLS-2 regulates ceh-36 expression specifically in the AWC neurons. Consequently, the AWC neurons fail to express neuron type-specific characteristics in mls-2 mutants. mls-2 is expressed transiently in postmitotic AWC neurons, and directly initiates ceh-36 expression. CEH-36 subsequently interacts with a distinct site in its cis-regulatory sequences to maintain its own expression, and also directly regulates the expression of AWC-specific terminal differentiation genes. We also show that MLS-2 acts in additional neuron types to regulate their development and differentiation. Our analysis describes a transcription factor cascade that defines the unique postmitotic characteristics of a sensory neuron subtype, and provides insights into the spatiotemporal regulatory mechanisms that generate functional diversity in the sensory nervous system. PMID:20150279

  13. Clinical spectrum of females with HCCS mutation: from no clinical signs to a neonatal lethal form of the microphthalmia with linear skin defects (MLS) syndrome

    NARCIS (Netherlands)

    van Rahden, V.A.; Rau, I.; Fuchs, S.; Kosyna, F.K.; de Almeida, H.L.; Fryssira, H.; Isidor, B.; Jauch, A.; Joubert, M.; Lachmeijer, A.M.A.; Zweier, C.; Moog, U.; Kutsche, K.

    2014-01-01

    Background: Segmental Xp22.2 monosomy or a heterozygous HCCS mutation is associated with the microphthalmia with linear skin defects (MLS) or MIDAS (microphthalmia, dermal aplasia, and sclerocornea) syndrome, an X-linked disorder with male lethality. HCCS encodes the holocytochrome c-type synthase

  14. MLS/Aura Near-Real-Time L2 Water Vapor (H2O) Mixing Ratio V004 (ML2H2O_NRT) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — ML2H2O_NRT is the EOS Aura Microwave Limb Sounder (MLS) Near-Real-Time (NRT) product for water vapor (H2O). This product contains H2O profiles derived from the 190...

  15. Progress in creating trend quality ozone profiles from OMPS LP to continue NASA SAGE and Aura MLS ozone records

    Science.gov (United States)

    Kramarova, N. A.; Bhartia, P. K.; Jaross, G.; Moy, L.; Seftor, C. J.; Frith, S. M.

    2017-12-01

    The Limb Profiler (LP) is a part of the Ozone Mapping and Profiler Suite launched aboard the Suomi NPP satellite. The LP measures solar scattered radiation from the atmospheric limb in the UV and visible spectral ranges to retrieve ozone profiles. Recently, LP measurements spanning more than 5+ years have been processed with the new NASA GSFC version 2.5 Limb ozone retrieval algorithm. The LP record is intended to continue NASA high resolution ozone profiles from SAGE I/II and Aura MLS missions. However, uncertainties in LP' altitude registration, imposed by the instrument design, must be well characterized in order to use LP data for the trend analysis. Two methods were applied to resolve the LP altitude registration with combined uncertainties of ±200 m. These methods have revealed subtle variations in spacecraft attitude along the orbit and with time, including variations in altitude registration due to thermal distortions of the instrument focal plane. These results give us confidence that we can maintain LP altitude registration accurately. To validate our internal altitude registration methods we compare LP ozone retrievals in the upper stratosphere with MLS and OMPS NP ozone measurements. Our comparisons have also revealed subtle systematic errors in measuring radiances that vary along the rows and columns of the Charge Coupled Device (CCD). Some of these errors are probably caused by small shifts in instrument wavelength registration, while others may be due to variations in CCD sensitivity. Understanding and removing these differences is a high priority of the LP Core Team. However, not all of the differences between LP and other instruments are necessarily due to errors in LP data. We will show comparisons with other instruments and discuss some of the issues that remain unresolved.

  16. Comparison of ozone profiles from DIAL, MLS, and chemical transport model simulations over Río Gallegos, Argentina, during the spring Antarctic vortex breakup, 2009

    Science.gov (United States)

    Sugita, Takafumi; Akiyoshi, Hideharu; Wolfram, Elián; Salvador, Jacobo; Ohyama, Hirofumi; Mizuno, Akira

    2017-12-01

    This study evaluates the agreement between ozone profiles derived from the ground-based differential absorption lidar (DIAL), satellite-borne Aura Microwave Limb Sounder (MLS), and 3-D chemical transport model (CTM) simulations such as the Model for Interdisciplinary Research on Climate (MIROC-CTM) over the Atmospheric Observatory of Southern Patagonia (Observatorio Atmosférico de la Patagonia Austral, OAPA; 51.6° S, 69.3° W) in Río Gallegos, Argentina, from September to November 2009. In this austral spring, measurements were performed in the vicinity of the polar vortex and inside it on some occasions; they revealed the variability in the potential vorticity (PV) of measured air masses. Comparisons between DIAL and MLS were performed between 6 and 100 hPa with 500 km and 24 h coincidence criteria. The results show a good agreement between DIAL and MLS with mean differences of ±0.1 ppmv (MLS - DIAL, n = 180) between 6 and 56 hPa. MIROC-CTM also agrees with DIAL, with mean differences of ±0.3 ppmv (MIROC-CTM - DIAL, n = 23) between 10 and 56 hPa. Both comparisons provide mean differences of 0.5 ppmv (MLS) to 0.8-0.9 ppmv (MIROC-CTM) at the 83-100 hPa levels. DIAL tends to underestimate ozone values at this lower altitude region. Between 6 and 8 hPa, the MIROC-CTM ozone value is 0.4-0.6 ppmv (5-8 %) smaller than those from DIAL. Applying the scaled PV (sPV) criterion for matching pairs in the DIAL-MLS comparison, the variability in the difference decreases 21-47 % between 10 and 56 hPa. However, the mean differences are small for all pressure levels, except 6 hPa. Because ground measurement sites in the Southern Hemisphere (SH) are very sparse at mid- to high latitudes, i.e., 35-60° S, the OAPA site is important for evaluating the bias and long-term stability of satellite instruments. The good performance of this DIAL system will be useful for such purposes in the future.

  17. A-train CALIOP and MLS observations of early winter Antarctic polar stratospheric clouds and nitric acid in 2008

    Directory of Open Access Journals (Sweden)

    A. Lambert

    2012-03-01

    Full Text Available A-train Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP and Microwave Limb Sounder (MLS observations are used to investigate the development of polar stratospheric clouds (PSCs and the gas-phase nitric acid distribution in the early 2008 Antarctic winter. Observational evidence of gravity-wave activity is provided by Atmospheric Infrared Sounder (AIRS radiances and infrared spectroscopic detection of nitric acid trihydrate (NAT in PSCs is obtained from the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS. Goddard Earth Observing System Data Assimilation System (GEOS-5 DAS analyses are used to derive Lagrangian trajectories and to determine temperature-time histories of air parcels. We use CALIOP backscatter and depolarization measurements to classify PSCs and the MLS measurements to determine the corresponding gas-phase HNO3 as a function of temperature. For liquid PSCs the uptake of HNO3 follows the theoretical equilibrium curve for supercooled ternary solutions (STS, but at temperatures about 1 K lower as determined from GEOS-5. In the presence of solid phase PSCs, above the ice frost-point, the HNO3 depletion occurs over a wider range of temperatures (+2 to −7 K distributed about the NAT equilibrium curve. Rapid gas-phase HNO3 depletion is first seen by MLS from from 23–25 May 2008, consisting of a decrease in the volume mixing ratio from 14 ppbv (parts per billion by volume to 7 ppbv on the 46–32 hPa (hectopascal pressure levels and accompanied by a 2–3 ppbv increase by renitrification at the 68 hPa pressure level. The observed region of depleted HNO3 is substantially smaller than the region bounded by the NAT existence temperature threshold. Temperature-time histories of air parcels demonstrate that the depletion is more clearly correlated with prior exposure to temperatures a few kelvin above the frost-point. From the combined data we infer the presence

  18. Interannual variations of early winter Antarctic polar stratospheric cloud formation and nitric acid observed by CALIOP and MLS

    Science.gov (United States)

    Lambert, Alyn; Santee, Michelle L.; Livesey, Nathaniel J.

    2016-12-01

    We use satellite-borne measurements collected over the last decade (2006-2015) from the Aura Microwave Limb Sounder (MLS) and the Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) to investigate the nitric acid distribution and the properties of polar stratospheric clouds (PSCs) in the early winter Antarctic vortex. Frequently, at the very start of the winter, we find that synoptic-scale depletion of HNO3 can be detected in the inner vortex before the first lidar detection of geophysically associated PSCs. The generation of "sub-visible" PSCs can be explained as arising from the development of a solid particle population with low number densities and large particle sizes. Assumed to be composed of nitric acid trihydrate (NAT), the sub-visible PSCs form at ambient temperatures well above the ice frost point, but also above the temperature at which supercooled ternary solution (STS) grows out of the background supercooled binary solution (SBS) distribution. The temperature regime of their formation, inferred from the simultaneous uptake of ambient HNO3 into NAT and their Lagrangian temperature histories, is at a depression of a few kelvin with respect to the NAT existence threshold, TNAT. Therefore, their nucleation requires a considerable supersaturation of HNO3 over NAT, and is consistent with a recently described heterogeneous nucleation process on solid foreign nuclei immersed in liquid aerosol. We make a detailed investigation of the comparative limits of detection of PSCs and the resulting sequestration of HNO3 imposed by lidar, mid-infrared, and microwave techniques. We find that the temperature history of air parcels, in addition to the local ambient temperature, is an important factor in the relative frequency of formation of liquid/solid PSCs. We conclude that the initiation of NAT nucleation and the subsequent development of large NAT particles capable of sedimentation and denitrification in the early winter do not emanate from an ice

  19. Correlation among Cirrus Ice Content, Water Vapor and Temperature in the TTL as Observed by CALIPSO and Aura-MLS

    Science.gov (United States)

    Flury, T.; Wu, D. L.; Read, W. G.

    2012-01-01

    Water vapor in the tropical tropopause layer (TTL) has a local radiative cooling effect. As a source for ice in cirrus clouds, however, it can also indirectly produce infrared heating. Using NASA A-Train satellite measurements of CALIPSO and Aura/MLS we calculated the correlation of water vapor, ice water content and temperature in the TTL. We find that temperature strongly controls water vapor (correlation r =0.94) and cirrus clouds at 100 hPa (r = -0.91). Moreover we observe that the cirrus seasonal cycle is highly (r =-0.9) anticorrelated with the water vapor variation in the TTL, showing higher cloud occurrence during December-January-February. We further investigate the anticorrelation on a regional scale and find that the strong anticorrelation occurs generally in the ITCZ (Intertropical Convergence Zone). The seasonal cycle of the cirrus ice water content is also highly anticorrelated to water vapor (r = -0.91) and our results support the hypothesis that the total water at 100 hPa is roughly constant. Temperature acts as a main regulator for balancing the partition between water vapor and cirrus clouds. Thus, to a large extent, the depleting water vapor in the TTL during DJF is a manifestation of cirrus formation.

  20. Characteristics of Water Vapor in the UTLS over the Tibetan Plateau Based on AURA/MLS Observations

    Directory of Open Access Journals (Sweden)

    Yi Sun

    2017-01-01

    Full Text Available Water vapor (WV has a vital effect on global climate change. Using satellite data observed by AURA/MLS and ERA-Interim reanalysis datasets, the spatial distributions and temporal variations of WV were analyzed. It was found that high WV content in the UTLS over the southern Tibetan Plateau is more apparent in summer, due to monsoon-induced strong upward motions. The WV content showed the opposite distribution at 100 hPa, though, during spring and winter. And a different distribution at 121 hPa indicated that the difference in WV content between the northern and southern plateau occurs between 121 and 100 hPa in spring and between 147 and 121 hPa in winter. In the UTLS, it diminishes rapidly with increase in altitude in these two seasons, and it shows a “V” structure in winter. There has been a weak increasing trend in WV at 100 hPa, but a downtrend at 147 and 215 hPa, during the past 12 years. At the latter two heights, the WV content in summer has been much higher than in other seasons. Furthermore, WV variation showed a rough wave structure in spring and autumn at 215 hPa. The variation of WV over the Tibetan Plateau is helpful in understanding the stratosphere-troposphere exchange (STE and climate change.

  1. Evidence of Convective Redistribution of Carbon Monoxide in Aura Tropospheric Emission Sounder (TES) and Microwave Limb Sounder (MLS) Observations

    Science.gov (United States)

    Manyin, Michael; Douglass, Anne; Schoeberl, Mark

    2010-01-01

    Vertical convective transport is a key element of the tropospheric circulation. Convection lofts air from the boundary layer into the free troposphere, allowing surface emissions to travel much further, and altering the rate of chemical processes such as ozone production. This study uses satellite observations to focus on the convective transport of CO from the boundary layer to the mid and upper troposphere. Our hypothesis is that strong convection associated with high rain rate regions leads to a correlation between mid level and upper level CO amounts. We first test this hypothesis using the Global Modeling Initiative (GMI) chemistry and transport model. We find the correlation is robust and increases as the precipitation rate (the strength of convection) increases. We next examine three years of CO profiles from the Tropospheric Emission Sounder (TES) and Microwave Limb Sounder (MLS) instruments aboard EOS Aura. Rain rates are taken from the Tropical Rainfall Measuring Mission (TRMM) 3B-42 multi-satellite product. Again we find a correlation between mid-level and upper tropospheric CO, which increases with rain rate. Our result shows the critical importance of tropical convection in coupling vertical levels of the troposphere in the transport of trace gases. The effect is seen most clearly in strong convective regions such as the Inter-tropical Convergence Zone.

  2. Comparison of ozone profiles from DIAL, MLS, and chemical transport model simulations over Río Gallegos, Argentina, during the spring Antarctic vortex breakup, 2009

    Directory of Open Access Journals (Sweden)

    T. Sugita

    2017-12-01

    Full Text Available This study evaluates the agreement between ozone profiles derived from the ground-based differential absorption lidar (DIAL, satellite-borne Aura Microwave Limb Sounder (MLS, and 3-D chemical transport model (CTM simulations such as the Model for Interdisciplinary Research on Climate (MIROC-CTM over the Atmospheric Observatory of Southern Patagonia (Observatorio Atmosférico de la Patagonia Austral, OAPA; 51.6° S, 69.3° W in Río Gallegos, Argentina, from September to November 2009. In this austral spring, measurements were performed in the vicinity of the polar vortex and inside it on some occasions; they revealed the variability in the potential vorticity (PV of measured air masses. Comparisons between DIAL and MLS were performed between 6 and 100 hPa with 500 km and 24 h coincidence criteria. The results show a good agreement between DIAL and MLS with mean differences of ±0.1 ppmv (MLS − DIAL, n  =  180 between 6 and 56 hPa. MIROC-CTM also agrees with DIAL, with mean differences of ±0.3 ppmv (MIROC-CTM − DIAL, n  =  23 between 10 and 56 hPa. Both comparisons provide mean differences of 0.5 ppmv (MLS to 0.8–0.9 ppmv (MIROC-CTM at the 83–100 hPa levels. DIAL tends to underestimate ozone values at this lower altitude region. Between 6 and 8 hPa, the MIROC-CTM ozone value is 0.4–0.6 ppmv (5–8 % smaller than those from DIAL. Applying the scaled PV (sPV criterion for matching pairs in the DIAL–MLS comparison, the variability in the difference decreases 21–47 % between 10 and 56 hPa. However, the mean differences are small for all pressure levels, except 6 hPa. Because ground measurement sites in the Southern Hemisphere (SH are very sparse at mid- to high latitudes, i.e., 35–60° S, the OAPA site is important for evaluating the bias and long-term stability of satellite instruments. The good performance of this DIAL system will be useful for such purposes in the

  3. MIPAS reduced spectral resolution UTLS-1 mode measurements of temperature, O3, HNO3, N2O, H2O and relative humidity over ice: retrievals and comparison to MLS

    Directory of Open Access Journals (Sweden)

    M. L. Santee

    2009-07-01

    Full Text Available During several periods since 2005 the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS on Envisat has performed observations dedicated to the region of the upper troposphere/lower stratosphere (UTLS. For the duration of November/December 2005 global distributions of temperature and several trace gases from MIPAS UTLS-1 mode measurements have been retrieved using the IMK/IAA (Institut für Meteorologie und Klimaforschung/Instituto de Astrofísica de Andalucía scientific processor. In the UTLS region a vertical resolution of 3 km for temperaure, 3 to 4 km for H2O, 2.5 to 3 km for O3, 3.5 km for HNO3 and 3.5 to 2.5 km for N2O has been achieved. The retrieved temperature, H2O, O3, HNO3, N2O, and relative humidity over ice are intercompared with the Microwave Limb Sounder (MLS/Aura v2.2 data in the pressure range 316 to 0.68 hPa, 316 to 0.68 hPa, 215 to 0.68 hPa, 215 to 3.16 hPa, 100 to 1 hPa and 316 to 10 hPa, respectively. In general, MIPAS and MLS temperatures are biased within ±4 K over the whole pressure and latitude range. Systematic, latitude-independent differences of −2 to −4 K (MIPAS-MLS at 121 hPa are explained by previously observed biases in the MLS v2.2 temperature retrievals. Temperature differences of −4 K up to 12 K above 10.0 hPa are present both in MIPAS and MLS with respect to ECMWF (European Centre for Medium-Range Weather Forecasts and are likely due to deficiencies of the ECMWF analysis data. MIPAS and MLS stratospheric volume mixing ratios (vmr of H2O are biased within ±1 ppmv, with indication of oscillations between 146 and 26 hPa in the MLS dataset. Tropical upper tropospheric values of relative humidity over ice measured by the two instruments differ by ±20% in the pressure range ~146 to 68 hPa. These differences are mainly caused by the MLS temperature biases. Ozone mixing ratios agree within 0.5 ppmv (10 to 20% between 68 and 14 hPa. At pressures smaller than 10 hPa, MIPAS O3 vmr are higher than

  4. SYNERGISTIC EFFECTS OF ETHANOL MEDICINAL PLANT EXTRACTS WITH ERYTHROMYCIN AGAINST SKIN STRAINS OF STAPHYLOCOCCI WITH INDUCIBLE PHENOTYPE OF MLS-RESISTANCE

    Directory of Open Access Journals (Sweden)

    Yurchyshyn O.I.

    2017-10-01

    Full Text Available Introduction. One of the main ways to control microorganisms’ resistance to antibiotics is to find substances that are able to overcome it and potentiate antibiotics action, in particular to neutralize the antibiotic-inactivating enzymes or block the active efflux of antibiotic from microbial cells. Every year there is a growing interest in the therapeutic potential of herbal active compounds as modifiers of antibiotic resistance including MLS-resistance (macrolide-lincosamide-streptoramin B. It should be emphasized that a number of biologically active substances of plant origin can potentiate antimicrobial activity of erythromycin (ERY against MLS-resistant staphylococci. The present study was designed to investigate the antibacterial and synergistic effects of eight Ukrainian ethanol medicinal plant extracts with erythromycin against skin strains of staphylococci with inducible phenotype of MLS-resistance. Material & methods. S. aureus and S. epidermidis strains were tested for susceptibility to antibiotics of MLS-group by disk diffusion test. Effective antimicrobial concentrations of plant extracts and erythromycin were determined by two-fold serial dilution in nutrient agar and broth. Combinatory effects between organic extracts and ERY were assessed using the checkerboard assay against tested strains to evaluate culture growth in the presence of two antimicrobials with different concentrations. Results & discussion. The Alnus incana L. fruits extract was the most potent inhibitor against tested strains (MIC 40.625-162.5 µg/mL; while Geranium pratense L. rhizomes extract exhibited the least antimicrobial activity (MIC 650-2,600 µg/mL. The Alnus incana L. fruits extract and the Geranium pratense L. rhizomes extract showed synergistic effect with erythromycin against 100% strains of staphylococci (average FICI 0.028 – 0.057; p<0.001. In the presence of 1/4 MIC of ERY Alnus incana L. fruits extract antimicrobial concentration was

  5. Assessment and Applications of NASA Ozone Data Products Derived from Aura OMI-MLS Satellite Measurements in Context of the GMI Chemical Transport Model

    Science.gov (United States)

    Ziemke, J. R.; Olsen, M. A.; Witte, J. C.; Douglass, A. R.; Strahan, S. E.; Wargan, K.; Liu, X.; Schoeberl, M. R.; Yang, K.; Kaplan, T. B.; hide

    2013-01-01

    Measurements from the Ozone Monitoring Instrument (OMI) and Microwave Limb Sounder (MLS), both onboard the Aura spacecraft, have been used to produce daily global maps of column and profile ozone since August 2004. Here we compare and evaluate three strategies to obtain daily maps of tropospheric and stratospheric ozone from OMI and MLS measurements: trajectory mapping, direct profile retrieval, and data assimilation. Evaluation is based upon an assessment that includes validation using ozonesondes and comparisons with the Global Modeling Initiative (GMI) chemical transport model (CTM). We investigate applications of the three ozone data products from near-decadal and inter-annual timescales to day-to-day case studies. Zonally averaged inter-annual changes in tropospheric ozone from all of the products in any latitude range are of the order 1-2 Dobson Units while changes (increases) over the 8-year Aura record investigated http://eospso.gsfc.nasa.gov/atbd-category/49 vary approximately 2-4 Dobson Units. It is demonstrated that all of the ozone products can measure and monitor exceptional tropospheric ozone events including major forest fire and pollution transport events. Stratospheric ozone during the Aura record has several anomalous inter-annual events including stratospheric warming split events in the Northern Hemisphere extra-tropics that are well captured using the data assimilation ozone profile product. Data assimilation with continuous daily global coverage and vertical ozone profile information is the best of the three strategies at generating a global tropospheric and stratospheric ozone product for science applications.

  6. Feasibility of megavoltage portal CT using an electronic portal imaging device (EPID) and a multi-level scheme algebraic reconstruction technique (MLS-ART)

    International Nuclear Information System (INIS)

    Guan, Huaiqun; Zhu, Yunping

    1998-01-01

    Although electronic portal imaging devices (EPIDs) are efficient tools for radiation therapy verification, they only provide images of overlapped anatomic structures. We investigated using a fluorescent screen/CCD-based EPID, coupled with a novel multi-level scheme algebraic reconstruction technique (MLS-ART), for a feasibility study of portal computed tomography (CT) reconstructions. The CT images might be useful for radiation treatment planning and verification. We used an EPID, set it to work at the linear dynamic range and collimated 6 MV photons from a linear accelerator to a slit beam of 1 cm wide and 25 cm long. We performed scans under a total of ∼200 monitor units (MUs) for several phantoms in which we varied the number of projections and MUs per projection. The reconstructed images demonstrated that using the new MLS-ART technique megavoltage portal CT with a total of 200 MUs can achieve a contrast detectibility of ∼2.5% (object size 5mmx5mm) and a spatial resolution of 2.5 mm. (author)

  7. Mother and daughter with a terminal Xp deletion: implication of chromosomal mosaicism and X-inactivation in the high clinical variability of the microphthalmia with linear skin defects (MLS) syndrome.

    Science.gov (United States)

    Wimplinger, Isabella; Rauch, Anita; Orth, Ulrike; Schwarzer, Ulrich; Trautmann, Udo; Kutsche, Kerstin

    2007-01-01

    The microphthalmia with linear skin defects (MLS or MIDAS) syndrome is a rare X-linked dominant inherited disorder with male lethality, associated with segmental aneuploidy of the Xp22.2 region in most of the cases. However, we recently described heterozygous sequence alterations in a single gene, HCCS, in females with MLS. Beside the classical MLS phenotype, occasional features such as sclerocornea, agenesis of the corpus callosum, and congenital heart defects can occur. Although the majority of cases are sporadic, mother-to-daughter transmission has been observed and a high intra- and interfamilial phenotypic variability exists. We describe an asymptomatic mother and her daughter presenting with the typical features of MLS syndrome. By cytogenetic analysis both females were found to have a terminal Xp deletion with the breakpoint in Xp22.2, mapping near to or within the MSL3L1 gene which is located centromeric to HCCS. FISH analysis revealed that the mother is a mosaic with 45,X(11)/46,X,del(X)(p22.2)(89), while in all cells of the MLS-affected daughter a hybridization pattern consistent with a 46,X,del(X)(p22.2) karyotype was detected. By haplotype analysis we identified the paternal X chromosome of the mother to carry the terminal Xp deletion. X-inactivation studies showed a completely skewed pattern in mother and daughter with the deleted X chromosome to be preferentially inactivated in their peripheral blood cells. We suggest that both chromosomal mosaicism as well as functional X chromosome mosaicism could contribute to the lack of any typical MLS feature in individuals with a heterozygous MLS-associated mutation. The 45,X cell population, that most likely is also present in other tissues of the mother, might have protected her from developing MLS. Nonetheless, a non-random X-inactivation pattern in favor of activity of the wild-type X chromosome in the early blastocyte could also account for the apparent lack of any disease sign in this female.

  8. Characterization of Staphylococcus aureus Strains Isolated from Czech Cystic Fibrosis Patients: High Rate of Ribosomal Mutation Conferring Resistance to MLS(B) Antibiotics as a Result of Long-Term and Low-Dose Azithromycin Treatment.

    Science.gov (United States)

    Tkadlec, Jan; Vařeková, Eva; Pantůček, Roman; Doškař, Jiří; Růžičková, Vladislava; Botka, Tibor; Fila, Libor; Melter, Oto

    2015-08-01

    Staphylococcus aureus is one of the most frequent pathogens infecting the respiratory tract of patients with cystic fibrosis (CF). This study was the first to examine S. aureus isolates from CF patients in the Czech Republic. Among 100 S. aureus isolates from 92 of 107 observed patients, we found a high prevalence of resistance to macrolide-lincosamide-streptogramin B (MLS(B)) antibiotics (56%). More than half of the resistant strains (29 of 56) carried a mutation in the MLS(B) target site. The emergence of MLS(B) resistance and mutations conferring resistance to MLS(B) antibiotics was associated with azithromycin treatment (p=0.000000184 and p=0.000681, respectively). Methicillin resistance was only detected in 3% of isolates and the rate of resistance to other antibiotics did not exceed 12%. The prevalence of small-colony variant (SCV) strains was relatively low (9%) and eight of nine isolates with the SCV phenotype were thymidine dependent. The study population of S. aureus was heterogeneous in structure and both the most prevalent community-associated and hospital-acquired clonal lineages were represented. Of the virulence genes, enterotoxin genes seg (n=52), sei (n=49), and sec (n=16) were the most frequently detected among the isolates. The PVL genes (lukS-PV and lukF-PV) have not been revealed in any of the isolates.

  9. MIPAS temperature from the stratosphere to the lower thermosphere: Comparison of vM21 with ACE-FTS, MLS, OSIRIS, SABER, SOFIE and lidar measurements

    Directory of Open Access Journals (Sweden)

    M. García-Comas

    2014-11-01

    Full Text Available We present vM21 MIPAS temperatures from the lower stratosphere to the lower thermosphere, which cover all optimized resolution measurements performed by MIPAS in the middle-atmosphere, upper-atmosphere and noctilucent-cloud modes during its lifetime, i.e., from January 2005 to April 2012. The main upgrades with respect to the previous version of MIPAS temperatures (vM11 are the update of the spectroscopic database, the use of a different climatology of atomic oxygen and carbon dioxide, and the improvement in important technical aspects of the retrieval setup (temperature gradient along the line of sight and offset regularizations, apodization accuracy. Additionally, an updated version of ESA-calibrated L1b spectra (5.02/5.06 is used. The vM21 temperatures correct the main systematic errors of the previous version because they provide on average a 1–2 K warmer stratopause and middle mesosphere, and a 6–10 K colder mesopause (except in high-latitude summers and lower thermosphere. These lead to a remarkable improvement in MIPAS comparisons with ACE-FTS, MLS, OSIRIS, SABER, SOFIE and the two Rayleigh lidars at Mauna Loa and Table Mountain, which, with a few specific exceptions, typically exhibit differences smaller than 1 K below 50 km and than 2 K at 50–80 km in spring, autumn and winter at all latitudes, and summer at low to midlatitudes. Differences in the high-latitude summers are typically smaller than 1 K below 50 km, smaller than 2 K at 50–65 km and 5 K at 65–80 km. Differences between MIPAS and the other instruments in the mid-mesosphere are generally negative. MIPAS mesopause is within 4 K of the other instruments measurements, except in the high-latitude summers, when it is within 5–10 K, being warmer there than SABER, MLS and OSIRIS and colder than ACE-FTS and SOFIE. The agreement in the lower thermosphere is typically better than 5 K, except for high latitudes during spring and summer, when MIPAS usually exhibits larger

  10. Ticosonde CFH at Costa Rica: A Seasonal Climatology of Tropical UT-LS Water Vapor and Inter-Comparisons with MLS and CALIPSO

    Science.gov (United States)

    Selkirk, Henry B.; Voemel, Holger; Avery, Melody; Rosenlof, Karen; Davis, Sean; Hurst, Dale; Schoeberl, Mark; Diaz, Jorge Andres; Morris, Gary

    2014-01-01

    Balloon sonde measurements of tropical water vapor using the Cryogenic Frostpoint Hygrometer were initiated in Costa Rica in July 2005 and have continued to the present day. Over the nine years through July 2014, the Ticosonde program has launched 174 CFH payloads, representing the longest-running and most extensive single-site balloon dataset for tropical water vapor. In this presentation we present a seasonal climatology for water vapor and ozone at Costa Rica and examine the frequency of upper tropospheric supersaturation with comparisons to cloud fraction and cloud ice water content observations from the Cloud Aerosol Lidar with Orthogonal Polarization (CALIOP) on the CALIPSO mission. We then make a critical comparison of these data to water vapor measurements from the MLS instrument on board Aura in light of recently published work for other sites. Finally, we examine time series of 2-km altitude averages in the upper troposphere-lower stratosphere at Costa Rica in light of anomalies and trends seen in various large-scale indices of tropical water vapor.

  11. Project installation the large equipment in line system in Brazil. Gas export line valve P-40 FPSO-MLS. Field Marlim Sul, Campos Basin, Brazil; Operacao de instalacao do maior equipamento no sistema in line ja realizado no Brasil. Valvula do gasoduto P-40 X FPSO-MLS. Campo de Marlim Sul, Bacia de Campos, Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Marques, Marcos Antonio Rodrigues; Fernandes, Paulo Tavares [PETROBRAS, Campos dos Goytacases, RJ (Brazil). Exploracao e Producao

    2005-07-01

    This work will approach the current level of development of the installation of connected underwater equipment to flexible lines in the underwater engineering operations in Campos' Basin. The project will show studies, analysis and simulations (through software developed by PETROBRAS) about the installation of the largest equipment laid in the 'in-line' system (connected to flexible lines) in Brazil - and one of the largest of the world: the ESDV (Emergency Shut Down Valve) of the gas pipeline P-40 x FPSO-MLS, in the South Marlim field, in Campos' Basin. This ESDV, of about 18.000 kg, 4 m height and 6,5 m length, has the purpose of assuring the safety conditions on the facilities, interrupting the gas flow exported for P-40 in case of emergency situations. Its installation opened a new alternative in releasing underwater equipment, using the ships that install the flexible lines. This operation occurred in June, 2004, and required the use of a second vessel for support and monitoring of the ESDV laying. The ESDV was installed at 400 m from FPSO-MLS, in a water depth of 1.137 m. This method shall be used broadly by the company in the implantation of the new units of Campos' Basin, and the upcoming studies must consider the gradual increase of the water depth in the new projects. This work will focus the technological development in this area, and one of its purposes is to foresee the future difficulties that can appear in the implantation of the production systems in deep and ultra-deep waters. (author)

  12. TNU-9 Zeolite: Aluminum Distribution and Extra-Framework Sites of Divalent Cations

    Czech Academy of Sciences Publication Activity Database

    Karcz, R.; Dědeček, Jiří; Supronowicz, B.; Thomas, Haunani M.; Klein, Petr; Tabor, Edyta; Sazama, Petr; Pashková, Veronika; Sklenák, Štěpán

    2017-01-01

    Roč. 23, JUL 2017 (2017), s. 8857-8870 ISSN 1521-3765 R&D Projects: GA ČR(CZ) GA15-14007S; GA MŠk(CZ) LM2015073 Grant - others:Ga MŠk(CZ) LM2015070 Institutional support: RVO:61388955 Keywords : Aluminum * Cobalt * Density functional calculations * Structure elucidation * Zeolites Subject RIV: CF - Physical ; Theoretical Chemistry OBOR OECD: Physical chemistry

  13. TNU-9 Zeolite: Aluminum Distribution and Extra-Framework Sites of Divalent Cations

    Czech Academy of Sciences Publication Activity Database

    Karcz, R.; Dědeček, Jiří; Supronowicz, B.; Thomas, Haunani M.; Klein, Petr; Tabor, Edyta; Sazama, Petr; Pashková, Veronika; Sklenák, Štěpán

    Roč. 23, JUL 2017 (2017), s. 8857-8870 ISSN 1521-3765 R&D Projects: GA ČR(CZ) GA15-14007S; GA MŠk(CZ) LM2015073 Grant - others:Ga MŠk(CZ) LM2015070 Institutional support: RVO:61388955 Keywords : Aluminum * Cobalt * Density functional calculations * Structure elucidation * Zeolites Subject RIV: CF - Physical ; Theoretical Chemistry OBOR OECD: Physical chemistry

  14. Comparison of CMAM simulations of carbon monoxide (CO, nitrous oxide (N2O, and methane (CH4 with observations from Odin/SMR, ACE-FTS, and Aura/MLS

    Directory of Open Access Journals (Sweden)

    B. Barret

    2009-05-01

    Full Text Available Simulations of CO, N2O and CH4 from a coupled chemistry-climate model (CMAM are compared with satellite measurements from Odin Sub-Millimeter Radiometer (Odin/SMR, Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS, and Aura Microwave Limb Sounder (Aura/MLS. Pressure-latitude cross-sections and seasonal time series demonstrate that CMAM reproduces the observed global CO, N2O, and CH4 distributions quite well. Generally, excellent agreement with measurements is found between CO simulations and observations in the stratosphere and mesosphere. Differences between the simulations and the ACE-FTS observations are generally within 30%, and the differences between CMAM results and SMR and MLS observations are slightly larger. These differences are comparable with the difference between the instruments in the upper stratosphere and mesosphere. Comparisons of N2O show that CMAM results are usually within 15% of the measurements in the lower and middle stratosphere, and the observations are close to each other. However, the standard version of CMAM has a low N2O bias in the upper stratosphere. The CMAM CH4 distribution also reproduces the observations in the lower stratosphere, but has a similar but smaller negative bias in the upper stratosphere. The negative bias may be due to that the gravity drag is not fully resolved in the model. The simulated polar CO evolution in the Arctic and Antarctic agrees with the ACE and MLS observations. CO measurements from 2006 show evidence of enhanced descent of air from the mesosphere into the stratosphere in the Arctic after strong stratospheric sudden warmings (SSWs. CMAM also shows strong descent of air after SSWs. In the tropics, CMAM captures the annual oscillation in the lower stratosphere and the semiannual oscillations at the stratopause and mesopause seen in Aura/MLS CO and N2O observations and in Odin/SMR N2O observations. The Odin/SMR and Aura/MLS N2O observations also show a quasi

  15. Accuracy and precision of polar lower stratospheric temperatures from reanalyses evaluated from A-Train CALIOP and MLS, COSMIC GPS RO, and the equilibrium thermodynamics of supercooled ternary solutions and ice clouds

    Science.gov (United States)

    Lambert, Alyn; Santee, Michelle L.

    2018-02-01

    We investigate the accuracy and precision of polar lower stratospheric temperatures (100-10 hPa during 2008-2013) reported in several contemporary reanalysis datasets comprising two versions of the Modern-Era Retrospective analysis for Research and Applications (MERRA and MERRA-2), the Japanese 55-year Reanalysis (JRA-55), the European Centre for Medium-Range Weather Forecasts (ECMWF) interim reanalysis (ERA-I), and the National Oceanic and Atmospheric Administration (NOAA) National Centers for Environmental Prediction (NCEP) Climate Forecast System Reanalysis (NCEP-CFSR). We also include the Goddard Earth Observing System model version 5.9.1 near-real-time analysis (GEOS-5.9.1). Comparisons of these datasets are made with respect to retrieved temperatures from the Aura Microwave Limb Sounder (MLS), Constellation Observing System for Meteorology, Ionosphere and Climate (COSMIC) Global Positioning System (GPS) radio occultation (RO) temperatures, and independent absolute temperature references defined by the equilibrium thermodynamics of supercooled ternary solutions (STSs) and ice clouds. Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) observations of polar stratospheric clouds are used to determine the cloud particle types within the Aura MLS geometric field of view. The thermodynamic calculations for STS and the ice frost point use the colocated MLS gas-phase measurements of HNO3 and H2O. The estimated bias and precision for the STS temperature reference, over the 68 to 21 hPa pressure range, are 0.6-1.5 and 0.3-0.6 K, respectively; for the ice temperature reference, they are 0.4 and 0.3 K, respectively. These uncertainties are smaller than those estimated for the retrieved MLS temperatures and also comparable to GPS RO uncertainties (bias 0.7 K) in the same pressure range. We examine a case study of the time-varying temperature structure associated with layered ice clouds formed by orographic gravity waves forced by flow over the Palmer Peninsula and

  16. The climatology, propagation and excitation of ultra-fast Kelvin waves as observed by meteor radar, Aura MLS, TRMM and in the Kyushu-GCM

    Directory of Open Access Journals (Sweden)

    R. N. Davis

    2012-02-01

    Full Text Available Wind measurements from a meteor radar on Ascension Island (8° S, 14° W and simultaneous temperature measurements from the Aura MLS instrument are used to characterise ultra-fast Kelvin waves (UFKW of zonal wavenumber 1 (E1 in the mesosphere and lower thermosphere (MLT in the years 2005–2010. These observations are compared with some predictions of the Kyushu-general circulation model. Good agreement is found between observations of the UFKW in the winds and temperatures, and also with the properties of the waves in the Kyushu-GCM. UFKW are found at periods between 2.5–4.5 days with amplitudes of up to 40 m s−1 in the zonal winds and 6 K in the temperatures. The average vertical wavelength is found to be 44 km. Amplitudes vary with latitude in a Gaussian manner with the maxima centred over the equator. Dissipation of the waves results in monthly-mean eastward accelerations of 0.2–0.9 m s−1 day−1 at heights around 95 km, with 5-day mean peak values of 4 m s−1 day−1. Largest wave amplitudes and variances are observed over Indonesia and central Africa and may be a result of very strong moist convective heating over those regions. Rainfall data from TRMM are used as a proxy for latent-heat release in an investigation of the excitation of these waves. No strong correlation is found between the occurrence of large-amplitude mesospheric UFKW events and either the magnitude of the equatorial rainfall or the amplitudes of E1 signatures in the rainfall time series, indicating that either other sources or the propagation environment are more important in determining the amplitude of UFKW in the MLT. A strong semiannual variation in wave amplitudes is observed. Intraseasonal oscillations (ISOs with periods 25–60 days are evident in the zonal background winds, zonal-mean temperature, UFKW amplitudes, UFKW accelerations and the rainfall rate. This suggests that UFKW play a role in

  17. Vertical and interhemispheric links in the stratosphere-mesosphere as revealed by the day-to-day variability of Aura-MLS temperature data

    Directory of Open Access Journals (Sweden)

    X. Xu

    2009-09-01

    Full Text Available The coupling processes in the middle atmosphere have been a subject of intense research activity because of their effects on atmospheric circulation, structure, variability, and the distribution of chemical constituents. In this study, the day-to-day variability of Aura-MLS (Microwave Limb Sounder temperature data are used to reveal the vertical and interhemispheric coupling processes in the stratosphere-mesosphere during four Northern Hemisphere winters (2004/2005–2007/2008. The UKMO (United Kingdom Meteorological Office assimilated data and mesospheric winds from MF (medium frequency radars are also applied to help highlight the coupling processes. In this study, a clear vertical link can be seen between the stratosphere and mesosphere during winter months. The coolings and reversals of northward meridional winds in the polar winter mesosphere are often observed in relation to warming events (Sudden Stratospheric Warming, SSW for short and the associated changes in zonal winds in the polar winter stratosphere. An upper-mesospheric cooling usually precedes the beginning of the warming in the stratosphere by 1–2 days. Inter-hemispheric coupling has been identified initially by a correlation analysis using the year-to-year monthly zonal mean temperature. Then the correlation analyses are performed based upon the daily zonal mean temperature. From the original time sequences, significant positive (negative correlations are generally found between zonal mean temperatures at the Antarctic summer mesopause and in the Arctic winter stratosphere (mesosphere during northern mid-winters, although these correlations are dominated by the low frequency variability (i.e. the seasonal trend. Using the short-term oscillations (less than 15 days, the statistical result, by looking for the largest magnitude of correlation within a range of time-lags (0 to 10 days; positive lags mean that the Antarctic summer mesopause is lagging, indicates that the temporal

  18. Vertical and interhemispheric links in the stratosphere-mesosphere as revealed by the day-to-day variability of Aura-MLS temperature data

    Directory of Open Access Journals (Sweden)

    X. Xu

    2009-09-01

    Full Text Available The coupling processes in the middle atmosphere have been a subject of intense research activity because of their effects on atmospheric circulation, structure, variability, and the distribution of chemical constituents. In this study, the day-to-day variability of Aura-MLS (Microwave Limb Sounder temperature data are used to reveal the vertical and interhemispheric coupling processes in the stratosphere-mesosphere during four Northern Hemisphere winters (2004/2005–2007/2008. The UKMO (United Kingdom Meteorological Office assimilated data and mesospheric winds from MF (medium frequency radars are also applied to help highlight the coupling processes.

    In this study, a clear vertical link can be seen between the stratosphere and mesosphere during winter months. The coolings and reversals of northward meridional winds in the polar winter mesosphere are often observed in relation to warming events (Sudden Stratospheric Warming, SSW for short and the associated changes in zonal winds in the polar winter stratosphere. An upper-mesospheric cooling usually precedes the beginning of the warming in the stratosphere by 1–2 days.

    Inter-hemispheric coupling has been identified initially by a correlation analysis using the year-to-year monthly zonal mean temperature. Then the correlation analyses are performed based upon the daily zonal mean temperature. From the original time sequences, significant positive (negative correlations are generally found between zonal mean temperatures at the Antarctic summer mesopause and in the Arctic winter stratosphere (mesosphere during northern mid-winters, although these correlations are dominated by the low frequency variability (i.e. the seasonal trend. Using the short-term oscillations (less than 15 days, the statistical result, by looking for the largest magnitude of correlation within a range of time-lags (0 to 10 days; positive lags mean that the Antarctic summer mesopause is lagging, indicates

  19. An Application of Cognitive Diagnostic Assessment on TIMMS-2007 8th Grade Mathematics Items

    Science.gov (United States)

    Toker, Turker; Green, Kathy

    2012-01-01

    The least squares distance method (LSDM) was used in a cognitive diagnostic analysis of TIMSS (Trends in International Mathematics and Science Study) items administered to 4,498 8th-grade students from seven geographical regions of Turkey, extending analysis of attributes from content to process and skill attributes. Logit item positions were…

  20. Terminal area automatic navigation, guidance and control research using the Microwave Landing System (MLS). Part 5: Design and development of a Digital Integrated Automatic Landing System (DIALS) for steep final approach using modern control techniques

    Science.gov (United States)

    Halyo, N.

    1983-01-01

    The design and development of a 3-D Digital Integrated Automatic Landing System (DIALS) for the Terminal Configured Vehicle (TCV) Research Aircraft, a B-737-100 is described. The system was designed using sampled data Linear Quadratic Gaussian (LOG) methods, resulting in a direct digital design with a modern control structure which consists of a Kalman filter followed by a control gain matrix, all operating at 10 Hz. DIALS uses Microwave Landing System (MLS) position, body-mounted accelerometers, as well as on-board sensors usually available on commercial aircraft, but does not use inertial platforms. The phases of the final approach considered are the localizer and glideslope capture which may be performed simultaneously, localizer and steep glideslope track or hold, crab/decrab and flare to touchdown. DIALS captures, tracks and flares from steep glideslopes ranging from 2.5 deg to 5.5 deg, selected prior to glideslope capture. Digital Integrated Automatic Landing System is the first modern control design automatic landing system successfully flight tested. The results of an initial nonlinear simulation are presented here.

  1. Dehydration, denitrification and ozone loss during the Arctic winter 2015/2016: Simulations with the Chemistry-Climate Model EMAC and comparison to Aura/MLS and GLORIA observations

    Science.gov (United States)

    Khosrawi, Farahnaz; Kirner, Oliver; Sinnhuber, Bjoern-Martin; Johansson, Sören; Höpfner, Michael; Santee, Michelle L.; Manney, Gloria; Froidevaux, Lucien; Ungermann, Jörn; Preusse, Peter; Friedl-Vallon, Felix; Ruhnke, Roland; Woiwode, Wolfgang; Oelhaf, Hermann; Braesicke, Peter

    2017-04-01

    The Arctic winter 2015/2016 has been one of the coldest stratospheric winters in recent years. A stable vortex formed already in early December and the early winter has been exceptionally cold. Cold pool temperatures dropped below the Nitric Acid Trihydrate (NAT) existence temperature, thus allowing Polar Stratospheric Clouds (PSCs) to form. The low temperatures in the polar stratosphere persisted until early March allowing chlorine activation and catalytic ozone destruction. Satellite observations indicate that sedimentation of PSC particles have led to denitrification as well as dehydration of stratospheric layers. Nudged model simulations of the Arctic winter 2015/2016 were performed with the atmospheric chemistry-climate model ECHAM5/MESSy Atmospheric Chemistry (EMAC) for the POLSTRACC (Polar Stratosphere in a Changing Climate) campaign. POLSTRACC was a HALO mission (High Altitude and LOng Range Research Aircraft) aiming on the investigation of the structure, composition and evolution of the Arctic Upper Troposphere Lower Stratosphere (UTLS). The chemical and physical processes involved in Arctic stratospheric ozone depletion, transport and mixing processes in the UTLS at high latitudes, polar stratospheric clouds as well as cirrus clouds were investigated. In this presentation, an overview of the chemistry and dynamics of the Arctic winter 2015/2016 as simulated with EMAC will be given. Chemical-dynamical processes such as denitrification, dehydration and ozone loss will be investigated. Comparisons to satellite observations by the Aura Microwave Limb Sounder (Aura/MLS) as well as to airborne measurements with the Gimballed Limb Observer for Radiance Imaging of the Atmosphere (GLORIA) performed onboard of HALO during the POLSTRACC campaign show that the EMAC simulations are in good agreement with observations (differences generally within ±20%). However, larger differences between model and simulations are found e.g. in the areas of denitrification. Both

  2. Heategu läbi minu silmade / Mikko Leo Selg ; toimetaja Juhani Püttsepp ; kommenteerija Uudo Timm

    Index Scriptorium Estoniae

    Selg, Mikko Leo

    2011-01-01

    Lions klubi ja haridusministeeriumi korraldatud kirjandusvõistluse "Heategu läbi minu silmade" keskmises vanuserühmas (11-14 aastat) kolmanda koha saavutanud Tartu Forseliuse gümnaasiumi õpilase Mikko Leo Selja võistlustöö, mis kirjeldab ohustatud lendorava liigi uurimiseks ja kaitsmiseks tehtud korjandust

  3. Applying Bourdieu’s Field Theory to MLS Curricula Development

    DEFF Research Database (Denmark)

    Wien, Charlotte; Dorch, Bertil F.

    Our research question is: How can adequate education in Library and Information Science be provided for subject specialists in research libraries under constant change? Research libraries may be one of the places where imprints of the transition from industrial society to knowledge society are most...... evident. In order to keep up, the library profession has had to incorporate numerous new disciplines and has become a highly specialized area with its own Ph.D. program. But while developing the curricula within the discipline of library and information science (LIS), the training programs for the subject...... specialists of the research libraries tend to have been neglected in Denmark. Until the turn of the millennium, a subject specialist in a Danish research library would typically start their career by applying for a vacancy in connection with a subject specialist’s MA or Ph.D. specialization...

  4. Breaking teleprinter ciphers at Bletchley Park an edition of I.J. Good, D. Michie and G. Timms : general report on tunny with emphasis on statistical methods (1945)

    CERN Document Server

    Diffie, W; Field, J

    2015-01-01

    This detailed technical account of breaking Tunny is an edition of a report written in 1945, with extensive modern commentary Breaking Teleprinter Ciphers at Bletchley Park gives the full text of the General Report on Tunny (GRT) of 1945, making clear how the ideas, notation and the specially designed machines that were used differ from what was generally accepted in 1945, and, where a modern reader might be misled, from what is understood now. The editors of this book clarify the sometimes slightly strange language of the GRT and explain the text within a variety of contexts in several separate historical story lines, some only implicit in the GRT itself. The first story, told by the authors of the GRT, describes how, using specially designed machines, including from 1944 the "Colossus", the British broke the enciphered teleprinter messages sent by the highest command levels of the Germany Army. The cipher machines the Germans used were the Loren SZ 40 series, called "Tunny" by the British. The second stor...

  5. MLS Performance Assessment, Task IV. Volume I. Evaluation Procedures and Equipment Design.

    Science.gov (United States)

    1980-12-01

    i.n 17.ic 0C-a - -.... iV -- 0*7aa~ n ~ .. 0 7 Z4 at-a. ~ ~ ~ ~ ~ ~ 2 7 . 0 - O..n - C. - 7c -c a.. -... acaI ~~ ao o- - - -.U r> - - - 7aa1 ; Ia a ~ aCO...system is a manual-tracking system requiring good visibility, the benefits obtained from continuous track-while-ranging operation and the provision of

  6. Simple Approaches to Improve the Automatic Inventory of ZEBRA Crossing from Mls Data

    Science.gov (United States)

    Arias, P.; Riveiro, B.; Soilán, M.; Díaz-Vilariño, L.; Martínez-Sánchez, J.

    2015-08-01

    The city management is increasingly supported by information technologies, leading to paradigms such as smart cities, where decision-makers, companies and citizens are continuously interconnected. 3D modelling turns of great relevance when the city has to be managed making use of geospatial databases or Geographic Information Systems. On the other hand, laser scanning technology has experienced a significant growth in the last years, and particularly, terrestrial mobile laser scanning platforms are being more and more used with inventory purposes in both cities and road environments. Consequently, large datasets are available to produce the geometric basis for the city model; however, this data is not directly exploitable by management systems constraining the implementation of the technology for such applications. This paper presents a new algorithm for the automatic detection of zebra crossing. The algorithm is divided in three main steps: road segmentation (based on a PCA analysis of the points contained in each cycle of collected by a mobile laser system), rasterization (conversion of the point cloud to a raster image coloured as a function of intensity data), and zebra crossing detection (using the Hough Transform and logical constrains for line classification). After evaluating different datasets collected in three cities located in Northwest Spain (comprising 25 strips with 30 visible zebra crossings) a completeness of 83% was achieved.

  7. VoIP Quality Measurements in a Multilevel Secure (MLS) Environment

    National Research Council Canada - National Science Library

    Adams, Jr, Coy M

    2008-01-01

    Voice over Internet Protocol (VoIP) is growing in popularity in the civilian and military communities due to its low cost and the management advantages it offers over traditional Public Switched Telephone Networks (PSTN) phone systems...

  8. Dva nové dokumenty o návštěvě prezidenta Edvarda Beneše ve Spojených státech amerických a Kanadě v květnu a červnu 1943

    Czech Academy of Sciences Publication Activity Database

    Dejmek, Jindřich

    2008-01-01

    Roč. 16, - (2008), s. 291-320 ISSN 1210-6860 Institutional research plan: CEZ:AV0Z80150510 Keywords : History of Czechoslovak Foreign Policy * History of Diplomacy * History of International Relations Subject RIV: AB - History

  9. An Analysis of the Requirements for and the Costs and Benefits of the National Microwave Landing System (MLS). Volume I,

    Science.gov (United States)

    1980-06-01

    Office of Systems Engineering Management Washington, D.C. 20591 13. Tyo ol Report and P.,.od Co ered 12. Sponsoring Agency Main* and Address...presence of hazardous wake vortices created by large heavy aircraft during low speeds on final approach or departure. d. Area Navigation (RNAV) - this is...the effected terminal airspace to disperse (i.e., navigate) along standard routes using specified speed profiles to holding fixes. However, over the

  10. Wow! 3D Content Awakens the Classroom

    Science.gov (United States)

    Gordon, Dan

    2010-01-01

    From her first encounter with stereoscopic 3D technology designed for classroom instruction, Megan Timme, principal at Hamilton Park Pacesetter Magnet School in Dallas, sensed it could be transformative. Last spring, when she began pilot-testing 3D content in her third-, fourth- and fifth-grade classrooms, Timme wasn't disappointed. Students…

  11. Perforant path lesioning induces sprouting of CA3-associated fibre systems in mouse hippocampal formation

    DEFF Research Database (Denmark)

    Drøjdahl, Nina; Hegelund, Iørn V; Poulsen, Frantz R

    2002-01-01

    mice. We found that lesioning led to translaminar sprouting of Timm stained regio inferior hippocampus (CA3)-associated fibre systems into the denervated termination zones of the CA3 and dentate gyrus, from the adjacent non-denervated stratum radiatum of CA3. Differences were seen in the Timm staining...

  12. What the multiline signal (MLS) simulation data with average of weighted computations reveal about the Mn hyperfine interactions and oxidation states of the manganese cluster in OEC?

    Science.gov (United States)

    Baituti, Bernard

    2017-11-01

    Understanding the structure of oxygen evolving complex (OEC) fully still remains a challenge. Lately computational chemistry with the data from more detailed X-ray diffraction (XRD) OEC structure, has been used extensively in exploring the mechanisms of water oxidation in the OEC (Gatt et al., J. Photochem. Photobiol. B 104(1-2), 80-93 2011). Knowledge of the oxidation states is very crucial for understanding the core principles of catalysis by photosystem II (PSII) and catalytic mechanism of OEC. The present study involves simulation studies of the X-band continuous wave electron-magnetic resonance (CW-EPR) generated S 2 state signals, to investigate whether the data is in agreement with the four manganese ions in the OEC, being organised as a `3 + 1' (trimer plus one) model (Gatt et al., Angew. Chem. Int. Ed. 51, 12025-12028 2012; Petrie et al., Chem. A Eur. J. 21, 6780-6792 2015; Terrett et al., Chem. Commun. (Camb.) 50, 8-11 2014) or `dimer of dimers' model (Terrett et al. 2016). The question that still remains is how much does each Mn ion contribute to the " g2multiline" signal through its hyperfine interactions in OEC also to differentiate between the `high oxidation state (HOS)' and `low oxidation state (LOS)' paradigms? This is revealed in part by the structure of multiline (ML) signal studied in this project. Two possibilities have been proposed for the redox levels of the Mn ions within the catalytic cluster, the so called `HOS' and `LOS' paradigms (Gatt et al., J. Photochem. Photobiol. B 104(1-2), 80-93 2011). The method of data analysis involves numerical simulations of the experimental spectra on relevant models of the OEC cluster. The simulations of the X-band CW-EPR multiline spectra, revealed three manganese ions having hyperfine couplings with large anisotropy. These are most likely Mn III centres and these clearly support the `LOS' OEC paradigm model, with a mean oxidation of 3.25 in the S2 state. This is consistent with the earlier data by Jin et al. (Phys. Chem. Chem. Phys. (PCCP) 16(17), 7799-812 2014), but the present results clearly indicate that heterogeneity in hyperfine couplings exist in samples as typically prepared.

  13. Features of the seasonal variation of the semidiurnal, terdiurnal and 6-h components of ozone heating evaluated from Aura/MLS observations

    Directory of Open Access Journals (Sweden)

    J. Xu

    2012-02-01

    Full Text Available This paper presents the thermal forcing of the semidiurnal, terdiurnal, and 6-h components of the migrating tide induced by ozone heating in stratosphere and lower mesosphere. The heating as a function of local time is determined from the global ozone observed by the Microwave Limb Sounder on the Aura satellite. The harmonic components of the heating rates of the semidiurnal, terdiurnal and the 6-h periodicities are calculated using the Strobel/Zhu parameterized model and then decomposed into Hough modes. Seasonal variations of each harmonic component and its Hough modes are presented. For all three tidal components, the majority of the annual mean O3 heating projects onto symmetric modes. The semiannual variation is a prominent signal in almost all of the symmetric Hough modes near the stratopause. The strongest annual variation takes place in the asymmetric modes. The results also show that, during the solstice season, the maximum forcing of the diurnal and terdiurnal component occurs in the summer hemisphere while the maximum forcing of the semidiurnal and 6-h components occurs in the winter hemisphere. The global mean ozone density and the tidal components of the ozone heating rate are different between December–January and June–July. The asymmetry in the heating is primarily due to the 6.6% annual variation in the solar energy input into the Earth's atmosphere due to the annual variation of the Sun-Earth distance.

  14. Comparison of GPS/SAC-C and MIPAS/ENVISAT temperature profiles and its implementation for EOS AURA-MLS observations

    Science.gov (United States)

    Jiang, Jonathan H.; Wang, Ding-Yi; Romans, Larry J.; Ao, Chi O.; Schwartz, Michael J.; Stiller, Gabriele P.; von Clarmann, Thomas; Lopez-Puertas, Manuel; Funke, Bernd; Gil-Lopez, Sergio; hide

    2003-01-01

    A new generation GPS flight receiver was launched on the Argentinian satellite SAC-C in 2001. It has demonstrated the potential applicability for the continuous monitoring of the earth's atmosphere with radio occultation technology, and providing high vertical resolution profiles of temperature and water vapour data complementary to other sounding techniques.

  15. Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA

    DEFF Research Database (Denmark)

    Douthwaite, S; Hansen, L H; Mauvais, P

    2000-01-01

    of the cladinose, and substitution of a 3-keto group (forming the ketolide RU 56006), results in loss of the A752 interaction and an approximately 100-fold drop in drug binding affinity. Within domain V, the key determinant of drug binding is nucleotide A2058 and substitution of G at this position is the major...

  16. Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA

    DEFF Research Database (Denmark)

    Douthwaite, S; Hansen, L H; Mauvais, P

    2000-01-01

    The macrolide antibiotic erythromycin and its 6-O-methyl derivative (clarithromycin) bind to bacterial ribosomes primarily through interactions with nucleotides in domains II and V of 23S rRNA. The domain II interaction occurs between nucleotide A752 and the macrolide 3-cladinose moiety. Removal...... cause of drug resistance in some clinical pathogens. The 2058G mutation disrupts the drug-domain V contact and leads to a further > 25 000-fold decrease in the binding of RU 56006. Drug binding to resistant ribosomes can be improved over 3000-fold by forming an alternative and more effective contact...... to A752 via alkyl-aryl groups linked to a carbamate at the drug 11/12 position (in the ketolide antibiotics HMR 3647 and HMR 3004). The data indicate that simultaneous drug interactions with domains II and V strengthen binding and that the domain II contact is of particular importance to achieve...

  17. Catalytic transformation of methyl benzenes over zeolite catalysts

    Czech Academy of Sciences Publication Activity Database

    Al-Khattaf, S.; Akhtar, M. N.; Odedairo, T.; Aitani, A.; Tukur, N. M.; Kubů, Martin; Musilová, Zuzana; Čejka, Jiří

    2011-01-01

    Roč. 394, 1-2 (2011), s. 176-190 ISSN 0926-860X R&D Projects: GA ČR GD203/08/H032 Institutional research plan: CEZ:AV0Z40400503 Keywords : ZSM-5 * TNU-9 * mordenite Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 3.903, year: 2011

  18. Filmitegijate võidujooks murenevas maailmas / Viio Aitsam

    Index Scriptorium Estoniae

    Aitsam, Viio, 1955-

    2011-01-01

    14.-18. septembrini toimub Lihulas 9. Matsalu loodusfilmide festival. Võistlusprogrammi kuuluvast Randall Woodi filmist "Vihmaussikütid" (Austraalia, 2011). Võrtsjärve limnoloogiajaama teadlane Tarmo Timm osaleb filmis oma vihmaussiga, kes on laboratooriumitingimustes elanud juba 45 aastat

  19. Tõuni imekitarr kõlab nagu mesi . Pedaal-steel teeb popmuusikas taassündi / Rando Tooming

    Index Scriptorium Estoniae

    Tooming, Rando

    2009-01-01

    Muusik Tõnu Timm jutustab loo, kuidas hankis Ameerikast haruldase pedaal-steel- kitarri. Eesti kasutusel olevatest vanematest pedaal-steel-kitarridest. Ansamblid, kus kasutatakse kõneall olevat kitarri

  20. Morning Report Presentation with Literature Search Associated with Decreased Length of Hospital Stay. A Review of: Banks, Daniel E., Runhus Shi, Donna F. Timm, Kerri Ann Christopher, David Charles Duggar, Marianne Comegys, and Jerry McLarty. “Decreased Hospital Length of Stay Associated with Presentation of Cases at Morning Report with Librarian Support.” Journal of the Medical Library Association 95.4 (Oct. 2007: 381-87.

    Directory of Open Access Journals (Sweden)

    Jennie Kelson

    2008-09-01

    Full Text Available Objective – To determine whether hospital charges, length of stay or 30-day readmission rates were affected by case discussion at residents’ morning report (MR, accompanied by librarian-provided literature search results, within 24 hours of admission. Design – Case-control study and survey.Setting – Louisiana State University School of Medicine.Subjects – MR cases presented during the study period August 2004 to March 2005 matched with one to three cases (controls of patients who were hospitalised in the period January 2000 to July 2005. House officers who presented the MR cases during the study period were the subjects for the survey.Methods – MR cases were presented between 8:00am and 9:00am, five days a week, and only one case was presented at each MR. During the study period, August 2004 to March 2005, the presenting house officer selected independently a case for presentation at MR from patients admitted during the previous 24 hours. The selection was made without guidance as to which cases or illnesses to choose and without the knowledge or involvement of the attending physician or investigators. The term “house officer” is not defined in the article so it is not clear whether this refers to medical residents only, or if it includes interns. The faculty librarian, with clinical input from the chief resident or the chair of the Department of Medicine, conducted a search of the medical literature immediately following the MR to identify articles or citations that would answer two questions posed at the end of the presentation. The chair of the department or chief resident selected the articles that provided the most clinically sound answers to the questions. By 10:00 am, copies of the selected articles were hand-delivered to the presenting house officer and shared with members of the ward team.For the case-control component, the MR cases presented during the study period were matched against a comparison group of patients who were hospitalised in the period January 2000 to July 2005. Matching of controls to the MR cases was made on the basis of the primary International Classification of Diseases (ICD-9 diagnostic code, patient age and concomitant secondary diagnosis. MR cases with nomatching control case were excluded from analysis of length of stay, costs or readmission rates. A maximum of three control cases were randomly selected where a MR case matched with more than three control cases. Data regarding demographic information of the patient (age, sex, race, insurance coverage, marital status and number of diseases diagnosed, the length of stay, total hospitalisation charges and readmission rates within 30 days of initial discharge were extracted from the medical records of matched MR and control cases. Statistical tests (Student T or chi-squared tests were used to compare differences between the demographic details of patients in the MR group and the control cases. Wilcoxon signed rank test and Sign test were used to analyse nonparametric data such as length of stay and hospital charges. Median values, rather than the mean, wereused for the outcome measures to reduce the influence of any extreme or outlier values. The researchers considered a p value less than p = 0.05 to be statistically significant. For the survey component of the study, each presenting house officer was asked to complete a questionnaire for each MR case they presented during the study period, which asked them to comment on the quality of the articles located in response to the questions posed at the MR and to saywhether the information would influence their treatment of the patient. A copy of the questionnaire is accessible online via a linkwithin the article; however it is not stated who analyzed the results or how this was done.Main Results – Of the 105 cased presented at MR during the study period, 55 cases could be matched with at least one control up to a maximum of three cases, resulting in a total of 136 control cases.Statistical analysis of the MR cases and the control cases showed no significant difference in the demographic details between the groups.MR cases had a median length of stay of three days compared to five days for control cases. This difference was statistically significant (p = 0.0238. A logarithmic plot comparing length of stay between MR cases and controls showed a positive association that was statistically significant (p = 0.012 between presentation at MR and a reduced median length of stay. Median hospitalisation charges were $7,045 for the MR cases and $10,663 for the controlcases; however, the difference was not statistically significant (p = 0.24. A logarithmic plot for total charges showed that, in most cases, charges for MR cases were lower than controls; however, thedifferences did not reach statistical significance (p = 0.18. Readmission rates within thirty days of initial discharge were 16.4% for MR cases and 16.8% for controls. There was no statistically significant difference in readmission rates between the groups (p >0.88. Analysis of the survey responses found that the house officers commented on the quality of the articles for 60 of the 105 MR cases presented. In 43 cases, the house officer commented that the articles had a positive influence on patient management. Comments for a further ten cases indicated that, although they did not alter the management of MR patient cases, the house officers believed that the articles provided good background information which may be helpful in the future. Seven other comments indicated that the articles had not influenced their patient management in anyrespect.Conclusion – Presentation of cases at MR accompanied by dissemination of literature search results resulted in a statistically significant shortened median length of stay and lower hospital charges compared to matched control cases. Readmission rates within 30 days of first diagnosis showed no differences between MR cases and control cases. Supplementary survey results found that the 41% of the presenting house officers believed that the literature search information provided following the MR presentation positively influenced patient management.

  1. Seizure complicating interscalene brachail plexus block | Idehen ...

    African Journals Online (AJOL)

    We describe a case of seizure occurring immediately after completion of interscalene brachial plexus block, using 20mls mixture of 10mls of 0.5% bupivacaine and 10mls of 2% lidocaine with adrenaline for post operative analgesia. Seizure occurred despite negative test aspiration and non response to the use of 0.5mls of ...

  2. Annual Knowledge-Based Software Assistant Conference (2nd) Held on 18-20 August 1987 in Utica, New York.

    Science.gov (United States)

    1988-01-01

    tnu:~tonbrowser sim~ilar in (lesigii to \\(o iwi i’l %%’!! 1- rinit i nivei, user of the B:ouhaws to Find :1 dfescri-JptioIll i c: t e in rl ’ eaIilv...kbsa PEI- FOOD : (6) 8 3i Wro((SATIC TYPE POSITIOn, STATIC TYPE REGION, 9 &0W tc-d&%*.qist 3kbs. PET- FOOD :)) eIUnda1 STOP-SP-STARTt Figure 1-1: Structure

  3. Achieving Lower Nitrogen Balance and Higher Nitrogen Recovery Efficiency Reduces Nitrous Oxide Emissions in North America's Maize Cropping Systems.

    Science.gov (United States)

    Omonode, Rex A; Halvorson, Ardell D; Gagnon, Bernard; Vyn, Tony J

    2017-01-01

    Few studies have assessed the common, yet unproven, hypothesis that an increase of plant nitrogen (N) uptake and/or recovery efficiency (NRE) will reduce nitrous oxide (N 2 O) emission during crop production. Understanding the relationships between N 2 O emissions and crop N uptake and use efficiency parameters can help inform crop N management recommendations for both efficiency and environmental goals. Analyses were conducted to determine which of several commonly used crop N uptake-derived parameters related most strongly to growing season N 2 O emissions under varying N management practices in North American maize systems. Nitrogen uptake-derived variables included total aboveground N uptake (TNU), grain N uptake (GNU), N recovery efficiency (NRE), net N balance (NNB) in relation to GNU [NNB (GNU) ] and TNU [NNB (TNU) ], and surplus N (SN). The relationship between N 2 O and N application rate was sigmoidal with relatively small emissions for N rates emission increased by about 5, 7, and 8 g N, respectively, per kg increase of NNB (GNU) , NNB (TNU) , and SN. Neither N source nor placement influenced the relationship between N 2 O and NRE. Overall, our analysis indicated that a careful selection of appropriate N rate applied at the right time can both increase NRE and reduce N 2 O. However, N 2 O reduction benefits of optimum N rate-by-timing practices were achieved most consistently with management systems that reduced NNB through an increase of grain N removal or total plant N uptake relative to the total fertilizer N applied to maize. Future research assessing crop or N management effects on N 2 O should include N uptake parameter measurements to better understand N 2 O emission relationships to plant NRE and N uptake.

  4. Catalytic transformation of methyl benzenes over zeolite catalysts

    KAUST Repository

    Al-Khattaf, S.

    2011-02-01

    Catalytic transformation of three methyl benzenes (toluene, m-xylene, and 1,2,4-trimethyl benzene) has been investigated over ZSM-5, TNU-9, mordenite and SSZ-33 catalysts in a novel riser simulator at different operating conditions. Catalytic experiments were carried out in the temperature range of 300-400 °C to understand the transformation of these alkyl benzenes over large pore (mordenite and SSZ-33) in contrast to medium-pore (ZSM-5 and TNU-9) zeolite-based catalysts. The effect of reaction conditions on the isomerization to disproportionation product ratio, distribution of trimethylbenzene (TMB) isomers, and p-xylene/o-xylene ratios are reported. The sequence of reactivity of the three alkyl benzenes depends upon the pore structure of zeolites. The zeolite structure controls primarily the diffusion of reactants and products while the acidity of these zeolites is of a secondary importance. In the case of medium pore zeolites, the order of conversion was m-xylene > 1,2,4-TMB > toluene. Over large pore zeolites the order of reactivity was 1,2,4-TMB > m-xylene > toluene for SSZ-33 catalyst, and m-xylene ∼ 1,2,4-TMB > toluene over mordenite. Significant effect of pore size between ZSM-5 and TNU-9 was observed; although TNU-9 is also 3D 10-ring channel system, its slightly larger pores compared with ZSM-5 provide sufficient reaction space to behave like large-pore zeolites in transformation of aromatic hydrocarbons. We have also carried out kinetic studies for these reactions and activation energies for all three reactants over all zeolite catalysts under study have been calculated. © 2011 Elsevier B.V.

  5. Ethylene formation by dehydration of ethanol over medium pore zeolites

    Science.gov (United States)

    Gołąbek, Kinga; Tarach, Karolina A.; Filek, Urszula; Góra-Marek, Kinga

    2018-03-01

    In this work, the role of pore arrangement of 10-ring zeolites ZSM-5, TNU-9 and IM-5 on their catalytic properties in ethanol transformation were investigated. Among all the studied catalysts, the zeolite IM-5, characterized by limited 3-dimensionality, presented the highest conversion of ethanol and the highest yields of diethyl ether (DEE) and ethylene. The least active and selective to ethylene and C3 + products was zeolite TNU-9 with the largest cavities formed on the intersection of 10-ring channels. The catalysts varied, however, in lifetime, and their deactivation followed the order: IM-5 > TNU-9 > ZSM-5. The processes taking place in the microporous zeolite environment were tracked by IR spectroscopy and analysed by the 2D correlation analysis (2D COS) allowing for an insight into the nature of chemisorbed adducts and transition products of the reaction. The cage dimension was found as a decisive factor influencing the tendency for coke deposition, herein identified as polymethylated benzenes, mainly 1,2,4-trimethyl-benzene.

  6. Alterations in expression levels of deafness dystonia protein 1 affect mitochondrial morphology

    DEFF Research Database (Denmark)

    Engl, Gertraud; Florian, Stefan; Tranebjærg, Lisbeth

    2012-01-01

    Deafness-Dystonia-Optic Neuropathy (DDON) Syndrome is a rare X-linked progressive neurodegenerative disorder resulting from mutations in the TIMM8A gene encoding for the deafness dystonia protein 1 (DDP1). Despite important progress in identifying and characterizing novel mutations in this gene...

  7. Science Education Reform in Qatar: Progress and Challenges

    Science.gov (United States)

    Said, Ziad

    2016-01-01

    Science education reform in Qatar has had limited success. In the Trends in International Mathematics and Science Study (TIMMS), Qatari 4th and 8th grade students have shown progress in science achievement, but they remain significantly below the international average. Also, in the Program for International Student Assessment (PISA), Qatari…

  8. Optimal control of the initiation of a pericyclic reaction in the ...

    Indian Academy of Sciences (India)

    Optimal control of the initiation of a pericyclic reaction in the electronic ground state. #. TIMM BREDTMANN. ∗ and JÖRN MANZ. ∗. Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany e-mail: bredt@chemie.fu-berlin.de; jmanz@chemie.fu-berlin.de. Abstract. Pericyclic reactions in ...

  9. Heavy metals in the spinal cord of normal rats and of animals treated with chelating agents

    DEFF Research Database (Denmark)

    Schrøder, H D; Fjerdingstad, E; Danscher, G

    1978-01-01

    of various levels along the cranio-caudal axis of the rat spinal cord revealed differences in the heavy metal content. The Timm sulfide silver staining method has demonstrated that metals in the spinal cord have a distinct regional distribution. To obtain a differentiation between the stainable metals...

  10. Commentary on "How Task Features Impact Evidence from Assessments Embedded in Simulations and Games" by Almond et al.

    Science.gov (United States)

    Timms, Mike

    2014-01-01

    In his commentary on "How Task Features Impact Evidence from Assessments Embedded in Simulations and Games" by Almond et al., Mike Timms writes that his own research has involved the use of embedded assessments using simulations in interactive learning environments, and the Evidence Centered Design (ECD) approach has provided a solid…

  11. 77 FR 60749 - Endangered and Threatened Wildlife and Plants; Proposed Endangered Species Status for the Florida...

    Science.gov (United States)

    2012-10-04

    .... 857). Like other molossids, color is highly variable; color varies from black to brown to brownish... appear varied, with the species occurring in forested, suburban, and urban areas (Timm and Arroyo... cavities, including woodpecker holes and cavities in royal palms, ``dagame'' trees (Callycophyllum...

  12. 78 FR 61003 - Endangered and Threatened Wildlife and Plants; Endangered Species Status for the Florida Bonneted...

    Science.gov (United States)

    2013-10-02

    ... black to brown to brownish-gray or cinnamon brown with ventral pelage (fur) paler than dorsal (Owre 1978... forested, suburban, and urban areas (Timm and Arroyo-Cabrales 2008, p. 1). Data from acoustical surveys and... roost sites were located in tree cavities, including woodpecker holes and cavities in royal palms...

  13. A Framework for Analyzing Evidence-Based Reasoning in Science Classroom Discourse

    Science.gov (United States)

    Furtak, Erin Marie; Hardy, Ilonca; Beinbrech, Christina; Shavelson, Richard J.; Shemwell, Jonathan T.

    2010-01-01

    This article adapts the Evidence-Based Reasoning (EBR) Framework (Brown, Furtak, Timms, Nagashima, & Wilson, this issue) to create a coding system for assessing argumentation in science classroom discourse. The instrument, "Evidence-Based Reasoning in Science Classroom Discourse", is intended to provide a means for measuring the quality of EBR in…

  14. Disease: H01201 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H01201 Jensen syndrome; Opticoacoustic nerve atrophy Jensen syndrome is X-linked deafness...rmalities. Causative mutations were identified within the deafness-dystonia peptide (TIMM8a) gene. Nervous s...e visual cortex is a prominent feature of the X-linked recessive mitochondrial deafness-dystonia syndrome ca

  15. The Evolution of the Automated Continuous Evaluation System (ACES) for Personnel Security

    Science.gov (United States)

    2013-11-12

    ACES results to the those from background investigations (Rome, Jr., & Chandler, 2005; Timm, Buck, & Chandler, 2004; Chandler & Jung , 2007...Richmond, Chandler, & Jung , 2008). TECHNICAL AND OPERATIONAL DESCRIPTION OF ACES VERSION ONE Since ACES constantly evolved to align with the needs of the...States • Foreign Influence • Foreign Preference • Sexual Behavior • Personal Conduct • Financial Considerations • Alcohol Consumption • Drug

  16. Histochemical distribution of zinc in the brain of the rainbow trout, Oncorhynchos myciss. I. The telencephalon

    DEFF Research Database (Denmark)

    Piñuela, C; Baatrup, E; Geneser, F A

    1992-01-01

    The present paper which describes the distribution of zinc in the telencephalon of the rainbow trout, Oncorhynchos myciss, is the first report on the distribution of a heavy metal in the fish brain. Zinc was demonstrated histochemically by silver enhancement using the Neo-Timm method. The staining...

  17. Teaching Mathematics That Addresses Learners' Multiple Intelligences

    Science.gov (United States)

    Gouws, E.; Dicker, A-M.

    2011-01-01

    To meet the demands of our highly technological and globally competitive society, it is becoming increasingly important for all learners in South Africa to obtain skills and knowledge in mathematics. However, South Africa performed the worst of all the countries who participated in the Trends in International Mathematics and Science Study (TIMMS).…

  18. Stratification of Living Organisms in Ballast Tanks: How Do Organism Concentrations Vary as Ballast Water is Discharged

    Science.gov (United States)

    2013-04-24

    generally motile and includes microinvertebrates, animal larvae, heterotrophic protists, and some microalgae (e.g., diatoms). Indeed, certain planktonic...1309−1318. (25) Stoecker, D. K. Particle production by planktonic ciliates. Limnol. Oceanogr. 1984, 29, 930−940. (26) Wörner, U.; Zimmerman-Timm, H

  19. Comparative study of teaching content in teacher education programmes in Canada, Denmark, Finland and Singapore

    DEFF Research Database (Denmark)

    Rasmussen, Jens; Bayer, Martin

    2014-01-01

    , Canada, Finland and Singapore, all of which score highly in international comparisons such as PISA and TIMMS, and on the other hand Denmark, which receives average scores, but it also functions as a comparison between all four countries. The study covers the following subjects: pedagogy and mathematics...

  20. Serial Cities: Australian Literary Cities and the Rhetoric of Scale

    Directory of Open Access Journals (Sweden)

    Brigid Rooney

    2015-03-01

    Sophie Cunningham, Melbourne (2011 Matthew Condon, Brisbane (2010 Paul Daley, Canberra (2012 Delia Falconer, Sydney (2010 Kerryn Goldsworthy, Adelaide (2011 Eleanor Hogan, Alice Springs (2012 Tess Lea, Darwin (2014 Peter Timms, In Search of Hobart (2012 David Whish-Wilson, Perth (2013

  1. EKSTRAGLIKEMIJSKI UČINCI LIRAGLUTIDA, ANALOGA HUMANOG GLUKAGONU SLIČNOG PEPTIDA-1

    OpenAIRE

    BULUM, TOMISLAV; DUVNJAK, LEA

    2017-01-01

    Glukagonu sličan peptid-1 (GLP-1) je probavni hormon koji stimulira lučenje inzulina u ovisnosti o razini glukoze. GLP-1 analog liraglutid ima 97 %-tnu sličnost ljudskom GLP-1 i ima učinke neovisne o regulaciji glikemije jer su receptori za GLP-1 široko rasprostranjeni po našem organizmu i to u srcu (uključujući vaskularni endotel i miokard), gastrointestinalnom sustavu, jetri, bubrezima, perifernom i centralnom živčanom sustavu. GLP-1 agonisti predstavljaju značajan napredak u liječenju š...

  2. Validation of Aura Microwave Limb Sounder HCl Measurements

    Science.gov (United States)

    Froidevaux, L.; Jiang, Y. B.; Lambert, A.; Livesey, N. J.; Read, W. G.; Waters, J. W.; Fuller, R. A.; Marcy, T. P.; Popp, P. J.; Gao, R. S.; hide

    2008-01-01

    The Earth Observing System (EOS) Microwave Limb Sounder (MLS) aboard the Aura satellite has provided daily global HCl profiles since August 2004. We provide a characterization of the resolution, random and systematic uncertainties, and known issues for the version 2.2 MLS HCl data. The MLS sampling allows for comparisons with many (1500 to more than 3000) closely matched profiles from the Halogen Occultation Experiment (HALOE) and Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS). These data sets provide HCl latitudinal distributions that are, overall, very similar to those from (coincident) MLS profiles, although there are some discrepancies in the upper stratosphere between the MLS and HALOE gradients. As found in previous work, MLS and ACE HCl profiles agree very well (within approximately 5%, on average), but the MLS HCl abundances are generally larger (by 10-20%) than HALOE HCl. The bias versus HALOE is unlikely to arise mostly from MLS, as a similar systematic bias (of order 15%) is not observed between average MLS and balloon-borne measurements of HCl, obtained over Fort Sumner, New Mexico, in 2004 and 2005. At the largest pressure (147 hPa) for MLS HCl, a high bias (approximately 0.2 ppbv) is apparent in analyses of low to midlatitude data versus in situ aircraft chemical ionization mass spectrometry (CIMS) HCl measurements from the Aura Validation Experiment (AVE) campaigns in 2004, 2005, and 2006; this bias is also observed in comparisons of MLS and aircraftHCl/O3 correlations. Good agreement between MLS and CIMS HCl is obtained at 100 to 68 hPa. The recommended pressure range for MLS HCl is from 100 to 0.15 hPa.

  3. Achieving Lower Nitrogen Balance and Higher Nitrogen Recovery Efficiency Reduces Nitrous Oxide Emissions in North America's Maize Cropping Systems

    Directory of Open Access Journals (Sweden)

    Rex A. Omonode

    2017-06-01

    Full Text Available Few studies have assessed the common, yet unproven, hypothesis that an increase of plant nitrogen (N uptake and/or recovery efficiency (NRE will reduce nitrous oxide (N2O emission during crop production. Understanding the relationships between N2O emissions and crop N uptake and use efficiency parameters can help inform crop N management recommendations for both efficiency and environmental goals. Analyses were conducted to determine which of several commonly used crop N uptake-derived parameters related most strongly to growing season N2O emissions under varying N management practices in North American maize systems. Nitrogen uptake-derived variables included total aboveground N uptake (TNU, grain N uptake (GNU, N recovery efficiency (NRE, net N balance (NNB in relation to GNU [NNB(GNU] and TNU [NNB(TNU], and surplus N (SN. The relationship between N2O and N application rate was sigmoidal with relatively small emissions for N rates <130 kg ha−1, and a sharp increase for N rates from 130 to 220 kg ha−1; on average, N2O increased linearly by about 5 g N per kg of N applied for rates up to 220 kg ha−1. Fairly strong and significant negative relationships existed between N2O and NRE when management focused on N application rate (r2 = 0.52 or rate and timing combinations (r2 = 0.65. For every percentage point increase, N2O decreased by 13 g N ha−1 in response to N rates, and by 20 g N ha−1 for NRE changes in response to rate-by-timing treatments. However, more consistent positive relationships (R2 = 0.73–0.77 existed between N2O and NNB(TNU, NNB(GNU, and SN, regardless of rate and timing of N application; on average N2O emission increased by about 5, 7, and 8 g N, respectively, per kg increase of NNB(GNU, NNB(TNU, and SN. Neither N source nor placement influenced the relationship between N2O and NRE. Overall, our analysis indicated that a careful selection of appropriate N rate applied at the right time can both increase NRE and reduce N

  4. In vivo hepatocyte MR imaging using lactose functionalized magnetoliposomes.

    Science.gov (United States)

    Ketkar-Atre, Ashwini; Struys, Tom; Dresselaers, Tom; Hodenius, Michael; Mannaerts, Inge; Ni, Yicheng; Lambrichts, Ivo; Van Grunsven, Leo A; De Cuyper, Marcel; Himmelreich, Uwe

    2014-01-01

    The aim of this study was to assess a novel lactose functionalized magnetoliposomes (MLs) as an MR contrast agent to target hepatocytes as well as to evaluate the targeting ability of MLs for in vivo applications. In the present work, 17 nm sized iron oxide cores functionalized with anionic MLs bearing lactose moieties were used for targeting the asialoglycoprotein receptor (ASGP-r), which is highly expressed in hepatocytes. Non-functionalized anionic MLs were tested as negative controls. The size distribution of lactose and anionic MLs was determined by transmission electron microscopy (TEM) and dynamic light scattering (DLS). After intravenous administration of both MLs, contrast enhancement in the liver was observed by magnetic resonance imaging (MRI). Label retention was monitored non-invasively by MRI and validated with Prussian blue staining and TEM for up to eight days post MLs administration. Although the MRI signal intensity did not show significant differences between functionalized and non-functionalized particles, iron-specific Prussian blue staining and TEM analysis confirmed the uptake of lactose MLs mainly in hepatocytes. In contrast, non-functionalized anionic MLs were mainly taken up by Kupffer and sinusoidal cells. Target specificity was further confirmed by high-resolution MR imaging of phantoms containing isolated hepatocytes, Kupffer cell (KCs) and hepatic stellate cells (HSCs) fractions. Hypointense signal was observed for hepatocytes isolated from animals which received lactose MLs but not from animals which received anionic MLs. These data demonstrate that galactose-functionalized MLs can be used as a hepatocyte targeting MR contrast agent to potentially aid in the diagnosis of hepatic diseases if the non-specific uptake by KCs is taken into account. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. Medical laboratory scientist

    DEFF Research Database (Denmark)

    Smith, Julie; Qvist, Camilla Christine; Jacobsen, Katja Kemp

    2017-01-01

    to offer biomarker research compared with other academic professions? Will the new graduates possess sufficient research skills? It may be hard to be ‘the new boy in class’ in a competitive research environment; however, by reinforcing the educational program, the MLS may become important partners...... and application? The current MLS education has now moved far away from the former technician’s apprenticeship, and the Danish MLS bachelor educational program is focusing strongly on teaching research skills related to biomarker development and personalized medicine. Do MLS graduates have anything different...

  6. A Network Version of the Pump

    National Research Council Canada - National Science Library

    Kang, Myong H; Moskowitz, Ira S; Lee, Daniel C

    1995-01-01

    A designer of reliable MLS networks must consider covert channels and denial of service attacks in addition to traditional network performance measures such as throughput, fairness, and reliability...

  7. Validation of Aura Microwave Limb Sounder Ozone by Ozonesonde and Lidar Measurements

    Science.gov (United States)

    Jiang, Y. B.; Froidevaux, L.; Lambert, A.; Livesey, N. J.; Read, W. G.; Waters, J. W.; Bojkov, B.; Leblanc, T.; McDermid, I. S.; Godin-Beekmann, S.; hide

    2007-01-01

    We present validation studies of MLS version 2.2 upper tropospheric and stratospheric ozone profiles using ozonesonde and lidar data as well as climatological data. Ozone measurements from over 60 ozonesonde stations worldwide and three lidar stations are compared with coincident MLS data. The MLS ozone stratospheric data between 150 and 3 hPa agree well with ozonesonde measurements, within 8% for the global average. MLS values at 215 hPa are biased high compared to ozonesondes by approximately 20% at middle to high latitude, although there is a lot of variability in this altitude region.

  8. The impact of computer use in the development of Mathematics teaching in primary education

    OpenAIRE

    Alawadhi, Nabil

    2011-01-01

    This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University. The educational system in Kuwait is intended to provide primary and secondary students with required skills in order to operate in the technical careers commonly undertaken. However, mathematics education lags significantly behind other countries in Kuwait. In the 1997 and 2008 TIMMS international studies of primary and secondary mathematics achievement, Kuwait ranked near the bottom on almos...

  9. Evaluation of DNA Repair Function as a Predictor of Response in a Clinical Trial of PARP Inhibitor Monotherapy for Recurrent Ovarian Carcinoma

    Science.gov (United States)

    2016-12-01

    treatment and maintenance settings, in metastatic breast cancer patients with a germline BRCA (gBRCA) mutation and in relapsed HGSOC patients (both BRCA... Predisposition for Breast and Ovarian Cancer . Mayo Clin Proc 2010;85:1111-20. 4. Hennessy BTJ, Timms KM, Carey MS, et al. Somatic Mutations in BRCA1...identify ovarian cancer patients likely to respond to rucaparib using tumor genetic analysis, : Iain McNeish, Amit Oza, Robert L. Coleman, Clare

  10. Immersion autometallography: histochemical in situ capturing of zinc ions in catalytic zinc-sulfur nanocrystals.

    Science.gov (United States)

    Danscher, Gorm; Stoltenberg, Meredin; Bruhn, Mikkel; Søndergaard, Chris; Jensen, Dorete

    2004-12-01

    In the mid-1980s, two versions of Timm's original immersion sulfide silver method were published. The authors used immersion of tissue in a sulfide solution as opposed to Timm, who used immersion of tissue blocks in hydrogen sulfide-bubbled alcohol. The autometallography staining resulting from the "sulfide only immersion" was not particularly impressive, but the significance of this return to an old approach became obvious when Wenzel and co-workers presented their approach in connection with introduction by the Palmiter group of zinc transporter 3 (ZnT3). The Wenzel/Palmiter pictures are the first high-resolution, high-quality pictures taken from tissues in which free and loosely bound zinc ions have been captured in zinc-sulfur nanocrystals by immersion. The trick was to place formalin-fixed blocks of mouse brains in a solution containing 3% glutaraldehyde and 0.1% sodium sulfide, ingredients used for transcardial perfusion in the zinc-specific NeoTimm method. That the NeoTimm technique results in silver enhancement of zinc-sulfur nanocrystals has been proved by proton-induced X-ray multielement analyses (PIXE) and in vivo chelation with diethyldithiocarbamate (DEDTC). The aims of the present study were (a) to make the immersion-based capturing of zinc ions in zinc-sulfur nanocrystals work directly on sections and slices of fixed brain tissue, (b) to work out protocols that ensure zinc specificity and optimal quality of the staining, (c) to apply "immersion autometallography" (iZnSAMG) to other tissues that contain zinc-enriched (ZEN) cells, and (d) to make the immersion approach work on unfixed fresh tissue.

  11. A CRISPR-based MLST Scheme for Understanding the Population Biology and Epidemiology of Salmonella Enterica

    Science.gov (United States)

    2015-05-26

    N. Shariat, R. E. Timme, J. B. Pettengill, R. Barrangou, E. G. Dudley. Characterization and evolution of Salmonella CRISPR - Cas systems...Barrangou, Edward G. Dudley. Characterization of CRISPR - Cas in Salmonella, 3rd European CRISPR meeting. 14-MAY-14, . : , Margaret K. Kirchner, Nikki... CRISPRs Beyond subtyping approaches, we were motivated to understand the biology of CRISPR - Cas systems in Salmonella. We performed in-depth sequence

  12. Trabajo de doctorado: recuperación de información orientada a la minería de opiniones

    OpenAIRE

    Fernández Martínez, Javier; Gómez Soriano, José Manuel; Martínez Barco, Patricio

    2011-01-01

    Un sistema de recuperación de información orientado a la minería de opiniones, en el que se investiguen las influencias positivas entre las tres áreas que abarca: recuperación de información, rastreo web y minería de opiniones. Comunicación presentada en las IV Jornadas TIMM, Torres (Jaén), 7-8 abril 2011.

  13. Les traductions néerlandaises des romans francophones camerounais

    African Journals Online (AJOL)

    28 mars 2016 ... ”Tradução e utopia póscolonial a intervenção invisível de Saramago.” “O que transforma o mundo é a necessidade e não a utopia”: Estudos sobre utopia e ficção em José Saramago. Ed. Burghar Baltrusch. Berlin: Frank & Timme GmbH, 2014. 73–93. Heilbron, Johan. “Towards a sociology of translation.

  14. Les traductions néerlandaises des romans francophones camerounais

    African Journals Online (AJOL)

    28 mars 2016 ... mundo é a necessidade e não a utopia”: Estudos sobre utopia e ficção em José Saramago. Ed. Burghar Baltrusch. Berlin: Frank & Timme GmbH, 2014. 73–93. Heilbron, Johan. “Towards a sociology of translation. Book translations as a cultural world system.” European Journal of Social Theory 2.4 (1999): ...

  15. Deparaffination time: a crucial point in histochemical detection of tissue copper

    Directory of Open Access Journals (Sweden)

    S Nemolato

    2009-08-01

    Full Text Available The search for a sensitive histochemical method for revealing tissue copper has been the object of many workers in the past. In spite of multiple methods available, the occurrence in clinical practice of negative histochemical stains, even in cases with high copper levels demonstrated by quantitative methods is very high. This study was aimed at verifying the role of technical variations in the sensitivity of the Timm method and, in particular, the role of the dewaxing time of paraffin sections. To this end, 15 liver specimens, 10 from patients affected by Wilson’s disease and 5 newborn livers were fixed in 10% formalin, paraffin embedded and routinaly processed. Four 4-micron sections from each case were rinsed in xylene for 10, 20, 60 min, and for 24 hrs. All sections were stained with Timm’s method. In 13 out of the 15 liver biopsies utilized in this study, the sensitivity of Timm’s method in revealing copper deposits in liver cells appeared to be dependent on the dewaxing time. In two other cases, reactivity of copper granules to Timm solution did not change significantly with the different deparaffination times. The best results were obtained by rinsing sections in xylene for 24 hrs, the worst in sections treated with xylen for 10 minutes. In particular, in five cases of Wilson’s disease, Timm stain applied to sections following ten minutes of xylene were completely negative, while copper granules were clearly evidenced in the same section following an overnight bath in xylene. Our data show that an overnight bath of paraffin sections in xylene may completely change the sensitivity of Timm stain in revealing copper deposits in the liver, relaunching copper histochemistry in the diagnosis of copper-related liver diseases.

  16. Multi-Level Security Cannot Realise NEC Objectives

    NARCIS (Netherlands)

    Schotanus, H.A.; Hartog, T.; Verkoelen, C.A.A.

    2012-01-01

    Multi-Level Security (MLS) is often viewed as the holy grail of information security, especially in those environments where information of different classifications is being processed. In this paper we argue that MLS cannot facilitate the right balance between need-to-protect and duty-to-share as

  17. 14 CFR 171.311 - Signal format requirements.

    Science.gov (United States)

    2010-01-01

    ... second in order to protect against synchronous interference. One such combination of sequences is shown... which contains the MLS datum point. (iii) Approach azimuth alignment with runway centerline shall... centerline which contains the MLS datum point. (xii) Back azimuth antenna alignment with runway centerline...

  18. Virtual and Traditional Slides for Teaching Cellular Morphology to Medical Laboratory Science Undergraduates: A Comparative Study of Performance Outcomes, Retention, and Self-Efficacy Beliefs

    Science.gov (United States)

    Solberg, Brooke L.

    2011-01-01

    As a result of massive retirement and educational program expense and closure, the field of Medical Laboratory Science (MLS) is facing a critical workforce shortage. Combatting this issue by increasing undergraduate class size is a difficult proposition due to the intense psychomotor curricular requirements of MLS programs. Technological advances…

  19. Assessment of commercially packaged water for faecal bacterial ...

    African Journals Online (AJOL)

    Of the 48 sachet water analyzed, 2 (4.2%) were positive for Presumptive Coliform Count (PCC) with the first and second water samples showing a count of 160 MPN/l00mls and 30MPN/100mls respectively. All the bottled water analyzed were negative for PCC. Since the need for consumption of packaged water cannot be ...

  20. Technical Requirements for Benchmark Simulator-Based Terminal Instrument Procedures (TERPS) Evaluation.

    Science.gov (United States)

    1986-05-01

    the MLS coverage. Table 3 shows the differences in ground track positions between the conical MLS and a planer system for various values of azimuth...landing pads. There is also a 400:1 scale aircraft carrier that has pitch, roll and heave capabilities controlled by the digital computer. The VFA-02

  1. Idiopathic pericardial effusion in 2 year old labrador managed with ...

    African Journals Online (AJOL)

    Ultrasound-guided pericardiocentesis was carried out using a 16 gauge over the needle catheter attached to a 3-way stopcock and a 20mls syringe; about 65mls of clear effusate was aspirated. Laboratory analysis of the effusate revealed that it was a transudate. The patient was placed on 3mg/kg furosemide, twice daily for ...

  2. file 7

    African Journals Online (AJOL)

    Farming and trading are the major from a sampling frame of thirty-four economic activities. ... The urine specimens were collected between The urine sedimentation technique was used the hours of 10:00 AM and .... Note: Heavy intensity infection (= 50 eggs per 10 mls of urine); Low intensity infection. (<50 eggs per 10 mls ...

  3. Low level of stratospheric ozone near the Jharia coal field in India

    Indian Academy of Sciences (India)

    Although air pollution due to oxides and dioxides of carbon, nitrogen and sulphur is reported to have increased in this area due to large-scale opencast mining and ... data obtained from Upper Atmospheric Research Satellite (UARS MLS), Earth Observing System Microwave Limb Sounder (EOS MLS) and Ozone Monitoring ...

  4. 14 CFR 171.303 - Definitions.

    Science.gov (United States)

    2010-01-01

    ...-left or fly-right indication of the direction relative to the approach course the aircraft should... means the inability of an item to perform within previously specified limits. Guard time means an unused.... Microwave Landing System (MLS) means the MLS selected by ICAO for international standardization. Minimum...

  5. Magnetic design consideration of a Magnetic Lead Screw with Halbach Array

    DEFF Research Database (Denmark)

    Holm, Rasmus Koldborg; Berg, Nick Ilsø; Rasmussen, Peter Omand

    This paper presents the novel design of a Magnetic Lead Screw (MLS) with magnetic thread of Halbach Arrays. The MLS where designed and build, tests indicated a stall force which where 12 % lower than calculated in 3D FE. This is explained by demagnetization of the magnet during stall, the behavio...

  6. The Pattern and Outcome of Chest Injuries in South West Nigeria

    African Journals Online (AJOL)

    ing traumatic pleural collections as well as inserting chest tubes. Thoracotomy is indicated especially when chest tube output exceeds 250 mls per hour for up to 3 hours, or an initial chest tube output of >1000mls (16). Only 5 of our patients required this and all but one were due to penetrating injury. The findings at surgery ...

  7. Evaluation of the InnoTyper® 21 genotyping kit in multi-ethnic populations

    DEFF Research Database (Denmark)

    Ristow, Peter Gustav; Barnes, Nicole; Murphy, Gina Pineda

    2017-01-01

    We report the findings of the evaluation of the InnoTyper® 21 genotyping kit for the use of human identification (HID) and paternity testing in South Africa. This novel forensic kit evaluates 20 retrotransposable elements (AC4027, MLS26, ALU79712, NBC216, NBC106, RG148, NBC13, AC2265, MLS09, AC1141...

  8. Revisit Of Current Patterns Of Semen Quality Among Male Partners ...

    African Journals Online (AJOL)

    About 61% of the patients produced semen by coitus interruptus while, 34.3% obtained their samples by masturbation. Majority of the patients (70.1%) produced semen volume of greater than 2mls, while 29.9% produced semen of less than 2mls. Of the total number, 34.7% were normozoospermia while, 65.3% had one ...

  9. Ultrasmall superparamagnetic iron oxide (USPIO)-based liposomes as magnetic resonance imaging probes.

    Science.gov (United States)

    Frascione, Daniela; Diwoky, Clemens; Almer, Gunter; Opriessnig, Peter; Vonach, Caroline; Gradauer, Kerstin; Leitinger, Gerd; Mangge, Harald; Stollberger, Rudolf; Prassl, Ruth

    2012-01-01

    Magnetic liposomes (MLs) are phospholipid vesicles that encapsulate magnetic and/or paramagnetic nanoparticles. They are applied as contrast agents for magnetic resonance imaging (MRI). MLs have an advantage over free magnetic nanocores, in that various functional groups can be attached to the surface of liposomes for ligand-specific targeting. We have synthesized PEG-coated sterically-stabilized magnetic liposomes (sMLs) containing ultrasmall superparamagnetic iron oxides (USPIOs) with the aim of generating stable liposomal carriers equipped with a high payload of USPIOs for enhanced MRI contrast. Regarding iron oxide nanoparticles, we have applied two different commercially available surface-coated USPIOs; sMLs synthesized and loaded with USPIOs were compared in terms of magnetization and colloidal stability. The average diameter size, morphology, phospholipid membrane fluidity, and the iron content of the sMLs were determined by dynamic light scattering (DLS), transmission electron microscopy (TEM), fluorescence polarization, and absorption spectroscopy, respectively. A colorimetric assay using potassium thiocyanate (KSCN) was performed to evaluate the encapsulation efficiency (EE%) to express the amount of iron enclosed into a liposome. Subsequently, MRI measurements were carried out in vitro in agarose gel phantoms to evaluate the signal enhancement on T1- and T2-weighted sequences of sMLs. To monitor the biodistribution and the clearance of the particles over time in vivo, sMLs were injected in wild type mice. DLS revealed a mean particle diameter of sMLs in the range between 100 and 200 nm, as confirmed by TEM. An effective iron oxide loading was achieved just for one type of USPIO, with an EE% between 74% and 92%, depending on the initial Fe concentration (being higher for lower amounts of Fe). MRI measurements demonstrated the applicability of these nanostructures as MRI probes. Our results show that the development of sMLs is strictly dependent on the

  10. Informační bezpečnost jako ukazatel výkonnosti podniku

    OpenAIRE

    Gancarčik, Rastislav

    2017-01-01

    Obsahom tejto diplomovej práce je návrh metodického postupu pre hodnotenie výkonnosti podniku z pohľadu informačnej bezpečnosti, pričom táto výkonnosť sa posudzuje na základe splnenia noriem ISO/IEC 27001:2013, zákona č. 181/2014 Sb., nariadenia Európskeho parlamentu č. 2016/679 a smernice Európskeho parlamentu č. 2016/1148. Návrh tohto metodického postupu je spracovaný pre konkrétnu spoločnosť pôsobiacu v Českej republike. The content of this thesis is a proposal of methodology for evalua...

  11. Perceiving the Crust in 3-D: A Model Integrating Geological, Geochemical, and Geophysical Data

    Science.gov (United States)

    Strati, Virginia; Wipperfurth, Scott A.; Baldoncini, Marica; McDonough, William F.; Mantovani, Fabio

    2017-12-01

    Regional characterization of the continental crust has classically been performed through either geologic mapping, geochemical sampling, or geophysical surveys. Rarely are these techniques fully integrated, due to limits of data coverage, quality, and/or incompatible data sets. We combine geologic observations, geochemical sampling, and geophysical surveys to create a coherent 3-D geologic model of a 50 × 50 km upper crustal region surrounding the SNOLAB underground physics laboratory in Canada, which includes the Southern Province, the Superior Province, the Sudbury Structure, and the Grenville Front Tectonic Zone. Nine representative aggregate units of exposed lithologies are geologically characterized, geophysically constrained, and probed with 109 rock samples supported by compiled geochemical databases. A detailed study of the lognormal distributions of U and Th abundances and of their correlation permits a bivariate analysis for a robust treatment of the uncertainties. A downloadable 3-D numerical model of U and Th distribution defines an average heat production of 1.5-0.7+1.4 µW/m3, and predicts a contribution of 7.7-3.0+7.7 TNU (a Terrestrial Neutrino Unit is one geoneutrino event per 1032 target protons per year) out of a crustal geoneutrino signal of 31.1-4.5+8.0 TNU. The relatively high local crust geoneutrino signal together with its large variability strongly restrict the SNO+ capability of experimentally discriminating among BSE compositional models of the mantle. Future work to constrain the crustal heat production and the geoneutrino signal at SNO+ will be inefficient without more detailed geophysical characterization of the 3-D structure of the heterogeneous Huronian Supergroup, which contributes the largest uncertainty to the calculation.

  12. Promoting Therapists' Use of Motor Learning Strategies within Virtual Reality-Based Stroke Rehabilitation.

    Science.gov (United States)

    Levac, Danielle E; Glegg, Stephanie M N; Sveistrup, Heidi; Colquhoun, Heather; Miller, Patricia; Finestone, Hillel; DePaul, Vincent; Harris, Jocelyn E; Velikonja, Diana

    2016-01-01

    Therapists use motor learning strategies (MLSs) to structure practice conditions within stroke rehabilitation. Virtual reality (VR)-based rehabilitation is an MLS-oriented stroke intervention, yet little support exists to assist therapists in integrating MLSs with VR system use. A pre-post design evaluated a knowledge translation (KT) intervention incorporating interactive e-learning and practice, in which 11 therapists learned how to integrate MLSs within VR-based therapy. Self-report and observer-rated outcome measures evaluated therapists' confidence, clinical reasoning and behaviour with respect to MLS use. A focus group captured therapists' perspectives on MLS use during VR-based therapy provision. The intervention improved self-reported confidence about MLS use as measured by confidence ratings (p Learning Strategy Rating Instrument, no behaviour change with respect to MLS use was noted (p = 0.092). Therapists favoured the strategy of transferring skills from VR to real-life tasks over employing a more comprehensive MLS approach. The KT intervention improved therapists' confidence but did not have an effect on clinical reasoning or behaviour with regard to MLS use during VR-based therapy.

  13. Promoting Therapists’ Use of Motor Learning Strategies within Virtual Reality-Based Stroke Rehabilitation

    Science.gov (United States)

    Levac, Danielle E.; Glegg, Stephanie M. N.; Sveistrup, Heidi; Colquhoun, Heather; Miller, Patricia; Finestone, Hillel; DePaul, Vincent; Harris, Jocelyn E.; Velikonja, Diana

    2016-01-01

    Purpose Therapists use motor learning strategies (MLSs) to structure practice conditions within stroke rehabilitation. Virtual reality (VR)-based rehabilitation is an MLS-oriented stroke intervention, yet little support exists to assist therapists in integrating MLSs with VR system use. Method A pre-post design evaluated a knowledge translation (KT) intervention incorporating interactive e-learning and practice, in which 11 therapists learned how to integrate MLSs within VR-based therapy. Self-report and observer-rated outcome measures evaluated therapists’ confidence, clinical reasoning and behaviour with respect to MLS use. A focus group captured therapists’ perspectives on MLS use during VR-based therapy provision. Results The intervention improved self-reported confidence about MLS use as measured by confidence ratings (p Learning Strategy Rating Instrument, no behaviour change with respect to MLS use was noted (p = 0.092). Therapists favoured the strategy of transferring skills from VR to real-life tasks over employing a more comprehensive MLS approach. Conclusion The KT intervention improved therapists’ confidence but did not have an effect on clinical reasoning or behaviour with regard to MLS use during VR-based therapy. PMID:27992492

  14. High-Throughput Screening of Myxoid Liposarcoma Cell Lines: Survivin Is Essential for Tumor Growth

    Directory of Open Access Journals (Sweden)

    Marieke A. de Graaff

    2017-08-01

    Full Text Available Myxoid liposarcoma (MLS is a soft tissue sarcoma characterized by a recurrent t(12;16 translocation. Although tumors are initially radio- and chemosensitive, the management of inoperable or metastatic MLS can be challenging. Therefore, our aim was to identify novel targets for systemic therapy. We performed an in vitro high-throughput drug screen using three MLS cell lines (402091, 1765092, DL-221, which were treated with 273 different drugs at four different concentrations. Cell lines and tissue microarrays were used for validation. As expected, all cell lines revealed a strong growth inhibition to conventional chemotherapeutic agents, such as anthracyclines and taxanes. A good response was observed to compounds interfering with Src and the mTOR pathway, which are known to be affected in these tumors. Moreover, BIRC5 was important for MLS survival because a strong inhibitory effect was seen at low concentration using the survivin inhibitor YM155, and siRNA for BIRC5 decreased cell viability. Immunohistochemistry revealed abundant expression of survivin restricted to the nucleus in all 32 tested primary tumor specimens. Inhibition of survivin in 402-91 and 1765-92 by YM155 increased the percentage S-phase but did not induce apoptosis, which warrants further investigation before application in the treatment of metastatic MLS. Thus, using a 273-compound drug screen, we confirmed previously identified targets (mTOR, Src in MLS and demonstrate survivin as essential for MLS survival.

  15. Highly significant linkage to chromosome 3q13.31 for rhinitis and related allergic diseases

    DEFF Research Database (Denmark)

    Brasch-Andersen, C; Haagerup, A; Borglum, AD

    2006-01-01

    to chromosome 3q13.31 for rhinitis (MLS 5.55, identity by descent (IBD) 63.9%) and atopy (increased specific immunoglobulin E) (MLS 3.71, IBD 61.7%). We obtained an MLS of 5.1 (IBD 67.3%) at 3q13.31 when sib pairs with both rhinitis and atopy were analysed. CONCLUSION: This study reports the first statistically...... significant evidence for a genetic susceptibility locus for rhinitis and to our knowledge shows the most significant evidence to date of linkage for any allergy phenotype....

  16. Resistance to the tetracyclines and macrolide-lincosamide-streptogramin group of antibiotics and its genetic linkage - a review.

    Science.gov (United States)

    Marosevic, Durdica; Kaevska, Marija; Jaglic, Zoran

    2017-06-12

    An excessive use of antimicrobial agents poses a risk for the selection of resistant bacteria. Of particular interest are antibiotics that have large consumption rates in both veterinary and human medicine, such as the tetracyclines and macrolide-lincosamide-streptogramin (MLS) group of antibiotics. A high load of these agents increases the risk of transmission of resistant bacteria and/or resistance determinants to humans, leading to a subsequent therapeutic failure. An increasing incidence of bacteria resistant to both tetracyclines and MLS antibiotics has been recently observed. This review summarizes the current knowledge on different tetracycline and MLS resistance genes that can be linked together on transposable elements.

  17. Characterization of molybdenum/silicon X-ray multilayers

    CERN Document Server

    Nayak, M; Lodha, G S; Shrivastava, A K; Tripathi, P; Sinha, A K; Sawhney, K J S; Nandedkar, R V

    2003-01-01

    Mo/Si multilayers (MLs) with variable Mo thickness were fabricated using electron beam evaporator. Percolation thickness for Mo was determined experimentally. MLs with Mo thickness below percolation show low reflectivity due to discontinuous nature of Mo film. As the number of layer pair increases, the interfacial roughness increases, due to increase in correlated roughness. Extreme ultra violet reflectivity was measured using synchrotron radiation. The fitting result reveals that the graded interface layer exists at each interface. Cross-sectional transmission electron microscopy has been done on some of these MLs.

  18. News

    OpenAIRE

    News, Transfer

    2017-01-01

      NOTICIAS / NEWS (“transfer”, 2018)  1) LIBROS – CAPÍTULOS DE LIBRO  / BOOKS – BOOK CHAPTERS 1. Bandia, Paul F. (ed.). (2017). Orality and Translation.  London: Routledge.   2. Trends in Translation and Interpretin,  Institute of Translation & Interpreting 3. Schippel, Larisa & Cornelia Zwischenberger. (eds). (2017). Going East: Discovering New and Alternative Traditions in Translation Studies. Berlin: Frank & Timme. 4.  Godayol, Pilar. (2017). Tres escritoras censuradas: Simone de Beauvoir,...

  19. A Strategy for Improving US Middle School Student Mathematics Word Problem Solving Performance

    Science.gov (United States)

    Thomas, Valerie L.

    2004-01-01

    U.S. middle school students have difficulty understanding and solving mathematics word problems. Their mathematics performance on the Third International Mathematics and Science Study (TIMMS) is far below their international peers, and minority students are less likely than high socioeconomic status (SES) White/Asian students to be exposed to higher-level mathematics concepts. Research literature also indicates that when students use both In-School and Out-of-School knowledge and experiences to create authentic mathematics word problems, student achievement improves. This researcher developed a Strategy for improving mathematics problem solving performance and a Professional Development Model (PDM) to effectively implement the Strategy.

  20. Islamic Fundamentalism in South Asia

    Science.gov (United States)

    2007-08-20

    card from NYU and said I had come to do research. I didn’t elaborate. He asked where I was staying. I gave him the hotel name. He stamped my passport...Christian) calendars. “Timeo hominum unius libris,” said Father Timm, speaking in Latin. “I fear the man of one book.” It is a Roman saying. He...for girls. It was a brick building, and there were no windows. “All our problems would be solved in Pakistan,” said the lawyer, “if we created a

  1. Briefing paper : toward a best practice model for managed lanes in Texas.

    Science.gov (United States)

    2013-09-01

    Over the past two decades, agencies : have increasingly implemented managed : lanes (MLs) to mitigate growing urban traffic : congestion in the United States. Multiple operating : projects : representing a combination : of HOV-to-HOT conversions a...

  2. A Multilevel Secure Workflow Management System

    National Research Council Canada - National Science Library

    Kang, Myong H; Froscher, Judith N; Sheth, Amit P; Kochut, Krys J; Miller, John A

    1999-01-01

    The Department of Defense (DoD) needs multilevel secure (MLS) workflow management systems to enable globally distributed users and applications to cooperate across classification levels to achieve mission critical goals...

  3. A CyberCIEGE Scenario To Illustrate Classified Information Management in Multilevel Secure Systems for Military Command and Control

    National Research Council Canada - National Science Library

    Mum, Ng C

    2005-01-01

    .... This research developed a scenario definition file for the CyberCIEGE game engine to illustrate and train players on matters related to information protection using compartmentalized Mutlilevel Secure (MLS) systems...

  4. Tunable, High-Power Terahertz Quantum Cascade Laser Local Oscillator, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA and NASA funded missions/instruments such as Aura/MLS (Microwave Limb Sounder), SOFIA/GREAT and STO/STO-2 have demonstrated the need for local oscillator (LO)...

  5. Terahertz Quantum Cascade Laser Local Oscillator, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA and NASA funded missions/instruments such as Aura (EOS CH-1)/MLS (Microwave Limb Sounder), SOFIA/GREAT and STO have demonstrated the need for local oscillator...

  6. Methane Liquid Level Sensor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced Technologies Group, Inc. proposes the development of a Methane Liquid-Level Sensor, (MLS) for In-Space cryogenic storage capable of continuous monitoring of...

  7. NASA-FAA helicopter Microwave Landing System curved path flight test

    Science.gov (United States)

    Swenson, H. N.; Hamlin, J. R.; Wilson, G. W.

    1984-01-01

    An ongoing series of joint NASA/FAA helicopter Microwave Landing System (MLS) flight tests was conducted at Ames Research Center. This paper deals with tests done from the spring through the fall of 1983. This flight test investigated and developed solutions to the problem of manually flying curved-path and steep glide slope approaches into the terminal area using the MLS and flight director guidance. An MLS-equipped Bell UH-1H helicopter flown by NASA test pilots was used to develop approaches and procedures for flying these approaches. The approaches took the form of Straight-in, U-turn, and S-turn flightpaths with glide slopes of 6 deg, 9 deg, and 12 deg. These procedures were evaluated by 18 pilots from various elements of the helicopter community, flying a total of 221 hooded instrument approaches. Flying these curved path and steep glide slopes was found to be operationally acceptable with flight director guidance using the MLS.

  8. Classification of Mobile Laser Scanning Point Clouds from Height Features

    Science.gov (United States)

    Zheng, M.; Lemmens, M.; van Oosterom, P.

    2017-09-01

    The demand for 3D maps of cities and road networks is steadily growing and mobile laser scanning (MLS) systems are often the preferred geo-data acquisition method for capturing such scenes. Because MLS systems are mounted on cars or vans they can acquire billions of points of road scenes within a few hours of survey. Manual processing of point clouds is labour intensive and thus time consuming and expensive. Hence, the need for rapid and automated methods for 3D mapping of dense point clouds is growing exponentially. The last five years the research on automated 3D mapping of MLS data has tremendously intensified. In this paper, we present our work on automated classification of MLS point clouds. In the present stage of the research we exploited three features - two height components and one reflectance value, and achieved an overall accuracy of 73 %, which is really encouraging for further refining our approach.

  9. NLM MedlinePlus Magazine Team | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... Home Current issue contents Magazine Team Follow us Magazine Team National Library of Medicine at the National ... MLS, MA TREASURER Dennis Cryer, MD NIH MedlinePlus magazine is published by Friends of the NLM in ...

  10. Cost-effectiveness analysis of establishing a distance-education ...

    African Journals Online (AJOL)

    MLS); micro-resources centers WITHOUT video conferencing in five health centers and four regional hospitals (MRC-VC); micro resources centers WITH video conferencing in five health centers and four regional hospitals (MRC+VC); centralized ...

  11. A preliminary study on semen collection, evaluation and ...

    African Journals Online (AJOL)

    It was evaluated based on volume, mass motility, live-dead-ratio and sperm concentration, which were; 0.195 + 0.010mls (Tom 1) and 0.205 + 0.024mls (Tom 2), (+++) for both toms, 70% (for Tom 1) and 75% (for Tom 2) approximately and 6.150 ± 0.329 x109/ml and 6.295 ± 0.161 x109/ml for Tom1 and Tom 2 respectively.

  12. Brain activation to negative stimuli mediates a relationship between adolescent marijuana use and later emotional functioning

    OpenAIRE

    Mary M. Heitzeg; Lora M. Cope; Meghan E. Martz; Jillian E. Hardee; Robert A. Zucker

    2015-01-01

    This work investigated the impact of heavy marijuana use during adolescence on emotional functioning, as well as the brain functional mediators of this effect. Participants (n = 40) were recruited from the Michigan Longitudinal Study (MLS). Data on marijuana use were collected prospectively beginning in childhood as part of the MLS. Participants were classified as heavy marijuana users (n = 20) or controls with minimal marijuana use. Two facets of emotional functioning—negative emotionality a...

  13. Comparison of Response Surface Construction Methods for Derivative Estimation Using Moving Least Squares, Kriging and Radial Basis Functions

    Science.gov (United States)

    Krishnamurthy, Thiagarajan

    2005-01-01

    Response construction methods using Moving Least Squares (MLS), Kriging and Radial Basis Functions (RBF) are compared with the Global Least Squares (GLS) method in three numerical examples for derivative generation capability. Also, a new Interpolating Moving Least Squares (IMLS) method adopted from the meshless method is presented. It is found that the response surface construction methods using the Kriging and RBF interpolation yields more accurate results compared with MLS and GLS methods. Several computational aspects of the response surface construction methods also discussed.

  14. Validation of Aura Microwave Limb Sounder stratospheric water vapor measurements by the NOAA frost point hygrometer

    Science.gov (United States)

    Hurst, Dale F.; Lambert, Alyn; Read, William G.; Davis, Sean M.; Rosenlof, Karen H.; Hall, Emrys G.; Jordan, Allen F.; Oltmans, Samuel J.

    2017-01-01

    Differences between stratospheric water vapor measurements by NOAA frost point hygrometers (FPHs) and the Aura Microwave Limb Sounder (MLS) are evaluated for the period August 2004 through December 2012 at Boulder, Colorado, Hilo, Hawaii, and Lauder, New Zealand. Two groups of MLS profiles coincident with the FPH soundings at each site are identified using unique sets of spatiotemporal criteria. Before evaluating the differences between coincident FPH and MLS profiles, each FPH profile is convolved with the MLS averaging kernels for eight pressure levels from 100 to 26 hPa (~16 to 25 km) to reduce its vertical resolution to that of the MLS water vapor retrievals. The mean FPH – MLS differences at every pressure level (100 to 26 hPa) are well within the combined measurement uncertainties of the two instruments. However, the mean differences at 100 and 83 hPa are statistically significant and negative, ranging from −0.46 ± 0.22 ppmv (−10.3 ± 4.8%) to −0.10 ± 0.05 ppmv (−2.2 ± 1.2%). Mean differences at the six pressure levels from 68 to 26 hPa are on average 0.8% (0.04 ppmv), and only a few are statistically significant. The FPH – MLS differences at each site are examined for temporal trends using weighted linear regression analyses. The vast majority of trends determined here are not statistically significant, and most are smaller than the minimum trends detectable in this analysis. Except at 100 and 83 hPa, the average agreement between MLS retrievals and FPH measurements of stratospheric water vapor is better than 1%. PMID:28845378

  15. Willingness to Pay for Beef Quality Attributes: Combining Mixed Logit and Latent Segmentation Approach

    OpenAIRE

    Chung, Chanjin; Briggeman, Brian C.; Han, Sungill

    2008-01-01

    This study develops an alternative way of identifying the heterogeneity of WTP estimates for product attributes. The alternative approach combines mixed logit models with a latent segmentation method (MLS). First, the combined MLS approach estimates a mixed logit model and retrieve individual specific parameter estimates based on individual specific posterior distribution derived from the individual sequence of observed choices in the conjoint experiments. Second, WTPs of each choice variable...

  16. Preliminary Analysis of a Trusted Platform Module (TPM) Initialization Process

    Science.gov (United States)

    2007-06-01

    e.g., Windows 2000/XP and RedHat Linux), switches and Cisco VPN appliances, and various software including Commercial-off-the- shelf (COTS) such as...and SAMBA, “Stateless” MLS LAN clients with persistent data and metadata stored on the MLS Server, and IPsec -based dynamic security services [40]. A...R. Perez and R. Sailer, "Linking remote attestation to secure tunnel endpoints," in Proceedings of the First ACM Workshop on Scalable Trusted

  17. Space-based measurements of HCl: Intercomparison and historical context

    Science.gov (United States)

    Lary, D. J.; Aulov, O.

    2008-08-01

    The peak in stratospheric HCl was reached in the late 1990s. Between 1998 and 2004 the stratospheric loading of HCl was relatively constant, with some month to month fluctuation; this was followed by a more pronounced decrease in HCl since 2004. We use probability distribution functions (PDFs) and scatter diagrams for validation and bias characterization of Aura Microwave Limb Sounder (MLS) HCl retrievals. Both these methods allow us to use large statistical samples and do not require correlative measurements to be colocated in space and time. The bias between the Halogen Occultation Experiment (HALOE) and Aura MLS is greatest above the 525 K (˜21 km) isentropic surface. The global average mean bias between Aura and the Atmospheric Chemistry Experiment (ACE) for January 2005 was 2% and between Aura MLS and HALOE was 14%. The widths of the PDFs are a measure of the spatial variability and measurement precision. The Aura MLS HCl PDFs are consistently wider than those for ACE and HALOE, this reflects the retrieval uncertainties. The median observation uncertainty for Aura MLS v1.51 HCl is 12%, and the median ACE v2.2 uncertainty is 8%. We also connect Aura MLS HCl with the heritage of HALOE HCl by using neural networks to learn the interinstrument biases and provide a seamless HCl record from the launch of the Upper Atmosphere Research Satellite (UARS) in 1991 to the present.

  18. Prognosis of stage pIIIA non small cell lung cancer after mediastinal lymph node dissection or sampling.

    Science.gov (United States)

    Misthos, P; Sepsas, E; Kokotsakis, J; Skottis, I; Lioulias, A

    2009-01-01

    The aim of this study was to define the impact of systematic mediastinal lymph node dissection (MLD) and mediastinal lymph node sampling (MLS) on the long-term results of patients suffering from non-small cell lung cancer (NSCLC) with N2 disease (pIIIA/N2). From 1999 to 2002, patients with NSCLC in stage pIIIA/N2 were retrospectively classified according to MLD or MLS procedure. Several clinical and pathological factors such as overall survival, disease-free interval, and complications were recorded and analyzed. Ninety-seven (64%) patients were subjected to MLD and 54 (35%) to MLS. Comparison between the two studied groups disclosed more frequent detection of one station pN2 nodes in MLS specimens (p <0.001), while skip metastasis was more often encountered after MLD (p=0.05). Duration of the operation, amount of postoperative bleeding and incidence of prolonged air leak were not significantly different between MLD and MLS groups. Cox regression analysis of all cases disclosed squamous histology as the only favorable factor of survival. The disease-free interval was significantly longer after MLD (p <0.001). Although radical lymphadenectomy did not offer significant prolongation of survival, the disease-free interval was significantly longer after MLD compared with MLS.

  19. Antimicrobial Resistance of Staphylococcal Strains Isolated from Various Pathological Products

    Directory of Open Access Journals (Sweden)

    Laura-Mihaela SIMON

    2010-12-01

    Full Text Available Background: The optimal choice of antimicrobial therapy is an important problem in hospital environment in which the selection of resistant and virulent strains easy occurs. S. aureus and especially MRSA(methicillin-resistant S. aureus creates difficulties in both treatment and prevention of nosocomial infections. Aim: The purpose of this study is to determine the sensitivity and the resistance to chemotherapy of staphylococci strains isolated from various pathological products. Material and Method: We identified Staphylococccus species after morphological appearance, culture properties, the production of coagulase, hemolisines and the enzyme activity. The susceptibility tests were performed on Mueller-Hinton medium according to CLSI (Clinical and Laboratory Standards Institute. Results: The strains were: MSSA (methicillin-susceptible S. aureus (74%, MRSA (8%, MLS B (macrolides, lincosamides and type B streptogramines resistance (12% and MRSA and MLS B (6%. MRSA strains were more frequently isolated from sputum. MRSA associated with the MLS B strains were more frequently isolated from pus. MLS B strains were more frequently isolated from sputum and throat secretions. All S. aureus strains were susceptible to vancomycin and teicoplanin. Conclusions: All staphylococcal infections require resistance testing before treatment. MLS B shows a high prevalence among strains of S. aureus. The association between MLS B and MRSA remains a major problem in Romania.

  20. Performance analysis of a compact and low-cost mapping-grade mobile laser scanning system

    Science.gov (United States)

    Julge, Kalev; Vajakas, Toivo; Ellmann, Artu

    2017-10-01

    The performance of a low-cost, self-contained, compact, and easy to deploy mapping-grade mobile laser scanning (MLS) system, which is composed of a light detection and ranging sensor Velodyne VLP-16 and a dual antenna global navigation satellite system/inertial navigation system SBG Systems Ellipse-D, is analyzed. The field tests were carried out in car-mounted and backpack modes for surveying road engineering structures (such as roads, parking lots, underpasses, and tunnels) and coastal erosion zones, respectively. The impact of applied calculation principles on trajectory postprocessing, direct georeferencing, and the theoretical accuracy of the system is analyzed. A calibration method, based on Bound Optimization BY Quadratic Approximation, for finding the boresight angles of an MLS system is proposed. The resulting MLS point clouds are compared with high-accuracy static terrestrial laser scanning data and survey-grade MLS data from a commercially manufactured MLS system. The vertical, horizontal, and relative accuracy are assessed-the root-mean-square error (RMSE) values were determined to be 8, 15, and 3 cm, respectively. Thus, the achieved mapping-grade accuracy demonstrates that this relatively compact and inexpensive self-assembled MLS can be successfully used for surveying the geometry and deformations of terrain, buildings, road, and other engineering structures.

  1. Determinação de substitutos da manteiga de cacau em coberturas de chocolate através da análise de triacilgliceróis Determination of cocoa butter substitutes in coating chocolate.by analysis the triacylglycerol composition

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    Valéria Paula Rodrigues MINIM

    1999-05-01

    Full Text Available A legislação brasileira proíbe a adição de substitutos da manteiga de cacau ao chocolate. O presente trabalho teve como objetivo verificar o padrão de qualidade de coberturas comercializadas na região de Campinas. Para isso, foram analisadas cinco marcas de cobertura de chocolate ao leite e quatro de cobertura de chocolate amargo. Para verificar a possível adição de substitutos determinou-se, por cromatografia gasosa a alta temperatura (CGAT, a composição em triacilgliceróis da gordura extraída e os resultados foram analisados pelo método matemático de Padley & Timms. Não foi detectada a presença de substitutos da manteiga de cacau nas amostras de cobertura de chocolate analisadas.Brazilian regulations prohibit the addition of cocoa butter replacements to chocolate, in total or partial substitution. The objective of the present work was to check the quality standards of four of coating bitter Brasilian chocolate bars and five of coating milk chocolate bars, commercialized in Campinas. In order to check the possible addition of substitutes, the triacylglycerol composition was determined, and the results were analysed by Padley & Timms mathematical method. The triacylglycerol composition of each sample was determined by high temperature gas chromatography (HTGC. The presence of cocoa butter replacements was not detected in the brands of coating chocolate.

  2. Detection of inducible clindamycin resistance among Staphylococcal isolates from different clinical specimens in western India.

    Science.gov (United States)

    Pal, N; Sharma, B; Sharma, R; Vyas, L

    2010-01-01

    Macrolide (MLS B ) resistance is the most widespread and clinically important mechanism of resistance encountered with Gram-positive organisms. Resistance may be constitutive (cMLS B phenotype) or inducible (iMLS B phenotype). The iMLS B phenotypes are not differentiated by using standard susceptibility test methods, but can be distinguished by erythromycin-clindamycin disk approximation test (D-test) and demonstration of resistance genes by molecular methods. To demonstrate in vitro inducible clindamycin resistance (iMLS B ) in erythromycin-resistant (ER) and clindamycin-susceptible (CLI-S) clinical isolates of Staphylococci spp., and interpretation of susceptibility tests to guide therapy. Eight hundred and fifty-one isolates of Staphylococci spp. were recovered from various clinical specimens. All the Staphylococcal spp. were identified by conventional microbiological methods including colony morphology, Gram stain, catalase, slide coagulase and tube coagulase. Antibiotic susceptibility testing was performed by Kirby Bauer disc diffusion method. Erythromycin-resistant isolates were examined for inducible clindamycin resistance (iMLS B ) by using double disk approximation test (D-test) at 15 mm disk separation. The Staphylococci spp. isolated were 379 S. aureus [31.60% methicillin-resistant S. aureus (MRSA), 12.92% methicillin-sensitive S. aureus (MSSA)] and 472 coagulase-negative Staphylococci (CNS) [37.60% methicillin-resistant coagulase-negative Staphylococci (MRCNS), 17.86% methicillin-sensitive coagulase-negative Staphylococci (MSCNS)]. Four hundred and thirty (50.52%) Staphylococcal spp. isolates showed erythromycin resistance. Constitutive resistance was demonstrated in 202 (46.97%), inducible clindamycin resistance (iMLS B ) in 101 (23.48%), and non-inducible (MS) in 127 (29.53%). Two distinct induction phenotypes, D (18.13%) and D + (5.34%) were observed. All iMLS B isolates were susceptible to linezolid and vancomycin while 78.78% to ciprofloxacin

  3. Detection of inducible clindamycin resistance among Staphylococcal isolates from different clinical specimens in western India

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    Pal N

    2010-01-01

    Full Text Available Background: Macrolide (MLS B resistance is the most widespread and clinically important mechanism of resistance encountered with Gram-positive organisms. Resistance may be constitutive (cMLS B phenotype or inducible (iMLS B phenotype. The iMLS B phenotypes are not differentiated by using standard susceptibility test methods, but can be distinguished by erythromycin-clindamycin disk approximation test (D-test and demonstration of resistance genes by molecular methods. Aims: To demonstrate in vitro inducible clindamycin resistance (iMLS B in erythromycin-resistant (ER and clindamycin-susceptible (CLI-S clinical isolates of Staphylococci spp., and interpretation of susceptibility tests to guide therapy. Materials and Methods: Eight hundred and fifty-one isolates of Staphylococci spp. were recovered from various clinical specimens. All the Staphylococcal spp. were identified by conventional microbiological methods including colony morphology, Gram stain, catalase, slide coagulase and tube coagulase. Antibiotic susceptibility testing was performed by Kirby Bauer disc diffusion method. Erythromycin-resistant isolates were examined for inducible clindamycin resistance (iMLS B by using double disk approximation test (D-test at 15 mm disk separation. Results: The Staphylococci spp. isolated were 379 S. aureus [31.60% methicillin-resistant S. aureus (MRSA, 12.92% methicillin-sensitive S. aureus (MSSA] and 472 coagulase-negative Staphylococci (CNS [37.60% methicillin-resistant coagulase-negative Staphylococci (MRCNS, 17.86% methicillin-sensitive coagulase-negative Staphylococci (MSCNS]. Four hundred and thirty (50.52% Staphylococcal spp. isolates showed erythromycin resistance. Constitutive resistance was demonstrated in 202 (46.97%, inducible clindamycin resistance (iMLS B in 101 (23.48%, and non-inducible (MS in 127 (29.53%. Two distinct induction phenotypes, D (18.13% and D + (5.34% were observed. All iMLS B isolates were susceptible to linezolid and

  4. Molecular typing and characterization of macrolide, lincosamide and streptogramin resistance in Staphylococcus epidermidis strains isolated in a Mexican hospital.

    Science.gov (United States)

    Castro-Alarcón, Natividad; Ribas-Aparicio, Rosa María; Silva-Sánchez, Jesús; Calderón-Navarro, Amparo; Sánchez-Pérez, Alejandro; Parra-Rojas, Isela; Aparicio-Ozores, Gerardo

    2011-06-01

    Staphylococcus epidermidis is a normal commensal of skin that has become a serious clinical problem because of the combination of increased use of intravascular devices and an increasing number of hospitalized immunocompromised patients. In addition, there is a lack of information pertaining to resistance to macrolide, lincosamide and streptogramin type B (MLS(B)) in developing countries, including Mexico. The aim of this study was to investigate the incidence of resistance to MLS(B) antibiotics in isolates of S. epidermidis obtained in the General Hospital of Acapulco in Mexico. Susceptibility to erythromycin, clindamycin and quinupristin-dalfopristin was tested by a diffusion test, and MICs to oxacillin, erythromycin and lincomycin were determined. Differentiation between MLS(B) phenotypes was performed by a double disc diffusion test. A total of 38 of the 47 strains of S. epidermidis isolated from nosocomial infections were resistant to oxacillin [meticillin-resistant S. epidermidis (MRSE)]. The phenotypes obtained were: 18 constitutive MLS(B), 3 inducible MLS(B), 6 macrolide streptogramin and 4 lincosamide; 7 strains were susceptible to MLS(B) antibiotics. The genes associated with resistance were detected by PCR. Genotyping showed a predominance of the ermA gene followed by genes ermC and msrA. The frequency of the genes detected varied slightly from results that have been reported in isolates from other countries. Clonal types were identified by PFGE and revealed the dissemination of two major clones of MRSE in the Mexican hospital. This is believed to be the first report in Mexico on the genes associated with the MLS(B) resistance phenotype in S. epidermidis, in addition to observing a wide distribution of clonal types in the General Hospital of Acapulco, Mexico.

  5. Prevalence of Genotypes That Determine Resistance of Staphylococci to Macrolides and Lincosamides in Serbia.

    Science.gov (United States)

    Mišić, Milena; Čukić, Jelena; Vidanović, Dejan; Šekler, Milanko; Matić, Sanja; Vukašinović, Mihailo; Baskić, Dejan

    2017-01-01

    Macrolides, lincosamides, and streptogramins (MLS) resistance genes are responsible for resistance to these antibiotics in Staphylococcus infections. The purpose of the study was to analyze the distribution of the MLS resistance genes in community- and hospital-acquired Staphylococcus isolates. The MLS resistance phenotypes [constitutive resistance to macrolide-lincosamide-streptogramin B (cMLSb), inducible resistance to macrolide-lincosamide-streptogramin B (iMLSb), resistance to macrolide/macrolide-streptogramin B (M/MSb), and resistance to lincosamide-streptogramin A/streptogramin B (LSa/b)] were determined by double-disc diffusion method. The presence of the MLS resistance genes ( erm A, erm B, erm C, msr A/B, lnu A, lnu B, and lsa A) were determined by end-point polymerase chain reaction in 179 isolates of staphylococci collected during 1-year period at the Center for Microbiology of Public Health Institute in Vranje. The most frequent MLS phenotype among staphylococcal isolates, both community-acquired and hospital-acquired, was iMLSb (33.4%). The second most frequent was M/MSb (17.6%) with statistically significantly higher number of hospital-acquired staphylococcal isolates ( p  staphylococci (MRCNS) (90.9%) isolates with cMLSB phenotype. The msr A/B gene and M/MSb phenotype were statistically significantly higher in hospital-acquired than community-acquired staphylococci strains ( p  staphylococci harboring the rest of MLS resistance genes acquired in community and hospital settings ( p  > 0.05). The prevalence of iMLSb phenotypes may change over time, so it is necessary to perform periodic survey of MLS resistance phenotypes, particularly where the D-test is not performed routinely.

  6. A máscara laríngea supreme™ pode ser uma opção para a intubação endotraqueal em cirurgia laparoscópica?

    Directory of Open Access Journals (Sweden)

    Meltem Turkay Aydogmus

    Full Text Available Justificativa e objetivo: especialistas recomendam a intubação traqueal para o manejo das vias aéreas em procedimentos cirúrgicos laparoscópicos. A máscara laríngea (ML pode ser uma boa opção à intubação endotraqueal. Nesta série de casos, o nosso objetivo foi analisar o uso damáscara laríngea SupremeTM (MLS na prática cirúrgica laparoscópica. Métodos: o estudo foi conduzido com 60 pacientes, entre 18 e 60 anos, submetidos à cirurgia laparoscópica. Os valores de saturação periférica de O2 (SpO2 e dióxido de carbono no fim da expiração (EtCO2 foram registrados nos minutos um, 15, 30, 45 e 60. A frequência cardíaca e a pressão arterial média (PAM dos pacientes também foram registradas. Consideramos o tempo de inserção da MLS; a taxa de aplicabilidade da sonda gástrica; a ocorrência de náusea, vômito, tosse e dor de garganta uma hora após a cirurgia. Resultados: a média inicial de EtCO2 foi menor do que aos 15, 30, 45 e 60 minutos (p < 0,0001 e a média de EtCO2 aos 15 minutos foi menor do que nos outros tempos registrados. Observamos que a frequência cardíaca média inicial foi maior do que as subsequentes à inserção da MLS e as anteriores e posteriores à remoção da MLS. A frequência cardíaca média após a inserção da MLS foi acentuadamente menor do que a anterior à remoção da MLS (p = 0,013. A PAM após a inserção da MLS foi menor do que a inicial e também menor do que as anteriores à remoção da MLS (p = 0,0001. Conclusão: a MLS pode ser uma opção adequada para intubação em procedimentos cirúrgicos laparoscópicos em um grupo seleto de pacientes.

  7. Fabrication of Hadfield-Cored Multi-layer Steel Sheet by Roll-Bonding with 1.8-GPa-Strength-Grade Hot-Press-Forming Steel

    Science.gov (United States)

    Chin, Kwang-Geun; Kang, Chung-Yun; Park, Jaeyeong; Lee, Sunghak

    2018-03-01

    An austenitic Hadfield steel was roll-bonded with a 1.8-GPa-strength-grade martensitic hot-press-forming (HPF) steel to fabricate a multi-layer steel (MLS) sheet. Near the Hadfield/HPF interface, the carburized and decarburized layers were formed by the carbon diffusion from the Hadfield (1.2%C) to HPF (0.35%C) layers, and could be regarded as kinds of very thin multi-layers of 35 μm in thickness. The tensile test and fractographic data indicated that the MLS sheet was fractured abruptly within the elastic range by the intergranular fracture occurred in the carburized layer. This was because C was mainly segregated at prior austenite grain boundaries in the carburized layer, which weakened grain boundaries to induce the intergranular fracture. In order to solve the intergranular facture problem, the MLS sheet was tempered at 200 °C. The stress-strain curve of the tempered MLS sheet lay between those of the HPF and Hadfield sheets, and a rule of mixtures was roughly satisfied. Tensile properties of the MLS sheet were dramatically improved after the tempering, and the intergranular fracture was erased completely. In particular, the yield strength up to 1073 MPa along with the high strain hardening and excellent ductility of 32.4% were outstanding because the yield strength over 1 GPa was hardly achieved in conventional austenitic steels.

  8. Pumping tests in networks of multilevel sampling wells: Motivation and methodology

    Science.gov (United States)

    Butler, J.J.; McElwee, C.D.; Bohling, G.C.

    1999-01-01

    The identification of spatial variations in hydraulic conductivity (K) on a scale of relevance for transport investigations has proven to be a considerable challenge. Recently, a new field method for the estimation of interwell variations in K has been proposed. This method, hydraulic tomography, essentially consists of a series of short‐term pumping tests performed in a tomographic‐like arrangement. In order to fully realize the potential of this approach, information about lateral and vertical variations in pumping‐induced head changes (drawdown) is required with detail that has previously been unobtainable in the field. Pumping tests performed in networks of multilevel sampling (MLS) wells can provide data of the needed density if drawdown can accurately and rapidly be measured in the small‐diameter tubing used in such wells. Field and laboratory experiments show that accurate transient drawdown data can be obtained in the small‐diameter MLS tubing either directly with miniature fiber‐optic pressure sensors or indirectly using air‐pressure transducers. As with data from many types of hydraulic tests, the quality of drawdown measurements from MLS tubing is quite dependent on the effectiveness of well development activities. Since MLS ports of the standard design are prone to clogging and are difficult to develop, alternate designs are necessary to ensure accurate drawdown measurements. Initial field experiments indicate that drawdown measurements obtained from pumping tests performed in MLS networks have considerable potential for providing valuable information about spatial variations in hydraulic conductivity.

  9. Using Microwave Limb Sounder Data to Validate Model Ice Fields

    Science.gov (United States)

    Waliser, Duane E.; Li, Jui-Lin; Jiang, Jonathan H.; Tompkins, Adrian; Chern, J.-D.; Tao, W.-K.; Khairoutdinov, M.

    2006-01-01

    MLS IWC overall tends to be higher relative to ECMWF after considering MLS track sampling and sensitivity (cutoff application). Disagreement tends to be accentuated over Indian and Western Pacific Oceans and over tropical landmasses. Large disagreement occur at upper level at 147 hPa but small at lower levels at 215 and 316 hPa suggesting the need to investigate the strength of model large-scale circulation and physics associated with the IWC formation. Future work includes: Present MMF/ECMWF Comparisons at AGU/Baltimore Session on MMF/Cloud Resolving Modeling, GMAO/GSFC & at the WPac/Bejing/AGU in Tao's Cloud-Radiation Session. Write-up Results on ECMWF/MLS Comparisons for GRL. Continue with MLS vs ECMWF Water Vapor & Temperature comparisons - will seek more interaction with other MLS colleagues. Investigate the Development of Biases in ECMWF Forecasts - i.e. in the actual model. Work with GMAO-5 development team regarding their cloud microphysics performance. Integrate CloudSat into IWC Analyses.

  10. Involvement of Macrophages in the Pathogenesis of Familial Amyloid Polyneuropathy and Efficacy of Human iPS Cell-Derived Macrophages in Its Treatment.

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    Genki Suenaga

    Full Text Available We hypothesized that tissue-resident macrophages in familial amyloid polyneuropathy (FAP patients will exhibit qualitative or quantitative abnormalities, that may accelerate transthyretin (TTR-derived amyloid deposition. To evaluate this, we examined the number and subset of tissue-resident macrophages in heart tissue from amyloid-deposited FAP and control patients. In both FAP and control patients, tissue-resident macrophages in heart tissue were all Iba+/CD163+/CD206+ macrophages. However, the number of macrophages was significantly decreased in FAP patients compared with control patients. Furthermore, the proportion of intracellular TTR in CD14+ monocytes was reduced in peripheral blood compared with healthy donors. Based on these results, we next examined degradation and endocytosis of TTR in human induced pluripotent stem (iPS cell-derived myeloid lineage cells (MLs, which function like macrophages. iPS-MLs express CD163 and CD206, and belong to the inhibitory macrophage category. In addition, iPS-MLs degrade both native and aggregated TTR in a cell-dependent manner in vitro. Further, iPS-MLs endocytose aggregated, and especially polymerized, TTR. These results suggest that decreased tissue-localized macrophages disrupt clearance of TTR-derived amyloid deposits, leading to progression of a pathological condition in FAP patients. To improve this situation, clinical application of pluripotent stem cell-derived MLs may be useful as an approach for FAP therapy.

  11. Low-High and High-Low Biphasic Injection Forms in Computed Tomography Examinations of the Upper Abdomen

    International Nuclear Information System (INIS)

    Marti-Bonmati, L.; Arana, E.; Tobarra, E.; Sierra, C.

    2006-01-01

    Purpose: To analyze the influence of different biphasic and monophasic injection rate protocols in abdominal computed tomography (CT). Material and Methods: A randomized, consecutive, parallel group study was designed and conducted in 60 patients studied with the same CT helical protocol. Patients were randomly distributed into three groups: (A) monophasic (120 ml at 2.5 ml/s); (B) low-high biphasic (120 ml, first 60 ml at a rate of 2 ml/s, the other 60 ml at 2.5 ml/s); and (C) high-low biphasic (120 ml, first 60 ml at a rate of 2.5 ml/s, the other 60 ml at 2 ml/s). All patients were injected with 300 mg I/ml non-ionic contrast media at a fixed delay time of 55 s. Contrast enhancement efficacy was evaluated by attenuation coefficient measurements. Results: Although non-significant, monophasic protocol enhancements were higher than biphasic protocol enhancements in all measurements except aortic bifurcation (p = 0.003). At this level, biphasic protocols obtained an increased mean enhancement from 7.6% to 2.5% compared to monophasic protocols. Conclusion: Monophasic contrast agent injection in helical CT of the upper abdomen produces a higher enhancement of parenchymal and venous structures. No significant difference was observed between low-high and high-low biphasic protocols

  12. A FEASIBILITY STUDY ON USE OF GENERIC MOBILE LASER SCANNING SYSTEM FOR DETECTING ASPHALT PAVEMENT CRACKS

    Directory of Open Access Journals (Sweden)

    X. Chen

    2016-06-01

    Full Text Available This study aims to automatically detect pavement cracks on urban roads by employing the 3D point clouds acquired by a mobile laser scanning (MLS system. Our method consists of four steps: ground point filtering, high-pass convolution, matched filtering, and noise removal. First, a voxel-based upward growing method is applied to construct Digital Terrain Model (DTM of the road surface. Then, a high-pass filter convolutes the DTM to detect local elevation changes that may embed cracking information. Next, a two-step matched filter is applied to extract crack features. Lastly, a noise removal process is conducted to refine the results. Instead of using MLS intensity, this study takes advantages of the MLS elevation information to perform automated crack detection from large-volume, mixed-density, unstructured MLS point clouds. Four types of cracks including longitudinal, transvers, random, and alligator cracks are detected. Our results demonstrated that the proposed method works well with the RIEGL VMX-450 point clouds and can detect cracks in moderate-to-severe severity (13 - 25 mm within a 200 m by 30 m urban road segment located in Kingston, Ontario, at one time. Due to the resolution capability, small cracks with slight severity remain unclear in the MLS point cloud.

  13. Medicare Local-Local Health Network partnerships in South Australia: lessons for Primary Health Networks.

    Science.gov (United States)

    Javanparast, Sara; Baum, Fran; Barton, Elsa; Freeman, Toby; Lawless, Angela; Fuller, Jeffrey; Reed, Richard L; Kidd, Michael R

    2015-09-07

    To examine the partnerships in population health planning between Medicare Locals (MLs) and Local Health Networks (LHNs) in South Australia, and the factors that facilitated or constrained collaborations, to offer lessons for LHNs and Primary Health Networks. We conducted a qualitative study using individual interviews with key informants (executive or program leader staff) from the five South Australian MLs and the five South Australian LHNs. A total of 34 interviews were conducted between March and July 2014. Significant work was undertaken by MLs in the process of population health planning and needs assessment. Participants from both MLs and LHNs described examples of collaborative work, including data sharing and synthesis, program implementation and community consultation. The focus of LHNs on acute and intermediate care, the lack of system-level strategies to support collaboration, and constant policy and structural changes leading to uncertainty in the primary health care landscape were perceived as key barriers to collaboration. The experience of MLs and their achievements in building relationships and trust with stakeholders in their regions, including LHNs, provide valuable lessons for the new Primary Health Networks in Australia.

  14. Fabrication and critical current density analysis of YBa2Cu3O7+(BaSnO3)‧/YBa2Cu3O7+(BaSnO3)″ multilayer films

    Science.gov (United States)

    Horide, Tomoya; Sakamoto, Nobuhiro; Ichinose, Ataru; Matsumoto, Kaname

    2016-08-01

    Multilayers (MLs) comprising of YBa2Cu3O7(YBCO)+BaSnO3(BSO) layers with different BSO content were fabricated, and their critical current density (J c) was measured to understand influence of ML structure on vortex pinning. Elongated and segmented nanorods were observed in the MLs, and ab-plane aligned nanoparticles appeared depending on BSO content. When BSO formed only elongated and segmented nanorods in MLs, J c exhibited a linear relationship between J c in the single layer films. On the other hand, when MLs contained ab-plane aligned nanoparticles in addition to nanorods, J c decreased with lower-J c-layer fraction more rapidly. These results suggest that J c was degraded due to easy vortex flow along the lower-J c-layers, and that the acceleration of vortex motion depended on the type of lower-J c-layers. Vortex behavior which is not observed in conventional systems such as single layer films and bulk samples is strongly expected in MLs, since fine tuning of pinning center structure is possible.

  15. Multilevel selection theory and evidence: a critique of Gardner, 2015.

    Science.gov (United States)

    Goodnight, C J

    2015-09-01

    Gardner (2015) recently developed a model of a 'Genetical Theory of Multilevel Selection, which is a thoughtfully developed, but flawed model. The model's flaws appear to be symptomatic of common misunderstandings of the multi level selection (MLS) literature and the recent quantitative genetic literature. I use Gardner's model as a guide for highlighting how the MLS literature can address the misconceptions found in his model, and the kin selection literature in general. I discuss research on the efficacy of group selection, the roll of indirect genetic effects in affecting the response to selection and the heritability of group-level traits. I also discuss why the Price multilevel partition should not be used to partition MLS, and why contextual analysis and, by association, direct fitness are appropriate for partitioning MLS. Finally, I discuss conceptual issues around questions concerning the level at which fitness is measured, the units of selection, and I present a brief outline of a model of selection in class-structured populations. I argue that the results derived from the MLS research tradition can inform kin selection research and models, and provide insights that will allow researchers to avoid conceptual flaws such as those seen in the Gardner model. © 2015 European Society For Evolutionary Biology.

  16. Irradiation Effect of Argon Ion on Interfacial Structure Fe(2nm/Si(tsi=0.5-2 nm Multilayer thin Film

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    S. Purwanto

    2010-04-01

    Full Text Available Investigation includes formation of interfacial structure of Fe(2nm/Si(tSi= 0.5-2 nm multilayer thin film and the behavior of antiferromagnetic coupling between Fe layers due to Argon ion irradiation was investigated. [Fe(2nm/Si]30 multilayers (MLs with a thickness of Si spacer 0.5 - 2 nanometer were prepared on n-type (100 Si substrate by the helicon plasma sputtering method. Irradiation were performed using 400keV Ar ion to investigate the behavior of magnetic properties of the Fe/Si MLs. The magnetization measurements of Fe/Si MLs after 400keV Ar ion irradiation show the degradation of antiferromagnetic behavior of Fe layers depend on the ion doses. The Magnetoresistance (MR measurements using by Four Point Probe (FPP method also confirm that MR ratio decrease after ion irradiation. X-ray diffraction (XRD patterns indicate that the intensity of a satellite peak induced by a superlattice structure does not change within the range of ion dose. These results imply that the surface of interface structures after ion irradiation become rough although the layer structures are maintained. Therefore, it is considered that the MR properties of Fe/Si MLs also are due to the metallic superlattice structures such as Fe/Cr and Co/Cu MLs.

  17. Elektrická stimulace svalových skupin ruky

    OpenAIRE

    Hrozáň, Michal

    2014-01-01

    Bakalárska práca vysvetľuje dopad elektrickej stimulácie na svalové a nervové vlákna. Popisuje priebeh stimulácie a zásady, ktoré sa pri stimulácii elektrickým prúdom uplatňujú a približuje konkrétnu stimuláciu svalu palca. Práca dáva solídny základ pre pochopenie procesov prítomných pri stimulovaní živých tkanív, ktorý je kľúčový pri realizácii stimulačného prístroja. V práci je vytvorený program v Matlabe, ktorým užívateľ komunikuje s programom mikrokontroléra ATMega328 platformy Arduino Un...

  18. Mcleod syndrome: Report of an Indian family with phenotypic heterogeneity

    Science.gov (United States)

    Chakravarty, Ambar; Bhattacharya, P.; Banerjee, D.; Mukherjee, S.

    2011-01-01

    The present report deals with the clinical phenomenology of three members (brothers) of one family with McLeod syndrome (MLS). In two, the clinical pictures were of choreiform disorders with amyotrophy, which were found to be neurogenic in origin by detailed electrophysiological study. The index case had peripheral acanthocytosis; immunohematological and molecular genetic studies confirmed diagnosis of MLS. However, one brother only had a slowly progressive motor neuron disease like picture but no abnormal movement disorder. He had peripheral acanthocytes as well. The inheritance seems to be X-linked recessive in nature. The affected family members exhibited much phenotypic heterogeneity. This appears to be the first report of MLS from India. PMID:21655208

  19. Plano museológico: questões e proposições a partir do estudo de caso do Museu Lasar Segall

    OpenAIRE

    Paulo José Nascimento Lima

    2014-01-01

    O presente trabalho tem o intento de apresentar questões e proposições na construção de planos museológicos a partir das experiências do Museu Lasar Segall (MLS). No primeiro capítulo é apresentado o histórico do MLS, enfocando seu perfil museológico (escolhas conceituais) e suas práticas de gestão, assim como um paralelo de suas experiências com o pensamento museológico contemporâneo, e ainda um breve panorama com trabalhos acadêmicos que já foram realizados tendo o MLS como objeto. No segun...

  20. Geometric validation of a mobile laser scanning system for urban applications

    Science.gov (United States)

    Guan, Haiyan; Li, Jonathan; Yu, Yongtao; Liu, Yan

    2016-03-01

    Mobile laser scanning (MLS) technologies have been actively studied and implemented over the past decade, as their application fields are rapidly expanding and extending beyond conventional topographic mapping. Trimble's MX-8, as one of the MLS systems in the current market, generates rich survey-grade laser and image data for urban surveying. The objective of this study is to evaluate whether Trimble MX-8 MLS data satisfies the accuracy requirements of urban surveying. According to the formula of geo-referencing, accuracies of navigation solution and laser scanner determines the accuracy of the collected LiDAR point clouds. Two test sites were selected to test the performance of Trimble MX-8. Those extensive tests confirm that Trimble MX-8 offers a very promising tool to survey complex urban areas.

  1. THE USE OF MOBILE LASER SCANNING DATA AND UNMANNED AERIAL VEHICLE IMAGES FOR 3D MODEL RECONSTRUCTION

    Directory of Open Access Journals (Sweden)

    L. Zhu

    2013-08-01

    Full Text Available The increasing availability in multiple data sources acquired by different sensor platforms has provided the great advantages for desired result achievement. This paper proposes the use of both mobile laser scanning (MLS data and Unmanned Aerial Vehicle (UAV images for 3D model reconstruction. Due to no available exterior orientation parameters for UAV images, the first task is to georeference these images to 3D points. In order to fast and accurate acquire 3D points which are also easy to be found the corresponding locations on UAV images, automated pole extraction from MLS was developed. After georeferencing UAV images, building roofs are acquired from those images and building walls are extracted from MLS data. The roofs and the walls are combined to achieve the complete building models.

  2. Cell Senescence in Myxoid/Round Cell Liposarcoma

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    Christina Kåbjörn Gustafsson

    2014-01-01

    Full Text Available Myxoid/round cell liposarcoma (MLS/RCLS is the second most common liposarcoma type and characterized by the fusion oncogenes FUS-DDIT3 or EWSR1-DDIT3. Previous analysis of cell cycle regulatory proteins revealed a prominent expression of G1-cyclins, cyclin dependent kinases, and their inhibitors but very few cells progressing through the G1/S boundary. Here, we extend the investigation to proteins involved in cell senescence in an immunohistochemistry based study of 17 MLS/RCLS cases. Large subpopulations of tumor cells expressed the RBL2 pocket protein and senescence associated heterochromatin 1γ and IL8 receptor β. We conclude that MLS/RCLS tissues contain major populations of senescent tumor cells and this may explain the slow growth rate of this tumor type.

  3. Environmental management systems:policy implementation and environmental effects

    OpenAIRE

    Zobel, Thomas

    2005-01-01

    Organisationers miljöarbete drivs mindre och mindre av lagkrav och mer och mer av deras övergripande strategi. För att kunna vinna marknadsfördelar, systematiskt uppfylla lagkrav och utveckla mer effektiva processer, väljer ett ökande antal organisationer att införa miljöledningssystem (MLS). Ända sedan introduktionen av miljöledningsstandarden ISO 14001 har studier utförts för att utvärdera effekterna av MLS. Med hjälp av en meta-studie har existerande data gällande miljöeffekter av MLS utvä...

  4. Role of charged impurities in thermoelectric transport in molybdenum disulfide monolayers

    Science.gov (United States)

    Patil, Sukanya B.; Sankeshwar, N. S.; Mulimani, B. G.

    2017-12-01

    A theoretical study of the electronic properties, namely, electrical conductivity (EC), electronic thermal conductivity (ETC) and thermoelectric power (TEP) in 2D MoS2 monolayers (MLs), over a wide range of temperatures (10  determining the properties of supported MLs is demonstrated for the first time. Validity of Wiedemann–Franz law and Mott formula are examined for supported and free standing MLs. Calculations are in consonance with recent experimental data on mobility and TEP of exfoliated SiO2-supported MoS2 ML samples. In the case of TEP it is found that though the diffusion contribution is dominant the inclusion of the drag component, incorporating contributions from all relevant phonon scattering mechanisms, is needed to obtain good agreement with the data.

  5. A review on the toxicity and non-target effects of macrocyclic lactones in terrestrial and aquatic environments.

    Science.gov (United States)

    Lumaret, Jean-Pierre; Errouissi, Faiek; Floate, Kevin; Römbke, Jörg; Wardhaugh, Keith

    2012-05-01

    The avermectins, milbemycins and spinosyns are collectively referred to as macrocyclic lactones (MLs) which comprise several classes of chemicals derived from cultures of soil micro-organisms. These compounds are extensively and increasingly used in veterinary medicine and agriculture. Due to their potential effects on non-target organisms, large amounts of information on their impact in the environment has been compiled in recent years, mainly caused by legal requirements related to their marketing authorization or registration. The main objective of this paper is to critically review the present knowledge about the acute and chronic ecotoxicological effects of MLs on organisms, mainly invertebrates, in the terrestrial and aquatic environment. Detailed information is presented on the mode-of-action as well as the ecotoxicity of the most important compounds representing the three groups of MLs. This information, based on more than 360 references, is mainly provided in nine tables, presenting the effects of abamectin, ivermectin, eprinomectin, doramectin, emamectin, moxidectin, and spinosad on individual species of terrestrial and aquatic invertebrates as well as plants and algae. Since dung dwelling organisms are particularly important non-targets, as they are exposed via dung from treated animals over their whole life-cycle, the information on the effects of MLs on dung communities is compiled in an additional table. The results of this review clearly demonstrate that regarding environmental impacts many macrocyclic lactones are substances of high concern particularly with larval instars of invertebrates. Recent studies have also shown that susceptibility varies with life cycle stage and impacts can be mitigated by using MLs when these stages are not present. However information on the environmental impact of the MLs is scattered across a wide range of specialised scientific journals with research focusing mainly on ivermectin and to a lesser extent on abamectin

  6. Assessing the effect of micro-lysimeters on NRWI: Do micro-lysimeters adequately represent the water input of natural soil?

    Science.gov (United States)

    Kidron, Giora J.; Kronenfeld, Rafael

    2017-05-01

    The use of micro-lysimeters (MLs) by the scientific community for the measurement of non-rainfall water input, NRWI (dew, fog, water vapor) has become more widespread. With MLs being isolated bodies, we hypothesized that changes in heat flux may affect the surface temperatures and subsequently NRWI. Measurements were conducted with MLs of various lengths (3.5, 12, 20, 30, 40, 50 cm for 2014 and 3.5, 12, 50 cm for 2015), and on the adjacent soil that served as a control (COT) using cloths attached to glass plates in Sede Boqer (Negev Desert, Israel) during the late summer and fall of 2014 and 2015. In addition, periodical temperature and moisture measurements were also conducted on additional lysimeters. Non-significant differences in NRWI characterized MLs 12-50 cm-long, which could have been therefore grouped (termed ML12/50). However, these lysimeters and especially the 3.5 cm-long ML (ML3.5) yielded substantially higher values than that of COT, with the ratio of ML12/50 to COT and the ratio of ML3.5 to COT being up to 2.4 and 5.8, respectively, implying, as was indeed found during periodic measurements, lower nocturnal temperatures and subsequently higher moisture content at 0-0.2 cm at the MLs in comparison to COT. This was also reflected in the amount of recorded mornings with effective (>0.03 mm) NRWI: 34 mornings based on the ML12/50 in comparison to only 4 when based on COT. The findings raise serious concerns regarding published data on NRWI and call for proper calibration between the amounts obtained by the MLs and the natural intact soil.

  7. An ADAMTSL2 founder mutation causes Musladin-Lueke Syndrome, a heritable disorder of beagle dogs, featuring stiff skin and joint contractures.

    Directory of Open Access Journals (Sweden)

    Hannah L Bader

    2010-09-01

    Full Text Available Musladin-Lueke Syndrome (MLS is a hereditary disorder affecting Beagle dogs that manifests with extensive fibrosis of the skin and joints. In this respect, it resembles human stiff skin syndrome and the Tight skin mouse, each of which is caused by gene defects affecting fibrillin-1, a major component of tissue microfibrils. The objective of this work was to determine the genetic basis of MLS and the molecular consequence of the identified mutation.We mapped the locus for MLS by genome-wide association to a 3.05 Mb haplotype on canine chromosome 9 (CFA9 (50.11-54.26; p(raw T; p.R221C perfectly associated with MLS (p-value=10(-12. Murine ADAMTSL2 containing the p.R221C mutation formed anomalous disulfide-bonded dimers when transiently expressed in COS-1, HEK293F and CHO cells, and was present in the medium of these cells at lower levels than wild-type ADAMTSL2 expressed in parallel.The genetic basis of MLS is a founder mutation in ADAMTSL2, previously shown to interact with latent TGF-β binding protein, which binds fibrillin-1. The molecular effect of the founder mutation on ADAMTSL2 is formation of disulfide-bonded dimers. Although caused by a distinct mutation, and having a milder phenotype than human GD, MLS nevertheless offers a new animal model for study of GD, and for prospective insights on mechanisms and pathways of skin fibrosis and joint contractures.

  8. A Review on the Toxicity and Non-Target Effects of Macrocyclic Lactones in Terrestrial and Aquatic Environments

    Science.gov (United States)

    Lumaret, Jean-Pierre; Errouissi, Faiek; Floate, Kevin; Römbke, Jörg; Wardhaugh, Keith

    2012-01-01

    The avermectins, milbemycins and spinosyns are collectively referred to as macrocyclic lactones (MLs) which comprise several classes of chemicals derived from cultures of soil micro-organisms. These compounds are extensively and increasingly used in veterinary medicine and agriculture. Due to their potential effects on non-target organisms, large amounts of information on their impact in the environment has been compiled in recent years, mainly caused by legal requirements related to their marketing authorization or registration. The main objective of this paper is to critically review the present knowledge about the acute and chronic ecotoxicological effects of MLs on organisms, mainly invertebrates, in the terrestrial and aquatic environment. Detailed information is presented on the mode-of-action as well as the ecotoxicity of the most important compounds representing the three groups of MLs. This information, based on more than 360 references, is mainly provided in nine tables, presenting the effects of abamectin, ivermectin, eprinomectin, doramectin, emamectin, moxidectin, and spinosad on individual species of terrestrial and aquatic invertebrates as well as plants and algae. Since dung dwelling organisms are particularly important non-targets, as they are exposed via dung from treated animals over their whole life-cycle, the information on the effects of MLs on dung communities is compiled in an additional table. The results of this review clearly demonstrate that regarding environmental impacts many macrocyclic lactones are substances of high concern particularly with larval instars of invertebrates. Recent studies have also shown that susceptibility varies with life cycle stage and impacts can be mitigated by using MLs when these stages are not present. However information on the environmental impact of the MLs is scattered across a wide range of specialised scientific journals with research focusing mainly on ivermectin and to a lesser extent on abamectin

  9. Recent divergences in stratospheric water vapor measurements by frost point hygrometers and the Aura Microwave Limb Sounder

    Science.gov (United States)

    Hurst, Dale F.; Read, William G.; Vömel, Holger; Selkirk, Henry B.; Rosenlof, Karen H.; Davis, Sean M.; Hall, Emrys G.; Jordan, Allen F.; Oltmans, Samuel J.

    2017-01-01

    Balloon-borne frost point hygrometers (FPs) and the Aura Microwave Limb Sounder (MLS) provide high-quality vertical profile measurements of water vapor in the upper troposphere and lower stratosphere (UTLS). A previous comparison of stratospheric water vapor measurements by FPs and MLS over three sites - Boulder, Colorado (40.0° N); Hilo, Hawaii (19.7° N); and Lauder, New Zealand (45.0° S) - from August 2004 through December 2012 not only demonstrated agreement better than 1% between 68 and 26 hPa but also exposed statistically significant biases of 2 to 10% at 83 and 100 hPa (Hurst et al., 2014). A simple linear regression analysis of the FP-MLS differences revealed no significant long-term drifts between the two instruments. Here we extend the drift comparison to mid-2015 and add two FP sites - Lindenberg, Germany (52.2° N), and San José, Costa Rica (10.0° N) - that employ FPs of different manufacture and calibration for their water vapor soundings. The extended comparison period reveals that stratospheric FP and MLS measurements over four of the five sites have diverged at rates of 0.03 to 0.07 ppmv year−1 (0.6 to 1.5% year−1) from ~2010 to mid-2015. These rates are similar in magnitude to the 30-year (1980–2010) average growth rate of stratospheric water vapor (~ 1% year−1) measured by FPs over Boulder (Hurst et al., 2011). By mid-2015, the FP–MLS differences at some sites were large enough to exceed the combined accuracy estimates of the FP and MLS measurements. PMID:28966694

  10. Detection of Macrolide, Lincosamide and Streptogramin Resistance among Methicillin Resistant Staphylococcus aureus (MRSA in Mumbai

    Directory of Open Access Journals (Sweden)

    Arunagiri Subramanian

    2015-01-01

    Full Text Available Background: The increase in incidence of Methicillin Resistant Staphyloccocus aureus (MRSA and its extraordinary potential to develop antimicrobial resistance has highlighted the need for better agents to treat such infections. This has led to a renewed interest in use of new drugs for treatment with clindamycin and quinuprsitin-dalfopristin being the preferred choice for treatment. Aim & Objectives: This study was undertaken to detect the prevalence of MacrolideLincosamide-Streptogramin (MLS resistance among clinical isolates of MRSA.Material and Methods:Two hundred and thirty clinical isolates of S. aureus were subjected to routine antibiotic susceptibility testing including cefoxitin, erythromycin and quinupristindalfopristin. Inducible resistance to clindamycin was tested by 'D' test as per Clinical and Laboratory Standards Institute (CLSI guidelines. Results: Out of all S. aureus isolates, 93.91% were identified as MRSA. In the disc diffusion testing, 81.5% of isolates showed erythromycin resistance. Among these, the prevalence of constitutive (cMLS , inducible (iMLS b b and MS-phenotype were 35.80%, 31.82% and 32.39% respectively by the D-test method. 77.8% of isolates were resistant to quinupristin-dalfopristin and the Minimum Inhibitory Concentration (MIC ranged from 4–32 µg/ml. 89.20% of isolates were resistant to both quinupristin-dalfopristin and erythromycin of which 35.03%, 35.67% and 29.30% belonged to iMLS , cMLS and MS phenotype respectively. Conclusion: The emergence of quinupristindalfopristin resistance and MLS phenotypes brings b about the need for the simple and reliable D-test in routine diagnosis and further susceptibility testing for proper antimicrobial therapy.

  11. Chromium uptake from aqueous effluents by immobilized Baker's yeast Utilização de leveduras de panificação na remoção de cromo em meio aquoso

    Directory of Open Access Journals (Sweden)

    Lucia Beckmann C. Menezes

    1998-10-01

    Full Text Available Baker’s yeast immobilized in alginate was used to take up chromium from effluents. Chromium in aqueous solutions were used in different concentrations. To evaluate the viability and efficiency the baker’s yeast for chromium uptake from effluents three experiments done in two differents reactor systems: first in system 1 at 17.5 ml/s and with 10, 20, 25 and 30 mg/l Cr; second in system 2 at 38.7 ml/s with 20 mg/l Cr; third in system 2.1 at 6.65 ml/s and with 20, 30 and 40 mg/l Cr. The efficiency of chromium uptake varied between 86 and 100 %.Leveduras de panificação imobilizadas em alginato, foram utilizadas com o objetivo de promover a remoção de cromo presente em efluentes. Trabalhou-se com soluções de cromo de diferentes concentrações. A fim de avaliar a viabilidade e eficiência do uso de leveduras de panificação na remoção de cromo, três experimentos foram realizados em dois diferentes sistemas de reatores: o primeiro no sistema 1 com 17,5 ml/s e 10, 20, 25 e 30 mg/l Cr; o segundo no sistema 2 com 38,7 ml/s e 20 mg/l Cr; o terceiro no sistema 2.1 com 6,65 ml/s e 20, 30 e 40 mg/l Cr. A média das eficiências de retenção do cromo variaram entre 86 e 100%.

  12. Mycolactone gene expression is controlled by strong SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer.

    Directory of Open Access Journals (Sweden)

    Nicholas J Tobias

    Full Text Available Mycolactone A/B is a lipophilic macrocyclic polyketide that is the primary virulence factor produced by Mycobacterium ulcerans, a human pathogen and the causative agent of Buruli ulcer. In M. ulcerans strain Agy99 the mycolactone polyketide synthase (PKS locus spans a 120 kb region of a 174 kb megaplasmid. Here we have identified promoter regions of this PKS locus using GFP reporter assays, in silico analysis, primer extension, and site-directed mutagenesis. Transcription of the large PKS genes mlsA1 (51 kb, mlsA2 (7 kb and mlsB (42 kb is driven by a novel and powerful SigA-like promoter sequence situated 533 bp upstream of both the mlsA1 and mlsB initiation codons, which is also functional in Escherichia coli, Mycobacterium smegmatis and Mycobacterium marinum. Promoter regions were also identified upstream of the putative mycolactone accessory genes mup045 and mup053. We transformed M. ulcerans with a GFP-reporter plasmid under the control of the mls promoter to produce a highly green-fluorescent bacterium. The strain remained virulent, producing both GFP and mycolactone and causing ulcerative disease in mice. Mosquitoes have been proposed as a potential vector of M. ulcerans so we utilized M. ulcerans-GFP in microcosm feeding experiments with captured mosquito larvae. M. ulcerans-GFP accumulated within the mouth and midgut of the insect over four instars, whereas the closely related, non-mycolactone-producing species M. marinum harbouring the same GFP reporter system did not. This is the first report to identify M. ulcerans toxin gene promoters, and we have used our findings to develop M. ulcerans-GFP, a strain in which fluorescence and toxin gene expression are linked, thus providing a tool for studying Buruli ulcer pathogenesis and potential transmission to humans.

  13. Cadaver embalming fluid for surgical training courses: modified Larssen solution.

    Science.gov (United States)

    Bilge, Okan; Celik, Servet

    2017-11-01

    10% Formalin (F10)-fixed cadavers have disadvantages such as disturbing smell, mucosal irritation, discoloration and rigidity. We aimed to determine a suitable, simple and cost-effective embalming method that preserves color, texture, pliability and flexibility of the tissues for a long time without a disturbing smell and mucosal irritation. The embalmed cadavers were expected to be durable against environmental effects, utilizable for multiple and repetitive surgical trainings and instrumentations. Eight male (six intact, two autopsied bodies) and four female (three intact and one imported trunk) human cadavers were preserved with modified Larssen solution (MLS). Preserved bodies were kept in the deep freezers at -18/-20 °C. Bodies were allowed to thaw at room temperature 3 days prior to use. They were used in postgraduate hands-on courses for several medical disciplines. Each course lasted at least 1 day and during this period the bodies were stayed at room temperature. Assessments of 30 trainers and 252 trainees were collected during the courses. Additionally, the organoleptic characteristics of the fresh frozen (FF), preserved with MLS and F10-fixed cadavers were compared. The colors of muscles, fasciae, fatty tissue, nerves and vessels were evaluated and life-like tissues of MLS cadavers were impressive. There were no obvious or disturbing smell and sign of putrefaction of the MLS cadavers. MLS is a sustainable and relatively affordable soft cadaver embalming method. Its application is same as in other conventional methods and does not need new equipment. This article indicates the success of the MLS method in human cadavers.

  14. Ballistic Behaviour of Thick Steel Armour Plate under Oblique Impact : Experimental Investigation II

    OpenAIRE

    S. N. Dikshit

    1999-01-01

    The ballistic behaviour of thick steel armour plate at different obliquities has been investigated. Ballistic experiments were conducted in the velocity range 300-800 mls at 0°, 15°, 30° and 45° obliquity .A steel, conical projectile or 6.1 mm diameter was impacted on a 10 mm thick steel armour plate. At 30° and 45° obliquity, the plate offers protection up to a striking velocity of 800 mls. At zero obliquity, the plate provides protection below 6~ m/s. The depth of penetration decreases with...

  15. Platelet associated IgG, platelet mean life span and treatment with intravenous immunoglobulin in idiopathic thrombocytopenic purpura

    Energy Technology Data Exchange (ETDEWEB)

    Nieminen, U.; Syrjaelae, M.; Ikkala, E.; Myllylae, G.

    1988-01-01

    The clinical significance of platelet associated IgG in ITP detected by direct platelet suspension immunofluorescence test (PSIFT) was studied. The platelet mean life span (MLS) was measured with /sup 111/In-labelled platelets in 17 adult patients. All the patients had shortened platelet MLS. The direct PSIFT was positive in 14 patients. Patients were initially treated with prednisone; 12 patients with poor response to the drug were splenectomised. 8 of these 12 patients were treated with intravenous immunoglobulin (IvIg) before splenectomy. The response to IvIg was as good or better in the 3 patients with negative PSIFT, than in the 5 patients with positive PSIFT.

  16. CSF Volumetric Analysis for Quantification of Cerebral Edema After Hemispheric Infarction.

    Science.gov (United States)

    Dhar, Rajat; Yuan, Kristy; Kulik, Tobias; Chen, Yasheng; Heitsch, Laura; An, Hongyu; Ford, Andria; Lee, Jin-Moo

    2016-06-01

    Malignant cerebral edema (CED) complicates at least 20 % of large hemispheric infarcts (LHI) and may result in neurological deterioration or death. Midline shift (MLS) is a standard but crude measure of edema severity. We propose that volumetric analysis of shifts in cerebrospinal fluid (CSF) over time provides a reliable means of quantifying the spectrum of edema severity after LHI. We identified 38 patients from 2008 to 2014 with NIHSS ≥8, baseline CT <6 h after stroke onset, at least 1 follow-up (FU) CT, and no parenchymal hematoma. The volumes of CSF (sulci, ventricles, and cisterns) ipsilateral (IL) and contralateral (CL) to infarct on baseline and FU CTs were quantified by manually assisted outlining with MIPAV image analysis software, as was infarct volume and MLS on FU CTs. Percentage change in CSF volumes (∆CSF) from baseline to FU scans was correlated with MLS and compared in those with vs. without malignant edema (defined as hemicraniectomy, osmotic therapy, or death/neurological deterioration with MLS ≥5 mm). 11 of 38 subjects (29 %) developed malignant edema. Neither baseline NIHSS nor CSF volume differed between those with and without edema (median NIHSS 18 vs. 13, p = 0.12, CSF volume 102 vs. 124 ml, p = 0.16). Inter-rater reliability for CSF measurements was excellent (intraclass correlation coefficient 0.97). ∆CSF correlated strongly with MLS at peak edema (r = -0.75), even adjusting for infarct volume (p = 0.009). ∆CSF was also greater in those with malignant edema [-55 % (IQR -49 to -62) vs. -36 % (-27 to -45), p = 0.004]. ∆CSF was the greatest within IL sulci [-97 % (-86 to -99) vs. -71 % (-41 to -79), p = 0.002] but also significantly greater within CL sulci in those with malignant edema [-50 % (-29 to -65) vs. -25 % (0 to -31), p = 0.014]. More than half this CSF volume reduction occurred by the time of first FU CT around 24 h after stroke, while MLS rose later. Volumetric CSF analysis reliably quantifies

  17. Advanced Transport Operating Systems Program

    Science.gov (United States)

    White, John J.

    1990-01-01

    NASA-Langley's Advanced Transport Operating Systems Program employs a heavily instrumented, B 737-100 as its Transport Systems Research Vehicle (TRSV). The TRSV has been used during the demonstration trials of the Time Reference Scanning Beam Microwave Landing System (TRSB MLS), the '4D flight-management' concept, ATC data links, and airborne windshear sensors. The credibility obtainable from successful flight test experiments is often a critical factor in the granting of substantial commitments for commercial implementation by the FAA and industry. In the case of the TRSB MLS, flight test demonstrations were decisive to its selection as the standard landing system by the ICAO.

  18. Comparison of Global Distributions of Zonal-Mean Gravity Wave Variance Inferred from Different Satellite Instruments

    Science.gov (United States)

    Preusse, Peter; Eckermann, Stephen D.; Offermann, Dirk; Jackman, Charles H. (Technical Monitor)

    2000-01-01

    Gravity wave temperature fluctuations acquired by the CRISTA instrument are compared to previous estimates of zonal-mean gravity wave temperature variance inferred from the LIMS, MLS and GPS/MET satellite instruments during northern winter. Careful attention is paid to the range of vertical wavelengths resolved by each instrument. Good agreement between CRISTA data and previously published results from LIMS, MLS and GPS/MET are found. Key latitudinal features in these variances are consistent with previous findings from ground-based measurements and some simple models. We conclude that all four satellite instruments provide reliable global data on zonal-mean gravity wave temperature fluctuations throughout the middle atmosphere.

  19. The "Wallstent"

    DEFF Research Database (Denmark)

    Beier-Holgersen, R; Brasso, K; Nordling, J

    1993-01-01

    Ten patients have been reviewed in whom urethral stents were implanted for treatment of urethral stricture. Their urethral strictures had been treated with a median of 4.2 endoscopic urethrotomies under direct vision without success. The patients were first treated with optical urethrotomy....... One patient had a urethrotomy 12 months after insertion of the stent because of a short recurrent stricture at its distal end. The median length of follow up was 24 months. The median preoperative maximum flow rate was 6.5 ml/s, and the median postoperative maximum flow rate was 20.3 ml/s. Half...

  20. Theory for Magnetism and Triplet Superconductivity in LiFeAs

    Science.gov (United States)

    Daghofer, Maria; Brydon, Philip; Timm, Carsten; van den Brink, Jeroen

    2011-03-01

    Superconducting pnictides are widely found to feature spin-singlet pairing in the vicinity of an antiferromagnetic phase, for which nesting between electron and hole Fermi surfaces is crucial. LiFeAs differs from the other pnictides by (i) poor nesting properties and (ii) unusually shallow hole pockets. Investigating magnetic and pairing instabilities in an electronic model that incorporates these differences, we find antiferromagnetic order to be absent. Instead we observe almost ferromagnetic fluctuations which drive an instability toward spin-triplet p -wave superconductivity. P.M.R. Brydon, M. Daghofer, C. Timm, and J. van den Brink, arXiv:1009.3104 Support from the DFG under the priority program 1458 and the Emmy-Noether program.

  1. Zinc and glutamate dehydrogenase in putative glutamatergic brain structures.

    Science.gov (United States)

    Wolf, G; Schmidt, W

    1983-01-01

    A certain topographic parallelism between the distribution of histochemically (TIMM staining) identified zinc and putative glutamatergic structures in the rat brain was demonstrated. Glutamate dehydrogenase as a zinc containing protein is in consideration to be an enzyme synthesizing transmitter glutamate. In a low concentration range externally added zinc ions (10(-9) to 10(-7) M) induced an increase in the activity of glutamate dehydrogenase (GDH) originating from rat hippocampal formation, neocortex, and cerebellum up to 142.4%. With rising molarity of Zn(II) in the incubation medium, the enzyme of hippocampal formation and cerebellum showed a biphasic course of activation. Zinc ions of a concentration higher than 10(-6) M caused a strong inhibition of GDH. The effect of Zn(II) on GDH originating from spinal ganglia and liver led only to a decrease of enzyme activity. These results are discussed in connection with a functional correlation between zinc and putatively glutamatergic system.

  2. Potent immunosuppressive principles, dimeric sesquiterpene thioalkaloids, isolated from nupharis rhizoma, the rhizoma of Nuphar pumilum (nymphaeaceae): structure-requirement of nuphar-alkaloid for immunosuppressive activity.

    Science.gov (United States)

    Yamahara, J; Shimoda, H; Matsuda, H; Yoshikawa, M

    1996-09-01

    Potent immunosuppressants, the dimeric sesquiterpene thioalkaloids, 6-hydroxythiobinupharidine (2), 6,6'-dihydroxythiobinupharidine (3), 6-hydroxythionuphlutine B (5) and 6'-hydroxythionuphlutine B (6), were isolated from a natural medicine, Nupharis Rhizoma, the rhizoma of Nuphar pumilum (TIMM.) DC., through bioassay-guided separation together with five quinolizidine alkaloids (8, 9, 10, 11, 12). Dimeric sesquiterpene thioalkaloids (2, 3, 5, 6) were found to significantly inhibit anti-sheep erythrocyte plaque forming cell formation in mice spleen cells at 10(-6) M concentration. At this concentration, 2, 5 and 6 were found to exhibit no cytotoxicity to mice spleen cells, and 3 also showed only a little cytotoxicity. In addition, the inhibitory activity of several Nuphar alkaloids, dimeric sesquiterpene thioalkaloids (1, 4, 7, 8), and monomeric sesquiterpene alkaloids (9, 10, 11, 12) on anti-sheep erythrocyte plaque forming cell formation was examined and some structural requirement of Nuphar alkaloid for immunosuppressive activity was determined.

  3. Cryptococcus yokohamensis sp. nov., a basidiomycetous yeast isolated from trees and a Queensland koala kept in a Japanese zoological park.

    Science.gov (United States)

    Alshahni, Mohamed Mahdi; Makimura, Koichi; Satoh, Kazuo; Nishiyama, Yayoi; Kido, Nobuhide; Sawada, Takuo

    2011-12-01

    Three strains were isolated from the nostrils of a koala and the surrounding environment in a Japanese zoological park. Sequence analysis of the nuclear rDNA internal transcribed spacer (ITS) region and the large subunit rDNA D1/D2 domains in addition to physiological and morphological studies indicated that the isolates represent a single novel species belonging to the basidiomycetous genus Cryptococcus (Tremellales, Tremellomycetes, Agaricomycotina). Phylogenetic analysis based on D1/D2 and ITS regions revealed that the novel species belongs to the Fuciformis clade. The name Cryptococcus yokohamensis sp. nov. is proposed to accommodate these isolates with strain JCM 16989(T) (=TIMM 10001(T)=CBS 11776(T)=DSM 23671(T)) as the type strain.

  4. Ion exchange phenomena

    Energy Technology Data Exchange (ETDEWEB)

    Bourg, I.C.; Sposito, G.

    2011-05-01

    Ion exchange phenomena involve the population of readily exchangeable ions, the subset of adsorbed solutes that balance the intrinsic surface charge and can be readily replaced by major background electrolyte ions (Sposito, 2008). These phenomena have occupied a central place in soil chemistry research since Way (1850) first showed that potassium uptake by soils resulted in the release of an equal quantity of moles of charge of calcium and magnesium. Ion exchange phenomena are now routinely modeled in studies of soil formation (White et al., 2005), soil reclamation (Kopittke et al., 2006), soil fertilitization (Agbenin and Yakubu, 2006), colloidal dispersion/flocculation (Charlet and Tournassat, 2005), the mechanics of argillaceous media (Gajo and Loret, 2007), aquitard pore water chemistry (Tournassat et al., 2008), and groundwater (Timms and Hendry, 2007; McNab et al., 2009) and contaminant hydrology (Chatterjee et al., 2008; van Oploo et al., 2008; Serrano et al., 2009).

  5. Bodies at sea

    DEFF Research Database (Denmark)

    Pedersen, Michael Haldrup

    and Stage 2015) this article explores more broadly the role (and interplay) of embodied sensations in heritage communication. It does so by considering the role of sailing and rowing as a way of exploring, enacting and experiencing Viking culture and life worlds at the Viking Ship Museum, Roskilde, Denmark...... to embodiment, these have to a large extend been reserved for particular ways of sensing and performing in tourism (see call). Hence, there is still a need to develop more systematically a repertoire of vocabularies and methods directed at the various ‘affective materialities’ (Anderson and Wylie 2009) at play...... in tourism. Drawing in particular on performance based readings of heritage consumption and tourism (Haldrup and Larsen 2010; Waterton and Watson 2014; Haldrup and Bærenholdt 2015) as well as developments in non-representational theory and affect theory (Anderson and Harrison 2010; Massumi 2014; Timm Knudsen...

  6. Hematological approaches to multiple myeloma: trends from a Brazilian subset of hematologists. A cross-sectional study

    Directory of Open Access Journals (Sweden)

    Lucila Nassif Kerbauy

    Full Text Available ABSTRACT CONTEXT AND OBJECTIVE: For the last nine years, hematologists and oncologists have gathered annually at an educational symposium organized by a Brazilian and an American hospital. During the 2015 Board Review, a survey among the attendees evaluated the differences in management and treatment methods for multiple myeloma (MM. DESIGN AND SETTING: Cross-sectional study during an educational hematology symposium in São Paulo, Brazil. METHODS: Hematologists present at the symposium gave responses to an electronic survey by means of mobile phone. RESULTS: Among the 350 attendees, 217 answered the questionnaire. Most of the participants believed that immunotargeting agents (iTA might be effective for slowing MM progression in heavily pretreated patients (67% and that continued exposure to therapy might lead to emergence of resistant clones in patients with MM (76%. Most of the physicians use maintenance therapy after hematopoietic stem cell transplantation (95% and 45% of them would further restrict it to post-transplantation patients with underlying high-risk disease. The first-line drugs used for transplantation-ineligible patients (TI-MM were bortezomib-thalidomide-dexamethasone (31%, bortezomib-dexamethasone (28%, lenalidomide-dexamethasone (Rd; 17% and melphalan-based therapy (10%. Lenalidomide was the drug of choice for post-transplantation maintenance for half of the participants. No significant differences were observed regarding age or length of experience. CONCLUSION: The treatment choices for TI-MM patients were highly heterogenous and the melphalan-based regimen represented only 10% of the first-line options. Use of maintenance therapy after transplantation was a common choice. Some results from the survey were divergent from the evidence in the literature.

  7. 3-Conten corrected

    African Journals Online (AJOL)

    previously (BonDurant, 1985; Rae & Crews, 2006) to collect preputial samples. Immediately after slaughter, a sterile artificial insemination pipette attached by means of a short silicon tubing to a 20 mls syringe was inserted into the prepuce to the level of the fornix in the male. The pipette was used to scrap the prepuce back ...

  8. Evaluation of body mass index and plasma lipid profile in Boerboel ...

    African Journals Online (AJOL)

    This study evaluated the body mass index (BMI) and plasma lipid profile in Boerboel dogs. Body weights (BW), height (H) at shoulder and waist circumference (WC) were obtained from fifty-three Boerboels to determine the BMI while, body condition score (BCS) was determined subjectively. Also 5mls of blood was obtained ...

  9. Use Of EOS-AURA Observation In The MERRA-2 Reanalysis

    Science.gov (United States)

    Pawson, Steven; Wargan, Krzysztof; Coy, Lawrence L.; McCarty, Will

    2014-01-01

    Meteorological reanalyses provide multi-year gridded datasets that describe the evolution of the atmosphere. Such products use a data assimilation system, comprising of an atmospheric model, a broad suite of observations, and an analysis system that optimally combines the model forecast with the observations, using an algorithm that includes information about model and data accuracy. The mixture of observations is of central importance to the quality of the assimilated datasets. The Modern-era Retrospective Analysis for Research and Applications (MERRA) included constraints on the thermal structure of the middle atmosphere from nadir sounders on the NOAA polar-orbiting platforms (Stratospheric Sounding Units and Advanced Microwave Sounding Units). These instruments have peak sensitivities that occur well below the stratopause. As such, the radiance measurements do not provide strong constraints on stratopause temperature. The new MERRA-2 reanalysis is using EOS-MLS temperature retrievals after they are available: it will be demonstrated that these data lead to a more realistic stratopause structure in MERRA-2 than in MERRA. Similarly, the work demonstrates the improvements in lower stratospheric ozone in MERRA-2 than in MERRA, for the period when EOS-MLS ozone data are assimilated. This improvement occurs because of the ozone profile information offered by MLS in the low stratosphere, in contrast to the SBUV/2 data used for the rest of MERRA-2. The impacts of choosing to use the EOS-MLS datasets are discussed in context of the continuity of the data record in MERRA- 2.

  10. Comparative study of serum lipid levels in normotensive and pre ...

    African Journals Online (AJOL)

    Aim : This study was performed to compare the serum lipid levels of pregnant normotensive and pre-eclamptic women. Methods: It was a case control study involving 50 normotensive and 50 preeclamptic women at the University College Hospital, Ibadan, making a total of 100 participants. Their venous blood (5mls) was ...

  11. Growth Performance of Cockerels Administered Crude Follicular ...

    African Journals Online (AJOL)

    This Study was conducted to assess the performance of cockerels administered crude follicular and testicular fluids. Two hundred (200) day old Hyaline white cockerel chicks were randomly assigned to five different treatments namely control (T1), 0.5mls follicular fluid (T2), 25% testicular fluid (T3), 0.25ml follicular fluid (T4) ...

  12. In Vivo 3-D Vector Velocity Estimation with Continuous Data

    DEFF Research Database (Denmark)

    Holbek, Simon; Pihl, Michael Johannes; Ewertsen, Caroline

    2015-01-01

    In this study, a method for estimating 3-D vector velocities at very high frame rate using continuous data acquisition is presented. An emission sequence was designed to acquire real-time continuous data in one plane. The transverse oscillation (TO) method was used to estimate 3-D vector flow...... in a carotid flow phantom and in vivo in the common carotid artery of a healthy 27-year old female. Based on the out-of-plane velocity component during four periodic cycles, estimated flow rates in an experimental setup was 2.96 ml/s ± 0.35 ml/s compared to the expected 3.06 ml/s ± 0.09 ml/s. In the in vivo...... measurements, three heart cycles acquired at 2.1 kHz showed peak out-of-plane velocities of 83 cm/s, 87 cm/s and 90 cm/s in agreement with the 92 cm/s found with spectral Doppler. Mean flow rate was estimated to 257 ml/min. The results demonstrate that accurate real-time 3- D vector velocities can be obtained...

  13. AUTOMATIC GENERATION OF INDOOR NAVIGABLE SPACE USING A POINT CLOUD AND ITS SCANNER TRAJECTORY

    Directory of Open Access Journals (Sweden)

    B. R. Staats

    2017-09-01

    Full Text Available Automatic generation of indoor navigable models is mostly based on 2D floor plans. However, in many cases the floor plans are out of date. Buildings are not always built according to their blue prints, interiors might change after a few years because of modified walls and doors, and furniture may be repositioned to the user’s preferences. Therefore, new approaches for the quick recording of indoor environments should be investigated. This paper concentrates on laser scanning with a Mobile Laser Scanner (MLS device. The MLS device stores a point cloud and its trajectory. If the MLS device is operated by a human, the trajectory contains information which can be used to distinguish different surfaces. In this paper a method is presented for the identification of walkable surfaces based on the analysis of the point cloud and the trajectory of the MLS scanner. This method consists of several steps. First, the point cloud is voxelized. Second, the trajectory is analysing and projecting to acquire seed voxels. Third, these seed voxels are generated into floor regions by the use of a region growing process. By identifying dynamic objects, doors and furniture, these floor regions can be modified so that each region represents a specific navigable space inside a building as a free navigable voxel space. By combining the point cloud and its corresponding trajectory, the walkable space can be identified for any type of building even if the interior is scanned during business hours.

  14. Upper tropospheric water vapour variability over tropical latitudes ...

    Indian Academy of Sciences (India)

    It is examined whether high resolution radiosonde measurements represent well the UTWV by comparing with different satellite based (Atmospheric Infrared Sounder (AIRS), Advanced Microwave Sounding Unit-B (AMSUB) and Microwave Limb Sounder (MLS)) water vapour measurements. Very good comparison in the ...

  15. Renal dysfunction among adult patients in Mwanza, Tanzania ...

    African Journals Online (AJOL)

    60mls/min/1.73m2, a repeat creatinine test was done after 3-months to diagnose the chronic kidney disease. Results: Out of 637 patients, 48.2% were females and the median age was 45 years. Twenty-eight percent of the study population had ...

  16. Afican Health Sciences Vol 9 No 1.pmd

    African Journals Online (AJOL)

    Administrator

    needle and delivered into 15 mls of Brain-Heart Infusion broth contained in a sterile bottle. These sample broths were incubated at 37ºC for up to 7 days. After overnight incubation these broths were sub-cultured, using a sterile loop, onto Blood agar, Chocolate agar and MacConkey agar plates every day for 3 consecutive ...

  17. EAMJ April To determine.indd

    African Journals Online (AJOL)

    2009-04-04

    Apr 4, 2009 ... of renal function. Many HIV positive patients present late in our set-up. At presentation, these patients usually have weight loss with significant reduction in muscle ... of renal insufficiency (CrCI <60mls/min) as estimated by the Cockroft Gault method, with ... insufficient data on their age, gender and weight.

  18. Ficus mucoso and Senna occidentalis in rabbits.

    African Journals Online (AJOL)

    Rev Olaleye

    Nigeria Ltd. Good drinking water was provided ad libitum for the animals. Preparation of the plant extracts. The roots of ... mls of this preparation contains: Sodium cacodylatte (crystals). 2.0g. Ammonium ferric citrate. 2.0g ... graduated bottle until the desired volume was obtained. To ensure that haemorrhagic anaemia has.

  19. Sokoto Journal of Veterinary Sciences Occurrence of parasite eggs ...

    African Journals Online (AJOL)

    ADEYEYE

    water and water supplies contaminated with sewage for irrigation, post-harvest ... and washed in distilled water (1500 mls) in a plastic container. .... Pharmaceutical Biology, 3: 249-259. Beuchat LR (2002). Ecological factors influencing survival and growth of human pathogens on raw fruits and vegetables. Microbes and.

  20. Understanding Traveler Behavior : The Psychology Behind Managed Lane Use

    Science.gov (United States)

    2012-07-01

    Recent analysis of Katy Freeway/Managed Lane (ML) travelers and I-394 Freeway/High : Occupancy Toll (HOT) lane traveler data has found that many travelers pay to use these HOT : lanes and MLs when adjacent toll-free lanes are operating at nearly the ...

  1. Molecular Basis of Intrinsic Macrolide Resistance in the Mycobacterium tuberculosis Complex

    Czech Academy of Sciences Publication Activity Database

    Buriánková, Karolína; Doucet-Populaire, F.; Dorson, O.; Gondran, A.; Ghnassia, J. C.; Weiser, Jaroslav; Pernodet, J. L.

    2004-01-01

    Roč. 48, č. 1 (2004), s. 143-150 ISSN 0066-4804 R&D Projects: GA ČR GA204/00/1252 Institutional research plan: CEZ:AV0Z5020903 Keywords : ntm * mls * rrna Subject RIV: EE - Microbiology, Virology Impact factor: 4.216, year: 2004

  2. Library Science Education: A New Role for Academic Libraries

    Science.gov (United States)

    Wesley, Threasa L.

    2018-01-01

    Many individuals working in library and information organizations do not hold a master of library science (MLS) degree or other specialized library science credential. Recognizing that this professional gap could be addressed by diversified educational opportunities, the W. Frank Steely Library at Northern Kentucky University in Highland Heights…

  3. Short-Term Outcome of Multiple Port Laparoscopic Splenectomy in 10 Dogs.

    Science.gov (United States)

    Shaver, Stephanie L; Mayhew, Philipp D; Steffey, Michele A; Hunt, Geraldine B; Mayhew, Kelli N; Culp, William T N

    2015-07-01

    To describe surgical techniques for multiple port laparoscopic splenectomy (MLS) in dogs and report short-term outcome. Retrospective case series. Dogs (n = 10) with naturally occurring splenic disease. Medical records (March 2012-March 2013) of dogs that had MLS were reviewed. Data retrieved included signalment, weight, clinical signs, physical examination findings, preoperative laboratory and ultrasonographic findings, port number, size, and location, patient positioning, additional procedures performed, surgical duration, histopathologic diagnosis, duration of hospitalization, and perioperative complications. Ten dogs (median weight, 28.7 kg; range, 20.2-46.0 kg) had MLS using a 3 or 4 port technique and a vessel-sealing device for tissue dissection along the splenic hilus. Dog positioning varied because of additional laparoscopic or laparoscopic-assisted procedures including adrenalectomy (n = 2), ovariectomy (1), gastropexy (1), and intestinal resection and anastomosis (1). Conversion to an open approach was necessary in 1 dog because of inadequate visibility caused by omental adhesions. One dog had hemorrhage from an omental vessel, but open conversion was not required. MLS was associated with little perioperative morbidity and few complications in this cohort of dogs and may be a reasonable option for surgical management of dogs requiring elective splenectomy. © Copyright 2014 by The American College of Veterinary Surgeons.

  4. Information Hiding: an Annotated Bibliography

    Science.gov (United States)

    1999-04-13

    www.springer.de/catalog/html-files/deutsch/comp/3540619968. html>. [325] 063213, ‘A Multiversion Transaction Scheduler for Centralized Multilevel Se- cure...an MLS DBMS. The authors pro- pose getting around these problems by using multiversion schedulers. An abstract model is developed and shown to

  5. 424 Comparative Studies on the Larvicidal Action of Novaluron ...

    African Journals Online (AJOL)

    FIRST LADY

    2011-01-18

    Jan 18, 2011 ... to reduce synthetic pesticide usage and elimination of vectors of diseases, provides a strong impetus for ... Emphasis is on the use of botanical products, ecological controls and others such as insect growth ... 26+2oC, 80+5% r.h. The eggs were placed in transparent plastic containers containing 500mls of ...

  6. Semi-automated extraction and delineation of 3D roads of street scene from mobile laser scanning point clouds

    Science.gov (United States)

    Yang, Bisheng; Fang, Lina; Li, Jonathan

    2013-05-01

    Accurate 3D road information is important for applications such as road maintenance and virtual 3D modeling. Mobile laser scanning (MLS) is an efficient technique for capturing dense point clouds that can be used to construct detailed road models for large areas. This paper presents a method for extracting and delineating roads from large-scale MLS point clouds. The proposed method partitions MLS point clouds into a set of consecutive "scanning lines", which each consists of a road cross section. A moving window operator is used to filter out non-ground points line by line, and curb points are detected based on curb patterns. The detected curb points are tracked and refined so that they are both globally consistent and locally similar. To evaluate the validity of the proposed method, experiments were conducted using two types of street-scene point clouds captured by Optech's Lynx Mobile Mapper System. The completeness, correctness, and quality of the extracted roads are over 94.42%, 91.13%, and 91.3%, respectively, which proves the proposed method is a promising solution for extracting 3D roads from MLS point clouds.

  7. The Effect of Parenting Stress on Child Behavior Problems in High-Risk Children with Prenatal Drug Exposure

    Science.gov (United States)

    Bagner, Daniel M.; Sheinkopf, Stephen J.; Miller-Loncar, Cynthia; LaGasse, Linda L.; Lester, Barry M.; Liu, Jing; Bauer, Charles R.; Shankaran, Seetha; Bada, Henrietta; Das, Abhik

    2009-01-01

    Objective: To examine the relationship between early parenting stress and later child behavior in a high-risk sample and measure the effect of drug exposure on the relationship between parenting stress and child behavior. Methods: A subset of child-caregiver dyads (n = 607) were selected from the Maternal Lifestyle Study (MLS), which is a large…

  8. An Examination of Meaning in Life, Satisfaction with Life, Self-Concept and Locus of Control among Teachers

    Science.gov (United States)

    Tas, Ibrahim; Iskender, Murat

    2018-01-01

    The aim of this study is to examine meaning in life, satisfaction with life, self-concept and locus of control among teachers by several variables. The research group was composed of 363 teachers (114 [40%] women, 219 [60%] men) working in several districts of Istanbul. The data were collected with Meaning in Life Scale (MLS), Satisfaction with…

  9. Prevalence of HIV among people with physical disabilities in Rwanda

    African Journals Online (AJOL)

    Intervention: Blood samples were collected from the subjects who voluntarily accepted to participate in the study. Blood samples (4mls) were collected in vacutainer tubes and centrifuged to obtain serum which was analyzed using standard HIV rapid tests-determine HIV-1/2 Ab/Ag, SD-Bioline and UNI-Gold Recombigen HIV ...

  10. 14 CFR 171.323 - Fabrication and installation requirements.

    Science.gov (United States)

    2010-01-01

    ..., using applicable electric and safety codes and Federal Communications Commission (FCC) licensing... utilize solid state technology except that traveling wave tube amplifiers (TWTA) may be used. A maximum... applied, the state of the battery charge must not affect the operation of the MLS ground station. The...

  11. Maternal and perinatal outcome of patients with severe pre ...

    African Journals Online (AJOL)

    ABEOLUGBENGAS

    quatorze femmes ont reçu du. MgSO tandis ... 2006 and received Roche brand of Diazepam as infusion of 20mg in 500mls of intravenous fluid over 6 .... is prescribed at the study center in preference to Pritchard(18) and other regimens because.

  12. Moving least squares simulation of free surface flows

    DEFF Research Database (Denmark)

    Felter, C. L.; Walther, Jens Honore; Henriksen, Christian

    2014-01-01

    In this paper a Moving Least Squares method (MLS) for the simulation of 2D free surface flows is presented. The emphasis is on the governing equations, the boundary conditions, and the numerical implementation. The compressible viscous isothermal Navier–Stokes equations are taken as the starting ...

  13. Yeast contamination potential in a carbonated soft drink industry ...

    African Journals Online (AJOL)

    Components of the filling valve in a gravity filling machine namely, tulip rubber, spreader rubber and vent tube were analyzed for yeasts using the membrane filtration method. After 5 days incubation, it was found that the tulip rubber had the highest yeast count of 9 cfu/20mls while the vent tube had the least count of 5 ...

  14. Menstruation in an unusual place: A case of thoracic endometriosis ...

    African Journals Online (AJOL)

    While pelvic endometriosis is relatively common, thoracic menstruation is rare. A report of what is believed to be the first case of thoracic endometriosis in Uganda is given. A 34 year old female was complaining of on and off chest pain mainly on the right side. Clinically she had signs of pleural effusion and 500 mls of altered ...

  15. Chemical Observations of a Polar Vortex Intrusion

    Science.gov (United States)

    Schoeberl, M. R.; Kawa, S. R.; Douglass, A. R.; McGee, T. J.; Browell, E.; Waters, J.; Livesey, N.; Read, W.; Froidevaux, L.

    2006-01-01

    An intrusion of vortex edge air in D the interior of the Arctic polar vortex was observed on the January 31,2005 flight of the NASA DC-8 aircraft. This intrusion was identified as anomalously high values of ozone by the AROTAL and DIAL lidars. Our analysis shows that this intrusion formed when a blocking feature near Iceland collapsed, allowing edge air to sweep into the vortex interior. along the DC-8 flight track also shows the intrusion in both ozone and HNO3. Polar Stratospheric Clouds (PSCs) were observed by the DIAL lidar on the DC-8. The spatial variability of the PSCs can be explained using MLS HNO3 and H2O observations and meteorological analysis temperatures. We also estimate vortex denitrification using the relationship between N2O and HNO3. Reverse domain fill back trajectory calculations are used to focus on the features in the MLS data. The trajectory results improve the agreement between lidar measured ozone and MLS ozone and also improve the agreement between the HNO3 measurements PSC locations. The back trajectory calculations allow us to compute the local denitrification rate and reduction of HCl within the filament. We estimate a denitrification rate of about lO%/day after exposure to below PSC formation temperature. Analysis of Aura MLS observations made

  16. WEST AFRICAN JOURNAL OF MEDICINE

    African Journals Online (AJOL)

    Administrator

    boiling-based protocol for DNA extraction can be used for the prenatal determination of foetal haemoglobin genotype in a low resource setting. METHODS: Chorionic villi obtained from 10 women in transabdominal procedures were treated with trypsin. Prepared solution 1, (0.5gm NaOH, 250mls distilled H20 at pH. 8.0) was ...

  17. A Least Squares Collocation Method for Accuracy Improvement of Mobile LiDAR Systems

    Directory of Open Access Journals (Sweden)

    Qingzhou Mao

    2015-06-01

    Full Text Available In environments that are hostile to Global Navigation Satellites Systems (GNSS, the precision achieved by a mobile light detection and ranging (LiDAR system (MLS can deteriorate into the sub-meter or even the meter range due to errors in the positioning and orientation system (POS. This paper proposes a novel least squares collocation (LSC-based method to improve the accuracy of the MLS in these hostile environments. Through a thorough consideration of the characteristics of POS errors, the proposed LSC-based method effectively corrects these errors using LiDAR control points, thereby improving the accuracy of the MLS. This method is also applied to the calibration of misalignment between the laser scanner and the POS. Several datasets from different scenarios have been adopted in order to evaluate the effectiveness of the proposed method. The results from experiments indicate that this method would represent a significant improvement in terms of the accuracy of the MLS in environments that are essentially hostile to GNSS and is also effective regarding the calibration of misalignment.

  18. Evaluating the effect of flood damage-reducing measures: a case study of the unembanked area of Rotterdam, the Netherlands

    NARCIS (Netherlands)

    Moel, de H.; Vliet, van M.; Aerts, J.C.J.H.

    2014-01-01

    Empirical evidence of increasing flood damages and the prospect of climatic change has initiated discussions in the flood management community on how to effectively manage flood risks. In the Netherlands, the framework of multi-layer safety (MLS) has been introduced to support this risk-based

  19. 78 FR 65388 - Agency Information Collection Activities: Submission for the Office of Management and Budget (OMB...

    Science.gov (United States)

    2013-10-31

    ..., plant design, construction, training and experience, plans and procedures for the protection of public... to apply for ESPs, SDCs, COLs, or MLs. 7. An estimate of the number of annual responses: 1,050. 8. The estimated number of annual respondents: 20. 9. An estimate of the total number of hours needed...

  20. triazolo [3, 4-b

    Indian Academy of Sciences (India)

    c. kurumurthy

    Minimum bactericidal/fungicidal concentration (µg/mL). Staphyloc occus aureus. MTCC 96. Bacillus subtilis. MTCC. 121. S. aureus. MLS16. MTCC. 2940. Micrococc us luteus. MTCC. 2470. Klebsiella planticola. MTCC. 530. Escheri chia coli. MTCC. 739. Pseudom onas aerugino sa. MTCC. 2453. Candida albicans. MTCC.

  1. De novo Xp terminal deletion in a triple X female with recurrent ...

    Indian Academy of Sciences (India)

    (MLS), a rare congenital, X-linked dominant syndrome is also most commonly caused by terminal deletions of Xp. (Vergult et al. 2013). In contrast with these reports, the patient in discussion was a true 47,XXX female without any mosaic cell line, but had an Xp terminal deletion in the extra copy of the X chromosome that had ...

  2. FAA (Federal Aviation Administration) Assessment of Satellite Concepts and Aviation Spectrum Requirements.

    Science.gov (United States)

    1985-02-01

    precision approaches. MLS will provide CAT II and CAT III service. 7.2.. C yrl1fLnicat IOns CoMmUication of data will be 1cx- -plished by using the L... commuications to the far lower number of expected users in these areas (see Section 5.7). ...... . .~ . , . < 8-2 The result is a digital data requirement

  3. Fulltext PDF

    Indian Academy of Sciences (India)

    physics departments research is carried out in material science, solid state physics, spectroscopy and theoretical physics while energy research and MLS Professor units focus respectively on the solar energy devices and the nanomaterials. In many departments there is a good and healthy mixture of theory and experiment.

  4. White Paper on the Database Management System Interface Standard for Navy Next Generation Computing Resources (NGCR)

    Science.gov (United States)

    1991-07-01

    Rubix, and Teradata are under consideration for certification at the B1 level. Informix is intended to run on the HP UX 804 (HP RISC machine targeted at...Lee 3B2 and AT&T MLS. 33 Teradata has developed a database machine targeted at the B1 level. This work, a research prototype funded by NCSC, was

  5. Seroprevalence of Hepatitis C Virus (HCV) antibodies in pregnant ...

    African Journals Online (AJOL)

    Background: Hepatitis C virus (HCV) infection is a major public health concern. The aim of this study was to ascertain the seroprevalence and risk factors of HCV antibodies among pregnant women in Anyigba, Kogi State North Central Nigeria. Materials and methods:Blood samples (5mls) were collected from one hundred ...

  6. Preventive effects of lansoprazole and famotidine on gastric mucosal injury induced by low-dose aspirin in Helicobacter pylori-negative healthy volunteers.

    Science.gov (United States)

    Nishino, Masafumi; Sugimoto, Mitsushige; Kodaira, Chise; Yamade, Mihoko; Uotani, Takahiro; Shirai, Naohito; Ikuma, Mutsuhiro; Tanaka, Tatsuo; Sugimura, Haruhiko; Hishida, Akira; Furuta, Takahisa

    2011-07-01

    The preventive effects of lansoprazole and famotidine on low-dose aspirin-induced gastric mucosal injury in relation to gastric acidity were compared in healthy Japanese volunteers. Fifteen Helicobacter pylori-negative volunteers with different CYP2C19 genotypes were randomly administered aspirin 100 mg, aspirin plus famotidine 20 mg twice daily, or aspirin plus lansoprazole 15 mg once daily for 7 days each in a crossover fashion. Gastroscopy for the evaluation of mucosal injury based on modified Lanza score (MLS) and 24-hour intragastric pH monitoring were performed on day 7 of each regimen. Aspirin induced gastric mucosal injury (median MLS = 3). Lansoprazole significantly decreased MLS to 0, which was significantly lower than that by famotidine (MLS = 1) (P lansoprazole regimen were significantly higher than those with famotidine (P lansoprazole appeared to be more protective than famotidine against low-dose aspirin-induced mucosal injury but a larger well-controlled study is necessary to establish a definitive clinical benefit.

  7. 14 CFR 171.313 - Azimuth performance requirements.

    Science.gov (United States)

    2010-01-01

    ... (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Microwave Landing System (MLS) § 171..., and the beamwidth must be such that, in the installed environment, no significant lateral reflections..., in the installed environment, the CMN contributed by sidelobe reflections will not exceed the angular...

  8. Improving the Retrieval Accuracy and Long-term Consistency of Ozone Profile and Tropospheric Ozone Measurements from the OMI on EOS Aura

    Science.gov (United States)

    Liu, X.; Bak, J.; Huang, G.; Gonzalez Abad, G.; Chance, K.; Yang, K.; Nowlan, C. R.

    2017-12-01

    We have validated the Ozone Monitoring Instrument (OMI) ozone profile (PROFOZ) products from October 2004 through December 2014 retrieved by the Smithsonian Astrophysical Observatory (SAO) algorithm against ozonesonde and Microwave Limb Sounder (MLS) observations. The retrieved ozone profiles and tropospheric ozone show generally good agreement with ozonesonde and MLS observations especially in the tropics and mid-latitudes, and especially during the pre-row anomaly period (i.e., before the serious occurrence of the row anomaly in January 2009), but exhibits seasonal/latitudinal dependent biases during the entire period, a statistically significant trend with relative to ozonesonde and MLS observations and large positive biases for pressures less than 10 hPa during the post-row anomaly period. To improve the retrieval accuracy and long-term consistency of this product, we are updating our ozone profile retrieval algorithm to include the tropopause-based ozone profile climatology we have developed, recently developed cloud retrievals, updated OMI slit functions, improved solar irradiance spectra, and new meteorological data. We will improve the retrieval sensitivity to lower tropospheric ozone using longer non-O3 absorbing wavelengths to reduce the interference from surface reflectance and by improving the characterization of the OMI measurement error. We will also improve the long-term consistency of the retrievals by developing time-dependent soft calibration. Updated retrievals will be validated against ozonesonde and MLS observations.

  9. Where We Stand

    Science.gov (United States)

    1945-08-01

    that no inteligent and undel tading cooperation from any of the ruilif;Ir ;trgem it’ Ihev b1livvcd that hc top militarl nonmatids bad Ito co ni,eptt)n...o r10mls The possibilities of direct radat navigation are -rear, - emtended by die use of sarong, readily identifiable, artificial echoes prov,,ted

  10. Associateship | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Singh, Dr Arvind Ph.D. (MLS University). Date of birth: 30 June 1983. Specialization: Ocean Biogeochemistry, Anthropogenic Impacts on Marine Nitrogen Cycling, Stable Isotopes Address: Geoscience Division, Physical Research Laboratory, Navrangpura, Ahmedabad 380 009, Gujarat Contact: Office: (079) 2631 4366

  11. Differential flow rate of commercially available triamcinolone with and without preservative through small-gauge needles.

    Science.gov (United States)

    Cabrera, Mariana; Gonzalez, Alex; Albini, Thomas A; Rowaan, Cornelis; Aguilar, Mariela; Lee, William; Fortun, Jorge A; Moshfeghi, Andrew A; Flynn, Harry W; Parel, Jean-Marie A

    2014-01-01

    To compare the flow rate through different gauge needles of triamcinolone acetonide with benzyl alcohol (TABA) versus preservative-free triamcinolone acetonide injectable suspension (TAIS). Experimental injections of 1 mL of TABA or TAIS were performed through a 27-, 30-, or 32-gauge needle. A piezoelectric pressure transducer connected to a personal computer was placed between the syringe and needle to record the force-time relationship and assess the flow rate (mL/s). Measurements were performed in triplicate. Flow rates were similar between preparations using a 27-gauge needle. Using a 30-gauge needle, the flow rate was 0.058 mL/s for TABA and 0.178 mL/s for TAIS. Using a 32-gauge needle, no flow was sustained by TABA, whereas the flow rate of TAIS was 0.114 mL/s (P gauge needle without the risk of obstruction. Occlusions were seen with TABA using the 30- and 32-gauge needles. Copyright 2014, SLACK Incorporated.

  12. Fine-scale mapping of type I allergy candidate loci suggests central susceptibility genes on chromosomes 3q, 4q and Xp

    DEFF Research Database (Denmark)

    Haagerup, A; Børglum, A D; Binderup, H G

    2004-01-01

    . We analysed 97 polymorphic markers in 424 individuals from 100 sib-pair families and evaluated the data for five phenotypes: Allergic asthma, atopic dermatitis, allergic rhinitis and total and specific immunoglobulin E. RESULTS: The highest maximum likelihood scores (MLS) were obtained on chromosomes...

  13. Automatic Extraction of Road Markings from Mobile Laser Scanning Data

    Science.gov (United States)

    Ma, H.; Pei, Z.; Wei, Z.; Zhong, R.

    2017-09-01

    Road markings as critical feature in high-defination maps, which are Advanced Driver Assistance System (ADAS) and self-driving technology required, have important functions in providing guidance and information to moving cars. Mobile laser scanning (MLS) system is an effective way to obtain the 3D information of the road surface, including road markings, at highway speeds and at less than traditional survey costs. This paper presents a novel method to automatically extract road markings from MLS point clouds. Ground points are first filtered from raw input point clouds using neighborhood elevation consistency method. The basic assumption of the method is that the road surface is smooth. Points with small elevation-difference between neighborhood are considered to be ground points. Then ground points are partitioned into a set of profiles according to trajectory data. The intensity histogram of points in each profile is generated to find intensity jumps in certain threshold which inversely to laser distance. The separated points are used as seed points to region grow based on intensity so as to obtain road mark of integrity. We use the point cloud template-matching method to refine the road marking candidates via removing the noise clusters with low correlation coefficient. During experiment with a MLS point set of about 2 kilometres in a city center, our method provides a promising solution to the road markings extraction from MLS data.

  14. EVALUATION OF GROWTH OF SOME FUNGI IN CRUDE OIL ...

    African Journals Online (AJOL)

    The two species of Aspergillus A. niger and flavus used in the study appreciably tolerated the oil though the growth of A. flavus was retarded as the concentration of oil increased. Botrytis cinerea, Curvularia lunata and Colletotrichum sp. could not grow beyond the concentration of 1ml/10mls of oil Potato Dextrose Dextrose ...

  15. Spatial Visualization as Mediating between Mathematics Learning Strategy and Mathematics Achievement among 8th Grade Students

    Science.gov (United States)

    Rabab'h, Belal; Veloo, Arsaythamby

    2015-01-01

    Jordanian 8th grade students revealed low achievement in mathematics through four periods (1999, 2003, 2007 & 2011) of Trends in International Mathematics and Science Study (TIMSS). This study aimed to determine whether spatial visualization mediates the affect of Mathematics Learning Strategies (MLS) factors namely mathematics attitude,…

  16. Design and test of a novel magnetic lead screw for active suspension system in a vehicle

    DEFF Research Database (Denmark)

    Berg, Nick Ilsø; Holm, Rasmus Koldborg; Rasmussen, Peter Omand

    2014-01-01

    . Furthermore the Magnetic Lead Screw is introduced and its benefits when used with an active suspension system are discussed. Based on a model of a quarter car, the design specifications for the MLS active suspension system are found, which leads to a design study. The design study investigates the relation...

  17. a case report

    African Journals Online (AJOL)

    2015-03-26

    Mar 26, 2015 ... National Hospital Abuja. Nigeria. Email: drauduli@yahoo. ... hospital. The baby was therefore not formally referred to our hospital. On examination, she was lethargic, pale, mildly jaun- diced with a temperature of 36.8.C and SPO2 of 98%. Weight on ... evacuation of 50mls of blood. The subdural drain was.

  18. triazolo [3, 4-b

    Indian Academy of Sciences (India)

    c. kurumurthy

    Table 1. Antimicrobial activity of the synthesized compounds. Table 2. Minimum bactericidal concentration (MBC) of synthesized compounds. Test compounds. Minimum bactericidal/fungicidal concentration (µg/mL). Staphyloc occus aureus. MTCC 96. Bacillus subtilis. MTCC. 121. S. aureus. MLS16. MTCC. 2940. Micrococc.

  19. Haematological and histopathological effects of Cassava Mill ...

    African Journals Online (AJOL)

    None survived (100%mortality) in the group that was injected with 15mls CWW. Haematological changes in groups A, B and C includes: Anaemia marked by significantly low (at p< 0.05) PCV, Hb and RBC (in B and C alone). MCV values were significantly low in all the experimental groups relative to the control; MCH value ...

  20. La variacion de /s/ en Valdivia: sexo y edad.

    Science.gov (United States)

    Smith, Karen L.

    1990-01-01

    Describes the study of the use of /s/ vs. /h/ or O (in Spanish) in Valdivia, Chile, by speakers who differed in sex and age. No marked differences in relation to sex and age were found, indicating a relatively homogeneous community. (MLS)

  1. Mobile phone technology identifies and recruits trained citizens to perform CPR on out-of-hospital cardiac arrest victims prior to ambulance arrival.

    Science.gov (United States)

    Ringh, Mattias; Fredman, David; Nordberg, Per; Stark, Tomas; Hollenberg, Jacob

    2011-12-01

    In a two-parted study, evaluate a new concept were mobile phone technology is used to dispatch lay responders to nearby out-of-hospital cardiac arrests (OHCAs). Mobile phone positioning systems (MPS) can geographically locate selected mobile phone users at any given moment. A mobile phone service using MPS was developed and named Mobile Life Saver (MLS). Simulation study: 25 volunteers named mobile responders (MRs) were connected to MLS. Ambulance time intervals from 22 consecutive OHCAs in 2005 were used as controls. The MRs randomly moved in Stockholm city centre and were dispatched to simulated OHCAs (identical to controls) if they were within a 350 m distance. Real life study: during 25 weeks 1271-1801 MRs trained in CPR were connected to MLS. MLS was activated at the dispatch centre in parallel with ambulance dispatch when an OHCA was suspected. The MRs were dispatched if they were within 500 m from the suspected OHCA. Simulation study: mean response time for the MRs compared to historical ambulance time intervals was reduced by 2 min 20s (44%), pMobile phone technology can be used to identify and recruit nearby CPR-trained citizens to OHCAs for bystander CPR prior to ambulance arrival. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  2. The impact of gear regulation changes on discard rates: the case of the Baltic Sea cod fishery

    DEFF Research Database (Denmark)

    Feekings, Jordan P.; Madsen, Niels; Lewy, Peter

    2012-01-01

    in minimum landing size (MLS) have had any marked effect on the discard rates of the target species, cod. Results show that the gear regulation changes enforced in the Baltic demersal trawl fishery have had diverse effects on discard rates and are largely dependent on the gear, recruitment, and compliance...

  3. Semen Characteristics and Haematological Parmeters of West ...

    African Journals Online (AJOL)

    The effect of Cnidoscolus aconitifolius extract was carried out on eight West African Dwarf breeding Bucks weighing between 13kg-15kg and aged 18-24 months. The experiment spanned through 14 weeks. The animals were divided into two groups (T1 and T2) of four bucks each. 5mls of 20% and 30% Chaya leaf extract ...

  4. A comparison of DNA extraction procedures for the detection of Mycobacterium ulcerans, the causative agent of Buruli ulcer, in clinical and environmental specimens

    DEFF Research Database (Denmark)

    Durnez, Lies; Stragier, Pieter; Roebben, Karen

    2008-01-01

    a significantly lower DL than the OT and FP. For the different PCR targets, IS2404 showed a significantly lower DL than mlsA, MIRU1, MIRU5 and VNTR6. The FP and M16 were considerably faster than the MB and OT, while the purity of the DNA extracted with the MB was significantly higher than the DNA extracted...

  5. Facets and Challenges of Managing the Development of a $1 Billion Satellite

    Science.gov (United States)

    Loiacono, John

    2003-01-01

    Contents include the folloving: Presidents budget. Office of Administrator chart. Aura project organization chart. Agreements. Aura observatory configuration. Aura science questions. EOS Aura atmospheric profile measurements. Science objectives: tracking ozone layer recovery; global measurements of air quality; impact of atmospheric constituente on climate. MLS instruments, OH measurement example. Osone monitoring instrument (OMI). OMI technology. OMI will track global ozone changes.

  6. The Manufacture of Silver Azide R.D. 1336

    Science.gov (United States)

    1950-02-01

    vapour; this product was less sensitive than mercury fulminate . Rccommfnd-tions were (1) pcrformance and stibility tri-is to be c-rried out, (2) the... mercury to rumov( thc cont-min ted mthyl’tfd spirit. Rcp,-t wshing with further 500 mls. meths. /17. -10 - 17. Remove the drying pot to the drying

  7. Hysterosalpingography: Still relevant in the evaluation of infertility in ...

    African Journals Online (AJOL)

    MJP

    2015-04-18

    Apr 18, 2015 ... Water-soluble contrast media was introduced using a cannula placed in the cervical canal under aseptic conditions.[6,7]. Films were taken with the patient in the supine supine position, antero-posterior projection and oblique views were done when necessary. 15mls of contrast medium were administered ...

  8. Upper tropospheric water vapour variability over tropical latitudes ...

    Indian Academy of Sciences (India)

    nature of variations of UTWV is observed between radiosonde data and satellite data, except over. Singapore particularly with AIRS and MLS data, on long-term basis. An attempt is also made to examine the source for UTWV. A close relationship is found between UTWV and deep convection over Gadanki indicating that ...

  9. Anaesthetic Challenges In An Untreated Grave's Disease Parturient ...

    African Journals Online (AJOL)

    Method: Following a 500mls preload with normal saline, patient received 10mg of plain bupivacaine in the lateral position. Continuous monitoring of blood pressure, pulse rate, ECG, temperature, oxygen saturation was carried out throughout the procedure and into the post-operative period.Hypno-sedation was applied as ...

  10. Determination of phosphorus requirements of Cowpea ( Vigna ...

    African Journals Online (AJOL)

    This study was conducted to determine the phosphorus requirement of cowpea in two locations in southeastern Nigeria (Bende and Umudike) using sorption isotherm. The method used involved equilibrating 3g of soil in 30mls of 0.01m CaCl2 containing various levels of phosphorus at room temperature for 5 days.

  11. Reducing the recruitment of sedimented algae and nutrient release into the overlying water using modified soil/sand flocculation-capping in eutrophic lakes

    NARCIS (Netherlands)

    Pan, G.; Dai, L.; Li, L.; He, L.; Li, H.; Bi, L.; Gulati, R.D.

    2012-01-01

    The effect of simultaneously removing algal blooms from water and reducing the resuspension and nutrient release from the sediment was studied using modified local soil/sand flocculation-capping (MLS-capping) in simulated water-sediment systems. Twenty one sediment cores in situ with overlying water

  12. 75 FR 10206 - Codex Alimentarius Commission: Meeting of the Codex Committee on Contaminants in Food

    Science.gov (United States)

    2010-03-05

    ... Alimentarius Commission: Meeting of the Codex Committee on Contaminants in Food AGENCY: Office of Food Safety... States (U.S.) positions that will be discussed at the 4th Session of the Codex Committee on Contaminants... used in trade. The CCCF establishes and endorses permitted maximum levels (MLs) for contaminants and...

  13. Synthesis and biological evaluation of 3,6-dialkylsubstituted-[1,2,4 ...

    Indian Academy of Sciences (India)

    VIJAYENDAR VENEPALLY

    2018-02-16

    Feb 16, 2018 ... ing Micrococcus luteus MTCC 2470, Staphylococcus aureus. MTCC 96, Staphylococcus aureus MLS-16 MTCC 2940,. Bacillus subtilis MTCC 121, Escherichia coli MTCC 739,. Pseudomonas aeruginosa MTCC 2453, Klebsiella planti- cola MTCC 530 and for fungicidal activity different Candida strains were ...

  14. Modeling of a compliant joint in a Magnetic Levitation System for an endoscopic camera

    NARCIS (Netherlands)

    Simi, M.; Tolou, N.; Valdastri, P.; Herder, J.L.; Menciassi, A.; Dario, P.

    2012-01-01

    A novel compliant Magnetic Levitation System (MLS) for a wired miniature surgical camera robot was designed, modeled and fabricated. The robot is composed of two main parts, head and tail, linked by a compliant beam. The tail module embeds two magnets for anchoring and manual rough translation. The

  15. Research Directions in Database Security IV

    Science.gov (United States)

    1993-07-01

    in the entity-relationship model. In.C.V. Negoita and H.E. Prade , editors, Fuzzy Logic and Knowledge Engineering, pages 3-17. Verlag TUV Rheinland...2 Hoping for similar breakthroughs, computer security founder Dr. Willis Ware has called for a new MLS paradigm which will make networking and

  16. Paleosol at the Archean–Proterozoic contact in NW India revisited ...

    Indian Academy of Sciences (India)

    Author Affiliations. Manoj K Pandit1 Helga de Wall2 Narendra K Chauhan3. Department of Geology, University of Rajasthan, Jaipur 302 004, India. Institut für Geologie, Julius-Maximilians-Universitat Würzburg, Pleicherwall 1, 97070 Würzburg, Germany. Department of Geology, MLS University, Udaipur 313 001, India.

  17. Age, sex ratio, length-weight relationships and reproductive biology ...

    African Journals Online (AJOL)

    Exper Computer

    2012-02-21

    Feb 21, 2012 ... Sun et al., 2002, De Martini et al., 2007). In the. Mediterranean Sea, MLS has been restricted at 90 cm in. Spain and 120 cm in Morocco (ICCAT, 2011a). However, minimum catch-at-size data have been reported as 51 cm for the Aegean Sea (De Metrio, 1995); 53 cm for the northern Ionian Sea (De Metrio, ...

  18. Effect of flattened surface morphology of anodized aluminum oxide templates on the magnetic properties of nanoporous Co/Pt and Co/Pd thin multilayered films

    Science.gov (United States)

    Nguyen, T. N. Anh; Fedotova, J.; Kasiuk, J.; Bayev, V.; Kupreeva, O.; Lazarouk, S.; Manh, D. H.; Vu, D. L.; Chung, S.; Åkerman, J.; Altynov, V.; Maximenko, A.

    2018-01-01

    For the first time, nanoporous Al2O3 templates with smoothed surface relief characterized by flattened interpore areas were used in the fabrication of Co/Pd and Co/Pt multilayers (MLs) with strong perpendicular magnetic anisotropy (PMA). Alternating gradient magnetometry (AGM) revealed perfectly conserved PMA in the Co/Pd and Co/Pt porous MLs (antidot arrays) with a ratio of remanent magnetization (Mr) to saturation magnetization (MS) of about 0.99, anisotropy fields (Ha) of up to 2.6 kOe, and a small deviation angle of 8° between the easy magnetization axis and the normal to the film surface. The sufficient magnetic hardening of the porous MLs with enhanced coercive field HC of up to ∼1.9 kOe for Co/Pd and ∼1.5 kOe for Co/Pt MLs, as compared to the continuous reference samples (∼1.5-2 times), is associated with the pinning of the magnetic moments on the nanopore edges. Application of the Stoner-Wohlfarth model for fitting the experimental M/MS(H) curves yielded clear evidence of the predominantly coherent rotation mechanism of magnetization reversal in the porous films.

  19. Cervical Ripening: How Long can the Foley Catheter Safely Remain ...

    African Journals Online (AJOL)

    espace extra-amniotique sous la technique aseptique, le ballon ayant été gonflé de 30-50 mls de l\\'eau stérile. Chaque patiente prenait des antibiotiques prophylactiques. Le ballon fut expulsé en 12 heures chez 22(39%) des patients.

  20. Point clouds to indoor/outdoor accessibility diagnosis

    NARCIS (Netherlands)

    Balado, J.; Díaz-Vilariño, L.; Arias, P.; Garrido, I.

    2017-01-01

    This work presents an approach to automatically detect structural floor elements such as steps or ramps in the immediate environment of buildings, elements that may affect the accessibility to buildings. The methodology is based on Mobile Laser Scanner (MLS) point cloud and trajectory

  1. 241 Comparative Effectiveness of Certain Antimicrobial Agents in ...

    African Journals Online (AJOL)

    Nekky Umera

    aseptically transferred into 19mls of nutrient agar and then poured into sterile plates. The plates were incubated at 370C for 24-28 hours. The emerging colonies were counted and recorded as the total viable count. Attempts were made using appropriate biochemical tests to carry out identifications of possible contaminants.

  2. Rapid Resuscitation with Small Volume Hypertonic Saline Solution ...

    African Journals Online (AJOL)

    Rapid Resuscitation with Small Volume Hypertonic Saline Solution for Patients in Traumatic Haemorrhagic Shock. ... The data were entered into a computer data base and analysed. Results: Forty five patients were enrolled and resuscitated with 250 mls 7.5% HSS. Among the studied patients, 88.9% recovered from shock ...

  3. Middle lobe syndrome: a review of clinicopathological features, diagnosis and treatment.

    Science.gov (United States)

    Gudbjartsson, Tomas; Gudmundsson, Gunnar

    2012-01-01

    Middle lobe syndrome (MLS) is a rare but important clinical entity that has been poorly defined in the literature. It is characterized by recurrent or chronic collapse of the middle lobe of the right lung but can also involve the lingula of the left lung. Pathophysiologically, there are two forms of MLS, namely obstructive and nonobstructive. Obstructive MLS is usually caused by endobronchial lesions or extrinsic compression of the middle lobe bronchus such as from hilar lymphadenopathy or tumors of neoplastic origin, resulting in postobstructive atelectasis and pneumonitis. In the nonobstructive type, no obstruction of the middle lobe bronchus is evident during bronchoscopy or with computerized tomography of the chest. The etiology of the nonobstructive form is not completely understood. Inefficient collateral ventilation, infection and inflammation in the middle lobe or lingula are thought to play a role, and bronchiectasis is the most common histological finding. Patients with proven endobronchial lesions or malignancy are usually offered surgical resection directly. This contrasts with nonobstructive MLS, where most patients respond to medical treatment consisting of bronchodilators, mucolytics and broad-spectrum antibiotics. However, some patients do not respond to conservative treatment and may suffer irreversible damage of the middle lobe or lingula, in addition to having recurrent symptoms of infection or inflammation. These selected patients can be offered surgical resection of the middle lobe or lingula, which is associated with a low mortality rate and favorable outcome. Copyright © 2012 S. Karger AG, Basel.

  4. Evaluation of Organic–PLUS Foliar Fertilizer in Combination with ...

    African Journals Online (AJOL)

    Five rates of application of Organic – PLUS foliar fertilizer (0,1200, 1400, 1600 and 1800 mls ha-1) combined with 100kg ha-1 of 15-15-15 fertilizer, respectively were set up in the field using Randonmized Complete Block Design and replicated four times. The statistical results of the study indicated that the different Organic- ...

  5. Yeast Contamination Potential in a Carbonated Soft Drink Industry ...

    African Journals Online (AJOL)

    MICHAEL

    ABSTRACT: Components of the filling valve in a gravity filling machine namely, tulip rubber, spreader rubber and vent tube were analyzed for yeasts using the membrane filtration method. After 5 days incubation, it was found that the tulip rubber had the highest yeast count of 9 cfu/20mls while the vent tube had the least.

  6. Theoretical and experimental loss and efficiency studies of a magnetic lead screw

    DEFF Research Database (Denmark)

    Berg, Nick Ilsø; Holm, Rasmus Koldborg; Rasmussen, Peter Omand

    2013-01-01

    components which was not accounted for in previously results. This is done through theoretical loss calculations and various experiments. It is concluded that the linear guide is the dominating loss component in the MLS demonstrator, while the losses in the axial thrust bearing is not as dominant as expected...

  7. Theoretical and Experimental Loss and Efficiency Studies of a Magnetic Lead Screw

    DEFF Research Database (Denmark)

    Berg, Nick Ilsø; Holm, Rasmus Koldborg; Rasmussen, Peter Omand

    2015-01-01

    components that was not accounted for in previous results. This is done through theoretical loss calculations and various experiments. It is concluded that the linear guide is the dominating loss component in the MLS demonstrator, whereas the losses in the axial thrust bearing is not as dominant as expected...

  8. the role of undercutting of banks in the collapse and evolution of ...

    African Journals Online (AJOL)

    NIJOTECH

    Madubuike and Obieche. 93. A water flow rate Q = 36ml/s was applied to the rills. This flow rate was chosen as it was considered large enough to produce adequate erosion effects in the rill. Two replicates were made. The rill channel was first ponded for 10 minutes to ensure complete saturation before release of the flow.

  9. Reactive airway and anaesthesia

    African Journals Online (AJOL)

    Administrator

    the bevel facing upward. On piercing the interspinous ligament, the stylet was removed and a 20mls resistance-free glass syringe half full of air, attached to the epidural needle. A gentle continuous pressure was applied to the plunger as the needle was. *Correspondence author: Lawal I Ibrahim. Department of Anaesthesia.

  10. Interference Suppression Performance of Automotive UWB Radars Using Pseudo Random Sequences

    Directory of Open Access Journals (Sweden)

    I. Pasya

    2015-12-01

    Full Text Available Ultra wideband (UWB automotive radars have attracted attention from the viewpoint of reducing traffic accidents. The performance of automotive radars may be degraded by interference from nearby radars using the same frequency. In this study, a scenario where two cars pass each other on a road was considered. Considering the utilization of cross-polarization, the desired-to-undesired signal power ratio (DUR was found to vary approximately from -10 to 30 dB. Different pseudo random sequences were employed for spectrum spreading the different radar signals to mitigate the interference effects. This paper evaluates the interference suppression provided by maximum length sequence (MLS and Gold sequence (GS through numerical simulations of the radar’s performance in terms of probability of false alarm and probability of detection. It was found that MLS and GS yielded nearly the same performance when the DUR is -10 dB (worst case; for example when fixing the probability of false alarm to 0.0001, the probabilities of detection were 0.964 and 0.946 respectively. The GS are more advantageous than MLS due to larger number of different sequences having the same length in GS than in MLS.

  11. Comparison of long-term results of transurethral incision of the prostate with transurethral resection of the prostate, in patients with benign prostatic hypertrophy.

    Science.gov (United States)

    Tkocz, Michal; Prajsner, Andrzej

    2002-01-01

    One hundred patients with benign prostatic hypertrophy (BPH) were randomized to transurethral incision (TUIP) or transurethral resection of the prostate (TURP). The average prostate weight before operation was not more than 30.0 g. Indications for the operations were based on the disease history, physical examination, digital rectal examination, laboratory values, and pressure-flow examination. All operations were performed with patients under spinal anesthesia. TUIP was performed with a Collins knife, and TURP was performed with a resectoscope. Follow-up was performed 24 months after the operations. After treatment there were statistically significant daytime and nocturnal reduction in voiding frequencies of 2.9 and 1.7, respectively, after TUIP, and 2.0 and 1.5 after TURP. In both groups, there occurred significantly better maximal flow rate from 7.6 mL/s to 16.9 mL/s in group I and from 6.9 mL/s to 17.6 mL/s in group II. The mean values of linearized passive urethral resistance relation in both groups significantly decreased from 3.6 +/- 0.6 to 1.0 +/- 0.5 after TUIP and from 3.9 +/- 04 to 1.4 +/- 0.5 after TURP. The TUIP procedure is effective and safe for patients with a small number of complications. Copyright 2002 Wiley-Liss, Inc.

  12. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    It is examined whether high resolution radiosonde measurements represent well the UTWV by comparing with different satellite based (Atmospheric Infrared Sounder (AIRS), Advanced Microwave Sounding Unit-B (AMSUB) and Microwave Limb Sounder (MLS)) water vapour measurements. Very good comparison in the ...

  13. Total Petroleum Hydrocarbon Content (TPH) As an Index ...

    African Journals Online (AJOL)

    MICHAEL

    post-phytoremediated crude oil contaminated soil. Plant and soil analysis were carried out using the photometric method of American Petroleum Institute (API). Result has shown that Leucaena leucocephala treated soil at various. (0, 25, 50, & 100mls) levels of pollution had TPH (mg/kg) content of 75.33±38.42, ...

  14. Comparison of closed-pressurized and open-refluxed vessel ...

    African Journals Online (AJOL)

    Samples of residual fuel oil reference material (SRM 1634c) were mineralized in closed digestion vessels from Milestone Laboratory Systems (MLS) or from PAAR (HPA) or in open-refluxed microwave digestion flasks from Prolabo. The three digestion systems were evaluated in terms of accuracy and precision, reagents ...

  15. 14 CFR 171.309 - General requirements.

    Science.gov (United States)

    2010-01-01

    ..., associated monitor, remote control and indicator equipment. (c) MLS ground equipment must be designed to... service conditions: (1) AC line parameters, DC voltage, elevation and duty: 120 VAC nominal value—102 V to... centimeters (1/2 inch) radial thickness of clear ice. Antenna Radome De-Icing: Down to −6°C (20 °F) and wind...

  16. Effect of Zinc supplementation on the Management of Acute ...

    African Journals Online (AJOL)

    Each patient also had the low osmolar UNICEF-ORS at 75mls/kg. and the child's usual feeds. Weekly follow-up visits were conducted for 12 weeks after the diarrhea episode. Incidence and prevalence of diarrhea were compared between the groups. Neither the attending clinician nor the patient nor the data analyst was ...

  17. AUTOMATIC EXTRACTION OF ROAD MARKINGS FROM MOBILE LASER SCANNING DATA

    Directory of Open Access Journals (Sweden)

    H. Ma

    2017-09-01

    Full Text Available Road markings as critical feature in high-defination maps, which are Advanced Driver Assistance System (ADAS and self-driving technology required, have important functions in providing guidance and information to moving cars. Mobile laser scanning (MLS system is an effective way to obtain the 3D information of the road surface, including road markings, at highway speeds and at less than traditional survey costs. This paper presents a novel method to automatically extract road markings from MLS point clouds. Ground points are first filtered from raw input point clouds using neighborhood elevation consistency method. The basic assumption of the method is that the road surface is smooth. Points with small elevation-difference between neighborhood are considered to be ground points. Then ground points are partitioned into a set of profiles according to trajectory data. The intensity histogram of points in each profile is generated to find intensity jumps in certain threshold which inversely to laser distance. The separated points are used as seed points to region grow based on intensity so as to obtain road mark of integrity. We use the point cloud template-matching method to refine the road marking candidates via removing the noise clusters with low correlation coefficient. During experiment with a MLS point set of about 2 kilometres in a city center, our method provides a promising solution to the road markings extraction from MLS data.

  18. Highly significant linkage to chromosome 3q13.31 for rhinitis and related allergic diseases

    DEFF Research Database (Denmark)

    Brasch-Andersen, C; Haagerup, A; Borglum, AD

    2006-01-01

    or all are still inconclusive. Following genome-wide scans on multiple phenotypes, we previously suggested that chromosome 3q13.12-q21.2 harbours an allergy locus. OBJECTIVE: To identify candidate loci in the Danish population, two additional independent sets of sib-pair families were fine-scale mapped...... in candidate regions showing maximum likelihood scores (MLS) > or =1.5 in the genome-wide scans. RESULTS: Twenty eight microsatellite markers in a denser map on chromosome 3q were analysed in 236 allergy sib-pair families including 125 sib pairs with rhinitis. We report significant evidence for linkage...... to chromosome 3q13.31 for rhinitis (MLS 5.55, identity by descent (IBD) 63.9%) and atopy (increased specific immunoglobulin E) (MLS 3.71, IBD 61.7%). We obtained an MLS of 5.1 (IBD 67.3%) at 3q13.31 when sib pairs with both rhinitis and atopy were analysed. CONCLUSION: This study reports the first statistically...

  19. Njv Magazine 3 final

    African Journals Online (AJOL)

    En-Joy

    at 5 C. WBF & HCT were used prior to ice preservation and at 4, 8, 12, 24, and 36 hrs post ice preservation to observe for the presence of motile trypanosomes. A total of 8 mice, two per sample were inoculated intraperitonealy with 0.2mls of the blood samples at each time interval of preservation. The level of parasitaemia ...

  20. March 2010 Final for Publicat...

    African Journals Online (AJOL)

    User

    specimen was taken by masturbation following three days of sexual abstinence and analysed in accordance with WHO guidelines (WHO, 1999).Microscopy, culture and sensitivity were done on all specimen collected. For the purpose of this study, normospermia refers to a sperm volume of at least. 2.0mls/ejaculate; while ...

  1. Synthesis of nanocomposites using glasses and mica as templates

    Indian Academy of Sciences (India)

    Various nanocomposites were synthesized using either a silica-based glass or mica crystallites as the medium. ... DST Unit on Nano Science and MLS Professor's Unit, Indian Association for the Cultivation of Science, Kolkata 700 032, India; Department of Materials Science and Engineering, Johns Hopkins University, ...

  2. Design of a magnetic lead screw for wave energy conversion

    DEFF Research Database (Denmark)

    Holm, Rasmus Koldborg; Berg, Nick Ilsø; Rasmussen, Peter Omand

    2012-01-01

    on the bearing supports used to compensate for the magnetic attraction forces and the resulting deflection of the rotor. Also, in order to avoid some of the production related disadvantages of using surface mounted magnets, an embedded magnet topology is proposed. To demonstrate the technology a scaled 17 kN MLS...

  3. Reliability of the Motor Learning Strategy Rating Instrument for Children and Youth with Acquired Brain Injury

    Science.gov (United States)

    Kamath, Trishna; Pfeifer, Megan; Banerjee-Guenette, Priyanka; Hunter, Theresa; Ito, Julia; Salbach, Nancy M.; Wright, Virginia; Levac, Danielle

    2012-01-01

    Purpose: To evaluate reliability and feasibility of the Motor Learning Strategy Rating Instrument (MLSRI) in children with acquired brain injury (ABI). The MLSRI quantifies the extent to which motor learning strategies (MLS) are used within physiotherapy (PT) interventions. Methods: PT sessions conducted by ABI team physiotherapists with a…

  4. Urban Road Transportation in Nigeria From 1960 To 2006 ...

    African Journals Online (AJOL)

    Choice-Academy

    populated Northern Region. The roads in. Nigeria were classified into three (3) groups. Federal Roads or Trunk A – 8,800 kms (5,500mls), this represented the skeleton on which the country's road system was built. This trunk represented the main North-South arteries and five. East-West arteries. The Trunk B roads, of.

  5. The ultrastructure of bone and its relevance to mechanical properties

    Science.gov (United States)

    Schwarcz, Henry P.; Abueidda, Diab; Jasiuk, Iwona

    2017-09-01

    Bone is a biologically generated composite material comprised of two major structural components: crystals of apatite and collagen fibrils. Computational analysis of the mechanical properties of bone must make assumptions about the geometric and topological relationships between these components. Recent transmission electron microscope (TEM) studies of samples of bone prepared using ion milling methods have revealed important previously unrecognized features in the ultrastructure of bone. These studies show that most of the mineral in bone lies outside the fibrils and is organized into elongated plates 5 nanometers (nm) thick, 80 nm wide and hundreds of nm long. These so-called mineral lamellae (MLs) are mosaics of single 5 nm-thick, 20 - 50 nm wide crystals bonded at their edges. MLs occur either stacked around the 50 nm-diameter collagen fibrils, or in parallel stacks of 5 or more MLs situated between fibrils. About 20% of mineral is in gap zones within the fibrils. MLs are apparently glued together into mechanically coherent stacks which break across the stack rather than delaminating. ML stacks should behave as cohesive units during bone deformation. Finite element computations of mechanical properties of bone show that the model including such features generates greater stiffness and strength than are obtained using conventional models in which most of the mineral, in the form of isolated crystals, is situated inside collagen fibrils.

  6. Simultaneous Observations fo Polar Stratospheric Clouds and HNO3 over Scandinavia in January, 1992

    Science.gov (United States)

    Massie, S. T.; Santee, M. L.; Read, W. G.; Grainger, R. G.; Lambert, A.; Mergenthaler, J. L.; Dye, J. E.; Baumbardner, D.; Randel, W. J.; Tabazadeh, A.; hide

    1996-01-01

    Simultaneous observations of Polar Stratospheric Cloud aerosol extinction and HNO3 mixing ratios over Scandinavia are examined for January 9-10, 1992. Data measured by the Microwave Limb Sounder (MLS), Cryogenic Limb Array Etalon, Spectrometer (CLAES), and Improved Stratospheric and Mesospheric Sounder (ISAMA) experiments on the Upper Atmosphere Research Satellite (UARS) are examined at locations adjacent to parcel trajectory positions.

  7. Validation of Aura Microwave Limb Sounder O3 and CO Observations in the Upper Troposphere and Lower Stratosphere

    Science.gov (United States)

    Livesey, N. J.; Filipiak, M. J.; Froidevaux, L.; Read, W. G.; Lambert, A.; Santee, J. L.; Jiang, J. H.; Pumphrey, H. C.; Waters, J. W.; Cofield, R. E.; hide

    2008-01-01

    Global satellite observations of ozone and carbon monoxide from the Microwave Limb Sounder (MLS) on the EOS Aura spacecraft are discussed with emphasis on those observations in the 2 15 - 100 hPa region (the upper troposphere and lower stratosphere). The precision, resolution and accuracy of the data produced by the MLS "version 2.2" processing algorithms are discussed and quantified. O3 accuracy is estimated at approx.40 ppbv +5% (approx.20 ppbv +20% at 215 hPa) while the CO accuracy is estimated at approx.30 ppbv +30% for pressures of 147 hPa and less. Comparisons with expectations and other observations show good agreements for the O3 product, generally consistent with the systematic errors quoted above. In the case of COY a persistent factor of approx.2 high bias is seen at 215 hPa. However, the morphology is shown to be realistic, consistent with raw MLS radiance data, and useful for scientific study. The MLS CO data at higher altitudes are shown to be consistent with other observations.

  8. Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones

    Directory of Open Access Journals (Sweden)

    Wilson Peter

    2008-10-01

    Full Text Available Abstract Background Mycolactones are immunosuppressive and cytotoxic polyketides, comprising five naturally occurring structural variants (named A/B, C, D, E and F, produced by different species of very closely related mycobacteria including the human pathogen, Mycobacterium ulcerans. In M. ulcerans strain Agy99, mycolactone A/B is produced by three highly homologous type I polyketide megasynthases (PKS, whose genes (mlsA1: 51 kb, mlsA2: 7.2 kb and mlsB: 42 kb are found on a 174 kb plasmid, known as pMUM001. Results We report here comparative genomic analysis of pMUM001, the complete DNA sequence of a 190 kb megaplasmid (pMUM002 from Mycobacterium liflandii 128FXT and partial sequence of two additional pMUM replicons, combined with liquid chromatography-tandem mass spectrometric (LC-MS/MS analysis. These data reveal how PKS module and domain differences affecting MlsB correlate with the production of mycolactones E and F. For mycolactone E these differences from MlsB in M. ulcerans Agy99 include replacement of the AT domain of the loading module (acetate to propionate and the absence of an entire extension module. For mycolactone F there is also a reduction of one extension module but also a swap of ketoreductase domains that explains the characteristic stereochemistry of the two terminal side-chain hydroxyls, an arrangement unique to mycolactone F Conclusion The mycolactone PKS locus on pMUM002 revealed the same large, three-gene structure and extraordinary pattern of near-identical PKS domain sequence repetition as observed in pMUM001 with greater than 98.5% nucleotide identity among domains of the same function. Intra- and inter-strain comparisons suggest that the extreme sequence homogeneity seen among the mls PKS genes is caused by frequent recombination-mediated domain replacement. This work has shed light on the evolution of mycolactone biosynthesis among an unusual group of mycobacteria and highlights the potential of the mls locus to

  9. 3-D magnetotelluric imaging of the Phayao Fault Zone, Northern Thailand: Evidence for saline fluid in the source region of the 2014 Chiang Rai earthquake

    Science.gov (United States)

    Boonchaisuk, Songkhun; Noisagool, Sutthipong; Amatyakul, Puwis; Rung-Arunwan, Tawat; Vachiratienchai, Chatchai; Siripunvaraporn, Weerachai

    2017-10-01

    Seismicity in Thailand had been relatively low for decades prior to the Mw 6.5 earthquake of 5 May 2014 which came as a surprise and was followed by thousands of aftershocks. Most of the epicenters were located in the transition region between the Mae Lao Segment (MLS) and the Pan Segment (PS) of the Phayao Fault Zone (PFZ). We conducted a 3-D magnetotelluric (MT) survey (31 sites) to image the deep PFZ structure. The shallow 3-D resistivity structure matches very well with the surface geology, while the deeper structures disclose many interesting resistive and conductive anomalies. However, the most interesting feature of this study is the large conductive anomaly (ML) located at a depth of 4 km to the mid-crust beneath the MLS near the seismogenic zone. Our current hypothesis is that the ML conductor has a highly interconnected aqueous fluid content and also plays crucial role in the earthquake sequence of the 5 May 2014 event. As our previous seismic waveform study revealed that the MLS has a relatively high fault plane instability, the fluid within the fractured fault would further reduce the fault strength. The accumulated pre-existing tectonic stress from the north can therefore overcome the maximum frictional strength of the MLS, and hence cause it to slip and produce the main shock. With the local structural heterogeneities and fluid in the fractured fault zones, the aftershocks then occurred on both the PS and MLS. This is in contrast to the Mae Chan Fault Zone (MCFZ) in the north which many scientists expected to generate a larger magnitude earthquake than any other faults. Since instrumental record, it has only generated a few Mw 4 earthquakes. Some of our MT stations were located within the MCFZ. However, there is no deep conductor as the conductor lies beneath the MLS. A lack of interconnected fluid within the deep fault beneath the MCFZ might be one of the reasons for the lower seismic activity from the MCFZ. Other geophysical methods, such as seismic

  10. Inducible clindamycin and methicillin resistant Staphylococcus aureus in a tertiary care hospital, Kathmandu, Nepal.

    Science.gov (United States)

    Adhikari, R P; Shrestha, S; Barakoti, A; Amatya, R

    2017-07-11

    Staphylococcus aureus, an important nosocomial pathogen, is frequently associated with infections in human. The management of the infections by it especially methicillin resistant ones is often difficult because methicillin resistant S. aureus is usually resistant to multiple antibiotics. Macrolide-lincosamide streptogramin B family of antibiotics is commonly used to treat such infections as an alternative to vancomycin. This study was conducted over the period of one and half year from November 2013-April 2015 in Microbiology laboratory of Nepal Medical College and Teaching Hospital, Kathmandu, Nepal to find the incidence of different phenotypes of MLS B resistance among S. aureus from clinical samples and their association with methicillin resistance. Two hundred seventy isolates of S. aureus were included in the study. Methicillin resistance was detected by cefoxitin disc diffusion method and inducible clindamycin resistance by erythromycin and clindamycin disc approximation test (D-test). Of the 270 clinical isolates of S. aureus, 25.1% (68/270) were MRSA. Erythromycin and clindamycin resistance was seen in 54.4% (147/270) and 41.8% (113/270) isolates respectively. Resistance to erythromycin and clindamycin were higher in MRSA as compared to MSSA (erythromycin-resistance: 88.2% Vs 39.1% and clindamycin-resistance: 79.4% Vs 41.8%). The overall prevalence of i MLS B and c MLS B phenotype was 11.48% (31/270) and 29.25% (79/270) respectively. Both i MLS B and c MLS B phenotypes predominated in MRSA strains. Detection rate of MRSA in our study shows the necessity to improve in healthcare practices and to formulate new policy for the control of MRSA infections. Clindamycin resistance in the form of i MLS B and c MLS B especially among MRSA emphasizes the need of D-test to be performed routinely in our set up while using clindamycin as an alternative choice to anti-staphylococcal antibiotics like vancomycin and linezolid in the treatment of staphylococcal infections.

  11. Adverse events and therapeutic efficacy associated with TACE for hepatocellular carcinoma with a miriplatin-lipiodol suspension in comparison with a cisplatin-lipiodol suspension

    International Nuclear Information System (INIS)

    Araki, Takuji; Okada, Taiki; Kimura, Kazufumi; Sawada, Eiichi; Sano, Katushiro; Araki, Tsutomu

    2012-01-01

    The aim of this study was to evaluate the short-term adverse events and therapeutic efficacy of transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) with a miriplatin-lipiodol suspension in comparison with a cisplatin-lipiodol suspension. Of patients who underwent TACE for unresectable HCCs in 2009 and 2010, twenty-nine and twenty-seven patients underwent TACE using cisplatin-lipiodol suspension (C-LS) and miriplatin-lipiodol suspension (M-LS), respectively. Adverse events of fever, pain, nausea, anorexia, elevation of aspartate aminotransferase (AST), total bilirubin, creatinine and a decrease in platelet count were evaluated by the National Cancer Institute Common Toxicity Criteria Ver.4. to compare the C-LS and M-LS groups. The short-term therapeutic efficacy of both groups was evaluated by the treatment effect (TE) on the CT images three months after TACE according to the General Rules for the Clinical and Pathological Study of Primary Liver Cancer (the 5th edition, Revised Version). With regard to the adverse events, the M-LS group had significantly less fever and anorexia than the C-LS group. No critical adverse events were observed in either group. The therapeutic efficacy was not significantly different between the groups. TACE with M-LS had fewer adverse events than TACE with C-LS, but neither TACE led to any critical adverse events. The short-term therapeutic efficacy of TACE with M-LS was equivalent to that of TACE with C-LS. (author)

  12. Abundance and distribution of Macrolide-Lincosamide-Streptogramin resistance genes in an anaerobic-aerobic system treating spiramycin production wastewater.

    Science.gov (United States)

    Liu, Miaomiao; Ding, Ran; Zhang, Yu; Gao, Yingxin; Tian, Zhe; Zhang, Tong; Yang, Min

    2014-10-15

    The behaviors of the Macrolide-Lincosamide-Streptogramin (MLS) resistance genes were investigated in an anaerobic-aerobic pilot-scale system treating spiramycin (SPM) production wastewater. After screening fifteen typical MLS resistance genes with different mechanisms using conventional PCR, eight detected genes were determined by quantitative PCR, together with three mobile elements. Aerobic sludge in the pilot system exhibited a total relative abundance of MLS resistance genes (per 16S rRNA gene) 2.5 logs higher than those in control samples collected from sewage and inosine wastewater treatment systems (P resistance genes. However, the total relative gene abundance in anaerobic sludge (4.3 × 10(-1)) was lower than that in aerobic sludge (3.7 × 10(0)) despite of the higher SPM level in anaerobic reactor, showing the advantage of anaerobic treatment in reducing the production of MLS resistance genes. The rRNA methylase genes (erm(B), erm(F), erm(X)) were the most abundant in the aerobic sludge (5.3 × 10(-1)-1.7 × 10(0)), followed by esterase gene ere(A) (1.3 × 10(-1)) and phosphorylase gene mph(B) (5.7 × 10(-2)). In anaerobic sludge, erm(B), erm(F), ere(A), and msr(D) were the major ones (1.2 × 10(-2)-3.2 × 10(-1)). These MLS resistance genes (except for msr(D)) were positively correlated with Class 1 integron (r(2) = 0.74-0.93, P < 0.05), implying the significance of horizontal transfer in their proliferation. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. Multidrug-resistant oral Capnocytophaga gingivalis responsible for an acute exacerbation of chronic obstructive pulmonary disease: Case report and literature review.

    Science.gov (United States)

    Ehrmann, Elodie; Jolivet-Gougeon, Anne; Bonnaure-Mallet, Martine; Fosse, Thierry

    2016-12-01

    Capnocytophaga genus was recently known to highly contribute to the beta-lactam (BL) and macrolide-lincosamide-streptogramin (MLS) resistance gene reservoir in the oral microbiota (BL: bla CSP-1 and bla CfxA ; MLS: erm(F) and erm(C)). But fluoroquinolone (FQ) resistance remains uncommon in literature, without available data on resistance mechanisms. For the first time, a case of acute exacerbation of chronic obstructive pulmonary disease (COPD) was described in a 78-year-old immunocompetent patient due to a multidrug-resistant Capnocytophaga gingivalis isolate with significant microbiological finding. C.gingivalis acquired resistance to third generation cephalosporins (bla CfxA3 gene), MLS (erm(F) gene), and fluoroquinolones. Genetics of the resistance, unknown as regards fluoroquinolone, was investigated and a substitution in QRDR of GyrA was described (Gly80Asn substitution) for the first time in the Capnocytophaga genus. A comprehensive literature review of Capnocytophaga spp. extra-oral infection was conducted. Including the present report, on 43 cases, 7 isolates were BL-resistant (17%), 4 isolates were MLS-resistant (9.5%) and 4 isolates were FQ-resistant (9.5%). The studied clinical isolate of C.gingivalis was the only one to combine resistance to the three groups of antibiotics BL, MLS and FQ. Four cases of Capnocytophaga lung infection were reported, including three infections involving C. gingivalis (two FQ resistant) and one involving C. sputigena. This multidrug-resistant C. gingivalis isolate illustrated the role of oral flora as a reservoir of antibiotic resistance and its contribution to the limitation of effective antibiotics in severe respiratory infections. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Automatic Detection and Classification of Pole-Like Objects for Urban Cartography Using Mobile Laser Scanning Data.

    Science.gov (United States)

    Ordóñez, Celestino; Cabo, Carlos; Sanz-Ablanedo, Enoc

    2017-06-22

    Mobile laser scanning (MLS) is a modern and powerful technology capable of obtaining massive point clouds of objects in a short period of time. Although this technology is nowadays being widely applied in urban cartography and 3D city modelling, it has some drawbacks that need to be avoided in order to strengthen it. One of the most important shortcomings of MLS data is concerned with the fact that it provides an unstructured dataset whose processing is very time-consuming. Consequently, there is a growing interest in developing algorithms for the automatic extraction of useful information from MLS point clouds. This work is focused on establishing a methodology and developing an algorithm to detect pole-like objects and classify them into several categories using MLS datasets. The developed procedure starts with the discretization of the point cloud by means of a voxelization, in order to simplify and reduce the processing time in the segmentation process. In turn, a heuristic segmentation algorithm was developed to detect pole-like objects in the MLS point cloud. Finally, two supervised classification algorithms, linear discriminant analysis and support vector machines, were used to distinguish between the different types of poles in the point cloud. The predictors are the principal component eigenvalues obtained from the Cartesian coordinates of the laser points, the range of the Z coordinate, and some shape-related indexes. The performance of the method was tested in an urban area with 123 poles of different categories. Very encouraging results were obtained, since the accuracy rate was over 90%.

  15. A fenestration approach to arytenoid adduction for unilateral vocal cord paralysis. Results of 32 cases

    International Nuclear Information System (INIS)

    Motohashi, Ray; Tokashiki, Ryoji; Hiramatsu, Hiroyuki; Nakamura, Mari; Funato, Nobutoshi; Suzuki, Mamoru

    2009-01-01

    The objective of this study was to develop and evaluate the voice outcomes of an approach to arytenoid adduction (AA) for unilateral vocal cord paralysis through fenestration of the thyroid ala. Thirty-two patients with unilateral vocal cord paralysis underwent laryngoplasty using an approach to AA performed through fenestration of the thyroid ala combined with type I thyroplasty. Thirty-two patients with unilateral vocal cord paralysis were treated between October 2004 and February 2008. In all cases, maximum phonation time (MPT) and mean airflow rate (MFR) were measured before and after the operation. The voices were analyzed using shimmer and jitter. Two surgical windows were made in the lower part of the thyroid ala. The anterior one was for typical type I thyroplasty and the posterior one was for arytenoid adduction (AA). The locations of the two windows were determined based on three-dimensional computer tomography (3DCT) data. AA was performed by muscular process through the posterior window without releasing the cricothyroid joint. The operations were performed under local anesthesia with sedation. Vocal cord medialization was confirmed endoscopically during the operation. Twenty-nine of the 32 patients achieved an MPT of over 10 s after surgery. The other 3 cases, whose MPTs were 9 s after the operation, had low breathing capacity because of lung disease and normal side vocal cord sulcus. The MFRs, which ranged from 236 to 1908 ml/s before the operation, improved to under 200 ml/s except in 3 patients, whose MFRs were 210 ml/s, 214 ml/s and 216 ml/s. Jitter and shimmer improved significantly after the operation. Perceptual evaluation using the GRBAS scale also improved significantly. Our new procedure simplified the combination of AA and type I thyroplasty because the two treatments can be performed in the same operating field, obtaining good voice improvement. Determination of the surgical approach using 3DCT and endoscopic vocal cord observation may

  16. Optical performance of W/B4C multilayer mirror in the soft x-ray region

    Science.gov (United States)

    Pradhan, P. C.; Majhi, A.; Nayak, M.

    2018-03-01

    W/B4C x-ray multilayers (MLs) with 300 layer pairs and a period in the range of d = 2-1.6 nm are fabricated and investigated for the x-ray optical element in the soft x-ray regime. The structural analyses of the MLs are carried out by using hard x-ray reflectivity (HXR) measurements at 8.047 keV. Well-defined successive higher order Bragg peaks (up to 3rd order) in HXR data collected up to glancing incidence angles of ˜9° reveal a good quality of the periodic structure. The ML mirrors have an average interface width of ˜0.35 nm and have a compressive residual stress of ˜0.183 GPa and 0. 827 GPa for d = 1.62 nm and d = 1.98 nm, respectively. MLs maintain structural stability over a long time, with a slight increase in interface widths of the W layers by 0.1 nm due to self-diffusion. Soft x-ray reflectivity (SXR) performances are evaluated in the energy range of 650 to 1500 eV. At energy ˜ 1489 eV, measured reflectivities (energy resolution, ΔE) are ˜ 10% (19 eV) and 4.5% (13 eV) at glancing incident angles of 12.07° and 15° for MLs having periods of 1.98 nm and 1.62 nm, respectively. The optical performance from 1600 eV to 4500 eV is theoretically analysed by considering the measured structural parameters. The structure-stress-optical performance is correlated on the basis of the mechanism of film growth. The implications of W/B4C MLs are discussed, particularly with respect to the development of ML optics with high spectral selectivity and reflectance for soft x-ray instruments.

  17. Shikani Optical Stylet versus Macintosh Laryngoscope for Intubation in Patients Undergoing Surgery for Cervical Spondylosis: A Randomized Controlled Trial.

    Science.gov (United States)

    Xu, Mao; Li, Xiao-Xi; Guo, Xiang-Yang; Wang, Jun

    2017-02-05

    Airway management is critical in patients with cervical spondylosis, a population with a high incidence of difficult airway. Intubation with Shikani Optical Stylet (SOS) has become increasingly popular in difficult airway. We compared the effects of intubation with SOS versus Macintosh laryngoscope (MLS) in patients undergoing surgery for cervical spondylosis. A total of 270 patients scheduled for elective surgery for cervical spondylosis of spinal cord and nerve root type from August 2012 to January 2016 were enrolled and randomly allocated to the MLS or SOS group by random numbers. Patients were evaluated for difficult airway preoperatively, and Cormack-Lehane laryngoscopy classification was determined during anesthesia induction. Difficult airway was defined as Cormack-Lehane Grades III-IV. Patients were intubated with the randomly assigned intubation device. The success rate, intubation time, required assistance, immediate complications, and postoperative complaints were recorded. Categorical variables were analyzed by Chi-square test, and continuous variables were analyzed by independent samples t-test or rank sum test. The success rate of intubation among normal airways was 100% in both groups. In patients with difficult airway, the success rates in the MLS and SOS groups were 84.2% and 94.1%, respectively (P = 0.605). Intubation with SOS took longer compared with MLS (normal airway: 25.1 ± 5.8 s vs. 24.5 ± 5.7 s, P = 0.426; difficult airway: 38.5 ± 8.5 s vs. 36.1 ± 8.2 s, P = 0.389). Intubation with SOS required less assistance in patients with difficult airway (5.9% vs. 100%, Pspondylosis. Compared with MLS, SOS appears clinically beneficial for intubation, especially in patients with difficult airway. Chinese Clinical Trial Registry, ChiCTR-IOR-16007821; http://www.chictr.org.cn/showproj.aspx?proj=13203.

  18. Grounded theory in medical laboratory science expert practice development.

    Science.gov (United States)

    Leibach, Elizabeth Kenimer

    2011-01-01

    Grounded theory and methods related to expert practice development in medical laboratory science were described using data from a large national survey of medical laboratory scientists (MLS) overlaid on findings from analysis of expert practice domains reported in nursing literature. An extensive focus group/expert review iterative process followed by a survey of MLS practitioners produced 25 critical thinking (CT) behaviors important in expert practice. Factor analysis was applied to discern common threads or themes linking the CT behaviors. The 25 important CT behaviors were reduced to a 7-factor structure representing constructs underlying the individual, observable CT behaviors. This 7-factor structure in MLS was compared to the 7 practice domains identified in expert nursing practice. The comparison yielded commonality between MLS and nursing in CT behaviors observed in the 7 expert practice domains of both professions: professional techniques, caring communication, growing professionally, setting priorities, practicing with judgment, anticipating/revising, and creating unique meaning. Emergent grounded theory is that (1) critical thinking is a metaprocess that facilitates learning by interlinking the more basic processes associated with different learning orientations: cognitivist, behaviorist, humanist (affective), and situated/contextual learning, (2) CT behaviors are observable events following from the CT metaprocess, and (3) observations of CT behaviors increase as practice advances from novice to expert. Identification and definition of CT behaviors, i.e., practice competencies, along the continuum of novice to expert can serve as the foundation for MLS curriculum and instructional design as well as measurement and evaluation in both formal and continuing education settings.

  19. Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor

    Directory of Open Access Journals (Sweden)

    Lani S. Chun

    2018-02-01

    Full Text Available The dopamine D2 receptor (D2R is known to elicit effects through activating two major signaling pathways mediated by either G proteins (Gi/o or β-arrestins. However, the specific role of each pathway in physiological or therapeutic activities is not known with certainty. One approach to the dissection of these pathways is through the use of drugs that can selectively modulate one pathway vs. the other through a mechanism known as functional selectivity or biased signaling. Our laboratory has previously described a G protein signaling-biased agonist, MLS1547, for the D2R using a variety of in vitro functional assays. To further evaluate the biased signaling activity of this compound, we investigated its ability to promote D2R internalization, a process known to be mediated by β-arrestin. Using multiple cellular systems and techniques, we found that MLS1547 promotes little D2R internalization, which is consistent with its inability to recruit β-arrestin. Importantly, we validated these results in primary striatal neurons where the D2R is most highly expressed suggesting that MLS1547 will exhibit biased signaling activity in vivo. In an effort to optimize and further explore structure-activity relationships (SAR for this scaffold, we conducted an iterative chemistry campaign to synthesize and characterize novel analogs of MLS1547. The resulting analysis confirmed previously described SAR requirements for G protein-biased agonist activity and, importantly, elucidated new structural features that are critical for agonist efficacy and signaling bias of the MLS1547 scaffold. One of the most important determinants for G protein-biased signaling is the interaction of a hydrophobic moiety of the compound with a defined pocket formed by residues within transmembrane five and extracellular loop two of the D2R. These results shed new light on the mechanism of biased signaling of the D2R and may lead to improved functionally-selective molecules.

  20. Automatic Detection and Classification of Pole-Like Objects for Urban Cartography Using Mobile Laser Scanning Data

    Directory of Open Access Journals (Sweden)

    Celestino Ordóñez

    2017-06-01

    Full Text Available Mobile laser scanning (MLS is a modern and powerful technology capable of obtaining massive point clouds of objects in a short period of time. Although this technology is nowadays being widely applied in urban cartography and 3D city modelling, it has some drawbacks that need to be avoided in order to strengthen it. One of the most important shortcomings of MLS data is concerned with the fact that it provides an unstructured dataset whose processing is very time-consuming. Consequently, there is a growing interest in developing algorithms for the automatic extraction of useful information from MLS point clouds. This work is focused on establishing a methodology and developing an algorithm to detect pole-like objects and classify them into several categories using MLS datasets. The developed procedure starts with the discretization of the point cloud by means of a voxelization, in order to simplify and reduce the processing time in the segmentation process. In turn, a heuristic segmentation algorithm was developed to detect pole-like objects in the MLS point cloud. Finally, two supervised classification algorithms, linear discriminant analysis and support vector machines, were used to distinguish between the different types of poles in the point cloud. The predictors are the principal component eigenvalues obtained from the Cartesian coordinates of the laser points, the range of the Z coordinate, and some shape-related indexes. The performance of the method was tested in an urban area with 123 poles of different categories. Very encouraging results were obtained, since the accuracy rate was over 90%.

  1. Microlenses for optical microsystems

    Science.gov (United States)

    Rocha, Rui Pedro Leitao da Silva

    Lenses have been used by mankind for thousands of years for innumerous different reasons and applications. More recently, lenses in the micro scale dimension, so called microlenses (MLs), have been designed and fabricated using semiconductor technology. These new lenses are used for collimation, focusing or imaging and are an appealing alternative for applications where miniaturization and alignment simplicity are important requirements. Moreover, they also opened a large number of new applications for optical structures and, at the same time, reducing the mechanical and electrical complexity of the existing systems. In this context, the presented thesis has as main purposes, the design and development of a process that allows the fabrication of different sized plano-convex MLs with minor intervention on the process parameters. The MLs were fabricated using a photoresist, the AZ4562, through classical photolithography and the thermal reflow process. Another achievement was the fabrication of MLs directly on the surface of a silicon die containing complementary metal-oxide-semiconductor (CMOS) photodiodes (PDs) for quantifying the differences in their photocurrents generation capacity. The MLs' optimum fabrication process was achieved when a 128k dots per inch (dpi) super high-resolution chrome on soda lime glass 3x3-0.060" photomask was employed. This photomask allows the design pattern to be transferred into the photoresist with very high precision. Nevertheless, for actually obtaining the desired lens profile, it is necessary to apply a thermal treatment to the fabricated microstructures. When the photoresist is submitted to a temperature higher than its glass transition temperature, it softens allowing the shape change to occur. For MLs, the major external force acting during this process is the surface tension. The fabricated MLs were structurally characterized using a profilometer and scanning electron microscope (SEM) images. For measuring the focal length

  2. Comparative exploration of learning styles and teaching techniques between Thai and Vietnamese EFL students and instructors

    Directory of Open Access Journals (Sweden)

    Supalak Nakhornsri

    2016-09-01

    Full Text Available Learning styles have been a particular focus of a number of researchers over the past decades. Findings from various studies researching into how students learn highlight significant relationships between learners’ styles of learning and their language learning processes and achievement. This research focuses on a comparative analysis of the preferences of English learning styles and teaching techniques perceived by students from Thailand and Vietnam, and the teaching styles and techniques practiced by their instructors. The purposes were 1 to investigate the learning styles and teaching techniques students from both countries preferred, 2 to investigate the compatibility of the teaching styles and techniques practiced by instructors and those preferred by the students, 3 to specify the learning styles and teaching techniques students with high level of English proficiency preferred, and 4 to investigate the similarities of Thai and Vietnamese students’ preferences for learning styles and teaching techniques. The sample consisted of two main groups: 1 undergraduate students from King Mongkut’s University of Technology North Bangkok (KMUTNB, Thailand and Thai Nguyen University (TNU, Vietnam and 2 English instructors from both institutions. The instruments employed comprised the Students’ Preferred English Learning Style and Teaching Technique Questionnaire and the Teachers’ Practiced English Teaching Style and Technique Questionnaire. The collected data were analyzed using arithmetic means and standard deviation. The findings can contribute to the curriculum development and assist teachers to teach outside their comfort level to match the students’ preferred learning styles. In addition, the findings could better promote the courses provided for students. By understanding the learning style make-up of the students enrolled in the courses, faculty can adjust their modes of content delivery to match student preferences and maximize

  3. [Multiple dependent variables LS-SVM regression algorithm and its application in NIR spectral quantitative analysis].

    Science.gov (United States)

    An, Xin; Xu, Shuo; Zhang, Lu-Da; Su, Shi-Guang

    2009-01-01

    In the present paper, on the basis of LS-SVM algorithm, we built a multiple dependent variables LS-SVM (MLS-SVM) regression model whose weights can be optimized, and gave the corresponding algorithm. Furthermore, we theoretically explained the relationship between MLS-SVM and LS-SVM. Sixty four broomcorn samples were taken as experimental material, and the sample ratio of modeling set to predicting set was 51 : 13. We first selected randomly and uniformly five weight groups in the interval [0, 1], and then in the way of leave-one-out (LOO) rule determined one appropriate weight group and parameters including penalizing parameters and kernel parameters in the model according to the criterion of the minimum of average relative error. Then a multiple dependent variables quantitative analysis model was built with NIR spectrum and simultaneously analyzed three chemical constituents containing protein, lysine and starch. Finally, the average relative errors between actual values and predicted ones by the model of three components for the predicting set were 1.65%, 6.47% and 1.37%, respectively, and the correlation coefficients were 0.9940, 0.8392 and 0.8825, respectively. For comparison, LS-SVM was also utilized, for which the average relative errors were 1.68%, 6.25% and 1.47%, respectively, and the correlation coefficients were 0.9941, 0.8310 and 0.8800, respectively. It is obvious that MLS-SVM algorithm is comparable to LS-SVM algorithm in modeling analysis performance, and both of them can give satisfying results. The result shows that the model with MLS-SVM algorithm is capable of doing multi-components NIR quantitative analysis synchronously. Thus MLS-SVM algorithm offers a new multiple dependent variables quantitative analysis approach for chemometrics. In addition, the weights have certain effect on the prediction performance of the model with MLS-SVM, which is consistent with our intuition and is validated in this study. Therefore, it is necessary to optimize

  4. Investigations on structural and multiferroic properties of artificially engineered lead zirconate titanate-cobalt iron oxide layered nanostructures

    Science.gov (United States)

    Ortega Achury, Nora Patricia

    Mutiferroics are a novel class of next generation multifunctional materials, which display simultaneous magnetic, electric, and ferroelastic ordering, have drawn increasing interest due to their multi-functionality for a variety of device applications. Since, very rare single phase materials exist in nature this kind of properties, an intensive research activity is being pursued towards the development of new engineered materials with strong magneto-electric (ME) coupling. In the present investigation, we have fabricated polycrystalline and highly oriented PbZr0.53,Ti0.47O3--CoFe 2O4 (PZT/CFO) artificially multilayers (MLs) engineered nanostructures thin films which were grown on Pt/TiO2/SiO2/Si and La 0.5Sr0.5CoO3 (LSCO) coated (001) MgO substrates respectively, using the pulsed laser deposition technique. The effect of various PZT/CFO sandwich configurations having 3, 5, and 9 layers, while maintaining similar total PZT and CFO thickness, has been systematically investigated. The first part of this thesis is devoted to the analysis of structural and microstructure properties of the PZT/CFO MLs. X-ray diffraction (XRD) and micro Raman analysis revealed that PZT and CFO were in the perovskite and spinel phases respectively in the all layered nanostructure, without any intermediate phase. The TEM and STEM line scan of the ML thin films showed that the layered structure was maintained with little inter-diffusion near the interfaces at nano-metric scale without any impurity phase, however better interface was observed in highly oriented films. Second part of this dissertation was dedicated to study of the dielectric, impedance, modulus, and conductivity spectroscopies. These measurements were carried out over a wide range of temperatures (100 K to 600 K) and frequencies (100 Hz to 1 MHz) to investigate the grain and grain boundary effects on electrical properties of MLs. The temperature dependent dielectric and loss tangent illustrated step-like behavior and

  5. Twinning in Zircon: Not a High-Pressure Phenomenon

    Science.gov (United States)

    Jones, G. A.; Moser, D.; Shieh, S. R.; Barker, I.

    2017-12-01

    Microtwins in zircon are commonly found in shocked terrestrial and extraterrestrial samples and are potentially important for shock history and crater reconstruction. Twinning is easily observed with both the optical microscope and variety of electron beam techniques. Twinning as a deformation mechanism is consistent with the high strain rates generated during impact. No constitutive relationships, or even general limits on the physical conditions required for twinning in zircon are known, however. Present speculation on the critical quantity for twin formation, i.e. 10s of GPa of shock pressure (Moser et al. 2011, Timms et al., 2012), has no basis in the underlying mechanisms of twin nucleation, which are related to the motion of dislocations. This erroneous value is due to conflation of twinning sensu stricto with a phase transformation to reidite. Reidite occurs as twin-like lamellae occupying the {112} planes which are thought to be a mirror plane for twinning. We review the crystallographic theory of twinning in zircon. We then evaulate several theories on the nucleation of twins along with their necessary stresses involved. Our aim is to show that shock microtwins in zircon can be a `low pressure' shock phenomenon. This 'low pressure' hypothesis is supported by natural samples. These zircons are from the lower crust nearly 80 km from the centre of the Vredefort impact structure—the most distal zircon shock microstructures yet found in the lithosphere. Twins are present in 10% of the zircon grains greater than 50 µm in diameter. As an extensive, 'low pressure' phenomenon, twins are an easily recognized and potentially widespread record of Earth's impact history.Moser, D.E., Cupelli, C. L., Barker, I., Flowers, R. M., Mowman, J. R., Wooden, J. and Hart, R. (2011) New zircon shock phenomena and their use for dating and […] analysis of the Vredefort dome, Canadian Journal of Earth Sciences 48(2), 117-139.Timms, N.E., Reddy, S. M., Healy, D., Nemchin, A. A

  6. Multilevel architectures for electronic document retrieval

    International Nuclear Information System (INIS)

    Rome, J.A.; Tolliver, J.S.

    1997-01-01

    Traditionally, most classified computer systems run at the highest level of any of the data on the system, and all users must be cleared to this security level. This architecture precludes the use of low-level (pay and clearance) personnel for such tasks as data entry, and makes sharing data with other entities difficult. The government is trying to solve this problem by the introduction of multilevel-secure (MLS) computer systems. In addition, wherever possible, there is pressure to use commercial off-the-shelf software (COTS) to improve reliability, and to reduce purchase and maintenance costs. This paper presents two architectures for an MLS electronic document retrieval system using COTS products. Although the authors believe that the resulting systems represent a real advance in usability, scaleability, and scope, the disconnect between existing security rules and regulations and the rapidly-changing state of technology will make accreditation of such systems a challenge

  7. Mobile Laser Scanning along Dieppe coastal cliffs: reliability of the acquired point clouds applied to rockfall assessments

    Science.gov (United States)

    Michoud, Clément; Carrea, Dario; Augereau, Emmanuel; Cancouët, Romain; Costa, Stéphane; Davidson, Robert; Delacourt, Chirstophe; Derron, Marc-Henri; Jaboyedoff, Michel; Letortu, Pauline; Maquaire, Olivier

    2013-04-01

    Dieppe coastal cliffs, in Normandy, France, are mainly formed by sub-horizontal deposits of chalk and flintstone. Largely destabilized by an intense weathering and the Channel sea erosion, small and large rockfalls are regularly observed and contribute to retrogressive cliff processes. During autumn 2012, cliff and intertidal topographies have been acquired with a Terrestrial Laser Scanner (TLS) and a Mobile Laser Scanner (MLS), coupled with seafloor bathymetries realized with a multibeam echosounder (MBES). MLS is a recent development of laser scanning based on the same theoretical principles of aerial LiDAR, but using smaller, cheaper and portable devices. The MLS system, which is composed by an accurate dynamic positioning and orientation (INS) devices and a long range LiDAR, is mounted on a marine vessel; it is then possible to quickly acquire in motion georeferenced LiDAR point clouds with a resolution of about 15 cm. For example, it takes about 1 h to scan of shoreline of 2 km long. MLS is becoming a promising technique supporting erosion and rockfall assessments along the shores of lakes, fjords or seas. In this study, the MLS system used to acquire cliffs and intertidal areas of the Cap d'Ailly was composed by the INS Applanix POS-MV 320 V4 and the LiDAR Optech Ilirs LR. On the same day, three MLS scans with large overlaps (J1, J21 and J3) have been performed at ranges from 600 m at 4 knots (low tide) up to 200 m at 2.2 knots (up tide) with a calm sea at 2.5 Beaufort (small wavelets). Mean scan resolutions go from 26 cm for far scan (J1) to about 8.1 cm for close scan (J3). Moreover, one TLS point cloud on this test site has been acquired with a mean resolution of about 2.3 cm, using a Riegl LMS Z390i. In order to quantify the reliability of the methodology, comparisons between scans have been realized with the software Polyworks™, calculating shortest distances between points of one cloud and the interpolated surface of the reference point cloud. A Mat

  8. Construction of Response Surface with Higher Order Continuity and Its Application to Reliability Engineering

    Science.gov (United States)

    Krishnamurthy, T.; Romero, V. J.

    2002-01-01

    The usefulness of piecewise polynomials with C1 and C2 derivative continuity for response surface construction method is examined. A Moving Least Squares (MLS) method is developed and compared with four other interpolation methods, including kriging. First the selected methods are applied and compared with one another in a two-design variables problem with a known theoretical response function. Next the methods are tested in a four-design variables problem from a reliability-based design application. In general the piecewise polynomial with higher order derivative continuity methods produce less error in the response prediction. The MLS method was found to be superior for response surface construction among the methods evaluated.

  9. Multi-leaf shielding design against neutrons produced by medical linear accelerators

    International Nuclear Information System (INIS)

    Rebello, W. F.; Silva, A. X.; Facure, A.

    2008-01-01

    This work aims at presenting a study using Monte Carlo simulation of a Multi-leaf Shielding (MLS) System designed to be used for the protection of patients who undergo radiotherapy treatment, against undesired exposure to neutrons produced in the components of the medical linear accelerator heads. The choice of radiotherapy equipment as the subject of study fell on the Varian Clinac 2100/2300 with MLC-120 operating at 18 MeV. The general purpose Monte Carlo N-Particle radiation transport code, MCNP5, was used in the computer simulation in order to determine the ambient dose equivalent, H * (10), on several points on the patient's plane, with the equipment operation with and without the MLS. The results of the simulations showed a significant neutron dose reduction after the inclusion of the proposed shielding. (authors)

  10. Psychometric Properties and Structures of Passionate and Companionate Love

    Directory of Open Access Journals (Sweden)

    Victor Karandashev

    2016-06-01

    Full Text Available After many decades of romantic relationship research, there is a new focus on a multidimensional model of love. This empirical study examines the multidimensionality and psychometrics of Passionate and Companionate love, based on an extensive study of 413 participants using Multidimensional Love Scale (MLS. A new statistical approach employed in this study explores the typology and structure of love. The statistical approach included the combination of Two-Step Cluster Analysis of cases and Principle Component Analysis of dimensions while using centered variable scores. The results reveal a typology of love based on its multidimensional structure. Further analysis revealed two main types of love: Passionate and Companionate, both containing several factors allowing for interpretation of their multidimensional structures. The MLS subscales and detailed psychometric analysis measuring specific love dimensions are incorporated to allow further research in other studies.

  11. Ultra-low thermal conductivity of high-interface density Si/Ge amorphous multilayers

    Science.gov (United States)

    Goto, Masahiro; Xu, Yibin; Zhan, Tianzhuo; Sasaki, Michiko; Nishimura, Chikashi; Kinoshita, Yohei; Ishikiriyama, Mamoru

    2018-04-01

    Owing to their phonon scattering and interfacial thermal resistance (ITR) characteristics, inorganic multilayers (MLs) have attracted considerable attention for thermal barrier applications. In this study, a-Si/a-Ge MLs with layer thicknesses ranging from 0.3 to 5 nm and different interfacial elemental mixture states were fabricated using a combinatorial sputter-coating system, and their thermal conductivities were measured via a frequency-domain thermo-reflectance method. An ultra-low thermal conductivity of κ = 0.29 ± 0.01 W K‑1 m‑1 was achieved for a layer thickness of 0.8 nm. The ITR was found to decrease from 8.5 × 10‑9 to 3.6 × 10‑9 m2 K W‑1 when the interfacial density increases from 0.15 to 0.77 nm‑1.

  12. Prevalence of Genotypes That Determine Resistance of Staphylococci to Macrolides and Lincosamides in Serbia

    Directory of Open Access Journals (Sweden)

    Milena Mišić

    2017-08-01

    Full Text Available Macrolides, lincosamides, and streptogramins (MLS resistance genes are responsible for resistance to these antibiotics in Staphylococcus infections. The purpose of the study was to analyze the distribution of the MLS resistance genes in community- and hospital-acquired Staphylococcus isolates. The MLS resistance phenotypes [constitutive resistance to macrolide–lincosamide–streptogramin B (cMLSb, inducible resistance to macrolide–lincosamide–streptogramin B (iMLSb, resistance to macrolide/macrolide–streptogramin B (M/MSb, and resistance to lincosamide–streptogramin A/streptogramin B (LSa/b] were determined by double-disc diffusion method. The presence of the MLS resistance genes (ermA, ermB, ermC, msrA/B, lnuA, lnuB, and lsaA were determined by end-point polymerase chain reaction in 179 isolates of staphylococci collected during 1-year period at the Center for Microbiology of Public Health Institute in Vranje. The most frequent MLS phenotype among staphylococcal isolates, both community-acquired and hospital-acquired, was iMLSb (33.4%. The second most frequent was M/MSb (17.6% with statistically significantly higher number of hospital-acquired staphylococcal isolates (p < 0.05. MLS resistance was mostly determined by the presence of msrA/B (35.0% and ermC (20.8% genes. Examined phenotypes were mostly determined by the presence of one gene, especially by msrA/B (26.3% and ermC (14.5%, but 15.6% was determined by a combination of two or more genes. M/MSb phenotype was the most frequently encoded by msrA/B (95.6% gene, LSa/b phenotype by lnuA (56.3% gene, and iMLSb phenotype by ermC (29.4% and ermA (25.5% genes. Although cMLSb phenotype was mostly determined by the presence of ermC (28.9%, combinations of two or more genes have been present too. This pattern was particularly recorded in methicillin-resistant Staphylococcus aureus (MRSA (58.3% and methicillin-resistant coagulase-negative staphylococci (MRCNS (90.9% isolates with c

  13. Maxwell-Wagner space charge effects on the Pb(Zr ,Ti)O3-CoFe2O4 multilayers

    Science.gov (United States)

    Ortega, N.; Kumar, Ashok; Katiyar, R. S.; Scott, J. F.

    2007-09-01

    Electrical properties of Pb(Zr0.53Ti0.47)O3/CoFe3O4 (PZT/CFO) multilayers (MLs) were investigated in the light of Maxwell-Wagner space charge effects and the data differ from those of BiFeO3/CoFe3O4 nanocomposites. These MLs are of special interest as weak field sensors of magnetism. These data fit the Maxwell-Wagner space charge model of Catalan et al. [Appl. Phys. Lett. 77, 3078 (2000)]. Very large temperature shifts in dielectric loss peak (>200K ) are indicative of high space charge density at the PZT/CFO interfaces. These conclusions are confirmed by spurious hysteresis loop that are similar to those of highly conducting specimens.

  14. Alcohol injection in the management of paroxysmal trigeminal neuralgia: a report of six cases.

    Science.gov (United States)

    Chindia, M L; Ng'ang'a, P M

    1994-01-01

    The report revisits the role of alcohol in the treatment of paroxysmal trigeminal neuralgia (PTN). The study included 6 patients, 3 male and 3 female, average age 50 years. In 3 cases PTN involved both the infraorbital and mental nerves; in 2 cases the infraorbital alone while one case had buccal branch involvement. In each case 2mls standard Lignocaine was infiltrated at each site followed by 2mls 60% sterile alcohol. All patients reported swelling postoperatively. One case with mental and infraorbital nerve involvement complained of oral dysaesthesia. Another patient with similar involvement failed to respond and developed trismus. Responders remained pain-free for 9 months on average. While paroxysmal trigeminal neuralgia (PTN) has been recognised for centuries, the aetiology and definitive treatment remain obscure. Since this is a debilitating condition, management should aim at improving the quality of life. Alcohol is available, affordable and offers useful results where medical resources provide limited PTN treatment modalities.

  15. A Review on the Toxicity and Non-Target Effects of Macrocyclic Lactones in Terrestrial and Aquatic Environments

    OpenAIRE

    Lumaret, Jean-Pierre; Errouissi, Faiek; Floate, Kevin; Römbke, Jörg; Wardhaugh, Keith

    2012-01-01

    The avermectins, milbemycins and spinosyns are collectively referred to as macrocyclic lactones (MLs) which comprise several classes of chemicals derived from cultures of soil micro-organisms. These compounds are extensively and increasingly used in veterinary medicine and agriculture. Due to their potential effects on non-target organisms, large amounts of information on their impact in the environment has been compiled in recent years, mainly caused by legal requirements related to their ma...

  16. In vivo breast sound-speed imaging with ultrasound tomography

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Lianjie [Los Alamos National Laboratory; Li, Cuiping [KARMANOS CANCER INSTITUTE; Duric, Neb [KARMANOS CANCER INSTITUTE; Littrup, Peter [KARMONOS CANCER INSTITUTE

    2009-01-01

    We discuss a bent-ray ultrasound tomography algorithm with total-variation (TV) regularization. We have applied this algorithm to 61 in vivo breast datasets collected with our in-house clinical prototype for imaging sound-speed distributions in the breast. Our analysis showed that TV regularization could preserve sharper lesion edges than the classic Tikhonov regularization. Furthermore, the image quality of our TV bent-ray sound-speed tomograms was superior to that of the straight-ray counterparts for all types of breasts within BI-RADS density categories 1-4. For all four breast types from fatty to dense, the improvements for average sharpness (in the unit of (m{center_dot} s) {sup -1}) of lesion edges in our TV bent-ray tomograms are between 2.1 to 3.4 fold compared to the straight ray tomograms. Reconstructed sound-speed tomograms illustrated that our algorithm could successfully image fatty and glandular tissues within the breast. We calculated the mean sound-speed values for fatty tissue and breast parenchyma as 1422 {+-} 9 mls (mean{+-} SD) and1487 {+-} 21 mls, respectively. Based on 32 lesions in a cohort of 61 patients, we also found that the mean sound-speed for malignant breast lesions (1548{+-}17 mls) was higher, on average, than that of benign ones (1513{+-}27 mls) (one-sided p

  17. Phenotypic detection of inducible clindamycin resistance among Staphylococcus aureus isolates by using the lower limit of recommended inter-disk distance

    OpenAIRE

    Ajantha G; Kulkarni Raghavendra; Shetty Jeevan; Shubhada C; Jain Pavithra

    2008-01-01

    Context: Clindamycin is one of the important alternative antibiotics in the therapy of Staphylococcus aureus, particularly in methicillin-resistant S. aureus (MRSA) infections. Inducible clindamycin resistance (iMLS B - inducible Macrolide-Lincosamide-Streptogramin B resistance) is a critical factor in antimicrobial susceptibility testing. Aims: To know the rate of inducible clindamycin resistance among clinical isolates of Staphylococcus aureus in our hospital by Disk approximation test ...

  18. Hang in There: How to Get a Library Job against All Odds

    Science.gov (United States)

    Von Drasek, Lisa

    2011-01-01

    It is enough to make a resourceful media specialist wonder whether she will still have a job at the end of the school year or will need to find a new one. And it is not just experienced media specialists who are anxious. A teacher completing her MLS recently wrote on LM_NET that she was worried about getting a job after graduation. With all the…

  19. [Combination of the ureteral dilation catheter and balloon catheter under the ureteroscope in the treatment of male urethral stricture].

    Science.gov (United States)

    Zhou, Yi; Li, Gong-hui; Yan, Jia-jun; Shen, Cong; Tang, Gui-hang; Xu, Gang

    2016-01-01

    To investigate the clinical application of the ureteral dilation catheter combined with the balloon catheter under the ureteroscope in the treatment of urethral stricture in men. Under the ureteroscope, 45 male patients with urethral stricture received placement of a zebra guide wire through the strictured urethra into the bladder and then a ureteral dilation catheter along the guide wire, followed by dilation of the urethra from F8 initially to F14 and F16. Again, the ureteroscope was used to determine the length of the strictured urethra, its distance to the external urethral orifice, and whether it was normally located. An F24 balloon catheter and then a metal urethral calibrator was used for the dilation of the strictured urethra. After removal of the F18-F22 urethral catheter at 8 weeks, the urinary flow rate was measured immediately and again at 3 months. All the operations were successfully performed without serious complications. The maximum urinary flow rate was (13.3-29.9) ml/s (mean [17.7 ± 3.2] ml/s) at the removal of the catheter and (15.2-30.8) ml/s (mean [19.8 ± 3.9] ml/s) at 3 months after it. Smooth urination was found in all the patients during the 6-24 months follow-up. The application of the ureteral dilation catheter combined with, the balloon catheter under the ureteroscope is a good option for the treatment of male urethral stricture for its advantages of uncomplicatedness, safety, effectiveness, few complications, less pain, high success rate, and repeatable operation.

  20. Is There Evidence of Convectively Injected Water Vapor in the Lowermost Stratosphere Over Boulder, Colorado?

    Science.gov (United States)

    Hurst, D. F.; Rosenlof, K. H.; Davis, S. M.; Hall, E. G.; Jordan, A. F.

    2014-12-01

    Anderson et al. (2012) reported the frequent presence of convectively injected water vapor in the lowermost stratosphere over North America during summertime, based on aircraft measurements. They asserted that enhanced catalytic ozone destruction within these wet stratospheric air parcels presents a concern for UV dosages in populated areas, especially if the frequency of deep convective events increases. Schwartz et al.(2013) analyzed 8 years of more widespread Aura Microwave Limb Sounder (MLS) measurements of lower stratospheric water vapor over North America and concluded that anomalously wet (>8 ppm) air parcels were present only 2.5% of the time during July and August. However, given the 3-km vertical resolution of MLS water vapor retrievals in the lowermost stratosphere, thin wet layers deposited by overshooting convection may be present but not readily detectable by MLS. Since 1980 the balloon-borne NOAA frost point hygrometer (FPH) has produced nearly 400 high quality water vapor profiles over Boulder, Colorado, at 5-m vertical resolution from the surface to the middle stratosphere. The 34-year record of high-resolution FPH profiles obtained over Boulder during summer months is evaluated for evidence of convectively injected water vapor in the lowermost stratosphere. A number of approaches are used to assess the contributions of deep convection to the Boulder stratospheric water vapor record. The results are compared to those based on MLS profiles over Boulder and the differences are discussed. Anderson, J. G., D. M. Wilmouth, J. B. Smith, and D. S. Sayres (2012), UV dosage levels in summer: Increased risk of ozone loss from convectively injected water vapor, Science, 337(6096), 835-839, doi:10.1126/science.1222978. Schwartz, M. J., W. G. Read, M. L. Santee, N. J. Livesey, L. Froidevaux, A. Lambert, and G. L. Manney (2013), Convectively injected water vapor in the North American summer lowermost stratosphere, Geophys. Res. Lett., 40, 2316-2321, doi:10

  1. Bioassay using the water soluble fraction of a Nigerian Light Crude ...

    African Journals Online (AJOL)

    Summary: A 96-hour bioassay was conducted using the water soluble fraction of a Nigerian light crude oil sample on Clarias gariepinus fingerlings. 0, 2.5, 5.0, 7.5 and 10 mls of water soluble fractions (WSF) of the oil were added to 1000 litres of de-chlorinated tap water to form 0, 25, 50 , 75 and 100 parts per million ...

  2. The Oxidation of a Gasoline Surrogate in the Negative Temperature Coefficient Region

    Science.gov (United States)

    2009-02-12

    total hydrocarbon ( THC ) analyzer, and a multiple loop sample (MLS) storage system for offline analysis of up to 14 stored samples collected at selected...surrogate (GS4c-1).The offline analysis of the stable intermediate species was ac- complished with a gas chromatograph ( GC ) with a flame ionization...02 database (145,000+ unique compounds) [11]. Con- centration of the identified compounds was determined primarily using the FID in the GC . Compounds

  3. Analýza struktury trhu práce: MAJOR LEAGUE SOCCER

    OpenAIRE

    Hrdina, Martin

    2013-01-01

    This thesis deals with the determination of the player labour market for the American professional sports league Major League Soccer (MLS). In the theoretical part I focus on the description of the league's development along with the salary politics rules. Using the two stages least square method in the empirical part I then provide the model for the estimation of player's marginal productivity (MRP). In the first step I explain the correlation between the percentages of obtained points by te...

  4. CuO/V2O5-Codoped Bi3/2ZnNb3/2O7 (BZN) Ceramic for Embedded Capacitor Layer in Integrated LTCC Modules

    Science.gov (United States)

    Lee, Kyoungho; Kang, Seungjin

    2016-06-01

    Sintering additives for Bi3/2ZnNb3/2O7 (BZN) ceramic have been studied to facilitate use of BZN as a material for embedded decoupling capacitors in high-density multilayered low-temperature cofired ceramic (LTCC) modules for mobile communication systems and three-dimensional printing modules. Among the additives studied, a CuO/V2O5 mixture was the most promising for cofiring BZN ceramic with a commercial low-permittivity ( ɛ r) LTCC sheet (MLS-22; NEG Co., Japan) and Ag electrode. BZN codoped with 0.5 wt.% CuO/V2O5 was successfully densified at 860°C by reactive liquid-phase sintering, and the resulting dielectric properties were acceptable for use of the CuO/V2O5-codoped BZN for embedded capacitors in LTCC modules. The room-temperature permittivity ( ɛ r) of the CuO/V2O5-codoped BZN was 148 at 1 MHz, and the capacitance thermal stability was ±1.3% within the temperature range of -55°C to 125°C. The physical and chemical compatibilities of the CuO/V2O5-codoped BZN with heterogeneous layers (low- ɛ r LTCC layer and Ag electrode layer) in LTCC modules were also examined. A cofiring test of the doped BZN ceramic with MLS-22 LTCC sheet revealed that thickness control of the two heterogeneous layers was a key factor to avoid crack formation during cofiring. The optimum thickness ratio of doped BZN to MLS-22 layers was less than 0.25:1. A chemical compatibility test revealed no severe reaction between the doped BZN/MLS-22 and doped BZN/Ag layers.

  5. Differentiating between adductor and abductor spasmodic dysphonia using airflow interruption

    Science.gov (United States)

    Hoffman, Matthew R.; Jiang, Jack J.; Rieves, Adam L.; McElveen, Kelsey A.B.; Ford, Charles N.

    2009-01-01

    Objective To measure the laryngeal resistance (RL), subglottal pressure (Ps), and mean flow rate (MFR) of adductor (ADSD) and abductor (ABSD) spasmodic dysphonia patients using the airflow interrupter. Methods The RL of six ABSD and seven ADSD patients was measured using the airflow interrupter, a noninvasive device designed to measure MFR and Ps via mechanical balloon valve interruption. Subjects performed ten trials at each of two intensity levels, with each trial consisting of a sustained /a/ during which phonation was interrupted for 500 ms. Laryngeal resistance was calculated as subglottal pressure divided by airflow. Results Mean RL for the ADSD and ABSD subtypes at 65 dB were 24.78 cmH2O/l/s and 14.51 cmH2O/l/s, respectively (p = 0.04). Mean RL at 70 dB were 40.02 cmH2O/l/s and 15.84 cmH2O/l/s (p = 0.014). Ps for the ADSD and ABSD subtypes at 65 dB were 10.23 cmH2O and 8.32 cmH2O, respectively (p = 0.582). At the 70 dB level, Ps were 12.39 cmH2O and 11.78 cmH2O (p = 0.886). MFR for the ADSD and ABSD subtypes at 65 dB were 435 ml/s and 746 ml/s (p = 0.205). Mean MFR at 70 dB were 518 ml/s and 848 ml/s (p = 0.198). Conclusion Noninvasive measurements of RL may be useful for differentiating between ADSD and ABSD. This simple objective test which produces a quantitative output could be used to evaluate laryngeal function in patients with spasmodic dysphonia. PMID:19554636

  6. Evaluation of renal allograft with 99mTc-mononuclear leukocytes

    International Nuclear Information System (INIS)

    Souza, S.A.L.; Oliveira, H.S.; Goncalves, R.T.; Pontes, D.S.; Fonseca, L.B.M.; Gutfilen, B.

    2002-01-01

    Aim: Because kidney biopsy is an invasive procedure that carries a small but significant risk of major complications, a noninvasive test that detects rejection before it is clinically apparent is very much needed. The reversibility of acute rejection is related to the promptness with which treatment is begun. Here we show the evaluation of rejection in the first week post-transplant with 99m Tc-mononuclear leukocyte scintigraphy (99mTc-MLS). Materials and Methods: 70 patients submitted to renal transplant at the Hospital Universitario Clementino Fraga Filho (HUCFF/UFRJ) underwent 99m Tc-MLS at the 1st and 5th post-transplant days. The labeled cells were administered (444MBq) and scans were carried out 3 and 24h post injection. A region of interest (ROI) was drawn at the allograft image and statistics compared between the 3 and 24h images. Percentages above 15% in the 24h image relating to the 3h image were considered abnormal and suspect of rejection. 25 of the 70 patients rejected the renal allograft in the 1st week post-transplant. Results: 99m Tc-MLS has detected rejection in 20 of the 25 patients. Color Doppler was also carried out in all the patients and has detected 16 rejections. Sensitivity and specificity were 80% and 100% for scintigraphy and 64% and 100% for Ultrasound. 99m Tc-MLS is more sensitive in humoral rejection than color Doppler. The latter is better to identify the vascular rejection. Conclusion: In order to evaluate renal allograft and improve the rejection diagnosis the combination of both techniques should be applied. More studies are now in progress

  7. Summary Report on NRL Participation in the Microwave Landing System Program.

    Science.gov (United States)

    1980-08-19

    bifocal folded pillbox for the elevation unit and a parabolic torus for the azimuth u-nit. Although these mictowave optical designs were felt to be...Bendix/E{S ferrite latching four- bit units and two TI diode four-bit units were tested using an automatic network analyzer available at NRL. A computer... automatic landing. MLS provides azimuth angle information over a region +60 deg. relative to runway center line with vertical coverage to +20 deg

  8. Differentiating between adductor and abductor spasmodic dysphonia using airflow interruption.

    Science.gov (United States)

    Hoffman, Matthew R; Jiang, Jack J; Rieves, Adam L; McElveen, Kelsey A B; Ford, Charles N

    2009-09-01

    To measure the laryngeal resistance (R(L)), subglottal pressure (P(s)), and mean flow rate (MFR) of adductor (ADSD) and abductor (ABSD) spasmodic dysphonia patients using the airflow interrupter. The R(L) of six ABSD and seven ADSD patients was measured using the airflow interrupter, a noninvasive device designed to measure MFR and P(s) via mechanical balloon valve interruption. Subjects performed 10 trials at each of two intensity levels, with each trial consisting of a sustained /a/ during which phonation was interrupted for 500 ms. Laryngeal resistance was calculated as subglottal pressure divided by airflow. Mean R(L) for the ADSD and ABSD subtypes at 65 dB were 24.78 cmH(2)O/L/s and 14.51 cmH(2)O/L/s, respectively (P = .04). Mean R(L) at 70 dB were 40.02 cmH(2)O/L/s and 15.84 cmH(2)O/L/s (P = .014). P(s) for the ADSD and ABSD subtypes at 65 dB were 10.23 cmH(2)O and 8.32 cmH(2)O, respectively (P = .582). At the 70 dB level, P(s) were 12.39 cmH(2)O and 11.78 cmH(2)O (P = .886). MFR for the ADSD and ABSD subtypes at 65 dB were 435 mL/s and 746 mL/s (P = .205). Mean MFR at 70 dB were 518 mL/s and 848 mL/s (P = .198). Noninvasive measurements of R(L) may be useful for differentiating between ADSD and ABSD. This simple objective test, which produces a quantitative output, could be used to evaluate laryngeal function in patients with spasmodic dysphonia.

  9. Barriers to creating a secure MPI

    Energy Technology Data Exchange (ETDEWEB)

    Brightwell, R.; Greenberg, D.S.; Matt, B.J. [Sandia National Labs., Albuquerque, NM (United States); Davida, G.I. [Univ. of Wisconsin, Milwaukee, WI (United States). Dept. of Computer Sciences

    1997-08-01

    This paper explores some of the many issues in developing security enhanced MPI for embedded real-time systems supporting the Department of Defense`s Multi-level Security policy (DoD MLS) are presented along with the preliminary design for such an MPI variant. In addition some of the many issues that need to be addressed in creating security enhanced versions of MPI for other domains are discussed. 19 refs.

  10. Newcastle Disease Virus: Potential Therapeutic Application for Human and Canine Lymphoma

    Directory of Open Access Journals (Sweden)

    Diana Sánchez

    2015-12-01

    Full Text Available Research on oncolytic viruses has mostly been directed towards the treatment of solid tumors, which has yielded limited information regarding their activity in hematological cancer. It has also been directed towards the treatment of humans, yet veterinary medicine may also benefit. Several strains of the Newcastle disease virus (NDV have been used as oncolytics in vitro and in a number of in vivo experiments. We studied the cytolytic effect of NDV-MLS, a low virulence attenuated lentogenic strain, on a human large B-cell lymphoma cell line (SU-DHL-4, as well as on primary canine-derived B-cell lymphoma cells, and compared them to healthy peripheral blood mononuclear cells (PBMC from both humans and dogs. NDV-MLS reduced cell survival in both human (42% ± 5% and dog (34% ± 12% lymphoma cells as compared to untreated controls. No significant effect on PBMC was seen. Cell death involved apoptosis as documented by flow-cytometry. NDV-MLS infections of malignant lymphoma tumors in vivo in dogs were confirmed by electron microscopy. Early (24 h biodistribution of intravenous injection of 1 × 1012 TCID50 (tissue culture infective dose in a dog with T-cell lymphoma showed viral localization only in the kidney, the salivary gland, the lung and the stomach by immunohistochemistry and/or endpoint PCR. We conclude that NDV-MLS may be a promising agent for the treatment of lymphomas. Future research is needed to elucidate the optimal therapeutic regimen and establish appropriate biosafety measures.

  11. National Computer Security Conference (15th) held in Baltimore, Maryland on October 13-16, 1992. Volume 2: Proceedings

    Science.gov (United States)

    1992-10-16

    essential in order to build systems that are more economical , functional, or aesthetically pleasing than their predecessors. Moreover, we learn more... essential to widespread user acceptance of MLS systems. RELATED WQR* Many researchers have addressed aspects of these problems. Biba14 and Clark and...processes, discovering that policies may conflict and that policies about policies may be necessary.23 Moffet and Sloman explored management

  12. USE OF POWERED INSTRUMENTATION IN MICROLARYNGEAL SURGERY: A CLINICAL STUDY

    OpenAIRE

    Shankar; Benjamin Rajendra

    2015-01-01

    Micro laryngeal surgery is a common and relatively safe ENT surgery, certain laryngeal conditions require surgery for correction. Surgery for voice problems is quite uncommon, most of the voice disorders can be treated with voice therapy or medical treatment. However there are certain conditions may required operative measures. We have been doing micro laryngeal surgery(MLS) in our institute for quite a long time, but use of powered instruments like, microdebrider technique in...

  13. Characterizing sampling and quality screening biases in infrared and microwave limb sounding

    Science.gov (United States)

    Millán, Luis F.; Livesey, Nathaniel J.; Santee, Michelle L.; von Clarmann, Thomas

    2018-03-01

    This study investigates orbital sampling biases and evaluates the additional impact caused by data quality screening for the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) and the Aura Microwave Limb Sounder (MLS). MIPAS acts as a proxy for typical infrared limb emission sounders, while MLS acts as a proxy for microwave limb sounders. These biases were calculated for temperature and several trace gases by interpolating model fields to real sampling patterns and, additionally, screening those locations as directed by their corresponding quality criteria. Both instruments have dense uniform sampling patterns typical of limb emission sounders, producing almost identical sampling biases. However, there is a substantial difference between the number of locations discarded. MIPAS, as a mid-infrared instrument, is very sensitive to clouds, and measurements affected by them are thus rejected from the analysis. For example, in the tropics, the MIPAS yield is strongly affected by clouds, while MLS is mostly unaffected. The results show that upper-tropospheric sampling biases in zonally averaged data, for both instruments, can be up to 10 to 30 %, depending on the species, and up to 3 K for temperature. For MIPAS, the sampling reduction due to quality screening worsens the biases, leading to values as large as 30 to 100 % for the trace gases and expanding the 3 K bias region for temperature. This type of sampling bias is largely induced by the geophysical origins of the screening (e.g. clouds). Further, analysis of long-term time series reveals that these additional quality screening biases may affect the ability to accurately detect upper-tropospheric long-term changes using such data. In contrast, MLS data quality screening removes sufficiently few points that no additional bias is introduced, although its penetration is limited to the upper troposphere, while MIPAS may cover well into the mid-troposphere in cloud-free scenarios. We emphasize that the

  14. Magnetic resonance evaluation of renal artery stenosis in a swine model: performance of low-dose gadobutrol versus gadoterate meglumine in comparison with digital subtraction intra-arterial catheter angiography.

    Science.gov (United States)

    Morelli, John N; Runge, Val M; Ai, Fei; Zhang, Wei; Li, Xiaoming; Schmitt, Peter; McNeal, Gary; Miller, Matthew; Lennox, Mark; Wusten, Oliver; Schoenberg, Stefan O; Attenberger, Ulrike I

    2012-06-01

    The aim of this study was to compare low-dose imaging with gadobutrol and gadoterate meglumine (Gd-DOTA) for evaluation of renal artery stenosis with 3-T magnetic resonance angiography (MRA) in a swine model. A total of 12 experimental animals were evaluated using equivalently dosed gadobutrol and Gd-DOTA for time-resolved and static imaging. For time-resolved imaging, the time-resolved imaging with stochastic trajectories (TWIST) technique (temporal footprint, 4.4 seconds) was used; a dose of 1 mL of gadobutrol was injected at 2 mL/s and a dose of 2 mL of Gd-DOTA was injected at both 2 and 4 mL/s. For a separate static acquisition, doses were doubled. The static scans were used for stenosis gradation and the time-resolved scans for comparison of enhancement dynamics, signal-to-noise ratio (SNR), and qualitative assessments. The average magnitude of difference in the stenosis measurements with static gadobutrol scans relative to digital subtraction intra-arterial catheter angiography (mean [SD], 7.4% [5.6%]) was less than with both the 2 mL/s (10.6% [6.2%]) and 4 mL/s (11.5% [7.8%]) Gd-DOTA MRA protocols. On time-resolved scans, peak signal-to-noise ratio was greatest with the gadobutrol protocol (P < 0.05), and the gadobutrol TWIST scan was preferred to the TWIST Gd-DOTA scan in terms of image quality and stenosis visualization in every case for every reader. Low-dose gadobutrol (~0.05 mmoL/kg) contrast-enhanced MRA results in improved accuracy of renal artery stenosis assessments relative to equivalently dosed Gd-DOTA at 3 T.

  15. Vibration and Buckling Analysis of Unitized Structure Using Meshfree Method and Kriging Model

    OpenAIRE

    Yeilaghi Tamijani, Ali

    2011-01-01

    The Element Free Galerkin (EFG) method, which is based on the Moving Least Squares (MLS) approximation, is developed here for vibration, buckling and static analysis of homogenous and FGM plate with curvilinear stiffeners. Numerical results for different stiffeners configurations and boundary conditions are presented. All results are verified using the commercial finite element software ANSYS® and other available results in literature. In addition, the vibration analysis of plates with c...

  16. Comparative evaluation of marginal fit and axial wall adaptability of copings fabricated by metal laser sintering and lost-wax technique: Anin vitrostudy.

    Science.gov (United States)

    Gaikwad, Bhushan Satish; Nazirkar, Girish; Dable, Rajani; Singh, Shailendra

    2018-01-01

    The present study aims to compare and evaluate the marginal fit and axial wall adaptability of Co-Cr copings fabricated by metal laser sintering (MLS) and lost-wax (LW) techniques using a stereomicroscope. A stainless steel master die assembly was fabricated simulating a prepared crown; 40 replicas of master die were fabricated in gypsum type IV and randomly divided in two equal groups. Group A coping was fabrication by LW technique and the Group B coping fabrication by MLS technique. The copings were seated on their respective gypsum dies and marginal fit was measured using stereomicroscope and image analysis software. For evaluation of axial wall adaptability, the coping and die assembly were embedded in autopolymerizing acrylic resin and sectioned vertically. The discrepancies between the dies and copings were measured along the axial wall on each halves. The data were subjected to statistical analysis using unpaired t -test. The mean values of marginal fit for copings in Group B (MLS) were lower (24.6 μm) than the copings in Group A (LW) (39.53 μm), and the difference was statistically significant ( P < 0.05). The mean axial wall discrepancy value was lower for Group B (31.03 μm) as compared with Group A (54.49 μm) and the difference was statistically significant ( P < 0.05). The copings fabricated by MLS technique had better marginal fit and axial wall adaptability in comparison with copings fabricated by the LW technique. However, the values of marginal fit of copings fabricated that the two techniques were within the clinically acceptable limit (<50 μm).

  17. Distribution, characterization and genetic bases of erythromycin resistance in staphylococci and enterococci originating from livestock.

    Science.gov (United States)

    Jaglic, Z; Vlkova, H; Bardon, J; Michu, E; Cervinkova, D; Babak, V

    2012-05-01

    The occurrence of staphylococci and enterococci expressing increased resistance to erythromycin (ERY) and, in particular, to macrolide-lincosamide-streptogramin B (MLS(B) ) antibiotics was investigated in dairy cattle, pigs and turkeys. Three hundred rectal (cloacal) swabs of each animal species were examined. A total of 120 and 71 staphylococci and enterococci, respectively, with increased resistance to ERY were identified. These were most frequent in turkeys (42.3% of positive animals), followed by pigs and dairy cattle (6.7% and 6.0% of positive animals, respectively). Similarly, MLS(B) -resistant isolates colonized predominantly turkeys (29.7% of animals), while their occurrence in pigs and dairy cattle was only sporadic (0.8% of animals). At least one of the erm genes encoding for MLS(B) resistance was found in 56.7% and 69.0% of staphylococci and enterococci, respectively. The erm(C) gene prevailed in staphylococci while the erm(B) gene was predominant in enterococci. Macrolide efflux genes msr(A) and msr(C) were also frequent in staphylococci and enterococci, respectively. Macrolide inactivation gene mph(C) occurred mainly in staphylococci. In staphylococci, methicillin resistance was rarely detected (7.5% of isolates), but resistance to telithromycin (ketolides) was frequent in both staphylococci and enterococci (89.2% and 47.9% of isolates, respectively). This study showed that turkeys represent an important source of ERY (MLS(B) )-resistant cocci. In addition, resistance to ketolides was also frequent. © 2011 Blackwell Verlag GmbH.

  18. Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome

    OpenAIRE

    Shah, Ashok; Gera, Kamal; Panjabi, Chandramani

    2016-01-01

    Allergic bronchopulmonary aspergillosis (ABPA) is infrequently documented in children with asthma. Although collapse is not uncommon, middle lobe syndrome (MLS) as a presentation of ABPA is rather a rarity. A 9-year-old female child with asthma presented with increase in intensity of symptoms along with a right midzone patchy consolidation on a chest radiograph. In addition, an ill-defined opacity abutting the right cardiac border with loss of cardiac silhouette was noted. A right lateral vie...

  19. Assessment of RFID Investment in the Military Logistics Systems Through The Life Cycle Cost (LCC) Model

    OpenAIRE

    Ozdemir, Ahmet; Bayrak, Mustafa

    2015-01-01

    Radio Frequency Identification (RFID) is an emerging technology that has been recently used in numerous business and public fields. Most military applications of RFID have focused on logistics systems. Since RFID investment requires high initial cost and its benefits are hard to see in the short term, it needs an appropriate investment decision model. The purpose of this research is to propose a Life Cycle Cost (LCC) model for RFID integration into the Military Logistics System (MLS). The stu...

  20. Characterization of Minnesota lunar simulant for plant growth

    Science.gov (United States)

    Oglesby, James P.; Lindsay, Willard L.; Sadeh, Willy Z.

    1993-01-01

    Processing of lunar regolith into a plant growth medium is crucial in the development of a regenerative life support system for a lunar base. Plants, which are the core of such a system, produce food and oxygen for humans and, at the same time, consume carbon dioxide. Because of the scarcity of lunar regolith, simulants must be used to infer its properties and to develop procedures for weathering and chemical analyses. The Minnesota Lunar Simulant (MLS) has been identified to date as the best available simulant for lunar regolith. Results of the dissolution studies reveal that appropriately fertilized MLS can be a suitable medium for plant growth. The techniques used in conducting these studies can be extended to investigate the suitability of actual lunar regolith as a plant growth medium. Dissolution experiments were conducted using the MLS to determine its nutritional and toxicity characteristics for plant growth and to develop weathering and chemical analysis techniques. Two weathering regimes, one with water and one with dilute organic acids simulating the root rhizosphere microenvironment, were investigated. Elemental concentrations were measured using inductively-coupled-plasma (ICP) emission spectrometry and ion chromatography (IC). The geochemical speciation model, MINTEQA2, was used to determine the major solution species and the minerals controlling them. Acidification was found to be a useful method for increasing cation concentrations to meaningful levels. Initial results indicate that MLS weathers to give neutral to slightly basic solutions which contain acceptable amounts of the essential elements required for plant nutrition (i.e., potassium, calcium, magnesium, sulfur, zinc, sodium, silicon, manganese, copper, chlorine, boron, molybdenum, and cobalt). Elements that need to be supplemented include carbon, nitrogen, and perhaps phosphorus and iron. Trace metals in solution were present at nontoxic levels.