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Sample records for time-trial tt performance

  1. The Reproducibility of 4-km Time Trial (TT) Performance Following Individualised Sodium Bicarbonate Supplementation: a Randomised Controlled Trial in Trained Cyclists.

    Science.gov (United States)

    Gough, Lewis Anthony; Deb, Sanjoy Kumar; Sparks, Andy; McNaughton, Lars Robert

    2017-09-21

    Individual time to peak blood bicarbonate (HCO 3 - ) has demonstrated good to excellent reproducibility following ingestion of both 0.2 g kg -1 body mass (BM) and 0.3 g kg -1 BM sodium bicarbonate (NaHCO 3 ), but the consistency of the time trial (TT) performance response using such an individualised NaHCO 3 ingestion strategy remains unknown. This study therefore evaluated the reproducibility of 4-km TT performance following NaHCO 3 ingestion individualised to time to peak blood bicarbonate. Eleven trained male cyclists completed five randomised treatments with prior ingestion of 0.2 g kg -1 (SBC2) or 0.3 g kg -1 BM (SBC3) NaHCO 3 , on two separate occasions each, or a control trial entailing no supplementation. Participants completed a 4-km cycling TT on a Velotron ergometer where time to complete, power and speed were measured, whilst acid-base blood parameters were also recorded (pH and blood bicarbonate concentration HCO 3 - ) and lactate [La - ]. Alkalosis was achieved prior to exercise in both SBC2 and SBC3, as pH and HCO 3 - were greater compared to baseline (p  0.05). The reproducibility of the mean absolute change from baseline to peak in HCO 3 - was good in SBC2 (r = 0.68) and excellent in SBC3 (r = 0.78). The performance responses following both SBC2 and SBC3 displayed excellent reproducibility (r range = 0.97 to 0.99). Results demonstrate excellent reproducibility of exercise performance following individualised NaHCO 3 ingestion, which is due to the high reproducibility of blood acid-base variables with repeat administration of NaHCO 3 . Using a time to peak HCO 3 - strategy seems to cause no dose-dependent effects on performance for exercise of this duration and intensity; therefore, athletes may consider smaller doses of NaHCO 3 to mitigate gastrointestinal (GI) discomfort.

  2. Ad-libitum drinking and performance during a 40-km cycling time trial in the heat

    NARCIS (Netherlands)

    Berkulo, M.A.R.; Bol, S.; Levels, K.; Lamberts, R.P.; Daanen, H.A.M.; Noakes, T.D.

    2015-01-01

    The aim of this study was to investigate if drinking ad-libitum can counteract potential negative effects of a hypohydrated start caused by fluid restriction during a 40-km time trial (TT) in the heat. Twelve trained males performed one 40-km cycling TT euhydrated (EU: no water during the TT) and

  3. Ad-libitum drinking and performance during a 40-km cycling time trial in the heat

    NARCIS (Netherlands)

    Berkulo, M.A.R.; Bol, S.; Levels, K.; Lamberts, R.P.; Daanen, H.A.M.; Noakes, T.D.

    2016-01-01

    The aim of this study was to investigate if drinking ad-libitum can counteract potential negative effects of a hypohydrated start caused by fluid restriction during a 40-km time trial (TT) in the heat. Twelve trained males performed one 40-km cycling TT euhydrated (EU: no water during the TT) and

  4. Sodium Phosphate Supplementation and Time Trial Performance in Female Cyclists

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    Christopher L. Buck

    2014-09-01

    Full Text Available This study investigated the effects of three doses of sodium phosphate (SP supplementation on cycling 500 kJ (119.5 Kcal time trial (TT performance in female cyclists. Thirteen cyclists participated in a randomised, Latin-square design study where they completed four separate trials after ingesting either a placebo, or one of three different doses (25, 50 or 75 mg·kg-1 fat free mass: FFM of trisodium phosphate dodecahydrate which was split into four equal doses a day for six days. On the day after the loading phase, the TT was performed on a cycle ergometer. Serum phosphate blood samples were taken at rest both before and after each loading protocol, while a ~21 day washout period separated each loading phase. No significant differences in TT performance were observed between any of the supplementation protocols (p = 0.73 with average completion times for the 25, 50 or 75 mg·kg-1 FFM being, 42:21 ± 07:53, 40:55 ± 07:33 and 40:38 ± 07:20 min respectively, and 40:39 ± 07:51 min for the placebo. Likewise, average and peak power output did not significantly differ between trials (p = 0.06 and p = 0.46, respectively. Consequently, 500 kJ cycling TT performance was not different in any of the supplementation protocols in female cyclists.

  5. Single and combined effects of beetroot juice and caffeine supplementation on cycling time trial performance.

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    Lane, Stephen C; Hawley, John A; Desbrow, Ben; Jones, Andrew M; Blackwell, James R; Ross, Megan L; Zemski, Adam J; Burke, Louise M

    2014-09-01

    Both caffeine and beetroot juice have ergogenic effects on endurance cycling performance. We investigated whether there is an additive effect of these supplements on the performance of a cycling time trial (TT) simulating the 2012 London Olympic Games course. Twelve male and 12 female competitive cyclists each completed 4 experimental trials in a double-blind Latin square design. Trials were undertaken with a caffeinated gum (CAFF) (3 mg·kg(-1) body mass (BM), 40 min prior to the TT), concentrated beetroot juice supplementation (BJ) (8.4 mmol of nitrate (NO3(-)), 2 h prior to the TT), caffeine plus beetroot juice (CAFF+BJ), or a control (CONT). Subjects completed the TT (females: 29.35 km; males: 43.83 km) on a laboratory cycle ergometer under conditions of best practice nutrition: following a carbohydrate-rich pre-event meal, with the ingestion of a carbohydrate-electrolyte drink and regular oral carbohydrate contact during the TT. Compared with CONT, power output was significantly enhanced after CAFF+BJ and CAFF (3.0% and 3.9%, respectively, p caffeine (-0.9%, p = 0.4 compared with CAFF). We conclude that caffeine (3 mg·kg(-1) BM) administered in the form of a caffeinated gum increased cycling TT performance lasting ∼50-60 min by ∼3%-4% in both males and females. Beetroot juice supplementation was not ergogenic under the conditions of this study.

  6. Five-Kilometers Time Trial: Preliminary Validation of a Short Test for Cycling Performance Evaluation.

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    Dantas, Jose Luiz; Pereira, Gleber; Nakamura, Fabio Yuzo

    2015-09-01

    The five-kilometer time trial (TT5km) has been used to assess aerobic endurance performance without further investigation of its validity. This study aimed to perform a preliminary validation of the TT5km to rank well-trained cyclists based on aerobic endurance fitness and assess changes of the aerobic endurance performance. After the incremental test, 20 cyclists (age = 31.3 ± 7.9 years; body mass index = 22.7 ± 1.5 kg/m(2); maximal aerobic power = 360.5 ± 49.5 W) performed the TT5km twice, collecting performance (time to complete, absolute and relative power output, average speed) and physiological responses (heart rate and electromyography activity). The validation criteria were pacing strategy, absolute and relative reliability, validity, and sensitivity. Sensitivity index was obtained from the ratio between the smallest worthwhile change and typical error. The TT5km showed high absolute (coefficient of variation 0.95) reliability of performance variables, whereas it presented low reliability of physiological responses. The TT5km performance variables were highly correlated with the aerobic endurance indices obtained from incremental test (r > 0.70). These variables showed adequate sensitivity index (> 1). TT5km is a valid test to rank the aerobic endurance fitness of well-trained cyclists and to differentiate changes on aerobic endurance performance. Coaches can detect performance changes through either absolute (± 17.7 W) or relative power output (± 0.3 W.kg(-1)), the time to complete the test (± 13.4 s) and the average speed (± 1.0 km.h(-1)). Furthermore, TT5km performance can also be used to rank the athletes according to their aerobic endurance fitness.

  7. Ketone Diester Ingestion Impairs Time-Trial Performance in Professional Cyclists

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    Jill J. Leckey

    2017-10-01

    Full Text Available We investigated the effect of pre- “race” ingestion of a 1,3-butanediol acetoacetate diester on blood ketone concentration, substrate metabolism and performance of a cycling time trial (TT in professional cyclists. In a randomized cross-over design, 10 elite male cyclists completed a ~31 km laboratory-based TT on a cycling ergometer programmed to simulate the 2017 World Road Cycling Championships course. Cyclists consumed a standardized meal [2 g/kg body mass (BM carbohydrate (CHO] the evening prior to a trial day and a CHO breakfast (2 g/kg BM CHO with 200 mg caffeine on the morning of a trial day. Cyclists were randomized to consume either the ketone diester (2 × 250 mg/kg or a placebo drink, followed immediately by 200 mL diet cola, given ~ 30 min before and immediately prior to commencing a 20 min incremental warm-up. Blood samples were collected prior to and during the warm-up, pre- and post- TT and at regular intervals after the TT. Urine samples were collected pre- and post- warm-up, immediately post TT and 60 min post TT. Pre-exercise ingestion of the diester resulted in a 2 ± 1% impairment in TT performance that was associated with gut discomfort and higher perception of effort. Serum β-hydroxybutyrate, serum acetoacetate, and urine ketone concentrations increased from rest following ketone ingestion and were higher than placebo throughout the trial. Ketone ingestion induces hyperketonemia in elite professional cyclists when in a carbohydrate fed state, and impairs performance of a cycling TT lasting ~50 min.

  8. The effect of extrinsic motivation on cycle time trial performance

    NARCIS (Netherlands)

    Hulleman, M.; de Koning, J.J.; Hettinga, F.J.; Foster, C.

    2007-01-01

    PURPOSE: Athletes occasionally follow pacing patterns that seem unreasonably aggressive compared with those of prerace performances, potentially because of the motivation provided by competition. This study evaluated the effect of extrinsic motivation on cyclists' time trial performance. METHODS:

  9. The effect of extrinsic motivation on cycle time trial performance.

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    Hulleman, Michiel; De Koning, Jos J; Hettinga, Florentina J; Foster, Carl

    2007-04-01

    Athletes occasionally follow pacing patterns that seem unreasonably aggressive compared with those of prerace performances, potentially because of the motivation provided by competition. This study evaluated the effect of extrinsic motivation on cyclists' time trial performance. Well-trained recreational cyclists (N=7) completed four 1500-m laboratory time trials including a practice trial, two self-paced trials, and a trial where a monetary reward was offered. Time, total power output, power output attributable to aerobic and anaerobic metabolic sources, VO2, and HR were measured. The time required for the second, third, and last (extrinsically motivated) time trials was 133.1 +/- 2.1, 134.1 +/- 3.4, and 133.6 +/- 3.0 s, respectively, and was not different (P>0.05). There were no differences for total (396 +/- 19, 397 +/- 23, and 401 +/- 17 W), aerobic (253 +/- 12, 254 +/- 10, and 246 +/- 13 W), and anaerobic (143 +/- 14, 143 +/- 21, and 155 +/- 11 W) power output. The highest VO2 was not different over consecutive time trials (3.76 +/- 0.19, 3.73 +/- 0.16, and 3.71 +/- 0.22 L x min(-1)). When ranked by performance, without reference to the extrinsic motivation (131.9 +/- 2.4, 133.4 +/- 2.4, and 135.4 +/- 2.5 s), there was a significant difference for the first 100 m and from 100 to 300 m in power output, with a larger total power (560 +/- 102, 491 +/- 82, and 493 +/- 93; and 571 +/- 94, 513 +/- 41, and 484 +/- 88 W) and power attributable to anaerobic sources (446 +/- 100, 384 +/- 80, and 324 +/- 43; and 381 +/- 87, 383 +/- 90, and 289 +/- 91 W) for the fastest trial. Extrinsic motivation did not change the time trial performance, suggesting that 1500-m performance is extremely stable and not readily changeable with simple external motivation. The results suggest that spontaneous improvement in performance for time trials of this duration is attributable to greater early power output, which is primarily attributable to anaerobic metabolic sources.

  10. Case Study: Dose Response of Caffeine on 20-km Handcycling Time Trial Performance in a Paratriathlete.

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    Graham-Paulson, Terri; Perret, Claudio; Goosey-Tolfrey, Victoria

    2018-05-03

    Caffeine's (CAF) ability to influence upper-body exercise endurance performance may be related to an individual's training status. This case study therefore aimed to investigate the ergogenic effects of CAF dose on 20-km time trial (TT) performance of an elite male paratriathlete (wheelchair user; age = 46 years, body mass = 76.9 kg, body fat = 25.4%, and handcycling [Formula: see text]). The athlete completed four 20-km handcycling TTs on a Cyclus II ergometer under controlled laboratory conditions following the ingestion of 2, 4, and 6 mg/kg CAF or placebo (PLA). Blood lactate concentration, power output, arousal, and ratings of perceived exertion were recorded. Ingestion of 2, 4, and 6 mg/kg CAF resulted in a 2%, 1.5%, and 2.7% faster TT compared with PLA (37:40 min:s). The participant's blood lactate concentration increased throughout all trials and was greater during CAF compared with PLA. There were no obvious differences in ratings of perceived exertion between trials despite different performance times. Baseline arousal scores differed between PLA and 4 mg/kg CAF (1 = low), and 2 and 6 mg/kg CAF (3 = moderate). Arousal increased at each time point following the ingestion of 4 and 6 mg/kg CAF. The largest CAF dose resulted in a positive pacing strategy, which, when combined with an end spurt, resulted in the fastest TT. CAF improved 20-km TT performance of an elite male paratriathlete, which may be related to greater arousal and an increased power output for a given rating of perceived exertion.

  11. Improvements in Cycling but Not Handcycling 10 km Time Trial Performance in Habitual Caffeine Users.

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    Graham-Paulson, Terri; Perret, Claudio; Goosey-Tolfrey, Victoria

    2016-06-25

    Caffeine supplementation during whole-/lower-body exercise is well-researched, yet evidence of its effect during upper-body exercise is equivocal. The current study explored the effects of caffeine on cycling/handcycling 10 km time trial (TT) performance in habitual caffeine users. Eleven recreationally trained males (mean (SD) age 24 (4) years, body mass 85.1 (14.6) kg, cycling/handcycling peak oxygen uptake ( V · peak) 42.9 (7.3)/27.6 (5.1) mL∙kg∙min(-1), 160 (168) mg/day caffeine consumption) completed two maximal incremental tests and two familiarization sessions. During four subsequent visits, participants cycled/handcycled for 30 min at 65% mode-specific V · peak (preload) followed by a 10 km TT following the ingestion of 4 mg∙kg(-1) caffeine (CAF) or placebo (PLA). Caffeine significantly improved cycling (2.0 (2.0)%; 16:35 vs. 16:56 min; p = 0.033) but not handcycling (1.8 (3.0)%; 24:10 vs. 24:36 min; p = 0.153) TT performance compared to PLA. The improvement during cycling can be attributed to the increased power output during the first and last 2 km during CAF. Higher blood lactate concentration (Bla) was reported during CAF compared to PLA (p Caffeine improved cycling but not handcycling TT performance. The lack of improvement during handcycling may be due to the smaller active muscle mass, elevated (Bla) and/or participants' training status.

  12. Single and Combined Effects of Beetroot Crystals and Sodium Bicarbonate on 4-km Cycling Time Trial Performance.

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    Callahan, Marcus J; Parr, Evelyn B; Hawley, John A; Burke, Louise M

    2017-06-01

    When ingested alone, beetroot juice and sodium bicarbonate are ergogenic for high-intensity exercise performance. This study sought to determine the independent and combined effects of these supplements. Eight endurance trained (VO 2 max 65 mL·kg·min -1 ) male cyclists completed four × 4-km time trials (TT) in a doubleblind Latin square design supplementing with beetroot crystals (BC) for 3 days (15 g·day -1 + 15 g 1 h before TT, containing 300 mg nitrate per 15 g), bicarbonate (Bi 0.3 g·kg -1 body mass [BM] in 5 doses every 15 min from 2.5 h before TT); BC+Bi or placebo (PLA). Subjects completed TTs on a Velotron cycle ergometer under standardized laboratory conditions. Plasma nitrite concentrations were significantly elevated only in the BC+Bi trial before the TT (1520 ± 786 nmol·L -1 ) compared with baseline (665 ± 535 nmol·L -1 , p = .02) and the Bi and PLA conditions (Bi: 593 ± 203 nmol·L -1 , p .05). Blood bicarbonate concentrations were increased in the BC+Bi and Bi trials before the TT (BC+Bi: 30.9 ± 2.8 mmol·L -1 ; Bi: 31.7 ± 1.1 mmol·L -1 ). There were no differences in mean power output (386-394 W) or the time taken to complete the TT (335.8-338.1 s) between any conditions. Under the conditions of this study, supplementation was not ergogenic for 4-km TT performance.

  13. Acidosis, but Not Alkalosis, Affects Anaerobic Metabolism and Performance in a 4-km Time Trial.

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    Correia-Oliveira, Carlos Rafaell; Lopes-Silva, João Paulo; Bertuzzi, Romulo; McConell, Glenn K; Bishop, David John; Lima-Silva, Adriano Eduardo; Kiss, Maria Augusta Peduti Dal'molin

    2017-09-01

    This study aimed to determine the effect of preexercise metabolic acidosis and alkalosis on power output (PO) and aerobic and anaerobic energy expenditure during a 4-km cycling time trial (TT). Eleven recreationally trained cyclists (V˙O2peak 54.1 ± 9.3 mL·kg·min) performed a 4-km TT 100 min after ingesting in a double-blind matter 0.15 g·kg of body mass of ammonium chloride (NH4Cl, acidosis), 0.3 g·kg of sodium bicarbonate (NaHCO3, alkalosis), or 0.15 g·kg of CaCO3 (placebo). A preliminary study (n = 7) was conducted to establish the optimal doses to promote the desirable preexercise blood pH alterations without gastrointestinal distress. Data for PO, aerobic and anaerobic energy expenditure, and blood and respiratory parameters were averaged for each 1 km and compared between conditions using two-way repeated-measures ANOVA (condition and distance factors). Gastrointestinal discomfort was analyzed qualitatively. Compared with placebo (pH 7.37 ± 0.02, [HCO3]: 27.5 ± 2.6 mmol·L), the NaHCO3 ingestion resulted in a preexercise blood alkalosis (pH +0.06 ± 0.04, [HCO3]: +4.4 ± 2.0 mmol·L, P 0.05). Minimal gastrointestinal distress was noted in all conditions. Preexercise acidosis, but not alkalosis, affects anaerobic metabolism and PO during a 4-km cycling TT.

  14. Improvements in Cycling Time Trial Performance Are Not Sustained Following the Acute Provision of Challenging and Deceptive Feedback

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    Hollie S Jones

    2016-09-01

    Full Text Available TThe provision of performance-related feedback during exercise is acknowledged as an influential external cue used to inform pacing decisions. The provision of this feedback in a challenging or deceptive context allows research to explore how feedback can be used to improve performance and influence perceptual responses. However, the effects of deception on both acute and residual responses have yet to be explored, despite potential application for performance enhancement. Therefore, this study investigated the effects of challenging and deceptive feedback on perceptual responses and performance in self-paced cycling time trials (TT and explored whether changes in performance are sustained in a subsequent TT following the disclosure of the deception.Seventeen trained male cyclists were assigned to either an accurate or deceptive feedback group and performed four 16.1 km cycling TTs; 1 and 2 ride-alone baseline TTs where a fastest baseline (FBL performance was identified, 3 a TT against a virtual avatar representing 102% of their FBL performance (PACER, and 4 a subsequent ride-alone TT (SUB. The deception group, however, were initially informed that the avatar accurately represented their FBL, but prior to SUB were correctly informed of the nature of the avatar. Affect, self-efficacy and RPE were measured every quartile. Both groups performed PACER faster than FBL and SUB (p < 0.05 and experienced lower affect (p = 0.016, lower self-efficacy (p = 0.011, and higher RPE (p < 0.001 in PACER than FBL. No significant differences were found between FBL and SUB for any variable. The presence of the pacer rather than the manipulation of performance beliefs acutely facilitates TT performance and perceptual responses. Revealing that athletes’ performance beliefs were falsely negative due to deceptive feedback provision has no effect on subsequent perceptions or performance. A single experiential exposure may not be sufficient to produce meaningful

  15. Effect of time of day on performance, hormonal and metabolic response during a 1000-M cycling time trial.

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    Alan Lins Fernandes

    Full Text Available The aim of this study was to determine the effect of time of day on performance, pacing, and hormonal and metabolic responses during a 1000-m cycling time-trial. Nine male, recreational cyclists visited the laboratory four times. During the 1st visit the participants performed an incremental test and during the 2nd visit they performed a 1000-m cycling familiarization trial. On the 3rd and 4th visits, the participants performed a 1000-m TT at either 8 am or 6 pm, in randomized, repeated-measures, crossover design. The time to complete the time trial was lower in the evening than in the morning (88.2±8.7 versus 94.7±10.9 s, respectively, p0.05, but the norepinephrine response to the exercise was increased in the morning (+46%, p0.05. Our findings suggest that performance was improved in the evening, and it was accompanied by an improved hormonal and metabolic milieu.

  16. The Reliability and Validity of a Four-Minute Running Time-Trial in Assessing V˙O2max and Performance

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    Kerry McGawley

    2017-05-01

    Full Text Available Introduction: Traditional graded-exercise tests to volitional exhaustion (GXTs are limited by the need to establish starting workloads, stage durations, and step increments. Short-duration time-trials (TTs may be easier to implement and more ecologically valid in terms of real-world athletic events. The purpose of the current study was to assess the reliability and validity of maximal oxygen uptake (V˙O2max and performance measured during a traditional GXT (STEP and a four-minute running time-trial (RunTT.Methods: Ten recreational runners (age: 32 ± 7 years; body mass: 69 ± 10 kg completed five STEP tests with a verification phase (VER and five self-paced RunTTs on a treadmill. The order of the STEP/VER and RunTT trials was alternated and counter-balanced. Performance was measured as time to exhaustion (TTE for STEP and VER and distance covered for RunTT.Results: The coefficient of variation (CV for V˙O2max was similar between STEP, VER, and RunTT (1.9 ± 1.0, 2.2 ± 1.1, and 1.8 ± 0.8%, respectively, but varied for performance between the three types of test (4.5 ± 1.9, 9.7 ± 3.5, and 1.8 ± 0.7% for STEP, VER, and RunTT, respectively. Bland-Altman limits of agreement (bias ± 95% showed V˙O2max to be 1.6 ± 3.6 mL·kg−1·min−1 higher for STEP vs. RunTT. Peak HR was also significantly higher during STEP compared with RunTT (P = 0.019.Conclusion: A four-minute running time-trial appears to provide more reliable performance data in comparison to an incremental test to exhaustion, but may underestimate V˙O2max.

  17. Field-measured drag area is a key correlate of level cycling time trial performance

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    James E. Peterman

    2015-08-01

    Full Text Available Drag area (Ad is a primary factor determining aerodynamic resistance during level cycling and is therefore a key determinant of level time trial performance. However, Ad has traditionally been difficult to measure. Our purpose was to determine the value of adding field-measured Ad as a correlate of level cycling time trial performance. In the field, 19 male cyclists performed a level (22.1 km time trial. Separately, field-determined Ad and rolling resistance were calculated for subjects along with projected frontal area assessed directly (AP and indirectly (Est AP. Also, a graded exercise test was performed to determine $\\dot {V}{O}_{2}$V̇O2 peak, lactate threshold (LT, and economy. $\\dot {V}{O}_{2}$V̇O2 peak ($\\mathrm{l}~\\min ^{-1}$lmin−1 and power at LT were significantly correlated to power measured during the time trial (r = 0.83 and 0.69, respectively but were not significantly correlated to performance time (r = − 0.42 and −0.45. The correlation with performance time improved significantly (p < 0.05 when these variables were normalized to Ad. Of note, Ad alone was better correlated to performance time (r = 0.85, p < 0.001 than any combination of non-normalized physiological measure. The best correlate with performance time was field-measured power output during the time trial normalized to Ad (r = − 0.92. AP only accounted for 54% of the variability in Ad. Accordingly, the correlation to performance time was significantly lower using power normalized to AP (r = − 0.75 or Est AP (r = − 0.71. In conclusion, unless normalized to Ad, level time trial performance in the field was not highly correlated to common laboratory measures. Furthermore, our field-measured Ad is easy to determine and was the single best predictor of level time trial performance.

  18. Augmenting performance feedback does not affect 4 km cycling time-trials in the heat.

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    Waldron, Mark; Villerius, Vincent; Murphy, Aron

    2015-01-01

    We compared the effects of (1) accurate and (2) surreptitiously augmented performance feedback on power output and physiological responses to a 4000 m time-trial in the heat. Nine cyclists completed a baseline (BaseL) 4000 m time-trial in ambient temperatures of 30°C, followed by two further 4000 m time-trials at the same temperature, randomly assigning the participants to an accurate (ACC; accurate feedback of baseline) or deceived (DEC; 2% increase above baseline) feedback group. The total power output (PO) and aerobic (Paer) and anaerobic (Pan) contributions were determined at 0.4 km stages during the time-trials, alongside measurements of rectal (Trec) and skin (Tskin) temperatures. There were no differences (P > 0.05) in any of the variables between BaseL, ACC and DEC, despite increases (P 0.05) between feedback condition and time-trial stage. Providing surreptitiously augmented performance feedback to well-trained cyclists did not alter their performance or physiological responses to a 4000 m time-trial in a hot environment. The assumed influence of augmented performance feedback was nullified in the heat, perhaps reflecting a central down-regulation of exercise intensity in response to an increased body temperature.

  19. Effect of β-alanine supplementation on 20 km cycling time trial performance

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    Ruth Margaret JAMES

    2014-09-01

    Full Text Available The effects of β-alanine supplementation on high-intensity cycling performance and capacity have been evaluated, although the effects on longer duration cycling performance are unclear. Nineteen UK category 1 male cyclists completed four 20 km cycling time trials, two before and two after supplementation with either 6.4 g•d-1 β-alanine (n = 10; BA or a matched placebo (n = 9; P. Performance time for the 20 km time trial and 1 km split times were recorded. There was no significant effect of β-alanine supplementation on 20 km time trial performance (BA-pre 1943 ± 129 s; BA-post 1950 ± 147 s; P-pre 1989 ± 106 s; P-post 1986 ± 115 s or on the performance of each 1 km split. The effect of β-alanine on 20 km time trial performance was deemed unclear as determined by magnitude based inferences. Supplementation with 6.4 g•d-1 of β-alanine for 4 weeks did not affect 20 km cycling time trial performance in well trained male cyclists.

  20. Effect of inhaled terbutaline on substrate utilization and 300-kcal time trial performance

    DEFF Research Database (Denmark)

    Kalsen, Anders; Hostrup, Morten; Karlsson, Sebastian

    2014-01-01

    . There was no difference between PLA and TER in net muscle glycogen utilization and lactate accumulation during the time trial. IMTG did not change with treatment or exercise. PDH-E1α Ser(293) and Ser(300) phosphorylation were lower (P...In a randomized double-blind crossover design, we investigated the effect of the beta2-agonist terbutaline on endurance performance and substrate utilization in nine moderately trained males (maximum oxygen uptake (VO2max): 58.9±3.1 mL min(-1) kg(-1)). Subjects performed 60 min of submaximal...... exercise (65-70% of VO2max) immediately followed by a 300-kcal time trial with inhalation of either terbutaline (TER) or placebo (PLA). Pulmonary gas exchange was measured during the submaximal exercise and muscle biopsies were collected before and after the exercise bouts. Time trial performance...

  1. Physiological Correlations with Short, Medium, and Long Cycling Time-Trial Performance

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    Borszcz, Fernando K.; Tramontin, Artur F.; de Souza, Kristopher M.; Carminatti, Lorival J.; Costa, Vitor P.

    2018-01-01

    Purpose: Several studies have demonstrated that physiological variables predict cycling endurance performance. However, it is still unclear whether the predictors will change over different performance durations. The aim of this study was to assess the correlations between physiological variables and cycling time trials with different durations.…

  2. Effect of caffeine on cycling time-trial performance in the heat.

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    Pitchford, Nathan W; Fell, James W; Leveritt, Michael D; Desbrow, Ben; Shing, Cecilia M

    2014-07-01

    The purpose of this investigation was to determine whether a moderate dose of caffeine would improve a laboratory simulated cycling time-trial in the heat. Nine well-trained male subjects (VO2max 64.4±6.8mLmin(-1)kg(-1), peak power output 378±40W) completed one familiarisation and two experimental laboratory simulated cycling time-trials in environmental conditions of 35°C and 25% RH 90min after consuming either caffeine (3mgkg(-1) BW) or placebo, in a double blind, cross-over study. Time-trial performance was faster in the caffeine trial compared with the placebo trial (mean±SD, 3806±359s versus 4079±333s, p=0.06, 90%CI 42-500s, 86% likelihood of benefit, d=-0.79). Caffeine ingestion was associated with small to moderate increases in average heart rate (p=0.178, d=0.39), VO2 (p=0.154, d=0.45), respiratory exchange ratio (p=0.292, d=0.35) and core temperature (p=0.616, d=0.22) when compared to placebo, however, these were not statistically significant. Average RPE during the caffeine supplemented time-trial was not significantly different from placebo (p=0.41, d=-0.13). Caffeine supplementation at 3mgkg(-1) BW resulted in a worthwhile improvement in cycling time-trial performance in the heat. Double-blind cross-over study. Copyright © 2013 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  3. Caffeinated nitric oxide-releasing lozenge improves cycling time trial performance.

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    Lee, J; Kim, H T; Solares, G J; Kim, K; Ding, Z; Ivy, J L

    2015-02-01

    Boosting nitric oxide production during exercise by various means has been found to improve exercise performance. We investigated the effects of a nitric oxide releasing lozenge with added caffeine (70 mg) on oxygen consumption during steady-state exercise and cycling time trial performance using a double-blinded randomized, crossover experimental design. 15 moderately trained cyclists (7 females and 8 males) were randomly assigned to ingest the caffeinated nitric oxide lozenge or placebo 5 min before exercise. Oxygen consumption and blood lactate were assessed at rest and at 50%, 65% and 75% maximal oxygen consumption. Exercise performance was assessed by time to complete a simulated 20.15 km cycling time-trial course. No significant treatment effects for oxygen consumption or blood lactate at rest or during steady-state exercise were observed. However, time-trial performance was improved by 2.1% (p<0.01) when participants consumed the nitric oxide lozenge (2,424±69 s) compared to placebo (2,476±78 s) and without a significant difference in rating of perceived exertion. These results suggest that acute supplementation with a caffeinated nitric oxide releasing lozenge may be a practical and effective means of improving aerobic exercise performance. © Georg Thieme Verlag KG Stuttgart · New York.

  4. Beetroot Juice Improves On-Water 500 M Time-Trial Performance, and Laboratory-Based Paddling Economy in National and International-Level Kayak Athletes.

    Science.gov (United States)

    Peeling, Peter; Cox, Gregory R; Bullock, Nicola; Burke, Louise M

    2015-06-01

    We assessed the ingestion of a beetroot juice supplement (BR) on 4-min laboratory-based kayak performance in national level male (n = 6) athletes (Study A), and on 500 m on-water kayak time-trial (TT) performance in international level female (n = 5) athletes (Study B). In Study A, participants completed three laboratory-based sessions on a kayak ergometer, including a 7 × 4 min step test, and two 4 min maximal effort performance trials. Two and a half hours before the warm-up of each 4 min performance trial, athletes received either a 70 ml BR shot containing ~4.8 mmol of nitrate, or a placebo equivalent (BRPLA). The distance covered over the 4 min TT was not different between conditions; however, the average VO2 over the 4 min period was significantly lower in BR (p = .04), resulting in an improved exercise economy (p = .05). In Study B, participants completed two field-based 500 m TTs, separated by 4 days. Two hours before each trial, athletes received either two 70 ml BR shots containing ~9.6 mmol of nitrate, or a placebo equivalent (BRPLA). BR supplementation significantly enhanced TT performance by 1.7% (p = .01). Our results show that in national-level male kayak athletes, commercially available BR shots (70 ml) containing ~4.8 mmol of nitrate improved exercise economy during laboratory-based tasks predominantly reliant on the aerobic energy system. Furthermore, greater volumes of BR (140 ml; ~9.6 mmol nitrate) provided to international-level female kayak athletes resulted in enhancements to TT performance in the field.

  5. Mental Toughness Moderates Social Loafing in Cycle Time-Trial Performance

    Science.gov (United States)

    Haugen, Tommy; Reinboth, Michael; Hetlelid, Ken J.; Peters, Derek M.; Høigaard, Rune

    2016-01-01

    Purpose: The purpose of this study was to determine if mental toughness moderated the occurrence of social loafing in cycle time-trial performance. Method: Twenty-seven men (M[subscript age] = 17.7 years, SD = 0.6) completed the Sport Mental Toughness Questionnaire prior to completing a 1-min cycling trial under 2 conditions: once with individual…

  6. Mouth Rinsing with Maltodextrin Solutions Fails to Improve Time Trial Endurance Cycling Performance in Recreational Athletes

    Directory of Open Access Journals (Sweden)

    Tuğba Nilay Kulaksız

    2016-05-01

    Full Text Available The carbohydrate (CHO concentration of a mouth rinsing solution might influence the CHO sensing receptors in the mouth, with consequent activation of brain regions involved in reward, motivation and regulation of motor activity. The purpose of the present study was to examine the effects of maltodextrin mouth rinsing with different concentrations (3%, 6% and 12% after an overnight fast on a 20 km cycling time trial performance. Nine recreationally active, healthy males (age: 24 ± 2 years; V ˙ O 2 m a x : 47 ± 5 mL·kg−1·min−1 participated in this study. A double-blind, placebo-controlled randomized study was conducted. Participants mouth-rinsed every 2.5 km for 5 s. Maltodextrin mouth rinse with concentrations of 3%, 6% or 12% did not change time to complete the time trial and power output compared to placebo (p > 0.05. Time trial completion times were 40.2 ± 4.0, 40.1 ± 3.9, 40.1 ± 4.4, and 39.3 ± 4.2 min and power output 205 ± 22, 206 ± 25, 210 ± 24, and 205 ± 23 W for placebo, 3%, 6%, and 12% maltodextrin conditions, respectively. Heart rate, lactate, glucose, and rating of perceived exertion did not differ between trials (p > 0.05. In conclusion, mouth rinsing with different maltodextrin concentrations after an overnight fast did not affect the physiological responses and performance during a 20 km cycling time trial in recreationally active males.

  7. Impact of sodium citrate ingestion during recovery after dehydrating exercise on rehydration and subsequent 40-km cycling time-trial performance in the heat.

    Science.gov (United States)

    Suvi, Silva; Mooses, Martin; Timpmann, Saima; Medijainen, Luule; Narõškina, Daria; Unt, Eve; Ööpik, Vahur

    2018-01-11

    The purpose of this study was to assess the impact of sodium citrate (CIT) ingestion (600 mg·kg -1 ) during recovery from dehydrating cycling exercise (DE) on subsequent 40-km cycling performance in a warm environment (32 °C). Twenty male nonheat-acclimated endurance athletes exercised in the heat until 4% body mass (BM) loss occurred. After 16 h recovery with consumption of water ad libitum and prescribed diet (evening meal 20 kcal·kg -1 , breakfast 12 kcal·kg -1 ) supplemented in a double-blind, randomized, crossover manner with CIT or placebo (PLC), they performed 40-km time-trial (TT) on a cycle ergometer in a warm environment. During recovery greater increases in BM and plasma volume (PV) concomitant with greater water intake and retention occurred in the CIT trial compared with the PLC trial (p 0.05) in sweat loss, PV decrement, ratings of perceived exertion, or TT time (CIT 68.10 ± 3.28 min, PLC 68.11 ± 2.87 min). At the end of TT blood lactate concentration was higher (7.58 ± 2.44 mmol·L -1 vs 5.58 ± 1.32 mmol·L -1 ; p = 0.0002) and rectal temperature lower (39.54 ± 0.50 °C vs 39.65 ± 0.52 °C; p = 0.033) in the CIT trial than in the PLC trial. Compared with pre-DE time point, PV had decreased to a lower level in the PLC trial than in the CIT trial (p = 0.0001). In conclusion, CIT enhances rehydration after exercise-induced dehydration but has no impact on subsequent 40-km cycling TT performance in a warm uncompensable environment.

  8. Competitor presence reduces internal attentional focus and improves 16.1km cycling time trial performance.

    Science.gov (United States)

    Williams, Emily L; Jones, Hollie S; Andy Sparks, S; Marchant, David C; Midgley, Adrian W; Mc Naughton, Lars R

    2015-07-01

    Whilst the presence of a competitor has been found to improve performance, the mechanisms influencing the change in selected work rates during direct competition have been suggested but not specifically assessed. The aim was to investigate the physiological and psychological influences of a visual avatar competitor during a 16.1-km cycling time trial performance, using trained, competitive cyclists. Randomised cross-over design. Fifteen male cyclists completed four 16.1km cycling time trials on a cycle ergometer, performing two with a visual display of themselves as a simulated avatar (FAM and SELF), one with no visual display (DO), and one with themselves and an opponent as simulated avatars (COMP). Participants were informed the competitive avatar was a similar ability cyclist but it was actually a representation of their fastest previous performance. Increased performance times were evident during COMP (27.8±2.0min) compared to SELF (28.7±1.9min) and DO (28.4±2.3min). Greater power output, speed and heart rate were apparent during COMP trial than SELF (pperformance. Competitive cyclists performed significantly faster during a 16.1-km competitive trial than when performing maximally, without a competitor. The improvement in performance was elicited due to a greater external distraction, deterring perceived exertion. Copyright © 2014 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  9. Pre-Exercise Hyperhydration-Induced Bodyweight Gain Does Not Alter Prolonged Treadmill Running Time-Trial Performance in Warm Ambient Conditions

    Directory of Open Access Journals (Sweden)

    Eric D. B. Goulet

    2012-08-01

    Full Text Available This study compared the effect of pre-exercise hyperhydration (PEH and pre-exercise euhydration (PEE upon treadmill running time-trial (TT performance in the heat. Six highly trained runners or triathletes underwent two 18 km TT runs (~28 °C, 25%–30% RH on a motorized treadmill, in a randomized, crossover fashion, while being euhydrated or after hyperhydration with 26 mL/kg bodyweight (BW of a 130 mmol/L sodium solution. Subjects then ran four successive 4.5 km blocks alternating between 2.5 km at 1% and 2 km at 6% gradient, while drinking a total of 7 mL/kg BW of a 6% sports drink solution (Gatorade, USA. PEH increased BW by 1.00 ± 0.34 kg (P < 0.01 and, compared with PEE, reduced BW loss from 3.1% ± 0.3% (EUH to 1.4% ± 0.4% (HYP (P < 0.01 during exercise. Running TT time did not differ between groups (PEH: 85.6 ± 11.6 min; PEE: 85.3 ± 9.6 min, P = 0.82. Heart rate (5 ± 1 beats/min and rectal (0.3 ± 0.1 °C and body (0.2 ± 0.1 °C temperatures of PEE were higher than those of PEH (P < 0.05. There was no significant difference in abdominal discomfort and perceived exertion or heat stress between groups. Our results suggest that pre-exercise sodium-induced hyperhydration of a magnitude of 1 L does not alter 80–90 min running TT performance under warm conditions in highly-trained runners drinking ~500 mL sports drink during exercise.

  10. Effect of lactate supplementation and sodium bicarbonate on 40-km cycling time trial performance.

    Science.gov (United States)

    Northgraves, Matthew J; Peart, Daniel J; Jordan, Christian A; Vince, Rebecca V

    2014-01-01

    The use of nutritional supplements to improve sporting performance and increase training adaptations is commonplace among athletes and is an expanding market in terms of product choice and availability. The purpose of this study was to examine the effects of 2 ergogenic aids with extracellular blood buffering potential, namely sodium bicarbonate (NaHCO3) and a lactate supplement, during a 40-km cycling time trial. Seven recreationally active men (age, 22.3 ± 3.3 years; height, 182.5 ± 6.5 cm; body mass, 79.2 ± 6.3 kg) completed five 40-km cycling time trials, including a familiarization trial in a randomized, blind, double placebo-controlled design. Subjects ingested (a) 300 mg·kg-1 body mass NaHCO3 (BICARB), (b) 45 mg·kg-1 body mass sodium chloride (PL-BICARB) as the placebo for the NaHCO3 trial, (c) 1115 mg lactate (LACTATE), or (d) plain flour as the placebo for the lactate trial (PL-LACTATE) 60 minutes before exercise. There was no significant difference in performance between the 4 conditions (p > 0.05). Although NaHCO3 ingestion induced significant changes in all the acid-base variables (all p 0.05). Subjects in the LACTATE condition did have a significantly higher heart rate (p 0.05) than the other 3 conditions. Neither NaHCO3 nor lactate supplementation seem to improve 40-km cycling time trial performance. However, the potential benefits following LACTATE regarding perceived exertion require further research.

  11. The effect of music on 10-km cycle time-trial performance.

    Science.gov (United States)

    Hagen, Jana; Foster, Carl; Rodríguez-Marroyo, Jose; de Koning, Jos J; Mikat, Richard P; Hendrix, Charles R; Porcari, John P

    2013-01-01

    Music is widely used as an ergogenic aid in sport, but there is little evidence of its effectiveness during closed-loop athletic events. In order to determine the effectiveness of music as an ergogenic aid, well-trained and task-habituated cyclists performed 10-km cycle time trials either while listening to self-selected motivational music or with auditory input blocked. There were no statistically significant differences in performance time or physiological or psychological markers related to music (time-trial duration17.75 ± 2.10 vs 17.81 ± 2.06 min, mean power output 222 ± 66 vs 220 ± 65 W, peak heart rate184 ± 9 vs 183 ± 8 beats/min, peak blood lactate12.1 ± 2.6 vs 11.9 ± 2.1 mmol/L, and final rating of perceived exertion 8.4 ± 1.5 vs 8.5 ± 1.6). It is concluded that during exercise at competitive intensity, there is no meaningful effect of music on either performance or physiology.

  12. The effects of Red Bull energy drink compared with caffeine on cycling time-trial performance.

    Science.gov (United States)

    Quinlivan, Alannah; Irwin, Christopher; Grant, Gary D; Anoopkumar-Dukie, Sheilandra; Skinner, Tina; Leveritt, Michael; Desbrow, Ben

    2015-10-01

    This study investigated the ergogenic effects of a commercial energy drink (Red Bull) or an equivalent dose of anhydrous caffeine in comparison with a noncaffeinated control beverage on cycling performance. Eleven trained male cyclists (31.7 ± 5.9 y 82.3 ± 6.1 kg, VO2max = 60.3 ± 7.8 mL · kg-1 · min-1) participated in a double-blind, placebo-controlled, crossover-design study involving 3 experimental conditions. Participants were randomly administered Red Bull (9.4 mL/kg body mass [BM] containing 3 mg/kg BM caffeine), anhydrous caffeine (3 mg/kg BM given in capsule form), or a placebo 90 min before commencing a time trial equivalent to 1 h cycling at 75% peak power output. Carbohydrate and fluid volumes were matched across all trials. Performance improved by 109 ± 153 s (2.8%, P = .039) after Red Bull compared with placebo and by 120 ± 172 s (3.1%, P = .043) after caffeine compared with placebo. No significant difference (P > .05) in performance time was detected between Red Bull and caffeine treatments. There was no significant difference (P > .05) in mean heart rate or rating of perceived exertion among the 3 treatments. This study demonstrated that a moderate dose of caffeine consumed as either Red Bull or in anhydrous form enhanced cycling time-trial performance. The ergogenic benefits of Red Bull energy drink are therefore most likely due to the effects of caffeine, with the other ingredients not likely to offer additional benefit.

  13. Mental Toughness Moderates Social Loafing in Cycle Time-Trial Performance.

    Science.gov (United States)

    Haugen, Tommy; Reinboth, Michael; Hetlelid, Ken J; Peters, Derek M; Høigaard, Rune

    2016-09-01

    The purpose of this study was to determine if mental toughness moderated the occurrence of social loafing in cycle time-trial performance. Twenty-seven men (Mage = 17.7 years, SD = 0.6) completed the Sport Mental Toughness Questionnaire prior to completing a 1-min cycling trial under 2 conditions: once with individual performance identified, and once in a group with individual performance not identified. Using a median split of the mental toughness index, participants were divided into high and low mental toughness groups. Cycling distance was compared using a 2 (trial) × 2 (high-low mental toughness) analysis of variance. We hypothesized that mentally tough participants would perform equally well under both conditions (i.e., no indication of social loafing) compared with low mentally tough participants, who would perform less well when their individual performance was not identifiable (i.e., demonstrating the anticipated social loafing effect). The high mental toughness group demonstrated consistent performance across both conditions, while the low mental toughness group reduced their effort in the non-individually identifiable team condition. The results confirm that (a) clearly identifying individual effort/performance is an important situational variable that may impact team performance and (b) higher perceived mental toughness has the ability to negate the tendency to loaf.

  14. Effects of dietary nitrate, caffeine, and their combination on 20-km cycling time trial performance.

    Science.gov (United States)

    Glaister, Mark; Pattison, John R; Muniz-Pumares, Daniel; Patterson, Stephen D; Foley, Paul

    2015-01-01

    The aim of this study was to examine the acute supplementation effects of dietary nitrate, caffeine, and their combination on 20-km cycling time trial performance. Using a randomized, counterbalanced, double-blind Latin-square design, 14 competitive female cyclists (age: 31 ± 7 years; height: 1.69 ± 0.07 m; body mass: 61.6 ± 6.0 kg) completed four 20-km time trials on a racing bicycle fitted to a turbo trainer. Approximately 2.5 hours before each trial, subjects consumed a 70-ml dose of concentrated beetroot juice containing either 0.45 g of dietary nitrate or with the nitrate content removed (placebo). One hour before each trial, subjects consumed a capsule containing either 5 mg·kg of caffeine or maltodextrin (placebo). There was a significant effect of supplementation on power output (p = 0.001), with post hoc tests revealing higher power outputs in caffeine (205 ± 21 W) vs. nitrate (194 ± 22 W) and placebo (194 ± 25 W) trials only. Caffeine-induced improvements in power output corresponded with significantly higher measures of heart rate (caffeine: 166 ± 12 b·min vs. placebo: 159 ± 15 b·min; p = 0.02), blood lactate (caffeine: 6.54 ± 2.40 mmol·L vs. placebo: 4.50 ± 2.11 mmol·L; p caffeine: 0.95 ± 0.04 vs. placebo: 0.91 ± 0.05; p = 0.03). There were no effects (p ≥ 0.05) of supplementation on cycling cadence, rating of perceived exertion, (Equation is included in full-text article.), or integrated electromyographic activity. The results of this study support the well-established beneficial effects of caffeine supplementation on endurance performance. In contrast, acute supplementation with dietary nitrate seems to have no effect on endurance performance and adds nothing to the benefits afforded by caffeine supplementation.

  15. Sodium bicarbonate improves 4 km time trial cycling performance when individualised to time to peak blood bicarbonate in trained male cyclists.

    Science.gov (United States)

    Gough, Lewis A; Deb, Sanjoy K; Sparks, S Andy; McNaughton, Lars R

    2018-08-01

    The aim of this study was to investigate the effects of sodium bicarbonate (NaHCO 3 ) on 4 km cycling time trial (TT) performance when individualised to a predetermined time to peak blood bicarbonate (HCO 3 - ). Eleven male trained cyclists volunteered for this study (height 1.82 ± 0.80 m, body mass (BM) 86.4 ± 12.9 kg, age 32 ± 9 years, peak power output (PPO) 382 ± 22 W). Two trials were initially conducted to identify time to peak HCO 3 - following both 0.2 g . kg -1 BM (SBC2) and 0.3 g . kg -1 BM (SBC3) NaHCO 3 . Thereafter, on three separate occasions using a randomised, double-blind, crossover design, participants completed a 4 km TT following ingestion of either SBC2, SBC3, or a taste-matched placebo (PLA) containing 0.07 g . kg -1 BM sodium chloride (NaCl) at the predetermined individual time to peak HCO 3 - . Both SBC2 (-8.3 ± 3.5 s; p < 0.001, d = 0.64) and SBC3 (-8.6 ± 5.4 s; p = 0.003, d = 0.66) reduced the time to complete the 4 km TT, with no difference between SBC conditions (mean difference = 0.2 ± 0.2 s; p = 0.87, d = 0.02). These findings suggest trained cyclists may benefit from individualising NaHCO 3 ingestion to time to peak HCO 3 - to enhance 4 km TT performance.

  16. Haemoglobin mass and running time trial performance after recombinant human erythropoietin administration in trained men.

    Directory of Open Access Journals (Sweden)

    Jérôme Durussel

    Full Text Available UNLABELLED: Recombinant human erythropoietin (rHuEpo increases haemoglobin mass (Hb(mass and maximal oxygen uptake (v O(2 max. PURPOSE: This study defined the time course of changes in Hb(mass, v O(2 max as well as running time trial performance following 4 weeks of rHuEpo administration to determine whether the laboratory observations would translate into actual improvements in running performance in the field. METHODS: 19 trained men received rHuEpo injections of 50 IU•kg(-1 body mass every two days for 4 weeks. Hb(mass was determined weekly using the optimized carbon monoxide rebreathing method until 4 weeks after administration. v O(2 max and 3,000 m time trial performance were measured pre, post administration and at the end of the study. RESULTS: Relative to baseline, running performance significantly improved by ∼6% after administration (10:30±1:07 min:sec vs. 11:08±1:15 min:sec, p<0.001 and remained significantly enhanced by ∼3% 4 weeks after administration (10:46±1:13 min:sec, p<0.001, while v O(2 max was also significantly increased post administration (60.7±5.8 mL•min(-1•kg(-1 vs. 56.0±6.2 mL•min(-1•kg(-1, p<0.001 and remained significantly increased 4 weeks after rHuEpo (58.0±5.6 mL•min(-1•kg(-1, p = 0.021. Hb(mass was significantly increased at the end of administration compared to baseline (15.2±1.5 g•kg(-1 vs. 12.7±1.2 g•kg(-1, p<0.001. The rate of decrease in Hb(mass toward baseline values post rHuEpo was similar to that of the increase during administration (-0.53 g•kg(-1•wk(-1, 95% confidence interval (CI (-0.68, -0.38 vs. 0.54 g•kg(-1•wk(-1, CI (0.46, 0.63 but Hb(mass was still significantly elevated 4 weeks after administration compared to baseline (13.7±1.1 g•kg(-1, p<0.001. CONCLUSION: Running performance was improved following 4 weeks of rHuEpo and remained elevated 4 weeks after administration compared to baseline. These field performance effects coincided with r

  17. The Effect of 400 µg Inhaled Salbutamol on 3 km Time Trial Performance in a Low Humidity Environment

    Directory of Open Access Journals (Sweden)

    John Molphy, John W. Dickinson, Neil J. Chester, Mike Loosemore, Gregory Whyte

    2017-12-01

    Full Text Available The Objectives of the study were to investigate whether 400 µg inhaled salbutamol influences 3 km running time-trial performance and lung function in eucapnic voluntary hyperpnoea positive (EVH+ve and negative (EVH-ve individuals. Fourteen male participants (22.4 ± 1.6yrs; 76.4 ± 8.7kg; 1.80 ± 0.07 m; (7 EVH+ve; 7 EVH-ve were recruited following written informed consent. All participants undertook an EVH challenge to identify either EVH+ve (↓FEV1>10% or EVH-ve (↓FEV110% from baseline in FEV1 following any time-trial. Administration of 400µg inhaled salbutamol does not improve 3 km time-trial performance in either mild EVH+ve or EVH–ve individuals despite significantly increased HR and FEV1.

  18. tt: Treelet transform with Stata

    DEFF Research Database (Denmark)

    Gorst-Rasmussen, Anders

    of the variation in the original data. However, in contrast to PCA, TT produces sparse components. This can greatly simplify interpretation. We describe the tt Stata add-on for performing TT. The add-on includes a Mata implementation of the TT algorithm, alongside other functionality to aid the practical...

  19. Analysis of classical time-trial performance and technique-specific physiological determinants in elite female cross-country skiers

    Directory of Open Access Journals (Sweden)

    Øyvind Sandbakk

    2016-08-01

    Full Text Available The present study investigated the contribution of performance on uphill, flat, and downhill sections to overall performance in an international 10-km classical time-trial in elite female cross-country skiers, as well as the relationships between performance on snow and laboratory-measured physiological variables in the double poling (DP and diagonal (DIA techniques. Ten elite female cross-country skiers were continuously measured by a global positioning system device during an international 10-km cross-country skiing time-trial in the classical technique. One month prior to the race, all skiers performed a 5-min submaximal and 3-min self-paced performance test while roller skiing on a treadmill, both in the DP and DIA techniques. The time spent on uphill (r=0.98 and flat (r=0.91 sections of the race correlated most strongly with the overall 10-km performance (both p<0.05. Approximately 56% of the racing time was spent uphill, and stepwise multiple regression revealed that uphill time explained 95.5% of the variance in overall performance (p<0.001. Distance covered during the 3-min roller-skiing test and body-mass normalized peak oxygen uptake (VO2peak in both techniques showed the strongest correlations with overall time-trial performance (r=0.66-0.78, with DP capacity tending to have greatest impact on the flat and DIA capacity on uphill terrain (all p<0.05. Our present findings reveal that the time spent uphill most strongly determine classical time-trial performance, and that the major portion of the performance differences among elite female cross-country skiers can be explained by variations in technique-specific aerobic power.

  20. Maintenance of hyperglycaemia does not improve performance in a ...

    African Journals Online (AJOL)

    a glucose clamp, improves 100 km cycling time-trial (TT) performance. Design. .... each TT, subjects were permitted to ingest water ad libitum. statistical .... The effects of normal and glucose syrup work diets on the ... Fructose and glucose ...

  1. Minor amounts of plasma medium-chain fatty acids and no improved time trial performance after consuming lipids

    DEFF Research Database (Denmark)

    Vistisen, Bodil; Nybo, L.; Xu, Xuebing

    2003-01-01

    after consumption of specific structured triacylglycerol, consisting of a mixture of medium-chain fatty acids and long-chain fatty acids, to prevent the adverse effects observed by MCT (pure medium-chain fatty acids) regarding gastrointestinal distress. Seven well-trained subjects cycled 3 h at 55......% of maximum 02 uptake during which they ingested CHO or CHO plus specific structured triacylglycerols. Immediately after the constant-load cycling, the subjects performed a time trial of similar to50-min duration. Breath and blood samples were obtained regularly during the experiment. Fatty acid composition...... of plasma triacylglycerols, fatty acids, and phospholipids was determined. Performance was similar after administration of CHO plus specific structured triacylglycerol [medium-, long-, and medium-chain fatty acid (MLM)] compared with CHO (50.0 +/- 1.8 and 50.8 +/- 3.6 min, respectively). No plasma 8...

  2. Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes

    DEFF Research Database (Denmark)

    Jacobs, Robert Acton; Rasmussen, Peter; Siebenmann, Christoph

    2011-01-01

    Human endurance performance can be predicted from maximal oxygen consumption (VO(2max)), lactate threshold, and exercise efficiency. These physiologic parameters, however, are not wholly exclusive from one another and their interplay is complex. Accordingly, we sought to identify more specific me...

  3. The effect of skin temperature on performance during a 7.5-km cycling time trial

    NARCIS (Netherlands)

    Levels, K.; de Koning, J.J.; Foster Jr., C.C.; Daanen, H.A.M.

    2012-01-01

    Aerobic exercise performance is seriously compromised in the heat. Possibly, a high skin temperature causes a rating of perceived exertion (RPE)-mediated decrease in exercise intensity. The purpose of this study was to determine the effect of skin temperature on power output during a 7.5-km cycling

  4. Improved performance of polymer solar cells using PBDTT-F-TT:PC{sub 71}BM blend film as active layer

    Energy Technology Data Exchange (ETDEWEB)

    Zang, Yue; Gao, Xiumin, E-mail: oemt@hdu.edu.cn; Lu, Xinmiao; Xin, Qing; Lin, Jun; Zhao, Jufeng

    2016-07-15

    Highlights: • The PCE of PBDTT-F-TT-based PSCs was improved to 9.34% by morphology control and device engineering. • Effect of DIO additive on the BHJ morphology and charge transport was investigated. • Effect of device architecture on the performance was studied in depth by optical modeling. • A low-temperature processed interfacial layer was introduced for plastic substrates. - Abstract: A detailed study of high-efficiency polymer solar cells (PSCs) based on a low bandgap polymer PBDTT-F-TT and PC{sub 71}BM as the bulk heterojunction (BHJ) layer is carried out. By using 1,8-diiodooctane (DIO) as solvent additive to control the morphology of active layer and comparing different device architecture to optimize the optical field distribution, the power conversion efficiency (PCE) of the resulted devices can be reached as high as 9.34%. Comprehensive characterization and optical modeling of the resulting devices is performed to understand the effect of DIO and device geometry on photovoltaic performance. It was found that the addition of DIO can significantly improve the nanoscale morphology and increased electron mobility in the BHJ layer. The inverted device architecture was chosen because the results from optical modeling shows that it offers better optical field distribution and exciton generation profile. Based on these results, a low-temperature processed ZnO was finally introduced as an electron transport layer to facility the fabrication on flexible substrates and showed comparable performance with the device based on conventional ZnO interlayer prepared by sol-gel process.

  5. Precooling With Crushed Ice: As Effective as Heat Acclimation at Improving Cycling Time-Trial Performance in the Heat.

    Science.gov (United States)

    Zimmermann, Matthew; Landers, Grant; Wallman, Karen; Kent, Georgina

    2018-02-01

    This study compared the effects of precooling (ice ingestion) and heat-acclimation training on cycling time-trial (CTT) performance in the heat. Fifteen male cyclists/triathletes completed two 800-kJ CTTs in the heat, with a 12-d training program in between. Initially, all participants consumed 7 g/kg of water (22°C) in 30 min before completing an 800-kJ CTT in hot, humid conditions (pre-CTT) (35°C, 50% relative humidity [RH]). Participants were then split into 2 groups, with the precooling group (n = 7) training in thermoneutral conditions and then undergoing precooling with ice ingestion (7 g/kg, 1°C) prior to the final CTT (post-CTT) and the heat-acclimation group (n = 8) training in hot conditions (35°C, 50% RH) and consuming water (7 g/kg) prior to post-CTT. After training in both conditions, improvement in CTT time was deemed a likely positive benefit (precooling -166 ± 133 s, heat acclimation -105 ± 62 s), with this result being similar between conditions (d = 0.22, -0.68-1.08 90% confidence interval [CI]). Core temperature for post-CTT was lower in precooling than in heat acclimation from 20 min into the precooling period until the 100-kJ mark of the CTT (d > 0.98). Sweat onset occurred later in precooling (250 ± 100 s) than in heat acclimation (180 ± 80 s) for post-CTT (d = 0.65, -0.30-1.50 90% CI). Thermal sensation was lower at the end of the precooling period prior to post-CTT for the precooling trial than with heat acclimation (d = 1.24, 0.90-1.58 90% CI). Precooling with ice ingestion offers an alternative method of improving endurance-cycling performance in hot conditions if heat acclimation cannot be attained.

  6. Novel precooling strategy enhances time trial cycling in the heat.

    Science.gov (United States)

    Ross, Megan L R; Garvican, Laura A; Jeacocke, Nikki A; Laursen, Paul B; Abbiss, Chris R; Martin, David T; Burke, Louise M

    2011-01-01

    To develop and investigate the efficacy of a new precooling strategy combining external and internal techniques on the performance of a cycling time trial (TT) in a hot and humid environment. Eleven well-trained male cyclists undertook three trials of a laboratory-based cycling TT simulating the course characteristics of the Beijing Olympic Games event in a controlled hot and humid environment (32°C-35°C at 50%-60% relative humidity). The trials, separated by 3-7 d, were undertaken in a randomized crossover design and consisted of the following: 1) CON-no treatment apart from the ad libitum consumption of cold water (4°C), 2) STD COOL-whole-body immersion in cold (10°C) water for 10 min followed by wearing a cooling jacket, or 3) NEW COOL-combination of consumption of 14 g of ice slurry ("slushie") per kilogram body mass made from a commercial sports drink while applying iced towels. There was an observable effect on rectal temperature (T(rec)) before the commencement of the TT after both precooling techniques (STD COOL < NEW COOL < CON, P < 0.05), but pacing of the TT resulted in similar T(rec), HR, and RPE throughout the cycling protocol in all trials. NEW COOL was associated with a 3.0% increase in power (approximately 8 W) and a 1.3% improvement in performance time (approximately 1:06 min) compared with the CON trial, with the true likely effects ranging from a trivial to a large benefit. The effect of the STD COOL trial compared with the CON trial was "unclear." This new precooling strategy represents a practical and effective technique that could be used by athletes in preparation for endurance events undertaken in hot and humid conditions.

  7. Cycling Time Trial Performance 4 Hours After Glycogen-Lowering Exercise Is Similarly Enhanced by Recovery Nondairy Chocolate Beverages Versus Chocolate Milk.

    Science.gov (United States)

    Upshaw, Adam U; Wong, Tiffany S; Bandegan, Arash; Lemon, Peter W

    2016-02-01

    Postexercise chocolate milk ingestion has been shown to enhance both glycogen resynthesis and subsequent exercise performance. To assess whether nondairy chocolate beverage ingestion post-glycogen-lowering exercise can enhance 20-km cycling time trial performance 4 hr later, eight healthy trained male cyclists (21.8 ± 2.3y, VO2max = 61.2 ± 1.4 ml·kg-1·min-1; M ± SD) completed a series of intense cycling intervals designed to lower muscle glycogen (Jentjens & Jeukendrup, 2003) followed by 4 hr of recovery and a subsequent 20-km cycling time trial. During the first 2 hr of recovery, participants ingested chocolate dairy milk (DAIRYCHOC), chocolate soy beverage (SOYCHOC), chocolate hemp beverage (HEMPCHOC), low-fat dairy milk (MILK), or a low-energy artificially sweetened, flavored beverage (PLACEBO) at 30-min intervals in a double-blind, counterbalanced repeated-measures design. All drinks, except the PLACEBO (247 kJ) were isoenergetic (2,107 kJ), and all chocolate-flavored drinks provided 1-g CHO·kg body mass-1·h-1. Fluid intake across treatments was equalized (2,262 ± 148 ml) by ingesting appropriate quantities of water based on drink intake. The CHO:PRO ratio was 4:1, 1.5:1, 4:1, and 6:1 for DAIRYCHOC, MILK, SOYCHOC, and HEMPCHOC, respectively. One-way analysis of variance with repeated measures showed time trial performance (DAIRYCHOC = 34.58 ± 2.5 min, SOYCHOC = 34.83 ± 2.2 min, HEMPCHOC = 34.88 ± 1.1 min, MILK = 34.47 ± 1.7 min) was enhanced similarly vs PLACEBO (37.85 ± 2.1) for all treatments (p = .019) These data suggest that postexercise macronutrient and total energy intake are more important for same-day 20-km cycling time trial performance after glycogen-lowering exercise than protein type or protein-to-carbohydrate ratio.

  8. FLUID INGESTION STRATEGIES OF COMPETITIVE CYCLISTS DURING 40 KM TIME TRIAL COMPETITION

    Directory of Open Access Journals (Sweden)

    Karianne Backx

    2007-12-01

    Full Text Available Dear Editor-in- ChiefLoss of fluid during prolonged exercise has been purported to be a cause of fatigue (Below et al., 1995; Walsh et al., 1994, for example. A plethora of information regarding 'optimal' fluid replacement strategies exists; perhaps the most prominent of these in the public domain is the position stand on exercise and fluid replacement published by the American College of Sports Medicine (ACSM. It recommends that one should ingest fluid early and continually at regular intervals in an attempt to replace the volume of fluid lost through sweating or consume as much as can be tolerated (Covertino et al., 1996. Drinking practices associated with different types of endurance activity are not well documented and it may be possible that the guidelines based on empirical data derived from laboratory conditions lack the necessary ecological validity for performance in the field. To our knowledge, there are no data on fluid intake or body mass losses during high-intensity cycling time trials (TT outside of laboratory conditions; although a pilot study questionnaire used by El-Sayed et al., 1997 revealed that the volume ingested in pre-race preparation over a similar TT race distance (46 km ranged between 0.125-0.5 L. Therefore the aim of this investigation was to elucidate the fluid ingestion strategies of competitive cyclists during pre-race preparation and 40 km TT competition and the resultant body mass loss.Seventy-two competitive male cyclists ranging from Elite Category to Category 4 cyclists (according to British Cycling classification volunteered to participated in this investigation from two separate 40 km TT (n = 21 and n = 51, respectively. Mean (±SD body mass, height and age for all participants were 73.4 ± 7.5 kg, 1.77 ± 0.06 m, and 47 ± 13 years. All procedures were approved by the University's Research Ethics Committee and subjects completed informed consent prior to the start of the investigation.Both events were held

  9. tt: Treelet transform with Stata

    DEFF Research Database (Denmark)

    Gorst-Rasmussen, Anders

    2012-01-01

    for much of the variation in the original data. However, in contrast to principal component analysis, the treelet transform produces sparse components. This can greatly simplify interpretation. I describe the tt Stata add-on for performing the treelet transform. The add-on includes a Mata implementation...

  10. Study and Performance Analysis of TT- FPS Based on CAN Bus%基于CAN总线的TT-FPS调度算法研究及其性能分析

    Institute of Scientific and Technical Information of China (English)

    吕伟杰; 刘鲁源; 王毅新

    2006-01-01

    针对CAN总线中消息在固定优先级调度(FPS)算法下传输不可预知、低优先级消息容易被阻塞的问题,提出了一种基于时间触发机制的固定优先级调度(TT-FPS)算法,给出了最糟糕响应时间的计算方法.然后以纯电动汽车消息系统为例进行了TT-FPS的性能分析,验证了TT-FPS较FPS有更好的性能.

  11. Manipulating Carbohydrate Availability Between Twice-Daily Sessions of High-Intensity Interval Training Over 2 Weeks Improves Time-Trial Performance.

    Science.gov (United States)

    Cochran, Andrew J; Myslik, Frank; MacInnis, Martin J; Percival, Michael E; Bishop, David; Tarnopolsky, Mark A; Gibala, Martin J

    2015-10-01

    Commencing some training sessions with reduced carbohydrate (CHO) availability has been shown to enhance skeletal muscle adaptations, but the effect on exercise performance is less clear. We examined whether restricting CHO intake between twice daily sessions of high-intensity interval training (HIIT) augments improvements in exercise performance and mitochondrial content. Eighteen active but not highly trained subjects (peak oxygen uptake [VO2peak] = 44 ± 9 ml/kg/min), matched for age, sex, and fitness, were randomly allocated to two groups. On each of 6 days over 2 weeks, subjects completed two training sessions, each consisting of 5 × 4-min cycling intervals (60% of peak power), interspersed by 2 min of recovery. Subjects ingested either 195 g of CHO (HI-HI group: ~2.3 g/kg) or 17 g of CHO (HI-LO group: ~0.3 g/kg) during the 3-hr period between sessions. The training-induced improvement in 250-kJ time trial performance was greater (p = .02) in the HI-LO group (211 ± 66 W to 244 ± 75 W) compared with the HI-HI group (203 ± 53 W to 219 ± 60 W); however, the increases in mitochondrial content was similar between groups, as reflected by similar increases in citrate synthase maximal activity, citrate synthase protein content and cytochrome c oxidase subunit IV protein content (p > .05 for interaction terms). This is the first study to show that a short-term "train low, compete high" intervention can improve whole-body exercise capacity. Further research is needed to determine whether this type of manipulation can also enhance performance in highly-trained subjects.

  12. CAPSiTT

    DEFF Research Database (Denmark)

    Lebrun, F.; Aharonian, F.; Beckmann, V.

    2010-01-01

    Proposed in response to the ESA call for the third Medium size mission (M3), CAPSiTT is a small mission designed for a 3-year survey of the non-thermal high energy sky from an equatorial LEO orbit. With a large effective area and a very wide field of view, its single instrument, a silicon tracker...

  13. Improved performance of polymer solar cells using PBDTT-F-TT:PC_7_1BM blend film as active layer

    International Nuclear Information System (INIS)

    Zang, Yue; Gao, Xiumin; Lu, Xinmiao; Xin, Qing; Lin, Jun; Zhao, Jufeng

    2016-01-01

    Highlights: • The PCE of PBDTT-F-TT-based PSCs was improved to 9.34% by morphology control and device engineering. • Effect of DIO additive on the BHJ morphology and charge transport was investigated. • Effect of device architecture on the performance was studied in depth by optical modeling. • A low-temperature processed interfacial layer was introduced for plastic substrates. - Abstract: A detailed study of high-efficiency polymer solar cells (PSCs) based on a low bandgap polymer PBDTT-F-TT and PC_7_1BM as the bulk heterojunction (BHJ) layer is carried out. By using 1,8-diiodooctane (DIO) as solvent additive to control the morphology of active layer and comparing different device architecture to optimize the optical field distribution, the power conversion efficiency (PCE) of the resulted devices can be reached as high as 9.34%. Comprehensive characterization and optical modeling of the resulting devices is performed to understand the effect of DIO and device geometry on photovoltaic performance. It was found that the addition of DIO can significantly improve the nanoscale morphology and increased electron mobility in the BHJ layer. The inverted device architecture was chosen because the results from optical modeling shows that it offers better optical field distribution and exciton generation profile. Based on these results, a low-temperature processed ZnO was finally introduced as an electron transport layer to facility the fabrication on flexible substrates and showed comparable performance with the device based on conventional ZnO interlayer prepared by sol-gel process.

  14. Positive Pacing Strategies Are Utilized by Elite Male and Female Para-cyclists in Short Time Trials in the Velodrome.

    Science.gov (United States)

    Wright, Rachel L

    2015-01-01

    In para-cycling, competitors are classed based on functional impairment resulting in cyclists with neurological and locomotor impairments competing against each other. In Paralympic competition, classes are combined by using a factoring adjustment to race times to produce the overall medallists. Pacing in short-duration track cycling events is proposed to utilize an "all-out" strategy in able-bodied competition. However, pacing in para-cycling may vary depending on the level of impairment. Analysis of the pacing strategies employed by different classification groups may offer scope for optimal performance; therefore, this study investigated the pacing strategy adopted during the 1-km time trial (TT) and 500-m TT in elite C1 to C3 para-cyclists and able-bodied cyclists. Total times and intermediate split times (125-m intervals; measured to 0.001 s) were obtained from the C1-C3 men's 1-km TT (n = 28) and women's 500-m TT (n = 9) from the 2012 Paralympic Games and the men's 1-km TT (n = 19) and women's 500-m TT (n = 12) from the 2013 UCI World Track Championships from publically available video. Split times were expressed as actual time, factored time (for the para-cyclists) and as a percentage of total time. A two-way analysis of variance was used to investigate differences in split times between the different classifications and the able-bodied cyclists in the men's 1-km TT and between the para-cyclists and able-bodied cyclists in the women's 500-m TT. The importance of position at the first split was investigated with Kendall's Tau-b correlation. The first 125-m split time was the slowest for all cyclists, representing the acceleration phase from a standing start. C2 cyclists were slowest at this 125-m split, probably due to a combination of remaining seated in this acceleration phase and a high proportion of cyclists in this group being trans-femoral amputees. Not all cyclists used aero-bars, preferring to use drop, flat or bullhorn handlebars. Split times

  15. Positive pacing strategies are utilised by elite male and female para-cyclists in short time trials in the velodrome

    Directory of Open Access Journals (Sweden)

    Rachel Lindsey Wright

    2016-01-01

    Full Text Available In para-cycling, competitors are classed based on functional impairment resulting in cyclists with neurological and locomotor impairments competing against each other. In Paralympic competition, classes are combined by using a factoring adjustment to race times to produce the overall medallists. Pacing in short-duration track cycling events is proposed to utilise an all-out strategy in able-bodied competition. However, pacing in para-cycling may vary depending on the level of impairment. Analysis of the pacing strategies employed by different classification groups may offer scope for optimal performance; therefore, this study investigated the pacing strategy adopted during the 1-km time trial (TT and 500-m TT in elite C1 to C3 para-cyclists and able-bodied cyclists. Total times and intermediate split times (125-m intervals; measured to 0.001s were obtained from the C1-C3 men’s 1-km TT (n=28 and women’s 500-m TT (n=9 from the 2012 Paralympic Games and the men’s 1-km TT (n=19 and women’s 500-m TT (n=12 from the 2013 UCI World Track Championships from publically available video. Split times were expressed as actual time, factored time (for the para-cyclists and as a percentage of total time. A two-way analysis of variance was used to investigate differences in split times between the different classifications and the able-bodied cyclists in the men’s 1-km TT and between the para-cyclists and able-bodied cyclists in the women’s 500-m TT. The importance of position at the first split was investigated with Kendall’s Tau-b correlation. The first 125-m split time was the slowest for all cyclists, representing the acceleration phase from a standing start. C2 cyclists were slowest at this 125-m split, probably due to a combination of remaining seated in this acceleration phase and a high proportion of cyclists in this group being trans-femoral amputees. Not all cyclists used aero-bars, preferring to use drop, flat or bullhorn handlebars

  16. A scientific nutrition strategy improves time trial performance by ≈6% when compared with a self-chosen nutrition strategy in trained cyclists: a randomized cross-over study.

    Science.gov (United States)

    Hottenrott, Kuno; Hass, Erik; Kraus, Manon; Neumann, Georg; Steiner, Martin; Knechtle, Beat

    2012-08-01

    We investigated whether an athlete's self-chosen nutrition strategy (A), compared with a scientifically determined one (S), led to an improved endurance performance in a laboratory time trial after an endurance exercise. S consisted of about 1000 mL·h(-1) fluid, in portions of 250 mL every 15 min, 0.5 g sodium·L(-1), 60 g glucose·h(-1), 30 g fructose·h(-1), and 5 mg caffeine·kg body mass(-1). Eighteen endurance-trained cyclists (16 male; 2 female) were tested using a randomized crossover-design at intervals of 2 weeks, following either A or S. After a warm-up, a maximal oxygen uptake test was performed. Following a 30-min break, a 2.5-h endurance exercise on a bicycle ergometer was carried out at 70% maximal oxygen uptake. After 5 min of rest, a time trial of 64.37 km (40 miles) was completed. The ingested nutrition was recorded every 15 min. In S, the athletes completed the time trial faster (128 vs. 136 min; p ≤ 0.001) and with a significantly higher power output (212 vs. 184 W; p ≤ 0.001). The intake of fluid, energy (carbohydrate-, mono-, and disaccharide), and sodium was significantly higher in S compared with A (p ≤ 0.001) during the endurance exercise. In the time trial, only sodium intake was significantly higher in S (p ≤ 0.001). We concluded that a time trial performance after a 2.5-h endurance exercise in a laboratory setting was significantly improved following a scientific nutrition strategy.

  17. Time Trials Versus Time-to-Exhaustion Tests: Effects on Critical Power, W', and Oxygen-Uptake Kinetics.

    Science.gov (United States)

    Karsten, Bettina; Baker, Jonathan; Naclerio, Fernando; Klose, Andreas; Bianco, Antonino; Nimmerichter, Alfred

    2018-02-01

    To investigate single-day time-to-exhaustion (TTE) and time-trial (TT) -based laboratory tests values of critical power (CP), W prime (W'), and respective oxygen-uptake-kinetic responses. Twelve cyclists performed a maximal ramp test followed by 3 TTE and 3 TT efforts interspersed by 60 min recovery between efforts. Oxygen uptake ( V ˙ O 2 ) was measured during all trials. The mean response time was calculated as a description of the overall [Formula: see text]-kinetic response from the onset to 2 min of exercise. TTE-determined CP was 279 ± 52 W, and TT-determined CP was 276 ± 50 W (P = .237). Values of W' were 14.3 ± 3.4 kJ (TTE W') and 16.5 ± 4.2 kJ (TT W') (P = .028). While a high level of agreement (-12 to 17 W) and a low prediction error of 2.7% were established for CP, for W' limits of agreements were markedly lower (-8 to 3.7 kJ), with a prediction error of 18.8%. The mean standard error for TTE CP values was significantly higher than that for TT CP values (2.4% ± 1.9% vs 1.2% ± 0.7% W). The standard errors for TTE W' and TT W' were 11.2% ± 8.1% and 5.6% ± 3.6%, respectively. The [Formula: see text] response was significantly faster during TT (~22 s) than TTE (~28 s). The TT protocol with a 60-min recovery period offers a valid, time-saving, and less error-filled alternative to conventional and more recent testing methods. Results, however, cannot be transferred to W'.

  18. Optics Measurements and Matching of TT2-TT10 Line for Injection of the LHC Beam in the SPS

    CERN Document Server

    Benedetto, E

    2008-01-01

    A well matched injection in the SPS is very important for preserving the emittance of the LHC beam. The paper presents the algorithms used for the analysis and the results of the 2007 optics measurements campaign done in the transfer line TT2-TT10 and in the SPS. The dispersion is computed by varying the beam momentum and recording the offsets at the BPMs, while the Twiss parameters and emittance measurements in TT2-TT10 are performed with beam profile monitors equipped with OTR screens. Finally, on the basis of such measurements, a betatron and dispersion matching of TT2-TT10 for injection in the SPS has been performed and successfully put in operation since October 2007.

  19. VeloTT tracking for LHCb Run II

    CERN Document Server

    Bowen, Espen Eie; Tresch, Marco

    2016-01-01

    This note describes track reconstruction in the LHCb tracking system upstream of the magnet, combining VELO tracks with hits in the TT sub-detector. The implementation of the VeloTT algorithm and its performance in terms of track reconstruction efficiency, ghost rate and execution time are presented. The algorithm has been rewritten for use in the first software trigger level for LHCb Run II. The momentum and charge information obtained for the VeloTT tracks (due to a fringe magnetic field between the VELO and TT sub-detectors) can reduce the total execution time for the full tracking sequence.

  20. Effect of task familiarisation on distribution of energy during a 2000 m cycling time trial.

    Science.gov (United States)

    Corbett, J; Barwood, M J; Parkhouse, K

    2009-10-01

    To investigate the effect of task familiarisation on the spontaneous pattern of energy expenditure during a series of 2000 m cycling time trials (TTs). Nine trained males completed three 2000 m TTs on a Velotron cycling ergometer. To examine pacing strategy, the data were assigned to 250 m "bins," with the pattern of aerobic and anaerobic energy expenditure calculated from total work accomplished and gas-exchange data. There were no significant differences between trials in performance times (191.4 (SD 4.3), 189.4 (4.6), 190.1 (5.6) s), total aerobic (58.3 (2.7), 58.4 (3.1), 58.0 (3.4) kJ) and total anaerobic energy expenditure (16.4 (3.3), 17.3 (2.8), 16.5 (3.1) kJ). Pacing strategy in the second and third TT differed from the first TT in that a lower power output was adopted during the first 500 m, enabling a higher power output during the final 750 m of the TT. This adjustment in the pattern of energy expenditure was mediated by an alteration in the pattern of anaerobic energy expenditure, which paralleled changes in total energy expenditure. Furthermore, participants retained an anaerobic energy "reserve" enabling an end-spurt during the second and third trials. Small modifications to the pacing strategy are made following a single bout of exercise, primarily by altering the rate of anaerobic energy expenditure. This may have served to prevent critical metabolic disturbances. The alteration in pacing strategy following the first exercise bout is compatible with a complex intelligent regulatory system.

  1. High-intensity interval training improves VO2peak, maximal lactate accumulation, time trial and competition performance in 9?11-year-old swimmers

    OpenAIRE

    Sperlich, Billy; Zinner, Christoph; Heilemann, Ilka; Kjendlie, Per-Ludvik; Holmberg, Hans-Christer; Mester, Joachim

    2010-01-01

    Training volume in swimming is usually very high when compared to the relatively short competition time. High-intensity interval training (HIIT) has been demonstrated to improve performance in a relatively short training period. The main purpose of the present study was to examine the effects of a 5-week HIIT versus high-volume training (HVT) in 9?11-year-old swimmers on competition performance, 100 and 2,000?m time (T 100?m and T 2,000?m), VO2peak and rate of maximal lactate accumulation (La...

  2. High intensity interval training improves VO2peak, maximal lactate production, time trial and competition performance in 9-11 year old swimmers

    OpenAIRE

    Sperlich, Billy; Zinner, Christoph; Helleman, Ilka; Kjendlie, Per-Ludvik; Holmberg, H. C.; Mester, Joachim

    2010-01-01

    Open Access - This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited. Training volume in swimming is usually very high when compared to the relatively short competition time. High-intensity interval training (HIIT) has been demonstrated to improve performance in a relatively short training period. The main purpose of the present s...

  3. The effect of carbohydrate mouth rinse on performance, biochemical and psychophysiological variables during a cycling time trial: a crossover randomized trial.

    Science.gov (United States)

    Ferreira, Amanda M J; Farias-Junior, Luiz F; Mota, Thaynan A A; Elsangedy, Hassan M; Marcadenti, Aline; Lemos, Telma M A M; Okano, Alexandre H; Fayh, Ana P T

    2018-01-01

    The hypothesis of the central effect of carbohydrate mouth rinse (CMR) on performance improvement in a fed state has not been established, and its psychophysiological responses have not yet been described. The aim of this study was to evaluate the effect of CMR in athletes fed state on performance, biochemical and psychophysiological responses compared to ad libitum water intake. Eleven trained male cyclists completed a randomized, crossover trial, which consisted of a 30 km cycle ergometer at self-selected intensity and in a fed state. Subjects were under random influence of the following interventions: CMR with a 6% unflavored maltodextrin solution; mouth rinsing with a placebo solution (PMR); drinking "ad libitum" (DAL). The time for completion of the test (min), heart rate (bpm) and power (watts), rating of perceived exertion (RPE), affective response, blood glucose (mg/dL) and lactate (mmol/DL), were evaluated before, during and immediately after the test, while insulin (uIL/mL), cortisol (μg/dL) and creatine kinase (U/L) levels were measured before, immediately after the test and 30 min after the test. Time for completion of the 30 km trial did not differ significantly among CMR, PMR and DAL interventions (means = 54.5 ± 2.9, 54.7 ± 2.9 and 54.5 ± 2.5 min, respectively; p  = 0.82). RPE and affective response were higher in DAL intervention ( p  creatine kinase responses showed no significant difference among interventions. In a fed state, CMR has not caused metabolic changes, and it has not improved physical performance compared to ad libitum water intake, but demonstrated a possible central effect. ReBec registration number: RBR-4vpwkg. Available in http://www.ensaiosclinicos.gov.br/rg/?q=RBR-4vpwkg.

  4. Racing an Opponent Alters Pacing, Performance and Muscle Force Decline, But Not RPE

    NARCIS (Netherlands)

    Konings, Marco J; Parkinson, Jordan; Zijdewind, Inge; Hettinga, Florentina

    PURPOSE: Performing against a virtual opponent has been shown to invite a change in pacing and improve time trial (TT) performance. This study explored how this performance improvement is established by assessing changes in pacing, neuromuscular function and perceived exertion. METHODS: After a peak

  5. Effect of recovery interventions on cycling performance and pacing strategy in the heat.

    Science.gov (United States)

    De Pauw, Kevin; Roelands, Bart; Vanparijs, Jef; Meeusen, Romain

    2014-03-01

    To determine the effect of active recovery (AR), passive rest (PR), and cold-water immersion (CWI) after 90 min of intensive cycling on a subsequent 12-min time trial (TT2) and the applied pacing strategy in TT2. After a maximal test and familiarization trial, 9 trained male subjects (age 22 ± 3 y, VO2max 62.1 ± 5.3 mL · min-1 · kg-1) performed 3 experimental trials in the heat (30°C). Each trial consisted of 2 exercise tasks separated by 1 h. The first was a 60-min constant-load trial at 55% of the maximal power output followed by a 30-min time trial (TT1). The second comprised a 12-min simulated time trial (TT2). After TT1, AR, PR, or CWI was applied for 15 min. No significant TT2 performance differences were observed, but a 1-sample t test (within each condition) revealed different pacing strategies during TT2. CWI resulted in an even pacing strategy, while AR and PR resulted in a gradual decline of power output after the onset of TT2 (P ≤ .046). During recovery, AR and CWI showed a trend toward faster blood lactate ([BLa]) removal, but during TT2 significantly higher [BLa] was only observed after CWI compared with PR (P = .011). The pacing strategy during subsequent cycling performance in the heat is influenced by the application of different postexercise recovery interventions. Although power was not significantly altered between groups, CWI enabled a differently shaped power profile, likely due to decreased thermal strain.

  6. Optics Measurements and Matching of TT2-TT10 Line for Injection of the LHC Beam in the SPS

    CERN Document Server

    Benedetto, E; Guerrero, A; Jacquet, D

    2008-01-01

    A well matched injection in the SPS is very important for preserving the emittance of the LHC beam. The paper presents the algorithms used for the analysis and the results of the optics measurements done in the transfer line TT2-TT10 and in the SPS. The dispersion is computed by varying the beam momentum and recording the offsets at the BPMs, while the Twiss parameters and emittance measurements in TT2-TT10 are performed with beam profile monitors equipped with OTR screens. These results are completed by those obtained with a matching monitor installed in the SPS as a prototype for the LHC. This device makes use of an OTR screen and a fast acquisition system, to get the turn by turn beam profiles right at injection in the ring, from which the beam mismatch is computed and compared with the results obtained in the line. Finally, on the basis of such measurements, a betatron and dispersion matching of TT2-TT10 for injection in the SPS has been performed and successfully put in operation.

  7. Experimental study of the test module of the electromagnetic end-cap calorimeter for the ATLAS experiment. Study of the spin correlation in the production of pairs tt-bar; Etude experimentale des performances du module 0 du calorimetre electromagnetique bouchon d'ATLAS. Etude de la correlation de spin dans la production des paires tt-bar au LHC

    Energy Technology Data Exchange (ETDEWEB)

    Hinz, L

    2001-06-01

    LHC, the future CERN proton collider, will start in 2006. It will be devoted to a better understanding of the Standard Model and new physics research. With a 10 {integral}b{sup -1} per year at low luminosity during the first three years, then 100 {integral}b{sup -1} per year, and energy of 14 TeV in the center of mass, the LHC is designed to discover the Standard or SUSY Higgs boson, or probe signature of new physics. ATLAS, one of the four experiments at the LHC, can study a large physics range, as Higgs boson, top and bottom, gauge bosons and new particles expected by SUSY model or other models beyond the Standard Model. The CPPM laboratory is responsible of a part of the electromagnetic end-cap calorimeter for the ATLAS experiment. In 1999, an ATLAS-like prototype of module was stacked in Marseille and intensively tested at CERN. Description of the calorimeter and a part of test-beam results are presented in this PhD manuscript. In parallel, a study about potentiality of the tt-bar spin correlation measurement was done. The high tt-bar statistic produced at the LHC allows to explore the quark top properties in details and being sensitive to new physics phenomena. Signatures of such physics can be extracted from tt-bar decay product angular distributions which are sensitive to tt-bar spin correlation. (authors)

  8. Effects of differentiated music on cycling time trial.

    Science.gov (United States)

    Lim, H B T; Atkinson, G; Karageorghis, C I; Eubank, M R; Eubank, M M

    2009-06-01

    The aim of this study was to investigate the effects of music introduced and removed during a 10-km cycling time trial with reference to Rejeski's parallel processing theory and Karageorghis, Terry and Lane's conceptual framework for the prediction of responses to asynchronous music during sub-maximal exercise. A range of performance variables, ratings of perceived exertion, positive affect, negative affect, and blood lactate were assessed. Eleven males (mean age=24.9, s=6.1 years) completed a 10-km time trial under three conditions; no music, music played initially then removed between 5-10 km, and music played between 5-10 km only. Variables of time, power, cadence, speed, RPE, blood lactate, positive and negative affect were analysed using a ConditionxDistance ANOVA. There was no significant main effect for music conditions for the performance variables, perceived exertion, blood lactate, and affect (p>0.05). Nevertheless, a significant interaction effect for ConditionxDistance was found for cycling speed, with participants cycling 1-1.25 km/h faster at the start of the music introduced time trial than in both the music removed and no music time trials (pmusic during exercise and this finding can be used to extend current theory as it does not specifically address the periodic use music. The fact that participants exercised harder when they expected music to be introduced at a later stage illustrates the behavioural influences that music can engender during self-paced exercise.

  9. Performance Assessment of Hazardous Air Pollutant (HAP)Free Chemical Paint Strippers on Military Coatings for Validation to Federal Specification TT-R-2918A

    Science.gov (United States)

    2016-03-01

    ARL-TN-0742 ● MAR 2016 US Army Research Laboratory Performance Assessment of Hazardous Air Pollutant (HAP)–Free Chemical Paint...the originator. ARL-TN-0742 ● MAR 2016 US Army Research Laboratory Performance Assessment of Hazardous Air Pollutant (HAP...COVERED (From - To) 1–30 April 2014 4. TITLE AND SUBTITLE Performance Assessment of Hazardous Air Pollutant (HAP)–Free Chemical Paint Strippers

  10. Temporary impact of blood donation on physical performance and hematologic variables in women

    DEFF Research Database (Denmark)

    Stangerup, Ida; Kramp, Nana L.; Ziegler, Andreas K.

    2017-01-01

    BACKGROUNDNo former studies have examined how blood donation influences physical performance in women, who due to menstruation may have a slower recovery of performance. Therefore, the aim of this study was to clarify how VO2peak, time trial (TT) performance, and hematologic variables are affected...... in 18 iron-sufficient (plasma ferritin [P-ferritin] > 30 µg/L) women after a standard 450-mL blood donation. STUDY DESIGN AND METHODSVO2peak, TT performance, and blood variables were measured at baseline and 3, 7, 14, 21, and 28 days after blood donation in 18 iron-sufficient women. Anthropometrics were...

  11. Effects of music on work-rate distribution during a cycling time trial.

    Science.gov (United States)

    Atkinson, G; Wilson, D; Eubank, M

    2004-11-01

    Previous research work on the ergogenic effects of music has mainly involved constant power tests to exhaustion as dependent variables. Time trials are more externally valid than constant power tests, may be more reliable and allow the distribution of self-selected work-rate to be explored. We examined whether music improved starting, finishing and/or overall power during a 10-km cycling time trial, and whether heart rate and subjective responses to this time trial were altered by music. Sixteen participants performed two 10-km time trials on a Cybex cycle ergometer with, and without, the presence of a form of dance music known as "trance" (tempo = 142 beats x min (-1), volume at ear = 87 dB). Participants also completed the Brunel music rating inventory (BMRI) after each time trial in the music condition. The mean +/- SD time to complete the time trial was 1030 +/- 79 s in the music condition compared to 1052 +/- 77 s without music (95 % CI of difference = 10 to 34 s, p = 0.001). Nevertheless, ratings of perceived exertion were consistently (0.8 units) higher throughout the time trial with music (p music-induced increases in cycling speed and heart rate were observed in the first 3 km of the time trial. After completion of the BMRI, participants rated the "tempo" and "rhythm" of the music as more motivating than the "harmony" and "melody" aspects. These results suggest that music improves cycling speed mostly in the first few minutes of a 10-km time trial. In contrast to the findings of previous research, which suggested that music lowers perceived exertion at a constant work-rate, the participants in our time trials selected higher work-rates with music, whilst at the same time perceived these work-rates as being harder than without music.

  12. Effect of different protocols of caffeine intake on metabolism and endurance performance.

    Science.gov (United States)

    Cox, Gregory R; Desbrow, Ben; Montgomery, Paul G; Anderson, Megan E; Bruce, Clinton R; Macrides, Theodore A; Martin, David T; Moquin, Angela; Roberts, Alan; Hawley, John A; Burke, Louise M

    2002-09-01

    Competitive athletes completed two studies of 2-h steady-state (SS) cycling at 70% peak O(2) uptake followed by 7 kJ/kg time trial (TT) with carbohydrate (CHO) intake before (2 g/kg) and during (6% CHO drink) exercise. In Study A, 12 subjects received either 6 mg/kg caffeine 1 h preexercise (Precaf), 6 x 1 mg/kg caffeine every 20 min throughout SS (Durcaf), 2 x 5 ml/kg Coca-Cola between 100 and 120 min SS and during TT (Coke), or placebo. Improvements in TT were as follows: Precaf, 3.4% (0.2-6.5%, 95% confidence interval); Durcaf, 3.1% (-0.1-6.5%); and Coke, 3.1% (-0.2-6.2%). In Study B, eight subjects received 3 x 5 ml/kg of different cola drinks during the last 40 min of SS and TT: decaffeinated, 6% CHO (control); caffeinated, 6% CHO; decaffeinated, 11% CHO; and caffeinated, 11% CHO (Coke). Coke enhanced TT by 3.3% (0.8-5.9%), with all trials showing 2.2% TT enhancement (0.5-3.8%; P < 0.05) due to caffeine. Overall, 1) 6 mg/kg caffeine enhanced TT performance independent of timing of intake and 2) replacing sports drink with Coca-Cola during the latter stages of exercise was equally effective in enhancing endurance performance, primarily due to low intake of caffeine (approximately 1.5 mg/kg).

  13. ttH multilepton: background estimation

    CERN Document Server

    Angelidakis, Stylianos; The ATLAS collaboration

    2018-01-01

    The slides present the background encountered in the ttH->Multilepton search and describe the data-driven techniques used for the determination of the dominant non-prompt-lepton contamination as well as the contribution of electron charge mis-identification.

  14. On the direct quantification of celecoxib in commercial solid drugs using the TT-PIXE and TT-PIGE techniques

    International Nuclear Information System (INIS)

    Nsouli, B.; Zahraman, K.; Bejjani, A.; Assi, S.; El-Yazbi, F.; Roumie, M.

    2006-01-01

    The quantification of the active ingredient (AI) in drugs is a crucial and important step in the drug quality control process. This is usually performed by using wet chemical techniques like LC-MS, UV spectrophotometry and other appropriate organic analytical methods. In the case of an active ingredient contains specific heteroatoms (F, S, Cl, etc.,), elemental IBA technique can be explored for molecular quantification. IBA techniques permit the analysis of the sample under solid form, without any laborious sample preparation. This is an advantage when the number of sample is relatively large. In this work, we demonstrate the ability of the thick target PIXE (TT-PIXE) and the TT-PIGE techniques for rapid and accurate quantification of celecoxib in commercial drugs. The experimental aspects related to the quantification validity are presented and discussed

  15. The Double Contact Nature of TT Herculis

    OpenAIRE

    Terrell, Dirk; Nelson, Robert H.

    2014-01-01

    We present new radial velocities and photometry of the short-period Algol TT Herculis. Previous attempts to model the light curves of the system have met with limited success, primarily because of the lack of a reliable mass ratio. Our spectroscopic observations are the first to result in radial velocities for the secondary star, and thus provide a spectroscopic mass ratio. Simultaneous analysis of the radial velocities and new photometry shows that the system is a double contact binary, with...

  16. The Double Contact Nature of TT Herculis

    Science.gov (United States)

    Terrell, Dirk; Nelson, Robert H.

    2014-03-01

    We present new radial velocities and photometry of the short-period Algol TT Herculis. Previous attempts to model the light curves of the system have met with limited success, primarily because of the lack of a reliable mass ratio. Our spectroscopic observations are the first to result in radial velocities for the secondary star, and thus provide a spectroscopic mass ratio. Simultaneous analysis of the radial velocities and new photometry shows that the system is a double contact binary, with a rapidly rotating primary that fills its limiting lobe.

  17. NLO QCD predictions for off-shell tt̄ and tt̄H production and decay at a linear collider

    Energy Technology Data Exchange (ETDEWEB)

    Nejad, Bijan Chokoufé [Theory Group, DESY,Notkestr. 85, D-22607 Hamburg (Germany); Kilian, Wolfgang [Emmy-Noether-Campus,Walter-Flex-Str. 3, 57068 Siegen (Germany); Lindert, Jonas M.; Pozzorini, Stefano [Physik-Institut, Universität Zürich,Winterthurerstrasse 190, CH-8057 Zürich (Switzerland); Reuter, Jürgen [Theory Group, DESY,Notkestr. 85, D-22607 Hamburg (Germany); Weiss, Christian [Theory Group, DESY,Notkestr. 85, D-22607 Hamburg (Germany); Emmy-Noether-Campus,Walter-Flex-Str. 3, 57068 Siegen (Germany)

    2016-12-15

    We present predictions for tt̄ and tt̄H production and decay at future lepton colliders including non-resonant and interference contributions up to next-to-leading order (NLO) in perturbative QCD. The obtained precision predictions are necessary for a future precise determination of the top-quark Yukawa coupling, and allow for top-quark phenomenology in the continuum at an unprecedented level of accuracy. Simulations are performed with the automated NLO Monte-Carlo framework Whizard interfaced to the OpenLoops matrix element generator.

  18. Natural and laboratory TT-OSL dose response curves: Testing the lifetime of the TT-OSL signal in nature

    International Nuclear Information System (INIS)

    Chapot, M.S.; Roberts, H.M.; Duller, G.A.T.; Lai, Z.P.

    2016-01-01

    This study compares natural and laboratory generated thermally transferred optically stimulated luminescence (TT-OSL) dose response curves (DRCs) for fine-grain quartz extracts from the Luochuan loess section in central China. Both DRCs saturate at high doses relative to the quartz OSL signal; the natural TT-OSL DRC saturates at about 2200 Gy and laboratory DRCs saturate at about 2700 Gy. However, the natural and laboratory TT-OSL DRCs deviate from one another at circa 150 Gy resulting in TT-OSL equivalent dose underestimation relative to palaeodoses expected from dose rates and independent age control. The lifetime of the TT-OSL signal at 10 °C, calculated from values of trap parameters E and s, is compared against the value for lifetime of the TT-OSL signal in nature at average burial temperature as determined from the age underestimation caused by deviation of the natural and laboratory generated DRCs. These two independent assessments of TT-OSL signal lifetime at Luochuan give similar values, suggesting that laboratory measurements of thermal stability reflect natural burial lifetimes and can potentially be used to correct TT-OSL ages for the difference between natural and laboratory dose response curves. - Highlights: • Natural and laboratory TT-OSL DRCs deviate at ∼150 Gy but saturate at higher doses. • TT-OSL signal lifetime at 10 °C calculated from measured E and s values is ∼180 ka. • TT-OSL signal lifetime at Luochuan estimated from the DRCs' deviation is ∼175 ka. • Natural and laboratory TT-OSL DRC deviation may be caused by low thermal stability. • Laboratory measurements of signal lifetime may be able to correct old TT-OSL ages.

  19. Spacecraft TT&C and information transmission theory and technologies

    CERN Document Server

    Liu, Jiaxing

    2015-01-01

    Spacecraft TT&C and Information Transmission Theory and Technologies introduces the basic theory of spacecraft TT&C (telemetry, track and command) and information transmission. Combining TT&C and information transmission, the book presents several technologies for continuous wave radar including measurements for range, range rate and angle, analog and digital information transmissions, telecommand, telemetry, remote sensing and spread spectrum TT&C. For special problems occurred in the channels for TT&C and information transmission, the book represents radio propagation features and its impact on orbit measurement accuracy, and the effects caused by rain attenuation, atmospheric attenuation and multi-path effect, and polarization composition technology. This book can benefit researchers and engineers in the field of spacecraft TT&C and communication systems. Liu Jiaxing is a professor at The 10th Institute of China Electronics Technology Group Corporation.

  20. Pacing Strategy, Muscle Fatigue and Technique in 1500m Speed Skating and Cycling Time-Trials

    NARCIS (Netherlands)

    Stoter, Inge K; MacIntosh, Brian R; Fletcher, Jared R; Pootz, Spencer; Zijdewind, Inge; Hettinga, Florentina J

    2016-01-01

    PURPOSE: To evaluate pacing behavior and peripheral and central contributions to muscle fatigue in 1500m speed skating and cycling time-trials, when a faster or slower start is instructed. METHODS: Nine speed skaters and nine cyclists, all competing at regional or national level, performed two 1500m

  1. Standard Model tt̄H Production at ATLAS & CMS

    CERN Document Server

    Thomas-Wilsker, Joshuha; The ATLAS collaboration

    2016-01-01

    The Run II ttH analyses benefit from a large increase in the ttH signal cross-section making it a particularly attractive production channel. However, the particularly challenging backgrounds seen in most channels require innovative techniques in order to make the analyses as sensitive as possible. Presented are the first results from the ATLAS ttH analyses using 13TeV collisions at the LHC and updated results presented by CMS at Moriond 2016.

  2. Boiling water reactor turbine trip (TT) benchmark

    International Nuclear Information System (INIS)

    2001-06-01

    In the field of coupled neutronics/thermal-hydraulics computation there is a need to enhance scientific knowledge in order to develop advanced modelling techniques for new nuclear technologies and concepts, as well as for current nuclear applications Recently developed 'best-estimate' computer code systems for modelling 3-D coupled neutronics/thermal-hydraulics transients in nuclear cores and for the coupling of core phenomena and system dynamics (PWR, BWR, VVER) need to be compared against each other and validated against results from experiments. International benchmark studies have been set up for the purpose. The present volume describes the specification of such a benchmark. The transient addressed is a turbine trip (TT) in a BWR involving pressurization events in which the coupling between core phenomena and system dynamics plays an important role. In addition, the data made available from experiments carried out at the plant make the present benchmark very valuable. The data used are from events at the Peach Bottom 2 reactor (a GE-designed BWR/4). (authors)

  3. Time Trials--An AP Physics Challenge Lab

    Science.gov (United States)

    Jones, David

    2009-01-01

    I have come to the conclusion that for high school physics classroom and laboratory experiences, simpler is better! In this paper I describe a very simple and effective lab experience that my AP students have thoroughly enjoyed year after year. I call this lab exercise "Time Trials." The experiment is simple in design and it is a lot of fun for…

  4. Precooling and Warm-Up Effects on Time Trial Cycling During Heat Stress.

    Science.gov (United States)

    Al-Horani, Ramzi A; Wingo, Jonathan E; Ng, Jason; Bishop, Phillip; Richardson, Mark

    2018-02-01

    Heat stress limits endurance exercise performance. Combining precooling and warm-up prior to endurance exercise in the heat may exploit the benefits of both strategies while avoiding the potential negative consequences of each. This study tested the hypothesis that precooling combined with warm-up improves time trial cycling performance in the heat relative to either treatment alone. Nine healthy men completed three 16.1-km time trials in 33°C after: 1) precooling (ice slurry and ice vest) alone (PREC); 2) warm-up alone (WU); or 3) PREC plus WU (COMBO). Tre was lower after PREC compared to WU throughout exercise and lower than COMBO for the first 12 km; COMBO was lower than WU for the first 4 km. Tsk during PREC was lower than COMBO and WU for the first 8 km, and lower in COMBO than WU for the first 4 km. PREC lowered pre-exercise heart rate relative to COMBO and WU (68 ± 10, 106 ± 12, 101 ± 13 bpm, respectively), but it increased similarly during exercise. Local sweat rate (SR) was lower in PREC (0.1 ± 0.1 mg · cm-2 · min-1) than COMBO (0.5 ± 0.2 mg · cm-2 · min-1) and WU (0.6 ± 0.2 mg · cm-2 · min-1) for the first 4 km. Treatments did not differentially affect performance (PREC = 31.9 ± 1.9 min, COMBO = 32.6 ± 2.7 min, WU = 33.1 ± 2.9 min). We conclude precooling alone or with warm-up mitigated thermal strain during exercise, but did not significantly improve 16.1-km cycling time trial performance.Al-horani RA, Wingo JE, Ng J, Bishop P, Richardson M. Precooling and warm-up effects on time trial cycling during heat stress. Aerosp Med Hum Perform. 2018; 89(2):87-93.

  5. The effect of time trial cycling position on physiological and aerodynamic variables.

    Science.gov (United States)

    Fintelman, D M; Sterling, M; Hemida, H; Li, F-X

    2015-01-01

    To reduce aerodynamic resistance cyclists lower their torso angle, concurrently reducing Peak Power Output (PPO). However, realistic torso angle changes in the range used by time trial cyclists have not yet been examined. Therefore the aim of this study was to investigate the effect of torso angle on physiological parameters and frontal area in different commonly used time trial positions. Nineteen well-trained male cyclists performed incremental tests on a cycle ergometer at five different torso angles: their preferred torso angle and at 0, 8, 16 and 24°. Oxygen uptake, carbon dioxide expiration, minute ventilation, gross efficiency, PPO, heart rate, cadence and frontal area were recorded. The frontal area provides an estimate of the aerodynamic drag. Overall, results showed that lower torso angles attenuated performance. Maximal values of all variables, attained in the incremental test, decreased with lower torso angles (P aerodynamic drag and physiological functioning.

  6. A Novel Interference Detection Method of STAP Based on Simplified TT Transform

    Directory of Open Access Journals (Sweden)

    Qiang Wang

    2017-01-01

    Full Text Available Training samples contaminated by target-like signals is one of the major reasons for inhomogeneous clutter environment. In such environment, clutter covariance matrix in STAP (space-time adaptive processing is estimated inaccurately, which finally leads to detection performance reduction. In terms of this problem, a STAP interference detection method based on simplified TT (time-time transform is proposed in this letter. Considering the sparse physical property of clutter in the space-time plane, data on each range cell is first converted into a discrete slow time series. Then, the expression of simplified TT transform about sample data is derived step by step. Thirdly, the energy of each training sample is focalized and extracted by simplified TT transform from energy-variant difference between the unpolluted and polluted stage, and the physical significance of discarding the contaminated samples is analyzed. Lastly, the contaminated samples are picked out in light of the simplified TT transform-spectrum difference. The result on Monte Carlo simulation indicates that when training samples are contaminated by large power target-like signals, the proposed method is more effective in getting rid of the contaminated samples, reduces the computational complexity significantly, and promotes the target detection performance compared with the method of GIP (generalized inner product.

  7. Developmental immunotoxicity is not associated with the consumption of transgenic Bt rice TT51 in rats.

    Science.gov (United States)

    Hu, Jing; Liang, Chunlai; Zhang, Xiaopeng; Zhang, Qiannan; Cui, Wenming; Yu, Zhou

    2018-04-01

    TT51 is a transgenic strain of Bt rice generated by fusing a synthetic CryAb/Ac gene into MingHui rice. In this study, rats from F0, F1, and F2 generations were fed a diet with 60% TT51 rice, MingHui rice, or nominal-origin rice. The study focused on developmental immunotoxicity in F1 and F2 offspring after long-term consumption of TT51. A wide range of immunological parameters was monitored in this two-generation study on reproductive toxicity. The experiments were performed on F1 and F2 offspring at postnatal days 21 and 42. No adverse clinical effects were observed in any of the experimental groups. In addition, histopathology observations and immunotoxicity tests, including hematological indicators, spleen lymphocyte subsets, natural killer cell activity, lymphoproliferative response, and plaque-forming cell assay, revealed no significant difference between the groups. These results indicated that developmental immunotoxicity was not associated with a diet of transgenic Bt rice TT51, compared to the parental MingHui rice. Copyright © 2018 Elsevier Inc. All rights reserved.

  8. Measurement of the ratio σ{tt}/σ{Z/γ{*}→ll} and precise extraction of the tt cross section.

    Science.gov (United States)

    Aaltonen, T; Adelman, J; Alvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauer, G; Beauchemin, P-H; Bedeschi, F; Beecher, D; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Calancha, C; Camarda, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Chung, K; Chung, W H; Chung, Y S; Chwalek, T; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; de Barbaro, P; De Cecco, S; Deisher, A; De Lorenzo, G; Dell'orso, M; Deluca, C; Demortier, L; Deng, J; Deninno, M; d'Errico, M; Di Canto, A; di Giovanni, G P; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Dorigo, T; Dube, S; Ebina, K; Elagin, A; Erbacher, R; Errede, D; Errede, S; Ershaidat, N; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; Garcia, J E; Garfinkel, A F; Garosi, P; Gerberich, H; Gerdes, D; Gessler, A; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Group, R C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, S R; Halkiadakis, E; Han, B-Y; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harr, R F; Hartz, M; Hatakeyama, K; Hays, C; Heck, M; Heinrich, J; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Hou, S; Houlden, M; Hsu, S-C; Hughes, R E; Hurwitz, M; Husemann, U; Hussein, M; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jha, M K; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Ketchum, W; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, H W; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Krumnack, N; Kruse, M; Krutelyov, V; Kuhr, T; Kulkarni, N P; Kurata, M; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecompte, T; Lee, E; Lee, H S; Lee, J S; Lee, S W; Leone, S; Lewis, J D; Lin, C-J; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, T; Lockyer, N S; Loginov, A; Lovas, L; Lucchesi, D; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lys, J; Lysak, R; Macqueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martin, V; Martínez, M; Martínez-Ballarín, R; Mastrandrea, P; Mathis, M; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzione, A; Mesropian, C; Miao, T; Mietlicki, D; Miladinovic, N; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moed, S; Moggi, N; Mondragon, M N; Moon, C S; Moore, R; Morello, M J; Morlock, J; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Nett, J; Neu, C; Neubauer, M S; Neubauer, S; Nielsen, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Osterberg, K; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramanov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Peiffer, T; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Potamianos, K; Poukhov, O; Prokoshin, F; Pronko, A; Ptohos, F; Pueschel, E; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Renton, P; Renz, M; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Rutherford, B; Saarikko, H; Safonov, A; Sakumoto, W K; Santi, L; Sartori, L; Sato, K; Savoy-Navarro, A; Schlabach, P; Schmidt, A; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sforza, F; Sfyrla, A; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shiraishi, S; Shochet, M; Shon, Y; Shreyber, I; Simonenko, A; Sinervo, P; Sisakyan, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soha, A; Somalwar, S; Sorin, V; Squillacioti, P; Stanitzki, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Strycker, G L; Suh, J S; Sukhanov, A; Suslov, I; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thome, J; Thompson, G A; Thomson, E; Tipton, P; Ttito-Guzmán, P; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Tourneur, S; Trovato, M; Tsai, S-Y; Tu, Y; Turini, N; Ukegawa, F; Uozumi, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Vidal, M; Vila, I; Vilar, R; Vogel, M; Volobouev, I; Volpi, G; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wagner-Kuhr, J; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Weinelt, J; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Wilbur, S; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wolfe, H; Wright, T; Wu, X; Würthwein, F; Yagil, A; Yamamoto, K; Yamaoka, J; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanetti, A; Zeng, Y; Zhang, X; Zheng, Y; Zucchelli, S

    2010-07-02

    We report a measurement of the ratio of the tt to Z/γ{*} production cross sections in sqrt[s]=1.96  TeV pp collisions using data corresponding to an integrated luminosity of up to 4.6  fb{-1}, collected by the CDF II detector. The tt cross section ratio is measured using two complementary methods, a b-jet tagging measurement and a topological approach. By multiplying the ratios by the well-known theoretical Z/γ{*}→ll cross section predicted by the standard model, the extracted tt cross sections are effectively insensitive to the uncertainty on luminosity. A best linear unbiased estimate is used to combine both measurements with the result σ{tt}=7.70±0.52  pb, for a top-quark mass of 172.5  GeV/c{2}.

  9. Pacing Strategy, Muscle Fatigue, and Technique in 1500-m Speed-Skating and Cycling Time Trials.

    Science.gov (United States)

    Stoter, Inge K; MacIntosh, Brian R; Fletcher, Jared R; Pootz, Spencer; Zijdewind, Inge; Hettinga, Florentina J

    2016-04-01

    To evaluate pacing behavior and peripheral and central contributions to muscle fatigue in 1500-m speed-skating and cycling time trials when a faster or slower start is instructed. Nine speed skaters and 9 cyclists, all competing at regional or national level, performed two 1500-m time trials in their sport. Athletes were instructed to start faster than usual in 1 trial and slower in the other. Mean velocity was measured per 100 m. Blood lactate concentrations were measured. Maximal voluntary contraction (MVC), voluntary activation (VA), and potentiated twitch (PT) of the quadriceps muscles were measured to estimate central and peripheral contributions to muscle fatigue. In speed skating, knee, hip, and trunk angles were measured to evaluate technique. Cyclists showed a more explosive start than speed skaters in the fast-start time trial (cyclists performed first 300 m in 24.70 ± 1.73 s, speed skaters in 26.18 ± 0.79 s). Both trials resulted in reduced MVC (12.0% ± 14.5%), VA (2.4% ± 5.0%), and PT (25.4% ± 15.2%). Blood lactate concentrations after the time trial and the decrease in PT were greater in the fast-start than in the slow-start trial. Speed skaters showed higher trunk angles in the fast-start than in the slow-start trial, while knee angles remained similar. Despite similar instructions, behavioral adaptations in pacing differed between the 2 sports, resulting in equal central and peripheral contributions to muscle fatigue in both sports. This provides evidence for the importance of neurophysiological aspects in the regulation of pacing. It also stresses the notion that optimal pacing needs to be studied sport specifically, and coaches should be aware of this.

  10. Time course for the recovery of physical performance, blood hemoglobin, and ferritin content after blood donation

    DEFF Research Database (Denmark)

    Ziegler, Andreas K; Grand, Johannes; Stangerup, Ida

    2015-01-01

    BACKGROUND: It is widely accepted that blood donation negatively affects endurance performance, but data on physical recovery after a standard blood donation are scarce. This study aimed to elucidate the temporary impact of blood donation on endurance performance, measured as peak oxygen uptake (VO......2peak ) and time trial (TT) performance. STUDY DESIGN AND METHODS: VO2peak , TT performance, blood, iron, and anthropometric variables were determined before (baseline) and 3, 7, 14, and 28 days after blood donation in 19 healthy men. RESULTS: VO2peak was reduced by 6.5% from 49.7 ± 2 m......L/kg/min at baseline to 46.3 ± 2 mL/kg/min on Day 3 (p donation. Blood hemoglobin (Hb) concentration declined 7.9% from 9.3 ± 0.11 mmol...

  11. The behavior of an opponent alters pacing decisions in 4-km cycling time trials.

    Science.gov (United States)

    Konings, Marco J; Schoenmakers, Patrick P J M; Walker, Andrew J; Hettinga, Florentina J

    2016-05-01

    The present study aimed to explore how athletes respond to different behaviors of their opponents. Twelve moderately to highly physically active participants with at least two years of cycling experience completed four 4-km time trials on a Velotron cycle ergometer. After a familiarization time trial (FAM), participants performed three experimental time trials in randomized order with no opponent (NO), a virtual opponent who started slower and finished faster compared to FAM (OP-SLOWFAST), or a virtual opponent who started faster and finished slower compared to FAM (OP-FASTSLOW). Repeated-measures ANOVAs (Ppower output, velocity and RPE. OP-SLOWFAST and OP-FASTSLOW were completed faster compared to NO (385.5±27.5, 385.0±28.6, and 390.6±29.3s, respectively). An interaction effect for condition×distance (F=3.944, Ppower outputs by the participants in the initial 750m compared to a slower starting opponent. The present study is the first to show that the behavior of an opponent affects pacing-related decisions in laboratory-controlled conditions. Our findings support the recently proposed interdependence of perception and action, and emphasize the interaction with the environment as an important determinant for an athlete's pacing decisions, especially during the initial stages of a race. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Effect of Physical Load on Aerobic Exercise Performance during Heat Stress.

    Science.gov (United States)

    Kenefick, Robert W; Heavens, Kristen R; Luippold, Adam J; Charkoudian, Nisha; Schwartz, Steven A; Cheuvront, Samuel N

    2017-12-01

    This study aimed to investigate the effect of increasing external loads on 5-km treadmill time trial (TT) performance in 20°C and 40°C environmental conditions and to construct an ecologically relevant performance prediction decision aid. Twenty-six male and four female volunteers (age, 23.5 ± 6.9 yr; weight, 76.0 ± 8.9 kg; height, 1.75 ± 0.07 m; V˙O2peak, 50.7 ± 4.5 mL·kg·min) participated in a counterbalanced, mixed-model design, with each subject assigned to a load group (20%, 30%, or 50% body mass (BM); n = 10 per group). Volunteers performed three, self-paced 5-km familiarization TT (treadmill) without external load. Each volunteer then performed a 5-km TT in each environment with loads of either 20% (n = 10), 30% (n = 10), or 50% (n = 10) of BM. 1) Loads of (20%, 30%, and 50% of BM) impaired 5-km TT performance compared with that when unloaded (P exercise trials, an ecologically valid decision aid was developed from self-paced data, in which pace (km·h) can be predicted for individual levels of heat, load, or heat + load in combination.

  13. Trash to Supply Gas (TtSG) Project Overview

    Science.gov (United States)

    Hintze, Paul; Santiago-Maldonado, Edgardo; Kulis, Michael J.; Lytle, John K.; Fisher, John W.; Vaccaro, Helen; Ewert, Michael K.; Broyan, James L.

    2012-01-01

    Technologies that reduce logistical needs are a key to long term space missions. Currently, trash and waste generated during a mission is carried during the entire roundtrip mission or stored inside a logistic module which is de-orbited into Earth's atmosphere for destruction. The goal of the Trash to Supply Gas (TtSG) project is to develop space technology alternatives for converting trash and other waste materials from human spaceflight into high-value products that might include propellants or power system fuels in addition to life support oxygen and water. In addition to producing a useful product from waste, TtSG will decrease the volume needed to store waste on long term space missions. This paper presents an overview of the TtSG technologies and future plans for the project.

  14. Composite Higgs Models and the tt-bar H Channel

    International Nuclear Information System (INIS)

    Carmona, A.; Chala, M.; Santiago, J.

    2012-01-01

    Despite its suppressed couplings to Standard Model particles, a composite Higgs with mass m H = 125 GeV and a moderate degree of compositeness can be consistent with current Higgs searches, including a sizable enhancement in the H → γγ channel. Heavy resonances common to many composite Higgs models can mediate new Higgs production mechanisms. In particular, the tt-bar H channel can be accessible at the LHC in these models through the exchange of colored vector and fermion resonances. In this case, the tt-bar H channel is not a direct measure of the top Yukawa coupling. (authors)

  15. Physiological and performance responses to a preseason altitude-training camp in elite team-sport athletes.

    Science.gov (United States)

    McLean, Blake D; Buttifant, David; Gore, Christopher J; White, Kevin; Liess, Carsten; Kemp, Justin

    2013-07-01

    Little research has been done on the physiological and performance effects of altitude training on team-sport athletes. Therefore, this study examined changes in 2000-m time-trial running performance (TT), hemoglobin mass (Hbmass), and intramuscular carnosine content of elite Australian Football (AF) players after a preseason altitude camp. Thirty elite AF players completed 19 days of living and training at either moderate altitude (~2130 m; ALT, n = 21) or sea level (CON, n = 9). TT performance and Hbmass were assessed preintervention (PRE) and postintervention (POST1) in both groups and at 4 wk after returning to sea level (POST2) in ALT only. Improvement in TT performance after altitude was likely 1.5% (± 4.8-90%CL) greater in ALT than in CON, with an individual responsiveness of 0.8%. Improvements in TT were maintained at POST2 in ALT. Hbmass after altitude was very likely increased in ALT compared with CON (2.8% ± 3.5%), with an individual responsiveness of 1.3%. Hbmass returned to baseline at POST2. Intramuscular carnosine did not change in either gastrocnemius or soleus from PRE to POST1. A preseason altitude camp improved TT performance and Hbmass in elite AF players to a magnitude similar to that demonstrated by elite endurance athletes undertaking altitude training. The individual responsiveness of both TT and Hbmass was approximately half the group mean effect, indicating that most players gained benefit. The maintenance of running performance for 4 wk, despite Hbmass returning to baseline, suggests that altitude training is a valuable preparation for AF players leading into the competitive season.

  16. Oral Presence of Carbohydrate and Caffeine in Chewing Gum: Independent and Combined Effects on Endurance Cycling Performance.

    Science.gov (United States)

    Oberlin-Brown, Katherine T; Siegel, Rodney; Kilding, Andrew E; Laursen, Paul B

    2016-03-01

    The oral presence of carbohydrate (CHO) and caffeine (CAF) may independently enhance exercise performance, but their influence on performance during prolonged exercise is less known. To determine the independent and combined effects of CHO and CAF administered in chewing gum during a cycling time trial (TT) after prolonged exercise. Eleven male cyclists (32.2 ± 7.5 y, 74.3 ± 6.8 kg, 60.2 ± 4.0 mL · kg-1 · min-1 VO2peak) performed 4 experimental trials consisting of 90-min constant-load cycling at 80% of their second ventilatory threshold (207 ± 30 W), followed immediately by a 20-km TT. Under double-blinded conditions, cyclists received placebo (PLA), CHO, CAF, or a combined CHO+CAF chewing gum at 0-, 5-, 10-, and 15-km points of the TT. Overall TT performance was similar across experimental and PLA trials (%mean difference ± 90%CL 0.2% ± 2.0%, 0.4% ± 2.2%, 0.1% ± 1.8% for CHO, CAF, and CHO+CAF). Compared with PLA, mean power output tended to be higher in the first 2 quarters of the TT with CHO (1.6% ± 3.1% and 0.8% ± 2.0%) and was substantially improved in the last 2 quarters during CAF and CHO+CAF trials (4.2% ± 3.0% and 2.0% ± 1.8%). There were no differences in average heart rate (ES performance. Blood lactate was substantially higher post-TT for CAF and CHO+CAF (ES >0.6). After prolonged constant-load cycling, the oral presence of CHO and CAF in chewing gum, independently or in combination, did not improve overall performance but did influence pacing.

  17. Analytical TEM of service-induced SCC in alloy 600TT steam generator tubing

    International Nuclear Information System (INIS)

    Wolfe, R.; Legras, L.; Boccanfuso; Martin, A.

    2015-01-01

    In 2008, Vogtle Electric Generating Plant Unit 1 performed tube pulls to confirm outside diameter stress corrosion cracking (ODSCC) in a steam generator with thermally treated Alloy 600TT tubing. Subsequent metallographic and other laboratory work attributed the cracking to the non-optimal microstructure of the tubing and the elevated residual stresses at the expansion transition. In the current work, analytical transmission electron microscopy was performed to gain a better understanding of this in-service cracking through a detailed characterization of the oxides and crack tips. These examinations, which are the first of this kind for U.S. Alloy 600TT tubing service cracks, detected lead (Pb) in the region of the top-of-tube sheet crevice, in oxides at the crack tips, and at degraded grain boundaries. In addition, sulfur was observed in oxides on the outside surface of the tube in the free span area. The presence of Pb at the crack tip and the lack of plasticity on the observed failure surfaces suggest that the environment played a predominant role in the cracking of this tubing with a non-optimal microstructure. The significance of the degradation will be discussed in the context of overall corrosion indications in Alloy 600TT steam generators in the United States. (authors)

  18. TT-C-490 -Implementing Alternatives Through Specifications (Briefing Charts)

    Science.gov (United States)

    2014-11-18

    coating or wash primer conforming to DOD-P-15328 or MIL-C-8514 – Wash primers contain hexavalent chromium • Also high in VOCs and contain HAPs...memo (April 8, 2009) mandating reduction in chrome has led to elimination of TT-C-490 Type III (DoD-P-15328) on most new contracts – Impending

  19. 31 CFR 203.3 - TT&L depositaries.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false TT&L depositaries. 203.3 Section 203.3 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE PAYMENT OF FEDERAL TAXES AND THE TREASURY TAX AND...

  20. Experiment-specific cosmic microwave background calculations made easier - Approximation formula for smoothed delta T/T windows

    Science.gov (United States)

    Gorski, Krzysztof M.

    1993-01-01

    Simple and easy to implement elementary function approximations are introduced to the spectral window functions needed in calculations of model predictions of the cosmic microwave backgrond (CMB) anisotropy. These approximations allow the investigator to obtain model delta T/T predictions in terms of single integrals over the power spectrum of cosmological perturbations and to avoid the necessity of performing the additional integrations. The high accuracy of these approximations is demonstrated here for the CDM theory-based calculations of the expected delta T/T signal in several experiments searching for the CMB anisotropy.

  1. The effect of pre-exercise ingestion of corinthian currant on endurance performance and blood redox status.

    Science.gov (United States)

    Deli, Chariklia K; Poulios, Athanasios; Georgakouli, Kalliopi; Papanikolaou, Konstantinos; Papoutsis, Alexandros; Selemekou, Maria; Karathanos, Vaios T; Draganidis, Dimitris; Tsiokanos, Athanasios; Koutedakis, Yiannis; Fatouros, Ioannis G; Jamurtas, Athanasios Z

    2018-02-22

    The present study investigated the effect of Corinthian currant pre-exercise supplementation on metabolism, performance and blood redox status during, and after prolonged exercise. Eleven healthy participants (21-45y) performed a 90-min constant-intensity (60-70% VO 2max ) submaximal-trial, plus a time-trial (TT) to exhaustion (95% VO 2max ) after consuming an isocaloric (1.5g CHO/kg BM) amount of randomly assigned Corinthian currant or glucose-drink, or water (control). Blood was drawn at baseline, pre-exercise, 30min, 60min, 90min of submaximal-trial, post-TT, and 1h post-TT. Post-ingestion blood glucose (GLU) under Corinthian currant was higher compared with water, and similar compared with glucose-drink throughout the study. Respiratory quotient under Corinthian currant was similar with glucose-drink and higher than water throughout the submaximal trial. Accordingly, higher CHO and lower fat oxidation were observed under Corinthian currant compared with water. The TT performance was similar between Corinthian currant, glucose-drink and water. Redox status were similar under all three conditions. Reduced glutathione (GSH) declined while total antioxidant capacity (TAC) and uric acid increased during exercise. GSH and TAC returned to baseline, while uric acid remained increased the following 1h. Corinthian currant, although did not alter exercise-mediated redox status changes and performance, was equally effective to a glucose-drink in maintaining GLU levels during prolonged cycling.

  2. Possible first occurrence of external corrosion on alloy 600TT tubes in France

    International Nuclear Information System (INIS)

    Boccanfuso, M.; Thebault, Y.; Massini, B.; Bigne, L.

    2015-01-01

    During the last decade, in different countries, several occurrences of external corrosion have been identified on steam generator (SG) tube bundles equipped with thermally treated 600 alloy. In France, this feedback leads EDF to enhance the SG inspection program. Nevertheless, until now, no damage of this type was reported. Recently, during in-service inspection at the Cattenom plant on a SG equipped with alloy 600TT tubes, Eddy current tests have highlighted a signal that could be related to external corrosion. The tube was removed and sent to the EDF hot laboratory for destructive examinations. Various exams were performed at different scales to characterize the causes of this NDT signal, the material properties and the residual stresses. The assessments carried out on the tube conclude that the source of the damage is external intergranular stress corrosion cracking, also called ODSCC (Outside Diameter Stress Corrosion Cracking) making it the first occurrence on the tube bundles made of alloy 600TT in the French fleet. This first case of 600 TT ODSCC in France is an unexpected and particular one, because of its altitude in the full mechanical rolling area. This is reinforced by the low number of occurrences noted to date (only one after nearly 30 years of operation of alloy 600TT tube bundles). International (Biblis) OPEX had identified recent IGSCC with cracks initiated and propagated in the tubesheet. For this case, the scenario considered requires highly restrictive conditions (tube in the sludge zone and on the periphery of the tube bundle, including the tube lane) and may explain the singular nature of the Cattenom tube

  3. A Monetary Reward Alters Pacing but Not Performance in Competitive Cyclists.

    Science.gov (United States)

    Skorski, Sabrina; Thompson, Kevin G; Keegan, Richard J; Meyer, Tim; Abbiss, Chris R

    2017-01-01

    Money has frequently been used as an extrinsic motivator since it is assumed that humans are willing to invest more effort for financial reward. However, the influence of a monetary reward on pacing and performance in trained athletes is not well-understood. Therefore, the aim of this study was to analyse the influence of a monetary reward in well-trained cyclists on their pacing and performance during short and long cycling time trials (TT). Twentythree cyclists (6 ♀, 17 ♂) completed 4 self-paced time trials (TTs, 2 short: 4 km and 6 min; 2 long: 20 km and 30 min); in a randomized order. Participants were separated into parallel, non-randomized "rewarded" and "non-rewarded" groups. Cyclists in the rewarded group received a monetary reward based on highest mean power output across all TTs. Cyclists in the non-rewarded group did not receive a monetary reward. Overall performance was not significantly different between groups in short or long TTs ( p > 0.48). Power output showed moderatly lower effect sizes at comencement of the short TTs ( P meandiff = 36.6 W; d > 0.44) and the 20 km TT ( P meandiff = 22.6 W; d = 0.44) in the rewarded group. No difference was observed in pacing during the 30 min TT ( p = 0.95). An external reward seems to have influenced pacing at the commencement of time trials. Participants in the non-rewarded group adopted a typical parabolic shaped pattern, whereas participants in the rewarded group started trials more conservatively. Results raise the possibility that using money as an extrinsic reward may interfere with regulatory processes required for effective pacing.

  4. A Monetary Reward Alters Pacing but Not Performance in Competitive Cyclists

    Directory of Open Access Journals (Sweden)

    Sabrina Skorski

    2017-09-01

    Full Text Available Money has frequently been used as an extrinsic motivator since it is assumed that humans are willing to invest more effort for financial reward. However, the influence of a monetary reward on pacing and performance in trained athletes is not well-understood. Therefore, the aim of this study was to analyse the influence of a monetary reward in well-trained cyclists on their pacing and performance during short and long cycling time trials (TT. Twentythree cyclists (6 ♀, 17 ♂ completed 4 self-paced time trials (TTs, 2 short: 4 km and 6 min; 2 long: 20 km and 30 min; in a randomized order. Participants were separated into parallel, non-randomized “rewarded” and “non-rewarded” groups. Cyclists in the rewarded group received a monetary reward based on highest mean power output across all TTs. Cyclists in the non-rewarded group did not receive a monetary reward. Overall performance was not significantly different between groups in short or long TTs (p > 0.48. Power output showed moderatly lower effect sizes at comencement of the short TTs (Pmeandiff = 36.6 W; d > 0.44 and the 20 km TT (Pmeandiff = 22.6 W; d = 0.44 in the rewarded group. No difference was observed in pacing during the 30 min TT (p = 0.95. An external reward seems to have influenced pacing at the commencement of time trials. Participants in the non-rewarded group adopted a typical parabolic shaped pattern, whereas participants in the rewarded group started trials more conservatively. Results raise the possibility that using money as an extrinsic reward may interfere with regulatory processes required for effective pacing.

  5. Metabolic Responses and Pacing Strategies during Successive Sprint Skiing Time Trials

    DEFF Research Database (Denmark)

    Andersson, Erik; Holmberg, Hans-Christer; Ørtenblad, Niels

    2016-01-01

    PURPOSE: To examine the metabolic responses and pacing strategies during the performance of successive sprint time trials (STTs) in cross-country skiing. METHODS: Ten well-trained male cross-country skiers performed four self-paced 1300-m STTs on a treadmill, each separated by 45 min of recovery...... to estimate the anaerobic energy supply. RESULTS: The individual trial-to-trial variability in STT performance time was 1.3%, where variations in O2 deficit and V˙O2 explained 69% (P 0.05) of the variation in performance. The first and last STTs were equally fast (228 ± 10 s), and ~ 1...... on the first than second course half. In addition, metabolic rates were substantially higher (~_30%) for uphill than for flat skiing, indicating that pacing was regulated to the terrain. CONCLUSIONS: The fastest STTs were characterized primarily by a greater anaerobic energy production, which also explained 69...

  6. Effect of tt-farnesol and myricetin on in vitro biofilm formed by Streptococcus mutans and Candida albicans.

    Science.gov (United States)

    Rocha, Guilherme Roncari; Florez Salamanca, Elkin Jahir; de Barros, Ana Letícia; Lobo, Carmélia Isabel Vitorino; Klein, Marlise Inêz

    2018-02-14

    Dental caries is considered a multifactorial disease, in which microorganisms play an important role. The diet is decisive in the biofilm formation because it provides the necessary resources for cellular growth and exopolysaccharides synthesis. Exopolysaccharides are the main components of the extracellular matrix (ECM). The ECM provides a 3D structure, support for the microorganisms and form diffusion-limited environments (acidic niches) that cause demineralization of the dental enamel. Streptococcus mutans is the main producer of exopolysaccharides. Candida albicans is detected together with S. mutans in biofilms associated with severe caries lesions. Thus, this study aimed to determine the effect of tt-farnesol and myricetin topical treatments on cariogenic biofilms formed by Streptococcus mutans and Candida albicans. In vitro dual-species biofilms were grown on saliva-coated hydroxyapatite discs, using tryptone-yeast extract broth with 1% sucrose (37 °C, 5% CO 2 ). Twice-daily topical treatments were performed with: vehicle (ethanol 15%, negative control), 2 mM myricetin, 4 mM tt-farnesol, myricetin + tt-farnesol, myricetin + tt-farnesol + fluoride (250 ppm), fluoride, and chlorhexidine digluconate (0.12%; positive control). After 67 h, biofilms were evaluated to determine biofilm biomass, microbial population, and water-soluble and -insoluble exopolysaccharides in the ECM. Only the positive control yielded a reduced quantity of biomass and microbial population, while tt-farnesol treatment was the least efficient in reducing C. albicans population. The combination therapy myricetin + farnesol + fluoride significantly reduced water-soluble exopolysaccharides in the ECM (vs. negative control; p < 0.05; ANOVA one-way, followed by Tukey's test), similarly to the positive control. Therefore, the combination therapy negatively influenced an important virulence trait of cariogenic biofilms. However, the concentrations of both myricetin and tt

  7. Effects of potassium iodide in concentrations of TSH, tT3 and tT4 in serum of subjects with sporotrichosis.

    Science.gov (United States)

    Ramírez Soto, Max Carlos

    2014-08-01

    The saturated potassium iodide solution (SSKI) as treatment for sporotrichosis may cause hypothyroidism by suppressing the synthesis of thyroid hormones (tT3 and tT4 ) and the iodine excess could lead to thyrotoxicosis. Evaluating the changes in serum levels of TSH, tT3 and tT4 in euthyroid patients with sporotrichosis treated with SSKI. For the selection of euthyroid patients, TSH, tT3 and tT4 concentrations were measured for those adults and children diagnosed with sporotrichosis. Each paediatric patient was administered SSKI orally in increasing doses of 2-20 drops/3 times/day and 4-40 drops/3 times/day in adults. Serum concentrations of TSH, tT3 and tT4 were measured 20 days after started the treatment and 15 days posttreatment. Eight euthyroid patients aged between 2 to 65 years old were included. After 20 days of treatment, two suffered subclinical hypothyroidism, one developed subclinical hyperthyroidism, and one hyperthyroxinaemia euthyroid. At 15 days posttreatment only four patients were evaluated and all serum levels of TSH, tT3 and tT4 were normal. Some euthyroid patients with sporotrichosis can develop hyperthyroidism or subclinical iodine-induced hypothyroidism, during the administration of 3 or 6 g SSKI/day. © 2014 Blackwell Verlag GmbH.

  8. A novel process control method for a TT-300 E-Beam/X-Ray system

    Science.gov (United States)

    Mittendorfer, Josef; Gallnböck-Wagner, Bernhard

    2018-02-01

    This paper presents some aspects of the process control method for a TT-300 E-Beam/X-Ray system at Mediscan, Austria. The novelty of the approach is the seamless integration of routine monitoring dosimetry with process data. This allows to calculate a parametric dose for each production unit and consequently a fine grain and holistic process performance monitoring. Process performance is documented in process control charts for the analysis of individual runs as well as historic trending of runs of specific process categories over a specified time range.

  9. TT detector description and implementation of the survey measurements

    CERN Document Server

    Salzmann, C

    2008-01-01

    The TT geometry in the software has been updated to comply with the latest technical drawings. The main difference is in the description of the beam pipe insulation, where the amount of material has increased from $7.5\\%$ to $15.4\\%$ of $X_0$. Mother volumes are added to decrease the CPU consumption and finally several scans are made to compare the material budget between the DC06 geometry and the new 2008 geometry. In addition, the survey measurements of the TT detector have been analysed. These measurements can be subdivided into surveys of the detector box, photogrammetry of the balconies and metrology of the half-modules. The offsets with the nominal geometry are implemented in the alignment condition database.

  10. SPS transfer line TT60 towards W-Area

    CERN Multimedia

    CERN PhotoLab

    1978-01-01

    Tranfer line TT60 from SPS LSS6 towards the W-Area. View in the direction of the beam. After the magnet, there is a secondary-emission profile monitor, followed by a secondary-emission split-foil (for centering the beam). A TV camera (sticking up prominently) looks at a scintillator screen. The huge tank (with a person standing behind it) houses a beam dump (allowing setting- up of extraction without sending a beam to the W-Area).

  11. Spin-spin correlations in the tt'-Hubbard model

    International Nuclear Information System (INIS)

    Husslein, T.; Newns, D.M.; Mattutis, H.G.; Pattnaik, P.C.; Morgenstern, I.; Singer, J.M.; Fettes, W.; Baur, C.

    1994-01-01

    We present calculations of the tt'-Hubbard model using Quantum Monte Carlo techniques. The parameters are chosen so that the van Hove Singularity in the density of states and the Fermi level coincide. We study the behaviour of the system with increasing Hubbard interaction U. Special emphasis is on the spin-spin correlation (SSC). Unusual behaviour for large U is observed there and in the momentum distribution function (n(q)). (orig.)

  12. Preliminary PCA/TT Results on MRO CRISM Multispectral Images

    Science.gov (United States)

    Klassen, David R.; Smith, M. D.

    2010-10-01

    Mars Reconnaissance Orbiter arrived at Mars in March 2006 and by September had achieved its science-phase orbit with the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) beginning its visible to near-infrared (VIS/NIR) spectral imaging shortly thereafter. One goal of CRISM is to fill in the spatial gaps between the various targeted observations, eventually mapping the entire surface. Due to the large volume of data this would create, the instrument works in a reduced spectral sampling mode creating "multispectral” images. From these data we can create image cubes using 64 wavelengths from 0.410 to 3.923 µm. We present here our analysis of these multispectral mode data products using Principal Components Analysis (PCA) and Target Transformation (TT) [1]. Previous work with ground-based images [2-5] has shown that over an entire visible hemisphere, there are only three to four meaningful components using 32-105 wavelengths over 1.5-4.1 µm the first two are consistent over all temporal scales. The TT retrieved spectral endmembers show nearly the same level of consistency [5]. The preliminary work on the CRISM images cubes implies similar results; three to four significant principal components that are fairly consistent over time. These components are then used in TT to find spectral endmembers which can be used to characterize the surface reflectance for future use in radiative transfer cloud optical depth retrievals. We present here the PCA/TT results comparing the principal components and recovered endmembers from six reconstructed CRISM multi-spectral image cubes. References: [1] Bandfield, J. L., et al. (2000) JGR, 105, 9573. [2] Klassen, D. R. and Bell III, J. F. (2001) BAAS 33, 1069. [3] Klassen, D. R. and Bell III, J. F. (2003) BAAS, 35, 936. [4] Klassen, D. R., Wark, T. J., Cugliotta, C. G. (2005) BAAS, 37, 693. [5] Klassen, D. R. (2009) Icarus, 204, 32.

  13. Observations of TT Ari requested in support of MOST observations

    Science.gov (United States)

    Waagen, Elizabeth O.

    2012-08-01

    Dr. Nikolaus Vogt (Universidad de Valparaiso, Chile) requested simultaneous photometry and spectroscopy of the novalike (VY Scl subtype) cataclysmic variable TT Ari in support of upcoming observations with the Canadian Microvariability and Oscillations of Stars (MOST) satellite 2012 September 13 through October 20. The Departamento de Fisica y Astronomia of the Valparaiso University will carry out photometry with small telescopes in central Chile but the assistance of other observers, particularly in other latitudes and longitudes, is requested. The observations are being carried out to study superhump behavior, which is still not well understood despite the amount of research done in all classes of cataclysmic variables. TT Ari exibits superhumps - both positive (the superhump period is longer than the orbital period) and negative (the superhump period is shorter than the orbital period). While positive superhumps are thought probably to be the result of an eccentric configuration in the accretion disk, the mechanism for negative superhumps is not yet understood except that it may be related to the disk's being warped out of the orbital plane, leading to complex torque phenomena. TT Ari, one of the brightest cataclysmic variables, exhibits occasional fadings of several magnitudes, from its usual high-state (maximum) magnitude of ~10.5V to a low-state magnitude as faint as 16V. These fadings occur every 20-25 years, and last between 500 and 1000 days. According to observations in the AAVSO International Database, TT Ari is currently magnitude 10.5V. Finder charts with sequence may be created using the AAVSO Variable Star Plotter (http://www.aavso.org/vsp). Observations should be submitted to the AAVSO International Database. See full Alert Notice for more details, particularly regarding goals of the campaign, and observing instructions.

  14. Mouth rinsing improves cycling endurance performance during Ramadan fasting in a hot humid environment.

    Science.gov (United States)

    Che Muhamed, Ahmad Munir; Mohamed, Nazirah Gulam; Ismail, Norjana; Aziz, Abdul Rashid; Singh, Rabindarjeet

    2014-04-01

    This study examined the effect of mouth rinsing during endurance cycling in a hot humid environment (32 °C and 75% relative humidity) on athletes in the Ramadan fasted state. Nine trained adolescent male cyclists completed 3 trials that consisted of a carbohydrate mouth-rinse (CMR), a placebo mouth-rinse (PMR), and a no-rinse (NOR) trial during the last 2 weeks of Ramadan. Each trial consisted of a preloading cycle at 65% peak rate of oxygen consumption for 30 min followed by a 10-km time trial (TT10 km) under hot humid condition. During the CMR and PMR trials, each cyclist rinsed his mouth with 25 mL of the solution for 5 s before expectorating the solution pre-exercise, after 5, 15, and 25 min of the preloading cycle, and 15 s prior to the start of TT10 km. Time to complete the TT10 km was significantly faster in the CMR and PMR trials compared with the NOR trial (12.9 ± 1.7 and 12.6 ± 1.7 vs. 16.8 ± 1.6 min, respectively; p benefits compared with a no-rinse condition on TT10 km performance in acute Ramadan fasted subjects during endurance cycling in a heat stress environment.

  15. 31 CFR 203.6 - Obligations of TT&L depositaries.

    Science.gov (United States)

    2010-07-01

    ... TREASURY TAX AND LOAN PROGRAM General Information § 203.6 Obligations of TT&L depositaries. A TT&L depositary must: (a) Administer a TIP main account balance, SDI account balance, or TIO account balance, as...

  16. Altitude Training in Elite Swimmers for Sea Level Performance (Altitude Project).

    Science.gov (United States)

    Rodríguez, Ferran A; Iglesias, Xavier; Feriche, Belén; Calderón-Soto, Carmen; Chaverri, Diego; Wachsmuth, Nadine B; Schmidt, Walter; Levine, Benjamin D

    2015-09-01

    This controlled, nonrandomized, parallel-groups trial investigated the effects on performance, V˙O2 and hemoglobin mass (tHbmass) of four preparatory in-season training interventions: living and training at moderate altitude for 3 and 4 wk (Hi-Hi3, Hi-Hi), living high and training high and low (Hi-HiLo, 4 wk), and living and training at sea level (SL) (Lo-Lo, 4 wk). From 61 elite swimmers, 54 met all inclusion criteria and completed time trials over 50- and 400-m crawl (TT50, TT400), and 100 (sprinters) or 200 m (nonsprinters) at best stroke (TT100/TT200). Maximal oxygen uptake (V˙O2max) and HR were measured with an incremental 4 × 200 m test. Training load was estimated using cumulative training impulse method and session RPE. Initial measures (PRE) were repeated immediately (POST) and once weekly on return to SL (PostW1 to PostW4). tHbmass was measured in duplicate at PRE and once weekly during the camp with CO rebreathing. Effects were analyzed using mixed linear modeling. TT100 or TT200 was worse or unchanged immediately at POST, but improved by approximately 3.5% regardless of living or training at SL or altitude after at least 1 wk of SL recovery. Hi-HiLo achieved greater improvement 2 (5.3%) and 4 wk (6.3%) after the camp. Hi-HiLo also improved more in TT400 and TT50 2 (4.2% and 5.2%, respectively) and 4 wk (4.7% and 5.5%) from return. This performance improvement was not linked linearly to changes in V˙O2max or tHbmass. A well-implemented 3- or 4-wk training camp may impair performance immediately but clearly improves performance even in elite swimmers after a period of SL recovery. Hi-HiLo for 4 wk improves performance in swimming above and beyond altitude and SL controls through complex mechanisms involving altitude living and SL training effects.

  17. Caffeine and 3-km cycling performance: Effects of mouth rinsing, genotype, and time of day.

    Science.gov (United States)

    Pataky, M W; Womack, C J; Saunders, M J; Goffe, J L; D'Lugos, A C; El-Sohemy, A; Luden, N D

    2016-06-01

    We assessed the efficacy of caffeine mouth rinsing on 3-km cycling performance and determined whether caffeine mouth rinsing affects performance gains influenced by the CYP1A2 polymorphism. Thirty-eight recreational cyclists completed four simulated 3-km time trials (TT). Subjects ingested either 6 mg/kg BW of caffeine or placebo 1 h prior to each TT. Additionally, 25 mL of 1.14% caffeine or placebo solution were mouth rinsed before each TT. The treatments were Placebo, caffeine Ingestion, caffeine Rinse and Ingestion+Rinse. Subjects were genotyped and classified as AA homozygotes or AC heterozygotes for the rs762551 polymorphism of the CYP1A2 gene involved in caffeine metabolism. Magnitude-based inferences were used to evaluate treatment differences in mean power output based on a predetermined meaningful treatment effect of 1.0%. AC heterozygotes (4.1%) and AA homozygotes (3.4%) benefited from Ingestion+Rinse, but only AC performed better with Ingestion (6.0%). Additionally, Rinse and Ingestion+Rinse elicited better performance relative to Placebo among subjects that performed prior to 10:00 h (Early) compared with after 10:00 h (Late). The present study provides additional evidence of genotype and time of day factors that affect the ergogenic value of caffeine intake that may allow for more personalized caffeine intake strategies to maximize performance. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  18. Die taal as katedraal: Driepas van T.T. Cloete

    Directory of Open Access Journals (Sweden)

    A. van Jaarsveld

    1995-05-01

    In the compilation of Driepas the poet T.T. Cloete intended to build a cathedral in language. In this article the structural characteristics of the Gothic cathedral, specifically those of the Chartres cathedral, are examined to determine possible structural correlations between the edifice and the poetic artefact. The structural links between the cathedral of Chartres and the poems in Driepas were mainly ascertained by implementing the analogy of Cloete’s bountiful usage of enumeration and his meticulous attention to detailed arrangement. This aspect has previously been overlooked by most critics of Driepas.

  19. Aerodynamic study of time-trial helmets in cycling racing using CFD analysis.

    Science.gov (United States)

    Beaumont, F; Taiar, R; Polidori, G; Trenchard, H; Grappe, F

    2018-01-23

    The aerodynamic drag of three different time-trial cycling helmets was analyzed numerically for two different cyclist head positions. Computational Fluid Dynamics (CFD) methods were used to investigate the detailed airflow patterns around the cyclist for a constant velocity of 15 m/s without wind. The CFD simulations have focused on the aerodynamic drag effects in terms of wall shear stress maps and pressure coefficient distributions on the cyclist/helmet system. For a given head position, the helmet shape, by itself, obtained a weak effect on a cyclist's aerodynamic performance (CFD results have also shown that both helmet shape and head position significantly influence drag forces, pressure and wall shear stress distributions on the whole cyclist's body due to the change in the near-wake behavior and in location of corresponding separation and attachment areas around the cyclist. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. The TT, TB, EB and BB correlations in anisotropic inflation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Xingang [Department of Physics, The University of Texas at Dallas, Richardson, TX 75083 (United States); Emami, Razieh [School of Physics, Institute for Research in Fundamental Sciences (IPM), P. O. Box 19395-5531, Tehran (Iran, Islamic Republic of); Firouzjahi, Hassan [School of Astronomy, Institute for Research in Fundamental Sciences (IPM), P. O. Box 19395-5531, Tehran (Iran, Islamic Republic of); Wang, Yi, E-mail: Xingang.Chen@utdallas.edu, E-mail: emami@ipm.ir, E-mail: firouz@ipm.ir, E-mail: yw366@cam.ac.uk [Centre for Theoretical Cosmology, DAMTP, University of Cambridge, Cambridge CB3 0WA (United Kingdom)

    2014-08-01

    The ongoing and future experiments will measure the B-mode from different sky coverage and frequency bands, with the potential to reveal non-trivial features in polarization map. In this work we study the TT, TB, EB and BB correlations associated with the B-mode polarization of CMB map in models of charged anisotropic inflation. The model contains a chaotic-type large field complex inflaton which is charged under the U(1) gauge field. We calculate the statistical anisotropies generated in the power spectra of the curvature perturbation, the tensor perturbation and their cross-correlation. It is shown that the asymmetry in tensor power spectrum is a very sensitive probe of the gauge coupling. While the level of statistical anisotropy in temperature power spectrum can be small and satisfy the observational bounds, the interactions from the gauge coupling can induce large directional dependence in tensor modes. This will leave interesting anisotropic fingerprints in various correlations involving the B-mode polarization such as the TB cross-correlation which may be detected in upcoming Planck polarization data. In addition, the TT correlation receives an anisotropic contribution from the tensor sector which naturally decays after l ∼> 100. We expect that the mechanism of using tensor sector to induce asymmetry at low l to be generic which can also be applied to address other low l CMB anomalies.

  1. Trash to Gas (TtG) Simulant Analysis

    Science.gov (United States)

    Miles, John D., II; Hintze, Paul E.

    2014-01-01

    Space exploration in outer earths orbit is a long-term commitment, where the reuse of discarded materials is a critical component for its success. The Logistics Reduction and Repurposing (LRR) project under the NASA Advanced Exploration System Program is a project focused on technologies that reduce the amount of consumables that are needed to be sent into space, repurpose items sent to space, or convert wastes to commodities. In particular, Trash to Gas (TtG), part of the LRR project, is a novel space technology capable of converting raw elements from combustible waste including food waste and packaging, paper, wipes and towels, nitrile gloves, fecal matter, urine brine, maximum absorbency garments, and other organic wastes from human space exploration into useful gases. Trash to gas will ultimately reduce mission cost by producing a portion of important consumables in situ. This paper will discuss results of waste processing by steam reforming. Steam reforming is a thermochemical process developed as part of TtG, where waste is heated in the presence of oxygen and steam to produce carbon dioxide, carbon monoxide, hydrogen, methane and water. The aim of this experiment is to investigate the processing of different waste simulants and their gaseous products. This will lay a foundation for understating and optimizing the production of useful gases for propulsion and recovery of water for life support.

  2. Search for Dileptonic ttH(H->bb) with the ATLAS Detector

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00403960

    A search for the Higgs boson produced in association with a pair of top quarks ttH is presented. The analysis uses 13.2 fb$^{-1}$ of proton-proton collision data with a centre of mass energy of 13 TeV, collected by the ATLAS experiment at the LHC in 2015 and 2016. The search is optimised for events in which the top quarks decay into electrons or muons and the Higgs boson decays into bottom quarks. The analysis proceeds by separating the events into categories determined by the number of jets present in the event, and the number of those jets which are identified as originating from bottom hadrons. Multivariate techniques are used in the most signal rich regions to provide optimal separation between the signal and background processes. Finally, a template likelihood fit is performed simultaneously across all the regions, constraining the uncertainties on the analysis and determining the most likely value for the production cross section of ttH. The search found the best fit production cross section to be $4.6^...

  3. Multivariate Identification of Background Contributions for the H ! tt

    CERN Document Server

    Andrejkovic, Janik Walter

    2016-01-01

    Within the H ! tt analysis it is very important to understand the background contamination in the signal region coming from events where a jet is misidentified as a hadronic tau (fake events). Currently, the fake rate method is used to estimate the number and distributions of fake events in the signal region. This method relies on the correct identification of different background types. The study presented in this report focuses on the use of boosted decision trees in order to identify different background types. It is shown how the addition of more input variables, leading to a multi-dimensional multi-classification task, improves the overall identification accuracy of the different background types.

  4. Design and realization of a novel multitask TT&C operation pattern

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    With the sharp increase of China's in-orbit spacecraft and the constraint TT&C resources, a mathematical model for optimal TT&C resource allocation is proposed, and the TT&C facility remote monitoring function is designed to achieve the multitask operation pattern under the unified management of the network management center. With this pattern, the TT&C network management and the spacecraft management are separated, which is quite different from the previous pattern. Further, a novel spacecraft TT&C technique based on spacecraft control language is developed, and the telecommanding pattern is designed to address the spacecraft operation problems. The engineering application shows that this pattern fundamentally improves the TT&C network capability, increases the resource efficiency, and satisfies the efficient, accurate, and flexible operation of spacecraft.

  5. The metabolic and performance effects of caffeine compared to coffee during endurance exercise.

    Science.gov (United States)

    Hodgson, Adrian B; Randell, Rebecca K; Jeukendrup, Asker E

    2013-01-01

    There is consistent evidence supporting the ergogenic effects of caffeine for endurance based exercise. However, whether caffeine ingested through coffee has the same effects is still subject to debate. The primary aim of the study was to investigate the performance enhancing effects of caffeine and coffee using a time trial performance test, while also investigating the metabolic effects of caffeine and coffee. In a single-blind, crossover, randomised counter-balanced study design, eight trained male cyclists/triathletes (Mean ± SD: Age 41 ± 7 y, Height 1.80 ± 0.04 m, Weight 78.9 ± 4.1 kg, VO2 max 58 ± 3 ml • kg(-1) • min(-1)) completed 30 min of steady-state (SS) cycling at approximately 55% VO2max followed by a 45 min energy based target time trial (TT). One hour prior to exercise each athlete consumed drinks consisting of caffeine (5 mg CAF/kg BW), instant coffee (5 mg CAF/kg BW), instant decaffeinated coffee or placebo. The set workloads produced similar relative exercise intensities during the SS for all drinks, with no observed difference in carbohydrate or fat oxidation. Performance times during the TT were significantly faster (~5.0%) for both caffeine and coffee when compared to placebo and decaf (38.35 ± 1.53, 38.27 ± 1.80, 40.23 ± 1.98, 40.31 ± 1.22 min respectively, pperformance times were similar for both caffeine and coffee. Average power for caffeine and coffee during the TT was significantly greater when compared to placebo and decaf (294 ± 21 W, 291 ± 22 W, 277 ± 14 W, 276 ± 23 W respectively, pcaffeine (5 mg/kg/BW) and coffee (5 mg/kg/BW) consumed 1 h prior to exercise can improve endurance exercise performance.

  6. Developing a SAR TT-OSL protocol for volcanically-heated aeolian quartz from Datong (China)

    DEFF Research Database (Denmark)

    Liu, Jinfeng; Murray, Andrew S.; Jain, Mayank

    2012-01-01

    The thermally-transferred optically stimulated luminescence (TT-OSL) responses of chemically-purified fine-grained quartz from a lava-baked aeolian sediment from Datong (China) are presented. Our main focus is to examine the suitability of the test dose TT-OSL and OSL response to monitor sensitiv......The thermally-transferred optically stimulated luminescence (TT-OSL) responses of chemically-purified fine-grained quartz from a lava-baked aeolian sediment from Datong (China) are presented. Our main focus is to examine the suitability of the test dose TT-OSL and OSL response to monitor...

  7. Lap time simulation and design optimisation of a brushed DC electric motorcycle for the Isle of Man TT Zero Challenge

    Science.gov (United States)

    Dal Bianco, N.; Lot, R.; Matthys, K.

    2018-01-01

    This works regards the design of an electric motorcycle for the annual Isle of Man TT Zero Challenge. Optimal control theory was used to perform lap time simulation and design optimisation. A bespoked model was developed, featuring 3D road topology, vehicle dynamics and electric power train, composed of a lithium battery pack, brushed DC motors and motor controller. The model runs simulations over the entire ? or ? of the Snaefell Mountain Course. The work is validated using experimental data from the BX chassis of the Brunel Racing team, which ran during the 2009 to 2015 TT Zero races. Optimal control is used to improve drive train and power train configurations. Findings demonstrate computational efficiency, good lap time prediction and design optimisation potential, achieving a 2 minutes reduction of the reference lap time through changes in final drive gear ratio, battery pack size and motor configuration.

  8. Mental Fatigue Alters Cortical Activation and Psychological Responses, Impairing Performance in a Distance-Based Cycling Trial

    Directory of Open Access Journals (Sweden)

    Flávio O. Pires

    2018-03-01

    Full Text Available Purpose: We sought to verify if alterations in prefrontal cortex (PFC activation and psychological responses would play along with impairments in pacing and performance of mentally fatigued cyclists.Materials and Methods: Eight recreational cyclists performed two preliminary sessions to familiarize them with the rapid visual information processing (RVP test, psychological scales and 20 km cycling time trial (TT20km (session 1, as well as to perform a VO2MAX test (session 2. Thereafter, they performed a TT20km either after a RVP test (30 min or a time-matched rest control session (session 3 and 4 in counterbalanced order. Performance and psychological responses were obtained throughout the TT20km while PFC electroencephalography (EEG was obtained at 10 and 20 km of the TT20km and throughout the RVP test. Increases in EEG theta band power indicated a mental fatigue condition. Repeated-measures mixed models design and post-hoc effect size (ES were used in comparisons.Results: Cyclists completed the trial ~2.7% slower in mental fatigue (34.3 ± 1.3 min than in control (33.4 ± 1.1 min, p = 0.02, very large ES, with a lower WMEAN (224.5 ± 17.9 W vs. 240.2 ± 20.9 W, respectively; p = 0.03; extremely large ES. There was a higher EEG theta band power during RVP test (p = 0.03; extremely large ES, which remained during the TT20km (p = 0.01; extremely large ES. RPE increased steeper in mental fatigue than in control, together with isolated reductions in motivation at 2th km (p = 0.04; extremely large ES, felt arousal at the 2nd and 4th km (p = 0.01; extremely large ES, and associative thoughts to exercise at the 6th and 16th km (p = 0.02; extremely large ES of the TT20km.Conclusions: Mentally fatigued recreational cyclists showed impaired performance, altered PFC activation and faster increase in RPE during a TT20km.

  9. Effect of beta-alanine, with and without sodium bicarbonate, on 2000-m rowing performance.

    Science.gov (United States)

    Hobson, Ruth M; Harris, Roger C; Martin, Dan; Smith, Perry; Macklin, Ben; Gualano, Bruno; Sale, Craig

    2013-10-01

    To examine the effect of beta-alanine only and beta-alanine with sodium bicarbonate supplementation on 2,000-m rowing performance. Twenty well-trained rowers (age 23 ± 4 y; height 1.85 ± 0.08 m; body mass 82.5 ± 8.9 kg) were assigned to either a placebo or beta-alanine (6.4 g · d(-1) for 4 weeks) group. A 2,000-m rowing time trial (TT) was performed before supplementation (Baseline) and after 28 and 30 days of supplementation. The post supplementation trials involved supplementation with either maltodextrin or sodium bicarbonate in a double-blind, crossover design, creating four study conditions (placebo with maltodextrin; placebo with sodium bicarbonate; beta-alanine with maltodextrin; beta-alanine with sodium bicarbonate). Blood lactate, pH, bicarbonate, and base excess were measured pre-TT, immediately post-TT and at TT+5 min. Performance data were analyzed using magnitude based inferences. Beta-alanine supplementation was very likely to be beneficial to 2,000-m rowing performance (6.4 ± 8.1 s effect compared with placebo), with the effect of sodium bicarbonate having a likely benefit (3.2 ± 8.8 s). There was a small (1.1 ± 5.6 s) but possibly beneficial additional effect when combining chronic beta-alanine supplementation with acute sodium bicarbonate supplementation compared with chronic beta-alanine supplementation alone. Sodium bicarbonate ingestion led to increases in plasma pH, base excess, bicarbonate, and lactate concentrations. Both chronic beta-alanine and acute sodium bicarbonate supplementation alone had positive effects on 2,000-m rowing performance. The addition of acute sodium bicarbonate to chronic beta-alanine supplementation may further enhance rowing performance.

  10. Dispelling the myth that habitual caffeine consumption influences the performance response to acute caffeine supplementation.

    Science.gov (United States)

    Gonçalves, Lívia de Souza; Painelli, Vitor de Salles; Yamaguchi, Guilherme; Oliveira, Luana Farias de; Saunders, Bryan; da Silva, Rafael Pires; Maciel, Erika; Artioli, Guilherme Giannini; Roschel, Hamilton; Gualano, Bruno

    2017-07-01

    This study investigates the influence of habitual caffeine intake on aerobic exercise-performance responses to acute caffeine supplementation. A double-blind, crossover, counterbalanced study was performed. Forty male endurance-trained cyclists were allocated into tertiles, according to their daily caffeine intake: low (58 ± 29 mg/d), moderate (143 ± 25 mg/d), and high (351 ± 139 mg/d) consumers. Participants completed three trials in which they performed simulated cycling time trials (TTs) in the fastest time possible following ingestion of the following: caffeine (CAF: 6 mg/kg body mass), placebo (PLA), and no supplement (CON). A mixed-model analysis revealed that TT performance was significantly improved in CAF compared with PLA and CON (29.92 ± 2.18 vs. 30.81 ± 2.67 and 31.14 ± 2.71 min, respectively; P = 0.0002). Analysis of covariance revealed no influence of habitual caffeine intake as a covariate on exercise performance ( P = 0.47). TT performance was not significantly different among tertiles ( P = 0.75). No correlation was observed between habitual caffeine intake and absolute changes (CAF - CON) in TT performance with caffeine ( P = 0.524). Individual analysis showed that eight, seven, and five individuals improved above the variation of the test in CAF in the low, moderate, and high tertiles, respectively. A Fisher's exact test did not show any significant differences in the number of individuals who improved in CAF among the tertiles ( P > 0.05). Blood lactate and ratings of perceived exertion were not different between trials and tertiles ( P > 0.05). Performance effects of acute caffeine supplementation during an ~30-min cycling TT performance were not influenced by the level of habitual caffeine consumption. NEW & NOTEWORTHY There has been a long-standing paradigm that habitual caffeine intake may influence the ergogenicity of caffeine supplementation. Low, moderate, and high caffeine consumers showed similar absolute and

  11. 26th Conference of Spacecraft TT&C Technology in China

    CERN Document Server

    Qian, Weiping

    2013-01-01

    Proceedings of the 26th Conference of Spacecraft TT&C Technology in China collects selected papers from the 26th Conference of Spacecraft TT&C Technology in China held in Nanjing on October 16-19, 2012. The book features state-of-the-art studies on spacecraft TT&C in China with the theme of “Shared and Flexible TT&C Systems”. The selected works can help  promote development of spacecraft TT&C technology towards interconnectivity, resource sharing, flexibility and high efficiency. Researchers and engineers in the field of aerospace engineering and communication engineering can benefit from the book. Rongjun Shen is the Academician of Chinese Academy of Engineering; Weiping Qian is the Director General of Beijing Institute of Tracking and Telecommunications Technology.

  12. Recovery from a cycling time trial is enhanced with carbohydrate-protein supplementation vs. isoenergetic carbohydrate supplementation

    Directory of Open Access Journals (Sweden)

    Lemon Peter WR

    2008-12-01

    Full Text Available Abstract Background In this study we assessed whether a liquid carbohydrate-protein (C+P supplement (0.8 g/kg C; 0.4 g/kg P ingested early during recovery from a cycling time trial could enhance a subsequent 60 min effort on the same day vs. an isoenergetic liquid carbohydrate (CHO supplement (1.2 g/kg. Methods Two hours after a standardized breakfast, 15 trained male cyclists completed a time trial in which they cycled as far as they could in 60 min (AMex using a Computrainer indoor trainer. Following AMex, subjects ingested either C+P, or CHO at 10, 60 and 120 min, followed by a standardized meal at 4 h post exercise. At 6 h post AMex subjects repeated the time trial (PMex. Results There was a significant reduction in performance for both groups in PMex versus AMex. However, performance and power decreases between PMex and AMex were significantly greater (p ≤ 0.05 with CHO (-1.05 ± 0.44 km and -16.50 ± 6.74 W vs C+P (-0.30 ± 0.50 km and -3.86 ± 6.47 W. Fat oxidation estimated from RER values was significantly greater (p ≤ 0.05 in the C+P vs CHO during the PMex, despite a higher average workload in the C+P group. Conclusion Under these experimental conditions, liquid C+P ingestion immediately after exercise increases fat oxidation, increases recovery, and improves subsequent same day, 60 min efforts relative to isoenergetic CHO ingestion.

  13. Effect of a 5-min cold-water immersion recovery on exercise performance in the heat.

    Science.gov (United States)

    Peiffer, J J; Abbiss, C R; Watson, G; Nosaka, K; Laursen, P B

    2010-05-01

    This study examined the effect of a 5-min cold-water immersion (14 degrees C) recovery intervention on repeated cycling performance in the heat. 10 male cyclists performed two bouts of a 25-min constant-paced (254 (22) W) cycling session followed by a 4-km time trial in hot conditions (35 degrees C, 40% relative humidity). The two bouts were separated by either 15 min of seated recovery in the heat (control) or the same condition with 5-min cold-water immersion (5th-10th minute), using a counterbalanced cross-over design (CP(1)TT(1) --> CWI or CON --> CP(2)TT(2)). Rectal temperature was measured immediately before and after both the constant-paced sessions and 4-km timed trials. Cycling economy and Vo(2) were measured during the constant-paced sessions, and the average power output and completion times were recorded for each time trial. Compared with control, rectal temperature was significantly lower (0.5 (0.4) degrees C) in cold-water immersion before CP(2) until the end of the second 4-km timed trial. However, the increase in rectal temperature (0.5 (0.2) degrees C) during CP(2) was not significantly different between conditions. During the second 4-km timed trial, power output was significantly greater in cold-water immersion (327.9 (55.7) W) compared with control (288.0 (58.8) W), leading to a faster completion time in cold-water immersion (6.1 (0.3) min) compared with control (6.4 (0.5) min). Economy and Vo(2) were not influenced by the cold-water immersion recovery intervention. 5-min cold-water immersion recovery significantly lowered rectal temperature and maintained endurance performance during subsequent high-intensity exercise. These data indicate that repeated exercise performance in heat may be improved when a short period of cold-water immersion is applied during the recovery period.

  14. Nueva escuela elemental, en Eichstätt

    Directory of Open Access Journals (Sweden)

    HaindlEditorial, Friederich F.

    1963-02-01

    Full Text Available A modem elementary school has been built over part of the old moat at Eichstätt. The diferences in level of the ground have been exploited in order to achieve a more interesting distribution of the school buildings. The main building is L shaped. It contains 11 classrooms, workshops and a large recreation hall, which are located within the ground floor of one of the wings. The other wing includes the management's staircase, special classrooms, the hall porter's quarters and heating installations. Near the main building there is another block housing four classrooms, and both buildings are separated by a recreation ground, and connected by a roofed path. A further block, nearby, contains the gymnasium. There is direct access from the street to this building. The foundations consist of concrete piles, supported laterally by means of reinforced concrete beams. The floor and staircase structure is also made of reinforced concrete, and the roof is covered with fibrocement sheeting. The clever distribution of the inner courtyards, which are to be decorated with small gardens, the emplacement of the building in the moat, and the powerful contrast between the old city wall and the new buildings give the project a charming quality within the urban background, which also helps to emphasize even more the interest of the historical monuments.Una moderna escuela elemental ha sido construida sobre parte del viejo foso de la ciudad de Eichstätt, aprovechando para disponer los diversos bloques, las posibilidades que ofrecen los desniveles del terreno. La construcción principal —con planta en forma de L — contiene 11 clases, talleres y una gran nave para el recreo, situada en el piso inferior en uno de los brazos. En el otro están: la escalera de dirección, clases especiales, conserjería y vivienda del conserje e instalación de calefacción. Junto al edificio principal hay un bloque de cuatro clases, separado por un patio de recreo y enlazado por

  15. Low and moderate doses of caffeine late in exercise improve performance in trained cyclists.

    Science.gov (United States)

    Talanian, Jason L; Spriet, Lawrence L

    2016-08-01

    The aim of the present study was to assess if low and moderate doses of caffeine delivered in a carbohydrate-electrolyte solution (CES) late in exercise improved time-trial (TT) performance. Fifteen (11 male, 4 female) cyclists (age, 22.5 ± 0.9 years; body mass, 69.3 ± 2.6 kg; peak oxygen consumption, 64.6 ± 1.9 mL·min(-1)·kg(-1)) completed 4 double-blinded randomized trials. Subjects completed 120 min of cycling at ∼60% peak oxygen consumption with 5 interspersed 120-s intervals at ∼82% peak oxygen consumption, immediately followed by 40-s intervals at 50 W. Following 80 min of cycling, subjects either ingested a 6% CES (PL), a CES with 100 mg (low dose, 1.5 ± 0.1 mg·kg body mass(-1)) of caffeine (CAF1), or a CES with 200 mg (moderate dose, 2.9 ± 0.1 mg·kg body mass(-1)) of caffeine (CAF2). Following the 120-min cycling challenge, cyclists completed a 6-kJ·kg body mass(-1) TT. There was no difference between respiratory, heart rate, glucose, free fatty acid, body mass, hematocrit, or urine specific gravity measurements between treatments. The CAF2 (26:36 ± 0:22 min:s) TT was completed faster than CAF1 (27:36 ± 0:32 min:s, p caffeine delivered late in exercise improved TT performance over the PL trial and the moderate dose (CAF2) improved performance to a greater extent than the low dose (CAF1).

  16. Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test

    DEFF Research Database (Denmark)

    Gjesing, A P; Kjems, L L; Vestmar, M A

    2011-01-01

    , proinsulin, insulin, C-peptide, glucagon, glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2) and gastric inhibitory polypeptide (GIP) among individuals carrying the high-risk rs7903146 TT genotype and low-risk CC genotype following a meal test. Methods A meal challenge was performed in 31......, 45, 60, 75, 90, 105, 120, 135, 150, 180, 210, and 240 min after ingestion of a standardised breakfast meal. Results An elevated incremental AUC for plasma glucose was observed among TT genotype carriers (CC carriers 21.8¿±¿101.9 mmol/l¿×¿min vs TT carriers 97.9¿±¿89.2 mmol/l¿×¿min, p¿=¿0.001). TT...

  17. TtMCO: A highly thermostable laccase-like multicopper oxidase from the thermophilic Thermobaculum terrenum

    DEFF Research Database (Denmark)

    Brander, Søren; Mikkelsen, Jørn Dalgaard; Kepp, Kasper Planeta

    2015-01-01

    This paper reports the identification, heterologous expression in Escherichia coli and characterization of TtMCO from the thermophilic bacterium Thermobaculum terrenum, the first laccase-like multi-copper oxidase (LMCO) from the distinct Phylum Chloroflexi. TtMCO has only 39% identity to its...... closest characterized homologue, CotA from Bacillus subtilis, but sequence and spectrophotometry confirmed copper coordination similar to that of LMCOs. TtMCO is extremely thermophilic with a half-time of inactivation of 2.24 days at 70 degrees C and 350 min at 80°C and pH 7, consistent...

  18. Do Glucose and Caffeine Nasal Sprays Influence Exercise or Cognitive Performance?

    Science.gov (United States)

    De Pauw, Kevin; Roelands, Bart; Van Cutsem, Jeroen; Decroix, Lieselot; Valente, Angelica; Taehee, Kim; Lettan, Robert B; Carrillo, Andres E; Meeusen, Romain

    2017-10-01

    Nasal spray (NAS) containing caffeine (CAF) or glucose (GLUC) activates sensory(motor) cortices. To investigate the influence of CAF or GLUC NAS on exercise and cognitive performance. Eleven male subjects (age 22 ± 2 y) performed a maximal cycle test and 2 familiarization and 3 experimental trials. Each trial included a 30-s Wingate test and a 30-min time-trial (TT) performance test interspersed by 15 min of rest. Before and after each exercise test a Stroop task was conducted. Placebo NAS with or without CAF or GLUC was provided before each exercise session and at each completed 25% of the TT. Exercise-performance, physiological, and cognitive measures were obtained. Magnitude-based inferences determined the likelihood that NAS solutions would be beneficial, trivial, or negative to exercise-performance measures based on the smallest worthwhile effect. Physiological and cognitive measures were analyzed using (non)parametric tests (P performance enhancements were found for both substances. In addition, no significant differences in physiological and cognitive measures were observed. In line with mouth rinsing, GLUC was shown to substantially enhance endurance performance, probably due to the activation of the olfactory pathway and/or extra-oral sweet-taste receptors. GLUC NAS enhances endurance performance, which indicates a novel administration route. The higher activity in sensory brain cortices probably elicited the ergogenic effect. However, no further physiological and cognitive changes occurred, indicating that higher doses of substrates might be required.

  19. Comparação entre desempenhos de corrida time trial realizados em pista e esteira

    Directory of Open Access Journals (Sweden)

    Cecília Segabinazi Peserico

    2014-05-01

    Poucos estudos verificaram a influência do ambiente de teste (campo e laboratório sobre o ritmo de corrida e variáveis fisiológicas obtidas durante o desempenho em corrida de endurance. Portanto, o objetivo deste estudo foi comparar o comportamento da velocidade média (VM, ritmo de corrida, frequência cardíaca (FC e percepção subjetiva de esforço (PSE obtidas durante os desempenhos de corrida em provas time trial de uma hora realizados em pista de atletismo e em esteira. Dezoito homens corredores recreacionais (25,4 ± 3,3 anos realizaram duas performances de uma hora de corrida: uma em esteira e outra em pista de atletismo de 400 m. A PSE e a FC foram registradas a cada 10 minutos, e a VM a cada 15 minutos para a determinação do ritmo de corrida. As variáveis relacionadas aos desempenhos foram comparadas pelo teste t de Student para amostras pareadas. Os valores de VM, FC e PSE obtidos durante diferentes momentos das provas foram comparados pela Anova de dois fatores para medidas repetidas seguido do post hoc de Bonferroni. Para todas as análises, foi adotado nível de significância de P< 0,05. A VM da prova realizada em pista (12,2 ± 0,8 km·h-1 foi superior à prova em esteira (11,8 ± 0,8 km·h-1. Além disso, foram encontradas diferenças entre os dois desempenhos para os valores de frequência cardíaca média e máxima, e para o ritmo de corrida. A partir dessas diferenças, conclui-se que os desempenhos foram influenciados pelo ambiente onde as provas de uma hora foram realizadas.

  20. First measurement of the tt[over ] differential cross section dsigma/dM_{tt[over ]} in pp[over ] collisions at sqrt[s]=1.96 TeV.

    Science.gov (United States)

    Aaltonen, T; Adelman, J; Akimoto, T; Alvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzurri, P; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Bartsch, V; Bauer, G; Beauchemin, P-H; Bedeschi, F; Beecher, D; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Beringer, J; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burke, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Calancha, C; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Chwalek, T; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Compostella, G; Convery, M E; Conway, J; Cordelli, M; Cortiana, G; Cox, C A; Cox, D J; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; Dagenhart, D; Datta, M; Davies, T; de Barbaro, P; De Cecco, S; Deisher, A; De Lorenzo, G; Dell'orso, M; Deluca, C; Demortier, L; Deng, J; Deninno, M; Derwent, P F; di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Elagin, A; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; Garcia, J E; Garfinkel, A F; Genser, K; Gerberich, H; Gerdes, D; Gessler, A; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C M; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Han, B-Y; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hays, C; Heck, M; Heijboer, A; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Husemann, U; Hussein, M; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jha, M K; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Kar, D; Karchin, P E; Kato, Y; Kephart, R; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, H W; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Knuteson, B; Ko, B R; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhr, T; Kulkarni, N P; Kurata, M; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecompte, T; Lee, E; Lee, H S; Lee, S W; Leone, S; Lewis, J D; Lin, C-S; Linacre, J; Lindgren, M; Lipeles, E; Liss, T M; Lister, A; Litvintsev, D O; Liu, C; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Lovas, L; Lucchesi, D; Luci, C; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Macqueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Marino, C P; Martin, A; Martin, V; Martínez, M; Martínez-Ballarín, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Mathis, M; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzione, A; Merkel, P; Mesropian, C; Miao, T; Miladinovic, N; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moggi, N; Moon, C S; Moore, R; Morello, M J; Morlock, J; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Nett, J; Neu, C; Neubauer, M S; Neubauer, S; Nielsen, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Osterberg, K; Pagan Griso, S; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Peiffer, T; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Pueschel, E; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Renton, P; Renz, M; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Rutherford, B; Saarikko, H; Safonov, A; Sakumoto, W K; Saltó, O; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savoy-Navarro, A; Schlabach, P; Schmidt, A; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sforza, F; Sfyrla, A; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shiraishi, S; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakyan, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spreitzer, T; Squillacioti, P; Stanitzki, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Strycker, G L; Stuart, D; Suh, J S; Sukhanov, A; Suslov, I; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Thom, J; Thompson, A S; Thompson, G A; Thomson, E; Tipton, P; Ttito-Guzmán, P; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Tourneur, S; Trovato, M; Tsai, S-Y; Tu, Y; Turini, N; Ukegawa, F; Vallecorsa, S; van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Vidal, M; Vidal, R; Vila, I; Vilar, R; Vine, T; Vogel, M; Volobouev, I; Volpi, G; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wagner-Kuhr, J; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Weinelt, J; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Wilbur, S; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Würthwein, F; Xie, S; Yagil, A; Yamamoto, K; Yamaoka, J; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zhang, X; Zheng, Y; Zucchelli, S

    2009-06-05

    We present a measurement of the tt[over ] differential cross section with respect to the tt[over ] invariant mass, dsigma/dM_{tt[over ]}, in pp[over ] collisions at sqrt[s]=1.96 TeV using an integrated luminosity of 2.7 fb;{-1} collected by the CDF II experiment. The tt[over ] invariant mass spectrum is sensitive to a variety of exotic particles decaying into tt[over ] pairs. The result is consistent with the standard model expectation, as modeled by PYTHIA with CTEQ5L parton distribution functions.

  1. 31 CFR 203.5 - Designation of financial institutions as TT&L depositaries.

    Science.gov (United States)

    2010-07-01

    ... PAYMENT OF FEDERAL TAXES AND THE TREASURY TAX AND LOAN PROGRAM General Information § 203.5 Designation of... authorized to maintain a TT&L account, TIP main account balance, SDI account balance, or TIO account balance...

  2. EM Modeling of Far-Field Radiation Patterns for Antennas on the GMA-TT UAV

    Science.gov (United States)

    Mackenzie, Anne I.

    2015-01-01

    To optimize communication with the Generic Modular Aircraft T-Tail (GMA-TT) unmanned aerial vehicle (UAV), electromagnetic (EM) simulations have been performed to predict the performance of two antenna types on the aircraft. Simulated far-field radiation patterns tell the amount of power radiated by the antennas and the aircraft together, taking into account blockage by the aircraft as well as radiation by conducting and dielectric portions of the aircraft. With a knowledge of the polarization and distance of the two communicating antennas, e.g. one on the UAV and one on the ground, and the transmitted signal strength, a calculation may be performed to find the strength of the signal travelling from one antenna to the other and to check that the transmitted signal meets the receiver system requirements for the designated range. In order to do this, the antenna frequency and polarization must be known for each antenna, in addition to its design and location. The permittivity, permeability, and geometry of the UAV components must also be known. The full-wave method of moments solution produces the appropriate dBi radiation pattern in which the received signal strength is calculated relative to that of an isotropic radiator.

  3. 9th Transgenic Technology Meeting (TT2010) in Berlin, Germany: a meeting report.

    Science.gov (United States)

    Saunders, Thomas L; Sobieszczuk, Peter

    2010-12-01

    The first Transgenic Technology (TT) Meeting was organized in 1999 by Johannes Wilbertz, Karolinska Institute, Stockholm, Sweden as a regional meeting. The TT Meetings continued in this way, constantly gathering additional practitioners of transgenic methodologies until the breakthrough in 2005 when the 6th TT Meeting in Barcelona, Spain, hosted by Lluis Montoliu (Centro Nacional de Biotecnologia, Madrid, Spain), generated the momentum to establish the International Society for Transgenic Technologies (ISTT). Since 2006, the ISTT has continued to promote the TT Meetings and provide its membership with a forum to discuss best practices and new methods in the field. The TT2010 Meeting was held at the Max Delbrück Center for Molecular Medicine (Berlin, Germany). Participation at the TT2010 Meeting exceeded the registration capacity and set a new attendance record. Session topics included methods for the generation of rat and mouse models of human disease, fundamental and advanced topics in rodent embryonic stem cells, and the newest transgenic technologies. Short presentations from selected abstracts were of especial interest. Roundtable discussions on transgenic facility establishment and cryoarchiving of mouse lines were favorably received. Students, technical staff, and professors participated in numerous discussions and came away with practical methods and new ideas for research.

  4. Characterization of Biosurfactant Produced by Bacillus licheniformis TT42 Having Potential for Enhanced Oil Recovery.

    Science.gov (United States)

    Suthar, Harish; Nerurkar, Anuradha

    2016-09-01

    Bacillus licheniformis TT42 produced a low-molecular weight anionic biosurfactant that reduced the surface tension of water from 72 to 27 mN/m and the interfacial tension from 12 to 0.05 mN/m against crude oil. We have earlier reported significant enhancement in oil recovery in laboratory sand pack columns and core flood studies, by biosurfactant-TT42 compared to standard strain, Bacillus mojavensis JF2. In the context of this application of the biosurfactant-TT42, its characterization was deemed important. In the preliminary studies, the biosurfactant-TT42 was found to be functionally stable at under conditions of temperature, pH, and salinity generally prevalent in oil reservoirs. Furthermore, the purified biosurfactant-TT42 was found to have a CMC of 22 mg/l. A newly developed activity staining TLC method was used for the purification of biosurfactant-TT42. Structural characterization of biosurfactant-TT42 using TLC, Fourier transform infrared spectroscopy (FTIR), GC-MS, and matrix-assisted laser desorption ionization time of flight (MALDI-TOF)/TOF suggested that it was a mixture of lipopeptide species, all having a common hydrophilic cyclic heptapeptide head with the sequence, Gln-Leu/Ileu-Leu/Ileu-Val-Asp-Leu/Ileu-Leu/Ileu linked to hydrophobic tails of different lengths of 3β-OH-fatty acids bearing 1043, 1057 and 1071 Da molecular weight, where 3β-OH-C19 fatty acid was predominant. This is the longest chain length of fatty acids reported in a lipopeptide.

  5. Stress corrosion cracking growth rate of TT alloy 690 and its weld joint in simulated PWR primary water

    International Nuclear Information System (INIS)

    Yonezawa, T.

    2015-01-01

    Recently, some researchers reported that the SCC growth rate (SCCGR) of cold worked thermally treated (TT) Alloy 690 was significantly different in heat by heat. But, author has hypothesized that these high SCCGRs in cold worked TT Alloy 690 could be due to the metallurgical characteristics of these heats. In order to confirm this hypothesis, this study has been started in the author's laboratory, and the following 4 new evidences were obtained. First, microcracks of carbides and voids were observed in eutectic M 23 C 6 GB carbides (primary carbides) for cold rolled laboratory heat after as cast or lightly forged condition or for chemical composition simulated Bettis'TT Alloy 690 heat, after cold rolling, before SCC test. However, microcracks in primary carbides along grain boundaries and voids were rarely detected in the cold rolled commercial heat of TT Alloy 690 used for CRDM penetrations. Secondly, the SCCGR observed in TT Alloy 690 was different in each hot working process and each heat. Comparing the SCCGRs for all heats of cold worked TT Alloy 690, the SCCGR decreased with increasing of Vickers hardness. However, in same heats of cold worked TT Alloy 690, the SCCGR increased with increasing of Vickers hardness. Thirdly, the SCCGR in cold rolled TT Alloy 690 should be integrated by the effect of hardness or cold working ratio and by the effect of existing ratio of primary M23C6 carbides with cracks and Voids due to chemical composition and the fabrication process of TT Alloy 690. Fourthly, it is argued that the high SCCGRs in highly cold rolled TT Alloy 690 are not representative of the practical situation with TT Alloy 690 in service for CRDM adapter nozzles etc. The high SCCGR of highly cold rolled TT Alloy 690 is not thought to be an accurate tool in predicting the possibility of cracking of TT Alloy 690 for CRDM adapter nozzles. (author)

  6. IGA resistance of TT Alloy 690 and concentration behavior of Broached Egg Crate tube support configuration

    International Nuclear Information System (INIS)

    Suzuki, S.; Kusakabe, T.; Yamamoto, H.; Arioka, K.; Ochi, T.

    1992-01-01

    In order to improve the reliability of the Steam Generator (SG), TT Alloy 690 and BEC (Broached Egg Crate) type tube support plate has been developed. Some tests are carried out to heighten the reliability for these improvements all the more and the following results are obtained. (1) SERT test (Slow Extension Rate Test) made clear that TT690 has less IGA susceptibility in comparison with MA600. (2) The alkaline susceptibility on the occurrence of IGA/SCC on TT690 and MA600 obtained by SERT corresponds to that obtained by Model Boiler test. (3) By model boiler test, superior concentration behaviors for BEC type tube support plate configuration have been recognized in comparison with Drill type. This result is obtained by the joint research of the five utilities (Kansai Epco, Hokkaido Epco, Shikoku Epco, Kyushu Epco, JAPCO) and MHI

  7. Poster - Thurs Eve-16: Just-in-time tomography (JiTT).

    Science.gov (United States)

    Pang, G; Rowlands, J A

    2008-07-01

    Soft-tissue target motion is one of the main concerns in high-precision radiation therapy. Cone beam computed tomography (CBCT) has been developed recently to image soft-tissue targets in the treatment room for image-guided radiation therapy. However, due to its relatively long image acquisition time the CBCT approach cannot provide images of the target at the instant of the treatment and thus is not adequate for imaging targets with intrafraction motion. In this work, a new concept for image-guided radiation therapy- just-in-time tomography (JiTT) - is introduced. Differing from CBCT, JiTT takes much less time to generate the needed tomographical, beam's-eye-view images of the treatment target at the right moment to guide the radiation therapy treatment. A system to achieve JiTT is proposed and its feasibility is investigated. Research supported by Siemens. © 2008 American Association of Physicists in Medicine.

  8. Tunteettomuudesta tunteeseen : Apatian ilmaisu ja tunteen herättäminen maalausprosessissa

    OpenAIRE

    Gellman, Karin

    2014-01-01

    Miten teos ilmaisee tunnetta? Miltä apatia näyttää? Mikä merkitys tunteen herättämisellä on taiteen tekemisen ulkopuolella? Teoreettisena lähtökohtana toimiva R. G. Collingwoodin psykodynaaminen ilmaisuteoria valaisee tietoisuuden suhdetta tunteen herättämisen mekanismeihin maalausprosessin näkökulmasta. How does a work of art express emotion? What does apathy look like? What significance does the craft of arousing emotion have outside the context of artmaking? Psychodynamic perspective i...

  9. Regulation of anthocyanin and proanthocyanidin biosynthesis by Medicago truncatula bHLH transcription factor MtTT8.

    Science.gov (United States)

    Li, Penghui; Chen, Beibei; Zhang, Gaoyang; Chen, Longxiang; Dong, Qiang; Wen, Jiangqi; Mysore, Kirankumar S; Zhao, Jian

    2016-05-01

    The MYB- basic helix-loop-helix (bHLH)-WD40 complexes regulating anthocyanin and proanthocyanidin (PA) biosynthesis in plants are not fully understood. Here Medicago truncatula bHLH MtTT8 was characterized as a central component of these ternary complexes that control anthocyanin and PA biosynthesis. Mttt8 mutant seeds have a transparent testa phenotype with reduced PAs and anthocyanins. MtTT8 restores PA and anthocyanin productions in Arabidopsis tt8 mutant. Ectopic expression of MtTT8 restores anthocyanins and PAs in mttt8 plant and hairy roots and further enhances both productions in wild-type hairy roots. Transcriptomic analyses and metabolite profiling of mttt8 mutant seeds and M. truncatula hairy roots (mttt8 mutant, mttt8 mutant complemented with MtTT8, or MtTT8 overexpression lines) indicate that MtTT8 regulates a subset of genes involved in PA and anthocyanin biosynthesis. MtTT8 is genetically regulated by MtLAP1, MtPAR and MtWD40-1. Combinations of MtPAR, MtLAP1, MtTT8 and MtWD40-1 activate MtTT8 promoter in yeast assay. MtTT8 interacts with these transcription factors to form regulatory complexes. MtTT8, MtWD40-1 and an MYB factor, MtPAR or MtLAP1, interacted and activated promoters of anthocyanidin reductase and anthocyanidin synthase to regulate PA and anthocyanin biosynthesis, respectively. Our results provide new insights into the complex regulation of PA and anthocyanin biosynthesis in M. truncatula. © 2016 The Authors. New Phytologist © 2016 New Phytologist Trust.

  10. Quadrivalent meningococcal (MenACWY-TT) conjugate vaccine or a fourth dose of H. influenzae-N. meningitidis C/Y conjugate vaccine (HibMenCY-TT) is immunogenic in toddlers who previously received three doses of HibMenCY-TT in infancy.

    Science.gov (United States)

    Leonardi, Michael; Latiolais, Thomas; Sarpong, Kwabena; Simon, Michael; Twiggs, Jerry; Lei, Paul; Rinderknecht, Stephen; Blatter, Mark; Bianco, Veronique; Baine, Yaela; Friedland, Leonard R; Miller, Jacqueline M

    2015-02-11

    Immunogenicity and safety of a single dose of MenACWY-TT or a fourth dose of HibMenCY-TT were evaluated in the second year of life in HibMenCY-TT-primed toddlers. Healthy infants were randomized (5:1) and primed at 2, 4 and 6 months of age with HibMenCY-TT and diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus (DTaP-HBV-IPV) vaccine; or Hib-TT and DTaP-HBV-IPV (control). Recipients of HibMenCY-TT+DTaP-HBV-IPV were re-randomized (2:2:1) to receive MenACWY-TT at 12-15 months and DTaP at 15-18 months; MenACWY-TT co-administered with DTaP at 15-18 months; or HibMenCY-TT at 12-15 months and DTaP at 15-18 months. Controls received DTaP only at 15-18 months due to Hib conjugate vaccine shortage. Serum bactericidal activity using human complement (hSBA) and safety were assessed one month after meningococcal vaccination. After vaccination with MenACWY-TT at 12-15 months or MenACWY-TT+DTaP at 15-18 months, all subjects previously primed for serogroups C/Y had hSBA ≥1:8 for these serogroups. At least 96.1% also had hSBA ≥1:8 for serogroups A/W. All subjects in the HibMenCY-TT group had hSBA ≥1:8 for serogroups C/Y. All pre-defined statistical criteria for meningococcal immunogenicity were satisfied. All vaccination regimens had acceptable safety profiles. Children primed with three doses of HibMenCY-TT who then received a single dose of MenACWY-TT or a fourth dose of HibMenCY-TT had robust increases in hSBA titers for serogroups C/Y. These data provide support that MenACWY-TT, given with or without the fourth scheduled dose of DTaP could be administered as an alternative to a fourth dose of HibMenCY-TT in the second year of life. This study (110870/110871) is registered at www.clinicaltrials.gov NCT00614614. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  11. Effects of intermittent training on anaerobic performance and MCT transporters in athletes.

    Directory of Open Access Journals (Sweden)

    Grégoire Millet

    Full Text Available This study examined the effects of intermittent hypoxic training (IHT on skeletal muscle monocarboxylate lactate transporter (MCT expression and anaerobic performance in trained athletes. Cyclists were assigned to two interventions, either normoxic (N; n = 8; 150 mmHg PIO2 or hypoxic (H; n = 10; ∼3000 m, 100 mmHg PIO2 over a three week training (5×1 h-1h30 x week(-1 period. Prior to and after training, an incremental exercise test to exhaustion (EXT was performed in normoxia together with a 2 min time trial (TT. Biopsy samples from the vastus lateralis were analyzed for MCT1 and MCT4 using immuno-blotting techniques. The peak power output (PPO increased (p<0.05 after training (7.2% and 6.6% for N and H, respectively, but VO2max showed no significant change. The average power output in the TT improved significantly (7.3% and 6.4% for N and H, respectively. No differences were found in MCT1 and MCT4 protein content, before and after the training in either the N or H group. These results indicate there are no additional benefits of IHT when compared to similar normoxic training. Hence, the addition of the hypoxic stimulus on anaerobic performance or MCT expression after a three-week training period is ineffective.

  12. The effect of acute dark chocolate consumption on carbohydrate metabolism and performance during rest and exercise.

    Science.gov (United States)

    Stellingwerff, Trent; Godin, Jean-Philippe; Chou, Chieh J; Grathwohl, Dominik; Ross, Alastair B; Cooper, Karen A; Williamson, Gary; Actis-Goretta, Lucas

    2014-02-01

    Consumption of cocoa-enriched dark chocolate (DC) has been shown to alter glucose and insulin concentration during rest and exercise compared with cocoa-depleted control (CON). However, the impact of DC consumption on exercise metabolism and performance is uncertain. Therefore, we investigated carbohydrate metabolism via stable isotope tracer techniques during exercise after subjects ingested either DC or CON. Sixteen overnight-fasted male cyclists performed a single-blinded, randomized, crossover design trial, after consuming either DC or CON at 2 h prior to 2.5 h of steady-state (SS) exercise (∼45% peak oxygen uptake). This was followed by an ∼15-min time-trial (TT) and 60 min of recovery. [6,6-(2)H2]Glucose and [U-(13)C]glucose were infused during SS to assess glucose rate of appearance (Ra) and disappearance (Rd). After DC consumption, plasma (-)-glucose and insulin concentrations were significantly (p consumption coincided with high concentrations of epicatechin and (or) theobromine. In summary, DC consumption altered muscle carbohydrate partitioning, between muscle glucose uptake and glycogen oxidation, but did not effect cycling TT performance.

  13. Nighttime feeding likely alters morning metabolism but not exercise performance in female athletes.

    Science.gov (United States)

    Ormsbee, Michael J; Gorman, Katherine A; Miller, Elizabeth A; Baur, Daniel A; Eckel, Lisa A; Contreras, Robert J; Panton, Lynn B; Spicer, Maria T

    2016-07-01

    The timing of morning endurance competition may limit proper pre-race fueling and resulting performance. A nighttime, pre-sleep nutritional strategy could be an alternative method to target the metabolic and hydrating needs of the early morning athlete without compromising sleep or gastrointestinal comfort during exercise. Therefore, the purpose of this investigation was to examine the acute effects of pre-sleep chocolate milk (CM) ingestion on next-morning running performance, metabolism, and hydration status. Twelve competitive female runners and triathletes (age, 30 ± 7 years; peak oxygen consumption, 53 ± 4 mL·kg(-1)·min(-1)) randomly ingested either pre-sleep CM or non-nutritive placebo (PL) ∼30 min before sleep and 7-9 h before a morning exercise trial. Resting metabolic rate (RMR) was assessed prior to exercise. The exercise trial included a warm-up, three 5-min incremental workloads at 55%, 65%, and 75% peak oxygen consumption, and a 10-km treadmill time trial (TT). Physiological responses were assessed prior, during (incremental and TT), and postexercise. Paired t tests and magnitude-based inferences were used to determine treatment differences. TT performances were not different ("most likely trivial" improvement with CM) between conditions (PL: 52.8 ± 8.4 min vs CM: 52.8 ± 8.0 min). RMR was "likely" increased (4.8%) and total carbohydrate oxidation (g·min(-1)) during exercise was "possibly" or likely increased (18.8%, 10.1%, 9.1% for stage 1-3, respectively) with CM versus PL. There were no consistent changes to hydration indices. In conclusion, pre-sleep CM may alter next-morning resting and exercise metabolism to favor carbohydrate oxidation, but effects did not translate to 10-km running performance improvements.

  14. ttH, H → WW(*) analysis at Atlas, LHC and Very Low Energy electron studies of 2004 combined test beam

    International Nuclear Information System (INIS)

    Zhang, H.

    2008-06-01

    The Large Hadron Collider(LHC) at CERN is a proton-proton collider with a designed center of mass energy of 14 TeV. ATLAS is a general purpose particle detector located at one of the colliding point of the LHC. Using ATLAS Computing System Commissioning (CSC) Monte Carlo full simulation data of the tt-bar H, H → WW * channel, this thesis studies the feasibility of measuring top-quark Yukawa Coupling up to 30 fb -1 integrated luminosity, within the intermediate Higgs mass range from 120 to 200 GeV. For the first time, trigger, pileup effects as well as all possible systematic uncertainties are extensively studied. For a Higgs mass of 160 GeV, with the detailed systematics uncertainties studied, the signal significance is shown to exceed 2σ by combining 2 leptons and 3 leptons final states together. The combined branching ratio of σ tt -bar H *BR H→WW (*) can reach an accuracy of 47%, and gives important information on the top quark Yukawa Coupling. This is the first study of the tt-bar H, H → WW * channel based on full simulation data, including a complete and detailed study of the systematic uncertainties. The most difficult part of the tt-bar H, H → WW * analysis is to extract signal from an abundant background since the total cross section of signal is only 0.1% of the main background. Moreover, signals have a complex final state of at least 4 jets, 2 leptons, 2 neutrinos, making the Higgs mass reconstruction very difficult. Lepton isolation is one of the most powerful method to suppress reducible backgrounds. This thesis develops a special Cone Isolation procedure, which suppress by a factor 5 the main tt-bar background. Lepton energy scale uncertainty is one of the important systematics for the tt-bar H, H → WW * analysis. A good linearity of Very Low Energy (VLE) electrons can improve the performance of estimating electron energy scale. The second part of this thesis presents a study of the linearity of VLE electron from 2004 ATLAS Combined Test

  15. THE EFFECT OF TAPERING PERIOD ON PLASMA PRO-INFLAMMATORY CYTOKINE LEVELS AND PERFORMANCE IN ELITE MALE CYCLISTS

    Directory of Open Access Journals (Sweden)

    Peter M. Tiidus

    2009-12-01

    Full Text Available The aim of this study was to investigate the effect of two different tapering period lengths on the concentration of plasma interleukin- 6 (IL-6, interleukin (IL-1β and tumor necrosis factor-? (TNF-α and performance in elite male cyclists. To this end, after completing 8 weeks progressive endurance exercise, twenty four high-level endurance cyclists were randomly assigned to one of two groups: a control group of cyclists (n = 12 continued performing progressive weekly training volume for 3 weeks while a taper group of cyclists (n = 12 proceeded with a 50% reduction in weekly training volume relative to the control group. A simulated 40 min time trial (40TT performance ride was used as the criterion index of performance before and after the tapering period to evaluate the physiological and performance effects of each protocol. Blood samples were collected immediately post-40TT from all participants at the beginning of week 1, and the end of weeks 4, 8, 9 and 11. IL-1β, IL-6 and TNFα were assayed using a standard commercial ELISA kits (Quantikine; R & D Systems, Minneapolis, MN. The mean time to complete the 40TT in the taper group decreased significantly (p < 0.01 after both 1 and 3 weeks with reduced training volume relative to the control group. There were significant reductions in (p < 0.001 IL-1β, IL-6 and TNFα concentrations in the taper group relative to the control group at the end of the 3 week tapering period, but not at the end of the 1 week tapering period. These results demonstrate that both a 1 and a 3 week taper period will result in improved physical performance in trained cyclists but only a 3 week taper period will result in attenuation of post-exercise pro- inflammatory cytokines when compared to those continuing a more intense training regimen

  16. Abnormal differentiation, hyperplasia and embryonic/perinatal lethality in BK5-T/t transgenic mice

    Science.gov (United States)

    Chen, Xin; Schneider-Broussard, Robin; Hollowell, Debra; McArthur, Mark; Jeter, Collene R.; Benavides, Fernando; DiGiovanni, John; Tang, Dean G.

    2009-01-01

    The cell-of-origin has a great impact on the types of tumors that develop and the stem/progenitor cells have long been considered main targets of malignant transformation. The SV40 large T and small t antigens (T/t), have been targeted to multiple differentiated cellular compartments in transgenic mice. In most of these studies, transgenic animals develop tumors without apparent defects in animal development. In this study, we used the bovine keratin 5 (BK5) promoter to target the T/t antigens to stem/progenitor cell-containing cytokeratin 5 (CK5) cellular compartment. A transgene construct, BK5-T/t, was made and microinjected into the male pronucleus of FVB/N mouse oocytes. After implanting ∼1700 embryos, only 7 transgenics were obtained, including 4 embryos (E9.5, E13, E15, and E20) and 3 postnatal animals, which died at P1, P2, and P18, respectively. Immunohistological analysis revealed aberrant differentiation and prominent hyperplasia in several transgenic CK5 tissues, especially the upper digestive organs (tongue, oral mucosa, esophagus, and forestomach) and epidermis, the latter of which also showed focal dysplasia. Altogether, these results indicate that constitutive expression of the T/t antigens in CK5 cellular compartment results in abnormal epithelial differentiation and leads to embryonic/perinatal animal lethality. PMID:19272531

  17. ttH Coupling Measurement with the ATLAS Detector at the LHC

    CERN Document Server

    Hadef, Asma; The ATLAS collaboration

    2017-01-01

    The Higgs boson is discovered on the 4th of July 2012 with a mass around 125 $\\text{GeV}/c^2$ by ATLAS and CMS experiments at LHC. Determining the Higgs properties (production and decay modes, couplings,...) is an important part of the high-energy physics programme in this decade. A search for the Higgs boson production in association with a top quark pair (ttH) at ATLAS is presented in this talk at an unexplored center-of-mass energy of 13 TeV, which could allow a first direct measurement of the top quark Yukawa coupling and could reveal new physics. The ttH analysis in ATLAS is divided into 3 channels according to the Higgs decay modes: $H \\rightarrow$ Hadrons, $H \\rightarrow$ Leptons and $H \\rightarrow$ Photons. The best-fit value of the ratio of observed and Standard Model cross sections of ttH production process, using 2015-2016 data and combining all ttH final states, is 1.8 $\\pm$ 0.7, corresponds to 2.8 $\\sigma$ (1.8 $\\sigma$) observed (expected) significance.

  18. Tobacco randomly inserted tt8 differenly enhance light signals and flavonoid accumulation

    International Nuclear Information System (INIS)

    Sompornpailin, K.; Kanthang, S.

    2015-01-01

    The individual lines of tobacco over-expressing TT8, a bHLH gene, were constructed and cultured under tissue culture condition radiating with photosynthetically activation radiation (PAR) or PAR+UVA. They were compared to wild type (WT). Leaf of treated plants was extracted and analyzed for flavonoid accumulations using a spectrophotometer. The extract of TT8 plants significantly contained flavone, flavonol and anthocyanin level, higher than the WT extract did. The petal extracts of mature transgenic under PAR had a similar absorbance profile of each substance, but these extracts had higher flavonoid contents than the leaf extracts did. All flavonoid subgroups and p-coumaric acid biosynthesis were significantly enhanced after the additional UVA radiation to plant. This UVA condition slightly stimulated an accumulation of these substances in normal plant. Some transgenic greatly increased flavonoid accumulation in responding to PAR+UVA, but the others were slightly different compared to WT. The distinct insertion site is directly affected TT8 gene expression. Transgenic seeds had a dark brown color more than WT seed, which indicated high content of polymer flavonoids (proanthocyanins). This over-expressing TT8 in transgenic tobacco may directly or indirectly enhance the signal transductions of PAR and UVA and raise up flavonoid accumulation. (author)

  19. 31 CFR 203.4 - Financial institution eligibility for designation as a TT&L depositary.

    Science.gov (United States)

    2010-07-01

    ... PAYMENT OF FEDERAL TAXES AND THE TREASURY TAX AND LOAN PROGRAM General Information § 203.4 Financial... secure TT&L account balances, a TIP main account balance, an SDI account balance, or a no account balance... Federal tax deposits through PATAX, a financial institution must possess under its charter either general...

  20. Küsimus ja vastus / Kalmer Hütt, Mercedes Merimaa, Igor Jallai, Toomas Takkis

    Index Scriptorium Estoniae

    2007-01-01

    Kandideerite riigikokku. Miks? Vastavad: Kalmer Hütt (Häädemeeste Keskkooli matemaatikaõpetaja), Mercedes Merimaa (Audru Keskkooli arvuti- ja bioloogiaõpetaja), Igor Jallai (Valga Vene Gümnaasiumi arvutiõpetaja), Toomas Takkis (Kuressaare Gümnaasiumi direktor)

  1. Tensor-Train Split-Operator Fourier Transform (TT-SOFT) Method: Multidimensional Nonadiabatic Quantum Dynamics.

    Science.gov (United States)

    Greene, Samuel M; Batista, Victor S

    2017-09-12

    We introduce the "tensor-train split-operator Fourier transform" (TT-SOFT) method for simulations of multidimensional nonadiabatic quantum dynamics. TT-SOFT is essentially the grid-based SOFT method implemented in dynamically adaptive tensor-train representations. In the same spirit of all matrix product states, the tensor-train format enables the representation, propagation, and computation of observables of multidimensional wave functions in terms of the grid-based wavepacket tensor components, bypassing the need of actually computing the wave function in its full-rank tensor product grid space. We demonstrate the accuracy and efficiency of the TT-SOFT method as applied to propagation of 24-dimensional wave packets, describing the S 1 /S 2 interconversion dynamics of pyrazine after UV photoexcitation to the S 2 state. Our results show that the TT-SOFT method is a powerful computational approach for simulations of quantum dynamics of polyatomic systems since it avoids the exponential scaling problem of full-rank grid-based representations.

  2. ttH coupling measurements in ATLAS and combined results of 8 TeV data

    Energy Technology Data Exchange (ETDEWEB)

    Sopczak, Andre; Ali, Babar; Seifert, Frank [IEAP CTU in Prague (Czech Republic); Gentile, Simonetta; Kuna, Marine; Monzani, Simone [La Sapienza Universita, Roma (Italy); INFN, Roma (Italy)

    2016-07-01

    After the discovery of a Higgs boson, the measurements of its properties are now at the forefront of research. The measurement of the associated production of a Higgs boson and a pair of top quarks is of particular importance as the ttH Yukawa coupling is large, and thus a probe for physics beyond the Standard Model. For the first time the ttH production was analysed in the final state with two same-sign light leptions (electrons or muons) and a hadronically decaying tau lepton: ttH → 2l+1 τ{sub had}. The analysis was based on data taken by the ATLAS experiment recorded from 8 TeV proton-proton collisions. It contributed significantly to the combined ATLAS results of the five multi-lepton final states. These results were further combined with other ATLAS ttH analyses where H → γγ and H → b anti b. The combined results are consistent with the Standard Model (SM) expectation allowing models beyond the SM to be constrained.

  3. Time of Day and Training Status Both Impact the Efficacy of Caffeine for Short Duration Cycling Performance

    Directory of Open Access Journals (Sweden)

    James C. Boyett

    2016-10-01

    Full Text Available This project was designed to assess the effects of time of day and training status on the benefits of caffeine supplementation for cycling performance. Twenty male subjects (Age, 25 years; Peak oxygen consumption, 57 mL·kg−1·min−1 were divided into tertiles based on training levels, with top and bottom tertiles designated as ‘trained’ (n = 7 and ‘untrained’ (n = 7. Subjects completed two familiarization trials and four experimental trials consisting of a computer-simulated 3-km cycling time trial (TT. The trials were performed in randomized order for each combination of time of day (morning and evening and treatment (6mg/kg of caffeine or placebo. Magnitude-based inferences were used to evaluate all treatment effects. For all subjects, caffeine enhanced TT performance in the morning (2.3% ± 1.7%, ‘very likely’ and evening (1.4% ± 1.1%, ‘likely’. Both untrained and trained subjects improved performance with caffeine supplementation in the morning (5.5% ± 4.3%, ‘likely’; 1.0% ± 1.7%, ‘likely’, respectively, but only untrained subjects rode faster in the evening (2.9% ± 2.6%, ‘likely’. Altogether, our observations indicate that trained athletes are more likely to derive ergogenic effects from caffeine in the morning than the evening. Further, untrained individuals appear to receive larger gains from caffeine in the evening than their trained counterparts.

  4. Time of Day and Training Status Both Impact the Efficacy of Caffeine for Short Duration Cycling Performance.

    Science.gov (United States)

    Boyett, James C; Giersch, Gabrielle E W; Womack, Christopher J; Saunders, Michael J; Hughey, Christine A; Daley, Hannah M; Luden, Nicholas D

    2016-10-14

    This project was designed to assess the effects of time of day and training status on the benefits of caffeine supplementation for cycling performance. Twenty male subjects (Age, 25 years; Peak oxygen consumption, 57 mL·kg -1 ·min -1 ) were divided into tertiles based on training levels, with top and bottom tertiles designated as 'trained' ( n = 7) and 'untrained' ( n = 7). Subjects completed two familiarization trials and four experimental trials consisting of a computer-simulated 3-km cycling time trial (TT). The trials were performed in randomized order for each combination of time of day (morning and evening) and treatment (6mg/kg of caffeine or placebo). Magnitude-based inferences were used to evaluate all treatment effects. For all subjects, caffeine enhanced TT performance in the morning (2.3% ± 1.7%, 'very likely') and evening (1.4% ± 1.1%, 'likely'). Both untrained and trained subjects improved performance with caffeine supplementation in the morning (5.5% ± 4.3%, 'likely'; 1.0% ± 1.7%, 'likely', respectively), but only untrained subjects rode faster in the evening (2.9% ± 2.6%, 'likely'). Altogether, our observations indicate that trained athletes are more likely to derive ergogenic effects from caffeine in the morning than the evening. Further, untrained individuals appear to receive larger gains from caffeine in the evening than their trained counterparts.

  5. Searches for High-Mass $tt^-$ Resonances at CMS

    CERN Document Server

    Mc Lean, Christine Angela

    2016-01-01

    We present a search for new massive particles decaying to a pair of top quarks with the CMS detector at the LHC. Proton-proton collision data recorded at a centre-of-mass energy of 13 TeV are used. The search is performed by measuring the invariant mass distribution of the top-quark pair and testing for deviations from the expected Standard Model background. Final states with 0 or 1 leptons are considered and the selection optimised accordingly. In the high mass ranges accessible by the LHC at these energies the top quarks are produced with high transverse momentum the products of hadronically decaying top quarks emerge as a single jet, whereas the products of the semileptonic decay mode are characterised by the overlap of the lepton to the b jet. Specific reconstruction algorithm and selections are employed to address the identification of boosted top quark signatures. The results are presented in terms of upper limits on the model cross section. Models of Randall-Sundrum Kaluza-Klein gluon production as wel...

  6. Aspectos patológicos, imunológicos e propriedades moleculares do TT vírus Pathological and immunological aspects and molecular properties of TT virus

    Directory of Open Access Journals (Sweden)

    Maria Angelica Ehara Watanabe

    2005-08-01

    Full Text Available O TT vírus (TTV foi primeiramente descrito no Japão, em 1997, por T. Nishizawa, no soro de pacientes com hepatite, pós-transfusão, não-A-G. Tem sido intensivamente investigado, desde então, como uma possível adição à lista dos vírus indutores de hepatite. O TTV é um vírus DNA não-envelopado, de fita simples. Uma considerável variabilidade genética tem sido demonstrada por parte do TTV, o que tem levado pesquisadores a agrupar isolados do vírus em inúmeros genótipos e subtipos. No entanto a significância clínica da infecção por TTV permanece desconhecida. Ele é freqüentemente detectado em fluidos corporais e seu componente mais bem elucidado atualmente é o genoma. Conhecimentos relacionados ao TTV têm aumentado constantemente, porém vários aspectos fundamentais permanecem obscuros. Esta revisão apresenta algumas das propriedades moleculares do TT vírus.TT virus (TTV was first reported in Japan in 1997 by T. Nishizawa in sera from non-A to non-G post-transfusion hepatitis patients. It has been intensively investigated, ever since, as a possible addition to the list of hepatitis-inducing viruses. The TTV is an unenveloped, single-stranded DNA virus. Considerable genetic variability of TTV has been demonstrated and has led investigators to group its isolates into numerous genotypes and subtypes. However, the clinical significance of TTV infection remains unknown. It is frequently detected in the serum and in other body fluids of humans. The component of TTV currently best understood is its genome. Knowledge related to TTV has increased rapidly, but many fundamental aspects remain unclear. This review shows some of the molecular properties of TT virus.

  7. Energy deposition in liquid metals for D-T, D-D and T-T fusion sources

    International Nuclear Information System (INIS)

    Ragheb, M.M.H.; Zahakaylo, D.

    1983-01-01

    The nuclear performance of candidate liquid metals: lithium, lead, sodium, potassiu, Na(22%) K(78%), Na(56%) K(44%), is estimated with respect to their neutron and gamma-ray heat deposition rates. Three different neutron sources are considered: DT, DD and TT fusion neutrons. This is intended for the cooling of inertial confinement cavities using fusion pellets with internal tritrium breeding that will possibly eliminate the need to breed tritium in a lithium blanket. Compared to lithium with respect to neutron and gamma energy generation, blanket multiplication and pumping power, it appears that the considered metals can be used only if the environmental and safety advantages from the reduction of the tritium inventory and the avoidance of lithium, outweight the lithium advantages in higher energy production and lower pumping requirement by one to two orders of magnitude. (orig.) [de

  8. The preproghrelin 3056 TT genotype is associated with the feeling of hunger and low acylated ghrelin levels in Japanese patients with Helicobacter pylori-negative functional dyspepsia.

    Science.gov (United States)

    Futagami, Seiji; Shimpuku, Mayumi; Kawagoe, Tetsuro; Izumi, Nikki; Ohishi, Noriko; Yamawaki, Hiroshi; Shindo, Tomotaka; Nagoya, Hiroyuki; Horie, Akane; Kodaka, Yasuhiro; Gudis, Katya; Itoh, Takashi; Sakamoto, Choitsu

    2013-01-01

    An impairment of gastric motility is strongly associated with the pathophysiology of functional dyspepsia (FD). Plasma ghrelin is one of the key molecules linked to gastric motility. Therefore, this study aimed to evaluate whether ghrelin (GHRL) gene polymorphisms are associated with clinical symptoms, the plasma ghrelin levels and gastric emptying in patients with FD as defined by the Rome III classification. We enrolled 74 Helicobacter pylori-negative patients presenting with typical symptoms of FD (epigastric pain syndrome (EPS), n=23; postprandial distress syndrome (PDS), n=51) and 102 healthy volunteers. Gastric motility was evaluated according to the Tmax value and T1/2 using the (13)C-acetate breath test. We used the Rome III criteria to evaluate upper abdominal symptoms and SRQ-D scores to determine the depression status. The Arg51Gln(346G->A), preproghrelin3056T->C, Leu72Met(408C->A) and Gln90Leu(3412T->A) polymorphisms were analyzed in DNA in blood samples obtained from the enrolled subjects. Genotyping was performed using polymerase chain reaction. There was a significant relationship (p=0.048) between the preproghrelin 3056TT genotype and the serum levels of acylated ghrelin in the H. pylori-negative FD patients. The preproghrelin 3056TT genotype was significantly (p=0.047) associated with the feeling of hunger in the H. pylori-negative FD patients. The preproghrelin 3056TT genotype is significantly associated with the acylated ghrelin levels and the feeling of hunger in H. pylori-negative FD patients. Further studies are needed to clarify the association between the preproghrelin 3056TT genotype and lower plasma acylated ghrelin levels and the impact of this relationship on the feeling of hunger in H. pylori-negative FD patients.

  9. Boosted Decision Tree Optimization for the ATLAS search of ttH production in the 2l same-sign channel

    CERN Document Server

    Rojas Huamani, Jairo Martin

    2017-01-01

    The main goal is to have a direct measurement of the Yukawa coupling of the Higgs boson to the top quark which is only possible in the production process → ttH + . In this analysis, final states with 2 same sign leptons (neutrinos not counted) have been used in order to estimate the expected significance of the ttH process. A study using Boosted Decision Trees was done using Monte Carlo simulation equivalent to a luminosity of 36.5 fb-1 at √s=13 TeV, characteristics of the years 2015 and 2016 of Run-2 at LHC. The focus of my summer student program was to investigate the performance of the BDT, mainly: To avoid building of a rigid and possible overtrained BTD (Boosted Decision Tree) in charge of identifying pp→ttH+X process by removing systematically the number of variables used in the analysis. Look the expected sensitivity’s dependence on different parameters that takes in account the BDT.

  10. Aerodynamics of a cycling team in a time trial: does the cyclist at the front benefit?

    International Nuclear Information System (INIS)

    Iniguez-de-la Torre, A; Iniguez, J

    2009-01-01

    When seasonal journeys take place in nature, birds and fishes migrate in groups. This provides them not only with security but also a considerable saving of energy. The power they need to travel requires overcoming aerodynamic or hydrodynamic drag forces, which can be substantially reduced when the group travels in an optimal arrangement. Also in this area, humans imitate nature, which is especially evident in the practice of outdoor sports and motor competitions. Cycle races, in which speeds of up to 15 m s -1 are frequent, offer great opportunities to appreciate the advantage of travelling in a group. Here we present a brief analysis of the aerodynamics of a cycling team in a time-trial challenge, showing how each rider is favoured according to his position in the group. We conclude that the artificial tail wind created by the team also benefits the cyclist at the front by about 5%.

  11. Aerodynamics of a cycling team in a time trial: does the cyclist at the front benefit?

    Science.gov (United States)

    Íñiguez-de-la Torre, A.; Íñiguez, J.

    2009-11-01

    When seasonal journeys take place in nature, birds and fishes migrate in groups. This provides them not only with security but also a considerable saving of energy. The power they need to travel requires overcoming aerodynamic or hydrodynamic drag forces, which can be substantially reduced when the group travels in an optimal arrangement. Also in this area, humans imitate nature, which is especially evident in the practice of outdoor sports and motor competitions. Cycle races, in which speeds of up to 15 m s-1 are frequent, offer great opportunities to appreciate the advantage of travelling in a group. Here we present a brief analysis of the aerodynamics of a cycling team in a time-trial challenge, showing how each rider is favoured according to his position in the group. We conclude that the artificial tail wind created by the team also benefits the cyclist at the front by about 5%.

  12. Calibration of the b-tagging algorithms of the jets issued from b quarks and measurement of the differential cross-section for the production of tt-bar pairs in relation to the mass and rapidity of the tt-bar system in p-p collisions at √(s) = 7 TeV in the ATLAS experiment at LHC

    International Nuclear Information System (INIS)

    Tannoury, N.

    2012-01-01

    During the first part of my thesis, I worked on commissioning and developing the System8 method, a data driven method which is used to calibrate the b-tagging algorithms with data. The b-tagging efficiency is a key ingredient to all physics analysis that involve b-jet signature, hence its importance. System8 consists of a non-linear system of 8 equations, where no general analytic solution is known. The system is solved using a minimization of a χ2 using MINUIT. The correlation factors for b and c jets are determined from simulation while the ones for the light-jets are determined from data. The full covariance matrix of the correlation factors is computed and used in the fit to allow a proper propagation of the statistical errors on these correlation factors. During the second half of my thesis, I had the opportunity to analyze a larger sample of data, almost 5 fb -1 , to perform the measurement of the tt-bar differential cross section as function of the tt-bar mass and the tt-bar rapidity. I carried out this measurement by selecting tt-bar event candidates with exactly one lepton, electron or muon, at least four jets with high energy and a large missing transverse energy. This selection gave me the opportunity to familiarize with the different reconstructed physics objects using the ATLAS detector. I estimated the different backgrounds using the standard recommendation of the ATLAS experiment and also reconstructed the tt-bar system using the KLFitter algorithm, which is widely used within the ATLAS collaboration. I applied the unfolding using the inverted matrix method and performed closure tests on simulations which ended with a very good agreement with the Monte Carlo truth. The measurement on data was done with the full estimation of the different systematic uncertainties. The results agree with NLO predictions and approximately NNLO predictions. No significant deviation from the SM expectations are observed. No resonance nor a distortion in the tt

  13. Corrosion fatigue cracking behavior of Inconel 690 (TT) in secondary water of pressurized water reactors

    International Nuclear Information System (INIS)

    Xiao Jun; Chen Luyao; Qiu Shaoyu; Chen Yong; Lin Zhenxia; Fu Zhenghong

    2015-01-01

    Inconel 690 (TT) is one of the key materials for tubes of steam generators for pressurized water reactors, where it is susceptible to corrosion fatigue cracking. In this paper, the corrosion fatigue cracking behavior of Inconel 690 (TT) was investigated under small scale yielding conditions, in the simulated secondary water of pressurized water reactor. It was observed that the fatigue crack growth rate was accelerated by a maximum factor up to 3 in the simulated secondary water, comparing to that in room temperature air. In addition, it was found that the accelerating effect was influenced by out-of-plane cracking of corrosion fatigue cracks and also correlated with stress intensity factor range, maximum stress intensity factor and stress ratio. (authors)

  14. Simulating Porous Magnetite Layer Deposited on Alloy 690TT Steam Generator Tubes.

    Science.gov (United States)

    Jeon, Soon-Hyeok; Son, Yeong-Ho; Choi, Won-Ik; Song, Geun Dong; Hur, Do Haeng

    2018-01-02

    In nuclear power plants, the main corrosion product that is deposited on the outside of steam generator tubes is porous magnetite. The objective of this study was to simulate porous magnetite that is deposited on thermally treated (TT) Alloy 690 steam generator tubes. A magnetite layer was electrodeposited on an Alloy 690TT substrate in an Fe(III)-triethanolamine solution. After electrodeposition, the dense magnetite layer was immersed to simulate porous magnetite deposits in alkaline solution for 50 days at room temperature. The dense morphology of the magnetite layer was changed to a porous structure by reductive dissolution reaction. The simulated porous magnetite layer was compared with flakes of steam generator tubes, which were collected from the secondary water system of a real nuclear power plant during sludge lancing. Possible nuclear research applications using simulated porous magnetite specimens are also proposed.

  15. Safety and immunogenicity of a CRM or TT conjugated meningococcal vaccine in healthy toddlers.

    Science.gov (United States)

    Bona, Gianni; Castiglia, Paolo; Zoppi, Giorgio; de Martino, Maurizio; Tasciotti, Annaelisa; D'Agostino, Diego; Han, Linda; Smolenov, Igor

    2016-06-17

    MenACWY-CRM (Menveo(®); GlaxoSmithKline) and MenACWY-TT (Nimenrix(®); Pfizer) are two meningococcal vaccines licensed in the European Union for use in both children and adults. While both vaccines target meningococcal serogroups A, C, W and Y, immunogenicity and reactogenicity of these quadrivalent meningococcal conjugate vaccines may differ due to differences in formulation processes and chemical structure. Yet data on the comparability of these two vaccines are limited. The reactogenicity and immunogenicity of one dose of either MenACWY-CRM or MenACWY-TT were evaluated in healthy toddlers aged 12-15 months. Immunogenicity was assessed using serum bactericidal antibody assays (SBA) with human (hSBA) and rabbit (rSBA) complement. A total of 202 children aged 12-15 months were enrolled to receive one dose of MenACWY-CRM or MenACWY-TT. Similar numbers of subjects reported solicited reactions within 7 days following either vaccination. Tenderness at the injection site was the most common local reaction. Systemic reactions reported were similar for both vaccines and mostly mild to moderate in severity: irritability, sleepiness and change in eating habits were most commonly reported. Immunogenicity at 1 month post-vaccination was generally comparable for both vaccines across serogroups. At 6 months post-vaccination antibody persistence against serogroups C, W, and Y was substantial for both vaccines, as measured by both assay methodologies. For serogroup A, hSBA titers declined in both groups, while rSBA titers remained high. Despite differences in composition, the MenACWY-CRM and MenACWY-TT vaccines have comparable reactogenicity and immunogenicity profiles. Immediate immune responses and short-term antibody persistence were largely similar between groups. Both vaccines were well-tolerated and no safety concerns were identified. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  16. Novel Atlantic bottlenose dolphin parainfluenza virus TtPIV-1 clusters with bovine PIV-3 genotype B strains.

    Science.gov (United States)

    Eberle, Kirsten C; Neill, John D; Venn-Watson, Stephanie K; McGill, Jodi L; Sacco, Randy E

    2015-10-01

    Parainfluenza virus 3 (PIV-3) is a common viral infection not only in humans, but also in many other species. Serological evidence suggests that nearly 100 % of children in the United States have been infected with PIV-3 by 5 years of age. Similarly, in cattle, PIV-3 is commonly associated with bovine respiratory disease complex. A novel dolphin PIV-3 (TtPIV-1) was described by Nollens et al. in 2008 from a dolphin that was diagnosed with an unknown respiratory illness. At that time, TtPIV-1 was found to be most similar to, but distinct from, bovine PIV-3 (BPIV-3). In the present study, similar viral growth kinetics and pro-inflammatory cytokine (IL-1β, IL-6, and CXCL8) production were seen between BPIV-3 and TtPIV-1 in BEAS-2B, MDBK, and Vero cell lines. Initial nomenclature of TtPIV-1 was based on partial sequence of the fusion and RNA polymerase genes. Based on the similarities we saw with the in vitro work, it was important to examine the TtPIV-1 genome in more detail. Full genome sequencing and subsequent phylogenetic analysis revealed that all six viral genes of TtPIV-1 clustered within the recently described BPIV-3 genotype B strains, and it is proposed that TtPIV-1 be re-classified with BPIV-3 genotype B strains.

  17. MTHFR 677TT genotype and disease risk: is there a modulating role for B-vitamins?

    Science.gov (United States)

    Reilly, R; McNulty, H; Pentieva, K; Strain, J J; Ward, M

    2014-02-01

    Methylenetetrahydrofolate reductase (MTHFR) is a critical folate-metabolising enzyme which requires riboflavin as its co-factor. A common polymorphism (677C→T) in the MTHFR gene results in reduced MTHFR activity in vivo which in turn leads to impaired folate metabolism and elevated homocysteine concentrations. Homozygosity for this polymorphism (TT genotype) is associated with an increased risk of a number of conditions including heart disease and stroke, but there is considerable variability in the extent of excess risk in various reports. The present review will explore the evidence which supports a role for this polymorphism as a risk factor for a number of adverse health outcomes, and the potential modulating roles for B-vitamins in alleviating disease risk. The evidence is convincing in the case which links this polymorphism with hypertension and hypertensive disorders of pregnancy, particularly preeclampsia. Furthermore, elevated blood pressure was found to be highly responsive to riboflavin intervention specifically in individuals with the MTHFR 677TT genotype. Future intervention studies targeted at these genetically predisposed individuals are required to further investigate this novel gene-nutrient interaction. This polymorphism has also been associated with an increased risk of neural tube defects (NTD) and other adverse pregnancy outcomes; however, the evidence in this area has been inconsistent. Preliminary evidence has suggested that there may be a much greater need for women with the MTHFR 677TT genotype to adhere to the specific recommendation of commencing folic acid prior to conception for the prevention of NTD, but this requires further investigation.

  18. Selective alkylation of T-T mismatched DNA using vinyldiaminotriazine-acridine conjugate.

    Science.gov (United States)

    Onizuka, Kazumitsu; Usami, Akira; Yamaoki, Yudai; Kobayashi, Tomohito; Hazemi, Madoka E; Chikuni, Tomoko; Sato, Norihiro; Sasaki, Kaname; Katahira, Masato; Nagatsugi, Fumi

    2018-02-16

    The alkylation of the specific higher-order nucleic acid structures is of great significance in order to control its function and gene expression. In this report, we have described the T-T mismatch selective alkylation with a vinyldiaminotriazine (VDAT)-acridine conjugate. The alkylation selectively proceeded at the N3 position of thymidine on the T-T mismatch. Interestingly, the alkylated thymidine induced base flipping of the complementary base in the duplex. In a model experiment for the alkylation of the CTG repeats DNA which causes myotonic dystrophy type 1 (DM1), the observed reaction rate for one alkylation increased in proportion to the number of T-T mismatches. In addition, we showed that primer extension reactions with DNA polymerase and transcription with RNA polymerase were stopped by the alkylation. The alkylation of the repeat DNA will efficiently work for the inhibition of replication and transcription reactions. These functions of the VDAT-acridine conjugate would be useful as a new biochemical tool for the study of CTG repeats and may provide a new strategy for the molecular therapy of DM1.

  19. Evidensgraderingssystemet GRADE : Ett sätt att granska vetenskaplig kunskap om metoder och arbetssätt i hälso- och sjukvården

    OpenAIRE

    Roback, Kerstin; Carlsson, Per

    2009-01-01

    Beslut om införande av nya behandlingsmetoder och arbetssätt i sjukvården präglas alltid av en viss grad av osäkerhet. De studier som gjorts av metodens för- och nackdelar kan vara av olika god kvalitet och därmed ge mer eller mindre säkra resultat. Efter att användningen av systematiska litteraturstudier vid medicinsk teknologiutvärdering tog fart på 1980-talet började man efterfråga ett beslutsunderlag som även tar hänsyn till olika studiers kvalitet. Detta initierade utvecklingen av flera ...

  20. A Radish Basic Helix-Loop-Helix Transcription Factor, RsTT8 Acts a Positive Regulator for Anthocyanin Biosynthesis

    Directory of Open Access Journals (Sweden)

    Sun-Hyung Lim

    2017-11-01

    Full Text Available The MYB-bHLH-WDR (MBW complex activates anthocyanin biosynthesis through the transcriptional regulation. RsMYB1 has been identified as a key player in anthocyanin biosynthesis in red radish (Raphanus sativus L., but its partner bHLH transcription factor (TF remains to be determined. In this study, we isolated a bHLH TF gene from red radish. Phylogenetic analysis indicated that this gene belongs to the TT8 clade of the IIIF subgroup of bHLH TFs, and we thus designated this gene RsTT8. Subcellular localization analysis showed that RsTT8-sGFP was localized to the nuclei of Arabidopsis thaliana protoplasts harboring the RsTT8-sGFP construct. We evaluated anthocyanin biosynthesis and RsTT8 expression levels in three radish varieties (N, C, and D that display different red phenotypes in the leaves, root flesh, and root skins. The root flesh of the C variety and the leaves and skins of the D variety exhibit intense red pigmentation; in these tissues, RsTT8 expression showed totally positive association with the expression of RsMYB1 TF and of five of eight tested anthocyanin biosynthesis genes (i.e., RsCHS, RsCHI, RsF3H, RsDFR, and RsANS. Heterologous co-expression of both RsTT8 and RsMYB1 in tobacco leaves dramatically increased the expression of endogenous anthocyanin biosynthesis genes and anthocyanin accumulation. Furthermore, a yeast two-hybrid assay showed that RsTT8 interacts with RsMYB1 at the MYB-interacting region (MIR, and a transient transactivation assay indicated that RsTT8 activates the RsCHS and RsDFR promoters when co-expressed with RsMYB1. Complementation of the Arabidopsis tt8-1 mutant, which lacks red pigmentation in the leaves and seeds, with RsTT8 restored red pigmentation, and resulted in high anthocyanin and proanthocyanidin contents in the leaves and seeds, respectively. Together, these results show that RsTT8 functions as a regulatory partner with RsMYB1 during anthocyanin biosynthesis.

  1. Charge mis-identification determination in the 2 leptons same sign channel of ttH$\\rightarrow$leptons and combination of all ttH$\\rightarrow$leptons channels with ATLAS

    CERN Document Server

    Chomont, Arthur Rene; The ATLAS collaboration

    2017-01-01

    Description of the charge misidentification estimation in the channels with 2 same-sign lepton in the ttH multilepton channel. The description of the combined fit of the different multilepton channels is also presented as well as results.

  2. Immunotoxicological Evaluation of Genetically Modified Rice Expressing Cry1Ab/Ac Protein (TT51-1) by a 6-Month Feeding Study on Cynomolgus Monkeys

    OpenAIRE

    Tan, Xiaoyan; Zhou, Xiaobing; Tang, Yao; Lv, Jianjun; Zhang, Lin; Sun, Li; Yang, Yanwei; Miao, Yufa; Jiang, Hua; Chen, Gaofeng; Huang, Zhiying; Wang, Xue

    2016-01-01

    The present study was performed to evaluate the food safety of TT51-1, a new type of genetically modified rice that expresses the Cry1Ab/Ac protein (Bt toxin) and is highly resistant to most lepidopteran pests. Sixteen male and 16 female cynomolgus monkeys were randomly divided into four groups: conventional rice (non-genetically modified rice, non-GM rice), positive control, 17.5% genetically modified rice (GM rice) and 70% GM rice. Monkeys in the non-GM rice, positive control, and GM rice g...

  3. The fusion of dt{mu}, tt{mu} and dd{mu} molecules in three-layer arrangement including deuterium degrader and moderator

    Energy Technology Data Exchange (ETDEWEB)

    Gheisari, R. [Physics Department, Persian Gulf University, Bushehr 75169 (Iran)

    2010-09-15

    Muon dynamics and forced chemical confinement fusion in three-layer arrangement consisting of the H/T, D{sub 2} (the degrader and moderator) and D/T fusion layers are investigated with a new kinetic model. Point kinematic equations are numerically solved to calculate the numbers of dt{mu}, tt{mu} and dd{mu} chain reactions. We show that the {mu}-cycling coefficient X{sub c} approximately equals 156, at optimal condition. Our model and results are in contradiction with beliefs of Mahdavi and Zanganeh. Our model is confirmed by recent experiment where was performed for the hydrogen mixture. (author)

  4. Coupling of tt̄ and γγ with a strongly interacting Electroweak Symmetry Breaking Sector

    Directory of Open Access Journals (Sweden)

    Delgado Rafael L.

    2017-01-01

    Full Text Available We report the coupling of an external γγ or tt̄ state to a strongly interacting EWSBS satisfying unitarity. We exploit perturbation theory for those coupling of the external state, whereas the EWSBS is taken as strongly interacting. We use a modified version of the IAM unitarization procedure to model such a strongly interacting regime. The matrix elements VLVL → VLVL, VLVL ↔ hh, hh → hh, VLVL ↔ {γγ, tt̄}, hh ↔ {γγ, tt̄} are all computed to NLO in perturbation theory with the Nonlinear Effective Field Theory of the EWSBS, within the Equivalence Theorem. This allows us to describe resonances of the electroweak sector that may be found at the LHC and their effect on other channels such as γγ or tt̄ where they may be discovered.

  5. NLO QCD corrections to tt-barbb-bar production at the LHC: 1. quark-antiquark annihilation

    International Nuclear Information System (INIS)

    Bredenstein, A.; Denner, A.; Dittmaier, S.; Pozzorini, S.

    2008-01-01

    The process pp → tt-barbb-bar + X represents a very important background reaction to searches at the LHC, in particular to tt-barH production where the Higgs boson decays into a bb-bar pair. A successful analysis of tt-barH at the LHC requires the knowledge of direct tt-barbb-bar production at next-to-leading order in QCD. We take the first step in this direction upon calculating the next-to-leading-order QCD corrections to the subprocess initiated by q q-bar annihilation. We devote an appendix to the general issue of rational terms resulting from ultraviolet or infrared (soft or collinear) singularities within dimensional regularization. There we show that, for arbitrary processes, in the Feynman gauge, rational terms of infrared origin cancel in truncated one-loop diagrams and result only from trivial self-energy corrections.

  6. Evaluation of SAMe-TT2R2 Score on Predicting Success With Extended-Interval Warfarin Monitoring.

    Science.gov (United States)

    Hwang, Andrew Y; Carris, Nicholas W; Dietrich, Eric A; Gums, John G; Smith, Steven M

    2018-06-01

    In patients with stable international normalized ratios, 12-week extended-interval warfarin monitoring can be considered; however, predictors of success with this strategy are unknown. The previously validated SAMe-TT 2 R 2 score (considering sex, age, medical history, treatment, tobacco, and race) predicts anticoagulation control during standard follow-up (every 4 weeks), with lower scores associated with greater time in therapeutic range. To evaluate the ability of the SAMe-TT 2 R 2 score in predicting success with extended-interval warfarin follow-up in patients with previously stable warfarin doses. In this post hoc analysis of a single-arm feasibility study, baseline SAMe-TT 2 R 2 scores were calculated for patients with ≥1 extended-interval follow-up visit. The primary analysis assessed achieved weeks of extended-interval follow-up according to baseline SAMe-TT 2 R 2 scores. A total of 47 patients receiving chronic anticoagulation completed a median of 36 weeks of extended-interval follow-up. The median baseline SAMe-TT 2 R 2 score was 1 (range 0-5). Lower SAMe-TT 2 R 2 scores appeared to be associated with greater duration of extended-interval follow-up achieved, though the differences between scores were not statistically significant. No individual variable of the SAMe-TT 2 R 2 score was associated with achieved weeks of extended-interval follow-up. Analysis of additional patient factors found that longer duration (≥24 weeks) of prior stable treatment was significantly associated with greater weeks of extended-interval follow-up completed ( P = 0.04). Conclusion and Relevance: This pilot study provides limited evidence that the SAMe-TT 2 R 2 score predicts success with extended-interval warfarin follow-up but requires confirmation in a larger study. Further research is also necessary to establish additional predictors of successful extended-interval warfarin follow-up.

  7. Algebraic Structure of tt * Equations for Calabi-Yau Sigma Models

    Science.gov (United States)

    Alim, Murad

    2017-08-01

    The tt * equations define a flat connection on the moduli spaces of {2d, \\mathcal{N}=2} quantum field theories. For conformal theories with c = 3 d, which can be realized as nonlinear sigma models into Calabi-Yau d-folds, this flat connection is equivalent to special geometry for threefolds and to its analogs in other dimensions. We show that the non-holomorphic content of the tt * equations, restricted to the conformal directions, in the cases d = 1, 2, 3 is captured in terms of finitely many generators of special functions, which close under derivatives. The generators are understood as coordinates on a larger moduli space. This space parameterizes a freedom in choosing representatives of the chiral ring while preserving a constant topological metric. Geometrically, the freedom corresponds to a choice of forms on the target space respecting the Hodge filtration and having a constant pairing. Linear combinations of vector fields on that space are identified with the generators of a Lie algebra. This Lie algebra replaces the non-holomorphic derivatives of tt * and provides these with a finer and algebraic meaning. For sigma models into lattice polarized K3 manifolds, the differential ring of special functions on the moduli space is constructed, extending known structures for d = 1 and 3. The generators of the differential rings of special functions are given by quasi-modular forms for d = 1 and their generalizations in d = 2, 3. Some explicit examples are worked out including the case of the mirror of the quartic in {\\mathbbm{P}^3}, where due to further algebraic constraints, the differential ring coincides with quasi modular forms.

  8. Mountain time trial in handcycling : exercise intensity and predictors of race time in people with spinal cord injury

    NARCIS (Netherlands)

    de Groot, Sonja; Postma, Karin; van Vliet, Linda; Timmermans, Remco; Valent, L J M

    Study design: Cross-sectional analyses. Objectives: To analyze exercise intensity during a mountain time trial in handcycling and to determine predictors of race time. Setting: Eight Dutch rehabilitation centers and Austrian mountain. Methods: Forty participants with spinal cord injury (SCI; high

  9. Investigation of tt in the full hadronic final state at CDF with a neural network approach

    CERN Document Server

    Sidoti, A; Busetto, G; Castro, A; Dusini, S; Lazzizzera, I; Wyss, J

    2001-01-01

    In this work we present the results of a neural network (NN) approach to the measurement of the tt production cross-section and top mass in the all-hadronic channel, analyzing data collected at the Collider Detector at Fermilab (CDF) experiment. We have used a hardware implementation of a feedforward neural network, TOTEM, the product of a collaboration of INFN (Istituto Nazionale Fisica Nucleare)-IRST (Istituto per la Ricerca Scientifica e Tecnologica)-University of Trento, Italy. Particular attention has been paid to the evaluation of the systematics specifically related to the NN approach. The results are consistent with those obtained at CDF by conventional data selection techniques. (38 refs).

  10. Search for anomalous kinematics in tt dilepton events at CDF II.

    Science.gov (United States)

    Acosta, D; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arisawa, T; Arguin, J-F; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Bacchetta, N; Bachacou, H; Badgett, W; Barbaro-Galtieri, A; Barker, G J; Barnes, V E; Barnett, B A; Baroiant, S; Barone, M; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Ben-Haim, E; Benjamin, D; Beretvas, A; Bhatti, A; Binkley, M; Bisello, D; Bishai, M; Blair, R E; Blocker, C; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Bolla, G; Bolshov, A; Booth, P S L; Bortoletto, D; Boudreau, J; Bourov, S; Brau, B; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canepa, A; Casarsa, M; Carlsmith, D; Carron, S; Carosi, R; Cavalli-Sforza, M; Castro, A; Catastini, P; Cauz, D; Cerri, A; Cerrito, L; Chapman, J; Chen, C; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Chu, M L; Chuang, S; Chung, J Y; Chung, W-H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Clark, A G; Clark, D; Coca, M; Connolly, A; Convery, M; Conway, J; Cooper, B; Cordelli, M; Cortiana, G; Cranshaw, J; Cuevas, J; Culbertson, R; Currat, C; Cyr, D; Dagenhart, D; Da Ronco, S; D'Auria, S; de Barbaro, P; De Cecco, S; De Lentdecker, G; Dell'Agnello, S; Dell'Orso, M; Demers, S; Demortier, L; Deninno, M; De Pedis, D; Derwent, P F; Dionisi, C; Dittmann, J R; Dörr, C; Doksus, P; Dominguez, A; Donati, S; Donega, M; Donini, J; D'Onofrio, M; Dorigo, T; Drollinger, V; Ebina, K; Eddy, N; Ehlers, J; Ely, R; Erbacher, R; Erdmann, M; Errede, D; Errede, S; Eusebi, R; Fang, H-C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Ferretti, C; Field, R D; Flanagan, G; Flaugher, B; Flores-Castillo, L R; Foland, A; Forrester, S; Foster, G W; Franklin, M; Freeman, J C; Fujii, Y; Furic, I; Gajjar, A; Gallas, A; Galyardt, J; Gallinaro, M; Garcia-Sciveres, M; Garfinkel, A F; Gay, C; Gerberich, H; Gerdes, D W; Gerchtein, E; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Ginsburg, C; Giolo, K; Giordani, M; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, D; Goldstein, J; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Gotra, Y; Goulianos, K; Gresele, A; Griffiths, M; Grosso-Pilcher, C; Grundler, U; Guenther, M; Guimaraes da Costa, J; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B-Y; Handler, R; Happacher, F; Hara, K; Hare, M; Harr, R F; Harris, R M; Hartmann, F; Hatakeyama, K; Hauser, J; Hays, C; Hayward, H; Heider, E; Heinemann, B; Heinrich, J; Hennecke, M; Herndon, M; Hill, C; Hirschhbuehl, D; Hocker, A; Hoffman, K D; Holloway, A; Hou, S; Houlden, M A; Huffman, B T; Huang, Y; Hughes, R E; Huston, J; Ikado, K; Incandela, J; Introzzi, G; Iori, M; Ishizawa, Y; Issever, C; Ivanov, A; Iwata, Y; Iyutin, B; James, E; Jang, D; Jarrell, J; Jeans, D; Jensen, H; Jeon, E J; Jones, M; Joo, K K; Jun, S Y; Junk, T; Kamon, T; Kang, J; Karagoz Unel, M; Karchin, P E; Kartal, S; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, M S; Kim, S B; Kim, S H; Kim, T H; Kim, Y K; King, B T; Kirby, M; Kirsch, L; Klimenko, S; Knuteson, B; Ko, B R; Kobayashi, H; Koehn, P; Kong, D J; Kondo, K; Konigsberg, J; Kordas, K; Korn, A; Korytov, A; Kotelnikov, K; Kotwal, A V; Kovalev, A; Kraus, J; Kravchenko, I; Kreymer, A; Kroll, J; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, J; Lancaster, M; Lander, R; Lannon, K; Lath, A; Latino, G; Lauhakangas, R; Lazzizzera, I; Le, Y; Lecci, C; LeCompte, T; Lee, J; Lee, J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Li, K; Lin, C; Lin, C S; Lindgren, M; Liss, T M; Lister, A; Litvintsev, D O; Liu, T; Liu, Y; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P; Lu, R-S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; MacQueen, D; Madrak, R; Maeshima, K; Maksimovic, P; Malferrari, L; Manca, G; Marginean, R; Marino, C; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Matsunaga, H; Mattson, M; Mazzanti, P; McFarland, K S; McGivern, D; McIntyre, P M; McNamara, P; NcNulty, R; Mehta, A; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miller, L; Miller, R; Miller, J S; Miquel, R; Miscetti, S; Mitselmakher, G; Miyamoto, A; Miyazaki, Y; Moggi, N; Mohr, B; Moore, R; Morello, M; Movilla Fernandez, P A; Mukherjee, A; Mulhearn, M; Muller, T; Mumford, R; Munar, A; Murat, P; Nachtman, J; Nahn, S; Nakamura, I; Nakano, I; Napier, A; Napora, R; Naumov, D; Necula, V; Niell, F; Nielsen, J; Nelson, C; Nelson, T; Neu, C; Neubauer, M S; Newman-Holmes, C; Nigmanov, T; Nodulman, L; Norniella, O; Oesterberg, K; Ogawa, T; Oh, S H; Oh, Y D; Ohsugi, T; Okusawa, T; Oldeman, R; Orava, R; Orejudos, W; Pagliarone, C; Palencia, E; Paoletti, R; Papadimitriou, V; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Pauly, T; Paus, C; Pellett, D; Penzo, A; Phillips, T J; Piacentino, G; Piedra, J; Pitts, K T; Plager, C; Pompos, A; Pondrom, L; Pope, G; Portell, X; Poukhov, O; Prakoshyn, F; Pratt, T; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Rademachker, J; Rahaman, M A; Rakitine, A; Rappoccio, S; Ratnikov, F; Ray, H; Reisert, B; Rekovic, V; Renton, P; Rescigno, M; Rimondi, F; Rinnert, K; Ristori, L; Robertson, W J; Robson, A; Rodrigo, T; Rolli, S; Rosenson, L; Roser, R; Rossin, R; Rott, C; Russ, J; Rusu, V; Ruiz, A; Ryan, D; Saarikko, H; Sabik, S; Safonov, A; St Denis, R; Sakumoto, W K; Salamanna, G; Saltzberg, D; Sanchez, C; Sansoni, A; Santi, L; Sarkar, S; Sato, K; Savard, P; Savoy-Navarro, A; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Scodellaro, L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semeria, F; Sexton-Kennedy, L; Sfiligoi, I; Shapiro, M D; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Siegrist, J; Siket, M; Sill, A; Sinervo, P; Sisakyan, A; Skiba, A; Slaughter, A J; Sliwa, K; Smirnov, D; Smith, J R; Snider, F D; Snihur, R; Soha, A; Somalwar, S V; Spalding, J; Spezziga, M; Spiegel, L; Spinella, F; Spiropulu, M; Squillacioti, P; Stadie, H; Stelzer, B; Stelzer-Chilton, O; Strologas, J; Stuart, D; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Taffard, A; Tafirout, R; Takach, S F; Takano, H; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tanimoto, N; Tapprogge, S; Tecchio, M; Teng, P K; Terashi, K; Tesarek, R J; Tether, S; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Trkaczyk, S; Toback, D; Tollefson, K; Tomura, T; Tonelli, D; Tönnesmann, M; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tseng, J; Tsuchiya, R; Tsuno, S; Tsybychev, D; Turini, N; Turner, M; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vacavant, L; Vaiciulis, A; Varganov, A; Vataga, E; Vejcik, S; Velev, G; Veszpremi, V; Veramendi, G; Vickey, T; Vidal, R; Vila, I; Vilar, R; Vollrath, I; Volobouev, I; von der Mey, M; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wallny, R; Walter, T; Yamashita, T; Yamamoto, K; Wan, Z; Wang, M J; Wang, S M; Warburton, A; Ward, B; Waschke, S; Waters, D; Watts, T; Weber, M; Wester, W C; Whitehouse, B; Wicklund, A B; Wicklund, E; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolter, M; Worcester, M; Worm, S; Wright, T; Wu, X; Würthwein, F; Wyatt, A; Yagil, A; Yang, C; Yang, U K; Yao, W; Yeh, G P; Yi, K; Yoh, J; Yoon, P; Yorita, K; Yoshida, T; Yu, I; Yu, S; Yu, Z; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhou, J; Zsenei, A; Zucchelli, S

    2005-07-08

    We report on a search for anomalous kinematics of tt dilepton events in pp collisions at square root of s=1.96 TeV using 193 pb(-1) of data collected with the CDF II detector. We developed a new a priori technique designed to isolate the subset in a data sample revealing the largest deviation from standard model (SM) expectations and to quantify the significance of this departure. In the four-variable space considered, no particular subset shows a significant discrepancy, and we find that the probability of obtaining a data sample less consistent with the SM than what is observed is 1.0%-4.5%.

  11. Mechanical and Thermal Characterisation of a TT Half-Module Prototype

    CERN Document Server

    Lehner, F; Pangilinan, M; Siegler, M

    2005-01-01

    This note describes the mechanical effects of thermal cycles on a TT half-module, to demonstrate that the detectors can withstand the expected thermal gradients without damage. The stress transferred by the carbon fiber rails and the ceramic to the silicon sensors was investigated, and the deformation that occurred during these tests was measured by strain gauges that were attached to sensors on a test half-module. In addition, heat transfer through the carbon fiber rails was studied. Furthermore, we present a comparison of different materials proposed to build the carbon fiber rails of the modules.

  12. Alignment Compensation for Bending Radius in TT40 and TI 8 Transfer Line Magnets

    CERN Document Server

    Weterings, W

    2003-01-01

    The BEATCH file for the TI 8 transfer lines specifies the position of the bending magnets assuming that the beam enters and exits at the centre of the vacuum pipe. In order to distribute the deflected beam evenly inside the vacuum tube, the alignment has to be compensated by moving the magnets half of the beam deflection away from the centre of the bending radius. In this note the saggitas of the various TT40 and TI 8 magnets are calculated and the alignment displacements tabulated for future reference.

  13. Rare processes with top quarks: FCNCs, tt+X, tttt, t+X

    CERN Document Server

    Li, Yichen; The ATLAS collaboration

    2018-01-01

    The latest ATLAS and CMS searches or measurements of rare processes with top quarks, including FCNCs, tt+X, tttt, and t+X, are presented. FCNC branching ratio limits are pushed to new low, with some of them even reaching the expected limits for some BSMs. Associated production of W/Z/photon with a pair of top quarks are established and their cross sections are measured. The evidence of associated production of Z boson with a top quark is found. While there is no evidence for the four top quark production yet.

  14. Randomized Trial to Compare the Immunogenicity and Safety of a CRM or TT Conjugated Quadrivalent Meningococcal Vaccine in Teenagers who Received a CRM or TT Conjugated Serogroup C Vaccine at Preschool Age.

    Science.gov (United States)

    Ishola, David A; Andrews, Nick; Waight, Pauline; Yung, Chee-Fu; Southern, Jo; Bai, Xilian; Findlow, Helen; Matheson, Mary; England, Anna; Hallis, Bassam; Findlow, Jamie; Borrow, Ray; Miller, Elizabeth

    2015-08-01

    Protection after meningococcal C (MenC) conjugate (MCC) vaccination in early childhood is short-lived. Boosting with a quadrivalent vaccine in teenage years, a high-risk period for MenC disease, should protect against additional serogroups but might compromise MenC response. The carrier protein in the primary MCC vaccine determines the response to MCC booster in toddlers, but the relationship between primary vaccine and booster given later is unclear. This study compared responses to a CRM-conjugated or tetanus toxoid (TT)-conjugated MenACWY vaccine in teenagers primed with different MCC vaccines at preschool age. Ninety-three teenagers (16-19 years), who were previously randomized at age 3-6 years to receive single-dose MCC-CRM or MCC-TT, were randomized to receive either MenACWY-CRM or MenACWY-TT booster. Serum bactericidal antibodies (SBA, protective titer ≥ 8) were measured before, 1 month and 6 or 9 months after boosting. Preboosting, MCC-TT-primed teenagers had significantly higher MenC SBA titers than those MCC-CRM-primed (P = 0.02). Postboosting, both MenACWY vaccines induced protective SBA titers to all 4 serogroups in most participants (≥ 98% at 1 month and ≥ 90% by 9 months postboost). The highest MenC SBA titers were seen in those MCC-TT-primed and MenACWY-TT-boosted [geometric mean titer (GMT) ~ 22,000] followed by those boosted with MenACWY-CRM irrespective of priming (GMT ~ 12,000) and then those MCC-CRM-primed and MenACWY-TT-boosted (GMT ~ 5500). The estimated postbooster MenC SBA decline beyond 1 month was ~40% as time since booster doubles. Both vaccines were well tolerated with no attributable serious adverse events. Both MenACWY vaccines safely induced protective sustained antibody responses against all targeted serogroups in MCC-primed teenagers.

  15. The physiological mechanisms of performance enhancement with sprint interval training differ between the upper and lower extremities in humans.

    Directory of Open Access Journals (Sweden)

    Christoph Zinner

    2016-09-01

    Full Text Available To elucidate the mechanisms underlying the differences in adaptation of arm and leg muscles to sprint training, over a period of 11 days 16 untrained men performed six sessions of 4-6x30-sec all-out sprints (SIT with the legs and arms, separately, with a 1-h interval of recovery. Limb-specific VO2peak, sprint performance (two 30-sec Wingate tests with 4-min recovery, muscle efficiency and time-trial performance (TT, 5-min all-out were assessed and biopsies from the m. vastus lateralis and m. triceps brachii taken before and after training. VO2peak and Wmax increased 3-11% after training, with a more pronounced change in the arms (P < 0.05. Gross efficiency improved for the arms (+8.8%, P < 0.05, but not the legs (-0.6%. Wingate peak and mean power outputs improved similarly for the arms and legs, as did TT performance. After training, VO2 during the two Wingate tests was increased by 52% and 6% for the arms and legs, respectively (P < 0.001. In the case of the arms, VO2 was higher during the first than second Wingate test (64% vs. 44%, P < 0.05. During the TT, relative exercise intensity, HR, VO2, VCO2, VE, and Vt were all lower during arm-cranking than leg-pedaling, and oxidation of fat was minimal, remaining so after training. Despite the higher relative intensity, fat oxidation was 70% greater during leg-pedaling (P = 0.017. The aerobic energy contribution in the legs was larger than for the arms during the Wingate tests, although VO2 for the arms was enhanced more by training, reducing the O2 deficit after SIT. The levels of muscle glycogen, as well as the myosin heavy chain composition were unchanged in both cases, while the activities of 3-hydroxyacyl-CoA-dehydrogenase and citrate synthase were elevated only in the legs and capillarization enhanced in both limbs. Multiple regression analysis demonstrated that the variables that predict TT performance differ for the arms and legs. The primary mechanism of adaptation to SIT by both the arms

  16. Measurement of the top-Yukawa coupling and the search for ttH production

    CERN Document Server

    Vasquez, Jared; The ATLAS collaboration

    2015-01-01

    To test whether the observed Higgs boson follows the predictions of the SM, careful study and measurement of its properties are necessary. Due to the top quark's large mass, a measurement of the top-Yukawa coupling (Y_t) is paramount to an understanding of EWSB and could provide a viable probe for new physics. While most production processes provide only an indirect measurement of Y_t via loop effects, the ttH and tH production allow for a direct tree-level measurement of the coupling strength (which could differ due to new physics contamination). The ttH process is probed through various Higgs decay channels with several advantages. The H->bb channel allows for a coupling measurement of both 3rd generation quarks while profiting from the largest Higgs branching ratio. The h->γγ channel has a much smaller branching ratio but benefits from a fine diphoton mass resolution. The process is also probed in the multilepton channel, which is targeted at the off-shell Higgs coupling of H->WW* and H->ZZ* as well as t...

  17. First ATLAS results on ttH at 13 TeV

    CERN Document Server

    Nektarijevic, Snezana; The ATLAS collaboration

    2017-01-01

    To understand the nature of the Higgs boson discovered with the LHC experiments ATLAS and CMS in 2012, it is important to search for the yet unobserved Higgs production and decay modes predicted by the Standard Model (SM) of particle physics. Associated production of the Higgs boson and a top-antitop quark pair (ttH production) is one of the yet unobserved processes, with a unique property that it offers a tree-level access to measuring the Higgs-top Yukawa coupling. With a predicted numerical value close to unity, this coupling plays a pivotal role in the stability of the Higgs potential at high energy scales, and also represents the most promising portal to searches for New Physics through fine deviations from the SM predictions. To maximise the chance to observe the SM ttH production, that makes only 1% of the total Higgs boson production cross-section in proton-proton (pp) collisions at the centre of mass energy of 13 TeV, it is necessary to exploit all accessible and sensitive final states. Due to the ri...

  18. Die vrou in T.T. Cloete se 'toepasslngs van dante'

    Directory of Open Access Journals (Sweden)

    R. Ward

    1998-04-01

    Full Text Available Woman in T.T. Cloete’s 'toepasslngs van dante' In T.T. Cloete's fourth collection of poems, Idiolek (1986, several references are made to the poetry of Dante Alighieri. At the core of this collection are three poems under the heading "toepassings van dante". The first, "Silhoeët van Beatrice", is a description of the outline of Beatrice's naked body. The second poem, "mooi marilyn monroe foto in rooi", is based on a pin-up of Marilyn Monroe posing naked against a backdrop of red velvet. Although these two women are almost exact opposites - Beatrice possessing a divine beauty and an almost Christ-like nature, whereas Marilyn Monroe is portrayed as a dumb blonde and sex symbol of the fifties - the two poems are suspiciously similar in style and content. Both women are portrayed as being fundamentally perfect ("fundamenteel perfek". In symbolizing the same virtues, they lose their unique and contrasting characteristics, and merge into a symbol of female perfection. Although the third poem, "columbae", does not have the Beatrice/Marilyn Monroe-figure as subject matter, it can be read as dealing with the issue of individuality and uniqueness, thus commenting on the previous two poems.

  19. Positive cooperativity of the specific binding between Hg2+ ion and T:T mismatched base pairs in duplex DNA

    International Nuclear Information System (INIS)

    Torigoe, Hidetaka; Miyakawa, Yukako; Ono, Akira; Kozasa, Tetsuo

    2012-01-01

    Highlights: ► Hg 2+ specifically bound with the T:T mismatched base pair at 1:1 molar ratio. ► The binding constant between Hg 2+ and the T:T mismatched base pair was 10 6 M −1 . ► The binding constant was larger than those for nonspecific metal–DNA interactions. ► The binding constant for the second Hg 2+ was larger than that for the first Hg 2+ . ► The positive cooperative binding was observed between Hg 2+ and multiple T:T. - Abstract: Metal-mediated base pairs by the interaction between metal ions and artificial bases in oligonucleotides have been developed for their potential applications in nanotechnology. We recently found that a natural T:T mismatched base pair bound with Hg 2+ ion to form a novel T–Hg–T base pair. Here, we examined the thermodynamic properties of the binding between Hg 2+ and each of the single and double T:T mismatched base pair duplex DNAs by isothermal titration calorimetry. Hg 2+ specifically bound with the T:T mismatched base pair at 1:1 molar ratio with 10 6 M −1 binding constant, which was significantly larger than those for nonspecific metal ion–DNA interactions. In the Hg 2+ –double T:T mismatched base pair interaction, the affinity for the second Hg 2+ binding was significantly larger than that for the first Hg 2+ binding. The positively cooperative binding may be favorable to align multiple Hg 2+ in duplex DNA for the application of the metal-mediated base pairs in nanotechnology.

  20. Boiling water reactor turbine trip (TT) benchmark. Volume II: Summary Results of Exercise 1

    International Nuclear Information System (INIS)

    Akdeniz, Bedirhan; Ivanov, Kostadin N.; Olson, Andy M.

    2005-06-01

    The OECD Nuclear Energy Agency (NEA) completed under US Nuclear Regulatory Commission (NRC) sponsorship a PWR main steam line break (MSLB) benchmark against coupled system three-dimensional (3-D) neutron kinetics and thermal-hydraulic codes. Another OECD/NRC coupled-code benchmark was recently completed for a BWR turbine trip (TT) transient and is the object of the present report. Turbine trip transients in a BWR are pressurisation events in which the coupling between core space-dependent neutronic phenomena and system dynamics plays an important role. The data made available from actual experiments carried out at the Peach Bottom 2 plant make the present benchmark particularly valuable. While defining and coordinating the BWR TT benchmark, a systematic approach and level methodology not only allowed for a consistent and comprehensive validation process, but also contributed to the study of key parameters of pressurisation transients. The benchmark consists of three separate exercises, two initial states and five transient scenarios. The BWR TT Benchmark will be published in four volumes as NEA reports. CD-ROMs will also be prepared and will include the four reports and the transient boundary conditions, decay heat values as a function of time, cross-section libraries and supplementary tables and graphs not published in the paper version. BWR TT Benchmark - Volume I: Final Specifications was issued in 2001 [NEA/NSC/DOC(2001)]. The benchmark team [Pennsylvania State University (PSU) in co-operation with Exelon Nuclear and the NEA] has been responsible for coordinating benchmark activities, answering participant questions and assisting them in developing their models, as well as analysing submitted solutions and providing reports summarising the results for each phase. The benchmark team has also been involved in the technical aspects of the benchmark, including sensitivity studies for the different exercises. Volume II summarises the results for Exercise 1 of the

  1. Search for the Higgs boson in the tt-bar H(H→bb-bar) channel and the identification of jets containing 2 B hadrons with the ATLAS experiment

    International Nuclear Information System (INIS)

    Ticse Torres, R.E.

    2016-01-01

    In July 2012, CERN announced the discovery of the Higgs boson, the last missing piece of the Standard Model (SM). The Higgs boson has been observed coupling directly to W and Z bosons and tau leptons, and indirectly to top quarks. Observing the Higgs boson production in association with a pair of top quarks (tt-bar H) would allow a direct measurement of the top quark Yukawa coupling and provides an important test of the Higgs mechanism within the SM. This thesis presents a search for the Higgs boson in the tt-bar H(H→ bb-bar) channel using proton-proton collisions at √s=13 TeV, collected with the ATLAS detector in 2015 and 2016. The Higgs boson decays to two b quarks and top quark pair decays with one lepton, the tt-bar H → (lνb)(jjb)(bb-bar) single lepton channel, are considered. This document details in particular the contributions made by the author in this search: the full reconstruction of the tt-bar H(H → bb-bar) single lepton system and the final discrimination between signal and the main background, tt-bar+jets. A new method was developed to solve the large combinatorial background by fully reconstructing the tt-bar H(H → bb-bar) final state using a multivariate technique to uniquely associate each reconstructed jets to the initial quarks. A multivariate technique was also used to discriminate between the signal and the main tt-bar+jets background further increasing the sensitivity of the search compared to the Run 1 analysis. Finally, the first result at √s=13 TeV shown. The signal strength (the ratio between the measured and predicted cross sections) is found to be 1.6 ± 1.1. No significant excess of events above the background expectation is found and an observed (expected) limit of 3.6 (2.2) is set at 95% confidence level. The tt-bar bb-bar is one of the main backgrounds for the tt-bar H(bb-bar) search. Recent studies with Monte Carlo events generators show that there is a large fraction of tt-bar bb-bar events with jets containing two b

  2. Effect of the length of inflation on angular TT and TE power spectra in power-law inflation

    International Nuclear Information System (INIS)

    Hirai, Shiro; Takami, Tomoyuki

    2006-01-01

    The effect of the length of inflation on the power spectra of scalar and tensor perturbations is estimated using the power-law inflation model with a scale factor of a(η) = (-η) p = t q . Considering various pre-inflation models with radiation-dominated or scalar matter-dominated periods before inflation in combination with two matching conditions, the temperature angular power spectrum (TT) and temperature-polarization cross-power spectrum (TE) are calculated and a likelihood analysis is performed. It is shown that the discrepancies between the Wilkinson microwave anisotropy probe (WMAP) data and the ΛCDM model, such as suppression of the spectrum at l = 2, 3 and oscillatory behaviour, may be explained by the finite length of inflation model if the length of inflation is near 60 e-folds and q ≥ 300. The proposed models retain similar values of χ 2 to that achieved by the ΛCDM model with respect to fit to the WMAP data, but display different characteristics of the angular TE power spectra at l ≤ 20

  3. Effects of 90-day feeding of transgenic Bt rice TT51 on the reproductive system in male rats.

    Science.gov (United States)

    Wang, Er Hui; Yu, Zhou; Hu, Jing; Xu, Hai Bin

    2013-12-01

    Rice is a staple food crop; however, the threat of pests leads to a serious decline in its output and quality. The CryAb/CryAc gene, encodes a synthetic fusion Bacillus thuringiensis (Bt) crystal protein, was introduced into rice MingHui63 to produce insect-resistant rice TT51. This study was undertaken to investigate potential unintended effects of TT51 on the reproductive system in male rats. Male rats were treated with diets containing 60% of either TT51 or MingHui63 by weight, nutritionally balanced to an AIN93G diet, for 90days. An additional negative control group of rats were fed with a rice-based AIN93G diet. Body weights, food intake, hematology, serum chemistry, serum hormone levels, sperm parameters and relative organ/body weights were measured, and gross as well as microscopic pathology were examined. No diet-related significant differences in the values of response variables were observed between rats that were fed with diet containing transgenic TT51, MingHui63 and the control in this 90-day feeding study. In addition, necropsy and histopathology examination indicated no treatment-related changes. The results from the present study indicated that TT51 does not appear to exert any effect on the reproductive system in male rats compared with MingHui63 or the control. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. Caffeine increases anaerobic work and restores cycling performance following a protocol designed to lower endogenous carbohydrate availability.

    Directory of Open Access Journals (Sweden)

    Marcos David Silva-Cavalcante

    Full Text Available The purpose this study was to examine the effects of caffeine ingestion on performance and energy expenditure (anaerobic and aerobic contribution during a 4-km cycling time trial (TT performed after a carbohydrate (CHO availability-lowering exercise protocol. After preliminary and familiarization trials, seven amateur cyclists performed three 4-km cycling TT in a double-blind, randomized and crossover design. The trials were performed either after no previous exercise (CON, or after a CHO availability-lowering exercise protocol (DEP performed in the previous evening, followed by either placebo (DEP-PLA or 5 mg.kg(-1 of caffeine intake (DEP-CAF 1 hour before the trial. Performance was reduced (-2.1% in DEP-PLA vs CON (421.0±12.3 vs 412.4±9.7 s. However, performance was restored in DEP-CAF (404.6±17.1 s compared with DEP-PLA, while no differences were found between DEP-CAF and CON. The anaerobic contribution was increased in DEP-CAF compared with both DEP-PLA and CON (67.4±14.91, 47. 3±14.6 and 55.3±14.0 W, respectively, and this was more pronounced in the first 3 km of the trial. Similarly, total anaerobic work was higher in DEP-CAF than in the other conditions. The integrated electromyographic activity, plasma lactate concentration, oxygen uptake, aerobic contribution and total aerobic work were not different between the conditions. The reduction in performance associated with low CHO availability is reversed with caffeine ingestion due to a higher anaerobic contribution, suggesting that caffeine could access an anaerobic "reserve" that is not used under normal conditions.

  5. Caffeine Increases Anaerobic Work and Restores Cycling Performance following a Protocol Designed to Lower Endogenous Carbohydrate Availability

    Science.gov (United States)

    Silva-Cavalcante, Marcos David; Correia-Oliveira, Carlos Rafaell; Santos, Ralmony Alcantara; Lopes-Silva, João Paulo; Lima, Hessel Marani; Bertuzzi, Romulo; Duarte, Marcos; Bishop, David John; Lima-Silva, Adriano Eduardo

    2013-01-01

    The purpose this study was to examine the effects of caffeine ingestion on performance and energy expenditure (anaerobic and aerobic contribution) during a 4-km cycling time trial (TT) performed after a carbohydrate (CHO) availability-lowering exercise protocol. After preliminary and familiarization trials, seven amateur cyclists performed three 4-km cycling TT in a double-blind, randomized and crossover design. The trials were performed either after no previous exercise (CON), or after a CHO availability-lowering exercise protocol (DEP) performed in the previous evening, followed by either placebo (DEP-PLA) or 5 mg.kg−1 of caffeine intake (DEP-CAF) 1 hour before the trial. Performance was reduced (−2.1%) in DEP-PLA vs CON (421.0±12.3 vs 412.4±9.7 s). However, performance was restored in DEP-CAF (404.6±17.1 s) compared with DEP-PLA, while no differences were found between DEP-CAF and CON. The anaerobic contribution was increased in DEP-CAF compared with both DEP-PLA and CON (67.4±14.91, 47. 3±14.6 and 55.3±14.0 W, respectively), and this was more pronounced in the first 3 km of the trial. Similarly, total anaerobic work was higher in DEP-CAF than in the other conditions. The integrated electromyographic activity, plasma lactate concentration, oxygen uptake, aerobic contribution and total aerobic work were not different between the conditions. The reduction in performance associated with low CHO availability is reversed with caffeine ingestion due to a higher anaerobic contribution, suggesting that caffeine could access an anaerobic “reserve” that is not used under normal conditions. PMID:23977198

  6. Six Sessions of Sprint Interval Training Improves Running Performance in Trained Athletes.

    Science.gov (United States)

    Koral, Jerome; Oranchuk, Dustin J; Herrera, Roberto; Millet, Guillaume Y

    2018-03-01

    Koral, J, Oranchuk, DJ, Herrera, R, and Millet, GY. Six sessions of sprint interval training improves running performance in trained athletes. J Strength Cond Res 32(3): 617-623, 2018-Sprint interval training (SIT) is gaining popularity with endurance athletes. Various studies have shown that SIT allows for similar or greater endurance, strength, and power performance improvements than traditional endurance training but demands less time and volume. One of the main limitations in SIT research is that most studies were performed in a laboratory using expensive treadmills or ergometers. The aim of this study was to assess the performance effects of a novel short-term and highly accessible training protocol based on maximal shuttle runs in the field (SIT-F). Sixteen (12 male, 4 female) trained trail runners completed a 2-week procedure consisting of 4-7 bouts of 30 seconds at maximal intensity interspersed by 4 minutes of recovery, 3 times a week. Maximal aerobic speed (MAS), time to exhaustion at 90% of MAS before test (Tmax at 90% MAS), and 3,000-m time trial (TT3000m) were evaluated before and after training. Data were analyzed using a paired samples t-test, and Cohen's (d) effect sizes were calculated. Maximal aerobic speed improved by 2.3% (p = 0.01, d = 0.22), whereas peak power (PP) and mean power (MP) increased by 2.4% (p = 0.009, d = 0.33) and 2.8% (p = 0.002, d = 0.41), respectively. TT3000m was 6% shorter (p training in the field significantly improved the 3,000-m run, time to exhaustion, PP, and MP in trained trail runners. Sprint interval training in the field is a time-efficient and cost-free means of improving both endurance and power performance in trained athletes.

  7. Immunotoxicological Evaluation of Genetically Modified Rice Expressing Cry1Ab/Ac Protein (TT51-1) by a 6-Month Feeding Study on Cynomolgus Monkeys

    Science.gov (United States)

    Tan, Xiaoyan; Zhou, Xiaobing; Tang, Yao; Lv, Jianjun; Zhang, Lin; Sun, Li; Yang, Yanwei; Miao, Yufa; Jiang, Hua; Chen, Gaofeng; Huang, Zhiying; Wang, Xue

    2016-01-01

    The present study was performed to evaluate the food safety of TT51-1, a new type of genetically modified rice that expresses the Cry1Ab/Ac protein (Bt toxin) and is highly resistant to most lepidopteran pests. Sixteen male and 16 female cynomolgus monkeys were randomly divided into four groups: conventional rice (non-genetically modified rice, non-GM rice), positive control, 17.5% genetically modified rice (GM rice) and 70% GM rice. Monkeys in the non-GM rice, positive control, and GM rice groups were fed on diets containing 70% non-GM rice, 17.5% GM rice or 70% GM rice, respectively, for 182 days, whereas animals in the positive group were intravenously injected with cyclophosphamide every other day for a total of four injections before the last treatment. Six months of treatment did not yield abnormal observations. Specifically, the following parameters did not significantly differ between the non-GM rice group and GM rice groups: body weight, food consumption, electrocardiogram, hematology, immuno-phenotyping of lymphocytes in the peripheral blood, mitogen-induced peripheral blood lymphocyte proliferation, splenocyte proliferation, KLH-T cell-dependent antibody response, organ weights and ratios, and histological appearance (p>0.05). Animals from the GM rice group differed from animals in the non-GM rice group (pGM rice. In conclusion, a 6-month feeding study of TT51-1 did not show adverse immunotoxicological effects on cynomolgus monkeys. PMID:27684490

  8. Metabolic Responses to Sago and Soy Supplementations during Endurance Cycling Performance in the Heat

    Directory of Open Access Journals (Sweden)

    Daniel Tarmast

    2017-10-01

    Full Text Available This study examined the effects of Sago (Sa, Soy (So, combined iso–caloric Sago+Soy (SS supplementations during cycling on metabolic responses as compared to placebo (P in the heat (31℃, 70% relative humidity. Twelve well–trained male cyclists (Age: 19.0±5.6 yr, Height: 170.8±7.6 cm, Wight: 60.1±11.2 kg, and VO2max: 56.5±6.5 mL.kg-1.min-1 participated in four experimental trials. The design of the trials was a randomized single–blind, placebo–controlled crossover trail comprising 90 min of steady–state cycling on an ergometer at 60% of VO2max followed by a 20–km time trial performance (TT. The participants of the study were supplemented 5 times at 0, 20, 40, 60, and 80 minutes during the steady–state cycling. Sa, So, and SS supplements provided 7.5% Sago, 7.5% Soy, and 6.0% Sago + 1.5% Soy respectively. Plasma glucose concentrations (PG reached a peak at 60 min after ingestion of Sa and SS as compared to baseline. At the end of the TT, PG reduced significantly to the baseline level. Plasma insulin concentrations (PI increased in all trials, but reduced gradually to the baseline level. The concentration of plasma free fatty acids (FFA increased gradually during the steady–state cycling and TT, and FFA was significantly higher in the P and So than the Sa and SS trials. At the end of the steady–state cycling, the plasma lactate concentration (LACT reached its lowest concentrations and at the end of the TT was enhanced significantly in all trials. These results suggest that sago and soy supplements increase the PG and PI during endurance exercise in the heat. These data add to the growing body of knowledge concerning endurance athletes’ glycemic and insulinemic responses to carbohydrate consumptions during exercise in the heat.

  9. Categorization of the processes contributing to ttH(H→bb) using deep neural networks with the CMS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Rath, Yannik; Erdmann, Martin; Fischer, Benjamin; Fischer, Robert; Heidemann, Fabian; Quast, Thorben; Rieger, Marcel [III. Physikalisches Institut A, RWTH Aachen University (Germany)

    2016-07-01

    In ttH(H→bb) analyses, event categorization is introduced to simultaneously constrain signal and background processes. A common procedure is to categorize events according to both their jet and b-tag multiplicities. The separation power of this approach is limited by the b-tagging efficiency. Especially ttH(H→bb) events with their high b-tag multiplicities suffer from migrations to background categories. In this presentation, we explore deep neural networks (DNNs) as a method of categorizing events according to their jet multiplicity and a DNN event class hypothesis. DNNs have the advantage of being able to learn discriminating features from low level variables, e.g. kinematic properties, and are naturally suited for multiclass classification problems. We compare the ttH signal separation achieved with the DNN method with that of a common categorization approach.

  10. Effect of surface cold work on corrosion of Alloy 690TT in high temperature high pressure water

    International Nuclear Information System (INIS)

    Wang, J.; Zhang, Z.; Han, E.-H.; Ke, W.

    2009-01-01

    This paper aims to investigate the effect of surface cold work on corrosion of Alloy 690TT. The Alloy 690TT was mechanical ground and electro polished respectively and immersed in primary water at DO = 2 ppm and DH = 2.5ppm respectively. The microstructure of surface and the compositions and morphology of the surface film on Alloy 690TT after immersion test were studied using scanning electron microscopy (SEM), transmission electron microscopy (TEM), Auger electron spectroscopy (AES) and focused ion beam (FIB). The results showed that feather-like oxide with decorated polyhedral oxide formed on ground surface and needle-like oxide with decorated polyhedral oxide formed on electro-polished surface. (author)

  11. Presence and significance of TT virus in Danish patients on maintenance hemodialysis

    DEFF Research Database (Denmark)

    Boysen, Trine; Christensen, Jens K; Madsen, Chris D

    2003-01-01

    OBJECTIVES: To determine the prevalence of TT virus (TTV) in a population of Danish hemodialysis patients and evaluate possible relations between TTV infection and elevated levels of C-reactive protein (CRP) and hypo-response to treatment with erythropoietin (EPO). MATERIAL AND METHODS: Patients......-positive patients were significantly older than TTV-negative patients (p = 0.011). No relations were found between TTV infection and elevated levels of alanine aminotransferase (ALT) or CRP or hypo-response to EPO treatment. The mean hemoglobin concentration was 11.24 +/- 1.48 g/dl. Patients with a high TTV viral...... load had a lower level of hemoglobin (10.86 +/- 1.47 g/dl) than the others (p = 0.01). This trend suggested a positive relation between TTV infection and the number of blood transfusions. A restriction fragment length polymorphism assay suggested that patients were infected with different TTV strains...

  12. The IBA rhodotron TT1000: a very high power E-beam accelerator

    International Nuclear Information System (INIS)

    Abs, M.; Jongen, Y.; Poncelet, E.; Bol, J.-L.

    2004-01-01

    Due to the relatively low conversion efficiency of electrons into X-rays, the use of X-rays on an industrial basis requires high-power high-energy electron accelerators. Based on its experience acquired in the development of the Rhodotron (Nucl. Instrum. Methods B 40/41 (1989) 943; Nucl. Instrum. Methods B 79 (1993) 865), IBA has launched a few years ago a vigorous R and D program to develop such high-power electron accelerator devoted to X-ray industrial applications. This research program resulted in the TT1000 Rhodotron aimed at delivering 5 and 7 MeV electron beams with a current intensity of 100 mA. This project is now reaching its final phase with the qualification tests of the first prototype of this new machine

  13. Presence and significance of TT virus in Danish patients on maintenance hemodialysis

    DEFF Research Database (Denmark)

    Boysen, T.; Christensen, J. K.; Madsen, C. D.

    2003-01-01

    -positive patients were significantly older than TTV-negative patients (p = 0.011). No relations were found between TTV infection and elevated levels of alanine aminotransferase (ALT) or CRP or hypo-response to EPO treatment. The mean hemoglobin concentration was 11.24 +/- 1.48 g/dl. Patients with a high TTV viral...... load had a lower level of hemoglobin (10.86 +/- 1.47 g/dl) than the others (p = 0.01). This trend suggested a positive relation between TTV infection and the number of blood transfusions. A restriction fragment length polymorphism assay suggested that patients were infected with different TTV strains......Objectives: To determine the prevalence of TT virus (TTV) in a population of Danish hemodialysis patients and evaluate possible relations between TTV infection and elevated levels of C-reactive protein (CRP) and hypo-response to treatment with erythropoietin (EPO). Material and Methods: Patients...

  14. The role of iron uptake in pathogenicity and symbiosis in Photorhabdus luminescens TT01

    Directory of Open Access Journals (Sweden)

    Joyce Susan A

    2010-06-01

    Full Text Available Abstract Background Photorhabdus are Gram negative bacteria that are pathogenic to insect larvae whilst also having a mutualistic interaction with nematodes from the family Heterorhabditis. Iron is an essential nutrient and bacteria have different mechanisms for obtaining both the ferrous (Fe2+ and ferric (Fe3+ forms of this metal from their environments. In this study we were interested in analyzing the role of Fe3+ and Fe2+ iron uptake systems in the ability of Photorhabdus to interact with its invertebrate hosts. Results We constructed targeted deletion mutants of exbD, feoABC and yfeABCD in P. luminescens TT01. The exbD mutant was predicted to be crippled in its ability to obtain Fe3+ and we show that this mutant does not grow well in iron-limited media. We also show that this mutant was avirulent to the insect but was unaffected in its symbiotic interaction with Heterorhabditis. Furthermore we show that a mutation in feoABC (encoding a predicted Fe2+ permease was unaffected in both virulence and symbiosis whilst the divalent cation transporter encoded by yfeABCD is required for virulence in the Tobacco Hornworm, Manduca sexta (Lepidoptera but not in the Greater Wax Moth, Galleria mellonella (Lepidoptera. Moreover the Yfe transporter also appears to have a role during colonization of the IJ stage of the nematode. Conclusion In this study we show that iron uptake (via the TonB complex and the Yfe transporter is important for the virulence of P. luminescens to insect larvae. Moreover this study also reveals that the Yfe transporter appears to be involved in Mn2+-uptake during growth in the gut lumen of the IJ nematode. Therefore, the Yfe transporter in P. luminescens TT01 is important during colonization of both the insect and nematode and, moreover, the metal ion transported by this pathway is host-dependent.

  15. LHC vector resonance searches in the tt̄Z final state

    Energy Technology Data Exchange (ETDEWEB)

    Backović, Mihailo [Center for Cosmology, Particle Physics and Phenomenology - CP3,Universite Catholique de Louvain,Louvain-la-neuve (Belgium); Flacke, Thomas [Center for Theoretical Physics of the Universe, Institute for Basic Science (IBS),Daejeon (Korea, Republic of); Department of Physics, Korea University,Seoul 02841 (Korea, Republic of); Jain, Bithika [School of Physics, Korea Institute for Advanced Study,Seoul 02455 (Korea, Republic of); Lee, Seung J. [Department of Physics, Korea University,Seoul 02841 (Korea, Republic of); School of Physics, Korea Institute for Advanced Study,Seoul 02455 (Korea, Republic of)

    2017-03-23

    LHC searches for BSM resonances in l{sup +}l{sup −}, jj, tt̄,γγ and VV final states have so far not resulted in discovery of new physics. Current results set lower limits on mass scales of new physics resonances well into the O(1) TeV range, assuming that the new resonance decays dominantly to a pair of Standard Model particles. While the SM pair searches are a vital probe of possible new physics, it is important to re-examine the scope of new physics scenarios probed with such final states. Scenarios where new resonances decay dominantly to final states other than SM pairs, even though well theoretically motivated, lie beyond the scope of SM pair searches. In this paper we argue that LHC searches for (vector) resonances beyond two particle final states would be useful complementary probes of new physics scenarios. As an example, we consider a class of composite Higgs models, and identify specific model parameter points where the color singlet, electrically neutral vector resonance ρ{sub 0} decays dominantly not to a pair of SM particles, but to a fermionic top partner T{sub f1} and a top quark, with T{sub f1}→tZ. We show that dominant decays of ρ{sub 0}→T{sub f1}t in the context of Composite Higgs models are possible even when the decay channel to a pair of T{sub f1} is kinematically open. Our analysis deals with scenarios where both m{sub ρ} and m{sub T{sub f{sub 1}}} are of O(1) TeV, leading to highly boosted tt̄Z final state topologies. We show that the particular composite Higgs scenario we consider is discoverable at the LHC13 with as little as 30 fb{sup −1}, while being allowed by other existing experimental constraints.

  16. Immunogenicity and reactogenicity of Infanrix™ when co-administered with meningococcal MenACWY-TT conjugate vaccine in toddlers primed with MenHibrix™ and Pediarix™.

    Science.gov (United States)

    Leonardi, Michael; Latiolais, Thomas; Sarpong, Kwabena; Simon, Michael; Twiggs, Jerry; Lei, Paul; Rinderknecht, Stephen; Blatter, Mark; Bianco, Veronique; Baine, Yaela; Friedland, Leonard R; Baccarini, Carmen; Miller, Jacqueline M

    2015-02-11

    Co-administration of an investigational quadrivalent meningococcal serogroups A, C, W and Y tetanus toxoid conjugate vaccine (MenACWY-TT) with the fourth dose of diphtheria-tetanus-acellular pertussis vaccine (DTaP) at age 15-18 months was investigated in 3-dose Haemophilus influenzae type b-meningococcal serogroups C/Y conjugate vaccine (HibMenCY-TT)-primed toddlers. Infants were randomized (5:1) and primed at 2, 4 and 6 months of age with HibMenCY-TT and DTaP-hepatitis B-inactivated poliovirus (DTaP-HBV-IPV) vaccine, or Hib-TT and DTaP-HBV-IPV (Control). HibMenCY-TT+ DTaP-HBV-IPV vaccinees were re-randomized (2:2:1) to receive MenACWY-TT at 12-15 months and DTaP at 15-18 months (MenACWY-TT group); MenACWY-TT co-administered with DTaP at 15-18 months (Coad group); or HibMenCY-TT at 12-15 months and DTaP at 15-18 months (HibMenCY-TT group). Controls received DTaP at 15-18 months. Only children in the HibMenCY-TT group received a fourth dose of Hib conjugate vaccine due to Hib conjugate vaccine shortage at the time of the study. DTaP immunogenicity and reactogenicity were assessed one month post-vaccination. Pre-defined statistical non-inferiority criteria between Coad and Control groups were met for diphtheria, tetanus and filamentous haemagglutinin but not pertussis toxoid and pertactin. Following vaccination ≥99% of children had anti-diphtheria/anti-tetanus concentrations ≥1.0 IU/ml. Pertussis GMCs were lower in all investigational groups versus Control. In post hoc analyses, pertussis antibody concentrations were above those in infants following 3-dose DTaP primary vaccination in whom efficacy against pertussis was demonstrated (Schmitt, von König, et al., 1996; Schmitt, Schuind, et al., 1996). The reactogenicity profile of the Coad group was similar to DTaP administered alone. Routine booster DTaP was immunogenic with an acceptable safety profile when co-administered with MenACWY-TT vaccine in HibMenCY-TT-primed toddlers. These data support the

  17. Academic software development tools and techniques (Report on the 1st Workshop WASDeTT at ECOOP 2008)

    NARCIS (Netherlands)

    Wuyts, R.; Kienle, H.M.; Mens, K.; Brand, van den M.G.J.; Kuhn, A.; Eugster, P.

    2009-01-01

    The objective of the 1st International Workshop on Advanced Software Development Tools and Techniques (WASDeTT-1) was to provide interested researchers with a forum to share their tool building experiences and to explore how tools can be built more effectively and efficiently. The theme for this

  18. Top associated Higgs production in the ttH into multileptons channel with one tau lepton in ATLAS

    CERN Document Server

    Seifert, Frank

    2015-01-01

    The measurement of the Higgs boson and its cross-section in top associated production allows a direct measurement of the top quark Yukawa coupling at tree level. This can be compared with the indirect one in gluon-gluon-fusion production. The decay channel of the ttH system in the multilepton final state gives one of the largest sensitivities. The sub-channel focused on here is that with two same-charged light leptons (electrons or muons) and one $\\tau_{\\rm{had}}$: ttH$\\rightarrow$2l+1$\\tau_{\\rm{had}}$. An overview over the ttH to multileptons analysis is given and the selection and data-driven background estimation of the 2l+1$\\tau_{\\rm{had}}$ channel is described in more detail. The analysis includes a dataset of 20.3fb$^{-1}$ which has been recorded in LHC Run1 at a center-of-mass energy of $\\sqrt{s}=8$TeV with the ATLAS detector. With the recorded data set of Run1 no significant excess of events above the background expectation could be observed and the best fit for the ttH production cross section combin...

  19. The Physiological Mechanisms of Performance Enhancement with Sprint Interval Training Differ between the Upper and Lower Extremities in Humans

    Science.gov (United States)

    Zinner, Christoph; Morales-Alamo, David; Ørtenblad, Niels; Larsen, Filip J.; Schiffer, Tomas A.; Willis, Sarah J.; Gelabert-Rebato, Miriam; Perez-Valera, Mario; Boushel, Robert; Calbet, Jose A. L.; Holmberg, Hans-Christer

    2016-01-01

    To elucidate the mechanisms underlying the differences in adaptation of arm and leg muscles to sprint training, over a period of 11 days 16 untrained men performed six sessions of 4–6 × 30-s all-out sprints (SIT) with the legs and arms, separately, with a 1-h interval of recovery. Limb-specific VO2peak, sprint performance (two 30-s Wingate tests with 4-min recovery), muscle efficiency and time-trial performance (TT, 5-min all-out) were assessed and biopsies from the m. vastus lateralis and m. triceps brachii taken before and after training. VO2peak and Wmax increased 3–11% after training, with a more pronounced change in the arms (P training, VO2 during the two Wingate tests was increased by 52 and 6% for the arms and legs, respectively (P intensity, HR, VO2, VCO2, VE, and Vt were all lower during arm-cranking than leg-pedaling, and oxidation of fat was minimal, remaining so after training. Despite the higher relative intensity, fat oxidation was 70% greater during leg-pedaling (P = 0.017). The aerobic energy contribution in the legs was larger than for the arms during the Wingate tests, although VO2 for the arms was enhanced more by training, reducing the O2 deficit after SIT. The levels of muscle glycogen, as well as the myosin heavy chain composition were unchanged in both cases, while the activities of 3-hydroxyacyl-CoA-dehydrogenase and citrate synthase were elevated only in the legs and capillarization enhanced in both limbs. Multiple regression analysis demonstrated that the variables that predict TT performance differ for the arms and legs. The primary mechanism of adaptation to SIT by both the arms and legs is enhancement of aerobic energy production. However, with their higher proportion of fast muscle fibers, the arms exhibit greater plasticity. PMID:27746738

  20. Postexercise Glycogen Recovery and Exercise Performance is Not Significantly Different Between Fast Food and Sport Supplements.

    Science.gov (United States)

    Cramer, Michael J; Dumke, Charles L; Hailes, Walter S; Cuddy, John S; Ruby, Brent C

    2015-10-01

    A variety of dietary choices are marketed to enhance glycogen recovery after physical activity. Past research informs recommendations regarding the timing, dose, and nutrient compositions to facilitate glycogen recovery. This study examined the effects of isoenergetic sport supplements (SS) vs. fast food (FF) on glycogen recovery and exercise performance. Eleven males completed two experimental trials in a randomized, counterbalanced order. Each trial included a 90-min glycogen depletion ride followed by a 4-hr recovery period. Absolute amounts of macronutrients (1.54 ± 0.27 g·kg-1 carbohydrate, 0.24 ± 0.04 g·kg fat-1, and 0.18 ±0.03g·kg protein-1) as either SS or FF were provided at 0 and 2 hr. Muscle biopsies were collected from the vastus lateralis at 0 and 4 hr post exercise. Blood samples were analyzed at 0, 30, 60, 120, 150, 180, and 240 min post exercise for insulin and glucose, with blood lipids analyzed at 0 and 240 min. A 20k time-trial (TT) was completed following the final muscle biopsy. There were no differences in the blood glucose and insulin responses. Similarly, rates of glycogen recovery were not different across the diets (6.9 ± 1.7 and 7.9 ± 2.4 mmol·kg wet weight- 1·hr-1 for SS and FF, respectively). There was also no difference across the diets for TT performance (34.1 ± 1.8 and 34.3 ± 1.7 min for SS and FF, respectively. These data indicate that short-term food options to initiate glycogen resynthesis can include dietary options not typically marketed as sports nutrition products such as fast food menu items.

  1. Multi-disciplinary investigation of the tomb of Menna (TT69), Theban Necropolis, Egypt.

    Science.gov (United States)

    Vandenabeele, Peter; Garcia-Moreno, Renata; Mathis, François; Leterme, Kerstin; Van Elslande, Elsa; Hocquet, François-Philippe; Rakkaa, Saïd; Laboury, Dimitri; Moens, Luc; Strivay, David; Hartwig, Melinda

    2009-08-01

    The archaeometrical survey of the tomb of Menna (TT69), which took place in November-December 2007, is part of the extended research program that aims to study and preserve this tomb in all its aspects. Menna was a high official who served as an overseer of Cadastral surveys during the reigns of pharaohs Tuthmosis IV and Amenhotep III (ca. 1419-1370 BC). The research team aimed to gather information, in a totally non-destructive way, on the materials used and the painting techniques. The technical examinations included photography with normal and raking light, macrophotography, ultra-violet (UV) fluorescence photography, and microscopy. On selected points X-ray fluorescence (XRF) was combined with diffuse reflectance UV-spectrometry, near infrared (NIR) diffuse reflectance spectroscopy and Raman spectroscopy. The technical aspects as well as problems that are inherently associated with an interdisciplinary survey of this extent, are discussed. The project worked with a large team of people with different backgrounds and sensitive technical equipment. Working conditions were quite hostile, including elevated temperatures and dust hampering the examinations.

  2. Keto-adaptation enhances exercise performance and body composition responses to training in endurance athletes.

    Science.gov (United States)

    McSwiney, Fionn T; Wardrop, Bruce; Hyde, Parker N; Lafountain, Richard A; Volek, Jeff S; Doyle, Lorna

    2018-04-01

    Low-carbohydrate diets have recently grown in popularity among endurance athletes, yet little is known about the long-term (>4wk) performance implications of consuming a low-carbohydrate high fat ketogenic diet (LCKD) in well-trained athletes. Twenty male endurance-trained athletes (age 33±11y, body mass 80±11kg; BMI 24.7±3.1kg/m 2 ) who habitually consumed a carbohydrate-based diet, self-selected into a high-carbohydrate (HC) group (n=11, %carbohydrate:protein:fat=65:14:20), or a LCKD group (n=9, 6:17:77). Both groups performed the same training intervention (endurance, strength and high intensity interval training (HIIT)). Prior to and following successful completion of 12-weeks of diet and training, participants had their body composition assessed, and completed a 100km time trial (TT), six second (SS) sprint, and a critical power test (CPT). During post-intervention testing the HC group consumed 30-60g/h carbohydrate, whereas the LCKD group consumed water, and electrolytes. The LCKD group experienced a significantly greater decrease in body mass (HC -0.8kg, LCKD -5.9kg; P=0.006, effect size (ES): 0.338) and percentage body fat percentage (HC -0.7%, LCKD -5.2%; P=0.008, ES: 0.346). Fasting serum beta-hydroxybutyrate (βHB) significantly increased from 0.1 at baseline to 0.5mmol/L in the LCKD group (P=0.011, ES: 0.403) in week 12. There was no significant change in performance of the 100km TT between groups (HC -1.13min·s, LCKD -4.07min·s, P=0.057, ES: 0.196). SS sprint peak power increased by 0.8 watts per kilogram bodyweight (w/kg) in the LCKD group, versus a -0.1w/kg reduction in the HC group (P=0.025, ES: 0.263). CPT peak power decreased by -0.7w/kg in the HC group, and increased by 1.4w/kg in the LCKD group (P=0.047, ES: 0.212). Fat oxidation in the LCKD group was significantly greater throughout the 100km TT. Compared to a HC comparison group, a 12-week period of keto-adaptation and exercise training, enhanced body composition, fat oxidation during

  3. The TT genotype of the STAT4 rs7574865 polymorphism is associated with high disease activity and disability in patients with early arthritis.

    Directory of Open Access Journals (Sweden)

    Amalia Lamana

    Full Text Available BACKGROUND: The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis. In the present study, we investigated the effects of these genetic variants on disease activity and disability in patients with early arthritis. METHODOLOGY AND RESULTS: We studied 640 patients with early arthritis (76% women; median age, 52 years, recording disease-related variables every 6 months during a 2-year follow-up. HLA-DRB1 alleles were determined by PCR-SSO, while rs7574865 and rs2476601 were genotyped with the Taqman 5' allelic discrimination assay. Multivariate analysis was performed using generalized estimating equations for repeated measures. After adjusting for confounding variables such as gender, age and ACPA, the TT genotype of rs7574865 in STAT4 was associated with increased disease activity (DAS28 as compared with the GG genotype (β coefficient [95% confidence interval] = 0.42 [0.01-0.83], p = 0.044. Conversely, the presence of the T allele of rs2476601 in PTPN22 was associated with diminished disease activity during follow-up in a dose-dependent manner (CT genotype = -0.27 [-0.56- -0.01], p = 0.042; TT genotype = -0.68 [-1.64- -0.27], p = 0.162. After adjustment for gender, age and disease activity, homozygosity for the T allele of rs7574865 in STAT4 was associated with greater disability as compared with the GG genotype. CONCLUSIONS: Our data suggest that patients with early arthritis who are homozygous for the T allele of rs7574865 in STAT4 may develop a more severe form of the disease with increased disease activity and disability.

  4. The TT genotype of the STAT4 rs7574865 polymorphism is associated with high disease activity and disability in patients with early arthritis.

    Science.gov (United States)

    Lamana, Amalia; Balsa, Alejandro; Rueda, Blanca; Ortiz, Ana M; Nuño, Laura; Miranda-Carus, Maria Eugenia; Gonzalez-Escribano, Maria F; Lopez-Nevot, Miguel A; Pascual-Salcedo, Dora; Martin, Javier; González-Álvaro, Isidoro

    2012-01-01

    The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis. In the present study, we investigated the effects of these genetic variants on disease activity and disability in patients with early arthritis. We studied 640 patients with early arthritis (76% women; median age, 52 years), recording disease-related variables every 6 months during a 2-year follow-up. HLA-DRB1 alleles were determined by PCR-SSO, while rs7574865 and rs2476601 were genotyped with the Taqman 5' allelic discrimination assay. Multivariate analysis was performed using generalized estimating equations for repeated measures. After adjusting for confounding variables such as gender, age and ACPA, the TT genotype of rs7574865 in STAT4 was associated with increased disease activity (DAS28) as compared with the GG genotype (β coefficient [95% confidence interval] = 0.42 [0.01-0.83], p = 0.044). Conversely, the presence of the T allele of rs2476601 in PTPN22 was associated with diminished disease activity during follow-up in a dose-dependent manner (CT genotype = -0.27 [-0.56- -0.01], p = 0.042; TT genotype = -0.68 [-1.64- -0.27], p = 0.162). After adjustment for gender, age and disease activity, homozygosity for the T allele of rs7574865 in STAT4 was associated with greater disability as compared with the GG genotype. Our data suggest that patients with early arthritis who are homozygous for the T allele of rs7574865 in STAT4 may develop a more severe form of the disease with increased disease activity and disability.

  5. The Effect of Concurrent Plyometric Training Versus Submaximal Aerobic Cycling on Rowing Economy, Peak Power, and Performance in Male High School Rowers.

    Science.gov (United States)

    Egan-Shuttler, Julian D; Edmonds, Rohan; Eddy, Cassandra; O'Neill, Veronica; Ives, Stephen J

    2017-12-01

    Plyometric training has been shown to increase muscle power, running economy, and performance in athletes. Despite its use by rowing coaches, it is unknown whether plyometrics might improve rowing economy or performance. The purpose was to determine if plyometric training, in conjunction with training on the water, would lead to improved rowing economy and performance. Eighteen male high school rowers were assigned to perform 4 weeks of either plyometric training (PLYO, n = 9) or steady-state cycling below ventilatory threshold (endurance, E, n = 9), for 30 min prior to practice on the water (matched for training volume) 3 days per week. Rowing performance was assessed through a 500-m rowing time trial (TT) and peak rowing power (RP), while rowing economy (RE) was assessed by measuring the oxygen cost over four work rates (90, 120, 150, and 180 W). Rowing economy was improved in both PLYO and E (p  0.05). Finally, RP was moderately higher in the PLYO group post-training (E 569 ± 75 W, PLYO 629 ± 51 W, ES = 0.66) CONCLUSIONS: In a season when the athletes performed no rowing sprint training, 4 weeks of plyometric training improved the 500-m rowing performance and moderately improved peak power. This increase in performance may have been mediated by moderate improvements in rowing power, but not economy, and warrants further investigation.

  6. Development of certified matrix-based reference material of genetically modified rice event TT51-1 for real-time PCR quantification.

    Science.gov (United States)

    Jiang, Yu; Yang, Hui; Quan, Sheng; Liu, Yinan; Shen, Ping; Yang, Litao

    2015-09-01

    In 2009, the genetically modified (GM) rice event TT51-1 with an engineered insect resistance trait became the first GM rice event to be granted certification for safe production in China, and its derivative lines Bt 63 and Huahui No.1 are expected to be commercialized soon. The development of certified reference material (CRM) for TT51-1 is necessary to monitor and inspect the TT51-1 event and its derivates. In this work, we developed four matrix-based TT51-1 rice CRMs (TT51-1a, TT51-1b, TT51-1c, and TT51-1d) with different TT51-1 mass fraction ratios by blending seed powders of homozygous TT51-1 and its recipient cultivar Minghui 63. The between-bottle homogeneity and the within-bottle homogeneity were tested, and good results were obtained. The potential degradation during transportation and shelf life were evaluated, and demonstrated an expiration period of at least 36 months. The characterization values of the four TT51-1 CRMs based on the mass fraction ratio were 1000.000 ± 51.430 g/kg, 49.940 ± 4.620 g/kg, 9.990 ± 1.110 g/kg, and 4.990 ± 0.620 g/kg, respectively. The characterization values based on the copy number ratio were certified by digital PCR analysis as 97.442 ± 5.253 %, 4.851 ± 0.486 %, 1.042 ± 0.135 %, and 0.556 ± 0.073 %, respectively. These results suggested that the TT51-1 matrix-based CRMs developed are of high quality and can be used as potential calibrators for TT51-1 GM rice inspection and monitoring.

  7. Sulfation diffusion model for SO{sub 2} capture on the T-T sorbent at moderate temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Li, Y.R.; Yang, L.Z.; You, C.F.; Qi, H.Y. [Tsinghua University, Beijing (China)

    2009-07-15

    A sulfation model was developed for dry flue gas desulfurization (FGD) at moderate temperatures to describe the reaction characteristics of the T-T sorbent clusters and the fine CaO particles that fall off the sorbent grains in a circulating fluidized bed (CFB) reactor. The cluster model describes the calcium conversion and reaction rate for various size sorbent clusters. The sulfation reaction is first order with respect to the SO{sub 2} concentration above 973 K. The calcium conversion and reaction rate for the CaO particles were obtained by extrapolation. In the model for CaO particle, the reaction rate is linearly related to the calcium conversion and the SO{sub 2} concentration in the rapid reaction stage and linearly related only with the calcium conversion after the product layer forms. The sulfation model accurately describes the sulfation of the T-T sorbent flowing through a CFB reactor.

  8. Just-in-time tomography (JiTT): a new concept for image-guided radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Pang, G; Rowlands, J A [Toronto-Sunnybrook Regional Cancer Centre, 2075 Bayview Avenue, Toronto M4N 3M5 (Canada); Imaging Research, Sunnybrook and Women' s College Health Sciences Centre, Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto (Canada)

    2005-11-07

    Soft-tissue target motion is one of the main concerns in high-precision radiation therapy. Cone beam computed tomography (CBCT) has been developed recently to image soft-tissue targets in the treatment room and guide the radiation therapy treatment. However, due to its relatively long image acquisition time the CBCT approach cannot provide images of the target at the instant of the treatment and thus it is not adequate for imaging targets with intrafraction motion. In this note, a new approach for image-guided radiation therapy-just-in-time tomography (JiTT)-is proposed. Differing from CBCT, JiTT takes much less time to generate the needed tomographical, beam's-eye-view images of the treatment target at the right moment to guide the radiation therapy treatment. (note)

  9. Just-in-time tomography (JiTT): a new concept for image-guided radiation therapy

    International Nuclear Information System (INIS)

    Pang, G; Rowlands, J A

    2005-01-01

    Soft-tissue target motion is one of the main concerns in high-precision radiation therapy. Cone beam computed tomography (CBCT) has been developed recently to image soft-tissue targets in the treatment room and guide the radiation therapy treatment. However, due to its relatively long image acquisition time the CBCT approach cannot provide images of the target at the instant of the treatment and thus it is not adequate for imaging targets with intrafraction motion. In this note, a new approach for image-guided radiation therapy-just-in-time tomography (JiTT)-is proposed. Differing from CBCT, JiTT takes much less time to generate the needed tomographical, beam's-eye-view images of the treatment target at the right moment to guide the radiation therapy treatment. (note)

  10. Top associated Higgs production in the ttH to multileptons channel with one hadronic tau in ATLAS

    CERN Document Server

    Seifert, Frank; The ATLAS collaboration

    2015-01-01

    The measurement of the Higgs Boson and its cross-section in top associated production allows a direct measurement of the top quark Yukawa coupling at tree level. This can be compared with the indirect one in gluon-gluon-fusion production. The decay channel of the ttH system in the multilepton final state gives one of the largest sensitivities. The considered sub-channel is one with two same-charged light leptons (electrons or muons) and one hadronically decaying tau-lepton: ttH into 2l+1tau. This poster gives an overview of the analysis and explains in detail the data-driven background estimation of the non-reducible background processes. The analysis includes a dataset of 20.3 inverse fb which has been recorded in LHC Run I at a center-of-mass energy of 8 TeV with the ATLAS detector.

  11. Test beam measurement of the first prototype of the fast silicon pixel monolithic detector for the TT-PET project

    Science.gov (United States)

    Paolozzi, L.; Bandi, Y.; Benoit, M.; Cardarelli, R.; Débieux, S.; Forshaw, D.; Hayakawa, D.; Iacobucci, G.; Kaynak, M.; Miucci, A.; Nessi, M.; Ratib, O.; Ripiccini, E.; Rücker, H.; Valerio, P.; Weber, M.

    2018-04-01

    The TT-PET collaboration is developing a PET scanner for small animals with 30 ps time-of-flight resolution and sub-millimetre 3D detection granularity. The sensitive element of the scanner is a monolithic silicon pixel detector based on state-of-the-art SiGe BiCMOS technology. The first ASIC prototype for the TT-PET was produced and tested in the laboratory and with minimum ionizing particles. The electronics exhibit an equivalent noise charge below 600 e‑ RMS and a pulse rise time of less than 2 ns , in accordance with the simulations. The pixels with a capacitance of 0.8 pF were measured to have a detection efficiency greater than 99% and, although in the absence of the post-processing, a time resolution of approximately 200 ps .

  12. Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment

    International Nuclear Information System (INIS)

    Adeleye, Yeyejide; Andersen, Melvin; Clewell, Rebecca; Davies, Michael; Dent, Matthew; Edwards, Sue; Fowler, Paul; Malcomber, Sophie; Nicol, Beate; Scott, Andrew; Scott, Sharon; Sun, Bin; Westmoreland, Carl; White, Andrew; Zhang, Qiang; Carmichael, Paul L.

    2015-01-01

    specific chemical in a case study mode. This contribution represents a ‘work-in-progress’ and is meant to both highlight concepts that are well-developed and identify aspects of the overall process which require additional development. To guide our understanding of what a pathways-based risk assessment could look like in practice, we chose to work on a case study chemical (quercetin) with a defined human exposure and to bring a multidisciplinary team of chemists, biologists, modellers and risk assessors to work together towards a safety assessment. Our goal was to see if the in vitro dose response for quercetin could be sufficiently understood to construct a TT21C risk assessment without recourse to rodent carcinogenicity study data. The data presented include high throughput pathway biomarkers (p-H2AX, p-ATM, p-ATR, p-Chk2, p53, p-p53, MDM2 and Wip1) and markers of cell-cycle, apoptosis and micronuclei formation, plus gene transcription in HT1080 cells. Eighteen point dose response curves were generated using flow cytometry and imaging to determine the concentrations that resulted in significant perturbation. NOELs and BMDs were compared to the output from biokinetic modelling and the potential for in vitro to in vivo extrapolation explored. A first tier risk assessment was performed comparing the total quercetin concentration in the in vitro systems with the predicted total quercetin concentration in plasma and tissues. The shortcomings of this approach and recommendations for improvement are described. This paper therefore describes the current progress in an ongoing research effort aimed at providing a pathways-based, proof-of-concept in vitro-only safety assessment for a consumer use product

  13. Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment.

    Science.gov (United States)

    Adeleye, Yeyejide; Andersen, Melvin; Clewell, Rebecca; Davies, Michael; Dent, Matthew; Edwards, Sue; Fowler, Paul; Malcomber, Sophie; Nicol, Beate; Scott, Andrew; Scott, Sharon; Sun, Bin; Westmoreland, Carl; White, Andrew; Zhang, Qiang; Carmichael, Paul L

    2015-06-05

    chemical in a case study mode. This contribution represents a 'work-in-progress' and is meant to both highlight concepts that are well-developed and identify aspects of the overall process which require additional development. To guide our understanding of what a pathways-based risk assessment could look like in practice, we chose to work on a case study chemical (quercetin) with a defined human exposure and to bring a multidisciplinary team of chemists, biologists, modellers and risk assessors to work together towards a safety assessment. Our goal was to see if the in vitro dose response for quercetin could be sufficiently understood to construct a TT21C risk assessment without recourse to rodent carcinogenicity study data. The data presented include high throughput pathway biomarkers (p-H2AX, p-ATM, p-ATR, p-Chk2, p53, p-p53, MDM2 and Wip1) and markers of cell-cycle, apoptosis and micronuclei formation, plus gene transcription in HT1080 cells. Eighteen point dose response curves were generated using flow cytometry and imaging to determine the concentrations that resulted in significant perturbation. NOELs and BMDs were compared to the output from biokinetic modelling and the potential for in vitro to in vivo extrapolation explored. A first tier risk assessment was performed comparing the total quercetin concentration in the in vitro systems with the predicted total quercetin concentration in plasma and tissues. The shortcomings of this approach and recommendations for improvement are described. This paper therefore describes the current progress in an ongoing research effort aimed at providing a pathways-based, proof-of-concept in vitro-only safety assessment for a consumer use product. Copyright © 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  14. PolyWaTT: A polynomial water travel time estimator based on Derivative Dynamic Time Warping and Perceptually Important Points

    Science.gov (United States)

    Claure, Yuri Navarro; Matsubara, Edson Takashi; Padovani, Carlos; Prati, Ronaldo Cristiano

    2018-03-01

    Traditional methods for estimating timing parameters in hydrological science require a rigorous study of the relations of flow resistance, slope, flow regime, watershed size, water velocity, and other local variables. These studies are mostly based on empirical observations, where the timing parameter is estimated using empirically derived formulas. The application of these studies to other locations is not always direct. The locations in which equations are used should have comparable characteristics to the locations from which such equations have been derived. To overcome this barrier, in this work, we developed a data-driven approach to estimate timing parameters such as travel time. Our proposal estimates timing parameters using historical data of the location without the need of adapting or using empirical formulas from other locations. The proposal only uses one variable measured at two different locations on the same river (for instance, two river-level measurements, one upstream and the other downstream on the same river). The recorded data from each location generates two time series. Our method aligns these two time series using derivative dynamic time warping (DDTW) and perceptually important points (PIP). Using data from timing parameters, a polynomial function generalizes the data by inducing a polynomial water travel time estimator, called PolyWaTT. To evaluate the potential of our proposal, we applied PolyWaTT to three different watersheds: a floodplain ecosystem located in the part of Brazil known as Pantanal, the world's largest tropical wetland area; and the Missouri River and the Pearl River, in United States of America. We compared our proposal with empirical formulas and a data-driven state-of-the-art method. The experimental results demonstrate that PolyWaTT showed a lower mean absolute error than all other methods tested in this study, and for longer distances the mean absolute error achieved by PolyWaTT is three times smaller than empirical

  15. A new topical hemostatic agent TT-173 reduces blood loss in a sheep model of total knee arthroplasty.

    Science.gov (United States)

    Centeno, Alberto; Rojas, Santiago; Arias, Belén; Miquel, Ignasi; Sánchez, Pilar; Ureta, Claudia; Rincón, Esther; López, Ramón; Murat, Jesús

    2017-12-01

    Total knee arthroplasty is associated with blood loss during the intervention and may require allogenic blood transfusion. Treatments such as tranexamic acid and fibrin sealants improved the bleeding control in several clinical trials, but the hemorrhage associated with the intervention is still significant. Thus far, very few studies have evaluated hemostatic treatments in animal models of total knee arthroplasty. This work describes a sheep model of bleeding associated with total knee arthroplasty and investigates a new class of hemostatic treatment based on recombinant tissue factor. Sheep were treated with the anticoagulant heparin, and the joint was accessed by a paramedial incision. Ligaments and menisci were eliminated and femoral condyles and tibia plateau were sectioned exposing the trabecular bone. An intra-articular drain was used to recover and quantify the blood loss during the 90-min period after treatment. The efficacy of one milligram and three milligrams of TT-173 was evaluated and compared with tranexamic acid. The occurrence of analytical alterations and systemic absorption was also investigated. Treatment with TT-173 reduced the blood loss in comparison with control or tranexamic acid. No significant differences were observed between the two doses evaluated. Moreover, a dose of six milligrams of TT-173 did not induce any clinical or analytical alteration, and significant systemic absorption was not observed. Data obtained strongly suggest that TT-173 could be useful in reducing the blood loss associated with total knee arthroplasty and without safety concerns derived from the systemic absorption of the product. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Predictive uncertainty reduction in coupled neutron-kinetics/thermal hydraulics modeling of the BWR-TT2 benchmark

    Energy Technology Data Exchange (ETDEWEB)

    Badea, Aurelian F., E-mail: aurelian.badea@kit.edu [Karlsruhe Institute of Technology, Vincenz-Prießnitz-Str. 3, 76131 Karlsruhe (Germany); Cacuci, Dan G. [Center for Nuclear Science and Energy/Dept. of ME, University of South Carolina, 300 Main Street, Columbia, SC 29208 (United States)

    2017-03-15

    Highlights: • BWR Turbine Trip 2 (BWR-TT2) benchmark. • Substantial (up to 50%) reduction of uncertainties in the predicted transient power. • 6660 uncertain model parameters were calibrated. - Abstract: By applying a comprehensive predictive modeling methodology, this work demonstrates a substantial (up to 50%) reduction of uncertainties in the predicted total transient power in the BWR Turbine Trip 2 (BWR-TT2) benchmark while calibrating the numerical simulation of this benchmark, comprising 6090 macroscopic cross sections, and 570 thermal-hydraulics parameters involved in modeling the phase-slip correlation, transient outlet pressure, and total mass flow. The BWR-TT2 benchmark is based on an experiment that was carried out in 1977 in the NPP Peach Bottom 2, involving the closure of the turbine stop valve which caused a pressure wave that propagated with attenuation into the reactor core. The condensation of the steam in the reactor core caused by the pressure increase led to a positive reactivity insertion. The subsequent rise of power was limited by the feedback and the insertion of the control rods. The BWR-TT2 benchmark was modeled with the three-dimensional reactor physics code system DYN3D, by coupling neutron kinetics with two-phase thermal-hydraulics. All 6660 DYN3D model parameters were calibrated by applying a predictive modeling methodology that combines experimental and computational information to produce optimally predicted best-estimate results with reduced predicted uncertainties. Simultaneously, the predictive modeling methodology yields optimally predicted values for the BWR total transient power while reducing significantly the accompanying predicted standard deviations.

  17. Kas õpetajad on teie kaudu tööd otsinud? / Natalija Gansen, Merit Laan, Ilmar Kütt... [jt.

    Index Scriptorium Estoniae

    2010-01-01

    Küsimusele vastavad: Eesti töötukassa Tallinna ja Harjumaa osakonna teenusekonsultant Natalija Gansen, Eesti töötukassa Viljandimaa osakonna juhataja Merit Laan, Viljandi maavalitsuse haridus- ja sotsiaalosakonna juhataja Ilmar Kütt, CV-Online Estonia OÜ värbamisspetsialist Ivika Born, Lääne-Viru maavalitsuse haridus- ja sotsiaalosakonna vanemspetsialist Tiina Halling ja Valga maavalitsuse haridus- ja kultuuritalituse juhataja Kalle Vister

  18. Comparing Monte Carlo acceptance/efficiency for tt-bar single lepton events with central and plug electrons

    International Nuclear Information System (INIS)

    Rotaru, M.

    2005-01-01

    The tt-bar production using MC events with one charged lepton (electron), neutrino and jets from pp-bar collisions at a center-of-mass energy of 1.96 TeV was investigated. The aim of this work was to compare the rate of events in central (|η|<1.1) and plug (1.1<|η|<2.8) region. (author)

  19. Predictive uncertainty reduction in coupled neutron-kinetics/thermal hydraulics modeling of the BWR-TT2 benchmark

    International Nuclear Information System (INIS)

    Badea, Aurelian F.; Cacuci, Dan G.

    2017-01-01

    Highlights: • BWR Turbine Trip 2 (BWR-TT2) benchmark. • Substantial (up to 50%) reduction of uncertainties in the predicted transient power. • 6660 uncertain model parameters were calibrated. - Abstract: By applying a comprehensive predictive modeling methodology, this work demonstrates a substantial (up to 50%) reduction of uncertainties in the predicted total transient power in the BWR Turbine Trip 2 (BWR-TT2) benchmark while calibrating the numerical simulation of this benchmark, comprising 6090 macroscopic cross sections, and 570 thermal-hydraulics parameters involved in modeling the phase-slip correlation, transient outlet pressure, and total mass flow. The BWR-TT2 benchmark is based on an experiment that was carried out in 1977 in the NPP Peach Bottom 2, involving the closure of the turbine stop valve which caused a pressure wave that propagated with attenuation into the reactor core. The condensation of the steam in the reactor core caused by the pressure increase led to a positive reactivity insertion. The subsequent rise of power was limited by the feedback and the insertion of the control rods. The BWR-TT2 benchmark was modeled with the three-dimensional reactor physics code system DYN3D, by coupling neutron kinetics with two-phase thermal-hydraulics. All 6660 DYN3D model parameters were calibrated by applying a predictive modeling methodology that combines experimental and computational information to produce optimally predicted best-estimate results with reduced predicted uncertainties. Simultaneously, the predictive modeling methodology yields optimally predicted values for the BWR total transient power while reducing significantly the accompanying predicted standard deviations.

  20. A comparison of single and multiple aliquot TT-OSL data sets for sand-sized quartz from the Arabian Peninsula

    International Nuclear Information System (INIS)

    Rosenberg, T.M.; Preusser, F.; Wintle, A.G.

    2011-01-01

    The quartz OSL signal from dune sands from Saudi Arabia and Oman start to saturate at doses of about 100 Gy. In order to try to date dune sands with greater expected doses, a previously published, single-aliquot, regenerative-dose protocol (SAR) for thermally-transferred optically stimulated luminescence (TT-OSL) was tested. Dose recovery tests, recycling and recuperation ratios showed robust functioning and dose response curves demonstrated the potential to extend the dose range to beyond 600 Gy. Multiple aliquot additive dose (MAAD) TT-OSL protocols were used to test for sensitivity changes in the SAR TT-OSL protocol up to doses of 1200 Gy. A strong dose dependent deviation of the SAR TT-OSL relative to the MAAD TT-OSL dose response is observed. Comparison of the TT-OSL and OSL sensitivity data obtained from the MAAD and SAR data sets shows a lack of proportionality between TT-OSL and OSL for the SAR data which will result in a problem when SAR dose response curves are constructed using many regeneration points with doses above 300 Gy.

  1. The long-term effect of minimalist shoes on running performance and injury: design of a randomised controlled trial

    Science.gov (United States)

    Fuller, Joel T; Thewlis, Dominic; Tsiros, Margarita D; Brown, Nicholas A T; Buckley, Jonathan D

    2015-01-01

    Introduction The outcome of the effects of transitioning to minimalist running shoes is a topic of interest for runners and scientists. However, few studies have investigated the longer term effects of running in minimalist shoes. The purpose of this randomised controlled trial (RCT) is to investigate the effects of a 26 week transition to minimalist shoes on running performance and injury risk in trained runners unaccustomed to minimalist footwear. Methods and analysis A randomised parallel intervention design will be used. Seventy-six trained male runners will be recruited. To be eligible, runners must be aged 18–40 years, run with a habitual rearfoot footfall pattern, train with conventional shoes and have no prior experience with minimalist shoes. Runners will complete a standardised transition to either minimalist or control shoes and undergo assessments at baseline, 6 and 26 weeks. 5 km time-trial performance (5TT), running economy, running biomechanics, triceps surae muscle strength and lower limb bone mineral density will be assessed at each time point. Pain and injury will be recorded weekly. Training will be standardised during the first 6 weeks. Primary statistical analysis will compare 5TT between shoe groups at the 6-week time point and injury incidence across the entire 26-week study period. Ethics and dissemination This RCT has been approved by the Human Research Ethics Committee of the University of South Australia. Participants will be required to provide their written informed consent prior to participation in the study. Study findings will be disseminated in the form of journal publications and conference presentations after completion of planned data analysis. Trial registration number This RCT has been registered with the Australian New Zealand Clinical Trials Registry (ACTRN12613000642785). PMID:26297368

  2. Effects of Dietary Nitrate Supplementation on Physiological Responses, Cognitive Function, and Exercise Performance at Moderate and Very-High Simulated Altitude

    Directory of Open Access Journals (Sweden)

    Oliver M. Shannon

    2017-06-01

    Full Text Available Purpose: Nitric oxide (NO bioavailability is reduced during acute altitude exposure, contributing toward the decline in physiological and cognitive function in this environment. This study evaluated the effects of nitrate (NO3− supplementation on NO bioavailability, physiological and cognitive function, and exercise performance at moderate and very-high simulated altitude.Methods:Ten males (mean (SD: V˙O2max: 60.9 (10.1 ml·kg−1·min−1 rested and performed exercise twice at moderate (~14.0% O2; ~3,000 m and twice at very-high (~11.7% O2; ~4,300 m simulated altitude. Participants ingested either 140 ml concentrated NO3−-rich (BRJ; ~12.5 mmol NO3− or NO3−-deplete (PLA; 0.01 mmol NO3− beetroot juice 2 h before each trial. Participants rested for 45 min in normobaric hypoxia prior to completing an exercise task. Exercise comprised a 45 min walk at 30% V˙O2max and a 3 km time-trial (TT, both conducted on a treadmill at a 10% gradient whilst carrying a 10 kg backpack to simulate altitude hiking. Plasma nitrite concentration ([NO2−], peripheral oxygen saturation (SpO2, pulmonary oxygen uptake (V˙O2, muscle and cerebral oxygenation, and cognitive function were measured throughout.Results: Pre-exercise plasma [NO2−] was significantly elevated in BRJ compared with PLA (p = 0.001. Pulmonary V˙O2 was reduced (p = 0.020, and SpO2 was elevated (p = 0.005 during steady-state exercise in BRJ compared with PLA, with similar effects at both altitudes. BRJ supplementation enhanced 3 km TT performance relative to PLA by 3.8% [1,653.9 (261.3 vs. 1718.7 (213.0 s] and 4.2% [1,809.8 (262.0 vs. 1,889.1 (203.9 s] at 3,000 and 4,300 m, respectively (p = 0.019. Oxygenation of the gastrocnemius was elevated during the TT consequent to BRJ (p = 0.011. The number of false alarms during the Rapid Visual Information Processing Task tended to be lower with BRJ compared with PLA prior to altitude exposure (p = 0.056. Performance in all other cognitive tasks

  3. The mycobiota of the production environments of traditional Norwegian salted and dried mutton (pinnekjøtt).

    Science.gov (United States)

    Schirmer, Bjørn C T; Wiik-Nielsen, Jannicke; Skaar, Ida

    2018-07-02

    In 2013, mould growth on Norwegian ready-to-sell pinnekjøtt (dried and cured lamb ribs) lead to the withdrawal of 200 tons of the product. The aim of this study was to identify the mycobiota at two Norwegian production sites and determine which species present the highest risk for reduced product quality and safety. A total of 485 samples from 2014, 2015 and 2016 were analysed for Penicillium and Aspergillus species. Both production sites showed a persistent mycobiota that remained stable over three seasons. Samples from site A were dominated by P. solitum while samples from site B were equally dominated by P. solitum, P. brevicompactum/bialowiezense and P. nordicum. The presence of P. nordicum was concentrated in one area of the production site where long-time stored hams were produced, but P. nordicum was also found sporadically in other parts of the site. Product samples taken from products with visible mould growth were at both sites dominated by P. solitum, highlighting its importance for product quality. P. nordicum was found frequently in the long-time stored hams, indicating a food safety risk of these products. However, P. nordicum was rarely isolated from pinnekjøtt. Aspergillus spp. were isolated from both sites at all samplings; however, there were no Aspergillus isolated from products, and no sites were repeatedly tested positive for identical species, indicating that Aspergillus is not a part of the persistent mycobiota, but enters the site sporadically. In conclusion, the study showed that a stable mycobiota consisting of few Penicillium species dominated the products and production environments of pinnekjøtt. Copyright © 2018 Elsevier B.V. All rights reserved.

  4. Investigation of tt-bar in the full hadronic final state at CDF with a neural network approach

    International Nuclear Information System (INIS)

    Sidoti, A.; Azzi, P.; Busetto, G.; Castro, A.; Dusini, S.; Lazzizzera, I.; Wyss, J.L.

    2001-01-01

    In this work we present the results of a neural network (NN) approach to the measurement of the tt-bar production cross-section and top mass in the all-hadronic channel, analyzing data collected at the Collider Detector at Fermilab (CDF) experiment. We have used a hardware implementation of a feed forward neural network, TOTEM, the product of a collaboration of INFN (Istituto Nazionale Fisica Nucleare) - IRST (Istituto per la Ricerca Scientifica e Tecnologica) - University of Trento, Italy. Particular attention has been paid to the evaluation of the systematics specifically related to the NN approach. The results are consistent with those obtained at CDF by conventional data selection techniques

  5. Multi-proxy approach for palaeoclimate reconstruction using a loess-palaeosol sequence from Süttő , Hungary

    Science.gov (United States)

    Thiel, Christine; Königer, Paul; Ostertag-Henning, Christian; Scheeder, Georg; Novothny, Ágnes; Horváth, Erzsébet; Wacha, Lara; Techmer, Astrid; Frechen, Manfred

    2010-05-01

    The loess-palaeosol sequence at Süttő , Hungary contains a high-resolution terrestrial archive of palaeoenvironmental changes. The sequence is about 20 m thick and overlies travertine which was dated using Uranium-series to 235-314 ka (Sierralta et al., in press). Imbedded with the loess are two greyish stratified horizons, three brownish steppe-like soils and a pedocomplex composed of a reddish-brown palaeosol covered by a chernozem. Detailed dating studies were carried out (Novothny et al, 2009, Novothny et al., in press) revealing more or less continuous sedimentation from marine isotope stage (MIS) 6 to MIS 2. High-resolution grain size and magnetic susceptibility data exist (Novothny et al., in prep.) which allow for palaeoenvironmental reconstructions. In addition to those data sets we analysed the carbon and oxygen isotopic composition of bulk carbonate, carbonate nodules, and organic material in order to get further insight into palaeoprecipitation and palaeoclimatic conditions. To strengthen the interpretation based on isotopic data, we examined biomarkers derived from land plants (long-chain n-alkanes) for both loess and palaeosols to add information on the vegetation changes. We will discuss the new results in comparison with the published data sets and highlight inherent problems of the individual approaches. Novothny, A., Frechen, M., Horváth, E., Wacha, L., Rolf, C., in prep. High resolution grain size and magnetic susceptibility record of the last glacial cycles in the Süttő loess section, Hungary. Quaternary International. Novothny, A., Frechen, M., Horváth, E., Krbetschek, M., Tsukamoto, S., in press. Infrared stimulated luminescence and radiofluorescence dating of aeolian sediments from Hungary. Quaternary Geochronology, doi:10.1016/j.quageo.2009.05.002. Novothny, A., Frechen, M., Horváth, E., Bradák, B., Oches, E. A., McCoy, W. D., Stevens, T., 2009a. Luminescence and amino acid racemisation chronology of the loess-paleosol sequence

  6. ABB Oy Motors and Generators -yksikön energiansyöttöjen erotus- ja lukitusohjeet

    OpenAIRE

    Chi, Henri

    2017-01-01

    Tämä insinöörityö toteutettiin Quant Finland Oy:lle, joka vastaa Helsingin Pitäjänmäen ABB Motors and Generators -tehtaan kunnossapidosta. Insinöörityön tavoitteena oli luoda energiansyöttöjen lukitus- ja erotusohjeet tehtaan koneistoille, laitteille ja järjestelmille. Tehtaalla on isoja koneita ja laitteita, jonka erotus- ja lukitustoimenpiteitä kaikki eivät osaa. Näin ollen on haluttu mahdollistaa turvallinen työskentely tarjoamalla selkeät erotus- ja lukitusohjeet. ABB Motors and Gene...

  7. CP violating asymmetries of b quarks and leptons in e+e-→tt-bar and supersymmetry

    International Nuclear Information System (INIS)

    Christova, E.

    1998-09-01

    The distributions of the single decay b-quarks and leptons from e + e - →tt-bar assuming CP violation are reviewed. Different asymmetries, sensitive independently to CP violation in the production and in the decay, and sensitive to the real and imaginary parts of d γ and d Z are defined. The analytic expressions are general and independent on the model of CP violation. In most of them all phase space integrations are fulfilled analytically. Numerical results in the MSSM with complex couplings are presented. (author)

  8. Comprehensive sulfation model verified for T-T sorbent clusters during flue gas desulfurization at moderate temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Yuran Li; Haiying Qi; Changfu You; Lizhai Yang [Tsinghua University, Beijing (China). Key Laboratory for Thermal Science and Power Engineering of Ministry of Education

    2010-08-15

    An empirical sulfation model for T-T sorbent clusters was developed based on amassed experimental results under moderate temperatures (300-800{sup o}C). In the model, the reaction rate is a function of clusters mass, SO{sub 2} concentration, CO{sub 2} concentration, calcium conversion and temperature. The smaller pore volume partly results in a lower reaction rate at lower temperatures. The exponent on SO{sub 2} concentration is 0.88 in the rapid reaction stage and then decreases gradually as reaction progresses. The exponent on the fraction of the unreacted calcium is 1/3 in the first stage and then increases significantly in the second stage. The CO{sub 2} concentration has a negative influence on SO{sub 2} removal, especially for the temperature range of 400-650{sup o}C, which should be avoided to achieve a high effective calcium conversion. The sulfation model has been verified for the T-T sorbent clusters and has also been applied to CaO particles. Over extensive reaction conditions, the predictions agree well with experimental data. 17 refs., 10 figs., 2 tabs.

  9. Discriminating between Higgs Boson models using e+e- → tt-bar h and Zh at the NLC

    International Nuclear Information System (INIS)

    Gunion, J. F.; He, X. G.

    1997-01-01

    In extensions of the Standard Model (SM) there are multiple neutral Higgs bosons. Their masses and couplings are often dependent upon many parameters; CP-violating mixing of CP-even with CP-odd neutral Higgs fields is generally possible. It is demonstrated that the process e + e - → tt-bar h at the NLC provides a powerful tool for extracting the tt-bar (Yukawa) couplings of the h. In combination with the e + e - → Zh process, an accurate determination of the ZZ coupling of the H is also possible. The resulting ability to distinguish different models of the Higgs sector is illustrated by detailed studies for two-Higgs-doublet models, for which the masses and couplings of the three neutral Higgs bosons are all free parameters. It is concluded that it is very possible that the SM is not correct. In this case, and if there is a weakly-coupled Higgs sector, there will certainly be Higgs bosons that do not have SM-like couplings. 3 refs., 3 figs

  10. Top-quark mass measurement in the tt-bar-dilepton channel using the full CDF Run II data set

    International Nuclear Information System (INIS)

    Budagov, J.; Glagolev, V.; Suslov, I.; Velev, G.

    2014-01-01

    We present a measurement of the top-quark mass with tt-bar-dilepton events using the full CDF Run II data set, which corresponds to an integrated luminosity of 9.1 fb -1 collected from √s = 1.96 TeV pp-bar collisions at the Fermilab Tevatron. A sample of 520 events is obtained after all selection requirements. The top-quark mass is estimated by a fit of the distribution of some variable to a sum of signal and background contributions. This variable is defined using special approach to reduce the systematic error due to the jet energy scale uncertainty. Templates are built from simulated tt-bar and background events, and parameterized in order to provide probability distribution functions. A likelihood fit of the data returns the top-quark mass of (170.80∓1.83 (stat.)∓2.69 (syst.)) GeV/c 2 (or (170.80∓3.25) GeV/c 2 ).

  11. Hydrides of Alkaline Earth–Tetrel (AeTt) Zintl Phases: Covalent Tt–H Bonds from Silicon to Tin

    Energy Technology Data Exchange (ETDEWEB)

    Auer, Henry; Guehne, Robin; Bertmer, Marko; Weber, Sebastian; Wenderoth, Patrick; Hansen, Thomas Christian; Haase, Jürgen; Kohlmann, Holger (Leipzig); (Saarland-MED); (ILL)

    2017-01-18

    Zintl phases form hydrides either by incorporating hydride anions (interstitial hydrides) or by covalent bonding of H to the polyanion (polyanionic hydrides), which yields a variety of different compositions and bonding situations. Hydrides (deuterides) of SrGe, BaSi, and BaSn were prepared by hydrogenation (deuteration) of the CrB-type Zintl phases AeTt and characterized by laboratory X-ray, synchrotron, and neutron diffraction, NMR spectroscopy, and quantum-chemical calculations. SrGeD4/3–x and BaSnD4/3–x show condensed boatlike six-membered rings of Tt atoms, formed by joining three of the zigzag chains contained in the Zintl phase. These new polyanionic motifs are terminated by covalently bound H atoms with d(Ge–D) = 1.521(9) Å and d(Sn–D) = 1.858(8) Å. Additional hydride anions are located in Ae4 tetrahedra; thus, the features of both interstitial hydrides and polyanionic hydrides are represented. BaSiD2–x retains the zigzag Si chain as in the parent Zintl phase, but in the hydride (deuteride), it is terminated by H (D) atoms, thus forming a linear (SiD) chain with d(Si–D) = 1.641(5) Å.

  12. rs11613352 polymorphism (TT genotype) associates with a decrease of triglycerides and an increase of HDL in familial hypercholesterolemia patients.

    Science.gov (United States)

    Aledo, Rosa; Padró, Teresa; Mata, Pedro; Alonso, Rodrigo; Badimon, Lina

    2015-04-01

    Recent genome-wide association studies have identified a locus on chromosome 12q13.3 associated with plasma levels of triglyceride and high-density lipoprotein cholesterol, with rs11613352 being the lead single nucleotide polymorphism in this genome-wide association study locus. The aim of the study is to investigate the involvement of rs11613352 in a population with high cardiovascular risk due to familial hypercholesterolemia. The single nucleotide polymorphism was genotyped by Taqman(®) assay in a cohort of 601 unrelated familial hypercholesterolemia patients and its association with plasma triglyceride and high-density lipoprotein cholesterol levels was analyzed by multivariate methods based on linear regression. Minimal allele frequency was 0.17 and genotype frequencies were 0.69, 0.27, and 0.04 for CC, CT, and TT genotypes, respectively. The polymorphism is associated in a recessive manner (TT genotype) with a decrease in triglyceride levels (P=.002) and with an increase in high-density lipoprotein cholesterol levels (P=.021) after adjusting by age and sex. The polymorphism rs11613352 may contribute to modulate the cardiovascular risk by modifying plasma lipid levels in familial hypercholesterolemia patients. Copyright © 2014 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

  13. BRCA Genetic Screening in Middle Eastern and North African: Mutational Spectrum and Founder BRCA1 Mutation (c.798_799delTT in North African

    Directory of Open Access Journals (Sweden)

    Abdelilah Laraqui

    2015-01-01

    Full Text Available Background. The contribution of BRCA1 mutations to both hereditary and sporadic breast and ovarian cancer (HBOC has not yet been thoroughly investigated in MENA. Methods. To establish the knowledge about BRCA1 mutations and their correlation with the clinical aspect in diagnosed cases of HBOC in MENA populations. A systematic review of studies examining BRCA1 in BC women in Cyprus, Jordan, Egypt, Lebanon, Morocco, Algeria, and Tunisia was conducted. Results. Thirteen relevant references were identified, including ten studies which performed DNA sequencing of all BRCA1 exons. For the latter, 31 mutations were detected in 57 of the 547 patients ascertained. Familial history of BC was present in 388 (71% patients, of whom 50 were mutation carriers. c.798_799delTT was identified in 11 North African families, accounting for 22% of total identified BRCA1 mutations, suggesting a founder allele. A broad spectrum of other mutations including c.68_69delAG, c.181T>G, c.5095C>T, and c.5266dupC, as well as sequence of unclassified variants and polymorphisms, was also detected. Conclusion. The knowledge of genetic structure of BRCA1 in MENA should contribute to the assessment of the necessity of preventive programs for mutation carriers and clinical management. The high prevalence of BC and the presence of frequent mutations of the BRCA1 gene emphasize the need for improving screening programs and individual testing/counseling.

  14. Meningococcal groups C and Y and haemophilus B tetanus toxoid conjugate vaccine (HibMenCY-TT; MenHibrix(®)): a review.

    Science.gov (United States)

    Perry, Caroline M

    2013-05-01

    The meningococcal groups C and Y and Haemophilus b (Hib) tetanus toxoid conjugate vaccine (HibMenCY-TT) contains Neisseria meningitidis serogroup C and Y capsular polysaccharide antigens, and Hib capsular polysaccharide [polyribosyl-ribitol-phosphate (PRP)]. The HibMenCY-TT vaccine is available in the USA for use as active immunization to prevent invasive disease caused by N. meningitidis serogroups C (MenC) and Y (MenY), and Hib in children 6 weeks-18 months of age. HibMenCY-TT is the first meningococcal vaccine available for use in the USA that can be administered to infants as young as 6 weeks of age. In a randomized, controlled, phase III clinical trial, the HibMenCY-TT vaccine, administered to infants at 2, 4, 6 and 12-15 months of age, was immunogenic against MenC and MenY, and met the prespecified criteria for immunogenicity. Anti-PRP antibodies, which have been shown to correlate with protection against Hib invasive disease, were also induced in the infants who received the HibMenCY-TT vaccine, with induced levels of this antibody noninferior to those occurring in the control group of infants who received a Hib tetanus toxoid conjugate vaccine at 2, 4, and 6 months and a single dose of Hib conjugated to N. meningitidis outer membrane protein at 12-15 months. In several randomized, controlled clinical trials, HibMenCY-TT was coadministered with vaccines that are routinely administered to infants and toddlers in the USA. These vaccines included: diphtheria and tetanus toxoids and acellular pertussis adsorbed, hepatitis B (recombinant) and inactivated poliovirus vaccine combined; 7-valent Streptococcus pneumoniae polysaccharide conjugate vaccine; measles, mumps and rubella vaccine; and varicella vaccine. Coadministration of these vaccines did not interfere with the immunogenicity of the HibMenCY-TT vaccine. Similarly, immune responses to the coadministered vaccines were not affected by the HibMenCY-TT vaccine. The tolerability profile of the HibMenCY-TT

  15. Transformation with TT8 and HB12 RNAi Constructs in Model Forage (Medicago sativa, Alfalfa) Affects Carbohydrate Structure and Metabolic Characteristics in Ruminant Livestock Systems.

    Science.gov (United States)

    Li, Xinxin; Zhang, Yonggen; Hannoufa, Abdelali; Yu, Peiqiang

    2015-11-04

    Lignin, a phenylpropanoid polymer present in secondary cell walls, has a negative impact on feed digestibility. TT8 and HB12 genes were shown to have low expression levels in low-lignin tissues of alfalfa, but to date, there has been no study on the effect of down-regulation of these two genes in alfalfa on nutrient chemical profiles and availability in ruminant livestock systems. The objectives of this study were to investigate the effect of transformation of alfalfa with TT8 and HB12 RNAi constructs on carbohydrate (CHO) structure and CHO nutritive value in ruminant livestock systems. The results showed that transformation with TT8 and HB12 RNAi constructs reduced rumen, rapidly degraded CHO fractions (RDCA4, P = 0.06; RDCB1, P alfalfa with TT8 and HB12 RNAi constructs induced molecular structure changes. Different CHO functional groups had different sensitivities and different responses to the transformation. The CHO molecular structure changes induced by the transformation were associated with predicted CHO availability. Compared with HB12 RNAi, transformation with TT8 RNAi could improve forage quality by increasing the availability of both NDF and DM. Further study is needed on the relationship between the transformation-induced structure changes at a molecular level and nutrient utilization in ruminant livestock systems when lignification is much higher.

  16. [Population health surveillance of the general population living near Turin (Northern Italy) incinerator (SPoTT): methodology of the study].

    Science.gov (United States)

    Bena, Antonella; Chiusolo, Monica; Orengia, Manuela; Cadum, Ennio; Farina, Elena; Musmeci, Loredana; Procopio, Enrico; Salamina, Giuseppe

    2016-01-01

    Si intende qui descrivere il sistema di sorveglianza sugli effetti sulla salute (SpoTT) dell'inquinamento ambientale nelle aree circostanti l'inceneritore di Torino. SPoTT ha 3 linee di attività: 1. monitoraggio epidemiologico degli effetti a breve termine attraverso analisi temporali e misura della correlazione tra livelli giornalieri di emissioni dell'impianto e andamento degli eventi individuati dagli archivi dei dimessi (SDO), di pronto soccorso e di mortalità; sono coinvolti coloro che nel 2013-2018 risiedevano nell'area di ricaduta delle emissioni; 2. sorveglianza epidemiologica degli effetti a lungo termine, stimando tassi standardizzati di mortalità e morbosità; a ogni soggetto è attribuito il valore stimato di esposizione cumulato nel tempo caratteristico della residenza anagrafica; le informazioni sulla salute sono reperite dagli archivi SDO, di mortalità e dai certificati di assistenza al parto; sono studiati due decenni pre-post l'avvio dell'impianto: 2003-2012 e 2013-2022; 3. monitoraggio biologico con misurazione pre-post di metalli, PCDD/F, PCB, OH-IPA; sono coinvolti 196 residenti esposti e 196 di controllo di 35-69 anni, campionati a caso dalle anagrafi comunali; sono effettuate misure di funzionalità endocrina e respiratoria, pressione arteriosa, rischio cardiovascolare; l'esposizione cumulativa sarà stimata per ciascuna persona campionata integrando l'indirizzo di residenza, il tempo di permanenza in ciascun indirizzo e i dati ricavati dai modelli di ricaduta; sarà costituita una biobanca per future indagini di laboratorio; sono coinvolti anche 20 allevatori e i lavoratori dell'impianto. Una quarta linea di attività, non descritta in questo articolo, riguarda il monitoraggio della salute dei lavoratori addetti all'impianto. SPoTT è il primo studio in Italia su inceneritori e salute che adotta un disegno di studio longitudinale di adeguata potenza sia per i residenti sia per i lavoratori. I primi risultati sono attesi nel corso del 2016.

  17. Measurements of top quark spin observables in tt̄ events using dilepton final states in √s=8 TeV pp collisions with the ATLAS detector

    Energy Technology Data Exchange (ETDEWEB)

    Aaboud, M. [Faculté des Sciences, Université Mohamed Premier and LPTPM, Oujda (Morocco); Aad, G. [CPPM, Aix-Marseille Université and CNRS/IN2P3, Marseille (France); Abbott, B. [Homer L. Dodge Department of Physics and Astronomy, University of Oklahoma, Norman OK, United States of America (United States); Abdallah, J. [Department of Physics, The University of Texas at Arlington, Arlington TX, United States of America (United States); Collaboration: The ATLAS collaboration; and others

    2017-03-22

    Measurements of top quark spin observables in tt̄ events are presented based on 20.2 fb{sup −1} of √s=8 TeV proton-proton collisions recorded with the ATLAS detector at the LHC. The analysis is performed in the dilepton final state, characterised by the presence of two isolated leptons (electrons or muons). There are 15 observables, each sensitive to a different coefficient of the spin density matrix of tt̄ production, which are measured independently. Ten of these observables are measured for the first time. All of them are corrected for detector resolution and acceptance effects back to the parton and stable-particle levels. The measured values of the observables at parton level are compared to Standard Model predictions at next-to-leading order in QCD. The corrected distributions at stable-particle level are presented and the means of the distributions are compared to Monte Carlo predictions. No significant deviation from the Standard Model is observed for any observable.

  18. Yhdessä kierrättämään : Raaseporin kaupungin työllisyysosaston työpajatoiminnan kehittämishanke

    OpenAIRE

    Westerholm, Leena

    2016-01-01

    Aktiivisen sosiaali- ja työvoimapolitiikan myötä ovat kuntien vastuut pitkäaikaistyöttömien palveluista lisääntyneet. Työllisyyskysymykset ovat muodostuneet luontevaksi osaksi sosiaalityötä. Kuntien lakisääteiset tehtävät sisältävät ikääntyvien työllistämisvelvoitteen, työmarkkinatuen rahoitusvastuun, työttömien terveyden edistämisen ja kuntouttavan työtoiminnan järjestämisen. Sosiaalihuoltolain alainen kuntouttava työtoiminta on kunnan järjestämää toimintaa, joka tähtää pitkäaikaistyöttömän ...

  19. Determining the CP nature of spin-0 mediators in associated production of dark matter and tt̄ pairs

    Energy Technology Data Exchange (ETDEWEB)

    Haisch, Ulrich [Rudolf Peierls Centre for Theoretical Physics, University of Oxford,OX1 3NP Oxford (United Kingdom); CERN, Theoretical Physics Department,CH-1211 Geneva 23 (Switzerland); Pani, Priscilla [Department of Physics, Stockholm University,AlbaNova University Center, 106 91 Stockholm (Sweden); CERN, Experimental Physics Department,CH-1211 Geneva 23 (Switzerland); Polesello, Giacomo [INFN, Sezione di Pavia,Via Bassi 6, 27100 Pavia (Italy); CERN, Experimental Physics Department,CH-1211 Geneva 23 (Switzerland)

    2017-02-27

    In the framework of spin-0 s-channel simplified models, we explore the possibility of assessing the structure of dark matter interactions through the associate production of dark matter and tt̄ pairs. To this purpose, final states with two leptons are considered and the kinematic properties of the dilepton system is studied. We develop a realistic analysis strategy and provide a detailed evaluation of the achievable sensitivity for the dark matter signal assuming integrated luminosities of 300 fb{sup −1} and 3 ab{sup −1} at the 14 TeV LHC. Furthermore, upper limits on the mediator masses for which the two different CP hypotheses can be distinguished are derived. The obtained limits on the signal strengths are finally translated into constraints on the parameter space of two spin-0 simplified models including a scenario with an extended Higgs sector.

  20. Corrosion in PWR steam generator tubes made of alloy 600TT: overview of operating experience, NDE and safety issues

    International Nuclear Information System (INIS)

    Curieres, I. de; Sollier, T.; Delaval, C.

    2015-01-01

    About 60 PWR plants worldwide are operating with steam generator tubes made of alloy 600TT, among which 27 are located in France. This alloy is susceptible to corrosion, both on the primary and secondary side in every fleet, though with different kinetics or extent. It is noteworthy that many of the primary side corrosion issues can be clearly explained by design or operating conditions. However, studies show that all the secondary side issues are much hardly explained by simple considerations. This paper will give an overview of the international operating experience of this alloy and indicate the associated controllability and safety-related issues. An emphasis will be put on the manufacturing, chemistry and specificities of the different fleets. The French situation will be reviewed in this frame. (authors)

  1. Next-generation sequencing-based transcriptome analysis of Helicoverpa armigera Larvae immune-primed with Photorhabdus luminescens TT01.

    Directory of Open Access Journals (Sweden)

    Zengyang Zhao

    Full Text Available Although invertebrates are incapable of adaptive immunity, immunal reactions which are functionally similar to the adaptive immunity of vertebrates have been described in many studies of invertebrates including insects. The phenomenon was termed immune priming. In order to understand the molecular mechanism of immune priming, we employed Illumina/Solexa platform to investigate the transcriptional changes of the hemocytes and fat body of Helicoverpa armigera larvae immune-primed with the pathogenic bacteria Photorhabdus luminescens TT01. A total of 43.6 and 65.1 million clean reads with 4.4 and 6.5 gigabase sequence data were obtained from the TT01 (the immune-primed and PBS (non-primed cDNA libraries and assembled into 35,707 all-unigenes (non-redundant transcripts, which has a length varied from 201 to 16,947 bp and a N50 length of 1,997 bp. For 35,707 all-unigenes, 20,438 were functionally annotated and 2,494 were differentially expressed after immune priming. The differentially expressed genes (DEGs are mainly related to immunity, detoxification, development and metabolism of the host insect. Analysis on the annotated immune related DEGs supported a hypothesis that we proposed previously: the immune priming phenomenon observed in H. armigera larvae was achieved by regulation of key innate immune elements. The transcriptome profiling data sets (especially the sequences of 1,022 unannotated DEGs and the clues (such as those on immune-related signal and regulatory pathways obtained from this study will facilitate immune-related novel gene discovery and provide valuable information for further exploring the molecular mechanism of immune priming of invertebrates. All these will increase our understanding of invertebrate immunity which may provide new approaches to control insect pests or prevent epidemic of infectious diseases in economic invertebrates in the future.

  2. Associated top production (ttV, tV) in ATLAS and CMS

    CERN Document Server

    Sánchez Cruz, Sergio

    2018-01-01

    A set of measurements of top quark pair and single top quark production in association with standard model (SM) bosons performed by the CMS and ATLAS Collaborations is presented. The consistency of these results among themselves and with the SM prediction is discussed. The latest results on four top quark production are also shown.

  3. Time to threshold (TT), a safety parameter for heating by diagnostic ultrasound

    NARCIS (Netherlands)

    Lubbers, J.; Hekkenberg, R.T.; Bezemer, R.A.

    2003-01-01

    Activities in the standardisation of medical ultrasonic imaging and monitoring devices have been undertaken to ensure the safe application and to provide the user with tools to perform risk-to-benefit analysis. Internationally, agreement has not been reached to implement a system based on a physical

  4. Time to threshold (TT), a safety parameter for heating by diagnostic ultrasound

    NARCIS (Netherlands)

    Lubbers, J; Hekkenberg, RT; Bezemer, RA

    Activities in the standardisation of medical ultrasonic imaging and monitoring devices have been undertaken to ensure the safe application and to provide the user with tools to perform risk-to-benefit analysis. Internationally, agreement has not been reached to implement a system based on a physical

  5. An evaluation of the statistical variability in thermal expansion properties of steam generator tubesheet (SA-508) and tubing (Alloy-600TT)

    International Nuclear Information System (INIS)

    Riccardella, P.C.; Staples, J.F.; Kandra, J.T.

    2009-01-01

    Inspections of steam generator tubing are performed in U.S. PWRs as part of the Steam Generator Management Program. Westinghouse has recently completed a technical justification demonstrating that in steam generators with thermally treated Ni-Cr Alloy (Alloy 600TT) tubes that are hydraulically expanded into low alloy steel (SA-508) tubesheets, flaws in the region of the tubes below a certain distance from the top of the tubesheet, denoted H * , will not result in reactor coolant pressure boundary breach nor unacceptable primary-to-secondary leakage. This is because, even if a flaw in this region were to result in complete tube sever, if the length of undegraded tube in the tubesheet exceeds H*, neither operating nor accident loadings create sufficient pull-out forces to overcome the frictional forces between the tube and tubesheet. One key component of this technical justification is the differential thermal expansion between the tube and tubesheet, since a significant portion of the pullout strength of the hydraulically expanded tube-to-tubesheet joint is due to mechanical interference resulting from the larger expansion of the tubing relative to the tubesheet at a given temperature. To address this phenomenon, a detailed statistical evaluation of coefficient of thermal expansion (CTE) data for the tubesheet material (SA-508) and the tube material (thermally treated Alloy-600) was performed. Data used in the evaluation included existing test results obtained from a number of sources as well as extensive new laboratory data developed specifically for this purpose. The evaluation resulted in recommended statistical distributions of this property for the two materials including their means and probabilistic variability. In addition, it was determined that the CTE values reported in the ASME Code (Section II) represent reasonably conservative mean values for both the tubesheet and tubing material. (author)

  6. Top quark production at the LHC (single top and tt-bar cross sections)

    International Nuclear Information System (INIS)

    Lange, J.

    2014-01-01

    With the large number of top quarks produced at the LHC, top quark physics enters an era of precision and properties measurements. This article reviews the recent advances in top quark cross section measurements performed by ATLAS and CMS using data recorded in 2011 with integrated luminosities up to 5 fb -1 . They include precision inclusive cross sections, the establishment of challenging channels, first differential cross section measurements and single top production. An overall good agreement with Standard Model predictions is observed

  7. [Valitsusliidus olevad Reformierakond ning Isamaa ja Res Publica Liit on kavandatava koolireformi suhtes eri meelt] / Mailis Reps, Tiiu Kuurme, Karin Kütt

    Index Scriptorium Estoniae

    Reps, Mailis, 1975-

    2010-01-01

    Reformierakonna ettepaneku kohta jätta omavalitsustele õiguse otsustada, kas gümnaasium ja põhikool lahutatakse või jätkatakse ühendkooliga avaldavad arvamust riigikogu liige Mailis Reps, Tallinna Ülikooli dotsent Tiiu Kuurme ja Rannu keskkooli direktor Karin Kütt

  8. Analysis of Atorvastatin in Commercial Solid Drugs using the TT-PIGE Technique

    International Nuclear Information System (INIS)

    Younes, G; Zahraman, K; Nsouli, B; Bejjani, A; Mahmoud, R; El-Yazbi, F

    2008-01-01

    The quantification of the active ingredient (Al) in drugs is a crucial and important step in the drug quality control process. This is usually performed by using wet chemical techniques like LC-MS, UV spectrophotometry and other appropriate organic analytical methods. In the case of an active ingredient contains specific heteroatoms (F, S, Cl), elemental IBA techniques can be explored for molecular quantification. IBA techniques permit the analysis of the sample under solid form, without any laborious sample preparations. This is an advantage when the number of sample is relatively large. In this work, we demonstrate the ability of the Thick Target PIGE technique for rapid and accurate quantification of low concentration AtorvastatinTM in three commercial anti-hyperlipidemic drugs (Lipitor, Liponorm and Storvas). (author)

  9. Analysis of Atorvastatin in Commercial Solid Drugs using the TT-PIGE Technique

    Energy Technology Data Exchange (ETDEWEB)

    Younes, G [Beirut Arab University, Faculty of Science, Chemistry Department Beirut (Lebanon); Zahraman, K; Nsouli, B; Bejjani, A [Lebanese Atomic Energy Commission, National Council for Scientific Research, Beirut (Lebanon); Mahmoud, R; El-Yazbi, F [Beirut Arab University, Faculty of Pharmacy, Department of Pharmaceutical and Analytical Chemistry, Beirut (Lebanon)

    2008-07-01

    The quantification of the active ingredient (Al) in drugs is a crucial and important step in the drug quality control process. This is usually performed by using wet chemical techniques like LC-MS, UV spectrophotometry and other appropriate organic analytical methods. In the case of an active ingredient contains specific heteroatoms (F, S, Cl), elemental IBA techniques can be explored for molecular quantification. IBA techniques permit the analysis of the sample under solid form, without any laborious sample preparations. This is an advantage when the number of sample is relatively large. In this work, we demonstrate the ability of the Thick Target PIGE technique for rapid and accurate quantification of low concentration AtorvastatinTM in three commercial anti-hyperlipidemic drugs (Lipitor, Liponorm and Storvas). (author)

  10. Combined caffeine and carbohydrate ingestion: effects on nocturnal sleep and exercise performance in athletes.

    Science.gov (United States)

    Miller, Ben; O'Connor, Helen; Orr, Rhonda; Ruell, Patricia; Cheng, Hoi Lun; Chow, Chin Moi

    2014-12-01

    In athletes, caffeine use is common although its effects on sleep have not been widely studied. This randomised, double-blind, placebo-controlled crossover trial investigated the effects of late-afternoon caffeine and carbohydrate-electrolyte (CEB) co-ingestion on cycling performance and nocturnal sleep. Six male cyclists/triathletes (age 27.5 ± 6.9 years) completed an afternoon training session (TS; cycling 80 min; 65% VO₂max) followed by a 5 kJ kg(-1) cycling time trial (TT). Caffeine (split dose 2 × 3 mg kg(-1)) or placebo was administered 1 h prior and 40 min into the TS. A 7.4% CEB (3 ml kg(-1) every 15 min) was administered during the TS, followed 30 min after by a standardised evening meal. Participants retired at their usual bedtime and indices of sleep duration and quality were monitored via polysomnography. mean ± SD. All participants performed better in the caffeine TT (caffeine 19.7 ± 3.3; placebo 20.5 ± 3.5 min; p = 0.006), while ratings of perceived exertion (caffeine 12.0 ± 0.6; placebo 12.9 ± 0.7; p = 0.004) and heart rate (caffeine 175 ± 6; placebo 167 ± 11 bpm; p = 0.085) were lower in the caffeine TS. Caffeine intake induced significant disruptions to a number of sleep indices including increased sleep onset latency (caffeine 51.1 ± 34.7; placebo 10.2 ± 4.2 min; p = 0.028) and decreased sleep efficiency (caffeine 76.1 ± 19.6; placebo 91.5 ± 4.2%; p = 0.028), rapid eye movement sleep (caffeine 62.1 ± 19.6; placebo 85.8 ± 24.7 min; p = 0.028) and total sleep time (caffeine 391 ± 97; placebo 464 ± 49 min; p = 0.028). This study supports a performance-enhancing effect of caffeine, although athletes (especially those using caffeine for late-afternoon/evening training and competition) should consider its deleterious effects on sleep.

  11. Summary of the OECD/NRC Boiling Water Reactor Turbine Trip Benchmark - Fifth Workshop (BWR-TT5)

    International Nuclear Information System (INIS)

    2003-01-01

    The reference problem chosen for simulation in a BWR is a Turbine Trip transient, which begins with a sudden Turbine Stop Valve (TSV) closure. The pressure oscillation generated in the main steam piping propagates with relatively little attenuation into the reactor core. The induced core pressure oscillation results in dramatic changes of the core void distribution and fluid flow. The magnitude of the neutron flux transient taking place in the BWR core is strongly affected by the initial rate of pressure rise caused by pressure oscillation and has a strong spatial variation. The correct simulation of the power response to the pressure pulse and subsequent void collapse requires a 3-D core modeling supplemented by 1-D simulation of the remainder of the reactor coolant system. A BWR TT benchmark exercise, based on a well-defined problem with complete set of input specifications and reference experimental data, has been proposed for qualification of the coupled 3-D neutron kinetics/thermal-hydraulic system transient codes. Since this kind of transient is a dynamically complex event with reactor variables changing very rapidly, it constitutes a good benchmark problem to test the coupled codes on both levels: neutronics/thermal-hydraulic coupling and core/plant system coupling. Subsequently, the objectives of the proposed benchmark are: comprehensive feedback testing and examination of the capability of coupled codes to analyze complex transients with coupled core/plant interactions by comparison with actual experimental data. The benchmark consists of three separate exercises: Exercise 1 - Power vs. Time Plant System Simulation with Fixed Axial Power Profile Table (Obtained from Experimental Data). Exercise 2 - Coupled 3-D Kinetics/Core Thermal-Hydraulic BC Model and/or 1-D Kinetics Plant System Simulation. Exercise 3 - Best-Estimate Coupled 3-D Core/Thermal-Hydraulic System Modeling. The purpose of this fifth workshop was to discuss the results from Phase III (best

  12. Performance effects of acute β-alanine induced paresthesia in competitive cyclists.

    Science.gov (United States)

    Bellinger, Phillip M; Minahan, Clare L

    2016-01-01

    β-alanine is a common ingredient in supplements consumed by athletes. Indeed, athletes may believe that the β-alanine induced paresthesia, experienced shortly after ingestion, is associated with its ergogenic effect despite no scientific mechanism supporting this notion. The present study examined changes in cycling performance under conditions of β-alanine induced paresthesia. Eight competitive cyclists (VO2max = 61.8 ± 4.2 mL·kg·min(-1)) performed three practices, one baseline and four experimental trials. The experimental trials comprised a 1-km cycling time trial under four conditions with varying information (i.e., athlete informed β-alanine or placebo) and supplement content (athlete received β-alanine or placebo) delivered to the cyclist: informed β-alanine/received β-alanine, informed placebo/received β-alanine, informed β-alanine/received placebo and informed placebo/received placebo. Questionnaires were undertaken exploring the cyclists' experience of the effects of the experimental conditions. A possibly likely increase in mean power was associated with conditions in which β-alanine was administered (±95% CL: 2.2% ± 4.0%), but these results were inconclusive for performance enhancement (p = 0.32, effect size = 0.18, smallest worthwhile change = 56% beneficial). A possibly harmful effect was observed when cyclists were correctly informed that they had ingested a placebo (-1.0% ± 1.9%). Questionnaire data suggested that β-alanine ingestion resulted in evident sensory side effects and six cyclists reported placebo effects. Acute ingestion of β-alanine is not associated with improved 1-km TT performance in competitive cyclists. These findings are in contrast to the athlete's "belief" as cyclists reported improved energy and the ability to sustain a higher power output under conditions of β-alanine induced paresthesia.

  13. TT Mutant Homozygote of Is a Key Factor for Increasing Basal Metabolic Rate and Resting Metabolic Rate in Korean Elementary School Children

    Directory of Open Access Journals (Sweden)

    Jung Ran Choi

    2013-12-01

    Full Text Available We investigated the contribution of genetic variations of KLF5 to basal metabolic rate (BMR and resting metabolic rate (RMR and the inhibition of obesity in Korean children. A variation of KLF5 (rs3782933 was genotyped in 62 Korean children. Using multiple linear regression analysis, we developed a model to predict BMR in children. We divided them into several groups; normal versus overweight by body mass index (BMI and low BMR versus high BMR by BMR. There were no differences in the distributions of alleles and genotypes between each group. The genetic variation of KLF5 gene showed a significant correlation with several clinical factors, such as BMR, muscle, low-density lipoprotein cholesterol, and insulin. Children with the TT had significantly higher BMR than those with CC (p = 0.030. The highest muscle was observed in the children with TT compared with CC (p = 0.032. The insulin and C-peptide values were higher in children with TT than those with CC (p= 0.029 vs. p = 0.004, respectively. In linear regression analysis, BMI and muscle mass were correlated with BMR, whereas insulin and C-peptide were not associated with BMR. In the high-BMR group, we observed that higher muscle, fat mass, and C-peptide affect the increase of BMR in children with TT (p < 0.001, p < 0.001, and p = 0.018, respectively, while Rohrer's index could explain the usual decrease in BMR (adjust r2 = 1.000, p < 0.001, respectively. We identified a novel association between TT of KLF5 rs3782933 and BMR in Korean children. We could make better use of the variation within KLF5 in a future clinical intervention study of obesity.

  14. Human Infant Memory B Cell and CD4+ T Cell Responses to HibMenCY-TT Glyco-Conjugate Vaccine.

    Directory of Open Access Journals (Sweden)

    Angela Fuery

    Full Text Available Carrier-specific T cell and polysaccharide-specific B cell memory responses are not well characterised in infants following glyco-conjugate vaccination. We aimed to determine if the number of Meningococcal (Men C- and Y- specific memory B cells and; number and quality of Tetanus Toxoid (TT carrier-specific memory CD4+ T cells are associated with polysaccharide-specific IgG post HibMenCY-TT vaccination. Healthy infants received HibMenCY-TT vaccine at 2, 4 and 6 months with a booster at 12 months. Peripheral blood mononuclear cells were isolated and polysaccharide-specific memory B cells enumerated using ELISpot. TT-specific memory CD4+ T cells were detected and phenotyped based on CD154 expression and intracellular TNF-α, IL-2 and IFN-γ expression following stimulation. Functional polysaccharide-specific IgG titres were measured using the serum bactericidal activity (SBA assay. Polysaccharide-specific Men C- but not Men Y- specific memory B cell frequencies pre-boost (12 months were significantly associated with post-boost (13 months SBA titres. Regression analysis showed no association between memory B cell frequencies post-priming (at 6 or 7 months and SBA at 12 months or 13 months. TT-specific CD4+ T cells were detected at frequencies between 0.001 and 0.112 as a percentage of CD3+ T cells, but their numbers were not associated with SBA titres. There were significant negative associations between SBA titres at M13 and cytokine expression at M7 and M12.Induction of persistent polysaccharide-specific memory B cells prior to boosting is an important determinant of secondary IgG responses in infants. However, polysaccharide-specific functional IgG responses appear to be independent of the number and quality of circulating carrier-specific CD4+ T cells after priming.

  15. Structural and thermodynamic similarities of phases in the Li-Tt (Tt = Si, Ge) systems: redetermination of the lithium-rich side of the Li-Ge phase diagram and crystal structures of Li17Si4.0-xGex for x = 2.3, 3.1, 3.5, and 4 as well as Li4.1Ge.

    Science.gov (United States)

    Zeilinger, Michael; Fässler, Thomas F

    2014-10-28

    A reinvestigation of the lithium-rich section of the Li-Ge phase diagram reveals the existence of two new phases, Li17Ge4 and Li4.10Ge (Li16.38Ge4). Their structures are determined by X-ray diffraction experiments of large single crystals obtained from equilibrated melts with compositions Li95Ge5 and Li85Ge15. Excess melt is subsequently removed through isothermal centrifugation at 400 °C and 530 °C, respectively. Li17Ge4 crystallizes in the space group F4[combining macron]3m (a = 18.8521(3) Å, V = 6700.1(2) Å(3), Z = 20, T = 298 K) and Li4.10Ge (Li16.38Ge4) in Cmcm (a = 4.5511(2) Å, b = 22.0862(7) Å, c = 13.2751(4) Å, V = 1334.37(8) Å(3), Z = 16, T = 123 K). Both phases are isotypic with their Si counterparts and are further representative of the Li17Pb4 and Li4.11Si structure types. Additionally, the solid solutions Li17Si4-xGex follows Vegard's law. A comparison of the GeLin coordination polyhedra shows that isolated Ge atoms are 13- and 14-coordinated in Li17Ge4, whereas in Li16.38Ge4 the Ge atoms possess coordination numbers 12 and 13. Regarding the thermodynamic stability, Li16.38Ge4 is assigned a high-temperature phase existing between ∼400 °C and 627 °C, whereas Li17Ge4 decomposes peritectically at 520-522 °C. Additionally, the decomposition of Li16.38Ge4 below ∼400 °C was found to be very sluggish. These findings are manifested by differential scanning calorimetry, long-term annealing experiments and the results from melt equilibration experiments. Interestingly, the thermodynamic properties of the lithium-rich tetrelides Li17Tt4 and Li4.1Tt (Li16.4Tt4) are very similar (Tt = Si, Ge). Besides Li15Tt4, Li14Tt6, Li12Tt7, and LiTt, the title compounds are further examples of isotypic tetrelides in the systems Li-Tt.

  16. Effective Geothermal Utilisation close to the surface by the TT-Geothermal Radial Drilling (GRD-Method

    Directory of Open Access Journals (Sweden)

    Hans-Joachim Bayer

    2007-01-01

    Full Text Available In the late 1970-Years, Tracto-Technik developped a very effective radial-shaped percussion system for a geothermal heating, the ECOtherm-System, which was very well accepted by customers. Nowadays, a radial-shaped drilling system, operating some decameters below the surface, was developped by Tracto-Technik, which offers the chance of a very effective drilling for the use of geothermal energy. The main advantage of this development is the reduction of drilling costs by new constructions and new handling possibilities. Drilling processes like the rod connecting or the drill-hole enlargement were solved in other ways as usual, by very time-shortening and effective ways, which are presented in the paper. The new TT-Geothermal radial drilling methods need only a very small but highly effective drilling unit, which reduces the operational drilling cost in a enormous way. All operational drilling steps are reduced to less than a half time as usual. By these GRD-methods, the use of surface-close geothermal energy is simplified and less expansive.

  17. Chymotrypsinogen C Genetic Variants, Including c.180TT, Are Strongly Associated With Chronic Pancreatitis in Pediatric Patients.

    Science.gov (United States)

    Grabarczyk, Alicja Monika; Oracz, Grzegorz; Wertheim-Tysarowska, Katarzyna; Kujko, Aleksandra Anna; Wejnarska, Karolina; Kolodziejczyk, Elwira; Bal, Jerzy; Koziel, Dorota; Kowalik, Artur; Gluszek, Stanislaw; Rygiel, Agnieszka Magdalena

    2017-12-01

    Genetic studies in adults/adolescent patients with chronic pancreatitis (CP) identified chymotrypsinogen C (CTRC) genetic variants but their association with CP risk has been difficult to replicate. To evaluate the risk of CP associated with CTRC variants in CP pediatric patients-control study. The distribution of CTRC variants in CP pediatric cohort (n = 136, median age at CP onset 8 years) with no history of alcohol/smoking abuse was compared with controls (n = 401, median age 45). We showed that p.Arg254Trp (4.6%) and p.Lys247_Arg254del (5.3%) heterozygous mutations are frequent and significantly associated with CP risk in pediatric patients (odds ratio [OR] = 19.1; 95% CI 2.8-160; P = 0.001 and OR = 5.5; 95% CI 1.6-19.4; P = 0.001, respectively). For the first time, we demonstrated that the c.180TT genotype of common p.Gly60Gly variant is strong, an independent CP risk factor (OR = 23; 95% CI 7.7-70; P A variant, both CA and AA genotype, is significantly underrepresented in CP compared with controls (15% vs 35%; OR = 0.33; 95% CI 0.19-0.59; P risk factors. The c.493+51C>A variant may play a protective role against CP development.

  18. Exogenous Cortisol Administration; Effects on Risk Taking Behavior, Exercise Performance, and Physiological and Neurophysiological Responses.

    Science.gov (United States)

    Robertson, Caroline V; Immink, Maarten A; Marino, Frank E

    2016-01-01

    Rationale: Exogenous cortisol is a modulator of behavior related to increased motivated decision making (Putman et al., 2010), where risky choices yield potentially big reward. Making risk based judgments has been shown to be important to athletes in optimizing pacing during endurance events (Renfree et al., 2014; Micklewright et al., 2015). Objectives: Therefore, the aims of this study were to examine the effect of 50 mg exogenous cortisol on neurophysiological responses and risk taking behavior in nine healthy men. Further to this, to examine the effect of exogenous cortisol on exercise performance. Methods: Using a double blind counterbalanced design, cyclists completed a placebo (PLA), and a cortisol (COR) trial (50 mg cortisol), with drug ingestion at 0 min. Each trial consisted of a rest period from 0 to 60 min, followed by a risk taking behavior task, a 30 min time trial (TT) with 5 × 30 s sprints at the following time intervals; 5, 11, 17, 23, and 29 min. Salivary cortisol (SaCOR), Electroencephalography (EEG) and Near Infrared Spectroscopy (NIRs) were measured at 15, 30, 45, and 60 min post-ingestion. Glucose and lactate samples were taken at 0 and 60 min post-ingestion. During exercise, power output (PO), heart rate (HR), EEG, and NIRS were measured. SaCOR was measured 10 min post-exercise. Results: Cortisol increased risk taking behavior from baseline testing. This was in line with significant neurophysiological changes at rest and during exercise. At rest, SaCOR levels were higher ( P exogenous cortisol on exercise performance. These results are in line with previous research showing altered risk taking behavior following exogenous cortisol, however the altered behavior did not translate into changes in exercise performance.

  19. i,tt r

    African Journals Online (AJOL)

    In Suid-Afrika sowel as in Afrika kom daar jaar- liks groot hoeveelhede laegraadse ruvoer beskikbaar in die vorm van strooie van die gmanbedryf. begasse van die suikerbedryf en swak gehalte grashooie vanwed on- gunstige weersomstandighede tydens die hooiseisoen. Hoewel hierdie laegraadse nrvoere dieselfde ...

  20. SSS* = AB+TT

    NARCIS (Netherlands)

    A. Plaat (Aske); J. Schaeffer; W.H.L.M. Pijls (Wim); A. de Bruin (Arie)

    1995-01-01

    textabstractIn 1979 Stockman introduced the SSS* minimax search algorithm that dominates alpha-beta in the number of leaf nodes expanded. Further investigation of the algorithm showed that it had three serious drawbacks, which prevented its use by practitioners: it is difficult to understand, it has

  1. Living for Six Days at 2200 M Improves Time-Trial Performance of Sea-Level Residents Exposed to 4300 M

    National Research Council Canada - National Science Library

    Fulco, Charles S; Muza, Stephen R; Beidleman, Beth; Jones, Juli; Lammi, Eric; Staab, Janet; Rock, Paul B; Kambis, Kenneth; Glickman, Ellen; Doan, Brandon K; Brothers, Michael D; Zupan, Michael F; Cymerman, Allen

    2008-01-01

    ... and reducing acute mountain sickness incidence and severity during subsequent high altitude exposure The data presented here will be focused on the effects of staging at moderate altitude on prolonged endurance...

  2. arXiv Test beam measurement of the first prototype of the fast silicon pixel monolithic detector for the TT-PET project

    CERN Document Server

    Paolozzi, L.; Benoit, M.; Cardarelli, R.; Débieux, S.; Forshaw, D.; Hayakawa, D.; Iacobucci, G.; Kaynak, M.; Miucci, A.; Nessi, M.; Ratib, O.; Ripiccini, E.; Rücker, H.; Valerio, P.; Weber, M.

    2018-04-12

    The TT-PET collaboration is developing a PET scanner for small animals with  30 ps  time-of-flight resolution and sub-millimetre 3D detection granularity. The sensitive element of the scanner is a monolithic silicon pixel detector based on state-of-the-art SiGe BiCMOS technology. The first ASIC prototype for the TT-PET was produced and tested in the laboratory and with minimum ionizing particles. The electronics exhibit an equivalent noise charge below  600 e− RMS  and a pulse rise time of less than  2 ns , in accordance with the simulations. The pixels with a capacitance of  0.8 pF  were measured to have a detection efficiency greater than  99%  and, although in the absence of the post-processing, a time resolution of approximately  200 ps .

  3. Measurement of the tt production cross section in pp collisions at square root of s = 1.96 TeV.

    Science.gov (United States)

    Abulencia, A; Acosta, D; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J-F; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Bachacou, H; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Belloni, A; Ben Haim, E; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carron, S; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chapman, J; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Chu, P H; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciljak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Cresciolo, F; Cruz, A; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cyr, D; DaRonco, S; D'Auria, S; D'Onofrio, M; Dagenhart, D; de Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; Dell'Orso, M; Delli Paoli, F; Demers, S; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Dionisi, C; Dittmann, J R; DiTuro, P; Dörr, C; Donati, S; Donega, M; Dong, P; Donini, J; Dorigo, T; Dube, S; Ebina, K; Efron, J; Ehlers, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Field, R; Flanagan, G; Flores-Castillo, L R; Foland, A; Forrester, S; Foster, G W; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garcia, J E; Garcia Sciveres, M; Garfinkel, A F; Gay, C; Gerberich, H; Gerdes, D; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Ginsburg, C; Giokaris, N; Giolo, K; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Gotra, Y; Goulianos, K; Gresele, A; Griffiths, M; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, S R; Hahn, K; Halkiadakis, E; Hamilton, A; Han, B-Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, M; Harper, S; Harr, R F; Harris, R M; Hatakeyama, K; Hauser, J; Hays, C; Heijboer, A; Heinemann, B; Heinrich, J; Herndon, M; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ishizawa, Y; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jensen, H; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Kang, J; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kobayashi, H; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kovalev, A; Kraan, A; Kraus, J; Kravchenko, I; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, J; Lee, J; Lee, Y J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Liss, T M; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P; Lu, R-S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Maki, T; Maksimovic, P; Malde, S; Manca, G; Margaroli, F; Marginean, R; Marino, C; Martin, A; Martin, V; Martínez, M; Maruyama, T; Mastrandrea, P; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McFarlane, M; McIntyre, P; McNulty, R; Mehta, A; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; von der Mey, M; Miao, T; Miladinovic, N; Miles, J; Miller, R; Miller, J S; Mills, C; Milnik, M; Miquel, R; Mitra, A; Mitselmakher, G; Miyamoto, A; Moggi, N; Mohr, B; Moore, R; Morello, M; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Nachtman, J; Naganoma, J; Nahn, S; Nakano, I; Napier, A; Naumov, D; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nigmanov, T; Nodulman, L; Norniella, O; Nurse, E; Ogawa, T; Oh, S H; Oh, Y D; Okusawa, T; Oldeman, R; Orava, R; Osterberg, K; Pagliarone, C; Palencia, E; Paoletti, R; Papadimitriou, V; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Rakitin, A; Rappoccio, S; Ratnikov, F; Reisert, B; Rekovic, V; van Remortel, N; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robertson, W J; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Rott, C; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Sabik, S; Safonov, A; Sakumoto, W K; Salamanna, G; Saltó, O; Saltzberg, D; Sanchez, C; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfiligoi, I; Shapiro, M D; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakyan, A; Sjolin, J; Skiba, A; Slaughter, A J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Soderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spezziga, M; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tanimoto, N; Tecchio, M; Teng, P K; Terashi, K; Tether, S; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Tönnesmann, M; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuchiya, R; Tsuno, S; Turini, N; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vaiciulis, A; Vallecorsa, S; Varganov, A; Vataga, E; Velev, G; Veramendi, G; Veszpremi, V; Vidal, R; Vila, I; Vilar, R; Vine, T; Vollrath, I; Volobouev, I; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wallny, R; Walter, T; Wan, Z; Wang, S M; Warburton, A; Waschke, S; Waters, D; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhang, X; Zhou, J; Zucchelli, S

    2006-08-25

    We present a measurement of the top quark pair production cross section in pp collisions at square root of s = 1.96 TeV using 318 pb(-1) of data collected with the Collider Detector at Fermilab. We select tt[over ] decays into the final states enu+jets and mu nu+ jets, in which at least one b quark from the t-quark decays is identified using a secondary vertex-finding algorithm. Assuming a top quark mass of 178 GeV/c2, we measure a cross section of 8.7 +/- 0.9(stat)(-0.9)+1.1(syst) pb. We also report the first observation of tt[over ] with significance greater than 5sigma in the subsample in which both b quarks are identified, corresponding to a cross section of 10.1(-1.4)+1.6(stat)(-1.3)+2.0(syst) pb.

  4. Search for CP violation in tt̄ production and decay in proton-proton collisions at √s=8 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Khachatryan, V.; Sirunyan, A.M.; Tumasyan, A. [Yerevan Physics Institute, Yerevan (Armenia); Adam, W. [Institut für Hochenergiephysik, Wien (Austria); Collaboration: The CMS collaboration; and others

    2017-03-20

    The results of a first search for CP violation in the production and decay of top quark-antiquark (tt̄) pairs are presented. The search is based on asymmetries in T-odd, triple-product correlation observables, where T is the time-reversal operator. The analysis uses a sample of proton-proton collisions at √s=8 TeV collected by the CMS experiment, corresponding to an integrated luminosity of 19.7 fb{sup −1}. Events are selected having one electron or muon and at least four jets. The T-odd observables are measured using four-momentum vectors associated with tt̄ production and decay. The measured asymmetries exhibit no evidence for CP-violating effects, consistent with the expectation from the standard model.

  5. Search for the 125 GeV Higgs boson in the ttH production mode with the ATLAS detector (ID#99)

    CERN Document Server

    Hu, Shuyang; The ATLAS collaboration

    2017-01-01

    This poster presents the results of a combined ttH search in the γγ, multilepton and bb decay channels using up to 13.3 fb-1 of proton-proton collison data at sqrt(s)=13 TeV collected with the ATLAS detector at the LHC. The poster is to be shown at PANIC17, which will be held in Beijing from Sep 1st to Sep 5th.

  6. Tc-MYBPA an Arabidopsis TT2-like transcription factor and functions in the regulation of proanthocyanidin synthesis in Theobroma cacao.

    Science.gov (United States)

    Liu, Yi; Shi, Zi; Maximova, Siela N; Payne, Mark J; Guiltinan, Mark J

    2015-06-25

    The flavan-3-ols catechin and epicatechin, and their polymerized oligomers, the proanthocyanidins (PAs, also called condensed tannins), accumulate to levels of up to 15 % of the total weight of dry seeds of Theobroma cacao L. These compounds have been associated with several health benefits in humans. They also play important roles in pest and disease defense throughout the plant. In Arabidopsis, the R2R3 type MYB transcription factor TT2 regulates the major genes leading to the synthesis of PA. To explore the transcriptional regulation of the PA synthesis pathway in cacao, we isolated and characterized an R2R3 type MYB transcription factor MYBPA from cacao. We examined the spatial and temporal gene expression patterns of the Tc-MYBPA gene and found it to be developmentally expressed in a manner consistent with its involvement in PAs and anthocyanin synthesis. Functional complementation of an Arabidopsis tt2 mutant with Tc-MYBPA suggested that it can functionally substitute the Arabidopsis TT2 gene. Interestingly, in addition to PA accumulation in seeds of the Tc-MYBPA expressing plants, we also observed an obvious increase of anthocyanidin accumulation in hypocotyls. We observed that overexpression of the Tc-MYBPA gene resulted in increased expression of several key genes encoding the major structural enzymes of the PA and anthocyanidin pathway, including DFR (dihydroflavanol reductase), LDOX (leucoanthocyanidin dioxygenase) and BAN (ANR, anthocyanidin reductase). We conclude that the Tc-MYBPA gene that encodes an R2R3 type MYB transcription factor is an Arabidopsis TT2 like transcription factor, and may be involved in the regulation of both anthocyanin and PA synthesis in cacao. This research may provide molecular tools for breeding of cacao varieties with improved disease resistance and enhanced flavonoid profiles for nutritional and pharmaceutical applications.

  7. Measurement of the top quark mass with the template method in the ttˉ→lepton+jets channel using ATLAS data

    NARCIS (Netherlands)

    Aad, G.; et al., [Unknown; Bentvelsen, S.; Colijn, A.P.; de Jong, P.; de Nooij, L.; Doxiadis, A.D.; Garitaonandia, H.; Geerts, D.A.A.; Gosselink, M.; Kayl, M.S.; Koffeman, E.; Lee, H.; Linde, F.; Mechnich, J.; Mussche, I.; Ottersbach, J.P.; Rijpstra, M.; Ruckstuhl, N.; Tsiakiris, M.; van der Kraaij, E.; van der Leeuw, R.; van der Poel, E.; van Kesteren, Z.; van Vulpen, I.; Vermeulen, J.C.; Vreeswijk, M.

    2012-01-01

    The top quark mass has been measured using the template method in the ttˉ→lepton+jets channel based on data recorded in 2011 with the ATLAS detector at the LHC. The data were taken at a proton-proton centre-of-mass energy of √s = 7 TeV and correspond to an integrated luminosity of 1.04 fb−1. The

  8. TT Mutant Homozygote of Kruppel-like Factor 5 Is a Key Factor for Increasing Basal Metabolic Rate and Resting Metabolic Rate in Korean Elementary School Children.

    Science.gov (United States)

    Choi, Jung Ran; Kwon, In-Su; Kwon, Dae Young; Kim, Myung-Sunny; Lee, Myoungsook

    2013-12-01

    We investigated the contribution of genetic variations of KLF5 to basal metabolic rate (BMR) and resting metabolic rate (RMR) and the inhibition of obesity in Korean children. A variation of KLF5 (rs3782933) was genotyped in 62 Korean children. Using multiple linear regression analysis, we developed a model to predict BMR in children. We divided them into several groups; normal versus overweight by body mass index (BMI) and low BMR versus high BMR by BMR. There were no differences in the distributions of alleles and genotypes between each group. The genetic variation of KLF5 gene showed a significant correlation with several clinical factors, such as BMR, muscle, low-density lipoprotein cholesterol, and insulin. Children with the TT had significantly higher BMR than those with CC (p = 0.030). The highest muscle was observed in the children with TT compared with CC (p = 0.032). The insulin and C-peptide values were higher in children with TT than those with CC (p= 0.029 vs. p = 0.004, respectively). In linear regression analysis, BMI and muscle mass were correlated with BMR, whereas insulin and C-peptide were not associated with BMR. In the high-BMR group, we observed that higher muscle, fat mass, and C-peptide affect the increase of BMR in children with TT (p BMR (adjust r(2) = 1.000, p BMR in Korean children. We could make better use of the variation within KLF5 in a future clinical intervention study of obesity.

  9. Site-targeted complement inhibition by a complement receptor 2-conjugated inhibitor (mTT30) ameliorates post-injury neuropathology in mouse brains.

    Science.gov (United States)

    Rich, Megan C; Keene, Chesleigh N; Neher, Miriam D; Johnson, Krista; Yu, Zhao-Xue; Ganivet, Antoine; Holers, V Michael; Stahel, Philip F

    2016-03-23

    Intracerebral complement activation after severe traumatic brain injury (TBI) leads to a cascade of neuroinflammatory pathological sequelae that propagate host-mediated secondary brain injury and adverse outcomes. There are currently no specific pharmacological agents on the market to prevent or mitigate the development of secondary cerebral insults after TBI. A novel chimeric CR2-fH compound (mTT30) provides targeted inhibition of the alternative complement pathway at the site of tissue injury. This experimental study was designed to test the neuroprotective effects of mTT30 in a mouse model of closed head injury. The administration of 500 μg mTT30 i.v. at 1 h, 4 h and 24 h after head injury attenuated complement C3 deposition in injured brains, reduced the extent of neuronal cell death, and decreased post-injury microglial activation, compared to vehicle-injected placebo controls. These data imply that site-targeted alternative pathway complement inhibition may represent a new promising therapeutic avenue for the future management of severe TBI. Copyright © 2016. Published by Elsevier Ireland Ltd.

  10. Measurement of the top quark mass in the tt¯→dilepton channel from s=8 TeV ATLAS data

    Directory of Open Access Journals (Sweden)

    M. Aaboud

    2016-10-01

    Full Text Available The top quark mass is measured in the tt¯→dilepton channel (lepton=e,μ using ATLAS data recorded in the year 2012 at the LHC. The data were taken at a proton–proton centre-of-mass energy of s=8 TeV and correspond to an integrated luminosity of about 20.2 fb−1. Exploiting the template method, and using the distribution of invariant masses of lepton–b-jet pairs, the top quark mass is measured to be mtop=172.99±0.41 (stat±0.74 (syst GeV, with a total uncertainty of 0.84 GeV. Finally, a combination with previous ATLAS mtop measurements from s=7 TeV data in the tt¯→dilepton and tt¯→lepton+jets channels results in mtop=172.84±0.34 (stat±0.61 (syst GeV, with a total uncertainty of 0.70 GeV.

  11. THE EFFECT OF PROBLEM SOLVING LEARNING MODEL BASED JUST IN TIME TEACHING (JiTT ON SCIENCE PROCESS SKILLS (SPS ON STRUCTURE AND FUNCTION OF PLANT TISSUE CONCEPT

    Directory of Open Access Journals (Sweden)

    Resha Maulida

    2017-11-01

    Full Text Available The purpose of this study was to determine the effect of Problem Solving learning model based Just in Time Teaching (JiTT on students' science process skills (SPS on structure and function of plant tissue concept. This research was conducted at State Senior High School in South Tangerang .The research conducted using the quasi-experimental with Nonequivalent pretest-Postest Control Group Design. The samples of this study were 34 students for experimental group and 34 students for the control group. Data was obtained using a process skill test instrument (essai type that has been tested for its validity and reliability. Result of data analysis by ANACOVA, show that there were significant difference of postest between experiment and control group, by controlling the pretest score (F = 4.958; p <0.05. Thus, the problem-solving learning based on JiTT proved to improve students’ SPS. The contribution of this treatment in improving the students’ SPS was 7.2%. This shows that there was effect of problem solving model based JiTT on students’ SPS on the Structure and function of plant tissue concept.

  12. Multi-modal exercise training and protein-pacing enhances physical performance adaptations independent of growth hormone and BDNF but may be dependent on IGF-1 in exercise-trained men.

    Science.gov (United States)

    Ives, Stephen J; Norton, Chelsea; Miller, Vincent; Minicucci, Olivia; Robinson, Jake; O'Brien, Gabe; Escudero, Daniela; Paul, Maia; Sheridan, Caitlin; Curran, Kathryn; Rose, Kayla; Robinson, Nathaniel; He, Feng; Arciero, Paul J

    2017-02-01

    Protein-pacing (P; 5-6meals/day @ 2.0g/kgBW/day) and multi-mode exercise (RISE; resistance, interval, stretching, endurance) training (PRISE) improves muscular endurance, strength, power and arterial health in exercise-trained women. The current study extends these findings by examining PRISE on fitness, growth hormone (GH), insulin-like growth factor-1 (IGF-1), and brain-derived neurotrophic factor (BDNF) response, cardiometabolic health, and body composition in exercise-trained men. Twenty active males (>4daysexercise/week) completed either: PRISE (n=11) or RISE (5-6meals/day @ 1.0g/kgBW/day; n=9) for 12weeks. Muscular strength (1-repetition maximum bench and leg press, 1-RM BP, and 1-RM LP), endurance (sit-ups, SU; push-ups, PU), power (squat jump, SJ, and bench throw, BT), flexibility (sit-and-reach, SR), aerobic performance (5km cycling time-trial, TT), GH, IGF-1, BDNF, augmentation index, (AIx), and body composition, were assessed at weeks 0 (pre) and 13 (post). At baseline, no differences existed between groups except for GH (RISE, 230±13 vs. PRISE, 382±59pg/ml, pIGF-1 (12%, pIGF-1 response. Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  13. Short-term heat acclimation improves the determinants of endurance performance and 5-km running performance in the heat.

    Science.gov (United States)

    James, Carl A; Richardson, Alan J; Watt, Peter W; Willmott, Ashley G B; Gibson, Oliver R; Maxwell, Neil S

    2017-03-01

    This study investigated the effect of 5 days of controlled short-term heat acclimation (STHA) on the determinants of endurance performance and 5-km performance in runners, relative to the impairment afforded by moderate heat stress. A control group (CON), matched for total work and power output (2.7 W·kg -1 ), differentiated thermal and exercise contributions of STHA on exercise performance. Seventeen participants (10 STHA, 7 CON) completed graded exercise tests (GXTs) in cool (13 °C, 50% relative humidity (RH), pre-training) and hot conditions (32 °C, 60% RH, pre- and post-training), as well as 5-km time trials (TTs) in the heat, pre- and post-training. STHA reduced resting (p = 0.01) and exercising (p = 0.04) core temperature alongside a smaller change in thermal sensation (p = 0.04). Both groups improved the lactate threshold (LT, p = 0.021), lactate turnpoint (LTP, p = 0.005) and velocity at maximal oxygen consumption (vV̇O 2max ; p = 0.031) similarly. Statistical differences between training methods were observed in TT performance (STHA, -6.2(5.5)%; CON, -0.6(1.7)%, p = 0.029) and total running time during the GXT (STHA, +20.8(12.7)%; CON, +9.8(1.2)%, p = 0.006). There were large mean differences in change in maximal oxygen consumption between STHA +4.0(2.2) mL·kg -1 ·min -1 (7.3(4.0)%) and CON +1.9(3.7) mL·kg -1 ·min -1 (3.8(7.2)%). Running economy (RE) deteriorated following both training programmes (p = 0.008). Similarly, RE was impaired in the cool GXT, relative to the hot GXT (p = 0.004). STHA improved endurance running performance in comparison with work-matched normothermic training, despite equality of adaptation for typical determinants of performance (LT, LTP, vV̇O 2max ). Accordingly, these data highlight the ergogenic effect of STHA, potentially via greater improvements in maximal oxygen consumption and specific thermoregulatory and associated thermal perception adaptations absent in normothermic training.

  14. Effect of a serogroup A meningococcal conjugate vaccine (PsA-TT) on serogroup A meningococcal meningitis and carriage in Chad: a community study [corrected].

    Science.gov (United States)

    Daugla, D M; Gami, J P; Gamougam, K; Naibei, N; Mbainadji, L; Narbé, M; Toralta, J; Kodbesse, B; Ngadoua, C; Coldiron, M E; Fermon, F; Page, A-L; Djingarey, M H; Hugonnet, S; Harrison, O B; Rebbetts, L S; Tekletsion, Y; Watkins, E R; Hill, D; Caugant, D A; Chandramohan, D; Hassan-King, M; Manigart, O; Nascimento, M; Woukeu, A; Trotter, C; Stuart, J M; Maiden, McJ; Greenwood, B M

    2014-01-04

    A serogroup A meningococcal polysaccharide-tetanus toxoid conjugate vaccine (PsA-TT, MenAfriVac) was licensed in India in 2009, and pre-qualified by WHO in 2010, on the basis of its safety and immunogenicity. This vaccine is now being deployed across the African meningitis belt. We studied the effect of PsA-TT on meningococcal meningitis and carriage in Chad during a serogroup A meningococcal meningitis epidemic. We obtained data for the incidence of meningitis before and after vaccination from national records between January, 2009, and June, 2012. In 2012, surveillance was enhanced in regions where vaccination with PsA-TT had been undertaken in 2011, and in one district where a reactive vaccination campaign in response to an outbreak of meningitis was undertaken. Meningococcal carriage was studied in an age-stratified sample of residents aged 1-29 years of a rural area roughly 13-15 and 2-4 months before and 4-6 months after vaccination. Meningococci obtained from cerebrospinal fluid or oropharyngeal swabs were characterised by conventional microbiological and molecular methods. Roughly 1·8 million individuals aged 1-29 years received one dose of PsA-TT during a vaccination campaign in three regions of Chad in and around the capital N'Djamena during 10 days in December, 2011. The incidence of meningitis during the 2012 meningitis season in these three regions was 2·48 per 100,000 (57 cases in the 2·3 million population), whereas in regions without mass vaccination, incidence was 43·8 per 100,000 (3809 cases per 8·7 million population), a 94% difference in crude incidence (pvaccinated regions. 32 serogroup A carriers were identified in 4278 age-stratified individuals (0·75%) living in a rural area near the capital 2-4 months before vaccination, whereas only one serogroup A meningococcus was isolated in 5001 people living in the same community 4-6 months after vaccination (adjusted odds ratio 0·019, 95% CI 0·002-0·138; p<0·0001). PSA-TT was highly

  15. Summary of the OECD/NRC Boiling Water Reactor Turbine Trip Benchmark - Fourth Workshop (BWR-TT4)

    International Nuclear Information System (INIS)

    2002-01-01

    The reference problem chosen for simulation in a BWR is a Turbine Trip transient, which begins with a sudden Turbine Stop Valve (TSV) closure. The pressure oscillation generated in the main steam piping propagates with relatively little attenuation into the reactor core. The induced core pressure oscillation results in dramatic changes of the core void distribution and fluid flow. The magnitude of the neutron flux transient taking place in the BWR core is strongly affected by the initial rate of pressure rise caused by pressure oscillation and has a strong spatial variation. The correct simulation of the power response to the pressure pulse and subsequent void collapse requires a 3-D core modeling supplemented by 1-D simulation of the remainder of the reactor coolant system. A BWR TT benchmark exercise, based on a well-defined problem with complete set of input specifications and reference experimental data, has been proposed for qualification of the coupled 3-D neutron kinetics/thermal-hydraulic system transient codes. Since this kind of transient is a dynamically complex event with reactor variables changing very rapidly, it constitutes a good benchmark problem to test the coupled codes on both levels: neutronics/thermal-hydraulic coupling and core/plant system coupling. Subsequently, the objectives of the proposed benchmark are: comprehensive feedback testing and examination of the capability of coupled codes to analyze complex transients with coupled core/plant interactions by comparison with actual experimental data. The benchmark consists of three separate exercises: Exercise 1 - Power vs. Time Plant System Simulation with Fixed Axial Power Profile Table (Obtained from Experimental Data). Exercise 2 - Coupled 3-D Kinetics/Core Thermal-Hydraulic BC Model and/or 1-D Kinetics Plant System Simulation. Exercise 3 - Best-Estimate Coupled 3-D Core/Thermal-Hydraulic System Modeling. The purpose of this fourth workshop was to present and discuss final results of

  16. Effects of Tribulus terrestris saponins on exercise performance in overtraining rats and the underlying mechanisms.

    Science.gov (United States)

    Yin, Liang; Wang, Qian; Wang, Xiaohui; Song, Liang-Nian

    2016-06-22

    The objective of this study was to determine the effects of Tribulus terrestris L. (TT) saponins on exercise performance and the underlying mechanisms. A rat overtraining model was established and animals were treated with TT extracts (120 mg/kg body mass) 30 min before each training session. Serum levels of testosterone and corticosterone and levels of androgen receptor (AR) and insulin growth factor-1 receptor (IGF-1R) in the liver, gastrocnemius, and soleus were determined by ELISA and Western blot. Treatment of rats with TT saponins significantly improved the performance of the overtraining rats, reflected by the extension of time to exhaustion, with a concomitant increase in body mass, relative mass, and protein levels of gastrocnemius. Overtraining alone induced a significant decrease in the serum level of testosterone. In contrast, treatment with TT saponins dramatically increased the serum level of testosterone in overtraining rats to about 150% of control and 216% of overtraining groups, respectively. In addition, TT saponins resulted in a further significant increase in AR in gastrocnemius and significantly suppressed the overtraining-induced increase in IGF-1R in the liver. These results indicated that TT saponins increased performance, body mass, and gastrocnemius mass of rats undergoing overtraining, which might be attributed to the changes in androgen-AR axis and IGF-1R signaling.

  17. Measurements of the top-quark mass and the tt cross section in the hadronic τ+jets decay channel at sqrt[s] = 1.96 TeV.

    Science.gov (United States)

    Aaltonen, T; Álvarez González, B; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Appel, J A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Auerbach, B; Aurisano, A; Azfar, F; Badgett, W; Bae, T; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauce, M; Bedeschi, F; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Bisello, D; Bizjak, I; Bland, K R; Blumenfeld, B; Bocci, A; Bodek, A; Bortoletto, D; Boudreau, J; Boveia, A; Brigliadori, L; Bromberg, C; Brucken, E; Budagov, J; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Calamba, A; Calancha, C; Camarda, S; Campanelli, M; Campbell, M; Canelli, F; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chung, W H; Chung, Y S; Ciocci, M A; Clark, A; Clarke, C; Compostella, G; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Crescioli, F; Cuevas, J; Culbertson, R; Dagenhart, D; d'Ascenzo, N; Datta, M; de Barbaro, P; Dell'orso, M; Demortier, L; Deninno, M; Devoto, F; d'Errico, M; Di Canto, A; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Dorigo, M; Dorigo, T; Ebina, K; Elagin, A; Eppig, A; Erbacher, R; Errede, S; Ershaidat, N; Eusebi, R; Farrington, S; Feindt, M; Fernandez, J P; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Funakoshi, Y; Furic, I; Gallinaro, M; Garcia, J E; Garfinkel, A F; Garosi, P; Gerberich, H; Gerchtein, E; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Ginsburg, C M; Giokaris, N; Giromini, P; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldin, D; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Grinstein, S; Grosso-Pilcher, C; Group, R C; Guimaraes da Costa, J; Hahn, S R; Halkiadakis, E; Hamaguchi, A; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harr, R F; Hatakeyama, K; Hays, C; Heck, M; Heinrich, J; Herndon, M; Hewamanage, S; Hocker, A; Hopkins, W; Horn, D; Hou, S; Hughes, R E; Hurwitz, M; Husemann, U; Hussain, N; Hussein, M; Huston, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jindariani, S; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Karchin, P E; Kasmi, A; Kato, Y; Ketchum, W; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kim, Y J; Kimura, N; Kirby, M; Klimenko, S; Knoepfel, K; Kondo, K; Kong, D J; Konigsberg, J; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Kruse, M; Krutelyov, V; Kuhr, T; Kurata, M; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lecompte, T; Lee, E; Lee, H S; Lee, J S; Lee, S W; Leo, S; Leone, S; Lewis, J D; Limosani, A; Lin, C-J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, H; Liu, Q; Liu, T; Lockwitz, S; Loginov, A; Lucchesi, D; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lys, J; Lysak, R; Madrak, R; Maeshima, K; Maestro, P; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Martínez, M; Mastrandrea, P; Matera, K; Mattson, M E; Mazzacane, A; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Mesropian, C; Miao, T; Mietlicki, D; Mitra, A; Miyake, H; Moed, S; Moggi, N; Mondragon, M N; Moon, C S; Moore, R; Morello, M J; Morlock, J; Movilla Fernandez, P; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakano, I; Napier, A; Nett, J; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Noh, S Y; Norniella, O; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Ortolan, L; Pagan Griso, S; Pagliarone, C; Palencia, E; Papadimitriou, V; Paramonov, A A; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pilot, J; Pitts, K; Plager, C; Pondrom, L; Poprocki, S; Potamianos, K; Prokoshin, F; Pranko, A; Ptohos, F; Punzi, G; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Renton, P; Rescigno, M; Riddick, T; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Ruffini, F; Ruiz, A; Russ, J; Rusu, V; Safonov, A; Sakumoto, W K; Sakurai, Y; Santi, L; Sato, K; Saveliev, V; Savoy-Navarro, A; Schlabach, P; Schmidt, A; Schmidt, E E; Schwarz, T; Scodellaro, L; Scribano, A; Scuri, F; Seidel, S; Seiya, Y; Semenov, A; Sforza, F; Shalhout, S Z; Shears, T; Shepard, P F; Shimojima, M; Shochet, M; Shreyber-Tecker, I; Simonenko, A; Sinervo, P; Sliwa, K; Smith, J R; Snider, F D; Soha, A; Sorin, V; Song, H; Squillacioti, P; Stancari, M; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Strycker, G L; Sudo, Y; Sukhanov, A; Suslov, I; Takemasa, K; Takeuchi, Y; Tang, J; Tecchio, M; Teng, P K; Thom, J; Thome, J; Thompson, G A; Thomson, E; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Totaro, P; Trovato, M; Ukegawa, F; Uozumi, S; Varganov, A; Vázquez, F; Velev, G; Vellidis, C; Vidal, M; Vila, I; Vilar, R; Vizán, J; Vogel, M; Volpi, G; Wagner, P; Wagner, R L; Wakisaka, T; Wallny, R; Wang, S M; Warburton, A; Waters, D; Wester, W C; Whiteson, D; Wicklund, A B; Wicklund, E; Wilbur, S; Wick, F; Williams, H H; Wilson, J S; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, H; Wright, T; Wu, X; Wu, Z; Yamamoto, K; Yamato, D; Yang, T; Yang, U K; Yang, Y C; Yao, W-M; Yeh, G P; Yi, K; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanetti, A; Zeng, Y; Zhou, C; Zucchelli, S

    2012-11-09

    We present the first direct measurement of the top-quark mass using tt events decaying in the hadronic τ+jets decay channel. Using data corresponding to an integrated luminosity of 2.2 fb(-1) collected by the CDF II detector in pp collisions at sqrt[s] = 1.96 TeV at the Fermilab Tevatron, we measure the tt cross section, σ(tt), and the top-quark mass, M(top). We extract M(top) from a likelihood based on per-event probabilities calculated with leading-order signal and background matrix elements. We measure σ(tt) = 8.8 ± 3.3(stat) ± 2.2(syst) pb and M(top) = 172.7 ± 9.3(stat) ± 3.7(syst) GeV/c(2).

  18. Influence of the Co-Administration of Heptavalent Conjugate Vaccine PCV7-TT on the Immunological Response Elicited by VA-MENGOC-BC® and Heberpenta®-L in Rabbits.

    Science.gov (United States)

    Espinosa-Viñals, Carlos; García-Rivera, Dagmar; Rodríguez Noda, Laura; Amador Gómez, Aylín; Nicot, Milagros; Valle, Orialys; Núñez, Juan F; Martin, Yanet; Santana, Darielys; Valdés, Yury; Vérez Bencomo, Vicente

    2017-05-01

    Finlay Vaccine Institute is developing a new heptavalent conjugate vaccine against Streptococcus pneumoniae. As infants are the target population, PCV7-TT will be necessarily co-administered with other vaccines, and then, the interactions represent a concern. The aim of this work is to evaluate the possible immunological interferences in rabbits as animal experimental model. Rabbits were immunized with Heberpenta®-L, VA-MENGOC-BC®, and PCV7-TT. Blood samples were taken fourteen days after final immunization for obtaining sera. Antibody responses to all antigens were evaluated by indirect ELISA. Functional responses against diphtheria and tetanus toxoid were done by in vivo seroneutralization assay. No interference was observed by PCV7-TT over the humoral response against diphtheria toxoid and meningococcal antigens (p > 0.05). A nonstatistically significant reduction (p > 0.05) was observed in the case of the humoral response against Haemophilus influenzae type b oligosaccharide. Concomitant administration of Heberpenta®-L and PCV7-TT increased twice the antibody titers as well as the protective activity against tetanus toxoid, but no statistical differences were found. The co-administration did not induce a reduction in the percent of responders against pneumococcal polysaccharides contained in PCV7-TT vaccine. Concomitant administration of PCV7-TT did not induce interferences over the evaluated antigens of Heberpenta®-L and VA-MENGOC-BC®. Also, no interference was observed on the immune response elicited by PCV7-TT. These preclinical results suggest that PCV7-TT will not result in a serious problem over the immune response elicited by the licensed vaccines Heberpenta®-L and VA-MENGOC-BC®. However, the clinical interference could be strictly studied during clinical trials in infants.

  19. Studies of tt+cc production with MadGraph5_aMC@NLO and Herwig++ for the ATLAS experiment

    CERN Document Server

    The ATLAS collaboration

    2016-01-01

    Studies of the simulation of ttcc at the LHC, at a centre-of-mass energy of 13 TeV, based on next-to-leading order calculations with MadGraph5_aMC@NLO matched to Herwig++ are presented. Samples with ttcc in the three flavour scheme, in a next-to-leading order matrix element are compared to an inclusive tt sample with the charm contribution coming from the parton shower. The effects of generator-level cuts, the functional form of the renormalization and factorization scales, and the starting scale of the parton shower are investigated.

  20. Manlighet i kris? Några anmärkningar om mansporträtt i tre populärlitterära romaner

    OpenAIRE

    Szymoniak, Katarzyna

    2010-01-01

    I artikeln konfronteras Susan Faludis och Thomas Johanssons teori om manlighetskris med mansporträtt i tre svenska populärlitterära romaner. Teorin om manlighetskris uppstod i samband med feminism. Enligt forskarna visar sig manlighetskrisen i mäns oförmåga att ingå nära relationer, ensamhet och rädsla att inte leva upp till mansidealet. Tre svenska populärromaner Pappadagar i Råttans år av Daniel Möllberg (2007), Vi som aldrig sa hora av Ronnie Sandahl (2007) and Vi har redan sagt hej då av ...

  1. PERFORMANCE

    Directory of Open Access Journals (Sweden)

    M Cilli

    2014-10-01

    Full Text Available This study aimed to investigate the kinematic and kinetic changes when resistance is applied in horizontal and vertical directions, produced by using different percentages of body weight, caused by jumping movements during a dynamic warm-up. The group of subjects consisted of 35 voluntary male athletes (19 basketball and 16 volleyball players; age: 23.4 ± 1.4 years, training experience: 9.6 ± 2.7 years; height: 177.2 ± 5.7 cm, body weight: 69.9 ± 6.9 kg studying Physical Education, who had a jump training background and who were training for 2 hours, on 4 days in a week. A dynamic warm-up protocol containing seven specific resistance movements with specific resistance corresponding to different percentages of body weight (2%, 4%, 6%, 8%, 10% was applied randomly on non consecutive days. Effects of different warm-up protocols were assessed by pre-/post- exercise changes in jump height in the countermovement jump (CMJ and the squat jump (SJ measured using a force platform and changes in hip and knee joint angles at the end of the eccentric phase measured using a video camera. A significant increase in jump height was observed in the dynamic resistance warm-up conducted with different percentages of body weight (p 0.05. In jump movements before and after the warm-up, while no significant difference between the vertical ground reaction forces applied by athletes was observed (p>0.05, in some cases of resistance, a significant reduction was observed in hip and knee joint angles (p<0.05. The dynamic resistance warm-up method was found to cause changes in the kinematics of jumping movements, as well as an increase in jump height values. As a result, dynamic warm-up exercises could be applicable in cases of resistance corresponding to 6-10% of body weight applied in horizontal and vertical directions in order to increase the jump performance acutely.

  2. Introduction and Rollout of a New Group A Meningococcal Conjugate Vaccine (PsA-TT) in African Meningitis Belt Countries, 2010–2014

    Science.gov (United States)

    Djingarey, Mamoudou H.; Diomandé, Fabien V. K.; Barry, Rodrigue; Kandolo, Denis; Shirehwa, Florence; Lingani, Clement; Novak, Ryan T.; Tevi-Benissan, Carol; Perea, William; Preziosi, Marie-Pierre; LaForce, F. Marc

    2015-01-01

    Background. A group A meningococcal conjugate vaccine (PsA-TT) was developed specifically for the African “meningitis belt” and was prequalified by the World Health Organization (WHO) in June 2010. The vaccine was first used widely in Burkina Faso, Mali, and Niger in December 2010 with great success. The remaining 23 meningitis belt countries wished to use this new vaccine. Methods. With the help of African countries, WHO developed a prioritization scheme and used or adapted existing immunization guidelines to mount PsA-TT vaccination campaigns. Vaccine requirements were harmonized with the Serum Institute of India, Ltd. Results. Burkina Faso was the first country to fully immunize its 1- to 29-year-old population in December 2010. Over the next 4 years, vaccine coverage was extended to 217 million Africans living in 15 meningitis belt countries. Conclusions. The new group A meningococcal conjugate vaccine was well received, with country coverage rates ranging from 85% to 95%. The rollout proceeded smoothly because countries at highest risk were immunized first while attention was paid to geographic contiguity to maximize herd protection. Community participation was exemplary. PMID:26553672

  3. Association of neural tube defects in children of mothers with MTHFR 677TT genotype and abnormal carbohydrate metabolism risk: a case-control study.

    Science.gov (United States)

    Cadenas-Benitez, N M; Yanes-Sosa, F; Gonzalez-Meneses, A; Cerrillos, L; Acosta, D; Praena-Fernandez, J M; Neth, O; Gomez de Terreros, I; Ybot-González, P

    2014-03-26

    Abnormalities in maternal folate and carbohydrate metabolism have both been shown to induce neural tube defects (NTD) in humans and animal models. However, the relationship between these two factors in the development of NTDs remains unclear. Data from mothers of children with spina bifida seen at the Unidad de Espina Bífida del Hospital Infantil Virgen del Rocío (case group) were compared to mothers of healthy children with no NTD (control group) who were randomly selected from patients seen at the outpatient ward in the same hospital. There were 25 individuals in the case group and 41 in the control group. Analysis of genotypes for the methylenetetrahydrofolate reductase (MTHFR) 677CT polymorphism in women with or without risk factors for abnormal carbohydrate metabolism revealed that mothers who were homozygous for the MTHFR 677TT polymorphism and at risk of abnormal carbohydrate metabolism were more likely to have offspring with spina bifida and high levels of homocysteine, compared to the control group. The increased incidence of NTDs in mothers homozygous for the MTHFR 677TT polymorphism and at risk of abnormal carbohydrate metabolism stresses the need for careful metabolic screening in pregnant women, and, if necessary, determination of the MTHFR 677CT genotype in those mothers at risk of developing abnormal carbohydrate metabolism.

  4. Measurements of tt̅ differential cross-sections of highly boosted top quarks decaying to all-hadronic final states with ATLAS

    CERN Document Server

    Cormier, Kyle James Read; The ATLAS collaboration

    2018-01-01

    Measurements are made of differential cross-sections of highly boosted pair-produced top quarks as a function of top-quark and tt¯ system kinematic observables using proton--proton collisions at a center-of-mass energy of √s=13 TeV. The data set corresponds to an integrated luminosity of 36.1 fb^{−1}, recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. Events with two large-radius jets in the final state, one with transverse momentum pT>500 GeV and a second with pT>350 GeV, are used for the measurement. The top-quark candidates are separated from the multijet background using jet substructure information and association with a b-tagged jet. The measured spectra are corrected for detector effects to a particle-level fiducial phase space and a parton-level limited phase space, and are compared to several Monte Carlo simulations by means of calculated χ2 values. The cross-section for tt¯ production in the fiducial phase-space region is 292±7 (stat)±76(syst) fb, to be com...

  5. Research of the Higgs boson in dimuon final state and study of the tt-bar production asymmetry with the D0 experiment at the Tevatron

    International Nuclear Information System (INIS)

    Faure, Alexandre

    2014-01-01

    Two high energy particle physics analyses are presented in this PhD report using events with two leptons oppositely charged and with missing transverse energy. These events are selected using 9.7 fb -1 of total pp collisions data collected with the D0 detector at the Tevatron at √s=1.96 TeV. The first analysis is the research of the Higgs boson decaying in the H→W→μvμv channel. No significant excess above the background prediction is observed. Upper limits on Higgs boson production cross-section are computed in the standard model framework but also in the 4. generation of fermions and in the fermiophobic coupling to Higgs boson hypotheses. In order to validate the research methodology, the W boson pair production cross-section is measured. The second analysis is the measurement of the forward-backward asymmetry of the tt pair production. This is the first measurement in the di-leptonic channel at D0 experiment. In this context, a new tt pair kinematic reconstruction is used (matrix element method) to give a raw measurement of the forward-backward asymmetry. Thanks to a dedicated calibration method, we give a final measurement of AFB=18.0 ± 6.0 (stat) ± 3.3 (syst). (author) [fr

  6. TT2014 meeting report on the 12th Transgenic Technology meeting in Edinburgh: new era of transgenic technologies with programmable nucleases in the foreground.

    Science.gov (United States)

    Beck, Inken M; Sedlacek, Radislav

    2015-02-01

    The 12th Transgenic Technology meeting was held in Edinburgh on 6th-8th October 2014 and interest to participate in the meeting overcame all expectations. The TT2014 was the largest meeting ever with more than 540 scientists, technicians, and students from all over the world. The meeting had an excellent scientific program that brought information on the latest ground-breaking technologies for gene targeting and genome editing using programmable nucleases into the foreground. These presentations were well balanced with several highlights over viewing topics in embryonic stem cell research, embryogenesis, disease models, and animals in agriculture. Ample space was reserved also for short talks presenting technical development and for highlighting posters contributions. A highlight of the meeting was the award of the 10th International Society of Transgenic Technologies Prize to Janet Rossant for her outstanding contributions in the field of mouse embryogenesis.

  7. Measurement of colour flow with the jet pull angle in tt¯ events using the ATLAS detector at s=8 TeV

    Directory of Open Access Journals (Sweden)

    G. Aad

    2015-11-01

    Full Text Available The distribution and orientation of energy inside jets is predicted to be an experimental handle on colour connections between the hard-scatter quarks and gluons initiating the jets. This Letter presents a measurement of the distribution of one such variable, the jet pull angle. The pull angle is measured for jets produced in tt¯ events with one W boson decaying leptonically and the other decaying to jets using 20.3 fb−1 of data recorded with the ATLAS detector at a centre-of-mass energy of s=8 TeV at the LHC. The jet pull angle distribution is corrected for detector resolution and acceptance effects and is compared to various models.

  8. Procedure guide for the implementation of quality management program in products and services link with the utilization of tracers technology (TT) and Nucleonic Control System

    International Nuclear Information System (INIS)

    Resnizky, S.; Banados Perez, H.; Longo, G.; Rodriguez Cardona, R.L.; Sebastian Calvo, C.; Kohnenkamp O, I.; Duran P, O.

    2000-01-01

    This Manual was elaborated in the mark of the project RLA/8/024 ARCAL XLII 'Industrial Applications of the Tracer Technology and Nucleonic Control Systems'. The objective of the present Quality Manual is to spread the Quality Policy and to describe the form of implementing the Quality Management System, according to the requirements of the Standard ISO 9001:2000. It is applied to the design, development, implementation and maintenance of the products of the Organization of Tracers Technology (TT) and Nucleonic Control Systems (SCN). It have 9 Section: I. Introduction, II. Normative references, III. Definitions, IV. Quality Management System; V. Direction Responsibility; VI. Resources Management; VII. Products Accomplishment; VIII. Measurement, Analysis and Improvement and 7 Annex

  9. Initial mechanisms for the decomposition of electronically excited energetic materials: 1,5′-BT, 5,5′-BT, and AzTT

    International Nuclear Information System (INIS)

    Yuan, Bing; Yu, Zijun; Bernstein, Elliot R.

    2015-01-01

    Decomposition of nitrogen-rich energetic materials 1,5′-BT, 5,5′-BT, and AzTT (1,5′-Bistetrazole, 5,5′-Bistetrazole, and 5-(5-azido-(1 or 4)H-1,2,4-triazol-3-yl)tetrazole, respectively), following electronic state excitation, is investigated both experimentally and theoretically. The N 2 molecule is observed as an initial decomposition product from the three materials, subsequent to UV excitation, with a cold rotational temperature (<30 K). Initial decomposition mechanisms for these three electronically excited materials are explored at the complete active space self-consistent field (CASSCF) level. Potential energy surface calculations at the CASSCF(12,8)/6-31G(d) level illustrate that conical intersections play an essential role in the decomposition mechanism. Electronically excited S 1 molecules can non-adiabatically relax to their ground electronic states through (S 1 /S 0 ) CI conical intersections. 1,5′-BT and 5,5′-BT materials have several (S 1 /S 0 ) CI conical intersections between S 1 and S 0 states, related to different tetrazole ring opening positions, all of which lead to N 2 product formation. The N 2 product for AzTT is formed primarily by N–N bond rupture of the –N 3 group. The observed rotational energy distributions for the N 2 products are consistent with the final structures of the respective transition states for each molecule on its S 0 potential energy surface. The theoretically derived vibrational temperature of the N 2 product is high, which is similar to that found for energetic salts and molecules studied previously

  10. Effects of TT8 and HB12 Silencing on the Relations between the Molecular Structures of Alfalfa ( Medicago sativa) Plants and Their Nutritional Profiles and In Vitro Gas Production.

    Science.gov (United States)

    Lei, Yaogeng; Hannoufa, Abdelali; Prates, Luciana Louzada; Shi, Haitao; Wang, Yuxi; Biligetu, Bill; Christensen, David; Yu, Peiqiang

    2018-06-06

    The objective of this study was to investigate the effects of silencing the TT8 and HB12 genes on the nutritive profiles and in vitro gas production of alfalfa in relation to the spectral molecular structures of alfalfa. TT8-silenced (TT8i, n = 5) and HB12-silenced (HB12i, n = 11) alfalfa were generated by RNA interference (RNAi) and grown with nontransgenic wild type controls (WT, n = 4) in a greenhouse. Alfalfa plants were harvested at early-to-mid vegetative stage. Samples were analyzed for their chemical compositions, CNCPS fractions, and in vitro gas production. Correlations and regressions of the nutritional profiles and in vitro gas production with the molecular spectral structures were also determined. The results showed that the transformed alfalfa had higher digestible fiber and lower crude protein with higher proportions of indigestible protein than WT. HB12 RNAi had lower gas production compared with those of the others. Some chemical, CNCPS, and gas-production profiles were closely correlated with spectral structures and could be well predicted from spectral parameters. In conclusion, the RNAi silencing of TT8 and HB12 in alfalfa altered the chemical, CNCPS and gas-production profiles of alfalfa, and such alterations were closely correlated with the inherent spectral structures of alfalfa.

  11. Choline Intake, Plasma Riboflavin, and the Phosphatidylethanolamine N-Methyltransferase G5465A Genotype Predict Plasma Homocysteine in Folate-Deplete Mexican-American Men with the Methylenetetrahydrofolate Reductase 677TT Genotype

    NARCIS (Netherlands)

    Caudill, M.A.; Dellschaft, N.; Solis, C.; Hinkis, S.; Ivanov, A.A.; Nash-Barboza, S.; Randall, K.E.; Jackson, B.; Solomita, G.N.; Vermeylen, F.

    2009-01-01

    We previously showed that provision of the folate recommended dietary allowance and either 300, 550, 1100, or 2200 mg/d choline for 12 wk resulted in diminished folate status and a tripling of plasma total homocysteine (tHcy) in men with the methylenetetrahydrofolate reductase (MTHFR) 677TT

  12. Structure-composition sensitivity in 'Metallic' Zintl phases: A study of Eu(Ga1-xTtx)2 (Tt=Si, Ge, 0≤x≤1)

    International Nuclear Information System (INIS)

    You, Tae-Soo; Zhao Jingtai; Poettgen, Rainer; Schnelle, Walter; Burkhardt, Ulrich; Grin, Yuri; Miller, Gordon J.

    2009-01-01

    Two isoelectronic series, Eu(Ga 1-x Tt x ) 2 (Tt=Si, Ge, 0≤x≤1), have been synthesized and characterized by powder and single-crystal X-ray diffraction, physical property measurements, and electronic structure calculations. In Eu(Ga 1-x Si x ) 2 , crystal structures vary from the KHg 2 -type to the AlB 2 -type, and, finally, the ThSi 2 -type structure as x increases. The hexagonal AlB 2 -type structure is identified for compositions 0.18(2)≤x 3 nets. As smaller Si atoms replace Ga atoms while the number of valence electrons increases, the lattice parameters, unit cell volumes, and Ga-Si distances in this phase region decrease significantly. Although aspects of X-ray diffraction results suggest puckering of the 6 3 nets for the Si-richest example of the AlB 2 -type Eu(Ga 1-x Si x ) 2 , the complete experimental evidence remains inconclusive. On the other hand, in Eu(Ga 1-x Ge x ) 2 , six different structural types were observed as x varies. In addition to EuGa 2 (KHg 2 -type; space group Imma) and EuGe 2 (own structure type, space group P3-barm1), the ternary phases studied show four different structures: the AlB 2 -type for Ga-rich compositions; the YPtAs-type structure for EuGaGe; and two new structures, which are intergrowths of the YPtAs-type EuGaGe and EuGe 2 , for Ge-rich compositions. These two Ge-rich phases include: (1) Eu(Ga 0.45(2) Ge 0.55(2) ) 2 containing two YPtAs-type motifs of EuGaGe plus one EuGe 2 motif; and (2) Eu(Ga 0.40(2) Ge 0.60(2) ) 2 containing one YPtAs-type motif alternating with a split site at x=2/3 ,y=1/3 and z=0.4798(2) with ca. 50% site occupancy by Ga and Ge along the c-axis. Magnetic susceptibilities of three Eu(Ga 1-x Ge x ) 2 compounds display Curie-Weiss behavior above ca. 100 K, and show effective magnetic moments indicative of divalent Eu with a 4f 7 electronic configuration, consistent with. X-ray absorption spectra (XAS). Density of states (DOS) and crystal orbital Hamilton population (COHP) analyses, based on first

  13. Individual and combined effects of ApoE and MTHFR 677C/T polymorphisms on cognitive performance in Spanish adolescents: the AVENA study.

    Science.gov (United States)

    Ruiz, Jonatan R; Castillo, Ruth; Labayen, Idoia; Moreno, Luis A; Fuentes, Miguel García; Lamuño, Domingo González; Alvarez Granda, Jesus L; Lucia, Alejandro; Ortega, Francisco B

    2010-06-01

    To examine the individual and combined associations of ApoE and MTHFR 677C/T polymorphisms with cognitive performance in adolescents. The study comprised 412 Spanish adolescents (13 to 18.5 years of age). Cognitive performance (verbal, numeric and reasoning abilities, and an overall score) was measured by the Spanish-version of the SRA-Test of Educational-Ability. We observed no differences in the cognitive performance study variables in adolescents carrying or not carrying the ApoE epsilon4 variant. Adolescents without the MTHFR 677TT genotype had significantly better cognitive performance than their TT peers. The analysis of the combined effect of these polymorphisms revealed that those individuals carrying both the ApoE epsilon4 variant and the MTHFR 677TT genotype had significantly worse cognitive performance than their peers with other genotype combinations. These findings were independent of sex, age pubertal status, socioeconomic status, physical activity, and skipping breakfast. The results of the present study suggest that the ApoE epsilon4 alone is not associated with cognitive performance in adolescents. Individuals with the MTHFR 677TT genotype had slightly impaired cognitive performance, whereas we observed a combined effect of both the ApoE epsilon4 variant and the MTHFR 677TT genotype on cognitive performance. More research is needed in larger population samples to corroborate our findings. Copyright 2010 Mosby, Inc. All rights reserved.

  14. A search for the ttH (H → bb) channel at the Large Hadron Collider with the ATLAS detector using a matrix element method

    CERN Document Server

    Basye, Austin Thomas

    A matrix element method analysis of the Standard Model Higgs boson, produced in association with two top quarks decaying to the lepton-plus-jets channel is presented. Based on 20.3 fb−1 of √s=8 TeV data, produced at the Large Hadron Collider and collected by the ATLAS detector, this analysis utilizes multiple advanced techniques to search for tt ̄H signatures with a 125 GeV Higgs boson decaying to two b-quarks. After categorizing selected events based on their jet and b-tag multiplicities, signal rich regions are analyzed using the matrix element method. Resulting variables are then propagated to two parallel multivariate analyses utilizing Neural Networks and Boosted Decision Trees respectively. As no significant excess is found, an observed (expected) limit of 3.4 (2.2) times the Standard Model cross-section is determined at 95% confidence, using the CLs method, for the Neural Network analysis. For the Boosted Decision Tree analysis, an observed (expected) limit of 5.2 (2.7) times the Standard Model cr...

  15. Commissioning of the Atlas pixel detector and search of the Higgs boson in the tt-H, H → bb- channel with the Atlas experiment at the LHC

    International Nuclear Information System (INIS)

    Aad, G.

    2009-09-01

    The global fit of Higgs boson quantum contributions to the electroweak experimental observables, computed within the Standard Model, favors a light Higgs boson with a mass of m H = 90 -27 +36 GeV, on the edge of the 95% Confidence Level region excluded by LEP. Finding a light Higgs boson at LHC is experimentally difficult and several channels with various signatures will be sought for. The associated production of the Higgs boson with a pair of top quarks, with the subsequent decay of the Higgs boson into b-quark pairs (dominant for m H <135 GeV), is one of the channels considered. This channel opens the possibility of measuring the top and b-quark Yukawa couplings. The potential of the ATLAS detector to observe this channel is described. Several ingredients are crucial: the reconstruction of the top-anti-top system with a high-purity, excellent b-tagging capabilities and good knowledge of the tt-bar+jets background. The pixel detector is the most important ATLAS sub-detectors for tagging b -jets. The ATLAS detector was commissioned with cosmic muon rays in autumn 2008. The pixel detector dead channels, calibration constants and slow control informations are described for this period. A detailed study about pixel noise determination and suppression is presented. Finally, the pixel detection efficiency is measured using cosmic muon rays. (author)

  16. On the search for new anticancer drugs 14: the plasma pharmacokinetics and tissue distribution of spin-labeled thio-TEPA (SL-O-TT).

    Science.gov (United States)

    Gutierrez, P L; Cohen, B E; Sosnovsky, G; Davis, T A; Egorin, M J

    1985-01-01

    We defined the plasma and tissue concentrations and pharmacokinetics of SL-O-TT, a spin-labeled analog of thio-TEPA, in 35-44-g male Swiss Webster mice that had received spin-labeled thio-TEPA at a dosage of 10 mg/kg. Concentrations of spin-labeled thio-TEPA in ethyl acetate extracts of tissue and plasma were determined by gas-liquid chromatography and electron spin resonance spectroscopy. Plasma concentrations of spin-labeled thio-TEPA declined in a biexponential fashion that was well described by the equation: Ct = 21.5e-0.276t + 2.30e-0.026t indicating a half-life alpha of 2.5 min and a half-life beta of 26.6 min. After 2 h there was still spin-labeled thio-TE-PA in plasma, but not in tissues. In tissues, no spin-labeled thio-TEPA was detected with gas-liquid chromatography 15 min after injection, but with electron-spin resonance label was found in lung and skeletal muscle. The main metabolite of spin-labeled thio-TEPA is spin-labeled TEPA, where oxidative desulfurization is invoked as the main metabolic mechanism. Reduction of the spin label to the hydroxylamine was also observed with time.

  17. Procedure guide for the implementation of quality management program in products and services link with the utilization of tracers technology (TT) and Nucleonic Control System; Informe de la reunion de expertos para la elaboracion de un modelo del Sistema de Gestion de la Calidad para la utilizacion de TT y SCN

    Energy Technology Data Exchange (ETDEWEB)

    Resnizky, S [Comision Nacional de Energia Atomica (CNEA), Buenos Aires (Argentina); Banados Perez, H [Instituto de Pesquizas Energia Nuclear, Sao Paulo (Brazil); Longo, G [A-Z Treinamiento Empresarial SC Ltda., Sao Paulo (Brazil); Rodriguez Cardona, R L [Agencia de Energia Nuclear, La Habana (Cuba); Sebastian Calvo, C [Instituto Peruano de Energia Nuclear, Lima (Peru); Kohnenkamp O, I [Comision Chilena de Energia Nuclear, La Reina (Chile); Duran P, O [Comision Chilena de Energia Nuclear, La Reina (Chile)

    2000-10-06

    This Manual was elaborated in the mark of the project RLA/8/024 ARCAL XLII 'Industrial Applications of the Tracer Technology and Nucleonic Control Systems'. The objective of the present Quality Manual is to spread the Quality Policy and to describe the form of implementing the Quality Management System, according to the requirements of the Standard ISO 9001:2000. It is applied to the design, development, implementation and maintenance of the products of the Organization of Tracers Technology (TT) and Nucleonic Control Systems (SCN). It have 9 Section: I. Introduction, II. Normative references, III. Definitions, IV. Quality Management System; V. Direction Responsibility; VI. Resources Management; VII. Products Accomplishment; VIII. Measurement, Analysis and Improvement and 7 Annex.

  18. SAMe-TT2R2 Score in the Outpatient Anticoagulation Clinic to Predict Time in Therapeutic Range and Adverse Events.

    Science.gov (United States)

    Pivatto Junior, Fernando; Scheffel, Rafael Selbach; Ries, Lucas; Wolkind, Ricardo Roitman; Marobin, Roberta; Barkan, Sabrina Sigal; Amon, Luís Carlos; Biolo, Andréia

    2017-04-01

    The SAMe-TT2R2 score was developed to predict which patients on oral anticoagulation with vitamin K antagonists (VKAs) will reach an adequate time in therapeutic range (TTR) (> 65%-70%). Studies have reported a relationship between this score and the occurrence of adverse events. To describe the TTR according to the score, in addition to relating the score obtained with the occurrence of adverse events in patients with nonvalvular atrial fibrillation (AF) on oral anticoagulation with VKAs. Retrospective cohort study including patients with nonvalvular AF attending an outpatient anticoagulation clinic of a tertiary hospital. Visits to the outpatient clinic and emergency, as well as hospital admissions to the institution, during 2014 were evaluated. The TTR was calculated through the Rosendaal´s method. We analyzed 263 patients (median TTR, 62.5%). The low-risk group (score 0-1) had a better median TTR as compared with the high-risk group (score ≥ 2): 69.2% vs. 56.3%, p = 0.002. Similarly, the percentage of patients with TTR ≥ 60%, 65% or 70% was higher in the low-risk group (p vitamina K (AVKs) atingirão um tempo na faixa terapêutica (TFT) adequado (> 65%-70%) no seguimento. Estudos também o relacionaram com a ocorrência de eventos adversos. Descrever o TFT de acordo com o escore, além de relacionar a pontuação obtida com a ocorrência de eventos adversos adversos em pacientes com fibrilação atrial (FA) não valvar em anticoagulação oral com AVKs. Estudo de coorte retrospectivo incluindo pacientes com FA não valvar em acompanhamento em ambulatório de anticoagulação de um hospital terciário. Foi realizada uma avaliação retrospectiva de consultas ambulatoriais, visitas a emergência e internações hospitalares na instituição no período de janeiro-dezembro/2014. O TFT foi calculado aplicando-se o método de Rosendaal. Foram analisados 263 pacientes com TFT mediano de 62,5%. O grupo de baixo risco (0-1 ponto) obteve um TFT mediano maior em

  19. Measurement of the tt¯ production cross section in pp¯ collisions at s=1.96TeV using kinematic characteristics of lepton+jets events

    Science.gov (United States)

    Abazov, V. M.; Abbott, B.; Abolins, M.; Acharya, B. S.; Adams, M.; Adams, T.; Aguilo, E.; Ahn, S. H.; Ahsan, M.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Alverson, G.; Alves, G. A.; Anastasoaie, M.; Ancu, L. S.; Andeen, T.; Anderson, S.; Andrieu, B.; Anzelc, M. S.; Arnoud, Y.; Arov, M.; Arthaud, M.; Askew, A.; Åsman, B.; Assis Jesus, A. C. S.; Atramentov, O.; Autermann, C.; Avila, C.; Ay, C.; Badaud, F.; Baden, A.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Banerjee, P.; Barberis, E.; Barfuss, A.-F.; Bargassa, P.; Baringer, P.; Barreto, J.; Bartlett, J. F.; Bassler, U.; Bauer, D.; Beale, S.; Bean, A.; Begalli, M.; Begel, M.; Belanger-Champagne, C.; Bellantoni, L.; Bellavance, A.; Benitez, J. A.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Berntzon, L.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bezzubov, V. A.; Bhat, P. C.; Bhatnagar, V.; Biscarat, C.; Blazey, G.; Blekman, F.; Blessing, S.; Bloch, D.; Bloom, K.; Boehnlein, A.; Boline, D.; Bolton, T. A.; Borissov, G.; Bos, K.; Bose, T.; Brandt, A.; Brock, R.; Brooijmans, G.; Bross, A.; Brown, D.; Buchanan, N. J.; Buchholz, D.; Buehler, M.; Buescher, V.; Burdin, S.; Burke, S.; Burnett, T. H.; Buszello, C. P.; Butler, J. M.; Calfayan, P.; Calvet, S.; Cammin, J.; Caron, S.; Carvalho, W.; Casey, B. C. K.; Cason, N. M.; Castilla-Valdez, H.; Chakrabarti, S.; Chakraborty, D.; Chan, K. M.; Chan, K.; Chandra, A.; Charles, F.; Cheu, E.; Chevallier, F.; Cho, D. K.; Choi, S.; Choudhary, B.; Christofek, L.; Christoudias, T.; Cihangir, S.; Claes, D.; Clément, C.; Clément, B.; Coadou, Y.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M.-C.; Crépé-Renaudin, S.; Cutts, D.; Ćwiok, M.; da Motta, H.; Das, A.; Davies, G.; de, K.; de Jong, S. J.; de Jong, P.; de La Cruz-Burelo, E.; de Oliveira Martins, C.; Degenhardt, J. D.; Déliot, F.; Demarteau, M.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Diehl, H. T.; Diesburg, M.; Dominguez, A.; Dong, H.; Dudko, L. V.; Duflot, L.; Dugad, S. R.; Duggan, D.; Duperrin, A.; Dyer, J.; Dyshkant, A.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Eno, S.; Ermolov, P.; Evans, H.; Evdokimov, A.; Evdokimov, V. N.; Ferapontov, A. V.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Ford, M.; Fortner, M.; Fox, H.; Fu, S.; Fuess, S.; Gadfort, T.; Galea, C. F.; Gallas, E.; Galyaev, E.; Garcia, C.; Garcia-Bellido, A.; Gavrilov, V.; Gay, P.; Geist, W.; Gelé, D.; Gerber, C. E.; Gershtein, Y.; Gillberg, D.; Ginther, G.; Gollub, N.; Gómez, B.; Goussiou, A.; Grannis, P. D.; Greenlee, H.; Greenwood, Z. D.; Gregores, E. M.; Grenier, G.; Gris, Ph.; Grivaz, J.-F.; Grohsjean, A.; Grünendahl, S.; Grünewald, M. W.; Guo, J.; Guo, F.; Gutierrez, P.; Gutierrez, G.; Haas, A.; Hadley, N. J.; Haefner, P.; Hagopian, S.; Haley, J.; Hall, I.; Hall, R. E.; Han, L.; Hanagaki, K.; Hansson, P.; Harder, K.; Harel, A.; Harrington, R.; Hauptman, J. M.; Hauser, R.; Hays, J.; Hebbeker, T.; Hedin, D.; Hegeman, J. G.; Heinmiller, J. M.; Heinson, A. P.; Heintz, U.; Hensel, C.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hobbs, J. D.; Hoeneisen, B.; Hoeth, H.; Hohlfeld, M.; Hong, S. J.; Hooper, R.; Hossain, S.; Houben, P.; Hu, Y.; Hubacek, Z.; Hynek, V.; Iashvili, I.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffré, M.; Jain, S.; Jakobs, K.; Jarvis, C.; Jesik, R.; Johns, K.; Johnson, C.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Juste, A.; Käfer, D.; Kahn, S.; Kajfasz, E.; Kalinin, A. M.; Kalk, J. R.; Kalk, J. M.; Kappler, S.; Karmanov, D.; Kasper, J.; Kasper, P.; Katsanos, I.; Kau, D.; Kaur, R.; Kaushik, V.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. M.; Khatidze, D.; Kim, H.; Kim, T. J.; Kirby, M. H.; Kirsch, M.; Klima, B.; Kohli, J. M.; Konrath, J.-P.; Kopal, M.; Korablev, V. M.; Kothari, B.; Kozelov, A. V.; Krop, D.; Kryemadhi, A.; Kuhl, T.; Kumar, A.; Kunori, S.; Kupco, A.; Kurča, T.; Kvita, J.; Lacroix, F.; Lam, D.; Lammers, S.; Landsberg, G.; Lazoflores, J.; Lebrun, P.; Lee, W. M.; Leflat, A.; Lehner, F.; Lellouch, J.; Lesne, V.; Leveque, J.; Lewis, P.; Li, J.; Li, Q. Z.; Li, L.; Lietti, S. M.; Lima, J. G. R.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, Y.; Liu, Z.; Lobo, L.; Lobodenko, A.; Lokajicek, M.; Lounis, A.; Love, P.; Lubatti, H. J.; Lyon, A. L.; Maciel, A. K. A.; Mackin, D.; Madaras, R. J.; Mättig, P.; Magass, C.; Magerkurth, A.; Makovec, N.; Mal, P. K.; Malbouisson, H. B.; Malik, S.; Malyshev, V. L.; Mao, H. S.; Maravin, Y.; Martin, B.; McCarthy, R.; Melnitchouk, A.; Mendes, A.; Mendoza, L.; Mercadante, P. G.; Merkin, M.; Merritt, K. W.; Meyer, J.; Meyer, A.; Michaut, M.; Millet, T.; Mitrevski, J.; Molina, J.; Mommsen, R. K.; Mondal, N. K.; Moore, R. W.; Moulik, T.; Muanza, G. S.; Mulders, M.; Mulhearn, M.; Mundal, O.; Mundim, L.; Nagy, E.; Naimuddin, M.; Narain, M.; Naumann, N. A.; Neal, H. A.; Negret, J. P.; Neustroev, P.; Nilsen, H.; Nomerotski, A.; Novaes, S. F.; Nunnemann, T.; O'Dell, V.; O'Neil, D. C.; Obrant, G.; Ochando, C.; Onoprienko, D.; Oshima, N.; Osta, J.; Otec, R.; Otero Y Garzón, G. J.; Owen, M.; Padley, P.; Pangilinan, M.; Parashar, N.; Park, S.-J.; Park, S. K.; Parsons, J.; Partridge, R.; Parua, N.; Patwa, A.; Pawloski, G.; Penning, B.; Perea, P. M.; Peters, K.; Peters, Y.; Pétroff, P.; Petteni, M.; Piegaia, R.; Piper, J.; Pleier, M.-A.; Podesta-Lerma, P. L. M.; Podstavkov, V. M.; Pogorelov, Y.; Pol, M.-E.; Polozov, P.; Pompo, A.; Pope, B. G.; Popov, A. V.; Potter, C.; Prado da Silva, W. L.; Prosper, H. B.; Protopopescu, S.; Qian, J.; Quadt, A.; Quinn, B.; Rakitine, A.; Rangel, M. S.; Rani, K. J.; Ranjan, K.; Ratoff, P. N.; Renkel, P.; Reucroft, S.; Rich, P.; Rijssenbeek, M.; Ripp-Baudot, I.; Rizatdinova, F.; Robinson, S.; Rodrigues, R. F.; Royon, C.; Rubinov, P.; Ruchti, R.; Safronov, G.; Sajot, G.; Sánchez-Hernández, A.; Sanders, M. P.; Santoro, A.; Savage, G.; Sawyer, L.; Scanlon, T.; Schaile, D.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schieferdecker, P.; Schliephake, T.; Schmitt, C.; Schwanenberger, C.; Schwartzman, A.; Schwienhorst, R.; Sekaric, J.; Sengupta, S.; Severini, H.; Shabalina, E.; Shamim, M.; Shary, V.; Shchukin, A. A.; Shivpuri, R. K.; Shpakov, D.; Siccardi, V.; Simak, V.; Sirotenko, V.; Skubic, P.; Slattery, P.; Smirnov, D.; Smith, R. P.; Snow, J.; Snow, G. R.; Snyder, S.; Söldner-Rembold, S.; Sonnenschein, L.; Sopczak, A.; Sosebee, M.; Soustruznik, K.; Souza, M.; Spurlock, B.; Stark, J.; Steele, J.; Stolin, V.; Stone, A.; Stoyanova, D. A.; Strandberg, J.; Strandberg, S.; Strang, M. A.; Strauss, M.; Strauss, E.; Ströhmer, R.; Strom, D.; Strovink, M.; Stutte, L.; Sumowidagdo, S.; Svoisky, P.; Sznajder, A.; Talby, M.; Tamburello, P.; Tanasijczuk, A.; Taylor, W.; Telford, P.; Temple, J.; Tiller, B.; Tissandier, F.; Titov, M.; Tokmenin, V. V.; Tomoto, M.; Toole, T.; Torchiani, I.; Trefzger, T.; Tsybychev, D.; Tuchming, B.; Tully, C.; Tuts, P. M.; Unalan, R.; Uvarov, S.; Uvarov, L.; Uzunyan, S.; Vachon, B.; van den Berg, P. J.; van Eijk, B.; van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vartapetian, A.; Vasilyev, I. A.; Vaupel, M.; Verdier, P.; Vertogradov, L. S.; Verzocchi, M.; Villeneuve-Seguier, F.; Vint, P.; Vlimant, J.-R.; Vokac, P.; von Toerne, E.; Voutilainen, M.; Vreeswijk, M.; Wagner, R.; Wahl, H. D.; Wang, L.; Wang, M. H. L. S.; Warchol, J.; Watts, G.; Wayne, M.; Weber, M.; Weber, G.; Weerts, H.; Wenger, A.; Wermes, N.; Wetstein, M.; White, A.; Wicke, D.; Wilson, G. W.; Wimpenny, S. J.; Wobisch, M.; Wood, D. R.; Wyatt, T. R.; Xie, Y.; Yacoob, S.; Yamada, R.; Yan, M.; Yasuda, T.; Yatsunenko, Y. A.; Yip, K.; Yoo, H. D.; Youn, S. W.; Yu, J.; Yu, C.; Yurkewicz, A.; Zatserklyaniy, A.; Zeitnitz, C.; Zhang, D.; Zhao, T.; Zhou, B.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zieminski, A.; Zivkovic, L.; Zutshi, V.; Zverev, E. G.

    2007-11-01

    We present a measurement of the top quark pair production cross section in pp¯ collisions at s=1.96TeV utilizing 425pb-1 of data collected with the D0 detector at the Fermilab Tevatron Collider. We consider the final state of the top quark pair containing one high-pT electron or muon and at least four jets. We exploit specific kinematic features of tt¯ events to extract the cross section. For a top quark mass of 175 GeV, we measure σtt¯=6.4-1.2+1.3(stat)±0.7(syst)±0.4(lum)pb, in good agreement with the standard model prediction.

  20. Distribuição volumétrica de pontas de pulverização Turbo Teejet 11002 em diferentes condições operacionais Distribution pattern of nozzle TT 11002 under different operational conditions

    Directory of Open Access Journals (Sweden)

    F.C.L. Freitas

    2005-03-01

    Full Text Available Este trabalho teve como objetivo determinar a uniformidade de distribuição para a ponta de pulverização TT 11002 em função de espaçamento entre bicos, altura de barra e pressão de trabalho, bem como avaliar a possibilidade de redução do volume de calda por meio da alteração do espaçamento entre bicos. Foram avaliados os perfis de distribuição de pontas TT 11002, para as alturas de 30, 40 e 50 cm, nas pressões de 100, 200, 300 e 400 kPa. A determinação foi realizada em mesa de teste para pontas de pulverização hidráulica, composta por canaletas em "V", espaçadas de 5 cm. Foram utilizadas, para cada configuração, 10 unidades de pontas TT 11002, instaladas isoladamente no centro da mesa. Em seguida, procedeu-se à coleta e à medição do volume pulverizado por 60 segundos e determinou-se o perfil de distribuição. A partir do perfil de distribuição em cada uma das configurações estudadas, simulou-se, utilizando programa computacional, a deposição ao longo da barra de pulverização para bicos espaçados de 40, 50, 80, 100, 120 e 150 cm. A uniformidade de distribuição foi avaliada pelo coeficiente de variação (CV, em uma barra de 12 metros de largura, onde foram utilizados os dados dos seis metros centrais. A ponta de pulverização TT 11002 apresentou boa uniformidade de distribuição (CV inferior a 7%, na pressão de 100 kPa, para bicos espaçados até 50 cm e nas alturas de barra de 40 e 50 cm. Nas pressões acima de 200 kPa, boa uniformidade de distribuição foi verificada para espaçamentos de até 50, 100 e 120 cm, para as alturas de barra de 30, 40 e 50 cm, respectivamente. A ponta TT 11002 possibilita redução de volume de calda com o aumento do espaçamento entre bicos, mantendo boa uniformidade de distribuição com maior capacidade operacional do equipamento de aplicação.This work aimed to evaluate spray distribution uniformity for nozzle TT 11002 using varying nozzle spacing, spray height and

  1. Prolonged self-paced exercise in the heat - environmental factors affecting performance

    DEFF Research Database (Denmark)

    Junge, Nicklas; Jørgensen, Rasmus; Flouris, Andreas D

    2016-01-01

    ) was on average reduced by 15% in the 14 studies that fulfilled the inclusion criteria. Ambient temperature per se was a poor predictor of the integrated environmental heat stress and 2 of the prevailing heat stress indices (WBGT and UTCI) failed to predict the environmental influence on performance. The weighing......In this review we examine how self-paced performance is affected by environmental heat stress factors during cycling time trial performance as well as considering the effects of exercise mode and heat acclimatization. Mean power output during prolonged cycling time trials in the heat (≥30°C...... of wind speed appears to be too low for predicting the effect for cycling in trained acclimatized subjects, where performance may be maintained in outdoor time trials at ambient temperatures as high as 36°C (36°C UTCI; 28°C WBGT). Power output during indoor trials may also be maintained with temperatures...

  2. Measurements of fiducial cross-sections for tt{sup -bar} production with one or two additional b-jets in pp collisions at √s=8 TeV using the ATLAS detector

    Energy Technology Data Exchange (ETDEWEB)

    Aad, G. [CPPM, Aix-Marseille Université and CNRS/IN2P3, Marseille (France); Abbott, B. [Homer L. Dodge Department of Physics and Astronomy, University of Oklahoma, Norman, OK (United States); Abdallah, J. [Institute of Physics, Academia Sinica, Taipei, Taiwan (China); Abdinov, O. [Institute of Physics, Azerbaijan Academy of Sciences, Baku (Azerbaijan); Aben, R. [Nikhef National Institute for Subatomic Physics and University of Amsterdam, Amsterdam (Netherlands); and others

    2016-01-07

    Fiducial cross-sections for tt{sup -bar} production with one or two additional b-jets are reported, using an integrated luminosity of 20.3 fb{sup -1} of proton–proton collisions at a centre-of-mass energy of 8 TeV at the Large Hadron Collider, collected with the ATLAS detector. The cross-section times branching ratio for tt{sup -bar} events with at least one additional b-jet is measured to be 950 ± 70 (stat.) {sub -190}{sup +240} (syst.) fb in the lepton-plus-jets channel and 50 ± 10 (stat.) {sub -10}{sup +15} (syst.) fb in the eμ channel. The cross-section times branching ratio for events with at least two additional b-jets is measured to be 19.3 ± 3.5 (stat.) ± 5.7 (syst.) fb in the dilepton channel (eμ, μμ, and ee) using a method based on tight selection criteria, and 13.5 ± 3.3 (stat.) ± 3.6 (syst.) fb using a looser selection that allows the background normalisation to be extracted from data. The latter method also measures a value of 1.30 ± 0.33 (stat.) ± 0.28 (syst.)% for the ratio of tt{sup -bar} production with two additional b-jets to tt{sup -bar} production with any two additional jets. All measurements are in good agreement with recent theory predictions.

  3. Measurement of the tt¯ production cross-section using eμ events with b-tagged jets in pp collisions at s=13TeV with the ATLAS detector

    Directory of Open Access Journals (Sweden)

    M. Aaboud

    2016-10-01

    Full Text Available This paper describes a measurement of the inclusive top quark pair production cross-section (σtt¯ with a data sample of 3.2fb−1 of proton–proton collisions at a centre-of-mass energy of s=13TeV, collected in 2015 by the ATLAS detector at the LHC. This measurement uses events with an opposite-charge electron–muon pair in the final state. Jets containing b-quarks are tagged using an algorithm based on track impact parameters and reconstructed secondary vertices. The numbers of events with exactly one and exactly two b-tagged jets are counted and used to determine simultaneously σtt¯ and the efficiency to reconstruct and b-tag a jet from a top quark decay, thereby minimising the associated systematic uncertainties. The cross-section is measured to be: σtt¯=818±8(stat±27(syst±19(lumi±12(beam pb, where the four uncertainties arise from data statistics, experimental and theoretical systematic effects, the integrated luminosity and the LHC beam energy, giving a total relative uncertainty of 4.4%. The result is consistent with theoretical QCD calculations at next-to-next-to-leading order. A fiducial measurement corresponding to the experimental acceptance of the leptons is also presented.

  4. W boson helicity measurement in tt̄ di-electron channel with the CMS detector at the LHC and the CMS outer tracker upgrade for the HL-LHC

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00346024

    This thesis presents a measurement of the W boson helicity fractions in the tt̄ di-electron final state. The top pair events are produced in proton-proton collisions at a center-of-mass energy of 8 TeV, collected by the CMS experiment at the Large Hadron Collider (LHC), corresponding to an integrated luminosity of 19.7 fb −1 . Only events with two energetic opposite-sign electrons, at least two b-tagged jets and large missing transverse energy in the final state, are considered as di-electron tt̄ signal. The tt̄ event is fully reconstructed using the Analytical Matrix Weighting Technique (AMWT). The helicity fractions of the W boson are estimated from the cos θl∗ distribution using an event-by-event re-weighting technique. Within the quoted statistic and systematic uncertainties, the results are in good agreement with the Standard Model prediction at the 95% confidence level. The results are also consistent with other W boson polarization measurements in the CMS and the ATLAS experiments. While the W ...

  5. Mass spectrometric imaging as a high-spatial resolution tool for functional genomics: Tissue-specific gene expression of TT7 inferred from heterogeneous distribution of metabolites in Arabidopsis flowers

    Energy Technology Data Exchange (ETDEWEB)

    Korte, Andrew R.; Song, Zhihong; Nikolau, Basil J.; Lee, Young Jin

    2011-12-23

    Laser desorption/ionization (LDI) mass spectrometry imaging (MSI) was used to acquire chemical images of flavonoid metabolites on the surface of wild-type and mutant (tt7) Arabidopsis thaliana flowers. Flavonoids were localized to the petals and carpels of flowers, with tissue heterogeneity in the petals. Specifically, kaempferol and/or its glycosides were abundant in the distal region of petals and quercetin and its downstream flavonoids were highly enriched in the more proximal region of petals. As a result of a mutation in the TT7 gene which blocks the conversion of dihydrokaempferol to dihydroquercetin, the downstream metabolites, quercetin, isohamnetin, and their glycosides, were not observed in the mutant flowers. Instead, the metabolites in an alternative pathway, kaempferol and/or its glycosides, were as highly abundant on the proximal region of the petals as in the distal region. In addition, the combined flavonoid amounts on the proximal region of petals in the wild-type are almost equivalent to the amounts of kaempferol and/or its glycosides in the mutant. This strongly suggests that the expression of the TT7 gene is localized on the proximal part of the petal while the other genes in the upper stream pathway are evenly expressed throughout the petal. Most importantly, this work demonstrates MSI of metabolites can be utilized for the localization of gene expression.

  6. The Effect of Therapeutic Touch Performed During Cataract Surgery on Anxiety and Patient Satisfaction

    Directory of Open Access Journals (Sweden)

    Emel Yılmaz

    2016-03-01

    Full Text Available Objective: The aim of the study was to determine the ef­fect of therapeutic touch (TT on anxiety and patient satis­faction when performed during a cataract surgery. Methods: A randomized controlled trial sample consisted of 114 individuals, 57 in the intervention group and 57 controls, who were hospitalized for cataract surgery and who conformed to the study criteria. Prior to the study approval was obtained from the ethics committee and informed consent was given by the patients. Data was collected using a personal information form, a visual analogue scale (VAS to measure anxiety, the Spielberg State/Trait Anxiety Inventory (STAI and the Newcastle Satisfaction with Nursing Care Scale (NSNCS. During the surgery, patients in the intervention group received a 15-minute session of TT. Results: In the intervention group, patients’ mean VAS anxiety score after TT was 3.56±1.85, while that of the control group in the 15th minute of the operation was 8,88±1,50. It was found that anxiety levels were reduced in the intervention group after TT compared with the con­trol group, and that vital signs were affected positively. NSNCS scores of patients in the intervention group were higher than those in the control group. Conclusion: It was observed that TT applied during sur­gery reduced anxiety, affected vital signs positively and increased patent satisfaction. The application of TT dur­ing surgery is recommended. J Clin Exp Invest 2016; 7 (1: 52-62

  7. Impact of elevated CO2 concentrations on the growth and ultrastructure of non-calcifying marine diatom (Chaetoceros gracilis F.Schütt

    Directory of Open Access Journals (Sweden)

    Hanan M. Khairy

    2014-01-01

    Full Text Available The impacts of different CO2 concentrations on the growth, physiology and ultrastructure of noncalcifying microalga Chaetoceros gracilis F.Schütt (Diatom were studied. We incubated Ch. gracilis under different CO2 concentrations, preindustrial and current ambient atmospheric concentrations (285 and 385 μatm, respectively or predicted year-2100 CO2 levels (550, 750 and 1050 μatm in continuous culture conditions. The growth of Ch. gracilis measured as cell number was decreased by increasing the pCO2 concentration from nowadays concentration (385 μatm to 1050 μatm. The lowest percentage changes of oxidizable organic matter, nitrite, nitrate, phosphate and silicate were recorded at a higher pCO2 (1050 μatm, and this is in consistence with the lowest recorded cell number indicating unsuitable conditions for the growth of Ch. gracilis. The minimum cell numbers obtained at higher levels of CO2 clearly demonstrate that, low improvement occurred when the carbon level was raised. This was confirmed by a highly negative correlation between cell number and carbon dioxide partial pressure (r = −0.742, p ⩽ 0.05. On the other hand, highest growth rate at pCO2 = 385 μatm was also confirmed by the maximum uptake of nutrient salts (NO3 = 68.96 μmol.l−1, PO4 = 29.75 μmol.l−1, Si2O3 = 36.99 μmol.l−1. Total protein, carbohydrate and lipid composition showed significant differences (p ⩽ 0.05 at different carbon dioxide concentrations during the exponential growth phase (day 8. Transmission Electron Microscopy of Ch. gracilis showed enlargement of the cell, chloroplast damage, disorganization and disintegration of thylakoid membranes; cell lysis occurs at a higher CO2 concentration (1050 μatm. It is concluded from this regression equation and from the results that the growth of Ch. gracilis is expected to decrease by increasing pCO2 and increasing ocean acidification.

  8. EFFECT OF THE ROTOR CRANK SYSTEM ON CYCLING PERFORMANCE

    Directory of Open Access Journals (Sweden)

    Simon A. Jobson

    2009-09-01

    Full Text Available The aim of this study was to evaluate the impact of a novel crank system on laboratory time-trial cycling performance. The Rotor system makes each pedal independent from the other so that the cranks are no longer fixed at 180°. Twelve male competitive but non-elite cyclists (mean ± s: 35 ± 7 yr, Wmax = 363 ± 38 W, VO2peak = 4.5 ± 0.3 L·min-1 completed 6-weeks of their normal training using either a conventional (CON or the novel Rotor (ROT pedal system. All participants then completed two 40.23-km time-trials on an air-braked ergometer, one using CON and one using ROT. Mean performance speeds were not different between trials (CON = 41.7 km·h-1 vs. ROT = 41.6 km·h-1, P > 0.05. Indeed, the pedal system used during the time-trials had no impact on any of the measured variables (power output, cadence, heart rate, VO2, RER, gross efficiency. Furthermore, the ANOVA identified no significant interaction effect between main effects (Time-trial crank system*Training crank system, P > 0.05. To the authors' knowledge, this is the first study to examine the effects of the Rotor system on endurance performance rather than endurance capacity. These results suggest that the Rotor system has no measurable impact on time-trial performance. However, further studies should examine the importance of the Rotor 'regulation point' and the suggestion that the Rotor system has acute ergogenic effects if used infrequently

  9. Relationship between maximal exercise parameters and individual ...

    African Journals Online (AJOL)

    It is widely accepted that the ventilatory threshold (VT) is an important determinant of endurance performance. This study investigated whether the physiological responses during a 20km time trial (TT) in cyclists with physical disabilities (medium to high functional ability) relate to their VT and also to determine which ...

  10. Specificity of "Live High-Train Low" altitude training on exercise performance

    DEFF Research Database (Denmark)

    Bejder, Jacob; Nordsborg, Nikolai Baastrup

    2018-01-01

    The novel hypothesis that "Live High-Train Low" (LHTL) does not improve sport-specific exercise performance (e.g., time trial) is discussed. Indeed, many studies demonstrate improved performance after LHTL but unfortunately control groups are often lacking, leaving open the possibility of training...

  11. Response Surface Methodology Modelling of an Aqueous Two-Phase System for Purification of Protease from Penicillium candidum (PCA 1/TT031) under Solid State Fermentation and Its Biochemical Characterization

    Science.gov (United States)

    Alhelli, Amaal M.; Abdul Manap, Mohd Yazid; Mohammed, Abdulkarim Sabo; Mirhosseini, Hamed; Suliman, Eilaf; Shad, Zahra; Mohammed, Nameer Khairulla; Meor Hussin, Anis Shobirin

    2016-01-01

    Penicillium candidum (PCA 1/TT031) synthesizes different types of extracellular proteases. The objective of this study is to optimize polyethylene glycol (PEG)/citrate based on an aqueous two-phase system (ATPS) and Response Surface Methodology (RSM) to purify protease from Penicillium candidum (PCA 1/TT031). The effects of different PEG molecular weights (1500–10,000 g/mol), PEG concentration (9%–20%), concentrations of NaCl (0%–10%) and the citrate buffer (8%–16%) on protease were also studied. The best protease purification could be achieved under the conditions of 9.0% (w/w) PEG 8000, 5.2% NaCl, and 15.9% sodium citrate concentration, which resulted in a one-sided protease partitioning for the bottom phase with a partition coefficient of 0.2, a 6.8-fold protease purification factor, and a yield of 93%. The response surface models displayed a significant (p ≤ 0.05) response which was fit for the variables that were studied as well as a high coefficient of determination (R2). Similarly, the predicted and observed values displayed no significant (p > 0.05) differences. In addition, our enzyme characterization study revealed that Penicillium candidum (PCA 1/TT031) produced a slight neutral protease with a molecular weight between 100 and 140 kDa. The optimal activity of the purified enzyme occurred at a pH of 6.0 and at a temperature of 50 °C. The stability between different pH and temperature ranges along with the effect of chemical metal ions and inhibitors were also studied. Our results reveal that the purified enzyme could be used in the dairy industry such as in accelerated cheese ripening. PMID:27845736

  12. Response Surface Methodology Modelling of an Aqueous Two-Phase System for Purification of Protease from Penicillium candidum (PCA 1/TT031 under Solid State Fermentation and Its Biochemical Characterization

    Directory of Open Access Journals (Sweden)

    Amaal M. Alhelli

    2016-11-01

    Full Text Available Penicillium candidum (PCA 1/TT031 synthesizes different types of extracellular proteases. The objective of this study is to optimize polyethylene glycol (PEG/citrate based on an aqueous two-phase system (ATPS and Response Surface Methodology (RSM to purify protease from Penicillium candidum (PCA 1/TT031. The effects of different PEG molecular weights (1500–10,000 g/mol, PEG concentration (9%–20%, concentrations of NaCl (0%–10% and the citrate buffer (8%–16% on protease were also studied. The best protease purification could be achieved under the conditions of 9.0% (w/w PEG 8000, 5.2% NaCl, and 15.9% sodium citrate concentration, which resulted in a one-sided protease partitioning for the bottom phase with a partition coefficient of 0.2, a 6.8-fold protease purification factor, and a yield of 93%. The response surface models displayed a significant (p ≤ 0.05 response which was fit for the variables that were studied as well as a high coefficient of determination (R2. Similarly, the predicted and observed values displayed no significant (p > 0.05 differences. In addition, our enzyme characterization study revealed that Penicillium candidum (PCA 1/TT031 produced a slight neutral protease with a molecular weight between 100 and 140 kDa. The optimal activity of the purified enzyme occurred at a pH of 6.0 and at a temperature of 50 °C. The stability between different pH and temperature ranges along with the effect of chemical metal ions and inhibitors were also studied. Our results reveal that the purified enzyme could be used in the dairy industry such as in accelerated cheese ripening.

  13. Stability of fine-grained TT-OSL and post-IR IRSL signals from a c. 1 Ma sequence of aeolian and lacustrine deposits from the Nihewan Basin (northern China)

    DEFF Research Database (Denmark)

    Liu, Jinfeng; Murray, Andrew Sean; Buylaert, Jan-Pieter

    2016-01-01

    We tested the suitability of the fine-grained quartz (4–11 μm) Optical Stimulated Luminescence (OSL) and thermally-transferred OSL (TT-OSL), and the fine-grained polymineral (4–11 μm) post-infrared IRSL (post-IR IRSL or pIRIR) signals for dating samples from aeolian-lacustrine deposits from...... accurate ones; nevertheless, these ages provide the first long series absolute chronology for study of local palaeolithic and geomorphic evolution history aside from the  magnetostratigraphical results available before this research....

  14. Psykofyysiset menetelmät kroonisen kivun hoidossa : Työelämävalmiuksia tukevan ryhmätoiminnan suunnittelu kroonisista kivuista kärsiville pitkäaikaistyöttömille

    OpenAIRE

    Jämsä, Silja

    2016-01-01

    Opinnäytetyön tarkoituksena oli kuvata psykofyysisen harjoittelun mahdollisuuksia kroonisesta kivusta kärsivien asiakkaiden kuntoutuksessa sekä suunnitella ryhmätoiminnan käytännön toteutus pitkäaikaistyöttömille pitkittyneistä kiputiloista kärsiville kuntoutujille. Työn tavoitteiksi asetettiin 1) perehtyminen teoreettiselta näkökannalta psykofyysiseen fysioterapiaan ja krooniseen kipuun sekä tutustuminen psykofyysiseen viitekehykseen kuuluviin lähestymistapoihin, menetelmiin ja harjoitteisii...

  15. Tagging calibration of the jets from beauty quarks and the search for Higgs boson in the tt-bar H → lνb, jjb, bb-bar channel in the ATLAS experiment at LHC

    International Nuclear Information System (INIS)

    Correard, Sebastien

    2006-02-01

    B-tagging calibration and search for the Higgs boson in the tt-bar H → lνb, jjb, bb-bar channel with ATLAS at LHC The ATLAS experiment, based at CERN, will use the LHC proton collisions to deepen the Standard Model measurements, and look for possible signs of new physics. One of its main tasks will be the search for the Higgs boson. This thesis first describes the latest b-tagging algorithms, shows the importance of its calibration, and proposes a b-tagging calibration method based on the first data recorded by ATLAS. Then, considering that the Higgs boson may be light (m H 2 ), the ttH channel is studied, with H decaying in a b quark pair. Full simulation and the latest realistic b-tagging methods have been combined for the first time. For an integrated luminosity of 30 fb -1 (3 years of data taking), the S/√B ratio, determining the sensitivity of this analysis, is raised to 4.9. This should allow a non-ambiguous observation of the Higgs boson in this channel. (author)

  16. Tagging calibration of the jets from beauty quarks and the search for Higgs boson in the tt-bar H {yields} l{nu}b, jjb, bb-bar channel in the ATLAS experiment at LHC; Calibration de l'etiquetage de jets issus de quarks beaux et recherche du boson de Higgs dans le canal tt-barH {yields} l{nu}b, jjb, bb-bar dans l'experience ATLAS aupres du LHC

    Energy Technology Data Exchange (ETDEWEB)

    Correard, Sebastien [Faculte des Sciences de Luminy, Universite de la Mediterranee, Aix-Marseille II, 163 avenue de Luminy, 13288 Marseille cedex 09 (France)

    2006-02-15

    B-tagging calibration and search for the Higgs boson in the tt-bar H {yields} l{nu}b, jjb, bb-bar channel with ATLAS at LHC The ATLAS experiment, based at CERN, will use the LHC proton collisions to deepen the Standard Model measurements, and look for possible signs of new physics. One of its main tasks will be the search for the Higgs boson. This thesis first describes the latest b-tagging algorithms, shows the importance of its calibration, and proposes a b-tagging calibration method based on the first data recorded by ATLAS. Then, considering that the Higgs boson may be light (m{sub H} < 135 GeV/c{sup 2}), the ttH channel is studied, with H decaying in a b quark pair. Full simulation and the latest realistic b-tagging methods have been combined for the first time. For an integrated luminosity of 30 fb{sup -1} (3 years of data taking), the S/{radical}B ratio, determining the sensitivity of this analysis, is raised to 4.9. This should allow a non-ambiguous observation of the Higgs boson in this channel. (author)

  17. Endurance, aerobic high-intensity, and repeated sprint cycling performance is unaffected by normobaric "Live High-Train Low"

    DEFF Research Database (Denmark)

    Bejder, Jacob; Andersen, Andreas Breenfeldt; Buchardt, Rie

    2017-01-01

    The aim was to investigate whether 6 weeks of normobaric "Live High-Train Low" (LHTL) using altitude tents affect highly trained athletes incremental peak power, 26-km time-trial cycling performance, 3-min all-out performance, and 30-s repeated sprint ability. In a double-blinded, placebo......-controlled cross-over design, seven highly trained triathletes were exposed to 6 weeks of normobaric hypoxia (LHTL) and normoxia (placebo) for 8 h/day. LHTL exposure consisted of 2 weeks at 2500 m, 2 weeks at 3000 m, and 2 weeks at 3500 m. Power output during an incremental test, ~26-km time trial, 3-min all...... conducted in a double-blinded, placebo-controlled cross-over design do not affect power output during an incremental test, a ~26-km time-trial test, or 3-min all-out exercise in highly trained triathletes. Furthermore, 30 s of repeated sprint ability was unaltered....

  18. Relationship Between Jumping Ability, Agility and Sprint Performance of Elite Young Basketball Players: A Field-Test Approach

    Directory of Open Access Journals (Sweden)

    Abbas Asadi

    2016-05-01

    Full Text Available DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n2p177   The purpose of this study was to determine the relationships between sprint, agility and jump performance of elite young basketball players. Sixteen elite national level young male basketball players participated in this study. The jumping ability of each player was determined using countermovement jump (CMJ, and broad long jump (BLJ. The agility T test (TT and Illinois agility test (IAT were assessed to determine the agility, and 20-m sprint time was also measured to determine sprint performance. The results of Pearson Product Moment Correlation analysis indicated moderate correlation between training age and IAT (r = -0.57; p = 0.021. Strong correlations were found between CMJ and BLJ (r = 0.71; p = 0.002, and between TT and IAT (r = 0.70; p = 0.002. Similarly, 20-m sprint time was strong correlated with CMJ (r = -0.61; p = 0.011, BLJ (r = -0.76; p = 0.001, TT (r = 0.77; p = 0.001, and IAT (r = 0.68; p = 0.003. In addition, CMJ was strongly correlated with TT (r = -0.60; p = 0.013, and IAT (r = -0.64; p = 0.007, and also strong correlation between BLJ with TT (r = -0.85; p = 0.001 and IAT (r = -0.76; p = 0.001. The findings of the present study indicated significant correlation between sprint and agility, jumping ability and sprint performance and between jumping ability and agility performance in basketball players. Therefore, the results suggest that sprint, agility and jumping ability share common physiological and biomechanical determinants.

  19. Exercise performance, red blood cell deformability, and lipid peroxidation: effects of fish oil and vitamin E

    NARCIS (Netherlands)

    Oostenbrug, G. S.; Mensink, R. P.; Hardeman, M. R.; de Vries, T.; Brouns, F.; Hornstra, G.

    1997-01-01

    Previous studies have indicated that fish oil supplementation increases red blood cell (RBC) deformability, which may improve exercise performance. Exercise alone, or in combination with an increase in fatty acid unsaturation, however, may enhance lipid peroxidation. Effects of a bicycle time trial

  20. Effects of caffeine chewing gum on race performance and physiology in male and female cyclists.

    Science.gov (United States)

    Paton, Carl; Costa, Vitor; Guglielmo, Luiz

    2015-01-01

    This investigation reports the effects of chewing caffeinated gum on race performance with trained cyclists. Twenty competitive cyclists completed two 30-km time trials that included a maximal effort 0.2-km sprint each 10-km. Caffeine (~3-4 mg · kg(-1)) or placebo was administered double-blind via chewing gum at the 10-km point following completion of the first sprint. Measures of power output, oxygen uptake, heart rate, lactate and perceived exertion were taken at set intervals during the time trial. Results indicated no substantial differences in any measured variables between caffeine and placebo conditions during the first 20-km of the time trial. Caffeine gum did however lead to substantial enhancements (mean ± 90% confidence limits (CLs)) in mean power during the final 10-km (3.8% ± 2.3%), and sprint power at 30-km (4.0% ± 3.6%). The increases in performance over the final 10-km were associated with small increases in heart rate and blood lactate (effect size of 0.24 and 0.28, respectively). There were large inter-individual variations in the response to caffeine, and apparent gender related differences in sprint performance. Chewing caffeine gum improves mean and sprint performance power in the final 10-km of a 30-km time trial in male and female cyclists most likely through an increase in nervous system activation.

  1. Tribulus terrestris extracts alleviate muscle damage and promote anaerobic performance of trained male boxers and its mechanisms: Roles of androgen, IGF-1, and IGF binding protein-3

    Directory of Open Access Journals (Sweden)

    Yiming Ma

    2017-12-01

    Conclusion: Taking 1250 mg capsules containing TT extracts did not change muscle mass and plasma levels of testosterone, DHT, and IGF-1 but significantly alleviated muscle damage and promoted anaerobic performance of trained male boxers, which may be related to the decrease of plasma IGFBP-3 rather than androgen in plasma.

  2. High Performance Ambipolar Diketopyrrolopyrrole-Thieno[3,2-b]thiophene Copolymer Field-Effect Transistors with Balanced Hole and Electron Mobilities

    DEFF Research Database (Denmark)

    Chen, Zhuoying; Lee, Mi Jung; Ashraf, Raja Shahid

    2012-01-01

    Ambipolar OFETs with balanced hole and electron field-effect mobilities both exceeding 1 cm2 V−1 s−1 are achieved based on a single-solution-processed conjugated polymer, DPPT-TT, upon careful optimization of the device architecture, charge injection, and polymer processing. Such high-performance...

  3. Background estimation in the associated Higgs boson top-quark production channel ttH → 2l + 1 τ{sub had} at √(s) = 13 TeV with ATLAS

    Energy Technology Data Exchange (ETDEWEB)

    Ali, Babar; Sopczak, Andre [IEAP CTU in Prague (Czech Republic); Gentile, Simonetta; Kuna, Marine; Monzani, Simone; Seifert, Frank [La Sapienza Universita, Roma (Italy); INFN, Roma (Italy)

    2016-07-01

    The measurement of the associated production of a Higgs boson with a pair of top quarks is a direct determination of the top-Yukawa coupling at tree-level, which can be compared with the indirect determination in the loop-production via gluon-gluon fusion. The decay channel of the system with several leptons (multi-lepton channel) and jets gives high sensitivity. The focus of the analysis is the sub-channel with two same-sign light leptons (electrons or muons) and a hadronically decaying tau lepton: ttH → 2l + 1 τ{sub had}. In particular the background estimate from top-antitop reactions is discussed. The analysis uses the data set recorded by ATLAS in 2015 from the first LHC Run-II 13 TeV proton-proton collisions.

  4. Measurement of the tt production cross section in pp collisions at square root s = 1.96 TeV using missing E(T) + jets events with secondary vertex b tagging.

    Science.gov (United States)

    Abulencia, A; Acosta, D; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Ambrose, D; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J-F; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Bachacou, H; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Bedeschi, F; Behari, S; Belforte, S; Bellettini, G; Bellinger, J; Belloni, A; Ben-Haim, E; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Bishai, M; Blair, R E; Blocker, C; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Bourov, S; Boveia, A; Brau, B; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carron, S; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chapman, J; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Chu, P H; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Ciljak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Connolly, A; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Cruz, A; Cuevas, J; Culbertson, R; Cyr, D; DaRonco, S; D'Auria, S; D'Onofrio, M; Dagenhart, D; de Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; Dell'orso, M; Demers, S; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Dionisi, C; Dittmann, J R; DiTuro, P; Dörr, C; Dominguez, A; Donati, S; Donega, M; Dong, P; Donini, J; Dorigo, T; Dube, S; Ebina, K; Efron, J; Ehlers, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Field, R; Flanagan, G; Flores-Castillo, L R; Foland, A; Forrester, S; Foster, G W; Franklin, M; Freeman, J C; Fujii, Y; Furic, I; Gajjar, A; Gallinaro, M; Galyardt, J; Garcia, J E; Garcia Sciveres, M; Garfinkel, A F; Gay, C; Gerberich, H; Gerchtein, E; Gerdes, D; Giagu, S; Giannetti, P; Gibson, A; Gibson, K; Ginsburg, C; Giolo, K; Giordani, M; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Gotra, Y; Goulianos, K; Gresele, A; Griffiths, M; Grinstein, S; Grosso-Pilcher, C; Grundler, U; da Costa, J Guimaraes; Haber, C; Hahn, S R; Hahn, K; Halkiadakis, E; Hamilton, A; Han, B-Y; Handler, R; Happacher, F; Hara, K; Hare, M; Harper, S; Harr, R F; Harris, R M; Hatakeyama, K; Hauser, J; Hays, C; Hayward, H; Heijboer, A; Heinemann, B; Heinrich, J; Hennecke, M; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Huston, J; Ikado, K; Incandela, J; Introzzi, G; Iori, M; Ishizawa, Y; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jensen, H; Jeon, E J; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Kang, J; Karagoz-Unel, M; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, M S; Kim, S B; Kim, S H; Kim, Y K; Kirby, M; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kobayashi, H; Kondo, K; Kong, D J; Konigsberg, J; Kordas, K; Korytov, A; Kotwal, A V; Kovalev, A; Kraus, J; Kravchenko, I; Kreps, M; Kreymer, A; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; Lecci, C; LeCompte, T; Lee, J; Lee, J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Li, K; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Liss, T M; Lister, A; Litvintsev, D O; Liu, T; Liu, Y; Lockyer, N S; Loginov, A; Loreti, M; Loverre, P; Lu, R-S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Maksimovic, P; Manca, G; Margaroli, F; Marginean, R; Marino, C; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McGivern, D; McIntyre, P; McNamara, P; McNulty, R; Mehta, A; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; von der Mey, M; Miao, T; Miladinovic, N; Miles, J; Miller, R; Miller, J S; Mills, C; Milnik, M; Miquel, R; Miscetti, S; Mitselmakher, G; Miyamoto, A; Moggi, N; Mohr, B; Moore, R; Morello, M; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Mulhearn, M; Muller, Th; Mumford, R; Murat, P; Nachtman, J; Nahn, S; Nakano, I; Napier, A; Naumov, D; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nigmanov, T; Nodulman, L; Norniella, O; Ogawa, T; Oh, S H; Oh, Y D; Okusawa, T; Oldeman, R; Orava, R; Osterberg, K; Pagliarone, C; Palencia, E; Paoletti, R; Papadimitriou, V; Papikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Piedra, J; Pitts, K; Plager, C; Pondrom, L; Pope, G; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Rakitin, A; Rappoccio, S; Ratnikov, F; Reisert, B; Rekovic, V; van Remortel, N; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Rinnert, K; Ristori, L; Robertson, W J; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Rott, C; Ruiz, A; Russ, J; Rusu, V; Ryan, D; Saarikko, H; Sabik, S; Safonov, A; Sakumoto, W K; Salamanna, G; Salto, O; Saltzberg, D; Sanchez, C; Santi, L; Sarkar, S; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Semeria, F; Sexton-Kennedy, L; Sfiligoi, I; Shapiro, M D; Shears, T; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sill, A; Sinervo, P; Sisakyan, A; Sjolin, J; Skiba, A; Slaughter, A J; Sliwa, K; Smirnov, D; Smith, J R; Snider, F D; Snihur, R; Soderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; St Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Taffard, A; Tafirout, R; Takashima, R; Takeuchi, Y; Takikawa, K; Tanaka, M; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Tether, S; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tollefson, K; Tomura, T; Tonelli, D; Tönnesmann, M; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuchiya, R; Tsuno, S; Turini, N; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vacavant, L; Vaiciulis, A; Vallecorsa, S; Varganov, A; Vataga, E; Velev, G; Veramendi, G; Veszpremi, V; Vickey, T; Vidal, R; Vila, I; Vilar, R; Vollrath, I; Volobouev, I; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner, W; Wallny, R; Walter, T; Wan, Z; Wang, M J; Wang, S M; Warburton, A; Ward, B; Waschke, S; Waters, D; Watts, T; Weber, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Worm, S; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, Y; Yang, C; Yang, U K; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhang, X; Zhou, J; Zucchelli, S

    2006-05-26

    We present a measurement of the tt production cross section in pp collisions at square root s = 1.96 TeV which uses events with an inclusive signature of significant missing transverse energy and jets. This is the first measurement which makes no explicit lepton identification requirements, so that sensitivity to W --> tau nu decays is maintained. Heavy flavor jets from top quark decay are identified with a secondary vertex tagging algorithm. From 311 pb(-1) of data collected by the Collider Detector at Fermilab, we measure a production cross section of 5.8 +/- 1.2(stat)(-0.7)(+0.9)(syst) pb for a top quark mass of 178 GeV/c2, in agreement with previous determinations and standard model predictions.

  5. R25. ROGATIONS POUR LA PLUIE : Ɣunja, Tlaɣ°nja, Ttǝl-ɣǝnja, Tlɣnja, Bǝlɣ°nja : Note ‎ethnolinguistique complémentaire

    OpenAIRE

    CHAKER , Salem; Ameur , Meftaha

    2017-01-01

    International audience; R25. ROGATIONS POUR LA PLUIE : Ɣunja, Tlaɣ°nja, Ttǝl-ɣǝnja, Tlɣnja, Bǝlɣ°nja : Note ethnolinguistique complémentaire. Les dénominations du rite d'obtention de la pluie présentent de nombreuses variantes. Tlaɣ°nja, forme relevée par Marie-Luce Gélard dans le sud-est marocain, est peut-être à analyser en tla-ɣ°nja = « elle a/possède la cuillère à pot » (?). Mais les variantes sont très diverses : on relève notamment (Ayt Sadden, A. Roux, Textes berbères du Maroc central,...

  6. POLCA-T simulation of OECD/NRC BWR turbine trip benchmark exercise 3 best estimate scenario TT2 test and four extreme scenarios

    International Nuclear Information System (INIS)

    Panayotov, D.

    2004-01-01

    Westinghouse transient code POLCA-T brings together the system thermal-hydraulics plant models and the 3D neutron kinetics core model. Code validation plan includes the calculations of Peach Bottom end of cycle 2 turbine trip transients and low-flow stability tests. The paper describes the objectives, method, and results of analyses performed in the final phase of OECD/NRC Peach Bottom 2 Boiling Water Reactor Turbine Trip Benchmark. Brief overview of the code features, the method of simulation, the developed 3D core model and system input deck for Peach Bottom 2 are given. The paper presents the results of benchmark exercise 3 best estimate scenario: coupled 3D core neutron kinetics with system thermal-hydraulics analyses. Performed sensitivity studies cover the SCRAM initiation, carry-under, and decay power. Obtained results including total power, steam dome, core exit, lower and upper plenum, main steam line and turbine inlet pressures showed good agreement with measured plant data Thus the POLCA-T code capabilities for correct simulation of turbine trip transients were proved The performed calculations and obtained results for extreme cases demonstrate the POLCA-T code wide range capabilities to simulate transients when scram, steam bypass, and safety and relief valves are not activated. The code is able to handle such transients even when the reactor power and pressure reach values higher than 600 % of rated power, and 10.8 MPa. (authors)

  7. Acute Impact of Inhaled Short Acting B-Agonists on 5 Km Running Performance

    Directory of Open Access Journals (Sweden)

    John Dickinson

    2014-06-01

    Full Text Available Whilst there appears to be no ergogenic effect from inhaled salbutamol no study has investigated the impact of the acute inhalation of 1600 µg, the World Anti-Doping Agency (WADA daily upper limit, on endurance running performance. To investigate the ergogenic effect of an acute inhalation of short acting β2-agonists at doses up to 1600 µg on 5 km time trial performance and resultant urine concentration. Seven male non-asthmatic runners (mean ± SD; age 22.4 ± 4.3 years; height 1.80 ± 0.07 m; body mass 76.6 ± 8.6 kg provided written informed consent. Participants completed six 5 km time-trials on separate days (three at 18 °C and three at 30 °C. Fifteen minutes prior to the initiation of each 5 km time-trial participants inhaled: placebo (PLA, 800 µg salbutamol (SAL800 or 1600 µg salbutamol (SAL1600. During each 5 km time-trial HR, VO2, VCO2, VE, RPE and blood lactate were measured. Urine samples (90 ml were collected between 30-180 minutes post 5 km time-trial and analysed for salbutamol concentration. There was no significant difference in total 5 km time between treatments (PLA 1714.7 ± 186.2 s; SAL800 1683.3 ± 179.7 s; SAL1600 1683.6 ± 190.7 s. Post 5 km time-trial salbutamol urine concentration between SAL800 (122.96 ± 69.22 ug·ml-1 and SAL1600 (574.06 ± 448.17 ug·ml-1 were not significantly different. There was no improvement in 5 km time-trial performance following the inhalation of up to 1600 µg of salbutamol in non-asthmatic athletes. This would suggest that the current WADA guidelines, which allow athletes to inhale up to 1600 µg per day, is sufficient to avoid pharmaceutical induced performance enhancement.

  8. Measurement of the W-boson mass in top-quark decays from tt-bar production in lepton and jets events in proton-proton collisions

    CERN Document Server

    Alsaidi, Warda

    2017-01-01

    A measurement is performed of the mass of the W-boson produced in top quarks events. CMS data was used and simulation samples from previous top studies in the CERN CMS group to develop this new analysis method. The measurement is based on $13 TeV$ proton-proton collision data corresponding to and integrated luminosity of $35.9 fb^{-1}$, the measured mass of the W-boson was found to be equal $m_w=80.317\\pm0.072 \\text{(stat)}\\pm1.315{(syst)}\\pm1.317{(Total)} GeV$ to and the measurement of the mass difference between the W+and W- bosons yields $m_{W+}- m_{W-}=0.008\\pm0.149{(stat)}\\pm0.488{(syst)}\\pm0.509 {(Total)} GeV$ . The results where compared with PDG, Tevatron’s, LEP and ATLAS (2017).

  9. Pre-task music improves swimming performance.

    Science.gov (United States)

    Smirmaul, B P; Dos Santos, R V; Da Silva Neto, L V

    2015-12-01

    The purpose of this study was to investigate the effects of pre-task music on swimming performance and other psychological variables. A randomized counterbalanced within-subjects (experimental and control condition) design was employed. Eighteen regional level male swimmers performed two 200-m freestyle swimming time trials. Participants were exposed to either 5 minutes of self-selected music (pre-task music condition) or 5 minutes of silence (control condition) and, after 1 minute, performed the swimming task. Swimming time was significantly shorter (-1.44%) in the pre-task music condition. Listening to pre-task music increased motivation to perform the swimming task, while arousal remained unchanged. While fatigue increased after the swimming task in both conditions, vigor, ratings of perceived exertion and affective valence were unaltered. It is concluded, for the first time, that pre-task music improves swimming performance.

  10. Aggregation Strength Tuning in Difluorobenzoxadiazole-Based Polymeric Semiconductors for High-Performance Thick-Film Polymer Solar Cells.

    Science.gov (United States)

    Chen, Peng; Shi, Shengbin; Wang, Hang; Qiu, Fanglong; Wang, Yuxi; Tang, Yumin; Feng, Jian-Rui; Guo, Han; Cheng, Xing; Guo, Xugang

    2018-06-27

    High-performance polymer solar cells (PSCs) with thick active layers are essential for large-scale production. Polymer semiconductors exhibiting a temperature-dependent aggregation property offer great advantages toward this purpose. In this study, three difluorobenzoxadiazole (ffBX)-based donor polymers, PffBX-T, PffBX-TT, and PffBX-DTT, were synthesized, which contain thiophene (T), thieno[3,2- b]thiophene (TT), and dithieno[3,2- b:2',3'- d]thiophene (DTT) as the π-spacers, respectively. Temperature-dependent absorption spectra reveal that the aggregation strength increases in the order of PffBX-T, PffBX-TT, and PffBX-DTT as the π-spacer becomes larger. PffBX-TT with the intermediate aggregation strength enables well-controlled disorder-order transition in the casting process of blend film, thus leading to the best film morphology and the highest performance in PSCs. Thick-film PSCs with an average power conversion efficiency (PCE) of 8.91% and the maximum value of 9.10% are achieved using PffBX-TT:PC 71 BM active layer with a thickness of 250 nm. The neat film of PffBX-TT also shows a high hole mobility of 1.09 cm 2 V -1 s -1 in organic thin-film transistors. When PffBX-DTT and PffBX-T are incorporated into PSCs utilizing PC 71 BM acceptor, the average PCE decreases to 6.54 and 1.33%, respectively. The performance drop mainly comes from reduced short-circuit current, as a result of nonoptimal blend film morphology caused by a less well-controlled film formation process. A similar trend was also observed in nonfullerene type thick-film PSCs using IT-4F as the electron acceptor. These results show the significance of polymer aggregation strength tuning toward optimal bulk heterojunction film morphology using ffBX-based polymer model system. The study demonstrates that adjusting π-spacer is an effective method, in combination with other important approaches such as alkyl chain optimization, to generate high-performance thick-film PSCs which are critical for

  11. Expected Particle Fluences and Performance of the LHCb Trigger Tracker

    CERN Document Server

    Siegler, M; Needham, M; Steinkamp, O

    2004-01-01

    Monte Carlo simulations of the expected 1 MeV-neutron equivalent fluence in the Trigger Tracker (TT) station of the LHCb detector have been used to investigate the effect of radiation damage on the performance of the detector. The build-up of leakage currents and the corresponding increase in electronic noise has been investigated, as well as the effect of bulk damage on the full-depletion voltage of the sensors and the risk of thermal runaway due to the power generated due to the leakage currents.

  12. Prime Time Light Exposures Do Not Seem to Improve Maximal Physical Performance in Male Elite Athletes, but Enhance End-Spurt Performance

    Directory of Open Access Journals (Sweden)

    Arno Schmidt-Trucksäss

    2017-05-01

    Full Text Available Many sports competitions take place during television prime time, a time of the day when many athletes have already exceeded their time of peak performance. We assessed the effect of different light exposure modalities on physical performance and melatonin levels in athletes during prime time. Seventy-two young, male elite athletes with a median (interquartile range age of 23 (21; 29 years and maximum oxygen uptake (VO2max of 63 (58; 66 ml/kg/min were randomly assigned to three different light exposure groups: bright light (BRIGHT, blue monochromatic light (BLUE, and control light (CONTROL. Each light exposure lasted 60 min and was scheduled to start 17 h after each individual's midpoint of sleep (median time: 9:17 pm. Immediately after light exposure, a 12-min time trial was performed on a bicycle ergometer. The test supervisor and participants were blinded to the light condition each participant was exposed to. The median received light intensities and peak wavelengths (photopic lx/nm measured at eye level were 1319/545 in BRIGHT, 203/469 in BLUE, and 115/545 in CONTROL. In a multivariate analysis adjusted for individual VO2max, total work performed in 12 min did not significantly differ between the three groups. The amount of exposure to non-image forming light was positively associated with the performance gain during the time trial, defined as the ratio of the work performed in the first and last minute of the time trial, and with stronger melatonin suppression. Specifically, a tenfold increase in the exposure to melanopic light was associated with a performance gain of 8.0% (95% confidence interval: 2.6, 13.3; P = 0.004 and a melatonin decrease of −0.9 pg/ml (95% confidence interval: −1.5, −0.3; P = 0.006. Exposure to bright or blue light did not significantly improve maximum cycling performance in a 12-min all-out time trial. However, it is noteworthy that the estimated difference of 4.1 kJ between BRIGHT and CONTROL might represent

  13. Prime Time Light Exposures Do Not Seem to Improve Maximal Physical Performance in Male Elite Athletes, but Enhance End-Spurt Performance

    Science.gov (United States)

    Knaier, Raphael; Schäfer, Juliane; Rossmeissl, Anja; Klenk, Christopher; Hanssen, Henner; Höchsmann, Christoph; Cajochen, Christian; Schmidt-Trucksäss, Arno

    2017-01-01

    Many sports competitions take place during television prime time, a time of the day when many athletes have already exceeded their time of peak performance. We assessed the effect of different light exposure modalities on physical performance and melatonin levels in athletes during prime time. Seventy-two young, male elite athletes with a median (interquartile range) age of 23 (21; 29) years and maximum oxygen uptake (VO2max) of 63 (58; 66) ml/kg/min were randomly assigned to three different light exposure groups: bright light (BRIGHT), blue monochromatic light (BLUE), and control light (CONTROL). Each light exposure lasted 60 min and was scheduled to start 17 h after each individual's midpoint of sleep (median time: 9:17 pm). Immediately after light exposure, a 12-min time trial was performed on a bicycle ergometer. The test supervisor and participants were blinded to the light condition each participant was exposed to. The median received light intensities and peak wavelengths (photopic lx/nm) measured at eye level were 1319/545 in BRIGHT, 203/469 in BLUE, and 115/545 in CONTROL. In a multivariate analysis adjusted for individual VO2max, total work performed in 12 min did not significantly differ between the three groups. The amount of exposure to non-image forming light was positively associated with the performance gain during the time trial, defined as the ratio of the work performed in the first and last minute of the time trial, and with stronger melatonin suppression. Specifically, a tenfold increase in the exposure to melanopic light was associated with a performance gain of 8.0% (95% confidence interval: 2.6, 13.3; P = 0.004) and a melatonin decrease of −0.9 pg/ml (95% confidence interval: −1.5, −0.3; P = 0.006). Exposure to bright or blue light did not significantly improve maximum cycling performance in a 12-min all-out time trial. However, it is noteworthy that the estimated difference of 4.1 kJ between BRIGHT and CONTROL might represent an

  14. Die transkripsielees van T.T. Cloete

    Directory of Open Access Journals (Sweden)

    T. Gouws

    1989-05-01

    Full Text Available In a transcriptual approach to the literary discourse, the text as artefact is regarded as a creation of the scriptor. The artificiality of the poetics implies conscious or unconscious structuring - Cloete terms it dreamful thinking (“die dromende denke” - by inevitably exploiting language conventions and the poetic devices, the sole purpose being that the organised composition can be the only (as well as measurable indication of authorial intention. Likewise, in as far as language presents the relevant possibilities, authorial intention is imprinted upon the textual composition or is transposed lingually. Moreover, a transcriptual reading of Cloete texts has shown clearly that the text as language presentation exhibits a wilfulness, a creative language potency or energy which has to be activated by the reader. This dynamic, significatory potency is not constricted by the authorial intention; rather, it offers a framework within which language may claim to determinate actualisation. Realisation by the reader is therefore nothing more than a transcript of the possibilities and presentation of language. Added to this is the following qualification that this transcriptual process brings about an aesthetically realised object which is the imprint of the reader’s understanding. By reading Cloete’s poetry through transcriptually tinted glasses, the richness of this reading strategy becomes clear.

  15. Boiling water reactor turbine trip (TT) benchmark

    International Nuclear Information System (INIS)

    2005-01-01

    In the field of coupled neutronics/thermal-hydraulics computation there is a need to enhance scientific knowledge in order to develop advanced modelling techniques for new nuclear technologies and concepts as well as for current applications. Recently developed 'best-estimate' computer code systems for modelling 3-D coupled neutronics/thermal-hydraulics transients in nuclear cores and for coupling core phenomena and system dynamics (PWR, BWR, VVER) need to be compared against each other and validated against results from experiments. International benchmark studies have been set up for this purpose. The present report is the second in a series of four and summarises the results of the first benchmark exercise, which identifies the key parameters and important issues concerning the thermalhydraulic system modelling of the transient, with specified core average axial power distribution and fission power time transient history. The transient addressed is a turbine trip in a boiling water reactor, involving pressurization events in which the coupling between core phenomena and system dynamics plays an important role. In addition, the data made available from experiments carried out at the Peach Bottom 2 reactor (a GE-designed BWR/4) make the present benchmark particularly valuable. (author)

  16. tt ja Pikkov Euroopas edukad

    Index Scriptorium Estoniae

    2003-01-01

    Barcelona 6. rahvusvahelisel lühifilmide festivalil sai Ülo Pikkovi joonisfilm "Ahviaasta" tähtsuselt teise auhinna ja Šveitsis Badeni 4. rahvusvahelisel animafilmide festivalil sai Mati Küti "Nööbi odüsseia" preemia parima kunstilise lahenduse eest

  17. ME technique plus experience ttH

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    The Matrix Element Method (MEM) is a HEP-specific technique to directly calculate the likelihood for a collision event based on the “matrix elements” of quantum field theory and a simplified detector description. The goal of this talk is to be a description of the matrix element method, current implementations, and comparisons with other multivariate approaches.

  18. Potential and limits of OSL, TT-OSL, IRSL and pIRIR290 dating methods applied on a Middle Pleistocene sediment record of Lake El'gygytgyn, Russia

    Directory of Open Access Journals (Sweden)

    A. Zander

    2013-03-01

    Full Text Available This study tests the paleomagnetic and proxy-data based Mid- to Upper Pleistocene sediment deposition history of Lake El'gygytgyn by applying different approaches of luminescence dating techniques on sediment cores taken from the centre of the 175 m deep lake. For dating polymineral and quartz fine grains (4–11 μm grain size range were extracted from nine different levels from the upper 28 m of sediment cores 5011-1A and 5011-1B. According to the independent age model, the lowest sample from 27.8–27.9 m below lake bottom level correlates to the Brunhes-Matuyama (B/M reversal. Polymineral sub-samples were analysed by infra-red stimulated luminescence (IRSL and post-IR IRSL measured at 290 °C (pIRIR290 using single aliquot regenerative dose (SAR sequences. SAR protocols were further applied to measure the blue light optically stimulated luminescence (OSL and thermally-transferred OSL (TT-OSL of fine-grained quartz supplemented by a multiple aliquot approach. Neither low temperature IRSL measurements at 50 °C nor any OSL dating approach on quartz yielded reliable results. Deconvolution of their dose response curves revealed a pseudo-increase of the dose response curves and explains the observed underestimation. The pIRIR protocol applied to polymineral fine grains was the only luminescence technique able to provide dating results of acceptable accuracy up to ca. 700 ka when correlated to the existing proxy-data and paleomagnetic based age record. We present the potential and limits of the different dating techniques and a correlation of pIRIR290 results with the proxy-data based age model.

  19. High-dose inhaled terbutaline increases muscle strength and enhances maximal sprint performance in trained men

    DEFF Research Database (Denmark)

    Hostrup, Morten; Kalsen, Anders; Bangsbo, Jens

    2014-01-01

    ) participated in a double-blinded randomized crossover study. After administration of inhaled terbutaline (30 × 0.5 mg) or placebo, subjects' maximal voluntary isometric contraction (MVC) of m.quadriceps was measured. After MVC, subjects performed a 30-s Wingate test. Sixty minutes following the Wingate test......, subjects exercised for 10 min at 80 % of [Formula: see text] and completed a 100-kcal time trial. Aerobic contribution was determined during the Wingate test by indirect calorimetry. Furthermore, plasma terbutaline, lactate, glucose, and K(+) were measured. RESULTS: Inhalation of 15 mg terbutaline resulted...... = 0.019) and 3.3 ± 1.0 % (P = 0.009) higher for terbutaline than placebo. Net accumulation of plasma lactate was higher (P = 0.003) for terbutaline than placebo during the Wingate test, whereas [Formula: see text] above baseline was unchanged by terbutaline (P = 0.882). Time-trial performance...

  20. Performing Performance Design Anglonationally

    DEFF Research Database (Denmark)

    2016-01-01

    Video recording of pecha kucha style bricolage aural enactment of an international version of performance design......Video recording of pecha kucha style bricolage aural enactment of an international version of performance design...

  1. Substrate Utilization and Cycling Performance Following Palatinose™ Ingestion: A Randomized, Double-Blind, Controlled Trial

    Directory of Open Access Journals (Sweden)

    Daniel König

    2016-06-01

    Full Text Available (1 Objective: To compare the effects of isomaltulose (Palatinose™, PSE vs. maltodextrin (MDX ingestion on substrate utilization during endurance exercise and subsequent time trial performance; (2 Methods: 20 male athletes performed two experimental trials with ingestion of either 75 g PSE or MDX 45 min before the start of exercise. The exercise protocol consisted of 90 min cycling (60% VO2max followed by a time trial; (3 Results: Time trial finishing time (−2.7%, 90% CI: ±3.0%, 89% likely beneficial; p = 0.147 and power output during the final 5 min (+4.6%, 90% CI: ±4.0%, 93% likely beneficial; p = 0.053 were improved with PSE compared with MDX. The blood glucose profile differed between trials (p = 0.013 with PSE resulting in lower glycemia during rest (95%–99% likelihood and higher blood glucose concentrations during exercise (63%–86% likelihood. In comparison to MDX, fat oxidation was higher (88%–99% likelihood; p = 0.005 and carbohydrate oxidation was lower following PSE intake (85%–96% likelihood; p = 0.002. (4 Conclusion: PSE maintained a more stable blood glucose profile and higher fat oxidation during exercise which resulted in improved cycling performance compared with MDX. These results could be explained by the slower availability and the low-glycemic properties of Palatinose™ allowing a greater reliance on fat oxidation and sparing of glycogen during the initial endurance exercise.

  2. Tetanus-diphtheria-pertussis vaccine may suppress the immune response to subsequent immunization with pneumococcal CRM197-conjugate vaccine (coadministered with quadrivalent meningococcal TT-conjugate vaccine): a randomized, controlled trial⋆.

    Science.gov (United States)

    Tashani, Mohamed; Heron, Leon; Wong, Melanie; Rashid, Harunor; Booy, Robert

    2017-07-01

    : Due to their antigenic similarities, there is a potential for immunological interaction between tetanus/diphtheria-containing vaccines and carrier proteins presented on conjugate vaccines. The interaction could, unpredictably, result in either enhancement or suppression of the immune response to conjugate vaccines if they are injected soon after or concurrently with diphtheria or tetanus toxoid. We examined this interaction among adult Australian travellers before attending the Hajj pilgrimage of 2015. We randomly assigned each participant to one of three vaccination schedules. Group A received tetanus, diphtheria and acellular pertussis vaccine (Tdap) 3-4 weeks before receiving CRM197-conjugated 13-valent pneumococcal vaccine (PCV13) coadministered with TT-conjugated quadrivalent meningococcal vaccine (MCV4). Group B received all three vaccines concurrently. Group C received PCV13 and MCV4 3-4 weeks before Tdap. Blood samples collected at baseline, at each vaccination visit and 3-4 weeks after vaccination were tested for the pneumococcal opsonophagocytic assay (OPA). A total of 166 participants aged 18-64 (median 42) years were recruited, 159 completed the study. Compared with the other groups, Group A had significantly ( P  vaccination in seven serotypes of PCV13 (1, 3, 4, 5, 14, 18C and 9V). Additionally, Group A had lower frequency of serorises (≥ 4-fold rise in OPA titres) in serotype5 (79%, p = 0.01) and 18C (73.5%, p = 0.06); whereas Groups B and C had significantly lower frequencies of serorises in Serotype 4 (82%) and 6A (73.5%), respectively. No statistically significant difference was detected across the three groups in frequencies achieving OPA titre ≥ 1:8 post-vaccination. Tdap vaccination 3-4 weeks before administration of PCV13 and MCV4 significantly reduced the GMTs to seven of the 13 pneumococcal serotypes in adults. If multiple vaccination is required before travel, deferring tetanus/diphtheria until after administering the

  3. Stýrinet: Nýsköpun innan Stjórnarráðsins. Nýtt verklag í samstarfi milli stjórnsýslustiga

    Directory of Open Access Journals (Sweden)

    Héðinn Unnsteinsson

    2012-06-01

    Full Text Available Í þessari grein er vakin athygli á nýju samskiptaformi sem er að ryðja sér til rúms innan stjórnsýslunnar með tilkomu stefnumörkunarinnar Ísland 2020. Stýrinet (e. governance network er hugtak sem æ fleiri fræðimenn og embættismenn hafa skoðað síðastliðin tíu ár sem mögulegan valkost við stigveldisstjórnsýslu og útvistaða stjórnsýslu, sem varð vinsæl í lok tíunda áratugarins með tilkomu nýsköpunar í ríkisrekstri (New Public Management. Samstarf þvert á ráðuneyti eru ekki ný af nálinni en með stefnuskjalinu Ísland 2020 eru sett fram verkefni sem krefjast annars konar vinnubragða en tíðkast hafa áður innan stjórnsýslunnar. Ísland 2020 hefur ýtt bæði undir samhentari stjórnsýslu með auknu samstarfi en krefst þess jafnframt að starfshópar starfi í anda stýrineta svo að sem mestur árangur megi verða af starfi þeirra. Í greininni er stýrinetskerfi, sem sett var upp innan Stjórnarráðsins og landshlutasamtaka í tengslum við sóknaráætlanir landshluta, skoðað. Tilraun er gerð til að meta hvort stýrinet séu betur til þess fallin en annars konar samstarf til að skila markvissari árangri við lausn verkefna.

  4. Use of Liquefied Biomethane (LBM) as a Vehicle Fuel for Road Freight Transportation : A Case Study Evaluating Environmental Performance of Using LBM for Operation of Tractor Trailers

    OpenAIRE

    Shanmugam, Kavitha; Tysklind, Mats; Upadhyayula, Venkata K.K.

    2018-01-01

    The environmental performance of Liquefied Biomethane (LBM) and Diesel operated Tractor Trailer (TT) is compared using the Life Cycle Assessment (LCA) study. In this study we consider, raw biogas produced from an anaerobic digestion process of a Wastewater Treatment Plant (WWTP) in Umea, Sweden, which is then upgraded and liquefied to LBM and used as a fuel for TTs. Currently, the WWTP in Umea is utilizing biogas, produced onsite for cogeneration of heat and electricity, thereby meeting its e...

  5. Effects of music tempo on performance, psychological, and physiological variables during 20 km cycling in well-trained cyclists.

    Science.gov (United States)

    2013-10-01

    Few studies have investigated the effects of music on trained athletes during high intensity endurance tasks. Therefore, this study investigated the effects of different music tempi on performance, psychological, and physiological responses of well-trained cyclists to time trial cycling. 10 male road cyclists (M age = 35 yr., SD = 7), with a minimum of three years racing experience, performed four 20-km time trials on a Computrainer Pro 3D indoor cycle trainer over a period of four weeks. The time-trials were spaced one week apart. The music conditions for each trial were randomised between fast-tempo (140 bpm), medium-tempo (120 bpm), slow-tempo (100 bpm), and no music. Performance (completion time, power output, average speed and cadence), physiological (heart rate, oxygen consumption, breathing frequency and respiratory exchange ratio), psychophysical (RPE), and psychological (mood states) data were collected for each trial. Results indicated no significant changes in performance, physiological, or psychophysical variables. Total mood disturbance and tension increased significantly in the fast-tempo trial when compared with medium and no-music conditions.

  6. Effects of ambient particulate matter on aerobic exercise performance

    Directory of Open Access Journals (Sweden)

    Dale R. Wagner

    2018-04-01

    Full Text Available Background/Objective: Wintertime thermal inversions in narrow mountain valleys create a ceiling effect, increasing concentration of small particulate matter (PM2.5. Despite potential health risks, many people continue to exercise outdoors in thermal inversions. This study measured the effects of ambient PM2.5 exposure associated with a typical thermal inversion on exercise performance, pulmonary function, and biological markers of inflammation. Methods: Healthy, active adults (5 males, 11 females performed two cycle ergometer time trials outdoors in a counterbalanced design: 1 low ambient PM2.5 concentrations ( .05 for PM2.5 concentration and the measured variables. Conclusion: An acute bout of vigorous exercise during an AQI of “yellow” did not diminish exercise performance in healthy adults, nor did it have a negative effect on pulmonary function or biological health markers. These variables might not be sensitive to small changes from acute, mild PM2.5 exposure. Keywords: Air pollution, Cycle ergometry, Pulmonary function, Time trial, Vigorous exercise

  7. Consecutive days of cold water immersion: effects on cycling performance and heart rate variability.

    Science.gov (United States)

    Stanley, Jamie; Peake, Jonathan M; Buchheit, Martin

    2013-02-01

    We investigated performance and heart rate (HR) variability (HRV) over consecutive days of cycling with post-exercise cold water immersion (CWI) or passive recovery (PAS). In a crossover design, 11 cyclists completed two separate 3-day training blocks (120 min cycling per day, 66 maximal sprints, 9 min time trialling [TT]), followed by 2 days of recovery-based training. The cyclists recovered from each training session by standing in cold water (10 °C) or at room temperature (27 °C) for 5 min. Mean power for sprints, total TT work and HR were assessed during each session. Resting vagal-HRV (natural logarithm of square-root of mean squared differences of successive R-R intervals; ln rMSSD) was assessed after exercise, after the recovery intervention, during sleep and upon waking. CWI allowed better maintenance of mean sprint power (between-trial difference [90 % confidence limits] +12.4 % [5.9; 18.9]), cadence (+2.0 % [0.6; 3.5]), and mean HR during exercise (+1.6 % [0.0; 3.2]) compared with PAS. ln rMSSD immediately following CWI was higher (+144 % [92; 211]) compared with PAS. There was no difference between the trials in TT performance (-0.2 % [-3.5; 3.0]) or waking ln rMSSD (-1.2 % [-5.9; 3.4]). CWI helps to maintain sprint performance during consecutive days of training, whereas its effects on vagal-HRV vary over time and depend on prior exercise intensity.

  8. Structure of the novel ternary hydrides Li4Tt2D (Tt=Si and Ge)

    International Nuclear Information System (INIS)

    Wu Hui; Rush, J.J.; Maryland Univ., College Park, MD; Hartman, M.R.; Oregon State Univ., Corvallis, OR; Udovic, T.J.; Zhou Wei; Pennsylvania Univ., Philadelphia, PA; Bowman, R.C. Jr.; Vajo, J.J.

    2007-01-01

    The crystal structures of newly discovered Li 4 Ge 2 D and Li 4 Si 2 D ternary phases were solved by direct methods using neutron powder diffraction data. Both structures can be described using a Cmmm orthorhombic cell with all hydrogen atoms occupying Li 6 -octahedral interstices. The overall crystal structure and the geometry of these interstices are compared with those of other related phases, and the stabilization of this novel class of ternary hydrides is discussed. (orig.)

  9. Complement Tense in Contrast: The <tt>SOT> parameter in Russian and English

    Directory of Open Access Journals (Sweden)

    Arnim von Stechow

    2010-12-01

    Full Text Available In an SOT-language like English, ‘past under past’ may have a simultaneous interpretation, i.e., we have temporal agreement. In a non-SOT language like Russian, we only have the shifted interpretation. In English, the temporal morphology of the embedded verb is determined by the matrix tense via a binding chain through verbal quantifiers such as ‘say’ or ‘think’. In Russian, these attitude verbs break the binding chain. The morphology of the embedded verb is determined locally by an embedded relative PRESENT, FUTURE or PAST. We propose that the difference between English and Russian is derived from: The SOT-parameter: A language L is an SOT-language if and only if the verbal quantifiers of L transmit temporal features. Verbal quantifiers quantify over times (e.g. fut. will or world-times (e.g. verba dicendi. The paper will take up a recent challenge by Daniel Altschuler and Olga Khomitsevich against existing accounts: verbs of perception and, occasionally, factive verbs in Russian may express simultaneity by ‘past under past’. We will show that the problem is in fact non-existent when the complement is imperfective. Concerning factives, however, we argue that the complement tense is an independent de re past. Finally, perception verbs are normally not verbal quantifiers and hence not subject to the SOT-parameter.

  10. The Supplementation of Branched-Chain Amino Acids, Arginine, and Citrulline Improves Endurance Exercise Performance in Two Consecutive Days

    Directory of Open Access Journals (Sweden)

    I-Shiung Cheng, Yi-Wen Wang, I-Fan Chen, Gi-Sheng Hsu, Chun-Fang Hsueh, Chen-Kang Chang

    2016-09-01

    Full Text Available The central nervous system plays a crucial role in fatigue during endurance exercise. Branched-chain amino acids (BCAA could reduce cerebral serotonin synthesis by competing with its precursor tryptophan for crossing the blood brain barrier. Arginine and citrulline could prevent excess hyperammonemia accompanied by BCAA supplementation. This study investigated the combination of BCAA, arginine, and citrulline on endurance performance in two consecutive days. Seven male and three female endurance runners ingested 0.17 g·kg-1 BCAA, 0.05 g·kg-1 arginine and 0.05 g·kg-1 citrulline (AA trial or placebo (PL trial in a randomized cross-over design. Each trial contained a 5000 m time trial on the first day, and a 10000 m time trial on the second day. The AA trial had significantly better performance in 5000 m (AA: 1065.7 ± 33.9 s; PL: 1100.5 ± 40.4 s and 10000 m (AA: 2292.0 ± 211.3 s; PL: 2375.6 ± 244.2 s. The two trials reported similar ratings of perceived exertion. After exercise, the AA trial had significantly lower tryptophan/BCAA ratio, similar NH3, and significantly higher urea concentrations. In conclusion, the supplementation could enhance time-trial performance in two consecutive days in endurance runners, possibly through the inhibition of cerebral serotonin synthesis by BCAA and the prevention of excess hyperammonemia by increased urea genesis.

  11. Relationship between physiological indices and aerobic performance tests in short and medium term of elite cyclists

    Directory of Open Access Journals (Sweden)

    Eduardo Bernardo Sangali

    2013-05-01

    Full Text Available Few studies allow usto verify which physiological responses are associated with performance in anational elite cycling group. Therefore, this study aimed to determine and correlate various physiological and aerobic indices with performance in 4 and 20 km time trials in high-level cyclists. The sample consisted of 14 male professional cyclists of the national elite group (28.5 ± 4.7 years old, 73.47 ± 8.29 kg, 176 ± 6.76cm, who performed a progressive test in laboratory to determine maximal oxygen consumption (VO2max: 62.23 ± 8.28 ml•kg-1•min-1, intensity relative to VO2max(iVO2max: 500.83 ± 58.65w, movement economy (EM: 0.1166 ± 0.0362 ml•kg•min•w-1, and the first and second ventilatory threshold (LV1: 348.21 ±43.26 w; LV2: 417.86 ± 60.79 w, respectively. They also performed two time trial performance tests of 4 and 20km. For the correlation between physiological indices and trial performance, Pearson correlation coefficient(p< 0.05 was used. No correlation was found between the physiological indices (VO2max absolute and relative, iVO2max, EM, LV1 and LV2 andperformance in 4 km (r= 0.38; 0.16; -0.33; 0.20; -0.50; -0.20, respectivelyand 20 km (r= 0.24; 0.01; -0.13; -0.12; -0.48; -0.19, respectively time trialin high level athletes. These results suggest that these variables are not able to explain the performance in time trials in the respective lengths, probably due to the subjects’ homogeneity.

  12. Translating Fatigue to Human Performance

    Science.gov (United States)

    Enoka, Roger M.; Duchateau, Jacques

    2016-01-01

    Despite flourishing interest in the topic of fatigue—as indicated by the many presentations on fatigue at the 2015 annual meeting of the American College of Sports Medicine—surprisingly little is known about its impact on human performance. There are two main reasons for this dilemma: (1) the inability of current terminology to accommodate the scope of the conditions ascribed to fatigue, and (2) a paucity of validated experimental models. In contrast to current practice, a case is made for a unified definition of fatigue to facilitate its management in health and disease. Based on the classic two-domain concept of Mosso, fatigue is defined as a disabling symptom in which physical and cognitive function is limited by interactions between performance fatigability and perceived fatigability. As a symptom, fatigue can only be measured by self-report, quantified as either a trait characteristic or a state variable. One consequence of such a definition is that the word fatigue should not be preceded by an adjective (e.g., central, mental, muscle, peripheral, and supraspinal) to suggest the locus of the changes responsible for an observed level of fatigue. Rather, mechanistic studies should be performed with validated experimental models to identify the changes responsible for the reported fatigue. As indicated by three examples (walking endurance in old adults, time trials by endurance athletes, and fatigue in persons with multiple sclerosis) discussed in the review, however, it has proven challenging to develop valid experimental models of fatigue. The proposed framework provides a foundation to address the many gaps in knowledge of how laboratory measures of fatigue and fatigability impact real-world performance. PMID:27015386

  13. Creatine Monohydrate Supplementation Does Not Augment Fitness, Performance, or Body Composition Adaptations in Response to Four Weeks of High-Intensity Interval Training in Young Females.

    Science.gov (United States)

    Forbes, Scott C; Sletten, Nathan; Durrer, Cody; Myette-Côté, Étienne; Candow, D; Little, Jonathan P

    2017-06-01

    High-intensity interval training (HIIT) has been shown to improve cardiorespiratory fitness, performance, body composition, and insulin sensitivity. Creatine (Cr) supplementation may augment responses to HIIT, leading to even greater physiological adaptations. The purpose of this study was to determine the effects of 4 weeks of HIIT (three sessions/week) combined with Cr supplementation in recreationally active females. Seventeen females (age = 23 ± 4 yrs; BMI = 23.4 ± 2.4) were randomly assigned to either Cr (Cr; 0.3 g・kg -1 ・d -1 for 5 d followed by 0.1 g・kg -1 ・d -1 for 23 days; n = 9) or placebo (PLA; n = 8). Before and after the intervention, VO 2peak , ventilatory threshold (VT), time-trial performance, lean body mass and fat mass, and insulin sensitivity were assessed. HIIT improved VO 2peak (Cr = +10.2%; PLA = +8.8%), VT (Cr = +12.7%; PLA = +9.9%), and time-trial performance (Cr = -11.5%; PLA = -11.6%) with no differences between groups (time main effects, all p body lean mass (Cr = +0.5%; PLA = -0.9%), or insulin resistance (Cr = +3.9%; PLA = +18.7%). In conclusion, HIIT is an effective way to improve cardiorespiratory fitness, VT, and time-trial performance. The addition of Cr to HIIT did not augment improvements in cardiorespiratory fitness, performance or body composition in recreationally active females.

  14. Citrus Flavonoid Supplementation Improves Exercise Performance in Trained Athletes

    Directory of Open Access Journals (Sweden)

    Elvera Overdevest, Jeroen A. Wouters, Kevin H.M. Wolfs, Job J.M. van Leeuwen, Sam Possemiers

    2018-03-01

    Full Text Available Previous studies have shown that polyphenol supplementation may be an effective strategy to improve exercise performance, due to their antioxidant character and ability to stimulate NO production. These properties may contribute to exercise performance, yet no conclusive research has been performed in exploring the direct effects of citrus flavonoids on human exercise performance. Therefore, the purpose of this study was to assess whether supplementation of a customized citrus flavonoid (CF extract for 4 weeks improves cycling time-trial performance in trained male athletes. In a double-blind, randomized, parallel study, 39 healthy, trained males were given a daily dose of either 500 mg of a customized citrus flavonoid extract (CF or a placebo for 4 weeks. Exercise performance was tested by means of a time-trial test on a cycle ergometer, during which participants had to generate as much power as possible for duration of 10 minutes. Absolute power output significantly increased with 14.9 ± 3.9 W after 4 weeks of CF supplementation, corresponding with a 5.0% increase, compared to 3.8 ± 3.2 W (1.3% increase in placebo (p < 0.05. In addition, oxygen consumption/power ratio significantly decreased in the CF group compared to placebo (p = 0.001, and a trend was found in the change in peak power output in CF (18.2 ± 23.2 W versus placebo (-28.4 ± 17.6 W; p = 0.116. The current study is the first convincing report that citrus flavonoid supplementation can improve exercise performance, as shown by a significant increase in power output during the exercise test.

  15. The effect of mountain bike wheel size on Cross-Country performance

    OpenAIRE

    Hurst, Howard Thomas; Atkins, Stephen; Metcalfe, John; Sinclair, Jonathan Kenneth; Rylands, Lee

    2016-01-01

    The purpose of this study was to determine the influence of different wheel size diameters on indicators of cross-country mountain bike time trial performance. Nine competitive male mountain bikers (age 34.7 ± 10.7 years; stature 177.7 ± 5.6 cm; body mass 73.2 ± 8.6 kg) performed 1 lap of a 3.48 km mountain bike (MTB) course as fast as possible on 26″, 27.5″ and 29″ wheeled MTB. Time (s), mean power (W), cadence (revs · min−1) and velocity (km · h−1) were recorded for the whole lap and during...

  16. Effect of thermal state and thermal comfort on cycling performance in the heat.

    Science.gov (United States)

    Schulze, Emiel; Daanen, Hein A M; Levels, Koen; Casadio, Julia R; Plews, Daniel J; Kilding, Andrew E; Siegel, Rodney; Laursen, Paul B

    2015-07-01

    To determine the effect of thermal state and thermal comfort on cycling performance in the heat. Seven well-trained male triathletes completed 3 performance trials consisting of 60 min cycling at a fixed rating of perceived exertion (14) followed immediately by a 20-km time trial in hot (30°C) and humid (80% relative humidity) conditions. In a randomized order, cyclists either drank ambient-temperature (30°C) fluid ad libitum during exercise (CON), drank ice slurry (-1°C) ad libitum during exercise (ICE), or precooled with iced towels and ice slurry ingestion (15 g/kg) before drinking ice slurry ad libitum during exercise (PC+ICE). Power output, rectal temperature, and ratings of thermal comfort were measured. Overall mean power output was possibly higher in ICE (+1.4%±1.8% [90% confidence limit]; 0.4> smallest worthwhile change [SWC]) and likely higher PC+ICE (+2.5%±1.9%; 1.5>SWC) than in CON; however, no substantial differences were shown between PC+ICE and ICE (unclear). Time-trial performance was likely enhanced in ICE compared with CON (+2.4%±2.7%; 1.4>SWC) and PC+ICE (+2.9%±3.2%; 1.9>SWC). Differences in mean rectal temperature during exercise were unclear between trials. Ratings of thermal comfort were likely and very likely lower during exercise in ICE and PC+ICE, respectively, than in CON. While PC+ICE had a stronger effect on mean power output compared with CON than ICE did, the ICE strategy enhanced late-stage time-trial performance the most. Findings suggest that thermal comfort may be as important as thermal state for maximizing performance in the heat.

  17. A systematic review on the herbal extract Tribulus terrestris and the roots of its putative aphrodisiac and performance enhancing effect.

    Science.gov (United States)

    Qureshi, Ahmed; Naughton, Declan P; Petroczi, Andrea

    2014-03-01

    Tribulus terrestris (TT) is a dicotyledonous herbal plant of the Zygophyllaceae family. In ancient medicine, extracts of the aerial parts and fruits have been used for its diuretic, tonic, and aphrodisiac properties. Today, TT is widely used by athletes and bodybuilders based on the belief, fueled by claims in marketing information, that it can enhance testosterone concentrations. To assess TT's effect on testosterone levels in human and animals, an electronic literature search out using seven databases and the patent database up to August 2013 was carried out. Randomized control trials, which included healthy human subjects ingesting TT as sole or combined supplement, along with animal studies with TT as a sole treatment across a number of species were included. Eleven studies met the inclusion criteria, including one patent application. The results showed that trials varied in duration, dosage and supplementation with TT as sole or combined treatment, rendering meta-analysis impossible. A limited number of animal studies displayed a significant increase in serum testosterone levels after TT administration, but this effect was only noted in humans when TT was part of a combined supplement administration. Literature available for the effectiveness of TT on enhancing testosterone concentrations is limited. Evidence to date suggests that TT is ineffective for increasing testosterone levels in humans, thus marketing claims are unsubstantiated. The nitric oxide release effect of TT may offer a plausible explanation for the observed physiological responses to TT supplementation, independent of the testosterone level.

  18. Relationships and Predictive Capabilities of Jump Assessments to Soccer-Specific Field Test Performance in Division I Collegiate Players.

    Science.gov (United States)

    Lockie, Robert G; Stage, Alyssa A; Stokes, John J; Orjalo, Ashley J; Davis, DeShaun L; Giuliano, Dominic V; Moreno, Matthew R; Risso, Fabrice G; Lazar, Adrina; Birmingham-Babauta, Samantha A; Tomita, Tricia M

    2016-12-03

    Leg power is an important characteristic for soccer, and jump tests can measure this capacity. Limited research has analyzed relationships between jumping and soccer-specific field test performance in collegiate male players. Nineteen Division I players completed tests of: leg power (vertical jump (VJ), standing broad jump (SBJ), left- and right-leg triple hop (TH)); linear (30 m sprint; 0⁻5 m, 5⁻10 m, 0⁻10, 0⁻30 m intervals) and change-of-direction (505) speed; soccer-specific fitness (Yo-Yo Intermittent Recovery Test Level 2); and 7 × 30-m sprints to measure repeated-sprint ability (RSA; total time (TT), performance decrement (PD)). Pearson's correlations ( r ) determined jump and field test relationships; stepwise regression ascertained jump predictors of the tests ( p jumps correlated with the 0⁻5, 0⁻10, and 0⁻30 m sprint intervals ( r = -0.65⁻-0.90). VJ, SBJ, and left- and right-leg TH correlated with RSA TT ( r = -0.51⁻-0.59). Right-leg TH predicted the 0⁻5 and 0⁻10 m intervals (R² = 0.55⁻0.81); the VJ predicted the 0⁻30 m interval and RSA TT (R² = 0.41⁻0.84). Between-leg TH asymmetry correlated with and predicted left-leg 505 and RSA PD ( r = -0.68⁻0.62; R² = 0.39⁻0.46). Improvements in jumping ability could contribute to faster speed and RSA performance in collegiate soccer players.

  19. Relationships and Predictive Capabilities of Jump Assessments to Soccer-Specific Field Test Performance in Division I Collegiate Players

    Directory of Open Access Journals (Sweden)

    Robert G. Lockie

    2016-12-01

    Full Text Available Leg power is an important characteristic for soccer, and jump tests can measure this capacity. Limited research has analyzed relationships between jumping and soccer-specific field test performance in collegiate male players. Nineteen Division I players completed tests of: leg power (vertical jump (VJ, standing broad jump (SBJ, left- and right-leg triple hop (TH; linear (30 m sprint; 0–5 m, 5–10 m, 0–10, 0–30 m intervals and change-of-direction (505 speed; soccer-specific fitness (Yo-Yo Intermittent Recovery Test Level 2; and 7 × 30-m sprints to measure repeated-sprint ability (RSA; total time (TT, performance decrement (PD. Pearson’s correlations (r determined jump and field test relationships; stepwise regression ascertained jump predictors of the tests (p < 0.05. All jumps correlated with the 0–5, 0–10, and 0–30 m sprint intervals (r = −0.65–−0.90. VJ, SBJ, and left- and right-leg TH correlated with RSA TT (r = −0.51–−0.59. Right-leg TH predicted the 0–5 and 0–10 m intervals (R2 = 0.55–0.81; the VJ predicted the 0–30 m interval and RSA TT (R2 = 0.41–0.84. Between-leg TH asymmetry correlated with and predicted left-leg 505 and RSA PD (r = −0.68–0.62; R2 = 0.39–0.46. Improvements in jumping ability could contribute to faster speed and RSA performance in collegiate soccer players.

  20. The effect of post-exercise hydrotherapy on subsequent exercise performance and heart rate variability.

    Science.gov (United States)

    Stanley, Jamie; Buchheit, Martin; Peake, Jonathan M

    2012-03-01

    We investigated the effect of hydrotherapy on time-trial performance and cardiac parasympathetic reactivation during recovery from intense training. On three occasions, 18 well-trained cyclists completed 60 min high-intensity cycling, followed 20 min later by one of three 10-min recovery interventions: passive rest (PAS), cold water immersion (CWI), or contrast water immersion (CWT). The cyclists then rested quietly for 160 min with R-R intervals and perceptions of recovery recorded every 30 min. Cardiac parasympathetic activity was evaluated using the natural logarithm of the square root of mean squared differences of successive R-R intervals (ln rMSSD). Finally, the cyclists completed a work-based cycling time trial. Effects were examined using magnitude-based inferences. Differences in time-trial performance between the three trials were trivial. Compared with PAS, general fatigue was very likely lower for CWI (difference [90% confidence limits; -12% (-18; -5)]) and CWT [-11% (-19; -2)]. Leg soreness was almost certainly lower following CWI [-22% (-30; -14)] and CWT [-27% (-37; -15)]. The change in mean ln rMSSD following the recovery interventions (ln rMSSD(Post-interv)) was almost certainly higher following CWI [16.0% (10.4; 23.2)] and very likely higher following CWT [12.5% (5.5; 20.0)] compared with PAS, and possibly higher following CWI [3.7% (-0.9; 8.4)] compared with CWT. The correlations between performance, ln rMSSD(Post-interv) and perceptions of recovery were unclear. A moderate correlation was observed between ln rMSSD(Post-interv) and leg soreness [r = -0.50 (-0.66; -0.29)]. Although the effects of CWI and CWT on performance were trivial, the beneficial effects on perceptions of recovery support the use of these recovery strategies.

  1. Relationship Between Jumping Ability, Agility and Sprint Performance of Elite Young Basketball Players: A Field-Test Approach

    OpenAIRE

    Abbas Asadi

    2016-01-01

    DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n2p177   The purpose of this study was to determine the relationships between sprint, agility and jump performance of elite young basketball players. Sixteen elite national level young male basketball players participated in this study. The jumping ability of each player was determined using countermovement jump (CMJ), and broad long jump (BLJ). The agility T test (TT) and Illinois agility test (IAT) were assessed to determine the agilit...

  2. Reviews Equipment: Time Trial R/C Race Track Timer Book: A Universe from Nothing Equipment: Locktronics Electronics, Magnestism and Materials Unit Report: Nuclear Physics and Technology Book: Particle Physics Booklet: Radiation and You Book: The Million Death Quake Web Watch

    Science.gov (United States)

    2013-03-01

    WE RECOMMEND Locktronics Electronics, Magnestism and Materials Unit Robust, reliable and proven classroom kit The Million Death Quake: the Science of Predicting the Earth's Deadliest Natural Disaster Accessible and well-written book covers everything you might (and perhaps should) want to know about earthquakes WORTH A LOOK Time Trial R/C Race Track Timer Fun kit for use with toy cars but little flexibility for other uses A Universe From Nothing: Why There is Something Rather Than Nothing Up-to-date account of cosmology explains very well but becomes polemical and loses focus Nuclear physics and technology—inside the atom IOP report useful for students considering a career in physics Particle Physics: A Very Short Introduction Passages of good writing undermined by editing as the structure and illustrations disappoint Radiation and You Report is an interesting insight into radiation information from 25 years back, but some errors and a slow start let it down WEB WATCH App that aids star identification is highly recommended and videos for students and teachers also make the grade

  3. Utveckling av riktningsanalys exergiberäkningar i Luleå och Strängnäs kommuner eller Hur kan man veta om man hushållar med resurserna på ett hållbart sätt?

    OpenAIRE

    Delin, Staffan; Gundelius, Eva

    1998-01-01

    Bakgrunden till projektet är den riktningsanalys som utvecklades av Eva Grundelius år 1991. Riktningsanalysen som är uppbyggd kring sex frågor fungerar som en checklista för hållbar utveckling. Den kan användas i många slag av beslutssituationer. För att göra riktningsanalysen mer operativ och kvantifierbar har den i detta projekt kopplats samman med en exergianalys. Exergi är ett fysiskt mått på resursers värde. Denna analys görs med utgångspunkt från det livsuppehållande systemet, ekosystem...

  4. Environmental Performance

    DEFF Research Database (Denmark)

    Svabo, Connie; Lindelof, Anja Mølle

    from the perspective of time and liveness as experienced in art on environmental performance discussing how environmental performances frame the temporality of the world. The paper engages with contemporary examples of environmental performances from various disciplines (sound, video, television...

  5. b型流感嗜血杆菌结合疫苗接种后婴幼儿安全性和免疫原性研究%Safety and immunogenicity in 3-5 months-old infants after primary and boosting immunization with Hib PRP-TT conjugate vaccine

    Institute of Scientific and Technical Information of China (English)

    叶强; 谢贵林; 李亚南; 赵志强; 李荣成; 何莉; 谭晓梅; 李艳萍; 杜送田; 李凤祥

    2012-01-01

    目的 评价b型流感嗜血杆菌结合疫苗(Hib-TT)安全性和免疫原性.方法 分别采用Hib-TT试验疫苗和对照疫苗3针免疫接种3~5月龄婴幼儿,观察疫苗安全性,并采用定量ELISA法分别测定免疫前、免疫后和加强免疫后血清特异性IgG抗体浓度.结果 实验疫苗和对照疫苗两组间不良反应总发生率(实验疫苗组为23.85%,对照疫苗组为31.40%)差异无统计学意义(x2=0.5,P>0.05),发热性总不良反应率分别为22.3%和31.3%,中、强发热反应率分别为3.67%和4.48%,差异无统计学意义;实验疫苗受试者局部红、肿、硬结等不良反应率为1.22%.实验疫苗3剂免疫后受试者血清抗Hib PRP IgG抗体平均几何浓度(GMC)为6.6786 μg/ml,对照疫苗组血清抗体GMC为7.5346 μg/ml,两组间抗体GMC差异无统计学意义(x2=0.147,P=0.702);加强免疫1剂后,实验疫苗组受试者血清抗体GMC从加强免疫前的2.6396 μg/ml上升为6.2044μg/ml.结论 实验疫苗接种3~5月龄婴幼儿具有良好的安全性.用间隔1个月、3剂次接种的基础免疫程序能诱导该年龄组受试者产生长期保护水平的血清特异性抗体,加强免疫1剂后能诱导机体产生免疫记忆反应.%Objectives To evaluate the safety and immunogenicity of Haemophilus influenzae type b capsular-tetanus toxoid(Hib-TT) conjugate vaccine.Methods In an open-controlled,randomized trial,the eligible and consented infants of 3 to 5 months-old received 3 doses of Hib-TT or a licensed Hib-TT conjugate vaccine(Anerbao) as the control vaccine to evaluate safety; The serum anti-Hib PRP IgG antibody mean geometric concentration (GMC) in both groups after primary and boosting vaccination were measured by ELISA.Results No apparent difference in the frequency of total adverse reactions observed between two groups (study vaccine 23.85% vs.comparator 31.40%) (x2=0.5,P>0.05).The mild and severe fever reaction of both vaccines was 3.67% and 4

  6. The Effects of a Multi-Ingredient Performance Supplement on Hormonal Profiles and Body Composition in Male College Athletes

    Directory of Open Access Journals (Sweden)

    Matthew H. Sharp

    2016-05-01

    Full Text Available Periods of intense training can elicit an acute decline in performance and body composition associated with weakened hormone profiles. This study investigated the effects of a multi-ingredient performance supplement (MIPS on body composition and hormone levels in college athletes following a six-week training protocol. Twenty male college athletes were equally assigned to MIPS and placebo (PLA groups for supplementation (three pills, twice daily in conjunction with resistance training and specialized sports training (e.g., nine total sessions/week for six weeks. Dual Energy X-ray Absorptiometry determined body composition at weeks 0 and 6. Serum samples collected at weeks 0 and 6 determined free testosterone (FT, total testosterone (TT, IGF-1 and total estrogen (TE levels. PLA experienced a significant decline in lean body mass (LBM (−1.5 kg; p < 0.05 whereas the MIPS sustained LBM. The MIPS increased TT 21.9% (541.5 ± 48.7 to 639.1 ± 31.7 and increased FT 15.2% (13.28 ± 1.1 to 15.45 ± 1.3 ng/dL (p < 0.05. Conversely, PLA decreased TT 7.9% (554.5 ± 43.3 to 497.2 ± 39.1 ng/dL, decreased FT 17.4% (13.41 ± 1.8 to 11.23 ± 2.55 ng/dL, and decreased FT:E 12.06% (p < 0.05. These findings suggest the MIPS can prevent decrements in LBM and anabolic hormone profiles during intense training periods.

  7. Whey or Casein Hydrolysate with Carbohydrate for Metabolism and Performance in Cycling.

    Science.gov (United States)

    Oosthuyse, T; Carstens, M; Millen, A M E

    2015-07-01

    The protein type most suitable for ingestion during endurance exercise is undefined. This study compared co-ingestion of either 15 g/h whey or casein hydrolysate with 63 g/h fructose: maltodextrin (0.8:1) on exogenous carbohydrate oxidation, exercise metabolism and performance. 2 h postprandial, 8 male cyclists ingested either: carbohydrate-only, carbohydrate-whey hydrolysate, carbohydrate-casein hydrolysate or placebo-water in a crossover, double-blind design during 2 h of exercise at 60%W max followed by a 16-km time trial. Data were evaluated by magnitude-based inferential statistics. Exogenous carbohydrate oxidation, measured from (13)CO2 breath enrichment, was not substantially influenced by co-ingestion of either protein hydrolysate. However, only co-ingestion of carbohydrate-casein hydrolysate substantially decreased (98% very likely decrease) total carbohydrate oxidation (mean±SD, 242±44; 258±47; 277±33 g for carbohydrate-casein, carbohydrate-whey and carbohydrate-only, respectively) and substantially increased (93% likely increase) total fat oxidation (92±14; 83±27; 73±19 g) compared with carbohydrate-only. Furthermore, only carbohydrate-casein hydrolysate ingestion resulted in a faster time trial (-3.6%; 90% CI: ±3.2%) compared with placebo-water (95% likely benefit). However, neither protein hydrolysate enhanced time trial performance when compared with carbohydrate-only. Under the conditions of this study, ingesting carbohydrate-casein, but not carbohydrate-whey hydrolysate, favourably alters metabolism during prolonged moderate-strenuous cycling without substantially altering cycling performance compared with carbohydrate-only. © Georg Thieme Verlag KG Stuttgart · New York.

  8. Coinciding exercise with peak serum caffeine does not improve cycling performance.

    Science.gov (United States)

    Skinner, Tina L; Jenkins, David G; Taaffe, Dennis R; Leveritt, Michael D; Coombes, Jeff S

    2013-01-01

    To investigate whether coinciding peak serum caffeine concentration with the onset of exercise enhances subsequent endurance performance. Randomised, double-blind, crossover. In this randomised, placebo-controlled, double-blind crossover study, 14 male trained cyclists and triathletes (age 31±5year, body mass 75.4±5.7 kg, VO₂max 69.5±6.1 mL kg⁻¹ min⁻¹ and peak power output 417±35W, mean±SD) consumed 6 mg kg(-1) caffeine or a placebo either 1h (C(1h)) prior to completing a 40 km time trial or when the start of exercise coincided with individual peak serum caffeine concentrations (C(peak)). C(peak) was determined from a separate 'caffeine profiling' session that involved monitoring caffeine concentrations in the blood every 30 min over a 4h period. Following caffeine ingestion, peak serum caffeine occurred 120 min in 12 participants and 150 min in 2 participants. Time to complete the 40 km time trial was significantly faster (2.0%; p=0.002) in C(1h) compared to placebo. No statistically significant improvement in performance was noted in the C(peak) trial versus placebo (1.1%; p=0.240). Whilst no differences in metabolic markers were found between C(peak) and placebo conditions, plasma concentrations of glucose (p=0.005), norepinephrine and epinephrine (p≤0.002) were higher in the C(1h) trial 6 min post-exercise versus placebo. In contrast to coinciding peak serum caffeine concentration with exercise onset, caffeine consumed 60 min prior to exercise resulted in significant improvements in 40 km time trial performance. The ergogenic effect of caffeine was not found to be related to peak caffeine concentration in the blood at the onset of endurance exercise. Copyright © 2012 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  9. Performance of the Helium Circulation System on a Commercialized MEG

    International Nuclear Information System (INIS)

    Takeda, T; Miyazaki, T; Okamoto, M; Katagiri, K

    2012-01-01

    We report the performance of a helium circulation system (HCS) mounted on a MEG (Magnetoencephalography) at Nagoya University, Japan. This instrument is the first commercialized version of an HCS. The HCS collects warm helium gas at approximately 300 K and then cools it to approximately 40 K. The gas is returned to the neck tube of a Dewar of the MEG to keep it cold. It also collects helium gas in the region just above the liquid helium surface while it is still cold, re-liquefies the gas and returns it to the Dewar. A special transfer tube (TT) of approximately 3 m length was developed to allow for dual helium streams. This tube separates the HCS using a MEG to reduce magnetic noise. A refiner was incorporated to effectively collect contaminating gases by freezing them. The refiner was equipped with an electric heater to remove the frozen contaminants as gases into the air. A gas flow controller was also developed, which automatically controlled the heater and electric valves to clean up contamination. The developed TT exhibited a very low heat inflow of less than 0.1 W/m to the liquid helium, ensuring efficient operation. The insert tube diameter, which was 1.5 in. was reduced to a standard 0.5 in. size. This dimensional change enabled the HCS to mount onto any commercialized MEG without any modifications to the MEG. The HCS can increase liquid helium in the Dewar by at least 3 liters/Day using two GM cryocoolers (SRDK-415D, Sumitomo Heavy Industries, Ltd.). The noise levels were virtually the same as before this installation.

  10. Measurement of Normalized Differential Cross Section for the tt̄ Production in the Dilepton Channel in pp Collisions at a center-of-mass energy of 13 TeV

    Directory of Open Access Journals (Sweden)

    Jeon Dajeong

    2017-01-01

    Full Text Available Differential cross sections of top-quark pair production as function of the kinematic variables of leptons, b-jets and top-quarks at particle level are measured in the dilepton decay channel with proton-proton collisions at a center-of-mass energy of 13 TeV. The measurements are performed with Run II data using the CMS detector at the Large Hadron Collider.

  11. Environmental Performance

    DEFF Research Database (Denmark)

    Lindelof, Anja Mølle; Schmidt, Ulrik; Svabo, Connie

    2017-01-01

    Do ants and grasshoppers perform? Do clouds, plants and melting ice? Do skyscrapers, traffic jams and computer vira? And what happens to our understanding of liveness if that is the case? This chapter takes ongoing theoretical disputes about the nature of live performance in performance studies...... as its starting point to investigate liveness within a specific kind of contemporary performance: ‘environmental performances’. Environmental performances are arts practices that take environmental processes as their focus by framing activities of non-human performers such as clouds, wind and weeds - key...

  12. Performing Identities

    DEFF Research Database (Denmark)

    von Wallpach, Sylvia; Hemetsberger, Andrea; Espersen, Peter

    2017-01-01

    performative approaches to branding, this study applies a performativity theory perspective. Brand performances—encompassing playing and liking, basement building and showcasing, creating and innovating, community building and facilitating, storytelling, missionizing, and marketplace developing—exhibit generic...

  13. Dj Performance

    DEFF Research Database (Denmark)

    Dj Performance at a late concert at The Hub, Plymouth, in support of Sileni, Superconductor and others.......Dj Performance at a late concert at The Hub, Plymouth, in support of Sileni, Superconductor and others....

  14. Performance analysis

    International Nuclear Information System (INIS)

    2008-05-01

    This book introduces energy and resource technology development business with performance analysis, which has business division and definition, analysis of current situation of support, substance of basic plan of national energy, resource technique development, selection of analysis index, result of performance analysis by index, performance result of investigation, analysis and appraisal of energy and resource technology development business in 2007.

  15. Performative Work

    DEFF Research Database (Denmark)

    Beunza, Daniel; Ferraro, Fabrizio

    2018-01-01

    by attending to the normative and regulative associations of the device. We theorize this route to performativity by proposing the concept of performative work, which designates the necessary institutional work to enable translation and the subsequent adoption of the device. We conclude by considering...... the implications of performative work for the performativity and the institutional work literatures.......Callon’s performativity thesis has illuminated how economic theories and calculative devices shape markets, but has been challenged for its neglect of the organizational, institutional and political context. Our seven-year qualitative study of a large financial data company found that the company...

  16. The SEMA5A gene is associated with hippocampal volume, and their interaction is associated with performance on Raven's Progressive Matrices.

    Science.gov (United States)

    Zhu, Bi; Chen, Chuansheng; Xue, Gui; Moyzis, Robert K; Dong, Qi; Chen, Chunhui; Li, Jin; He, Qinghua; Lei, Xuemei; Wang, Yunxin; Lin, Chongde

    2014-03-01

    The Allen Brain Atlas shows that the semaphorin 5A (SEMA5A) gene, which encodes an important protein for neurogenesis and neuronal apoptosis, is predominantly expressed in the human hippocampus. Structural and functional neuroimaging studies have further shown that the hippocampus plays an important role in the performance on Raven's Progressive Matrices (RPM), a measure of reasoning ability and general fluid intelligence. Thus far, however, no study has examined the relationships between the SEMA5A gene polymorphism, hippocampal volume, and RPM performance. The current study collected both structural MRI, genetic, and behavioral data in 329 healthy Chinese adults, and examined associations between SEMA5A variants, hippocampal volume, and performance on RAPM (the advanced form of RPM). After controlling for intracranial volume (ICV), sex, and age, SEMA5A genetic polymorphism at the SNP rs42352 had the strongest association with hippocampal volume (p=0.00000552 and 0.000103 for right and left hippocampal volumes, respectively), with TT homozygotes having higher hippocampal volume than the other genotypes. Furthermore, there was a high correlation between right hippocampal volume and RAPM performance (r=0.42, p=0.0000509) for SEMA5A rs42352 TT homozygotes. This study provides the first evidence for the involvement of the SEMA5A gene in hippocampal structure and their interaction on RAPM performance. Future studies of the hippocampus-RPM associations should consider genetic factors as potential moderators. Copyright © 2013 Elsevier Inc. All rights reserved.

  17. Effect of diet supplementation with live yeast Saccharomyces cerevisiae on growth performance, caecal ecosystem and health of growing rabbits

    Directory of Open Access Journals (Sweden)

    T. Belhassen

    2016-09-01

    Full Text Available The aim of this study was to determine the effect of the live yeast Saccharomyces cerevisiae on the growth performance, caecal ecosystem and overall health of growing rabbits. A control diet was formulated (crude protein: 15.9%; neutral detergent fibre: 31.6% and another diet obtained by supplementing the control diet with 1 g of Saccharomyces cerevisiae (6.5×109 colony-forming units per kg of diet. Ninety 35-d old rabbits were allotted into 3 groups: TT (rabbits offered the supplemented diet from 17 d of age onwards, CT (rabbits offered supplemented diet from 35 d and CC (rabbits fed non-supplemented diet. Body weight (BW and feed intake were measured weekly and mortality was controlled daily. At 35, 42 and 77 d of age, 6 rabbits from each group were slaughtered and digestive physiological traits, serum clinical chemistry parameters, fermentation traits, and the composition of caecal microbiota examined. At 42 and 56 d of age, 10 rabbits from each group were injected intraperitoneally with 100 μg/animal of ovalbumin and blood samples were collected for examination of plasma immunological parameters. Throughout the experiment (5-11 wk, weight gain and feed intake (37.8 and 112.6 g/d, on av. were not affected by yeast, except for weight gain in the first week after weaning, which was the highest in TT animals among the 3 groups (48.1 vs. 43.9 and 44.2 g/d for TT, CC and CT, respectively; P=0.012. This may be due to the increased trend in feed intake (P=0.072 in the TT group (96.4 g/d compared to the others. Mortality (5/90 was low and did not differ among the 3 groups. Treatments had no effect on slaughter traits at the 3 sampling dates (35, 42 and 77 d. Only the weight of the empty caecum (% BW was higher (P=0.02 in CC (2.2% and CT (2.3% than in TT group (1.8% at 77 d of age. Treatments did not overtly affect the caecal microbiota, although the number of total anaerobic bacteria and Bacteroides were lower (108 and 107/g caecal digesta

  18. The ergogenic effect of beta-alanine combined with sodium bicarbonate on high-intensity swimming performance.

    Science.gov (United States)

    Painelli, Vitor de Salles; Roschel, Hamilton; Jesus, Flávia de; Sale, Craig; Harris, Roger Charles; Solis, Marina Yázigi; Benatti, Fabiana Braga; Gualano, Bruno; Lancha, Antonio Herbert; Artioli, Guilherme Giannini

    2013-05-01

    We investigated the effect of beta-alanine (BA) alone (study A) and in combination with sodium bicarbonate (SB) (study B) on 100- and 200-m swimming performance. In study A, 16 swimmers were assigned to receive either BA (3.2 g·day(-1) for 1 week and 6.4 g·day(-1) for 4 weeks) or placebo (PL; dextrose). At baseline and after 5 weeks of supplementation, 100- and 200-m races were completed. In study B, 14 were assigned to receive either BA (3.2 g·day(-1) for 1 week and 6.4 g·day(-1) for 3 weeks) or PL. Time trials were performed once before and twice after supplementation (with PL and SB), in a crossover fashion, providing 4 conditions: PL-PL, PL-SB, BA-PL, and BA-SB. In study A, BA supplementation improved 100- and 200-m time-trial performance by 2.1% (p = 0.029) and 2.0% (p = 0.0008), respectively. In study B, 200-m time-trial performance improved in all conditions, compared with presupplementation, except the PL-PL condition (PL-SB, +2.3%; BA-PL, +1.5%; BA-SB, +2.13% (p < 0.05)). BA-SB was not different from BA-PL (p = 0.21), but the probability of a positive effect was 78.5%. In the 100-m time-trial, only a within-group effect for SB was observed in the PL-SB (p = 0.022) and BA-SB (p = 0.051) conditions. However, 6 of 7 athletes swam faster after BA supplementation. The probability of BA having a positive effect was 65.2%; when SB was added to BA, the probability was 71.8%. BA and SB supplementation improved 100- and 200-m swimming performance. The coingestion of BA and SB induced a further nonsignificant improvement in performance.

  19. Associated Top-Quark-Pair and b-Jet Production in the Dilepton Channel at $\\sqrt{s}$ = 8 TeV as Test of QCD and Background to tt+Higgs Production

    CERN Document Server

    Bartosik, Nazar

    2015-08-26

    Two technical and two physics analyses are reported in this thesis, which were√carried out using data recorded by CMS at s = 8 TeV. The first technical contribution is related to the improvement of the performance of the CMS tracking detector,which provides measurements of trajectories of charged particles, and is relevant fornearly every physics analysis at CMS. A new method was studied for Lorentz-angleestimation and correction for the lost signal due to the short readout time betweensubsequent proton-bunch crossings. Such parameters are determined simultaneouslywith the tracker geometry, which allows to include correlations between different effects and to even absorb unknown or mismodelled ones. The obtained results showan improvement of hit-position resolution, which is more stable in time comparedto standalone measurements. Possible ways of further improvement of the methodare also proposed.In the second technical contribution, a standalone software package was developed for the identification of t...

  20. ITER task title - source term data, modelling, and analysis. ITER subtask no. S81TT05/5 (SEP 1-1). Global tritium source term analysis basis document. Subtask 1: operational tritium effluents and releases. Final report (1995 TASK)

    International Nuclear Information System (INIS)

    Kalyanam, K.M.

    1996-06-01

    This document represents the final report for the global tritium source term analysis task initiated in 1995. The report presents a room-by-room map/table at the subsystem level for the ITER tritium systems, identifying the major equipment, secondary containments, tritium release sources, duration/frequency of tritium releases and the release pathways. The chronic tritium releases during normal operation, as well as tritium releases due to routine maintenance of the Water Distillation Unit, Isotope Separation System and Primary and Secondary Heat Transport Systems, have been estimated for most of the subsystems, based on the IDR design, the Design Description Documents (April - Jun 1995 issues) and the design updates up to December 1995. The report also outlines the methodology and the key assumptions that are adopted in preparing the tritium release estimates. The design parameters for the ITER Basic Performance Phase (BPP) have been used in estimating the tritium releases shown in the room-by-room map/table. The tritium release calculations and the room-by-room map/table have been prepared in EXCEL, so that the estimates can be refined easily as the design evolves and more detailed information becomes available. (author). 23 refs., tabs

  1. Mixed drink increased carbohydrate oxidation but not performance ...

    African Journals Online (AJOL)

    ... improvement in 40 km time trial time between an isocaloric GP-only or a GP and fructose drink, and no differences in any of the measured variables other than exogenous carbohydrate oxidation at 90 minutes during the pre-time trial steady state ride. Keywords: multiple carbohydrate, cycling, endurance, glucose, fructose ...

  2. Critical determinants of combined sprint and endurance performance: an integrative analysis from muscle fiber to the human body.

    Science.gov (United States)

    van der Zwaard, Stephan; van der Laarse, Willem J; Weide, Guido; Bloemers, Frank W; Hofmijster, Mathijs J; Levels, Koen; Noordhof, Dionne A; de Koning, Jos J; de Ruiter, Cornelis J; Jaspers, Richard T

    2018-04-01

    Optimizing physical performance is a major goal in current physiology. However, basic understanding of combining high sprint and endurance performance is currently lacking. This study identifies critical determinants of combined sprint and endurance performance using multiple regression analyses of physiologic determinants at different biologic levels. Cyclists, including 6 international sprint, 8 team pursuit, and 14 road cyclists, completed a Wingate test and 15-km time trial to obtain sprint and endurance performance results, respectively. Performance was normalized to lean body mass 2/3 to eliminate the influence of body size. Performance determinants were obtained from whole-body oxygen consumption, blood sampling, knee-extensor maximal force, muscle oxygenation, whole-muscle morphology, and muscle fiber histochemistry of musculus vastus lateralis. Normalized sprint performance was explained by percentage of fast-type fibers and muscle volume ( R 2 = 0.65; P body.

  3. Gender & performance

    NARCIS (Netherlands)

    Röttger, K.; Buchheim, E.; Groot, M.; Jonker, E.; Müller-Schirmer, A.; de Vos, M.; Walhout, E.; van der Zande, H.

    2012-01-01

    This Yearbook for Women’s History (Jaarboek voor Vrouwengeschiedenis) examines the theme of gender and performance. It is supervised by guest editor Kati Röttger, professor in Theatre Studies at the University of Amsterdam. The term performance - a temporary and active presentation, expression, or

  4. Performing compliance

    DEFF Research Database (Denmark)

    Wimmelmann, Camilla Lawaetz

    2017-01-01

    the local policy workers front-staged some practices in the implementation process and back-staged others. The local policy workers deliberately performed ‘guideline compliance’ by using information control and impression management techniques. The findings suggest that local guideline compliance should...... be regarded as a staged performance in which deliberate techniques are used to produce and manage certain impressions of compliance....

  5. School Performance

    Science.gov (United States)

    Lamas, Héctor A.

    2015-01-01

    The school performance study of students is, due to its relevance and complexity, one of the issues of major controversy in the educational research, and it has been given special attention in the last decades. This study is intended to show a conceptual approach to the school performance construct, contextualizing the reality in the regular basic…

  6. Associated top-quark-pair and b-jet production in the dilepton channel at √(s)=8 TeV as test of QCD and background to tt+Higgs production

    International Nuclear Information System (INIS)

    Bartosik, Nazar

    2015-08-01

    Two technical and two physics analyses are reported in this thesis, which were carried out using data recorded by CMS at √(s)=8 TeV. The first technical contribution is related to the improvement of the performance of the CMS tracking detector, which provides measurements of trajectories of charged particles, and is relevant for nearly every physics analysis at CMS. A new method was studied for Lorentz-angle estimation and correction for the lost signal due to the short readout time between subsequent proton-bunch crossings. Such parameters are determined simultaneously with the tracker geometry, which allows to include correlations between different effects and to even absorb unknown or mismodelled ones. The obtained results show an improvement of hit-position resolution, which is more stable in time compared to standalone measurements. Possible ways of further improvement of the method are also proposed. In the second technical contribution, a standalone software package was developed for the identification of the origin of jets initiated by bottom quarks (b jets) in Monte Carlo (MC) simulations. It allows to differentiate at generator level between b jets originating from decays of e.g. a top-quark, or a Higgs boson, or a Z boson, based on the actual particle relations stored in the simulated event. This functionality is crucial for the presented physics analyses, and it did not exist in CMS before. Its generic implementation provides equally high performance with all parton-shower generators that are used at CMS, and was chosen as a recommended way of heavy-flavour-jet definition in future CMS analyses. As one of the primary results of this thesis, the cross sections of top-quark-pair production in association with at least one (t anti tb(anti b)) or at least two (t anti tb anti b) b jets with p T >20 GeV were measured differentially as functions of transverse momentum (p T ) and absolute pseudorapidity (vertical stroke η vertical stroke) of the first or the

  7. Aesthetic Performance

    DEFF Research Database (Denmark)

    Landgrebe, Jeanette

    2013-01-01

    -verbal actions, gaze orientation, active and static interactional strategies and props. From the data investigated, it seems that the performance act is divided into different stages which each calls for different strategies: the group's initiation of the entire performance act reveals that the group stand out......This article deals with how an aesthetic performance is enacted and coordinated by a performance group attracting attention and engaging commuters in a public space. Multimodal interactional resources and the way they are coordinated by interactants are investigated, and include verbal and non...... as uncoordinated and it may have a significance for whether the 'street' performers manage to stay in character or not. Once attention from commuters is obtained, a continued gaze from these commuters opens up for subsequent interaction, which then ultimately may result in the successful handing over of a card...

  8. Organizational Performance

    Directory of Open Access Journals (Sweden)

    Renata Peregrino de Brito

    2016-01-01

    Full Text Available This paper presents a theoretical and empirical analysis of the relationship between human resource management (HRM and organizational performance. Theoretically, we discuss the importance of HRM for the development of resources and its impact on business performance. Empirically, we evaluated articles published on Brazilian academic journals that addressed such relationships. The results showed a lack of studies conducted at this intersection. From the universe of 2,469 articles, only 16 (0.6% sought to relate HRM and organizational performance. We observed a dominance of isolated HR practices, which does not consider HRM as a system, and of operational performance measures, relative to financial and efficiency variables. Most studies show a positive relationship between HRM practices and performance, in line with the literature. However, we point out some methodological issues, such as the difficulty of isolating the HR practices from its context, the failure to consider the temporality of this relationship, and the comparison between companies from different industries.

  9. School Performance

    Directory of Open Access Journals (Sweden)

    Héctor A. Lamas

    2015-03-01

    Full Text Available The school performance study of students is, due to its relevance and complexity, one of the issues of major controversy in the educational research, and it has been given special attention in the last decades. This study is intended to show a conceptual approach to the school performance construct, contextualizing the reality in the regular basic education classrooms. The construct of learning approaches is presented as one of the factors that influences the school performance of students. Besides, an outlook of the empirical research works related to variables that are presented as relevant when explaining the reason for a specific performance in students is shown. Finally, some models and techniques allowing an appropriate study of school performance are presented.

  10. Selected plantar pressure characteristics associated with the skating performance of national in-line speed skaters.

    Science.gov (United States)

    Wu, Wen-Lan; Hsu, Hsiu-Tao; Chu, I-Hua; Tsai, Feng-Hua; Liang, Jing-Min

    2017-06-01

    In order to help coaches analyse the techniques of professional in-line speed skaters for making the required fine adjustments and corrections in their push-off work, this study analysed the specific plantar pressure characteristics during a 300-m time-trial test. Fourteen elite in-line speed skaters from the national team were recruited in this study. The total completion time of the 300-m time-trial test, duration of each skating phase, and plantar pressure distribution were measured. The correlation between plantar pressure distribution and skating performance was assessed using Pearson correlation analyses. The results showed that the contact time of the total foot and force-time integral (FTI) in the medial forefoot were significantly correlated with the duration of the start phase, and the FTIs in the medial forefoot of the gliding (left) leg and lateral forefoot of the pushing (right) leg were significantly correlated with the duration of the turning phase. The maximum force in the medial heel, medial forefoot, and median forefoot and the FTI in the medial heel and medial forefoot were significantly correlated with the duration of the linear acceleration phase. The results suggest that a correct plantar loading area and push-off strategy can enhance the skating performance.

  11. Performance managenemt

    DEFF Research Database (Denmark)

    Jacobi, Claus Brygger

    This paper attempts to identify barriers that prevent performance management from being genuinely result-based. By observing what happened when a Danish workfare reform was implemented by applying performance management, it becomes apparent that there exists internal decouplings on and between two...... levels; a decoupling between the monitoring/evaluation of established performance indicators and the revising of these for policy-making on future interventions, and a decoupling between the strategic political/administrative level and operational street-level, inhibiting its adaption to local...

  12. International society of sports nutrition position stand: caffeine and performance

    Directory of Open Access Journals (Sweden)

    Wildman Robert

    2010-01-01

    Full Text Available Abstract Position Statement: The position of The Society regarding caffeine supplementation and sport performance is summarized by the following seven points: 1. Caffeine is effective for enhancing sport performance in trained athletes when consumed in low-to-moderate dosages (~3-6 mg/kg and overall does not result in further enhancement in performance when consumed in higher dosages (≥ 9 mg/kg. 2. Caffeine exerts a greater ergogenic effect when consumed in an anhydrous state as compared to coffee. 3. It has been shown that caffeine can enhance vigilance during bouts of extended exhaustive exercise, as well as periods of sustained sleep deprivation. 4. Caffeine is ergogenic for sustained maximal endurance exercise, and has been shown to be highly effective for time-trial performance. 5. Caffeine supplementation is beneficial for high-intensity exercise, including team sports such as soccer and rugby, both of which are categorized by intermittent activity within a period of prolonged duration. 6. The literature is equivocal when considering the effects of caffeine supplementation on strength-power performance, and additional research in this area is warranted. 7. The scientific literature does not support caffeine-induced diuresis during exercise, or any harmful change in fluid balance that would negatively affect performance.

  13. Performative Environments

    DEFF Research Database (Denmark)

    Thomsen, Bo Stjerne

    2008-01-01

    The paper explores how performative architecture can act as a collective environment localizing urban flows and establishing public domains through the integration of pervasive computing and animation techniques. The NoRA project introduces the concept of ‘performative environments,' focusing on ...... of local interactions and network behaviour, building becomes social infrastructure and prompts an understanding of architectural structures as quasiobjects, which can retain both variation and recognisability in changing social constellations.......The paper explores how performative architecture can act as a collective environment localizing urban flows and establishing public domains through the integration of pervasive computing and animation techniques. The NoRA project introduces the concept of ‘performative environments,' focusing...

  14. Performance assessment

    International Nuclear Information System (INIS)

    Doe, T.

    1985-01-01

    The purpose of performance assessment is to show that the repository is expected to serve its stated function - disposing of radioactive waste safely both during operation and for the postclosure period. Performance assessment is a straightforward concept, but its application may be very complicated. The concept of performance assessment has been clarified by the Nuclear Regulatory Commission (NRC) in their Draft Generic Technical Position on Licensing Assessment Methodology for High-Level Waste Geologic Repositories (NRC, 1984). This document has gone a long way toward defining the criteria that the NRC will use to determine whether or not information from site characterization is adequate to meet the regulations of the Nuclear Regulatory Commission and the Environmental Protection Agency (EPA). A favorable determination is required for issuance of a construction authorization, which is the first major regulatory requirement for developing a working repository. It is, therefore, essential that a research program be developed that not only resolves the outstanding technical issues, but also does it in such a way that the results are clearly applicable to the formal performance assessment and licensing procedures. The definitions of performance assessment are reviewed and the current NRC thinking is summarized

  15. Energy system contributions and determinants of performance in sprint cross-country skiing

    DEFF Research Database (Denmark)

    Andersson, E; Björklund, G; Holmberg, H-C

    2017-01-01

    To improve current understanding of energy contributions and determinants of sprint-skiing performance, 11 well-trained male cross-country skiers were tested in the laboratory for VO2max , submaximal gross efficiency (GE), maximal roller skiing velocity, and sprint time-trial (STT) performance...... during the STT was predicted from the submaximal relationships for GE against velocity and incline, allowing computation of metabolic rate and O2 deficit. The skiers completed the STT in 232 ± 10 s (distributed as 55 ± 3% DP and 45 ± 3% DS) with a mean power output of 324 ± 26 W. The anaerobic energy......-skiing has demonstrated an anaerobic energy contribution of 18%, with GE being the strongest predictor of performance....

  16. Performative Silences

    DEFF Research Database (Denmark)

    Dupret, Katia

    2018-01-01

    static nor neutral. It has performative effects. Silencing as an act, rather than a noun, is conceptualised as a central ‘configurating actor’ of change. Through the description of minute details from a videotaped supervision session in the mental healthcare sector, it is shown how different performative...... configurations of silence makes people relate to each other in new ways and influence new work practices. In spite of its somewhat immaterial connotations, using an Actor-Network Theory approach to organization studies, silencing is conceptualised as both a means and an effect of change efforts, which are socio...

  17. Brain mapping after prolonged cycling and during recovery in the heat.

    Science.gov (United States)

    De Pauw, Kevin; Roelands, Bart; Marusic, Uros; Tellez, Helio Fernandez; Knaepen, Kristel; Meeusen, Romain

    2013-11-01

    The aim of this study was to determine the effect of prolonged intensive cycling and postexercise recovery in the heat on brain sources of altered brain oscillations. After a max test and familiarization trial, nine trained male subjects (23 ± 3 yr; maximal oxygen uptake = 62.1 ± 5.3 ml·min(-1)·kg(-1)) performed three experimental trials in the heat (30°C; relative humidity 43.7 ± 5.6%). Each trial consisted of two exercise tasks separated by 1 h. The first was a 60-min constant-load trial, followed by a 30-min simulated time trial (TT1). The second comprised a 12-min simulated time trial (TT2). After TT1, active recovery (AR), passive rest (PR), or cold water immersion (CWI) was applied for 15 min. Electroencephalography was measured at baseline and during postexercise recovery. Standardized low-resolution brain electromagnetic tomography was applied to accurately pinpoint and localize altered electrical neuronal activity. After CWI, PR and AR subjects completed TT2 in 761 ± 42, 791 ± 76, and 794 ± 62 s, respectively. A prolonged intensive cycling performance in the heat decreased β activity across the whole brain. Postexercise AR and PR elicited no significant electrocortical differences, whereas CWI induced significantly increased β3 activity in Brodmann areas (BA) 13 (posterior margin of insular cortex) and BA 40 (supramarginal gyrus). Self-paced prolonged exercise in the heat seems to decrease β activity, hence representing decreased arousal. Postexercise CWI increased β3 activity at BA 13 and 40, brain areas involved in somatosensory information processing.

  18. Evidence for spin correlation in ttˉ production

    Czech Academy of Sciences Publication Activity Database

    Abazov, V. M.; Abbott, B.; Acharya, B.S.; Kupčo, Alexander; Lokajíček, Miloš

    2012-01-01

    Roč. 108, č. 3 (2012), "032004-1"-"032004-7" ISSN 0031-9007 R&D Projects: GA MŠk LA08047 Institutional research plan: CEZ:AV0Z10100502 Keywords : Batavia TEVATRON Coll * correlation dilepton * pair production * final state * D0 * anti-p p interaction Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 7.943, year: 2012 http://prl.aps.org/abstract/PRL/v108/i3/e032004

  19. Small phosphatidate phosphatase (TtPAH2) of Tetrahymena ...

    Indian Academy of Sciences (India)

    Anoop Narayana Pillai

    2017-10-03

    Oct 3, 2017 ... There was no significant difference (indicated as 'ns') in the number of lipid droplets as analysed by Kruskal-Wallis test. (p \\0.01). .... and Goodman JM 2011 The yeast lipin orthologue Pah1p is ... gamma transcriptional activity.

  20. Oma kool - parim kool! / Maris Kütt, Mirli Isak

    Index Scriptorium Estoniae

    Kütt, Maris

    2012-01-01

    Võru 1. Põhikool tähistab 220 aastapäeva. Artiklisse on kogutud praeguste õpilaste vastused küsimusele, mida nad arvavad oma auväärsesse ikka jõudnud koolist. Ka TLÜ rektori Tiit Landi meenutused oma kooliajast

  1. Haapsalus tutvustatakse innovatiivseid lahendusi / Madiken Kütt

    Index Scriptorium Estoniae

    Kütt, Madiken

    2011-01-01

    Haapsalus toimuvast rahvusvahelisest innovatsiooniteemalisest seminarist Innovation SEEDS, kus tuleb juttu innovatsioonist ettevõtluses ja haridusvaldkonnas. Üritust korraldab TLÜ Haapsalu kolledž. Konverents peetakse rahvusvahelise projekti "Central Baltic innovation tools for practice" raames. Seminari peaesineja on Tallinna Ülikooli terviseteaduste ja spordi instituudi direktor Kristjan Port

  2. Performing Brexit

    DEFF Research Database (Denmark)

    Adler-Nissen, Rebecca; Galpin, Charlotte; Rosamond, Ben

    2017-01-01

    constructed from the outside. Brexit signifies more than the technical complexities of the UK withdrawing from the European Union. It works both as a promise of a different future and performatively to establish a particular past. Brexit works as a frame with potential to shape perceptions in three domains...

  3. Performance Design

    DEFF Research Database (Denmark)

    Svabo, Connie

    Contribution to conference: Art and Presence The emerging field of Performance Design is unfolded as a bastard form of research/art/design/practice, with shapeshifting, monstruous, hybrid and transformational qualities. The potential for presencing, which emerges out of momentarily transgressing...

  4. A New Nordic Balance: Nordic security policies and their impact on Iceland Nýtt norrænt jafnvægi. Öryggisstefnur Norðurlandanna og áhrif þeirra á Ísland

    Directory of Open Access Journals (Sweden)

    Silja Bára Ómarsdóttir

    2010-12-01

    Full Text Available Iceland‘s security policy is under review in the wake of the departure of the US military. While policy making is still under way, one of the options frequently mentioned is that of an increased cooperation with the Nordic countries. The article thus reviews the Nordic countries‘ security policies, especially in light of the recent revision of the EU‘s Lisbon Treaty, creating a Solidarity Clause. The article employs the Securitization theory presented by Ole Wæver and the Copenhagen School in international relations toshed a lighton the Nordic countries‘ different approaches to security. The security and defence policies of the four Nordic countries are analyzed, but for Iceland speeches of the Minister for Foreign Affairs are used, as no formal security policy exists. The article concludes that the Nordic countries are likely to continue their cooperation with NATO and the EU, although Norway, Sweden and Finland may, in particular, benefit from increased Nordic cooperation. Iceland‘s security interests are not likely to be served by increased Nordic cooperation, such as that proposed by the Stoltenberg Report, as it would be more symbolic than practical.Öryggismál Íslands eru í endurskoðun í kjölfar brottfarar Bandaríkjahers frá landinu. Þótt stefnumótun sé enn ólokið hefur m.a. verið litið til aukins samstarfs við önnur ríki Norðurlanda. Í greininni er farið yfir öryggisstefnur Norðurlandanna í ljósi nýlegra breytinga á Lissabon-sáttmála Evrópusambandsins þar sem samstöðuákvæði er sett inn í sáttmálann. Skoðað er hvaða áhrif þessar breytingar gætu haft á Ísland og stöðu þess. Öryggisvæðingarkenningar Ole Wævers og Kaupmannahafnarskólans í alþjóðasamskiptum eru notaðar til að varpa ljósi á ólíkar nálganir Norðurlandanna í varnarmálum. Leitað er fanga í öryggis- og varnarmálastefnum Norðurlandanna fjögurra en í ræðum utanríkisráðherra á Íslandi,

  5. Site preference of metal atoms in Gd_5_-_xM_xTt_4 (M = Zr, Hf; Tt = Si, Ge)

    International Nuclear Information System (INIS)

    Yao, Jinlei; Mozharivskyj, Yurij

    2011-01-01

    Zirconium and hafnium were incorporated into the Gd_5Ge_4 and Gd_5Si_4 parent compounds in order to study the metal-site occupation in the M_5X_4 magnetocaloric phases (M = metals; X = p elements) family. The Gd_5_-_xZr_xGe_4 phases adopt the orthorhombic Sm_5Ge_4-type (space group Pnma) structure for x ≤ 1.49 and the tetragonal Zr_5Si_4-type (P4_12_12) structure for x ≥ 1.77. The Gd_5_-_xHf_xSi_4 compounds crystallize in the orthorhombic Gd_5Si_4-type (Pnma) structure for x ≤ 0.41 and the Zr_5Si_4-type structure for x ≥ 0.7. In both systems, single-crystal X-ray diffraction reveals that the Zr/Hf atoms preferentially occupy the slab-surface M2 and slab-center M3 sites, both of which have a significantly larger Zr/Hf population than the slab-surface M1 site. The metal-site preference, i.e. the coloring problem on the three metal sites, is discussed considering geometric and electronic effects of the local coordination environments. The analysis of the metal-site occupation in Gd_5_-_xZr_xGe_4 and Gd_5_-_xHf_xSi_4 as well as other metal-substituted M_5X_4 systems suggests that both geometric and electronic effects can be used to explain the metal-site occupation. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  6. Urban performances

    DEFF Research Database (Denmark)

    Samson, Kristine

    2012-01-01

    Through three different urban performances, the paper investigates how, when and under which circumstances urban space is transformed and distorted from its every day use and power relations. Distortion is an annual street festival in Copenhagen with the objective to distort the functional city...... creates an intensive space for the empowerment and liberation of the body. Occupy Wall street and its action in the autumn 2001 is the ultimate example of how urban political performances intensifies and transform every day spaces. Through examples of how OWS tactically appropriates and transforms urban...... space, I seek to show how representational space, for instance the public square, is transformed and distorted by heterogeneous and unforeseen modes of operating. Despite differing in their goal and outset, I wish to unfold an alternative to urban transformation practices in planning and architecture...

  7. Performative securitization

    DEFF Research Database (Denmark)

    Philipsen, Lise

    2018-01-01

    This piece develops a performative take on securitization theory. It argues that rather than seeing authority as a prerequisite for speaking security, we need to zoom in on how speaking security can be used to claim authority. Such acts of claiming authority are crucial to understand the current...... challenged and changed. Two, following Butler, we must open up who can speak security, seeing how speaking security can be used to take authority, rather than seeing authority as a precondition for speaking security....

  8. The effect of the MTHFR C677T mutation on athletic performance and the homocysteine level of soccer players and sedentary individuals

    Directory of Open Access Journals (Sweden)

    Dinç Nurten

    2016-06-01

    Full Text Available This study investigated athletic performance and homocysteine (Hcy levels in relation to the methylenetetrahydrofolate reductase (MTHFR C677T mutation and explored the relationship between this mutation and other cardiac risk factors in soccer players and sedentary individuals. The study groups consisted of randomly selected soccer players (n=48 from the Turkish Super and Major League and sedentary male students (n=48 aged 18-27. Anthropometric variables, aerobic and anaerobic thresholds were measured, furthermore, biochemical assays were performed. The level of HDL cholesterol, LDL cholesterol, triglyceride, Hcy, folate, vitamin B12, hemogram and MTHFR C677T was investigated. The results showed that there was a statistical difference between the two groups in terms of body mass, body fat, the BMI, the aerobic threshold heart rate (ATHR, aerobic threshold velocity (ATVL and anaerobic threshold velocity (ANTVL. The soccer players were found to have lower levels of triglyceride, total cholesterol and LDL cholesterol, and higher levels of folate than the sedentary participants. The analysis of the alleles of the MTHFR C677T polymorphism showed that the participants that carried TT genotypes had a lower level of vitamin B12 and folate, and a higher level of Hcy than the participants carrying CC and CT genotypes. In conclusion, the baseline homocysteine and cardiovascular fitness levels of healthy young males with the TT genotypes of the MTHFR C677T genotype were found to strongly correlate with their levels of Hcy.

  9. Periodization of Carbohydrate Intake: Short-Term Effect on Performance

    Directory of Open Access Journals (Sweden)

    Laurie-Anne Marquet

    2016-11-01

    Full Text Available Background: “Sleep-low” consists of a sequential periodization of carbohydrate (CHO availability—low glycogen recovery after “train high” glycogen-depleting interval training, followed by an overnight-fast and light intensity training (“train low” the following day. This strategy leads to an upregulation of several exercise-responsive signaling proteins, but the chronic effect on performance has received less attention. We investigated the effects of short-term exposure to this strategy on endurance performance. Methods: Following training familiarization, 11 trained cyclists were divided into two groups for a one-week intervention—one group implemented three cycles of periodized CHO intake to achieve the sleep-low strategy over six training sessions (SL, CHO intake: 6 g·kg−1·day−1, whereas the control group consumed an even distribution of CHO over the day (CON. Tests were a 2 h submaximal ride and a 20 km time trial. Results: SL improved their performance (mean: +3.2%; p < 0.05 compared to CON. The improvement was associated with a change in pacing strategy with higher power output during the second part of the test. No change in substrate utilization was observed after the training period for either group. Conclusion: Implementing the “sleep-low” strategy for one week improved performance by the same magnitude previously seen in a three-week intervention, without any significant changes in selected markers of metabolism.

  10. Periodization of Carbohydrate Intake: Short-Term Effect on Performance

    Science.gov (United States)

    Marquet, Laurie-Anne; Hausswirth, Christophe; Molle, Odeline; Hawley, John A.; Burke, Louise M.; Tiollier, Eve; Brisswalter, Jeanick

    2016-01-01

    Background: “Sleep-low” consists of a sequential periodization of carbohydrate (CHO) availability—low glycogen recovery after “train high” glycogen-depleting interval training, followed by an overnight-fast and light intensity training (“train low”) the following day. This strategy leads to an upregulation of several exercise-responsive signaling proteins, but the chronic effect on performance has received less attention. We investigated the effects of short-term exposure to this strategy on endurance performance. Methods: Following training familiarization, 11 trained cyclists were divided into two groups for a one-week intervention—one group implemented three cycles of periodized CHO intake to achieve the sleep-low strategy over six training sessions (SL, CHO intake: 6 g·kg−1·day−1), whereas the control group consumed an even distribution of CHO over the day (CON). Tests were a 2 h submaximal ride and a 20 km time trial. Results: SL improved their performance (mean: +3.2%; p < 0.05) compared to CON. The improvement was associated with a change in pacing strategy with higher power output during the second part of the test. No change in substrate utilization was observed after the training period for either group. Conclusion: Implementing the “sleep-low” strategy for one week improved performance by the same magnitude previously seen in a three-week intervention, without any significant changes in selected markers of metabolism. PMID:27897989

  11. Effects of dietary antioxidants on training and performance in female runners.

    Science.gov (United States)

    Braakhuis, Andrea J; Hopkins, Will G; Lowe, Tim E

    2014-01-01

    Exercise-induced oxidative stress is implicated in muscle damage and fatigue which has led athletes to embark on antioxidant supplementation regimes to negate these effects. This study investigated the intake of vitamin C (VC) (1 g), blackcurrant (BC) juice (15 mg VC, 300 mg anthocyanins) and placebo in isocaloric drink form on training progression, incremental running test and 5-km time-trial performance. Twenty-three trained female runners (age, 31 ± 8 y; mean ± SD) completed three blocks of high-intensity training for 3 wks and 3 days, separated by a washout (~3.7 wks). Changes in training and performance with each treatment were analysed with a mixed linear model, adjusting for performance at the beginning of each training block. Markers of oxidative status included protein carbonyl, malondialdehyde (in plasma and in vitro erythrocytes), ascorbic acid, uric acid and erythrocyte enzyme activity of superoxide dismutase, catalase and glutathione peroxidase were analysed. There was a likely harmful effect on mean running speed during training when taking VC (1.3%; 90% confidence limits ±1.3%). Effects of the two treatments relative to placebo on mean performance in the incremental test and time trial were unclear, but runners faster by 1 SD of peak speed demonstrated a possible improvement on peak running speed with BC juice (1.9%; ±2.5%). Following VC, certain oxidative markers were elevated: catalase at rest (23%; ±21%), protein carbonyls at rest (27%; ±38%) and superoxide dismutase post-exercise (8.3%; ±9.3%). In conclusion, athletes should be cautioned about taking VC chronically, however, BC may improve performance in the elite.

  12. Cycling in the Absence of Task-related Feedback: Effects on Pacing and Performance

    Directory of Open Access Journals (Sweden)

    Benjamin Smits

    2016-08-01

    Full Text Available Introduction. To achieve personal goals in exercise task completion, exercisers have to regulate, distribute and manage their effort. In endurance sports, it has become very commonplace for athletes to consult task-related feedback on external devices to do so. The aim of the present study was to explore the importance of the presence of this information by examining the influence of the absence of commonly available task-related feedback on effort distribution and performance in experienced endurance athletes.Methods. A 20-km cycling time trial was performed. 20 Participants from a homogenous cyclist population were appointed to a group that did not receive any feedback (NoF, or a group that could consult task-related feedback (i.e., speed, heart rate, power output, cadence, elapsed time and elapsed distance continuously during their trial (FF.Results. The distribution of power output (PO differed between groups. Most evident is the spurt at the end of the trial of FF, which was not incorporated by NoF. Nevertheless, no between-group differences were found in performance time (FF: 28.86 +/- 3.68 min vs. NoF: 30.95 +/- 2.77 min and mean PO controlled by body mass (FF: 3.61 +/- .60 W/kg vs. NoF: 3.43 +/- .38 W/kg. Also, no differences in rating of perceived exertion scores were found.Conclusion. The current study provides a first indication that prior knowledge of task demands together with reliance on bodily and environmental information can be sufficient for experienced athletes to come to comparable time trial performances. This questions the necessity of the presence of in-race instantaneous task-related feedback via external devices for maximising performance. Moreover, it seems that different pacing strategies emerge depending on sources of information available to experienced athletes.

  13. ORELA performance

    International Nuclear Information System (INIS)

    Lewis, T.A.

    1976-04-01

    The most recent information concerning the performance of ORELA that would be of interest to experimenters is presented. Included are characteristics of the beam in terms of both time and intensity and descriptions of systems routinely used to monitor these beam characteristics. For example, with klystron power and maximum electron gun output current at nominal values and for pulse repetition rates in the range above 800 pps, output beam energies per pulse vary from 5 J for 2.5 nsec-wide pulses to approximately 32 J for 10 nsec pulses and 65 J for 40 nsec pulses

  14. Application of the coupled code Athlet-Quabox/Cubbox for the extreme scenarios of the OECD/NRC BWR turbine trip benchmark and its performance on multi-processor computers

    International Nuclear Information System (INIS)

    Langenbuch, S.; Schmidt, K.D.; Velkov, K.

    2003-01-01

    The OECD/NRC BWR Turbine Trip (TT) Benchmark is investigated to perform code-to-code comparison of coupled codes including a comparison to measured data which are available from turbine trip experiments at Peach Bottom 2. This Benchmark problem for a BWR over-pressure transient represents a challenging application of coupled codes which integrate 3-dimensional neutron kinetics into thermal-hydraulic system codes for best-estimate simulation of plant transients. This transient represents a typical application of coupled codes which are usually performed on powerful workstations using a single CPU. Nowadays, the availability of multi-CPUs is much easier. Indeed, powerful workstations already provide 4 to 8 CPU, computer centers give access to multi-processor systems with numbers of CPUs in the order of 16 up to several 100. Therefore, the performance of the coupled code Athlet-Quabox/Cubbox on multi-processor systems is studied. Different cases of application lead to changing requirements of the code efficiency, because the amount of computer time spent in different parts of the code is varying. This paper presents main results of the coupled code Athlet-Quabox/Cubbox for the extreme scenarios of the BWR TT Benchmark together with evaluations of the code performance on multi-processor computers. (authors)

  15. Performance of

    Directory of Open Access Journals (Sweden)

    Naema A. Ali

    2015-09-01

    Full Text Available Soil collapse occurs when increased moisture causes chemical or physical bonds between the soil particles to weaken, which allows the structure of the soil to collapse. Collapsible soils are generally low-density, fine-grained combinations of clay and sand left by mudflows that have dried, leaving tiny air pockets. When the soil is dry, the cemented materials are strong enough to bond the sand particles together. When natural soil becomes wet, moisture alters the cementation structure and the soil’s strength is compromised, causing collapse or subsidence. Based on soil type and density, the potential for encountering collapsible soils throughout most of the project alignment is low. Conditions in arid and semi-arid climates like Borg El Arab, near Alexandria Egypt favor the formation of the most problematic collapsible soils. The behavior and performance of compacted sand replacement over treated collapsible soil by pre-wetting and compaction are investigated in the current study. Field investigation was performed in the form of plate loading tests conducted on compacted sand replacement over improved collapsible soil. Field plate load tests program was developed to explore the effect of compacted sand replacement thickness on collapsibility potential. Treated collapsible soil was replaced with imported cohesionless soil with variable thickness up to footing width. Results proved that the improvement of collapsible soils by sand/crushed stone replacement is possible to control/mitigate their risk potentials against sudden settlement when exposed to water. Replacement soil increases the rate and reduces the amount of footing settlement. For compacted collapsible soils, partial replacement by compacted sand/crushed stone layers decreases collapsibility potential risk. Results also, introduce the development of practical, economical and environmentally safe geochemical methods for collapsible soil stabilization and collapsible risk mitigation.

  16. HIIT enhances endurance performance and aerobic characteristics more than high-volume training in trained rowers.

    Science.gov (United States)

    Ní Chéilleachair, Niamh J; Harrison, Andrew J; Warrington, Giles D

    2017-06-01

    This study compared the effects of long slow distance training (LSD) with high-intensity interval training (HIIT) in rowers. Nineteen well-trained rowers performed three tests before and after an 8-week training intervention: (1) 2000 m time trial; (2) seven-stage incremental step test to determine maximum oxygen uptake ([Formula: see text]O 2max ), power output at [Formula: see text]O 2max (W[Formula: see text]O 2max ), peak power output (PPO), rowing economy and blood lactate indices and (3) seven-stroke power-output test to determine maximal power output (W max ) and force (F max ). After baseline testing, participants were randomly assigned either to a HIIT or LSD group. The LSD comprised 10 weekly aerobic sessions. The HIIT also comprised 10 weekly sessions: 8 aerobic and 2 HIIT. The HIIT sessions comprised 6-8 × 2.5 min intervals at 100% PPO with recovery time based on heart rate (HR) returning to 70% HR max . Results demonstrated that the HIIT produced greater improvement in 2000 m time trial performance than the LSD (effect size (ES) = 0.25). Moreover, the HIIT produced greater improvements in [Formula: see text]O 2max (ES = 0.95, P = 0.035) and power output at lactate threshold (W LT ) (ES = 1.15, P = 0.008). Eight weeks of HIIT performed at 100% PPO is more effective than LSD in improving performance and aerobic characteristics in well-trained rowers.

  17. Effect of contrast water therapy duration on recovery of running performance.

    Science.gov (United States)

    Versey, Nathan G; Halson, Shona L; Dawson, Brian T

    2012-06-01

    To investigate whether contrast water therapy (CWT) assists acute recovery from high-intensity running and whether a dose-response relationship exists. Ten trained male runners completed 4 trials, each commencing with a 3000-m time trial, followed by 8 × 400-m intervals with 1 min of recovery. Ten minutes postexercise, participants performed 1 of 4 recovery protocols: CWT, by alternating 1 min hot (38°C) and 1 min cold (15°C) for 6 (CWT6), 12 (CWT12), or 18 min (CWT18), or a seated rest control trial. The 3000-m time trial was repeated 2 h later. 3000-m performance slowed from 632 ± 4 to 647 ± 4 s in control, 631 ± 4 to 642 ± 4 s in CWT6, 633 ± 4 to 648 ± 4 s in CWT12, and 631 ± 4 to 647 ± 4 s in CWT18. Following CWT6, performance (smallest worthwhile change of 0.3%) was substantially faster than control (87% probability, 0.8 ± 0.8% mean ± 90% confidence limit), however, there was no effect for CWT12 (34%, 0.0 ± 1.0%) or CWT18 (34%, -0.1 ± 0.8%). There were no substantial differences between conditions in exercise heart rates, or postexercise calf and thigh girths. Algometer thigh pain threshold during CWT12 was higher at all time points compared with control. Subjective measures of thermal sensation and muscle soreness were lower in all CWT conditions at some post-water-immersion time points compared with control; however, there were no consistent differences in whole body fatigue following CWT. Contrast water therapy for 6 min assisted acute recovery from high-intensity running; however, CWT duration did not have a dose-response effect on recovery of running performance.

  18. Can psychological well-being scales and hormone levels be used to predict acute performance of anaerobic training tasks in elite female volleyball players?

    Science.gov (United States)

    Mielgo-Ayuso, Juan; Zourdos, Michael C; Clemente-Suárez, Vicente J; Calleja-González, Julio; Shipherd, Amber M

    2017-10-15

    The purpose of this study was to examine relationships between pre-training psychological well-being assessment scales (General Health Questionnaire-28-GHQ-28, Competitive State Anxiety Inventory-2-CSAI-2, Sport Competition Anxiety Test-SCAT, State-Trait Anxiety Inventory-S-STAI-S, Oviedo Sleep Questionnaire-OSQ and Psychological Characteristics Related to Sport Performance-PCSP), and pre-training stress hormone concentrations (cortisol-C, total testosterone-TT, free testosterone-FT, adrenocorticotropic hormone-ACTH and testosterone/cortisol-T/C ratios), on acute neuromuscular performance (ANP) in female volleyballers. Forty elite female volleyballers (27±4yrs.; 178.3±8.5cm; 67.9±7.2kg) participated. Bivariate correlations were performed between psychological assessments and hormone levels with ANP. All psychological scales presented at least one significant (pvolleyballers than pre-training stress hormone concentrations. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Effects of shoe cleat position on physiology and performance of competitive cyclists.

    Science.gov (United States)

    Paton, Carl D

    2009-12-01

    Aerobic economy is an important factor that affects the performance of competitive cyclists. It has been suggested that placing the foot more anteriorly on the bicycle pedals may improve economy over the traditional foot position by improving pedaling efficiency. The current study examines the effects of changing the anterior-posterior pedal foot position on the physiology and performance of well-trained cyclists. In a crossover study, 10 competitive cyclists completed two maximal incremental and two submaximal tests in either their preferred (control) or a forward (arch) foot position. Maximum oxygen consumption and peak power output were determined from the incremental tests for both foot positions. On two further occasions, cyclists also completed a two-part 60-min submaximal test that required them to maintain a constant power output (equivalent to 60% of their incremental peak power) for 30 min, during which respiratory and blood lactate samples were taken at predetermined intervals. Thereafter, subjects completed a 30-min self-paced maximal effort time trial. Relative to the control, the mean changes (+/-90% confidence limits) in the arch condition were as follows: maximum oxygen consumption, -0.5% (+/-2.0%); incremental peak power output, -0.8% (+/-1.3%); steady-state oxygen consumption at 60%, -2.4% (+/-1.1%); steady-state heart rate 60%, 0.4% (+/-1.7%); lactate concentration 60%, 8.7% (+/-14.4%); and mean time trial power, -1.5% (+/-2.9%). We conclude that there was no substantial physiological or performance advantage in this group using an arch-cleat shoe position in comparison with a cyclist's normal preferred condition.

  20. Performance and carcass characteristics of steers fed with two levels of metabolizable energy intake during summer and winter season.

    Science.gov (United States)

    Arias, R A; Keim, J P; Gandarillas, M; Velásquez, A; Alvarado-Gilis, C; Mader, T L

    2018-05-22

    Climate change is producing an increase on extreme weather events around the world such as flooding, drought and extreme ambient temperatures impacting animal production and animal welfare. At present, there is a lack of studies addressing the effects of climatic conditions associated with energy intake in finishing cattle in South American feed yards. Therefore, two experiments were conducted to assess the effects of environmental variables and level of metabolizable energy intake above maintenance requirements (MEI) on performance and carcass quality of steers. In each experiment (winter and summer), steers were fed with 1.85 or 2.72 times of their requirements of metabolizable energy of maintenance. A total of 24 crossbred steers per experiment were used and located in four pens (26.25 m2/head) equipped with a Calan Broadbent Feeding System. Animals were fed with the same diet within each season, varying the amount offered to adjust the MEI treatments. Mud depth, mud scores, tympanic temperature (TT), environmental variables, average daily gain, respiration rates and carcass characteristics plus three thermal comfort indices were collected. Data analysis considered a factorial arrangement (Season and MEI). In addition, a repeated measures analysis was performed for TT and respiration rate. Mean values of ambient temperature, solar radiation and comfort thermal indices were greater in the summer experiment as expected (Pcarcass characteristics were affected by season but not by the level of MEI. Finally, due to the high variability of data as well as the small number of animals assessed in these experiments, more studies on carcass characteristics under similar conditions are required.

  1. Performance Management or Performance Based Management?

    OpenAIRE

    Cristina PROTOPOPESCU

    2013-01-01

    In this paper we present some considerations about performance and performance management. Starting with the challenge of defining the performance concept, we intend to establish if „performance management” can be a new management system or it is just a sophisticated term for a HR strategy in order to improve the performance of teams and individuals. We also try to discuss the conection between performance management and management by objectives. Whether or not it is exageratted to talk about...

  2. Effect of sodium bicarbonate supplementation on 2000-m rowing performance.

    Science.gov (United States)

    Hobson, Ruth M; Harris, Roger C; Martin, Dan; Smith, Perry; Macklin, Ben; Elliott-Sale, Kirsty J; Sale, Craig

    2014-01-01

    The ability to buffer H+ could be vital to exercise performance, as high concentrations of H+ contribute to the development of fatigue. The authors examined the effect of sodium bicarbonate (SB) supplementation on 2000-m rowing-ergometer performance. Twenty male rowers (age 23 ± 4 y, height 1.85 ± 0.08 m, mass 82.5 ± 8.9 kg, 2000-m personal-best time 409 ± 16 s) completed two 2000-m rowing-ergometer time trials, separated by 48 h. Participants were supplemented before exercise with 0.3 g/kg body mass of SB or a placebo (maltodextrin; PLA). The trials were conducted using a double-blinded, randomized, counterbalanced crossover study design. Time to complete the 2000-m and time taken for each 500-m split were recorded. Blood lactate, bicarbonate, pH, and base excess were determined preexercise, immediately postexercise, and 5 min postexercise. Performance data were analyzed using paired t tests, as well as magnitude-based inferences; hematological data were analyzed using a repeated-measures ANOVA. Using paired t tests, there was no benefit of SB over PLA (P = .095). However, using magnitude-based inferences there was a likely beneficial effect of SB compared with PLA (PLA 412.0 ± 15.1 s, SB 410.7 ± 14.9 s). Furthermore, SB was 0.5 ± 1.2 s faster than PLA in the third 500 m (P = .035; possibly beneficial) and 1.1 ± 1.7 s faster in the fourth 500 m (P = .004; very likely beneficial). All hematological data were different between SB and PLA and were different from preexercise to postexercise. SB supplementation is likely to be beneficial to the performance of those competing in 2000-m rowing events, particularly in the second half of the event.

  3. Is carbohydrate mouth rinsing a novel approach to maintain exercise performance during Ramadan fasting?

    Directory of Open Access Journals (Sweden)

    Ahmad Munir Che Muhamed

    2014-12-01

    Full Text Available About a decade ago, carbohydrate mouth rinsing was shown to enhance endurance exercise performance. This improvement was more pronounced in a fasted compared to a fed state, suggesting that the ergogenic effect of carbohydrate mouth rinse is dependent on endogenous carbohydrate storage. Hence, indirectly highlights the potential use of carbohydrate mouth rinse as a potential strategy to mitigate the adverse effects of exercise during Ramadan fasting. To date, only one study has been carried out to explore the potential benefit of carbohydrate mouth rinse on exercise performance during Ramadan fasting. This single observation showed that a 10-km time trial performance was enhanced when performing mouth rinsing with either a carbohydrate or a placebo solution as compared with not performing mouth rinsing. While one study had acknowledged that the practice of mouth rinsing do have a positive effect on exercise performance during Ramadan fasting, future studies is warranted in order to have a better understanding on the underlying mechanisms associated with carbohydrate mouth rinsing during Ramadan fasting.

  4. Understanding protocol performance: impact of test performance.

    Science.gov (United States)

    Turner, Robert G

    2013-01-01

    This is the second of two articles that examine the factors that determine protocol performance. The objective of these articles is to provide a general understanding of protocol performance that can be used to estimate performance, establish limits on performance, decide if a protocol is justified, and ultimately select a protocol. The first article was concerned with protocol criterion and test correlation. It demonstrated the advantages and disadvantages of different criterion when all tests had the same performance. It also examined the impact of increasing test correlation on protocol performance and the characteristics of the different criteria. To examine the impact on protocol performance when individual tests in a protocol have different performance. This is evaluated for different criteria and test correlations. The results of the two articles are combined and summarized. A mathematical model is used to calculate protocol performance for different protocol criteria and test correlations when there are small to large variations in the performance of individual tests in the protocol. The performance of the individual tests that make up a protocol has a significant impact on the performance of the protocol. As expected, the better the performance of the individual tests, the better the performance of the protocol. Many of the characteristics of the different criteria are relatively independent of the variation in the performance of the individual tests. However, increasing test variation degrades some criteria advantages and causes a new disadvantage to appear. This negative impact increases as test variation increases and as more tests are added to the protocol. Best protocol performance is obtained when individual tests are uncorrelated and have the same performance. In general, the greater the variation in the performance of tests in the protocol, the more detrimental this variation is to protocol performance. Since this negative impact is increased as

  5. Textiles Performance Testing Facilities

    Data.gov (United States)

    Federal Laboratory Consortium — The Textiles Performance Testing Facilities has the capabilities to perform all physical wet and dry performance testing, and visual and instrumental color analysis...

  6. Caffeine withdrawal and high-intensity endurance cycling performance.

    Science.gov (United States)

    Irwin, Christopher; Desbrow, Ben; Ellis, Aleisha; O'Keeffe, Brooke; Grant, Gary; Leveritt, Michael

    2011-03-01

    In this study, we investigated the impact of a controlled 4-day caffeine withdrawal period on the effect of an acute caffeine dose on endurance exercise performance. Twelve well-trained and familiarized male cyclists, who were caffeine consumers (from coffee and a range of other sources), were recruited for the study. A double-blind placebo-controlled cross-over design was employed, involving four experimental trials. Participants abstained from dietary caffeine sources for 4 days before the trials and ingested capsules (one in the morning and one in the afternoon) containing either placebo or caffeine (1.5 mg · kg(-1) body weight · day(-1)). On day 5, capsules containing placebo or caffeine (3 mg · kg(-1) body weight) were ingested 90 min before completing a time trial, equivalent to one hour of cycling at 75% peak sustainable power output. Hence the study was designed to incorporate placebo-placebo, placebo-caffeine, caffeine-placebo, and caffeine-caffeine conditions. Performance time was significantly improved after acute caffeine ingestion by 1:49 ± 1:41 min (3.0%, P = 0.021) following a withdrawal period (placebo-placebo vs. placebo-caffeine), and by 2:07 ± 1:28 min (3.6%, P = 0.002) following the non-withdrawal period (caffeine-placebo vs. caffeine-caffeine). No significant difference was detected between the two acute caffeine trials (placebo-caffeine vs. caffeine-caffeine). Average heart rate throughout exercise was significantly higher following acute caffeine administration compared with placebo. No differences were observed in ratings of perceived exertion between trials. A 3 mg · kg(-1) dose of caffeine significantly improves exercise performance irrespective of whether a 4-day withdrawal period is imposed on habitual caffeine users.

  7. Specific aspects of contemporary triathlon: implications for physiological analysis and performance.

    Science.gov (United States)

    Bentley, David J; Millet, Grégoire P; Vleck, Verónica E; McNaughton, Lars R

    2002-01-01

    Triathlon competitions are performed over markedly different distances and under a variety of technical constraints. In 'standard-distance' triathlons involving 1.5km swim, 40km cycling and 10km running, a World Cup series as well as a World Championship race is available for 'elite' competitors. In contrast, 'age-group' triathletes may compete in 5-year age categories at a World Championship level, but not against the elite competitors. The difference between elite and age-group races is that during the cycle stage elite competitors may 'draft' or cycle in a sheltered position; age-group athletes complete the cycle stage as an individual time trial. Within triathlons there are a number of specific aspects that make the physiological demands different from the individual sports of swimming, cycling and running. The physiological demands of the cycle stage in elite races may also differ compared with the age-group format. This in turn may influence performance during the cycle leg and subsequent running stage. Wetsuit use and drafting during swimming (in both elite and age-group races) result in improved buoyancy and a reduction in frontal resistance, respectively. Both of these factors will result in improved performance and efficiency relative to normal pool-based swimming efforts. Overall cycling performance after swimming in a triathlon is not typically affected. However, it is possible that during the initial stages of the cycle leg the ability of an athlete to generate the high power outputs necessary for tactical position changes may be impeded. Drafting during cycling results in a reduction in frontal resistance and reduced energy cost at a given submaximal intensity. The reduced energy expenditure during the cycle stage results in an improvement in running, so an athlete may exercise at a higher percentage of maximal oxygen uptake. In elite triathlon races, the cycle courses offer specific physiological demands that may result in different fatigue responses

  8. Spectrum-effect relationships between high performance liquid ...

    African Journals Online (AJOL)

    promoting effect on contractility of intestinal smooth was carried out to ... addition, the equation of spectrum-effect relationships {Y = 3.818 - 1.126X1 + ..... Peng W, Liu YJ, Wu N, Sun T, He XY, Gao YX, Wu CJ. ... Zheng QF, Zhao YL, Wang JB, Liu TT, Zhang B, Gong ... Zhao HY, Han X. Research thoughts and application.

  9. Tau Reconstruction, Identification Algorithms and Performance in ATLAS

    DEFF Research Database (Denmark)

    Simonyan, M.

    2013-01-01

    identification of hadronically decaying tau leptons is achieved by using detailed information from tracking and calorimeter detector components. Variables describing the properties of calorimeter energy deposits and track reconstruction within tau candidates are combined in multi-variate discriminants...... by investigating single hadron calorimeter response, as well as kinematic distributions in Z¿ tt events....

  10. Effect of respiratory muscle training on exercise performance in healthy individuals: a systematic review and meta-analysis.

    Science.gov (United States)

    Illi, Sabine K; Held, Ulrike; Frank, Irène; Spengler, Christina M

    2012-08-01

    Two distinct types of specific respiratory muscle training (RMT), i.e. respiratory muscle strength (resistive/threshold) and endurance (hyperpnoea) training, have been established to improve the endurance performance of healthy individuals. We performed a systematic review and meta-analysis in order to determine the factors that affect the change in endurance performance after RMT in healthy subjects. A computerized search was performed without language restriction in MEDLINE, EMBASE and CINAHL and references of original studies and reviews were searched for further relevant studies. RMT studies with healthy individuals assessing changes in endurance exercise performance by maximal tests (constant load, time trial, intermittent incremental, conventional [non-intermittent] incremental) were screened and abstracted by two independent investigators. A multiple linear regression model was used to identify effects of subjects' fitness, type of RMT (inspiratory or combined inspiratory/expiratory muscle strength training, respiratory muscle endurance training), type of exercise test, test duration and type of sport (rowing, running, swimming, cycling) on changes in performance after RMT. In addition, a meta-analysis was performed to determine the effect of RMT on endurance performance in those studies providing the necessary data. The multiple linear regression analysis including 46 original studies revealed that less fit subjects benefit more from RMT than highly trained athletes (6.0% per 10 mL · kg⁻¹ · min⁻¹ decrease in maximal oxygen uptake, 95% confidence interval [CI] 1.8, 10.2%; p = 0.005) and that improvements do not differ significantly between inspiratory muscle strength and respiratory muscle endurance training (p = 0.208), while combined inspiratory and expiratory muscle strength training seems to be superior in improving performance, although based on only 6 studies (+12.8% compared with inspiratory muscle strength training, 95% CI 3

  11. The Augmented Performer and the Performative Augmentation

    DEFF Research Database (Denmark)

    Kallionpaa, Maria; Gasselseder, Hans-Peter

    2016-01-01

    Composers, performers, and listeners usually regard musical compositions as unchangeable entities, which limits the composition techniques and decreases the originality of performers ́ interpretations, thus leading to a stagnation of classical music culture. The significance and possibilities of ...

  12. High performance work practices, innovation and performance

    DEFF Research Database (Denmark)

    Jørgensen, Frances; Newton, Cameron; Johnston, Kim

    2013-01-01

    Research spanning nearly 20 years has provided considerable empirical evidence for relationships between High Performance Work Practices (HPWPs) and various measures of performance including increased productivity, improved customer service, and reduced turnover. What stands out from......, and Africa to examine these various questions relating to the HPWP-innovation-performance relationship. Each paper discusses a practice that has been identified in HPWP literature and potential variables that can facilitate or hinder the effects of these practices of innovation- and performance...

  13. The Effect of Various Hot Environments on Physiological Responses and Information Processing Performance Following Firefighting Activities in a Smoke-Diving Room.

    Science.gov (United States)

    Hemmatjo, Rasoul; Motamedzade, Majid; Aliabadi, Mohsen; Kalatpour, Omid; Farhadian, Maryam

    2017-12-01

    Fire service workers often implement multiple duties in the emergency conditions, with such duties being mostly conducted in various ambient temperatures. The aim of the current study was to assess the firefighters' physiological responses, information processing, and working memory prior to and following simulated firefighting activities in three different hot environments. Seventeen healthy male firefighters performed simulated firefighting tasks in three separate conditions, namely (1) low heat (LH; 29-31°C, 55-60% relative humidity), (2) moderate heat (MH; 32-34°C, 55-60% relative humidity), and (3) severe heat (SH; 35-37°C, 55-60% relative humidity). It took about 45-50 minutes for each firefighter to finish all defined firefighting activities and the paced auditory serial addition test (PASAT). At the end of all the three experimental conditions, heart rate (HR) and tympanic temperature (TT) increased, while PASAT scores as a measure of information processing performance decreased relative to baseline. HR and TT were significantly higher at the end of the experiment in the SH (159.41 ± 4.25 beats/min; 38.22 ± 0.10°C) compared with the MH (156.59 ± 3.77 beats/min; 38.20 ± 0.10°C) and LH (154.24 ± 4.67 beats/min; 38.17 ± 0.10°C) conditions ( p   0.05). Nonetheless, there was a measurable difference in PASAT scores between LH and SH ( p  information processing and working memory during firefighting activity.

  14. Five Weeks of Sprint and High-Intensity Interval Training Improves Paddling Performance in Adolescent Surfers.

    Science.gov (United States)

    Farley, Oliver R L; Secomb, Josh L; Parsonage, Joanna R; Lundgren, Lina E; Abbiss, Chris R; Sheppard, Jeremy M

    2016-09-01

    Farley, ORL, Secomb, JL, Parsonage, JR, Lundgren, LE, Abbiss, CR, and Sheppard, JM. Five weeks of sprint and high-intensity interval training improves paddling performance in adolescent surfers. J Strength Cond Res 30(9): 2446-2452, 2016-The purpose of our study was to examine the effects of sprint interval training (SIT; 10 seconds) and high-intensity interval training (HIT; 30 seconds) on surfing athletes paddling performance (400-m time trial and repeat-sprint paddle performance). Twenty-four competitive adolescent surfers (19 male, 5 female; age = 14.4 ± 1.3 years, mass: 50.1 ± 10.7 kg, and stature: 159.9 ± 10.3 cm) were assigned to perform either 5 weeks of SIT and HIT. Participants completed a repeated-sprint paddle ability test (RSPT, 15-m surfboard sprint paddle initiated every 40 seconds × 10 bouts) and 400-m endurance surfboard paddle time trial before and after training. High-intensity interval training decreased the total time to complete the 400 m by 15.8 ± 16.1 seconds (p = 0.03), and SIT decreased the total time to complete the RSPT by 6.5 ± 4.3 seconds (p = 0.02). Fatigue index during the RSPT (first-slowest effort) was lower after HIT and SIT (p ≤ 0.001 and p = 0.02, respectively). There were no significant differences in performance changes in the 400 m (total time) and RSPT (total time, fastest 15 m time, and peak velocity) between HIT and SIT. Our study indicates that HIT and SIT may be implemented to the training program of surfers to improve aerobic and repeat-sprint paddle ability, both of which are identified as key aspects of the sport. In addition, these findings indicate that 400-m paddle and RSPT can discriminate between aerobic and anaerobic training adaptations, with aerobic gains likely from HIT and anaerobic gains from SIT.

  15. Living high-training low: effect on erythropoiesis and aerobic performance in highly-trained swimmers

    DEFF Research Database (Denmark)

    Robach, P.; Schmitt, L.; Brugniaux, J.V.

    2006-01-01

    LHTL enhances aerobic performance in athletes, and if any positive effect may last for up to 2 weeks after LHTL intervention. Eighteen swimmers trained for 13 days at 1,200 m while sleeping/living at 1,200 m in ambient air (control, n=9) or in hypoxic rooms (LHTL, n=9, 5 days at simulated altitude of 2......The "living high-training low" model (LHTL), i.e., training in normoxia but sleeping/living in hypoxia, is designed to improve the athletes performance. However, LHTL efficacy still remains controversial and also little is known about the duration of its potential benefit. This study tested whether......,500 m followed by 8 days at simulated altitude of 3,000 m, 16 h day(-1)). Measures were done before 1-2 days (POST-1) and 2 weeks after intervention (POST-15). Aerobic performance was assessed from two swimming trials, exploring .VO(2max) and endurance performance (2,000-m time trial), respectively...

  16. Caffeine improves performance in double poling during acute exposure to 2,000-m altitude.

    Science.gov (United States)

    Stadheim, H K; Nossum, E M; Olsen, R; Spencer, M; Jensen, J

    2015-12-15

    There is limited research on the physiological effects of caffeine (CAF) ingestion on exercise performance during acute hypoxia. The aim of the present study was therefore to test the effect of placebo (PLA) and CAF (4.5 mg/kg) on double poling (DP) performance during acute hypoxia. Thirteen male subelite cross-country skiers (V̇o2max 72.6 ± 5.68 ml·kg(-1)·min(-1)) were included. Performance was assessed as 1) an 8-km cross-country DP time-trial (C-PT), and 2) time until task failure at a set workload equal to ∼90% of DP V̇o2max. Testing was carried out in a hypobaric chamber, at 800 mbar (Pio2: ∼125 mmHg) corresponding to ∼2,000 m above sea level in a randomized double-blinded, placebo-controlled, cross-over design. CAF improved time to task failure from 6.10 ± 1.40 to 7.22 ± 1.30 min (P performance during acute exposure to altitude. Mechanisms underpinning improvements seem related to reduced pain RPE and increased heart rate during CAF C-PTs. Copyright © 2015 the American Physiological Society.

  17. Performing surgery: commonalities with performers outside medicine

    Directory of Open Access Journals (Sweden)

    Roger Lister Kneebone

    2016-08-01

    Full Text Available This paper argues for the inclusion of surgery within the canon of performance science. The world of medicine presents rich, complex but relatively under-researched sites of performance. Performative aspects of clinical practice are overshadowed by a focus on the processes and outcomes of medical care, such as diagnostic accuracy and the results of treatment. The primacy of this ‘clinical’ viewpoint - framed by clinical professionals as the application of medical knowledge - hides resonances with performance in other domains. Yet the language of performance is embedded in the culture of surgery - surgeons ‘perform’ operations, work in an operating ‘theatre’ and use ‘instruments’. This paper asks what might come into view if we take this performative language at face value and interrogate surgery from the perspective of performance science. It addresses the following questions: 1.To what extent and in what ways can surgical practice (both consultation and operation be considered as performance?2.How does comparison with two domains domains of non-surgical performance (close-up magic and puppetry illuminate understanding of surgical practice as performance?3.In what ways might including surgery within the canon of performance studies enrich the field of performance science?Two detailed case studies over 5 years with magicians (71.5 hours contact time and puppeteers (50.5 hours contact time identified performative aspects of surgical practice from the perspectives of professionals (as individuals or in groups and audiences. Physical simulation provided a means for non-clinicians to access and experience elements of the surgical world, acting as a prompt for discussion. Thematic analysis was used to establish themes and sub-themes.Key themes were: 1 clinical consultation can be viewed as ‘close-up live performance with a very small audience’ and 2 operative surgery can be viewed as ‘reading bodies within a dextrous team

  18. Java Performance Mysteries

    Directory of Open Access Journals (Sweden)

    Maldikar Pranita

    2016-01-01

    The contributions of this paper are (1 Observing Java performance mysteries in the cloud, (2 Identifying the sources of performance mysteries, and (3 Obtaining optimal and reproducible performance data.

  19. LTBP bridge performance primer.

    Science.gov (United States)

    2013-12-01

    "The performance of bridges is critical to the overall performance of the highway transportation system in the United States. However, many critical aspects of bridge performance are not well understood. The reasons for this include the extreme diver...

  20. Distributed performance counters

    Science.gov (United States)

    Davis, Kristan D; Evans, Kahn C; Gara, Alan; Satterfield, David L

    2013-11-26

    A plurality of first performance counter modules is coupled to a plurality of processing cores. The plurality of first performance counter modules is operable to collect performance data associated with the plurality of processing cores respectively. A plurality of second performance counter modules are coupled to a plurality of L2 cache units, and the plurality of second performance counter modules are operable to collect performance data associated with the plurality of L2 cache units respectively. A central performance counter module may be operable to coordinate counter data from the plurality of first performance counter modules and the plurality of second performance modules, the a central performance counter module, the plurality of first performance counter modules, and the plurality of second performance counter modules connected by a daisy chain connection.

  1. Communication through Performance: Hausa Performance Art ...

    African Journals Online (AJOL)

    The human voice is a natural instrument with a natural capability. Thus, speech with the aid of performance and music has been combined since earliest times to communicate valuable insights into human nature and universal themes of life. Such themes include life, death, good and evil. This paper examined performance ...

  2. Prognostic Performance Metrics

    Data.gov (United States)

    National Aeronautics and Space Administration — This chapter presents several performance metrics for offline evaluation of prognostics algorithms. A brief overview of different methods employed for performance...

  3. Design and performance of BWC replacement steam generators for PWR systems

    Energy Technology Data Exchange (ETDEWEB)

    Klarner, R.; Steinmoeller, F.; Millman, J.; Schneider, W. [Babcock and Wilcox Canada, Cambridge, Ontario (Canada)

    1998-07-01

    In recent years, Babcock and Wilcox Canada (BWC) has provided a number of PWR Replacement Steam Generators (RSGS) to replace units that had experienced extensive Alloy 600 tube degradation. BWC RSG units are in operation at Northeast Utilities' Millstone Unit 2, Rochester Gas and Electric's Ginna Station, Duke Energy's Catawba Unit 1, McGuire Unit 1 and 2, Florida Power and Light's St. Lucie Unit 1 and Commonwealth Edison's Byron 1 Station. Extensive start-up performance characteristics have been obtained for Millstone 2, Ginna, McGuire 1, and Catawba 1 RSGS. The Millstone 2, Ginna and Catawba 1 RSGs have also undergone extensive inspections following their first cycle of operation. The design and start-up performance characteristics of these RSGs are presented. The BWC Replacement Steam generators were designed to fit the existing envelope of pressure boundary dimensions to ensure licensability and integration into the Nuclear Steam Supply System. The RSGs were provided with a tube bundle of Alloy 690TT tubing, sized to match or exceed the original steam generator (OSG) thermal performance including provision for the reduced thermal conductivity of Alloy 690 relative to Alloy 600. The RSG tube bundle configurations provide a higher circulation design relative to the OSG, and feature corrosion resistant lattice grid and U-bend tube supports which provide effective anti-vibration support. The tube bundle supports accommodate relatively unobstructed flow and allow unrestrained structural interactions during thermal transients. Efficient steam separators assure low moisture carryover as well as high circulation. Performance measurements obtained during start-up verify that the BWC RSGs meet or exceed the specified thermal and moisture carryover performance requirements. RSG water level stability results at nor-mal operation and during plant transients have been excellent. Visual and ECT inspections have confirmed minimal deposition and 100

  4. Design and performance of BWC replacement steam generators for PWR systems

    International Nuclear Information System (INIS)

    Klarner, R.; Steinmoeller, F.; Millman, J.; Schneider, W.

    1998-01-01

    In recent years, Babcock and Wilcox Canada (BWC) has provided a number of PWR Replacement Steam Generators (RSGS) to replace units that had experienced extensive Alloy 600 tube degradation. BWC RSG units are in operation at Northeast Utilities' Millstone Unit 2, Rochester Gas and Electric's Ginna Station, Duke Energy's Catawba Unit 1, McGuire Unit 1 and 2, Florida Power and Light's St. Lucie Unit 1 and Commonwealth Edison's Byron 1 Station. Extensive start-up performance characteristics have been obtained for Millstone 2, Ginna, McGuire 1, and Catawba 1 RSGS. The Millstone 2, Ginna and Catawba 1 RSGs have also undergone extensive inspections following their first cycle of operation. The design and start-up performance characteristics of these RSGs are presented. The BWC Replacement Steam generators were designed to fit the existing envelope of pressure boundary dimensions to ensure licensability and integration into the Nuclear Steam Supply System. The RSGs were provided with a tube bundle of Alloy 690TT tubing, sized to match or exceed the original steam generator (OSG) thermal performance including provision for the reduced thermal conductivity of Alloy 690 relative to Alloy 600. The RSG tube bundle configurations provide a higher circulation design relative to the OSG, and feature corrosion resistant lattice grid and U-bend tube supports which provide effective anti-vibration support. The tube bundle supports accommodate relatively unobstructed flow and allow unrestrained structural interactions during thermal transients. Efficient steam separators assure low moisture carryover as well as high circulation. Performance measurements obtained during start-up verify that the BWC RSGs meet or exceed the specified thermal and moisture carryover performance requirements. RSG water level stability results at nor-mal operation and during plant transients have been excellent. Visual and ECT inspections have confirmed minimal deposition and 100% tube integrity following

  5. Aerodynamics of a Cycling Team in a Time Trial: Does the Cyclist at the Front Benefit?

    Science.gov (United States)

    Iniguez-de-la Torre, A.; Iniguez, J.

    2009-01-01

    When seasonal journeys take place in nature, birds and fishes migrate in groups. This provides them not only with security but also a considerable saving of energy. The power they need to travel requires overcoming aerodynamic or hydrodynamic drag forces, which can be substantially reduced when the group travels in an optimal arrangement. Also in…

  6. The effect of mountain bike wheel size on cross-country performance.

    Science.gov (United States)

    Hurst, Howard Thomas; Sinclair, Jonathan; Atkins, Stephen; Rylands, Lee; Metcalfe, John

    2017-07-01

    The purpose of this study was to determine the influence of different wheel size diameters on indicators of cross-country mountain bike time trial performance. Nine competitive male mountain bikers (age 34.7 ± 10.7 years; stature 177.7 ± 5.6 cm; body mass 73.2 ± 8.6 kg) performed 1 lap of a 3.48 km mountain bike (MTB) course as fast as possible on 26″, 27.5″ and 29″ wheeled MTB. Time (s), mean power (W), cadence (revs · min -1 ) and velocity (km · h -1 ) were recorded for the whole lap and during ascent and descent sections. One-way repeated measure ANOVA was used to determine significant differences. Results revealed no significant main effects for any variables by wheel size during all trials, with the exception of cadence during the descent (F (2, 16)  = 8.96; P = .002; P 2  = .53). Post hoc comparisons revealed differences lay between the 26″ and 29″ wheels (P = .02). The findings indicate that wheel size does not significantly influence performance during cross-country when ridden by trained mountain bikers, and that wheel choice is likely due to personal choice or sponsorship commitments.

  7. Effects of oral rehydration and external cooling on physiology, perception, and performance in hot, dry climates.

    Science.gov (United States)

    Muñoz, C X; Carney, K R; Schick, M K; Coburn, J W; Becker, A J; Judelson, D A

    2012-12-01

    Only limited research evaluates possible benefits of combined drinking and external cooling (by pouring cold water over the body) during exercise. Therefore, this study examined cold water drinking and external cooling on physiological, perceptual, and performance variables in hot, dry environments. Ten male runners completed four trials of walking 90 min at 30% VO(2max) followed by running a 5-km time trial in 33 ± 1 °C and 30 ± 4% relative humidity. Trials examined no intervention (CON), oral rehydration (OR), external cooling (EC), and oral rehydration plus external cooling (OR + EC). Investigators measured rectal temperature, skin temperatures, heart rate, thirst, thermal sensation, and ratings of perceived exertion (RPE). Oral rehydration (OR and OR + EC) significantly lowered heart rate (P External cooling (EC and OR + EC) significantly reduced chest and thigh temperature (P external cooling (CON and OR) during low-intensity exercise. Performance exhibited no differences (CON = 23.86 ± 4.57 min, OR = 22.74 ± 3.20 min, EC = 22.96 ± 3.11 min, OR + EC = 22.64 ± 3.73 min, P = 0.379). Independent of OR, pouring cold water on the body benefited skin temperature, thermal sensation, and RPE during low-intensity exercise in hot, dry conditions but failed to influence high-intensity performance. © 2012 John Wiley & Sons A/S.

  8. Effect of hydrotherapy on recovery from fatigue.

    Science.gov (United States)

    Vaile, J; Halson, S; Gill, N; Dawson, B

    2008-07-01

    The present study investigated the effects of three hydrotherapy interventions on next day performance recovery following strenuous training. Twelve cyclists completed four experimental trials differing only in 14-min recovery intervention: cold water immersion (CWI), hot water immersion (HWI), contrast water therapy (CWT), or passive recovery (PAS). Each trial comprised five consecutive exercise days of 105-min duration, including 66 maximal effort sprints. Additionally, subjects performed a total of 9-min sustained effort (time trial - TT). After completing each exercise session, athletes performed one of four recovery interventions (randomly assigned to each trial). Performance (average power), core temperature, heart rate (HR), and rating of perceived exertion (RPE) were recorded throughout each session. Sprint (0.1 - 2.2 %) and TT (0.0 - 1.7 %) performance were enhanced across the five-day trial following CWI and CWT, when compared to HWI and PAS. Additionally, differences in rectal temperature were observed between interventions immediately and 15-min post-recovery; however, no significant differences were observed in HR or RPE regardless of day of trial/intervention. Overall, CWI and CWT appear to improve recovery from high-intensity cycling when compared to HWI and PAS, with athletes better able to maintain performance across a five-day period.

  9. Search for Direct Top Squark Pair Production with the ATLAS Experiment and Studies of the Primary Vertex Reconstruction Performance

    CERN Document Server

    Abulaiti, Yiming

    The ATLAS detector is one of the two largest experiments installed at the Large Hadron Collider at CERN, the European Organization for Nuclear Research. During the first run, the ATLAS detector recorded data at centre of mass energies of 7 TeV and 8 TeV, enabling many precision measurements and new physics searches. One important task in ATLAS is measuring the primary vertex, the interaction point of the hardest proton-proton collision in an event. In this thesis, a study of the primary vertex reconstruction performance in data and simulated events using tt ̄ and Z events is presented. Within the statistics available, the performance in data and simulated events is found to be compatible. Motivated by the limitations of the Standard Model of particle physics, searches for supersymmetric particles are performed with the ATLAS experiment. No signal has been observed so far, and the results are used to set exclusion limits on the masses of the supersymmetric particles. As the exclusion limits are derived from a...

  10. Performance na contemporaneidade

    Directory of Open Access Journals (Sweden)

    Yiftah Peled

    2012-01-01

    Full Text Available Analisam-se aqui projetos de arte contemporânea, identificando estratégias de incorporação, deslocamento e participação do público que remetem a uma ampliação da arte da performance. O estudo propõe termos para definir tais estratégias como: performance animada, ready-made performático, performance do agente ficcional, dinâmicas e trocas entre estados de performance, performance íntima e performance interna.

  11. Human Computer Music Performance

    OpenAIRE

    Dannenberg, Roger B.

    2012-01-01

    Human Computer Music Performance (HCMP) is the study of music performance by live human performers and real-time computer-based performers. One goal of HCMP is to create a highly autonomous artificial performer that can fill the role of a human, especially in a popular music setting. This will require advances in automated music listening and understanding, new representations for music, techniques for music synchronization, real-time human-computer communication, music generation, sound synt...

  12. A review of caffeine's effects on cognitive, physical and occupational performance.

    Science.gov (United States)

    McLellan, Tom M; Caldwell, John A; Lieberman, Harris R

    2016-12-01

    Caffeine is consumed by over 80% of U.S. adults. This review examines the effects caffeine has on cognitive and physical function, since most real-world activities require complex decision making, motor processing and movement. Caffeine exerts its effects by blocking adenosine receptors. Following low (∼40mg or ∼0.5mgkg -1 ) to moderate (∼300mg or 4mgkg -1 ) caffeine doses, alertness, vigilance, attention, reaction time and attention improve, but less consistent effects are observed on memory and higher-order executive function, such as judgment and decision making. Effects on physical performance on a vast array of physical performance metrics such as time-to-exhaustion, time-trial, muscle strength and endurance, and high-intensity sprints typical of team sports are evident following doses that exceed about 200mg (∼3mgkg -1 ). Many occupations, including military, first responders, transport workers and factory shift workers, require optimal physical and cognitive function to ensure success, workplace safety and productivity. In these circumstances, that may include restricted sleep, repeated administration of caffeine is an effective strategy to maintain physical and cognitive capabilities. Published by Elsevier Ltd.

  13. Pavement Subgrade Performance Study

    DEFF Research Database (Denmark)

    Zhang, Wei; Ullidtz, Per; Macdonald, Robin

    1998-01-01

    The report describes the second test in the Danish Road Testing Machine (RTM) under the International Pavement Subgrade Performance Study. Pavement response was measured in different layers, and compared to different theroretical values. Performance in terms of plastic strains, rutting...

  14. Developing Effective Performance Measures

    Science.gov (United States)

    2014-10-14

    University When Performance Measurement Goes Bad Laziness Vanity Narcissism Too Many Pettiness Inanity 52 Developing Effective...Kasunic, October 14, 2014 © 2014 Carnegie Mellon University Narcissism Measuring performance from the organization’s point of view, rather than from

  15. Performance SNAPSHOT Reports

    Data.gov (United States)

    Department of Housing and Urban Development — The HOME Program Performance SNAPSHOTs are quarterly cumulative performance reports, which can be useful in tracking the HOME program progress of participating...

  16. Winter maintenance performance measure.

    Science.gov (United States)

    2016-01-01

    The Winter Performance Index is a method of quantifying winter storm events and the DOTs response to them. : It is a valuable tool for evaluating the States maintenance practices, performing post-storm analysis, training : maintenance personnel...

  17. Tracker Performance Metric

    National Research Council Canada - National Science Library

    Olson, Teresa; Lee, Harry; Sanders, Johnnie

    2002-01-01

    .... We have developed the Tracker Performance Metric (TPM) specifically for this purpose. It was designed to measure the output performance, on a frame-by-frame basis, using its output position and quality...

  18. HOPWA Performance Profiles

    Data.gov (United States)

    Department of Housing and Urban Development — HOPWA Performance Profiles are generated quarterly for all agencies receiving HOPWA formula or competitive grants. Performance Profiles are available at the national...

  19. R high performance programming

    CERN Document Server

    Lim, Aloysius

    2015-01-01

    This book is for programmers and developers who want to improve the performance of their R programs by making them run faster with large data sets or who are trying to solve a pesky performance problem.

  20. Mapping Intermediality in Performance

    NARCIS (Netherlands)

    2010-01-01

    Mapping Intermediality in Performance benadert het vraagstuk van intermedialiteit met betrekking tot performance (vooral theater) vanuit vijf verschillende invalshoeken: performativiteit en lichaam; tijd en ruimte; digitale cultuur en posthumanisme; netwerken; pedagogiek en praxis. In deze boeiende

  1. Dan Performer Mei Lanfang

    DEFF Research Database (Denmark)

    Risum, Janne

    2010-01-01

    The convention of performing female characters (dan characters) in Beijing opera, as practised by its most prominent male performer of female characters Mei Lanfang, and its and his cultural context and aesthetic aim...

  2. Performance measurement and pay for performance

    NARCIS (Netherlands)

    Tuijl, van H.F.J.M.; Kleingeld, P.A.M.; Algera, J.A.; Rutten, M.L.; Sonnentag, S.

    2002-01-01

    This chapter, which takes a (re)design perspective, focuses on the management of employees’ contributions to organisational goal attainment. The control loop for the self-regulation of task performance is used as a frame of reference. Several subsets of design requirements are described and related