WorldWideScience

Sample records for time specific objectives

  1. Specification of Concurrent Objects

    DEFF Research Database (Denmark)

    Sørensen, Morten U.

    relation over two objects and an event. In the model, objects can be composed by parallel composition, encapsulation, and hiding of operations. Refinement between objects is defined as fair trace inclusion.A specification language is presented where objects can be specified operationally by abstract...

  2. Objective measures for detecting the auditory brainstem response: comparisons of specificity, sensitivity and detection time

    DEFF Research Database (Denmark)

    Chesnaye, M. A.; Bell, S. L.; Harte, J. M.

    2018-01-01

    of the Hotelling's T-2 test (applied in either time or frequency domain), two versions of the modified q-sample uniform scores test and both the Fsp and Fmp, which were evaluated using both conventional F-distributions with assumed degrees of freedom and a bootstrap approach. Study sample: Data consisted of click......-level when evaluating statistical significance using the bootstrap approach, as opposed to using conventional F-distributions. The FPRs of the remaining methods were slightly higher than expected. Conclusions: In this work, Hotelling's T-2 outperformed the alternative methods for automatically detecting ABRs......-evoked ABRs and recordings of EEG background activity from 12 to 17 normal hearing adults, respectively. Results: An overall advantage in sensitivity and detection time was demonstrated for the Hotelling's T-2 test. The false-positive rates (FPRs) of the Fsp and Fmp were also closer to the nominal alpha...

  3. Ranking Specific Sets of Objects.

    Science.gov (United States)

    Maly, Jan; Woltran, Stefan

    2017-01-01

    Ranking sets of objects based on an order between the single elements has been thoroughly studied in the literature. In particular, it has been shown that it is in general impossible to find a total ranking - jointly satisfying properties as dominance and independence - on the whole power set of objects. However, in many applications certain elements from the entire power set might not be required and can be neglected in the ranking process. For instance, certain sets might be ruled out due to hard constraints or are not satisfying some background theory. In this paper, we treat the computational problem whether an order on a given subset of the power set of elements satisfying different variants of dominance and independence can be found, given a ranking on the elements. We show that this problem is tractable for partial rankings and NP-complete for total rankings.

  4. Real-time specifications

    DEFF Research Database (Denmark)

    David, A.; Larsen, K.G.; Legay, A.

    2015-01-01

    A specification theory combines notions of specifications and implementations with a satisfaction relation, a refinement relation, and a set of operators supporting stepwise design. We develop a specification framework for real-time systems using Timed I/O Automata as the specification formalism......, with the semantics expressed in terms of Timed I/O Transition Systems. We provide constructs for refinement, consistency checking, logical and structural composition, and quotient of specifications-all indispensable ingredients of a compositional design methodology. The theory is implemented in the new tool Ecdar...

  5. Parallel object-oriented specification language

    NARCIS (Netherlands)

    Florescu, O.; Voeten, J.P.M.; Theelen, B.D.; Geilen, M.C.W.; Corporaal, H.; Burns, Alan

    2008-01-01

    The Parallel Object-Oriented Specification Language (POOSL) is an expressive modelling language for hardware/software systems [10]. It was originally defined in [7] as an object-oriented extension of process algebra CCS [6], supporting (conditional) synchronous message passing between

  6. The Timing of Visual Object Categorization

    Science.gov (United States)

    Mack, Michael L.; Palmeri, Thomas J.

    2011-01-01

    An object can be categorized at different levels of abstraction: as natural or man-made, animal or plant, bird or dog, or as a Northern Cardinal or Pyrrhuloxia. There has been growing interest in understanding how quickly categorizations at different levels are made and how the timing of those perceptual decisions changes with experience. We specifically contrast two perspectives on the timing of object categorization at different levels of abstraction. By one account, the relative timing implies a relative timing of stages of visual processing that are tied to particular levels of object categorization: Fast categorizations are fast because they precede other categorizations within the visual processing hierarchy. By another account, the relative timing reflects when perceptual features are available over time and the quality of perceptual evidence used to drive a perceptual decision process: Fast simply means fast, it does not mean first. Understanding the short-term and long-term temporal dynamics of object categorizations is key to developing computational models of visual object recognition. We briefly review a number of models of object categorization and outline how they explain the timing of visual object categorization at different levels of abstraction. PMID:21811480

  7. Object specific reconstruction using compressively sensed data

    International Nuclear Information System (INIS)

    Mahalanobis, Abhijit

    2008-01-01

    Compressed sensing holds the promise for radically novel sensors that can perfectly reconstruct images using considerably less samples of data than required by the otherwise general Shannon sampling theorem. In surveillance systems however, it is also desirable to cue regions of the image where objects of interest may exist. Thus in this paper, we are interested in imaging interesting objects in a scene, without necessarily seeking perfect reconstruction of the whole image. We show that our goals are achieved by minimizing a modified L2-norm criterion with good results when the reconstruction of only specific objects is of interest. The method yields a simple closed form analytical solution that does not require iterative processing. Objects can be meaningfully sensed in considerable detail while heavily compressing the scene elsewhere. Essentially, this embeds the object detection and clutter discrimination function in the sensing and imaging process.

  8. Cockpit management and Specific Behavioral Objectives (SBOs)

    Science.gov (United States)

    Mudge, R. W.

    1987-01-01

    One of the primary tools used to accomplish the task of effective training is the specific behavioral objective (SBO). An SBO is simply a statement which specifically identifies a small segment of the final behavior sought, and a little more. The key word is specific. The company pinpoints exactly what it is it wants the pilot to do after completing training, and what it should evaluate from the point of view of both the program and the pilot. It tells the junior crewmember exactly, specifically, what he should monitor and support insofar as the management function is concerned. It gives greater meaning to the term second in command. And finally, it tells the supervisory pilot exactly what he should observe, evaluate, and instruct, insofar as the management function is concerned.

  9. Visual object recognition and category-specificity

    DEFF Research Database (Denmark)

    Gerlach, Christian

    This thesis is based on seven published papers. The majority of the papers address two topics in visual object recognition: (i) category-effects at pre-semantic stages, and (ii) the integration of visual elements into elaborate shape descriptions corresponding to whole objects or large object parts...... (shape configuration). In the early writings these two topics were examined more or less independently. In later works, findings concerning category-effects and shape configuration merge into an integrated model, termed RACE, advanced to explain category-effects arising at pre-semantic stages in visual...... in visual long-term memory. In the thesis it is described how this simple model can account for a wide range of findings on category-specificity in both patients with brain damage and normal subjects. Finally, two hypotheses regarding the neural substrates of the model's components - and how activation...

  10. Category-specificity in visual object recognition

    DEFF Research Database (Denmark)

    Gerlach, Christian

    2009-01-01

    Are all categories of objects recognized in the same manner visually? Evidence from neuropsychology suggests they are not: some brain damaged patients are more impaired in recognizing natural objects than artefacts whereas others show the opposite impairment. Category-effects have also been...... demonstrated in neurologically intact subjects, but the findings are contradictory and there is no agreement as to why category-effects arise. This article presents a Pre-semantic Account of Category Effects (PACE) in visual object recognition. PACE assumes two processing stages: shape configuration (the...... binding of shape elements into elaborate shape descriptions) and selection (among competing representations in visual long-term memory), which are held to be differentially affected by the structural similarity between objects. Drawing on evidence from clinical studies, experimental studies...

  11. Category-specificity in visual object recognition

    DEFF Research Database (Denmark)

    Gerlach, Christian

    2009-01-01

    binding of shape elements into elaborate shape descriptions) and selection (among competing representations in visual long-term memory), which are held to be differentially affected by the structural similarity between objects. Drawing on evidence from clinical studies, experimental studies...

  12. The Reviewing of Object Files: Object-Specific Integration of Information.

    Science.gov (United States)

    Kahneman, Daniel; And Others

    1992-01-01

    Seven experiments involving a total of 203 college students explored a form of object-specific priming and established a robust object-specific benefit that indicates that a new stimulus will be named faster if it physically matches a previous stimulus seen as part of the same perceptual object. (SLD)

  13. Object marking in Swahili: Definiteness, specificity, or both ...

    African Journals Online (AJOL)

    This article examines the role of object marking in relation to definiteness and specificity in Swahili. Object marking in general has attracted the attention of many scholars in the field of Bantu linguistics due to the complex nature of object markers (OMs) and varying functions they fulfil in Bantu. Opinions differ on the role of ...

  14. General object recognition is specific: Evidence from novel and familiar objects.

    Science.gov (United States)

    Richler, Jennifer J; Wilmer, Jeremy B; Gauthier, Isabel

    2017-09-01

    In tests of object recognition, individual differences typically correlate modestly but nontrivially across familiar categories (e.g. cars, faces, shoes, birds, mushrooms). In theory, these correlations could reflect either global, non-specific mechanisms, such as general intelligence (IQ), or more specific mechanisms. Here, we introduce two separate methods for effectively capturing category-general performance variation, one that uses novel objects and one that uses familiar objects. In each case, we show that category-general performance variance is unrelated to IQ, thereby implicating more specific mechanisms. The first approach examines three newly developed novel object memory tests (NOMTs). We predicted that NOMTs would exhibit more shared, category-general variance than familiar object memory tests (FOMTs) because novel objects, unlike familiar objects, lack category-specific environmental influences (e.g. exposure to car magazines or botany classes). This prediction held, and remarkably, virtually none of the substantial shared variance among NOMTs was explained by IQ. Also, while NOMTs correlated nontrivially with two FOMTs (faces, cars), these correlations were smaller than among NOMTs and no larger than between the face and car tests themselves, suggesting that the category-general variance captured by NOMTs is specific not only relative to IQ, but also, to some degree, relative to both face and car recognition. The second approach averaged performance across multiple FOMTs, which we predicted would increase category-general variance by averaging out category-specific factors. This prediction held, and as with NOMTs, virtually none of the shared variance among FOMTs was explained by IQ. Overall, these results support the existence of object recognition mechanisms that, though category-general, are specific relative to IQ and substantially separable from face and car recognition. They also add sensitive, well-normed NOMTs to the tools available to study

  15. Real time natural object modeling framework

    International Nuclear Information System (INIS)

    Rana, H.A.; Shamsuddin, S.M.; Sunar, M.H.

    2008-01-01

    CG (Computer Graphics) is a key technology for producing visual contents. Currently computer generated imagery techniques are being developed and applied, particularly in the field of virtual reality applications, film production, training and flight simulators, to provide total composition of realistic computer graphic images. Natural objects like clouds are an integral feature of the sky without them synthetic outdoor scenes seem unrealistic. Modeling and animating such objects is a difficult task. Most systems are difficult to use, as they require adjustment of numerous, complex parameters and are non-interactive. This paper presents an intuitive, interactive system to artistically model, animate, and render visually convincing clouds using modern graphics hardware. A high-level interface models clouds through the visual use of cubes. Clouds are rendered by making use of hardware accelerated API -OpenGL. The resulting interactive design and rendering system produces perceptually convincing cloud models that can be used in any interactive system. (author)

  16. New Results on Timed Specifications

    DEFF Research Database (Denmark)

    Bourke, Timothy; David, Alexandre; Larsen, Kim Guldstrand

    2010-01-01

    Recently, we have proposed a new design theory for timed systems. This theory, building on Timed I/O Automata with game semantics, includes clas- sical operators like satisfaction, consistency, logical composition and structural composition. This paper presents a new efficient algorithm for check...

  17. Remote Testing of Timed Specifications

    DEFF Research Database (Denmark)

    David, Alexandre; Larsen, Kim Guldstrand; Mikucionis, Marius

    2013-01-01

    We present a study and a testing framework on black box remote testing of real-time systems using UPPAAL TIGA. One of the essential challenges of remote testing is the communication latency between the Tester and the System Under Test (IUT) that may lead to interleaving of inputs and outputs. Thi...

  18. A comparison of moving object detection methods for real-time moving object detection

    Science.gov (United States)

    Roshan, Aditya; Zhang, Yun

    2014-06-01

    Moving object detection has a wide variety of applications from traffic monitoring, site monitoring, automatic theft identification, face detection to military surveillance. Many methods have been developed across the globe for moving object detection, but it is very difficult to find one which can work globally in all situations and with different types of videos. The purpose of this paper is to evaluate existing moving object detection methods which can be implemented in software on a desktop or laptop, for real time object detection. There are several moving object detection methods noted in the literature, but few of them are suitable for real time moving object detection. Most of the methods which provide for real time movement are further limited by the number of objects and the scene complexity. This paper evaluates the four most commonly used moving object detection methods as background subtraction technique, Gaussian mixture model, wavelet based and optical flow based methods. The work is based on evaluation of these four moving object detection methods using two (2) different sets of cameras and two (2) different scenes. The moving object detection methods have been implemented using MatLab and results are compared based on completeness of detected objects, noise, light change sensitivity, processing time etc. After comparison, it is observed that optical flow based method took least processing time and successfully detected boundary of moving objects which also implies that it can be implemented for real-time moving object detection.

  19. Tracking multiple objects is limited only by object spacing, not by speed, time, or capacity.

    Science.gov (United States)

    Franconeri, S L; Jonathan, S V; Scimeca, J M

    2010-07-01

    In dealing with a dynamic world, people have the ability to maintain selective attention on a subset of moving objects in the environment. Performance in such multiple-object tracking is limited by three primary factors-the number of objects that one can track, the speed at which one can track them, and how close together they can be. We argue that this last limit, of object spacing, is the root cause of all performance constraints in multiple-object tracking. In two experiments, we found that as long as the distribution of object spacing is held constant, tracking performance is unaffected by large changes in object speed and tracking time. These results suggest that barring object-spacing constraints, people could reliably track an unlimited number of objects as fast as they could track a single object.

  20. Category Specificity in Normal Episodic Learning: Applications to Object Recognition and Category-Specific Agnosia

    Science.gov (United States)

    Bukach, Cindy M.; Bub, Daniel N.; Masson, Michael E. J.; Lindsay, D. Stephen

    2004-01-01

    Studies of patients with category-specific agnosia (CSA) have given rise to multiple theories of object recognition, most of which assume the existence of a stable, abstract semantic memory system. We applied an episodic view of memory to questions raised by CSA in a series of studies examining normal observers' recall of newly learned attributes…

  1. Time and multiple objectives in scheduling and routing problems

    NARCIS (Netherlands)

    Dabia, S.

    2012-01-01

    Many optimization problems encountered in practice are multi-objective by nature, i.e., different objectives are conflicting and equally important. Many times, it is not desirable to drop some of them or to optimize them in a composite single objective or hierarchical manner. Furthermore, cost

  2. Modular specification of real-time systems

    DEFF Research Database (Denmark)

    Inal, Recep

    1994-01-01

    Duration Calculus, a real-time interval logic, has been embedded in the Z specification language to provide a notation for real-time systems that combines the modularisation and abstraction facilities of Z with a logic suitable for reasoning about real-time properties. In this article the notation...

  3. RTDB: A memory resident real-time object database

    International Nuclear Information System (INIS)

    Nogiec, Jerzy M.; Desavouret, Eugene

    2003-01-01

    RTDB is a fast, memory-resident object database with built-in support for distribution. It constitutes an attractive alternative for architecting real-time solutions with multiple, possibly distributed, processes or agents sharing data. RTDB offers both direct and navigational access to stored objects, with local and remote random access by object identifiers, and immediate direct access via object indices. The database supports transparent access to objects stored in multiple collaborating dispersed databases and includes a built-in cache mechanism that allows for keeping local copies of remote objects, with specifiable invalidation deadlines. Additional features of RTDB include a trigger mechanism on objects that allows for issuing events or activating handlers when objects are accessed or modified and a very fast, attribute based search/query mechanism. The overall architecture and application of RTDB in a control and monitoring system is presented

  4. Dynamic Scheduling of Object Invocations in Distributed Object Oriented Real-Time Systems

    DEFF Research Database (Denmark)

    Jørgensen, Bo Nørregaard; Joosen, Wouter

    1998-01-01

    This paper describes some of the issues that we investigate in order to develop distributed object computing middleware for application domains where timely cooperation and coordination between objects are crucial for guaranteeing correct system behavior. In particular, issues on admission contro...

  5. Linking actions and objects: Context-specific learning of novel weight priors.

    Science.gov (United States)

    Trewartha, Kevin M; Flanagan, J Randall

    2017-06-01

    Distinct explicit and implicit memory processes support weight predictions used when lifting objects and making perceptual judgments about weight, respectively. The first time that an object is encountered weight is predicted on the basis of learned associations, or priors, linking size and material to weight. A fundamental question is whether the brain maintains a single, global representation of priors, or multiple representations that can be updated in a context specific way. A second key question is whether the updating of priors, or the ability to scale lifting forces when repeatedly lifting unusually weighted objects requires focused attention. To investigate these questions we compared the adaptability of weight predictions used when lifting objects and judging their weights in different groups of participants who experienced size-weight inverted objects passively (with the objects placed on the hands) or actively (where participants lift the objects) under full or divided attention. To assess weight judgments we measured the size-weight illusion after every 20 trials of experience with the inverted objects both passively and actively. The attenuation of the illusion that arises when lifting inverted object was found to be context-specific such that the attenuation was larger when the mode of interaction with the inverted objects matched the method of assessment of the illusion. Dividing attention during interaction with the inverted objects had no effect on attenuation of the illusion, but did slow the rate at which lifting forces were scaled to the weight inverted objects. These findings suggest that the brain stores multiple representations of priors that are context specific, and that focused attention is important for scaling lifting forces, but not for updating weight predictions used when judging object weight. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Spanish Tourist Behaviour: A Specific Objective-base Segmantation

    OpenAIRE

    González, Pablo Rodríguez; Molina, Oscar

    2009-01-01

    This work uses data from the Spanish Tourism Demand Segments Survey (N=6900) conducted by the IESA-CSIC for Turismo Andaluz, SA. The objective of the paper is to develop a statistical segmentation or typology of Spanish tourists based on objective aspects of tourist behaviour measured in the survey including destinations visited, theme of the trip, lodging, transportation and travel group. Initial categorical data are reduced using multiple correspondence analysis and grouped through cluster ...

  7. Real-Time Video Stylization Using Object Flows.

    Science.gov (United States)

    Lu, Cewu; Xiao, Yao; Tang, Chi-Keung

    2017-05-05

    We present a real-time video stylization system and demonstrate a variety of painterly styles rendered on real video inputs. The key technical contribution lies on the object flow, which is robust to inaccurate optical flow, unknown object transformation and partial occlusion as well. Since object flows relate regions of the same object across frames, shower-door effect can be effectively reduced where painterly strokes and textures are rendered on video objects. The construction of object flows is performed in real time and automatically after applying metric learning. To reduce temporal flickering, we extend the bilateral filtering into motion bilateral filtering. We propose quantitative metrics to measure the temporal coherence on structures and textures of our stylized videos, and perform extensive experiments to compare our stylized results with baseline systems and prior works specializing in watercolor and abstraction.

  8. A Bayesian alternative for multi-objective ecohydrological model specification

    Science.gov (United States)

    Tang, Yating; Marshall, Lucy; Sharma, Ashish; Ajami, Hoori

    2018-01-01

    Recent studies have identified the importance of vegetation processes in terrestrial hydrologic systems. Process-based ecohydrological models combine hydrological, physical, biochemical and ecological processes of the catchments, and as such are generally more complex and parametric than conceptual hydrological models. Thus, appropriate calibration objectives and model uncertainty analysis are essential for ecohydrological modeling. In recent years, Bayesian inference has become one of the most popular tools for quantifying the uncertainties in hydrological modeling with the development of Markov chain Monte Carlo (MCMC) techniques. The Bayesian approach offers an appealing alternative to traditional multi-objective hydrologic model calibrations by defining proper prior distributions that can be considered analogous to the ad-hoc weighting often prescribed in multi-objective calibration. Our study aims to develop appropriate prior distributions and likelihood functions that minimize the model uncertainties and bias within a Bayesian ecohydrological modeling framework based on a traditional Pareto-based model calibration technique. In our study, a Pareto-based multi-objective optimization and a formal Bayesian framework are implemented in a conceptual ecohydrological model that combines a hydrological model (HYMOD) and a modified Bucket Grassland Model (BGM). Simulations focused on one objective (streamflow/LAI) and multiple objectives (streamflow and LAI) with different emphasis defined via the prior distribution of the model error parameters. Results show more reliable outputs for both predicted streamflow and LAI using Bayesian multi-objective calibration with specified prior distributions for error parameters based on results from the Pareto front in the ecohydrological modeling. The methodology implemented here provides insight into the usefulness of multiobjective Bayesian calibration for ecohydrologic systems and the importance of appropriate prior

  9. Real-time object-oriented programming: studies and proposals

    International Nuclear Information System (INIS)

    Fouquier, Gilles

    1996-01-01

    This thesis contributes to the introduction of real-time features in object-oriented programming. Object-oriented programming favours modularity and reusability. Therefore, its application to real-time introduces many theoretical and conceptual problems. To deal with these problems, a new real-time object-oriented programming model is presented. This model is based on the active object model which allows concurrence and maintains the encapsulation property. The real-time aspect is treated by replacing the concept of task by the concept of method processing and by associating a real-time constraint to each message (priority or deadline). The set of all the running methods is scheduled. This model, called ATOME, contains several sub-models to deal with the usual concurrence control integrating their priority and deadline processing. The classical HPF and EDF scheduling avoid priority or deadline inversion. This model and its variants are new proposals to program real-time applications in the object-oriented way, therefore easing reusability and code writing. The feasibility of this approach is demonstrated by extending and existing active object-based language to real-time, in using the rules defined in the ATOME model. (author) [fr

  10. Investigation of some specific industry objects effect on plants

    International Nuclear Information System (INIS)

    Kadirova, M.; Mukhamedshina, N. M.; Mirsagatova, A. A.; Norboev, N.; Amanov, M.; Baynazarov, B.; Khushvaktov, T.

    2001-01-01

    Such industry objects as metallurgical works, chemical fertilizers manufacture, automobile industry and others are contribute to contaminate an environment. For example, it is known, that aluminum factories throw out in an environment fluorine hydride, solid fluorides, nitrogen dioxide, sulpher dioxide, hydrocarbons, ions of heavy metals and others. For comparison of harmful action of various industrial objects on plants we had investigate some leaves and seed of plants grown in areas of Tadjik aluminum factory, Chirchik works of heatproof and refractory metals, Asaka automobile works and Tashkent nuclear reactor action. Investigations were conduct by nuclear techniques and by physical and agrotechnical ethods. The alternative methods have been used by Tashkent state agrarian university. High sensitive and reliable multielement instrumental neutron activation analysis (INAA) and X-ray radiometric techniques for determination of 27 elements in plant have been developed in the Institute of nuclear physics (INP)

  11. Objective specific beam generation for image guided robotic radiosurgery

    International Nuclear Information System (INIS)

    Schlaefer, A.; Jungmann, O.; Schweikard, A.; Kilby, W.

    2007-01-01

    Robotic radiosurgery enables precise dose delivery throughout the body. Planning for robotic radiosurgery comprises of finding a suitable set of beams and beam weights. The problem can be addressed by generating a large set of candidate beams, and selection of beams with nonzero weight by mathematical programming. We propose to use different randomized beam generation methods depending on the type of lesion and the clinical objective. Results for three patient cases indicate that this can improve the plan quality. (orig.)

  12. Objective specific beam generation for image guided robotic radiosurgery

    Energy Technology Data Exchange (ETDEWEB)

    Schlaefer, A.; Jungmann, O.; Schweikard, A. [Inst. for Robotics and Cognitive Systems, Univ. of Luebeck (Germany); Kilby, W. [Accuray Inc., Sunnyvale, CA (United States)

    2007-06-15

    Robotic radiosurgery enables precise dose delivery throughout the body. Planning for robotic radiosurgery comprises of finding a suitable set of beams and beam weights. The problem can be addressed by generating a large set of candidate beams, and selection of beams with nonzero weight by mathematical programming. We propose to use different randomized beam generation methods depending on the type of lesion and the clinical objective. Results for three patient cases indicate that this can improve the plan quality. (orig.)

  13. Humanoid Robotics: Real-Time Object Oriented Programming

    Science.gov (United States)

    Newton, Jason E.

    2005-01-01

    Programming of robots in today's world is often done in a procedural oriented fashion, where object oriented programming is not incorporated. In order to keep a robust architecture allowing for easy expansion of capabilities and a truly modular design, object oriented programming is required. However, concepts in object oriented programming are not typically applied to a real time environment. The Fujitsu HOAP-2 is the test bed for the development of a humanoid robot framework abstracting control of the robot into simple logical commands in a real time robotic system while allowing full access to all sensory data. In addition to interfacing between the motor and sensory systems, this paper discusses the software which operates multiple independently developed control systems simultaneously and the safety measures which keep the humanoid from damaging itself and its environment while running these systems. The use of this software decreases development time and costs and allows changes to be made while keeping results safe and predictable.

  14. Time-dependent inhomogeneous jet models for BL Lac objects

    Science.gov (United States)

    Marlowe, A. T.; Urry, C. M.; George, I. M.

    1992-05-01

    Relativistic beaming can explain many of the observed properties of BL Lac objects (e.g., rapid variability, high polarization, etc.). In particular, the broadband radio through X-ray spectra are well modeled by synchrotron-self Compton emission from an inhomogeneous relativistic jet. We have done a uniform analysis on several BL Lac objects using a simple but plausible inhomogeneous jet model. For all objects, we found that the assumed power-law distribution of the magnetic field and the electron density can be adjusted to match the observed BL Lac spectrum. While such models are typically unconstrained, consideration of spectral variability strongly restricts the allowed parameters, although to date the sampling has generally been too sparse to constrain the current models effectively. We investigate the time evolution of the inhomogeneous jet model for a simple perturbation propagating along the jet. The implications of this time evolution model and its relevance to observed data are discussed.

  15. Timing, timing, timing: Fast decoding of object information from intracranial field potentials in human visual cortex

    Science.gov (United States)

    Liu, Hesheng; Agam, Yigal; Madsen, Joseph R.; Kreiman, Gabriel

    2010-01-01

    Summary The difficulty of visual recognition stems from the need to achieve high selectivity while maintaining robustness to object transformations within hundreds of milliseconds. Theories of visual recognition differ in whether the neuronal circuits invoke recurrent feedback connections or not. The timing of neurophysiological responses in visual cortex plays a key role in distinguishing between bottom-up and top-down theories. Here we quantified at millisecond resolution the amount of visual information conveyed by intracranial field potentials from 912 electrodes in 11 human subjects. We could decode object category information from human visual cortex in single trials as early as 100 ms post-stimulus. Decoding performance was robust to depth rotation and scale changes. The results suggest that physiological activity in the temporal lobe can account for key properties of visual recognition. The fast decoding in single trials is compatible with feed-forward theories and provides strong constraints for computational models of human vision. PMID:19409272

  16. Deformation-specific and deformation-invariant visual object recognition: pose vs identity recognition of people and deforming objects

    Directory of Open Access Journals (Sweden)

    Tristan J Webb

    2014-04-01

    Full Text Available When we see a human sitting down, standing up, or walking, we can recognise one of these poses independently of the individual, or we can recognise the individual person, independently of the pose. The same issues arise for deforming objects. For example, if we see a flag deformed by the wind, either blowing out or hanging languidly, we can usually recognise the flag, independently of its deformation; or we can recognise the deformation independently of the identity of the flag. We hypothesize that these types of recognition can be implemented by the primate visual system using temporo-spatial continuity as objects transform as a learning principle. In particular, we hypothesize that pose or deformation can be learned under conditions in which large numbers of different people are successively seen in the same pose, or objects in the same deformation. We also hypothesize that person-specific representations that are independent of pose, and object-specific representations that are independent of deformation and view, could be built, when individual people or objects are observed successively transforming from one pose or deformation and view to another. These hypotheses were tested in a simulation of the ventral visual system, VisNet, that uses temporal continuity, implemented in a synaptic learning rule with a short-term memory trace of previous neuronal activity, to learn invariant representations. It was found that depending on the statistics of the visual input, either pose-specific or deformation-specific representations could be built that were invariant with respect to individual and view; or that identity-specific representations could be built that were invariant with respect to pose or deformation and view. We propose that this is how pose-specific and pose-invariant, and deformation-specific and deformation-invariant, perceptual representations are built in the brain.

  17. Race, time and folded objects: the HeLa error

    NARCIS (Netherlands)

    M'charek, A.

    2014-01-01

    Given their commitment to practices science studies have bestowed considerable attention upon objects. We have the boundary object, the standardized package, the network object, the immutable mobile, the fluid object, even a fire object has entered the scene. However, these objects do not provide us

  18. Enhancing State-of-the-art Multi-objective Optimization Algorithms by Applying Domain Specific Operators

    DEFF Research Database (Denmark)

    Ghoreishi, Newsha; Sørensen, Jan Corfixen; Jørgensen, Bo Nørregaard

    2015-01-01

    optimization problems where the environment does not change dynamically. For that reason, the requirement for convergence in static optimization problems is not as timecritical as for dynamic optimization problems. Most MOEAs use generic variables and operators that scale to static multi-objective optimization...... problem. The domain specific operators only encode existing knowledge about the environment. A comprehensive comparative study is provided to evaluate the results of applying the CONTROLEUM-GA compared to NSGAII, e-NSGAII and e- MOEA. Experimental results demonstrate clear improvements in convergence time...

  19. Methodology for object-oriented real-time systems analysis and design: Software engineering

    Science.gov (United States)

    Schoeffler, James D.

    1991-01-01

    Successful application of software engineering methodologies requires an integrated analysis and design life-cycle in which the various phases flow smoothly 'seamlessly' from analysis through design to implementation. Furthermore, different analysis methodologies often lead to different structuring of the system so that the transition from analysis to design may be awkward depending on the design methodology to be used. This is especially important when object-oriented programming is to be used for implementation when the original specification and perhaps high-level design is non-object oriented. Two approaches to real-time systems analysis which can lead to an object-oriented design are contrasted: (1) modeling the system using structured analysis with real-time extensions which emphasizes data and control flows followed by the abstraction of objects where the operations or methods of the objects correspond to processes in the data flow diagrams and then design in terms of these objects; and (2) modeling the system from the beginning as a set of naturally occurring concurrent entities (objects) each having its own time-behavior defined by a set of states and state-transition rules and seamlessly transforming the analysis models into high-level design models. A new concept of a 'real-time systems-analysis object' is introduced and becomes the basic building block of a series of seamlessly-connected models which progress from the object-oriented real-time systems analysis and design system analysis logical models through the physical architectural models and the high-level design stages. The methodology is appropriate to the overall specification including hardware and software modules. In software modules, the systems analysis objects are transformed into software objects.

  20. Objectively measured physical activity and sedentary time in youth

    DEFF Research Database (Denmark)

    Cooper, Ashley R; Goodman, Anna; Page, Angie S

    2015-01-01

    .8-18.4 years) who provided at least three days of valid accelerometer data. Linear regression was used to examine associations between age, sex, weight status, country and physical activity outcomes. RESULTS: Boys were less sedentary and more active than girls at all ages. After 5 years of age......BACKGROUND: Physical activity and sedentary behaviour in youth have been reported to vary by sex, age, weight status and country. However, supporting data are often self-reported and/or do not encompass a wide range of ages or geographical locations. This study aimed to describe objectively......-measured physical activity and sedentary time patterns in youth. METHODS: The International Children's Accelerometry Database (ICAD) consists of ActiGraph accelerometer data from 20 studies in ten countries, processed using common data reduction procedures. Analyses were conducted on 27,637 participants (2...

  1. Domain-Specific Self-Reported and Objectively Measured Physical Activity in Children

    Directory of Open Access Journals (Sweden)

    Ole Sprengeler

    2017-03-01

    Full Text Available Little is known about the extent that different domains contribute to total sedentary (SED, light (LPA and moderate-to-vigorous physical activity (MVPA. We aimed to identify domain-specific physical activity (PA patterns in school-aged children who were assessed by questionnaire and accelerometry. For the study, 298 German school children and adolescents aged 6–17 years wore an accelerometer for one week and completed a PA recall-questionnaire for the same period. Spearman coefficients (r were used to evaluate the agreement between self-reported and objectively measured PA in five domains (transport, school hours, physical education, leisure-time, organized sports activities. School hours mainly contributed to the total objectively measured SED, LPA and MVPA (55%, 53% and 46%, respectively, whilst sports activities contributed only 24% to total MVPA. Compared to accelerometry, the proportion of self-reported LPA and MVPA during school hours was substantially underestimated but overestimated during leisure-time. The agreement of self-reported and objectively measured PA was low for total LPA (r = 0.09, 95% CI (confidence interval: −0.03–0.20 and total MVPA (r = 0.21, 95% CI: 0.10–0.32, while moderate agreement was only found for total SED (r = 0.44, 95% CI: 0.34–0.53, LPA during transport (r = 0.59; 95% CI: 0.49–0.67 and MVPA during organized sports activities (r = 0.54; 95% CI: 0.38–0.67. Since school hours mainly contribute to total SED, LPA and MVPA and self-reported LPA and MVPA during school were importantly underestimated compared to objectively measured LPA and MVPA, the application of objective measurements is compulsory to characterize the entire activity pattern of school-aged children.

  2. Gender-Specificity in Viewing Time Among Heterosexual Women.

    Science.gov (United States)

    Xu, Yin; Rahman, Qazi; Zheng, Yong

    2017-07-01

    Measures of sexual interest tend to be more gender-specific in heterosexual men than in heterosexual women. Cognitive measures, such as viewing time to attractive stimuli, may also show similar patterns of gender-specificity or nonspecificity among men and women and thus serve as useful adjuncts to more direct measures of sexual interest. The objectives of the present research were to determine the extent of gender-specificity in women's viewing times for female pictures (varying in their perceived physical attractiveness) and explore the influence of social comparison of physical appearance on these patterns of responses. In Study 1, we recorded only women's viewing times for pictures of both genders, measured self-reported menstrual cycle phase, and manipulated the waist-to-hip ratio of the women in the female pictures. In Study 2, we recorded women's and men's viewing times, self-reported sexual attraction to pictures of males and females, and physical appearance social comparison. Study 1 found that heterosexual women's viewing time toward female pictures was not associated with manipulation of the perceived attractiveness of those pictures. Study 2 found that heterosexual men were more gender-specific than heterosexual women in their viewing time patterns. We also found that reported sexual attraction and physical appearance social comparison were associated with heterosexual women's viewing times for female pictures, while heterosexual men's viewing times were associated with sexual attraction only. Our results are discussed in relation to the utility of viewing time as an indicator of visual attention toward attractive or sexually appealing visual stimuli.

  3. Real-time object detection, tracking and occlusion reasoning

    Science.gov (United States)

    Divakaran, Ajay; Yu, Qian; Tamrakar, Amir; Sawhney, Harpreet Singh; Zhu, Jiejie; Javed, Omar; Liu, Jingen; Cheng, Hui; Eledath, Jayakrishnan

    2018-02-27

    A system for object detection and tracking includes technologies to, among other things, detect and track moving objects, such as pedestrians and/or vehicles, in a real-world environment, handle static and dynamic occlusions, and continue tracking moving objects across the fields of view of multiple different cameras.

  4. Subjective time pressure: general or domain specific?

    Science.gov (United States)

    Kleiner, Sibyl

    2014-09-01

    Chronic time pressure has been identified as a pervasive societal problem, exacerbated by high demands of the labor market and the home. Yet time pressure has not been disaggregated and examined separately across home and work contexts, leaving many unanswered questions regarding the sources and potentially stressful consequences of time pressure. Using data collected in the United States General Social Survey waves 2002 and 2004, this study disaggregates time pressure into the domains of home and work, and asks whether considering time pressures within distinct work and home contexts reveals distinct predictors or associations with stress. Findings show that both predictors and stress associations differ across work and home pressures, revealing both methodological and theoretical implications for the study of time pressure and work and family life more generally. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Atypical right hemisphere specialization for object representations in an adolescent with specific language impairment

    Directory of Open Access Journals (Sweden)

    Timothy T. Brown

    2014-02-01

    Full Text Available Individuals with a diagnosis of specific language impairment (SLI show abnormal spoken language occurring alongside normal nonverbal abilities. Behaviorally, people with SLI exhibit diverse profiles of impairment involving phonological, grammatical, syntactic, and semantic aspects of language. In this study, we used a multimodal neuroimaging technique called anatomically constrained magnetoencephalography (aMEG to measure the dynamic functional brain organization of an adolescent with SLI. Using single-subject statistical maps of cortical activity, we compared this patient to a sibling and to a cohort of typically developing subjects during the performance of tasks designed to evoke semantic representations of concrete objects. Localized, real-time patterns of brain activity within the language impaired patient showed marked differences from the typical functional organization, with significant engagement of right hemisphere heteromodal cortical regions generally homotopic to the left hemisphere areas that usually show the greatest activity for such tasks. Functional neuroanatomical differences were evident at early sensoriperceptual processing stages and continued through later cognitive stages, observed specifically at latencies typically associated with semantic encoding operations. Our findings show with real-time temporal specificity evidence for an atypical right hemisphere specialization for the representation of concrete entities, independent of verbal motor demands. More broadly, our results demonstrate the feasibility and potential utility of using aMEG to characterize individual patient differences in the dynamic functional organization of the brain.

  6. REAL-TIME OBJECT DETECTION IN PARALLEL THROUGH ATOMIC TRANSACTIONS

    Directory of Open Access Journals (Sweden)

    K Sivakumar

    2016-11-01

    Full Text Available Object detection and tracking is important operation involved in embedded systems like video surveillance, Traffic monitoring, campus security system, machine vision applications and other areas. Detecting and tracking multiple objects in a video or image is challenging problem in machine vision and computer vision based embedded systems. Implementation of such a object detection and tracking systems are done in sequential way of processing and also it was implemented using hardware synthesize tools like verilog HDL with FPGA, achieves considerably lesser performance in speed and it does support lesser atomic transactions. There are many object detection and tracking algorithm were proposed and implemented, among them background subtraction is one of them. This paper proposes a implementation of detecting and tracking multiple objects based on background subtraction algorithm using java and .NET and also discuss about the architecture concept for object detection through atomic transactional, modern hardware synthesizes language called Bluespec.

  7. Real-time objects development: Study and proposal for a parallel scheduling architecture

    International Nuclear Information System (INIS)

    Rioux, Laurent

    1997-01-01

    This thesis contributes to the programming and the execution control of real-time object oriented applications. Using real-time objects is very interesting for programming real- time applications, because this model can introduce the concurrence with the encapsulation properties, with modularity and reusability by taking into account the real-time constraints of the application. One essential quality of this approach is that it can directly specify the parallelism and the real-time constraints at the model level of the application. An annotation system of C++ has been defined to describe the real-time specifications in the model (or in the source code) of the application. It will supply to the execution support the different information it needs for the control. In this approach of multitasking, the control is distributed and encapsulated inside each real time object. Three complementary levels of control have been defined: the state level (defining the capability of an object to treat an operation), the concurrence level (assuring the coherence between the object attributes) and a scheduling control (allocating the processors resources to the object by taking real-time constraints into account). The proposed control architecture, named OROS, manages the attribute access of each object in an individual way, then it can parallel treatments which do not access at the same data. This architecture makes a dynamic control of an application that can take benefit from the parallelism of the new machines both for the execution parallelism and the control itself. This architecture uses only the simplest primitives of the industrial real-time operating systems which ensures its feasibility and portability. (author) [fr

  8. Do overarching mitigation objectives dominate transport-specific targets in the EU?

    OpenAIRE

    GHERSI , Frédéric; Mcdonnell , Simon; Sassi , Olivier

    2013-01-01

    International audience; This research investigates if the stringent 2020 and 2050 overarching CO2 mitigation objectives set out by the European Union dominate its 2010 to 2020 targets specific to the transportation arena, specifically its biofuel penetration objectives and gram CO2 per kilometre emission caps. Using a dynamic recursive general equilibrium model, IMACLIM-R, we demonstrate that these overarching targets do not dominate the interim transportation targets when the carbon policy t...

  9. A Real-Time Method to Estimate Speed of Object Based on Object Detection and Optical Flow Calculation

    Science.gov (United States)

    Liu, Kaizhan; Ye, Yunming; Li, Xutao; Li, Yan

    2018-04-01

    In recent years Convolutional Neural Network (CNN) has been widely used in computer vision field and makes great progress in lots of contents like object detection and classification. Even so, combining Convolutional Neural Network, which means making multiple CNN frameworks working synchronously and sharing their output information, could figure out useful message that each of them cannot provide singly. Here we introduce a method to real-time estimate speed of object by combining two CNN: YOLOv2 and FlowNet. In every frame, YOLOv2 provides object size; object location and object type while FlowNet providing the optical flow of whole image. On one hand, object size and object location help to select out the object part of optical flow image thus calculating out the average optical flow of every object. On the other hand, object type and object size help to figure out the relationship between optical flow and true speed by means of optics theory and priori knowledge. Therefore, with these two key information, speed of object can be estimated. This method manages to estimate multiple objects at real-time speed by only using a normal camera even in moving status, whose error is acceptable in most application fields like manless driving or robot vision.

  10. Objectivity

    CERN Document Server

    Daston, Lorraine

    2010-01-01

    Objectivity has a history, and it is full of surprises. In Objectivity, Lorraine Daston and Peter Galison chart the emergence of objectivity in the mid-nineteenth-century sciences--and show how the concept differs from its alternatives, truth-to-nature and trained judgment. This is a story of lofty epistemic ideals fused with workaday practices in the making of scientific images. From the eighteenth through the early twenty-first centuries, the images that reveal the deepest commitments of the empirical sciences--from anatomy to crystallography--are those featured in scientific atlases, the compendia that teach practitioners what is worth looking at and how to look at it. Galison and Daston use atlas images to uncover a hidden history of scientific objectivity and its rivals. Whether an atlas maker idealizes an image to capture the essentials in the name of truth-to-nature or refuses to erase even the most incidental detail in the name of objectivity or highlights patterns in the name of trained judgment is a...

  11. Advantages of Task-Specific Multi-Objective Optimisation in Evolutionary Robotics.

    Science.gov (United States)

    Trianni, Vito; López-Ibáñez, Manuel

    2015-01-01

    The application of multi-objective optimisation to evolutionary robotics is receiving increasing attention. A survey of the literature reveals the different possibilities it offers to improve the automatic design of efficient and adaptive robotic systems, and points to the successful demonstrations available for both task-specific and task-agnostic approaches (i.e., with or without reference to the specific design problem to be tackled). However, the advantages of multi-objective approaches over single-objective ones have not been clearly spelled out and experimentally demonstrated. This paper fills this gap for task-specific approaches: starting from well-known results in multi-objective optimisation, we discuss how to tackle commonly recognised problems in evolutionary robotics. In particular, we show that multi-objective optimisation (i) allows evolving a more varied set of behaviours by exploring multiple trade-offs of the objectives to optimise, (ii) supports the evolution of the desired behaviour through the introduction of objectives as proxies, (iii) avoids the premature convergence to local optima possibly introduced by multi-component fitness functions, and (iv) solves the bootstrap problem exploiting ancillary objectives to guide evolution in the early phases. We present an experimental demonstration of these benefits in three different case studies: maze navigation in a single robot domain, flocking in a swarm robotics context, and a strictly collaborative task in collective robotics.

  12. Advantages of Task-Specific Multi-Objective Optimisation in Evolutionary Robotics.

    Directory of Open Access Journals (Sweden)

    Vito Trianni

    Full Text Available The application of multi-objective optimisation to evolutionary robotics is receiving increasing attention. A survey of the literature reveals the different possibilities it offers to improve the automatic design of efficient and adaptive robotic systems, and points to the successful demonstrations available for both task-specific and task-agnostic approaches (i.e., with or without reference to the specific design problem to be tackled. However, the advantages of multi-objective approaches over single-objective ones have not been clearly spelled out and experimentally demonstrated. This paper fills this gap for task-specific approaches: starting from well-known results in multi-objective optimisation, we discuss how to tackle commonly recognised problems in evolutionary robotics. In particular, we show that multi-objective optimisation (i allows evolving a more varied set of behaviours by exploring multiple trade-offs of the objectives to optimise, (ii supports the evolution of the desired behaviour through the introduction of objectives as proxies, (iii avoids the premature convergence to local optima possibly introduced by multi-component fitness functions, and (iv solves the bootstrap problem exploiting ancillary objectives to guide evolution in the early phases. We present an experimental demonstration of these benefits in three different case studies: maze navigation in a single robot domain, flocking in a swarm robotics context, and a strictly collaborative task in collective robotics.

  13. Specification and Automated Verification of Real-Time Behaviour

    DEFF Research Database (Denmark)

    Kristensen, C.H.; Andersen, J.H.; Skou, A.

    1995-01-01

    In this paper we sketch a method for specification and automatic verification of real-time software properties.......In this paper we sketch a method for specification and automatic verification of real-time software properties....

  14. Specification and Automated Verification of Real-Time Behaviour

    DEFF Research Database (Denmark)

    Andersen, J.H.; Kristensen, C.H.; Skou, A.

    1996-01-01

    In this paper we sketch a method for specification and automatic verification of real-time software properties.......In this paper we sketch a method for specification and automatic verification of real-time software properties....

  15. Patterns of muscle activity underlying object-specific grasp by the macaque monkey.

    Science.gov (United States)

    Brochier, T; Spinks, R L; Umilta, M A; Lemon, R N

    2004-09-01

    During object grasp, a coordinated activation of distal muscles is required to shape the hand in relation to the physical properties of the object. Despite the fundamental importance of the grasping action, little is known of the muscular activation patterns that allow objects of different sizes and shapes to be grasped. In a study of two adult macaque monkeys, we investigated whether we could distinguish between EMG activation patterns associated with grasp of 12 differently shaped objects, chosen to evoke a wide range of grasping postures. Each object was mounted on a horizontal shuttle held by a weak spring (load force 1-2 N). Objects were located in separate sectors of a "carousel," and inter-trial rotation of the carousel allowed sequential presentation of the objects in pseudorandom order. EMG activity from 10 to 12 digit, hand, and arm muscles was recorded using chronically implanted electrodes. We show that the grasp of different objects was characterized by complex but distinctive patterns of EMG activation. Cluster analysis shows that these object-related EMG patterns were specific and consistent enough to identify the object unequivocally from the EMG recordings alone. EMG-based object identification required a minimum of six EMGs from simultaneously recorded muscles. EMG patterns were consistent across recording sessions in a given monkey but showed some differences between animals. These results identify the specific patterns of activity required to achieve distinct hand postures for grasping, and they open the way to our understanding of how these patterns are generated by the central motor network.

  16. Do overarching mitigation objectives dominate transport-specific targets in the EU?

    International Nuclear Information System (INIS)

    Ghersi, Frédéric; McDonnell, Simon; Sassi, Olivier

    2013-01-01

    This research investigates if the stringent 2020 and 2050 overarching CO 2 mitigation objectives set out by the European Union dominate its 2010 to 2020 targets specific to the transportation arena, specifically its biofuel penetration objectives and gram CO 2 per kilometre emission caps. Using a dynamic recursive general equilibrium model, IMACLIM-R, we demonstrate that these overarching targets do not dominate the interim transportation targets when the carbon policy triggering compliance with the mitigation objectives boils down to the theoretical least-cost option of uniform carbon pricing. Ground transportation is confirmed as quite insensitive to high carbon prices, even when such prices are applied over a long term. It is tempting to conclude that pursuing the mitigation objectives specific to transportation will impose unnecessary costs. However, because of the second best conditions prevailing in actual economies, and of the risk of lock-in in carbon intensive trajectories, we conclude with the urgent need for some ambitious transport-specific policy design research agenda. - Highlights: ► We review the European Union’s climate and transportation policy. ► We describe the IMACLIM-R model and how it represents transport. ► We develop an EU carbon pricing scenario that meets its aggregate CO 2 targets. ► This does not require meeting biofuel nor g/km 2010 to 2020 objectives. ► We conclude on the policy implications of this apparent inefficiency

  17. Design Specifications for Adaptive Real-Time Systems

    Science.gov (United States)

    1991-12-01

    TICfl \\ E CT E Design Specifications for JAN’\\ 1992 Adaptive Real - Time Systems fl Randall W. Lichota U, Alice H. Muntz - December 1991 \\ \\\\/ 0 / r...268-2056 Technical Report CMU/SEI-91-TR-20 ESD-91-TR-20 December 1991 Design Specifications for Adaptive Real - Time Systems Randall W. Lichota Hughes...Design Specifications for Adaptive Real - Time Systems Abstract: The design specification method described in this report treats a software

  18. Real-time detection of natural objects using AM-coded spectral matching imager

    Science.gov (United States)

    Kimachi, Akira

    2005-01-01

    This paper describes application of the amplitude-modulation (AM)-coded spectral matching imager (SMI) to real-time detection of natural objects such as human beings, animals, vegetables, or geological objects or phenomena, which are much more liable to change with time than artificial products while often exhibiting characteristic spectral functions associated with some specific activity states. The AM-SMI produces correlation between spectral functions of the object and a reference at each pixel of the correlation image sensor (CIS) in every frame, based on orthogonal amplitude modulation (AM) of each spectral channel and simultaneous demodulation of all channels on the CIS. This principle makes the SMI suitable to monitoring dynamic behavior of natural objects in real-time by looking at a particular spectral reflectance or transmittance function. A twelve-channel multispectral light source was developed with improved spatial uniformity of spectral irradiance compared to a previous one. Experimental results of spectral matching imaging of human skin and vegetable leaves are demonstrated, as well as a preliminary feasibility test of imaging a reflective object using a test color chart.

  19. Specific and Class Object Recognition for Service Robots through Autonomous and Interactive Methods

    Science.gov (United States)

    Mansur, Al; Kuno, Yoshinori

    Service robots need to be able to recognize and identify objects located within complex backgrounds. Since no single method may work in every situation, several methods need to be combined and robots have to select the appropriate one automatically. In this paper we propose a scheme to classify situations depending on the characteristics of the object of interest and user demand. We classify situations into four groups and employ different techniques for each. We use Scale-invariant feature transform (SIFT), Kernel Principal Components Analysis (KPCA) in conjunction with Support Vector Machine (SVM) using intensity, color, and Gabor features for five object categories. We show that the use of appropriate features is important for the use of KPCA and SVM based techniques on different kinds of objects. Through experiments we show that by using our categorization scheme a service robot can select an appropriate feature and method, and considerably improve its recognition performance. Yet, recognition is not perfect. Thus, we propose to combine the autonomous method with an interactive method that allows the robot to recognize the user request for a specific object and class when the robot fails to recognize the object. We also propose an interactive way to update the object model that is used to recognize an object upon failure in conjunction with the user's feedback.

  20. The USL NASA PC R and D project: General specifications of objectives

    Science.gov (United States)

    Dominick, Wayne D. (Editor)

    1984-01-01

    Given here are the general specifications of the objectives of the University of Southwestern Louisiana Data Base Management System (USL/DBMS) NASA PC R and D Project, a project initiated to address future R and D issues related to PC-based processing environments acquired pursuant to the NASA contract work; namely, the IBM PC/XT systems.

  1. The specifics of the Russian market of confectionery: subject-object certainty

    Directory of Open Access Journals (Sweden)

    Tsarenko Elena

    2012-12-01

    Full Text Available This article describes a study of the Russian confectionery market. Determining the specificity of the market in Russia, identified and examined the components of this market with the help of subject - object orientation. As well as the actuality of considering new approaches to promote sales of confectionery products.

  2. Quantifying the Time Course of Visual Object Processing Using ERPs: It's Time to Up the Game

    Science.gov (United States)

    Rousselet, Guillaume A.; Pernet, Cyril R.

    2011-01-01

    Hundreds of studies have investigated the early ERPs to faces and objects using scalp and intracranial recordings. The vast majority of these studies have used uncontrolled stimuli, inappropriate designs, peak measurements, poor figures, and poor inferential and descriptive group statistics. These problems, together with a tendency to discuss any effect p  condition B. Here we describe the main limitations of face and object ERP research and suggest alternative strategies to move forward. The problems plague intracranial and surface ERP studies, but also studies using more advanced techniques – e.g., source space analyses and measurements of network dynamics, as well as many behavioral, fMRI, TMS, and LFP studies. In essence, it is time to stop amassing binary results and start using single-trial analyses to build models of visual perception. PMID:21779262

  3. Configuration management issues and objectives for a real-time research flight test support facility

    Science.gov (United States)

    Yergensen, Stephen; Rhea, Donald C.

    1988-01-01

    Presented are some of the critical issues and objectives pertaining to configuration management for the NASA Western Aeronautical Test Range (WATR) of Ames Research Center. The primary mission of the WATR is to provide a capability for the conduct of aeronautical research flight test through real-time processing and display, tracking, and communications systems. In providing this capability, the WATR must maintain and enforce a configuration management plan which is independent of, but complimentary to, various research flight test project configuration management systems. A primary WATR objective is the continued development of generic research flight test project support capability, wherein the reliability of WATR support provided to all project users is a constant priority. Therefore, the processing of configuration change requests for specific research flight test project requirements must be evaluated within a perspective that maintains this primary objective.

  4. Early (N170) activation of face-specific cortex by face-like objects

    OpenAIRE

    Hadjikhani, Nouchine; Kveraga, Kestutis; Naik, Paulami; Ahlfors, Seppo P.

    2009-01-01

    The tendency to perceive faces in random patterns exhibiting configural properties of faces is an example of pareidolia. Perception of ‘real’ faces has been associated with a cortical response signal arising at about 170ms after stimulus onset; but what happens when non-face objects are perceived as faces? Using magnetoencephalography (MEG), we found that objects incidentally perceived as faces evoked an early (165ms) activation in the ventral fusiform cortex, at a time and location similar t...

  5. On the time required for identification of visual objects

    DEFF Research Database (Denmark)

    Petersen, Anders

    The starting point for this thesis is a review of Bundesen’s theory of visual attention. This theory has been widely accepted as an appropriate model for describing data from an important class of psychological experiments known as whole and partial report. Analysing data from this class of exper......The starting point for this thesis is a review of Bundesen’s theory of visual attention. This theory has been widely accepted as an appropriate model for describing data from an important class of psychological experiments known as whole and partial report. Analysing data from this class...... of experiments with the help of the theory of visual attention – have proven to be an effective approach to examine cognitive parameters that are essential for a broad range of different patient groups. The theory of visual attention relies on a psychometric function that describes the ability to identify......, with the dataset that we collected, to directly analyse how confusability develops as a certain letter is exposed for increasingly longer time. An important scientific question is what shapes the psychometric function. It is conceivable that the function reflects both limitations and structure of the physical...

  6. Will Instructors Save Time Using a Specifications Grading System?

    Directory of Open Access Journals (Sweden)

    Sarah Grace Prescott

    2015-08-01

    Full Text Available Review of: Specifications Grading: Restoring Rigor, Motivating Students, and Saving Faculty Time; Linda Nilson and Claudia J. Stranny; (2014. Stylus Publishing, Sterling, VA. 184 pages.

  7. Guidance and methods for satisfying low specific activity material and surface contaminated object regulatory requirements

    International Nuclear Information System (INIS)

    Pope, R.B.; Shappert, L.B.; Michelhaugh, R.D.; Boyle, R.W.; Easton, E.P.; Coodk, J.R.

    1998-01-01

    The U.S. Department of Transportation (DOT) and the U.S. Nuclear Regulatory Commission (NRC) have prepared a comprehensive set of draft guidance for shippers and inspectors to use when applying the newly imposed regulatory requirements for low specific activity (LSA) material and surface contaminated objects (SCOs). These requirements represent significant departures in some areas from the manner in which these materials and objects were regulated by the earlier versions of the regulations. The proper interpretation and application of the regulatory criteria can require a fairly complex set of decisions be made. To assist those trying these regulatory requirements, a detailed set of logic-flow diagrams representing decisions related to multiple factors were prepared and included in the draft report for comment on Categorizing and Transporting Low Specific Activity Materials and Surface Contaminated Objects, (DOT/NRC, 1997). These logic-flow diagrams, as developed, are specific to the U.S. regulations, but were readily adaptable to the IAEA regulations. The diagrams have been modified accordingly and tied directly to specific paragraphs in IAEA Safety Series No. 6. This paper provides the logic-flow diagrams adapted in the IAEA regulations, and demonstrated how these diagrams can be used to assist consignors and inspectors in assessing compliance of shipments with the LSA material and SCO regulatory requirements. (authors)

  8. The USL NASA PC R and D project: Detailed specifications of objects

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Chum, Frank Y.; Hall, Philip P.; Moreau, Dennis R.; Triantafyllopoulos, Spiros

    1984-01-01

    The specifications for a number of projects which are to be implemented within the University of Southwestern Louisiana NASA PC R and D Project are discussed. The goals and objectives of the PC development project and the interrelationships of the various components are discussed. Six projects are described. They are a NASA/RECON simulator, a user interface to multiple remote information systems, evaluation of various personal computer systems, statistical analysis software development, interactive presentation system development, and the development of a distributed processing environment. The relationships of these projects to one another and to the goals and objectives of the overall project are discussed.

  9. Early (M170) activation of face-specific cortex by face-like objects.

    Science.gov (United States)

    Hadjikhani, Nouchine; Kveraga, Kestutis; Naik, Paulami; Ahlfors, Seppo P

    2009-03-04

    The tendency to perceive faces in random patterns exhibiting configural properties of faces is an example of pareidolia. Perception of 'real' faces has been associated with a cortical response signal arising at approximately 170 ms after stimulus onset, but what happens when nonface objects are perceived as faces? Using magnetoencephalography, we found that objects incidentally perceived as faces evoked an early (165 ms) activation in the ventral fusiform cortex, at a time and location similar to that evoked by faces, whereas common objects did not evoke such activation. An earlier peak at 130 ms was also seen for images of real faces only. Our findings suggest that face perception evoked by face-like objects is a relatively early process, and not a late reinterpretation cognitive phenomenon.

  10. Early (N170) activation of face-specific cortex by face-like objects

    Science.gov (United States)

    Hadjikhani, Nouchine; Kveraga, Kestutis; Naik, Paulami; Ahlfors, Seppo P.

    2009-01-01

    The tendency to perceive faces in random patterns exhibiting configural properties of faces is an example of pareidolia. Perception of ‘real’ faces has been associated with a cortical response signal arising at about 170ms after stimulus onset; but what happens when non-face objects are perceived as faces? Using magnetoencephalography (MEG), we found that objects incidentally perceived as faces evoked an early (165ms) activation in the ventral fusiform cortex, at a time and location similar to that evoked by faces, whereas common objects did not evoke such activation. An earlier peak at 130 ms was also seen for images of real faces only. Our findings suggest that face perception evoked by face-like objects is a relatively early process, and not a late re-interpretation cognitive phenomenon. PMID:19218867

  11. Passive UHF RFID Tags with Specific Printed Antennas for Dielectric and Metallic Objects Applications

    Directory of Open Access Journals (Sweden)

    K. Siakavara

    2017-09-01

    Full Text Available Design process and respective results for the synthesis of specific Radiofrequency Identification(RFID tag antennas, suitable for dielectric and metallic objects, are presented. The antennas were designed for the UHF(865MHz-869MHz band and their basic configuration is that of the printed spiral type. Six modification steps to the classical spiral layout are proposed and it was proved that they can lead to tags with high readability and reading distances up to 10m when designed for dielectric object and up to 7m in the case of metallic objects. The results of the measurements of the fabricated tags are explained via theoretical evaluations which take into account reflection phenomena, that are present in a real environment at which the tags are used.

  12. Object instance recognition using motion cues and instance specific appearance models

    Science.gov (United States)

    Schumann, Arne

    2014-03-01

    In this paper we present an object instance retrieval approach. The baseline approach consists of a pool of image features which are computed on the bounding boxes of a query object track and compared to a database of tracks in order to find additional appearances of the same object instance. We improve over this simple baseline approach in multiple ways: 1) we include motion cues to achieve improved robustness to viewpoint and rotation changes, 2) we include operator feedback to iteratively re-rank the resulting retrieval lists and 3) we use operator feedback and location constraints to train classifiers and learn an instance specific appearance model. We use these classifiers to further improve the retrieval results. The approach is evaluated on two popular public datasets for two different applications. We evaluate person re-identification on the CAVIAR shopping mall surveillance dataset and vehicle instance recognition on the VIVID aerial dataset and achieve significant improvements over our baseline results.

  13. Multiple containment for LSA [low specific activity] and SCO [surface contaminated objects] wastes

    International Nuclear Information System (INIS)

    Burgess, M.H.

    1993-09-01

    Radioactive wastes are generally transported in the form of Low Specific Activity (LSA) materials or Surface Contaminated Objects (SCO). This report proposes that a method of acknowledging the beneficial effects of multiple containment for such wastes should be written into the 1996 Edition of the IAEA Transport Regulations. Experience used to assess risks from on-site movements of radioactive material in the UK can be applied to develop safety arguments justifying the alleviation of off-site transport risks. (UK)

  14. Comparison of Objectively Measured and Self-reported Time Spent Sitting

    DEFF Research Database (Denmark)

    Lagersted-Olsen, Julie; Korshøj, M; Skotte, J

    2014-01-01

    Until recently, methods for objective quantification of sitting time have been lacking. The aim of this study was to validate self-reported measures against objectively measured total sitting time and longest continuous time with uninterrupted sitting during working hours, leisure time on workday...... a retrospective 7-day questionnaire. A generalized linear model showed the difference between the methods. No significant correlations were found between objective and self-reported sitting time (r...

  15. Correlates of objectively measured sedentary time and self-reported screen time in Canadian children.

    Science.gov (United States)

    LeBlanc, Allana G; Broyles, Stephanie T; Chaput, Jean-Philippe; Leduc, Geneviève; Boyer, Charles; Borghese, Michael M; Tremblay, Mark S

    2015-03-18

    Demographic, family, and home characteristics play an important role in determining childhood sedentary behaviour. The objective of this paper was to identify correlates of total sedentary time (SED) and correlates of self-reported screen time (ST) in Canadian children. Child- and parent-reported household, socio-demographic, behavioural, and diet related data were collected; directly measured anthropometric and accelerometer data were also collected for each child. Participants with complete demographic, anthropometric, and either SED (n=524, 41% boys) or ST (n=567, 42% boys) data from the Canadian site of the International Study of Childhood Obesity Lifestyle and the Environment (ISCOLE) were included in analysis. Sixteen potential correlates of SED and ST were examined using multilevel general linear models, adjusting for sex, ethnicity, number of siblings, and socio-economic status. All explanatory variables moderately associated (peducation, and unhealthy eating pattern score and negatively associated with healthy eating pattern score, and weekend breakfast consumption. Few common correlates existed between boys and girls. Several factors were identified as correlates of SED and/or of ST in Canadian children; however, few correlates were common for both SED and ST, and for both boys and girls. This suggests that a single strategy to reduce SED and ST is unlikely to be effective. Future work should examine a variety of other, non-screen based sedentary behaviours and their potential correlates in the hopes of creating tailored public health messages to reduce SED and ST in both boys, and girls.

  16. Compiling graphical real-time specifications into silicon

    DEFF Research Database (Denmark)

    Fränzle, Martin; Lüth, Karsten

    1998-01-01

    The basic algorithms underlying an automatic hardware synthesis environment using fully formal graphical requirements specifications as source language are outlined. The source language is real-time symbolic timing diagrams [FeyerabendJosko97], which are a metric-time temporal logic such that hard...

  17. Temporal Specification and Verification of Real-Time Systems.

    Science.gov (United States)

    1991-08-30

    of concrete real - time systems can be modeled adequately. Specification: We present two conservative extensions of temporal logic that allow for the...logic. We present both model-checking algorithms for the automatic verification of finite-state real - time systems and proof methods for the deductive verification of real - time systems .

  18. Predictive coding of visual object position ahead of moving objects revealed by time-resolved EEG decoding.

    Science.gov (United States)

    Hogendoorn, Hinze; Burkitt, Anthony N

    2018-05-01

    Due to the delays inherent in neuronal transmission, our awareness of sensory events necessarily lags behind the occurrence of those events in the world. If the visual system did not compensate for these delays, we would consistently mislocalize moving objects behind their actual position. Anticipatory mechanisms that might compensate for these delays have been reported in animals, and such mechanisms have also been hypothesized to underlie perceptual effects in humans such as the Flash-Lag Effect. However, to date no direct physiological evidence for anticipatory mechanisms has been found in humans. Here, we apply multivariate pattern classification to time-resolved EEG data to investigate anticipatory coding of object position in humans. By comparing the time-course of neural position representation for objects in both random and predictable apparent motion, we isolated anticipatory mechanisms that could compensate for neural delays when motion trajectories were predictable. As well as revealing an early neural position representation (lag 80-90 ms) that was unaffected by the predictability of the object's trajectory, we demonstrate a second neural position representation at 140-150 ms that was distinct from the first, and that was pre-activated ahead of the moving object when it moved on a predictable trajectory. The latency advantage for predictable motion was approximately 16 ± 2 ms. To our knowledge, this provides the first direct experimental neurophysiological evidence of anticipatory coding in human vision, revealing the time-course of predictive mechanisms without using a spatial proxy for time. The results are numerically consistent with earlier animal work, and suggest that current models of spatial predictive coding in visual cortex can be effectively extended into the temporal domain. Copyright © 2018 Elsevier Inc. All rights reserved.

  19. Site-Specific Analyses for Demonstrating Compliance with 10 CFR 61 Performance Objectives - 12179

    Energy Technology Data Exchange (ETDEWEB)

    Grossman, C.J.; Esh, D.W.; Yadav, P.; Carrera, A.G. [U.S. Nuclear Regulatory Commission, 11545 Rockville Pike, Rockville, MD 20852 (United States)

    2012-07-01

    The U.S. Nuclear Regulatory Commission (NRC) is proposing to amend its regulations at 10 CFR Part 61 to require low-level radioactive waste disposal facilities to conduct site-specific analyses to demonstrate compliance with the performance objectives in Subpart C. The amendments would require licensees to conduct site-specific analyses for protection of the public and inadvertent intruders as well as analyses for long-lived waste. The amendments would ensure protection of public health and safety, while providing flexibility to demonstrate compliance with the performance objectives, for current and potential future waste streams. NRC staff intends to submit proposed rule language and associated regulatory basis to the Commission for its approval in early 2012. The NRC staff also intends to develop associated guidance to accompany any proposed amendments. The guidance is intended to supplement existing low-level radioactive waste guidance on issues pertinent to conducting site-specific analyses to demonstrate compliance with the performance objectives. The guidance will facilitate implementation of the proposed amendments by licensees and assist competent regulatory authorities in reviewing the site-specific analyses. Specifically, the guidance provides staff recommendations on general considerations for the site-specific analyses, modeling issues for assessments to demonstrate compliance with the performance objectives including the performance assessment, intruder assessment, stability assessment, and analyses for long-lived waste. This paper describes the technical basis for changes to the rule language and the proposed guidance associated with implementation of the rule language. The NRC staff, per Commission direction, intends to propose amendments to 10 CFR Part 61 to require licensees to conduct site-specific analyses to demonstrate compliance with performance objectives for the protection of public health and the environment. The amendments would require a

  20. Fragile visual short-term memory is an object-based and location-specific store.

    Science.gov (United States)

    Pinto, Yaïr; Sligte, Ilja G; Shapiro, Kimron L; Lamme, Victor A F

    2013-08-01

    Fragile visual short-term memory (FM) is a recently discovered form of visual short-term memory. Evidence suggests that it provides rich and high-capacity storage, like iconic memory, yet it exists, without interference, almost as long as visual working memory. In the present study, we sought to unveil the functional underpinnings of this memory storage. We found that FM is only completely erased when the new visual scene appears at the same location and consists of the same objects as the to-be-recalled information. This result has two important implications: First, it shows that FM is an object- and location-specific store, and second, it suggests that FM might be used in everyday life when the presentation of visual information is appropriately designed.

  1. Holographic cinematography of time-varying reflecting and time-varying phase objects using a Nd:YAG laser

    Science.gov (United States)

    Decker, A. J.

    1982-01-01

    The use of a Nd:YAG laser to record holographic motion pictures of time-varying reflecting objects and time-varying phase objects is discussed. Sample frames from both types of holographic motion pictures are presented. The holographic system discussed is intended for three-dimensional flow visualization of the time-varying flows that occur in jet-engine components.

  2. Automated real time constant-specificity surveillance for disease outbreaks

    Directory of Open Access Journals (Sweden)

    Brownstein John S

    2007-06-01

    Full Text Available Abstract Background For real time surveillance, detection of abnormal disease patterns is based on a difference between patterns observed, and those predicted by models of historical data. The usefulness of outbreak detection strategies depends on their specificity; the false alarm rate affects the interpretation of alarms. Results We evaluate the specificity of five traditional models: autoregressive, Serfling, trimmed seasonal, wavelet-based, and generalized linear. We apply each to 12 years of emergency department visits for respiratory infection syndromes at a pediatric hospital, finding that the specificity of the five models was almost always a non-constant function of the day of the week, month, and year of the study (p Conclusion Modeling the variance of visit patterns enables real-time detection with known, constant specificity at all times. With constant specificity, public health practitioners can better interpret the alarms and better evaluate the cost-effectiveness of surveillance systems.

  3. Specification and Compilation of Real-Time Stream Processing Applications

    NARCIS (Netherlands)

    Geuns, S.J.

    2015-01-01

    This thesis is concerned with the specification, compilation and corresponding temporal analysis of real-time stream processing applications that are executed on embedded multiprocessor systems. An example of such applications are software defined radio applications. These applications typically

  4. Automated real time constant-specificity surveillance for disease outbreaks.

    Science.gov (United States)

    Wieland, Shannon C; Brownstein, John S; Berger, Bonnie; Mandl, Kenneth D

    2007-06-13

    For real time surveillance, detection of abnormal disease patterns is based on a difference between patterns observed, and those predicted by models of historical data. The usefulness of outbreak detection strategies depends on their specificity; the false alarm rate affects the interpretation of alarms. We evaluate the specificity of five traditional models: autoregressive, Serfling, trimmed seasonal, wavelet-based, and generalized linear. We apply each to 12 years of emergency department visits for respiratory infection syndromes at a pediatric hospital, finding that the specificity of the five models was almost always a non-constant function of the day of the week, month, and year of the study (p accounting for not only the expected number of visits, but also the variance of the number of visits. The expectation-variance model achieves constant specificity on all three time scales, as well as earlier detection and improved sensitivity compared to traditional methods in most circumstances. Modeling the variance of visit patterns enables real-time detection with known, constant specificity at all times. With constant specificity, public health practitioners can better interpret the alarms and better evaluate the cost-effectiveness of surveillance systems.

  5. Demographic correlates of screen time and objectively measured sedentary time and physical activity among toddlers: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Valerie Carson

    2017-02-01

    Full Text Available Abstract Background Determining the most important demographic correlates of sedentary behavior and physical activity will help identify the groups of children that are most in need of intervention. Little is known in regards to the demographic correlates of sedentary behavior and physical activity in toddlers (aged 12–35 months, where long-term behavioral patterns may initially be formed. Therefore, the objective of this study was to examine the associations between demographic correlates and specific types of sedentary behavior and physical activity in this age group. Methods Findings are based on 149 toddlers (19.0 ± 1.9 months and their parents (33.7 ± 4.7 years recruited from immunization clinics in Edmonton, Canada as part of the Parents’ Role in Establishing healthy Physical activity and Sedentary behavior habits (PREPS project. Toddlers’ and parental demographic characteristics and toddlers’ television viewing, video/computer games, and overall screen time were measured via the PREPS parental questionnaire. Toddlers’ objectively measured sedentary time and physical activity (light, moderate to vigorous, and total were accelerometer-derived using Actigraph wGT3X-BT monitors. Simple and multiple linear regression models were conducted to examine associations. Results In the multiple linear regression models, toddlers’ age, toddlers’ sex (female versus male, toddlers’ race/ethnicity (other versus European-Canadian/Caucasian, and household income ($50,001 to $100,000 versus > $100,000 were significantly positively associated, and main type of child care (child care center versus parental care was significantly negatively associated with screen time. Similar findings were observed with television viewing, except null associations were observed for toddlers’ sex. Toddlers’ race/ethnicity (other versus European-Canadian/Caucasian was significantly positively associated and main type of child care (child care

  6. Forebrain-Specific Loss of BMPRII in Mice Reduces Anxiety and Increases Object Exploration.

    Science.gov (United States)

    McBrayer, Zofeyah L; Dimova, Jiva; Pisansky, Marc T; Sun, Mu; Beppu, Hideyuki; Gewirtz, Jonathan C; O'Connor, Michael B

    2015-01-01

    To investigate the role of Bone Morphogenic Protein Receptor Type II (BMPRII) in learning, memory, and exploratory behavior in mice, a tissue-specific knockout of BMPRII in the post-natal hippocampus and forebrain was generated. We found that BMPRII mutant mice had normal spatial learning and memory in the Morris water maze, but showed significantly reduced swimming speeds with increased floating behavior. Further analysis using the Porsolt Swim Test to investigate behavioral despair did not reveal any differences in immobility between mutants and controls. In the Elevated Plus Maze, BMPRII mutants and Smad4 mutants showed reduced anxiety, while in exploratory tests, BMPRII mutants showed more interest in object exploration. These results suggest that loss of BMPRII in the mouse hippocampus and forebrain does not disrupt spatial learning and memory encoding, but instead impacts exploratory and anxiety-related behaviors.

  7. Forebrain-Specific Loss of BMPRII in Mice Reduces Anxiety and Increases Object Exploration.

    Directory of Open Access Journals (Sweden)

    Zofeyah L McBrayer

    Full Text Available To investigate the role of Bone Morphogenic Protein Receptor Type II (BMPRII in learning, memory, and exploratory behavior in mice, a tissue-specific knockout of BMPRII in the post-natal hippocampus and forebrain was generated. We found that BMPRII mutant mice had normal spatial learning and memory in the Morris water maze, but showed significantly reduced swimming speeds with increased floating behavior. Further analysis using the Porsolt Swim Test to investigate behavioral despair did not reveal any differences in immobility between mutants and controls. In the Elevated Plus Maze, BMPRII mutants and Smad4 mutants showed reduced anxiety, while in exploratory tests, BMPRII mutants showed more interest in object exploration. These results suggest that loss of BMPRII in the mouse hippocampus and forebrain does not disrupt spatial learning and memory encoding, but instead impacts exploratory and anxiety-related behaviors.

  8. Category-specific responses to faces and objects in primate auditory cortex

    Directory of Open Access Journals (Sweden)

    Kari L Hoffman

    2008-03-01

    Full Text Available Auditory and visual signals often occur together, and the two sensory channels are known to infl uence each other to facilitate perception. The neural basis of this integration is not well understood, although other forms of multisensory infl uences have been shown to occur at surprisingly early stages of processing in cortex. Primary visual cortex neurons can show frequency-tuning to auditory stimuli, and auditory cortex responds selectively to certain somatosensory stimuli, supporting the possibility that complex visual signals may modulate early stages of auditory processing. To elucidate which auditory regions, if any, are responsive to complex visual stimuli, we recorded from auditory cortex and the superior temporal sulcus while presenting visual stimuli consisting of various objects, neutral faces, and facial expressions generated during vocalization. Both objects and conspecifi c faces elicited robust fi eld potential responses in auditory cortex sites, but the responses varied by category: both neutral and vocalizing faces had a highly consistent negative component (N100 followed by a broader positive component (P180 whereas object responses were more variable in time and shape, but could be discriminated consistently from the responses to faces. The face response did not vary within the face category, i.e., for expressive vs. neutral face stimuli. The presence of responses for both objects and neutral faces suggests that auditory cortex receives highly informative visual input that is not restricted to those stimuli associated with auditory components. These results reveal selectivity for complex visual stimuli in a brain region conventionally described as non-visual unisensory cortex.

  9. Perceived and objectively measured physical activity and sedentary time among South Asian women in the UK.

    Science.gov (United States)

    Curry, Whitney Babakus; Duda, Joan L; Thompson, Janice L

    2015-03-16

    Limited self-report data suggest that South Asian (SA) women fail to meet physical activity (PA) recommendations. Recent research using objective measures reveals SA women living in the UK have higher PA levels than previously reported, and a pattern of under-reporting PA and sedentary time (ST). There is limited research on SA women's understanding and experiences of PA/ST, and the cultural contexts and conditions within which they occur. Therefore the aims of this mixed-methods study were to compare perceived PA and ST to objectively measured data and explore PA- and ST-specific contexts, experiences, and sources of PA and ST amongst SA women in the UK. 24 women were purposively sampled to participate in a semi-structured interview from a larger study of 140 women who wore an accelerometer for 7 days. Demographic and anthropometric data were also collected. Notable qualitative themes on contextualisation were of adequate PA as "keeping busy" or "being healthy", and of ST as "lazy" or "resting in old age". Few participants reported being sedentary, and most believed they were sufficiently physically active. Objectively measured PA/ST indicated that 66% women were less active than perceived (with regard to duration and intensity), with none able to estimate duration of ST. Findings suggest that overall, SA women have contextualisations of PA/ST that may not coincide with those of researchers, health professionals and policy makers, and lack awareness of the intensity of PA in which they engage and the health risks of high levels of ST. These findings highlight the need for objective measures of PA and ST in this population combined with in-depth qualitative assessments to provide more accurate assessments of these behaviours. This information can subsequently be used to develop health promotion messages and interventions focusing on increasing duration and/or intensity levels of daily activities (e.g., walking, housework) and reducing ST in this population.

  10. Development and investigation of aggregate models for nuclear objects with time shifts

    International Nuclear Information System (INIS)

    Gharakhanlou, J.; Kazachkov, I.V.

    2012-01-01

    The development and investigation of aggregate models for nuclear objects with shift arguments are discussed.The nonlinear differential equations of the model are described and the Cauchy problem is stated. The specific feature of the mathematical model for potentially hazardous nuclear objects are analyzed and computer simulation is presented

  11. The active blind spot camera: hard real-time recognition of moving objects from a moving camera

    OpenAIRE

    Van Beeck, Kristof; Goedemé, Toon; Tuytelaars, Tinne

    2014-01-01

    This PhD research focuses on visual object recognition under specific demanding conditions. The object to be recognized as well as the camera move, and the time available for the recognition task is extremely short. This generic problem is applied here on a specific problem: the active blind spot camera. Statistics show a large number of accidents with trucks are related to the so-called blind spot, the area around the vehicle in which vulnerable road users are hard to perceive by the truck d...

  12. Improving a real-time object detector with compact temporal information

    DEFF Research Database (Denmark)

    Ahrnbom, Martin; Jensen, Morten Bornø; Åström, Kalle

    2017-01-01

    Neural networks designed for real-time object detection have recently improved significantly, but in practice, look- ing at only a single RGB image at the time may not be ideal. For example, when detecting objects in videos, a foreground detection algorithm can be used to obtain compact temporal......, a problem this approach is well suited for. The ac- curacy was found to improve significantly (up to 66%), with a roughly 40% increase in computational time....

  13. Modeling of requirement specification for safety critical real time computer system using formal mathematical specifications

    International Nuclear Information System (INIS)

    Sankar, Bindu; Sasidhar Rao, B.; Ilango Sambasivam, S.; Swaminathan, P.

    2002-01-01

    Full text: Real time computer systems are increasingly used for safety critical supervision and control of nuclear reactors. Typical application areas are supervision of reactor core against coolant flow blockage, supervision of clad hot spot, supervision of undesirable power excursion, power control and control logic for fuel handling systems. The most frequent cause of fault in safety critical real time computer system is traced to fuzziness in requirement specification. To ensure the specified safety, it is necessary to model the requirement specification of safety critical real time computer systems using formal mathematical methods. Modeling eliminates the fuzziness in the requirement specification and also helps to prepare the verification and validation schemes. Test data can be easily designed from the model of the requirement specification. Z and B are the popular languages used for modeling the requirement specification. A typical safety critical real time computer system for supervising the reactor core of prototype fast breeder reactor (PFBR) against flow blockage is taken as case study. Modeling techniques and the actual model are explained in detail. The advantages of modeling for ensuring the safety are summarized

  14. Specification and Test of Real-Time Systems

    DEFF Research Database (Denmark)

    Nielsen, Brian

    of the system, and a set of constraint patterns which describes and enforces the timing and synchronization constraints among components. We propose new techniques for automated black box conformance testing of real-time systems against densely timed speci cations. A test generator tool examines a specification......Distributed real-time computer based systems are very complex and intrinsically difficult to specify and implement correctly; in part this is caused by the overwhelming number of possible interactions between system components, but especially by a lack of adequate methods and tools to deal...... of the desired system behavior and generates the necessary test cases. A main problem is to construct a reasonably small test suite that can be executed within allotted resources, while having a high likelihood of detecting unknown errors. Our goal has been to treat the time dimension of this problem thoroughly...

  15. Environmental Impact Specification for Direct Space Weathering of Kuiper Belt and Oort Cloud Objects

    Science.gov (United States)

    Cooper, John F.

    2010-01-01

    The Direct Space Weathering Project of NASA's Outer Planets Research Program addresses specification of the plasma and energetic particle environments for irradiation and surface chemical processing of icy bodies in the outer solar system and the local interstellar medium. Knowledge of the radiation environments is being expanded by ongoing penetration of the twin Voyager spacecraft into the heliosheath boundary region of the outer heliosphere and expected emergence within the next decade into the very local interstellar medium. The Voyager measurements are being supplemented by remote sensing from Earth orbit of energetic neutral atom emission from this boundary region by NASA's Interstellar Boundary Explorer (IBEX). Although the Voyagers long ago passed the region of the Classical Kuiper Belt, the New Horizons spacecraft will encounter Pluto in 2015 and thereafter explore one or more KBOs, meanwhile providing updated measurements of the heliospheric radiation environment in this region. Modeling of ion transport within the heliosphere allows specification of time-integrated irradiation effects while the combination of Voyager and IBEX data supports projection of the in-situ measurements into interstellar space beyond the heliosheath. Transformation of model ion flux distributions into surface sputtering and volume ionization profiles provides a multi-layer perspective for space weathering impact on the affected icy bodies and may account for some aspects of color and compositional diversity. Other important related factors may include surface erosion and gardening by meteoritic impacts and surface renewal by cryovolcanism. Chemical products of space weathering may contribute to energy resources for the latter.

  16. The time course of activation of object shape and shape+colour representations during memory retrieval.

    Directory of Open Access Journals (Sweden)

    Toby J Lloyd-Jones

    Full Text Available Little is known about the timing of activating memory for objects and their associated perceptual properties, such as colour, and yet this is important for theories of human cognition. We investigated the time course associated with early cognitive processes related to the activation of object shape and object shape+colour representations respectively, during memory retrieval as assessed by repetition priming in an event-related potential (ERP study. The main findings were as follows: (1 we identified a unique early modulation of mean ERP amplitude during the N1 that was associated with the activation of object shape independently of colour; (2 we also found a subsequent early P2 modulation of mean amplitude over the same electrode clusters associated with the activation of object shape+colour representations; (3 these findings were apparent across both familiar (i.e., correctly coloured - yellow banana and novel (i.e., incorrectly coloured - blue strawberry objects; and (4 neither of the modulations of mean ERP amplitude were evident during the P3. Together the findings delineate the timing of object shape and colour memory systems and support the notion that perceptual representations of object shape mediate the retrieval of temporary shape+colour representations for familiar and novel objects.

  17. The time course of activation of object shape and shape+colour representations during memory retrieval.

    Science.gov (United States)

    Lloyd-Jones, Toby J; Roberts, Mark V; Leek, E Charles; Fouquet, Nathalie C; Truchanowicz, Ewa G

    2012-01-01

    Little is known about the timing of activating memory for objects and their associated perceptual properties, such as colour, and yet this is important for theories of human cognition. We investigated the time course associated with early cognitive processes related to the activation of object shape and object shape+colour representations respectively, during memory retrieval as assessed by repetition priming in an event-related potential (ERP) study. The main findings were as follows: (1) we identified a unique early modulation of mean ERP amplitude during the N1 that was associated with the activation of object shape independently of colour; (2) we also found a subsequent early P2 modulation of mean amplitude over the same electrode clusters associated with the activation of object shape+colour representations; (3) these findings were apparent across both familiar (i.e., correctly coloured - yellow banana) and novel (i.e., incorrectly coloured - blue strawberry) objects; and (4) neither of the modulations of mean ERP amplitude were evident during the P3. Together the findings delineate the timing of object shape and colour memory systems and support the notion that perceptual representations of object shape mediate the retrieval of temporary shape+colour representations for familiar and novel objects.

  18. Online decoding of object-based attention using real-time fMRI

    NARCIS (Netherlands)

    Niazi, Adnan M.; van den Broek, Philip L.C.; Klanke, Stefan; Barth, Markus; Poel, Mannes; Desain, Peter; van Gerven, Marcel A.J.

    Visual attention is used to selectively filter relevant information depending on current task demands and goals. Visual attention is called object-based attention when it is directed to coherent forms or objects in the visual field. This study used real-time functional magnetic resonance imaging for

  19. Online decoding of object-based attention using real-time fMRI

    NARCIS (Netherlands)

    Niazi, A.M.; Broek, P.L.C. van den; Klanke, S.; Barth, M.; Poel, M.; Gerven, M.A.J. van

    2014-01-01

    Visual attention is used to selectively filter relevant information depending on current task demands and goals. Visual attention is called object-based attention when it is directed to coherent forms or objects in the visual field. This study used real-time functional magnetic resonance imaging for

  20. Real-time underwater object detection based on an electrically scanned high-resolution sonar

    DEFF Research Database (Denmark)

    Henriksen, Lars

    1994-01-01

    The paper describes an approach to real time detection and tracking of underwater objects, using image sequences from an electrically scanned high-resolution sonar. The use of a high resolution sonar provides a good estimate of the location of the objects, but strains the computers on board, beca...

  1. Do infant Japanese macaques ( Macaca fuscata) categorize objects without specific training?

    Science.gov (United States)

    Murai, Chizuko; Tomonaga, Masaki; Kamegai, Kimi; Terazawa, Naoko; Yamaguchi, Masami K

    2004-01-01

    In the present study, we examined whether infant Japanese macaques categorize objects without any training, using a similar technique also used with human infants (the paired-preference method). During the familiarization phase, subjects were presented twice with two pairs of different objects from one global-level category. During the test phase, they were presented twice with a pair consisting of a novel familiar-category object and a novel global-level category object. The subjects were tested with three global-level categories (animal, furniture, and vehicle). It was found that they showed significant novelty preferences as a whole, indicating that they processed similarities between familiarization objects and novel familiar-category objects. These results suggest that subjects responded distinctively to objects without training, indicating the possibility that infant macaques possess the capacity for categorization.

  2. Time-domain single-source integral equations for analyzing scattering from homogeneous penetrable objects

    KAUST Repository

    Valdé s, Felipe; Andriulli, Francesco P.; Bagci, Hakan; Michielssen, Eric

    2013-01-01

    Single-source time-domain electric-and magnetic-field integral equations for analyzing scattering from homogeneous penetrable objects are presented. Their temporal discretization is effected by using shifted piecewise polynomial temporal basis

  3. Semantic-Based Concurrency Control for Object-Oriented Database Systems Supporting Real-Time Applications

    National Research Council Canada - National Science Library

    Lee, Juhnyoung; Son, Sang H

    1994-01-01

    .... This paper investigates major issues in designing semantic-based concurrency control for object-oriented database systems supporting real-time applications, and it describes approaches to solving...

  4. Fixed, object-specific intensity compensation for cone beam optical CT radiation dosimetry

    Science.gov (United States)

    Dekker, Kurtis H.; Hazarika, Rubin; Silveira, Matheus A.; Jordan, Kevin J.

    2018-03-01

    Optical cone beam computed tomography (CT) scanning of radiochromic gel dosimeters, using a CCD camera and a low stray light convergent source, provides fast, truly 3D radiation dosimetry with high accuracy. However, a key limiting factor in radiochromic gel dosimetry at large (⩾10 cm diameter) volumes is the initial attenuation of the dosimeters. It is not unusual to observe a 5–10×  difference in signal intensity through the dosimeter center versus through the surrounding medium in pre-irradiation images. Thus, all dosimetric information in a typical experiment is measured within the lower 10%–20% of the camera sensor’s range, and re-use of gels is often not possible due to a lack of transmission. To counteract this, in this note we describe a simple method to create source compensators by printing on transparent films. This technique, which is easily implemented and inexpensive, is an optical analogue to the bowtie filter in x-ray CT. We present transmission images and solution phantom reconstructions to demonstrate that (1) placing compensators beyond the focal zone of the imaging lens prevents high spatial frequency features of the printed films from generating reconstruction artifacts, and (2) object-specific compensation considerably reduces the range of intensities measured in projection images. This will improve the measurable dose range in optical CT dosimetry, and will enable imaging of larger gel volumes (∼15 cm diameter). Additionally, it should enable re-use of dosimeters by printing a new compensator for a second experiment.

  5. Real time object localization based on histogram of s-RGB

    Science.gov (United States)

    Mudjirahardjo, Panca; Suyono, Hadi; Setyawan, Raden Arief

    2017-09-01

    Object localization is the first task in pattern detection and recognition. This task is very important due to it reduces the searching time to the interest object. In this paper we introduce our novel method of object localization based on color feature. Our novel method is a histogram of s-RGB. This histogram is used in the training phase to determine the color dominant in the initial Region of Interest (ROI). Then this information is used to label the interest object. To reduce noise and localize the interest object, we apply the row and column density function of pixels. The comparison result with some processes, our system gives a best result and takes a short computation time of 26.56 ms, in the video rate of 15 frames per second (fps).

  6. Collaborative real-time scheduling of multiple PTZ cameras for multiple object tracking in video surveillance

    Science.gov (United States)

    Liu, Yu-Che; Huang, Chung-Lin

    2013-03-01

    This paper proposes a multi-PTZ-camera control mechanism to acquire close-up imagery of human objects in a surveillance system. The control algorithm is based on the output of multi-camera, multi-target tracking. Three main concerns of the algorithm are (1) the imagery of human object's face for biometric purposes, (2) the optimal video quality of the human objects, and (3) minimum hand-off time. Here, we define an objective function based on the expected capture conditions such as the camera-subject distance, pan tile angles of capture, face visibility and others. Such objective function serves to effectively balance the number of captures per subject and quality of captures. In the experiments, we demonstrate the performance of the system which operates in real-time under real world conditions on three PTZ cameras.

  7. Perceived and Objectively Measured Physical Activity and Sedentary Time among South Asian Women in the UK

    Directory of Open Access Journals (Sweden)

    Whitney Babakus Curry

    2015-03-01

    Full Text Available Introduction: Limited self-report data suggest that South Asian (SA women fail to meet physical activity (PA recommendations. Recent research using objective measures reveals SA women living in the UK have higher PA levels than previously reported, and a pattern of under-reporting PA and sedentary time (ST. There is limited research on SA women’s understanding and experiences of PA/ST, and the cultural contexts and conditions within which they occur. Therefore the aims of this mixed-methods study were to compare perceived PA and ST to objectively measured data and explore PA- and ST-specific contexts, experiences, and sources of PA and ST amongst SA women in the UK. Methods: 24 women were purposively sampled to participate in a semi-structured interview from a larger study of 140 women who wore an accelerometer for 7 days. Demographic and anthropometric data were also collected. Results: Notable qualitative themes on contextualisation were of adequate PA as “keeping busy” or “being healthy”, and of ST as “lazy” or “resting in old age”. Few participants reported being sedentary, and most believed they were sufficiently physically active. Objectively measured PA/ST indicated that 66% women were less active than perceived (with regard to duration and intensity, with none able to estimate duration of ST. Discussion: Findings suggest that overall, SA women have contextualisations of PA/ST that may not coincide with those of researchers, health professionals and policy makers, and lack awareness of the intensity of PA in which they engage and the health risks of high levels of ST. These findings highlight the need for objective measures of PA and ST in this population combined with in-depth qualitative assessments to provide more accurate assessments of these behaviours. This information can subsequently be used to develop health promotion messages and interventions focusing on increasing duration and/or intensity levels of daily

  8. Mathematics Objectives and Measurement Specifications 1986-1990. Exit Level. Texas Educational Assessment of Minimum Skills (TEAMS).

    Science.gov (United States)

    Texas Education Agency, Austin. Div. of Educational Assessment.

    This document lists the objectives for the Texas educational assessment program in mathematics. Eighteen objectives for exit level mathematics are listed, by category: number concepts (4); computation (3); applied computation (5); statistical concepts (3); geometric concepts (2); and algebraic concepts (1). Then general specifications are listed…

  9. Visual Working Memory Capacity for Objects from Different Categories: A Face-Specific Maintenance Effect

    Science.gov (United States)

    Wong, Jason H.; Peterson, Matthew S.; Thompson, James C.

    2008-01-01

    The capacity of visual working memory was examined when complex objects from different categories were remembered. Previous studies have not examined how visual similarity affects object memory, though it has long been known that similar-sounding phonological information interferes with rehearsal in auditory working memory. Here, experiments…

  10. Online decoding of object-based attention using real-time fMRI.

    Science.gov (United States)

    Niazi, Adnan M; van den Broek, Philip L C; Klanke, Stefan; Barth, Markus; Poel, Mannes; Desain, Peter; van Gerven, Marcel A J

    2014-01-01

    Visual attention is used to selectively filter relevant information depending on current task demands and goals. Visual attention is called object-based attention when it is directed to coherent forms or objects in the visual field. This study used real-time functional magnetic resonance imaging for moment-to-moment decoding of attention to spatially overlapped objects belonging to two different object categories. First, a whole-brain classifier was trained on pictures of faces and places. Subjects then saw transparently overlapped pictures of a face and a place, and attended to only one of them while ignoring the other. The category of the attended object, face or place, was decoded on a scan-by-scan basis using the previously trained decoder. The decoder performed at 77.6% accuracy indicating that despite competing bottom-up sensory input, object-based visual attention biased neural patterns towards that of the attended object. Furthermore, a comparison between different classification approaches indicated that the representation of faces and places is distributed rather than focal. This implies that real-time decoding of object-based attention requires a multivariate decoding approach that can detect these distributed patterns of cortical activity. © 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  11. 76 FR 53524 - Culturally Significant Objects Imported for Exhibition Determinations: “Once Upon Many Times...

    Science.gov (United States)

    2011-08-26

    ... DEPARTMENT OF STATE [Public Notice: 7568] Culturally Significant Objects Imported for Exhibition Determinations: ``Once Upon Many Times: Legends and Myths in Himalayan Art'' SUMMARY: Notice is hereby given of... included in the exhibition ``Once Upon Many Times: Legends and Myths in Himalayan Art,'' imported from...

  12. Formal Transformations from Graphically-Based Object-Oriented Representations to Theory-Based Specifications

    Science.gov (United States)

    1996-06-01

    for Software Synthesis." KBSE 󈨡. IEEE, 1993. 51. Kang, Kyo C., et al. Feature-Oriented Domain Analysis ( FODA ) Feasibility Study. Technical Report...Algebra. New York, NY: Chelsea Publishing Company , 1993. 72. Martin, James. Principles of Object-Oriented Analysis and Design. Englewood Cliffs, New...and usefulness in domain analysis and modeling. Rumbaugh uses three distinct views to describe a domain: (1) the object model describes structural

  13. Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks

    OpenAIRE

    Ren, Shaoqing; He, Kaiming; Girshick, Ross; Sun, Jian

    2015-01-01

    State-of-the-art object detection networks depend on region proposal algorithms to hypothesize object locations. Advances like SPPnet and Fast R-CNN have reduced the running time of these detection networks, exposing region proposal computation as a bottleneck. In this work, we introduce a Region Proposal Network (RPN) that shares full-image convolutional features with the detection network, thus enabling nearly cost-free region proposals. An RPN is a fully convolutional network that simultan...

  14. Real-time object detection and semantic segmentation for autonomous driving

    Science.gov (United States)

    Li, Baojun; Liu, Shun; Xu, Weichao; Qiu, Wei

    2018-02-01

    In this paper, we proposed a Highly Coupled Network (HCNet) for joint objection detection and semantic segmentation. It follows that our method is faster and performs better than the previous approaches whose decoder networks of different tasks are independent. Besides, we present multi-scale loss architecture to learn better representation for different scale objects, but without extra time in the inference phase. Experiment results show that our method achieves state-of-the-art results on the KITTI datasets. Moreover, it can run at 35 FPS on a GPU and thus is a practical solution to object detection and semantic segmentation for autonomous driving.

  15. Deep Learning for Real-Time Capable Object Detection and Localization on Mobile Platforms

    Science.gov (United States)

    Particke, F.; Kolbenschlag, R.; Hiller, M.; Patiño-Studencki, L.; Thielecke, J.

    2017-10-01

    Industry 4.0 is one of the most formative terms in current times. Subject of research are particularly smart and autonomous mobile platforms, which enormously lighten the workload and optimize production processes. In order to interact with humans, the platforms need an in-depth knowledge of the environment. Hence, it is required to detect a variety of static and non-static objects. Goal of this paper is to propose an accurate and real-time capable object detection and localization approach for the use on mobile platforms. A method is introduced to use the powerful detection capabilities of a neural network for the localization of objects. Therefore, detection information of a neural network is combined with depth information from a RGB-D camera, which is mounted on a mobile platform. As detection network, YOLO Version 2 (YOLOv2) is used on a mobile robot. In order to find the detected object in the depth image, the bounding boxes, predicted by YOLOv2, are mapped to the corresponding regions in the depth image. This provides a powerful and extremely fast approach for establishing a real-time-capable Object Locator. In the evaluation part, the localization approach turns out to be very accurate. Nevertheless, it is dependent on the detected object itself and some additional parameters, which are analysed in this paper.

  16. Real-time visual tracking of less textured three-dimensional objects on mobile platforms

    Science.gov (United States)

    Seo, Byung-Kuk; Park, Jungsik; Park, Hanhoon; Park, Jong-Il

    2012-12-01

    Natural feature-based approaches are still challenging for mobile applications (e.g., mobile augmented reality), because they are feasible only in limited environments such as highly textured and planar scenes/objects, and they need powerful mobile hardware for fast and reliable tracking. In many cases where conventional approaches are not effective, three-dimensional (3-D) knowledge of target scenes would be beneficial. We present a well-established framework for real-time visual tracking of less textured 3-D objects on mobile platforms. Our framework is based on model-based tracking that efficiently exploits partially known 3-D scene knowledge such as object models and a background's distinctive geometric or photometric knowledge. Moreover, we elaborate on implementation in order to make it suitable for real-time vision processing on mobile hardware. The performance of the framework is tested and evaluated on recent commercially available smartphones, and its feasibility is shown by real-time demonstrations.

  17. Cortical control of object-specific grasp relies on adjustments of both activity and effective connectivity

    DEFF Research Database (Denmark)

    Tia, Banty; Takemi, Mitsuaki; Kosugi, Akito

    2017-01-01

    The cortical mechanisms of grasping have been extensively studied in macaques and humans. Here, we investigated whether common marmosets could rely on similar mechanisms despite striking differences in manual dexterity. Two common marmosets were trained to grasp-and-pull three objects eliciting d...

  18. Stimulus Dependency of Object-Evoked Responses in Human Visual Cortex: An Inverse Problem for Category Specificity

    Science.gov (United States)

    Graewe, Britta; De Weerd, Peter; Farivar, Reza; Castelo-Branco, Miguel

    2012-01-01

    Many studies have linked the processing of different object categories to specific event-related potentials (ERPs) such as the face-specific N170. Despite reports showing that object-related ERPs are influenced by visual stimulus features, there is consensus that these components primarily reflect categorical aspects of the stimuli. Here, we re-investigated this idea by systematically measuring the effects of visual feature manipulations on ERP responses elicited by both structure-from-motion (SFM)-defined and luminance-defined object stimuli. SFM objects elicited a novel component at 200–250 ms (N250) over parietal and posterior temporal sites. We found, however, that the N250 amplitude was unaffected by restructuring SFM stimuli into meaningless objects based on identical visual cues. This suggests that this N250 peak was not uniquely linked to categorical aspects of the objects, but is strongly determined by visual stimulus features. We provide strong support for this hypothesis by parametrically manipulating the depth range of both SFM- and luminance-defined object stimuli and showing that the N250 evoked by SFM stimuli as well as the well-known N170 to static faces were sensitive to this manipulation. Importantly, this effect could not be attributed to compromised object categorization in low depth stimuli, confirming a strong impact of visual stimulus features on object-related ERP signals. As ERP components linked with visual categorical object perception are likely determined by multiple stimulus features, this creates an interesting inverse problem when deriving specific perceptual processes from variations in ERP components. PMID:22363479

  19. The Prototype of Real-time Object Detection System Based on SMS

    Directory of Open Access Journals (Sweden)

    M. Hana Mirza

    2010-08-01

    Full Text Available The powerful algorithm to detect object movement in development of room monitoring system is very urgent. The commond algorithm needs complex computation. In this research, the prototype of real-time object detection system using simple algorithm is developed, i.e. using the determination of the max noise/pixel value and the tolerance threshold of image accurately, and then the system automatically send a SMS (short message services to user when the object movement is detected. The developed prototype used a Logitech QuickCam webcam, a Siemens C45 mobile phone and a data cable, and the Borland Delphi 7 with additional components and Serial PortNG Tvideo as system software. The application also includes a database to store the captured images whenever object movement is detected. The test results by varying conditions of light intensities using a 5-watt light bulb, fluorescent lamp 20 and 40 watts indicate that the application is able to automatically detect the presence of moving objects with 100% success rate. The success rate is strongly influenced by the determination of the max noise/pixel value and the tolerance threshold during system configuration. This application is also capable of sending SMS automatically when the system detects a moving object with an average time of 8.35 seconds.

  20. Association between maternal education and objectively measured physical activity and sedentary time in adolescents

    DEFF Research Database (Denmark)

    Sherar, Lauren B; Griffin, T. P.; Ekelund, U.

    2016-01-01

    Background Investigating socioeconomic variation in physical activity (PA) and sedentary time is important as it may represent a pathway by which socioeconomic position (SEP) leads to ill health. Findings on the association between children's SEP and objectively assessed PA and/or sedentary time......) and regression coefficients combined across studies using random effects metaanalyses. Analyses were conducted in March 2014. Results Adolescents of university educated mothers spent more time sedentary (9.5 min/day, p=0.005) and less time in light activity (10 min/day, p

  1. Emerging Object Representations in the Visual System Predict Reaction Times for Categorization

    Science.gov (United States)

    Ritchie, J. Brendan; Tovar, David A.; Carlson, Thomas A.

    2015-01-01

    Recognizing an object takes just a fraction of a second, less than the blink of an eye. Applying multivariate pattern analysis, or “brain decoding”, methods to magnetoencephalography (MEG) data has allowed researchers to characterize, in high temporal resolution, the emerging representation of object categories that underlie our capacity for rapid recognition. Shortly after stimulus onset, object exemplars cluster by category in a high-dimensional activation space in the brain. In this emerging activation space, the decodability of exemplar category varies over time, reflecting the brain’s transformation of visual inputs into coherent category representations. How do these emerging representations relate to categorization behavior? Recently it has been proposed that the distance of an exemplar representation from a categorical boundary in an activation space is critical for perceptual decision-making, and that reaction times should therefore correlate with distance from the boundary. The predictions of this distance hypothesis have been born out in human inferior temporal cortex (IT), an area of the brain crucial for the representation of object categories. When viewed in the context of a time varying neural signal, the optimal time to “read out” category information is when category representations in the brain are most decodable. Here, we show that the distance from a decision boundary through activation space, as measured using MEG decoding methods, correlates with reaction times for visual categorization during the period of peak decodability. Our results suggest that the brain begins to read out information about exemplar category at the optimal time for use in choice behaviour, and support the hypothesis that the structure of the representation for objects in the visual system is partially constitutive of the decision process in recognition. PMID:26107634

  2. Children’s sedentary behaviour: descriptive epidemiology and associations with objectively-measured sedentary time

    OpenAIRE

    Klitsie, Tessa; Corder, Kirsten; Visscher, Tommy LS; Atkin, Andrew J; Jones, Andrew P; van Sluijs, Esther MF

    2013-01-01

    Background: Little is known regarding the patterning and socio-demographic distribution of multiple sedentary behaviours in children. The aims of this study were to: 1) describe the leisure-time sedentary behaviour of 9-10 year old British children, and 2) establish associations with objectively-measured sedentary time. Methods. Cross-sectional analysis in the SPEEDY study (Sport, Physical activity and Eating behaviour: Environmental Determinants in Young people) (N=1513, 44.3% boys). Twelve ...

  3. The hollow-face illusion: object-specific knowledge, general assumptions or properties of the stimulus?

    Science.gov (United States)

    Hill, Harold; Johnston, Alan

    2007-01-01

    The hollow-face illusion, in which a mask appears as a convex face, is a powerful example of binocular depth inversion occurring with a real object under a wide range of viewing conditions. Explanations of the illusion are reviewed and six experiments reported. In experiment 1 the detrimental effect of figural inversion, evidence for the importance of familiarity, was found for other oriented objects. The inversion effect held for masks lit from the side (experiment 2). The illusion was stronger for a mask rotated by 90 degrees lit from its forehead than from its chin, suggesting that familiar patterns of shading enhance the illusion (experiment 2). There were no effects of light source visibility or any left/right asymmetry (experiment 3). In experiments 4-6 we used a 'virtual' hollow face, with illusion strength quantified by the proportion of noise texture needed to eliminate the illusion. Adding characteristic surface colour enhanced the illusion, consistent with the familiar face pigmentation outweighing additional bottom-up cues (experiment 4). There was no difference between perspective and orthographic projection. Photographic negation reduced, but did not eliminate, the illusion, suggesting shading is important but not essential (experiment 5). Absolute depth was not critical, although a shallower mask was given less extreme convexity ratings (experiment 6). We argue that the illusion arises owing to a convexity preference when the raw data have ambiguous interpretations. However, using a familiar object with typical orientation, shading, and pigmentation greatly enhances the effect.

  4. Methods for providing decision makers with optimal solutions for multiple objectives that change over time

    CSIR Research Space (South Africa)

    Greeff, M

    2010-09-01

    Full Text Available Decision making - with the goal of finding the optimal solution - is an important part of modern life. For example: In the control room of an airport, the goals or objectives are to minimise the risk of airplanes colliding, minimise the time that a...

  5. Time-Correlated Single-Photon Counting Range Profiling of Moving Objects

    Directory of Open Access Journals (Sweden)

    Hedborg Julia

    2016-01-01

    TCSPC is a statistic method that requires an acquisition time and therefore the range profile of a non-stationary object (target may be corrupted. Here, we present results showing that it is possible to reconstruct the range profile of a moving target and calculate the velocity of the target.

  6. Objectively measured total and occupational sedentary time in three work settings

    NARCIS (Netherlands)

    Dommelen, P. van; Coffeng, J. K.; Ploeg, H.P. van der; Beek, A.J. van der; Boot, C.R.; Hendriksen, I.J.

    2016-01-01

    Background. Sedentary behaviour increases the risk for morbidity. Our primary aim is to determine the proportion and factors associated with objectively measured total and occupational sedentary time in three work settings. Secondary aim is to study the proportion of physical activity and prolonged

  7. Time coordination of heterogeneous distance protections using a domain specific language

    OpenAIRE

    Marcin Kowalski; Jan Magott

    2012-01-01

    BACKGROUND: Distance protections are widely used in protection of energy transmission lines, but their time coordination is still an important and difficult problem. Inappropriate configuration leads to a hazard event: remote circuit breaker tripping provided the local circuit breaker can be opened, which severely impairs power system operation.OBJECTIVE: To describe a method and provide software tools to alleviate the hazard in power systems.METHODS: A domain specific language (DSL) for repr...

  8. 76 FR 24831 - Site-Specific Analyses for Demonstrating Compliance With Subpart C Performance Objectives

    Science.gov (United States)

    2011-05-03

    ...-level radioactive waste disposal facilities to conduct site-specific analyses to demonstrate compliance... public health and safety, these amendments would enhance the safe disposal of low-level radioactive waste... would be to enhance the safe disposal of low-level radioactive waste. The NRC is also proposing...

  9. General and Specific Effects of Lexicon in Grammar: Determiner and Object Pronoun Omissions in Child Spanish

    Science.gov (United States)

    Perez-Leroux, Ana Teresa; Castilla-Earls, Anny Patricia; Brunner, Jerry

    2012-01-01

    Purpose: This study explores the hypothesis that vocabulary growth can have 2 types of effects in morphosyntactic development. One is a general effect, where vocabulary growth globally determines utterance complexity, defined in terms of sentence length and rates of subordination. There are also specific effects, where vocabulary size has a…

  10. Gist in time: Scene semantics and structure enhance recall of searched objects.

    Science.gov (United States)

    Josephs, Emilie L; Draschkow, Dejan; Wolfe, Jeremy M; Võ, Melissa L-H

    2016-09-01

    Previous work has shown that recall of objects that are incidentally encountered as targets in visual search is better than recall of objects that have been intentionally memorized (Draschkow, Wolfe, & Võ, 2014). However, this counter-intuitive result is not seen when these tasks are performed with non-scene stimuli. The goal of the current paper is to determine what features of search in a scene contribute to higher recall rates when compared to a memorization task. In each of four experiments, we compare the free recall rate for target objects following a search to the rate following a memorization task. Across the experiments, the stimuli include progressively more scene-related information. Experiment 1 provides the spatial relations between objects. Experiment 2 adds relative size and depth of objects. Experiments 3 and 4 include scene layout and semantic information. We find that search leads to better recall than explicit memorization in cases where scene layout and semantic information are present, as long as the participant has ample time (2500ms) to integrate this information with knowledge about the target object (Exp. 4). These results suggest that the integration of scene and target information not only leads to more efficient search, but can also contribute to stronger memory representations than intentional memorization. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. State-of-the-art Versus Time-triggered Object Tracking in Advanced Driver Assistance Systems

    Directory of Open Access Journals (Sweden)

    Moritz Koplin

    2013-04-01

    Full Text Available Most state-of-the-art driver assistance systems cannot guarantee that real-time images of object states are updated within a given time interval, because the object state observations are typically sampled by uncontrolled sensors and transmitted via an indeterministic bus system such as CAN. To overcome this shortcoming, a paradigm shift toward time-triggered advanced driver assistance systems based on a deterministic bus system, such as FlexRay, is under discussion. In order to prove the feasibility of this paradigm shift, this paper develops different models of a state-of-the-art and a time-triggered advanced driver assistance system based on multi-sensor object tracking and compares them with regard to their mean performance. The results show that while the state-of-the-art model is advantageous in scenarios with low process noise, it is outmatched by the time-triggered model in the case of high process noise, i.e., in complex situations with high dynamic.

  12. Real-time Pipeline for Object Modeling and Grasping Pose Selection via Superquadric Functions

    Directory of Open Access Journals (Sweden)

    Giulia Vezzani

    2017-11-01

    Full Text Available This work provides a novel real-time pipeline for modeling and grasping of unknown objects with a humanoid robot. Such a problem is of great interest for the robotic community, since conventional approaches fail when the shape, dimension, or pose of the objects are missing. Our approach reconstructs in real-time a model for the object under consideration and represents the robot hand both with proper and mathematically usable models, i.e., superquadric functions. The volume graspable by the hand is represented by an ellipsoid and is defined a priori, because the shape of the hand is known in advance. The superquadric representing the object is obtained in real-time from partial vision information instead, e.g., one stereo view of the object under consideration, and provides an approximated 3D full model. The optimization problem we formulate for the grasping pose computation is solved online by using the Ipopt software package and, thus, does not require off-line computation or learning. Even though our approach is for a generic humanoid robot, we developed a complete software architecture for executing this approach on the iCub humanoid robot. Together with that, we also provide a tutorial on how to use this framework. We believe that our work, together with the available code, is of a strong utility for the iCub community for three main reasons: object modeling and grasping are relevant problems for the robotic community, our code can be easily applied on every iCub, and the modular structure of our framework easily allows extensions and communications with external code.

  13. Bi-Objective Flexible Job-Shop Scheduling Problem Considering Energy Consumption under Stochastic Processing Times.

    Science.gov (United States)

    Yang, Xin; Zeng, Zhenxiang; Wang, Ruidong; Sun, Xueshan

    2016-01-01

    This paper presents a novel method on the optimization of bi-objective Flexible Job-shop Scheduling Problem (FJSP) under stochastic processing times. The robust counterpart model and the Non-dominated Sorting Genetic Algorithm II (NSGA-II) are used to solve the bi-objective FJSP with consideration of the completion time and the total energy consumption under stochastic processing times. The case study on GM Corporation verifies that the NSGA-II used in this paper is effective and has advantages to solve the proposed model comparing with HPSO and PSO+SA. The idea and method of the paper can be generalized widely in the manufacturing industry, because it can reduce the energy consumption of the energy-intensive manufacturing enterprise with less investment when the new approach is applied in existing systems.

  14. Site-specific sediment clean-up objectives developed by the sediment quality triad

    International Nuclear Information System (INIS)

    Redman, S.; Janisch, T.

    1995-01-01

    Sediment chemistry, sediment toxicity, and benthic macroinvertebrate community data were collected and evaluated in concert (1) to characterize adverse effects of hydrocarbon and metal contaminants in the sediments of a small inlet of Superior Bay, Lake Superior and a tributary creek and (2) to derive numeric objectives for the clean up of this system. Sediments from reference locations and eight study sites were analyzed for a range of contaminants, including hydrocarbons (measured both as diesel range organics (DRO) and oil and grease), lead, chromium, and ammonia. A range of sediment toxicity was observed across the eight study sites using a variety of tests and endpoints: Hyalella azteca (10 day survival and growth), Chironomus tentans (10 day survival and growth), Ceriodaphnia dubia (48 hour survival), and Daphnia magna (48 hour survival and 10 day survival and reproduction). A range of alterations of the benthic macroinvertebrate community compared with communities from reference locations were observed. Benthic community alterations were summarized quantitatively by taxa richness and Shannon-Weiner mean diversity. Lowest effect levels determined through this study included 150 microg/g dry sediment for DRO (as measured in this study) and 40 microg/g dry sediment for lead. Effects thresholds determined through this study included 1,500 microg/g dry sediment for DRO and 90 microg/g dry sediment for lead. These levels and concentrations measured in relevant reference locations are being used to define objectives for sediment clean up in the inlet and creek

  15. Forebrain-Specific Loss of BMPRII in Mice Reduces Anxiety and Increases Object Exploration

    OpenAIRE

    McBrayer, Zofeyah L.; Dimova, Jiva; Pisansky, Marc T.; Sun, Mu; Beppu, Hideyuki; Gewirtz, Jonathan C.; O’Connor, Michael B.

    2015-01-01

    To investigate the role of Bone Morphogenic Protein Receptor Type II (BMPRII) in learning, memory, and exploratory behavior in mice, a tissue-specific knockout of BMPRII in the post-natal hippocampus and forebrain was generated. We found that BMPRII mutant mice had normal spatial learning and memory in the Morris water maze, but showed significantly reduced swimming speeds with increased floating behavior. Further analysis using the Porsolt Swim Test to investigate behavioral despair did not ...

  16. IAEA co-ordinated research programme on the transport of low specific activity materials and surface contaminated objects

    International Nuclear Information System (INIS)

    Gray, I.L.S.

    2000-01-01

    The International Atomic Energy Agency (IAEA) prepares regulations for the safe transport of radioactive material, and periodically revised editions of these are published. These regulations are adopted by individual countries across the world and by international organisations concerned with transport. Whilst it is desirable to have a stable framework of regulatory requirements, there is also a need to take account of technical advances and operational experience and revise the regulations. From time to time Co-ordinated Research Programmes (CRP) are established to investigate particular areas of the regulations that are giving concern. In 1996 the IAEA Standing Advisory Group on the Transport of Radioactive Material (SAGSTRAM) concluded that the requirements for classification, packaging and transport of low specific activity (LSA) material and surface contaminated objects (SCO) did not always have a strong radiation protection basis. Accordingly SAGSTRAM established a CRP with an overall objective to develop a dose-based approach for establishing LSA/SCO requirements. Six countries are participating in this CRP. Brazil, Canada, France, Germany, United Kingdom and United States. Each country is carrying out work that is outlined in agreements with the IAEA, with the work aimed at meeting the specific objective of the agreement and also contributing to achieving the overall objective of the CRP. Completion of the CRP usually involves the preparation of an IAEA TECDOC by a Consultant Services Meeting (CSM), and this TECDOC will summarise the work performed under the CRP and include any recommendations made by the CRP. Following the establishment of the CRP in 1997, the first Research Co-ordination Meeting (RCM) was held in December 1997. The second RCM was held in March 1999, with the final RCM planned for the end of 2000. The work being carried out by Brazil and Canada is focused upon the transport of uranium and thorium ores, and is a mixture of theoretical and

  17. Object-orientated DBMS techniques for time-oriented medical record.

    Science.gov (United States)

    Pinciroli, F; Combi, C; Pozzi, G

    1992-01-01

    In implementing time-orientated medical record (TOMR) management systems, use of a relational model played a big role. Many applications have been developed to extend query and data manipulation languages to temporal aspects of information. Our experience in developing TOMR revealed some deficiencies inside the relational model, such as: (a) abstract data type definition; (b) unified view of data, at a programming level; (c) management of temporal data; (d) management of signals and images. We identified some first topics to face by an object-orientated approach to database design. This paper describes the first steps in designing and implementing a TOMR by an object-orientated DBMS.

  18. A multiple ship routing and speed optimization problem under time, cost and environmental objectives

    DEFF Research Database (Denmark)

    Wen, M.; Pacino, Dario; Kontovas, C.A.

    2017-01-01

    The purpose of this paper is to investigate a multiple ship routing and speed optimization problem under time, cost and environmental objectives. A branch and price algorithm as well as a constraint programming model are developed that consider (a) fuel consumption as a function of payload, (b......) fuel price as an explicit input, (c) freight rate as an input, and (d) in-transit cargo inventory costs. The alternative objective functions are minimum total trip duration, minimum total cost and minimum emissions. Computational experience with the algorithm is reported on a variety of scenarios....

  19. Objectively-measured outdoor time and physical and psychological function among older adults.

    Science.gov (United States)

    Harada, Kazuhiro; Lee, Sangyoon; Lee, Sungchul; Bae, Seongryu; Harada, Kenji; Suzuki, Takao; Shimada, Hiroyuki

    2017-10-01

    Objective measurements of outdoor time are essential to establishing evidence about the health benefits of going outdoors among older adults. To better understanding the health benefits of going outdoors, clarification of potential mediators to connect going outdoors with health benefits is necessary. The present study aimed to investigate associations of objectively-measured outdoor time with older adults' physical and psychological function, and examine the mediating role of physical activity on these associations. Baseline data from a randomized control trial of physical activity among older adults with global cognitive impairment was used. Data from 192 participants were analyzed. Measures included steps-per-day, objectively-measured outdoor time per day using global positioning systems, physical function (cardiorespiratory fitness, lower-extremity strength), psychological function (depression, well-being) and basic factors. Path analysis showed that outdoor time was significantly associated with steps-per-day (path coefficient = 0.23) and depression (path coefficient = -0.16). Outdoor time was not directly associated with cardiorespiratory fitness, lower-extremity strength and well-being. However, steps-per-day was associated with cardiorespiratory fitness (path coefficient = 0.18), lower-extremity strength (path coefficient = -0.22) and well-being (path coefficient = 0.14). We found that objectively-measured outdoor time was indirectly associated with physical function, and both directly and indirectly with psychological function through physical activity among older adults. This finding indicates that going outdoors influences older adults' health outcomes, and is mainly mediated by physical activity. Geriatr Gerontol Int 2017; 17: 1455-1462. © 2016 Japan Geriatrics Society.

  20. Action semantics: A unifying conceptual framework for the selective use of multimodal and modality-specific object knowledge.

    Science.gov (United States)

    van Elk, Michiel; van Schie, Hein; Bekkering, Harold

    2014-06-01

    Our capacity to use tools and objects is often considered one of the hallmarks of the human species. Many objects greatly extend our bodily capabilities to act in the physical world, such as when using a hammer or a saw. In addition, humans have the remarkable capability to use objects in a flexible fashion and to combine multiple objects in complex actions. We prepare coffee, cook dinner and drive our car. In this review we propose that humans have developed declarative and procedural knowledge, i.e. action semantics that enables us to use objects in a meaningful way. A state-of-the-art review of research on object use is provided, involving behavioral, developmental, neuropsychological and neuroimaging studies. We show that research in each of these domains is characterized by similar discussions regarding (1) the role of object affordances, (2) the relation between goals and means in object use and (3) the functional and neural organization of action semantics. We propose a novel conceptual framework of action semantics to address these issues and to integrate the previous findings. We argue that action semantics entails both multimodal object representations and modality-specific sub-systems, involving manipulation knowledge, functional knowledge and representations of the sensory and proprioceptive consequences of object use. Furthermore, we argue that action semantics are hierarchically organized and selectively activated and used depending on the action intention of the actor and the current task context. Our framework presents an integrative account of multiple findings and perspectives on object use that may guide future studies in this interdisciplinary domain. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. Tracking of multiple objects with time-adjustable composite correlation filters

    Science.gov (United States)

    Ruchay, Alexey; Kober, Vitaly; Chernoskulov, Ilya

    2017-09-01

    An algorithm for tracking of multiple objects in video based on time-adjustable adaptive composite correlation filtering is proposed. For each frame a bank of composite correlation filters are designed in such a manner to provide invariance to pose, occlusion, clutter, and illumination changes. The filters are synthesized with the help of an iterative algorithm, which optimizes the discrimination capability for each object. The filters are adapted to the objects changes online using information from the current and past scene frames. Results obtained with the proposed algorithm using real-life scenes are presented and compared with those obtained with state-of-the-art tracking methods in terms of detection efficiency, tracking accuracy, and speed of processing.

  2. Multi-objective optimization model of CNC machining to minimize processing time and environmental impact

    Science.gov (United States)

    Hamada, Aulia; Rosyidi, Cucuk Nur; Jauhari, Wakhid Ahmad

    2017-11-01

    Minimizing processing time in a production system can increase the efficiency of a manufacturing company. Processing time are influenced by application of modern technology and machining parameter. Application of modern technology can be apply by use of CNC machining, one of the machining process can be done with a CNC machining is turning. However, the machining parameters not only affect the processing time but also affect the environmental impact. Hence, optimization model is needed to optimize the machining parameters to minimize the processing time and environmental impact. This research developed a multi-objective optimization to minimize the processing time and environmental impact in CNC turning process which will result in optimal decision variables of cutting speed and feed rate. Environmental impact is converted from environmental burden through the use of eco-indicator 99. The model were solved by using OptQuest optimization software from Oracle Crystal Ball.

  3. Objective Sedentary Time, Moderate-to-Vigorous Physical Activity, and Physical Capability in a British Cohort

    Science.gov (United States)

    KEEVIL, VICTORIA L.; COOPER, ANDREW J. M.; WIJNDAELE, KATRIEN; LUBEN, ROBERT; WAREHAM, NICHOLAS J.; BRAGE, SOREN; KHAW, KAY-TEE

    2016-01-01

    ABSTRACT Purpose Sedentariness has been proposed as an independent risk factor for poor health. However, few studies have considered associations of sedentary time (ST) with physical functional health independent of time spent in moderate-to-vigorous physical activity (MVPA). Methods Community-based men and women (n = 8623, 48–92 yr old) in the European Prospective Investigation of Cancer—Norfolk study attended a health examination for objective measurement of physical capability, including grip strength (Smedley dynamometer (kg)), usual walking speed (UWS (cm·s−1)), and timed chair stand speed (TCSS (stands per minute)). Of these, 4051 participants wore an accelerometer (GT1M ActiGraph) for 7 d to estimate time spent in MVPA (MVPA, ≥1952 counts per minute) and ST (ST, 0.05). Conclusions More time spent in MVPA was associated with higher physical capability, but there were no independent ST associations. PMID:26501232

  4. Identification of Auditory Object-Specific Attention from Single-Trial Electroencephalogram Signals via Entropy Measures and Machine Learning

    Directory of Open Access Journals (Sweden)

    Yun Lu

    2018-05-01

    Full Text Available Existing research has revealed that auditory attention can be tracked from ongoing electroencephalography (EEG signals. The aim of this novel study was to investigate the identification of peoples’ attention to a specific auditory object from single-trial EEG signals via entropy measures and machine learning. Approximate entropy (ApEn, sample entropy (SampEn, composite multiscale entropy (CmpMSE and fuzzy entropy (FuzzyEn were used to extract the informative features of EEG signals under three kinds of auditory object-specific attention (Rest, Auditory Object1 Attention (AOA1 and Auditory Object2 Attention (AOA2. The linear discriminant analysis and support vector machine (SVM, were used to construct two auditory attention classifiers. The statistical results of entropy measures indicated that there were significant differences in the values of ApEn, SampEn, CmpMSE and FuzzyEn between Rest, AOA1 and AOA2. For the SVM-based auditory attention classifier, the auditory object-specific attention of Rest, AOA1 and AOA2 could be identified from EEG signals using ApEn, SampEn, CmpMSE and FuzzyEn as features and the identification rates were significantly different from chance level. The optimal identification was achieved by the SVM-based auditory attention classifier using CmpMSE with the scale factor τ = 10. This study demonstrated a novel solution to identify the auditory object-specific attention from single-trial EEG signals without the need to access the auditory stimulus.

  5. Balancing Exploration, Uncertainty Representation and Computational Time in Many-Objective Reservoir Policy Optimization

    Science.gov (United States)

    Zatarain-Salazar, J.; Reed, P. M.; Quinn, J.; Giuliani, M.; Castelletti, A.

    2016-12-01

    As we confront the challenges of managing river basin systems with a large number of reservoirs and increasingly uncertain tradeoffs impacting their operations (due to, e.g. climate change, changing energy markets, population pressures, ecosystem services, etc.), evolutionary many-objective direct policy search (EMODPS) solution strategies will need to address the computational demands associated with simulating more uncertainties and therefore optimizing over increasingly noisy objective evaluations. Diagnostic assessments of state-of-the-art many-objective evolutionary algorithms (MOEAs) to support EMODPS have highlighted that search time (or number of function evaluations) and auto-adaptive search are key features for successful optimization. Furthermore, auto-adaptive MOEA search operators are themselves sensitive to having a sufficient number of function evaluations to learn successful strategies for exploring complex spaces and for escaping from local optima when stagnation is detected. Fortunately, recent parallel developments allow coordinated runs that enhance auto-adaptive algorithmic learning and can handle scalable and reliable search with limited wall-clock time, but at the expense of the total number of function evaluations. In this study, we analyze this tradeoff between parallel coordination and depth of search using different parallelization schemes of the Multi-Master Borg on a many-objective stochastic control problem. We also consider the tradeoff between better representing uncertainty in the stochastic optimization, and simplifying this representation to shorten the function evaluation time and allow for greater search. Our analysis focuses on the Lower Susquehanna River Basin (LSRB) system where multiple competing objectives for hydropower production, urban water supply, recreation and environmental flows need to be balanced. Our results provide guidance for balancing exploration, uncertainty, and computational demands when using the EMODPS

  6. Lengthening Temporalis Myoplasty: Objective Outcomes and Site-Specific Quality-of-Life Assessment.

    Science.gov (United States)

    Panciera, Davide Thomas; Sampieri, Claudio; Deganello, Alberto; Danesi, Giovanni

    2017-12-01

    Objective Evaluate outcomes of the lengthening temporalis myoplasty in facial reanimations. Study Design Case series with planned data collection. Setting Ospedali Riuniti, Bergamo, and AOUC Careggi, Florence, Italy. Subjects and Methods From 2011 to 2016, 11 patients underwent lengthening temporalis myoplasty; demographic data were collected for each. Pre- and postoperative photographs and videos were recorded and used to measure the smile angle and the excursion of the oral commissure, according to the SMILE system (Scaled Measurements of Improvement in Lip Excursion). All patients were tested with the Facial Disability Index, and they also completed a questionnaire about the adherence to physiotherapy indications. Results All patients demonstrated a significant improvement in functional parameters and in quality of life. On the reanimated side, the mean z-line and a-value, measured when smiling, significantly improved in all patients: from 22.6 mm (95% CI, 20.23-25.05) before surgery to 30.9 mm (95% CI, 27.82-33.99) after surgery ( P smile at the reanimated side, was 3.1 mm (95% CI, 1.30-4.88) for the z-line and 3.3° (95% CI, 1.26°-5.29°) for the a-value. The Facial Disability Index score increased from a preoperative mean of 33.4 points (95% CI, 28.25-38.66) to 49.9 points (95% CI, 47.21-52.60) postoperatively ( P smile reanimation, with satisfying functional and quality-of-life outcomes.

  7. Worst-case execution time analysis-driven object cache design

    DEFF Research Database (Denmark)

    Huber, Benedikt; Puffitsch, Wolfgang; Schoeberl, Martin

    2012-01-01

    result in a WCET analysis‐friendly design. Aiming for a time‐predictable design, we therefore propose to employ WCET analysis techniques for the design space exploration of processor architectures. We evaluated different object cache configurations using static analysis techniques. The number of field......Hard real‐time systems need a time‐predictable computing platform to enable static worst‐case execution time (WCET) analysis. All performance‐enhancing features need to be WCET analyzable. However, standard data caches containing heap‐allocated data are very hard to analyze statically....... In this paper we explore a new object cache design, which is driven by the capabilities of static WCET analysis. Simulations of standard benchmarks estimating the expected average case performance usually drive computer architecture design. The design decisions derived from this methodology do not necessarily...

  8. Testing of toxicity based methods to develop site specific clean up objectives - phase 1: Toxicity protocol screening and applicability

    International Nuclear Information System (INIS)

    Hamilton, H.; Kerr, D.; Thorne, W.; Taylor, B.; Zadnik, M.; Goudey, S.; Birkholz, D.

    1994-03-01

    A study was conducted to develop a cost-effective and practical protocol for using bio-assay based toxicity assessment methods for remediation of decommissioned oil and gas production, and processing facilities. The objective was to generate site-specific remediation criteria for contaminated sites. Most companies have used the chemical-specific approach which, however, did not meet the ultimate land use goal of agricultural production. The toxicity assessment method described in this study dealt with potential impairment to agricultural crop production and natural ecosystems. Human health concerns were not specifically addressed. It was suggested that chemical-specific methods should be used when human health concerns exist. . Results showed that toxicity tests will more directly identify ecological stress caused by site contamination than chemical-specific remediation criteria, which can be unnecessarily protective. 11 refs., 7 tabs., 6 figs

  9. Objectively Measured Total and Occupational Sedentary Time in Three Work Settings

    OpenAIRE

    van Dommelen, Paula; Coffeng, Jennifer K.; van der Ploeg, Hidde P.; van der Beek, Allard J.; Boot, C?cile R. L.; Hendriksen, Ingrid J. M.

    2016-01-01

    Background. Sedentary behaviour increases the risk for morbidity. Our primary aim is to determine the proportion and factors associated with objectively measured total and occupational sedentary time in three work settings. Secondary aim is to study the proportion of physical activity and prolonged sedentary bouts. Methods. Data were obtained using ActiGraph accelerometers from employees of: 1) a financial service provider (n = 49 men, 31 women), 2) two research institutes (n = 30 men, 57 wom...

  10. Temperament and Objectively Measured Physical Activity and Sedentary Time among Canadian Preschoolers

    OpenAIRE

    Jennifer D. Irwin; Andrew M. Johnson; Leigh M. Vanderloo; Shauna M. Burke; Patricia Tucker

    2015-01-01

    This study sought to assess the influence of preschoolers' temperament on their objectively measured physical activity and sedentary time. Actical? accelerometers were used to measure preschoolers' from London, Canada's (n?=?216; 2.5?5?years) physical activity and sedentary levels during childcare hours (5 consecutive days; 15?s epoch). The Child Temperament Questionnaire (CTQ) was used to assess child temperament via parent/guardian report. The six subscales of the CTQ (i.e., reaction to foo...

  11. From climate change uncertainties to strategic options. Objectives, instruments, timing issues

    Energy Technology Data Exchange (ETDEWEB)

    Philibert, C [French Agency for Environment and Energy Management, Paris (France)

    1996-12-31

    The question of climate change is characterised by major uncertainties. For some, this means that no action should be undertaken for the time being. For others, forceful action is needed to avoid potentially disastrous consequences: targets and timetables for emission reductions must be agreed. This communication is an attempt to suggest a third alternative, with two main conclusions. The international decision process should focus on instruments and degrees of effort, rather than on `emission trajectories` (the evolution of emission levels over time), rather than on quantitative objectives tied to precise timetables. In this perspective action can start right away. (author)

  12. From climate change uncertainties to strategic options. Objectives, instruments, timing issues

    Energy Technology Data Exchange (ETDEWEB)

    Philibert, C. [French Agency for Environment and Energy Management, Paris (France)

    1995-12-31

    The question of climate change is characterised by major uncertainties. For some, this means that no action should be undertaken for the time being. For others, forceful action is needed to avoid potentially disastrous consequences: targets and timetables for emission reductions must be agreed. This communication is an attempt to suggest a third alternative, with two main conclusions. The international decision process should focus on instruments and degrees of effort, rather than on `emission trajectories` (the evolution of emission levels over time), rather than on quantitative objectives tied to precise timetables. In this perspective action can start right away. (author)

  13. Association between birth weight and objectively measured sedentary time is mediated by central adiposity

    DEFF Research Database (Denmark)

    Hildebrand, Maria; Kolle, Elin; Hansen, Bjørge H

    2015-01-01

    BACKGROUND: Birth weight is an early correlate of disease later in life, and animal studies suggest that low birth weight is associated with reduced activity and increased sedentary time. Whether birth weight predicts later sedentary time in humans is uncertain. OBJECTIVES: We examined the relation...... between birth weight and sedentary time in youth and examined whether this association was mediated by central adiposity. DESIGN: We used pooled cross-sectional data from 8 observational studies conducted between 1997 and 2007 that consisted of 10,793 youth (boys: 47%) aged 6-18 y from the International...... Children's Accelerometry Database. Birth weight was measured in hospitals or maternally reported, sedentary time was assessed by using accelerometry (

  14. Effect of Colour of Object on Simple Visual Reaction Time in Normal Subjects

    Directory of Open Access Journals (Sweden)

    Sunita B. Kalyanshetti

    2014-01-01

    Full Text Available The measure of simple reaction time has been used to evaluate the processing speed of CNS and the co-ordination between the sensory and motor systems. As the reaction time is influenced by different factors; the impact of colour of objects in modulating the reaction time has been investigated in this study. 200 healthy volunteers (female gender 100 and male gender100 of age group 18-25 yrs were included as subjects. The subjects were presented with two visual stimuli viz; red and green light by using an electronic response analyzer. Paired‘t’ test for comparison of visual reaction time for red and green colour in male gender shows p value<0.05 whereas in female gender shows p<0.001. It was observed that response latency for red colour was lesser than that of green colour which can be explained on the basis of trichromatic theory.

  15. Сriminological crime prevention: the concept, the specifics, the structure, the object of precautionary influence

    Directory of Open Access Journals (Sweden)

    В. В. Голіна

    2015-11-01

    Full Text Available Problem setting. Crime is one of the oldest existing forms of social life, despite the burning desire of human to destroy it. World history persuades explicitly that cruel, inhumane punishment punishments are inefficient to prevent crime. It’s necessary to rebuild human behavior, and this is possible through the elimination of various stimuli that enhance human passions and lead to irrational, destructive behavior. Recent research and publications analysis. Theory of combating crime primarily through its prevention has been substantively enriched during XIX-XXI centuries through scientific works of domestic and foreign criminologists and other researchers, which laid the philosophical, sociological, moral, psychological, social, anthropological, organizational, managerial, economic, educational, penitentiary and other types of crime prevention (Yu. M. Antonyan, A. Herry, A. Quetelet, C. Lombroso, D. Drill, E. Durkheim, G. Tarde, E. Ferry, R. Garofalo, A. Kystyakivskyi, M. Gernet, A. Gertsenzon, E. Sutherland, N. Kuznetsov, V. Kudryavtsev, A. Sakharov, I. Karpets, A. Zelinsky, V. Dryomin, O. Tulyakov, O. Litvinov, A. Zakalyuk, V. Shakun, B. Golovkin etc.. Paper objective is providing a thorough analysis of a range of issues, related to the criminological crime prevention as an essential part of special criminological crime prevention. Paper main body. Crime is a complex social phenomenon whose causes and conditions are usually associated with a genetic predisposition to decline form normal behavior, along with the defects and imperfections of the society. Crime prevention is state social policy aimed at overcoming dangerous criminal contradictions in social relations in order to reach positive resolution and the gradual elimination (so-called general social prevention along with proactive practice of combating criminal offenses at various stages. Crime prevention can be divided into several types: prevention in advance, restrictive prevention

  16. Real-time prostate-specific antigen detection with prostate-specific antigen imprinted capacitive biosensors

    Energy Technology Data Exchange (ETDEWEB)

    Ertürk, Gizem [Department of Biotechnology, Lund University, Lund (Sweden); Department of Biology, Hacettepe University, Ankara (Turkey); Hedström, Martin [Department of Biotechnology, Lund University, Lund (Sweden); CapSenze HB, Medicon Village, SE-223 63 Lund (Sweden); Tümer, M. Aşkın [Department of Biology, Hacettepe University, Ankara (Turkey); Denizli, Adil [Department of Chemistry, Hacettepe University, Ankara (Turkey); Mattiasson, Bo, E-mail: Bo.Mattiasson@biotek.lu.se [Department of Biotechnology, Lund University, Lund (Sweden); CapSenze HB, Medicon Village, SE-223 63 Lund (Sweden)

    2015-09-03

    Prostate specific antigen (PSA) is a valuable biomarker for early detection of prostate cancer, the third most common cancer in men. Ultrasensitive detection of PSA is crucial to screen the prostate cancer in an early stage and to detect the recurrence of the disease after treatment. In this report, microcontact-PSA imprinted (PSA-MIP) capacitive biosensor chip was developed for real-time, highly sensitive and selective detection of PSA. PSA-MIP electrodes were prepared in the presence of methacrylic acid (MAA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the cross-linker via UV polymerization. Immobilized Anti-PSA antibodies on electrodes (Anti-PSA) for capacitance measurements were also prepared to compare the detection performances of both methods. The electrodes were characterized by atomic force microscopy (AFM), scanning electron microscopy (SEM) and cyclic voltammetry (CV) and real-time PSA detection was performed with standard PSA solutions in the concentration range of 10 fg mL{sup −1}–100 ng mL{sup −1}. The detection limits were found as 8.0 × 10{sup −5} ng mL{sup −1} (16 × 10{sup −17} M) and 6.0 × 10{sup −4} ng mL{sup −1} (12 × 10{sup −16} M) for PSA-MIP and Anti-PSA electrodes, respectively. Selectivity studies were performed against HSA and IgG and selectivity coefficients were calculated. PSA detection was also carried out from diluted human serum samples and finally, reproducibility of the electrodes was tested. The results are promising and show that when the sensitivity of the capacitive system is combined with the selectivity and reproducibility of the microcontact-imprinting procedure, the resulting system might be used successfully for real-time detection of various analytes even in very low concentrations. - Highlights: • Microcontact imprinting method was used for preparing the sensor chip for capacitive biosensing. • High sensitivity was obtained. • Good selectivity was

  17. Real-time prostate-specific antigen detection with prostate-specific antigen imprinted capacitive biosensors

    International Nuclear Information System (INIS)

    Ertürk, Gizem; Hedström, Martin; Tümer, M. Aşkın; Denizli, Adil; Mattiasson, Bo

    2015-01-01

    Prostate specific antigen (PSA) is a valuable biomarker for early detection of prostate cancer, the third most common cancer in men. Ultrasensitive detection of PSA is crucial to screen the prostate cancer in an early stage and to detect the recurrence of the disease after treatment. In this report, microcontact-PSA imprinted (PSA-MIP) capacitive biosensor chip was developed for real-time, highly sensitive and selective detection of PSA. PSA-MIP electrodes were prepared in the presence of methacrylic acid (MAA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the cross-linker via UV polymerization. Immobilized Anti-PSA antibodies on electrodes (Anti-PSA) for capacitance measurements were also prepared to compare the detection performances of both methods. The electrodes were characterized by atomic force microscopy (AFM), scanning electron microscopy (SEM) and cyclic voltammetry (CV) and real-time PSA detection was performed with standard PSA solutions in the concentration range of 10 fg mL"−"1–100 ng mL"−"1. The detection limits were found as 8.0 × 10"−"5 ng mL"−"1 (16 × 10"−"1"7 M) and 6.0 × 10"−"4 ng mL"−"1 (12 × 10"−"1"6 M) for PSA-MIP and Anti-PSA electrodes, respectively. Selectivity studies were performed against HSA and IgG and selectivity coefficients were calculated. PSA detection was also carried out from diluted human serum samples and finally, reproducibility of the electrodes was tested. The results are promising and show that when the sensitivity of the capacitive system is combined with the selectivity and reproducibility of the microcontact-imprinting procedure, the resulting system might be used successfully for real-time detection of various analytes even in very low concentrations. - Highlights: • Microcontact imprinting method was used for preparing the sensor chip for capacitive biosensing. • High sensitivity was obtained. • Good selectivity was demonstrated. • Stability of

  18. Real-time tracking of visually attended objects in virtual environments and its application to LOD.

    Science.gov (United States)

    Lee, Sungkil; Kim, Gerard Jounghyun; Choi, Seungmoon

    2009-01-01

    This paper presents a real-time framework for computationally tracking objects visually attended by the user while navigating in interactive virtual environments. In addition to the conventional bottom-up (stimulus-driven) saliency map, the proposed framework uses top-down (goal-directed) contexts inferred from the user's spatial and temporal behaviors, and identifies the most plausibly attended objects among candidates in the object saliency map. The computational framework was implemented using GPU, exhibiting high computational performance adequate for interactive virtual environments. A user experiment was also conducted to evaluate the prediction accuracy of the tracking framework by comparing objects regarded as visually attended by the framework to actual human gaze collected with an eye tracker. The results indicated that the accuracy was in the level well supported by the theory of human cognition for visually identifying single and multiple attentive targets, especially owing to the addition of top-down contextual information. Finally, we demonstrate how the visual attention tracking framework can be applied to managing the level of details in virtual environments, without any hardware for head or eye tracking.

  19. Time-Lapse Videos for Physics Education: Specific Examples

    Science.gov (United States)

    Vollmer, Michael; Möllmann, Klaus-Peter

    2018-01-01

    There are many physics experiments with long time scales such that they are usually neither shown in the physics class room nor in student labs. However, they can be easily recorded with time-lapse cameras and the respective time-lapse videos allow qualitative and/or quantitative analysis of the underlying physics. Here, we present some examples…

  20. Individual and environmental correlates of objectively measured sedentary time in Dutch and Belgian adults.

    Directory of Open Access Journals (Sweden)

    Femke van Nassau

    Full Text Available As the detrimental health effects of sedentary behaviour are well established, insight into the individual and environmental factors that influence adults' sedentary behaviour is needed. Most studies to date rely on self-reported measures of sedentary time. Therefore, the aim of the current study was to examine individual and environmental correlates of objectively measured sedentary time in Dutch and Belgian adults. Between March and August 2014, Belgian (n = 133 and Dutch (n = 223 adults, recruited as sub-sample of the SPOTLIGHT survey, wore an ActiGraph accelerometer to provide objectively measured sedentary and moderate to vigorous physical activity time. Participants completed a questionnaire assessing sociodemographic (country of residence, age, gender and educational level, lifestyle (sleep, smoking, sugar-containing beverage consumption, alcohol intake, health (body mass index, self-rated health, work (employment status and type of work, happiness, physical environmental (owning a car, number of screens, socioeconomic status and residential density and social environmental factors (social network, social cohesion. Univariate and multivariable regression analyses showed that Belgian participants had a lower odds of being sedentary for at least 9 hours per day compared to Dutch participants. Women, older participants and those meeting the WHO recommendation for physical activity were also less likely to sit for 9 hours or more per day. Participants doing (heavy manual work or being in education, homemaker, unemployed had lower odds of being sedentary for at least 9 hours per day compared to participants with a sitting job. Those with a higher self-reported social network also had lower odds for sedentary time. No associations between physical and other social environmental characteristics and sedentary time were found. Our findings add to the growing evidence of factors associated with prolonged sedentary time in adults. These findings may

  1. Determinants of Three-Year Change in Children's Objectively Measured Sedentary Time.

    Science.gov (United States)

    Atkin, Andrew J; Foley, Louise; Corder, Kirsten; Ekelund, Ulf; van Sluijs, Esther M F

    2016-01-01

    Sedentary behaviours (SB) are highly prevalent in young people and may be adversely associated with physical and mental health. Understanding of the modifiable determinants of SB is necessary to inform the design of behaviour change interventions but much of the existing research is cross-sectional and focussed upon screen-based behaviours. To examine the social, psychological and environmental determinants of change in children's objectively measured sedentary time from age 11 to 14 years. Data are from the second (2008) and third (2011) waves of assessment in the Sport, Physical Activity, and Eating Behaviour: Environmental Determinants in Young People (SPEEDY) study, conducted in the county of Norfolk, United Kingdom. Longitudinal data on accelerometer assessed sedentary time were available for 316 (53.5% female, 11.2±0.3 years at baseline) and 264 children after-school and at the weekend respectively. Information on 14 candidate determinants, including school travel mode and electronic media ownership, was self-reported. Change in the proportion of registered time spent sedentary was used as the outcome variable in cross-classified linear regression models, adjusted for age, sex, body mass index and baseline sedentary time. Simple and multiple models were run and interactions with sex explored. Daily sedentary time increased by 30-40 minutes after-school and at the weekend from baseline to follow-up. Participants who travelled to school by cycle exhibited smaller increases in after-school sedentary time (beta; 95%CI for change in % time spent sedentary: -3.3;-6.7,-0.07). No significant determinants of change in weekend sedentary time were identified. Time spent sedentary increased during the three-year duration of follow-up but few of the variables examined were significantly associated with changes in sedentary time. Children's mode of school travel may influence changes in their sedentary time over this period and should be examined further, alongside

  2. Real-Time Projection-Based Augmented Reality System for Dynamic Objects in the Performing Arts

    Directory of Open Access Journals (Sweden)

    Jaewoon Lee

    2015-02-01

    Full Text Available This paper describes the case study of applying projection-based augmented reality, especially for dynamic objects in live performing shows, such as plays, dancing, or musicals. Our study aims to project imagery correctly inside the silhouettes of flexible objects, in other words, live actors or the surface of actor’s costumes; the silhouette transforms its own shape frequently. To realize this work, we implemented a special projection system based on the real-time masking technique, that is to say real-time projection-based augmented reality system for dynamic objects in performing arts. We installed the sets on a stage for live performance, and rehearsed particular scenes of a musical. In live performance, using projection-based augmented reality technology enhances technical and theatrical aspects which were not possible with existing video projection techniques. The projected images on the surfaces of actor’s costume could not only express the particular scene of a performance more effectively, but also lead the audience to an extraordinary visual experience.

  3. Time-dependent bow shocks and the condensation structure of Herbig-Haro objects

    International Nuclear Information System (INIS)

    Raga, A.C.; Bohm, K.H.

    1987-01-01

    Some Herbig-Haro objects show a structure which appears to look like a bow shock, but also show a number of condensations superposed on this bow-shaped structure. In the case of HH 1 and HH 2 considerably different proper motions have been measured for the individual condensations. It is, however, very hard to explain why the condensations remain so close to each other if they are indeed separate entities. In this paper it is shown that an interpretation of the whole Herbig-Haro object as a single, time-dependent bow shock provides a natural explanation for the occurrence of condensations (which in numerical calculations appear to be associated with thermal instabilities in the postshock flow) with different proper motions. To this effect, time-dependent, axisymmetric, nonadiabatic bow shock models have been developed from which predictions were obtained for spatially resolved H-alpha intensity maps, and then these predictions are compared qualitatively with observations of a few Herbig-Haro objects. 57 references

  4. Deficits in Coordinative Bimanual Timing Precision in Children With Specific Language Impairment.

    Science.gov (United States)

    Vuolo, Janet; Goffman, Lisa; Zelaznik, Howard N

    2017-02-01

    Our objective was to delineate components of motor performance in specific language impairment (SLI); specifically, whether deficits in timing precision in one effector (unimanual tapping) and in two effectors (bimanual clapping) are observed in young children with SLI. Twenty-seven 4- to 5-year-old children with SLI and 21 age-matched peers with typical language development participated. All children engaged in a unimanual tapping and a bimanual clapping timing task. Standard measures of language and motor performance were also obtained. No group differences in timing variability were observed in the unimanual tapping task. However, compared with typically developing peers, children with SLI were more variable in their timing precision in the bimanual clapping task. Nine of the children with SLI performed greater than 1 SD below the mean on a standardized motor assessment. The children with low motor performance showed the same profile as observed across all children with SLI, with unaffected unimanual and impaired bimanual timing precision. Although unimanual timing is unaffected, children with SLI show a deficit in timing that requires bimanual coordination. We propose that the timing deficits observed in children with SLI are associated with the increased demands inherent in bimanual performance.

  5. Time integration and statistical regulation applied to mobile objects detection in a sequence of images

    International Nuclear Information System (INIS)

    Letang, Jean-Michel

    1993-01-01

    This PhD thesis deals with the detection of moving objects in monocular image sequences. The first section presents the inherent problems of motion analysis in real applications. We propose a method robust to perturbations frequently encountered during acquisition of outdoor scenes. It appears three main directions for investigations, all of them pointing out the importance of the temporal axis, which is a specific dimension for motion analysis. In the first part, the image sequence is considered as a set of temporal signals. The temporal multi-scale decomposition enables the characterization of various dynamical behaviors of the objects being in the scene at a given instant. A second module integrates motion information. This elementary trajectography of moving objects provides a temporal prediction map, giving a confidence level of motion presence. Interactions between both sets of data are expressed within a statistical regularization. Markov random field models supply a formal framework to convey a priori knowledge of the primitives to be evaluated. A calibration method with qualitative boxes is presented to estimate model parameters. Our approach requires only simple computations and leads to a rather fast algorithm, that we evaluate in the last section over various typical sequences. (author) [fr

  6. Subsurface Scattering-Based Object Rendering Techniques for Real-Time Smartphone Games

    Directory of Open Access Journals (Sweden)

    Won-Sun Lee

    2014-01-01

    Full Text Available Subsurface scattering that simulates the path of a light through the material in a scene is one of the advanced rendering techniques in the field of computer graphics society. Since it takes a number of long operations, it cannot be easily implemented in real-time smartphone games. In this paper, we propose a subsurface scattering-based object rendering technique that is optimized for smartphone games. We employ our subsurface scattering method that is utilized for a real-time smartphone game. And an example game is designed to validate how the proposed method can be operated seamlessly in real time. Finally, we show the comparison results between bidirectional reflectance distribution function, bidirectional scattering distribution function, and our proposed subsurface scattering method on a smartphone game.

  7. Planning GPS Measurements of a Linear Object for a Specified Time Interval

    Directory of Open Access Journals (Sweden)

    Specht Cezary

    2017-12-01

    Full Text Available The previous measurement campaigns planning used in geodesy is conducted exclusively for individual points. For the natural process aimed at the adoption of the introduction of the planning (prediction of constellation state in navigation, which is characterized by the movement, one should adopt measurement campaigns planning for linear objects. In contrast to the existing planning solutions, focused on point presentation of the state of the constellation of navigation system, the author of this article rearranges the proposal of determination of geometrical factors, and their summation. In the presented simulation, one has specified the route of passing at certain times and it was assumed that the receiver will move with variable motion. One has defined the geometric ratios (PDOP, which allow to distinguish the results corresponding to the adopted criteria for the measurement of linear object to be conducted with the best possible accuracy.

  8. Black objects and hoop conjecture in five-dimensional space-time

    Energy Technology Data Exchange (ETDEWEB)

    Yamada, Yuta; Shinkai, Hisa-aki, E-mail: m1m08a26@info.oit.ac.j, E-mail: shinkai@is.oit.ac.j [Faculty of Information Science and Technology, Osaka Institute of Technology, 1-79-1 Kitayama, Hirakata, Osaka 573-0196 (Japan)

    2010-02-21

    We numerically investigated the sequences of initial data of a thin spindle and a thin ring in five-dimensional space-time in the context of the cosmic censorship conjecture. We modeled the matter in non-rotating homogeneous spheroidal or toroidal configurations under the momentarily static assumption, solved the Hamiltonian constraint equation and searched the apparent horizons. We discussed when S{sup 3} (black-hole) or S{sup 1} x S{sup 2} (black-ring) horizons ('black objects') are formed. By monitoring the location of the maximum Kretchmann invariant, an appearance of 'naked singularity' or 'naked ring' under special situations is suggested. We also discuss the validity of the hyper-hoop conjecture using a minimum area around the object, and show that the appearance of the ring horizon does not match with this hoop.

  9. Objectively Measured Total and Occupational Sedentary Time in Three Work Settings

    Science.gov (United States)

    van Dommelen, Paula; Coffeng, Jennifer K.; van der Ploeg, Hidde P.; van der Beek, Allard J.; Boot, Cécile R. L.; Hendriksen, Ingrid J. M.

    2016-01-01

    Background Sedentary behaviour increases the risk for morbidity. Our primary aim is to determine the proportion and factors associated with objectively measured total and occupational sedentary time in three work settings. Secondary aim is to study the proportion of physical activity and prolonged sedentary bouts. Methods Data were obtained using ActiGraph accelerometers from employees of: 1) a financial service provider (n = 49 men, 31 women), 2) two research institutes (n = 30 men, 57 women), and 3) a construction company (n = 38 men). Total (over the whole day) and occupational sedentary time, physical activity and prolonged sedentary bouts (lasting ≥30 minutes) were calculated by work setting. Linear regression analyses were performed to examine general, health and work-related factors associated with sedentary time. Results The employees of the financial service provider and the research institutes spent 76–80% of their occupational time in sedentary behaviour, 18–20% in light intensity physical activity and 3–5% in moderate-to-vigorous intensity physical activity. Occupational time in prolonged sedentary bouts was 27–30%. Total time was less sedentary (64–70%), and had more light intensity physical activity (26–33%). The employees of the construction company spent 44% of their occupational time in sedentary behaviour, 49% in light, and 7% in moderate intensity physical activity, and spent 7% in sedentary bouts. Total time spent in sedentary behavior was 56%, 40% in light, and 4% in moderate intensity physical behaviour, and 12% in sedentary bouts. For women, low to intermediate education was the only factor that was negatively associated with occupational sedentary time. Conclusions Sedentary behaviour is high among white-collar employees, especially in highly educated women. A relatively small proportion of sedentary time was accrued in sedentary bouts. It is recommended that worksite health promotion efforts should focus on reducing sedentary

  10. Time-lapse videos for physics education: specific examples

    Science.gov (United States)

    Vollmer, Michael; Möllmann, Klaus-Peter

    2018-05-01

    There are many physics experiments with long time scales such that they are usually neither shown in the physics class room nor in student labs. However, they can be easily recorded with time-lapse cameras and the respective time-lapse videos allow qualitative and/or quantitative analysis of the underlying physics. Here, we present some examples from thermal physics (melting, evaporation, cooling) as well as diffusion processes

  11. Specific MRI quality control: development and production of a multimodal test-object. Assessment of MRI sequences

    International Nuclear Information System (INIS)

    Dedieu, Veronique; Bard, Jean-Jacques; Bonnet, Jacques; Buchheit, Isabelle; Confort-Gouny, Sylviane; Certaines, Jacques de; Lacaze, Brigitte; Vincensini, Dominique; Joffre, Francis

    2007-02-01

    After a first part recalling the operation principle of a MRI imager and the modalities of acquisition of MRI images (base MNR experiment, image quality, technical issues, artefacts and main defects of MRI imagers), this document addresses the different types of quality control in MRI and regulatory issues. The third part presents the characteristics of a multimodal test-object which has been developed, the parameters of the specific quality control, and control procedures

  12. Associations of office workers' objectively assessed occupational sitting, standing and stepping time with musculoskeletal symptoms.

    Science.gov (United States)

    Coenen, Pieter; Healy, Genevieve N; Winkler, Elisabeth A H; Dunstan, David W; Owen, Neville; Moodie, Marj; LaMontagne, Anthony D; Eakin, Elizabeth A; O'Sullivan, Peter B; Straker, Leon M

    2018-04-22

    We examined the association of musculoskeletal symptoms (MSS) with workplace sitting, standing and stepping time, as well as sitting and standing time accumulation (i.e. usual bout duration of these activities), measured objectively with the activPAL3 monitor. Using baseline data from the Stand Up Victoria trial (216 office workers, 14 workplaces), cross-sectional associations of occupational activities with self-reported MSS (low-back, upper and lower extremity symptoms in the last three months) were examined using probit regression, correcting for clustering and adjusting for confounders. Sitting bout duration was significantly (p < 0.05) associated, non-linearly, with MSS, such that those in the middle tertile displayed the highest prevalence of upper extremity symptoms. Other associations were non-significant but sometimes involved large differences in symptom prevalence (e.g. 38%) by activity. Though causation is unclear, these non-linear associations suggest that sitting and its alternatives (i.e. standing and stepping) interact with MSS and this should be considered when designing safe work systems. Practitioner summary: We studied associations of objectively assessed occupational activities with musculoskeletal symptoms in office workers. Workers who accumulated longer sitting bouts reported fewer upper extremity symptoms. Total activity duration was not significantly associated with musculoskeletal symptoms. We underline the importance of considering total volumes and patterns of activity time in musculoskeletal research.

  13. Real-time, resource-constrained object classification on a micro-air vehicle

    Science.gov (United States)

    Buck, Louis; Ray, Laura

    2013-12-01

    A real-time embedded object classification algorithm is developed through the novel combination of binary feature descriptors, a bag-of-visual-words object model and the cortico-striatal loop (CSL) learning algorithm. The BRIEF, ORB and FREAK binary descriptors are tested and compared to SIFT descriptors with regard to their respective classification accuracies, execution times, and memory requirements when used with CSL on a 12.6 g ARM Cortex embedded processor running at 800 MHz. Additionally, the effect of x2 feature mapping and opponent-color representations used with these descriptors is examined. These tests are performed on four data sets of varying sizes and difficulty, and the BRIEF descriptor is found to yield the best combination of speed and classification accuracy. Its use with CSL achieves accuracies between 67% and 95% of those achieved with SIFT descriptors and allows for the embedded classification of a 128x192 pixel image in 0.15 seconds, 60 times faster than classification with SIFT. X2 mapping is found to provide substantial improvements in classification accuracy for all of the descriptors at little cost, while opponent-color descriptors are offer accuracy improvements only on colorful datasets.

  14. Objectively measured sedentary time and physical activity in women with fibromyalgia: a cross-sectional study.

    Science.gov (United States)

    Ruiz, Jonatan R; Segura-Jiménez, Víctor; Ortega, Francisco B; Alvarez-Gallardo, Inmaculada C; Camiletti-Moirón, Daniel; Aparicio, Virginia A; Carbonell-Baeza, Ana; Femia, Pedro; Munguía-Izquierdo, Diego; Delgado-Fernández, Manuel

    2013-06-20

    To characterise levels of objectively measured sedentary time and physical activity in women with fibromyalgia. Cross-sectional study. Local Association of Fibromyalgia (Granada, Spain). The study comprised 94 women with diagnosed fibromyalgia who did not have other severe somatic or psychiatric disorders, or other diseases that prevent physical loading, able to ambulate and to communicate and capable and willing to provide informed consent. Sedentary time and physical activity were measured by accelerometry and expressed as time spent in sedentary behaviours, average physical activity intensity (counts/minute) and amount of time (minutes/day) spent in moderate intensity and in moderate-to-vigorous-intensity physical activity (MVPA). The proportion of women meeting the physical activity recommendations of 30 min/day of MVPA on 5 or more days a week was 60.6%. Women spent, on average, 71% of their waking time (approximately 10 h/day) in sedentary behaviours. Both sedentary behaviour and physical activity levels were similar across age groups, waist circumference and percentage body fat categories, years since clinical diagnosis, marital status, educational level and occupational status, regardless of the severity of the disease (all p>0.1). Time spent on moderate-intensity physical activity and MVPA was, however, lower in those with greater body mass index (BMI) (-6.6 min and -7 min, respectively, per BMI category increase, 30 kg/m(2); p values for trend were 0.056 and 0.051, respectively). Women spent, on average, 10 min less on MVPA (pfibromyalgia.

  15. Objectively-determined intensity- and domain-specific physical activity and sedentary behavior in relation to percent body fat.

    Science.gov (United States)

    Scheers, Tineke; Philippaerts, Renaat; Lefevre, Johan

    2013-12-01

    This study examined the independent and joint associations of overall, intensity-specific and domain-specific physical activity and sedentary behavior with bioelectrical impedance-determined percent body fat. Physical activity was measured in 442 Flemish adults (41.4 ± 9.8 years) using the SenseWear Armband and an electronic diary. Two-way analyses of covariance investigated the interaction of physical activity and sedentary behavior with percent body fat. Multiple linear regression analyses, adjusted for potential confounders, examined the associations of intensity-specific and domain-specific physical activity and sedentary behavior with percent body fat. Results showed a significant main effect for physical activity in both genders and for sedentary behavior in women, but no interaction effects. Light activity was positively (β = 0.41 for men and 0.43 for women) and moderate (β = -0.64 and -0.41), vigorous (β = -0.21 and -0.24) and moderate-to-vigorous physical activity (MVPA) inversely associated with percent body fat, independent of sedentary time. Regarding domain-specific physical activity, significant associations were present for occupation, leisure time and household chores, irrespective of sedentary time. The positive associations between body fat and total and domain-specific sedentary behavior diminished after MVPA was controlled for. MVPA during leisure time, occupation and household chores may be essential to prevent fat gain. Copyright © 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  16. Measuring time and risk preferences: Reliability, stability, domain specificity

    NARCIS (Netherlands)

    Wölbert, E.M.; Riedl, A.M.

    2013-01-01

    To accurately predict behavior economists need reliable measures of individual time preferences and attitudes toward risk and typically need to assume stability of these characteristics over time and across decision domains. We test the reliability of two choice tasks for eliciting discount rates,

  17. Sequential specification of time-aware stream processing applications

    NARCIS (Netherlands)

    Geuns, S.J.; Hausmans, J.P.H.M.; Bekooij, Marco Jan Gerrit

    Automatic parallelization of Nested Loop Programs (NLPs) is an attractive method to create embedded real-time stream processing applications for multi-core systems. However, the description and parallelization of applications with a time dependent functional behavior has not been considered in NLPs.

  18. Adolescents' technology and face-to-face time use predict objective sleep outcomes.

    Science.gov (United States)

    Tavernier, Royette; Heissel, Jennifer A; Sladek, Michael R; Grant, Kathryn E; Adam, Emma K

    2017-08-01

    The present study examined both within- and between-person associations between adolescents' time use (technology-based activities and face-to-face interactions with friends and family) and sleep behaviors. We also assessed whether age moderated associations between adolescents' time use with friends and family and sleep. Adolescents wore an actigraph monitor and completed brief evening surveys daily for 3 consecutive days. Adolescents (N=71; mean age=14.50 years old, SD=1.84; 43.7% female) were recruited from 3 public high schools in the Midwest. We assessed 8 technology-based activities (eg, texting, working on a computer), as well as time spent engaged in face-to-face interactions with friends and family, via questions on adolescents' evening surveys. Actigraph monitors assessed 3 sleep behaviors: sleep latency, sleep hours, and sleep efficiency. Hierarchical linear models indicated that texting and working on the computer were associated with shorter sleep, whereas time spent talking on the phone predicted longer sleep. Time spent with friends predicted shorter sleep latencies, while family time predicted longer sleep latencies. Age moderated the association between time spent with friends and sleep efficiency, as well as between family time and sleep efficiency. Specifically, longer time spent interacting with friends was associated with higher sleep efficiency but only among younger adolescents. Furthermore, longer family time was associated with higher sleep efficiency but only for older adolescents. Findings are discussed in terms of the importance of regulating adolescents' technology use and improving opportunities for face-to-face interactions with friends, particularly for younger adolescents. Copyright © 2017 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.

  19. Time-domain single-source integral equations for analyzing scattering from homogeneous penetrable objects

    KAUST Repository

    Valdés, Felipe

    2013-03-01

    Single-source time-domain electric-and magnetic-field integral equations for analyzing scattering from homogeneous penetrable objects are presented. Their temporal discretization is effected by using shifted piecewise polynomial temporal basis functions and a collocation testing procedure, thus allowing for a marching-on-in-time (MOT) solution scheme. Unlike dual-source formulations, single-source equations involve space-time domain operator products, for which spatial discretization techniques developed for standalone operators do not apply. Here, the spatial discretization of the single-source time-domain integral equations is achieved by using the high-order divergence-conforming basis functions developed by Graglia alongside the high-order divergence-and quasi curl-conforming (DQCC) basis functions of Valdés The combination of these two sets allows for a well-conditioned mapping from div-to curl-conforming function spaces that fully respects the space-mapping properties of the space-time operators involved. Numerical results corroborate the fact that the proposed procedure guarantees accuracy and stability of the MOT scheme. © 2012 IEEE.

  20. Experimental Evaluation of Processing Time for the Synchronization of XML-Based Business Objects

    Science.gov (United States)

    Ameling, Michael; Wolf, Bernhard; Springer, Thomas; Schill, Alexander

    Business objects (BOs) are data containers for complex data structures used in business applications such as Supply Chain Management and Customer Relationship Management. Due to the replication of application logic, multiple copies of BOs are created which have to be synchronized and updated. This is a complex and time consuming task because BOs rigorously vary in their structure according to the distribution, number and size of elements. Since BOs are internally represented as XML documents, the parsing of XML is one major cost factor which has to be considered for minimizing the processing time during synchronization. The prediction of the parsing time for BOs is an significant property for the selection of an efficient synchronization mechanism. In this paper, we present a method to evaluate the influence of the structure of BOs on their parsing time. The results of our experimental evaluation incorporating four different XML parsers examine the dependencies between the distribution of elements and the parsing time. Finally, a general cost model will be validated and simplified according to the results of the experimental setup.

  1. Cross-Sectional Analysis of Levels and Patterns of Objectively Measured Sedentary Time in Adolescent Females

    LENUS (Irish Health Repository)

    Harrington, Deirdre M.

    2011-10-28

    Abstract Background Adolescent females have been highlighted as a particularly sedentary population and the possible negative effects of a sedentary lifestyle are being uncovered. However, much of the past sedentary research is based on self-report or uses indirect methods to quantity sedentary time. Total time spent sedentary and the possible intricate sedentary patterns of adolescent females have not been described using objective and direct measure of body inclination. The objectives of this article are to examine the sedentary levels and patterns of a group of adolescent females using the ActivPAL™ and to highlight possible differences in sedentary levels and patterns across the week and within the school day. A full methodological description of how the data was analyzed is also presented. Methods One hundred and eleven adolescent females, age 15-18 yrs, were recruited from urban and rural areas in the Republic of Ireland. Participants wore an ActivPAL physical activity monitor for a 7.5 day period. The ActivPAL directly reports total time spent sitting\\/lying every 15 seconds and accumulation (frequency and duration) of sedentary activity was examined using a customized MATLAB ® computer software programme. Results While no significant difference was found in the total time spent sitting\\/lying over the full 24 hour day between weekday and weekend day (18.8 vs. 18.9 hours; p = .911), significantly more sedentary bouts of 1 to 5 minutes and 21 to 40 minutes in duration were accumulated on weekdays compared to weekend days (p < .001). The mean length of each sedentary bout was also longer (9.8 vs. 8.8 minutes; p < .001). When school hours (9 am-3 pm) and after school hours (4 pm-10 pm) were compared, there was no difference in total time spent sedentary (3.9 hours; p = .796) but the pattern of accumulation of the sedentary time differed. There were a greater number of bouts of > 20 minutes duration during school hours than after school hours (4.7 vs. 3

  2. Time domain SAR raw data simulation using CST and image focusing of 3D objects

    Science.gov (United States)

    Saeed, Adnan; Hellwich, Olaf

    2017-10-01

    This paper presents the use of a general purpose electromagnetic simulator, CST, to simulate realistic synthetic aperture radar (SAR) raw data of three-dimensional objects. Raw data is later focused in MATLAB using range-doppler algorithm. Within CST Microwave Studio a replica of TerraSAR-X chirp signal is incident upon a modeled Corner Reflector (CR) whose design and material properties are identical to that of the real one. Defining mesh and other appropriate settings reflected wave is measured at several distant points within a line parallel to the viewing direction. This is analogous to an array antenna and is synthesized to create a long aperture for SAR processing. The time domain solver in CST is based on the solution of differential form of Maxwells equations. Exported data from CST is arranged into a 2-d matrix of axis range and azimuth. Hilbert transform is applied to convert the real signal to complex data with phase information. Range compression, range cell migration correction (RCMC), and azimuth compression are applied in time domain to obtain the final SAR image. This simulation can provide valuable information to clarify which real world objects cause images suitable for high accuracy identification in the SAR images.

  3. Real-time multiple objects tracking on Raspberry-Pi-based smart embedded camera

    Science.gov (United States)

    Dziri, Aziz; Duranton, Marc; Chapuis, Roland

    2016-07-01

    Multiple-object tracking constitutes a major step in several computer vision applications, such as surveillance, advanced driver assistance systems, and automatic traffic monitoring. Because of the number of cameras used to cover a large area, these applications are constrained by the cost of each node, the power consumption, the robustness of the tracking, the processing time, and the ease of deployment of the system. To meet these challenges, the use of low-power and low-cost embedded vision platforms to achieve reliable tracking becomes essential in networks of cameras. We propose a tracking pipeline that is designed for fixed smart cameras and which can handle occlusions between objects. We show that the proposed pipeline reaches real-time processing on a low-cost embedded smart camera composed of a Raspberry-Pi board and a RaspiCam camera. The tracking quality and the processing speed obtained with the proposed pipeline are evaluated on publicly available datasets and compared to the state-of-the-art methods.

  4. Frictional Heating with Time-Dependent Specific Power of Friction

    Directory of Open Access Journals (Sweden)

    Topczewska Katarzyna

    2017-06-01

    Full Text Available In this paper analytical solutions of the thermal problems of friction were received. The appropriate boundary-value problems of heat conduction were formulated and solved for a homogeneous semi–space (a brake disc heated on its free surface by frictional heat fluxes with different and time-dependent intensities. Solutions were obtained in dimensionless form using Duhamel's theorem. Based on received solutions, evolution and spatial distribution of the dimensionless temperature were analyzed using numerical methods. The numerical results allowed to determine influence of the time distribution of friction power on the spatio-temporal temperature distribution in brake disc.

  5. Determinants of Three-Year Change in Children’s Objectively Measured Sedentary Time

    Science.gov (United States)

    Foley, Louise; Corder, Kirsten; Ekelund, Ulf; van Sluijs, Esther M. F.

    2016-01-01

    Background Sedentary behaviours (SB) are highly prevalent in young people and may be adversely associated with physical and mental health. Understanding of the modifiable determinants of SB is necessary to inform the design of behaviour change interventions but much of the existing research is cross-sectional and focussed upon screen-based behaviours. Purpose To examine the social, psychological and environmental determinants of change in children’s objectively measured sedentary time from age 11 to 14 years. Methods Data are from the second (2008) and third (2011) waves of assessment in the Sport, Physical Activity, and Eating Behaviour: Environmental Determinants in Young People (SPEEDY) study, conducted in the county of Norfolk, United Kingdom. Longitudinal data on accelerometer assessed sedentary time were available for 316 (53.5% female, 11.2±0.3 years at baseline) and 264 children after-school and at the weekend respectively. Information on 14 candidate determinants, including school travel mode and electronic media ownership, was self-reported. Change in the proportion of registered time spent sedentary was used as the outcome variable in cross-classified linear regression models, adjusted for age, sex, body mass index and baseline sedentary time. Simple and multiple models were run and interactions with sex explored. Results Daily sedentary time increased by 30–40 minutes after-school and at the weekend from baseline to follow-up. Participants who travelled to school by cycle exhibited smaller increases in after-school sedentary time (beta; 95%CI for change in % time spent sedentary: -3.3;-6.7,-0.07). No significant determinants of change in weekend sedentary time were identified. Conclusions Time spent sedentary increased during the three-year duration of follow-up but few of the variables examined were significantly associated with changes in sedentary time. Children’s mode of school travel may influence changes in their sedentary time over this

  6. Determinants of Three-Year Change in Children's Objectively Measured Sedentary Time.

    Directory of Open Access Journals (Sweden)

    Andrew J Atkin

    Full Text Available Sedentary behaviours (SB are highly prevalent in young people and may be adversely associated with physical and mental health. Understanding of the modifiable determinants of SB is necessary to inform the design of behaviour change interventions but much of the existing research is cross-sectional and focussed upon screen-based behaviours.To examine the social, psychological and environmental determinants of change in children's objectively measured sedentary time from age 11 to 14 years.Data are from the second (2008 and third (2011 waves of assessment in the Sport, Physical Activity, and Eating Behaviour: Environmental Determinants in Young People (SPEEDY study, conducted in the county of Norfolk, United Kingdom. Longitudinal data on accelerometer assessed sedentary time were available for 316 (53.5% female, 11.2±0.3 years at baseline and 264 children after-school and at the weekend respectively. Information on 14 candidate determinants, including school travel mode and electronic media ownership, was self-reported. Change in the proportion of registered time spent sedentary was used as the outcome variable in cross-classified linear regression models, adjusted for age, sex, body mass index and baseline sedentary time. Simple and multiple models were run and interactions with sex explored.Daily sedentary time increased by 30-40 minutes after-school and at the weekend from baseline to follow-up. Participants who travelled to school by cycle exhibited smaller increases in after-school sedentary time (beta; 95%CI for change in % time spent sedentary: -3.3;-6.7,-0.07. No significant determinants of change in weekend sedentary time were identified.Time spent sedentary increased during the three-year duration of follow-up but few of the variables examined were significantly associated with changes in sedentary time. Children's mode of school travel may influence changes in their sedentary time over this period and should be examined further

  7. Aversive olfactory associative memory loses odor specificity over time.

    Science.gov (United States)

    König, Christian; Antwi-Adjei, Emmanuel; Ganesan, Mathangi; Kilonzo, Kasyoka; Viswanathan, Vignesh; Durairaja, Archana; Voigt, Anne; Yarali, Ayse

    2017-05-01

    Avoiding associatively learned predictors of danger is crucial for survival. Aversive memories can, however, become counter-adaptive when they are overly generalized to harmless cues and contexts. In a fruit fly odor-electric shock associative memory paradigm, we found that learned avoidance lost its specificity for the trained odor and became general to novel odors within a day of training. We discuss the possible neural circuit mechanisms of this effect and highlight the parallelism to over-generalization of learned fear behavior after an incubation period in rodents and humans, with due relevance for post-traumatic stress disorder. © 2017. Published by The Company of Biologists Ltd.

  8. Time for a neonatal-specific consensus definition for sepsis.

    Science.gov (United States)

    Wynn, James L; Wong, Hector R; Shanley, Thomas P; Bizzarro, Matthew J; Saiman, Lisa; Polin, Richard A

    2014-07-01

    To review the accuracy of the pediatric consensus definition of sepsis in term neonates and to determine the definition of neonatal sepsis used. The review focused primarily on pediatric literature relevant to the topic of interest. Neonatal sepsis is variably defined based on a number of clinical and laboratory criteria that make the study of this common and devastating condition very difficult. Diagnostic challenges and uncertain disease epidemiology necessarily result from a variable definition of disease. In 2005, intensivists caring for children recognized that as new drugs became available, children would be increasingly studied and thus, pediatric-specific consensus definitions were needed. Pediatric sepsis criteria are not accurate for term neonates and have not been examined in preterm neonates for whom the developmental stage influences aberrations associated with host immune response. Thus, specific consensus definitions for both term and preterm neonates are needed. Such definitions are critical for the interpretation of observational studies, future training of scientists and practitioners, and implementation of clinical trials in neonates.

  9. Objectively Measured Physical Activity and Sedentary Time during Childhood, Adolescence and Young Adulthood: A Cohort Study

    Science.gov (United States)

    Ortega, Francisco B.; Hurtig-Wennlöf, Anita; Mäestu, Jarek; Löf, Marie; Harro, Jaanus; Bellocco, Rino; Labayen, Idoia; Veidebaum, Toomas; Sjöström, Michael

    2013-01-01

    Background To know how moderate-to-vigorous physical activity (MVPA) and sedentary time change across lifespan periods is needed for designing successful lifestyle interventions. We aimed to study changes in objectively measured (accelerometry) MVPA and sedentary time from childhood to adolescence and from adolescence to young adulthood. Methods Estonian and Swedish participants from the European Youth Heart Study aged 9 and 15 years at baseline (N = 2312) were asked to participate in a second examination 6 (Sweden) to 9/10 (Estonia) years later. 1800 participants with valid accelerometer data were analyzed. Results MVPA decreased from childhood to adolescence (−1 to −2.5 min/d per year of follow-up, P = 0.01 and girls and boys respectively) and also from adolescence to young adulthood (−0.8 to −2.2 min/d per year, P = 0.02 and girls and boys, respectively). Sedentary time increased from childhood to adolescence (+15 and +20 min/d per year, for girls and boys respectively, Pboys than in girls. The magnitude of the change observed in sedentary time was 3–6 time larger than the change observed in MVPA. Conclusions The decline in MVPA (overall change = 30 min/d) and increase sedentary time (overall change = 2∶45 h/d) observed from childhood to adolescence are of concern and might increase the risk of developing obesity and other chronic diseases later in life. These findings substantially contribute to understand how key health-related behaviors (physical activity and sedentary) change across important periods of life. PMID:23637772

  10. A Time to Define: Making the Specific Learning Disability Definition Prescribe Specific Learning Disability

    Science.gov (United States)

    Kavale, Kenneth A.; Spaulding, Lucinda S.; Beam, Andrea P.

    2009-01-01

    Unlike other special education categories defined in U.S. law (Individuals with Disabilities Education Act), the definition of specific learning disability (SLD) has not changed since first proposed in 1968. Thus, although the operational definition of SLD has responded to new knowledge and understanding about the construct, the formal definition…

  11. Parameter Estimation of a Delay Time Model of Wearing Parts Based on Objective Data

    Directory of Open Access Journals (Sweden)

    Y. Tang

    2015-01-01

    Full Text Available The wearing parts of a system have a very high failure frequency, making it necessary to carry out continual functional inspections and maintenance to protect the system from unscheduled downtime. This allows for the collection of a large amount of maintenance data. Taking the unique characteristics of the wearing parts into consideration, we establish their respective delay time models in ideal inspection cases and nonideal inspection cases. The model parameters are estimated entirely using the collected maintenance data. Then, a likelihood function of all renewal events is derived based on their occurring probability functions, and the model parameters are calculated with the maximum likelihood function method, which is solved by the CRM. Finally, using two wearing parts from the oil and gas drilling industry as examples—the filter element and the blowout preventer rubber core—the parameters of the distribution function of the initial failure time and the delay time for each example are estimated, and their distribution functions are obtained. Such parameter estimation based on objective data will contribute to the optimization of the reasonable function inspection interval and will also provide some theoretical models to support the integrity management of equipment or systems.

  12. Real-time object tracking based on scale-invariant features employing bio-inspired hardware.

    Science.gov (United States)

    Yasukawa, Shinsuke; Okuno, Hirotsugu; Ishii, Kazuo; Yagi, Tetsuya

    2016-09-01

    We developed a vision sensor system that performs a scale-invariant feature transform (SIFT) in real time. To apply the SIFT algorithm efficiently, we focus on a two-fold process performed by the visual system: whole-image parallel filtering and frequency-band parallel processing. The vision sensor system comprises an active pixel sensor, a metal-oxide semiconductor (MOS)-based resistive network, a field-programmable gate array (FPGA), and a digital computer. We employed the MOS-based resistive network for instantaneous spatial filtering and a configurable filter size. The FPGA is used to pipeline process the frequency-band signals. The proposed system was evaluated by tracking the feature points detected on an object in a video. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Guidance For The Proper Characterization And Classification Of Low Specific Activity Materials And Surface Contaminated Objects For Disposal

    International Nuclear Information System (INIS)

    Portsmouth, J.H.; Blackford, L.T.

    2012-01-01

    Regulatory concerns over the proper characterization of certain waste streams led CH2M HILL Plateau Remediation Company (CHPRC) to develop written guidance for personnel involved in Decontamination and Decommissioning (D and D) activities, facility management and Waste Management Representatives (WMRs) involved in the designation of wastes for disposal on and off the Hanford Site. It is essential that these waste streams regularly encountered in D and D operations are properly designated, characterized and classified prior to shipment to a Treatment, Storage or Disposal Facility (TSDF). Shipments of waste determined by the classification process as Low Specific Activity (LSA) or Surface Contaminated Objects (SCO) must also be compliant with all applicable U.S. Department of Transportation (DOE) regulations as well as Department of Energy (DOE) orders. The compliant shipment of these waste commodities is critical to the Hanford Central Plateau cleanup mission. Due to previous problems and concerns from DOE assessments, CHPRC internal critiques as well as DOT, a management decision was made to develop written guidance and procedures to assist CHPRC shippers and facility personnel in the proper classification of D and D waste materials as either LSA or SCO. The guidance provides a uniform methodology for the collection and documentation required to effectively characterize, classify and identify candidate materials for shipping operations. A primary focus is to ensure that waste materials generated from D and D and facility operations are compliant with the DOT regulations when packaged for shipment. At times this can be difficult as the current DOT regulations relative to the shipment of LSA and SCO materials are often not clear to waste generators. Guidance is often sought from NUREG 1608/RAMREG-003 (3): a guidance document that was jointly developed by the DOT and the Nuclear Regulatory Commission (NRC) and published in 1998. However, NUREG 1608 (3) is now thirteen

  14. Computational issues in complex water-energy optimization problems: Time scales, parameterizations, objectives and algorithms

    Science.gov (United States)

    Efstratiadis, Andreas; Tsoukalas, Ioannis; Kossieris, Panayiotis; Karavokiros, George; Christofides, Antonis; Siskos, Alexandros; Mamassis, Nikos; Koutsoyiannis, Demetris

    2015-04-01

    Modelling of large-scale hybrid renewable energy systems (HRES) is a challenging task, for which several open computational issues exist. HRES comprise typical components of hydrosystems (reservoirs, boreholes, conveyance networks, hydropower stations, pumps, water demand nodes, etc.), which are dynamically linked with renewables (e.g., wind turbines, solar parks) and energy demand nodes. In such systems, apart from the well-known shortcomings of water resources modelling (nonlinear dynamics, unknown future inflows, large number of variables and constraints, conflicting criteria, etc.), additional complexities and uncertainties arise due to the introduction of energy components and associated fluxes. A major difficulty is the need for coupling two different temporal scales, given that in hydrosystem modeling, monthly simulation steps are typically adopted, yet for a faithful representation of the energy balance (i.e. energy production vs. demand) a much finer resolution (e.g. hourly) is required. Another drawback is the increase of control variables, constraints and objectives, due to the simultaneous modelling of the two parallel fluxes (i.e. water and energy) and their interactions. Finally, since the driving hydrometeorological processes of the integrated system are inherently uncertain, it is often essential to use synthetically generated input time series of large length, in order to assess the system performance in terms of reliability and risk, with satisfactory accuracy. To address these issues, we propose an effective and efficient modeling framework, key objectives of which are: (a) the substantial reduction of control variables, through parsimonious yet consistent parameterizations; (b) the substantial decrease of computational burden of simulation, by linearizing the combined water and energy allocation problem of each individual time step, and solve each local sub-problem through very fast linear network programming algorithms, and (c) the substantial

  15. Time-trends in method-specific suicide rates compared with the availability of specific compounds

    DEFF Research Database (Denmark)

    Nordentoft, Merete; Qin, Ping; Helweg-Larsen, Karin

    2006-01-01

    Restriction of means for suicide is an important part of suicide preventive strategies in different countries. All suicides in Denmark between 1970 and 2000 were examined with regard to method used for suicide. Overall suicide mortality and method-specific suicide mortality was compared...... in the number of suicides by self-poisoning with these compounds. Restricted access occurred concomittantly with a 55% decrease in suicide rate....

  16. Optimisation of chromatographic resolution using objective functions including both time and spectral information.

    Science.gov (United States)

    Torres-Lapasió, J R; Pous-Torres, S; Ortiz-Bolsico, C; García-Alvarez-Coque, M C

    2015-01-16

    The optimisation of the resolution in high-performance liquid chromatography is traditionally performed attending only to the time information. However, even in the optimal conditions, some peak pairs may remain unresolved. Such incomplete resolution can be still accomplished by deconvolution, which can be carried out with more guarantees of success by including spectral information. In this work, two-way chromatographic objective functions (COFs) that incorporate both time and spectral information were tested, based on the peak purity (analyte peak fraction free of overlapping) and the multivariate selectivity (figure of merit derived from the net analyte signal) concepts. These COFs are sensitive to situations where the components that coelute in a mixture show some spectral differences. Therefore, they are useful to find out experimental conditions where the spectrochromatograms can be recovered by deconvolution. Two-way multivariate selectivity yielded the best performance and was applied to the separation using diode-array detection of a mixture of 25 phenolic compounds, which remained unresolved in the chromatographic order using linear and multi-linear gradients of acetonitrile-water. Peak deconvolution was carried out using the combination of orthogonal projection approach and alternating least squares. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. Improving the Multi-Objective Performance of Rainwater Harvesting Systems Using Real-Time Control Technology

    Directory of Open Access Journals (Sweden)

    Wei D. Xu

    2018-02-01

    Full Text Available Many studies have identified the potential of rainwater harvesting (RWH systems to simultaneously augment potable water supply and reduce delivery of uncontrolled stormwater flows to downstream drainage networks. Potentially, such systems could also play a role in the controlled delivery of water to urban streams in ways which mimic baseflows. The performance of RWH systems to achieve these three objectives could be enhanced using Real-Time Control (RTC technology to receive rainfall forecasts and initiate pre-storm release in real time, although few studies have explored such potential. We used continuous simulation to model the ability of a range of allotment-scale RWH systems to simultaneously deliver: (i water supply; (ii stormwater retention; and (iii baseflow restoration. We compared the performance of RWH systems with RTC technology to conventional RWH systems and also systems designed with a passive baseflow release, rather than the active (RTC configuration. We found that RWH systems employing RTC technology were generally superior in simultaneously achieving water supply, stormwater retention and baseflow restoration benefits compared with the other types of system tested. The active operation provided by RTC allows the system to perform optimally across a wider range of climatic conditions, but needs to be carefully designed. We conclude that the active release mechanism employing RTC technology exhibits great promise; its ability to provide centralised control and failure detection also opens the possibility of delivering a more reliable rainwater harvesting system, which can be readily adapted to varying climate over both the short and long term.

  18. No Evidence for Phase-Specific Effects of 40 Hz HD–tACS on Multiple Object Tracking

    Directory of Open Access Journals (Sweden)

    Nicholas S. Bland

    2018-03-01

    Full Text Available Phase synchronization drives connectivity between neural oscillators, providing a flexible mechanism through which information can be effectively and selectively routed between task-relevant cortical areas. The ability to keep track of objects moving between the left and right visual hemifields, for example, requires the integration of information between the two cerebral hemispheres. Both animal and human studies have suggested that coherent (or phase-locked gamma oscillations (30–80 Hz might underlie this ability. While most human evidence has been strictly correlational, high-density transcranial alternating current stimulation (HD-tACS has been used to manipulate ongoing interhemispheric gamma phase relationships. Previous research showed that 40 Hz tACS delivered bilaterally over human motion complex could bias the perception of a bistable ambiguous motion stimulus (Helfrich et al., 2014. Specifically, this work showed that in-phase (0° offset stimulation boosted endogenous interhemispheric gamma coherence and biased perception toward the horizontal (whereby visual tokens moved between visual hemifields—requiring interhemispheric integration. By contrast, anti-phase (180° offset stimulation decreased interhemispheric gamma coherence and biased perception toward the vertical (whereby tokens moved within separate visual hemifields. Here we devised a multiple object tracking arena comprised of four quadrants whereby discrete objects moved either entirely within the left and right visual hemifields, or could cross freely between visual hemifields, thus requiring interhemispheric integration. Using the same HD-tACS montages as Helfrich et al. (2014, we found no phase-specific effect of 40 Hz stimulation on overall tracking performance. While tracking performance was generally lower during between-hemifield trials (presumably reflecting a cost of integration, this difference was unchanged by in- vs. anti-phase stimulation. Our null results

  19. Objectively measured physical activity and sedentary time in youth: the International children's accelerometry database (ICAD).

    Science.gov (United States)

    Cooper, Ashley R; Goodman, Anna; Page, Angie S; Sherar, Lauren B; Esliger, Dale W; van Sluijs, Esther M F; Andersen, Lars Bo; Anderssen, Sigmund; Cardon, Greet; Davey, Rachel; Froberg, Karsten; Hallal, Pedro; Janz, Kathleen F; Kordas, Katarzyna; Kreimler, Susi; Pate, Russ R; Puder, Jardena J; Reilly, John J; Salmon, Jo; Sardinha, Luis B; Timperio, Anna; Ekelund, Ulf

    2015-09-17

    Physical activity and sedentary behaviour in youth have been reported to vary by sex, age, weight status and country. However, supporting data are often self-reported and/or do not encompass a wide range of ages or geographical locations. This study aimed to describe objectively-measured physical activity and sedentary time patterns in youth. The International Children's Accelerometry Database (ICAD) consists of ActiGraph accelerometer data from 20 studies in ten countries, processed using common data reduction procedures. Analyses were conducted on 27,637 participants (2.8-18.4 years) who provided at least three days of valid accelerometer data. Linear regression was used to examine associations between age, sex, weight status, country and physical activity outcomes. Boys were less sedentary and more active than girls at all ages. After 5 years of age there was an average cross-sectional decrease of 4.2% in total physical activity with each additional year of age, due mainly to lower levels of light-intensity physical activity and greater time spent sedentary. Physical activity did not differ by weight status in the youngest children, but from age seven onwards, overweight/obese participants were less active than their normal weight counterparts. Physical activity varied between samples from different countries, with a 15-20% difference between the highest and lowest countries at age 9-10 and a 26-28% difference at age 12-13. Physical activity differed between samples from different countries, but the associations between demographic characteristics and physical activity were consistently observed. Further research is needed to explore environmental and sociocultural explanations for these differences.

  20. Multi-Objective Flexible Flow Shop Scheduling Problem Considering Variable Processing Time due to Renewable Energy

    Directory of Open Access Journals (Sweden)

    Xiuli Wu

    2018-03-01

    Full Text Available Renewable energy is an alternative to non-renewable energy to reduce the carbon footprint of manufacturing systems. Finding out how to make an alternative energy-efficient scheduling solution when renewable and non-renewable energy drives production is of great importance. In this paper, a multi-objective flexible flow shop scheduling problem that considers variable processing time due to renewable energy (MFFSP-VPTRE is studied. First, the optimization model of the MFFSP-VPTRE is formulated considering the periodicity of renewable energy and the limitations of energy storage capacity. Then, a hybrid non-dominated sorting genetic algorithm with variable local search (HNSGA-II is proposed to solve the MFFSP-VPTRE. An operation and machine-based encoding method is employed. A low-carbon scheduling algorithm is presented. Besides the crossover and mutation, a variable local search is used to improve the offspring’s Pareto set. The offspring and the parents are combined and those that dominate more are selected to continue evolving. Finally, two groups of experiments are carried out. The results show that the low-carbon scheduling algorithm can effectively reduce the carbon footprint under the premise of makespan optimization and the HNSGA-II outperforms the traditional NSGA-II and can solve the MFFSP-VPTRE effectively and efficiently.

  1. The production of direct object clitics in pre-school- and primary school-aged children with specific language impairments.

    Science.gov (United States)

    Guasti, Maria Teresa; Palma, Silvia; Genovese, Elisabetta; Stagi, Paolo; Saladini, Gabriella; Arosio, Fabrizio

    2016-01-01

    Third-person direct object (DO) clitic pronoun production is examined through an elicited production method in pre-school- and primary school-aged groups of Italian children with specific language impairment (SLI) to establish whether there is an improvement from age 5 years to age 7 years and whether there are qualitative differences in the two groups' responses. It was found that 5- and 7-year-old Italian children with SLI produce fewer third-person DO clitics than same-age peers. The kind of responses they provide changes: at 5 years, children with SLI tend to omit clitics, while at 7 years, they use a full noun. Production of third-person DO clitics is a persistent challenge for children with SLI and is confirmed to be a good clinical marker both at 5 and 7 years of age.

  2. Development of guidance on applications of regulatory requirements for low specific activity materials and surface contaminated objects

    International Nuclear Information System (INIS)

    Pope, R.B.; Easton, E.P.; Shankman, S.F.

    1997-01-01

    In 1985, the International Atomic Energy Agency issued revised regulations for the safe transport of radioactive material. Significant among the changes were major revisions to requirements for Low Specific Activity (LSA) material and Surface Contaminated Objects (SCOs). In preparation for the adoption of these requirements into regulations in the United States, it became apparent that guidance on how to apply these requirements, clarifying technical uncertainties and ensuring proper implementation, would be needed both by the regulators and those regulated. Thus, the US Department of Transportation and the US Nuclear Regulatory Commission, with the assistance of staff from Oak Ridge National Laboratory, are preparing regulatory guidance for LSA material and SCO transport. The guidance will present examples of acceptable methods for demonstrating compliance with the revised rules. Ideas being investigated for inclusion in the pending guidance are discussed in this paper. Under current plans, the guidance will be issued for public comment prior to final issuance of the guidance in 1997

  3. Development of guidance on applications of regulatory requirements for low specific activity materials and surface contaminated objects

    International Nuclear Information System (INIS)

    Pope, R.B.; Easton, E.P.; Shankman, S.F.; Boyle, R.W.

    1997-01-01

    In 1985, the International Atomic Energy Agency issued revised regulations for the safe transport of radioactive material. Significant among the changes were major revisions to requirements for Low Specific Activity (LSA) material and Surface Contaminated Objects (SCOs). In preparation for the adoption of these requirements into regulations in the United States, it became apparent that guidance on how to apply these requirements, clarifying technical uncertainties and ensuring proper implementation, would be needed both by the regulators and those regulated. Thus, the US Department of Transportation and the U.S. Nuclear Regulatory Commission, with the assistance of staff from Oak Ridge National Laboratory, are preparing regulatory guidance for LSA material and SCO transport. The guidance will present examples of acceptable methods for demonstrating compliance with the revised rules. Ideas being investigated for inclusion in the pending guidance are discussed in this paper. Under current plans, the guidance will be issued for public comment prior to final issue of the guidance in 1997. (Author)

  4. Comparative Evaluations of Four Specification Methods for Real-Time Systems

    Science.gov (United States)

    1989-12-01

    December 1989 Comparative Evaluations of Four Specification Methods for Real - Time Systems David P. Wood William G. Wood Specification and Design Methods...Methods for Real - Time Systems Abstract: A number of methods have been proposed in the last decade for the specification of system and software requirements...and software specification for real - time systems . Our process for the identification of methods that meet the above criteria is described in greater

  5. Modulation of neural activity during object naming: Effects of time and practice

    NARCIS (Netherlands)

    Turennout, M.I. van; Bielamowicz, L.; Martin, A.

    2003-01-01

    Repeated exposure to objects improves our ability to identify and name them, even after a long delay. Previous brain imaging studies have demonstrated that this experience-related facilitation of object naming is associated with neural changes in distinct brain regions. We used event-related

  6. RASW : a Run-time Adaptive Sliding Window to Improve Viola-Jones object detection.

    NARCIS (Netherlands)

    Comaschi, F.; Stuijk, S.; Basten, T.; Corporaal, H.

    2013-01-01

    Abstract—In recent years accurate algorithms for detecting objects in images have been developed. Among these algorithms, the object detection scheme proposed by Viola and Jones gained great popularity, especially after the release of high-quality face classifiers by the OpenCV group. However, as

  7. The role of space and time in object-based visual search

    NARCIS (Netherlands)

    Schreij, D.B.B.; Olivers, C.N.L.

    2013-01-01

    Recently we have provided evidence that observers more readily select a target from a visual search display if the motion trajectory of the display object suggests that the observer has dealt with it before. Here we test the prediction that this object-based memory effect on search breaks down if

  8. Application of the multi-objective cross-entropy method to the vehicle routing problem with soft time windows

    Directory of Open Access Journals (Sweden)

    C Hauman

    2014-06-01

    Full Text Available The vehicle routing problem with time windows is a widely studied problem with many real-world applications. The problem considered here entails the construction of routes that a number of identical vehicles travel to service different nodes within a certain time window. New benchmark problems with multi-objective features were recently suggested in the literature and the multi-objective optimisation cross-entropy method is applied to these problems to investigate the feasibility of the method and to determine and propose reference solutions for the benchmark problems. The application of the cross-entropy method to the multi-objective vehicle routing problem with soft time windows is investigated. The objectives that are evaluated include the minimisation of the total distance travelled, the number of vehicles and/or routes, the total waiting time and delay time of the vehicles and the makespan of a route.

  9. A reaction time advantage for calculating beliefs over public representations signals domain specificity for 'theory of mind'.

    Science.gov (United States)

    Cohen, Adam S; German, Tamsin C

    2010-06-01

    In a task where participants' overt task was to track the location of an object across a sequence of events, reaction times to unpredictable probes requiring an inference about a social agent's beliefs about the location of that object were obtained. Reaction times to false belief situations were faster than responses about the (false) contents of a map showing the location of the object (Experiment 1) and about the (false) direction of an arrow signaling the location of the object (Experiment 2). These results are consistent with developmental, neuro-imaging and neuropsychological evidence that there exist domain specific mechanisms within human cognition for encoding and reasoning about mental states. Specialization of these mechanisms may arise from either core cognitive architecture or via the accumulation of expertise in the social domain.

  10. DETERMINATION OF THE RESIDUAL OPERATING TIME OF UNRESTORABLE ELEMENT OF THE ELECTRIC POWER OBJECT AT THE WAYBALL DISTRIBUTION

    International Nuclear Information System (INIS)

    Namgaladze, D.; Gurgenidze, D.

    2007-01-01

    In practice, it is often essential to determinethe residual operating time for an unrestorable element of the electric power object which has operated without failure for a certain time. The density of probability distribution of operating time can be determined from the initial probability distribution of operating time. In this work, the relations for determination of the function of residual operating time of the unrestorable element at the exponential and Wayball distributions are analytically derived. (author)

  11. Patient-specific electric field simulations and acceleration measurements for objective analysis of intraoperative stimulation tests in the thalamus

    Directory of Open Access Journals (Sweden)

    Simone Hemm-Ode

    2016-11-01

    Full Text Available Despite an increasing use of deep brain stimulation (DBS the fundamental mechanisms of action remain largely unknown. Simulation of electric entities has previously been proposed for chronic DBS combined with subjective symptom evaluations, but not for intraoperative stimulation tests. The present paper introduces a method for an objective exploitation of intraoperative stimulation test data to identify the optimal implant position of the chronic DBS lead by relating the electric field simulations to the patient-specific anatomy and the clinical effects quantified by accelerometry. To illustrate the feasibility of this approach, it was applied to five patients with essential tremor bilaterally implanted in the ventral intermediate nucleus (VIM. The VIM and its neighborhood structures were preoperatively outlined in 3D on white matter attenuated inversion recovery MR images. Quantitative intraoperative clinical assessments were performed using accelerometry. Electric field simulations (n = 272 for intraoperative stimulation test data performed along two trajectories per side were set-up using the finite element method for 143 stimulation test positions. The resulting electric field isosurface of 0.2V/mm was superimposed to the outlined anatomical structures. The percentage of volume of each structure's overlap was calculated and related to the corresponding clinical improvement. The proposed concept has been successfully applied to the five patients. For higher clinical improvements, not only the VIM but as well other neighboring structures were covered by the electric field isosurfaces. The percentage of the volumes of the VIM, of the nucleus intermediate lateral of the thalamus and the prelemniscal radiations within the prerubral field of Forel increased for clinical improvements higher than 50% compared to improvements lower than 50%. The presented new concept allows a detailed and objective analysis of a high amount of intraoperative data to

  12. Time coordination of heterogeneous distance protections using a domain specific language

    Directory of Open Access Journals (Sweden)

    Marcin Kowalski

    2012-01-01

    Full Text Available BACKGROUND: Distance protections are widely used in protection of energy transmission lines, but their time coordination is still an important and difficult problem. Inappropriate configuration leads to a hazard event: remote circuit breaker tripping provided the local circuit breaker can be opened, which severely impairs power system operation.OBJECTIVE: To describe a method and provide software tools to alleviate the hazard in power systems.METHODS: A domain specific language (DSL for representation of a transmission line with its distance protection schema, and a translation algorithm from the DSL to probabilistic fault trees with time dependencies (PFTTDs are employed.RESULTS: The paper presents software tools that can support power protection experts in time coordination of distance protections. The tools are based upon abstract and concrete syntax of the DSL designed specifically for the purpose of the distance protection time coordination problem. In order to render creation of power line and its protection schema models easier, a DSL-dedicated editor supporting syntax and semantic aspects of the DSL has been developed. Additionally, a translator from the DSL into PFTTD language has been implemented.CONCLUSIONS: Power system experts are enabled to perform hazard probability assessment and sensitivity analysis.LIMITATIONS: Translation supports two types of distance protections, which are: single-system relays with starting elements as well as multi-system relays without starting elements. For the single-system relay, there is one timer per relay. For multi-system relays, there is one timer for each of possibly many protection zones. Other types of protections, e.g. overcurrent are not considered.

  13. Measuring Time in Sporting Competitions with the Domain-Specific Language EasyTime

    OpenAIRE

    Fister Jr., Iztok; Fister, Iztok

    2012-01-01

    Measuring time in mass sporting competitions is unthinkable manually today because of their long duration and unreliability. Besides, automatic timing devices based on the RFID technology have become cheaper. However, these devices cannot operate stand-alone. To work efficiently, they need a computer timing system for monitoring results. Such system should be capable of processing the incoming events, encoding and assigning results to a individual competitor, sorting results according to the ...

  14. Time course of spatial and feature selective attention for partly-occluded objects.

    Science.gov (United States)

    Kasai, Tetsuko; Takeya, Ryuji

    2012-07-01

    Attention selects objects/groups as the most fundamental units, and this may be achieved by an attention-spreading mechanism. Previous event-related potential (ERP) studies have found that attention-spreading is reflected by a decrease in the N1 spatial attention effect. The present study tested whether the electrophysiological attention effect is associated with the perception of object unity or amodal completion through the use of partly-occluded objects. ERPs were recorded in 14 participants who were required to pay attention to their left or right visual field and to press a button for a target shape in the attended field. Bilateral stimuli were presented rapidly, and were separated, connected, or connected behind an occluder. Behavioral performance in the connected and occluded conditions was worse than that in the separated condition, indicating that attention spread over perceptual object representations after amodal completion. Consistently, the late N1 spatial attention effect (180-220 ms post-stimulus) and the early phase (230-280 ms) of feature selection effects (target N2) at contralateral sites decreased, equally for the occluded and connected conditions, while the attention effect in the early N1 latency (140-180 ms) shifted most positively for the occluded condition. These results suggest that perceptual organization processes for object recognition transiently modulate spatial and feature selection processes in the visual cortex. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. The association between leisure time sedentary behaviour among adults and objective neighbourhood characteristics nearby home

    DEFF Research Database (Denmark)

    Storgaard, Rikke Lynge; Hansen, Henning Sten

    2017-01-01

    is to examine the association between neighbourhood walkability and availability of sports and recreational facilities within 400 and 800 m from home and leisure time sedentary time. METHODS: The study was based on a cross sectional health survey of 49,806 adults aged 16+, conducted in 2010. Self......-reported information on leisure time sedentary time was combined with GIS based measures of neighbourhood physical environment and individual characteristics taken from registers. A multilevel regression analysis was performed. RESULTS: Good availability of recreational and sports facilities in the neighbourhood...... sedentary time and the walkability index was less clear and overall insignificant. CONCLUSION: Neighbourhoods with good availability of sports facilities, parks and recreational areas support less leisure time sedentary time. Intervention efforts may benefit from emphasizing the importance of having...

  16. Blind source separation based on time-frequency morphological characteristics for rigid acoustic scattering by underwater objects

    Science.gov (United States)

    Yang, Yang; Li, Xiukun

    2016-06-01

    Separation of the components of rigid acoustic scattering by underwater objects is essential in obtaining the structural characteristics of such objects. To overcome the problem of rigid structures appearing to have the same spectral structure in the time domain, time-frequency Blind Source Separation (BSS) can be used in combination with image morphology to separate the rigid scattering components of different objects. Based on a highlight model, the separation of the rigid scattering structure of objects with time-frequency distribution is deduced. Using a morphological filter, different characteristics in a Wigner-Ville Distribution (WVD) observed for single auto term and cross terms can be simplified to remove any cross-term interference. By selecting time and frequency points of the auto terms signal, the accuracy of BSS can be improved. An experimental simulation has been used, with changes in the pulse width of the transmitted signal, the relative amplitude and the time delay parameter, in order to analyzing the feasibility of this new method. Simulation results show that the new method is not only able to separate rigid scattering components, but can also separate the components when elastic scattering and rigid scattering exist at the same time. Experimental results confirm that the new method can be used in separating the rigid scattering structure of underwater objects.

  17. Real-Time FPGA-Based Object Tracker with Automatic Pan-Tilt Features for Smart Video Surveillance Systems

    Directory of Open Access Journals (Sweden)

    Sanjay Singh

    2017-05-01

    Full Text Available The design of smart video surveillance systems is an active research field among the computer vision community because of their ability to perform automatic scene analysis by selecting and tracking the objects of interest. In this paper, we present the design and implementation of an FPGA-based standalone working prototype system for real-time tracking of an object of interest in live video streams for such systems. In addition to real-time tracking of the object of interest, the implemented system is also capable of providing purposive automatic camera movement (pan-tilt in the direction determined by movement of the tracked object. The complete system, including camera interface, DDR2 external memory interface controller, designed object tracking VLSI architecture, camera movement controller and display interface, has been implemented on the Xilinx ML510 (Virtex-5 FX130T FPGA Board. Our proposed, designed and implemented system robustly tracks the target object present in the scene in real time for standard PAL (720 × 576 resolution color video and automatically controls camera movement in the direction determined by the movement of the tracked object.

  18. Real-Time Attitude Control Algorithm for Fast Tumbling Objects under Torque Constraint

    Science.gov (United States)

    Tsuda, Yuichi; Nakasuka, Shinichi

    This paper describes a new control algorithm for achieving any arbitrary attitude and angular velocity states of a rigid body, even fast and complicated tumbling rotations, under some practical constraints. This technique is expected to be applied for the attitude motion synchronization to capture a non-cooperative, tumbling object in such missions as removal of debris from orbit, servicing broken-down satellites for repairing or inspection, rescue of manned vehicles, etc. For this objective, we have introduced a novel control algorithm called Free Motion Path Method (FMPM) in the previous paper, which was formulated as an open-loop controller. The next step of this consecutive work is to derive a closed-loop FMPM controller, and as the preliminary step toward the objective, this paper attempts to derive a conservative state variables representation of a rigid body dynamics. 6-Dimensional conservative state variables are introduced in place of general angular velocity-attitude angle representation, and how to convert between both representations are shown in this paper.

  19. A comparison between indirect and objective wear-time assessment of removable orthodontic appliances.

    Science.gov (United States)

    Schott, Timm C; Meyer-Gutknecht, Hannes; Mayer, Nicolai; Weber, Joachim; Weimer, Katja

    2017-04-01

    Patients do not always adhere to the wear times prescribed for removable orthodontic appliances. We evaluated the validity and usability of indirect wear-time assessment methods by comparing wear-time estimates with microelectronically measured wear times in patients with removable orthodontic appliances. Wear times of 33 expansion plates, 34 functional appliances, and 42 retention plates of patients aged 6-20 years (12.3±2.9 years, 50.5% female) were indirectly determined by practitioners using a questionnaire assessing five parameters on a 5-point Likert scale: appliance handling, appliance appearance, bite shift, tooth movement, and appliance fit. The perceived difficulty in assessing each parameter was rated. Actual wear times were evaluated with microelectronic sensors in the appliances. Regression analyses revealed that practitioners' decisions about wear times varied depending on the type of appliance and criteria used, with only one standard criterion best predicting estimated wear time for each appliance. Different standard criteria were better predictors of measured wear time: 22.3% of wear-time variability was explained by expansion plate appearance, 31.2% by functional appliance handling, and 18.8% by retainer fitting. However, practitioners rated the difficulty of assessment in most cases as 'easy'. The study was not double blinded for technical reasons, and practitioners may have considered the evaluation criteria more carefully than in normal daily practice. Practitioners' decisions about wear times based on standard criteria strongly vary depending on the type of appliance and criteria used. © The Author 2016. Published by Oxford University Press on behalf of the European Orthodontic Society. All rights reserved. For permissions, please email: journals.permissions@oup.com

  20. Real-time C++ efficient object-oriented and template microcontroller programming

    CERN Document Server

    Kormanyos, Christopher

    2013-01-01

    This is a highly practical guide to programming real-time embedded microcontroller systems in C++. Its many examples are backed by real-time performance measurements and size analyses that quantify the true cost of the code to the last byte and microsecond.

  1. Framing Health Messages for Adolescents: Should We Use Objective Time Periods, Temporal Benchmarks, or Both?

    Science.gov (United States)

    McKay, Michael T.; Cole, Jon C.; Sumnall, Harry R.; Goudie, Andrew J.

    2012-01-01

    Time perspective is a cognitive-motivational construct, which has been shown to be related to decision-making, motivation and adjustment. The majority of research into time perspective has been conducted in college students and/or general population samples. Focus groups were held as part of a larger investigation into the relationship between…

  2. Who children spend time with after school: associations with objectively recorded indoor and outdoor physical activity

    Science.gov (United States)

    2014-01-01

    Background Understanding how the determinants of behaviour vary by context may support the design of interventions aiming to increase physical activity. Such factors include independent mobility, time outdoors and the availability of other children. At present little is known about who children spend their time with after school, how this relates to time spent indoors or outdoors and activity in these locations. This study aimed to quantify who children spend their time with when indoors or outdoors and associations with moderate to vigorous physical activity (MVPA). Methods Participants were 427 children aged 10–11 from Bristol, UK. Physical activity was recorded using an accelerometer (Actigraph GT1M) and matched to Global Positioning System receiver (Garmin Foretrex 201) data to differentiate indoor and outdoor location. Children self-reported who they spent time with after school until bed-time using a diary. Each 10 second epoch was coded as indoors or outdoors and for ‘who with’ (alone, friend, brother/sister, mum/dad, other grown-up) creating 10 possible physical activity contexts. Time spent and MVPA were summarised for each context. Associations between time spent in the different contexts and MVPA were examined using multiple linear regression adjusting for daylight, age, deprivation and standardised body mass index. Results During the after school period, children were most often with their mum/dad or alone, especially when indoors. When outdoors more time was spent with friends (girls: 32.1%; boys: 28.6%) than other people or alone. Regression analyses suggested hours outdoors with friends were positively associated with minutes of MVPA for girls (beta-coefficient [95% CI]: 17.4 [4.47, 30.24]) and boys (17.53 [2.76, 32.31]). Being outdoors with brother/sister was associated with MVPA for girls (21.2 [14.17, 28.25]) but not boys. Weaker associations were observed for time indoors with friends (girls: 4.61 [1.37, 7.85]; boys: (7.42 [2.99, 11

  3. QUASI-STELLAR OBJECT SELECTION ALGORITHM USING TIME VARIABILITY AND MACHINE LEARNING: SELECTION OF 1620 QUASI-STELLAR OBJECT CANDIDATES FROM MACHO LARGE MAGELLANIC CLOUD DATABASE

    International Nuclear Information System (INIS)

    Kim, Dae-Won; Protopapas, Pavlos; Alcock, Charles; Trichas, Markos; Byun, Yong-Ik; Khardon, Roni

    2011-01-01

    We present a new quasi-stellar object (QSO) selection algorithm using a Support Vector Machine, a supervised classification method, on a set of extracted time series features including period, amplitude, color, and autocorrelation value. We train a model that separates QSOs from variable stars, non-variable stars, and microlensing events using 58 known QSOs, 1629 variable stars, and 4288 non-variables in the MAssive Compact Halo Object (MACHO) database as a training set. To estimate the efficiency and the accuracy of the model, we perform a cross-validation test using the training set. The test shows that the model correctly identifies ∼80% of known QSOs with a 25% false-positive rate. The majority of the false positives are Be stars. We applied the trained model to the MACHO Large Magellanic Cloud (LMC) data set, which consists of 40 million light curves, and found 1620 QSO candidates. During the selection none of the 33,242 known MACHO variables were misclassified as QSO candidates. In order to estimate the true false-positive rate, we crossmatched the candidates with astronomical catalogs including the Spitzer Surveying the Agents of a Galaxy's Evolution LMC catalog and a few X-ray catalogs. The results further suggest that the majority of the candidates, more than 70%, are QSOs.

  4. The effect of substrate composition and storage time on urine specific gravity in dogs.

    Science.gov (United States)

    Steinberg, E; Drobatz, K; Aronson, L

    2009-10-01

    The purpose of this study is to evaluate the effects of substrate composition and storage time on urine specific gravity in dogs. A descriptive cohort study of 15 dogs. The urine specific gravity of free catch urine samples was analysed during a 5-hour time period using three separate storage methods; a closed syringe, a diaper pad and non-absorbable cat litter. The urine specific gravity increased over time in all three substrates. The syringe sample had the least change from baseline and the diaper sample had the greatest change from baseline. The urine specific gravity for the litter and diaper samples had a statistically significant increase from the 1-hour to the 5-hour time point. The urine specific gravity from canine urine stored either on a diaper or in a non-absorbable litter increased over time. Although the change was found to be statistically significant over the 5-hour study period it is unlikely to be clinically significant.

  5. DIRADTM - a system for real time detection and identification of radioactive objects

    International Nuclear Information System (INIS)

    Guillot, L.; Reboli, A.

    2009-01-01

    The authors present the DIRAD system (DIRAD stands for Detection and Identification of Radionuclides), an automatic system for real time identification of a radioactive anomaly and its interpretation in terms of risk level. It can be adapted to different contexts: pedestrian control, parcel or luggage control, road traffic control, and so on. In case of risk detection, an alert is transmitted in real time to a supervision station along with the whole set of spectral data

  6. Automated analysis of art object surfaces using time-averaged digital speckle pattern interferometry

    Science.gov (United States)

    Lukomski, Michal; Krzemien, Leszek

    2013-05-01

    Technical development and practical evaluation of a laboratory built, out-of-plane digital speckle pattern interferometer (DSPI) are reported. The instrument was used for non-invasive, non-contact detection and characterization of early-stage damage, like fracturing and layer separation, of painted objects of art. A fully automated algorithm was developed for recording and analysis of vibrating objects utilizing continuous-wave laser light. The algorithm uses direct, numerical fitting or Hilbert transformation for an independent, quantitative evaluation of the Bessel function at every point of the investigated surface. The procedure does not require phase modulation and thus can be implemented within any, even the simplest, DSPI apparatus. The proposed deformation analysis is fast and computationally inexpensive. Diagnosis of physical state of the surface of a panel painting attributed to Nicolaus Haberschrack (a late-mediaeval painter active in Krakow) from the collection of the National Museum in Krakow is presented as an example of an in situ application of the developed methodology. It has allowed the effectiveness of the deformation analysis to be evaluated for the surface of a real painting (heterogeneous colour and texture) in a conservation studio where vibration level was considerably higher than in the laboratory. It has been established that the methodology, which offers automatic analysis of the interferometric fringe patterns, has a considerable potential to facilitate and render more precise the condition surveys of works of art.

  7. Correspondence between objective and perceived walking times to urban destinations: Influence of physical activity, neighbourhood walkability, and socio-demographics

    Directory of Open Access Journals (Sweden)

    Dewulf Bart

    2012-10-01

    Full Text Available Abstract Background Doing regular physical activity has positive effects on health. Several environmental factors are identified as important correlates of physical activity. However, there seems to be a difference between perceived and objective measures of the environment. This study examines the influence of physical activity, neighbourhood walkability, and socio-demographic characteristics on the correspondence between self-reported and objectively measured walking time to urban destinations of adults in the city of Ghent (Belgium. Methods Previously collected survey data was used from 1164 respondents in the city of Ghent who reported walking times to various closest destinations in the neighbourhood of residence. These were compared with corresponding walking times that were objectively measured through geographical information systems. Physical activity was recorded over a 7-day period using accelerometers. Neighbourhood walkability was assessed on the basis of residential density, connectivity, and land-use mix. Results We observed a relatively poor agreement between objective and perceived walking times. Stronger agreements were noted amongst the most physically active group, while low-level walkers tended to overestimate walking time. Surprisingly, however, people residing in a low-walkable neighbourhood underestimated walking times more frequently relative to those in high-walkable neighbourhoods. Conclusions Researchers investigating the influence of environmental attributes on physical activity behavior should thus be cautious when using only self-reported environmental data, since these are a priori influenced by physical activity levels and various socio-demographic factors.

  8. The associations of objectively measured physical activity and sedentary time with cognitive functions in school-aged children.

    Directory of Open Access Journals (Sweden)

    Heidi J Syväoja

    Full Text Available Low levels of physical activity among children have raised concerns over the effects of a physically inactive lifestyle, not only on physical health but also on cognitive prerequisites of learning. This study examined how objectively measured and self-reported physical activity and sedentary behavior are associated with cognitive functions in school-aged children. The study population consisted of 224 children from five schools in the Jyväskylä school district in Finland (mean age 12.2 years; 56% girls, who participated in the study in the spring of 2011. Physical activity and sedentary time were measured objectively for seven consecutive days using the ActiGraph GT1M/GT3X accelerometer. Self-reported moderate to vigorous physical activity (MVPA and screen time were evaluated with the questions used in the "WHO Health Behavior in School-aged Children" study. Cognitive functions including visual memory, executive functions and attention were evaluated with a computerized Cambridge Neuropsychological Test Automated Battery by using five different tests. Structural equation modeling was applied to examine how objectively measured and self-reported MVPA and sedentary behavior were associated with cognitive functions. High levels of objectively measured MVPA were associated with good performance in the reaction time test. High levels of objectively measured sedentary time were associated with good performance in the sustained attention test. Objectively measured MVPA and sedentary time were not associated with other measures of cognitive functions. High amount of self-reported computer/video game play was associated with weaker performance in working memory test, whereas high amount of computer use was associated with weaker performance in test measuring shifting and flexibility of attention. Self-reported physical activity and total screen time were not associated with any measures of cognitive functions. The results of the present study propose

  9. Multi-Objective Optimization for Smart House Applied Real Time Pricing Systems

    Directory of Open Access Journals (Sweden)

    Yasuaki Miyazato

    2016-12-01

    Full Text Available A smart house generally has a Photovoltaic panel (PV, a Heat Pump (HP, a Solar Collector (SC and a fixed battery. Since the fixed battery can buy and store inexpensive electricity during the night, the electricity bill can be reduced. However, a large capacity fixed battery is very expensive. Therefore, there is a need to determine the economic capacity of fixed battery. Furthermore, surplus electric power can be sold using a buyback program. By this program, PV can be effectively utilized and contribute to the reduction of the electricity bill. With this in mind, this research proposes a multi-objective optimization, the purpose of which is electric demand control and reduction of the electricity bill in the smart house. In this optimal problem, the Pareto optimal solutions are searched depending on the fixed battery capacity. Additionally, it is shown that consumers can choose what suits them by comparing the Pareto optimal solutions.

  10. Relationships over time of subjective and objective elements of recovery in persons with schizophreni

    DEFF Research Database (Denmark)

    Jørgensen, Rikke; Zoffmann, Vibeke; Munk-Jørgensen, Povl

    2015-01-01

    of symptoms with four assessments of self-reports of subjective aspects of recovery. Participants were 101 outpatients with schizophrenia. Symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS) while subjective recovery was assessed with the Recovery Assessment Scale (RAS). Separate......Recovery from schizophrenia involves both subjective elements such as self-appraised wellness and objective elements such as symptom remission. Less is known about how they interact. To explore this issue, this study examined the relationship over the course of 1 year of four assessments...... Pearson׳s or Spearman׳s rank׳s correlation coefficients, calculated at all four measurement points, revealed the total symptom score was linked with lower levels of overall self-recovery at all four measurement points. The PANSS emotional discomfort subscale was linked with self-reported recovery at all...

  11. Ownership transfer for non-federate object and time management in developing an hla compliant logistics model.

    Energy Technology Data Exchange (ETDEWEB)

    Li, Z.

    1998-01-12

    A seaport simulation model, PORTSIM, has been developed for the Department of Defense (DOD) at Argonne National Laboratory. PORTSIM simulates the detailed processes of cargo loading and unloading in a seaport and provides throughput capability, resource utilization, and other important information on the bottlenecks in a seaport operation, which are crucial data in determining troop and equipment deployment capability. There are two key problems to solve in developing the HLA-compliant PORTSIM model. The first is the cargo object ownership transfer problem. In PORTSIM, cargo items, e.g. vehicles, containers, and pallets, are objects having asset attributes. Cargo comes to a seaport for loading or unloading. The ownership of a cargo object transfers from its carrier to the port and then from the port to a new carrier. Each owner of the cargo object is responsible for publishing and updating the attributes of the cargo object when it has the ownership. This creates a unique situation in developing the PORTSIM federate object model, that is, the ownership of the object instead of the attributes needs to be changed in handling the cargo object in the PORTSIM federate. The ownership management service provided by the current RTI does not directly address this issue. The second is the time management issue. PORTSIM is an event-driven simulation that models seaport operations over time. To make PORTSIM HLA compliant, time management must be addressed to allow for synchronization with other simulation models. This paper attempts to address these two issues and methodologies developed for solving these two problems.

  12. International study of objectively measured physical activity and sedentary time with body mass index and obesity

    DEFF Research Database (Denmark)

    Dyck, D Van; Cerin, E; De Bourdeaudhuij, I

    2015-01-01

    Background:Physical activity (PA) has been consistently implicated in the etiology of obesity, whereas recent evidence on the importance of sedentary time remains inconsistent. Understanding of dose-response associations of PA and sedentary time with overweight and obesity in adults can be improved...... effects of study site and gender.Methods:Data from the International Physical activity and the Environment Network (IPEN) Adult study were used. IPEN Adult is an observational multi-country cross-sectional study, and 12 sites in 10 countries are included. Participants wore an accelerometer for seven...

  13. Performance evaluation of the short-time objective intelligibility measure with different band importance functions

    DEFF Research Database (Denmark)

    Heidemann Andersen, Asger; de Haan, Jan Mark; Tan, Zheng-Hua

    performance measures: root-mean-squared-error, Pearson correlation, and Kendall rank correlation. The results show substantially improved performance when fitting and evaluating on the same dataset. However, this advantage does not necessarily subsist when fitting and evaluating on different datasets. When...... with a filter bank, 2) envelopes are extracted from each band, 3) the temporal correlation between clean and degraded envelopes is computed in short time segments, and 4) the correlation is averaged across time and frequency bands to obtain the final output. An unusual choice in the design of the STOI measure...

  14. Efficient and equitable design of marine protected areas in Fiji through inclusion of stakeholder-specific objectives in conservation planning.

    Science.gov (United States)

    Gurney, Georgina G; Pressey, Robert L; Ban, Natalie C; Álvarez-Romero, Jorge G; Jupiter, Stacy; Adams, Vanessa M

    2015-10-01

    The efficacy of protected areas varies, partly because socioeconomic factors are not sufficiently considered in planning and management. Although integrating socioeconomic factors into systematic conservation planning is increasingly advocated, research is needed to progress from recognition of these factors to incorporating them effectively in spatial prioritization of protected areas. We evaluated 2 key aspects of incorporating socioeconomic factors into spatial prioritization: treatment of socioeconomic factors as costs or objectives and treatment of stakeholders as a single group or multiple groups. Using as a case study the design of a system of no-take marine protected areas (MPAs) in Kubulau, Fiji, we assessed how these aspects affected the configuration of no-take MPAs in terms of trade-offs between biodiversity objectives, fisheries objectives, and equity in catch losses among fisher stakeholder groups. The achievement of fisheries objectives and equity tended to trade-off concavely with increasing biodiversity objectives, indicating that it is possible to achieve low to mid-range biodiversity objectives with relatively small losses to fisheries and equity. Importantly, the extent of trade-offs depended on the method used to incorporate socioeconomic data and was least severe when objectives were set for each fisher stakeholder group explicitly. We found that using different methods to incorporate socioeconomic factors that require similar data and expertise can result in plans with very different impacts on local stakeholders. © 2015 Society for Conservation Biology.

  15. Sleep restriction therapy for insomnia is associated with reduced objective total sleep time, increased daytime somnolence, and objectively impaired vigilance: implications for the clinical management of insomnia disorder.

    Science.gov (United States)

    Kyle, Simon D; Miller, Christopher B; Rogers, Zoe; Siriwardena, A Niroshan; Macmahon, Kenneth M; Espie, Colin A

    2014-02-01

    To investigate whether sleep restriction therapy (SRT) is associated with reduced objective total sleep time (TST), increased daytime somnolence, and impaired vigilance. Within-subject, noncontrolled treatment investigation. Sleep research laboratory. Sixteen patients [10 female, mean age = 47.1 (10.8) y] with well-defined psychophysiological insomnia (PI), reporting TST ≤ 6 h. Patients were treated with single-component SRT over a 4-w protocol, sleeping in the laboratory for 2 nights prior to treatment initiation and for 3 nights (SRT night 1, 8, 22) during the acute interventional phase. The psychomotor vigilance task (PVT) was completed at seven defined time points [day 0 (baseline), day 1,7,8,21,22 (acute treatment) and day 84 (3 mo)]. The Epworth Sleepiness Scale (ESS) was completed at baseline, w 1-4, and 3 mo. Subjective sleep outcomes and global insomnia severity significantly improved before and after SRT. There was, however, a robust decrease in PSG-defined TST during acute implementation of SRT, by an average of 91 min on night 1, 78 min on night 8, and 69 min on night 22, relative to baseline (P insomnia.

  16. Multi-objective Mobile Robot Scheduling Problem with Dynamic Time Windows

    DEFF Research Database (Denmark)

    Dang, Vinh Quang; Nielsen, Izabela Ewa; Steger-Jensen, Kenn

    2012-01-01

    This paper deals with the problem of scheduling feeding tasks of a single mobile robot which has capability of supplying parts to feeders on pro-duction lines. The performance criterion is to minimize the total traveling time of the robot and the total tardiness of the feeding tasks being scheduled...

  17. Innovation success over time of alliances with different strategic and cooperation objectives

    NARCIS (Netherlands)

    Manuhutu, Ari; von Raesfeld Meijer, Ariane; Geurts, Peter; Ebrahimi, Maryam

    2018-01-01

    In response to uncertainty of prospective technologies and how they might fit market demand, firms tend to establish R&D alliances. In this chapter the effect over time of continuation of underperforming R&D alliances on innovation performance during the pre-market stage is investigated. This stage

  18. Real time radial and tangential tomosynthesis system dedicated to on line x-ray examination of moving objects

    International Nuclear Information System (INIS)

    Antonakios, M.; Rizo, Ph.; Lamarque, P.

    2000-01-01

    This presentation describes a system able to compute and display in real time a reconstructed image of a moving object using tomosynthesis methods. The object being moved on a known trajectory between the x-ray source and a detector, the tomosynthesis is focused on a given surface of the object and allows to reconstruct a sharp image of the structure on the surface superimposed to a blurred image of the surrounding plane. The developed tomosynthesis algorithm is based on a set of look up tables which provide for each position of the object on the trajectory, the projection of a given point of the imaged surface of the object on the detector. Several hundreds of frames can be combined to compute the tomosynthesis image. The signal-to-noise ratio obtained on processed images is equivalent to the one obtained by averaging images with a static object. In order to speed up the tomosynthesis reconstruction and to reach the video frame rate, we integrated a DSP based hardware in a PC host. The geometric calibration parameters and the look up tables are pre-computed on the PC. The on-line tomosynthesis calculation is carried out by the multi DSP architecture which manages in real time, frame acquisition, parallel tomosynthesis calculation and output image display. On this particular implementation of tomosynthesis, up to hundred video frames can be combined. We illustrate the potential of this system on an application of the tomosynthesis to solid rocket motor examination

  19. A Twin Study of Objective and Subjective Pubertal Timing and Peer Influence on Risk-Taking.

    Science.gov (United States)

    Kretsch, Natalie; Mendle, Jane; Harden, K Paige

    2016-03-01

    The current study used a behavioral genetic design to test whether three measures of pubertal timing moderated peer influence on risk-taking in a sample of 248 female adolescent twin pairs ( M age =16.0, SD =1.5) from the National Longitudinal Study of Adolescent Health. Peer influence was operationalized as the quasi-causal association between girls' self-reported risk-taking and the risk-taking reported by their friends. Girls with earlier ages at menarche and who perceived themselves as more developed than peers were more susceptible to peer influence on risk-taking. However, age-standardized ratings of body changes did not moderate peer influence. This study highlights distinctions between multiple measures of pubertal timing, using an innovative synthesis of genetically informative data and peer nomination data.

  20. Online Self-Organizing Network Control with Time Averaged Weighted Throughput Objective

    Directory of Open Access Journals (Sweden)

    Zhicong Zhang

    2018-01-01

    Full Text Available We study an online multisource multisink queueing network control problem characterized with self-organizing network structure and self-organizing job routing. We decompose the self-organizing queueing network control problem into a series of interrelated Markov Decision Processes and construct a control decision model for them based on the coupled reinforcement learning (RL architecture. To maximize the mean time averaged weighted throughput of the jobs through the network, we propose a reinforcement learning algorithm with time averaged reward to deal with the control decision model and obtain a control policy integrating the jobs routing selection strategy and the jobs sequencing strategy. Computational experiments verify the learning ability and the effectiveness of the proposed reinforcement learning algorithm applied in the investigated self-organizing network control problem.

  1. An analytic solution to the alibi query in the space-time prisms model for moving object data

    OpenAIRE

    GRIMSON, Rafael; KUIJPERS, Bart; OTHMAN, Walied

    2010-01-01

    Moving objects produce trajectories, which are stored in databases by means of finite samples of time-stamped locations. When also speed limitations in these sample points are known, space-time prisms (also called beads) (Egenhofer 2003, Miller 2005, Pfoser and Jensen 1999) can be used to model the uncertainty about an object’s location in between sample points. In this setting, a query of particular interest, that has been studied in the literature of geographic information systems (GIS), is...

  2. Parallel Object Oriented MD Simulation Program for Long Time Simulations of Metallic Glasses and Undercooled Liquids

    Science.gov (United States)

    Böddeker, B.; Teichler, H.

    The MD simulation program TABB is motivated by the need of long time simulations for the investigation of slow processes near the glass transition of glass forming alloys. TABB is written in C++ with a high degree of flexibility: TABB allows the use of any short ranged pair potentials or EAM potentials, by generating and using a spline representation of all functions and their derivatives. TABB supports several numerical integration algorithms like the Runge-Kotta or the modified Gear-predictor-corrector algorithm of order five. The boundary conditions can be chosen to resemble the geometry of bulk materials or films. The simulation box length or the pressure can be fixed for each dimension separately. TABB may be used in isokinetic, isoenergeric or canonic (with random forces) mode. TABB contains a simple instruction interpreter to easily control the parameters and options during the simulation. The same source code can be compiled either for workstations or for parallel computers. The main optimization goal of TABB is to allow long time simulations of medium or small sized systems. To make this possible, much attention is spent on the optimized communication between the nodes. TABB uses a domain decomposition procedure. To use many nodes with a small system, the domain size has to be small compared to the range of particle interactions. In the limit of many nodes for only few atoms, the bottle neck of communication is the latency time. TABB minimizes the number of pairs of domains containing atoms that interact between these domains. This procedure minimizes the need of communication calls between pairs of nodes. TABB decides automatically, to how many, and to which directions the decomposition shall be applied. E.g., in the case of one dimensional domain decomposition, the simulation box is only split into "slabs" along a selected direction. The three dimensional domain decomposition is best with respect to the number of interacting domains only for simulations

  3. Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children

    DEFF Research Database (Denmark)

    Schnurr, Theresia Maria; Viitasalo, A; Eloranta, A-M

    2018-01-01

    Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used Mendelian randomization to examine the causal relations between body mass index......=0.072). Childhood BMI may have a causal influence on sedentary time but not on total physical activity or MVPA in young children. Our results provide important insights into the regulation of movement behaviour in childhood.International Journal of Obesity accepted article preview online, 26...

  4. Objectively measured physical activity and sedentary time are associated with cardiometabolic risk factors in adults with prediabetes

    DEFF Research Database (Denmark)

    Swindell, Nils; Mackintosh, Kelly; McNarry, Melitta

    2018-01-01

    OBJECTIVE: The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes. RESEARCH DESIGN AND METHODS: Participants (n = 2,326; 25-70 years old, 67% female) from eight countries...

  5. Real-time object tracking system based on field-programmable gate array and convolution neural network

    Directory of Open Access Journals (Sweden)

    Congyi Lyu

    2016-12-01

    Full Text Available Vision-based object tracking has lots of applications in robotics, like surveillance, navigation, motion capturing, and so on. However, the existing object tracking systems still suffer from the challenging problem of high computation consumption in the image processing algorithms. The problem can prevent current systems from being used in many robotic applications which have limitations of payload and power, for example, micro air vehicles. In these applications, the central processing unit- or graphics processing unit-based computers are not good choices due to the high weight and power consumption. To address the problem, this article proposed a real-time object tracking system based on field-programmable gate array, convolution neural network, and visual servo technology. The time-consuming image processing algorithms, such as distortion correction, color space convertor, and Sobel edge, Harris corner features detector, and convolution neural network were redesigned using the programmable gates in field-programmable gate array. Based on the field-programmable gate array-based image processing, an image-based visual servo controller was designed to drive a two degree of freedom manipulator to track the target in real time. Finally, experiments on the proposed system were performed to illustrate the effectiveness of the real-time object tracking system.

  6. Objectively measured sedentary time may predict insulin resistance independent of moderate- and vigorous-intensity physical activity

    NARCIS (Netherlands)

    Helmerhorst, Hendrik J. F.; Wijndaele, Katrien; Brage, Søren; Wareham, Nicholas J.; Ekelund, Ulf

    2009-01-01

    To examine the prospective association between objectively measured time spent sedentary and insulin resistance and whether this association is independent of moderate- and vigorous-intensity physical activity (MVPA) and other relevant confounders. This was a population-based study (Medical Research

  7. Do extended objects move along the geodesics in the Riemann space-time

    International Nuclear Information System (INIS)

    Denisov, V.I.; Logunov, A.A.; Mestvirishvili, M.A.

    1981-01-01

    Movement of an extended self-gravitating body in the gravitational field of another distant body is studied in the postnewtonian approximation of arbitrary metrical gravitational theory. Comparison of the mass center acceleration of the extended body with the acceleration of a point body moving in the Riemann space-time, the metrics of which is formally equivalent to the metrics of two moving extended bodies, shows that in any metrical gravitation theory with conservation laws of energy and momentum of the matter and gravitational field taken together, the mass center of the extended body does not, in general case, move along the geodesics of the Riemann space-time. Application of the general formulas obtained to the system Sun-Earth combined with the experimental data of the lunar laser ranging, shows that the Earth in its orbital motion is oscillating with respect to reference geodesics, with the period about one hour and the amplitude not less than 10 -2 cm. This amplitude is of the postnewtonian magnitude and as a consequence, the deviation of the Earth movement from the geodesical movement can be observed in the experiment possessing the postnewtonian accuracy. The difference between the acceleration of the Earth mass center and that of a test body in the postnewtonian approximation is equal to 10 -7 part of the Earth acceleration. The ratio of the passive gravitational mass of the Earth (defined according to Will) and its inert mass differs from 1 by 10 -8 approximately [ru

  8. Observing microscopic structures of a relativistic object using a time-stretch strategy

    Science.gov (United States)

    Roussel, E.; Evain, C.; Le Parquier, M.; Szwaj, C.; Bielawski, S.; Manceron, L.; Brubach, J.-B.; Tordeux, M.-A.; Ricaud, J.-P.; Cassinari, L.; Labat, M.; Couprie, M.-E.; Roy, P.

    2015-05-01

    Emission of light by a single electron moving on a curved trajectory (synchrotron radiation) is one of the most well-known fundamental radiation phenomena. However experimental situations are more complex as they involve many electrons, each being exposed to the radiation of its neighbors. This interaction has dramatic consequences, one of the most spectacular being the spontaneous formation of spatial structures inside electrons bunches. This fundamental effect is actively studied as it represents one of the most fundamental limitations in electron accelerators, and at the same time a source of intense terahertz radiation (Coherent Synchrotron Radiation, or CSR). Here we demonstrate the possibility to directly observe the electron bunch microstructures with subpicosecond resolution, in a storage ring accelerator. The principle is to monitor the terahertz pulses emitted by the structures, using a strategy from photonics, time-stretch, consisting in slowing-down the phenomena before recording. This opens the way to unpreceeded possibilities for analyzing and mastering new generation high power coherent synchrotron sources.

  9. Multi-Objective Planning of Multi-Type Distributed Generation Considering Timing Characteristics and Environmental Benefits

    Directory of Open Access Journals (Sweden)

    Yajing Gao

    2014-09-01

    Full Text Available This paper presents a novel approach to multi-type distributed generation (DG planning based on the analysis of investment and income brought by grid-connected DG. Firstly, the timing characteristics of loads and DG outputs, as well as the environmental benefits of DG are analyzed. Then, on the basis of the classification of daily load sequences, the typical daily load sequence and the typical daily output sequence of DG per unit capacity can be computed. The proposed planning model takes the location, capacity and types of DG into account as optimization variables. An improved adaptive genetic algorithm is proposed to solve the model. Case studies have been carried out on the IEEE 14-node distribution system to verify the feasibility and effectiveness of the proposed method and model.

  10. Modified SURF Algorithm Implementation on FPGA For Real-Time Object Tracking

    Directory of Open Access Journals (Sweden)

    Tomyslav Sledevič

    2013-05-01

    Full Text Available The paper describes the FPGA-based implementation of the modified speeded-up robust features (SURF algorithm. FPGA was selected for parallel process implementation using VHDL to ensure features extraction in real-time. A sliding 84×84 size window was used to store integral pixels and accelerate Hessian determinant calculation, orientation assignment and descriptor estimation. The local extreme searching was used to find point of interest in 8 scales. The simplified descriptor and orientation vector were calculated in parallel in 6 scales. The algorithm was investigated by tracking marker and drawing a plane or cube. All parts of algorithm worked on 25 MHz clock. The video stream was generated using 60 fps and 640×480 pixel camera.Article in Lithuanian

  11. A bi-objective model for optimizing replacement time of age and block policies with consideration of spare parts’ availability

    Science.gov (United States)

    Alsyouf, Imad

    2018-05-01

    Reliability and availability of critical systems play an important role in achieving the stated objectives of engineering assets. Preventive replacement time affects the reliability of the components, thus the number of system failures encountered and its downtime expenses. On the other hand, spare parts inventory level is a very critical factor that affects the availability of the system. Usually, the decision maker has many conflicting objectives that should be considered simultaneously for the selection of the optimal maintenance policy. The purpose of this research was to develop a bi-objective model that will be used to determine the preventive replacement time for three maintenance policies (age, block good as new, block bad as old) with consideration of spare parts’ availability. It was suggested to use a weighted comprehensive criterion method with two objectives, i.e. cost and availability. The model was tested with a typical numerical example. The results of the model demonstrated its effectiveness in enabling the decision maker to select the optimal maintenance policy under different scenarios and taking into account preferences with respect to contradicting objectives such as cost and availability.

  12. Non-specific Effects of Vaccines and Stunting: Timing May Be Essential

    Directory of Open Access Journals (Sweden)

    Mike L.T. Berendsen

    2016-06-01

    Conclusions: We found a general time-dependent pattern of non-specific effects of vaccination, with positive associations for vaccinations given early in life and negative associations for vaccinations given later in infancy. If confirmed in further research, our findings may provide a new perspective on the non-specific effects of vaccination.

  13. Long-Term Correlates of Objectively Measured Physical Activity and Sedentary Time in Norwegian Men and Women.

    Science.gov (United States)

    Solbraa, Ane Kristiansen; Ekelund, Ulf; Holme, Ingar M; Graff-Iversen, Sidsel; Steene-Johannessen, Jostein; Aadland, Eivind; Anderssen, Sigmund Alfred

    2015-11-01

    Sex, age, body mass index (BMI), perceived health and health behavior are correlates known to affect physical activity and sedentary time. However, studies have often been cross-sectional, and less is known about long-term correlates. Thus, the aims were to investigate 1) the associations between a set of characteristics (demographic, biological, psychological, and behavioral) and objectively measured physical activity and sedentary time at 13-year follow-up, and 2) the association between changes in these characteristics over time and physical activity and sedentary time. Baseline characteristics were collected in 40-year-olds in 1996, and follow-up data on objectively measured physical activity and sedentary time were obtained in 2009 (n = 240). Data were analyzed by multiple linear regressions. Self-reported physical activity (P physical activity (MVPA) whereas BMI (P = .034) and increased BMI (P = .014) were negatively associated with MVPA at follow-up. Women spent less time being sedentary than men (P = .019). Education (P < .001) was positively associated and improved perceived health (P = .010) was negatively associated with sedentary time at follow-up. MVPA and sedentary time at follow-up were associated with behavioral, biological and demographic correlates. However, the nature of our analyses prevents us from inferring causality.

  14. Formal Specification and Verification of Real-Time Multi-Agent Systems using Timed-Arc Petri Nets

    Directory of Open Access Journals (Sweden)

    QASIM, A.

    2015-08-01

    Full Text Available In this study we have formally specified and verified the actions of communicating real-time software agents (RTAgents. Software agents are expected to work autonomously and deal with unfamiliar situations astutely. Achieving cent percent test cases coverage for these agents has always been a problem due to limited resources. Also a high degree of dependability and predictability is expected from real-time software agents. In this research we have used Timed-Arc Petri Net's for formal specification and verification. Formal specification of e-agents has been done in the past using Linear Temporal Logic (LTL but we believe that Timed-Arc Petri Net's being more visually expressive provides a richer framework for such formalism. A case study of Stock Market System (SMS based on Real Time Multi Agent System framework (RTMAS using Timed-Arc Petri Net's is taken to illustrate the proposed modeling approach. The model was verified used AF, AG, EG, and EF fragments of Timed Computational Tree Logic (TCTL via translations to timed automata.

  15. The Role of Sensory-Motor Information in Object Recognition: Evidence from Category-Specific Visual Agnosia

    Science.gov (United States)

    Wolk, D.A.; Coslett, H.B.; Glosser, G.

    2005-01-01

    The role of sensory-motor representations in object recognition was investigated in experiments involving AD, a patient with mild visual agnosia who was impaired in the recognition of visually presented living as compared to non-living entities. AD named visually presented items for which sensory-motor information was available significantly more…

  16. Object-Based Classification of Grasslands from High Resolution Satellite Image Time Series Using Gaussian Mean Map Kernels

    Directory of Open Access Journals (Sweden)

    Mailys Lopes

    2017-07-01

    Full Text Available This paper deals with the classification of grasslands using high resolution satellite image time series. Grasslands considered in this work are semi-natural elements in fragmented landscapes, i.e., they are heterogeneous and small elements. The first contribution of this study is to account for grassland heterogeneity while working at the object level by modeling its pixels distributions by a Gaussian distribution. To measure the similarity between two grasslands, a new kernel is proposed as a second contribution: the α -Gaussian mean kernel. It allows one to weight the influence of the covariance matrix when comparing two Gaussian distributions. This kernel is introduced in support vector machines for the supervised classification of grasslands from southwest France. A dense intra-annual multispectral time series of the Formosat-2 satellite is used for the classification of grasslands’ management practices, while an inter-annual NDVI time series of Formosat-2 is used for old and young grasslands’ discrimination. Results are compared to other existing pixel- and object-based approaches in terms of classification accuracy and processing time. The proposed method is shown to be a good compromise between processing speed and classification accuracy. It can adapt to the classification constraints, and it encompasses several similarity measures known in the literature. It is appropriate for the classification of small and heterogeneous objects such as grasslands.

  17. Eating patterns and leisure-time exercise among active duty military personnel: comparison to the Healthy People objectives.

    Science.gov (United States)

    Smith, Tracey J; Dotson, Laura E; Young, Andrew J; White, Alan; Hadden, Louise; Bathalon, Gaston P; Funderburk, LesLee; Marriott, Bernadette P

    2013-07-01

    To assess whether active duty military personnel meet Healthy People 2010 objectives for physical activity and fruit, vegetable, and whole-grain intake; the relationship of select demographic characteristics, lifestyle factors (eg, smoking), and eating patterns (eg, frequency and location of meals) on achieving diet and exercise-related Healthy People 2010 objectives; and the relationship of eating patterns to self-reported weight gain. Secondary data from 15,747 participants in the 2005 Department of Defense Health Related Behaviors Survey was analyzed. More than 57% of respondents met the Healthy People 2010 guidelines for moderate or vigorous leisure exercise but only 3% reported eating fruit (once), vegetables (3 times), and whole grains (3 times) daily. Individuals who reported gaining weight during the previous year were more likely to skip breakfast and eat at, or from, a restaurant ≥2 times per week compared with those who did not gain weight (Pexercise (OR 0.71). Military personnel who skipped breakfast ≥2 times per week (OR 0.45) or ate at a restaurant/takeout food (OR 0.54) ≥2 times per week were significantly less likely to meet Healthy People 2010 guidelines for food intake (defined as achieving a daily intake of one or more fruits, three or more vegetables, and three or more servings of whole grains) and exercise (OR 0.88 and 0.82, respectively). Although the majority of military personnel met guidelines for physical activity, their intake of fruits, vegetables, and whole grains was suboptimal. Skipping breakfast and eating at, or from, restaurants were risk factors for poor nutrient intake and associated with weight gain. These data suggest that skipping breakfast and eating out deter achieving Healthy People 2010 objectives and provide targets for military programs to promote achieving these objectives. Copyright © 2013 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

  18. Improving software requirements specification for safety-related systems using the fault tree developed by an object-based method

    International Nuclear Information System (INIS)

    Cepin, M.; Mavko, B.

    1998-01-01

    A modification of the fault tree analysis is presented. The new fault tree integrates structural and behavioral models of a system. Information on the system structure is captured in the name of each gate and basic event of the fault tree. Information on the system behavior is captured in their description. Behavior is expressed using the axiomatic notation based on first order predicate logic. The new fault tree is a useful model for analysis and improvement of software requirements specification. The benefit of such improvements is reduced probability of failures in specification, which in turn results in increased reliability of the software.(author)

  19. Reactionless robust finite-time control for manipulation of passive objects by free-floating space robots

    International Nuclear Information System (INIS)

    Guo Sheng-Peng; Li Dong-Xu; Meng Yun-He; Fan Cai-Zhi

    2014-01-01

    On-orbit servicing requires efficient techniques for manipulating passive objects. The paper aims at developing a reactionless control method that drives the manipulator to manipulate passive objects with high precision, while inducing no disturbances to its base attitude. To this end, decomposition of the target dynamics from the base dynamics is discussed, so that they can be considered as two independent subsystems. A reactionless nonlinear controller is presented, which ensures high-precision manipulation of the targets and that the base orientation is unchanged. This is achieved by combining the robust finite-time control with the reaction null space. Finally, the performance of the proposed method is examined by comparing it with that of a reactionless PD controller and a pure finite-time controller. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  20. Objectively measured physical environmental neighbourhood factors are not associated with accelerometer-determined total sedentary time in adults

    OpenAIRE

    Compernolle, Sofie; De Cocker, Katrien; Mackenbach, Joreintje D.; Van Nassau, Femke; Lakerveld, Jeroen; Cardon, Greet; De Bourdeaudhuij, Ilse

    2017-01-01

    Background: The physical neighbourhood environment may influence adults' sedentary behaviour. Yet, most studies examining the association between the physical neighbourhood environment and sedentary behaviour rely on self-reported data of either the physical neighbourhood environment and/or sedentary behaviour. The aim of this study was to investigate the associations between objectively measured physical environmental neighbourhood factors and accelerometer-determined total sedentary time in...

  1. Data Rods: High Speed, Time-Series Analysis of Massive Cryospheric Data Sets Using Object-Oriented Database Methods

    Science.gov (United States)

    Liang, Y.; Gallaher, D. W.; Grant, G.; Lv, Q.

    2011-12-01

    Change over time, is the central driver of climate change detection. The goal is to diagnose the underlying causes, and make projections into the future. In an effort to optimize this process we have developed the Data Rod model, an object-oriented approach that provides the ability to query grid cell changes and their relationships to neighboring grid cells through time. The time series data is organized in time-centric structures called "data rods." A single data rod can be pictured as the multi-spectral data history at one grid cell: a vertical column of data through time. This resolves the long-standing problem of managing time-series data and opens new possibilities for temporal data analysis. This structure enables rapid time- centric analysis at any grid cell across multiple sensors and satellite platforms. Collections of data rods can be spatially and temporally filtered, statistically analyzed, and aggregated for use with pattern matching algorithms. Likewise, individual image pixels can be extracted to generate multi-spectral imagery at any spatial and temporal location. The Data Rods project has created a series of prototype databases to store and analyze massive datasets containing multi-modality remote sensing data. Using object-oriented technology, this method overcomes the operational limitations of traditional relational databases. To demonstrate the speed and efficiency of time-centric analysis using the Data Rods model, we have developed a sea ice detection algorithm. This application determines the concentration of sea ice in a small spatial region across a long temporal window. If performed using traditional analytical techniques, this task would typically require extensive data downloads and spatial filtering. Using Data Rods databases, the exact spatio-temporal data set is immediately available No extraneous data is downloaded, and all selected data querying occurs transparently on the server side. Moreover, fundamental statistical

  2. A Prototype Lisp-Based Soft Real-Time Object-Oriented Graphical User Interface for Control System Development

    Science.gov (United States)

    Litt, Jonathan; Wong, Edmond; Simon, Donald L.

    1994-01-01

    A prototype Lisp-based soft real-time object-oriented Graphical User Interface for control system development is presented. The Graphical User Interface executes alongside a test system in laboratory conditions to permit observation of the closed loop operation through animation, graphics, and text. Since it must perform interactive graphics while updating the screen in real time, techniques are discussed which allow quick, efficient data processing and animation. Examples from an implementation are included to demonstrate some typical functionalities which allow the user to follow the control system's operation.

  3. Real-time surgical simulation for deformable soft-tissue objects with a tumour using Boundary Element techniques

    Science.gov (United States)

    Wang, P.; Becker, A. A.; Jones, I. A.; Glover, A. T.; Benford, S. D.; Vloeberghs, M.

    2009-08-01

    A virtual-reality real-time simulation of surgical operations that incorporates the inclusion of a hard tumour is presented. The software is based on Boundary Element (BE) technique. A review of the BE formulation for real-time analysis of two-domain deformable objects, using the pre-solution technique, is presented. The two-domain BE software is incorporated into a surgical simulation system called VIRS to simulate the initiation of a cut on the surface of the soft tissue and extending the cut deeper until the tumour is reached.

  4. Real-time surgical simulation for deformable soft-tissue objects with a tumour using Boundary Element techniques

    International Nuclear Information System (INIS)

    Wang, P; Becker, A A; Jones, I A; Glover, A T; Benford, S D; Vloeberghs, M

    2009-01-01

    A virtual-reality real-time simulation of surgical operations that incorporates the inclusion of a hard tumour is presented. The software is based on Boundary Element (BE) technique. A review of the BE formulation for real-time analysis of two-domain deformable objects, using the pre-solution technique, is presented. The two-domain BE software is incorporated into a surgical simulation system called VIRS to simulate the initiation of a cut on the surface of the soft tissue and extending the cut deeper until the tumour is reached.

  5. Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab).

    Science.gov (United States)

    Healy, Genevieve N; Wijndaele, Katrien; Dunstan, David W; Shaw, Jonathan E; Salmon, Jo; Zimmet, Paul Z; Owen, Neville

    2008-02-01

    We examined the associations of objectively measured sedentary time and physical activity with continuous indexes of metabolic risk in Australian adults without known diabetes. An accelerometer was used to derive the percentage of monitoring time spent sedentary and in light-intensity and moderate-to-vigorous-intensity activity, as well as mean activity intensity, in 169 Australian Diabetes, Obesity and Lifestyle Study (AusDiab) participants (mean age 53.4 years). Associations with waist circumference, triglycerides, HDL cholesterol, resting blood pressure, fasting plasma glucose, and a clustered metabolic risk score were examined. Independent of time spent in moderate-to-vigorous-intensity activity, there were significant associations of sedentary time, light-intensity time, and mean activity intensity with waist circumference and clustered metabolic risk. Independent of waist circumference, moderate-to-vigorous-intensity activity time was significantly beneficially associated with triglycerides. These findings highlight the importance of decreasing sedentary time, as well as increasing time spent in physical activity, for metabolic health.

  6. Evaluation of autoradiographs and images of biological objects with the electronically operating image analyzer 'Densitron II'. II. Determination of the specific and total radioactivity of single cells

    Energy Technology Data Exchange (ETDEWEB)

    Hess, J; Korn, U; Freyer, K; Ermisch, A [Karl-Marx-Universitaet, Leipzig (German Democratic Republic). Sektion Biowissenschaften; Akademie der Wissenschaften der DDR, Leipzig. Zentralinstitut fuer Isotopen- und Strahlenforschung)

    1976-01-01

    Using the TV image analyzer Densitron, transparencies and areas can be measured by the grey value discrimination method equidensitometry. The time, necessary for one measurement, is approximately 1 min, the standard deviations do not exceed 2%. Microscopical objects such as single cells can be analyzed by this method. Photo-blackings and areas have been measured in autoradiographs of goldfish brain-sections after injection of /sup 3/H-phenylalanine. As a parallel, blacking and area calibration curves were obtained which allowed a conversion of the relative values into absolute ones. Using this conversion method, neurons of different brain regions were in the range from 104 to 1476..mu..m/sup 2/ in area and from 4.17 to 14.43..mu..Ci . cm/sup -3/ in specific radioactivity. The standard deviations of the absolute values were 6 and 4.5%, respectively. On the basis of these and additional values (thickness of section, number of sections per cell), calculations of the total radioactivity of a cell section or the whole cell can be made.

  7. Time-wise change in neck pain in response to rehabilitation with specific resistance training

    DEFF Research Database (Denmark)

    Zebis, Mette Kreutzfeldt; Andersen, Christoffer H; Sundstrup, Emil

    2014-01-01

    in Copenhagen, Denmark. Women with neck pain >30 mm VAS (N = 131) were included in the present analysis. The training group (N = 77) performed specific resistance training for the neck/shoulder muscles three times a week, and the control group (N = 54) received advice to stay active. Participants of both groups......Purpose To determine the time-wise effect of specific resistance training on neck pain among industrial technicians with frequent neck pain symptoms. Methods Secondary analysis of a parallel-group cluster randomized controlled trial of 20 weeks performed at two large industrial production units...

  8. Observing how others lift light or heavy objects: time-dependent encoding of grip force in the primary motor cortex.

    Science.gov (United States)

    Alaerts, Kaat; de Beukelaar, Toon T; Swinnen, Stephan P; Wenderoth, Nicole

    2012-07-01

    During movement observation, corticomotor excitability of the observer's primary motor cortex (M1) is modulated according to the force requirements of the observed action. Here, we explored the time course of observation-induced force encoding. Force-related changes in M1-excitability were assessed by delivering transcranial magnetic stimulations at distinct temporal phases of an observed reach-grasp-lift action. Temporal changes in force-related electromyographic activity were also assessed during active movement execution. In observation conditions in which a heavy object was lifted, M1-excitability was higher compared to conditions in which a light object was lifted. Both during observation and execution, differential force encoding tended to gradually increase from the grasping phase until the late lift phase. Surprisingly, however, during observation, force encoding was already present at the early reach phase: a time point at which no visual cues on the object's weight were available to the observer. As the observer was aware that the same weight condition was presented repeatedly, this finding may indicate that prior predictions concerning the upcoming weight condition are reflected by M1 excitability. Overall, findings may provide indications that the observer's motor system represents motor predictions as well as muscular requirements to infer the observed movement goal.

  9. Some Specific Features of the Object of Prosecutorial Supervision over the Observance of Constitutional Rights of the Individual to Work

    Directory of Open Access Journals (Sweden)

    Daniil S. Tishkov

    2017-08-01

    Full Text Available The article defines the place of supervision functions within the system of the functions of prosecution bodies of the Russian Federation as one of the priority sectors of prosecutorial supervision. The legal regulation of prosecutorial supervision of the rights and freedoms of Russian Federation citizens is examined. The Author reveals the specific features of the subject of prosecutorial supervision in compliance with the constitutional rights of the individual to work based on the results of the current legislation system analysis. The assumption of the need for changes to the Prosecutor General of the Russian Federation organizational and administrative documents in order to increase the efficiency of prosecutorial supervision over the observance of individual’s constitutional rights to work is expressed.

  10. From brain synapses to systems for learning and memory: Object recognition, spatial navigation, timed conditioning, and movement control.

    Science.gov (United States)

    Grossberg, Stephen

    2015-09-24

    This article provides an overview of neural models of synaptic learning and memory whose expression in adaptive behavior depends critically on the circuits and systems in which the synapses are embedded. It reviews Adaptive Resonance Theory, or ART, models that use excitatory matching and match-based learning to achieve fast category learning and whose learned memories are dynamically stabilized by top-down expectations, attentional focusing, and memory search. ART clarifies mechanistic relationships between consciousness, learning, expectation, attention, resonance, and synchrony. ART models are embedded in ARTSCAN architectures that unify processes of invariant object category learning, recognition, spatial and object attention, predictive remapping, and eye movement search, and that clarify how conscious object vision and recognition may fail during perceptual crowding and parietal neglect. The generality of learned categories depends upon a vigilance process that is regulated by acetylcholine via the nucleus basalis. Vigilance can get stuck at too high or too low values, thereby causing learning problems in autism and medial temporal amnesia. Similar synaptic learning laws support qualitatively different behaviors: Invariant object category learning in the inferotemporal cortex; learning of grid cells and place cells in the entorhinal and hippocampal cortices during spatial navigation; and learning of time cells in the entorhinal-hippocampal system during adaptively timed conditioning, including trace conditioning. Spatial and temporal processes through the medial and lateral entorhinal-hippocampal system seem to be carried out with homologous circuit designs. Variations of a shared laminar neocortical circuit design have modeled 3D vision, speech perception, and cognitive working memory and learning. A complementary kind of inhibitory matching and mismatch learning controls movement. This article is part of a Special Issue entitled SI: Brain and Memory

  11. Typical Periods for Two-Stage Synthesis by Time-Series Aggregation with Bounded Error in Objective Function

    Energy Technology Data Exchange (ETDEWEB)

    Bahl, Björn; Söhler, Theo; Hennen, Maike; Bardow, André, E-mail: andre.bardow@ltt.rwth-aachen.de [Institute of Technical Thermodynamics, RWTH Aachen University, Aachen (Germany)

    2018-01-08

    Two-stage synthesis problems simultaneously consider here-and-now decisions (e.g., optimal investment) and wait-and-see decisions (e.g., optimal operation). The optimal synthesis of energy systems reveals such a two-stage character. The synthesis of energy systems involves multiple large time series such as energy demands and energy prices. Since problem size increases with the size of the time series, synthesis of energy systems leads to complex optimization problems. To reduce the problem size without loosing solution quality, we propose a method for time-series aggregation to identify typical periods. Typical periods retain the chronology of time steps, which enables modeling of energy systems, e.g., with storage units or start-up cost. The aim of the proposed method is to obtain few typical periods with few time steps per period, while accurately representing the objective function of the full time series, e.g., cost. Thus, we determine the error of time-series aggregation as the cost difference between operating the optimal design for the aggregated time series and for the full time series. Thereby, we rigorously bound the maximum performance loss of the optimal energy system design. In an initial step, the proposed method identifies the best length of typical periods by autocorrelation analysis. Subsequently, an adaptive procedure determines aggregated typical periods employing the clustering algorithm k-medoids, which groups similar periods into clusters and selects one representative period per cluster. Moreover, the number of time steps per period is aggregated by a novel clustering algorithm maintaining chronology of the time steps in the periods. The method is iteratively repeated until the error falls below a threshold value. A case study based on a real-world synthesis problem of an energy system shows that time-series aggregation from 8,760 time steps to 2 typical periods with each 2 time steps results in an error smaller than the optimality gap of

  12. Has Work Replaced Home as a Haven? Re-examining Arlie Hochschild's Time Bind Proposition with Objective Stress Data

    Science.gov (United States)

    Damaske, Sarah; Smyth, Joshua M.; Zawadzki, Matthew J.

    2014-01-01

    Using innovative data with objective and subjective measures of stress collected from 122 employed men and women, this paper tests the thesis of the Time Bind by asking whether people report lower stress levels at work than at home. The study finds consistent support for the Time Bind hypothesis when examining objective stress data: when participants were at work they had lower values of the stress hormone cortisol than when they were at home. Two variables moderated this association – income and children at home – such that the work as haven effect was stronger for those with lower incomes and no children living at home. Participants also, however, consistently reported higher subjective stress levels on work days than on non-work days, which is in direct contrast to the Time Bind hypothesis. Although our overall findings support Hochschild's hypothesis that stress levels are lower at work, it appears that combining work and home increases people's subjective experience of daily stress. PMID:24869785

  13. Has work replaced home as a haven? Re-examining Arlie Hochschild's Time Bind proposition with objective stress data.

    Science.gov (United States)

    Damaske, Sarah; Smyth, Joshua M; Zawadzki, Matthew J

    2014-08-01

    Using innovative data with objective and subjective measures of stress collected from 122 employed men and women, this paper tests the thesis of the Time Bind by asking whether people report lower stress levels at work than at home. The study finds consistent support for the Time Bind hypothesis when examining objective stress data: when participants were at work they had lower values of the stress hormone cortisol than when they were at home. Two variables moderated this association - income and children at home - such that the work as haven effect was stronger for those with lower incomes and no children living at home. Participants also, however, consistently reported higher subjective stress levels on work days than on non-work days, which is in direct contrast to the Time Bind hypothesis. Although our overall findings support Hochschild's hypothesis that stress levels are lower at work, it appears that combining work and home increases people's subjective experience of daily stress. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Lineage-Specific Real-Time RT-PCR for Yellow Fever Virus Outbreak Surveillance, Brazil.

    Science.gov (United States)

    Fischer, Carlo; Torres, Maria C; Patel, Pranav; Moreira-Soto, Andres; Gould, Ernest A; Charrel, Rémi N; de Lamballerie, Xavier; Nogueira, Rita Maria Ribeiro; Sequeira, Patricia C; Rodrigues, Cintia D S; Kümmerer, Beate M; Drosten, Christian; Landt, Olfert; Bispo de Filippis, Ana Maria; Drexler, Jan Felix

    2017-11-01

    The current yellow fever outbreak in Brazil prompted widespread yellow fever virus (YFV) vaccination campaigns, imposing a responsibility to distinguish between vaccine- and wild-type YFV-associated disease. We developed novel multiplex real-time reverse transcription PCRs that differentiate between vaccine and American wild-type YFV. We validated these highly specific and sensitive assays in an outbreak setting.

  15. Lineage-Specific Real-Time RT-PCR for Yellow Fever Virus Outbreak Surveillance, Brazil

    OpenAIRE

    Fischer, Carlo; Torres, Maria C.; Patel, Pranav; Moreira-Soto, Andres; Gould, Ernest A.; Charrel, Rémi N.; de Lamballerie, Xavier; Nogueira, Rita Maria Ribeiro; Sequeira, Patricia C.; Rodrigues, Cintia D.S.; Kümmerer, Beate M.; Drosten, Christian; Landt, Olfert; Bispo de Filippis, Ana Maria; Drexler, Jan Felix

    2017-01-01

    The current yellow fever outbreak in Brazil prompted widespread yellow fever virus (YFV) vaccination campaigns, imposing a responsibility to distinguish between vaccine- and wild-type YFV-associated disease. We developed novel multiplex real-time reverse transcription PCRs that differentiate between vaccine and American wild-type YFV. We validated these highly specific and sensitive assays in an outbreak setting.

  16. Non-specific Effects of Vaccines and Stunting: Timing May Be Essential

    NARCIS (Netherlands)

    Berendsen, M.L.T.; Smits, J.P.J.M.; Netea, M.G.; Ven, A.J.A.M. van der

    2016-01-01

    BACKGROUND - Bacillus Calmette-Guérin (BCG) vaccination possesses effects on health beyond its target disease, the so called “non-specific effects”. We evaluate these effects, as well as the effect of timing of BCG and other vaccinations, on stunting in Sub-Saharan African (SSA) children under

  17. Generalized Motor Abilities and Timing Behavior in Children with Specific Language Impairment

    Science.gov (United States)

    Zelaznik, Howard N.; Goffman, Lisa

    2010-01-01

    Purpose: To examine whether children with specific language impairment (SLI) differ from normally developing peers in motor skills, especially those skills related to timing. Method: Standard measures of gross and fine motor development were obtained. Furthermore, finger and hand movements were recorded while children engaged in 4 different timing…

  18. User-Defined Clocks in the Real-Time Specification for Java

    DEFF Research Database (Denmark)

    Wellings, Andy; Schoeberl, Martin

    2011-01-01

    This paper analyses the new user-defined clock model that is to be supported in Version 1.1 of the Real-Time Specification for Java (RTSJ). The model is a compromise between the current position, where there is no support for user-defined clocks, and a fully integrated model. The paper investigat...

  19. Comparative Analysis of Several Real-Time Systems for Tracking People and/or Moving Objects using GPS

    OpenAIRE

    Radinski, Gligorcho; Mileva, Aleksandra

    2015-01-01

    When we talk about real-time systems for tracking people and/or moving objects using a Global Positioning System (GPS), there are several categories of such systems and the ways in which they work. Some uses additional hardware to extend the functionality of the offered opportunities, some are free, some are too complex and cost too much money. This paper aims to provide a clearer picture of several such systems and to show results from a comparative analysis of some popular systems for trac...

  20. Patterns of objectively assessed physical activity and sedentary time: Are Nigerian health professional students complying with public health guidelines?

    Directory of Open Access Journals (Sweden)

    Adewale L Oyeyemi

    Full Text Available Understanding patterns of physical activity and sedentary time is important to effective population-wide primary prevention and control of non-communicable diseases. This study examined the patterns of objectively assessed physical activity and sedentary time, and the prevalence of compliance with physical activity guidelines according to different public health recommendations in a sub-population of health professional students in Nigeria.A cross-sectional study was conducted among 102 health professional students (age = 19-34 years old, 43.1% women of the University of Maiduguri, Nigeria. Participants wore Actigraph accelerometers on their waist for minimum of 5 days/week to objectively measure intensity and duration of physical activity and sedentary time. Prevalence and demographic patterns of physical activity and sedentary time were examined using descriptive and inferential statistics.The students spent most time in sedentary activity (458.6 ± minutes/day, about 61% of daily time and the least in vigorous-intensity activity (2.1 ± 4.4 minutes/day, about 0.3% of daily time. Sedentary time was higher among older than younger students (P<0.038 and among medical laboratory science students than physiotherapy and nursing students (P = 0.046. Total physical activity was higher among nursing and medical students than medical laboratory science students (P = 0.041. Although, 85.3% of the students engaged in 150 minutes/week of moderate-to-vigorous physical activity, only 2.9% met the guideline of 75 minutes/week of vigorous intensity activity.Prevalence of sedentary time was high while that of vigorous-intensity activity was very low among health professional students in Nigeria. Compliance with physical activity guidelines was mainly through accumulation of moderate intensity activity. The results suggest that age and academic programme may influence physical activity level and sedentary behaviour of health professional students in Nigeria

  1. Categorization for Faces and Tools—Two Classes of Objects Shaped by Different Experience—Differs in Processing Timing, Brain Areas Involved, and Repetition Effects

    Science.gov (United States)

    Kozunov, Vladimir; Nikolaeva, Anastasia; Stroganova, Tatiana A.

    2018-01-01

    The brain mechanisms that integrate the separate features of sensory input into a meaningful percept depend upon the prior experience of interaction with the object and differ between categories of objects. Recent studies using representational similarity analysis (RSA) have characterized either the spatial patterns of brain activity for different categories of objects or described how category structure in neuronal representations emerges in time, but never simultaneously. Here we applied a novel, region-based, multivariate pattern classification approach in combination with RSA to magnetoencephalography data to extract activity associated with qualitatively distinct processing stages of visual perception. We asked participants to name what they see whilst viewing bitonal visual stimuli of two categories predominantly shaped by either value-dependent or sensorimotor experience, namely faces and tools, and meaningless images. We aimed to disambiguate the spatiotemporal patterns of brain activity between the meaningful categories and determine which differences in their processing were attributable to either perceptual categorization per se, or later-stage mentalizing-related processes. We have extracted three stages of cortical activity corresponding to low-level processing, category-specific feature binding, and supra-categorical processing. All face-specific spatiotemporal patterns were associated with bilateral activation of ventral occipito-temporal areas during the feature binding stage at 140–170 ms. The tool-specific activity was found both within the categorization stage and in a later period not thought to be associated with binding processes. The tool-specific binding-related activity was detected within a 210–220 ms window and was located to the intraparietal sulcus of the left hemisphere. Brain activity common for both meaningful categories started at 250 ms and included widely distributed assemblies within parietal, temporal, and prefrontal regions

  2. Categorization for Faces and Tools-Two Classes of Objects Shaped by Different Experience-Differs in Processing Timing, Brain Areas Involved, and Repetition Effects.

    Science.gov (United States)

    Kozunov, Vladimir; Nikolaeva, Anastasia; Stroganova, Tatiana A

    2017-01-01

    The brain mechanisms that integrate the separate features of sensory input into a meaningful percept depend upon the prior experience of interaction with the object and differ between categories of objects. Recent studies using representational similarity analysis (RSA) have characterized either the spatial patterns of brain activity for different categories of objects or described how category structure in neuronal representations emerges in time, but never simultaneously. Here we applied a novel, region-based, multivariate pattern classification approach in combination with RSA to magnetoencephalography data to extract activity associated with qualitatively distinct processing stages of visual perception. We asked participants to name what they see whilst viewing bitonal visual stimuli of two categories predominantly shaped by either value-dependent or sensorimotor experience, namely faces and tools, and meaningless images. We aimed to disambiguate the spatiotemporal patterns of brain activity between the meaningful categories and determine which differences in their processing were attributable to either perceptual categorization per se , or later-stage mentalizing-related processes. We have extracted three stages of cortical activity corresponding to low-level processing, category-specific feature binding, and supra-categorical processing. All face-specific spatiotemporal patterns were associated with bilateral activation of ventral occipito-temporal areas during the feature binding stage at 140-170 ms. The tool-specific activity was found both within the categorization stage and in a later period not thought to be associated with binding processes. The tool-specific binding-related activity was detected within a 210-220 ms window and was located to the intraparietal sulcus of the left hemisphere. Brain activity common for both meaningful categories started at 250 ms and included widely distributed assemblies within parietal, temporal, and prefrontal regions

  3. Opposition multiple objective symbiotic organisms search (OMOSOS for time, cost, quality and work continuity tradeoff in repetitive projects

    Directory of Open Access Journals (Sweden)

    Duc-Hoc Tran

    2018-04-01

    Full Text Available Construction managers often face with projects containing multiple units wherein activities repeat from unit to unit. Therefore effective resource management is crucial in terms of project duration, cost and quality. Accordingly, researchers have developed several models to aid planners in developing practical and near-optimal schedules for repetitive projects. Despite their undeniable benefits, such models lack the ability of pure simultaneous optimization because existing methodologies optimize the schedule with respect to a single factor, to achieve minimum duration, total cost, resource work breaks or various combinations, respectively. This study introduces a novel approach called “opposition multiple objective symbiotic organisms search” (OMOSOS for scheduling repetitive projects. The proposed algorithm used an opposition-based learning technique for population initialization and for generation jumping. Further, this study integrated a scheduling module (M1 to determine all project objectives including time, cost, quality and interruption. The proposed algorithm was implemented on two application examples in order to demonstrate its capabilities in optimizing the scheduling of repetitive construction projects. The results indicate that the OMOSOS approach is a powerful optimization technique and can assist project managers in selecting appropriate plan for project. Keywords: Symbiotic organisms search, Multi-objective analysis, Resource tradeoff, Schedules, Repetitive

  4. MULTILOOP PI CONTROLLER FOR ACHIEVING SIMULTANEOUS TIME AND FREQUENCY DOMAIN SPECIFICATIONS

    Directory of Open Access Journals (Sweden)

    M. SENTHILKUMAR

    2015-08-01

    Full Text Available Most of the controllers in control system are designed to satisfy either time domain or frequency domain specifications. This work presents the computation of a multiloop PI controller for achieving time and frequency domain specifications simultaneously. The desired time and frequency domain measures are to be specified initially to the design. To obtain the desired value of the performance measures the graphical relationship between the PI controller and the performance criteria is given. Thus by using graphical method a set of PI controller parameters to meet the desired performance measures are obtained in an effective and simpler way. The coupled tank has become a classic design of control engineering for multivariable process. The proposed control strategy has been implemented in the same coupled tank process and validated through simulation studies.

  5. Objeto e desejo em tempos de superexposição Object and desire in times of super exposure

    Directory of Open Access Journals (Sweden)

    Marcus André Vieira

    2005-01-01

    Full Text Available Interroga-se a tristeza a partir da retomada lacaniana da teorização do luto por Freud. Delimitam-se, a seguir, as bases de uma teoria lacaniana da perda, localizando a importância do objeto a e destacando-se sua função de causa do desejo. Situa-se a dor da perda em relação com a perda da função do objeto, causa do desejo, necessariamente vinculada à inacessibilidade do objeto. Aborda-se a contemporaneidade com a seguinte questão: é possível que o objeto tenha se tornado visível/acessível? Isto não implicaria em instabilidades radicais na estruturação do imaginário do corpo? Objeto e desejo em tempos de superexposição.It is questioned the sadness from the Lacanian resume of the mourning theorization by Freud. It is determined, afterwards, the bases of a Lacanian theory of loss, pin pointing the importance of the object a, and setting apart its function of desire motive. It is found the pain of the loss in relation to the loss of function of the object motive of the desire. The contemporarily is approached in the following questions: Is it possible for the object to have become visible/accessible? Wouldn't that implicate in radical instability in the building of the imaginary body? Object and desire in times of super exposure.

  6. Category-Specific Visual Recognition and Aging from the PACE Theory Perspective: Evidence for a Presemantic Deficit in Aging Object Recognition

    DEFF Research Database (Denmark)

    Bordaberry, Pierre; Gerlach, Christian; Lenoble, Quentin

    2016-01-01

    Background/Study Context: The objective of this study was to investigate the object recognition deficit in aging. Age-related declines were examined from the presemantic account of category effects (PACE) theory perspective (Gerlach, 2009, Cognition, 111, 281–301). This view assumes that the stru......Background/Study Context: The objective of this study was to investigate the object recognition deficit in aging. Age-related declines were examined from the presemantic account of category effects (PACE) theory perspective (Gerlach, 2009, Cognition, 111, 281–301). This view assumes...... that the structural similarity/dissimilarity inherent in living and nonliving objects, respectively, can account for a wide range of category-specific effects. Methods: In two experiments on object recognition, young (36 participants, 18–27 years) and older (36 participants, 53–69 years) adult participants...... in the selection stage of the PACE theory (visual long-term memory matching) could be responsible for these impairments. Indeed, the older group showed a deficit when this stage was most relevant. This article emphasize on the critical need for taking into account structural component of the stimuli and type...

  7. Generalized motor abilities and timing behavior in children with specific language impairment.

    Science.gov (United States)

    Zelaznik, Howard N; Goffman, Lisa

    2010-04-01

    To examine whether children with specific language impairment (SLI) differ from normally developing peers in motor skills, especially those skills related to timing. Standard measures of gross and fine motor development were obtained. Furthermore, finger and hand movements were recorded while children engaged in 4 different timing tasks, including tapping and drawing circles in time with a metronome or a visual target. Fourteen children with SLI (age 6 to 8 years) and 14 age-matched peers who were typically developing participated. As expected, children with SLI showed poorer performance on a standardized test of gross and fine motor skill than did their normally developing peers. However, timing skill in the manual domain was equivalent to that seen in typically developing children. Consistent with earlier findings, relatively poor gross and fine motor performance is observed in children with SLI. Surprisingly, rhythmic timing is spared.

  8. Objective assessment of drowsiness and reaction time during intermittent Ramadan fasting in young men: a case-crossover study.

    Science.gov (United States)

    Bahammam, Ahmed S; Nashwan, Samar; Hammad, Omeima; Sharif, Munir M; Pandi-Perumal, Seithikurippu R

    2013-08-12

    Ramadan fasting and its attendant lifestyle changes induce changes in the circadian rhythm and in associated physiological and metabolic functions. Previous studies that have assessed psychomotor performance during Ramadan fasting have reported conflicting results. Therefore, we designed this study to objectively assess the effects of intermittent fasting during and outside Ramadan (to control for lifestyle changes) on drowsiness, blink total duration and mean reaction time (MRT) test while controlling for potential confounders. Eight healthy volunteers with a mean age of 25.3 ± 2.9 years and a mean body mass index (BMI) of 23.4 ± 3.2 kg/m2 reported to the sleep laboratory on four occasions for polysomnography (PSG) and drowsiness and psychomotor assessments as follows: 1) adaptation; 2) 4 weeks before Ramadan while performing the Islamic fasting for 1 week (baseline fasting) (BLF); 3) 1 week before Ramadan (non-fasting baseline) (BL); and 4) during the second week of Ramadan while fasting (Ramadan). OPTALERT™ was used to objectively assess daytime drowsiness using the Johns Drowsiness Scale (JDS), and blink total duration and a visual reaction time test were used to assess MRT. Rapid eye movement (REM) sleep percentage was significantly lower at BLF (17.7 ± 8.1%) and at Ramadan (18.6 ± 10.7%) compared with BL (25.6 ± 4.8%) (p intermittent fasting has no impact on drowsiness and vigilance as measured by the JDS, total blink duration and MRT.

  9. On the health paradox of occupational and leisure-time physical activity using objective measurements: Effects on autonomic imbalance.

    Directory of Open Access Journals (Sweden)

    David M Hallman

    Full Text Available Leisure-time physical activity (LTPA has considerable benefits for cardiovascular health and longevity, while occupational physical activity (OPA is associated with an elevated cardiovascular risk. This "health paradox" may be explained by different effects on the autonomic nervous system from OPA and LTPA. Thus, we aimed to investigate whether objectively measured OPA and LTPA are differentially associated with autonomic regulation among workers.The study comprised 514 blue-collar workers from the Danish cohort DPHACTO. Physical activity (i.e. walking, climbing stairs, running and cycling was assessed objectively using accelerometers worn on the thigh, hip and trunk over multiple working days. During this period, a heart rate monitor was used to sample heart period intervals from the ECG signal. Heart rate and heart rate variability (HRV indices were analyzed during nocturnal sleep as markers of autonomic regulation. Multiple regression analysis was used to determine the main effects of OPA and LTPA and their interaction on heart rate and HRV, adjusting for multiple confounders.Statistically significant interaction was found between OPA and LTPA on heart rate (adjusted p<0.0001 and HRV indices in time (rMSSD, adjusted p = 0.004 and frequency-domains (HF, adjusted p = 0.022; LF, adjusted p = 0.033. The beneficial effect of LTPA on nocturnal heart rate and HRV clearly diminished with higher levels of OPA, and high levels of both OPA and LTPA had a detrimental effect.We found contrasting associations for objectively measured OPA and LTPA with heart rate and HRV during sleep. Differential effects of OPA and LTPA on autonomic regulation may contribute to the physical activity health paradox.

  10. Time-domain full waveform inversion of exponentially damped wavefield using the deconvolution-based objective function

    KAUST Repository

    Choi, Yun Seok

    2017-11-15

    Full waveform inversion (FWI) suffers from the cycle-skipping problem when the available frequency-band of data is not low enough. We apply an exponential damping to the data to generate artificial low frequencies, which helps FWI avoid cycle skipping. In this case, the least-square misfit function does not properly deal with the exponentially damped wavefield in FWI, because the amplitude of traces decays almost exponentially with increasing offset in a damped wavefield. Thus, we use a deconvolution-based objective function for FWI of the exponentially damped wavefield. The deconvolution filter includes inherently a normalization between the modeled and observed data, thus it can address the unbalanced amplitude of a damped wavefield. We, specifically, normalize the modeled data with the observed data in the frequency-domain to estimate the deconvolution filter and selectively choose a frequency-band for normalization that mainly includes the artificial low frequencies. We calculate the gradient of the objective function using the adjoint-state method. The synthetic and benchmark data examples show that our FWI algorithm generates a convergent long wavelength structure without low frequency information in the recorded data.

  11. Time-domain full waveform inversion of exponentially damped wavefield using the deconvolution-based objective function

    KAUST Repository

    Choi, Yun Seok; Alkhalifah, Tariq Ali

    2017-01-01

    Full waveform inversion (FWI) suffers from the cycle-skipping problem when the available frequency-band of data is not low enough. We apply an exponential damping to the data to generate artificial low frequencies, which helps FWI avoid cycle skipping. In this case, the least-square misfit function does not properly deal with the exponentially damped wavefield in FWI, because the amplitude of traces decays almost exponentially with increasing offset in a damped wavefield. Thus, we use a deconvolution-based objective function for FWI of the exponentially damped wavefield. The deconvolution filter includes inherently a normalization between the modeled and observed data, thus it can address the unbalanced amplitude of a damped wavefield. We, specifically, normalize the modeled data with the observed data in the frequency-domain to estimate the deconvolution filter and selectively choose a frequency-band for normalization that mainly includes the artificial low frequencies. We calculate the gradient of the objective function using the adjoint-state method. The synthetic and benchmark data examples show that our FWI algorithm generates a convergent long wavelength structure without low frequency information in the recorded data.

  12. Self-efficacy for exercise, more than disease-related factors, is associated with objectively assessed exercise time and sedentary behaviour in rheumatoid arthritis.

    Science.gov (United States)

    Huffman, K M; Pieper, C F; Hall, K S; St Clair, E W; Kraus, W E

    2015-01-01

    Until recently, reports of physical activity in rheumatoid arthritis (RA) were limited to self-report methods and/or leisure-time physical activity. Our objectives were to assess, determine correlates of, and compare to well-matched controls both exercise and sedentary time in a typical clinical cohort of RA. Persons with established RA (seropositive or radiographic erosions; n = 41) without diabetes or cardiovascular disease underwent assessments of traditional and disease-specific correlates of physical activity and 7 days of triaxial accelerometry. Twenty-seven age, gender, and body mass index (BMI)-matched controls were assessed. For persons with RA, objectively measured median (25th-75th percentile) exercise time was 3 (1-11) min/day; only 10% (n = 4) of participants exercised for ≥ 30 min/day. Time spent in sedentary activities was 92% (89-95%). Exercise time was not related to pain but was inversely related to disease activity (r = -0.3, p self-efficacy for endurance activity (r = 0.4, p self-efficacy for endurance activity (r = -0.4, p self-efficacy for physical activity but similar amounts of exercise and sedentary time. For persons with RA and without diabetes or cardiovascular disease, time spent in exercise was well below established guidelines and activity patterns were predominantly sedentary. For optimal care in RA, in addition to promoting exercise, clinicians should consider assessing sedentary behaviour and self-efficacy for exercise. Future interventions might determine whether increased self-efficacy can increase physical activity in RA.

  13. Finite-time convergent recurrent neural network with a hard-limiting activation function for constrained optimization with piecewise-linear objective functions.

    Science.gov (United States)

    Liu, Qingshan; Wang, Jun

    2011-04-01

    This paper presents a one-layer recurrent neural network for solving a class of constrained nonsmooth optimization problems with piecewise-linear objective functions. The proposed neural network is guaranteed to be globally convergent in finite time to the optimal solutions under a mild condition on a derived lower bound of a single gain parameter in the model. The number of neurons in the neural network is the same as the number of decision variables of the optimization problem. Compared with existing neural networks for optimization, the proposed neural network has a couple of salient features such as finite-time convergence and a low model complexity. Specific models for two important special cases, namely, linear programming and nonsmooth optimization, are also presented. In addition, applications to the shortest path problem and constrained least absolute deviation problem are discussed with simulation results to demonstrate the effectiveness and characteristics of the proposed neural network.

  14. Countermovement jump height: gender and sport-specific differences in the force-time variables.

    Science.gov (United States)

    Laffaye, Guillaume; Wagner, Phillip P; Tombleson, Tom I L

    2014-04-01

    The goal of this study was to assess (a) the eccentric rate of force development, the concentric force, and selected time variables on vertical performance during countermovement jump, (b) the existence of gender differences in these variables, and (c) the sport-specific differences. The sample was composed of 189 males and 84 females, all elite athletes involved in college and professional sports (primarily football, basketball, baseball, and volleyball). The subjects performed a series of 6 countermovement jumps on a force plate (500 Hz). Average eccentric rate of force development (ECC-RFD), total time (TIME), eccentric time (ECC-T), Ratio between eccentric and total time (ECC-T:T) and average force (CON-F) were extracted from force-time curves and the vertical jumping performance, measured by impulse momentum. Results show that CON-F (r = 0.57; p differ between both sexes (p differ, showing a similar temporal structure. The best way to jump high is to increase CON-F and ECC-RFD thus minimizing the ECC-T. Principal component analysis (PCA) accounted for 76.8% of the JH variance and revealed that JH is predicted by a temporal and a force component. Furthermore, the PCA comparison made among athletes revealed sport-specific signatures: volleyball players revealed a temporal-prevailing profile, a weak-force with large ECC-T:T for basketball players and explosive and powerful profiles for football and baseball players.

  15. Human active X-specific DNA methylation events showing stability across time and tissues

    Science.gov (United States)

    Joo, Jihoon Eric; Novakovic, Boris; Cruickshank, Mark; Doyle, Lex W; Craig, Jeffrey M; Saffery, Richard

    2014-01-01

    The phenomenon of X chromosome inactivation in female mammals is well characterised and remains the archetypal example of dosage compensation via monoallelic expression. The temporal series of events that culminates in inactive X-specific gene silencing by DNA methylation has revealed a ‘patchwork' of gene inactivation along the chromosome, with approximately 15% of genes escaping. Such genes are therefore potentially subject to sex-specific imbalance between males and females. Aside from XIST, the non-coding RNA on the X chromosome destined to be inactivated, very little is known about the extent of loci that may be selectively silenced on the active X chromosome (Xa). Using longitudinal array-based DNA methylation profiling of two human tissues, we have identified specific and widespread active X-specific DNA methylation showing stability over time and across tissues of disparate origin. Our panel of X-chromosome loci subject to methylation on Xa reflects a potentially novel mechanism for controlling female-specific X inactivation and sex-specific dimorphisms in humans. Further work is needed to investigate these phenomena. PMID:24713664

  16. Context-specific outdoor time and physical activity among school-children across gender and age: Using accelerometers and GPS to advance methods

    Directory of Open Access Journals (Sweden)

    Charlotte Demant Klinker

    2014-03-01

    Full Text Available Introduction: Being outdoors has a positive influence on health among children. Evidence in this area is limited and many studies have used self-reported measures. Objective context-specific assessment of physical activity patterns and correlates, such as outdoor time, may progress this field.Aims: To employ novel objective measures to assess age and gender differences in context-specific outdoor weekday behavior patterns among school-children (outdoor time and outdoor MVPA and to investigate associations between context-specific outdoor time and MVPA.Methods: A total of 170 children had at least one weekday of nine hours combined accelerometer and GPS data and were included in the analyses. The data were processed using the Personal Activity and Location Measurement System and a purpose-built PostgreSQL database resulting in context-specific measures for outdoor time, outdoor MVPA and overall daily MVPA. In addition, four domains (leisure, school, transport and home and 11 subdomains (e.g. urban green space, sports facilities were created and assessed. Multilevel analyses provided results on age and gender differences and the association between outdoor time and MVPA.Results: Girls compared to boys had fewer outdoors minutes (pConclusion:A new methodology to assess context-specific outdoor time and physical activity patterns has been developed and can be expanded to other populations. Different context-specific patterns were found for gender and age, suggesting different strategies may be needed to promote physical activity

  17. The impact of technical specification surveillance requirements and allowable outage times on plant availability

    International Nuclear Information System (INIS)

    Webster, S.A.; Finnicum, D.J.

    1985-01-01

    Surveillances required to be conducted by a plant's Technical Specifications have resulted in plant shutdowns and lost availability. This paper looks at shutdowns which have occurred due to required surveillance testing and insufficient repair time allowed by Technical Specifications. A loss of plant availability of almost 3% per plant year was found for U.S. pressurized water reactors during the five year period, 1979 to 1984. This figure excludes major problems which required plant shutdown whether or not mandated by the Technical Specifications. In addition to their affect on availability, such shutdowns can add to the challenges to plant safety systems and can affect plant aging by increasing the thermal cycles on plant components

  18. Prostate-specific antigen doubling time as a progression criterion in an active surveillance programme for patients with localized prostate cancer

    DEFF Research Database (Denmark)

    Thomsen, Frederik Birkebaek; Christensen, Ib Jarle; Brasso, Klaus

    2014-01-01

    OBJECTIVES: To elucidate the role of prostate-specific antigen (PSA) doubling time (PSAdt) as a progression criterion in patients with low-risk prostate cancer managed by active surveillance (AS). To assess the correlation between PSAdt during AS and final histopathology after radical prostatectomy...

  19. Design of the real time systems using temporal logic specifications: a case study

    Directory of Open Access Journals (Sweden)

    A. Ursu

    1996-07-01

    Full Text Available An implementation method for real time systems is proposed in this article. The implementation starts with the design of the functional specifications of the systems behaviour. The functional specifications are introduced as a set of rules describing the partial time ordering of the actions performed by the system. These rules are then written in terms of temporal logic formulae. The temporal logic formulae are checked using Z.Manna-P.Wolper satisfiability analysis procedure [1]. It is known that this procedure generates a state-graph which can be regarded as a state- based automaton of the system. The sate-based automaton is used then to generate the dual (inverted automaton of the system. The dual automaton is called action-based automaton and can be created using the procedure proposed by authors in [4,5]. Using the action-based automaton of the system the design method introduced in [5,6] is applied to implement the system driver in a systematic manner which can be computerised. The method proposed in this paper is an efficient complementation and generalisation of the results [4,5,6] mentioned above. The method is used for a case study. An elevator control system is designed using the proposed method. The design is carried out in a systematic manner which includes: a design of functional specifications, b design of temporal logic specifications, c satisfiability analysis of temporal logic specifications, d design of the state-based automaton of the specifications, e design of the action-based automaton of the system, f design of the transition activation conditions, g design of the action activation conditions, h design of the functional model of the elevator control system, i implementation of the elevator's actions, j design of the elevator control system driver.

  20. Observations of pretreatment prostate-specific antigen doubling time in 107 patients referred for definitive radiotherapy

    International Nuclear Information System (INIS)

    Lee, W. Robert; Hanks, Gerald E.; Corn, Benjamin W.; Schultheiss, Timothy E.

    1995-01-01

    Purpose: To determine pretreatment prostate-specific antigen doubling times (PSADT) in patients referred for definitive radiotherapy. Methods and Materials: One hundred and seven patients with histologically proven nonmetastatic prostate cancer and an elevated prostate-specific antigen (PSA) who were referred for radiation therapy had three serum PSA values obtained prior to the start of definitive therapy. Prostate-specific antigen doubling times were calculated by linear regression. Results: Prostate-specific antigen values increased during the period of observation in 78 patients (73%). Forty-three patients (40%) had calculated PSADT of less than 2 years and of those patients with pretreatment serum PSA values of greater than 10 ng/mL more than 50% has calculated PSADT of less than 2 years. Conclusions: A significant minority of patients referred for radiotherapy have calculated PSADT of less than 2 years. The significance of this relatively fast growth rate is as yet undetermined, but suggests that patients referred for radiotherapy may have aggressive disease prior to treatment

  1. Effect of Half Time Cooling on Thermoregulatory Responses and Soccer-Specific Performance Tests

    OpenAIRE

    Yang Zhang; Svetlana Nepocatych; Charlie P. Katica; Annie B. Collins,; Catalina Casaru,; Gytis Balilionis; Jesper Sjökvist; Phillip A. Bishop

    2014-01-01

    This study examined two active coolings (forearm and hand cooling, and neck cooling) during a simulated half-time recovery on thermoregulatory responses and subsequent soccer-specific exercise performance. Following a 45-min treadmill run in the heat, participants (N=7) undertook 15-min recovery with either passive cooling, forearm and hand cooling, or neck cooling in a simulated cooled locker room environment. After the recovery, participants performed a 6×15-m sprint test and Yo-Yo Intermit...

  2. Specification and testing of Multiplicative Time-Varying GARCH models with applications

    DEFF Research Database (Denmark)

    Amado, Cristina; Teräsvirta, Timo

    2017-01-01

    In this article, we develop a specification technique for building multiplicative time-varying GARCH models of Amado and Teräsvirta (2008, 2013). The variance is decomposed into an unconditional and a conditional component such that the unconditional variance component is allowed to evolve smooth...... is illustrated in practice with two real examples: an empirical application to daily exchange rate returns and another one to daily coffee futures returns....

  3. Chinese and Australians showed difference in mental time travel in emotion and content but not specificity

    Directory of Open Access Journals (Sweden)

    Xing-jie eChen

    2015-06-01

    Full Text Available Mental time travel refers to the ability to recall episodic past and imagine future events. The present study aimed to investigate cultural differences in mental time travel between Chinese and Australian university students. A total of 231 students (108 Chinese & 123 Australians participated in the study. Their mental time travel abilities were measured by the Sentence Completion for Events from the Past Test (SCEPT and the Sentence Completion for Events in the Future Test (SCEFT. Results showed that there were no cultural differences in the number of specific events generated for the past or future. Significant differences between the Chinese and Australian participants were found mainly in the emotional valence and content of the events generated. Both Chinese and Australian participants generated more specific positive events compared to negative events when thinking about the future and Chinese participants were more positive about their past than Australian participants when recalled specific events. For content, Chinese participants recalled more events about their interpersonal relationships, while Australian participants imagined more about personal future achievements. These findings shed some lights on cultural differences in episodic past and future thinking.

  4. Pretreatment prostate-specific antigen doubling times: clinical utility of this predictor of prostate cancer behavior

    International Nuclear Information System (INIS)

    Hanks, Gerald E.; Hanlon, Alexandra L.; Lee, W. Robert; Slivjak, Anne; Schultheiss, Timothy E.

    1996-01-01

    Purpose: The distribution of pretreatment and posttreatment prostate specific antigen (PSA) doubling times (PSADT) varies widely. This report examines the pretreatment PSADT as an independent predictor of biochemical freedom from disease (bNED) and describes the clinical utility of PSADT. Methods and Materials: Ninety-nine patients with T1-3 NX, M-0 prostate cancer treated between February 1989 and November 1993 have pretreatment PSADTs calculated from three or more PSA levels. Biochemical disease-free (bNED) survival (failure is PSA ≥ 1.5 ngm/ml and rising) is evaluated by multivariate analysis of common prognostic indicators and PSADT. Results: Prostate-specific antigen doubling time (PSADT) is a significant predictor of survival along with radiation dose. Patients with a pretreatment PSADT of < 12 months show 50% failure by 18 months, while those with a PSADT that is not increasing show only 3% failure at 3 years. Conclusions: Prostate-specific antigen doubling time (PSADT) is a predictor of bNED outcome in prostate cancer. Patients with PSADT < 12 months have aggressive disease and should be considered for multimodal therapy. Slow PSADT (≥ 5 years) is observed in 57% of patients, and this end point may be considered in the decision to observe rather than to treat. After treatment failure, the PSADT may be used to determine which patients do not need immediate androgen deprivation

  5. Can Previewing Sport-Specific Video Influence Reactive-Agility Response Time?

    Science.gov (United States)

    Holding, Ryan; Meir, Rudi; Zhou, Shi

    2017-02-01

    The purpose of this study was to examine whether a video-based warm-up could provide an acute performance benefit to response time for athletes in a sport-specific agility task. In addition, 2 learning strategies, explicit and implicit, were compared for their effectiveness in facilitating an improvement in sport-specific agility. Thirty representative male junior rugby union players (age 14-16 y, mean age 14.6 ± 1.09 y) were placed in 3 experimental groups (explicit, implicit, and control) and completed 2 intervention sessions. Testing sessions included preintervention testing, completion of the video-based warm-up intervention, and postintervention testing. A 3D motion-analysis system was used to assess response time in the testing battery. The athletes' response times on the pre- to postintervention tests were compared to determine the effectiveness of the video-based warm-up. A 2-way general linear model with repeated-measures analysis indicated that both the explicit (P = .030, d = 0.28) and implicit (P = .049, d = 0.33) groups significantly improved their response time by the intervention compared with the control group (P = .367, d = 0.08). The mean postintervention response time for the explicit group improved by 19.1% (from 0.246 s pre to 0.199 s post), and the implicit group improved by 15.7% (from 0.268 s to 0.226 s). Findings suggest that a video-based warm-up may provide an acute benefit to sport-specific agility performance for junior athletes.

  6. Herschel Observations of Protostellar and Young Stellar Objects in Nearby Molecular Clouds: The DIGIT Open Time Key Project

    Science.gov (United States)

    Green, Joel D.; DIGIT OTKP Team

    2010-01-01

    The DIGIT (Dust, Ice, and Gas In Time) Open Time Key Project utilizes the PACS spectrometer (57-210 um) onboard the Herschel Space Observatory to study the colder regions of young stellar objects and protostellar cores, complementary to recent observations from Spitzer and ground-based observatories. DIGIT focuses on 30 embedded sources and 64 disk sources, and includes supporting photometry from PACS and SPIRE, as well as spectroscopy from HIFI, selected from nearby molecular clouds. For the embedded sources, PACS spectroscopy will allow us to address the origin of [CI] and high-J CO lines observed with ISO-LWS. Our observations are sensitive to the presence of cold crystalline water ice, diopside, and carbonates. Additionally, PACS scans are 5x5 maps of the embedded sources and their outflows. Observations of more evolved disk sources will sample low and intermediate mass objects as well as a variety of spectral types from A to M. Many of these sources are extremely rich in mid-IR crystalline dust features, enabling us to test whether similar features can be detected at larger radii, via colder dust emission at longer wavelengths. If processed grains are present only in the inner disk (in the case of full disks) or from the emitting wall surface which marks the outer edge of the gap (in the case of transitional disks), there must be short timescales for dust processing; if processed grains are detected in the outer disk, radial transport must be rapid and efficient. Weak bands of forsterite and clino- and ortho-enstatite in the 60-75 um range provide information about the conditions under which these materials were formed. For the Science Demonstration Phase we are observing an embedded protostar (DK Cha) and a Herbig Ae/Be star (HD 100546), exemplars of the kind of science that DIGIT will achieve over the full program.

  7. Edge smoothing for real-time simulation of a polygon face object system as viewed by a moving observer

    Science.gov (United States)

    Lotz, Robert W. (Inventor); Westerman, David J. (Inventor)

    1980-01-01

    The visual system within an aircraft flight simulation system receives flight data and terrain data which is formated into a buffer memory. The image data is forwarded to an image processor which translates the image data into face vertex vectors Vf, defining the position relationship between the vertices of each terrain object and the aircraft. The image processor then rotates, clips, and projects the image data into two-dimensional display vectors (Vd). A display generator receives the Vd faces, and other image data to provide analog inputs to CRT devices which provide the window displays for the simulated aircraft. The video signal to the CRT devices passes through an edge smoothing device which prolongs the rise time (and fall time) of the video data inversely as the slope of the edge being smoothed. An operational amplifier within the edge smoothing device has a plurality of independently selectable feedback capacitors each having a different value. The values of the capacitors form a series which doubles as a power of two. Each feedback capacitor has a fast switch responsive to the corresponding bit of a digital binary control word for selecting (1) or not selecting (0) that capacitor. The control word is determined by the slope of each edge. The resulting actual feedback capacitance for each edge is the sum of all the selected capacitors and is directly proportional to the value of the binary control word. The output rise time (or fall time) is a function of the feedback capacitance, and is controlled by the slope through the binary control word.

  8. Using recruitment source timing and diagnosticity to enhance applicants' occupation-specific human capital.

    Science.gov (United States)

    Campion, Michael C; Ployhart, Robert E; Campion, Michael A

    2017-05-01

    [Correction Notice: An Erratum for this article was reported in Vol 102(5) of Journal of Applied Psychology (see record 2017-14296-001). In the article, the following headings were inadvertently set at the wrong level: Method, Participants and Procedure, Measures, Occupation specific human capital, Symbolic jobs, Relevant majors, Occupation-specific capital hotspots, Source timing, Source diagnosticity, Results, and Discussion. All versions of this article have been corrected.] This study proposes that reaching applicants through more diagnostic recruitment sources earlier in their educational development (e.g., in high school) can lead them to invest more in their occupation-specific human capital (OSHC), thereby making them higher quality candidates. Using a sample of 78,157 applicants applying for jobs within a desirable professional occupation in the public sector, results indicate that applicants who report hearing about the occupation earlier, and applicants who report hearing about the occupation through more diagnostic sources, have higher levels of OSHC upon application. Additionally, source timing and diagnosticity affect the likelihood of candidates applying for jobs symbolic of the occupation, selecting relevant majors, and attending educational institutions with top programs related to the occupation. These findings suggest a firm's recruiting efforts may influence applicants' OSHC investment strategies. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  9. GETPrime: a gene- or transcript-specific primer database for quantitative real-time PCR.

    Science.gov (United States)

    Gubelmann, Carine; Gattiker, Alexandre; Massouras, Andreas; Hens, Korneel; David, Fabrice; Decouttere, Frederik; Rougemont, Jacques; Deplancke, Bart

    2011-01-01

    The vast majority of genes in humans and other organisms undergo alternative splicing, yet the biological function of splice variants is still very poorly understood in large part because of the lack of simple tools that can map the expression profiles and patterns of these variants with high sensitivity. High-throughput quantitative real-time polymerase chain reaction (qPCR) is an ideal technique to accurately quantify nucleic acid sequences including splice variants. However, currently available primer design programs do not distinguish between splice variants and also differ substantially in overall quality, functionality or throughput mode. Here, we present GETPrime, a primer database supported by a novel platform that uniquely combines and automates several features critical for optimal qPCR primer design. These include the consideration of all gene splice variants to enable either gene-specific (covering the majority of splice variants) or transcript-specific (covering one splice variant) expression profiling, primer specificity validation, automated best primer pair selection according to strict criteria and graphical visualization of the latter primer pairs within their genomic context. GETPrime primers have been extensively validated experimentally, demonstrating high transcript specificity in complex samples. Thus, the free-access, user-friendly GETPrime database allows fast primer retrieval and visualization for genes or groups of genes of most common model organisms, and is available at http://updepla1srv1.epfl.ch/getprime/. Database URL: http://deplanckelab.epfl.ch.

  10. Time-trends in method-specific suicide rates compared with the availability of specific compounds. The Danish experience

    DEFF Research Database (Denmark)

    Nordentoft, Merete; Qin, Ping; Helweg-Larsen, Karin

    2006-01-01

    Restriction of means for suicide is an important part of suicide preventive strategies in different countries. All suicides in Denmark between 1970 and 2000 were examined with regard to method used for suicide. Overall suicide mortality and method-specific suicide mortality was compared...... in the number of suicides by self-poisoning with these compounds. Restricted access occurred concomittantly with a 55% decrease in suicide rate...

  11. MULTIPLE OBJECTS

    Directory of Open Access Journals (Sweden)

    A. A. Bosov

    2015-04-01

    Full Text Available Purpose. The development of complicated techniques of production and management processes, information systems, computer science, applied objects of systems theory and others requires improvement of mathematical methods, new approaches for researches of application systems. And the variety and diversity of subject systems makes necessary the development of a model that generalizes the classical sets and their development – sets of sets. Multiple objects unlike sets are constructed by multiple structures and represented by the structure and content. The aim of the work is the analysis of multiple structures, generating multiple objects, the further development of operations on these objects in application systems. Methodology. To achieve the objectives of the researches, the structure of multiple objects represents as constructive trio, consisting of media, signatures and axiomatic. Multiple object is determined by the structure and content, as well as represented by hybrid superposition, composed of sets, multi-sets, ordered sets (lists and heterogeneous sets (sequences, corteges. Findings. In this paper we study the properties and characteristics of the components of hybrid multiple objects of complex systems, proposed assessments of their complexity, shown the rules of internal and external operations on objects of implementation. We introduce the relation of arbitrary order over multiple objects, we define the description of functions and display on objects of multiple structures. Originality.In this paper we consider the development of multiple structures, generating multiple objects.Practical value. The transition from the abstract to the subject of multiple structures requires the transformation of the system and multiple objects. Transformation involves three successive stages: specification (binding to the domain, interpretation (multiple sites and particularization (goals. The proposed describe systems approach based on hybrid sets

  12. A closure test for time-specific capture-recapture data

    Science.gov (United States)

    Stanley, T.R.; Burnham, K.P.

    1999-01-01

    The assumption of demographic closure in the analysis of capture-recapture data under closed-population models is of fundamental importance. Yet, little progress has been made in the development of omnibus tests of the closure assumption. We present a closure test for time-specific data that, in principle, tests the null hypothesis of closed-population model M(t) against the open-population Jolly-Seber model as a specific alternative. This test is chi-square, and can be decomposed into informative components that can be interpreted to determine the nature of closure violations. The test is most sensitive to permanent emigration and least sensitive to temporary emigration, and is of intermediate sensitivity to permanent or temporary immigration. This test is a versatile tool for testing the assumption of demographic closure in the analysis of capture-recapture data.

  13. Just-in-time Design and Additive Manufacture of Patient-specific Medical Implants

    Science.gov (United States)

    Shidid, Darpan; Leary, Martin; Choong, Peter; Brandt, Milan

    Recent advances in medical imaging and manufacturing science have enabled the design and production of complex, patient-specific orthopaedic implants. Additive Manufacture (AM) generates three-dimensional structures layer by layer, and is not subject to the constraints associated with traditional manufacturing methods. AM provides significant opportunities for the design of novel geometries and complex lattice structures with enhanced functional performance. However, the design and manufacture of patient-specific AM implant structures requires unique expertise in handling various optimization platforms. Furthermore, the design process for complex structures is computationally intensive. The primary aim of this research is to enable the just-in-time customisation of AM prosthesis; whereby AM implant design and manufacture be completed within the time constraints of a single surgical procedure, while minimising prosthesis mass and optimising the lattice structure to match the stiffness of the surrounding bone tissue. In this research, a design approach using raw CT scan data is applied to the AM manufacture of femoral prosthesis. Using the proposed just-in-time concept, the mass of the prosthesis was rapidly designed and manufactured while satisfying the associated structural requirements. Compressive testing of lattice structures manufactured using proposed method shows that the load carrying capacity of the resected composite bone can be recovered by up to 85% and the compressive stiffness of the AM prosthesis is statistically indistinguishable from the stiffness of the initial bone.

  14. Travel-time source-specific station correction improves location accuracy

    Science.gov (United States)

    Giuntini, Alessandra; Materni, Valerio; Chiappini, Stefano; Carluccio, Roberto; Console, Rodolfo; Chiappini, Massimo

    2013-04-01

    Accurate earthquake locations are crucial for investigating seismogenic processes, as well as for applications like verifying compliance to the Comprehensive Test Ban Treaty (CTBT). Earthquake location accuracy is related to the degree of knowledge about the 3-D structure of seismic wave velocity in the Earth. It is well known that modeling errors of calculated travel times may have the effect of shifting the computed epicenters far from the real locations by a distance even larger than the size of the statistical error ellipses, regardless of the accuracy in picking seismic phase arrivals. The consequences of large mislocations of seismic events in the context of the CTBT verification is particularly critical in order to trigger a possible On Site Inspection (OSI). In fact, the Treaty establishes that an OSI area cannot be larger than 1000 km2, and its larger linear dimension cannot be larger than 50 km. Moreover, depth accuracy is crucial for the application of the depth event screening criterion. In the present study, we develop a method of source-specific travel times corrections based on a set of well located events recorded by dense national seismic networks in seismically active regions. The applications concern seismic sequences recorded in Japan, Iran and Italy. We show that mislocations of the order of 10-20 km affecting the epicenters, as well as larger mislocations in hypocentral depths, calculated from a global seismic network and using the standard IASPEI91 travel times can be effectively removed by applying source-specific station corrections.

  15. Sensory-specific clock components and memory mechanisms: investigation with parallel timing.

    Science.gov (United States)

    Gamache, Pierre-Luc; Grondin, Simon

    2010-05-01

    A challenge for researchers in the time-perception field is to determine whether temporal processing is governed by a central mechanism or by multiple mechanisms working in concert. Behavioral studies of parallel timing offer interesting insights into the question, although the conclusions fail to converge. Most of these studies focus on the number-of-clocks issue, but the commonality of memory mechanisms involved in time processing is often neglected. The present experiment aims to address a straightforward question: do signals from different modalities marking time intervals share the same clock and/or the same memory resources? To this end, an interval reproduction task involving the parallel timing of two sensory signals presented either in the same modality or in different modalities was conducted. The memory component was tested by manipulating the delay separating the presentation of the target intervals and the moment when the reproduction of one of these began. Results show that there is more variance when only visually marked intervals are presented, and this effect is exacerbated with longer retention delays. Finally, when there is only one interval to process, encoding the interval with signals delivered from two modalities helps to reduce variance. Taken together, these results suggest that the hypothesis stating that there are sensory-specific clock components and memory mechanisms is viable.

  16. SPECIFIC DIFFERENTIATION AND EPIDEMIOLOGICAL MARKING OF STAPHYLOCOCCUS AUREUS STRAINS DISTINGUISHED FROM THE CARRIERS OF MEDICAL PERSONNEL AND OBJECTS OF EXTERNAL ENVIRONMENT IN CURATIVE INSTITUTIONS OF THE SOUTH RAILWAY

    Directory of Open Access Journals (Sweden)

    Grechishkina Y.A.,

    2011-06-01

    Full Text Available Carried out specific differentiation of pathogenic strains of Staphylococcus aureus, which were isolated from various environmental objects surgical hospital, biomaterials from patients. The results of the research brought together strains of pathogenic staphylococci in the lytic group and 4 show the frequency of detection of each analytic group in the particular material. Received the rationale for the introduction of phage-typing method in the practical work of bacteriological laboratories, epidemiological control software in the hospital for bacteriological indicators to effectively combat nosocomial infections.

  17. Domain-Specific and Unspecific Reaction Times in Experienced Team Handball Goalkeepers and Novices.

    Science.gov (United States)

    Helm, Fabian; Reiser, Mathias; Munzert, Jörn

    2016-01-01

    In our everyday environments, we are constantly having to adapt our behavior to changing conditions. Hence, processing information is a fundamental cognitive activity, especially the linking together of perceptual and action processes. In this context, expertise research in the sport domain has concentrated on arguing that superior processing performance is driven by an advantage to be found in anticipatory processes (see Williams et al., 2011, for a review). This has resulted in less attention being paid to the benefits coming from basic internal perceptual-motor processing. In general, research on reaction time (RT) indicates that practicing a RT task leads to an increase in processing speed (Mowbray and Rhoades, 1959; Rabbitt and Banerji, 1989). Against this background, the present study examined whether the speed of internal processing is dependent on or independent from domain-specific motor expertise in unpredictable stimulus-response tasks and in a double stimulus-response paradigm. Thirty male participants (15 team handball goalkeepers and 15 novices) performed domain-unspecific simple or choice stimulus-response (CSR) tasks as well as CSR tasks that were domain-specific only for goalkeepers. As expected, results showed significantly faster RTs for goalkeepers on domain-specific tasks, whereas novices' RTs were more frequently excessively long. However, differences between groups in the double stimulus-response paradigm were not significant. It is concluded that the reported expertise advantage might be due to recalling stored perceptual-motor representations for the domain-specific tasks, implying that experience with (practice of) a motor task explicitly enhances the internal processing of other related domain-specific tasks.

  18. LITERATURE REVIEW OF PUO2 CALCINATION TIME AND TEMPERATURE DATA FOR SPECIFIC SURFACE AREA

    Energy Technology Data Exchange (ETDEWEB)

    Daniel, G.

    2012-03-06

    The literature has been reviewed in December 2011 for calcination data of plutonium oxide (PuO{sub 2}) from plutonium oxalate Pu(C{sub 2}O{sub 4}){sub 2} precipitation with respect to the PuO{sub 2} specific surface area (SSA). A summary of the literature is presented for what are believed to be the dominant factors influencing SSA, the calcination temperature and time. The PuO{sub 2} from Pu(C{sub 2}O{sub 4}){sub 2} calcination data from this review has been regressed to better understand the influence of calcination temperature and time on SSA. Based on this literature review data set, calcination temperature has a bigger impact on SSA versus time. However, there is still some variance in this data set that may be reflecting differences in the plutonium oxalate preparation or different calcination techniques. It is evident from this review that additional calcination temperature and time data for PuO{sub 2} from Pu(C{sub 2}O{sub 4}){sub 2} needs to be collected and evaluated to better define the relationship. The existing data set has a lot of calcination times that are about 2 hours and therefore may be underestimating the impact of heating time on SSA. SRNL recommends that more calcination temperature and time data for PuO{sub 2} from Pu(C{sub 2}O{sub 4}){sub 2} be collected and this literature review data set be augmented to better refine the relationship between PuO{sub 2} SSA and its calcination parameters.

  19. Time-specific ecological niche modeling predicts spatial dynamics of vector insects and human dengue cases.

    Science.gov (United States)

    Peterson, A Townsend; Martínez-Campos, Carmen; Nakazawa, Yoshinori; Martínez-Meyer, Enrique

    2005-09-01

    Numerous human diseases-malaria, dengue, yellow fever and leishmaniasis, to name a few-are transmitted by insect vectors with brief life cycles and biting activity that varies in both space and time. Although the general geographic distributions of these epidemiologically important species are known, the spatiotemporal variation in their emergence and activity remains poorly understood. We used ecological niche modeling via a genetic algorithm to produce time-specific predictive models of monthly distributions of Aedes aegypti in Mexico in 1995. Significant predictions of monthly mosquito activity and distributions indicate that predicting spatiotemporal dynamics of disease vector species is feasible; significant coincidence with human cases of dengue indicate that these dynamics probably translate directly into transmission of dengue virus to humans. This approach provides new potential for optimizing use of resources for disease prevention and remediation via automated forecasting of disease transmission risk.

  20. Iranian Students’ Specific Life Style and Leisure Time; a Case Study of University of Tehran

    Directory of Open Access Journals (Sweden)

    Ali Akbar Ramazaniandarzi

    2018-01-01

    Full Text Available Leisure time as a modern social is being focused these days, albeit any sort of interest isn't specifically arranged under it. Inside this exploration the framing encounters of necessities and styles of college students were examined. In this examination it has been attempted by using Bourdieu hypothesis the exploration questions are proposed. The members of the examination are for the most part female and male understudies University of Tehran. The specimen was picked by the use of Cochran with the standard deviation of 0.4.5% 470 students. The outcomes demonstrated that members can isolate in two sections dynamic and idle style which the vast majority of interviewees are willing toward a dormant style of relaxation time. While the significant piece of understudies' chance is spent on the utilization of innovative devices conveniently. For sure, watching satellite motion pictures and arrangement, investing energy in broad daylight talk rooms, PC amusements, are only a misuse of understudies' opportunity.

  1. System-level Specifications of the Timing and Fast Control system for the LHCb Upgrade

    CERN Document Server

    Alessio, Federico

    2014-01-01

    The LHCb experiment has proposed an upgrade towards a full 40 MHz readout system in order to run between five and ten times the initial design luminosity. The various sub-systems in the readout architecture will need to be upgraded in order to cope with higher sub-detector occupancies, higher rate and higher network load. In this paper, we describe the specifications of the new Timing and Fast Control (S- TFC) system. We define the requirements for the new S-TFC, and specify its architecture and the individual components. The system is based on a single new Readout Supervisor (S-ODIN) instantiating several S-TFC masters to allow partitioning. The communication with the readout electronics is ensured by a shared high-speed optical link network for both the distribution of timing and synchronous control information, as well as trigger/throttle communication. An interface board (SOL40) with fan-out capabilities for timing and synchronous information and fan-in capabilities for throttle and rate regulation of the...

  2. Stimulating at the right time: phase-specific deep brain stimulation.

    Science.gov (United States)

    Cagnan, Hayriye; Pedrosa, David; Little, Simon; Pogosyan, Alek; Cheeran, Binith; Aziz, Tipu; Green, Alexander; Fitzgerald, James; Foltynie, Thomas; Limousin, Patricia; Zrinzo, Ludvic; Hariz, Marwan; Friston, Karl J; Denison, Timothy; Brown, Peter

    2017-01-01

    SEE MOLL AND ENGEL DOI101093/AWW308 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Brain regions dynamically engage and disengage with one another to execute everyday actions from movement to decision making. Pathologies such as Parkinson's disease and tremor emerge when brain regions controlling movement cannot readily decouple, compromising motor function. Here, we propose a novel stimulation strategy that selectively regulates neural synchrony through phase-specific stimulation. We demonstrate for the first time the therapeutic potential of such a stimulation strategy for the treatment of patients with pathological tremor. Symptom suppression is achieved by delivering stimulation to the ventrolateral thalamus, timed according to the patient's tremor rhythm. Sustained locking of deep brain stimulation to a particular phase of tremor afforded clinically significant tremor relief (up to 87% tremor suppression) in selected patients with essential tremor despite delivering less than half the energy of conventional high frequency stimulation. Phase-specific stimulation efficacy depended on the resonant characteristics of the underlying tremor network. Selective regulation of neural synchrony through phase-locked stimulation has the potential to both increase the efficiency of therapy and to minimize stimulation-induced side effects. © The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain.

  3. Modeling road traffic fatalities in India: Smeed's law, time invariance and regional specificity

    Directory of Open Access Journals (Sweden)

    Raj V. Ponnaluri

    2012-07-01

    Full Text Available Mathematical formulations linking road traffic fatalities to vehicle ownership, regional population, and economic growth continue to be developed against the backdrop of Smeed and Andreassen models. Though a few attempts were made, Smeed's law has not been fully tested in India. Using the 1991–2009 panel data from all states, this work (a developed the generalized Smeed and Andreassen models; (b evaluated if traffic fatalities were impacted by structural changes; and (c examined if – in relation to the generalized model – the individual (time and regional models are more relevant for application. Seven models (Smeed: original, generalized, time-variant, state-variant; and Andreassen: generalized, time-variant, state-variant were developed and tested for fit with the actual data. Results showed that the per vehicle fatality rate closely resembled Smeed's formulation. Chow-test yielded a significant F-stat, suggesting that the models for four pre-defined time-blocks are structurally different from the 19-year generalized model. The counterclockwise rotation of the log-linear form also suggested lower fatality rates. While the new government policies, reduced vehicle operating speeds, better healthcare, and improved vehicle technology could be the factors, further research is required to understand the reasons for fatality rate reductions. The intercept and gradients of the time-series models showed high stability and varied only slightly in comparison to the 19-year generalized models, thus suggesting that the latter are pragmatic for application. Regional formulations, however, indicate that they may be more relevant for studying trends and tendencies. This research illustrates the robustness of Smeed's law, and provides evidence for time-invariance but state-specificity.

  4. Patient specific dynamic geometric models from sequential volumetric time series image data.

    Science.gov (United States)

    Cameron, B M; Robb, R A

    2004-01-01

    Generating patient specific dynamic models is complicated by the complexity of the motion intrinsic and extrinsic to the anatomic structures being modeled. Using a physics-based sequentially deforming algorithm, an anatomically accurate dynamic four-dimensional model can be created from a sequence of 3-D volumetric time series data sets. While such algorithms may accurately track the cyclic non-linear motion of the heart, they generally fail to accurately track extrinsic structural and non-cyclic motion. To accurately model these motions, we have modified a physics-based deformation algorithm to use a meta-surface defining the temporal and spatial maxima of the anatomic structure as the base reference surface. A mass-spring physics-based deformable model, which can expand or shrink with the local intrinsic motion, is applied to the metasurface, deforming this base reference surface to the volumetric data at each time point. As the meta-surface encompasses the temporal maxima of the structure, any extrinsic motion is inherently encoded into the base reference surface and allows the computation of the time point surfaces to be performed in parallel. The resultant 4-D model can be interactively transformed and viewed from different angles, showing the spatial and temporal motion of the anatomic structure. Using texture maps and per-vertex coloring, additional data such as physiological and/or biomechanical variables (e.g., mapping electrical activation sequences onto contracting myocardial surfaces) can be associated with the dynamic model, producing a 5-D model. For acquisition systems that may capture only limited time series data (e.g., only images at end-diastole/end-systole or inhalation/exhalation), this algorithm can provide useful interpolated surfaces between the time points. Such models help minimize the number of time points required to usefully depict the motion of anatomic structures for quantitative assessment of regional dynamics.

  5. PINK1 is required for timely cell-type specific mitochondrial clearance during Drosophila midgut metamorphosis.

    Science.gov (United States)

    Liu, Yan; Lin, Jingjing; Zhang, Minjie; Chen, Kai; Yang, Shengxi; Wang, Qun; Yang, Hongqin; Xie, Shusen; Zhou, Yongjian; Zhang, Xi; Chen, Fei; Yang, Yufeng

    2016-11-15

    Mitophagy is the selective degradation of mitochondria by autophagy, which is an important mitochondrial quality and quantity control process. During Drosophila metamorphosis, the degradation of midgut involves a large change in length and organization, which is mediated by autophagy. Here we noticed a cell-type specific mitochondrial clearance process that occurs in enterocytes (ECs), while most mitochondria remain in intestinal stem cells (ISCs) during metamorphosis. Although PINK1/PARKIN represent the canonical pathway for the elimination of impaired mitochondria in varied pathological conditions, their roles in developmental processes or normal physiological conditions have been less studied. To examine the potential contribution of PINK1 in developmental processes, we monitored the dynamic expression pattern of PINK1 in the midgut development by taking advantage of a newly CRISPR/Cas9 generated knock-in fly strain expressing PINK1-mCherry fusion protein that presumably recapitulates the endogenous expression pattern of PINK1. We disclosed a spatiotemporal correlation between the expression pattern of PINK1 and the mitochondrial clearance or persistence in ECs or ISCs respectively. By mosaic genetic analysis, we then demonstrated that PINK1 and PARKIN function epistatically to mediate the specific timely removal of mitochondria, and are involved in global autophagy in ECs during Drosophila midgut metamorphosis, with kinase-dead PINK1 exerting dominant negative effects. Taken together, our studies concluded that the PINK1/PARKIN is crucial for timely cell-type specific mitophagy under physiological conditions and demonstrated again that Drosophila midgut metamorphosis might serve as an elegant in vivo model to study autophagy. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Context-specific activation of hippocampus and SN/VTA by reward is related to enhanced long-term memory for embedded objects.

    Science.gov (United States)

    Loh, Eleanor; Kumaran, Dharshan; Koster, Raphael; Berron, David; Dolan, Ray; Duzel, Emrah

    2016-10-01

    Animal studies indicate that hippocampal representations of environmental context modulate reward-related processing in the substantia nigra and ventral tegmental area (SN/VTA), a major origin of dopamine in the brain. Using functional magnetic resonance imaging (fMRI) in humans, we investigated the neural specificity of context-reward associations under conditions where the presence of perceptually similar neutral contexts imposed high demands on a putative hippocampal function, pattern separation. The design also allowed us to investigate how contextual reward enhances long-term memory for embedded neutral objects. SN/VTA activity underpinned specific context-reward associations in the face of perceptual similarity. A reward-related enhancement of long-term memory was restricted to the condition where the rewarding and the neutral contexts were perceptually similar, and in turn was linked to co-activation of the hippocampus (subfield DG/CA3) and SN/VTA. Thus, an ability of contextual reward to enhance memory for focal objects is closely linked to context-related engagement of hippocampal-SN/VTA circuitry. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  7. A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension.

    Science.gov (United States)

    Pugliese, Steven C; Kumar, Sushil; Janssen, William J; Graham, Brian B; Frid, Maria G; Riddle, Suzette R; El Kasmi, Karim C; Stenmark, Kurt R

    2017-06-15

    Studies in various animal models suggest an important role for pulmonary macrophages in the pathogenesis of pulmonary hypertension (PH). Yet, the molecular mechanisms characterizing the functional macrophage phenotype relative to time and pulmonary localization and compartmentalization remain largely unknown. In this study, we used a hypoxic murine model of PH in combination with FACS to quantify and isolate lung macrophages from two compartments over time and characterize their programing via RNA sequencing approaches. In response to hypoxia, we found an early increase in macrophage number that was restricted to the interstitial/perivascular compartment, without recruitment of macrophages to the alveolar compartment or changes in the number of resident alveolar macrophages. Principal component analysis demonstrated significant differences in overall gene expression between alveolar and interstitial macrophages (IMs) at baseline and after 4 and 14 d hypoxic exposure. Alveolar macrophages at both day 4 and 14 and IMs at day 4 shared a conserved hypoxia program characterized by mitochondrial dysfunction, proinflammatory gene activation, and mTORC1 signaling, whereas IMs at day 14 demonstrated a unique anti-inflammatory/proreparative programming state. We conclude that the pathogenesis of vascular remodeling in hypoxic PH involves an early compartment-independent activation of lung macrophages toward a conserved hypoxia program, with the development of compartment-specific programs later in the course of the disease. Thus, harnessing time- and compartment-specific differences in lung macrophage polarization needs to be considered in the therapeutic targeting of macrophages in hypoxic PH and potentially other inflammatory lung diseases. Copyright © 2017 by The American Association of Immunologists, Inc.

  8. Low cost, robust and real time system for detecting and tracking moving objects to automate cargo handling in port terminals

    NARCIS (Netherlands)

    Vaquero, V.; Repiso, E.; Sanfeliu, A.; Vissers, J.; Kwakkernaat, M.

    2016-01-01

    The presented paper addresses the problem of detecting and tracking moving objects for autonomous cargo handling in port terminals using a perception system which input data is a single layer laser scanner. A computationally low cost and robust Detection and Tracking Moving Objects (DATMO) algorithm

  9. Individual and hospital-specific factors influencing medical graduates' time to medical specialization.

    Science.gov (United States)

    Johannessen, Karl-Arne; Hagen, Terje P

    2013-11-01

    Previous studies of gender differences in relation to medical specialization have focused more on social variables than hospital-specific factors. In a multivariate analysis with extended Cox regression, we used register data for socio-demographic variables (gender, family and having a child born during the study period) together with hospital-specific variables (the amount of supervision available, efficiency pressure and the type of teaching hospital) to study the concurrent effect of these variables on specialty qualification among all 2474 Norwegian residents who began specialization in 1999-2001. We followed the residents until 2010. A lower proportion of women qualified for a specialty in the study period (67.9% compared with 78.7% of men, p specialization qualification (p specialization: working at university hospitals (regional) or central hospitals was associated with a reduction in the time taken to complete the specialization, whereas an increased patient load and less supervision had the opposite effect. Multivariate analysis showed that the smaller proportion of women who qualified for a specialty was explained principally by childbirth and by the number of children aged under 18 years. Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. Audiovisual semantic interactions between linguistic and nonlinguistic stimuli: The time-courses and categorical specificity.

    Science.gov (United States)

    Chen, Yi-Chuan; Spence, Charles

    2018-04-30

    We examined the time-courses and categorical specificity of the crossmodal semantic congruency effects elicited by naturalistic sounds and spoken words on the processing of visual pictures (Experiment 1) and printed words (Experiment 2). Auditory cues were presented at 7 different stimulus onset asynchronies (SOAs) with respect to the visual targets, and participants made speeded categorization judgments (living vs. nonliving). Three common effects were observed across 2 experiments: Both naturalistic sounds and spoken words induced a slowly emerging congruency effect when leading by 250 ms or more in the congruent compared with the incongruent condition, and a rapidly emerging inhibitory effect when leading by 250 ms or less in the incongruent condition as opposed to the noise condition. Only spoken words that did not match the visual targets elicited an additional inhibitory effect when leading by 100 ms or when presented simultaneously. Compared with nonlinguistic stimuli, the crossmodal congruency effects associated with linguistic stimuli occurred over a wider range of SOAs and occurred at a more specific level of the category hierarchy (i.e., the basic level) than was required by the task. A comprehensive framework is proposed to provide a dynamic view regarding how meaning is extracted during the processing of visual or auditory linguistic and nonlinguistic stimuli, therefore contributing to our understanding of multisensory semantic processing in humans. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  11. Timing of Maternal Depression and Sex-Specific Child Growth, the Upstate KIDS Study.

    Science.gov (United States)

    Park, Hyojun; Sundaram, Rajeshwari; Gilman, Stephen E; Bell, Griffith; Louis, Germaine M Buck; Yeung, Edwina H

    2018-01-01

    Equivocal findings have been reported on the association between maternal depression and children's growth, possibly because of the limited attention to its disproportionate impact by child sex. The relationship between the timing of maternal depression and children's growth was assessed in a population-based prospective birth cohort, with particular attention to sex differences. The Upstate KIDS Study comprised 4,394 children followed through 3 years of age from 2008 to 2010. Maternal depression was measured antenatally by linkage with hospital discharge records before delivery and postnatally by depressive symptoms reported from questionnaires. Children's growth was measured by sex- and age-specific weight, height, weight for height, and BMI. Adjusted linear mixed effects models were used to estimate growth outcomes for the full sample and separately by plurality and sex. Antenatal depression was associated with lower weight for age (-0.24 z score units; 95% confidence interval [CI]: -0.43, -0.05) and height for age (-0.26 z score units; 95% CI: -0.51, -0.02) among singleton boys. Postnatal depressive symptoms were associated with higher weight for height (0.21 z score units; 95% CI: 0.01, 0.42) among singleton girls. The findings of this study suggest that antenatal depression was associated with lower weight and smaller height only for boys, whereas postnatal depressive symptoms were associated with higher weight for height only for girls. The timing of depression and the mechanisms of sex-specific responses require further examination. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.

  12. Risk-based technical specifications: Development and application of an approach to the generation of a plant specific real-time risk model

    International Nuclear Information System (INIS)

    Puglia, B.; Gallagher, D.; Amico, P.; Atefi, B.

    1992-10-01

    This report describes a process developed to convert an existing PRA into a model amenable to real time, risk-based technical specification calculations. In earlier studies (culminating in NUREG/CR-5742), several risk-based approaches to technical specification were evaluated. A real-time approach using a plant specific PRA capable of modeling plant configurations as they change was identified as the most comprehensive approach to control plant risk. A master fault tree logic model representative of-all of the core damage sequences was developed. Portions of the system fault trees were modularized and supercomponents comprised of component failures with similar effects were developed to reduce the size of the model and, quantification times. Modifications to the master fault tree logic were made to properly model the effect of maintenance and recovery actions. Fault trees representing several actuation systems not modeled in detail in the existing PRA were added to the master fault tree logic. This process was applied to the Surry NUREG-1150 Level 1 PRA. The master logic mode was confirmed. The model was then used to evaluate frequency associated with several plant configurations using the IRRAS code. For all cases analyzed computational time was less than three minutes. This document Volume 2, contains appendices A, B, and C. These provide, respectively: Surry Technical Specifications Model Database, Surry Technical Specifications Model, and a list of supercomponents used in the Surry Technical Specifications Model

  13. QUALITY OF NURSING DOCUMENTATION AND NURSE’S OBJECTIVE WORKLOAD BASED ON TIME AND MOTION STUDY (TMS

    Directory of Open Access Journals (Sweden)

    Mira Amelynda Prakosa

    2017-02-01

    Full Text Available Introduction. The quality of documentation can decrease because of bad admission filling of documentation. Workload is one of the factor that can influence admission filling of documentation. This study was aimed to analyze the correlation between nurse’s objective workload and the quality of nursing documentation in RSU Haji. Method. The design of this study was descriptive correlation with cross-sectional approach. The population on this study was the nurse that works in Marwah 3 and 4 inpatient care in RSU Haji Surabaya. The number of the sample was 14 respondents were selected by simple random sampling. The independent variable was nurse’s objective workload and the dependent variable was quality of nursing documentation. The data were analyzed by using regression logistic. Result. Nurse’s objective workload in RSU Haji was 72%. There was no correlational between nurse’s objective workload with the completeness of nursing documentation (P= 0,999, also nurse’s objective workload with accurate of nursing documentation (P= 0,999. Discussion. This study concluded that nurse’s objective workload was low and quality of nursing documentation was accurate enough and complete enough. Next researcher should provide precise operational so the factors that affected the quality of documentation can be reached and the workload of the nurses in RSU Haji become ideal. Keyword:  nurses, quality of nursing documentation, objective workload

  14. A Standard for Sharing and Accessing Time Series Data: The Heliophysics Application Programmers Interface (HAPI) Specification

    Science.gov (United States)

    Vandegriff, J. D.; King, T. A.; Weigel, R. S.; Faden, J.; Roberts, D. A.; Harris, B. T.; Lal, N.; Boardsen, S. A.; Candey, R. M.; Lindholm, D. M.

    2017-12-01

    We present the Heliophysics Application Programmers Interface (HAPI), a new interface specification that both large and small data centers can use to expose time series data holdings in a standard way. HAPI was inspired by the similarity of existing services at many Heliophysics data centers, and these data centers have collaborated to define a single interface that captures best practices and represents what everyone considers the essential, lowest common denominator for basic data access. This low level access can serve as infrastructure to support greatly enhanced interoperability among analysis tools, with the goal being simplified analysis and comparison of data from any instrument, model, mission or data center. The three main services a HAPI server must perform are 1. list a catalog of datasets (one unique ID per dataset), 2. describe the content of one dataset (JSON metadata), and 3. retrieve numerical content for one dataset (stream the actual data). HAPI defines both the format of the query to the server, and the response from the server. The metadata is lightweight, focusing on use rather than discovery, and the data format is a streaming one, with Comma Separated Values (CSV) being required and binary or JSON streaming being optional. The HAPI specification is available at GitHub, where projects are also underway to develop reference implementation servers that data providers can adapt and use at their own sites. Also in the works are data analysis clients in multiple languages (IDL, Python, Matlab, and Java). Institutions which have agreed to adopt HAPI include Goddard (CDAWeb for data and CCMC for models), LASP at the University of Colorado Boulder, the Particles and Plasma Interactions node of the Planetary Data System (PPI/PDS) at UCLA, the Plasma Wave Group at the University of Iowa, the Space Sector at the Johns Hopkins Applied Physics Lab (APL), and the tsds.org site maintained at George Mason University. Over the next year, the adoption of a

  15. Effects of age on the soccer-specific cognitive-motor performance of elite young soccer players: Comparison between objective measurements and coaches’ evaluation

    Science.gov (United States)

    Chauvin, Alan; Chassot, Steve; Chenevière, Xavier; Taube, Wolfgang

    2017-01-01

    The cognitive-motor performance (CMP), defined here as the capacity to rapidly use sensory information and transfer it into efficient motor output, represents a major contributor to performance in almost all sports, including soccer. Here, we used a high-technology system (COGNIFOOT) which combines a visual environment simulator fully synchronized with a motion capture system. This system allowed us to measure objective real-time CMP parameters (passing accuracy/speed and response times) in a large turf-artificial grass playfield. Forty-six (46) young elite soccer players (including 2 female players) aged between 11 and 16 years who belonged to the same youth soccer academy were tested. Each player had to pass the ball as fast and as accurately as possible towards visual targets projected onto a large screen located 5.32 meters in front of him (a short pass situation). We observed a linear age-related increase in the CMP: the passing accuracy, speed and reactiveness of players improved by 4 centimeters, 2.3 km/h and 30 milliseconds per year of age, respectively. These data were converted into 5 point-scales and compared to the judgement of expert coaches, who also used a 5 point-scale to evaluate the same CMP parameters but based on their experience with the players during games and training. The objectively-measured age-related CMP changes were also observed in expert coaches’ judgments although these were more variable across coaches and age categories. This demonstrates that high-technology systems like COGNIFOOT can be used in complement to traditional approaches of talent identification and to objectively monitor the progress of soccer players throughout a cognitive-motor training cycle. PMID:28953958

  16. Effects of age on the soccer-specific cognitive-motor performance of elite young soccer players: Comparison between objective measurements and coaches' evaluation.

    Science.gov (United States)

    Hicheur, Halim; Chauvin, Alan; Chassot, Steve; Chenevière, Xavier; Taube, Wolfgang

    2017-01-01

    The cognitive-motor performance (CMP), defined here as the capacity to rapidly use sensory information and transfer it into efficient motor output, represents a major contributor to performance in almost all sports, including soccer. Here, we used a high-technology system (COGNIFOOT) which combines a visual environment simulator fully synchronized with a motion capture system. This system allowed us to measure objective real-time CMP parameters (passing accuracy/speed and response times) in a large turf-artificial grass playfield. Forty-six (46) young elite soccer players (including 2 female players) aged between 11 and 16 years who belonged to the same youth soccer academy were tested. Each player had to pass the ball as fast and as accurately as possible towards visual targets projected onto a large screen located 5.32 meters in front of him (a short pass situation). We observed a linear age-related increase in the CMP: the passing accuracy, speed and reactiveness of players improved by 4 centimeters, 2.3 km/h and 30 milliseconds per year of age, respectively. These data were converted into 5 point-scales and compared to the judgement of expert coaches, who also used a 5 point-scale to evaluate the same CMP parameters but based on their experience with the players during games and training. The objectively-measured age-related CMP changes were also observed in expert coaches' judgments although these were more variable across coaches and age categories. This demonstrates that high-technology systems like COGNIFOOT can be used in complement to traditional approaches of talent identification and to objectively monitor the progress of soccer players throughout a cognitive-motor training cycle.

  17. Effects of age on the soccer-specific cognitive-motor performance of elite young soccer players: Comparison between objective measurements and coaches' evaluation.

    Directory of Open Access Journals (Sweden)

    Halim Hicheur

    Full Text Available The cognitive-motor performance (CMP, defined here as the capacity to rapidly use sensory information and transfer it into efficient motor output, represents a major contributor to performance in almost all sports, including soccer. Here, we used a high-technology system (COGNIFOOT which combines a visual environment simulator fully synchronized with a motion capture system. This system allowed us to measure objective real-time CMP parameters (passing accuracy/speed and response times in a large turf-artificial grass playfield. Forty-six (46 young elite soccer players (including 2 female players aged between 11 and 16 years who belonged to the same youth soccer academy were tested. Each player had to pass the ball as fast and as accurately as possible towards visual targets projected onto a large screen located 5.32 meters in front of him (a short pass situation. We observed a linear age-related increase in the CMP: the passing accuracy, speed and reactiveness of players improved by 4 centimeters, 2.3 km/h and 30 milliseconds per year of age, respectively. These data were converted into 5 point-scales and compared to the judgement of expert coaches, who also used a 5 point-scale to evaluate the same CMP parameters but based on their experience with the players during games and training. The objectively-measured age-related CMP changes were also observed in expert coaches' judgments although these were more variable across coaches and age categories. This demonstrates that high-technology systems like COGNIFOOT can be used in complement to traditional approaches of talent identification and to objectively monitor the progress of soccer players throughout a cognitive-motor training cycle.

  18. Subgroup analyses in confirmatory clinical trials: time to be specific about their purposes

    Directory of Open Access Journals (Sweden)

    Julien Tanniou

    2016-02-01

    Full Text Available Abstract Background It is well recognized that treatment effects may not be homogeneous across the study population. Subgroup analyses constitute a fundamental step in the assessment of evidence from confirmatory (Phase III clinical trials, where conclusions for the overall study population might not hold. Subgroup analyses can have different and distinct purposes, requiring specific design and analysis solutions. It is relevant to evaluate methodological developments in subgroup analyses against these purposes to guide health care professionals and regulators as well as to identify gaps in current methodology. Methods We defined four purposes for subgroup analyses: (1 Investigate the consistency of treatment effects across subgroups of clinical importance, (2 Explore the treatment effect across different subgroups within an overall non-significant trial, (3 Evaluate safety profiles limited to one or a few subgroup(s, (4 Establish efficacy in the targeted subgroup when included in a confirmatory testing strategy of a single trial. We reviewed the methodology in line with this “purpose-based” framework. The review covered papers published between January 2005 and April 2015 and aimed to classify them in none, one or more of the aforementioned purposes. Results In total 1857 potentially eligible papers were identified. Forty-eight papers were selected and 20 additional relevant papers were identified from their references, leading to 68 papers in total. Nineteen were dedicated to purpose 1, 16 to purpose 4, one to purpose 2 and none to purpose 3. Seven papers were dedicated to more than one purpose, the 25 remaining could not be classified unambiguously. Purposes of the methods were often not specifically indicated, methods for subgroup analysis for safety purposes were almost absent and a multitude of diverse methods were developed for purpose (1. Conclusions It is important that researchers developing methodology for subgroup analysis

  19. RAMS+C informed decision-making with application to multi-objective optimization of technical specifications and maintenance using genetic algorithms

    International Nuclear Information System (INIS)

    Martorell, S.; Villanueva, J.F.; Carlos, S.; Nebot, Y.; Sanchez, A.; Pitarch, J.L.; Serradell, V.

    2005-01-01

    The role of technical specifications and maintenance (TSM) activities at nuclear power plants (NPP) aims to increase reliability, availability and maintainability (RAM) of Safety-Related Equipment, which, in turn, must yield to an improved level of plant safety. However, more resources (e.g. costs, task force, etc.) have to be assigned in above areas to achieve better scores in reliability, availability, maintainability and safety (RAMS). Current situation at NPP shows different programs implemented at the plant that aim to the improvement of particular TSM-related parameters where the decision-making process is based on the assessment of the impact of the change proposed on a subgroup of RAMS+C attributes. This paper briefly reviews the role of TSM and two main groups of improvement programs at NPP, which suggest the convenience of considering the approach proposed in this paper for the Integrated Multi-Criteria Decision-Making on changes to TSM-related parameters based on RAMS+C criteria as a whole, as it can be seem as a decision-making process more consistent with the role and synergic effects of TSM and the objectives and goals of current improvement programs at NPP. The case of application to the Emergency Diesel Generator system demonstrates the viability and significance of the proposed approach for the Multi-objective Optimization of TSM-related parameters using a Genetic Algorithm

  20. Highly sensitive real-time PCR for specific detection and quantification of Coxiella burnetii

    Directory of Open Access Journals (Sweden)

    Linke Sonja

    2006-01-01

    Full Text Available Abstract Background Coxiella burnetii, the bacterium causing Q fever, is an obligate intracellular biosafety level 3 agent. Detection and quantification of these bacteria with conventional methods is time consuming and dangerous. During the last years, several PCR based diagnostic assays were developed to detect C. burnetii DNA in cell cultures and clinical samples. We developed and evaluated TaqMan-based real-time PCR assays that targeted the singular icd (isocitrate dehydrogenase gene and the transposase of the IS1111a element present in multiple copies in the C. burnetii genome. Results To evaluate the precision of the icd and IS1111 real-time PCR assays, we performed different PCR runs with independent DNA dilutions of the C. burnetii Nine Mile RSA493 strain. The results showed very low variability, indicating efficient reproducibility of both assays. Using probit analysis, we determined that the minimal number of genome equivalents per reaction that could be detected with a 95% probability was 10 for the icd marker and 6.5 for the IS marker. Plasmid standards with cloned icd and IS1111 fragments were used to establish standard curves which were linear over a range from 10 to 107 starting plasmid copy numbers. We were able to quantify cell numbers of a diluted, heat-inactivated Coxiella isolate with a detection limit of 17 C. burnetii particles per reaction. Real-time PCR targeting both markers was performed with DNA of 75 different C. burnetii isolates originating from all over the world. Using this approach, the number of IS1111 elements in the genome of the Nine Mile strain was determined to be 23, close to 20, the number revealed by genome sequencing. In other isolates, the number of IS1111 elements varied widely (between seven and 110 and seemed to be very high in some isolates. Conclusion We validated TaqMan-based real-time PCR assays targeting the icd and IS1111 markers of C. burnetii. The assays were shown to be specific, highly

  1. First off-time treatment prostate-specific antigen kinetics predicts survival in intermittent androgen deprivation for prostate cancer.

    Science.gov (United States)

    Sanchez-Salas, Rafael; Olivier, Fabien; Prapotnich, Dominique; Dancausa, José; Fhima, Mehdi; David, Stéphane; Secin, Fernando P; Ingels, Alexandre; Barret, Eric; Galiano, Marc; Rozet, François; Cathelineau, Xavier

    2016-01-01

    Prostate-specific antigen (PSA) doubling time is relying on an exponential kinetic pattern. This pattern has never been validated in the setting of intermittent androgen deprivation (IAD). Objective is to analyze the prognostic significance for PCa of recurrent patterns in PSA kinetics in patients undergoing IAD. A retrospective study was conducted on 377 patients treated with IAD. On-treatment period (ONTP) consisted of gonadotropin-releasing hormone agonist injections combined with oral androgen receptor antagonist. Off-treatment period (OFTP) began when PSA was lower than 4 ng/ml. ONTP resumed when PSA was higher than 20 ng/ml. PSA values of each OFTP were fitted with three basic patterns: exponential (PSA(t) = λ.e(αt)), linear (PSA(t) = a.t), and power law (PSA(t) = a.t(c)). Univariate and multivariate Cox regression model analyzed predictive factors for oncologic outcomes. Only 45% of the analyzed OFTPs were exponential. Linear and power law PSA kinetics represented 7.5% and 7.7%, respectively. Remaining fraction of analyzed OFTPs (40%) exhibited complex kinetics. Exponential PSA kinetics during the first OFTP was significantly associated with worse oncologic outcome. The estimated 10-year cancer-specific survival (CSS) was 46% for exponential versus 80% for nonexponential PSA kinetics patterns. The corresponding 10-year probability of castration-resistant prostate cancer (CRPC) was 69% and 31% for the two patterns, respectively. Limitations include retrospective design and mixed indications for IAD. PSA kinetic fitted with exponential pattern in approximately half of the OFTPs. First OFTP exponential PSA kinetic was associated with a shorter time to CRPC and worse CSS. © 2015 Wiley Periodicals, Inc.

  2. Formal Specification and Verification of Real-Time Multi-Agent Systems using Timed-Arc Petri Nets

    OpenAIRE

    QASIM, A.; KAZMI, S. A. R.; FAKHIR, I.

    2015-01-01

    In this study we have formally specified and verified the actions of communicating real-time software agents (RTAgents). Software agents are expected to work autonomously and deal with unfamiliar situations astutely. Achieving cent percent test cases coverage for these agents has always been a problem due to limited resources. Also a high degree of dependability and predictability is expected from real-time software agents. In this research we have used Timed-Arc Petri Net...

  3. A real time dose monitoring and dose reconstruction tool for patient specific VMAT QA and delivery

    International Nuclear Information System (INIS)

    Tyagi, Neelam; Yang Kai; Gersten, David; Yan Di

    2012-01-01

    Purpose: To develop a real time dose monitoring and dose reconstruction tool to identify and quantify sources of errors during patient specific volumetric modulated arc therapy (VMAT) delivery and quality assurance. Methods: The authors develop a VMAT delivery monitor tool called linac data monitor that connects to the linac in clinical mode and records, displays, and compares real time machine parameters with the planned parameters. A new measure, called integral error, keeps a running total of leaf overshoot and undershoot errors in each leaf pair, multiplied by leaf width, and the amount of time during which the error exists in monitor unit delivery. Another tool reconstructs Pinnacle 3 ™ format delivered plan based on the saved machine logfile and recalculates actual delivered dose in patient anatomy. Delivery characteristics of various standard fractionation and stereotactic body radiation therapy (SBRT) VMAT plans delivered on Elekta Axesse and Synergy linacs were quantified. Results: The MLC and gantry errors for all the treatment sites were 0.00 ± 0.59 mm and 0.05 ± 0.31°, indicating a good MLC gain calibration. Standard fractionation plans had a larger gantry error than SBRT plans due to frequent dose rate changes. On average, the MLC errors were negligible but larger errors of up to 6 mm and 2.5° were seen when dose rate varied frequently. Large gantry errors occurred during the acceleration and deceleration process, and correlated well with MLC errors (r= 0.858, p= 0.0004). PTV mean, minimum, and maximum dose discrepancies were 0.87 ± 0.21%, 0.99 ± 0.59%, and 1.18 ± 0.52%, respectively. The organs at risk (OAR) doses were within 2.5%, except some OARs that showed up to 5.6% discrepancy in maximum dose. Real time displayed normalized total positive integral error (normalized to the total monitor units) correlated linearly with MLC (r= 0.9279, p < 0.001) and gantry errors (r= 0.742, p= 0.005). There is a strong correlation between total integral

  4. Real-time PCR for type-specific identification of herpes simplex in clinical samples: evaluation of type-specific results in the context of CNS diseases.

    Science.gov (United States)

    Meylan, Sylvain; Robert, Daniel; Estrade, Christine; Grimbuehler, Valérie; Péter, Olivier; Meylan, Pascal R; Sahli, Roland

    2008-02-01

    HSV-1 and HSV-2 cause CNS infections of dissimilar clinico-pathological characteristics with prognostic and therapeutic implications. To validate a type-specific real-time PCR that uses MGB/LNA Taqman probes and to review the virologico-clinical data of 25 eligible patients with non-neonatal CNS infections. This real-time PCR was evaluated against conventional PCR (26 CSF and 20 quality controls), and LightCycler assay (51 mucocutaneous, 8 CSF and 32 quality controls) and culture/immunofluorescence (75 mucocutaneous) to assess typing with independent methods. Taqman real-time PCR detected 240 HSV genomes per ml CSF, a level appropriate for the management of patients, and provided unambiguous typing for the 104 positive (62 HSV-1 and 42 HSV-2) out the 160 independent clinical samples tested. HSV type diagnosed by Taqman real-time PCR predicted final diagnosis (meningitis versus encephalitis/meningoencephalitis, p<0.001) in 24/25 patients at time of presentation, in contrast to clinical evaluation. Our real-time PCR, as a sensitive and specific means for type-specific HSV diagnosis, provided rapid prognostic information for patient management.

  5. It is time to regulate carcinogenic tobacco-specific nitrosamines in cigarette tobacco

    Science.gov (United States)

    Hecht, Stephen S.

    2014-01-01

    The Family Smoking Prevention and Tobacco Control Act gives the Food and Drug Administration power to regulate tobacco products. This commentary calls for immediate regulation of the carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N’-nitrosonornicotine (NNN) in cigarette tobacco as a logical path to cancer prevention. NNK and NNN, powerful carcinogens in laboratory animals, have been evaluated as “carcinogenic to humans” by the International Agency for Research on Cancer. NNK and NNN are present in the tobacco of virtually all marketed cigarettes; levels in cigarette smoke are directly proportional to the amounts in tobacco. The NNK metabolite NNAL, itself a strong carcinogen, is present in the urine of smokers and non-smokers exposed to secondhand smoke. Some of the highest levels of NNK and NNN are found in U.S. products. It is well established that factors such as choice of tobacco blend, agricultural conditions, and processing methods influence levels of NNK and NNN in cigarette tobacco and cigarette smoke. Therefore, it is time to control these factors and produce cigarettes with 100 ppb or less each of NNK and NNN in tobacco, which would result in an approximate 15-20 fold reduction of these carcinogens in the mainstream smoke of popular cigarettes sold in the United States. PMID:24806664

  6. Chicken globin gene transcription is cell lineage specific during the time of the switch

    International Nuclear Information System (INIS)

    Lois, R.; Martinson, H.G.

    1989-01-01

    Posttranscriptional silencing of embryonic globin gene expression occurs during hemoglobin switching in chickens. Here the authors use Percoll density gradients to fractionate the red blood cells of 5-9 day embryos in order to determine the cellular source and the timing of this posttranscriptional process. By means of nuclear run-on transcription in vitro they show that it is within mature primitive cells that production of embryonic globin mRNA is terminated posttranscriptionally. In contrast, young definitive cells produce little (or no) embryonic globin mRNA because of regulation at the transcriptional level. Thus the lineage specificity of embryonic and adult globin gene expression is determined transcriptionally, and the posttranscriptional process described by Landes et al. is a property of the senescing primitive cells, not a mechanism operative in the hemoglobin switch. This conclusion is supported by [ 3 H]leucine incorporation experiments on Percoll-fractionated cells which reveal no posttranscriptional silencing of the embryonic genes during the early stages of the switch. In the course of these studies they have noticed a strong transcriptional pause near the second exon of the globin genes which is induced by 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) and which resembles a natural pause near that position

  7. Morph-specific metabolic rate and the timing of reproductive senescence in a color polymorphic dragon.

    Science.gov (United States)

    Friesen, Christopher R; Johansson, Rasmus; Olsson, Mats

    2017-08-01

    Polymorphism has fascinated biologists for over a century because morphs persist within populations through evolutionary time in spite of showing disparate behavioral and physiological phenotypes; any one morph should go to fixation with the slightest fitness advantage over the others. Surely there must be trade-offs that balance selection on them. The polychromatic morphs of the Australian painted dragon lizard, Ctenophorus pictus, are one such system. The male color morphs of painted dragons have different physiological and behavioral traits including reproductive tactics, hormone levels, and the rate of body condition loss through the reproductive season. Due to their differences in physiology and reproductive tactics, we tested the hypotheses that male morphs would differ in resting metabolic rates (RMRs) and that the morphs' RMR would decline at different rates through the mating season. We found that bib-morphs (yellow gular patch) differ in RMR with bibbed (more aggressive) males having consistently higher RMR than non-bibbed males. Furthermore, we show that male dragons experience a decline in RMR as they age from reproductively active to inactive. We also found that the RMR of bibbed males has higher repeatability than non-bibbed males. Our results reinforce previous hypotheses about the morph-specific costs of bearing a gular patch in painted dragons. © 2017 Wiley Periodicals, Inc.

  8. Three-Year-Olds Understand Appearance and Reality--Just Not about the Same Object at the Same Time

    Science.gov (United States)

    Moll, Henrike; Tomasello, Michael

    2012-01-01

    Young children struggle in the classic tests of appearance versus reality. In the current Study 1, 3-year-olds had to determine which of 2 objects (a deceptive or a nondeceptive one) an adult requested when asking for the "real X" versus "the one that looks like X." In Study 2, children of the same age had to indicate what a single deceptive…

  9. Developmental Change and Time-Specific Variation in Global and Specific Aspects of Self-Concept in Adolescence and Association with Depressive Symptoms

    Science.gov (United States)

    Kuzucu, Yasar; Bontempo, Daniel E.; Hofer, Scott M.; Stallings, Michael C.; Piccinin, Andrea M.

    2014-01-01

    Previous research has demonstrated that adolescents make differential self-evaluations in multiple domains that include physical appearance, academic competence, and peer acceptance. We report growth curve analyses over a seven year period from age 9 to age 16 on the six domains of the Harter Self-Perception Profile for Children. In general, we find little change in self-concept, on average, but do find substantial individual differences in level, rate of change, and time-specific variation in these self- evaluations. The results suggest that sex differences and adoptive status were related to only certain aspects of the participants’ self-concept. Depressive symptoms were found to have significant effects on individual differences in rate of change and on time-specific variation in general self-concept, as well as on some of the specific domains of self-concept. PMID:25143664

  10. Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A.

    Directory of Open Access Journals (Sweden)

    Glòria Arqué

    Full Text Available BACKGROUND: Pathogenic aneuploidies involve the concept of dosage-sensitive genes leading to over- and underexpression phenotypes. Monosomy 21 in human leads to mental retardation and skeletal, immune and respiratory function disturbances. Most of the human condition corresponds to partial monosomies suggesting that critical haploinsufficient genes may be responsible for the phenotypes. The DYRK1A gene is localized on the human chromosome 21q22.2 region, and has been proposed to participate in monosomy 21 phenotypes. It encodes a dual-specificity kinase involved in neuronal development and in adult brain physiology, but its possible role as critical haploinsufficient gene in cognitive function has not been explored. METHODOLOGY/PRINCIPAL FINDINGS: We used mice heterozygous for a Dyrk1A targeted mutation (Dyrk1A+/- to investigate the implication of this gene in the cognitive phenotypes of monosomy 21. Performance of Dyrk1A+/- mice was assayed 1/ in a navigational task using the standard hippocampally related version of the Morris water maze, 2/ in a swimming test designed to reveal potential kinesthetic and stress-related behavioral differences between control and heterozygous mice under two levels of aversiveness (25 degrees C and 17 degrees C and 3/ in a long-term novel object recognition task, sensitive to hippocampal damage. Dyrk1A+/- mice showed impairment in the development of spatial learning strategies in a hippocampally-dependent memory task, they were impaired in their novel object recognition ability and were more sensitive to aversive conditions in the swimming test than euploid control animals. CONCLUSIONS/SIGNIFICANCE: The present results are clear examples where removal of a single gene has a profound effect on phenotype and indicate that haploinsufficiency of DYRK1A might contribute to an impairment of cognitive functions and stress coping behavior in human monosomy 21.

  11. Systemic lipopolysaccharide administration impairs retrieval of context-object discrimination, but not spatial, memory: Evidence for selective disruption of specific hippocampus-dependent memory functions during acute neuroinflammation.

    Science.gov (United States)

    Czerniawski, Jennifer; Miyashita, Teiko; Lewandowski, Gail; Guzowski, John F

    2015-02-01

    Neuroinflammation is implicated in impairments in neuronal function and cognition that arise with aging, trauma, and/or disease. Therefore, understanding the underlying basis of the effect of immune system activation on neural function could lead to therapies for treating cognitive decline. Although neuroinflammation is widely thought to preferentially impair hippocampus-dependent memory, data on the effects of cytokines on cognition are mixed. One possible explanation for these inconsistent results is that cytokines may disrupt specific neural processes underlying some forms of memory but not others. In an earlier study, we tested the effect of systemic administration of bacterial lipopolysaccharide (LPS) on retrieval of hippocampus-dependent context memory and neural circuit function in CA3 and CA1 (Czerniawski and Guzowski, 2014). Paralleling impairment in context discrimination memory, we observed changes in neural circuit function consistent with disrupted pattern separation function. In the current study we tested the hypothesis that acute neuroinflammation selectively disrupts memory retrieval in tasks requiring hippocampal pattern separation processes. Male Sprague-Dawley rats given LPS systemically prior to testing exhibited intact performance in tasks that do not require hippocampal pattern separation processes: novel object recognition and spatial memory in the water maze. By contrast, memory retrieval in a task thought to require hippocampal pattern separation, context-object discrimination, was strongly impaired in LPS-treated rats in the absence of any gross effects on exploratory activity or motivation. These data show that LPS administration does not impair memory retrieval in all hippocampus-dependent tasks, and support the hypothesis that acute neuroinflammation impairs context discrimination memory via disruption of pattern separation processes in hippocampus. Copyright © 2014 Elsevier Inc. All rights reserved.

  12. IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms.

    Science.gov (United States)

    Ashpole, Nicole M; Herron, Jacquelyn C; Mitschelen, Matthew C; Farley, Julie A; Logan, Sreemathi; Yan, Han; Ungvari, Zoltan; Hodges, Erik L; Csiszar, Anna; Ikeno, Yuji; Humphrey, Mary Beth; Sonntag, William E

    2016-02-01

    Advanced aging is associated with increased risk of bone fracture, especially within the vertebrae, which exhibit significant reductions in trabecular bone structure. Aging is also associated with a reduction in circulating levels of insulin-like growth factor (IGF-1). Studies have suggested that the reduction in IGF-1 compromises healthspan, whereas others report that loss of IGF-1 is beneficial because it increases healthspan and lifespan. To date, the effect of decreases in circulating IGF-1 on vertebral bone aging has not been thoroughly investigated. Here, we delineate the consequences of a loss of circulating IGF-1 on vertebral bone aging in male and female Igf(f/f) mice. IGF-1 was reduced at multiple specific time points during the mouse lifespan: early in postnatal development (crossing albumin-cyclic recombinase [Cre] mice with Igf(f/f) mice); and in early adulthood and in late adulthood using hepatic-specific viral vectors (AAV8-TBG-Cre). Vertebrae bone structure was analyzed at 27 months of age using micro-computed tomography (μCT) and quantitative bone histomorphometry. Consistent with previous studies, both male and female mice exhibited age-related reductions in vertebral bone structure. In male mice, reduction of circulating IGF-1 induced at any age did not diminish vertebral bone loss. Interestingly, early-life loss of IGF-1 in females resulted in a 67% increase in vertebral bone volume fraction, as well as increased connectivity density and increased trabecular number. The maintenance of bone structure in the early-life IGF-1-deficient females was associated with increased osteoblast surface and an increased ratio of osteoprotegerin/receptor-activator of NF-κB-ligand (RANKL) levels in circulation. Within 3 months of a loss of IGF-1, there was a 2.2-fold increase in insulin receptor expression within the vertebral bones of our female mice, suggesting that local signaling may compensate for the loss of circulating IGF-1. Together, these data

  13. Development of radiation hardened robot for nuclear facility - Development of real-time stereo object tracking system using the optical correlator

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Eun Soo; Lee, S. H.; Lee, J. S. [Kwangwoon University, Seoul (Korea)

    2000-03-01

    Object tracking, through Centroide method used in the KAERI-M1 Stereo Robot Vision System developed at Atomic Research Center, is too sensitive to target's light variation and because it has a fragility which can't reflect the surrounding background, the application in the actual condition is very limited. Also the correlation method can constitute a relatively stable object tracker in noise features but the digital calculation amount is too massive in image correlation so real time materialization is limited. So the development of Optical Correlation based on Stereo Object Tracking System using high speed optical information processing technique will put stable the real time stereo object tracking system and substantial atomic industrial stereo robot vision system to practical use. This research is about developing real time stereo object tracking algorithm using optical correlation system through the technique which can be applied to Atomic Research Center's KAERI-M1 Stereo Vision Robot which will be used in atomic facility remote operations. And revise the stereo disparity using real time optical correlation technique, and materializing the application of the stereo object tracking algorithm to KAERI-M1 Stereo Robot. 19 refs., 45 figs., 2 tabs. (Author)

  14. A Virtual Object-Location Task for Children: Gender and Videogame Experience Influence Navigation; Age Impacts Memory and Completion Time.

    Science.gov (United States)

    Rodriguez-Andres, David; Mendez-Lopez, Magdalena; Juan, M-Carmen; Perez-Hernandez, Elena

    2018-01-01

    The use of virtual reality-based tasks for studying memory has increased considerably. Most of the studies that have looked at child population factors that influence performance on such tasks have been focused on cognitive variables. However, little attention has been paid to the impact of non-cognitive skills. In the present paper, we tested 52 typically-developing children aged 5-12 years in a virtual object-location task. The task assessed their spatial short-term memory for the location of three objects in a virtual city. The virtual task environment was presented using a 3D application consisting of a 120″ stereoscopic screen and a gamepad interface. Measures of learning and displacement indicators in the virtual environment, 3D perception, satisfaction, and usability were obtained. We assessed the children's videogame experience, their visuospatial span, their ability to build blocks, and emotional and behavioral outcomes. The results indicate that learning improved with age. Significant effects on the speed of navigation were found favoring boys and those more experienced with videogames. Visuospatial skills correlated mainly with ability to recall object positions, but the correlation was weak. Longer paths were related with higher scores of withdrawal behavior, attention problems, and a lower visuospatial span. Aggressiveness and experience with the device used for interaction were related with faster navigation. However, the correlations indicated only weak associations among these variables.

  15. A Virtual Object-Location Task for Children: Gender and Videogame Experience Influence Navigation; Age Impacts Memory and Completion Time

    Science.gov (United States)

    Rodriguez-Andres, David; Mendez-Lopez, Magdalena; Juan, M.-Carmen; Perez-Hernandez, Elena

    2018-01-01

    The use of virtual reality-based tasks for studying memory has increased considerably. Most of the studies that have looked at child population factors that influence performance on such tasks have been focused on cognitive variables. However, little attention has been paid to the impact of non-cognitive skills. In the present paper, we tested 52 typically-developing children aged 5–12 years in a virtual object-location task. The task assessed their spatial short-term memory for the location of three objects in a virtual city. The virtual task environment was presented using a 3D application consisting of a 120″ stereoscopic screen and a gamepad interface. Measures of learning and displacement indicators in the virtual environment, 3D perception, satisfaction, and usability were obtained. We assessed the children’s videogame experience, their visuospatial span, their ability to build blocks, and emotional and behavioral outcomes. The results indicate that learning improved with age. Significant effects on the speed of navigation were found favoring boys and those more experienced with videogames. Visuospatial skills correlated mainly with ability to recall object positions, but the correlation was weak. Longer paths were related with higher scores of withdrawal behavior, attention problems, and a lower visuospatial span. Aggressiveness and experience with the device used for interaction were related with faster navigation. However, the correlations indicated only weak associations among these variables. PMID:29674988

  16. A Virtual Object-Location Task for Children: Gender and Videogame Experience Influence Navigation; Age Impacts Memory and Completion Time

    Directory of Open Access Journals (Sweden)

    David Rodriguez-Andres

    2018-04-01

    Full Text Available The use of virtual reality-based tasks for studying memory has increased considerably. Most of the studies that have looked at child population factors that influence performance on such tasks have been focused on cognitive variables. However, little attention has been paid to the impact of non-cognitive skills. In the present paper, we tested 52 typically-developing children aged 5–12 years in a virtual object-location task. The task assessed their spatial short-term memory for the location of three objects in a virtual city. The virtual task environment was presented using a 3D application consisting of a 120″ stereoscopic screen and a gamepad interface. Measures of learning and displacement indicators in the virtual environment, 3D perception, satisfaction, and usability were obtained. We assessed the children’s videogame experience, their visuospatial span, their ability to build blocks, and emotional and behavioral outcomes. The results indicate that learning improved with age. Significant effects on the speed of navigation were found favoring boys and those more experienced with videogames. Visuospatial skills correlated mainly with ability to recall object positions, but the correlation was weak. Longer paths were related with higher scores of withdrawal behavior, attention problems, and a lower visuospatial span. Aggressiveness and experience with the device used for interaction were related with faster navigation. However, the correlations indicated only weak associations among these variables.

  17. Evaluation of a Chlamydia trachomatis-specific, commercial, real-time PCR for use with ocular swabs.

    Science.gov (United States)

    Pickering, Harry; Holland, Martin J; Last, Anna R; Burton, Matthew J; Burr, Sarah E

    2018-02-20

    Trachoma, the leading infectious cause of blindness worldwide, is caused by conjunctival Chlamydia trachomatis infection. Trachoma is diagnosed clinically by observation of conjunctival inflammation and/or scarring; however, there is evidence that monitoring C. trachomatis infection may be required for elimination programmes. There are many commercial and 'in-house' nucleic acid amplification tests for the detection of C. trachomatis DNA, but the majority have not been validated for use with ocular swabs. This study evaluated a commercial assay, the Fast-Track Vaginal swab kit, using conjunctival samples from trachoma-endemic areas. An objective, biostatistical-based method for binary classification of continuous PCR data was developed, to limit potential user-bias in diagnostic settings. The Fast-Track Vaginal swab assay was run on 210 ocular swab samples from Guinea-Bissau and Tanzania. Fit of individual amplification curves to exponential or sigmoid models, derivative and second derivative of the curves and final fluorescence value were examined for utility in thresholding for determining positivity. The results from the Fast-Track Vaginal swab assay were evaluated against a commercial test (Amplicor CT/NG) and a non-commercial test (in-house droplet digital PCR), both of whose performance has previously been evaluated. Significant evidence of exponential amplification (R 2  > 0.99) and final fluorescence > 0.15 were combined for thresholding. This objective approach identified a population of positive samples, however there were a subset of samples that amplified towards the end of the cycling protocol (at or later than 35 cycles), which were less clearly defined. The Fast-Track Vaginal swab assay showed good sensitivity against the commercial (95.71) and non-commercial (97.18) tests. Specificity was lower against both (90.00 and 96.55, respectively). This study defined a simple, automated protocol for binary classification of continuous, real-time q

  18. Object and Objective Lost?

    DEFF Research Database (Denmark)

    Lopdrup-Hjorth, Thomas

    2015-01-01

    This paper explores the erosion and problematization of ‘the organization’ as a demarcated entity. Utilizing Foucault's reflections on ‘state-phobia’ as a source of inspiration, I show how an organization-phobia has gained a hold within Organization Theory (OT). By attending to the history...... of this organization-phobia, the paper argues that OT has become increasingly incapable of speaking about its core object. I show how organizations went from being conceptualized as entities of major importance to becoming theoretically deconstructed and associated with all kinds of ills. Through this history......, organizations as distinct entities have been rendered so problematic that they have gradually come to be removed from the center of OT. The costs of this have been rather significant. Besides undermining the grounds that gave OT intellectual credibility and legitimacy to begin with, the organization-phobia...

  19. Subjective and objective observation of skin graft recovery on Indonesian local cat with different periods of transplantation time.

    Science.gov (United States)

    Erwin; Gunanti; Handharyani, Ekowati; Noviana, Deni

    2016-05-01

    The success of a skin graft in a cat is highly dependent on the granulation formed by the base of recipient bed. Granulation by the base of recipient bed will form after several days after injury. This research aimed to observe subjective and objective profile of skin graft recovery on forelimb of cats with different periods of donor skin placement. Nine male Indonesian local cats aged 1-2 years old, weighing 3-4 kg were divided into three groups. The first surgery for creating defect wound of 2 cm×2 cm in size was performed in the whole group. The wound was left for several days with the respective interval for each group, respectively: Group I (for 2 days), Group II (for 4 days), and Group III (for 6 days). In the whole group, the second surgery was done by the harvesting skin of thoracic area which then applied on recipient bed of respective groups. The donor skin on Group II was accepted faster compared to Group I and Group III. The donor skin did not show color differences compared to surrounding skin, painless, bright red in bleeding test had faster both hair growth and drug absorption. Test toward the size of donor skin and the effect of drugs did not show a significant difference between each group. The observe subjective and objective profile of skin graft recovery on forelimb of cats on Group II were accepted faster compared to Group I and III.

  20. Take time to make time : What to consider when managing multi-channel sales systems with the objective to increase sales efficiency

    OpenAIRE

    ALM, RAGNAR; KYRÖNLAHTI, RUDY

    2016-01-01

    Traditional sales systems have been disrupted by technological developments. In order to  adapt, companies are changing the way they interact with their customers in business-to-business markets. In the last three decades, multi-channel strategies have spurred the proliferation of different sales channels and new ways of managing sales systems. The purpose of this research was to investigate what should be considered when managing multi-channel sales systems with the objective of increasing s...

  1. Associations between the Objectively Measured Office Environment and Workplace Step Count and Sitting Time: Cross-Sectional Analyses from the Active Buildings Study.

    Science.gov (United States)

    Fisher, Abi; Ucci, Marcella; Smith, Lee; Sawyer, Alexia; Spinney, Richard; Konstantatou, Marina; Marmot, Alexi

    2018-06-01

    Office-based workers spend a large proportion of the day sitting and tend to have low overall activity levels. Despite some evidence that features of the external physical environment are associated with physical activity, little is known about the influence of the spatial layout of the internal environment on movement, and the majority of data use self-report. This study investigated associations between objectively-measured sitting time and activity levels and the spatial layout of office floors in a sample of UK office-based workers. Participants wore activPAL accelerometers for at least three consecutive workdays. Primary outcomes were steps and proportion of sitting time per working hour. Primary exposures were office spatial layout, which was objectively-measured by deriving key spatial variables: 'distance from each workstation to key office destinations', 'distance from participant's workstation to all other workstations', 'visibility of co-workers', and workstation 'closeness'. 131 participants from 10 organisations were included. Fifty-four per cent were female, 81% were white, and the majority had a managerial or professional role (72%) in their organisation. The average proportion of the working hour spent sitting was 0.7 (SD 0.15); participants took on average 444 (SD 210) steps per working hour. Models adjusted for confounders revealed significant negative associations between step count and distance from each workstation to all other office destinations (e.g., B = -4.66, 95% CI: -8.12, -1.12, p office destinations (e.g., B = -6.45, 95% CI: -11.88, -0.41, p office destinations the less they walked, suggesting that changing the relative distance between workstations and other destinations on the same floor may not be the most fruitful target for promoting walking and reducing sitting in the workplace. However, reported effect sizes were very small and based on cross-sectional analyses. The approaches developed in this study could be applied to other

  2. Associations of objectively assessed physical activity and sedentary time with all-cause mortality in US adults: the NHANES study.

    Science.gov (United States)

    Schmid, Daniela; Ricci, Cristian; Leitzmann, Michael F

    2015-01-01

    Sedentary behavior is related to increased mortality risk. Whether such elevated risk can be offset by enhanced physical activity has not been examined using accelerometry data. We examined the relations of sedentary time and physical activity to mortality from any cause using accelerometry data among 1,677 women and men aged 50 years or older from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 cycle with follow-up through December 31, 2006. During an average follow-up of 34.67 months and 4,845.42 person-years, 112 deaths occurred. In multivariate Cox proportional hazard models, greater sedentary time (≥ median of 8.60 hours/day) was associated with increased risk of mortality from any cause (relative risk (RR) = 2.03; 95% confidence interval (CI) = 1.09-3.81). Low level of moderate to vigorous physical activity (physical activity predicted a substantially elevated all-cause mortality risk. As compared with the combination of a low sedentary level and a high level of moderate to vigorous physical activity, the risks of mortality from all causes were 4.38 (95% CI = 1.26-15.16) for low levels of both sedentary time and physical activity, 2.79 (95% CI = 0.77-10.12) for greater time spent sedentary and high physical activity level, and 7.79 (95% CI = 2.26-26.82) for greater time spent sedentary and low physical activity level. The interaction term between sedentary time and moderate to vigorous physical activity was not statistically significant (p = 0.508). Both high levels of sedentary time and low levels of moderate to vigorous physical activity are strong and independent predictors of early death from any cause. Whether a high physical activity level removes the increased risk of all-cause mortality related to sedentariness requires further investigation.

  3. Posttreatment prostatic-specific antigen doubling time as a surrogate endpoint for prostate cancer-specific survival: An analysis of Radiation Therapy Oncology Group Protocol 92-02

    International Nuclear Information System (INIS)

    Valicenti, Richard K.; DeSilvio, Michelle; Hanks, Gerald E.; Porter, Arthur; Brereton, Harmar; Rosenthal, Seth A.; Shipley, William U.; Sandler, Howard M.

    2006-01-01

    Purpose: We evaluated whether posttreatment prostatic-specific antigen doubling time (PSADT) was predictive of prostate cancer mortality by testing the Prentice requirements for a surrogate endpoint. Methods and Materials: We analyzed posttreatment PSA measurements in a cohort of 1,514 men with localized prostate cancer (T2c-4 and PSA level Cox = 0.002), PSADT Cox Cox Cox Cox = 0.4). The significant posttreatment PSADTs were also significant predictors of CSS (p Cox < 0.001). After adjusting for T stage, Gleason score and PSA, all of Prentice's requirements were not met, indicating that the effect of PSADT on CSS was not independent of the randomized treatment. Conclusions: Prostatic specific antigen doubling time is significantly associated with CSS, but did not meet all of Prentice's requirements for a surrogate endpoint of CSS. Thus, the risk of dying of prostate cancer is not fully explained by PSADT

  4. Pain in patients with chronic fatigue syndrome: time for specific pain treatment?

    NARCIS (Netherlands)

    Nijs, J.; Crombez, G.; Meeus, M.; Knoop, H.; Damme, S.V.; Cauwenbergh, V.; Bleijenberg, G.

    2012-01-01

    BACKGROUND: Besides chronic fatigue, patients with chronic fatigue syndrome (CFS) have debilitating widespread pain. Yet pain from CFS is often ignored by clinicians and researchers. OBJECTIVES: To examine whether pain is a unique feature of CFS, or does it share the same underlying mechanisms as

  5. Subjective and objective observation of skin graft recovery on Indonesian local cat with different periods of transplantation time

    Directory of Open Access Journals (Sweden)

    Erwin

    2016-05-01

    Full Text Available Aim: The success of a skin graft in a cat is highly dependent on the granulation formed by the base of recipient bed. Granulation by the base of recipient bed will form after several days after injury. This research aimed to observe subjective and objective profile of skin graft recovery on forelimb of cats with different periods of donor skin placement. Materials and Methods: Nine male Indonesian local cats aged 1-2 years old, weighing 3-4 kg were divided into three groups. The first surgery for creating defect wound of 2 cm×2 cm in size was performed in the whole group. The wound was left for several days with the respective interval for each group, respectively: Group I (for 2 days, Group II (for 4 days, and Group III (for 6 days. In the whole group, the second surgery was done by the harvesting skin of thoracic area which then applied on recipient bed of respective groups. Result: The donor skin on Group II was accepted faster compared to Group I and Group III. The donor skin did not show color differences compared to surrounding skin, painless, bright red in bleeding test had faster both hair growth and drug absorption. Test toward the size of donor skin and the effect of drugs did not show a significant difference between each group. Conclusion: The observe subjective and objective profile of skin graft recovery on forelimb of cats on Group II were accepted faster compared to Group I and III.

  6. Does real-time objective feedback and competition improve performance and quality in manikin CPR training--a prospective observational study from several European EMS.

    Science.gov (United States)

    Smart, J R; Kranz, K; Carmona, F; Lindner, T W; Newton, A

    2015-10-15

    Previous studies have reported that the quality of cardiopulmonary resuscitation (CPR) is important for patient survival. Real time objective feedback during manikin training has been shown to improve CPR performance. Objective measurement could facilitate competition and help motivate participants to improve their CPR performance. The aims of this study were to investigate whether real time objective feedback on manikins helps improve CPR performance and whether competition between separate European Emergency Medical Services (EMS) and between participants at each EMS helps motivation to train. Ten European EMS took part in the study and was carried out in two stages. At Stage 1, each EMS provided 20 pre-hospital professionals. A questionnaire was completed and standardised assessment scenarios were performed for adult and infant out of hospital cardiac arrest (OHCA). CPR performance was objectively measured and recorded but no feedback given. Between Stage 1 and 2, each EMS was given access to manikins for 6 months and instructed on how to use with objective real-time CPR feedback available. Stage 2 was undertaken and was a repeat of Stage 1 with a questionnaire with additional questions relating to usefulness of feedback and the competition nature of the study (using a 10 point Likert score). The EMS that improved the most from Stage 1 to Stage 2 was declared the winner. An independent samples Student t-test was used to analyse the objective CPR metrics with the significance level taken as p Competition between EMS organisations recorded a mean score of 5.8 and competition between participants recorded a mean score of 6.0. The results suggest that the use of real time objective feedback can significantly help improve CPR performance. Competition, especially between participants, appeared to encourage staff to practice and this study suggests that competition might have a useful role to help motivate staff to perform CPR training.

  7. Time dependent emission line profiles in the radially streaming particle model of Seyfert galaxy nuclei and quasi-stellar objects

    Science.gov (United States)

    Hubbard, R.

    1974-01-01

    The radially-streaming particle model for broad quasar and Seyfert galaxy emission features is modified to include sources of time dependence. The results are suggestive of reported observations of multiple components, variability, and transient features in the wings of Seyfert and quasi-stellar emission lines.

  8. Towards a real-time Energy Management System for a Microgrid using a multi-objective genetic algorithm

    DEFF Research Database (Denmark)

    Vergara, Pedro P.; Torquato, Ricardo; Da Silva, Luiz C.P.

    2015-01-01

    This paper proposes a real-time Energy Management System (EMS) for a low voltage (LV) Microgrid (MG). The system operation consists in solving the Unit Commitment (UC) and Economic Load Dispatch (ELD) simultaneously for 24 hours ahead at every 15-minute period. This operation is formulated...

  9. Demand-specific work ability, poor health and working conditions in middle-aged full-time employees

    DEFF Research Database (Denmark)

    Nabe-Nielsen, Kirsten; Thielen, Karsten; Nygaard, Else

    2014-01-01

    -sectional questionnaire data from 3381 full-time employees responding to questions about vocational education, job demands and social support (working conditions), musculoskeletal pain (MSP) and major depression (MD) (poor health) and seven questions about difficulty managing different job demands (reduced demand......We investigated the prevalence of reduced demand-specific work ability, its association with age, gender, education, poor health, and working conditions, and the interaction between poor health and working conditions regarding reduced demand-specific work ability. We used cross...... was associated with six measures of reduced demand-specific work ability. We found no interaction between working conditions and poor health regarding reduced demand-specific work ability....

  10. Specification of real-time automation systems with HybridUML; Spezifikation von Echtzeit-Automatisierungssystemen mit HybridUML

    Energy Technology Data Exchange (ETDEWEB)

    Berkenkoetter, K.; Bisanz, S.; Hannemann, U.; Peleska, J. [Univ. Bremen (Germany)

    2004-07-01

    Complex automation systems require specification formalisms supporting the description of real-time requirements with respect to both discrete and time-continuous observables. For this purpose, the authors have designed the HybridUML specification language. Discrete events, communication, and variable assignments are specified by state machines, timers, and invariant conditions. The time-continuous aspects of system behaviour are described by associating differential equations or time-dependent algebraic conditions with system states. The complexity of large systems is controlled by decomposing the specification into parallel components and hierarchical state machines. Instead of inventing a new language syntax, HybridUML is represented as a profile of the Unified Modeling Language UML 2.0. This allows to re-use the syntactic framework of well-accepted graphical UML constructs and development support provided by various UML case tools. The profile is associated with a precise language semantics linking unambiguous meaning to all HybridUML specifications. As a consequence, HybridUML specifications can be compiled into executable code which is suitable for execution in hard realtime on multi-processor computers. This serves both for the development of automation systems and for specification-based testing in real-time. This paper contains an introduction to HybridUML which is illustrated by an example from the field of automated train control. (orig.)

  11. Sequential Specification of Time-aware Stream Processing Applications (Extended Abstract)

    NARCIS (Netherlands)

    Geuns, S.J.; Hausmans, J.P.H.M.; Bekooij, Marco Jan Gerrit

    2012-01-01

    Automatic parallelization of Nested Loop Programs (NLPs) is an attractive method to create embedded real-time stream processing applications for multi-core systems. However, the description and parallelization of applications with a time dependent functional behavior has not been considered in NLPs.

  12. Factors Associated with Objectively Measured Physical Activity and Sedentary Time of 5-6-Year-Old Children in the STEPS Study

    Science.gov (United States)

    Matarma, Tanja; Tammelin, Tuija; Kulmala, Janne; Koski, Pasi; Hurme, Saija; Lagström, Hanna

    2017-01-01

    Background: The factors associated with preschool-aged children's physical activity (PA) remains unclear. The aim of this cross-sectional study was to examine how different factors were associated with preschool-aged children's objectively measured PA and sedentary time. Methods: The study population was 5-6-year-old children (n = 140) and their…

  13. Objectively measured and self-reported leisure-time sedentary behavior and academic performance in youth: The UP&DOWN Study.

    Science.gov (United States)

    Esteban-Cornejo, Irene; Martinez-Gomez, David; Sallis, James F; Cabanas-Sánchez, Verónica; Fernández-Santos, Jorge; Castro-Piñero, Jose; Veiga, Oscar L

    2015-08-01

    To examine the associations of (i) objectively measured and self-reported sedentary behavior during leisure time with academic performance and (ii) patterns of sedentary behavior with academic performance. This study was conducted with 1146 youth aged 12.5±2.5years in Spain during 2011-2012. Leisure-time sedentary behavior during out-of-school hours was assessed by accelerometry and self-report. Academic performance was assessed through school grades. Objectively measured sedentary leisure-time was not significantly associated with academic performance. Time spent in Internet surfing, listening to music, and sitting without doing anything were negatively associated with all academic performance indicators (β ranging from -0.066 to -0.144; all pacademic indicators (β ranging from -0.085 to -0.148; all pacademic indicators (β ranging from 0.063 to 0.105; all pleisure-time, but not objectively measured sedentary leisure time, may influence academic performance. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. Multi-objective optimization of discrete time-cost tradeoff problem in project networks using non-dominated sorting genetic algorithm

    Science.gov (United States)

    Shahriari, Mohammadreza

    2016-06-01

    The time-cost tradeoff problem is one of the most important and applicable problems in project scheduling area. There are many factors that force the mangers to crash the time. This factor could be early utilization, early commissioning and operation, improving the project cash flow, avoiding unfavorable weather conditions, compensating the delays, and so on. Since there is a need to allocate extra resources to short the finishing time of project and the project managers are intended to spend the lowest possible amount of money and achieve the maximum crashing time, as a result, both direct and indirect costs will be influenced in the project, and here, we are facing into the time value of money. It means that when we crash the starting activities in a project, the extra investment will be tied in until the end date of the project; however, when we crash the final activities, the extra investment will be tied in for a much shorter period. This study is presenting a two-objective mathematical model for balancing compressing the project time with activities delay to prepare a suitable tool for decision makers caught in available facilities and due to the time of projects. Also drawing the scheduling problem to real world conditions by considering nonlinear objective function and the time value of money are considered. The presented problem was solved using NSGA-II, and the effect of time compressing reports on the non-dominant set.

  15. Fashion Objects

    DEFF Research Database (Denmark)

    Andersen, Bjørn Schiermer

    2009-01-01

    -- an outline which at the same time indicates the need for transformations of the Durkheimian model on decisive points. Thus, thirdly, it returns to Durkheim and undertakes to develop his concepts in a direction suitable for a sociological theory of fashion. Finally, it discusses the theoretical implications......This article attempts to create a framework for understanding modern fashion phenomena on the basis of Durkheim's sociology of religion. It focuses on Durkheim's conception of the relation between the cult and the sacred object, on his notion of 'exteriorisation', and on his theory of the social...... symbol in an attempt to describe the peculiar attraction of the fashion object and its social constitution. However, Durkheim's notions of cult and ritual must undergo profound changes if they are to be used in an analysis of fashion. The article tries to expand the Durkheimian cult, radically enlarging...

  16. High-Density Real-Time PCR-Based in Vivo Toxicogenomic Screen to Predict Organ-Specific Toxicity

    Directory of Open Access Journals (Sweden)

    Laszlo G. Puskas

    2011-09-01

    Full Text Available Toxicogenomics, based on the temporal effects of drugs on gene expression, is able to predict toxic effects earlier than traditional technologies by analyzing changes in genomic biomarkers that could precede subsequent protein translation and initiation of histological organ damage. In the present study our objective was to extend in vivo toxicogenomic screening from analyzing one or a few tissues to multiple organs, including heart, kidney, brain, liver and spleen. Nanocapillary quantitative real-time PCR (QRT-PCR was used in the study, due to its higher throughput, sensitivity and reproducibility, and larger dynamic range compared to DNA microarray technologies. Based on previous data, 56 gene markers were selected coding for proteins with different functions, such as proteins for acute phase response, inflammation, oxidative stress, metabolic processes, heat-shock response, cell cycle/apoptosis regulation and enzymes which are involved in detoxification. Some of the marker genes are specific to certain organs, and some of them are general indicators of toxicity in multiple organs. Utility of the nanocapillary QRT-PCR platform was demonstrated by screening different references, as well as discovery of drug-like compounds for their gene expression profiles in different organs of treated mice in an acute experiment. For each compound, 896 QRT-PCR were done: four organs were used from each of the treated four animals to monitor the relative expression of 56 genes. Based on expression data of the discovery gene set of toxicology biomarkers the cardio- and nephrotoxicity of doxorubicin and sulfasalazin, the hepato- and nephrotoxicity of rotenone, dihydrocoumarin and aniline, and the liver toxicity of 2,4-diaminotoluene could be confirmed. The acute heart and kidney toxicity of the active metabolite SN-38 from its less toxic prodrug, irinotecan could be differentiated, and two novel gene markers for hormone replacement therapy were identified

  17. Objective vs. self-reported physical activity and sedentary time: effects of measurement method on relationships with risk biomarkers.

    Directory of Open Access Journals (Sweden)

    Carlos A Celis-Morales

    Full Text Available PURPOSE: Imprecise measurement of physical activity variables might attenuate estimates of the beneficial effects of activity on health-related outcomes. We aimed to compare the cardiometabolic risk factor dose-response relationships for physical activity and sedentary behaviour between accelerometer- and questionnaire-based activity measures. METHODS: Physical activity and sedentary behaviour were assessed in 317 adults by 7-day accelerometry and International Physical Activity Questionnaire (IPAQ. Fasting blood was taken to determine insulin, glucose, triglyceride and total, LDL and HDL cholesterol concentrations and homeostasis model-estimated insulin resistance (HOMA(IR. Waist circumference, BMI, body fat percentage and blood pressure were also measured. RESULTS: For both accelerometer-derived sedentary time (50% lower for the IPAQ-reported compared to the accelerometer-derived measure (p<0.0001 for both interactions. The relationships for moderate-to-vigorous physical activity (MVPA and risk factors were less strong than those observed for sedentary behaviours, but significant negative relationships were observed for both accelerometer and IPAQ MVPA measures with glucose, and insulin and HOMA(IR values (all p<0.05. For accelerometer-derived MVPA only, additional negative relationships were seen with triglyceride, total cholesterol and LDL cholesterol concentrations, BMI, waist circumference and percentage body fat, and a positive relationship was evident with HDL cholesterol (p = 0.0002. Regression coefficients for HOMA(IR, insulin and triglyceride were 43-50% lower for the IPAQ-reported compared to the accelerometer-derived MVPA measure (all p≤0.01. CONCLUSION: Using the IPAQ to determine sitting time and MVPA reveals some, but not all, relationships between these activity measures and metabolic and vascular disease risk factors. Using this self-report method to quantify activity can therefore underestimate the strength of some

  18. Media, journalism, objectivity

    Directory of Open Access Journals (Sweden)

    Vlajki Emil

    2013-01-01

    Full Text Available This is the text around the themes: Media and Journalism, are confronted two directions of opinions: humanism and elitism. Humanism believes that media and journalism must be metaphysically objective: able to tell the truth regardless of time, place and terms of events. Another approach, elitism, is connected with Hegel's philosophy of history. Hegel's conceptual apparatus includes: Idea, History dialectic, 'cunning mind,' self- development and self-realization. In this context, media and journalism are considered as organic unity, an inseparable part of some dialectical totality. More specifically media and journalism can be objective only if they defend concrete ideological assumptions of society to which they belong. Any other understanding of these two concepts is non-objective, mere moralizing and / or demagoguery.

  19. System and Component Software Specification, Run-time Verification and Automatic Test Generation, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The following background technology is described in Part 5: Run-time Verification (RV), White Box Automatic Test Generation (WBATG). Part 5 also describes how WBATG...

  20. Total and domain-specific sitting time among employees in desk-based work settings in Australia.

    Science.gov (United States)

    Bennie, Jason A; Pedisic, Zeljko; Timperio, Anna; Crawford, David; Dunstan, David; Bauman, Adrian; van Uffelen, Jannique; Salmon, Jo

    2015-06-01

    To describe the total and domain-specific daily sitting time among a sample of Australian office-based employees. In April 2010, paper-based surveys were provided to desk-based employees (n=801) in Victoria, Australia. Total daily and domain-specific (work, leisure-time and transport-related) sitting time (minutes/day) were assessed by validated questionnaires. Differences in sitting time were examined across socio-demographic (age, sex, occupational status) and lifestyle characteristics (physical activity levels, body mass index [BMI]) using multiple linear regression analyses. The median (95% confidence interval [CI]) of total daily sitting time was 540 (531-557) minutes/day. Insufficiently active adults (median=578 minutes/day, [95%CI: 564-602]), younger adults aged 18-29 years (median=561 minutes/day, [95%CI: 540-577]) reported the highest total daily sitting times. Occupational sitting time accounted for almost 60% of total daily sitting time. In multivariate analyses, total daily sitting time was negatively associated with age (unstandardised regression coefficient [B]=-1.58, pphysical activity (minutes/week) (B=-0.03, pemployees reported that more than half of their total daily sitting time was accrued in the work setting. Given the high contribution of occupational sitting to total daily sitting time among desk-based employees, interventions should focus on the work setting. © 2014 Public Health Association of Australia.

  1. Propensity score estimation to address calendar time-specific channeling in comparative effectiveness research of second generation antipsychotics.

    Directory of Open Access Journals (Sweden)

    Stacie B Dusetzina

    Full Text Available Channeling occurs when a medication and its potential comparators are selectively prescribed based on differences in underlying patient characteristics. Drug safety advisories can provide new information regarding the relative safety or effectiveness of a drug product which might increase selective prescribing. In particular, when reported adverse effects vary among drugs within a therapeutic class, clinicians may channel patients toward or away from a drug based on the patient's underlying risk for an adverse outcome. If channeling is not identified and appropriately managed it might lead to confounding in observational comparative effectiveness studies.To demonstrate channeling among new users of second generation antipsychotics following a Food and Drug Administration safety advisory and to evaluate the impact of channeling on cardiovascular risk estimates over time.Florida Medicaid data from 2001-2006.Retrospective cohort of adults initiating second generation antipsychotics. We used propensity scores to match olanzapine initiators with other second generation antipsychotic initiators. To evaluate channeling away from olanzapine following an FDA safety advisory, we estimated calendar time-specific propensity scores. We compare the performance of these calendar time-specific propensity scores with conventionally-estimated propensity scores on estimates of cardiovascular risk.Increased channeling away from olanzapine was evident for some, but not all, cardiovascular risk factors and corresponded with the timing of the FDA advisory. Covariate balance was optimized within period and across all periods when using the calendar time-specific propensity score. Hazard ratio estimates for cardiovascular outcomes did not differ across models (Conventional PS: 0.97, 95%CI: 0.81-3.18 versus calendar time-specific PS: 0.93, 95%CI: 0.77-3.04.Changes in channeling over time was evident for several covariates but had limited impact on cardiovascular risk

  2. Modelling and multi-objective optimization of a variable valve-timing spark-ignition engine using polynomial neural networks and evolutionary algorithms

    International Nuclear Information System (INIS)

    Atashkari, K.; Nariman-Zadeh, N.; Goelcue, M.; Khalkhali, A.; Jamali, A.

    2007-01-01

    The main reason for the efficiency decrease at part load conditions for four-stroke spark-ignition (SI) engines is the flow restriction at the cross-sectional area of the intake system. Traditionally, valve-timing has been designed to optimize operation at high engine-speed and wide open throttle conditions. Several investigations have demonstrated that improvements at part load conditions in engine performance can be accomplished if the valve-timing is variable. Controlling valve-timing can be used to improve the torque and power curve as well as to reduce fuel consumption and emissions. In this paper, a group method of data handling (GMDH) type neural network and evolutionary algorithms (EAs) are firstly used for modelling the effects of intake valve-timing (V t ) and engine speed (N) of a spark-ignition engine on both developed engine torque (T) and fuel consumption (Fc) using some experimentally obtained training and test data. Using such obtained polynomial neural network models, a multi-objective EA (non-dominated sorting genetic algorithm, NSGA-II) with a new diversity preserving mechanism are secondly used for Pareto based optimization of the variable valve-timing engine considering two conflicting objectives such as torque (T) and fuel consumption (Fc). The comparison results demonstrate the superiority of the GMDH type models over feedforward neural network models in terms of the statistical measures in the training data, testing data and the number of hidden neurons. Further, it is shown that some interesting and important relationships, as useful optimal design principles, involved in the performance of the variable valve-timing four-stroke spark-ignition engine can be discovered by the Pareto based multi-objective optimization of the polynomial models. Such important optimal principles would not have been obtained without the use of both the GMDH type neural network modelling and the multi-objective Pareto optimization approach

  3. Prolonged activated prothromboplastin time and breed specific variation in haemostatic analytes in healthy adult Bernese Mountain dogs

    DEFF Research Database (Denmark)

    Nielsen, Lise; Wiinberg, Bo; Kjelgaard-Hansen, Mads

    2011-01-01

    Coagulation tests are often performed in dogs suspected of haemostatic dysfunction and are interpreted according to validated laboratory reference intervals (RIs). Breed specific RIs for haematological and biochemical analytes have previously been identified in Bernese Mountain dogs, but it remains...... to be determined if breed specific RIs are necessary for haemostasis tests. Activated prothromboplastin time (aPTT), prothrombin time (PT), selected coagulation factors, D-dimers, fibrinogen, von Willebrand factor and thromboelastography (TEG) were analyzed in healthy Bernese Mountain dogs using the CLSI model...

  4. Specification and Analysis of Soft Real-Time Systems: Quantity and Quality

    NARCIS (Netherlands)

    d' Argenio, P.R.; Katoen, Joost P.; Brinksma, Hendrik

    This paper presents a process algebra for specifying soft real-time constraints in a compositional way. For these soft constraints we take a stochastic point of view and allow arbitrary probability distributions to express delays of activities. The semantics of this process algebra is given in terms

  5. Specific and sensitive diagnosis of syphilis using a real-time PCR for Treponema pallidum

    NARCIS (Netherlands)

    Koek, A. G.; Bruisten, S. M.; Dierdorp, M.; van Dam, A. P.; Templeton, K.

    2006-01-01

    A real-time PCR assay with a Taqman probe was developed that targeted the polA gene of Treponema pallidum. The test was validated using an analytical panel (n = 140) and a clinical panel of genital samples (n = 112) from patients attending a sexually transmitted infections clinic. High sensitivities

  6. Wide variation of prostate-specific antigen doubling time of untreated, clinically localized, low-to-intermediate grade, prostate carcinoma.

    Science.gov (United States)

    Choo, Richard; Klotz, Laurence; Deboer, Gerrit; Danjoux, Cyril; Morton, Gerard C

    2004-08-01

    To assess the prostate specific antigen (PSA) doubling time of untreated, clinically localized, low-to-intermediate grade prostate carcinoma. A prospective single-arm cohort study has been in progress since November 1995 to assess the feasibility of a watchful-observation protocol with selective delayed intervention for clinically localized, low-to-intermediate grade prostate adenocarcinoma. The PSA doubling time was estimated from a linear regression of ln(PSA) against time, assuming a simple exponential growth model. As of March 2003, 231 patients had at least 6 months of follow-up (median 45) and at least three PSA measurements (median 8, range 3-21). The distribution of the doubling time was: 50 years, 56. The median doubling time was 7.0 years; 42% of men had a doubling time of >10 years. The doubling time of untreated clinically localized, low-to-intermediate grade prostate cancer varies widely.

  7. Utilities objectives

    International Nuclear Information System (INIS)

    Cousin, Y.; Fabian, H.U.

    1996-01-01

    The policy of French and german utilities is to make use of nuclear energy as a long term, competitive and environmentally friendly power supply. The world electricity generation is due to double within the next 30 years. In the next 20 to 30 years the necessity of nuclear energy will be broadly recognized. More than for most industries, to deal properly with nuclear energy requires the combination of a consistent political will, of a proper institutional framework, of strong and legitimate control authorities, of a sophisticated industry and of operators with skilled management and human resources. One of the major risk facing nuclear energy is the loss of competitiveness. This can be achieved only through the combination of an optimized design, a consistent standardization, a proper industrial partnership and a stable long term strategy. Although the existing plants in Western Europe are already very safe, the policy is clearly to enhance the safety of the next generation of nuclear plants which are designing today. The French and German utilities have chosen an evolutionary approach based on experience and proven technologies, with an enhanced defense in depth and an objective of easier operation and maintenance. The cost objective is to maintain and improve what has been achieved in the best existing power plants in both countries. This calls for rational choices and optimized design to meet the safety objectives, a strong standardization policy, short construction times, high availability and enough flexibility to enable optimization of the fuel cycle throughout the lifetime of the plants. The conceptual design phase has proven that the French and German teams from industry and from the utilities are able to pursue both the safety and the cost objectives, basing their decision on a rational approach which could be accepted by the safety authorities. (J.S.)

  8. Registration of Space Objects

    Science.gov (United States)

    Schmidt-Tedd, Bernhard

    2017-07-01

    Space objects are subject to registration in order to allocate "jurisdiction and control" over those objects in the sovereign-free environment of outer space. This approach is similar to the registration of ships in view of the high sea and for aircrafts with respect to the international airspace. Registration is one of the basic principles of space law, starting with UN General Assembly Resolution 1721 B (XVI) of December 20, 1961, followed by Resolution 1962 (XVIII) of December 13, 1963, then formulated in Article VIII of the Outer Space Treaty of 1967 and as specified in the Registration Convention of 1975. Registration of space objects can be seen today as a principle of customary international law, relevant for each spacefaring state. Registration is divided into a national and an international level. The State Party establishes a national registry for its space objects, and those registrations have to be communicated via diplomatic channel to the UN Register of space objects. This UN Register is handled by the UN Office for Outer Space Affairs (UNOOSA) and is an open source of information for space objects worldwide. Registration is linked to the so-called launching state of the relevant space object. There might be more than one launching state for the specific launch event, but only one state actor can register a specific space object. The state of registry gains "jurisdiction and control" over the space object and therefore no double registration is permissible. Based on the established UN Space Law, registration practice was subject to some adaptions due to technical developments and legal challenges. After the privatization of the major international satellite organizations, a number of non-registrations had to be faced. The state actors reacted with the UN Registration Practice Resolution of 2007 as elaborated in the Legal Subcommittee of UNCOPUOS, the Committee for the Peaceful Use of Outer Space. In this context an UNOOSA Registration Information

  9. Assessment of Membrane Fluidity Fluctuations during Cellular Development Reveals Time and Cell Type Specificity

    KAUST Repository

    Noutsi, Bakiza Kamal; Gratton, Enrico; Chaieb, Saharoui

    2016-01-01

    Cell membrane is made up of a complex structure of lipids and proteins that diffuse laterally giving rise to what we call membrane fluidity. During cellular development, such as differentiation cell membranes undergo dramatic fluidity changes induced by proteins such as ARC and Cofilin among others. In this study we used the generalized polarization (GP) property of fluorescent probe Laurdan using two-photon microscopy to determine membrane fluidity as a function of time and for various cell lines. A low GP value corresponds to a higher fluidity and a higher GP value is associated with a more rigid membrane. Four different cell lines were monitored such as hN2, NIH3T3, HEK293 and L6 cells. Membrane fluidity was measured at 12h, 72h and 92 h. Our results show significant changes in membrane fluidity among all cell types at different time points. GP values tend to increase significantly within 92 h in hN2 cells and 72 h in NIH3T3 cells and only at 92 h in HEK293 cells. L6 showed a marked decrease in membrane fluidity at 72 h and starts to increase at 92 h. As expected, NIH3T3 cells have more rigid membrane at earlier time points. On the other hand, neurons tend to have the highest membrane fluidity at early time points emphasizing its correlation with plasticity and the need for this malleability during differentiation. This study sheds light on the involvement of membrane fluidity during neuronal differentiation and development of other cell lines.

  10. Assessment of Membrane Fluidity Fluctuations during Cellular Development Reveals Time and Cell Type Specificity

    KAUST Repository

    Noutsi, Bakiza Kamal

    2016-06-30

    Cell membrane is made up of a complex structure of lipids and proteins that diffuse laterally giving rise to what we call membrane fluidity. During cellular development, such as differentiation cell membranes undergo dramatic fluidity changes induced by proteins such as ARC and Cofilin among others. In this study we used the generalized polarization (GP) property of fluorescent probe Laurdan using two-photon microscopy to determine membrane fluidity as a function of time and for various cell lines. A low GP value corresponds to a higher fluidity and a higher GP value is associated with a more rigid membrane. Four different cell lines were monitored such as hN2, NIH3T3, HEK293 and L6 cells. Membrane fluidity was measured at 12h, 72h and 92 h. Our results show significant changes in membrane fluidity among all cell types at different time points. GP values tend to increase significantly within 92 h in hN2 cells and 72 h in NIH3T3 cells and only at 92 h in HEK293 cells. L6 showed a marked decrease in membrane fluidity at 72 h and starts to increase at 92 h. As expected, NIH3T3 cells have more rigid membrane at earlier time points. On the other hand, neurons tend to have the highest membrane fluidity at early time points emphasizing its correlation with plasticity and the need for this malleability during differentiation. This study sheds light on the involvement of membrane fluidity during neuronal differentiation and development of other cell lines.

  11. Time series modeling of pathogen-specific disease probabilities with subsampled data.

    Science.gov (United States)

    Fisher, Leigh; Wakefield, Jon; Bauer, Cici; Self, Steve

    2017-03-01

    Many diseases arise due to exposure to one of multiple possible pathogens. We consider the situation in which disease counts are available over time from a study region, along with a measure of clinical disease severity, for example, mild or severe. In addition, we suppose a subset of the cases are lab tested in order to determine the pathogen responsible for disease. In such a context, we focus interest on modeling the probabilities of disease incidence given pathogen type. The time course of these probabilities is of great interest as is the association with time-varying covariates such as meteorological variables. In this set up, a natural Bayesian approach would be based on imputation of the unsampled pathogen information using Markov Chain Monte Carlo but this is computationally challenging. We describe a practical approach to inference that is easy to implement. We use an empirical Bayes procedure in a first step to estimate summary statistics. We then treat these summary statistics as the observed data and develop a Bayesian generalized additive model. We analyze data on hand, foot, and mouth disease (HFMD) in China in which there are two pathogens of primary interest, enterovirus 71 (EV71) and Coxackie A16 (CA16). We find that both EV71 and CA16 are associated with temperature, relative humidity, and wind speed, with reasonably similar functional forms for both pathogens. The important issue of confounding by time is modeled using a penalized B-spline model with a random effects representation. The level of smoothing is addressed by a careful choice of the prior on the tuning variance. © 2016, The International Biometric Society.

  12. Improving specificity of Bordetella pertussis detection using a four target real-time PCR.

    Directory of Open Access Journals (Sweden)

    Helena Martini

    Full Text Available The incidence of whooping cough, a contagious respiratory disease caused by Bordetella pertussis, is on the rise despite existing vaccination programmes. Similar, though usually milder, respiratory symptoms may be caused by other members of the Bordetella genus: B. parapertussis, B. holmesii, and B. bronchiseptica. Pertussis diagnosis is mostly done using PCR, but the use of multiple targets is necessary in order to differentiate the different Bordetella spp. with sufficient sensitivity and specificity. In this study we evaluate a multiplex PCR assay for the differentiation of B. pertussis from other Bordetella spp., using the targets IS481, IS1001, IS1002, and recA. Moreover, we retrospectively explore the epidemiology of Bordetella spp. infections in Belgium, using the aforementioned assay over a three-year period, from 2013 until 2015.

  13. Improving specificity of Bordetella pertussis detection using a four target real-time PCR

    Science.gov (United States)

    Detemmerman, Liselot; Soetens, Oriane; Yusuf, Erlangga; Piérard, Denis

    2017-01-01

    The incidence of whooping cough, a contagious respiratory disease caused by Bordetella pertussis, is on the rise despite existing vaccination programmes. Similar, though usually milder, respiratory symptoms may be caused by other members of the Bordetella genus: B. parapertussis, B. holmesii, and B. bronchiseptica. Pertussis diagnosis is mostly done using PCR, but the use of multiple targets is necessary in order to differentiate the different Bordetella spp. with sufficient sensitivity and specificity. In this study we evaluate a multiplex PCR assay for the differentiation of B. pertussis from other Bordetella spp., using the targets IS481, IS1001, IS1002, and recA. Moreover, we retrospectively explore the epidemiology of Bordetella spp. infections in Belgium, using the aforementioned assay over a three-year period, from 2013 until 2015. PMID:28403204

  14. Sequence-Specific Model for Peptide Retention Time Prediction in Strong Cation Exchange Chromatography.

    Science.gov (United States)

    Gussakovsky, Daniel; Neustaeter, Haley; Spicer, Victor; Krokhin, Oleg V

    2017-11-07

    The development of a peptide retention prediction model for strong cation exchange (SCX) separation on a Polysulfoethyl A column is reported. Off-line 2D LC-MS/MS analysis (SCX-RPLC) of S. cerevisiae whole cell lysate was used to generate a retention dataset of ∼30 000 peptides, sufficient for identifying the major sequence-specific features of peptide retention mechanisms in SCX. In contrast to RPLC/hydrophilic interaction liquid chromatography (HILIC) separation modes, where retention is driven by hydrophobic/hydrophilic contributions of all individual residues, SCX interactions depend mainly on peptide charge (number of basic residues at acidic pH) and size. An additive model (incorporating the contributions of all 20 residues into the peptide retention) combined with a peptide length correction produces a 0.976 R 2 value prediction accuracy, significantly higher than the additive models for either HILIC or RPLC. Position-dependent effects on peptide retention for different residues were driven by the spatial orientation of tryptic peptides upon interaction with the negatively charged surface functional groups. The positively charged N-termini serve as a primary point of interaction. For example, basic residues (Arg, His, Lys) increase peptide retention when located closer to the N-terminus. We also found that hydrophobic interactions, which could lead to a mixed-mode separation mechanism, are largely suppressed at 20-30% of acetonitrile in the eluent. The accuracy of the final Sequence-Specific Retention Calculator (SSRCalc) SCX model (∼0.99 R 2 value) exceeds all previously reported predictors for peptide LC separations. This also provides a solid platform for method development in 2D LC-MS protocols in proteomics and peptide retention prediction filtering of false positive identifications.

  15. Global, real-time ionosphere specification for end-user communication and navigation products

    Science.gov (United States)

    Tobiska, W.; Carlson, H. C.; Schunk, R. W.; Thompson, D. C.; Sojka, J. J.; Scherliess, L.; Zhu, L.; Gardner, L. C.

    2010-12-01

    Space weather’s effects upon the near-Earth environment are due to dynamic changes in the energy transfer processes from the Sun’s photons, particles, and fields. Of the space environment domains that are affected by space weather, the ionosphere is the key region that affects communication and navigation systems. The Utah State University (USU) Space Weather Center (SWC) is a developer and producer of commercial space weather applications. A key system-level component for providing timely information about the effects of space weather is the Global Assimilation of Ionospheric Measurements (GAIM) system. GAIM, operated by SWC, improves real-time communication and navigation systems by continuously ingesting up to 10,000 slant TEC measurements every 15-minutes from approximately 500 stations. Using a Kalman filter, the background output from the physics-based Ionosphere Forecast Model (IFM) is adjusted to more accurately represent the actual ionosphere. An improved ionosphere leads to more useful derivative products. For example, SWC runs operational code, using GAIM, to calculate and report the global radio high frequency (HF) signal strengths for 24 world cities. This product is updated every 15 minutes at http://spaceweather.usu.edu and used by amateur radio operators. SWC also developed and provides through Apple iTunes the widely used real-time space weather iPhone app called SpaceWx for public space weather education. SpaceWx displays the real-time solar, heliosphere, magnetosphere, thermosphere, and ionosphere drivers to changes in the total electron content, for example. This smart phone app is tip of the “iceberg” of automated systems that provide space weather data; it permits instant understanding of the environment surrounding Earth as it dynamically changes. SpaceWx depends upon a distributed network that connects satellite and ground-based data streams with algorithms to quickly process the measurements into geophysical data, incorporate those

  16. Original article The effect of three-dimensional imaging of well-known objects on time and accuracy of mental rotation

    Directory of Open Access Journals (Sweden)

    Piotr Francuz

    2014-07-01

    Full Text Available Background The purpose of this study was to verify hypotheses concerning the effect of three-dimensional imaging and the canonicity of objects presented in the original position on the reaction time (RT and the accuracy (A of mental rotation task (MRT execution. The classical paradigm of MRT, developed by Shepard and Metzler (1971, was used in the experiment. Participants and procedure One hundred fifty-eight undergraduate students (88 female and 70 male, aged 18-30 years, participated in the experiment. All participants had normal vision or corrected vision, and reported no stereo blindness. The sequential version of the MRT was used in the experiment. Participants answered whether the object observed in the second position was only rotated or both rotated and mirror-reversed, in comparison to its original position. The answer (accuracy and its latency (RT were recorded. Results As predicted by the mental rotation model, both the “U”-shaped A-MRT distribution and the inverted “U”-shaped RT-MRT distribution were found, due to the angular disparity. For the RT-MRT, this effect was more pronounced when the objects were displayed stereoscopically than in a plane, and when the objects were presented in the original position from the canonical orientation rather than an unusual point of view. On the other hand, in the case of the A-MRT, an effect of the orientation of objects presented in the original position on strengthening the relationship between accuracy and angular disparity was found. Conclusions The results indicated that the interactions between the presentation of the objects in the mental rotation task (stereoscopically vs. in a plane and the orientation of the object in its original position (canonically vs. unusual are more complicated than would appear from predictions of classical theories of mental rotation. The results of this study are discussed in relation to the theories of recognition and categorization.

  17. Objectively measured time spent sedentary is associated with insulin resistance independent of overall and central body fat in 9- to 10-year-old Portuguese children

    DEFF Research Database (Denmark)

    Sardinha, Luis B; Andersen, Lars Bo; Anderssen, Sigmund A

    2007-01-01

    OBJECTIVE: We examined the independent relationships between objectively measured physical activity and insulin resistance in Portuguese children. RESEARCH DESIGN AND METHODS: This is a school-based, cross-sectional study in 147 randomly selected girls (aged 9.8 +/- 0.3 years; 27.8 +/- 9.3% body...... fat) and 161 boys (aged 9.8 +/- 0.3 years; 22.0 +/- 9.2% body fat). Physical activity was assessed by the Actigraph accelerometer for 4 days and summarized as time spent sedentary (accelerometer counts ... (beta-coefficient = 0.001 [95% CI 0.0002-0.002]; P = 0.013). Time spent in moderate- and vigorous-intensity physical activity (-0.002 [-0.003 to -0.001]; P = 0.0009) and overall physical activity (-0.001 [-0.008 to 0.003]; P

  18. Specific features of time-dependent Psub(N) approximations in spherical geometry

    International Nuclear Information System (INIS)

    Peltzer, P.; Pucker, N.

    1979-01-01

    Approximations to the time-dependent linear transport equation can result in more serious distortions in the description of the actual physical situation than in the stationary problem. This is demonstrated in detail for the case of a neutron pulse in spherical geometry, treated within a P 1 approximation. One has to pay special attention to the singularity at r = 0 and to the effect of the boundary conditions. Effects similar to those shown here are also to be expected in connection with Psub(N) approximations of higher order. (Auth.)

  19. Formal semantic specifications as implementation blueprints for real-time programming languages

    Science.gov (United States)

    Feyock, S.

    1981-01-01

    Formal definitions of language and system semantics provide highly desirable checks on the correctness of implementations of programming languages and their runtime support systems. If these definitions can give concrete guidance to the implementor, major increases in implementation accuracy and decreases in implementation effort can be achieved. It is shown that of the wide variety of available methods the Hgraph (hypergraph) definitional technique (Pratt, 1975), is best suited to serve as such an implementation blueprint. A discussion and example of the Hgraph technique is presented, as well as an overview of the growing body of implementation experience of real-time languages based on Hgraph semantic definitions.

  20. Development of an On-Line Surgeon-Specific Operating Room Time Prediction System (Experience with the Michigan Surgical Monitors)

    OpenAIRE

    Brown, Allan C.D.; Schmidt, Nancy M.

    1984-01-01

    The development of a micro-computer application for the on-line prediction of surgeon-specific operating room time using an IBM - PCXT is described. The reasons leading to the project, together with an assessment of the Condor 20 relational database management system as the basis for the application are discussed.

  1. Specification and time required for the application of a lime-based render inside historic buildings

    Directory of Open Access Journals (Sweden)

    Vasco Peixoto de Freitas

    2008-01-01

    Full Text Available Intervention in ancient buildings with historical and architectural value requires traditional techniques, such as the use of lime mortars for internal and external wall renderings. In order to ensure the desired performance, these rendering mortars must be rigorously specified and quality controls have to be performed during application. The choice of mortar composition should take account of factors such as compatibility with the substrate, mechanical requirements and water behaviour. The construction schedule, which used to be considered a second order variable, nowadays plays a decisive role in the selection of the rendering technique, given its effects upon costs. How should lime-based mortars be specified? How much time is required for the application and curing of a lime-based render? This paper reflects upon the feasibility of using traditional lime mortars in three-layer renders inside churches and monasteries under adverse hygrothermal conditions and when time is critical. A case study is presented in which internal lime mortar renderings were applied in a church in Northern Portugal, where the very high relative humidity meant that several months were necessary before the drying process was complete.

  2. Caribbean corals house shared and host-specific microbial symbionts over time and space.

    Science.gov (United States)

    Chu, Nathaniel D; Vollmer, Steven V

    2016-08-01

    The rise of coral diseases has triggered a surge of interest in coral microbial communities. But to fully understand how the coral microbiome may cause or respond to disease, we must first understand structure and variation in the healthy coral microbiome. We used 16S rRNA sequencing to characterize the microbiomes of 100 healthy coral colonies from six Caribbean coral species (Acropora cervicornis, A. palmata, Diploria labyrinthiformis, Diploria strigosa, Porites astreoides and P. furcata) across four reefs and three time points over 1 year. We found host species to be the strongest driver of coral microbiome structure across site and time. Analysis of the core microbiome revealed remarkable similarity in the bacterial taxa represented across coral hosts and many bacterial phylotypes shared across all corals sampled. Some of these widespread bacterial taxa have been identified in Pacific corals, indicating that a core coral microbiome may extend across oceans. Core bacterial phylotypes that were unique to each coral were taxonomically diverse, suggesting that different coral hosts provide persistent, divergent niches for bacteria. © 2016 Society for Applied Microbiology and John Wiley & Sons Ltd.

  3. The Optimization of the Time-Cost Tradeoff Problem in Projects with Conditional Activities Using of the Multi-Objective Charged System Search Algorithm (SMOCSS

    Directory of Open Access Journals (Sweden)

    M. K. Sharbatdar

    2016-11-01

    Full Text Available Abstract The appropriate planning and scheduling for reaching the project goals in the most economical way is the very basic issue of the project management. As in each project, the project manager must determine the required activities for the implementation of the project and select the best option in the implementation of each of the activities, in a way that the least final cost and time of the project is achieved. Considering the number of activities and selecting options for each of the activities, usually the selection has not one unique solution, but it consists of a set of solutions that are not preferred to each other and are known as Pareto solutions. On the other hand, in some actual projects, there are activities that their implementation options depend on the implementation of the prerequisite activity and are not applicable using all the implementation options, and even in some cases the implementation or the non-implementation of some activities are also dependent on the prerequisite activity implementation. These projects can be introduced as conditional projects. Much researchs have been conducted for acquiring Pareto solution set, using different methods and algorithms, but in all the done tasks the time-cost optimization of conditional projects is not considered. Thus, in the present study the concept of conditional network is defined along with some practical examples, then an appropriate way to illustrate these networks and suitable time-cost formulation of these are presented. Finally, for some instances of conditional activity networks, conditional project time-cost optimization conducted multi-objectively using known meta-heuristic algorithms such as multi-objective genetic algorithm, multi-objective particle swarm algorithm and multi-objective charged system search algorithm.

  4. Genus-Specific Real-Time PCR and HRM Assays to Distinguish Liriope from Ophiopogon Samples.

    Science.gov (United States)

    Masiero, Eva; Banik, Dipanwita; Abson, John; Greene, Paul; Slater, Adrian; Sgamma, Tiziana

    2017-10-26

    Liriope and Ophiopogon species have a long history of use as traditional medicines across East Asia. They have also become widely used around the world for ornamental and landscaping purposes. The morphological similarities between Liriope and Ophiopogon taxa have made the taxonomy of the two genera problematic and caused confusion about the identification of individual specimens. Molecular approaches could be a useful tool for the discrimination of these two genera in combination with traditional methods. Seventy-five Liriope and Ophiopogon samples from the UK National Plant Collections of Ophiopogon and Liriope were analyzed. The 5' end of the DNA barcode region of the gene for the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase ( rbcLa ) was used for the discrimination of the two genera. A single nucleotide polymorphism (SNP) between the two genera allowed the development of discriminatory tests for genus-level identification based on specific PCR and high-resolution melt curve (HRM) assays. The study highlights the advantage of incorporating DNA barcoding methods into plant identification protocols and provides simple assays that could be used for the quality assurance of commercially traded plants and herbal drugs.

  5. Rapid detection and subtyping of European swine influenza viruses in porcine clinical samples by haemagglutinin- and neuraminidase-specific tetra- and triplex real-time RT-PCRs

    DEFF Research Database (Denmark)

    Henritzi, Dinah; Zhao, Na; Starick, Elke

    2016-01-01

    diagnostic methods which allow for cost-effective large-scale analysis. Methods New SIV haemagglutinin (HA) and neuraminidase (NA) subtype- and lineage-specific multiplex real-time RT-PCRs (RT-qPCR) have been developed and validated with reference virus isolates and clinical samples. Results A diagnostic....... Swine influenza viruses (SIV) are widespread in European domestic pig populations and evolve dynamically. Knowledge regarding occurrence, spread and evolution of potentially zoonotic SIV in Europe is poorly understood. Objectives Efficient SIV surveillance programmes depend on sensitive and specific......Background A diversifying pool of mammalian-adapted influenza A viruses (IAV) with largely unknown zoonotic potential is maintained in domestic swine populations worldwide. The most recent human influenza pandemic in 2009 was caused by a virus with genes originating from IAV isolated from swine...

  6. A framework for inverse planning of beam-on times for 3D small animal radiotherapy using interactive multi-objective optimisation

    International Nuclear Information System (INIS)

    Balvert, Marleen; Den Hertog, Dick; Van Hoof, Stefan J; Granton, Patrick V; Trani, Daniela; Hoffmann, Aswin L; Verhaegen, Frank

    2015-01-01

    Advances in precision small animal radiotherapy hardware enable the delivery of increasingly complicated dose distributions on the millimeter scale. Manual creation and evaluation of treatment plans becomes difficult or even infeasible with an increasing number of degrees of freedom for dose delivery and available image data. The goal of this work is to develop an optimisation model that determines beam-on times for a given beam configuration, and to assess the feasibility and benefits of an automated treatment planning system for small animal radiotherapy.The developed model determines a Pareto optimal solution using operator-defined weights for a multiple-objective treatment planning problem. An interactive approach allows the planner to navigate towards, and to select the Pareto optimal treatment plan that yields the most preferred trade-off of the conflicting objectives. This model was evaluated using four small animal cases based on cone-beam computed tomography images. Resulting treatment plan quality was compared to the quality of manually optimised treatment plans using dose-volume histograms and metrics.Results show that the developed framework is well capable of optimising beam-on times for 3D dose distributions and offers several advantages over manual treatment plan optimisation. For all cases but the simple flank tumour case, a similar amount of time was needed for manual and automated beam-on time optimisation. In this time frame, manual optimisation generates a single treatment plan, while the inverse planning system yields a set of Pareto optimal solutions which provides quantitative insight on the sensitivity of conflicting objectives. Treatment planning automation decreases the dependence on operator experience and allows for the use of class solutions for similar treatment scenarios. This can shorten the time required for treatment planning and therefore increase animal throughput. In addition, this can improve treatment standardisation and

  7. Species-specific detection and quantification of common barnacle larvae from the Japanese coast using quantitative real-time PCR.

    Science.gov (United States)

    Endo, Noriyuki; Sato, Kana; Matsumura, Kiyotaka; Yoshimura, Erina; Odaka, Yukiko; Nogata, Yasuyuki

    2010-11-01

    Species-specific detection and quantification methods for barnacle larvae using quantitative real-time polymerase chain reaction (qPCR) were developed. Species-specific primers for qPCR were designed for 13 barnacle species in the mitochondrial 12S ribosomal RNA gene region. Primer specificity was examined by PCR using template DNA extracted from each of the 13 barnacle species, other unidentified barnacle species, and field collected zooplankton samples. The resulting PCR products comprised single bands following agarose gel electrophoresis when the templates corresponded to primers. The amplifications were highly species-specific even for the field plankton samples. The field plankton samples were subjected to qPCR assay. The calculated DNA contents for each barnacle species were closely correlated with the number of larvae measured by microscopic examination. The method could be applied to quantify barnacle larvae in natural plankton samples.

  8. Effect of objective function on multi-objective inverse planning of radiation therapy

    International Nuclear Information System (INIS)

    Li Guoli; Wu Yican; Song Gang; Wang Shifang

    2006-01-01

    There are two kinds of objective functions in radiotherapy inverse planning: dose distribution-based and Dose-Volume Histogram (DVH)-based functions. The treatment planning in our days is still a trial and error process because the multi-objective problem is solved by transforming it into a single objective problem using a specific set of weights for each object. This work investigates the problem of objective function setting based on Pareto multi-optimization theory, and compares the effect on multi-objective inverse planning of those two kinds of objective functions including calculation time, converge speed, etc. The basis of objective function setting on inverse planning is discussed. (authors)

  9. Demand-specific work ability, poor health and working conditions in middle-aged full-time employees.

    Science.gov (United States)

    Nabe-Nielsen, Kirsten; Thielen, Karsten; Nygaard, Else; Thorsen, Sannie Vester; Diderichsen, Finn

    2014-07-01

    We investigated the prevalence of reduced demand-specific work ability, its association with age, gender, education, poor health, and working conditions, and the interaction between poor health and working conditions regarding reduced demand-specific work ability. We used cross-sectional questionnaire data from 3381 full-time employees responding to questions about vocational education, job demands and social support (working conditions), musculoskeletal pain (MSP) and major depression (MD) (poor health) and seven questions about difficulty managing different job demands (reduced demand-specific work ability). Reduced demand-specific work ability varied from 9% to 19% among the 46-year old and from 11% to 21% among the 56-year old. Age was associated with two, gender with four, and education with all measures of reduced demand-specific work ability. MSP was associated with four and MD was associated with six measures of reduced demand-specific work ability. We found no interaction between working conditions and poor health regarding reduced demand-specific work ability. Copyright © 2014 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  10. Optimization of Time Controlled 6-mercaptopurine Delivery for Site- Specific Targeting to Colon Diseases.

    Science.gov (United States)

    Hude, Rahul U; Jagdale, Swati C

    2016-01-01

    6-MP has short elimination time (Mercaptopurine (6-MP) for treatment of colon diseases. Compression coating technique was used. 32 full factorial design was designed for optimization of the outer coat for the core tablet. For outer coat amount of Eudragit RS 100 and hydroxypropyl methylcellulose (HPMC K100) were employed as independent variables each at three levels while responses evaluated were swelling index and bursting time. Direct compression method was used for tablets formulation. 80% w/w of microcrystalline cellulose and 20% w/w of croscarmellose sodium were found to be optimum concentration for the core tablet. The outer coat of optimized batch (ED) contains 21.05% w/w Eudragit RS 100 and 78.95% w/w HPMC K100 of total polymer weight. In-vitro dissolution study indicated that combination of polymer retards the drug release in gastric region and releases ≥95% of drug in colonic region after ≥7 h. Whereas in case of in-vivo placebo x-ray imaging study had shown that the tablet reaches colonic part after 5±0.5 h providing the proof of arrival in the colon. Stability study indicated that the optimized formulation were physically and chemically stable. Present research work concluded that compression coating by Eudragit RS 100 and HPMC K100 to 6-MP core provides potential colon targeted system with advantages of reduced gastric exposure and enhanced bioavailability. Formulation can be considered as potential and promising candidate for the treatment of colon diseases.

  11. Third trimester ultrasound for fetal macrosomia: optimal timing and institutional specific accuracy.

    Science.gov (United States)

    Parikh, Laura I; Iqbal, Sara N; Jelin, Angie C; Overcash, Rachael T; Tefera, Eshetu; Fries, Melissa H

    2017-11-28

    To determine the performance of third trimester ultrasound in women with suspected fetal macrosomia. We performed a retrospective cohort study of fetal ultrasounds from January 2004 to December 2014 with estimated fetal weight (EFW) between 4000 and 5000 g. We determined accuracy of birth weight prediction for ultrasound performed at less than and greater than 38 weeks, accounting for diabetic status and time between ultrasound and delivery. There were 405 ultrasounds evaluated. One hundred and twelve (27.7%) were performed at less than 38 weeks, 293 (72.3%) at greater than 38 weeks, and 91 (22.5%) were performed in diabetics. Sonographic identification of EFW over 4000 g at less than 38 weeks was associated with higher correlation between EFW and birth weight than ultrasound performed after 38 weeks (71.5 versus 259.4 g, p < .024). EFW to birth weight correlation was within 1.7% of birth weight for ultrasound performed less than 38 weeks and within 6.5% of birth weight for ultrasound performed at greater than 38 weeks. Identification of EFW with ultrasound performed less than 38 weeks has greater reliability of predicting fetal macrosomia at birth than measurements performed later in gestation. EFW to birth weight correlation was more accurate than previous reports.

  12. Pharmacokinetics of colon-specific pH and time-dependent flurbiprofen tablets.

    Science.gov (United States)

    Vemula, Sateesh Kumar; Veerareddy, Prabhakar Reddy; Devadasu, Venkat Ratnam

    2015-09-01

    Present research deals with the development of compression-coated flurbiprofen colon-targeted tablets to retard the drug release in the upper gastro intestinal system, but progressively release the drug in the colon. Flurbiprofen core tablets were prepared by direct compression method and were compression coated using sodium alginate and Eudragit S100. The formulation is optimized based on the in vitro drug release study and further evaluated by X-ray imaging and pharmacokinetic studies in healthy humans for colonic delivery. The optimized formulation showed negligible drug release (4.33 ± 0.06 %) in the initial lag period followed by progressive release (100.78 ± 0.64 %) for 24 h. The X-ray imaging in human volunteers showed that the tablets reached the colon without disintegrating in the upper gastrointestinal tract. The C max of colon-targeted tablets was 12,374.67 ng/ml at T max 10 h, where as in case of immediate release tablets the C max was 15,677.52 ng/ml at T max 3 h, that signifies the ability of compression-coated tablets to target the colon. Development of compression-coated tablets using combination of time-dependent and pH-sensitive approaches was suitable to target the flurbiprofen to colon.

  13. The Specific Features of the Contemporary Russian Foreign Energy Policy Shift in Modern Times

    Directory of Open Access Journals (Sweden)

    Egor S. Leonov

    2015-01-01

    Full Text Available In recent years there has been brewing up a necessity in Russia to change direction of its external energy policy radically as a result of unconstructive and hugely politically charged approach of the EU - main and traditional partner of Russia - to settlement of fundamental issues in bilateral cooperation. First of all this refers to failed efforts to create regional energy security system, based on respective institutions and legal framework, by reason of unwillingness of the EU to respect the Russian standpoint as an exporter of energy resources. As a result, there is a legal vacuum today in energy cooperation between Russia and the EU, which they failed to fill. The current political crisis in Europe, which is caused by accession of the Republic of Crimea to the Russian Federation and events in Ukraine, has aggravated long-standing problems of energy partnership EU-Russia. At the same time active EU policy on diversification of energy sources and supply routes discredits peculiar role of Russia as EU key energy supplier. These factors have triggered a significant revision of Russian interests in favor of eastern direction. A new promising contract with China on 21 May 2014 and memorandum with Turkey on 1 December 2014 are the milestones of the present Russian eastern policy. Both contracts can disrupt power balance on the global energy market. The article deals with background and causes for the present Russian eastern activity.

  14. Bioclim Deliverable D6a: regional climatic characteristics for the European sites at specific times: the dynamical down-scaling

    International Nuclear Information System (INIS)

    2003-01-01

    The overall aim of BIOCLIM is to assess the possible long-term impacts due to climate change on the safety of radioactive waste repositories in deep formations. This aim is addressed through the following specific objectives: - Development of practical and innovative strategies for representing sequential climatic changes to the geosphere-biosphere system for existing sites over central Europe, addressing the timescale of one million years, which is relevant to the geological disposal of radioactive waste. - Exploration and evaluation of the potential effects of climate change on the nature of the biosphere systems used to assess the environmental impact. - Dissemination of information on the new methodologies and the results obtained from the project among the international waste management community for use in performance assessments of potential or planned radioactive waste repositories. The BIOCLIM project is designed to advance the state-of-the-art of biosphere modelling for use in Performance Assessments. Therefore, two strategies are developed for representing sequential climatic changes to geosphere-biosphere systems. The hierarchical strategy successively uses a hierarchy of climate models. These models vary from simple 2-D models, which simulate interactions between a few aspects of the Earth system at a rough surface resolution, through General Circulation Model (GCM) and vegetation model, which simulate in great detail the dynamics and physics of the atmosphere, ocean and biosphere, to regional models, which focus on the European regions and sites of interest. Moreover, rule-based and statistical down-scaling procedures are also considered. Comparisons are provided in terms of climate and vegetation cover at the selected times and for the study regions. The integrated strategy consists of using integrated climate models, representing all the physical mechanisms important for long-term continuous climate variations, to simulate the climate evolution over

  15. Correlates of objectively assessed physical activity and sedentary time in children: a cross-sectional study (The European Youth Heart Study

    Directory of Open Access Journals (Sweden)

    Sardinha Luis B

    2009-09-01

    Full Text Available Abstract Background Identifying leisure time activities performed before and after school that influence time in physical activity (PA and/or time spent sedentary can provide useful information when designing interventions aimed to promote an active lifestyle in young people. The purpose of this study was to examine associations between mode of transportation to school, outdoor play after school, participation in exercise in clubs, and TV viewing with objectively assessed PA and sedentary behaviour in children. Methods A total of 1327 nine- and 15-year-old children from three European countries (Norway, Estonia, Portugal participated as part of the European Youth Heart Study. PA was measured during two weekdays and two weekend days using the MTI accelerometer, and average percent of time in moderate-to-vigorous PA (MVPA and time spent sedentary were derived. Potential correlates were assessed by self-report. Independent associations between self-reported correlates with percent time in MVPA and percent time sedentary were analysed by general linear models, adjusted by age, gender, country, measurement period, monitored days and parental socio-economic status. Results In 9-year-olds, playing outdoors after school was associated with higher percent time in MVPA (P Conclusion Frequency of outdoor play after school is a significant correlate for daily time in MVPA in 9-year-olds, while this correlate is attenuated in favour of participation in sport and exercise in clubs in 15-year-olds. Targeting walking to school or reduced TV viewing time in order to increase time in daily MVPA in children is unlikely to be sufficient. Correlates related to time spent sedentary need further examination.

  16. Scientific profile and professional responsibility of Court-appointed Medical Technical Consultants in Italy: time for a specific educational curriculum?

    Science.gov (United States)

    Conti, Andrea Alberto

    2014-08-20

    Court-appointed Technical Consultants (CTCs) are fundamental figures in the Italian judicial system. CTCs are experts appointed by judges in order to supplement their activities by ascertaining, collecting and analyzing facts concerning the specific subject of a lawsuit. These experts formulate opinions, gather motivations and perform checks to provide clear, objective and irrefutable answers to the questions posed by judges. With direct reference to the medical field, while police doctors (specialists in forensic medicine) follow an academic, dedicated, well-structured educational curriculum, the University specialty school in Forensic Medicine, other medical CTCs, though not infrequently luminaries with one or many medical specialties and professional acknowledgments, may have no specific legal-medicine and juridical expertise, precisely because a similar expertise is not formally required of them. In the light of these considerations, in Italy some professionals of the legal world, and of the health context too, have proposed for medical CTCs targeted educational pathways, which would provide these experts with formal specific qualifications. In synthesis and in conclusion, a full knowledge and a rigorous respect of the rules of legal proceedings emerge as increasingly important characteristics for current and future Court-appointed Technical Consultants, together with a specific educational curriculum.

  17. The Time Course of Task-Specific Memory Consolidation Effects in Resting State Networks

    Science.gov (United States)

    Sami, Saber; Robertson, Edwin M.

    2014-01-01

    Previous studies have reported functionally localized changes in resting-state brain activity following a short period of motor learning, but their relationship with memory consolidation and their dependence on the form of learning is unclear. We investigate these questions with implicit or explicit variants of the serial reaction time task (SRTT). fMRI resting-state functional connectivity was measured in human subjects before the tasks, and 0.1, 0.5, and 6 h after learning. There was significant improvement in procedural skill in both groups, with the group learning under explicit conditions showing stronger initial acquisition, and greater improvement at the 6 h retest. Immediately following acquisition, this group showed enhanced functional connectivity in networks including frontal and cerebellar areas and in the visual cortex. Thirty minutes later, enhanced connectivity was observed between cerebellar nuclei, thalamus, and basal ganglia, whereas at 6 h there was enhanced connectivity in a sensory-motor cortical network. In contrast, immediately after acquisition under implicit conditions, there was increased connectivity in a network including precentral and sensory-motor areas, whereas after 30 min a similar cerebello-thalamo-basal ganglionic network was seen as in explicit learning. Finally, 6 h after implicit learning, we found increased connectivity in medial temporal cortex, but reduction in precentral and sensory-motor areas. Our findings are consistent with predictions that two variants of the SRTT task engage dissociable functional networks, although there are also networks in common. We also show a converging and diverging pattern of flux between prefrontal, sensory-motor, and parietal areas, and subcortical circuits across a 6 h consolidation period. PMID:24623776

  18. Inattentional Deafness: Visual Load Leads to Time-Specific Suppression of Auditory Evoked Responses.

    Science.gov (United States)

    Molloy, Katharine; Griffiths, Timothy D; Chait, Maria; Lavie, Nilli

    2015-12-09

    Due to capacity limits on perception, conditions of high perceptual load lead to reduced processing of unattended stimuli (Lavie et al., 2014). Accumulating work demonstrates the effects of visual perceptual load on visual cortex responses, but the effects on auditory processing remain poorly understood. Here we establish the neural mechanisms underlying "inattentional deafness"--the failure to perceive auditory stimuli under high visual perceptual load. Participants performed a visual search task of low (target dissimilar to nontarget items) or high (target similar to nontarget items) load. On a random subset (50%) of trials, irrelevant tones were presented concurrently with the visual stimuli. Brain activity was recorded with magnetoencephalography, and time-locked responses to the visual search array and to the incidental presence of unattended tones were assessed. High, compared to low, perceptual load led to increased early visual evoked responses (within 100 ms from onset). This was accompanied by reduced early (∼ 100 ms from tone onset) auditory evoked activity in superior temporal sulcus and posterior middle temporal gyrus. A later suppression of the P3 "awareness" response to the tones was also observed under high load. A behavioral experiment revealed reduced tone detection sensitivity under high visual load, indicating that the reduction in neural responses was indeed associated with reduced awareness of the sounds. These findings support a neural account of shared audiovisual resources, which, when depleted under load, leads to failures of sensory perception and awareness. The present work clarifies the neural underpinning of inattentional deafness under high visual load. The findings of near-simultaneous load effects on both visual and auditory evoked responses suggest shared audiovisual processing capacity. Temporary depletion of shared capacity in perceptually demanding visual tasks leads to a momentary reduction in sensory processing of auditory

  19. Objectively measured physical activity levels and sedentary time in 7–9-year-old Estonian schoolchildren: independent associations with body composition parameters

    Directory of Open Access Journals (Sweden)

    Eva-Maria Riso

    2016-04-01

    Full Text Available Abstract Background Sufficient daily physical activity (PA is necessary for physical, social and mental health benefits during growth. Most of the available data on children is based on subjective reports, while only limited data on objective PA and sedentary levels is available for primary school children. Increased PA is also an important health indicator of body composition parameters, especially body adiposity indices. The aim of the present study was to determine objectively the amount of daily PA levels at different intensities and sedentary time in normal-weight (NW and overweight (OW 7–9-year-old boys and girls, and to find associations between objectively measured PA levels and sedentary time with different body composition values. Methods Two hundred and seventy eight (142 boys and 136 girls primary school children aged 7.9 ± 0.7 years participated in this study. Objective PA intensity and sedentary levels were measured over 7 days by accelerometry. Indices of total fat mass (body fat %, sum of skinfolds, fat distribution (waist-to-height ratio and muscular component (fat free mass [FFM] were calculated from measured anthropometric parameters. Results There were no differences (p > 0.05 in PA intensity levels and sedentary time between boys and girls as well as between NW and OW children. About 11 % of children met the current guidelines of at least 60 min per day of moderate-to-vigorous PA (MVPA. Sedentary time was positively and negatively associated (p < 0.05 with all body fat and FFM values, respectively. Moderate and vigorous PA along with MVPA were negatively and positively associated (p < 0.05 with all body fat and FFM indices, respectively. Conclusions The results of present study showed that about 11 % of primary school children were engaged in PA of at least 60 min of MVPA daily. While MVPA is negatively associated with fat mass indices and positively associated with FFM regardless of different

  20. Time-specific measurements of energy deposition from radiation fields in simulated sub-micron tissue volumes

    International Nuclear Information System (INIS)

    Famiano, M.A.

    1997-01-01

    A tissue-equivalent spherical proportional counter is used with a modified amplifier system to measure specific energy deposited from a uniform radiation field for short periods of time (∼1 micros to seconds) in order to extrapolate to dose in sub-micron tissue volumes. The energy deposited during these time intervals is compared to biological repair processes occurring within the same intervals after the initial energy deposition. The signal is integrated over a variable collection time which is adjusted with a square-wave pulse. Charge from particle passages is collected on the anode during the period in which the integrator is triggered, and the signal decays quickly to zero after the integrator feedback switch resets; the process repeats for every triggering pulse. Measurements of energy deposited from x rays, 137 Cs gamma rays, and electrons from a 90 Sr/ 90 Y source for various time intervals are taken. Spectral characteristics as a function of charge collection time are observed and frequency plots of specific energy and collection time-interval are presented. In addition, a threshold energy flux is selected for each radiation type at which the formation of radicals (based on current measurements) in mammalian cells equals the rate at which radicals are repaired

  1. Real-time object recognition in multidimensional images based on joined extended structural tensor and higher-order tensor decomposition methods

    Science.gov (United States)

    Cyganek, Boguslaw; Smolka, Bogdan

    2015-02-01

    In this paper a system for real-time recognition of objects in multidimensional video signals is proposed. Object recognition is done by pattern projection into the tensor subspaces obtained from the factorization of the signal tensors representing the input signal. However, instead of taking only the intensity signal the novelty of this paper is first to build the Extended Structural Tensor representation from the intensity signal that conveys information on signal intensities, as well as on higher-order statistics of the input signals. This way the higher-order input pattern tensors are built from the training samples. Then, the tensor subspaces are built based on the Higher-Order Singular Value Decomposition of the prototype pattern tensors. Finally, recognition relies on measurements of the distance of a test pattern projected into the tensor subspaces obtained from the training tensors. Due to high-dimensionality of the input data, tensor based methods require high memory and computational resources. However, recent achievements in the technology of the multi-core microprocessors and graphic cards allows real-time operation of the multidimensional methods as is shown and analyzed in this paper based on real examples of object detection in digital images.

  2. A Time-Space Domain Information Fusion Method for Specific Emitter Identification Based on Dempster-Shafer Evidence Theory.

    Science.gov (United States)

    Jiang, Wen; Cao, Ying; Yang, Lin; He, Zichang

    2017-08-28

    Specific emitter identification plays an important role in contemporary military affairs. However, most of the existing specific emitter identification methods haven't taken into account the processing of uncertain information. Therefore, this paper proposes a time-space domain information fusion method based on Dempster-Shafer evidence theory, which has the ability to deal with uncertain information in the process of specific emitter identification. In this paper, radars will generate a group of evidence respectively based on the information they obtained, and our main task is to fuse the multiple groups of evidence to get a reasonable result. Within the framework of recursive centralized fusion model, the proposed method incorporates a correlation coefficient, which measures the relevance between evidence and a quantum mechanical approach, which is based on the parameters of radar itself. The simulation results of an illustrative example demonstrate that the proposed method can effectively deal with uncertain information and get a reasonable recognition result.

  3. The "neuro-mapping locator" software. A real-time intraoperative objective paraesthesia mapping tool to evaluate paraesthesia coverage of the painful zone in patients undergoing spinal cord stimulation lead implantation.

    Science.gov (United States)

    Guetarni, F; Rigoard, P

    2015-03-01

    Conventional spinal cord stimulation (SCS) generates paraesthesia, as the efficacy of this technique is based on the relationship between the paraesthesia provided by SCS on the painful zone and an analgesic effect on the stimulated zone. Although this basic postulate is based on clinical evidence, it is clear that this relationship has never been formally demonstrated by scientific studies. There is a need for objective evaluation tools ("transducers") to transpose electrical signals to clinical effects and to guide therapeutic choices. We have developed a software at Poitiers University hospital allowing real-time objective mapping of the paraesthesia generated by SCS lead placement and programming during the implantation procedure itself, on a touch screen interface. The purpose of this article is to describe this intraoperative mapping software, in terms of its concept and technical aspects. The Neuro-Mapping Locator (NML) software is dedicated to patients with failed back surgery syndrome, candidates for SCS lead implantation, to actively participate in the implantation procedure. Real-time geographical localization of the paraesthesia generated by percutaneous or multicolumn surgical SCS lead implanted under awake anaesthesia allows intraoperative lead programming and possibly lead positioning to be modified with the patient's cooperation. Software updates should enable us to refine objectives related to the use of this tool and minimize observational biases. The ultimate goals of NML software should not be limited to optimize one specific device implantation in a patient but also allow to compare instantaneously various stimulation strategies, by characterizing new technical parameters as "coverage efficacy" and "device specificity" on selected subgroups of patients. Another longer-term objective would be to organize these predictive factors into computer science ontologies, which could constitute robust and helpful data for device selection and programming

  4. Abundance of early functional HIV-specific CD8+ T cells does not predict AIDS-free survival time.

    Directory of Open Access Journals (Sweden)

    Ingrid M M Schellens

    Full Text Available BACKGROUND: T-cell immunity is thought to play an important role in controlling HIV infection, and is a main target for HIV vaccine development. HIV-specific central memory CD8(+ and CD4(+ T cells producing IFNgamma and IL-2 have been associated with control of viremia and are therefore hypothesized to be truly protective and determine subsequent clinical outcome. However, the cause-effect relationship between HIV-specific cellular immunity and disease progression is unknown. We investigated in a large prospective cohort study involving 96 individuals of the Amsterdam Cohort Studies with a known date of seroconversion whether the presence of cytokine-producing HIV-specific CD8(+ T cells early in infection was associated with AIDS-free survival time. METHODS AND FINDINGS: The number and percentage of IFNgamma and IL-2 producing CD8(+ T cells was measured after in vitro stimulation with an overlapping Gag-peptide pool in T cells sampled approximately one year after seroconversion. Kaplan-Meier survival analysis and Cox proportional hazard models showed that frequencies of cytokine-producing Gag-specific CD8(+ T cells (IFNgamma, IL-2 or both shortly after seroconversion were neither associated with time to AIDS nor with the rate of CD4(+ T-cell decline. CONCLUSIONS: These data show that high numbers of functional HIV-specific CD8(+ T cells can be found early in HIV infection, irrespective of subsequent clinical outcome. The fact that both progressors and long-term non-progressors have abundant T cell immunity of the specificity associated with low viral load shortly after seroconversion suggests that the more rapid loss of T cell immunity observed in progressors may be a consequence rather than a cause of disease progression.

  5. Remaining useful life estimation for deteriorating systems with time-varying operational conditions and condition-specific failure zones

    Directory of Open Access Journals (Sweden)

    Li Qi

    2016-06-01

    Full Text Available Dynamic time-varying operational conditions pose great challenge to the estimation of system remaining useful life (RUL for the deteriorating systems. This paper presents a method based on probabilistic and stochastic approaches to estimate system RUL for periodically monitored degradation processes with dynamic time-varying operational conditions and condition-specific failure zones. The method assumes that the degradation rate is influenced by specific operational condition and moreover, the transition between different operational conditions plays the most important role in affecting the degradation process. These operational conditions are assumed to evolve as a discrete-time Markov chain (DTMC. The failure thresholds are also determined by specific operational conditions and described as different failure zones. The 2008 PHM Conference Challenge Data is utilized to illustrate our method, which contains mass sensory signals related to the degradation process of a commercial turbofan engine. The RUL estimation method using the sensor measurements of a single sensor was first developed, and then multiple vital sensors were selected through a particular optimization procedure in order to increase the prediction accuracy. The effectiveness and advantages of the proposed method are presented in a comparison with existing methods for the same dataset.

  6. Neutral vs positive oral contrast in diagnosing acute appendicitis with contrast-enhanced CT: sensitivity, specificity, reader confidence and interpretation time

    Science.gov (United States)

    Naeger, D M; Chang, S D; Kolli, P; Shah, V; Huang, W; Thoeni, R F

    2011-01-01

    Objective The study compared the sensitivity, specificity, confidence and interpretation time of readers of differing experience in diagnosing acute appendicitis with contrast-enhanced CT using neutral vs positive oral contrast agents. Methods Contrast-enhanced CT for right lower quadrant or right flank pain was performed in 200 patients with neutral and 200 with positive oral contrast including 199 with proven acute appendicitis and 201 with other diagnoses. Test set disease prevalence was 50%. Two experienced gastrointestinal radiologists, one fellow and two first-year residents blindly assessed all studies for appendicitis (2000 readings) and assigned confidence scores (1=poor to 4=excellent). Receiver operating characteristic (ROC) curves were generated. Total interpretation time was recorded. Each reader's interpretation with the two agents was compared using standard statistical methods. Results Average reader sensitivity was found to be 96% (range 91–99%) with positive and 95% (89–98%) with neutral oral contrast; specificity was 96% (92–98%) and 94% (90–97%). For each reader, no statistically significant difference was found between the two agents (sensitivities p-values >0.6; specificities p-values>0.08), in the area under the ROC curve (range 0.95–0.99) or in average interpretation times. In cases without appendicitis, positive oral contrast demonstrated improved appendix identification (average 90% vs 78%) and higher confidence scores for three readers. Average interpretation times showed no statistically significant differences between the agents. Conclusion Neutral vs positive oral contrast does not affect the accuracy of contrast-enhanced CT for diagnosing acute appendicitis. Although positive oral contrast might help to identify normal appendices, we continue to use neutral oral contrast given its other potential benefits. PMID:20959365

  7. Finite time exergy analysis and multi-objective ecological optimization of a regenerative Brayton cycle considering the impact of flow rate variations

    International Nuclear Information System (INIS)

    Naserian, Mohammad Mahdi; Farahat, Said; Sarhaddi, Faramarz

    2015-01-01

    Highlights: • Defining a dimensionless parameter includes the finite-time and size concepts. • Inserting the concept of exergy of fluid streams into finite-time thermodynamics. • Defining, drawing and modifying of maximum ecological function curve. • Suggesting the appropriate performance zone, according to maximum ecological curve. - Abstract: In this study, the optimal performance of a regenerative Brayton cycle is sought through power and then ecological function maximization using finite-time thermodynamic concept and finite-size components. Multi-objective optimization is used for maximizing the ecological function. Optimizations are performed using genetic algorithm. In order to take into account the finite-time and finite-size concepts in current problem, a dimensionless mass-flow parameter is introduced deploying time variations. The variations of output power, total exergy destruction of the system, and decision variables for the optimum state (maximum ecological function state) are compared to the maximum power state using the dimensionless parameter. The modified ecological function in optimum state is obtained and plotted relating to the dimensionless mass-flow parameter. One can see that the modified ecological function study results in a better performance than that obtained with the maximum power state. Finally, the appropriate performance zone of the heat engine will be obtained

  8. Reported frequency of physical activity in a large epidemiological study: relationship to specific activities and repeatability over time

    Directory of Open Access Journals (Sweden)

    Reeves Gillian K

    2011-06-01

    Full Text Available Abstract Background How overall physical activity relates to specific activities and how reported activity changes over time may influence interpretation of observed associations between physical activity and health. We examine the relationships between various physical activities self-reported at different times in a large cohort study of middle-aged UK women. Methods At recruitment, Million Women Study participants completed a baseline questionnaire including questions on frequency of strenuous and of any physical activity. About 3 years later 589,896 women also completed a follow-up questionnaire reporting the hours they spent on a range of specific activities. Time spent on each activity was used to estimate the associated excess metabolic equivalent hours (MET-hours and this value was compared across categories of physical activity reported at recruitment. Additionally, 18,655 women completed the baseline questionnaire twice, at intervals of up to 4 years; repeatability over time was assessed using the weighted kappa coefficient (κweighted and absolute percentage agreement. Results The average number of hours per week women reported doing specific activities was 14.0 for housework, 4.5 for walking, 3.0 for gardening, 0.2 for cycling, and 1.4 for all strenuous activity. Time spent and the estimated excess MET-hours associated with each activity increased with increasing frequency of any or strenuous physical activity reported at baseline (tests for trend, P weighted = 0.71 for questionnaires administered less than 6 months apart, and 52% (κweighted = 0.51 for questionnaires more than 2 years apart. Corresponding values for any physical activity were 57% (κweighted = 0.67 and 47% (κweighted = 0.58. Conclusions In this cohort, responses to simple questions on the frequency of any physical activity and of strenuous activity asked at baseline were associated with hours spent on specific activities and the associated estimated excess MET

  9. Multi-Objective Optimization of Building Energy Design to Reconcile Collective and Private Perspectives: CO2-eq vs. Discounted Payback Time

    Directory of Open Access Journals (Sweden)

    Mohamed Hamdy

    2017-07-01

    Full Text Available Building energy design is a multi-objective optimization problem where collective and private perspectives conflict each other. For instance, whereas the collectivity pursues the minimization of environmental impact, the private pursues the maximization of financial viability. Solving such trade-off design problems usually involves a big computational cost for exploring a huge solution domain including a large number of design options. To reduce that computational cost, a bi-objective simulation-based optimization algorithm, developed in a previous study, is applied in the present investigation. The algorithm is implemented for minimizing the CO2-eq emissions and the discounted payback time (DPB of a single-family house in cold climate, where 13,456 design solutions including building envelope and heating system options are explored and compared to a predefined reference case. The whole building life is considered by assuming a calculation period of 30 years. The results show that the type of heating system significantly affects energy performance; notably, the ground source heat pump leads to the highest reduction in CO2-eq emissions, around 1300 kgCO2-eq/m2, with 17 year DPB; the oil fire boiler can provide the lowest DPB, equal to 8.5 years, with 850 kgCO2-eq/m2 reduction. In addition, it is shown that using too high levels of thermal insulation is not an effective solution as it causes unacceptable levels of summertime overheating. Finally a multi-objective decision making approach is proposed in order to enable the stakeholders to choice among the optimal solutions according to the weight given to each objective, and thus to each perspective.

  10. Time-wise change in neck pain in response to rehabilitation with specific resistance training: implications for exercise prescription.

    Science.gov (United States)

    Zebis, Mette K; Andersen, Christoffer H; Sundstrup, Emil; Pedersen, Mogens T; Sjøgaard, Gisela; Andersen, Lars L

    2014-01-01

    To determine the time-wise effect of specific resistance training on neck pain among industrial technicians with frequent neck pain symptoms. Secondary analysis of a parallel-group cluster randomized controlled trial of 20 weeks performed at two large industrial production units in Copenhagen, Denmark. Women with neck pain >30 mm VAS (N = 131) were included in the present analysis. The training group (N = 77) performed specific resistance training for the neck/shoulder muscles three times a week, and the control group (N = 54) received advice to stay active. Participants of both groups registered neck pain intensity (0-100 mm VAS) once a week. Neck pain intensity was 55 mm (SD 23) at baseline. There was a significant group by time interaction for neck pain (F-value 2.61, Pchange in pain showed three phases; a rapid decrease in the training group compared with the control group during the initial 7 weeks, a slower decrease in pain during the following weeks (week 8-15), and a plateau during the last weeks (week 16-20). Adherence to training followed a two-phase pattern, i.e. weekly participation rate was between 70-86% during the initial 7 weeks, dropping towards 55-63% during the latter half of the training period. Four weeks of specific resistance training reduced neck pain significantly, but 15 weeks is required to achieve maximal pain reduction. The time-wise change in pain followed a three-phase pattern with a rapid effect during the initial 7 weeks followed by a slower but still positive effect, and finally a plateau from week 15 and onwards. Decreased participation rate may explain the decreased efficacy during the latter phase of the intervention.

  11. Real-Time Amplitude and Phase Imaging of Optically Opaque Objects by Combining Full-Field Off-Axis Terahertz Digital Holography with Angular Spectrum Reconstruction

    Science.gov (United States)

    Yamagiwa, Masatomo; Ogawa, Takayuki; Minamikawa, Takeo; Abdelsalam, Dahi Ghareab; Okabe, Kyosuke; Tsurumachi, Noriaki; Mizutani, Yasuhiro; Iwata, Testuo; Yamamoto, Hirotsugu; Yasui, Takeshi

    2018-06-01

    Terahertz digital holography (THz-DH) has the potential to be used for non-destructive inspection of visibly opaque soft materials due to its good immunity to optical scattering and absorption. Although previous research on full-field off-axis THz-DH has usually been performed using Fresnel diffraction reconstruction, its minimum reconstruction distance occasionally prevents a sample from being placed near a THz imager to increase the signal-to-noise ratio in the hologram. In this article, we apply the angular spectrum method (ASM) for wavefront reconstruction in full-filed off-axis THz-DH because ASM is more accurate at short reconstruction distances. We demonstrate real-time phase imaging of a visibly opaque plastic sample with a phase resolution power of λ/49 at a frame rate of 3.5 Hz in addition to real-time amplitude imaging. We also perform digital focusing of the amplitude image for the same object with a depth selectivity of 447 μm. Furthermore, 3D imaging of visibly opaque silicon objects was achieved with a depth precision of 1.7 μm. The demonstrated results indicate the high potential of the proposed method for in-line or in-process non-destructive inspection of soft materials.

  12. Real-Time Amplitude and Phase Imaging of Optically Opaque Objects by Combining Full-Field Off-Axis Terahertz Digital Holography with Angular Spectrum Reconstruction

    Science.gov (United States)

    Yamagiwa, Masatomo; Ogawa, Takayuki; Minamikawa, Takeo; Abdelsalam, Dahi Ghareab; Okabe, Kyosuke; Tsurumachi, Noriaki; Mizutani, Yasuhiro; Iwata, Testuo; Yamamoto, Hirotsugu; Yasui, Takeshi

    2018-04-01

    Terahertz digital holography (THz-DH) has the potential to be used for non-destructive inspection of visibly opaque soft materials due to its good immunity to optical scattering and absorption. Although previous research on full-field off-axis THz-DH has usually been performed using Fresnel diffraction reconstruction, its minimum reconstruction distance occasionally prevents a sample from being placed near a THz imager to increase the signal-to-noise ratio in the hologram. In this article, we apply the angular spectrum method (ASM) for wavefront reconstruction in full-filed off-axis THz-DH because ASM is more accurate at short reconstruction distances. We demonstrate real-time phase imaging of a visibly opaque plastic sample with a phase resolution power of λ/49 at a frame rate of 3.5 Hz in addition to real-time amplitude imaging. We also perform digital focusing of the amplitude image for the same object with a depth selectivity of 447 μm. Furthermore, 3D imaging of visibly opaque silicon objects was achieved with a depth precision of 1.7 μm. The demonstrated results indicate the high potential of the proposed method for in-line or in-process non-destructive inspection of soft materials.

  13. Object tracking mask-based NLUT on GPUs for real-time generation of holographic videos of three-dimensional scenes.

    Science.gov (United States)

    Kwon, M-W; Kim, S-C; Yoon, S-E; Ho, Y-S; Kim, E-S

    2015-02-09

    A new object tracking mask-based novel-look-up-table (OTM-NLUT) method is proposed and implemented on graphics-processing-units (GPUs) for real-time generation of holographic videos of three-dimensional (3-D) scenes. Since the proposed method is designed to be matched with software and memory structures of the GPU, the number of compute-unified-device-architecture (CUDA) kernel function calls and the computer-generated hologram (CGH) buffer size of the proposed method have been significantly reduced. It therefore results in a great increase of the computational speed of the proposed method and enables real-time generation of CGH patterns of 3-D scenes. Experimental results show that the proposed method can generate 31.1 frames of Fresnel CGH patterns with 1,920 × 1,080 pixels per second, on average, for three test 3-D video scenarios with 12,666 object points on three GPU boards of NVIDIA GTX TITAN, and confirm the feasibility of the proposed method in the practical application of electro-holographic 3-D displays.

  14. A Comparison of Subjective and Objective Job Demands and Fit with Personal Resources as Predictors of Retirement Timing in a National U.S. Sample.

    Science.gov (United States)

    Sonnega, Amanda; Helppie-McFall, Brooke; Hudomiet, Peter; Willis, Robert J; Fisher, Gwenith G

    2017-12-19

    Population aging and attendant pressures on public budgets have spurred considerable interest in understanding factors that influence retirement timing. A range of sociodemographic and economic characteristics predict both earlier and later retirement. Less is known about the role of job characteristics on the work choices of older workers. Researchers are increasingly using the subjective ratings of job characteristics available in the Health and Retirement Study in conjunction with more objective measures of job characteristics from the Occupational Information Network (O*NET) database. Employing a theoretically-informed model of job demands-personal resources fit, we constructed mismatch measures between resources and job demands (both subjectively and objectively assessed) in physical, emotional, and cognitive domains. When we matched comparable measures across the two data sources in the domains of physical, emotional, and cognitive job demands, we found that both sources of information held predictive power in relation to retirement timing. Physical and emotional but not cognitive mismatch were associated with earlier retirement. We discuss theoretical and practical implications of these findings and directions for future research.

  15. A Wavelet-Enhanced PWTD-Accelerated Time-Domain Integral Equation Solver for Analysis of Transient Scattering from Electrically Large Conducting Objects

    KAUST Repository

    Liu, Yang

    2018-02-26

    A wavelet-enhanced plane-wave time-domain (PWTD) algorithm for efficiently and accurately solving time-domain surface integral equations (TD-SIEs) on electrically large conducting objects is presented. The proposed scheme reduces the memory requirement and computational cost of the PWTD algorithm by representing the PWTD ray data using local cosine wavelet bases (LCBs) and performing PWTD operations in the wavelet domain. The memory requirement and computational cost of the LCB-enhanced PWTD-accelerated TD-SIE solver, when applied to the analysis of transient scattering from smooth quasi-planar objects with near-normal incident pulses, scale nearly as O(Ns log Ns) and O(Ns 1.5 ), respectively. Here, Ns denotes the number of spatial unknowns. The efficiency and accuracy of the proposed scheme are demonstrated through its applications to the analysis of transient scattering from a 185 wave-length-long NASA almond and a 123-wavelength long Air-bus-A320 model.

  16. Time to Death after Terminal Withdrawal of Mechanical Ventilation: Specific Respiratory and Physiologic Parameters May Inform Physician Predictions.

    Science.gov (United States)

    Long, Ann C; Muni, Sarah; Treece, Patsy D; Engelberg, Ruth A; Nielsen, Elizabeth L; Fitzpatrick, Annette L; Curtis, J Randall

    2015-12-01

    Discussions about withdrawal of life-sustaining therapies often include family members of critically ill patients. These conversations should address essential components of the dying process, including expected time to death after withdrawal. The study objective was to aid physician communication about the dying process by identifying predictors of time to death after terminal withdrawal of mechanical ventilation. We conducted an observational analysis from a single-center, before-after evaluation of an intervention to improve palliative care. We studied 330 patients who died after terminal withdrawal of mechanical ventilation. Predictors included patient demographics, laboratory, respiratory, and physiologic variables, and medication use. The median time to death for the entire cohort was 0.58 hours (interquartile range (IQR) 0.22-2.25 hours) after withdrawal of mechanical ventilation. Using Cox regression, independent predictors of shorter time to death included higher positive end-expiratory pressure (per 1 cm H2O hazard ratio [HR], 1.07; 95% CI 1.04-1.11); higher static pressure (per 1 cm H2O HR, 1.03; 95% CI 1.01-1.04); extubation prior to death (HR, 1.41; 95% CI 1.06-1.86); and presence of diabetes (HR, 1.75; 95% CI 1.25-2.44). Higher noninvasive mean arterial pressure predicted longer time to death (per 1 mmHg HR, 0.98; 95% CI 0.97-0.99). Comorbid illness and key respiratory and physiologic parameters may inform physician predictions of time to death after withdrawal of mechanical ventilation. An understanding of the predictors of time to death may facilitate discussions with family members of dying patients and improve communication about end-of-life care.

  17. Hybrid Pareto artificial bee colony algorithm for multi-objective single machine group scheduling problem with sequence-dependent setup times and learning effects.

    Science.gov (United States)

    Yue, Lei; Guan, Zailin; Saif, Ullah; Zhang, Fei; Wang, Hao

    2016-01-01

    Group scheduling is significant for efficient and cost effective production system. However, there exist setup times between the groups, which require to decrease it by sequencing groups in an efficient way. Current research is focused on a sequence dependent group scheduling problem with an aim to minimize the makespan in addition to minimize the total weighted tardiness simultaneously. In most of the production scheduling problems, the processing time of jobs is assumed as fixed. However, the actual processing time of jobs may be reduced due to "learning effect". The integration of sequence dependent group scheduling problem with learning effects has been rarely considered in literature. Therefore, current research considers a single machine group scheduling problem with sequence dependent setup times and learning effects simultaneously. A novel hybrid Pareto artificial bee colony algorithm (HPABC) with some steps of genetic algorithm is proposed for current problem to get Pareto solutions. Furthermore, five different sizes of test problems (small, small medium, medium, large medium, large) are tested using proposed HPABC. Taguchi method is used to tune the effective parameters of the proposed HPABC for each problem category. The performance of HPABC is compared with three famous multi objective optimization algorithms, improved strength Pareto evolutionary algorithm (SPEA2), non-dominated sorting genetic algorithm II (NSGAII) and particle swarm optimization algorithm (PSO). Results indicate that HPABC outperforms SPEA2, NSGAII and PSO and gives better Pareto optimal solutions in terms of diversity and quality for almost all the instances of the different sizes of problems.

  18. Analysis of classical time-trial performance and technique-specific physiological determinants in elite female cross-country skiers

    Directory of Open Access Journals (Sweden)

    Øyvind Sandbakk

    2016-08-01

    Full Text Available The present study investigated the contribution of performance on uphill, flat, and downhill sections to overall performance in an international 10-km classical time-trial in elite female cross-country skiers, as well as the relationships between performance on snow and laboratory-measured physiological variables in the double poling (DP and diagonal (DIA techniques. Ten elite female cross-country skiers were continuously measured by a global positioning system device during an international 10-km cross-country skiing time-trial in the classical technique. One month prior to the race, all skiers performed a 5-min submaximal and 3-min self-paced performance test while roller skiing on a treadmill, both in the DP and DIA techniques. The time spent on uphill (r=0.98 and flat (r=0.91 sections of the race correlated most strongly with the overall 10-km performance (both p<0.05. Approximately 56% of the racing time was spent uphill, and stepwise multiple regression revealed that uphill time explained 95.5% of the variance in overall performance (p<0.001. Distance covered during the 3-min roller-skiing test and body-mass normalized peak oxygen uptake (VO2peak in both techniques showed the strongest correlations with overall time-trial performance (r=0.66-0.78, with DP capacity tending to have greatest impact on the flat and DIA capacity on uphill terrain (all p<0.05. Our present findings reveal that the time spent uphill most strongly determine classical time-trial performance, and that the major portion of the performance differences among elite female cross-country skiers can be explained by variations in technique-specific aerobic power.

  19. Examination of mid-intervention mediating effects on objectively assessed sedentary time among children in the Transform-Us! cluster-randomized controlled trial.

    Science.gov (United States)

    Carson, Valerie; Salmon, Jo; Arundell, Lauren; Ridgers, Nicola D; Cerin, Ester; Brown, Helen; Hesketh, Kylie D; Ball, Kylie; Chinapaw, Mai; Yildirim, Mine; Daly, Robin M; Dunstan, David W; Crawford, David

    2013-05-20

    The optimal targets and strategies for effectively reducing sedentary behavior among young people are unknown. Intervention research that explores changes in mediated effects as well as in outcome behaviors is needed to help inform more effective interventions. Therefore, the purpose of this study was to examine the mid-intervention mediating effects on children's objectively assessed classroom and total weekday sedentary time in the Transform-Us! intervention. The results are based on 293 children, aged 7- to 9-years-old at baseline, from 20 schools in Melbourne, Australia. Each school was randomly allocated to one of four groups, which targeted reducing sedentary time in the school and family settings (SB; n = 74), increasing or maintaining moderate- to vigorous-intensity physical activity in the school and family settings (PA; n = 75), combined SB and PA (SB + PA; n = 80), or the current practice control (C; n = 64). Baseline and mid-intervention data (5-9 months) were collected in 2010 and analyzed in 2012. Classroom and total weekday sedentary time was objectively assessed using ActiGraph accelerometers. The hypothesized mediators including, child enjoyment, parent and teacher outcome expectancies, and child perceived access to standing opportunities in the classroom environment, were assessed by questionnaire. The SB + PA group spent 13.3 min/day less in weekday sedentary time at mid-intervention compared to the control group. At mid-intervention, children in the SB group had higher enjoyment of standing in class (0.9 units; 5-unit scale) and all intervention groups had more positive perceptions of access to standing opportunities in the classroom environment (0.3-0.4 units; 3-unit scale), compared to the control group. However, none of the hypothesized mediator variables had an effect on sedentary time; thus, no mediating effects were observed. While beneficial intervention effects were observed on some hypothesized mediating

  20. On the age-specific correlation between fertility and female employment: Heterogeneity over space and time in OECD countries

    Directory of Open Access Journals (Sweden)

    Uta Brehm

    2015-03-01

    Full Text Available Background: Though there has been profound research on the curious change in correlation between total fertility rate (TFR and female labor force participation (FLP in the mid-1980s, aspects of the compositional character of age-specific effects and the nature of countries' heterogeneity have been neglected. Objective: The present paper aims to contribute to filling this gap by analyzing annual total fertility rates and their equivalents for four age groups between 20 and 39 years as well as the respective lagged FLP from 17 OECD countries between 1985 and 2010. Methods: Random Intercept and Random Coefficient Models are applied, allowing us to assess both effects and country heterogeneity in slopes and intercepts. Results: The analyses reveal that the development of the correlation between FLP and TFR after 1985 is comprised of very different relations between age-specific fertility and labor participation. The youngest group's situation is determined by a decrease in both fertility and FLP, while countries' effects differ increasingly. The oldest women's fertility decisions seem to be detached from labor market influences, though country variation is high. Women in their late 20s and early 30s, in contrast, appear to be most affected by the incompatibility of childbearing and gainful employment. Though these effects seem to have overcome their low points during the mid-1990s, only women in their early 30s show country-convergence. Conclusions: The results highlight the fact that total and age-specific fertility behavior, FLP-effects and country variances are distinct concepts that add considerably to the broad understanding of the correlation between fertility and FLP.

  1. Impact of habitat-specific GPS positional error on detection of movement scales by first-passage time analysis.

    Directory of Open Access Journals (Sweden)

    David M Williams

    Full Text Available Advances in animal tracking technologies have reduced but not eliminated positional error. While aware of such inherent error, scientists often proceed with analyses that assume exact locations. The results of such analyses then represent one realization in a distribution of possible outcomes. Evaluating results within the context of that distribution can strengthen or weaken our confidence in conclusions drawn from the analysis in question. We evaluated the habitat-specific positional error of stationary GPS collars placed under a range of vegetation conditions that produced a gradient of canopy cover. We explored how variation of positional error in different vegetation cover types affects a researcher's ability to discern scales of movement in analyses of first-passage time for white-tailed deer (Odocoileus virginianus. We placed 11 GPS collars in 4 different vegetative canopy cover types classified as the proportion of cover above the collar (0-25%, 26-50%, 51-75%, and 76-100%. We simulated the effect of positional error on individual movement paths using cover-specific error distributions at each location. The different cover classes did not introduce any directional bias in positional observations (1 m≤mean≤6.51 m, 0.24≤p≤0.47, but the standard deviation of positional error of fixes increased significantly with increasing canopy cover class for the 0-25%, 26-50%, 51-75% classes (SD = 2.18 m, 3.07 m, and 4.61 m, respectively and then leveled off in the 76-100% cover class (SD = 4.43 m. We then added cover-specific positional errors to individual deer movement paths and conducted first-passage time analyses on the noisy and original paths. First-passage time analyses were robust to habitat-specific error in a forest-agriculture landscape. For deer in a fragmented forest-agriculture environment, and species that move across similar geographic extents, we suggest that first-passage time analysis is robust with regard to

  2. Timing of APC/C substrate degradation is determined by fzy/fzr specificity of destruction boxes

    OpenAIRE

    Zur, Amit; Brandeis, Michael

    2002-01-01

    The anaphase promoting complex/cyclosome (APC/C), activated by fzy and fzr, degrades cell cycle proteins that carry RXXL or KEN destruction boxes (d-boxes). APC/C substrates regulate sequential events and must be degraded in the correct order during mitosis and G1. We studied how d-boxes determine APC/Cfzy/APC/Cfzr specificity and degradation timing. Cyclin B1 has an RXXL box and is degraded by both APC/Cfzy and APC/Cfzr; fzy has a KEN box and is degraded by APC/Cfzr only. We characterized th...

  3. Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin

    Science.gov (United States)

    Migliarini, Sara; Pacini, Giulia; Pasqualetti, Massimo

    2015-01-01

    Serotonin has been gaining increasing attention during the last two decades due to the dual function of this monoamine as key regulator during critical developmental events and as neurotransmitter. Importantly, unbalanced serotonergic levels during critical temporal phases might contribute to the onset of neuropsychiatric disorders, such as schizophrenia and autism. Despite increasing evidences from both animal models and human genetic studies have underpinned the importance of serotonin homeostasis maintenance during central nervous system development and adulthood, the precise role of this molecule in time-specific activities is only beginning to be elucidated. Serotonin synthesis is a 2-step process, the first step of which is mediated by the rate-limiting activity of Tph enzymes, belonging to the family of aromatic amino acid hydroxylases and existing in two isoforms, Tph1 and Tph2, responsible for the production of peripheral and brain serotonin, respectively. In the present study, we generated and validated a conditional knockout mouse line, Tph2 flox/flox, in which brain serotonin can be effectively ablated with time specificity. We demonstrated that the Cre-mediated excision of the third exon of Tph2 gene results in the production of a Tph2 null allele in which we observed the near-complete loss of brain serotonin, as well as the growth defects and perinatal lethality observed in serotonin conventional knockouts. We also revealed that in mice harbouring the Tph2 null allele, but not in wild-types, two distinct Tph2 mRNA isoforms are present, namely Tph2Δ3 and Tph2Δ3Δ4, with the latter showing an in-frame deletion of amino acids 84–178 and coding a protein that could potentially retain non-negligible enzymatic activity. As we could not detect Tph1 expression in the raphe, we made the hypothesis that the Tph2Δ3Δ4 isoform can be at the origin of the residual, sub-threshold amount of serotonin detected in the brain of Tph2 null/null mice. Finally, we set

  4. Sequence-specific validation of LAMP amplicons in real-time optomagnetic detection of Dengue serotype 2 synthetic DNA

    DEFF Research Database (Denmark)

    Minero, Gabriel Khose Antonio; Nogueira, Catarina; Rizzi, Giovanni

    2017-01-01

    We report on an optomagnetic technique optimised for real-time molecular detection of Dengue fever virus under ideal as well as non-ideal laboratory conditions using two different detection approaches. The first approach is based on the detection of the hydrodynamic volume of streptavidin coated...... magnetic nanoparticles attached to biotinylated LAMP amplicons. We demonstrate detection of sub-femtomolar Dengue DNA target concentrations in the ideal contamination-free lab environment within 20 min. The second detection approach is based on sequence-specific binding of functionalised magnetic...... claim detection of down to 100 fM of Dengue target after 20 min of LAMP with a contamination background....

  5. Elegant objects

    CERN Document Server

    Bugayenko, Yegor

    2017-01-01

    There are 23 practical recommendations for object-oriented programmers. Most of them are completely against everything you've read in other books. For example, static methods, NULL references, getters, setters, and mutable classes are called evil. Compound variable names, validators, private static literals, configurable objects, inheritance, annotations, MVC, dependency injection containers, reflection, ORM and even algorithms are our enemies.

  6. Objective lens

    Science.gov (United States)

    Olczak, Eugene G. (Inventor)

    2011-01-01

    An objective lens and a method for using same. The objective lens has a first end, a second end, and a plurality of optical elements. The optical elements are positioned between the first end and the second end and are at least substantially symmetric about a plane centered between the first end and the second end.

  7. Associations of Total and Domain-Specific Sedentary Time With Type 2 Diabetes in Taiwanese Older Adults

    Directory of Open Access Journals (Sweden)

    Ming-Chun Hsueh

    2016-07-01

    Full Text Available Background: The increasing prevalence of type 2 diabetes in older adults has become a public health concern. We investigated the associations of total and domain-specific sedentary time with risk of type 2 diabetes in older adults. Methods: The sample comprised 1046 older people (aged ≥65 years. Analyses were performed using crosssectional data collected via computer-assisted telephone-based interviews in 2014. Data on six self-reported domains of sedentary time (Measure of Older Adults’ Sedentary Time, type 2 diabetes status, and sociodemographic variables were included in the study. Binary logistic regression analysis was performed to calculate the adjusted odds ratios (ORs and 95% confidence intervals (CIs for total and individual sedentary behavior components and likelihood of type 2 diabetes. Results: A total of 17.5% of the participants reported type 2 diabetes. No significant associations were found between total sitting time and risk of type 2 diabetes, after controlling for confounding factors. After total sedentary behavior was stratified into six domains, only watching television for more than 2 hours per day was associated with higher odds of type 2 diabetes (OR 1.56; 95% CI, 1.10–2.21, but no significant associations were found between other domains of sedentary behavior (computer use, reading, socializing, transport, and hobbies and risk of type 2 diabetes. Conclusions: These findings suggest that, among domain-specific sedentary behavior, excessive television viewing might increase the risk of type 2 diabetes among older adults more than other forms of sedentary behavior.

  8. Objective Indicators of Physical Activity and Sedentary Time and Associations with Subjective Well-Being in Adults Aged 70 and Over

    Directory of Open Access Journals (Sweden)

    Janet Withall

    2014-01-01

    Full Text Available This study explored the associations of the volume and intensity of physical activity and the volume of sedentary time with subjective well-being in a diverse group of 228 older adults in the UK (111 female, mean age 78.2 years (SD 5.8. Physical activity (PA and sedentary behaviour were assessed by accelerometry deriving mean steps per day, mean moderate/vigorous PA minutes per hour (MVPA min·h−1 and minutes of sedentary time per hour (ST min·h−1. Lower limb function was assessed by the Short Physical Performance Battery. Subjective well-being was assessed using the SF-12 health status scale, the Ageing Well Profile and the Satisfaction with Life Scale. Linear regressions were used to investigate associations between the independent variables which included physical activity (steps and MVPA, sedentary time, participant characteristics (gender, age, BMI, education, number of medical conditions, and lower limb function and dependent variables which included mental and physical well-being. Steps, MVPA and lower limb function were independently and moderately positively associated with perceived physical well-being but relationships with mental well-being variables were weak. No significant associations between sedentary behaviours and well-being were observed. The association between objectively evaluated physical activity and function and subjective evaluations of physical well-being suggest that improving perceptions of physical health and function may provide an important target for physical activity programmes. This in turn may drive further activity participation.

  9. The curious influence of timing on the magical experience evoked by conjuring tricks involving false transfer: decay of amodal object permanence?

    Science.gov (United States)

    Beth, Tessa; Ekroll, Vebjørn

    2015-07-01

    In magic tricks involving false transfer, the conjurer typically creates the illusion of transferring a coin from one hand into the other, which is then closed into a fist, while in reality the coin is kept hidden in the first hand. The magical experience occurs when the closed fist of the second hand is opened and shown to be empty. According to professional magicians, the magical experience evoked by this kind of tricks becomes noticeably weaker when the time interval between the false transfer and the opening of the fist increases. This observation is surprising, given that neither the length of this interval nor any obvious factors associated with it can be expected to change the spectators' intellectual conviction regarding the true location of the coin. We performed a controlled psychological experiment and obtained results corroborating these informal observations. Increasing the temporal interval from 1 to 32 s led to an average reduction of the strength of the magical experience of 38%. We discuss potential explanations of this curious phenomenon in terms of object persistence, object files and temporal amodal completion.

  10. Verification of protein biomarker specificity for the identification of biological stains by quadrupole time-of-flight mass spectrometry.

    Science.gov (United States)

    Legg, Kevin M; Powell, Roger; Reisdorph, Nichole; Reisdorph, Rick; Danielson, Phillip B

    2017-03-01

    Advances in proteomics technology over the past decade offer forensic serologists a greatly improved opportunity to accurately characterize the tissue source from which a DNA profile has been developed. Such information can provide critical context to evidence and can help to prioritize downstream DNA analyses. Previous proteome studies compiled panels of "candidate biomarkers" specific to each of five body fluids (i.e., peripheral blood, vaginal/menstrual fluid, seminal fluid, urine, and saliva). Here, a multiplex quadrupole time-of-flight mass spectrometry assay has been developed in order to verify the tissue/body fluid specificity the 23 protein biomarkers that comprise these panels and the consistency with which they can be detected across a sample population of 50 humans. Single-source samples of these human body fluids were accurately identified by the detection of one or more high-specificity biomarkers. Recovery of body fluid samples from a variety of substrates did not impede accurate characterization and, of the potential inhibitors assayed, only chewing tobacco juice appeared to preclude the identification of a target body fluid. Using a series of 2-component mixtures of human body fluids, the multiplex assay accurately identified both components in a single-pass. Only in the case of saliva and peripheral blood did matrix effects appear to impede the detection of salivary proteins. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Optimal Rule-Based Power Management for Online, Real-Time Applications in HEVs with Multiple Sources and Objectives: A Review

    Directory of Open Access Journals (Sweden)

    Bedatri Moulik

    2015-08-01

    Full Text Available The field of hybrid vehicles has undergone intensive research and development, primarily due to the increasing concern of depleting resources and increasing pollution. In order to investigate further options to optimize the performance of hybrid vehicles with regards to different criteria, such as fuel economy, battery aging, etc., a detailed state-of-the-art review is presented in this contribution. Different power management and optimization techniques are discussed focusing on rule-based power management and multi-objective optimization techniques. The extent of rule-based power management and optimization in solving battery aging issues is investigated along with an implementation in real-time driving scenarios where no pre-defined drive cycle is followed. The goal of this paper is to illustrate the significance and applications of rule-based power management optimization based on previous contributions.

  12. Whole blood Nested PCR and Real-time PCR amplification of Talaromyces marneffei specific DNA for diagnosis.

    Science.gov (United States)

    Lu, Sha; Li, Xiqing; Calderone, Richard; Zhang, Jing; Ma, Jianchi; Cai, Wenying; Xi, Liyan

    2016-02-01

    Talaromyces marneffei is a dimorphic pathogenic fungus, which is a life-threatening invasive mycosis in the immunocompromised host. Prompt diagnosis of T. marneffei infection remains difficult although there has been progress in attempts to expedite the diagnosis of this infection. We previously demonstrated the value of nested polymerase chain reaction (PCR) to detect T. marneffei in paraffin embedded tissue samples with high sensitivity and specificity. In this study, this assay was used to detect the DNA of T. marneffei in whole blood samples. Real-time PCR assay was also evaluated to identify T. marneffei in the same samples. Twenty out of 30 whole blood samples (67%) collected from 23 patients were found positive by using the nested PCR assay, while 23/30 (77%) samples were found positive by using the real-time PCR assay. In order to express accurately the fungal loads, we used a normalized linearized plasmid as an internal control for real-time PCR. The assay results were correlated as the initial quantity (copies/μl) with fungal burden. These data indicate that combination of nested PCR and real-time PCR assay provides an attractive alternative for identification of T. marneffei DNA in whole blood samples of HIV-infected patients. © The Author 2015. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  13. Detection of all Chlamydophila and Chlamydia spp. of veterinary interest using species-specific real-time PCR assays.

    Science.gov (United States)

    Pantchev, Alexandra; Sting, Reinhard; Bauerfeind, Rolf; Tyczka, Judith; Sachse, Konrad

    2010-12-01

    The aim of the present study was to analyse the occurrence of chlamydiae in several mammalian host species. Clinical samples that previously tested positive in a Chlamydiaceae-specific real-time PCR were retested using six species-specific real-time PCR assays to identify the chlamydial species involved. Chlamydophila (Cp.) abortus was the agent most frequently found in cattle, sheep, horses, goats, and pigs. Detection in cattle of Cp. psittaci (11% of samples) and Chlamydia (C.) suis (9%), as well as Cp. psittaci in a goat sample was somewhat unexpected. DNA of two different chlamydiae was identified in 56 (12.7%) of 440 samples tested. Cp. felis was the predominant species found in cats, while in guinea pigs and rabbits only Cp. caviae was detected. Interestingly, the latter two pathogens were also identified in samples from dogs. The data show that mixed chlamydial infections are not rare and suggest an extended host range of individual species. Copyright © 2009 Elsevier Ltd. All rights reserved.

  14. Racial and Ethnic Variation in Time to Prostate Biopsy After an Elevated Screening Level of Serum Prostate-specific Antigen.

    Science.gov (United States)

    Reading, Stephanie R; Porter, Kimberly R; Hsu, Jin-Wen Y; Wallner, Lauren P; Loo, Ronald K; Jacobsen, Steven J

    2016-10-01

    To examine the racial and ethnic variation in time to prostate biopsy after an elevated screening level of serum prostate-specific antigen (PSA). Male members of the Kaiser Permanente of Southern California health plan, 45 years of age or older, with no history of prostate cancer or a prostate biopsy, and at least 1 elevated screening level of serum PSA between January 1, 1998 and December 31, 2007 were retrospectively identified (n = 59,506). All participants were passively followed via electronic health records until their time of prostate biopsy, death, membership disenrollment, or study conclusion (December 31, 2014), whichever was the initial event. Proportional hazard regression analyses were used to estimate the association between time from an elevated screening level of serum PSA to prostate biopsy, adjusting for age, benign prostatic hyperplasia, prostatitis, type 2 diabetes mellitus, hypertension, and Charlson Comorbidity Index score. Median time until biopsy was 0.6 years (214 days), with approximately 41% of participants receiving a prostate biopsy within the study period. Results from the fully adjusted analysis indicated that the non-Hispanic Asian or Pacific Islanders (hazard ratio: 1.10, 95% confidence interval: [1.04, 1.15]) and the non-Hispanic blacks (hazard ratio: 1.04, 95% confidence interval: [1.00, 1.08]) had a slightly shorter time to prostate biopsy after an elevated screening level of serum PSA compared to the non-Hispanic whites. These data suggest that, within an integrated healthcare organization, minimal differences exist between racial and ethnic subgroups in their time to prostate biopsy after an elevated screening level of serum PSA. Copyright © 2016. Published by Elsevier Inc.

  15. Patient-Specific Tailored Intervention Improves INR Time in Therapeutic Range and INR Variability in Heart Failure Patients.

    Science.gov (United States)

    Gotsman, Israel; Ezra, Orly; Hirsh Raccah, Bruria; Admon, Dan; Lotan, Chaim; Dekeyser Ganz, Freda

    2017-08-01

    Many patients with heart failure need anticoagulants, including warfarin. Good control is particularly challenging in heart failure patients, with range, thereby increasing the risk of complications. This study aimed to evaluate the effect of a patient-specific tailored intervention on anticoagulation control in patients with heart failure. Patients with heart failure taking warfarin therapy (n = 145) were randomized to either standard care or a 1-time intervention assessing potential risk factors for lability of INR, in which they received patient-specific instructions. Time in therapeutic range (TTR) using Rosendaal's linear model was assessed 3 months before and after the intervention. The patient-tailored intervention significantly increased anticoagulation control. The median TTR levels before intervention were suboptimal in the interventional and control groups (53% vs 45%, P = .14). After intervention the median TTR increased significantly in the interventional group compared with the control group (80% [interquartile range, 62%-93%] vs 44% [29%-61%], P <.0001). The intervention resulted in a significant improvement in the interventional group before versus after intervention (53% vs 80%, P <.0001) but not in the control group (45% vs 44%, P = .95). The percentage of patients with a TTR ≥60%, considered therapeutic, was substantially higher in the interventional group: 79% versus 25% (P <.0001). The INR variability (standard deviation of each patient's INR measurements) decreased significantly in the interventional group, from 0.53 to 0.32 (P <.0001) after intervention but not in the control group. Patient-specific tailored intervention significantly improves anticoagulation therapy in patients with heart failure. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Extended objects

    International Nuclear Information System (INIS)

    Creutz, M.

    1976-01-01

    After some disconnected comments on the MIT bag and string models for extended hadrons, I review current understanding of extended objects in classical conventional relativistic field theories and their quantum mechanical interpretation

  17. Trusted Objects

    International Nuclear Information System (INIS)

    CAMPBELL, PHILIP L.; PIERSON, LYNDON G.; WITZKE, EDWARD L.

    1999-01-01

    In the world of computers a trusted object is a collection of possibly-sensitive data and programs that can be allowed to reside and execute on a computer, even on an adversary's machine. Beyond the scope of one computer we believe that network-based agents in high-consequence and highly reliable applications will depend on this approach, and that the basis for such objects is what we call ''faithful execution.''

  18. Conceptual Modeling of Events as Information Objects and Change Agents

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    as a totality of an information object and a change agent. When an event is modeled as an information object it is comparable to an entity that exists only at a specific point in time. It has attributes and can be used for querying and specification of constraints. When an event is modeled as a change agent...... it is comparable to an executable transaction schema. Finally, we briefly compare our approach to object-oriented approaches based on encapsulated objects....

  19. Objects in Motion

    Science.gov (United States)

    Damonte, Kathleen

    2004-01-01

    One thing scientists study is how objects move. A famous scientist named Sir Isaac Newton (1642-1727) spent a lot of time observing objects in motion and came up with three laws that describe how things move. This explanation only deals with the first of his three laws of motion. Newton's First Law of Motion says that moving objects will continue…

  20. Object-Based Paddy Rice Mapping Using HJ-1A/B Data and Temporal Features Extracted from Time Series MODIS NDVI Data.

    Science.gov (United States)

    Singha, Mrinal; Wu, Bingfang; Zhang, Miao

    2016-12-22

    Accurate and timely mapping of paddy rice is vital for food security and environmental sustainability. This study evaluates the utility of temporal features extracted from coarse resolution data for object-based paddy rice classification of fine resolution data. The coarse resolution vegetation index data is first fused with the fine resolution data to generate the time series fine resolution data. Temporal features are extracted from the fused data and added with the multi-spectral data to improve the classification accuracy. Temporal features provided the crop growth information, while multi-spectral data provided the pattern variation of paddy rice. The achieved overall classification accuracy and kappa coefficient were 84.37% and 0.68, respectively. The results indicate that the use of temporal features improved the overall classification accuracy of a single-date multi-spectral image by 18.75% from 65.62% to 84.37%. The minimum sensitivity (MS) of the paddy rice classification has also been improved. The comparison showed that the mapped paddy area was analogous to the agricultural statistics at the district level. This work also highlighted the importance of feature selection to achieve higher classification accuracies. These results demonstrate the potential of the combined use of temporal and spectral features for accurate paddy rice classification.

  1. Visual attentional engagement deficits in children with specific language impairment and their role in real-time language processing.

    Science.gov (United States)

    Dispaldro, Marco; Leonard, Laurence B; Corradi, Nicola; Ruffino, Milena; Bronte, Tiziana; Facoetti, Andrea

    2013-09-01

    In order to become a proficient user of language, infants must detect temporal cues embedded within the noisy acoustic spectra of ongoing speech by efficient attentional engagement. According to the neuro-constructivist approach, a multi-sensory dysfunction of attentional engagement - hampering the temporal sampling of stimuli - might be responsible for language deficits typically shown in children with Specific Language Impairment (SLI). In the present study, the efficiency of visual attentional engagement was investigated in 22 children with SLI and 22 typically developing (TD) children by measuring attentional masking (AM). AM refers to impaired identification of the first of two sequentially presented masked objects (O1 and O2) in which the O1-O2 interval was manipulated. Lexical and grammatical comprehension abilities were also tested in both groups. Children with SLI showed a sluggish engagement of temporal attention, and individual differences in AM accounted for a significant percentage of unique variance in grammatical performance. Our results suggest that an attentional engagement deficit - probably linked to a dysfunction of the right fronto-parietal attentional network - might be a contributing factor in these children's language impairments. Copyright © 2012 Elsevier Ltd. All rights reserved.

  2. Real-time monitoring of specific oxygen uptake rates of embryonic stem cells in a microfluidic cell culture device.

    Science.gov (United States)

    Super, Alexandre; Jaccard, Nicolas; Cardoso Marques, Marco Paulo; Macown, Rhys Jarred; Griffin, Lewis Donald; Veraitch, Farlan Singh; Szita, Nicolas

    2016-09-01

    Oxygen plays a key role in stem cell biology as a signaling molecule and as an indicator of cell energy metabolism. Quantification of cellular oxygen kinetics, i.e. the determination of specific oxygen uptake rates (sOURs), is routinely used to understand metabolic shifts. However current methods to determine sOUR in adherent cell cultures rely on cell sampling, which impacts on cellular phenotype. We present real-time monitoring of cell growth from phase contrast microscopy images, and of respiration using optical sensors for dissolved oxygen. Time-course data for bulk and peri-cellular oxygen concentrations obtained for Chinese hamster ovary (CHO) and mouse embryonic stem cell (mESCs) cultures successfully demonstrated this non-invasive and label-free approach. Additionally, we confirmed non-invasive detection of cellular responses to rapidly changing culture conditions by exposing the cells to mitochondrial inhibiting and uncoupling agents. For the CHO and mESCs, sOUR values between 8 and 60 amol cell(-1) s(-1) , and 5 and 35 amol cell(-1) s(-1) were obtained, respectively. These values compare favorably with literature data. The capability to monitor oxygen tensions, cell growth, and sOUR, of adherent stem cell cultures, non-invasively and in real time, will be of significant benefit for future studies in stem cell biology and stem cell-based therapies. © 2016 The Authors. Biotechnology Journal published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Objective measurement of minimal fat in normal skeletal muscles of healthy children using T2 relaxation time mapping (T2 maps) and MR spectroscopy.

    Science.gov (United States)

    Kim, Hee Kyung; Serai, Suraj; Merrow, Arnold C; Wang, Lily; Horn, Paul S; Laor, Tal

    2014-02-01

    Various skeletal muscle diseases result in fatty infiltration, making it important to develop noninvasive biomarkers to objectively measure muscular fat. We compared T2 relaxation time mapping (T2 maps) and magnetic resonance spectroscopy (MRS) with physical characteristics previously correlated with intramuscular fat to validate T2 maps and MRS as objective measures of skeletal muscle fat. We evaluated gluteus maximus muscles in 30 healthy boys (ages 5-19 years) at 3 T with T1-weighted images, T2-W images with fat saturation, T2 maps with and without fat saturation, and MR spectroscopy. We calculated body surface area (BSA), body mass index (BMI) and BMI percentile (BMI %). We performed fat and inflammation grading on T1-W imaging and fat-saturated T2-W imaging, respectively. Mean T2 values from T2 maps with fat saturation were subtracted from T2 maps without fat saturation to determine T2 fat values. We obtained lipid-to-water ratios by MR spectroscopy. Pearson correlation was used to assess relationships between BSA, BMI, BMI %, T2 fat values, and lipid-to-water ratios for each boy. Twenty-four boys completed all exams; 21 showed minimal and 3 showed no fatty infiltration. None showed muscle inflammation. There was correlation between BSA, BMI, and BMI %, and T2 fat values (P values and lipid-to-water ratios (P skeletal muscles, even in microscopic amounts, and validate each other. Both techniques might enable detection of minimal pathological fatty infiltration in children with skeletal muscle disorders.

  4. Electronic Excitations in Solution: The Interplay between State Specific Approaches and a Time-Dependent Density Functional Theory Description.

    Science.gov (United States)

    Guido, Ciro A; Jacquemin, Denis; Adamo, Carlo; Mennucci, Benedetta

    2015-12-08

    We critically analyze the performances of continuum solvation models when coupled to time-dependent density functional theory (TD-DFT) to predict solvent effects on both absorption and emission energies of chromophores in solution. Different polarization schemes of the polarizable continuum model (PCM), such as linear response (LR) and three different state specific (SS) approaches, are considered and compared. We show the necessity of introducing a SS model in cases where large electron density rearrangements are involved in the excitations, such as charge-transfer transitions in both twisted and quadrupolar compounds, and underline the very delicate interplay between the selected polarization method and the chosen exchange-correlation functional. This interplay originates in the different descriptions of the transition and ground/excited state multipolar moments by the different functionals. As a result, the choice of both the DFT functional and the solvent polarization scheme has to be consistent with the nature of the studied electronic excitation.

  5. Reasoning about Function Objects

    Science.gov (United States)

    Nordio, Martin; Calcagno, Cristiano; Meyer, Bertrand; Müller, Peter; Tschannen, Julian

    Modern object-oriented languages support higher-order implementations through function objects such as delegates in C#, agents in Eiffel, or closures in Scala. Function objects bring a new level of abstraction to the object-oriented programming model, and require a comparable extension to specification and verification techniques. We introduce a verification methodology that extends function objects with auxiliary side-effect free (pure) methods to model logical artifacts: preconditions, postconditions and modifies clauses. These pure methods can be used to specify client code abstractly, that is, independently from specific instantiations of the function objects. To demonstrate the feasibility of our approach, we have implemented an automatic prover, which verifies several non-trivial examples.

  6. Time-varying causal network of the Korean financial system based on firm-specific risk premiums

    Science.gov (United States)

    Song, Jae Wook; Ko, Bonggyun; Cho, Poongjin; Chang, Woojin

    2016-09-01

    The aim of this paper is to investigate the Korean financial system based on time-varying causal network. We discover many stylized facts by utilizing the firm-specific risk premiums for measuring the causality direction from a firm to firm. At first, we discover that the interconnectedness of causal network is affected by the outbreak of financial events; the co-movement of firm-specific risk premium is strengthened after each positive event, and vice versa. Secondly, we find that the major sector of the Korean financial system is the Depositories, and the financial reform in June-2011 achieves its purpose by weakening the power of risk-spillovers of Broker-Dealers. Thirdly, we identify that the causal network is a small-world network with scale-free topology where the power-law exponents of out-Degree and negative event are more significant than those of in-Degree and positive event. Lastly, we discuss that the current aspects of causal network are closely related to the long-term future scenario of the KOSPI Composite index where the direction and stability are significantly affected by the power of risk-spillovers and the power-law exponents of degree distributions, respectively.

  7. One-year retention of general and sequence-specific skills in a probabilistic, serial reaction time task.

    Science.gov (United States)

    Romano, Jennifer C; Howard, James H; Howard, Darlene V

    2010-05-01

    Procedural skills such as riding a bicycle and playing a musical instrument play a central role in daily life. Such skills are learned gradually and are retained throughout life. The present study investigated 1-year retention of procedural skill in a version of the widely used serial reaction time task (SRTT) in young and older motor-skill experts and older controls in two experiments. The young experts were college-age piano and action video-game players, and the older experts were piano players. Previous studies have reported sequence-specific skill retention in the SRTT as long as 2 weeks but not at 1 year. Results indicated that both young and older experts and older non-experts revealed sequence-specific skill retention after 1 year with some evidence that general motor skill was retained as well. These findings are consistent with theoretical accounts of procedural skill learning such as the procedural reinstatement theory as well as with previous studies of retention of other motor skills.

  8. Development and validation of a real-time PCR assay for specific and sensitive detection of canid herpesvirus 1.

    Science.gov (United States)

    Decaro, Nicola; Amorisco, Francesca; Desario, Costantina; Lorusso, Eleonora; Camero, Michele; Bellacicco, Anna Lucia; Sciarretta, Rossana; Lucente, Maria Stella; Martella, Vito; Buonavoglia, Canio

    2010-10-01

    A TaqMan-based real-time PCR assay targeting the glycoprotein B-encoding gene was developed for diagnosis of canid herpesvirus 1 (CHV-1) infection. The established assay was highly specific, since no cross-reactions were observed with other canine DNA viruses, including canine parvovirus type 2, canine minute virus, or canine adenovirus types 1 and 2. The detection limit was 10(1) and 1.20 x 10(1) DNA copies per 10 microl(-1) of template for standard DNA and a CHV-1-positive kidney sample, respectively: about 1-log higher than a gel-based PCR assay targeting the thymidine kinase gene. The assay was also reproducible, as shown by satisfactory low intra-assay and inter-assay coefficients of variation. CHV-1 isolates of different geographical origins were recognised by the TaqMan assay. Tissues and clinical samples collected from three pups which died of CHV-1 neonatal infection were also tested, displaying a wide distribution of CHV-l DNA in their organs. Unlike other CHV-1-specific diagnostic methods, this quantitative assay permits simultaneous detection and quantitation of CHV-1 DNA in a wide range of canine tissues and body fluids, thus providing a useful tool for confirmation of a clinical diagnosis, for the study of viral pathogenesis and for evaluation of the efficacy of vaccines and antiviral drugs. Copyright (c) 2010 Elsevier B.V. All rights reserved.

  9. Per Object statistical analysis

    DEFF Research Database (Denmark)

    2008-01-01

    of a specific class in turn, and uses as pair of PPO stages to derive the statistics and then assign them to the objects' Object Variables. It may be that this could all be done in some other, simply way, but several other ways that were tried did not succeed. The procedure ouptut has been tested against...

  10. Probing specific molecular processes and intermediates by time-resolved Fourier transform infrared spectroscopy: application to the bacteriorhodopsin photocycle.

    Science.gov (United States)

    Lórenz-Fonfría, Víctor A; Kandori, Hideki; Padrós, Esteve

    2011-06-23

    We present a general approach for probing the kinetics of specific molecular processes in proteins by time-resolved Fourier transform infrared (IR) spectroscopy. Using bacteriorhodopsin (bR) as a model we demonstrate that by appropriately monitoring some selected IR bands it is possible obtaining the kinetics of the most important events occurring in the photocycle, namely changes in the chromophore and the protein backbone conformation, and changes in the protonation state of the key residues implicated in the proton transfers. Besides confirming widely accepted views of the bR photocycle, our analysis also sheds light into some disputed issues: the degree of retinal torsion in the L intermediate to respect the ground state; the possibility of a proton transfer from Asp85 to Asp212; the relationship between the protonation/deprotonation of Asp85 and the proton release complex; and the timing of the protein backbone dynamics. By providing a direct way to estimate the kinetics of photocycle intermediates the present approach opens new prospects for a robust quantitative kinetic analysis of the bR photocycle, which could also benefit the study of other proteins involved in photosynthesis, in phototaxis, or in respiratory chains.

  11. Cognitive assessment of mice strains heterozygous for cell-adhesion genes reveals strain-specific alterations in timing.

    Science.gov (United States)

    Gallistel, C R; Tucci, Valter; Nolan, Patrick M; Schachner, Melitta; Jakovcevski, Igor; Kheifets, Aaron; Barboza, Luendro

    2014-03-05

    We used a fully automated system for the behavioural measurement of physiologically meaningful properties of basic mechanisms of cognition to test two strains of heterozygous mutant mice, Bfc (batface) and L1, and their wild-type littermate controls. Both of the target genes are involved in the establishment and maintenance of synapses. We find that the Bfc heterozygotes show reduced precision in their representation of interval duration, whereas the L1 heterozygotes show increased precision. These effects are functionally specific, because many other measures made on the same mice are unaffected, namely: the accuracy of matching temporal investment ratios to income ratios in a matching protocol, the rate of instrumental and classical conditioning, the latency to initiate a cued instrumental response, the trials on task and the impulsivity in a switch paradigm, the accuracy with which mice adjust timed switches to changes in the temporal constraints, the days to acquisition, and mean onset time and onset variability in the circadian anticipation of food availability.

  12. Sika deer (Cervus nippon)-specific real-time PCR method to detect fraudulent labelling of meat and meat products.

    Science.gov (United States)

    Kaltenbrunner, Maria; Hochegger, Rupert; Cichna-Markl, Margit

    2018-05-08

    Since game meat is more valuable and expensive than meat from domesticated animal species it is a potential target for adulteration. Analytical methods must allow the identification and quantification of meat species to be applicable for the detection of fraudulent labelling. We developed a real-time PCR assay for the authentication of sika deer (Cervus nippon) and products thereof. The primer/probe system amplifies a 71 bp fragment of the kappa-casein precursor gene. Since the target sequence contained only one sika deer-specific base, we introduced a deliberate base mismatch in the forward primer. The real-time PCR assay did not show cross-reactivity with 19 animal and 49 plant species tested. Low cross-reactivity was observed with red deer, fallow deer, reindeer and moose. However, with a ΔCt value of ≥11.79 between sika deer and the cross-reacting species, cross-reactivity will not affect the accuracy of the method. LOD and LOQ, determined by analysing serial dilutions of a DNA extract containing 1% (w/w) sika deer DNA in pig DNA, were 0.3% and 0.5%, respectively. The accuracy was evaluated by analysing DNA mixtures and DNA isolates from meat extract mixtures and meat mixtures. In general, recoveries were in the range from 70 to 130%.

  13. No specific time window distinguishes between community-, healthcare-, and hospital-acquired bacteremia, but they are prognostically robust

    DEFF Research Database (Denmark)

    Gradel, Kim Oren; Nielsen, Stig Lønberg; Pedersen, Court

    2014-01-01

    ), and hospital acquisition influenced the results of prognostic models. Design. Population-based cohort study. Setting. Hospitals in 3 areas of Denmark (2.3 million inhabitants) during 2000-2011. Methods. We computed graphs depicting proportions of males, absence of comorbidity, microorganisms, and 30-day......], 1.23-1.37) to 1.99 (95% CI, 1.48-2.67) for HCA and from 1.36 (95% CI, 1.24-1.50) to 2.53 (95% CI, 2.01-3.20) for hospital acquisition compared with community acquisition. Area under the ROC curve changed marginally from 0.684 (95% CI, 0.679-0.689) to 0.700 (95% CI, 0.695-0.705). Conclusions. No time......) curve for 30-day mortality, adjusting for sex, age, comorbidity, and microorganisms. Results. For 56,606 bacteremic episodes, no sharp transitions were detected on a specific day after admission. Among the 8 combined time windows, ORs for 30-day mortality varied from 1.30 (95% confidence interval [CI...

  14. Solving a bi-objective mathematical model for location-routing problem with time windows in multi-echelon reverse logistics using metaheuristic procedure

    Science.gov (United States)

    Ghezavati, V. R.; Beigi, M.

    2016-12-01

    During the last decade, the stringent pressures from environmental and social requirements have spurred an interest in designing a reverse logistics (RL) network. The success of a logistics system may depend on the decisions of the facilities locations and vehicle routings. The location-routing problem (LRP) simultaneously locates the facilities and designs the travel routes for vehicles among established facilities and existing demand points. In this paper, the location-routing problem with time window (LRPTW) and homogeneous fleet type and designing a multi-echelon, and capacitated reverse logistics network, are considered which may arise in many real-life situations in logistics management. Our proposed RL network consists of hybrid collection/inspection centers, recovery centers and disposal centers. Here, we present a new bi-objective mathematical programming (BOMP) for LRPTW in reverse logistic. Since this type of problem is NP-hard, the non-dominated sorting genetic algorithm II (NSGA-II) is proposed to obtain the Pareto frontier for the given problem. Several numerical examples are presented to illustrate the effectiveness of the proposed model and algorithm. Also, the present work is an effort to effectively implement the ɛ-constraint method in GAMS software for producing the Pareto-optimal solutions in a BOMP. The results of the proposed algorithm have been compared with the ɛ-constraint method. The computational results show that the ɛ-constraint method is able to solve small-size instances to optimality within reasonable computing times, and for medium-to-large-sized problems, the proposed NSGA-II works better than the ɛ-constraint.

  15. Objective-guided image annotation.

    Science.gov (United States)

    Mao, Qi; Tsang, Ivor Wai-Hung; Gao, Shenghua

    2013-04-01

    Automatic image annotation, which is usually formulated as a multi-label classification problem, is one of the major tools used to enhance the semantic understanding of web images. Many multimedia applications (e.g., tag-based image retrieval) can greatly benefit from image annotation. However, the insufficient performance of image annotation methods prevents these applications from being practical. On the other hand, specific measures are usually designed to evaluate how well one annotation method performs for a specific objective or application, but most image annotation methods do not consider optimization of these measures, so that they are inevitably trapped into suboptimal performance of these objective-specific measures. To address this issue, we first summarize a variety of objective-guided performance measures under a unified representation. Our analysis reveals that macro-averaging measures are very sensitive to infrequent keywords, and hamming measure is easily affected by skewed distributions. We then propose a unified multi-label learning framework, which directly optimizes a variety of objective-specific measures of multi-label learning tasks. Specifically, we first present a multilayer hierarchical structure of learning hypotheses for multi-label problems based on which a variety of loss functions with respect to objective-guided measures are defined. And then, we formulate these loss functions as relaxed surrogate functions and optimize them by structural SVMs. According to the analysis of various measures and the high time complexity of optimizing micro-averaging measures, in this paper, we focus on example-based measures that are tailor-made for image annotation tasks but are seldom explored in the literature. Experiments show consistency with the formal analysis on two widely used multi-label datasets, and demonstrate the superior performance of our proposed method over state-of-the-art baseline methods in terms of example-based measures on four

  16. Testing object Interactions

    NARCIS (Netherlands)

    Grüner, Andreas

    2010-01-01

    In this thesis we provide a unit testing approach for multi-purposes object-oriented programming languages in the style of Java and C#. Our approach includes the definition of a test specification language which results from extending the programming language with new designated specification

  17. Amaro-autonomous real-time detection of moving maritime objects: introducing a flight experiment for an on-board ship detection system

    Science.gov (United States)

    Schwenk, Kurt; Willburger, Katharina; Pless, Sebastian

    2017-10-01

    Motivated by politics and economy, the monitoring of the world wide ship traffic is a field of high topicality. To detect illegal activities like piracy, illegal fishery, ocean dumping and refugee transportation is of great value. The analysis of satellite images on the ground delivers a great contribution to situation awareness. However, for many applications the up-to-dateness of the data is crucial. With ground based processing, the time between image acquisition and delivery of the data to the end user is in the range of several hours. The highest influence to the duration of ground based processing is the delay caused by the transmission of the large amount of image data from the satellite to the processing centre on the ground. One expensive solution to this issue is the usage of data relay satellites systems like EDRS. Another approach is to analyse the image data directly on-board of the satellite. Since the product data (e.g. ship position, heading, velocity, characteristics) is very small compared to the input image data, real-time connections provided by satellite telecommunication services like Iridium or Orbcomm can be used to send small packets of information directly to the end user without significant delay. The AMARO (Autonomous real-time detection of moving maritime objects) project at DLR is a feasibility study of an on-board ship detection system involving a real-time low bandwidth communication. The operation of a prototype on-board ship detection system will be demonstrated on an airborne platform. In this article, the scope, aim and design of a flight experiment for an on-board ship detection system scheduled for mid of 2018 is presented. First, the scope and the constraints of the experiment are explained in detail. The main goal is to demonstrate the operability of an automatic ship detection system on board of an airplane. For data acquisition the optical high resolution DLR MACS-MARE camera (VIS/NIR) is used. The system will be able to

  18. Estimating Time-Varying PCB Exposures Using Person-Specific Predictions to Supplement Measured Values: A Comparison of Observed and Predicted Values in Two Cohorts of Norwegian Women

    Science.gov (United States)

    Nøst, Therese Haugdahl; Breivik, Knut; Wania, Frank; Rylander, Charlotta; Odland, Jon Øyvind; Sandanger, Torkjel Manning

    2015-01-01

    Background Studies on the health effects of polychlorinated biphenyls (PCBs) call for an understanding of past and present human exposure. Time-resolved mechanistic models may supplement information on concentrations in individuals obtained from measurements and/or statistical approaches if they can be shown to reproduce empirical data. Objectives Here, we evaluated the capability of one such mechanistic model to reproduce measured PCB concentrations in individual Norwegian women. We also assessed individual life-course concentrations. Methods Concentrations of four PCB congeners in pregnant (n = 310, sampled in 2007–2009) and postmenopausal (n = 244, 2005) women were compared with person-specific predictions obtained using CoZMoMAN, an emission-based environmental fate and human food-chain bioaccumulation model. Person-specific predictions were also made using statistical regression models including dietary and lifestyle variables and concentrations. Results CoZMoMAN accurately reproduced medians and ranges of measured concentrations in the two study groups. Furthermore, rank correlations between measurements and predictions from both CoZMoMAN and regression analyses were strong (Spearman’s r > 0.67). Precision in quartile assignments from predictions was strong overall as evaluated by weighted Cohen’s kappa (> 0.6). Simulations indicated large inter-individual differences in concentrations experienced in the past. Conclusions The mechanistic model reproduced all measurements of PCB concentrations within a factor of 10, and subject ranking and quartile assignments were overall largely consistent, although they were weak within each study group. Contamination histories for individuals predicted by CoZMoMAN revealed variation between study subjects, particularly in the timing of peak concentrations. Mechanistic models can provide individual PCB exposure metrics that could serve as valuable supplements to measurements. Citation Nøst TH, Breivik K, Wania F

  19. The Utility of General and School-Specific Personality Traits and an Examination of Their Relationship over Time

    Science.gov (United States)

    Eschleman, Kevin J.; Burns, Gary

    2012-01-01

    A university student sample was used to compare school-specific (i.e., personality at school) and general personality (i.e., personality across all life domains) over eight weeks. School-specific and general personality incrementally predicted change in school-specific criteria (i.e., school satisfaction and school citizenship behaviors). Less…

  20. Real-time surgery simulation of intracranial aneurysm clipping with patient-specific geometries and haptic feedback

    Science.gov (United States)

    Fenz, Wolfgang; Dirnberger, Johannes

    2015-03-01

    Providing suitable training for aspiring neurosurgeons is becoming more and more problematic. The increasing popularity of the endovascular treatment of intracranial aneurysms leads to a lack of simple surgical situations for clipping operations, leaving mainly the complex cases, which present even experienced surgeons with a challenge. To alleviate this situation, we have developed a training simulator with haptic interaction allowing trainees to practice virtual clipping surgeries on real patient-specific vessel geometries. By using specialized finite element (FEM) algorithms (fast finite element method, matrix condensation) combined with GPU acceleration, we can achieve the necessary frame rate for smooth real-time interaction with the detailed models needed for a realistic simulation of the vessel wall deformation caused by the clamping with surgical clips. Vessel wall geometries for typical training scenarios were obtained from 3D-reconstructed medical image data, while for the instruments (clipping forceps, various types of clips, suction tubes) we use models provided by manufacturer Aesculap AG. Collisions between vessel and instruments have to be continuously detected and transformed into corresponding boundary conditions and feedback forces, calculated using a contact plane method. After a training, the achieved result can be assessed based on various criteria, including a simulation of the residual blood flow into the aneurysm. Rigid models of the surgical access and surrounding brain tissue, plus coupling a real forceps to the haptic input device further increase the realism of the simulation.

  1. Tissue-specific Calibration of Real-time PCR Facilitates Absolute Quantification of Plasmid DNA in Biodistribution Studies

    Directory of Open Access Journals (Sweden)

    Joan K Ho

    2016-01-01

    Full Text Available Analysis of the tissue distribution of plasmid DNA after administration of nonviral gene delivery systems is best accomplished using quantitative real-time polymerase chain reaction (qPCR, although published strategies do not allow determination of the absolute mass of plasmid delivered to different tissues. Generally, data is expressed as the mass of plasmid relative to the mass of genomic DNA (gDNA in the sample. This strategy is adequate for comparisons of efficiency of delivery to a single site but it does not allow direct comparison of delivery to multiple tissues, as the mass of gDNA extracted per unit mass of each tissue is different. We show here that by constructing qPCR standard curves for each tissue it is possible to determine the dose of intact plasmid remaining in each tissue, which is a more useful parameter when comparing the fates of different formulations of DNA. We exemplify the use of this tissue-specific qPCR method by comparing the delivery of naked DNA, cationic DNA complexes, and neutral PEGylated DNA complexes after intramuscular injection. Generally, larger masses of intact plasmid were present 24 hours after injection of DNA complexes, and neutral complexes resulted in delivery of a larger mass of intact plasmid to the spleen.

  2. Age-specific vibrissae growth rates: a tool for determining the timing of ecologically important events in Steller sea lions

    Science.gov (United States)

    Rea, L.D.; Christ, A.M.; Hayden, A.B.; Stegall, V.K.; Farley, S.D.; Stricker, Craig A.; Mellish, J.E.; Maniscalco, John M.; Waite, J.N.; Burkanov, V.N.; Pitcher, K.W.

    2015-01-01

    Steller sea lions (SSL; Eumetopias jubatus) grow their vibrissae continually, providing a multiyear record suitable for ecological and physiological studies based on stable isotopes. An accurate age-specific vibrissae growth rate is essential for registering a chronology along the length of the record, and for interpreting the timing of ecologically important events. We utilized four methods to estimate the growth rate of vibrissae in fetal, rookery pup, young-of-the-year (YOY), yearling, subadult, and adult SSL. The majority of vibrissae were collected from SSL live-captured in Alaska and Russia between 2000 and 2013 (n = 1,115), however, vibrissae were also collected from six adult SSL found dead on haul-outs and rookeries during field excursions to increase the sample size of this underrepresented age group. Growth rates of vibrissae were generally slower in adult (0.44 ± 0.15 cm/mo) and subadult (0.61 ± 0.10 cm/mo) SSL than in YOY (0.87 ± 0.28 cm/mo) and fetal (0.73 ± 0.05 cm/mo) animals, but there was high individual variability in these growth rates within each age group. Some variability in vibrissae growth rates was attributed to the somatic growth rate of YOY sea lions between capture events (P = 0.014, r2 = 0.206, n = 29).

  3. Site-Specific Measurement of Water Dynamics in the Substrate Pocket of Ketosteroid Isomerase Using Time-Resolved Vibrational Spectroscopy

    Science.gov (United States)

    Jha, Santosh Kumar; Ji, Minbiao; Gaffney, Kelly J.; Boxer, Steven G.

    2012-01-01

    Little is known about the reorganization capacity of water molecules at the active sites of enzymes and how this couples to the catalytic reaction. Here, we study the dynamics of water molecules at the active site of a highly proficient enzyme, Δ5-3-ketosteroid isomerase (KSI), during a light-activated mimic of its catalytic cycle. Photo-excitation of a nitrile containing photo-acid, coumarin183 (C183), mimics the change in charge density that occurs at the active site of KSI during the first step of the catalytic reaction. The nitrile of C183 is exposed to water when bound to the KSI active site, and we used time-resolved vibrational spectroscopy as a site-specific probe to study the solvation dynamics of water molecules in the vicinity of the nitrile. We observed that water molecules at the active site of KSI are highly rigid, during the light-activated catalytic cycle, compared to the solvation dynamics observed in bulk water. Based upon this result we hypothesize that rigid water dipoles at the active site might help in the maintenance of the pre-organized electrostatic environment required for efficient catalysis. The results also demonstrate the utility of nitrile probes in measuring the dynamics of local (H-bonded) water molecules in contrast to the commonly used fluorescence methods which measure the average behavior of primary and subsequent spheres of solvation. PMID:22931297

  4. Quantitative Time-Resolved Fluorescence Imaging of Androgen Receptor and Prostate-Specific Antigen in Prostate Tissue Sections.

    Science.gov (United States)

    Krzyzanowska, Agnieszka; Lippolis, Giuseppe; Helczynski, Leszek; Anand, Aseem; Peltola, Mari; Pettersson, Kim; Lilja, Hans; Bjartell, Anders

    2016-05-01

    Androgen receptor (AR) and prostate-specific antigen (PSA) are expressed in the prostate and are involved in prostate cancer (PCa). The aim of this study was to develop reliable protocols for reproducible quantification of AR and PSA in benign and malignant prostate tissue using time-resolved fluorescence (TRF) imaging techniques. AR and PSA were detected with TRF in tissue microarrays from 91 PCa patients. p63/ alpha-methylacyl-CoA racemase (AMACR) staining on consecutive sections was used to categorize tissue areas as benign or cancerous. Automated image analysis was used to quantify staining intensity. AR intensity was significantly higher in AMACR+ and lower in AMACR- cancer areas as compared with benign epithelium. The PSA intensity was significantly lower in cancer areas, particularly in AMACR- glands. The AR/PSA ratio varied significantly in the AMACR+ tumor cells as compared with benign glands. There was a trend of more rapid disease progression in patients with higher AR/PSA ratios in the AMACR- areas. This study demonstrates the feasibility of developing reproducible protocols for TRF imaging and automated image analysis to study the expression of AR and PSA in benign and malignant prostate. It also highlighted the differences in AR and PSA protein expression within AMACR- and AMACR+ cancer regions. © 2016 The Histochemical Society.

  5. Clinical evaluation of a Mucorales-specific real-time PCR assay in tissue and serum samples.

    Science.gov (United States)

    Springer, Jan; Lackner, Michaela; Ensinger, Christian; Risslegger, Brigitte; Morton, Charles Oliver; Nachbaur, David; Lass-Flörl, Cornelia; Einsele, Hermann; Heinz, Werner J; Loeffler, Juergen

    2016-12-01

    Molecular diagnostic assays can accelerate the diagnosis of fungal infections and subsequently improve patient outcomes. In particular, the detection of infections due to Mucorales is still challenging for laboratories and physicians. The aim of this study was to evaluate a probe-based Mucorales-specific real-time PCR assay (Muc18S) using tissue and serum samples from patients suffering from invasive mucormycosis (IMM). This assay can detect a broad range of clinically relevant Mucorales species and can be used to complement existing diagnostic tests or to screen high-risk patients. An advantage of the Muc18S assay is that it exclusively detects Mucorales species allowing the diagnosis of Mucorales DNA without sequencing within a few hours. In paraffin-embedded tissue samples this PCR-based method allowed rapid identification of Mucorales in comparison with standard methods and showed 91 % sensitivity in the IMM tissue samples. We also evaluated serum samples, an easily accessible material, from patients at risk from IMM. Mucorales DNA was detected in all patients with probable/proven IMM (100 %) and in 29 % of the possible cases. Detection of IMM in serum could enable an earlier diagnosis (up to 21 days) than current methods including tissue samples, which were gained mainly post-mortem. A screening strategy for high-risk patients, which would enable targeted treatment to improve patient outcomes, is therefore possible.

  6. A silicon-based electrochemical sensor for highly sensitive, specific, label-free and real-time DNA detection

    International Nuclear Information System (INIS)

    Guo, Yuanyuan; Su, Shao; Wei, Xinpan; Zhong, Yiling; Su, Yuanyuan; He, Yao; Huang, Qing; Fan, Chunhai

    2013-01-01

    We herein present a new kind of silicon-based electrochemical sensor using a gold nanoparticles-decorated silicon wafer (AuNPs@Si) as a high-performance electrode, which is facilely prepared via in situ AuNPs growth on a silicon wafer. Particularly significantly, the resultant electrochemical sensor is efficacious for label-free DNA detection with high sensitivity due to the unique merits of the prepared silicon-based electrode. Typically, DNA at remarkably low concentrations (1–10 fM) could be readily detected without requiring additional signal-amplification procedures, which is better than or comparable to the lowest DNA concentration ever detected via well-studied signal-amplification-assisted electrochemical sensors. Moreover, the silicon-based sensor features high specificity, allowing unambiguous discrimination of single-based mismatches. We further show that real-time DNA assembly is readily monitored via recording the intensity changes of current signals due to the robust thermal stability of the silicon-based electrode. The unprecedented advantages of the silicon-based electrochemical sensor would offer new opportunities for myriad sensing applications. (paper)

  7. Rapid diagnostic tests as a source of DNA for Plasmodium species-specific real-time PCR

    Directory of Open Access Journals (Sweden)

    Van Esbroeck Marjan

    2011-03-01

    Full Text Available Abstract Background This study describes the use of malaria rapid diagnostic tests (RDTs as a source of DNA for Plasmodium species-specific real-time PCR. Methods First, the best method to recover DNA from RDTs was investigated and then the applicability of this DNA extraction method was assessed on 12 different RDT brands. Finally, two RDT brands (OptiMAL Rapid Malaria Test and SDFK60 malaria Ag Plasmodium falciparum/Pan test were comprehensively evaluated on a panel of clinical samples submitted for routine malaria diagnosis at ITM. DNA amplification was done with the 18S rRNA real-time PCR targeting the four Plasmodium species. Results of PCR on RDT were compared to those obtained by PCR on whole blood samples. Results Best results were obtained by isolating DNA from the proximal part of the nitrocellulose component of the RDT strip with a simple DNA elution method. The PCR on RDT showed a detection limit of 0.02 asexual parasites/μl, which was identical to the same PCR on whole blood. For all 12 RDT brands tested, DNA was detected except for one brand when a low parasite density sample was applied. In RDTs with a plastic seal covering the nitrocellulose strip, DNA extraction was hampered. PCR analysis on clinical RDT samples demonstrated correct identification for single species infections for all RDT samples with asexual parasites of P. falciparum (n = 60, Plasmodium vivax (n = 10, Plasmodium ovale (n = 10 and Plasmodium malariae (n = 10. Samples with only gametocytes were detected in all OptiMAL and in 10 of the 11 SDFK60 tests. None of the negative samples (n = 20 gave a signal by PCR on RDT. With PCR on RDT, higher Ct-values were observed than with PCR on whole blood, with a mean difference of 2.68 for OptiMAL and 3.53 for SDFK60. Mixed infections were correctly identified with PCR on RDT in 4/5 OptiMAL tests and 2/5 SDFK60 tests. Conclusions RDTs are a reliable source of DNA for Plasmodium real-time PCR. This study demonstrates the

  8. Objectively Measured Sedentary Time and Cardiovascular Risk Factor Control in US Hispanics/Latinos With Diabetes Mellitus: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

    Science.gov (United States)

    Wang, Xueyin; Strizich, Garrett; Hua, Simin; Sotres-Alvarez, Daniela; Buelna, Christina; Gallo, Linda C; Gellman, Marc D; Mossavar-Rahmani, Yasmin; O'Brien, Matthew J; Stoutenberg, Mark; Wang, Tao; Avilés-Santa, M Larissa; Kaplan, Robert C; Qi, Qibin

    2017-05-25

    Cardiovascular disease (CVD) risk factor control is a cornerstone of diabetes mellitus management. Little is known about relationships of objectively measured sedentary time and physical activity with major CVD risk factor control in individuals with diabetes mellitus. We examined associations of objectively measured sedentary time and moderate-to-vigorous physical activity with reaching major CVD risk factor control goals among US Hispanic/Latino adults with diabetes mellitus. This cross-sectional analysis included 1699 participants with diabetes mellitus from the Hispanic Community Health Study/Study of Latinos (2008-2011). Logistic regression models were used to estimate the odds ratios (ORs) of meeting the following 5 major CVD risk factor control goals: hemoglobin A 1c 40/50 mg/dL for men/women. After adjustment for covariates including moderate-to-vigorous physical activity, less sedentary time was associated with increased odds of reaching hemoglobin A 1c (OR=1.76 [95% CI: 1.10, 2.82]) and triglyceride control goals (OR=2.16 [1.36, 3.46]), and reaching ≥3 CVD risk factor control goals (OR=2.08 [1.34, 3.23]) (all ORs for comparisons of extreme tertiles of sedentary time). Moderate-to-vigorous physical activity was not associated with reaching any CVD risk factor control goals. Substituting 60-min/day of sedentary time with light-intensity physical activity was associated with increased odds of reaching hemoglobin A 1c (OR=1.18 [1.04, 1.35]), high-density lipoprotein cholesterol (OR=1.17 [1.04, 1.32]), and triglyceride (OR=1.20 [1.05, 1.36]) control goals. Among US Hispanic/Latino adults with diabetes mellitus, less sedentary time, but not moderate-to-vigorous physical activity, was associated with improved CVD risk factor control, specifically in reaching hemoglobin A 1c and triglyceride control goals. © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

  9. Piles of objects

    KAUST Repository

    Hsu, Shu-Wei; Keyser, John

    2010-01-01

    We present a method for directly modeling piles of objects in multi-body simulations. Piles of objects represent some of the more interesting, but also most time-consuming portion of simulation. We propose a method for reducing computation in many

  10. Functional Time Series Models to Estimate Future Age-Specific Breast Cancer Incidence Rates for Women in Karachi, Pakistan

    Institute of Scientific and Technical Information of China (English)

    Farah Yasmeen[1; Sidra Zaheer[2

    2014-01-01

    Background: Breast cancer is the most common female cancer in Pakistan. The incidence of breast cancer in Pakistan is about 2.5 times higher than that in the neighboring countries India and Iran. In Karachi, the most populated city of Pakistan, the age-standardized rate of breast cancer was 69.1 per 100,000 women during 1998-2002, which is the highest recorded rate in Asia. The carcinoma of breast in Pakistan is an enormous public health concern. In this study, we examined the recent trends of breast cancer incidence rates among the women in Karachi. Methods: We obtained the secondary data of breast cancer incidence from various hospitals. They included Jinnah Hospital, KIRAN (Karachi Institute of Radiotherapy and Nuclear Medicine), and Civil hospital, where the data were available for the years 2004-2011. A total of 5331 new cases of female breast cancer were registered during this period. We analyzed the data in 5-year age groups 15-19, 20-24, 25-29, 30-34, 35-39, 40-44, 45-49, 50-54, 55-59, 60-64, 65-69, 70-74, 75+. Nonparametric smoothing were used to obtained age-specific incidence curves, and then the curves are decomposed using principal components analysis to fit FTS (functional time series) model. We then used exponential smoothing statspace models to estimate the forecasts of incidence curve and construct prediction intervals. Results: The breast cancer incidence rates in Karachi increased with age for all available years. The rates increased monotonically and are relatively sharp with the age from 15 years to 50 years and then they show variability after the age of 50 years. 10-year forecasts for the female breast cancer incidence rates in Karachi show that the future rates are expected to remain stable for the age-groups 15-50 years, but they will increase for the females of 50-years and over. Hence in future, the newly diagnosed breast cancer cases in the older women in Karachi are expected to increase. Conclusion: Prediction of age

  11. The Effect of Stabilization Exercises on Objective Outcome Measures in Patients with Chronic Non-Specific Low Back Pain: A Systematic Review with Particular Emphasis On Randomized Controlled Clinical Trial

    Directory of Open Access Journals (Sweden)

    Fatemeh Ehsani

    2013-07-01

    Full Text Available Objective: Low back pain (LBP is one of the most common and costly health problems. Changes in muscle activity and recruitment of lumbar deep muscles which are responsible for lumbar spine stability have been reported in patients with LBP. Different exercise programs are used in the treatment of such patients to improve spinal stability. The purpose of this study was to systematically review the effect of stabilization exercises on objective outcome measures in patients with non-specific chronic LBP in previous randomized controlled trials. Materials & Methods: A literature search for the period of 2000-2012 was performed, using MEDLINE, PubMed, Google scholar, Science Direct, OVID and CINAHL databases. Low back pain, stabilization exercise, motor control exercise, segmental stabilization, transverse abdominis muscle, multifidus muscle, electromyography, ultrasound, ultrasonography, and randomized controlled trial were used as keywords. Muscle recruitment, postural balance control, muscle endurance, muscle size and lumbar range of motion were studied as objective outcome measures.  Results: In total, of 158 articles, 13 articles were selected according to the inclusion criteria of the study. There was a wide variation among studies in terms of methodology, main outcome measures, sample size, procedure, etc. The results demonstrated that stabilization exercise was more effective than other interventions on activity pattern of deep muscles, postural balance control, muscle endurance and range of motion, while it was not significantly different with other interventions on deep muscle size.  Conclusion: It seems that stabilization exercise has considerable effect on activity pattern of deep muscles, postural control, muscle endurance and range of motion and can be considered as an effective intervention in the treatment of patients with non-specific chronic LBP

  12. Vascular aging processes accelerate following a cubic kinetic: pulse wave velocity as an objective counterpart that time, as we age, goes by faster

    Directory of Open Access Journals (Sweden)

    Gabutti L

    2018-02-01

    Full Text Available Luca Gabutti, Rosaria Del Giorno Department of Internal Medicine and Nephrology, Bellinzona Regional Hospital, Bellinzona, SwitzerlandArterial stiffness is a marker of vascular aging and is considered to be the most reliable parameter expressing, like an integral in mathematics, the cumulative consequences, on the vascular wall, of degenerative and adaptive changes occurring throughout life.1 The efficiency of the reparative processes, the cardiovascular risk factors (CVRF, and early life and genetic determinants, all play a relevant role.1 Among CVRF, the acceleration in arterial stiffness progression related to age is mainly influenced by hypertension.1 A pathological acceleration translates into the concept of early vascular aging, a concept that can be quantified calculating the gap between the subject’s chronological (estimated on the basis of the epidemiological data obtained in the normal population and effective vascular age.2 Data of subpopulations without active risk factors for accelerated vascular aging can be found mainly in three large epidemiological studies, performed respectively in Portugal,3 Argentina,4 and seven different European countries (Belgium, Czech Republic, France, Greece, Italy, the Netherlands, and UK gathered in a collaborative investigation.5 Those doing this secondary analysis were aware of the limitation related to the use of cross-sectional data to extrapolate longitudinal changes, and their aims were combining the abovementioned epidemiological data concerning the normal population to calculate with the highest possible accuracy 1 the age-related increase in acceleration of the pulse wave velocity (PWV and to estimate both 2 the age-specific relative amount of time equivalent to that necessary to progress 1 year in vascular age at 20, and 3 the cumulative relative age calculated in year equivalents. 

  13. Development, optimization, and single laboratory validation of an event-specific real-time PCR method for the detection and quantification of Golden Rice 2 using a novel taxon-specific assay.

    Science.gov (United States)

    Jacchia, Sara; Nardini, Elena; Savini, Christian; Petrillo, Mauro; Angers-Loustau, Alexandre; Shim, Jung-Hyun; Trijatmiko, Kurniawan; Kreysa, Joachim; Mazzara, Marco

    2015-02-18

    In this study, we developed, optimized, and in-house validated a real-time PCR method for the event-specific detection and quantification of Golden Rice 2, a genetically modified rice with provitamin A in the grain. We optimized and evaluated the performance of the taxon (targeting rice Phospholipase D α2 gene)- and event (targeting the 3' insert-to-plant DNA junction)-specific assays that compose the method as independent modules, using haploid genome equivalents as unit of measurement. We verified the specificity of the two real-time PCR assays and determined their dynamic range, limit of quantification, limit of detection, and robustness. We also confirmed that the taxon-specific DNA sequence is present in single copy in the rice genome and verified its stability of amplification across 132 rice varieties. A relative quantification experiment evidenced the correct performance of the two assays when used in combination.

  14. Persistent effects of pre-weaning in piglets on composition of fecal microbiota are diet-, genus-, and time-specific

    Science.gov (United States)

    The effects of diet on gut microbiota composition in the pre-weaning period have been characterized, but it is unknown whether differences in composition are sustained after weaning. The objective of this study was to determine if post-natal diet-induced differences in microbiota persist after weani...

  15. Development and validation of Burkholderia pseudomallei-specific real-time PCR assays for clinical, environmental or forensic detection applications.

    Directory of Open Access Journals (Sweden)

    Erin P Price

    Full Text Available The bacterium Burkholderia pseudomallei causes melioidosis, a rare but serious illness that can be fatal if untreated or misdiagnosed. Species-specific PCR assays provide a technically simple method for differentiating B. pseudomallei from near-neighbor species. However, substantial genetic diversity and high levels of recombination within this species reduce the likelihood that molecular signatures will differentiate all B. pseudomallei from other Burkholderiaceae. Currently available molecular assays for B. pseudomallei detection lack rigorous validation across large in silico datasets and isolate collections to test for specificity, and none have been subjected to stringent quality control criteria (accuracy, precision, selectivity, limit of quantitation (LoQ, limit of detection (LoD, linearity, ruggedness and robustness to determine their suitability for environmental, clinical or forensic investigations. In this study, we developed two novel B. pseudomallei specific assays, 122018 and 266152, using a dual-probe approach to differentiate B. pseudomallei from B. thailandensis, B. oklahomensis and B. thailandensis-like species; other species failed to amplify. Species specificity was validated across a large DNA panel (>2,300 samples comprising Burkholderia spp. and non-Burkholderia bacterial and fungal species of clinical and environmental relevance. Comparison of assay specificity to two previously published B. pseudomallei-specific assays, BurkDiff and TTS1, demonstrated comparable performance of all assays, providing between 99.7 and 100% specificity against our isolate panel. Last, we subjected 122018 and 266152 to rigorous quality control analyses, thus providing quantitative limits of assay performance. Using B. pseudomallei as a model, our study provides a framework for comprehensive quantitative validation of molecular assays and provides additional, highly validated B. pseudomallei assays for the scientific research community.

  16. Safety objectives and basic design for surface centres for long-term storage of solid radioactive waste with short or medium half-life and low or medium specific activity

    International Nuclear Information System (INIS)

    1984-06-01

    RFS or Regles Fondamentales de Surete (Basic Safety Rules) applicable to certain types of nuclear facilities lay down requirements with which compliance, for the type of facilities and within the scope of application covered by the RFS, is considered to be equivalent to compliance with technical French regulatory practice. The object of the RFS is to take advantage of standardization in the field of safety, while allowing for technical progress in that field. They are designed to enable the operating utility and contractors to know the rules pertaining to various subjects which are considered to be acceptable by the Service Central de Surete des Installations Nucleaires, or the SCSIN (Central Department for the Safety of Nuclear Facilities). These RFS should make safety analysis easier and lead to better understanding between experts and individuals concerned with the problems of nuclear safety. The SCSIN reserves the right to modify, when considered necessary, any RFS and specify, if need be, the terms under which a modification is deemed retroactive. The role of this RFS is to define the safety objectives and the basic design philosophy for surface centres for long-term storage of packages of radioactive waste with short or medium half-life and with low or medium specific activity

  17. The Effect of Time on Word Learning: An Examination of Decay of the Memory Trace and Vocal Rehearsal in Children with and without Specific Language Impairment

    Science.gov (United States)

    Alt, Mary; Spaulding, Tammie

    2011-01-01

    Purpose: The purpose of this study was to measure the effect of time to response in a fast-mapping word learning task for children with specific language impairment (SLI) and children with typically developing language skills (TD). Manipulating time to response allows us to examine decay of the memory trace, the use of vocal rehearsal, and their…

  18. Object permanence in lemurs.

    Science.gov (United States)

    Deppe, Anja M; Wright, Patricia C; Szelistowski, William A

    2009-03-01

    Object permanence, the ability to mentally represent objects that have disappeared from view, should be advantageous to animals in their interaction with the natural world. The objective of this study was to examine whether lemurs possess object permanence. Thirteen adult subjects representing four species of diurnal lemur (Eulemur fulvus rufus, Eulemur mongoz, Lemur catta and Hapalemur griseus) were presented with seven standard Piagetian visible and invisible object displacement tests, plus one single visible test where the subject had to wait predetermined times before allowed to search, and two invisible tests where each hiding place was made visually unique. In all visible tests lemurs were able to find an object that had been in clear view before being hidden. However, when lemurs were not allowed to search for up to 25-s, performance declined with increasing time-delay. Subjects did not outperform chance on any invisible displacements regardless of whether hiding places were visually uniform or unique, therefore the upper limit of object permanence observed was Stage 5b. Lemur species in this study eat stationary foods and are not subject to stalking predators, thus Stage 5 object permanence is probably sufficient to solve most problems encountered in the wild.

  19. Gamifying Video Object Segmentation.

    Science.gov (United States)

    Spampinato, Concetto; Palazzo, Simone; Giordano, Daniela

    2017-10-01

    Video object segmentation can be considered as one of the most challenging computer vision problems. Indeed, so far, no existing solution is able to effectively deal with the peculiarities of real-world videos, especially in cases of articulated motion and object occlusions; limitations that appear more evident when we compare the performance of automated methods with the human one. However, manually segmenting objects in videos is largely impractical as it requires a lot of time and concentration. To address this problem, in this paper we propose an interactive video object segmentation method, which exploits, on one hand, the capability of humans to identify correctly objects in visual scenes, and on the other hand, the collective human brainpower to solve challenging and large-scale tasks. In particular, our method relies on a game with a purpose to collect human inputs on object locations, followed by an accurate segmentation phase achieved by optimizing an energy function encoding spatial and temporal constraints between object regions as well as human-provided location priors. Performance analysis carried out on complex video benchmarks, and exploiting data provided by over 60 users, demonstrated that our method shows a better trade-off between annotation times and segmentation accuracy than interactive video annotation and automated video object segmentation approaches.

  20. Maternal Employment in Norway A parity-specific analysis of the return to full-time and part-time work after birth

    OpenAIRE

    Marit Rønsen

    1995-01-01

    This paper analyzes the (re)entry of Norwegian mothers into full-time and part-time employment following the first and second birth. Based on theories of job search and human capital depreciation and appreciation a semi-parametric hazard model is estimated, expressing the entry rate as a function of a woman's full wage (the market wage plus the present value of reductions in future earnings due to a career break) and her reservation wage. As predicted, a higher market wage and higher accumula...