Measuring upconversion nanoparticles photoluminescence lifetime with FastFLIM and phasor plots

Science.gov (United States)

Sun, Yuansheng; Lee, Hsien-Ming; Qiu, Hailin; Liao, Shih-Chu Jeff; Coskun, Ulas; Barbieri, Beniamino

2018-02-01

Photon upconversion is a nonlinear process in which the sequential of absorption of two or more photons leads to the anti-stoke emission. Different than the conventional multiphoton excitation process, upconversion can be efficiently performed at low excitation densities. Recent developments in lanthanide-doped upconversion nanoparticles (UCNPs) have led to a diversity of applications, including detecting and sensing of biomolecules, imaging of live cells, tissues and animals, cancer diagnostic and therapy, etc. Measuring the upconversion lifetime provides a new dimension of its imaging and opens a new window for its applications. Due to the long metastable intermediate excited state, UCNP typically has a long excited state lifetime ranging from sub-microseconds to milliseconds. Here, we present a novel development using the FastFLIM technique to measure UCNP lifetime by laser scanning confocal microscopy. FastFLIM is capable of measuring lifetime from 100 ps to 100 ms and features the high data collection efficiency (up to 140-million counts per second). Other than the traditional nonlinear least-square fitting analysis, the raw data acquired by FastFLIM can be directly processed by the model-free phasor plots approach for instant and unbiased lifetime results, providing the ideal routine for the UCNP photoluminescence lifetime microscopy imaging.

Probing energy metabolism and microviscosity in cancer using FLIM

Science.gov (United States)

Shirmanova, Marina V.; Lukina, Maria M.; Shimolina, Lyubov'E.; Kuimova, Marina K.; Dudenkova, Varvara V.; Shcheslavskiy, Vladislav I.; Zagaynova, Elena V.

2017-07-01

Fluorescence lifetime imaging microscopy (FLIM) is a promising non-invasive highly sensitive technique for probing multiple physiological and physicochemical parameters in living cells and tissues. The present study is focused on the investigation of bioenergetics and microscopic viscosity of cultured cancer cells and animal tumors using FLIM during natural growth and chemotherapy. Fluorescence lifetime measurements of the metabolic cofactor NAD(P)H revealed a decrease of the relative amplitude of free NAD(P)H after cisplatin treatment, indicating a change towards a more oxidative metabolic state. Microviscosity mapping performed with the use of fluorescent molecular rotor BODIPY-2 showed a pronounced increase in the plasma membrane viscosity in cancer cells exposed to cisplatin. Although biochemical mechanisms underlying the metabolic and viscosity alterations during chemotherapy have yet to be clarified, our data suggest that the cisplatin-induced changes in cellular metabolism and membrane viscosity play a role in the cytotoxicity of the drug. The results of the study contribute to an understanding of mechanisms of cisplatin action and will be useful for development new approach for assessing response to a therapy.

A novel clinical multimodal multiphoton tomograph for AF, SHG, CARS imaging, and FLIM

Science.gov (United States)

Weinigel, Martin; Breunig, Hans Georg; König, Karsten

2014-02-01

We report on a flexible nonlinear medical tomograph with multiple miniaturized detectors for simultaneous acquisition of two-photon autofluorescence (AF), second harmonic generation (SHG) and coherent anti-Stokes Raman scattering (CARS) images. The simultaneous visualization of the distribution of endogenous fluorophores NAD(P)H, melanin and elastin, SHG-active collagen and as well as non-fluorescent lipids within human skin in vivo is possible. Furthermore, fluorescence lifetime images (FLIM) can be generated using time-correlated single photon counting.

Fluorescence lifetime imaging using light emitting diodes

Energy Technology Data Exchange (ETDEWEB)

Kennedy, Gordon T; Munro, Ian; Poher, Vincent; French, Paul M W; Neil, Mark A A [Blackett Laboratory, Imperial College London, South Kensington Campus, London SW7 2AZ (United Kingdom); Elson, Daniel S [Institute of Biomedical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ (United Kingdom); Hares, Jonathan D [Kentech Instruments Ltd, Unit 9, Hall Farm Workshops, South Moreton, Didcot, Oxfordshire, OX11 9AG (United Kingdom)], E-mail: gordon.kennedy@imperial.ac.uk

2008-05-07

We demonstrate flexible use of low cost, high-power light emitting diodes as illumination sources for fluorescence lifetime imaging (FLIM). Both time-domain and frequency-domain techniques have been implemented at wavelengths spanning the range 450-640 nm. Additionally, we demonstrate optically sectioned fluorescence lifetime imaging by combining structured illumination with frequency-domain FLIM.

Modelling of the influence of the 'Flimserstein' tunnel on the Lag Tiert karstic spring in Flims; Modellierung des Einflusses des Flimserstein-Tunnels auf die Karstquelle des Lag Tiert (Flims, GR)

Energy Technology Data Exchange (ETDEWEB)

Jeannin, P.-Y.; Haeuselmann, P. [Schweizerisches Institut fuer Spelaeologie und Karstkunde SISKA, La Chaux-de-Fonds (Switzerland); Wildberger, A. [Dr. von Moos AG, Geotechnisches Buero, Zuerich (Switzerland)

2007-12-15

This report describes the modelling of the influence of the 'Flimserstein' tunnel on the Lag Tiert karstic spring in Flims, Switzerland. When the tunnel, that provides a by-pass for the mountain village of Flims, was built, a karstic system was broached. As a result, several springs dried up and others had their capacity reduced. Also, the quantity of water available for a local hydropower station was reduced. The report describes how the situation as far as the underground watercourses are concerned was modelled and how exactly the tunnel construction changed the water-quantities at the various springs. The results of the study are presented and discussed and recommendations are made concerning the modelling of such karstic systems.

Towards early detection of age-related macular degeneration with tetracyclines and FLIM

Science.gov (United States)

Szmacinski, Henryk; Hegde, Kavita; Zeng, Hui-Hui; Eslami, Katayoun; Puche, Adam; Lakowicz, Joseph R.; Lengyel, Imre; Thompson, Richard B.

2018-02-01

Recently, we discovered microscopic spherules of hydroxyapatite (HAP) in aged human sub-retinal pigment epithelial (sub-RPE) deposits in the retinas of aged humans (PMID: 25605911), and developed evidence that the spherules may act to nucleate the growth of sub-RPE deposits such as drusen. Drusen are clinical hallmarks of age-related macular degeneration (AMD). We found that tetracycline-family antibiotics, long known to stain HAP in teeth and bones, also stained the HAP spherules, but in general the HAP-bound fluorescence excitation and emission spectra overlapped with the well-known autofluorescence of the RPE overlying drusen, making them difficult to resolve. However, we also found that certain tetracyclines exhibited substantial increases in fluorescence lifetime upon binding to HAP, and moreover these lifetimes were substantially greater than those previously observed (Dysli, et al., 2014) for autofluorescence in the human retina in vivo. Thus we were able to image the HAP spherules by fluorescence lifetime imaging microscopy (FLIM) in cadaveric retinas of aged humans. These findings suggest that FLIM imaging of tetracycline binding to HAP could become a diagnostic tool for the development and progression of AMD.

Optimizing FRET-FLIM Labeling Conditions to Detect Nuclear Protein Interactions at Native Expression Levels in Living Arabidopsis Roots

KAUST Repository

Long, Yuchen

2018-05-15

Protein complex formation has been extensively studied using Förster resonance energy transfer (FRET) measured by Fluorescence Lifetime Imaging Microscopy (FLIM). However, implementing this technology to detect protein interactions in living multicellular organism at single-cell resolution and under native condition is still difficult to achieve. Here we describe the optimization of the labeling conditions to detect FRET-FLIM in living plants. This study exemplifies optimization procedure involving the identification of the optimal position for the labels either at the N or C terminal region and the selection of the bright and suitable, fluorescent proteins as donor and acceptor labels for the FRET study. With an effective optimization strategy, we were able to detect the interaction between the stem cell regulators SHORT-ROOT and SCARECROW at endogenous expression levels in the root pole of living Arabidopsis embryos and developing lateral roots by FRET-FLIM. Using this approach we show that the spatial profile of interaction between two transcription factors can be highly modulated in reoccurring and structurally resembling organs, thus providing new information on the dynamic redistribution of nuclear protein complex configurations in different developmental stages. In principle, our optimization procedure for transcription factor complexes is applicable to any biological system.

Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging

OpenAIRE

Wang, Haolu; Liang, Xiaowen; Mohammed, Yousuf H.; Thomas, James A.; Bridle, Kim R.; Thorling, Camilla A.; Grice, Jeffrey E.; Xu, Zhi Ping; Liu, Xin; Crawford, Darrell H. G.; Roberts, Michael S.

2015-01-01

Conventional histology with light microscopy is essential in the diagnosis of most liver diseases. Recently, a concept of real-time histology with optical biopsy has been advocated. In this study, live mice livers (normal, with fibrosis, steatosis, hepatocellular carcinoma and ischemia-reperfusion injury) were imaged by MPM-FLIM for stain-free real-time histology. The acquired MPM-FLIM images were compared with conventional histological images. MPM-FLIM imaged subsurface cellular and subcellu...

Imaging molecular interactions in cells by dynamic and static fluorescence anisotropy (rFLIM and emFRET)

NARCIS (Netherlands)

Lidke, D.S.; Nagy, P.; Barisas, B.G.; Heintzmann, R.; Post, Janine Nicole; Lidke, K.A.; Clayton, A.H.A.; Arndt-jovin, D.J.; Jovin, T.M.

2003-01-01

We report the implementation and exploitation of fluorescence polarization measurements, in the form of anisotropy fluorescence lifetime imaging microscopy (rFLIM) and energy migration Förster resonance energy transfer (emFRET) modalities, for wide-field, confocal laser-scanning microscopy and flow

Modulated electron-multiplied fluorescence lifetime imaging microscope: all-solid-state camera for fluorescence lifetime imaging.

Science.gov (United States)

Zhao, Qiaole; Schelen, Ben; Schouten, Raymond; van den Oever, Rein; Leenen, René; van Kuijk, Harry; Peters, Inge; Polderdijk, Frank; Bosiers, Jan; Raspe, Marcel; Jalink, Kees; Geert Sander de Jong, Jan; van Geest, Bert; Stoop, Karel; Young, Ian Ted

2012-12-01

We have built an all-solid-state camera that is directly modulated at the pixel level for frequency-domain fluorescence lifetime imaging microscopy (FLIM) measurements. This novel camera eliminates the need for an image intensifier through the use of an application-specific charge coupled device design in a frequency-domain FLIM system. The first stage of evaluation for the camera has been carried out. Camera characteristics such as noise distribution, dark current influence, camera gain, sampling density, sensitivity, linearity of photometric response, and optical transfer function have been studied through experiments. We are able to do lifetime measurement using our modulated, electron-multiplied fluorescence lifetime imaging microscope (MEM-FLIM) camera for various objects, e.g., fluorescein solution, fixed green fluorescent protein (GFP) cells, and GFP-actin stained live cells. A detailed comparison of a conventional microchannel plate (MCP)-based FLIM system and the MEM-FLIM system is presented. The MEM-FLIM camera shows higher resolution and a better image quality. The MEM-FLIM camera provides a new opportunity for performing frequency-domain FLIM.

Optimizing FRET-FLIM Labeling Conditions to Detect Nuclear Protein Interactions at Native Expression Levels in Living Arabidopsis Roots

KAUST Repository

Long, Yuchen; Stahl, Yvonne; Weidtkamp-Peters, Stefanie; Smet, Wouter; Du, Yujuan; Gadella, Theodorus W. J.; Goedhart, Joachim; Scheres, Ben; Blilou, Ikram

2018-01-01

Protein complex formation has been extensively studied using Förster resonance energy transfer (FRET) measured by Fluorescence Lifetime Imaging Microscopy (FLIM). However, implementing this technology to detect protein interactions in living

Increasing the collection efficiency of time-correlated single-photon counting with single-photon avalanche diodes using immersion lenses.

Science.gov (United States)

Pichette, Charles; Giudice, Andrea; Thibault, Simon; Bérubé-Lauzière, Yves

2016-11-20

Single-photon avalanche diodes (SPADs) achieving high timing resolution (≈20-50  ps) developed for time-correlated single-photon counting (TCSPC) generally have very small photosensitive areas (25-100 μm in diameter). This limits the achievable photon counting rate and signal-to-noise ratio and may lead to long counting times. This is detrimental in applications requiring several measurements, such as fluorescence lifetime imaging (FLIM) microscopy, which requires scanning, and time-domain diffuse optical tomography (TD-DOT). We show in this work that the use of an immersion lens directly affixed onto the photosensitive area of the SPAD helps alleviate this problem by allowing more light to be concentrated onto the detector. Following careful optical design and simulations, our experimental results show that it is actually possible to achieve the predicted theoretical increase in the photon counting rate (we achieve a factor of ≈4 here). This work is of high relevance in high timing resolution TCSPC with small photosensitive area detectors and should find widespread interest in FLIM and TD-DOT with SPADs.

Ato protein interactions in yeast plasma membrane revealed by fluorescence lifetime imaging (FLIM)

Czech Academy of Sciences Publication Activity Database

Strachotová, Dita; Holoubek, A.; Kučerová, Helena; Benda, Aleš; Humpolíčková, Jana; Váchová, Libuše; Palková, Z.

2012-01-01

Roč. 1818, č. 9 (2012), s. 2126-2134 ISSN 0005-2736 R&D Projects: GA ČR GA204/08/0718; GA MŠk(CZ) LC06063; GA MŠk(CZ) LC531 Institutional research plan: CEZ:AV0Z40400503 Institutional support: RVO:61388971 Keywords : Ammonium exporters Ato1p * Ato2p and Ato3p * FLIM-photobleaching technique Subject RIV: CE - Biochemistry Impact factor: 3.389, year: 2012

An automated wide-field time-gated optically sectioning fluorescence lifetime imaging multiwell plate reader for high-content analysis of protein-protein interactions

Science.gov (United States)

Alibhai, Dominic; Kumar, Sunil; Kelly, Douglas; Warren, Sean; Alexandrov, Yuriy; Munro, Ian; McGinty, James; Talbot, Clifford; Murray, Edward J.; Stuhmeier, Frank; Neil, Mark A. A.; Dunsby, Chris; French, Paul M. W.

2011-03-01

We describe an optically-sectioned FLIM multiwell plate reader that combines Nipkow microscopy with wide-field time-gated FLIM, and its application to high content analysis of FRET. The system acquires sectioned FLIM images in fluorescent protein. It has been applied to study the formation of immature HIV virus like particles (VLPs) in live cells by monitoring Gag-Gag protein interactions using FLIM FRET of HIV-1 Gag transfected with CFP or YFP. VLP formation results in FRET between closely packed Gag proteins, as confirmed by our FLIM analysis that includes automatic image segmentation.

Ultra-fast HPM detectors improve NAD(P)H FLIM

Science.gov (United States)

Becker, Wolfgang; Wetzker, Cornelia; Benda, Aleš

2018-02-01

Metabolic imaging by NAD(P)H FLIM requires the decay functions in the individual pixels to be resolved into the decay components of bound and unbound NAD(P)H. Metabolic information is contained in the lifetime and relative amplitudes of the components. The separation of the decay components and the accuracy of the amplitudes and lifetimes improves substantially by using ultra-fast HPM-100-06 and HPM-100-07 hybrid detectors. The IRF width in combination with the Becker & Hickl SPC-150N and SPC-150NX TCSPC modules is less than 20 ps. An IRF this fast does not interfere with the fluorescence decay. The usual deconvolution process in the data analysis then virtually becomes a simple curve fitting, and the parameters of the NAD(P)H decay components are obtained at unprecedented accuracy.

Heliborne time domain electromagnetic system

International Nuclear Information System (INIS)

Bhattacharya, S.

2009-01-01

Atomic Minerals Directorate (AMD), are using heliborne and ground time domain electromagnetic (TDEM) system for the exploration of deep seated unconformity type uranium deposits. Uranium has been explored in various parts of the world like Athabasca basin using time domain electromagnetic system. AMD has identified some areas in India where such deposits are available. Apart from uranium exploration, the TDEM systems are used for the exploration of deep seated minerals like diamonds. Bhabha Atomic Research Centre (BARC) is involved in the indigenous design of the heliborne time domain system since this system is useful for DAE and also it has a scope of wide application. In this paper we discuss about the principle of time domain electromagnetic systems, their capabilities and the development and problems of such system for various other mineral exploration. (author)

Conversion of Dielectric Data from the Time Domain to the Frequency Domain

Directory of Open Access Journals (Sweden)

Vladimir Durman

2005-01-01

Full Text Available Polarisation and conduction processes in dielectric systems can be identified by the time domain or the frequency domain measurements. If the systems is a linear one, the results of the time domain measurements can be transformed into the frequency domain, and vice versa. Commonly, the time domain data of the absorption conductivity are transformed into the frequency domain data of the dielectric susceptibility. In practice, the relaxation are mainly evaluated by the frequency domain data. In the time domain, the absorption current measurement were prefered up to now. Recent methods are based on the recovery voltage measurements. In this paper a new method of the recovery data conversion from the time the frequency domain is proposed. The method is based on the analysis of the recovery voltage transient based on the Maxwell equation for the current density in a dielectric. Unlike the previous published solutions, the Laplace fransform was used to derive a formula suitable for practical purposes. the proposed procedure allows also calculating of the insulation resistance and separating the polarisation and conduction losses.

Two-photon autofluorescence/FLIM/SHG endoscopy to study the oral cavity and wound healing in humans (Conference Presentation)

Science.gov (United States)

König, Karsten

2016-03-01

Monitoring the oral cavity noninvasively with superior 3D resolution is realized by clinical multiphoton tomography and high NA two-photon endoscopy without the need of additional contrast agents. The technology behind this investigation is based on nonlinear optical contrast of the multiphoton tomograph MPTflex®. Furthermore, the miniaturized GRIN endoscope was used to realize more accessibility for more demanding wound conditions in skin. The MPTflex® distinguishes autofluorescence (AF) signals from second harmonic generation (SHG) signals simultaneously. Fluorescence lifetime imaging (FLIM) based on time correlated single photon counting (TCSPC) technology offers additional information on the functional level of the intratissue fluorophores, their binding status, and the contribution of SHG signals in chronic wounds.

Refractive index sensing using Fluorescence Lifetime Imaging (FLIM)

International Nuclear Information System (INIS)

Jones, Carolyn; Suhling, Klaus

2006-01-01

The fluorescence lifetime is a function of the refractive index of the fluorophore's environment, for example in the case of the biologically important green fluorescent protein (GFP). In order to address the question whether this effect can be exploited to image the local environment of specific proteins in cell biology, we need to determine the distance over which the fluorophore's lifetime is sensitive to the refractive index. To this end, we employ Fluorescence Lifetime Imaging (FLIM) of fluorescein in NaOH buffer at an interface. This approach allows us to map the fluorescence lifetime as a function of distance from a buffer/air and buffer/oil interface. Preliminary data show that the fluorescence lifetime of fluorescein increases near a buffer/air interface and decreases near a buffer/oil interface. The range over which this fluorescence lifetime change occurs is found to be of the order several μm which is consistent with a theoretical model based on the full width at half maximum of the emission spectrum proposed by Toptygin

Regulatory assembly of the vacuolar proton pump VoV1-ATPase in yeast cells by FLIM-FRET

Science.gov (United States)

Ernst, Stefan; Batisse, Claire; Zarrabi, Nawid; Böttcher, Bettina; Börsch, Michael

2010-02-01

We investigate the reversible disassembly of VOV1-ATPase in life yeast cells by time resolved confocal FRET imaging. VOV1-ATPase in the vacuolar membrane pumps protons from the cytosol into the vacuole. VOV1-ATPase is a rotary biological nanomotor driven by ATP hydrolysis. The emerging proton gradient is used for secondary transport processes as well as for pH and Ca2+ homoeostasis in the cell. The activity of the VOV1-ATPase is regulated through assembly / disassembly processes. During starvation the two parts of VOV1-ATPase start to disassemble. This process is reversed after addition of glucose. The exact mechanisms are unknown. To follow the disassembly / reassembly in vivo we tagged two subunits C and E with different fluorescent proteins. Cellular distributions of C and E were monitored using a duty cycle-optimized alternating laser excitation scheme (DCO-ALEX) for time resolved confocal FRET-FLIM measurements.

A Full Parallel Event Driven Readout Technique for Area Array SPAD FLIM Image Sensors

Directory of Open Access Journals (Sweden)

Kaiming Nie

2016-01-01

Full Text Available This paper presents a full parallel event driven readout method which is implemented in an area array single-photon avalanche diode (SPAD image sensor for high-speed fluorescence lifetime imaging microscopy (FLIM. The sensor only records and reads out effective time and position information by adopting full parallel event driven readout method, aiming at reducing the amount of data. The image sensor includes four 8 × 8 pixel arrays. In each array, four time-to-digital converters (TDCs are used to quantize the time of photons’ arrival, and two address record modules are used to record the column and row information. In this work, Monte Carlo simulations were performed in Matlab in terms of the pile-up effect induced by the readout method. The sensor’s resolution is 16 × 16. The time resolution of TDCs is 97.6 ps and the quantization range is 100 ns. The readout frame rate is 10 Mfps, and the maximum imaging frame rate is 100 fps. The chip’s output bandwidth is 720 MHz with an average power of 15 mW. The lifetime resolvability range is 5–20 ns, and the average error of estimated fluorescence lifetimes is below 1% by employing CMM to estimate lifetimes.

Time-domain modeling of electromagnetic diffusion with a frequency-domain code

NARCIS (Netherlands)

Mulder, W.A.; Wirianto, M.; Slob, E.C.

2007-01-01

We modeled time-domain EM measurements of induction currents for marine and land applications with a frequency-domain code. An analysis of the computational complexity of a number of numerical methods shows that frequency-domain modeling followed by a Fourier transform is an attractive choice if a

Time-Domain Simulation of RF Couplers

International Nuclear Information System (INIS)

Smithe, David; Carlsson, Johan; Austin, Travis

2009-01-01

We have developed a finite-difference time-domain (FDTD) fluid-like approach to integrated plasma-and-coupler simulation [1], and show how it can be used to model LH and ICRF couplers in the MST and larger tokamaks.[2] This approach permits very accurate 3-D representation of coupler geometry, and easily includes non-axi-symmetry in vessel wall, magnetic equilibrium, and plasma density. The plasma is integrated with the FDTD Maxwell solver in an implicit solve that steps over electron time-scales, and permits tenuous plasma in the coupler itself, without any need to distinguish or interface between different regions of vacuum and/or plasma. The FDTD algorithm is also generalized to incorporate a time-domain sheath potential [3] on metal structures within the simulation, to look for situations where the sheath potential might generate local sputtering opportunities. Benchmarking of the time-domain sheath algorithm has been reported in the references. Finally, the time-domain software [4] permits the use of particles, either as field diagnostic (test particles) or to self-consistently compute plasma current from the applied RF power.

Miniaturized side-viewing imaging probe for fluorescence lifetime imaging (FLIM): validation with fluorescence dyes, tissue structural proteins and tissue specimens

OpenAIRE

Elson, DS; Jo, JA; Marcu, L

2007-01-01

We report a side viewing fibre-based endoscope that is compatible with intravascular imaging and fluorescence lifetime imaging microscopy (FLIM). The instrument has been validated through testing with fluorescent dyes and collagen and elastin powders using the Laguerre expansion deconvolution technique to calculate the fluorescence lifetimes. The instrument has also been tested on freshly excised unstained animal vascular tissues.

Reading electricity meters over the Internet; Stromzaehler uebers Internet auslesen. Flims nutzt sein Kabelnetz

Energy Technology Data Exchange (ETDEWEB)

Santner, G.

2006-07-01

This short article discusses the experience gained by the local electricity utility in Flims, Switzerland, on reading out its customers' electricity meters via the Internet. The utility uses the cable-TV network - which it also operates - to automatically transmit counter values to the utility's central server. Remote locations send data via the GPRS mobile network. The system provides consumers with monthly bills and allows the utility to plan mains-loading in a better way. The advantages of the system are discussed, in particular with respect to the liberalisation of the electricity market. The extension of the system to provide remote metering of gas and water is also discussed.

Calibration of TAMA300 in time domain

International Nuclear Information System (INIS)

Telada, Souichi; Tatsumi, Daisuke; Akutsu, Tomomi; Ando, Masaki; Kanda, Nobuyuki

2005-01-01

We could reconstruct the strain of gravitational wave signals from acquired data in the time domain by using the infinite impulse response filter technique in TAMA300. We would like to analyse the waveform in the time domain for burst-like signal, merger phase waveform of binary neutron stars, and so on. We established the way to make a continuous time-series gravitational wave strain signal. We compared the time-domain reconstruction with the Fourier-space reconstruction. Both coincided within 3% in the observation range. We could also produce the voltage signal which would be recorded by the data-acquisition system from a simulated gravitational wave. This is useful for some analyses of simulations and signal injections. We could extract the waveform of the hardware injection signal in an observational run in the time domain. The extracted waveform was similar to the injection signal

Multimodal optical coherence tomography and fluorescence lifetime imaging with interleaved excitation sources for simultaneous endogenous and exogenous fluorescence.

Science.gov (United States)

Shrestha, Sebina; Serafino, Michael J; Rico-Jimenez, Jesus; Park, Jesung; Chen, Xi; Zhaorigetu, Siqin; Walton, Brian L; Jo, Javier A; Applegate, Brian E

2016-09-01

Multimodal imaging probes a variety of tissue properties in a single image acquisition by merging complimentary imaging technologies. Exploiting synergies amongst the data, algorithms can be developed that lead to better tissue characterization than could be accomplished by the constituent imaging modalities taken alone. The combination of optical coherence tomography (OCT) with fluorescence lifetime imaging microscopy (FLIM) provides access to detailed tissue morphology and local biochemistry. The optical system described here merges 1310 nm swept-source OCT with time-domain FLIM having excitation at 355 and 532 nm. The pulses from 355 and 532 nm lasers have been interleaved to enable simultaneous acquisition of endogenous and exogenous fluorescence signals, respectively. The multimodal imaging system was validated using tissue phantoms. Nonspecific tagging with Alexa Flour 532 in a Watanbe rabbit aorta and active tagging of the LOX-1 receptor in human coronary artery, demonstrate the capacity of the system for simultaneous acquisition of OCT, endogenous FLIM, and exogenous FLIM in tissues.

Full waveform inversion in the frequency domain using classified time-domain residual wavefields

Science.gov (United States)

Son, Woohyun; Koo, Nam-Hyung; Kim, Byoung-Yeop; Lee, Ho-Young; Joo, Yonghwan

2017-04-01

We perform the acoustic full waveform inversion in the frequency domain using residual wavefields that have been separated in the time domain. We sort the residual wavefields in the time domain according to the order of absolute amplitudes. Then, the residual wavefields are separated into several groups in the time domain. To analyze the characteristics of the residual wavefields, we compare the residual wavefields of conventional method with those of our residual separation method. From the residual analysis, the amplitude spectrum obtained from the trace before separation appears to have little energy at the lower frequency bands. However, the amplitude spectrum obtained from our strategy is regularized by the separation process, which means that the low-frequency components are emphasized. Therefore, our method helps to emphasize low-frequency components of residual wavefields. Then, we generate the frequency-domain residual wavefields by taking the Fourier transform of the separated time-domain residual wavefields. With these wavefields, we perform the gradient-based full waveform inversion in the frequency domain using back-propagation technique. Through a comparison of gradient directions, we confirm that our separation method can better describe the sub-salt image than the conventional approach. The proposed method is tested on the SEG/EAGE salt-dome model. The inversion results show that our algorithm is better than the conventional gradient based waveform inversion in the frequency domain, especially for deeper parts of the velocity model.

Time versus frequency domain measurements: layered model ...

African Journals Online (AJOL)

... their high frequency content while among TEM data sets with low frequency content, the averaging times for the FEM ellipticity were shorter than the TEM quality. Keywords: ellipticity, frequency domain, frequency electromagnetic method, model parameter, orientation error, time domain, transient electromagnetic method

Time domain passivity controller for 4-channel time-delay bilateral teleoperation.

Science.gov (United States)

Rebelo, Joao; Schiele, Andre

2015-01-01

This paper presents an extension of the time-domain passivity control approach to a four-channel bilateral controller under the effects of time delays. Time-domain passivity control has been used successfully to stabilize teleoperation systems with position-force and position-position controllers; however, the performance with such control architectures is sub-optimal both with and without time delays. This work extends the network representation of the time-domain passivity controller to the four-channel architecture, which provides perfect transparency to the user without time delay. The proposed architecture is based on modelling the controllers as dependent voltage sources and using only series passivity controllers. The obtained results are shown on a one degree-of-freedom setup and illustrate the stabilization behaviour of the proposed controller when time delay is present in the communication channel.

FLIM studies of 22- and 25-NBD-cholesterol in living HEK293 cells: Plasma membrane change induced by cholesterol depletion

Czech Academy of Sciences Publication Activity Database

Ostašov, Pavel; Sýkora, Jan; Brejchová, Jana; Olžyńska, Agnieszka; Hof, Martin; Svoboda, Petr

167-168, FEB-MAR (2013), s. 62-69 ISSN 0009-3084 R&D Projects: GA ČR(CZ) GAP207/12/0919 Institutional research plan: CEZ:AV0Z50110509 Institutional support: RVO:67985823 ; RVO:61388955 Keywords : cholesterol depletion * beta-Cyclodextrin * 22-NBD-cholesterol * 25-NBD-cholesterol * FLIM studies * intact HEK293 cells Subject RIV: CE - Biochemistry; CF - Physical ; Theoretical Chemistry (UFCH-W) Impact factor: 2.593, year: 2013

Transformation Algorithm of Dielectric Response in Time-Frequency Domain

Directory of Open Access Journals (Sweden)

Ji Liu

2014-01-01

Full Text Available A transformation algorithm of dielectric response from time domain to frequency domain is presented. In order to shorten measuring time of low or ultralow frequency dielectric response characteristics, the transformation algorithm is used in this paper to transform the time domain relaxation current to frequency domain current for calculating the low frequency dielectric dissipation factor. In addition, it is shown from comparing the calculation results with actual test data that there is a coincidence for both results over a wide range of low frequencies. Meanwhile, the time domain test data of depolarization currents in dry and moist pressboards are converted into frequency domain results on the basis of the transformation. The frequency domain curves of complex capacitance and dielectric dissipation factor at the low frequency range are obtained. Test results of polarization and depolarization current (PDC in pressboards are also given at the different voltage and polarization time. It is demonstrated from the experimental results that polarization and depolarization current are affected significantly by moisture contents of the test pressboards, and the transformation algorithm is effective in ultralow frequency of 10−3 Hz. Data analysis and interpretation of the test results conclude that analysis of time-frequency domain dielectric response can be used for assessing insulation system in power transformer.

Space moving target detection using time domain feature

Science.gov (United States)

Wang, Min; Chen, Jin-yong; Gao, Feng; Zhao, Jin-yu

2018-01-01

The traditional space target detection methods mainly use the spatial characteristics of the star map to detect the targets, which can not make full use of the time domain information. This paper presents a new space moving target detection method based on time domain features. We firstly construct the time spectral data of star map, then analyze the time domain features of the main objects (target, stars and the background) in star maps, finally detect the moving targets using single pulse feature of the time domain signal. The real star map target detection experimental results show that the proposed method can effectively detect the trajectory of moving targets in the star map sequence, and the detection probability achieves 99% when the false alarm rate is about 8×10-5, which outperforms those of compared algorithms.

Impedance models in time domain

NARCIS (Netherlands)

Rienstra, S.W.

2005-01-01

Necessary conditions for an impedance function are derived. Methods available in the literature are discussed. A format with recipe is proposed for an exact impedance condition in time domain on a time grid, based on the Helmholtz resonator model. An explicit solution is given of a pulse reflecting

Flexible time domain averaging technique

Science.gov (United States)

Zhao, Ming; Lin, Jing; Lei, Yaguo; Wang, Xiufeng

2013-09-01

Time domain averaging(TDA) is essentially a comb filter, it cannot extract the specified harmonics which may be caused by some faults, such as gear eccentric. Meanwhile, TDA always suffers from period cutting error(PCE) to different extent. Several improved TDA methods have been proposed, however they cannot completely eliminate the waveform reconstruction error caused by PCE. In order to overcome the shortcomings of conventional methods, a flexible time domain averaging(FTDA) technique is established, which adapts to the analyzed signal through adjusting each harmonic of the comb filter. In this technique, the explicit form of FTDA is first constructed by frequency domain sampling. Subsequently, chirp Z-transform(CZT) is employed in the algorithm of FTDA, which can improve the calculating efficiency significantly. Since the signal is reconstructed in the continuous time domain, there is no PCE in the FTDA. To validate the effectiveness of FTDA in the signal de-noising, interpolation and harmonic reconstruction, a simulated multi-components periodic signal that corrupted by noise is processed by FTDA. The simulation results show that the FTDA is capable of recovering the periodic components from the background noise effectively. Moreover, it can improve the signal-to-noise ratio by 7.9 dB compared with conventional ones. Experiments are also carried out on gearbox test rigs with chipped tooth and eccentricity gear, respectively. It is shown that the FTDA can identify the direction and severity of the eccentricity gear, and further enhances the amplitudes of impulses by 35%. The proposed technique not only solves the problem of PCE, but also provides a useful tool for the fault symptom extraction of rotating machinery.

Finite difference time domain analysis of a chiro plasma

International Nuclear Information System (INIS)

Torres-Silva, H.; Obligado, A.; Reggiani, N.; Sakanaka, P.H.

1995-01-01

The finite difference time-domain (FDTD) method is one of the most widely used computational methods in electromagnetics. Using FDTD, Maxwell's equations are solved directly in the time domain via finite differences and time stepping. The basic approach is relatively easy to understand and is an alternative to the more usual frequency-domain approaches. (author). 5 refs

Evaluation of Damping Using Time Domain OMA Techniques

DEFF Research Database (Denmark)

Bajric, Anela; Brincker, Rune; Georgakis, Christos T.

2014-01-01

. In this paper a comparison is made of the effectiveness of three existing OMA techniques in providing accurate damping estimates for varying loadings, levels of noise, number of added measurement channels and structural damping. The evaluated techniques are derived in the time domain and are namely the Ibrahim...... Time Domain (ITD), Eigenvalue Realization Algorithm (ERA) and the Polyreference Time Domain (PTD). The response of a two degree-of-freedom (2DOF) system is numerically established from specified modal parameters with well separated and closely spaced modes. Two types of response are considered, free...

Generating Dynamic Persistence in the Time Domain

Science.gov (United States)

Guerrero, A.; Smith, L. A.; Smith, L. A.; Kaplan, D. T.

2001-12-01

Many dynamical systems present long-range correlations. Physically, these systems vary from biological to economical, including geological or urban systems. Important geophysical candidates for this type of behaviour include weather (or climate) and earthquake sequences. Persistence is characterised by slowly decaying correlation function; that, in theory, never dies out. The Persistence exponent reflects the degree of memory in the system and much effort has been expended creating and analysing methods that successfully estimate this parameter and model data that exhibits persistence. The most widely used methods for generating long correlated time series are not dynamical systems in the time domain, but instead are derived from a given spectral density. Little attention has been drawn to modelling persistence in the time domain. The time domain approach has the advantage that an observation at certain time can be calculated using previous observations which is particularly suitable when investigating the predictability of a long memory process. We will describe two of these methods in the time domain. One is a traditional approach using fractional ARIMA (autoregressive and moving average) models; the second uses a novel approach to extending a given series using random Fourier basis functions. The statistical quality of the two methods is compared, and they are contrasted with weather data which shows, reportedly, persistence. The suitability of this approach both for estimating predictability and for making predictions is discussed.

Direct time-domain techniques for transient radiation and scattering

International Nuclear Information System (INIS)

Miller, E.K.; Landt, J.A.

1976-01-01

A tutorial introduction to transient electromagnetics, focusing on direct time-domain techniques, is presented. Physical, mathematical, numerical, and experimental aspects of time-domain methods, with emphasis on wire objects excited as antennas or scatters are examined. Numerous computed examples illustrate the characteristics of direct time-domain procedures, especially where they may offer advantages over procedures in the more familiar frequency domain. These advantages include greater solution efficiency for many types of problems, the ability to handle nonlinearities, improved physical insight and interpretability, availability of wide-band information from a single calculation, and the possibility of isolating interactions among various parts of an object using time-range gating

Picosecond wide-field time-correlated single photon counting fluorescence microscopy with a delay line anode detector

Energy Technology Data Exchange (ETDEWEB)

Hirvonen, Liisa M.; Le Marois, Alix; Suhling, Klaus, E-mail: klaus.suhling@kcl.ac.uk [Department of Physics, King' s College London, Strand, London WC2R 2LS (United Kingdom); Becker, Wolfgang; Smietana, Stefan [Becker & Hickl GmbH, Nahmitzer Damm 30, 12277 Berlin (Germany); Milnes, James; Conneely, Thomas [Photek Ltd., 26 Castleham Rd, Saint Leonards-on-Sea TN38 9NS (United Kingdom); Jagutzki, Ottmar [Institut für Kernphysik, Max-von-Laue-Str. 1, 60438 Frankfurt (Germany)

2016-08-15

We perform wide-field time-correlated single photon counting-based fluorescence lifetime imaging (FLIM) with a crossed delay line anode image intensifier, where the pulse propagation time yields the photon position. This microchannel plate-based detector was read out with conventional fast timing electronics and mounted on a fluorescence microscope with total internal reflection (TIR) illumination. The picosecond time resolution of this detection system combines low illumination intensity of microwatts with wide-field data collection. This is ideal for fluorescence lifetime imaging of cell membranes using TIR. We show that fluorescence lifetime images of living HeLa cells stained with membrane dye di-4-ANEPPDHQ exhibit a reduced lifetime near the coverslip in TIR compared to epifluorescence FLIM.

A hybrid method combining the Time-Domain Method of Moments, the Time-Domain Uniform Theory of Diffraction and the FDTD

Directory of Open Access Journals (Sweden)

A. Becker

2007-06-01

Full Text Available In this paper a hybrid method combining the Time-Domain Method of Moments (TD-MoM, the Time-Domain Uniform Theory of Diffraction (TD-UTD and the Finite-Difference Time-Domain Method (FDTD is presented. When applying this new hybrid method, thin-wire antennas are modeled with the TD-MoM, inhomogeneous bodies are modelled with the FDTD and large perfectly conducting plates are modelled with the TD-UTD. All inhomogeneous bodies are enclosed in a so-called FDTD-volume and the thin-wire antennas can be embedded into this volume or can lie outside. The latter avoids the simulation of white space between antennas and inhomogeneous bodies. If the antennas are positioned into the FDTD-volume, their discretization does not need to agree with the grid of the FDTD. By using the TD-UTD large perfectly conducting plates can be considered efficiently in the solution-procedure. Thus this hybrid method allows time-domain simulations of problems including very different classes of objects, applying the respective most appropriate numerical techniques to every object.

Casimir forces in the time domain: Theory

International Nuclear Information System (INIS)

Rodriguez, Alejandro W.; McCauley, Alexander P.; Joannopoulos, John D.; Johnson, Steven G.

2009-01-01

We present a method to compute Casimir forces in arbitrary geometries and for arbitrary materials based on the finite-difference time-domain (FDTD) scheme. The method involves the time evolution of electric and magnetic fields in response to a set of current sources, in a modified medium with frequency-independent conductivity. The advantage of this approach is that it allows one to exploit existing FDTD software, without modification, to compute Casimir forces. In this paper, we focus on the derivation, implementation choices, and essential properties of the time-domain algorithm, both considered analytically and illustrated in the simplest parallel-plate geometry.

Eulerian Time-Domain Filtering for Spatial LES

Science.gov (United States)

Pruett, C. David

1997-01-01

Eulerian time-domain filtering seems to be appropriate for LES (large eddy simulation) of flows whose large coherent structures convect approximately at a common characteristic velocity; e.g., mixing layers, jets, and wakes. For these flows, we develop an approach to LES based on an explicit second-order digital Butterworth filter, which is applied in,the time domain in an Eulerian context. The approach is validated through a priori and a posteriori analyses of the simulated flow of a heated, subsonic, axisymmetric jet.

Three Dimensional Energy Transmitting Boundary in the Time Domain

Directory of Open Access Journals (Sweden)

Naohiro eNakamura

2015-11-01

Full Text Available Although the energy transmitting boundary is accurate and efficient for the FEM earthquake response analysis, it could be applied in the frequency domain only. In the previous papers, the author proposed an earthquake response analysis method using the time domain energy transmitting boundary for two dimensional problems. In this paper, this technique is expanded for three dimensional problems. The inner field is supposed to be a hexahedron shape and the approximate time domain boundary is explained, first. Next, two dimensional anti-plane time domain boundary is studied for a part of the approximate three dimensional boundary method. Then, accuracy and efficiency of the proposed method are confirmed by example problems.

Frequency-domain and time-domain methods for feedback nonlinear systems and applications to chaos control

International Nuclear Information System (INIS)

Duan Zhisheng; Wang Jinzhi; Yang Ying; Huang Lin

2009-01-01

This paper surveys frequency-domain and time-domain methods for feedback nonlinear systems and their possible applications to chaos control, coupled systems and complex dynamical networks. The absolute stability of Lur'e systems with single equilibrium and global properties of a class of pendulum-like systems with multi-equilibria are discussed. Time-domain and frequency-domain criteria for the convergence of solutions are presented. Some latest results on analysis and control of nonlinear systems with multiple equilibria and applications to chaos control are reviewed. Finally, new chaotic oscillating phenomena are shown in a pendulum-like system and a new nonlinear system with an attraction/repulsion function.

Calculation of nonzero-temperature Casimir forces in the time domain

International Nuclear Information System (INIS)

Pan, Kai; Reid, M. T. Homer; McCauley, Alexander P.; Rodriguez, Alejandro W.; White, Jacob K.; Johnson, Steven G.

2011-01-01

We show how to compute Casimir forces at nonzero temperatures with time-domain electromagnetic simulations, for example, using a finite-difference time-domain (FDTD) method. Compared to our previous zero-temperature time-domain method, only a small modification is required, but we explain that some care is required to properly capture the zero-frequency contribution. We validate the method against analytical and numerical frequency-domain calculations, and show a surprising high-temperature disappearance of a nonmonotonic behavior previously demonstrated in a pistonlike geometry.

Inversion of time-domain induced polarization data based on time-lapse concept

Science.gov (United States)

Kim, Bitnarae; Nam, Myung Jin; Kim, Hee Joon

2018-05-01

Induced polarization (IP) surveys, measuring overvoltage phenomena of the medium, are widely and increasingly performed not only for exploration of mineral resources but also for engineering applications. Among several IP survey methods such as time-domain, frequency-domain and spectral IP surveys, this study introduces a noble inversion method for time-domain IP data to recover the chargeability structure of target medium. The inversion method employs the concept of 4D inversion of time-lapse resistivity data sets, considering the fact that measured voltage in time-domain IP survey is distorted by IP effects to increase from the instantaneous voltage measured at the moment the source current injection starts. Even though the increase is saturated very fast, we can consider the saturated and instantaneous voltages as a time-lapse data set. The 4D inversion method is one of the most powerful method for inverting time-lapse resistivity data sets. Using the developed IP inversion algorithm, we invert not only synthetic but also field IP data to show the effectiveness of the proposed method by comparing the recovered chargeability models with those from linear inversion that was used for the inversion of the field data in a previous study. Numerical results confirm that the proposed inversion method generates reliable chargeability models even though the anomalous bodies have large IP effects.

Time-Reversal MUSIC Imaging with Time-Domain Gating Technique

Science.gov (United States)

Choi, Heedong; Ogawa, Yasutaka; Nishimura, Toshihiko; Ohgane, Takeo

A time-reversal (TR) approach with multiple signal classification (MUSIC) provides super-resolution for detection and localization using multistatic data collected from an array antenna system. The theory of TR-MUSIC assumes that the number of antenna elements is greater than that of scatterers (targets). Furthermore, it requires many sets of frequency-domain data (snapshots) in seriously noisy environments. Unfortunately, these conditions are not practical for real environments due to the restriction of a reasonable antenna structure as well as limited measurement time. We propose an approach that treats both noise reduction and relaxation of the transceiver restriction by using a time-domain gating technique accompanied with the Fourier transform before applying the TR-MUSIC imaging algorithm. Instead of utilizing the conventional multistatic data matrix (MDM), we employ a modified MDM obtained from the gating technique. The resulting imaging functions yield more reliable images with only a few snapshots regardless of the limitation of the antenna arrays.

A two-dimensional time domain near zone to far zone transformation

Science.gov (United States)

Luebbers, Raymond J.; Ryan, Deirdre; Beggs, John H.; Kunz, Karl S.

1991-01-01

In a previous paper, a time domain transformation useful for extrapolating 3-D near zone finite difference time domain (FDTD) results to the far zone was presented. In this paper, the corresponding 2-D transform is outlined. While the 3-D transformation produced a physically observable far zone time domain field, this is not convenient to do directly in 2-D, since a convolution would be required. However, a representative 2-D far zone time domain result can be obtained directly. This result can then be transformed to the frequency domain using a Fast Fourier Transform, corrected with a simple multiplicative factor, and used, for example, to calculate the complex wideband scattering width of a target. If an actual time domain far zone result is required it can be obtained by inverse Fourier transform of the final frequency domain result.

Metrology for terahertz time-domain spectrometers

Science.gov (United States)

Molloy, John F.; Naftaly, Mira

2015-12-01

In recent years the terahertz time-domain spectrometer (THz TDS) [1] has emerged as a key measurement device for spectroscopic investigations in the frequency range of 0.1-5 THz. To date, almost every type of material has been studied using THz TDS, including semiconductors, ceramics, polymers, metal films, liquid crystals, glasses, pharmaceuticals, DNA molecules, proteins, gases, composites, foams, oils, and many others. Measurements with a TDS are made in the time domain; conversion from the time domain data to a frequency spectrum is achieved by applying the Fourier Transform, calculated numerically using the Fast Fourier Transform (FFT) algorithm. As in many other types of spectrometer, THz TDS requires that the sample data be referenced to similarly acquired data with no sample present. Unlike frequency-domain spectrometers which detect light intensity and measure absorption spectra, a TDS records both amplitude and phase information, and therefore yields both the absorption coefficient and the refractive index of the sample material. The analysis of the data from THz TDS relies on the assumptions that: a) the frequency scale is accurate; b) the measurement of THz field amplitude is linear; and c) that the presence of the sample does not affect the performance characteristics of the instrument. The frequency scale of a THz TDS is derived from the displacement of the delay line; via FFT, positioning errors may give rise to frequency errors that are difficult to quantify. The measurement of the field amplitude in a THz TDS is required to be linear with a dynamic range of the order of 10 000. And attention must be given to the sample positioning and handling in order to avoid sample-related errors.

Application of phasor plot and autofluorescence correction for study of heterogeneous cell population

Science.gov (United States)

Szmacinski, Henryk; Toshchakov, Vladimir; Lakowicz, Joseph R.

2014-01-01

Abstract. Protein-protein interactions in cells are often studied using fluorescence resonance energy transfer (FRET) phenomenon by fluorescence lifetime imaging microscopy (FLIM). Here, we demonstrate approaches to the quantitative analysis of FRET in cell population in a case complicated by a highly heterogeneous donor expression, multiexponential donor lifetime, large contribution of cell autofluorescence, and significant presence of unquenched donor molecules that do not interact with the acceptor due to low affinity of donor-acceptor binding. We applied a multifrequency phasor plot to visualize FRET FLIM data, developed a method for lifetime background correction, and performed a detailed time-resolved analysis using a biexponential model. These approaches were applied to study the interaction between the Toll Interleukin-1 receptor (TIR) domain of Toll-like receptor 4 (TLR4) and the decoy peptide 4BB. TLR4 was fused to Cerulean fluorescent protein (Cer) and 4BB peptide was labeled with Bodipy TMRX (BTX). Phasor displays for multifrequency FLIM data are presented. The analytical procedure for lifetime background correction is described and the effect of correction on FLIM data is demonstrated. The absolute FRET efficiency was determined based on the phasor plot display and multifrequency FLIM data analysis. The binding affinity between TLR4-Cer (donor) and decoy peptide 4BB-BTX (acceptor) was estimated in a heterogeneous HeLa cell population. PMID:24770662

Time and frequency domain analyses of the Hualien Large-Scale Seismic Test

International Nuclear Information System (INIS)

Kabanda, John; Kwon, Oh-Sung; Kwon, Gunup

2015-01-01

Highlights: • Time- and frequency-domain analysis methods are verified against each other. • The two analysis methods are validated against Hualien LSST. • The nonlinear time domain (NLTD) analysis resulted in more realistic response. • The frequency domain (FD) analysis shows amplification at resonant frequencies. • The NLTD analysis requires significant modeling and computing time. - Abstract: In the nuclear industry, the equivalent-linear frequency domain analysis method has been the de facto standard procedure primarily due to the method's computational efficiency. This study explores the feasibility of applying the nonlinear time domain analysis method for the soil–structure-interaction analysis of nuclear power facilities. As a first step, the equivalency of the time and frequency domain analysis methods is verified through a site response analysis of one-dimensional soil, a dynamic impedance analysis of soil–foundation system, and a seismic response analysis of the entire soil–structure system. For the verifications, an idealized elastic soil–structure system is used to minimize variables in the comparison of the two methods. Then, the verified analysis methods are used to develop time and frequency domain models of Hualien Large-Scale Seismic Test. The predicted structural responses are compared against field measurements. The models are also analyzed with an amplified ground motion to evaluate discrepancies of the time and frequency domain analysis methods when the soil–structure system behaves beyond the elastic range. The analysis results show that the equivalent-linear frequency domain analysis method amplifies certain frequency bands and tends to result in higher structural acceleration than the nonlinear time domain analysis method. A comparison with field measurements shows that the nonlinear time domain analysis method better captures the frequency distribution of recorded structural responses than the frequency domain

Differences between time domain and Fourier domain optical coherence tomography in imaging tissues.

Science.gov (United States)

Gao, W; Wu, X

2017-11-01

It has been numerously demonstrated that both time domain and Fourier domain optical coherence tomography (OCT) can generate high-resolution depth-resolved images of living tissues and cells. In this work, we compare the common points and differences between two methods when the continuous and random properties of live tissue are taken into account. It is found that when relationships that exist between the scattered light and tissue structures are taken into account, spectral interference measurements in Fourier domain OCT (FDOCT) is more advantageous than interference fringe envelope measurements in time domain OCT (TDOCT) in the cases where continuous property of tissue is taken into account. It is also demonstrated that when random property of tissue is taken into account FDOCT measures the Fourier transform of the spatial correlation function of the refractive index and speckle phenomena will limit the effective limiting imaging resolution in both TDOCT and FDOCT. Finally, the effective limiting resolution of both TDOCT and FDOCT are given which can be used to estimate the effective limiting resolution in various practical applications. © 2017 The Authors Journal of Microscopy © 2017 Royal Microscopical Society.

Time Domain Induced Polarization

DEFF Research Database (Denmark)

Fiandaca, Gianluca; Auken, Esben; Christiansen, Anders Vest

2012-01-01

Time-domain-induced polarization has significantly broadened its field of reference during the last decade, from mineral exploration to environmental geophysics, e.g., for clay and peat identification and landfill characterization. Though, insufficient modeling tools have hitherto limited the use...... of time-domaininduced polarization for wider purposes. For these reasons, a new forward code and inversion algorithm have been developed using the full-time decay of the induced polarization response, together with an accurate description of the transmitter waveform and of the receiver transfer function......, to reconstruct the distribution of the Cole-Cole parameters of the earth. The accurate modeling of the transmitter waveform had a strong influence on the forward response, and we showed that the difference between a solution using a step response and a solution using the accurate modeling often is above 100...

Microresonator-Based Optical Frequency Combs: A Time Domain Perspective

Science.gov (United States)

2016-04-19

AFRL-AFOSR-VA-TR-2016-0165 (BRI) Microresonator-Based Optical Frequency Combs: A Time Domain Perspective Andrew Weiner PURDUE UNIVERSITY 401 SOUTH...Optical Frequency Combs: A Time Domain Perspective 5a. CONTRACT NUMBER 5b. GRANT NUMBER FA9550-12-1-0236 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data

Thermal Loss of High-Q Antennas in Time Domain vs. Frequency Domain Solver

DEFF Research Database (Denmark)

Bahramzy, Pevand; Pedersen, Gert Frølund

2014-01-01

High-Q structures pose great challenges to their loss simulations in Time Domain Solvers (TDS). Therefore, in this work the thermal loss of high-Q antennas is calculated both in TDS and Frequency Domain Solver (FDS), which are then compared with each other and with the actual measurements....... The thermal loss calculation in FDS is shown to be more accurate for high-Q antennas....

Finite-difference time-domain analysis of time-resolved terahertz spectroscopy experiments

DEFF Research Database (Denmark)

Larsen, Casper; Cooke, David G.; Jepsen, Peter Uhd

2011-01-01

In this paper we report on the numerical analysis of a time-resolved terahertz (THz) spectroscopy experiment using a modified finite-difference time-domain method. Using this method, we show that ultrafast carrier dynamics can be extracted with a time resolution smaller than the duration of the T...

Using random response input in Ibrahim Time Domain

DEFF Research Database (Denmark)

Olsen, Peter; Brincker, R.

2013-01-01

In this paper the time domain technique Ibrahim Time Domain (ITD) is used to analyze random time data. ITD is known to be a technique for identification of output only systems. The traditional formulation of ITD is claimed to be limited, when identifying closely spaced modes, because....... In this article it is showed that when using the modified ITD random time data can be analyzed. The application of the technique is displayed by a case study, with simulations and experimental data....... of the technique being Single Input Multiple Output (SIMO). It has earlier been showed that when modifying ITD with Toeplitz matrix averaging. Identification of time data with closely spaced modes is improved. In the traditional formulation of ITD the time data has to be free decays or impulse response functions...

Parametric time-frequency domain spatial audio

CERN Document Server

Delikaris-Manias, Symeon; Politis, Archontis

2018-01-01

This book provides readers with the principles and best practices in spatial audio signal processing. It describes how sound fields and their perceptual attributes are captured and analyzed within the time-frequency domain, how essential representation parameters are coded, and how such signals are efficiently reproduced for practical applications. The book is split into four parts starting with an overview of the fundamentals. It then goes on to explain the reproduction of spatial sound before offering an examination of signal-dependent spatial filtering. The book finishes with coverage of both current and future applications and the direction that spatial audio research is heading in. Parametric Time-frequency Domain Spatial Audio focuses on applications in entertainment audio, including music, home cinema, and gaming--covering the capturing and reproduction of spatial sound as well as its generation, transduction, representation, transmission, and perception. This book will teach readers the tools needed...

Multiple Shooting and Time Domain Decomposition Methods

CERN Document Server

Geiger, Michael; Körkel, Stefan; Rannacher, Rolf

2015-01-01

This book offers a comprehensive collection of the most advanced numerical techniques for the efficient and effective solution of simulation and optimization problems governed by systems of time-dependent differential equations. The contributions present various approaches to time domain decomposition, focusing on multiple shooting and parareal algorithms.  The range of topics covers theoretical analysis of the methods, as well as their algorithmic formulation and guidelines for practical implementation. Selected examples show that the discussed approaches are mandatory for the solution of challenging practical problems. The practicability and efficiency of the presented methods is illustrated by several case studies from fluid dynamics, data compression, image processing and computational biology, giving rise to possible new research topics.  This volume, resulting from the workshop Multiple Shooting and Time Domain Decomposition Methods, held in Heidelberg in May 2013, will be of great interest to applied...

Architecture for time or transform domain decoding of reed-solomon codes

Science.gov (United States)

Shao, Howard M. (Inventor); Truong, Trieu-Kie (Inventor); Hsu, In-Shek (Inventor); Deutsch, Leslie J. (Inventor)

1989-01-01

Two pipeline (255,233) RS decoders, one a time domain decoder and the other a transform domain decoder, use the same first part to develop an errata locator polynomial .tau.(x), and an errata evaluator polynominal A(x). Both the time domain decoder and transform domain decoder have a modified GCD that uses an input multiplexer and an output demultiplexer to reduce the number of GCD cells required. The time domain decoder uses a Chien search and polynomial evaluator on the GCD outputs .tau.(x) and A(x), for the final decoding steps, while the transform domain decoder uses a transform error pattern algorithm operating on .tau.(x) and the initial syndrome computation S(x), followed by an inverse transform algorithm in sequence for the final decoding steps prior to adding the received RS coded message to produce a decoded output message.

Modern EMC analysis I time-domain computational schemes

CERN Document Server

Kantartzis, Nikolaos V

2008-01-01

The objective of this two-volume book is the systematic and comprehensive description of the most competitive time-domain computational methods for the efficient modeling and accurate solution of contemporary real-world EMC problems. Intended to be self-contained, it performs a detailed presentation of all well-known algorithms, elucidating on their merits or weaknesses, and accompanies the theoretical content with a variety of applications. Outlining the present volume, the analysis covers the theory of the finite-difference time-domain, the transmission-line matrix/modeling, and the finite i

High resolution multiplexed functional imaging in live embryos (Conference Presentation)

Science.gov (United States)

Xu, Dongli; Zhou, Weibin; Peng, Leilei

2017-02-01

Fourier multiplexed fluorescence lifetime imaging (FmFLIM) scanning laser optical tomography (FmFLIM-SLOT) combines FmFLIM and Scanning laser optical tomography (SLOT) to perform multiplexed 3D FLIM imaging of live embryos. The system had demonstrate multiplexed functional imaging of zebrafish embryos genetically express Foster Resonant Energy Transfer (FRET) sensors. However, previous system has a 20 micron resolution because the focused Gaussian beam diverges quickly from the focused plane, makes it difficult to achieve high resolution imaging over a long projection depth. Here, we present a high-resolution FmFLIM-SLOT system with achromatic Bessel beam, which achieves 3 micron resolution in 3D deep tissue imaging. In Bessel-FmFLIM-SLOT, multiple laser excitation lines are firstly intensity modulated by a Michelson interferometer with a spinning polygon mirror optical delay line, which enables Fourier multiplexed multi-channel lifetime measurements. Then, a spatial light modulator and a prism are used to transform the modulated Gaussian laser beam to an achromatic Bessel beam. The achromatic Bessel beam scans across the whole specimen with equal angular intervals as sample rotated. After tomography reconstruction and the frequency domain lifetime analysis method, both the 3D intensity and lifetime image of multiple excitation-emission can be obtained. Using Bessel-FmFLIM-SLOT system, we performed cellular-resolution FLIM tomography imaging of live zebrafish embryo. Genetically expressed FRET sensors in these embryo will allow non-invasive observation of multiple biochemical processes in vivo.

A higher order space-time Galerkin scheme for time domain integral equations

KAUST Repository

Pray, Andrew J.

2014-12-01

Stability of time domain integral equation (TDIE) solvers has remained an elusive goal formany years. Advancement of this research has largely progressed on four fronts: 1) Exact integration, 2) Lubich quadrature, 3) smooth temporal basis functions, and 4) space-time separation of convolutions with the retarded potential. The latter method\\'s efficacy in stabilizing solutions to the time domain electric field integral equation (TD-EFIE) was previously reported for first-order surface descriptions (flat elements) and zeroth-order functions as the temporal basis. In this work, we develop the methodology necessary to extend the scheme to higher order surface descriptions as well as to enable its use with higher order basis functions in both space and time. These basis functions are then used in a space-time Galerkin framework. A number of results are presented that demonstrate convergence in time. The viability of the space-time separation method in producing stable results is demonstrated experimentally for these examples.

A higher order space-time Galerkin scheme for time domain integral equations

KAUST Repository

Pray, Andrew J.; Beghein, Yves; Nair, Naveen V.; Cools, Kristof; Bagci, Hakan; Shanker, Balasubramaniam

2014-01-01

Stability of time domain integral equation (TDIE) solvers has remained an elusive goal formany years. Advancement of this research has largely progressed on four fronts: 1) Exact integration, 2) Lubich quadrature, 3) smooth temporal basis functions, and 4) space-time separation of convolutions with the retarded potential. The latter method's efficacy in stabilizing solutions to the time domain electric field integral equation (TD-EFIE) was previously reported for first-order surface descriptions (flat elements) and zeroth-order functions as the temporal basis. In this work, we develop the methodology necessary to extend the scheme to higher order surface descriptions as well as to enable its use with higher order basis functions in both space and time. These basis functions are then used in a space-time Galerkin framework. A number of results are presented that demonstrate convergence in time. The viability of the space-time separation method in producing stable results is demonstrated experimentally for these examples.

A novel method for sensing metastatic cells in the CSF of pediatric population with medulloblastoma by frequency domain FLIM system

Science.gov (United States)

Yahav, Gilad; Fixler, Dror; Gershanov, Sivan; Goldenberg-Cohen, Nitza

2016-03-01

Brain tumors are the second leading cause of cancer-related deaths in children, after leukemia. Patients with cancer in the central nervous system have a very low recovery rate. Today known imaging and cytology techniques are not always sensitive enough for an early detection of both tumor and its metastatic spread, moreover the detection is generally limited, reviewer dependent and takes a relatively long time. Medulloblastoma (MB) is the most common malignant brain tumor in children. The aim of our talk is to present the frequency domain fluorescence lifetime imaging microscopy system as a possible method for an early detection of MB and its metastatic spread in the cerebrospinal fluids within the pediatric population.

Drug detection by terahertz time-domain spectroscopy

International Nuclear Information System (INIS)

Duan Ruixin; Zhu Yiming; Zhao Hongwei

2013-01-01

Due to unique spectral region, functional imaging ability, excellent penetration and safety characteristics of terahertz radiation, the terahertz technology rapidly becomes a vital method to detect and analyze drugs. In this paper, firstly, we identify the functional groups of anti-diabetic drugs by density functional theory (DFT), HIPHOP models and experimental results from terahertz time-domain spectroscopy measurements. Secondly, we identify four kinds of herbs of radix curcumae by using the support vector machine (SVM) analysis. Besides, we analyze the absorption of anhydrous and hydrous glucose, and determine the state of water in the crystalized D-glucose·H 2 O through the results of differential scanning calorimetry measurement. Finally, we summarize the advantages and disadvantages of terahertz time-domain spectroscopy method in drug detection and analyzing. (authors)

Explicit solution of Calderon preconditioned time domain integral equations

KAUST Repository

Ulku, Huseyin Arda

2013-07-01

An explicit marching on-in-time (MOT) scheme for solving Calderon-preconditioned time domain integral equations is proposed. The scheme uses Rao-Wilton-Glisson and Buffa-Christiansen functions to discretize the domain and range of the integral operators and a PE(CE)m type linear multistep to march on in time. Unlike its implicit counterpart, the proposed explicit solver requires the solution of an MOT system with a Gram matrix that is sparse and well-conditioned independent of the time step size. Numerical results demonstrate that the explicit solver maintains its accuracy and stability even when the time step size is chosen as large as that typically used by an implicit solver. © 2013 IEEE.

Time Domain Partitioning of Electricity Production Cost Simulations

Energy Technology Data Exchange (ETDEWEB)

Barrows, C. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hummon, M. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Jones, W. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hale, E. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2014-01-01

Production cost models are often used for planning by simulating power system operations over long time horizons. The simulation of a day-ahead energy market can take several weeks to compute. Tractability improvements are often made through model simplifications, such as: reductions in transmission modeling detail, relaxation of commitment variable integrality, reductions in cost modeling detail, etc. One common simplification is to partition the simulation horizon so that weekly or monthly horizons can be simulated in parallel. However, horizon partitions are often executed with overlap periods of arbitrary and sometimes zero length. We calculate the time domain persistence of historical unit commitment decisions to inform time domain partitioning of production cost models. The results are implemented using PLEXOS production cost modeling software in an HPC environment to improve the computation time of simulations while maintaining solution integrity.

Time-domain Green's Function Method for three-dimensional nonlinear subsonic flows

Science.gov (United States)

Tseng, K.; Morino, L.

1978-01-01

The Green's Function Method for linearized 3D unsteady potential flow (embedded in the computer code SOUSSA P) is extended to include the time-domain analysis as well as the nonlinear term retained in the transonic small disturbance equation. The differential-delay equations in time, as obtained by applying the Green's Function Method (in a generalized sense) and the finite-element technique to the transonic equation, are solved directly in the time domain. Comparisons are made with both linearized frequency-domain calculations and existing nonlinear results.

A multi-domain spectral method for time-fractional differential equations

Science.gov (United States)

Chen, Feng; Xu, Qinwu; Hesthaven, Jan S.

2015-07-01

This paper proposes an approach for high-order time integration within a multi-domain setting for time-fractional differential equations. Since the kernel is singular or nearly singular, two main difficulties arise after the domain decomposition: how to properly account for the history/memory part and how to perform the integration accurately. To address these issues, we propose a novel hybrid approach for the numerical integration based on the combination of three-term-recurrence relations of Jacobi polynomials and high-order Gauss quadrature. The different approximations used in the hybrid approach are justified theoretically and through numerical examples. Based on this, we propose a new multi-domain spectral method for high-order accurate time integrations and study its stability properties by identifying the method as a generalized linear method. Numerical experiments confirm hp-convergence for both time-fractional differential equations and time-fractional partial differential equations.

Time- and Frequency-domain Comparisons of the Wavepiston Wave Energy Converter

DEFF Research Database (Denmark)

Read, Robert; Bingham, Harry

Analysis of wave-energy converters is most frequently undertaken in the time-domain. This formulation allows the direct inclusion of nonlinear time-varying loads such as power take-off (PTO) reactions, mooring forces, and viscous drag. However, integrating the governing equations of motion...... forces arising from both the PTO reactions and the non-negligible viscous drag acting on the plate. Equivalent linear damping coeffcients are used to model these forces in the frequency domain, while they are included explicitly in the time domain. The main idea of this paper is to quantify...

DRK methods for time-domain oscillator simulation

NARCIS (Netherlands)

Sevat, M.F.; Houben, S.H.M.J.; Maten, ter E.J.W.; Di Bucchianico, A.; Mattheij, R.M.M.; Peletier, M.A.

2006-01-01

This paper presents a new Runge-Kutta type integration method that is well-suited for time-domain simulation of oscillators. A unique property of the new method is that its damping characteristics can be controlled by a continuous parameter.

Time-domain multiple-quantum NMR

International Nuclear Information System (INIS)

Weitekamp, D.P.

1982-11-01

The development of time-domain multiple-quantum nuclear magnetic resonance is reviewed through mid 1982 and some prospects for future development are indicated. Particular attention is given to the problem of obtaining resolved, interpretable, many-quantum spectra for anisotropic magnetically isolated systems of coupled spins. New results are presented on a number of topics including the optimization of multiple-quantum-line intensities, analysis of noise in two-dimensional spectroscopy, and the use of order-selective excitation for cross polarization between nuclear-spin species

Fast time- and frequency-domain finite-element methods for electromagnetic analysis

Science.gov (United States)

Lee, Woochan

Fast electromagnetic analysis in time and frequency domain is of critical importance to the design of integrated circuits (IC) and other advanced engineering products and systems. Many IC structures constitute a very large scale problem in modeling and simulation, the size of which also continuously grows with the advancement of the processing technology. This results in numerical problems beyond the reach of existing most powerful computational resources. Different from many other engineering problems, the structure of most ICs is special in the sense that its geometry is of Manhattan type and its dielectrics are layered. Hence, it is important to develop structure-aware algorithms that take advantage of the structure specialties to speed up the computation. In addition, among existing time-domain methods, explicit methods can avoid solving a matrix equation. However, their time step is traditionally restricted by the space step for ensuring the stability of a time-domain simulation. Therefore, making explicit time-domain methods unconditionally stable is important to accelerate the computation. In addition to time-domain methods, frequency-domain methods have suffered from an indefinite system that makes an iterative solution difficult to converge fast. The first contribution of this work is a fast time-domain finite-element algorithm for the analysis and design of very large-scale on-chip circuits. The structure specialty of on-chip circuits such as Manhattan geometry and layered permittivity is preserved in the proposed algorithm. As a result, the large-scale matrix solution encountered in the 3-D circuit analysis is turned into a simple scaling of the solution of a small 1-D matrix, which can be obtained in linear (optimal) complexity with negligible cost. Furthermore, the time step size is not sacrificed, and the total number of time steps to be simulated is also significantly reduced, thus achieving a total cost reduction in CPU time. The second contribution

MULTILOOP PI CONTROLLER FOR ACHIEVING SIMULTANEOUS TIME AND FREQUENCY DOMAIN SPECIFICATIONS

Directory of Open Access Journals (Sweden)

M. SENTHILKUMAR

2015-08-01

Full Text Available Most of the controllers in control system are designed to satisfy either time domain or frequency domain specifications. This work presents the computation of a multiloop PI controller for achieving time and frequency domain specifications simultaneously. The desired time and frequency domain measures are to be specified initially to the design. To obtain the desired value of the performance measures the graphical relationship between the PI controller and the performance criteria is given. Thus by using graphical method a set of PI controller parameters to meet the desired performance measures are obtained in an effective and simpler way. The coupled tank has become a classic design of control engineering for multivariable process. The proposed control strategy has been implemented in the same coupled tank process and validated through simulation studies.

Molecular Frame Reconstruction Using Time-Domain Photoionization Interferometry.

Science.gov (United States)

Marceau, Claude; Makhija, Varun; Platzer, Dominique; Naumov, A Yu; Corkum, P B; Stolow, Albert; Villeneuve, D M; Hockett, Paul

2017-08-25

Photoionization of molecular species is, essentially, a multipath interferometer with both experimentally controllable and intrinsic molecular characteristics. In this work, XUV photoionization of impulsively aligned molecular targets (N_{2}) is used to provide a time-domain route to "complete" photoionization experiments, in which the rotational wave packet controls the geometric part of the photoionization interferometer. The data obtained is sufficient to determine the magnitudes and phases of the ionization matrix elements for all observed channels, and to reconstruct molecular frame interferograms from lab frame measurements. In principle, this methodology provides a time-domain route to complete photoionization experiments and the molecular frame, which is generally applicable to any molecule (no prerequisites), for all energies and ionization channels.

Fast damage imaging using the time-reversal technique in the frequency–wavenumber domain

International Nuclear Information System (INIS)

Zhu, R; Huang, G L; Yuan, F G

2013-01-01

The time-reversal technique has been successfully used in structural health monitoring (SHM) for quantitative imaging of damage. However, the technique is very time-consuming when it is implemented in the time domain. In this paper, we study the technique in the frequency–wavenumber (f–k) domain for fast real-time imaging of multiple damage sites in plates using scattered flexural plate waves. Based on Mindlin plate theory, the time reversibility of dispersive flexural waves in an isotropic plate is theoretically investigated in the f–k domain. A fast damage imaging technique is developed by using the cross-correlation between the back-propagated scattered wavefield and the incident wavefield in the frequency domain. Numerical simulations demonstrate that the proposed technique cannot only localize multiple damage sites but also potentially identify their sizes. Moreover, the time-reversal technique in the f–k domain is about two orders of magnitude faster than the method in the time domain. Finally, experimental testing of an on-line SHM system with a sparse piezoelectric sensor array is conducted for fast multiple damage identification using the proposed technique. (paper)

A Time Domain Waveform for Testing General Relativity

International Nuclear Information System (INIS)

Huwyler, Cédric; Jetzer, Philippe; Porter, Edward K

2015-01-01

Gravitational-wave parameter estimation is only as good as the theory the waveform generation models are based upon. It is therefore crucial to test General Relativity (GR) once data becomes available. Many previous works, such as studies connected with the ppE framework by Yunes and Pretorius, rely on the stationary phase approximation (SPA) to model deviations from GR in the frequency domain. As Fast Fourier Transform algorithms have become considerably faster and in order to circumvent possible problems with the SPA, we test GR with corrected time domain waveforms instead of SPA waveforms. Since a considerable amount of work has been done already in the field using SPA waveforms, we establish a connection between leading-order-corrected waveforms in time and frequency domain, concentrating on phase-only corrected terms. In a Markov Chain Monte Carlo study, whose results are preliminary and will only be available later, we will assess the ability of the eLISA detector to measure deviations from GR for signals coming from supermassive black hole inspirals using these corrected waveforms. (paper)

Numerical simulation of electromagnetic wave propagation using time domain meshless method

International Nuclear Information System (INIS)

Ikuno, Soichiro; Fujita, Yoshihisa; Itoh, Taku; Nakata, Susumu; Nakamura, Hiroaki; Kamitani, Atsushi

2012-01-01

The electromagnetic wave propagation in various shaped wave guide is simulated by using meshless time domain method (MTDM). Generally, Finite Differential Time Domain (FDTD) method is applied for electromagnetic wave propagation simulation. However, the numerical domain should be divided into rectangle meshes if FDTD method is applied for the simulation. On the other hand, the node disposition of MTDM can easily describe the structure of arbitrary shaped wave guide. This is the large advantage of the meshless time domain method. The results of computations show that the damping rate is stably calculated in case with R < 0.03, where R denotes a support radius of the weight function for the shape function. And the results indicate that the support radius R of the weight functions should be selected small, and monomials must be used for calculating the shape functions. (author)

Methodology for time-domain estimation of storm time geoelectric fields using the 3-D magnetotelluric response tensors

Science.gov (United States)

Kelbert, Anna; Balch, Christopher C.; Pulkkinen, Antti; Egbert, Gary D.; Love, Jeffrey J.; Rigler, E. Joshua; Fujii, Ikuko

2017-07-01

Geoelectric fields at the Earth's surface caused by magnetic storms constitute a hazard to the operation of electric power grids and related infrastructure. The ability to estimate these geoelectric fields in close to real time and provide local predictions would better equip the industry to mitigate negative impacts on their operations. Here we report progress toward this goal: development of robust algorithms that convolve a magnetic storm time series with a frequency domain impedance for a realistic three-dimensional (3-D) Earth, to estimate the local, storm time geoelectric field. Both frequency domain and time domain approaches are presented and validated against storm time geoelectric field data measured in Japan. The methods are then compared in the context of a real-time application.

Reduced order for nuclear reactor model in frequency and time domain

International Nuclear Information System (INIS)

Nugroho, D.H.

1997-01-01

In control system theory, a model can be represented by frequency or time domain. In frequency domain, the model was represented by transfer function. in time domain, the model was represented by state space. for the sake of simplification in computation, it is necessary to reduce the model order. the main aim of this research is to find the best in nuclear reactor model. Model order reduction in frequency domain can be done utilizing pole-zero cancellation method; while in time domain utilizing balanced aggregation method the balanced aggregation method was developed by moore (1981). In this paper, the two kinds of method were applied to reduce a nuclear reactor model which was constructed by neutron dynamics and heat transfer equations. to validate that the model characteristics were not change when model order reduction applied, the response was utilized for full and reduced order. it was shown that the nuclear reactor order model can be reduced from order 8 to 2 order 2 is the best order for nuclear reactor model

Time domain optical spectrometry with fiber optic waveguides

International Nuclear Information System (INIS)

Whitten, W.B.

1983-01-01

Spectrometers which use optical fibers to obtain time domain spectral dispersion are reviewed. Pulse transmission through fiber optic waveguides is discussed and the basic requirements for sources and detectors are given. Multiplex spectrometry and time-of-flight spectrometry are then discussed. Resolution, fiber requirements, instrumentation and specific spectrometers are presented

Time-domain representation of frequency-dependent foundation impedance functions

Science.gov (United States)

Safak, E.

2006-01-01

Foundation impedance functions provide a simple means to account for soil-structure interaction (SSI) when studying seismic response of structures. Impedance functions represent the dynamic stiffness of the soil media surrounding the foundation. The fact that impedance functions are frequency dependent makes it difficult to incorporate SSI in standard time-history analysis software. This paper introduces a simple method to convert frequency-dependent impedance functions into time-domain filters. The method is based on the least-squares approximation of impedance functions by ratios of two complex polynomials. Such ratios are equivalent, in the time-domain, to discrete-time recursive filters, which are simple finite-difference equations giving the relationship between foundation forces and displacements. These filters can easily be incorporated into standard time-history analysis programs. Three examples are presented to show the applications of the method.

Real-time all-optical OFDM transmission system based on time-domain optical fourier transformation

DEFF Research Database (Denmark)

Guan, Pengyu; Kong, Deming; Røge, Kasper Meldgaard

2014-01-01

We propose a novel simple all-optical OFDM transmission system based on time-domain OFT using time-lenses. A real-time 160 Gbit/s DPSK OFDM transmission with 16 decorrelated data subcarriers is successfully demonstrated over 100 km....

Microprocessor-controlled time domain reflectometer for dynamic shock position measurements

International Nuclear Information System (INIS)

Virchow, C.F.; Conrad, G.E.; Holt, D.M.; Hodson, E.K.

1980-01-01

Time-domain reflectometry is used in a novel way to measure dynamically shock propagation in various media. The primary component in this measurement system is a digital time domain reflectometer, which uses local intelligence, a Motorola 6800 microprocessor, to make the unit adaptable and versatile. The recorder, its operating theory and its method of implementation are described and typical data are reviewed. Applications include nuclear explosion yield estimates and explosive energy flow measurements

Analysis of noise in energy-dispersive spectrometers using time-domain methods

CERN Document Server

Goulding, F S

2002-01-01

This paper presents an integrated time domain approach to the optimization of the signal-to-noise ratio in all spectrometer systems that contain a detector that converts incoming quanta of radiation into electrical pulse signals that are amplified and shaped by an electronic pulse shaper. It allows analysis of normal passive pulse shapers as well as time-variant systems where switching of shaping elements occurs in synchronism with the signal. It also deals comfortably with microcalorimeters (sometimes referred to as bolometers), where noise-determining elements, such as the temperature-sensing element's resistance and temperature, change with time in the presence of a signal. As part of the purely time-domain approach, a new method of calculating the Johnson noise in resistors using only the statistics of electron motion is presented. The result is a time-domain analog of the Nyquist formula.

THz time domain spectroscopy of biomolecular conformational modes

International Nuclear Information System (INIS)

Markelz, Andrea; Whitmire, Scott; Hillebrecht, Jay; Birge, Robert

2002-01-01

We discuss the use of terahertz time domain spectroscopy for studies of conformational flexibility and conformational change in biomolecules. Protein structural dynamics are vital to biological function with protein flexibility affecting enzymatic reaction rates and sensory transduction cycling times. Conformational mode dynamics occur on the picosecond timescale and with the collective vibrational modes associated with these large scale structural motions in the 1-100 cm -1 range. We have performed THz time domain spectroscopy (TTDS) of several biomolecular systems to explore the sensitivity of TTDS to distinguish different molecular species, different mutations within a single species and different conformations of a given biomolecule. We compare the measured absorbances to normal mode calculations and find that the TTDS absorbance reflects the density of normal modes determined by molecular mechanics calculations, and is sensitive to both conformation and mutation. These early studies demonstrate some of the advantages and limitations of using TTDS for the study of biomolecules

Structural Time Domain Identification Toolbox User's Guide

DEFF Research Database (Denmark)

Andersen, P.; Kirkegaard, Poul Henning; Brincker, Rune

This manual describes the Structural Time Domain Identification toolbox for use with MA TLAB. This version of the tool box has been developed using the PC-based MA TLAB version 4.2c, but is compatible with prior versions of MATLAB and UNIX-based versions. The routines of the toolbox are the so...

Time-resolved single-shot terahertz time-domain spectroscopy for ultrafast irreversible processes

Science.gov (United States)

Zhai, Zhao-Hui; Zhong, Sen-Cheng; Li, Jun; Zhu, Li-Guo; Meng, Kun; Li, Jiang; Liu, Qiao; Peng, Qi-Xian; Li, Ze-Ren; Zhao, Jian-Heng

2016-09-01

Pulsed terahertz spectroscopy is suitable for spectroscopic diagnostics of ultrafast events. However, the study of irreversible or single shot ultrafast events requires ability to record transient properties at multiple time delays, i.e., time resolved at single shot level, which is not available currently. Here by angular multiplexing use of femtosecond laser pulses, we developed and demonstrated a time resolved, transient terahertz time domain spectroscopy technique, where burst mode THz pulses were generated and then detected in a single shot measurement manner. The burst mode THz pulses contain 2 sub-THz pulses, and the time gap between them is adjustable up to 1 ns with picosecond accuracy, thus it can be used to probe the single shot event at two different time delays. The system can detect the sub-THz pulses at 0.1 THz-2.5 THz range with signal to noise ratio (SNR) of ˜400 and spectrum resolution of 0.05 THz. System design was described here, and optimizations of single shot measurement of THz pulses were discussed in detail. Methods to improve SNR were also discussed in detail. A system application was demonstrated where pulsed THz signals at different time delays of the ultrafast process were successfully acquired within single shot measurement. This time resolved transient terahertz time domain spectroscopy technique provides a new diagnostic tool for irreversible or single shot ultrafast events where dynamic information can be extracted at terahertz range within one-shot experiment.

Measuring time and risk preferences: Reliability, stability, domain specificity

NARCIS (Netherlands)

Wölbert, E.M.; Riedl, A.M.

2013-01-01

To accurately predict behavior economists need reliable measures of individual time preferences and attitudes toward risk and typically need to assume stability of these characteristics over time and across decision domains. We test the reliability of two choice tasks for eliciting discount rates,

On-chip Brownian relaxation measurements of magnetic nanobeads in the time domain

DEFF Research Database (Denmark)

Østerberg, Frederik Westergaard; Rizzi, Giovanni; Hansen, Mikkel Fougt

2013-01-01

the time and frequency domain methods on Brownian relaxation detection of clustering of streptavidin coated magnetic beads in the presence of different concentrations of biotin-conjugated bovine serum albumin and obtain comparable results. In the time domain, a measurement is carried out in less than 30 s...

DWDM-TO-OTDM Conversion by Time-Domain Optical Fourier Transformation

DEFF Research Database (Denmark)

Mulvad, Hans Christian Hansen; Hu, Hao; Galili, Michael

2011-01-01

We propose DWDM-OTDM conversion by time-domain optical Fourier transformation. Error-free conversion of a 16×10 Gbit/s 50 GHz-spacing DWDM data signal to a 160 Gbit/s OTDM signal with a 2.1 dB average penalty is demonstrated.......We propose DWDM-OTDM conversion by time-domain optical Fourier transformation. Error-free conversion of a 16×10 Gbit/s 50 GHz-spacing DWDM data signal to a 160 Gbit/s OTDM signal with a 2.1 dB average penalty is demonstrated....

Time-Domain Optical Fourier Transformation for OTDM-DWDM and DWDM-OTDM Conversion

DEFF Research Database (Denmark)

Mulvad, Hans Christian Hansen; Palushani, Evarist; Galili, Michael

2011-01-01

Applications of time-domain optical Fourier transformation (OFT) in ultra-high-speed optical time-division multiplexed systems (OTDM) are reviewed, with emphasis on the recent demonstrations of OFT-based conversion between the OTDM and DWDM formats.......Applications of time-domain optical Fourier transformation (OFT) in ultra-high-speed optical time-division multiplexed systems (OTDM) are reviewed, with emphasis on the recent demonstrations of OFT-based conversion between the OTDM and DWDM formats....

Partial Fourier analysis of time-harmonic Maxwell's equations in axisymmetric domains

International Nuclear Information System (INIS)

Nkemzi, Boniface

2003-01-01

We analyze the Fourier method for treating time-harmonic Maxwell's equations in three-dimensional axisymmetric domains with non-axisymmetric data. The Fourier method reduces the three-dimensional boundary value problem to a system of decoupled two-dimensional boundary value problems on the plane meridian domain of the axisymmetric domain. The reduction process is fully described and suitable weighted spaces are introduced on the meridian domain to characterize the two-dimensional solutions. In particular, existence and uniqueness of solutions of the two-dimensional problems is proved and a priori estimates for the solutions are given. (author)

Assessment of perceptual diffuseness in the time domain

DEFF Research Database (Denmark)

Garcia, Julian Martinez-Villalba; Jeong, Cheol-Ho; Brunskog, Jonas

2017-01-01

This study proposes a numerical and experimental framework for evaluating the perceptual aspect of the diffuse field condition with intended final use in music auditoria. Multiple Impulse Responses are simulated based on the time domain Poisson process with increasing reflection density. Different...

Time domain calculation of connector loads of a very large floating structure

Science.gov (United States)

Gu, Jiayang; Wu, Jie; Qi, Enrong; Guan, Yifeng; Yuan, Yubo

2015-06-01

Loads generated after an air crash, ship collision, and other accidents may destroy very large floating structures (VLFSs) and create additional connector loads. In this study, the combined effects of ship collision and wave loads are considered to establish motion differential equations for a multi-body VLFS. A time domain calculation method is proposed to calculate the connector load of the VLFS in waves. The Longuet-Higgins model is employed to simulate the stochastic wave load. Fluid force and hydrodynamic coefficient are obtained with DNV Sesam software. The motion differential equation is calculated by applying the time domain method when the frequency domain hydrodynamic coefficient is converted into the memory function of the motion differential equation of the time domain. As a result of the combined action of wave and impact loads, high-frequency oscillation is observed in the time history curve of the connector load. At wave directions of 0° and 75°, the regularities of the time history curves of the connector loads in different directions are similar and the connector loads of C1 and C2 in the X direction are the largest. The oscillation load is observed in the connector in the Y direction at a wave direction of 75° and not at 0°. This paper presents a time domain calculation method of connector load to provide a certain reference function for the future development of Chinese VLFS

Simulation of compressible viscous flow in time-dependent domains

Czech Academy of Sciences Publication Activity Database

Česenek, J.; Feistauer, M.; Horáček, Jaromír; Kučera, V.; Prokopova, J.

2013-01-01

Roč. 219, č. 13 (2013), s. 7139-7150 ISSN 0096-3003 R&D Projects: GA ČR(CZ) GAP101/11/0207 Institutional support: RVO:61388998 Keywords : time dependent domain * ALE method * semi-implicit time discretization * shock indicator Subject RIV: BI - Acoustics Impact factor: 1.600, year: 2013

Parallel time domain solvers for electrically large transient scattering problems

KAUST Repository

Liu, Yang

2014-09-26

Marching on in time (MOT)-based integral equation solvers represent an increasingly appealing avenue for analyzing transient electromagnetic interactions with large and complex structures. MOT integral equation solvers for analyzing electromagnetic scattering from perfect electrically conducting objects are obtained by enforcing electric field boundary conditions and implicitly time advance electric surface current densities by iteratively solving sparse systems of equations at all time steps. Contrary to finite difference and element competitors, these solvers apply to nonlinear and multi-scale structures comprising geometrically intricate and deep sub-wavelength features residing atop electrically large platforms. Moreover, they are high-order accurate, stable in the low- and high-frequency limits, and applicable to conducting and penetrable structures represented by highly irregular meshes. This presentation reviews some recent advances in the parallel implementations of time domain integral equation solvers, specifically those that leverage multilevel plane-wave time-domain algorithm (PWTD) on modern manycore computer architectures including graphics processing units (GPUs) and distributed memory supercomputers. The GPU-based implementation achieves at least one order of magnitude speedups compared to serial implementations while the distributed parallel implementation are highly scalable to thousands of compute-nodes. A distributed parallel PWTD kernel has been adopted to solve time domain surface/volume integral equations (TDSIE/TDVIE) for analyzing transient scattering from large and complex-shaped perfectly electrically conducting (PEC)/dielectric objects involving ten million/tens of millions of spatial unknowns.

MPP1 directly interacts with flotillins in erythrocyte membrane - Possible mechanism of raft domain formation.

Science.gov (United States)

Biernatowska, Agnieszka; Augoff, Katarzyna; Podkalicka, Joanna; Tabaczar, Sabina; Gajdzik-Nowak, Weronika; Czogalla, Aleksander; Sikorski, Aleksander F

2017-11-01

Flotillins are prominent, oligomeric protein components of erythrocyte (RBC) membrane raft domains and are considered to play an important structural role in lateral organization of the plasma membrane. In our previous work on erythroid membranes and giant plasma membrane vesicles (GPMVs) derived from them we have shown that formation of functional domains (resting state rafts) depends on the presence of membrane palmitoylated protein 1 (MPP1/p55), pointing to its new physiological role. Exploration of the molecular mechanism of MPP1 function in organizing membrane domains described here, through searching for its molecular partners in RBC membrane by using different methods, led to the identification of the raft-marker proteins, flotillin 1 and flotillin 2, as hitherto unreported direct MPP1 binding-partners in the RBC membrane. These proteins are found in high molecular-weight complexes in native RBC membrane and, significantly, their presence was shown to be separate from the well-known protein 4.1-dependent interactions of MPP1 with membrane proteins. Furthermore, FLIM analysis revealed that loss of the endogenous MPP1-flotillins interactions resulted in significant changes in RBC membrane-fluidity, emphasizing the physiological importance of such interactions in vivo. Therefore, our data establish a new perspective on the role of MPP1 in erythroid cells and suggests that direct MPP1-flotillins interactions could be the major driving-force behind the formation of raft domains in RBC. Copyright © 2017 The Author(s). Published by Elsevier B.V. All rights reserved.

Solving the Schroedinger equation using the finite difference time domain method

International Nuclear Information System (INIS)

Sudiarta, I Wayan; Geldart, D J Wallace

2007-01-01

In this paper, we solve the Schroedinger equation using the finite difference time domain (FDTD) method to determine energies and eigenfunctions. In order to apply the FDTD method, the Schroedinger equation is first transformed into a diffusion equation by the imaginary time transformation. The resulting time-domain diffusion equation is then solved numerically by the FDTD method. The theory and an algorithm are provided for the procedure. Numerical results are given for illustrative examples in one, two and three dimensions. It is shown that the FDTD method accurately determines eigenfunctions and energies of these systems

Managing Time-Based Conflict Across Life Domains In Nigeria: A ...

African Journals Online (AJOL)

Managing Time-Based Conflict Across Life Domains In Nigeria: A Decision Making Perspective. ... which employees in a developing country attempt to resolve time-based conflict between work, family and other activities. A decision making ...

Subjective time pressure: general or domain specific?

Science.gov (United States)

Kleiner, Sibyl

2014-09-01

Chronic time pressure has been identified as a pervasive societal problem, exacerbated by high demands of the labor market and the home. Yet time pressure has not been disaggregated and examined separately across home and work contexts, leaving many unanswered questions regarding the sources and potentially stressful consequences of time pressure. Using data collected in the United States General Social Survey waves 2002 and 2004, this study disaggregates time pressure into the domains of home and work, and asks whether considering time pressures within distinct work and home contexts reveals distinct predictors or associations with stress. Findings show that both predictors and stress associations differ across work and home pressures, revealing both methodological and theoretical implications for the study of time pressure and work and family life more generally. Copyright © 2014 Elsevier Inc. All rights reserved.

Time domain optical memories using rare earth ions

International Nuclear Information System (INIS)

Sellars, M.J.; Dyke, T.; Pryde, G.J.; Manson, N.B.

1998-01-01

Full text: Rare earth doped crystals are the chosen materials for the next generation of optical memories where the process of spectral holeburning can be employed to provide an extra dimension of frequency or time to spatial dimensions and with certain rare earth ions increases of the order of 10 7 in storage capacity can be achieved over conventional optical memories. Time domain techniques are preferred over frequency domain techniques and are now well developed. In these techniques arbitrary pulse sequences are stored in the material and read out at some later time with a single read pulse using a stimulated photon echo process. Long pulse sequences will enable more data to be stored but necessitates the use of materials with long dephasing times (corresponding to narrow spectral lines) and it is this characteristic of rare earth systems that makes them the preferred material for the new time domain optical memories. The storage time can range from hours to days but in a practical device will require refreshing or re-enforcing and this puts special requirements on the stability of the laser used for storing the information. The storage process itself can also be weak and more reliable storage can be achieved by recording the data several times with the same pulse sequence. For this to be successful the laser must be at held at a constant frequency and be stable in phase over the entire duration of the pulse sequence. The procedure of reinforcing the data sequence has been proposed before and attempted without attention to the laser frequency stability. However, if the laser is not stable although some data bits will be reinforced or increased in size others will be decreased or even erased. Indeed the reliability of the memory is degraded by the introducing the rewrite process. For our work we have developed a laser with the excellent stability and able to demonstrate reproducible reinforcement of the data sequence. Thus with the rewrite sequence we are able to

Electromagnetic Field Theory in (N+1)-Space-Time : AModern Time-Domain Tensor/Array Introduction

NARCIS (Netherlands)

De Hoop, A.T.

2012-01-01

In this paper, a modern time-domain introduction is presented for electromagnetic field theory in (N+1)-spacetime. It uses a consistent tensor/array notation that accommodates the description of electromagnetic phenomena in N-dimensional space (plus time), a requirement that turns up in present-day

Time-domain analysis of frequency dependent inertial wave forces on cylinders

DEFF Research Database (Denmark)

Krenk, Steen

2013-01-01

a simple time-domain procedure for the inertial force, in which the frequency dependence is represented via a simple explicit time filter on the wave particle acceleration or velocity. The frequency dependence of the inertia coefficient is known analytically as a function of the wave......-number, and the relevant range of waves shorter than about six times the diameter typically corresponds to deep water waves. This permits a universal non-dimensional frequency representation, that is converted to rational form to provide the relevant filter equation. Simple time-domain simulations demonstrate...... the reduction of the resonant part of the response for natural structural frequencies above the dominating wave frequency....

Alanine Zipper-Like Coiled-Coil Domains Are Necessary for Homotypic Dimerization of Plant GAGA-Factors in the Nucleus and Nucleolus

Science.gov (United States)

Bloss, Ulrich; Hecker, Andreas; Elgass, Kirstin; Hummel, Sabine; Hahn, Achim; Caesar, Katharina; Schleifenbaum, Frank; Harter, Klaus; Berendzen, Kenneth W.

2011-01-01

GAGA-motif binding proteins control transcriptional activation or repression of homeotic genes. Interestingly, there are no sequence similarities between animal and plant proteins. Plant BBR/BPC-proteins can be classified into two distinct groups: Previous studies have elaborated on group I members only and so little is known about group II proteins. Here, we focused on the initial characterization of AtBPC6, a group II protein from Arabidopsis thaliana. Comparison of orthologous BBR/BPC sequences disclosed two conserved signatures besides the DNA binding domain. A first peptide signature is essential and sufficient to target AtBPC6-GFP to the nucleus and nucleolus. A second domain is predicted to form a zipper-like coiled-coil structure. This novel type of domain is similar to Leucine zippers, but contains invariant alanine residues with a heptad spacing of 7 amino acids. By yeast-2-hybrid and BiFC-assays we could show that this Alanine zipper domain is essential for homotypic dimerization of group II proteins in vivo. Interhelical salt bridges and charge-stabilized hydrogen bonds between acidic and basic residues of the two monomers are predicted to form an interaction domain, which does not follow the classical knobs-into-holes zipper model. FRET-FLIM analysis of GFP/RFP-hybrid fusion proteins validates the formation of parallel dimers in planta. Sequence comparison uncovered that this type of domain is not restricted to BBR/BPC proteins, but is found in all kingdoms. PMID:21347358

Time domain spectroscopy to monitor the condition of cable insulation

International Nuclear Information System (INIS)

Mopsik, F.I.; Martzloff, F.D.

1989-01-01

The use of Time Domain Spectroscopy, the measurement of dielectric constant and loss using time-domain response, the monitoring the aging of reactor cable insulation is examined. The method is presented, showing its sensitivity, accuracy and wide frequency range. The method's ability to acquire a great deal of information in a short time and its superiority to conventional single frequency data is shown. Different cable samples are examined before and after exposure to radiation and changes with exposure are clearly seen to occur. Also it is shown that a wide range of behavior can be found in different insulation systems. The requirements for performing valid measurements is presented. The need for controlled samples and correlation with other criteria for aging is discussed. 14 refs., 9 figs

Perturbative evolution of particle orbits around Kerr black holes: time-domain calculation

Energy Technology Data Exchange (ETDEWEB)

Lopez-Aleman, Ramon [Physical Sciences Department, University of Puerto Rico-Rio Piedras, San Juan, PR 00931 (Puerto Rico); Khanna, Gaurav [Natural Science Division, Long Island University, Southampton, NY 11968 (United States); Pullin, Jorge [Department of Physics and Astronomy, Louisiana State University, 202 Nicholson Hall, Baton Rouge, LA 70803-4001 (United States)

2003-07-21

We consider the problem of the gravitational waves produced by a particle of negligible mass orbiting a Kerr black hole. We treat the Teukolsky perturbation equation in the time domain numerically as a 2 + 1 partial differential equation. We model the particle by smearing the singularities in the source term by the use of narrow Gaussian distributions. We have been able to reproduce earlier results for equatorial circular orbits that were computed using the frequency-domain formalism. The time-domain approach is however geared for a more general evolution, for instance of nearly geodesic orbits under the effects of radiation reaction.

Perturbative evolution of particle orbits around Kerr black holes: time-domain calculation

International Nuclear Information System (INIS)

Lopez-Aleman, Ramon; Khanna, Gaurav; Pullin, Jorge

2003-01-01

We consider the problem of the gravitational waves produced by a particle of negligible mass orbiting a Kerr black hole. We treat the Teukolsky perturbation equation in the time domain numerically as a 2 + 1 partial differential equation. We model the particle by smearing the singularities in the source term by the use of narrow Gaussian distributions. We have been able to reproduce earlier results for equatorial circular orbits that were computed using the frequency-domain formalism. The time-domain approach is however geared for a more general evolution, for instance of nearly geodesic orbits under the effects of radiation reaction

Time-domain analytic Solutions of two-wire transmission line excited by a plane-wave field

Institute of Scientific and Technical Information of China (English)

Ni Gu-Yan; Yan Li; Yuan Nai-Chang

2008-01-01

This paper reports that an analytic method is used to calculate the load responses of the two-wire transmission line excited by a plane-wave directly in the time domain.By the frequency-domain Baum-Liu-Tesche(BLT)equation,the time-domain analytic solutions are obtained and expressed in an infinite geometric series.Moreover,it is shown that there exist only finite nonzero terms in the infinite geometric series if the time variate is at a finite interval.In other word.the time-domain analytic solutions are expanded in a finite geometric series indeed if the time variate is at a finite interval.The computed results are subsequently compared with transient responses obtained by using the frequency-domain BLT equation via a fast Fourier transform,and the agreement is excellent.

Electroporation-Induced Cell Modifications Detected with THz Time-Domain Spectroscopy

Science.gov (United States)

Romeo, Stefania; Vernier, P. Thomas; Zeni, Olga

2018-04-01

Electroporation (electropermeabilization) increases the electrical conductivity of biological cell membranes and lowers transport barriers for normally impermeant materials. Molecular simulations suggest that electroporation begins with the reorganization of water and lipid head group dipoles in the phospholipid bilayer interface, driven by an externally applied electric field, and the evolution of the resulting defects into water-filled, lipid pores. The interior of the electroporated membrane thus contains water, which should provide a signature for detection of the electropermeabilized state. In this feasibility study, we use THz time-domain spectroscopy, a powerful tool for investigating biomolecular systems and their interactions with water, to detect electroporation in human cells subjected to permeabilizing pulsed electric fields (PEFs). The time-domain response of electroporated human monocytes was acquired with a commercial THz, time-domain spectrometer. For each sample, frequency spectra were calculated, and the absorption coefficient and refractive index were extracted in the frequency range between 0.2 and 1.5 THz. This analysis reveals a higher absorption of THz radiation by PEF-exposed cells, with respect to sham-exposed ones, consistent with the intrusion of water into the cell through the permeabilized membrane that is presumed to be associated with electroporation.

Mapping of landfills using time-domain spectral induced polarization data

DEFF Research Database (Denmark)

Gazoty, Aurélie; Fiandaca, Gianluca; Pedersen, Jesper Bjergsted

2012-01-01

This study uses time-domain induced polarization data for the delineation and characterization of the former landfill site at Eskelund, Denmark. With optimized acquisition parameters combined with a new inversion algorithm, we use the full content of the decay curve and retrieve spectral informat......This study uses time-domain induced polarization data for the delineation and characterization of the former landfill site at Eskelund, Denmark. With optimized acquisition parameters combined with a new inversion algorithm, we use the full content of the decay curve and retrieve spectral...... information from time-domain IP data. Thirteen IP/DC profiles were collected in the area, supplemented by el-log drilling for accurate correlation between the geophysics and the lithology. The data were inverted using a laterally constrained 1D inversion considering the full decay curves to retrieve the four......-log measurements giving in situ values, for which the Cole-Cole parameters were computed. The 3D shape of the waste body was pinpointed and well-defined. The inversion of the IP data also shows a strong correlation with the initial stage of the waste dump and its composition combining an aerial map with acquired...

A hybrid time-domain discontinuous galerkin-boundary integral method for electromagnetic scattering analysis

KAUST Repository

Li, Ping; Shi, Yifei; Jiang, Lijun; Bagci, Hakan

2014-01-01

A scheme hybridizing discontinuous Galerkin time-domain (DGTD) and time-domain boundary integral (TDBI) methods for accurately analyzing transient electromagnetic scattering is proposed. Radiation condition is enforced using the numerical flux on the truncation boundary. The fields required by the flux are computed using the TDBI from equivalent currents introduced on a Huygens' surface enclosing the scatterer. The hybrid DGTDBI ensures that the radiation condition is mathematically exact and the resulting computation domain is as small as possible since the truncation boundary conforms to scatterer's shape and is located very close to its surface. Locally truncated domains can also be defined around each disconnected scatterer additionally reducing the size of the overall computation domain. Numerical examples demonstrating the accuracy and versatility of the proposed method are presented. © 2014 IEEE.

A hybrid time-domain discontinuous galerkin-boundary integral method for electromagnetic scattering analysis

KAUST Repository

Li, Ping

2014-05-01

A scheme hybridizing discontinuous Galerkin time-domain (DGTD) and time-domain boundary integral (TDBI) methods for accurately analyzing transient electromagnetic scattering is proposed. Radiation condition is enforced using the numerical flux on the truncation boundary. The fields required by the flux are computed using the TDBI from equivalent currents introduced on a Huygens\\' surface enclosing the scatterer. The hybrid DGTDBI ensures that the radiation condition is mathematically exact and the resulting computation domain is as small as possible since the truncation boundary conforms to scatterer\\'s shape and is located very close to its surface. Locally truncated domains can also be defined around each disconnected scatterer additionally reducing the size of the overall computation domain. Numerical examples demonstrating the accuracy and versatility of the proposed method are presented. © 2014 IEEE.

Time-domain analytic solutions of two-wire transmission line excited by a plane-wave field

International Nuclear Information System (INIS)

Ni Guyan; Yan Li; Yuan Naichang

2008-01-01

This paper reports that an analytic method is used to calculate the load responses of the two-wire transmission line excited by a plane-wave directly in the time domain. By the frequency-domain Baum–Liu–Tesche (BLT) equation, the time-domain analytic solutions are obtained and expressed in an infinite geometric series. Moreover, it is shown that there exist only finite nonzero terms in the infinite geometric series if the time variate is at a finite interval. In other word, the time-domain analytic solutions are expanded in a finite geometric series indeed if the time variate is at a finite interval. The computed results are subsequently compared with transient responses obtained by using the frequency-domain BLT equation via a fast Fourier transform, and the agreement is excellent. (the physics of elementary particles and fields)

Impact of non-white noises in pulse amplitude measurements: a time-domain approach

International Nuclear Information System (INIS)

Pullia, A.

1998-01-01

The contribution of the 1/f-noise to the spectral line broadening in pulse amplitude measurements is derived with a time-domain analysis. The known time-domain relationships which provide the contributions of the series and parallel white noises are generalised for the case of 1/f and other typical non-white noises, by using the fractional derivative of either the system impulse response (time-invariant linear filters) or its weight function folded (time-variant linear filters). It is shown that a time-domain approach is also effective to determine the contribution of Lorentzian noises. A simple rule suitable to derive numerically the fractional derivative is given, which permits to calculate the effect of non-white noises even when the filter impulse response is not known analytically but only in sampled form. (orig.)

An FFT-accelerated time-domain multiconductor transmission line simulator

KAUST Repository

Bagci, Hakan

2010-02-01

A fast time-domain multiconductor transmission line (MTL) simulator for analyzing general MTL networks is presented. The simulator models the networks as homogeneous MTLs that are excited by external fields and driven/terminated/ connected by potentially nonlinear lumped circuitry. It hybridizes an MTL solver derived from time-domain integral equations (TDIEs) in unknown wave coefficients for each MTL with a circuit solver rooted in modified nodal analysis equations in unknown node voltages and voltage-source currents for each circuit. These two solvers are rigorously interfaced at MTL and circuit terminals, and the resulting coupled system of equations is solved simultaneously for all MTL and circuit unknowns at each time step. The proposed simulator is amenable to hybridization, is fast Fourier transform (FFT)-accelerated, and is highly accurate: 1) It can easily be hybridized with TDIE-based field solvers (in a fully rigorous mathematical framework) for performing electromagnetic interference and compatibility analysis on electrically large and complex structures loaded with MTL networks. 2) It is accelerated by an FFT algorithm that calculates temporal convolutions of time-domain MTL Green functions in only O(Ntlog2 N t) rather than O(Ntt2) operations, where N t is the number of time steps of simulation. Moreover, the algorithm, which operates on temporal samples of MTL Green functions, is indifferent to the method used to obtain them. 3) It approximates MTL voltages, currents, and wave coefficients, using high-order temporal basis functions. Various numerical examples, including the crosstalk analysis of a (twisted) unshielded twisted-pair (UTP)-CAT5 cable and the analysis of field coupling into UTP-CAT5 and RG-58 cables located on an airplane, are presented to demonstrate the accuracy, efficiency, and versatility of the proposed simulator. © 2010 IEEE.

An investigation of time-dependent domain wall pinning effects in Tb/Fe multilayer thin flms

NARCIS (Netherlands)

Phillips, G.N.; O'grady, K.; El-Hilo, M.

2002-01-01

Reverse domain nucleation time measurements have been performed on two Tb/Fe multilayer magneto-optic films exhibiting different degrees of domain wall pinning.A linear relationship between ln (reverse domain nucleation time) and the applied field has been predicted and observed for a sample

Multichannel Signal Enhancement using Non-Causal, Time-Domain Filters

DEFF Research Database (Denmark)

Jensen, Jesper Rindom; Christensen, Mads Græsbøll; Benesty, Jacob

2013-01-01

In the vast amount of time-domain filtering methods for speech enhancement, the filters are designed to be causal. Recently, however, it was shown that the noise reduction and signal distortion capabilities of such single-channel filters can be improved by allowing the filters to be non-causal. W......In the vast amount of time-domain filtering methods for speech enhancement, the filters are designed to be causal. Recently, however, it was shown that the noise reduction and signal distortion capabilities of such single-channel filters can be improved by allowing the filters to be non......-causal, multichannel filters for enhancement based on an orthogonal decomposition is proposed. The evaluation shows that there is a potential gain in noise reduction and signal distortion by introducing non-causality. Moreover, experiments on real-life speech show that we can improve the perceptual quality....

Advances in spectral inversion of time-domain induced polarization

DEFF Research Database (Denmark)

Fiandaca, Gianluca; Auken, Esben; Christiansen, Anders Vest

The extraction of spectral information in the inversion process of time-domain (TD) induced polarization (IP) data is changing the use of the TDIP method. Data interpretation is evolving from a qualitative description of the subsurface, able only to discriminate the presence of contrasts in charg......The extraction of spectral information in the inversion process of time-domain (TD) induced polarization (IP) data is changing the use of the TDIP method. Data interpretation is evolving from a qualitative description of the subsurface, able only to discriminate the presence of contrasts...... in chargeability parameters, towards a quantitative analysis of the investigated media, which allows for detailed soil- and rock-type characterization. In this work a review of the recent advances in spectral inversion of TDIP data is presented, in terms of: supported IP parameterizations; modelling of transmitter...

High-Order Calderón Preconditioned Time Domain Integral Equation Solvers

KAUST Repository

Valdes, Felipe; Ghaffari-Miab, Mohsen; Andriulli, Francesco P.; Cools, Kristof; Michielssen,

2013-01-01

Two high-order accurate Calderón preconditioned time domain electric field integral equation (TDEFIE) solvers are presented. In contrast to existing Calderón preconditioned time domain solvers, the proposed preconditioner allows for high-order surface representations and current expansions by using a novel set of fully-localized high-order div-and quasi curl-conforming (DQCC) basis functions. Numerical results demonstrate that the linear systems of equations obtained using the proposed basis functions converge rapidly, regardless of the mesh density and of the order of the current expansion. © 1963-2012 IEEE.

Nonlinear System Identification via Basis Functions Based Time Domain Volterra Model

Directory of Open Access Journals (Sweden)

Yazid Edwar

2014-07-01

Full Text Available This paper proposes basis functions based time domain Volterra model for nonlinear system identification. The Volterra kernels are expanded by using complex exponential basis functions and estimated via genetic algorithm (GA. The accuracy and practicability of the proposed method are then assessed experimentally from a scaled 1:100 model of a prototype truss spar platform. Identification results in time and frequency domain are presented and coherent functions are performed to check the quality of the identification results. It is shown that results between experimental data and proposed method are in good agreement.

High-Order Calderón Preconditioned Time Domain Integral Equation Solvers

KAUST Repository

Valdes, Felipe

2013-05-01

Two high-order accurate Calderón preconditioned time domain electric field integral equation (TDEFIE) solvers are presented. In contrast to existing Calderón preconditioned time domain solvers, the proposed preconditioner allows for high-order surface representations and current expansions by using a novel set of fully-localized high-order div-and quasi curl-conforming (DQCC) basis functions. Numerical results demonstrate that the linear systems of equations obtained using the proposed basis functions converge rapidly, regardless of the mesh density and of the order of the current expansion. © 1963-2012 IEEE.

Introduction to the Finite-Difference Time-Domain (FDTD) Method for Electromagnetics

CERN Document Server

Gedney, Stephen

2011-01-01

Introduction to the Finite-Difference Time-Domain (FDTD) Method for Electromagnetics provides a comprehensive tutorial of the most widely used method for solving Maxwell's equations -- the Finite Difference Time-Domain Method. This book is an essential guide for students, researchers, and professional engineers who want to gain a fundamental knowledge of the FDTD method. It can accompany an undergraduate or entry-level graduate course or be used for self-study. The book provides all the background required to either research or apply the FDTD method for the solution of Maxwell's equations to p

Finite difference time domain modelling of particle accelerators

International Nuclear Information System (INIS)

Jurgens, T.G.; Harfoush, F.A.

1989-03-01

Finite Difference Time Domain (FDTD) modelling has been successfully applied to a wide variety of electromagnetic scattering and interaction problems for many years. Here the method is extended to incorporate the modelling of wake fields in particle accelerators. Algorithmic comparisons are made to existing wake field codes, such as MAFIA T3. 9 refs., 7 figs

Time domain electromagnetic metal detectors

International Nuclear Information System (INIS)

Hoekstra, P.

1996-01-01

This presentation focuses on illustrating by case histories the range of applications and limitations of time domain electromagnetic (TDEM) systems for buried metal detection. Advantages claimed for TDEM metal detectors are: independent of instrument response (Geonics EM61) to surrounding soil and rock type; simple anomaly shape; mitigation of interference by ambient electromagnetic noise; and responsive to both ferrous and non-ferrous metallic targets. The data in all case histories to be presented were acquired with the Geonics EM61 TDEM system. Case histories are a test bed site on Molokai, Hawaii; Fort Monroe, Virginia; and USDOE, Rocky Flats Plant. The present limitations of this technology are: discrimination capabilities in terms of type of ordnance, and depth of burial is limited, and ability of resolving targets with small metallic ambient needs to be improved

Progress in parallel implementation of the multilevel plane wave time domain algorithm

KAUST Repository

Liu, Yang

2013-07-01

The computational complexity and memory requirements of classical schemes for evaluating transient electromagnetic fields produced by Ns dipoles active for Nt time steps scale as O(NtN s 2) and O(Ns 2), respectively. The multilevel plane wave time domain (PWTD) algorithm [A.A. Ergin et al., Antennas and Propagation Magazine, IEEE, vol. 41, pp. 39-52, 1999], viz. the extension of the frequency domain fast multipole method (FMM) to the time domain, reduces the above costs to O(NtNslog2Ns) and O(Ns α) with α = 1.5 for surface current distributions and α = 4/3 for volumetric ones. Its favorable computational and memory costs notwithstanding, serial implementations of the PWTD scheme unfortunately remain somewhat limited in scope and ill-suited to tackle complex real-world scattering problems, and parallel implementations are called for. © 2013 IEEE.

Two-Dimensional Time-Domain Antenna Arrays for Optimum Steerable Energy Pattern with Low Side Lobes

Directory of Open Access Journals (Sweden)

Alberto Reyna

2014-01-01

Full Text Available This document presents the synthesis of different two-dimensional time-domain antenna arrays for steerable energy patterns with side lobe levels. The research is focused on the uniform and nonuniform distributions of true-time exciting delays and positions of antenna elements. The uniform square array, random array, uniform concentric ring array, and rotated nonuniform concentric ring array geometries are particularly studied. These geometries are synthesized by using the well-known sequential quadratic programming. The synthesis regards the optimal true-time exciting delays and optimal positions of pulsed antenna elements. The results show the capabilities of the different antenna arrays to steer the beam in their energy pattern in time domain and how their performance is in frequency domain after the synthesis in time domain.

Quantum-corrected plasmonic field analysis using a time domain PMCHWT integral equation

KAUST Repository

Uysal, Ismail E.

2016-03-13

When two structures are within sub-nanometer distance of each other, quantum tunneling, i.e., electrons "jumping" from one structure to another, becomes relevant. Classical electromagnetic solvers do not directly account for this additional path of current. In this work, an auxiliary tunnel made of Drude material is used to "connect" the structures as a support for this current path (R. Esteban et al., Nat. Commun., 2012). The plasmonic fields on the resulting connected structure are analyzed using a time domain surface integral equation solver. Time domain samples of the dispersive medium Green function and the dielectric permittivities are computed from the analytical inverse Fourier transform applied to the rational function representation of their frequency domain samples.

Comparison between time-and frequency-domain induced polarisation parameters

CSIR Research Space (South Africa)

Van Schoor, Abraham M

2009-09-01

Full Text Available of mineralised rocks and of the contrast between different rock types. It is further shown that a multi-frequency (spectral) approach can be used to avoid this pitfall; similarly, the calculation of different time-domain induced polarisation (IP) parameters...

Dancing with the Electrons: Time-Domain and CW EPR Imaging

Directory of Open Access Journals (Sweden)

Sankaran Subramanian

2008-01-01

Full Text Available The progress in the development of imaging the distribution of unpaired electrons in living systems and the functional and the potential diagnostic dimensions of such an imaging process, using Electron Paramagnetic Resonance Imaging (EPRI, is traced from its origins with emphasis on our own work. The importance of EPR imaging stems from the fact that many paramagnetic probes show oxygen dependent spectral broadening. Assessment of in vivo oxygen concentration is an important factor in radiation oncology in treatment-planning and monitoring treatment-outcome. The emergence of narrow-line trairylmethyl based, bio-compatible spin probes has enabled the development of radiofrequency time-domain EPRI. Spectral information in time-domain EPRI can be achieved by generating a time sequence of T 2 * or T 2 weighted images. Progress in CW imaging has led to the use of rotating gradients, more recently rapid scan with direct detection, and a combination of all the three. Very low field MRI employing Dynamic Nuclear polarization (Overhauser effect is also employed for monitoring tumor hypoxia, and re-oxygenation in vivo . We have also been working on the co-registration of MRI and time domain EPRI on mouse tumor models at 300 MHz using a specially designed resonator assembly. The mapping of the unpaired electron distribution and unraveling the spectral characteristics by using magnetic resonance in presence of stationary and rotating gradients in indeed ‘dancing with the ( unpaired electrons’, metaphorically speaking.

A space-time mixed galerkin marching-on-in-time scheme for the time-domain combined field integral equation

KAUST Repository

Beghein, Yves

2013-03-01

The time domain combined field integral equation (TD-CFIE), which is constructed from a weighted sum of the time domain electric and magnetic field integral equations (TD-EFIE and TD-MFIE) for analyzing transient scattering from closed perfect electrically conducting bodies, is free from spurious resonances. The standard marching-on-in-time technique for discretizing the TD-CFIE uses Galerkin and collocation schemes in space and time, respectively. Unfortunately, the standard scheme is theoretically not well understood: stability and convergence have been proven for only one class of space-time Galerkin discretizations. Moreover, existing discretization schemes are nonconforming, i.e., the TD-MFIE contribution is tested with divergence conforming functions instead of curl conforming functions. We therefore introduce a novel space-time mixed Galerkin discretization for the TD-CFIE. A family of temporal basis and testing functions with arbitrary order is introduced. It is explained how the corresponding interactions can be computed efficiently by existing collocation-in-time codes. The spatial mixed discretization is made fully conforming and consistent by leveraging both Rao-Wilton-Glisson and Buffa-Christiansen basis functions and by applying the appropriate bi-orthogonalization procedures. The combination of both techniques is essential when high accuracy over a broad frequency band is required. © 2012 IEEE.

Windowing of THz time-domain spectroscopy signals: A study based on lactose

Science.gov (United States)

Vázquez-Cabo, José; Chamorro-Posada, Pedro; Fraile-Peláez, Francisco Javier; Rubiños-López, Óscar; López-Santos, José María; Martín-Ramos, Pablo

2016-05-01

Time-domain spectroscopy has established itself as a reference method for determining material parameters in the terahertz spectral range. This procedure requires the processing of the measured time-domain signals in order to estimate the spectral data. In this work, we present a thorough study of the properties of the signal windowing, a step previous to the parameter extraction algorithm, that permits to improve the accuracy of the results. Lactose has been used as sample material in the study.

Nonlinear behavior in the time domain in argon atmospheric dielectric-barrier discharges

International Nuclear Information System (INIS)

Shi Hong; Wang Yanhui; Wang Dezhen

2008-01-01

A vast majority of nonlinear behavior in atmospheric pressure discharges has so far been studied in the space domain, and their time-domain characters are often believed to exact the periodicity of the externally applied voltage. In this paper, based on one-dimensional fluid mode, we study complex nonlinear behavior in the time domain in argon atmospheric dielectric-barrier discharges at very broad frequency range from kilohertz to megahertz. Under certain conditions, the discharge not only can be driven to chaos from time-periodic state through period-doubling bifurcation, but also can return stable periodic motion from chaotic state through an inverse period-doubling bifurcation sequence. Upon changing the parameter the discharge undergoes alternatively chaotic and periodic behavior. Some periodic windows embedded in chaos, as well as the secondary bifurcation occurring in the periodic windows can also be observed. The corresponding discharge characteristics are investigated.

The time domain triple probe method

International Nuclear Information System (INIS)

Meier, M.A.; Hallock, G.A.; Tsui, H.Y.W.; Bengtson, R.D.

1994-01-01

A new Langmuir probe technique based on the triple probe method is being developed to provide simultaneous measurement of plasma temperature, potential, and density with the temporal and spatial resolution required to accurately characterize plasma turbulence. When the conventional triple probe method is used in an inhomogeneous plasma, local differences in the plasma measured at each probe introduce significant error in the estimation of turbulence parameters. The Time Domain Triple Probe method (TDTP) uses high speed switching of Langmuir probe potential, rather than spatially separated probes, to gather the triple probe information thus avoiding these errors. Analysis indicates that plasma response times and recent electronics technology meet the requirements to implement the TDTP method. Data reduction techniques of TDTP data are to include linear and higher order correlation analysis to estimate fluctuation induced particle and thermal transport, as well as energy relationships between temperature, density, and potential fluctuations

Domain-Generality of Timing-Based Serial Order Processes in Short-Term Memory: New Insights from Musical and Verbal Domains.

Directory of Open Access Journals (Sweden)

Simon Gorin

Full Text Available Several models in the verbal domain of short-term memory (STM consider a dissociation between item and order processing. This view is supported by data demonstrating that different types of time-based interference have a greater effect on memory for the order of to-be-remembered items than on memory for the items themselves. The present study investigated the domain-generality of the item versus serial order dissociation by comparing the differential effects of time-based interfering tasks, such as rhythmic interference and articulatory suppression, on item and order processing in verbal and musical STM domains. In Experiment 1, participants had to maintain sequences of verbal or musical information in STM, followed by a probe sequence, this under different conditions of interference (no-interference, rhythmic interference, articulatory suppression. They were required to decide whether all items of the probe list matched those of the memory list (item condition or whether the order of the items in the probe sequence matched the order in the memory list (order condition. In Experiment 2, participants performed a serial order probe recognition task for verbal and musical sequences ensuring sequential maintenance processes, under no-interference or rhythmic interference conditions. For Experiment 1, serial order recognition was not significantly more impacted by interfering tasks than was item recognition, this for both verbal and musical domains. For Experiment 2, we observed selective interference of the rhythmic interference condition on both musical and verbal order STM tasks. Overall, the results suggest a similar and selective sensitivity to time-based interference for serial order STM in verbal and musical domains, but only when the STM tasks ensure sequential maintenance processes.

Domain-Generality of Timing-Based Serial Order Processes in Short-Term Memory: New Insights from Musical and Verbal Domains.

Science.gov (United States)

Gorin, Simon; Kowialiewski, Benjamin; Majerus, Steve

2016-01-01

Several models in the verbal domain of short-term memory (STM) consider a dissociation between item and order processing. This view is supported by data demonstrating that different types of time-based interference have a greater effect on memory for the order of to-be-remembered items than on memory for the items themselves. The present study investigated the domain-generality of the item versus serial order dissociation by comparing the differential effects of time-based interfering tasks, such as rhythmic interference and articulatory suppression, on item and order processing in verbal and musical STM domains. In Experiment 1, participants had to maintain sequences of verbal or musical information in STM, followed by a probe sequence, this under different conditions of interference (no-interference, rhythmic interference, articulatory suppression). They were required to decide whether all items of the probe list matched those of the memory list (item condition) or whether the order of the items in the probe sequence matched the order in the memory list (order condition). In Experiment 2, participants performed a serial order probe recognition task for verbal and musical sequences ensuring sequential maintenance processes, under no-interference or rhythmic interference conditions. For Experiment 1, serial order recognition was not significantly more impacted by interfering tasks than was item recognition, this for both verbal and musical domains. For Experiment 2, we observed selective interference of the rhythmic interference condition on both musical and verbal order STM tasks. Overall, the results suggest a similar and selective sensitivity to time-based interference for serial order STM in verbal and musical domains, but only when the STM tasks ensure sequential maintenance processes.

Common-image gathers in the offset domain from reverse-time migration

KAUST Repository

Zhan, Ge

2014-04-01

Kirchhoff migration is flexible to output common-image gathers (CIGs) in the offset domain by imaging data with different offsets separately. These CIGs supply important information for velocity model updates and amplitude-variation-with-offset (AVO) analysis. Reverse-time migration (RTM) offers more insights into complex geology than Kirchhoff migration by accurately describing wave propagation using the two-way wave equation. But, it has difficulty to produce offset domain CIGs like Kirchhoff migration. In this paper, we develop a method for obtaining offset domain CIGs from RTM. The method first computes the RTM operator of an offset gather, followed by a dot product of the operator and the offset data to form a common-offset RTM image. The offset domain CIGs are then achieved after separately migrating data with different offsets. We generate offset domain CIGs on both the Marmousi synthetic data and 2D Gulf of Mexico real data using this approach. © 2014.

Time-Domain Diversity in Ultra-Wideband MIMO Communications

Directory of Open Access Journals (Sweden)

Alain Sibille

2005-03-01

Full Text Available The development of ultra-wideband (UWB communications is impeded by the drastic transmitted power limitations imposed by regulation authorities due to the “polluting” character of these radio emissions with respect to existing services. Technical solutions must be researched in order either to limit the level of spectral pollution by UWB devices or to increase their reception sensitivity. In the present work, we consider pulse-based modulations and investigate time-domain multiple-input multiple-output (MIMO diversity as one such possible solution. The basic principles of time-domain diversity in the extreme (low multipath density or intermediate (dense multipath UWB regimes are addressed, which predict the possibility of a MIMO gain equal to the product Nt×Nr of the numbers of transmit/receive antenna elements when the channel is not too severe. This analysis is confirmed by simulations using a parametric empirical stochastic double-directional channel model. They confirm the potential interest of MIMO approaches solutions in order to bring a valuable performance gain in UWB communications.

A pseudospectral collocation time-domain method for diffractive optics

DEFF Research Database (Denmark)

Dinesen, P.G.; Hesthaven, J.S.; Lynov, Jens-Peter

2000-01-01

We present a pseudospectral method for the analysis of diffractive optical elements. The method computes a direct time-domain solution of Maxwell's equations and is applied to solving wave propagation in 2D diffractive optical elements. (C) 2000 IMACS. Published by Elsevier Science B.V. All rights...

Time-domain single-source integral equations for analyzing scattering from homogeneous penetrable objects

KAUST Repository

Valdés, Felipe

2013-03-01

Single-source time-domain electric-and magnetic-field integral equations for analyzing scattering from homogeneous penetrable objects are presented. Their temporal discretization is effected by using shifted piecewise polynomial temporal basis functions and a collocation testing procedure, thus allowing for a marching-on-in-time (MOT) solution scheme. Unlike dual-source formulations, single-source equations involve space-time domain operator products, for which spatial discretization techniques developed for standalone operators do not apply. Here, the spatial discretization of the single-source time-domain integral equations is achieved by using the high-order divergence-conforming basis functions developed by Graglia alongside the high-order divergence-and quasi curl-conforming (DQCC) basis functions of Valdés The combination of these two sets allows for a well-conditioned mapping from div-to curl-conforming function spaces that fully respects the space-mapping properties of the space-time operators involved. Numerical results corroborate the fact that the proposed procedure guarantees accuracy and stability of the MOT scheme. © 2012 IEEE.

Measurement of electron paramagnetic resonance using terahertz time-domain spectroscopy.

Science.gov (United States)

Kozuki, Kohei; Nagashima, Takeshi; Hangyo, Masanori

2011-12-05

We present a frequency-domain electron spin resonance (ESR) measurement system using terahertz time-domain spectroscopy. A crossed polarizer technique is utilized to increase the sensitivity in detecting weak ESR signals of paramagnets caused by magnetic dipole transitions between magnetic sublevels. We demonstrate the measurements of ESR signal of paramagnetic copper(II) sulfate pentahydrate with uniaxial anisotropy of the g-factor under magnetic fields up to 10 T. The lineshape of the obtained ESR signals agrees well with the theoretical predictions for a powder sample with the uniaxial anisotropy.

Reduction of Poisson noise in measured time-resolved data for time-domain diffuse optical tomography.

Science.gov (United States)

Okawa, S; Endo, Y; Hoshi, Y; Yamada, Y

2012-01-01

A method to reduce noise for time-domain diffuse optical tomography (DOT) is proposed. Poisson noise which contaminates time-resolved photon counting data is reduced by use of maximum a posteriori estimation. The noise-free data are modeled as a Markov random process, and the measured time-resolved data are assumed as Poisson distributed random variables. The posterior probability of the occurrence of the noise-free data is formulated. By maximizing the probability, the noise-free data are estimated, and the Poisson noise is reduced as a result. The performances of the Poisson noise reduction are demonstrated in some experiments of the image reconstruction of time-domain DOT. In simulations, the proposed method reduces the relative error between the noise-free and noisy data to about one thirtieth, and the reconstructed DOT image was smoothed by the proposed noise reduction. The variance of the reconstructed absorption coefficients decreased by 22% in a phantom experiment. The quality of DOT, which can be applied to breast cancer screening etc., is improved by the proposed noise reduction.

Quantitative FLIM-FRET Microscopy to Monitor Nanoscale Chromatin Compaction In Vivo Reveals Structural Roles of Condensin Complexes

Directory of Open Access Journals (Sweden)

David Llères

2017-02-01

Full Text Available How metazoan genomes are structured at the nanoscale in living cells and tissues remains unknown. Here, we adapted a quantitative FRET (Förster resonance energy transfer-based fluorescence lifetime imaging microscopy (FLIM approach to assay nanoscale chromatin compaction in living organisms. Caenorhabditis elegans was chosen as a model system. By measuring FRET between histone-tagged fluorescent proteins, we visualized distinct chromosomal regions and quantified the different levels of nanoscale compaction in meiotic cells. Using RNAi and repetitive extrachromosomal array approaches, we defined the heterochromatin state and showed that its architecture presents a nanoscale-compacted organization controlled by Heterochromatin Protein-1 (HP1 and SETDB1 H3-lysine-9 methyltransferase homologs in vivo. Next, we functionally explored condensin complexes. We found that condensin I and condensin II are essential for heterochromatin compaction and that condensin I additionally controls lowly compacted regions. Our data show that, in living animals, nanoscale chromatin compaction is controlled not only by histone modifiers and readers but also by condensin complexes.

Quasi-exact evaluation of time domain MFIE MOT matrix elements

KAUST Repository

Shi, Yifei; Bagci, Hakan; Shanker, Balasubramaniam; Lu, Mingyu; Michielssen, Eric

2013-01-01

A previously proposed quasi-exact scheme for evaluating matrix elements resulting from the marching-on-in-time (MOT) discretization of the time domain electric field integral equation (EFIE) is extended to matrix entries resulting from the discretization of its magnetic field integral equation (MFIE) counterpart. Numerical results demonstrate the accuracy of the scheme as well as the late-time stability of the resulting MOT-MFIE solver. © 2013 IEEE.

Quasi-exact evaluation of time domain MFIE MOT matrix elements

KAUST Repository

Shi, Yifei

2013-07-01

A previously proposed quasi-exact scheme for evaluating matrix elements resulting from the marching-on-in-time (MOT) discretization of the time domain electric field integral equation (EFIE) is extended to matrix entries resulting from the discretization of its magnetic field integral equation (MFIE) counterpart. Numerical results demonstrate the accuracy of the scheme as well as the late-time stability of the resulting MOT-MFIE solver. © 2013 IEEE.

Joint time-frequency domain proportional fair scheduler with HARQ for 3GPP LTE systems

OpenAIRE

Beh, KC; Doufexi, A; Armour, SMD

2008-01-01

This paper explores the potential gain of joint diversity in both frequency domain and time domain which can be exploited to achieve spectral efficiency gains whilst simultaneously facilitating QoS/ fairness in an OFDMA system particularly in 3GPP Long Term Evolution (LTE)). The performance of several joint time-frequency schedulers is investigated. Simulation results show that joint time frequency schedulers achieve significantly superior performance compared to a more conventional time doma...

Spectral phase encoding of ultra-short optical pulse in time domain for OCDMA application.

Science.gov (United States)

Wang, Xu; Wada, Naoya

2007-06-11

We propose a novel reconfigurable time domain spectral phase encoding (SPE) scheme for coherent optical code-division-multiple-access application. In the proposed scheme, the ultra-short optical pulse is stretched by dispersive device and the SPE is done in time domain using high speed phase modulator. The time domain SPE scheme is robust to wavelength drift of the light source and is very flexible and compatible with the fiber optical system. Proof-of-principle experiments of encoding with 16-chip, 20 GHz/chip binary-phase-shift-keying codes and 1.25 Gbps data transmission have been successfully demonstrated together with an arrayed-wave-guide decoder.

Finite-difference time-domain simulation of thermal noise in open cavities

International Nuclear Information System (INIS)

Andreasen, Jonathan; Cao Hui; Taflove, Allen; Kumar, Prem; Cao Changqi

2008-01-01

A numerical model based on the finite-difference time-domain (FDTD) method is developed to simulate thermal noise in open cavities owing to output coupling. The absorbing boundary of the FDTD grid is treated as a blackbody, whose thermal radiation penetrates the cavity in the grid. The calculated amount of thermal noise in a one-dimensional dielectric cavity recovers the standard result of the quantum Langevin equation in the Markovian regime. Our FDTD simulation also demonstrates that in the non-Markovian regime the buildup of the intracavity noise field depends on the ratio of the cavity photon lifetime to the coherence time of thermal radiation. The advantage of our numerical method is that the thermal noise is introduced in the time domain without prior knowledge of cavity modes

Efficient reconstruction of dispersive dielectric profiles using time domain reflectometry (TDR

Directory of Open Access Journals (Sweden)

P. Leidenberger

2006-01-01

Full Text Available We present a numerical model for time domain reflectometry (TDR signal propagation in dispersive dielectric materials. The numerical probe model is terminated with a parallel circuit, consisting of an ohmic resistor and an ideal capacitance. We derive analytical approximations for the capacitance, the inductance and the conductance of three-wire probes. We couple the time domain model with global optimization in order to reconstruct water content profiles from TDR traces. For efficiently solving the inverse problem we use genetic algorithms combined with a hierarchical parameterization. We investigate the performance of the method by reconstructing synthetically generated profiles. The algorithm is then applied to retrieve dielectric profiles from TDR traces measured in the field. We succeed in reconstructing dielectric and ohmic profiles where conventional methods, based on travel time extraction, fail.

Ultrabroadband THz time-domain spectroscopy of biomolecular crystals

DEFF Research Database (Denmark)

Kaltenecker, Korbinian J.; Engelbrecht, Sebastian; Iwaszczuk, Krzysztof

2016-01-01

Ultrabroadband THz time-domain spectroscopy based on two-color plasma generation and air biased coherent detection is used for the investigation of molecular dynamics of crystalline materials in the frequency range from 0.3 THz to 20 THz. We show that the spectral features in this extended...... frequency range are a result of inter- and intramolecular vibrations which are identified by means of simulations of the crystalline materials....

Numerical results for near surface time domain electromagnetic exploration: a full waveform approach

Science.gov (United States)

Sun, H.; Li, K.; Li, X., Sr.; Liu, Y., Sr.; Wen, J., Sr.

2015-12-01

Time domain or Transient electromagnetic (TEM) survey including types with airborne, semi-airborne and ground play important roles in applicants such as geological surveys, ground water/aquifer assess [Meju et al., 2000; Cox et al., 2010], metal ore exploration [Yang and Oldenburg, 2012], prediction of water bearing structures in tunnels [Xue et al., 2007; Sun et al., 2012], UXO exploration [Pasion et al., 2007; Gasperikova et al., 2009] etc. The common practice is introducing a current into a transmitting (Tx) loop and acquire the induced electromagnetic field after the current is cut off [Zhdanov and Keller, 1994]. The current waveforms are different depending on instruments. Rectangle is the most widely used excitation current source especially in ground TEM. Triangle and half sine are commonly used in airborne and semi-airborne TEM investigation. In most instruments, only the off time responses are acquired and used in later analysis and data inversion. Very few airborne instruments acquire the on time and off time responses together. Although these systems acquire the on time data, they usually do not use them in the interpretation.This abstract shows a novel full waveform time domain electromagnetic method and our recent modeling results. The benefits comes from our new algorithm in modeling full waveform time domain electromagnetic problems. We introduced the current density into the Maxwell's equation as the transmitting source. This approach allows arbitrary waveforms, such as triangle, half-sine, trapezoidal waves or scatter record from equipment, being used in modeling. Here, we simulate the establishing and induced diffusion process of the electromagnetic field in the earth. The traditional time domain electromagnetic with pure secondary fields can also be extracted from our modeling results. The real time responses excited by a loop source can be calculated using the algorithm. We analyze the full time gates responses of homogeneous half space and two

On spurious resonant modes in the MOT solution of time domain EFIE

KAUST Repository

Shi, Yifei; Bagci, Hakan; Lu, Mingyu

2013-01-01

Theoretically, internal resonant modes should not be induced in the marching-on-in-time (MOT) solution of the time domain electric field integral equation since zero initial conditions are enforced at the beginning of time marching and the internal

Time-resolved magnetization dynamics of cross-tie domain walls in permalloy microstructures

International Nuclear Information System (INIS)

Miguel, J; Kurde, J; Piantek, M; Kuch, W; Sanchez-Barriga, J; Heitkamp, B; Kronast, F; Duerr, H A; Bayer, D; Aeschlimann, M

2009-01-01

We report on a picosecond time-resolved x-ray magnetic circular dichroic-photoelectron emission microscopy study of the evolution of the magnetization components of a microstructured permalloy platelet comprising three cross-tie domain walls. A laser-excited photoswitch has been used to apply a triangular 80 Oe, 160 ps magnetic pulse. Micromagnetic calculations agree well with the experimental results, both in time and frequency, illustrating the large angle precession in the magnetic domains with magnetization perpendicular to the applied pulse, and showing how the magnetic vortices revert their core magnetization while the antivortices remain unaffected.

Time-resolved magnetization dynamics of cross-tie domain walls in permalloy microstructures

Energy Technology Data Exchange (ETDEWEB)

Miguel, J; Kurde, J; Piantek, M; Kuch, W [Institut fuer Experimentalphysik, Freie Universitaet Berlin, Arnimallee 14, D-14195 Berlin (Germany); Sanchez-Barriga, J; Heitkamp, B; Kronast, F; Duerr, H A [Helmholtz-Zentrum Berlin fuer Materialien und Energie, Elektronenspeicherring BESSY II, Albert-Einstein-Strasse 15, D-12489 Berlin (Germany); Bayer, D; Aeschlimann, M, E-mail: jorge.miguel@fu-berlin.d [Fachbereich Physik, Universitaet Kaiserslautern, Erwin-Schroedinger Strasse 46, D-67663 Kaiserslautern (Germany)

2009-12-02

We report on a picosecond time-resolved x-ray magnetic circular dichroic-photoelectron emission microscopy study of the evolution of the magnetization components of a microstructured permalloy platelet comprising three cross-tie domain walls. A laser-excited photoswitch has been used to apply a triangular 80 Oe, 160 ps magnetic pulse. Micromagnetic calculations agree well with the experimental results, both in time and frequency, illustrating the large angle precession in the magnetic domains with magnetization perpendicular to the applied pulse, and showing how the magnetic vortices revert their core magnetization while the antivortices remain unaffected.

In vivo detection of oral epithelial cancer using endogenous fluorescence lifetime imaging: a pilot human study (Conference Presentation)

Science.gov (United States)

Jo, Javier A.; Hwang, Dae Yon; Palma, Jorge; Cheng, Shuna; Cuenca, Rodrigo; Malik, Bilal; Jabbour, Joey; Cheng, Lisa; Wright, John; Maitland, Kristen

2016-03-01

Endogenous fluorescence lifetime imaging (FLIM) provides direct access to the concomitant functional and biochemical changes accompanying tissue transition from benign to precancerous and cancerous. Since FLIM can noninvasively measure different and complementary biomarkers of precancer and cancer, we hypothesize that it will aid in clinically detecting early oral epithelial cancer. Our group has recently demonstrated the detection of benign from premalignant and malignant lesions based on endogenous multispectral FLIM in the hamster cheek-pouch model. Encouraged by these positive preliminary results, we have developed a handheld endoscope capable of acquiring multispectral FLIM images in real time from the oral mucosa. This novel FLIM endoscope is being used for imaging clinically suspicious pre-malignant and malignant lesions from patients before undergoing tissue biopsy for histopathological diagnosis of oral epithelial cancer. Our preliminary results thus far are already suggesting the potential of endogenous FLIM for distinguishing a variety of benign lesions from advanced dysplasia and squamous cell carcinoma (SCC). To the best of out knowledge, this is the first in vivo human study aiming to demonstrate the ability to predict the true malignancy of clinically suspicious lesions using endogenous FLIM. If successful, the resulting clinical tool will allow noninvasive real-time detection of epithelial precancerous and cancerous lesions in the oral mucosa and could potentially be used to assist at every step involved on the clinical management of oral cancer patients, from early screening and diagnosis, to treatment and monitoring of recurrence.

Time-Domain Analytical Expression for Near Fields of Arbitrarily Oriented Electric Dipole and Its Application

Directory of Open Access Journals (Sweden)

Qian Yang

2017-01-01

Full Text Available The near fields of electric dipole are commonly used in wide-band analysis of complex electromagnetic problems. In this paper, we propose new near field time-domain expressions for electric dipole. The analytical expressions for the frequency-domain of arbitrarily oriented electric dipole are given at first; next we give the time-domain expressions by time-frequency transformation. The proposed expressions are used in hybrid TDIE/DGTD method for analysis of circular antenna with radome. The accuracy of the proposed algorithm is verified by numerical examples.

THE PSTD ALGORITHM: A TIME-DOMAIN METHOD REQUIRING ONLY TWO CELLS PER WAVELENGTH. (R825225)

Science.gov (United States)

A pseudospectral time-domain (PSTD) method is developed for solutions of Maxwell's equations. It uses the fast Fourier transform (FFT), instead of finite differences on conventional finite-difference-time-domain (FDTD) methods, to represent spatial derivatives. Because the Fourie...

The Simulation Realization of Pavement Roughness in the Time Domain

Science.gov (United States)

XU, H. L.; He, L.; An, D.

2017-10-01

As the needs for the dynamic study on the vehicle-pavement system and the simulated vibration table test, how to simulate the pavement roughness actually is important guarantee for whether calculation and test can reflect the actual situation or not. Using the power spectral density function, the simulation of pavement roughness can be realized by Fourier inverse transform. The main idea of this method was that the spectrum amplitude and random phase were obtained separately according to the power spectrum, and then the simulation of pavement roughness was obtained in the time domain through the Fourier inverse transform (IFFT). In the process, the sampling interval (Δl) was 0.1m, and the sampling points(N) was 4096, which satisfied the accuracy requirements. Using this method, the simulate results of pavement roughness (A~H grades) were obtain in the time domain.

A discontinuous galerkin time domain-boundary integral method for analyzing transient electromagnetic scattering

KAUST Repository

Li, Ping

2014-07-01

This paper presents an algorithm hybridizing discontinuous Galerkin time domain (DGTD) method and time domain boundary integral (BI) algorithm for 3-D open region electromagnetic scattering analysis. The computational domain of DGTD is rigorously truncated by analytically evaluating the incoming numerical flux from the outside of the truncation boundary through BI method based on the Huygens\\' principle. The advantages of the proposed method are that it allows the truncation boundary to be conformal to arbitrary (convex/ concave) scattering objects, well-separated scatters can be truncated by their local meshes without losing the physics (such as coupling/multiple scattering) of the problem, thus reducing the total mesh elements. Furthermore, low frequency waves can be efficiently absorbed, and the field outside the truncation domain can be conveniently calculated using the same BI formulation. Numerical examples are benchmarked to demonstrate the accuracy and versatility of the proposed method.

Numerical modeling of time domain 3-D problems in accelerator physics

International Nuclear Information System (INIS)

Harfoush, F.A.; Jurgens, T.G.

1990-06-01

Time domain analysis is relevant in particle accelerators to study the electromagnetic field interaction of a moving source particle on a lagging test particle as the particles pass an accelerating cavity or some other structure. These fields are called wake fields. The travelling beam inside a beam pipe may undergo more complicated interactions with its environment due to the presence of other irregularities like wires, thin slots, joints and other types of obstacles. Analytical solutions of such problems is impossible and one has to resort to a numerical method. In this paper we present results of our first attempt to model these problems in 3-D using our finite difference time domain (FDTD) code. 10 refs., 9 figs

On the initial condition problem of the time domain PMCHWT surface integral equation

KAUST Repository

Uysal, Ismail Enes

2017-05-13

Non-physical, linearly increasing and constant current components are induced in marching on-in-time solution of time domain surface integral equations when initial conditions on time derivatives of (unknown) equivalent currents are not enforced properly. This problem can be remedied by solving the time integral of the surface integral for auxiliary currents that are defined to be the time derivatives of the equivalent currents. Then the equivalent currents are obtained by numerically differentiating the auxiliary ones. In this work, this approach is applied to the marching on-in-time solution of the time domain Poggio-Miller-Chan-Harrington-Wu-Tsai surface integral equation enforced on dispersive/plasmonic scatterers. Accuracy of the proposed method is demonstrated by a numerical example.

Time domain NMR evaluation of poly(vinyl alcohol) xerogels

Energy Technology Data Exchange (ETDEWEB)

Rodrigues, Elton Jorge da Rocha; Cavalcante, Maxwell de Paula; Tavares, Maria Ines Bruno, E-mail: mibt@ima.ufrj.br [Universidade Federal do Rio de Janeiro (IMA/UFRJ), Rio de Janeiro, RJ (Brazil). Centro de Tecnologia. Instituto de Macromoleculas Professora Eloisa Mano

2016-05-15

Poly(vinyl alcohol) (PVA)-based chemically cross-linked xerogels, both neat and loaded with nanoparticulate hydrophilic silica (SiO{sub 2}), were obtained and characterized mainly through time domain NMR experiments (TD-NMR). Fourier-transform infrared (FT-IR) and wide angle X-ray diffraction (WAXD) analyses were employed as secondary methods. TD-NMR, through the interpretation of the spin-lattice relaxation constant values and related information, showed both cross-linking and nanoparticle influences on PVA matrix. SiO{sub 2} does not interact chemically with the PVA chains, but has effect on its molecular mobility, as investigated via TD-NMR. Apparent energy of activation, spin-lattice time constant and size of spin domains in the sample have almost linear dependence with the degree of cross-linking of the PVA and are affected by the addition of SiO{sub 2}. These three parameters were derived from a single set of TD-NMR experiments, which demonstrates the versatility of the technique for characterization of inorganic-organic hybrid xerogels, an important class of materials. (author)

Time Domains of the Hypoxic Ventilatory Response and Their Molecular Basis

Science.gov (United States)

Pamenter, Matthew E.; Powell, Frank L.

2016-01-01

Ventilatory responses to hypoxia vary widely depending on the pattern and length of hypoxic exposure. Acute, prolonged, or intermittent hypoxic episodes can increase or decrease breathing for seconds to years, both during the hypoxic stimulus, and also after its removal. These myriad effects are the result of a complicated web of molecular interactions that underlie plasticity in the respiratory control reflex circuits and ultimately control the physiology of breathing in hypoxia. Since the time domains of the physiological hypoxic ventilatory response (HVR) were identified, considerable research effort has gone toward elucidating the underlying molecular mechanisms that mediate these varied responses. This research has begun to describe complicated and plastic interactions in the relay circuits between the peripheral chemoreceptors and the ventilatory control circuits within the central nervous system. Intriguingly, many of these molecular pathways seem to share key components between the different time domains, suggesting that varied physiological HVRs are the result of specific modifications to overlapping pathways. This review highlights what has been discovered regarding the cell and molecular level control of the time domains of the HVR, and highlights key areas where further research is required. Understanding the molecular control of ventilation in hypoxia has important implications for basic physiology and is emerging as an important component of several clinical fields. PMID:27347896

Gravitational Waves and Time Domain Astronomy

Science.gov (United States)

Centrella, Joan; Nissanke, Samaya; Williams, Roy

2012-01-01

The gravitational wave window onto the universe will open in roughly five years, when Advanced LIGO and Virgo achieve the first detections of high frequency gravitational waves, most likely coming from compact binary mergers. Electromagnetic follow-up of these triggers, using radio, optical, and high energy telescopes, promises exciting opportunities in multi-messenger time domain astronomy. In the decade, space-based observations of low frequency gravitational waves from massive black hole mergers, and their electromagnetic counterparts, will open up further vistas for discovery. This two-part workshop featured brief presentations and stimulating discussions on the challenges and opportunities presented by gravitational wave astronomy. Highlights from the workshop, with the emphasis on strategies for electromagnetic follow-up, are presented in this report.

Comparison of Cole-Cole and Constant Phase Angle modeling in time-domain induced polarization

DEFF Research Database (Denmark)

Lajaunie, Myriam; Maurya, Pradip Kumar; Fiandaca, Gianluca

The Cole-Cole model and the constant phase angle (CPA) model are two prevailing phenomenological descriptions of the induced polarization (IP), used for both frequency domain (FD) and time domain (TD) modeling. The former one is a 4-parameter description, while the latest one involves only two......, forward modeling of quadrupolar sequences on 1D and 2D heterogeneous CPA models shows that the CPA decays differ among each other only by a multiplication factor. Consequently, the inspection of field data in log-log plots gives insight on the modeling needed for fitting them: the CPA inversion cannot...... is reflected in TDIP data, and therefore, at identifying (1) if and when it is possible to distinguish, in time domain, between a Cole-Cole description and a CPA one, and (2) if features of time domain data exist in order to know, from a simple data inspection, which model will be the most adapted to the data...

Perceived Interpersonal Discrimination and Older Women’s Mental Health: Accumulation Across Domains, Attributions, and Time

Science.gov (United States)

Bécares, Laia; Zhang, Nan

2018-01-01

Abstract Experiencing discrimination is associated with poor mental health, but how cumulative experiences of perceived interpersonal discrimination across attributes, domains, and time are associated with mental disorders is still unknown. Using data from the Study of Women’s Health Across the Nation (1996–2008), we applied latent class analysis and generalized linear models to estimate the association between cumulative exposure to perceived interpersonal discrimination and older women’s mental health. We found 4 classes of perceived interpersonal discrimination, ranging from cumulative exposure to discrimination over attributes, domains, and time to none or minimal reports of discrimination. Women who experienced cumulative perceived interpersonal discrimination over time and across attributes and domains had the highest risk of depression (Center for Epidemiologic Studies Depression Scale score ≥16) compared with women in all other classes. This was true for all women regardless of race/ethnicity, although the type and severity of perceived discrimination differed across racial/ethnic groups. Cumulative exposure to perceived interpersonal discrimination across attributes, domains, and time has an incremental negative long-term association with mental health. Studies that examine exposure to perceived discrimination due to a single attribute in 1 domain or at 1 point in time underestimate the magnitude and complexity of discrimination and its association with health. PMID:29036550

New Flutter Analysis Technique for Time-Domain Computational Aeroelasticity

Science.gov (United States)

Pak, Chan-Gi; Lung, Shun-Fat

2017-01-01

A new time-domain approach for computing flutter speed is presented. Based on the time-history result of aeroelastic simulation, the unknown unsteady aerodynamics model is estimated using a system identification technique. The full aeroelastic model is generated via coupling the estimated unsteady aerodynamic model with the known linear structure model. The critical dynamic pressure is computed and used in the subsequent simulation until the convergence of the critical dynamic pressure is achieved. The proposed method is applied to a benchmark cantilevered rectangular wing.

Development and application of dispersive soft ferrite models for time-domain simulation

International Nuclear Information System (INIS)

DeFord, J.F.; Kamin, G.; Craig, G.D.; Walling, L.

1992-01-01

Ferrite has a variety of applications in accelerator components, and the capability to model this magnetic material in the time domain is an important adjunct to currently available accelerator modeling tool. We describe in this report a material model we have developed for the magnetic characteristics of PE11BL, the ferrite found in the ETA-II (Experimental Test Accelerator-II) induction module. This model, which includes the important magnetic dispersion effects found in most soft ferrites, has been implemented in 1-D and 2-D finite-difference time-domain (FDTD) electromagnetic simulators, and comparisons with analytic and experimental results are presented

Time Domain Terahertz Axial Computed Tomography Non Destructive Evaluation, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — We propose to demonstrate key elements of feasibility for a high speed automated time domain terahertz computed axial tomography (TD-THz CT) non destructive...

THEORETICAL RESEARCH ON HYDRODYNAMICS OF A GEOMETRIC SPAR IN FREQUENCY- AND TIME-DOMAINS

Institute of Scientific and Technical Information of China (English)

WANG Ying; YANG Jian-min; HU Zhi-qiang; XIAO Long-fei

2008-01-01

Considering the coupling effects of the vessel and its riser and mooring system, hydrodynamic analyses of a geometric spar were performed both in frequency- and time-domains. Based on the boundary element method, the 3-D panel model of the geometric spar and the related free water surface model were established, and the first-order and second-order difference-frequency wave loads and other hydrodynamic coefficients were calculated. Frequency domain analysis of the motion Response Amplitude Operators (RAO) and Quadratic Transfer Functions (QTF) and time domain analysis of the response series and spectra in an extreme wave condition were conducted for the coupled system with the mooring lines and risers involved. These analyses were further validated by the physical model test results.

Ultra-broadband THz time-domain spectroscopy of common polymers using THz air photonics

DEFF Research Database (Denmark)

D’Angelo, Francesco; Mics, Zoltán; Bonn, Mischa

2014-01-01

-domain spectrometer employing air-photonics for the generation and detection of single-cycle sub-50 fs THz transients. The time domain measurements provide direct access to both the absorption and refractive index spectra. The polymers LDPE and TOPAS® demonstrate negligible absorption and spectrally-flat refractive...... index across the entire spectroscopy window, revealing the high potential of these polymers for applications in THz photonics such as ultra-broadband polymer-based dielectric mirrors, waveguides, and fibers. Resonant high-frequency polar vibrational modes are observed and assigned in polymers PA6...... and PTFE, and their dielectric functions in the complete frequency window 2-15 THz are theoretically reproduced. Our results demonstrate the potential of ultrabroadband air-photonics-based THz time domain spectroscopy as a valuable analytic tool for materials science....

Stabilization of time domain acoustic boundary element method for the interior problem with impedance boundary conditions.

Science.gov (United States)

Jang, Hae-Won; Ih, Jeong-Guon

2012-04-01

The time domain boundary element method (BEM) is associated with numerical instability that typically stems from the time marching scheme. In this work, a formulation of time domain BEM is derived to deal with all types of boundary conditions adopting a multi-input, multi-output, infinite impulse response structure. The fitted frequency domain impedance data are converted into a time domain expression as a form of an infinite impulse response filter, which can also invoke a modeling error. In the calculation, the response at each time step is projected onto the wave vector space of natural radiation modes, which can be obtained from the eigensolutions of the single iterative matrix. To stabilize the computation, unstable oscillatory modes are nullified, and the same decay rate is used for two nonoscillatory modes. As a test example, a transient sound field within a partially lined, parallelepiped box is used, within which a point source is excited by an octave band impulse. In comparison with the results of the inverse Fourier transform of a frequency domain BEM, the average of relative difference norm in the stabilized time response is found to be 4.4%.

Structural Time Domain Identification (STDI) Toolbox for Use with MATLAB

DEFF Research Database (Denmark)

Kirkegaard, Poul Henning; Andersen, P.; Brincker, Rune

1997-01-01

The Structural Time Domain Identification (STDI) toolbox for use with MATLABTM is developed at Aalborg University, Denmark, based on the system identification research performed during recent years. By now, a reliable set of functions offers a wide spectrum of services for all the important steps...

Structural Time Domain Identification (STDI) Toolbox for Use with MATLAB

DEFF Research Database (Denmark)

Kirkegaard, Poul Henning; Andersen, P.; Brincker, Rune

The Structural Time Domain Identification (STDI) toolbox for use with MATLABTM is developed at Aalborg University, Denmark, based on the system identification research performed during recent years. By now, a reliable set of functions offers a wide spectrum of services for all the important steps...

Nonlinear system identification NARMAX methods in the time, frequency, and spatio-temporal domains

CERN Document Server

Billings, Stephen A

2013-01-01

Nonlinear System Identification: NARMAX Methods in the Time, Frequency, and Spatio-Temporal Domains describes a comprehensive framework for the identification and analysis of nonlinear dynamic systems in the time, frequency, and spatio-temporal domains. This book is written with an emphasis on making the algorithms accessible so that they can be applied and used in practice. Includes coverage of: The NARMAX (nonlinear autoregressive moving average with exogenous inputs) modelThe orthogonal least squares algorithm that allows models to be built term by

Time Domain Terahertz Axial Computed Tomography Non Destructive Evaluation, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — In this Phase 2 project, we propose to develop, construct, and deliver to NASA a computed axial tomography time-domain terahertz (CT TD-THz) non destructive...

Optimal time-domain combination of the two calibrated output quadratures of GEO 600

International Nuclear Information System (INIS)

Hewitson, M; Grote, H; Hild, S; Lueck, H; Ajith, P; Smith, J R; Strain, K A; Willke, B; Woan, G

2005-01-01

GEO 600 is an interferometric gravitational wave detector with a 600 m arm-length and which uses a dual-recycled optical configuration to give enhanced sensitivity over certain frequencies in the detection band. Due to the dual-recycling, GEO 600 has two main output signals, both of which potentially contain gravitational wave signals. These two outputs are calibrated to strain using a time-domain method. In order to simplify the analysis of the GEO 600 data set, it is desirable to combine these two calibrated outputs to form a single strain signal that has optimal signal-to-noise ratio across the detection band. This paper describes a time-domain method for doing this combination. The method presented is similar to one developed for optimally combining the outputs of two colocated gravitational wave detectors. In the scheme presented in this paper, some simplifications are made to allow its implementation using time-domain methods

A wavelet-based PWTD algorithm-accelerated time domain surface integral equation solver

KAUST Repository

Liu, Yang; Yucel, Abdulkadir C.; Gilbert, Anna C.; Bagci, Hakan; Michielssen, Eric

2015-01-01

© 2015 IEEE. The multilevel plane-wave time-domain (PWTD) algorithm allows for fast and accurate analysis of transient scattering from, and radiation by, electrically large and complex structures. When used in tandem with marching-on-in-time (MOT

On the initial condition problem of the time domain PMCHWT surface integral equation

KAUST Repository

Uysal, Ismail Enes; Bagci, Hakan; Ergin, A. Arif; Ulku, H. Arda

2017-01-01

Non-physical, linearly increasing and constant current components are induced in marching on-in-time solution of time domain surface integral equations when initial conditions on time derivatives of (unknown) equivalent currents are not enforced

Acoustic, finite-difference, time-domain technique development

International Nuclear Information System (INIS)

Kunz, K.

1994-01-01

A close analog exists between the behavior of sound waves in an ideal gas and the radiated waves of electromagnetics. This analog has been exploited to obtain an acoustic, finite-difference, time-domain (AFDTD) technique capable of treating small signal vibrations in elastic media, such as air, water, and metal, with the important feature of bending motion included in the behavior of the metal. This bending motion is particularly important when the metal is formed into sheets or plates. Bending motion does not have an analog in electromagnetics, but can be readily appended to the acoustic treatment since it appears as a single additional term in the force equation for plate motion, which is otherwise analogous to the electromagnetic wave equation. The AFDTD technique has been implemented in a code architecture that duplicates the electromagnetic, finite-difference, time-domain technique code. The main difference in the implementation is the form of the first-order coupled differential equations obtained from the wave equation. The gradient of pressure and divergence of velocity appear in these equations in the place of curls of the electric and magnetic fields. Other small changes exist as well, but the codes are essentially interchangeable. The pre- and post-processing for model construction and response-data evaluation of the electromagnetic code, in the form of the TSAR code at Lawrence Livermore National Laboratory, can be used for the acoustic version. A variety of applications is possible, pending validation of the bending phenomenon. The applications include acoustic-radiation-pattern predictions for a submerged object; mine detection analysis; structural noise analysis for cars; acoustic barrier analysis; and symphonic hall/auditorium predictions and speaker enclosure modeling

Methodology for Time-Domain Estimation of Storm-Time Electric Fields Using the 3D Earth Impedance

Science.gov (United States)

Kelbert, A.; Balch, C. C.; Pulkkinen, A. A.; Egbert, G. D.; Love, J. J.; Rigler, E. J.; Fujii, I.

2016-12-01

Magnetic storms can induce geoelectric fields in the Earth's electrically conducting interior, interfering with the operations of electric-power grid industry. The ability to estimate these electric fields at Earth's surface in close to real-time and to provide local short-term predictions would improve the ability of the industry to protect their operations. At any given time, the electric field at the Earth's surface is a function of the time-variant magnetic activity (driven by the solar wind), and the local electrical conductivity structure of the Earth's crust and mantle. For this reason, implementation of an operational electric field estimation service requires an interdisciplinary, collaborative effort between space science, real-time space weather operations, and solid Earth geophysics. We highlight in this talk an ongoing collaboration between USGS, NOAA, NASA, Oregon State University, and the Japan Meteorological Agency, to develop algorithms that can be used for scenario analyses and which might be implemented in a real-time, operational setting. We discuss the development of a time domain algorithm that employs discrete time domain representation of the impedance tensor for a realistic 3D Earth, known as the discrete time impulse response (DTIR), convolved with the local magnetic field time series, to estimate the local electric field disturbances. The algorithm is validated against measured storm-time electric field data collected in the United States and Japan. We also discuss our plans for operational real-time electric field estimation using 3D Earth impedances.

Causality and associative holography of time-and-space domain events

International Nuclear Information System (INIS)

Rebane, Aleksander

2014-01-01

We consider reference-free associative recall of time-and-space domain holograms of arbitrary non-stationary optical object amplitudes or events. We show that if the probe fragment correlates with the recorded event either in space or in time coordinates or in both, then the hologram faithfully reproduces those missing parts (sub-events) that occur simultaneously or later in time with respect to the probe fragment. However, if a missing sub-event occurred before the fragment used as associative probe, then the hologram will not play this information back due to the time arrow imposed by causality. (paper)

Non-Causal Time-Domain Filters for Single-Channel Noise Reduction

DEFF Research Database (Denmark)

Jensen, Jesper Rindom; Benesty, Jacob; Christensen, Mads Græsbøll

2012-01-01

suppression and signal distortion by allowing the filters to be non-causal. Non-causal time-domain filters require knowledge of the future, and are therefore not directly implementable. If the observed signal is processed in blocks, however, the non-causal filters are implementable. In this paper, we propose...

OpenPSTD : The open source implementation of the pseudospectral time-domain method

NARCIS (Netherlands)

Krijnen, T.; Hornikx, M.C.J.; Borkowski, B.

2014-01-01

An open source implementation of the pseudospectral time-domain method for the propagation of sound is presented, which is geared towards applications in the built environment. Being a wavebased method, PSTD captures phenomena like diffraction, but maintains efficiency in processing time and memory

Layered and Laterally Constrained 2D Inversion of Time Domain Induced Polarization Data

DEFF Research Database (Denmark)

Fiandaca, Gianluca; Ramm, James; Auken, Esben

description of the transmitter waveform and of the receiver transfer function allowing for a quantitative interpretation of the parameters. The code has been optimized for parallel computation and the inversion time is comparable to codes inverting just for direct current resistivity. The new inversion......In a sedimentary environment, quasi-layered models often represent the actual geology more accurately than smooth minimum-structure models. We have developed a new layered and laterally constrained inversion algorithm for time domain induced polarization data. The algorithm is based on the time...... transform of a complex resistivity forward response and the inversion extracts the spectral information of the time domain measures in terms of the Cole-Cole parameters. The developed forward code and inversion algorithm use the full time decay of the induced polarization response, together with an accurate...

Evaluation of skin moisturizer effects using terahertz time domain imaging

Science.gov (United States)

Martinez-Meza, L. H.; Rojas-Landeros, S. C.; Castro-Camus, E.; Alfaro-Gomez, M.

2018-02-01

We use terahertz time domain imaging for the evaluation of the effects of skin-moisturizers in vivo. We evaluate three principal substances used in commercial moisturizers: glycerin, hyaluronic acid and lanolin. We image the interaction of the forearm with each of the substances taking terahertz spectra at sequential times. With this, we are able to measure the effect of the substances on the hydration level of the skin in time, determining the feasibility of using THz imaging for the evaluation of the products and their effects on the hydration levels of the skin.

Time-Resolved Fluorescence Spectroscopy and Fluorescence Lifetime Imaging Microscopy for Characterization of Dendritic Polymer Nanoparticles and Applications in Nanomedicine

Directory of Open Access Journals (Sweden)

Alexander Boreham

2016-12-01

Full Text Available The emerging field of nanomedicine provides new approaches for the diagnosis and treatment of diseases, for symptom relief and for monitoring of disease progression. One route of realizing this approach is through carefully constructed nanoparticles. Due to the small size inherent to the nanoparticles a proper characterization is not trivial. This review highlights the application of time-resolved fluorescence spectroscopy and fluorescence lifetime imaging microscopy (FLIM for the analysis of nanoparticles, covering aspects ranging from molecular properties to particle detection in tissue samples. The latter technique is particularly important as FLIM allows for distinguishing of target molecules from the autofluorescent background and, due to the environmental sensitivity of the fluorescence lifetime, also offers insights into the local environment of the nanoparticle or its interactions with other biomolecules. Thus, these techniques offer highly suitable tools in the fields of particle development, such as organic chemistry, and in the fields of particle application, such as in experimental dermatology or pharmaceutical research.

Time-Resolved Fluorescence Spectroscopy and Fluorescence Lifetime Imaging Microscopy for Characterization of Dendritic Polymer Nanoparticles and Applications in Nanomedicine.

Science.gov (United States)

Boreham, Alexander; Brodwolf, Robert; Walker, Karolina; Haag, Rainer; Alexiev, Ulrike

2016-12-24

The emerging field of nanomedicine provides new approaches for the diagnosis and treatment of diseases, for symptom relief and for monitoring of disease progression. One route of realizing this approach is through carefully constructed nanoparticles. Due to the small size inherent to the nanoparticles a proper characterization is not trivial. This review highlights the application of time-resolved fluorescence spectroscopy and fluorescence lifetime imaging microscopy (FLIM) for the analysis of nanoparticles, covering aspects ranging from molecular properties to particle detection in tissue samples. The latter technique is particularly important as FLIM allows for distinguishing of target molecules from the autofluorescent background and, due to the environmental sensitivity of the fluorescence lifetime, also offers insights into the local environment of the nanoparticle or its interactions with other biomolecules. Thus, these techniques offer highly suitable tools in the fields of particle development, such as organic chemistry, and in the fields of particle application, such as in experimental dermatology or pharmaceutical research.

High Time-Resolution 640-Gb/s Clock Recovery Using Time-Domain Optical Fourier Transformation and Narrowband Optical Filter

DEFF Research Database (Denmark)

Guan, P.; Mulvad, Hans Christian Hansen; Kasai, K.

2010-01-01

We present a novel scheme for subharmonic clock recovery from an optical time-division-multiplexing signal using time-domain optical Fourier transformation and a narrowband optical filter. High-resolution 640-Gb/s clock recovery is successfully demonstrated with no pattern dependence. The clock...

Measuring the Moisture Content of Green Wood Using Time Domain Reflectometry

Science.gov (United States)

Laurence Schimleck; Kim Love-Myers; Joe Sanders; Heath Raybon; Richard Daniels; Jerry Mahon; Edward Andrews; Erik Schilling

2011-01-01

The responsible usage of water by facilities that rely on wet log storage in the southern United States has become an issue of great importance as restrictions on water usage have grown in recent years. In order to learn about the dynamics of moisture content in wet-stored logs over time, it is necessary to conduct continuous monitoring of log piles. Time domain...

Differential levels of metabolic activity in isolated versus confluent/partially confluent HeLa cells are analyzed by autofluorescent NAD(P)H using multi-photon FLIM microscopy

Science.gov (United States)

Chandler, Andrea; Chandler, Aaron; Wallrabe, Horst; Periasamy, Ammasi

2017-02-01

NAD(P)H is a known biomarker for cellular metabolism; a higher ratio of enzyme-bound NAD(P)H to free/unbound NAD(P)H indicates an increase in metabolic activity. Free NADH has a shorter fluorescence lifetime (τ1), the bound version (τ2) a longer lifetime. FLIM's unique capability to establish inter alia the relative fractions of τ1 (a1%) and τ2 (a2%) in each pixel, determines the level of metabolic activity. The relative abundances of bound NAD(P)H were analyzed for single cells, confluent and partially confluent cells within 3 Fields-of-View (FoVs). A gradient of increasing a 2% levels of bound NAD(P)H from single, partially confluent to confluent cells was observed.

Time domain series system definition and gear set reliability modeling

International Nuclear Information System (INIS)

Xie, Liyang; Wu, Ningxiang; Qian, Wenxue

2016-01-01

Time-dependent multi-configuration is a typical feature for mechanical systems such as gear trains and chain drives. As a series system, a gear train is distinct from a traditional series system, such as a chain, in load transmission path, system-component relationship, system functioning manner, as well as time-dependent system configuration. Firstly, the present paper defines time-domain series system to which the traditional series system reliability model is not adequate. Then, system specific reliability modeling technique is proposed for gear sets, including component (tooth) and subsystem (tooth-pair) load history description, material priori/posterior strength expression, time-dependent and system specific load-strength interference analysis, as well as statistically dependent failure events treatment. Consequently, several system reliability models are developed for gear sets with different tooth numbers in the scenario of tooth root material ultimate tensile strength failure. The application of the models is discussed in the last part, and the differences between the system specific reliability model and the traditional series system reliability model are illustrated by virtue of several numerical examples. - Highlights: • A new type of series system, i.e. time-domain multi-configuration series system is defined, that is of great significance to reliability modeling. • Multi-level statistical analysis based reliability modeling method is presented for gear transmission system. • Several system specific reliability models are established for gear set reliability estimation. • The differences between the traditional series system reliability model and the new model are illustrated.

Finite difference time domain modeling of spiral antennas

Science.gov (United States)

Penney, Christopher W.; Beggs, John H.; Luebbers, Raymond J.

1992-01-01

The objectives outlined in the original proposal for this project were to create a well-documented computer analysis model based on the finite-difference, time-domain (FDTD) method that would be capable of computing antenna impedance, far-zone radiation patterns, and radar cross-section (RCS). The ability to model a variety of penetrable materials in addition to conductors is also desired. The spiral antennas under study by this project meet these requirements since they are constructed of slots cut into conducting surfaces which are backed by dielectric materials.

Real-time decision support and information gathering system for financial domain

Science.gov (United States)

Tseng, Chiu-Che; Gmytrasiewicz, Piotr J.

2006-05-01

The challenge of the investment domain is that a large amount of diverse information can be potentially relevant to an investment decision, and that, frequently, the decisions have to be made in a timely manner. This presents the potential for better decision support, but poses the challenge of building a decision support agent that gathers information from different sources and incorporates it for timely decision support. These problems motivate us to investigate ways in which the investors can be equipped with a flexible real-time decision support system to be practical in time-critical situations. The flexible real-time decision support system considers a tradeoff between decision quality and computation cost. For this purpose, we propose a system that uses the object oriented Bayesian knowledge base (OOBKB) design to create a decision model at the most suitable level of detail to guide the information gathering activities, and to produce an investment recommendation within a reasonable length of time. The decision models our system uses are implemented as influence diagrams. We validate our system with experiments in a simplified investment domain. The experiments show that our system produces a quality recommendation under different urgency situations. The contribution of our system is that it provides the flexible decision recommendation for an investor under time constraints in a complex environment.

Studies in astronomical time series analysis: Modeling random processes in the time domain

Science.gov (United States)

Scargle, J. D.

1979-01-01

Random process models phased in the time domain are used to analyze astrophysical time series data produced by random processes. A moving average (MA) model represents the data as a sequence of pulses occurring randomly in time, with random amplitudes. An autoregressive (AR) model represents the correlations in the process in terms of a linear function of past values. The best AR model is determined from sampled data and transformed to an MA for interpretation. The randomness of the pulse amplitudes is maximized by a FORTRAN algorithm which is relatively stable numerically. Results of test cases are given to study the effects of adding noise and of different distributions for the pulse amplitudes. A preliminary analysis of the optical light curve of the quasar 3C 273 is given.

All-optical signal processing of OTDM and OFDM signals based on time-domain Optical Fourier Transformation

DEFF Research Database (Denmark)

Clausen, Anders; Guan, Pengyu; Mulvad, Hans Christian Hansen

2014-01-01

All-optical time-domain Optical Fourier Transformation utilised for signal processing of ultra-high-speed OTDM signals and OFDM signals will be presented.......All-optical time-domain Optical Fourier Transformation utilised for signal processing of ultra-high-speed OTDM signals and OFDM signals will be presented....

Full waveform inversion using oriented time-domain imaging method for vertical transverse isotropic media

KAUST Repository

Zhang, Zhendong

2017-07-11

Full waveform inversion for reection events is limited by its linearized update re-quirements given by a process equivalent to migration. Unless the background velocity model is reasonably accurate, the resulting gradient can have an inaccurate update direction leading the inversion to converge what we refer to as local minima of the objective function. In our approach, we consider mild lateral variation in the model, and thus, use a gradient given by the oriented time-domain imaging method. Specifically, we apply the oriented time-domain imaging on the data residual to obtain the geometrical features of the velocity perturbation. After updating the model in the time domain, we convert the perturbation from the time domain to depth using the average velocity. Considering density is constant, we can expand the conventional 1D impedance inversion method to 2D or 3D velocity inversion within the process of full waveform inversion. This method is not only capable of inverting for velocity, but it is also capable of retrieving anisotropic parameters relying on linearized representations of the reection response. To eliminate the cross-talk artifacts between different parameters, we utilize what we consider being an optimal parametrization for this step. To do so, we extend the prestack time-domain migration image in incident angle dimension to incorporate angular dependence needed by the multiparameter inversion. For simple models, this approach provides an efficient and stable way to do full waveform inversion or modified seismic inversion and makes the anisotropic inversion more practicable. The proposed method still needs kinematically accurate initial models since it only recovers the high-wavenumber part as conventional full waveform inversion method does. Results on synthetic data of isotropic and anisotropic cases illustrate the benefits and limitations of this method.

Nonextreme and ultraextreme domain walls and their global space-times

International Nuclear Information System (INIS)

Cvetic, M.; Griffies, S.; Soleng, H.H.

1993-01-01

Nonextreme walls (bubbles with two insides) and ultraextreme walls (bubbles of false vacuum decay) are discussed. Their respective energy densities are higher and lower than that of the corresponding extreme (supersymmetric), planar domain wall. These singularity free space-times exhibit nontrivial causal structure analogous to certain nonextreme black holes. We focus on anti--de Sitter--Minkowski walls and comment on Minkowski-Minkowski walls with trivial extreme limit, as well as walls adjacent to de Sitter space-times with no extreme limit

Fast analysis of wide-band scattering from electrically large targets with time-domain parabolic equation method

Science.gov (United States)

He, Zi; Chen, Ru-Shan

2016-03-01

An efficient three-dimensional time domain parabolic equation (TDPE) method is proposed to fast analyze the narrow-angle wideband EM scattering properties of electrically large targets. The finite difference (FD) of Crank-Nicolson (CN) scheme is used as the traditional tool to solve the time-domain parabolic equation. However, a huge computational resource is required when the meshes become dense. Therefore, the alternating direction implicit (ADI) scheme is introduced to discretize the time-domain parabolic equation. In this way, the reduced transient scattered fields can be calculated line by line in each transverse plane for any time step with unconditional stability. As a result, less computational resources are required for the proposed ADI-based TDPE method when compared with both the traditional CN-based TDPE method and the finite-different time-domain (FDTD) method. By employing the rotating TDPE method, the complete bistatic RCS can be obtained with encouraging accuracy for any observed angle. Numerical examples are given to demonstrate the accuracy and efficiency of the proposed method.

Dancing with the Electrons: Time-Domain and CW In Vivo EPR Imaging

Directory of Open Access Journals (Sweden)

Murali C. Krishna

2008-01-01

Full Text Available The progress in the development of imaging the distribution of unpaired electrons in living systems and the functional and the potential diagnostic dimensions of such an imaging process, using Electron Paramagnetic Resonance Imaging (EPRI, is traced from its origins with emphasis on our own work. The importance of EPR imaging stems from the fact that many paramagnetic probes show oxygen dependent spectral broadening. Assessment of in vivo oxygen concentration is an important factor in radiation oncology in treatment-planning and monitoring treatment-outcome. The emergence of narrow-line trairylmethyl based, bio-compatible spin probes has enabled the development of radiofrequency time-domain EPRI. Spectral information in time-domain EPRI can be achieved by generating a time sequence of T2* or T2 weighted images. Progress in CW imaging has led to the use of rotating gradients, more recently rapid scan with direct detection, and a combination of all the three. Very low field MRI employing Dynamic Nuclear polarization (Overhauser effect is also employed for monitoring tumor hypoxia, and re-oxygenation in vivo. We have also been working on the co-registration of MRI and time domain EPRI on mouse tumor models at 300 MHz using a specially designed resonator assembly. The mapping of the unpaired electron distribution and unraveling the spectral characteristics by using magnetic resonance in presence of stationary and rotating gradients in indeed ‘dancing with the (unpaired electrons’, metaphorically speaking.

On the internal resonant modes in marching-on-in-time solution of the time domain electric field integral equation

KAUST Repository

Shi, Yifei; Bagci, Hakan; Lu, Mingyu

2013-01-01

Internal resonant modes are always observed in the marching-on-in-time (MOT) solution of the time domain electric field integral equation (EFIE), although 'relaxed initial conditions,' which are enforced at the beginning of time marching, should in theory prevent these spurious modes from appearing. It has been conjectured that, numerical errors built up during time marching establish the necessary initial conditions and induce the internal resonant modes. However, this conjecture has never been proved by systematic numerical experiments. Our numerical results in this communication demonstrate that, the internal resonant modes' amplitudes are indeed dictated by the numerical errors. Additionally, it is shown that in a few cases, the internal resonant modes can be made 'invisible' by significantly suppressing the numerical errors. These tests prove the conjecture that the internal resonant modes are induced by numerical errors when the time domain EFIE is solved by the MOT method. © 2013 IEEE.

On the internal resonant modes in marching-on-in-time solution of the time domain electric field integral equation

KAUST Repository

Shi, Yifei

2013-08-01

Internal resonant modes are always observed in the marching-on-in-time (MOT) solution of the time domain electric field integral equation (EFIE), although \\'relaxed initial conditions,\\' which are enforced at the beginning of time marching, should in theory prevent these spurious modes from appearing. It has been conjectured that, numerical errors built up during time marching establish the necessary initial conditions and induce the internal resonant modes. However, this conjecture has never been proved by systematic numerical experiments. Our numerical results in this communication demonstrate that, the internal resonant modes\\' amplitudes are indeed dictated by the numerical errors. Additionally, it is shown that in a few cases, the internal resonant modes can be made \\'invisible\\' by significantly suppressing the numerical errors. These tests prove the conjecture that the internal resonant modes are induced by numerical errors when the time domain EFIE is solved by the MOT method. © 2013 IEEE.

Stationary echo canceling in velocity estimation by time-domain cross-correlation

DEFF Research Database (Denmark)

Jensen, Jørgen Arendt

1993-01-01

The application of stationary echo canceling to ultrasonic estimation of blood velocities using time-domain cross-correlation is investigated. Expressions are derived that show the influence from the echo canceler on the signals that enter the cross-correlation estimator. It is demonstrated...

Shape optimization for non-Newtonian fluids in time-dependent domains

Czech Academy of Sciences Publication Activity Database

Sokolowski, J.; Stebel, Jan

2014-01-01

Roč. 3, č. 2 (2014), s. 331-348 ISSN 2163-2480 R&D Projects: GA ČR GA201/09/0917 Institutional support: RVO:67985840 Keywords : shape optimization * time - dependent domain * incompressible viscous fluid Subject RIV: BA - General Mathematics Impact factor: 0.373, year: 2014 http://www.aimsciences.org/journals/home.jsp?journalID=25

Shape optimization for non-Newtonian fluids in time-dependent domains

Czech Academy of Sciences Publication Activity Database

Sokolowski, J.; Stebel, Jan

2014-01-01

Roč. 3, č. 2 (2014), s. 331-348 ISSN 2163-2480 R&D Projects: GA ČR GA201/09/0917 Institutional support: RVO:67985840 Keywords : shape optimization * time-dependent domain * incompressible viscous fluid Subject RIV: BA - General Mathematics Impact factor: 0.373, year: 2014 http://www.aimsciences.org/journals/home.jsp?journalID=25

Two dimensional microcirculation mapping with real time spatial frequency domain imaging

Science.gov (United States)

Zheng, Yang; Chen, Xinlin; Lin, Weihao; Cao, Zili; Zhu, Xiuwei; Zeng, Bixin; Xu, M.

2018-02-01

We present a spatial frequency domain imaging (SFDI) study of local hemodynamics in the human finger cuticle of healthy volunteers performing paced breathing and the forearm of healthy young adults performing normal breathing with our recently developed Real Time Single Snapshot Multiple Frequency Demodulation - Spatial Frequency Domain Imaging (SSMD-SFDI) system. A two-layer model was used to map the concentrations of deoxy-, oxy-hemoglobin, melanin, epidermal thickness and scattering properties at the subsurface of the forearm and the finger cuticle. The oscillations of the concentrations of deoxy- and oxy-hemoglobin at the subsurface of the finger cuticle and forearm induced by paced breathing and normal breathing, respectively, were found to be close to out-of-phase, attributed to the dominance of the blood flow modulation by paced breathing or heartbeat. Our results suggest that the real time SFDI platform may serve as one effective imaging modality for microcirculation monitoring.

Multiobjective Optimization for Electronic Circuit Design in Time and Frequency Domains

Directory of Open Access Journals (Sweden)

J. Dobes

2013-04-01

Full Text Available The multiobjective optimization provides an extraordinary opportunity for the finest design of electronic circuits because it allows to mathematically balance contradictory requirements together with possible constraints. In this paper, an original and substantial improvement of an existing method for the multiobjective optimization known as GAM (Goal Attainment Method is suggested. In our proposal, the GAM algorithm itself is combined with a procedure that automatically provides a set of parameters -- weights, coordinates of the reference point -- for which the method generates noninferior solutions uniformly spread over an appropriately selected part of the Pareto front. Moreover, the resulting set of obtained solutions is then presented in a suitable graphic form so that the solution representing the most satisfactory tradeoff can be easily chosen by the designer. Our system generates various types of plots that conveniently characterize results of up to four-dimensional problems. Technically, the procedures of the multiobjective optimization were created as a software add-on to the CIA (Circuit Interactive Analyzer program. This way enabled us to utilize many powerful features of this program, including the sensitivity analyses in time and frequency domains. As a result, the system is also able to perform the multiobjective optimization in the time domain and even highly nonlinear circuits can be significantly improved by our program. As a demonstration of this feature, a multiobjective optimization of a C-class power amplifier in the time domain is thoroughly described in the paper. Further, a four-dimensional optimization of a video amplifier is demonstrated with an original graphic representation of the Pareto front, and also some comparison with the weighting method is done. As an example of improving noise properties, a multiobjective optimization of a low-noise amplifier is performed, and the results in the frequency domain are shown

CORRTEX: a compact and versatile system for time domain reflectometry

International Nuclear Information System (INIS)

Deupree, R.G.; Eilers, D.D.; McKown, T.O.; Storey, W.H.

1981-01-01

The CORRTEX (COntinuous Reflectometry for Radius versus Time EXperiments) system was designed to be an adaptable and versatile unit for performing time domain reflectometry (TDR). The system consists of a coaxial cable, a digital TDR, which uses a Motorola 6800 microprocessor, a power source or battery pack, and an output terminal or recording driver. Desirable criteria for the system are discussed as well as the operation of the CORRTEX system. The types of present applications of the CORRTEX system are summarized and data presented

Time Domain Characterization of 1-2 GHz Circular-ended Bowtie Antenna Using Normalizad Impulse Response

Directory of Open Access Journals (Sweden)

Joko Suryana

2010-10-01

Full Text Available Frequency domain analysis is a powerful and compact tool for characterizing the antenna parameters such as gain, radiation pattern and the impedance as a function of frequency. However, if time or space is a major concern, such as in the GPR appication, the time domain analysis would be a very important tool due to their unique capability for determining the echo delay and range profile of target image. In this paper, we will describe the classical theory of system characterization in time domain, and then also propose the mathematical model for characterizing the 1 - 2 GHz circular-ended Bowtie antenna. From the measurement results, we concluded that the implemented Bowtie antenna has good normalized impulse response with very small ringing, so it is suitable for GPR applications.

Postural analysis in time and frequency domains in patients with Ehlers-Danlos syndrome.

Science.gov (United States)

Galli, Manuela; Rigoldi, Chiara; Celletti, Claudia; Mainardi, Luca; Tenore, Nunzio; Albertini, Giorgio; Camerota, Filippo

2011-01-01

The goal of this work is to analyze postural control in Ehlers-Danlos syndrome (EDS) participants in time and frequency domain. This study considered a pathological group composed by 22 EDS participants performing a postural test consisting in maintaining standing position over a force platform for 30s in two conditions: open eyes (OE) and closed eyes (CE). In order to compare pathological group we acquired in the same conditions a control group composed by 20 healthy participants. The obtained center of pressure (COP) signal was analyzed in time and frequency domain using an AR model. Results revealed differences between pathological and control group: EDS participants pointed out difficulties in controlling COP displacements trying to keep it inside the BOS in AP direction and for this reason increased the use of ML mechanism in order to avoid the risk of fall. Also in CE conditions they demonstrated more difficulties in maintaining posture revealing the proprioceptive system is impaired, due to ligament laxity that characterized EDS participants. Frequency domain analysis showed no differences between the two groups, affirming that the changes in time domain reflected really the impairment to the postural control mechanism and not a different strategy assumed by EDS participants. These data could help in decision-making process to establish a correct rehabilitation approach, based on the reinforcing of muscle tone to supply the ligament laxity in order to prevent risks of falls and its consequences. Copyright © 2010 Elsevier Ltd. All rights reserved.

Linearity of Air-Biased Coherent Detection for Terahertz Time-Domain Spectroscopy

DEFF Research Database (Denmark)

Wang, Tianwu; Iwaszczuk, Krzysztof; Wrisberg, Emil Astrup

2016-01-01

The performance of air-biased coherent detection (ABCD) in a broadband two-color laser-induced air plasma system for terahertz time-domain spectroscopy (THz-TDS) has been investigated. Fundamental parameters of the ABCD detection, including signal-to-noise ratio (SNR), dynamic range (DR), and lin...

Optimal time-domain technique for pulse width modulation in power electronics

Directory of Open Access Journals (Sweden)

I. Mayergoyz

2018-05-01

Full Text Available Optimal time-domain technique for pulse width modulation is presented. It is based on exact and explicit analytical solutions for inverter circuits, obtained for any sequence of input voltage rectangular pulses. Two optimal criteria are discussed and illustrated by numerical examples.

Effects of the airwave in time-domain marine controlled-source electromagnetics

NARCIS (Netherlands)

Hunziker, J.W.; Slob, E.C.; Mulder, W.

2011-01-01

In marine time-domain controlled-source electromagnetics (CSEM), there are two different acquisition methods: with horizontal sources for fast and simple data acquisition or with vertical sources for minimizing the effects of the airwave. Illustrations of the electric field as a function of space

Quantitative terahertz time-domain spectroscopy and analysis in chemistry and biology

DEFF Research Database (Denmark)

Jepsen, Peter Uhd

2005-01-01

I will describe how Terahertz Time-Domain Spectroscopy (THz-TDS) can be used for quantitative, broadband spectroscopy in the far-infrared spectral region. Thz-TDS is sensitive to long-range, non-covalent interactions in the condensed phase, for instance intermolecular hydrogen bonding in molecula...

Contactless graphene conductance measurements: the effect of device fabrication on terahertz time-domain spectroscopy

DEFF Research Database (Denmark)

Mackenzie, David; Buron, Jonas Christian Due; Bøggild, Peter

2016-01-01

We perform contactless full-wafer maps of the electrical conductance of a 4-inch wafer of single-layer CVD graphene using terahertz time-domain spectroscopy both before and after deposition of metal contacts and fabrication of devices via laser ablation. We find that there is no significant change...... in the measured conductance of graphene before and after device fabrication. We also show that precise terahertz time-domain spectroscopy can be performed when the beam spot is at sufficient distance (>1.2 mm) from metal contacts....

A convenient accuracy criterion for time domain FE-calculations

DEFF Research Database (Denmark)

Jensen, Morten Skaarup

1997-01-01

An accuracy criterion that is well suited to tome domain finite element (FE) calculations is presented. It is then used to develop a method for selecting time steps and element meshes that produce accurate results without significantly overburderning the computer. Use of this method is illustrated...... with a simple example, where comparison with an analytical solution shows that results are sufficiently accurate, which is not always the case with more primitive mthods for determining the discretisation....

Concept of an ionizing time-domain matter-wave interferometer

OpenAIRE

Nimmrichter, Stefan; Haslinger, Philipp; Hornberger, Klaus; Arndt, Markus

2011-01-01

We discuss the concept of an all-optical and ionizing matter-wave interferometer in the time domain. The proposed setup aims at testing the wave nature of highly massive clusters and molecules, and it will enable new precision experiments with a broad class of atoms, using the same laser system. The propagating particles are illuminated by three pulses of a standing ultraviolet laser beam, which detaches an electron via efficient single photon-absorption. Optical gratings may have periods as ...

Time-domain incomplete Gauss-Newton full-waveform inversion of Gulf of Mexico data

KAUST Repository

AlTheyab, Abdullah; Wang, Xin; Schuster, Gerard T.

2013-01-01

We apply the incomplete Gauss-Newton full-waveform inversion (TDIGN-FWI) to Gulf of Mexico (GOM) data in the space-time domain. In our application, iterative least-squares reverse-time migration (LSRTM) is used to estimate the model update at each

A dark green fluorescent protein as an acceptor for measurement of Förster resonance energy transfer.

Science.gov (United States)

Murakoshi, Hideji; Shibata, Akihiro C E; Nakahata, Yoshihisa; Nabekura, Junichi

2015-10-15

Measurement of Förster resonance energy transfer by fluorescence lifetime imaging microscopy (FLIM-FRET) is a powerful method for visualization of intracellular signaling activities such as protein-protein interactions and conformational changes of proteins. Here, we developed a dark green fluorescent protein (ShadowG) that can serve as an acceptor for FLIM-FRET. ShadowG is spectrally similar to monomeric enhanced green fluorescent protein (mEGFP) and has a 120-fold smaller quantum yield. When FRET from mEGFP to ShadowG was measured using an mEGFP-ShadowG tandem construct with 2-photon FLIM-FRET, we observed a strong FRET signal with low cell-to-cell variability. Furthermore, ShadowG was applied to a single-molecule FRET sensor to monitor a conformational change of CaMKII and of the light oxygen voltage (LOV) domain in HeLa cells. These sensors showed reduced cell-to-cell variability of both the basal fluorescence lifetime and response signal. In contrast to mCherry- or dark-YFP-based sensors, our sensor allowed for precise measurement of individual cell responses. When ShadowG was applied to a separate-type Ras FRET sensor, it showed a greater response signal than did the mCherry-based sensor. Furthermore, Ras activation and translocation of its effector ERK2 into the nucleus could be observed simultaneously. Thus, ShadowG is a promising FLIM-FRET acceptor.

On the mixed discretization of the time domain magnetic field integral equation

KAUST Repository

Ulku, Huseyin Arda; Bogaert, Ignace; Cools, Kristof; Andriulli, Francesco P.; Bagci, Hakan

2012-01-01

Time domain magnetic field integral equation (MFIE) is discretized using divergence-conforming Rao-Wilton-Glisson (RWG) and curl-conforming Buffa-Christiansen (BC) functions as spatial basis and testing functions, respectively. The resulting mixed

Three-dimensional, time-resolved profiling of ferroelectric domain wall dynamics by spectral-domain optical coherence tomography

International Nuclear Information System (INIS)

Haussmann, Alexander; Schmidt, Sebastian; Wehmeier, Lukas; Eng, Lukas M.; Kirsten, Lars; Cimalla, Peter; Koch, Edmund

2017-01-01

We apply here spectral-domain optical coherence tomography (SD-OCT) for the precise detection and temporal tracking of ferroelectric domain walls (DWs) in magnesium-doped periodically poled lithium niobate (Mg:PPLN). We reproducibly map static DWs at an axial (depth) resolution down to ∝ 0.6 μm, being located up to 0.5 mm well inside the single crystalline Mg:PPLN sample. We show that a full 3-dimensional (3D) reconstruction of the DW geometry is possible from the collected data, when applying a special algorithm that accounts for the nonlinear optical dispersion of the material. Our OCT investigation provides valuable reference information on the DWs' polarization charge distribution, which is known to be the key to the electrical conductivity of ferroelectric DWs in such systems. Hence, we carefully analyze the SD-OCT signal dependence both when varying the direction of incident polarization, and when applying electrical fields along the polar axis. Surprisingly, the large backreflection intensities recorded under extraordinary polarization are not affected by any electrical field, at least for field strengths below the switching threshold, while no significant signals above noise floor are detected under ordinary polarization. Finally, we employed the high-speed SD-OCT setup for the real-time DW tracking upon ferroelectric domain switching under high external fields. (copyright 2017 by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Three-dimensional, time-resolved profiling of ferroelectric domain wall dynamics by spectral-domain optical coherence tomography

Energy Technology Data Exchange (ETDEWEB)

Haussmann, Alexander; Schmidt, Sebastian; Wehmeier, Lukas; Eng, Lukas M. [Technische Universitaet Dresden, Institute of Applied Physics and Center for Advancing Electronics Dresden (cfaed), Dresden (Germany); Kirsten, Lars; Cimalla, Peter; Koch, Edmund [Technische Universitaet Dresden, Faculty of Medicine Carl Gustav Carus, Anesthesiology and Intensive Care Medicine, Clinical Sensoring and Monitoring, Dresden (Germany)

2017-08-15

We apply here spectral-domain optical coherence tomography (SD-OCT) for the precise detection and temporal tracking of ferroelectric domain walls (DWs) in magnesium-doped periodically poled lithium niobate (Mg:PPLN). We reproducibly map static DWs at an axial (depth) resolution down to ∝ 0.6 μm, being located up to 0.5 mm well inside the single crystalline Mg:PPLN sample. We show that a full 3-dimensional (3D) reconstruction of the DW geometry is possible from the collected data, when applying a special algorithm that accounts for the nonlinear optical dispersion of the material. Our OCT investigation provides valuable reference information on the DWs' polarization charge distribution, which is known to be the key to the electrical conductivity of ferroelectric DWs in such systems. Hence, we carefully analyze the SD-OCT signal dependence both when varying the direction of incident polarization, and when applying electrical fields along the polar axis. Surprisingly, the large backreflection intensities recorded under extraordinary polarization are not affected by any electrical field, at least for field strengths below the switching threshold, while no significant signals above noise floor are detected under ordinary polarization. Finally, we employed the high-speed SD-OCT setup for the real-time DW tracking upon ferroelectric domain switching under high external fields. (copyright 2017 by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Continuous performance test assessed with time-domain functional near infrared spectroscopy

Science.gov (United States)

Torricelli, Alessandro; Contini, Davide; Spinelli, Lorenzo; Caffini, Matteo; Butti, Michele; Baselli, Giuseppe; Bianchi, Anna M.; Bardoni, Alessandra; Cerutti, Sergio; Cubeddu, Rinaldo

2007-07-01

A time-domain fNIRS multichannel system was used in a sustained attention protocol (continuous performance test) to study activation of the prefrontal cortex. Preliminary results on volounteers show significant activation (decrease in deoxy-hemoglobin and increase in oxy-hemoglobin) in both left and right prefrontal cortex.

Fault Detection of Aircraft Cable via Spread Spectrum Time Domain Reflectometry

Directory of Open Access Journals (Sweden)

Xudong SHI

2014-03-01

Full Text Available As the airplane cable fault detection based on TDR (time domain reflectometry is affected easily by various noise signals, which makes the reflected signal attenuate and distort heavily, failing to locate the fault. In order to solve these problems, a method of spread spectrum time domain reflectometry (SSTDR is introduced in this paper, taking the advantage of the sharp peak of correlation function. The test signal is generated from ML sequence (MLS modulated by sine wave in the same frequency. Theoretically, the test signal has the very high immunity of noise, which can be applied with excellent precision to fault location on the aircraft cable. In this paper, the method of SSTDR was normally simulated in MATLAB. Then, an experimental setup, based on LabVIEW, was organized to detect and locate the fault on the aircraft cable. It has been demonstrated that SSTDR has the high immunity of noise, reducing some detection errors effectively.

Time Domain Filtering of Resolved Images of Sgr A{sup ∗}

Energy Technology Data Exchange (ETDEWEB)

Shiokawa, Hotaka; Doeleman, Sheperd S. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Gammie, Charles F. [Department of Physics, University of Illinois, 1110 West Green Street, Urbana, IL 61801 (United States)

2017-09-01

The goal of the Event Horizon Telescope (EHT) is to provide spatially resolved images of Sgr A*, the source associated with the Galactic Center black hole. Because Sgr A* varies on timescales that are short compared to an EHT observing campaign, it is interesting to ask whether variability contains information about the structure and dynamics of the accretion flow. In this paper, we introduce “time-domain filtering,” a technique to filter time fluctuating images with specific temporal frequency ranges and to demonstrate the power and usage of the technique by applying it to mock millimeter wavelength images of Sgr A*. The mock image data is generated from the General Relativistic Magnetohydrodynamic (GRMHD) simulation and the general relativistic ray-tracing method. We show that the variability on each line of sight is tightly correlated with a typical radius of emission. This is because disk emissivity fluctuates on a timescale of the order of the local orbital period. Time-domain filtered images therefore reflect the model dependent emission radius distribution, which is not accessible in time-averaged images. We show that, in principle, filtered data have the power to distinguish between models with different black-hole spins, different disk viewing angles, and different disk orientations in the sky.

Time-domain SFG spectroscopy using mid-IR pulse shaping: practical and intrinsic advantages.

Science.gov (United States)

Laaser, Jennifer E; Xiong, Wei; Zanni, Martin T

2011-03-24

Sum-frequency generation (SFG) spectroscopy is a ubiquitous tool in the surface sciences. It provides infrared transition frequencies and line shapes that probe the structure and environment of molecules at interfaces. In this article, we apply techniques learned from the multidimensional spectroscopy community to SFG spectroscopy. We implement balanced heterodyne detection to remove scatter and the local oscillator background. Heterodyning also separates the resonant and nonresonant signals by acquiring both the real and imaginary parts of the spectrum. We utilize mid-IR pulse shaping to control the phase and delay of the mid-IR pump pulse. Pulse shaping allows phase cycling for data collection in the rotating frame and additional background subtraction. We also demonstrate time-domain data collection, which is a Fourier transform technique, and has many advantages in signal throughput, frequency resolution, and line shape accuracy over existing frequency domain methods. To demonstrate time-domain SFG spectroscopy, we study an aryl isocyanide on gold, and find that the system has an inhomogeneous structural distribution, in agreement with computational results, but which was not resolved by previous frequency-domain SFG studies. The ability to rapidly and actively manipulate the mid-IR pulse in an SFG pules sequence makes possible new experiments and more accurate spectra. © 2011 American Chemical Society

Analysis of electromagnetic wave interactions on nonlinear scatterers using time domain volume integral equations

KAUST Repository

Ulku, Huseyin Arda

2014-07-06

Effects of material nonlinearities on electromagnetic field interactions become dominant as field amplitudes increase. A typical example is observed in plasmonics, where highly localized fields “activate” Kerr nonlinearities. Naturally, time domain solvers are the method of choice when it comes simulating these nonlinear effects. Oftentimes, finite difference time domain (FDTD) method is used for this purpose. This is simply due to the fact that explicitness of the FDTD renders the implementation easier and the material nonlinearity can be easily accounted for using an auxiliary differential equation (J.H. Green and A. Taflove, Opt. Express, 14(18), 8305-8310, 2006). On the other hand, explicit marching on-in-time (MOT)-based time domain integral equation (TDIE) solvers have never been used for the same purpose even though they offer several advantages over FDTD (E. Michielssen, et al., ECCOMAS CFD, The Netherlands, Sep. 5-8, 2006). This is because explicit MOT solvers have never been stabilized until not so long ago. Recently an explicit but stable MOT scheme has been proposed for solving the time domain surface magnetic field integral equation (H.A. Ulku, et al., IEEE Trans. Antennas Propag., 61(8), 4120-4131, 2013) and later it has been extended for the time domain volume electric field integral equation (TDVEFIE) (S. B. Sayed, et al., Pr. Electromagn. Res. S., 378, Stockholm, 2013). This explicit MOT scheme uses predictor-corrector updates together with successive over relaxation during time marching to stabilize the solution even when time step is as large as in the implicit counterpart. In this work, an explicit MOT-TDVEFIE solver is proposed for analyzing electromagnetic wave interactions on scatterers exhibiting Kerr nonlinearity. Nonlinearity is accounted for using the constitutive relation between the electric field intensity and flux density. Then, this relation and the TDVEFIE are discretized together by expanding the intensity and flux - sing half

Studies in astronomical time series analysis. I - Modeling random processes in the time domain

Science.gov (United States)

Scargle, J. D.

1981-01-01

Several random process models in the time domain are defined and discussed. Attention is given to the moving average model, the autoregressive model, and relationships between and combinations of these models. Consideration is then given to methods for investigating pulse structure, procedures of model construction, computational methods, and numerical experiments. A FORTRAN algorithm of time series analysis has been developed which is relatively stable numerically. Results of test cases are given to study the effect of adding noise and of different distributions for the pulse amplitudes. A preliminary analysis of the light curve of the quasar 3C 272 is considered as an example.

Time-Domain Modeling of RF Antennas and Plasma-Surface Interactions

Directory of Open Access Journals (Sweden)

Jenkins Thomas G.

2017-01-01

Full Text Available Recent advances in finite-difference time-domain (FDTD modeling techniques allow plasma-surface interactions such as sheath formation and sputtering to be modeled concurrently with the physics of antenna near- and far-field behavior and ICRF power flow. Although typical sheath length scales (micrometers are much smaller than the wavelengths of fast (tens of cm and slow (millimeter waves excited by the antenna, sheath behavior near plasma-facing antenna components can be represented by a sub-grid kinetic sheath boundary condition, from which RF-rectified sheath potential variation over the surface is computed as a function of current flow and local plasma parameters near the wall. These local time-varying sheath potentials can then be used, in tandem with particle-in-cell (PIC models of the edge plasma, to study sputtering effects. Particle strike energies at the wall can be computed more accurately, consistent with their passage through the known potential of the sheath, such that correspondingly increased accuracy of sputtering yields and heat/particle fluxes to antenna surfaces is obtained. The new simulation capabilities enable time-domain modeling of plasma-surface interactions and ICRF physics in realistic experimental configurations at unprecedented spatial resolution. We will present results/animations from high-performance (10k-100k core FDTD/PIC simulations of Alcator C-Mod antenna operation.

Comparison of time domain reflectometry, capacitance methods and neutron scattering in soil moisture measurements

International Nuclear Information System (INIS)

Khorasani, A.; Mousavi Shalmani, M. A.; Piervali Bieranvand, N.

2011-01-01

An accurate, precise, fast and ease as well as the ability for measurements in depth are the characteristics that are desirable in measuring soil moisture methods. To compare methods (time domain reflectometry and capacitance) with neutron scattering for soil water monitoring, an experiment was carried out in a randomized complete block design (Split Split plot) on tomato with three replications on the experimental field of International Atomic Energy Agency (Seibersdorf-Austria). The treatment instruments for the soil moisture monitoring (main factor) consist of neutron gauge, Diviner 2000, time domain reflectometer and an EnviroScan and different irrigation systems (first sub factor) consist of trickle and furrow irrigations and different depths of soil (second sub factor) consist of 0-20, 20-40 and 40-60 cm. The results showed that for the neutron gauge and time domain reflectometer the amount of soil moisture in both of trickle and furrow irrigations were the same, but the significant differences were recorded in Diviner 2000 and EnviroScan measurements. The results of this study showed that the neutron gauge is an acceptable and reliable means with the modern technology, with a precision of ±2 mm in 450 mm soil water to a depth of 1.5 meter and can be considered as the most practical method for measuring soil moisture profiles and irrigation planning program. The time domain reflectometer method in most mineral soils, without the need for calibration, with an accuracy ±0.01m 3 m -3 has a good performance in soil moisture and electrical conductivity measurements. The Diviner 2000 and EnviroScan are not well suitable for the above conditions for several reasons such as much higher soil moisture and a large error measurement and also its sensitivity to the soil gap and to the small change in the soil moisture in comparison with the neutron gauge and the time domain reflectometer methods.

The finite-difference time-domain method for electromagnetics with Matlab simulations

CERN Document Server

Elsherbeni, Atef Z

2016-01-01

This book introduces the powerful Finite-Difference Time-Domain method to students and interested researchers and readers. An effective introduction is accomplished using a step-by-step process that builds competence and confidence in developing complete working codes for the design and analysis of various antennas and microwave devices.

Dynamic trafficking of wheat γ-gliadin and of its structural domains in tobacco cells, studied with fluorescent protein fusions

Science.gov (United States)

Francin-Allami, Mathilde; Saumonneau, Amélie; Lavenant, Laurence; Bouder, Axelle; Sparkes, Imogen; Hawes, Chris; Popineau, Yves

2011-01-01

Prolamins, the main storage proteins of wheat seeds, are synthesized and retained in the endoplasmic reticulum (ER) of the endosperm cells, where they accumulate in protein bodies (PBs) and are then exported to the storage vacuole. The mechanisms leading to these events are unresolved. To investigate this unconventional trafficking pathway, wheat γ-gliadin and its isolated repeated N-terminal and cysteine-rich C-terminal domains were fused to fluorescent proteins and expressed in tobacco leaf epidermal cells. The results indicated that γ-gliadin and both isolated domains were able to be retained and accumulated as protein body-like structures (PBLS) in the ER, suggesting that tandem repeats are not the only sequence involved in γ-gliadin ER retention and PBLS formation. The high actin-dependent mobility of γ-gliadin PBLS is also reported, and it is demonstrated that most of them do not co-localize with Golgi body or pre-vacuolar compartment markers. Both γ-gliadin domains are found in the same PBLS when co-expressed, which is most probably due to their ability to interact with each other, as indicated by the yeast two-hybrid and FRET-FLIM experiments. Moreover, when stably expressed in BY-2 cells, green fluorescent protein (GFP) fusions to γ-gliadin and its isolated domains were retained in the ER for several days before being exported to the vacuole in a Golgi-dependent manner, and degraded, leading to the release of the GFP ‘core’. Taken together, the results show that tobacco cells are a convenient model to study the atypical wheat prolamin trafficking with fluorescent protein fusions. PMID:21617248

Terahertz time-domain transmission and reflection spectroscopy of niobium

International Nuclear Information System (INIS)

Hong, Tae Yoon; Choi, Kyu Jin; Park, Byoung Cheol; Ha, Tae Woo; Sim, Kyung Ik; Kim, Jea Hoon; Ha, Dong Gwang; Chang, Yonuk

2013-01-01

We have developed a terahertz time-domain spectroscopy (THz-TDS) system for transmission and reflection measurements of metallic thin films. Using our THz-TDS system, we studied the conventional superconductor niobium (Nb) in the normal state in the spectral range from 5 to 50 cm -1 . Both the real and imaginary parts of the conductivity are acquired without Kramers-Kronig analysis. Nb exhibits a nearly frequency independent real conductivity spectrum in the terahertz range, with a very small imaginary part.

Digital coherent detection research on Brillouin optical time domain reflectometry with simplex pulse codes

International Nuclear Information System (INIS)

Hao Yun-Qi; Ye Qing; Pan Zheng-Qing; Cai Hai-Wen; Qu Rong-Hui

2014-01-01

The digital coherent detection technique has been investigated without any frequency-scanning device in the Brillouin optical time domain reflectometry (BOTDR), where the simplex pulse codes are applied in the sensing system. The time domain signal of every code sequence is collected by the data acquisition card (DAQ). A shift-averaging technique is applied in the frequency domain for the reason that the local oscillator (LO) in the coherent detection is fix-frequency deviated from the primary source. With the 31-bit simplex code, the signal-to-noise ratio (SNR) has 3.5-dB enhancement with the same single pulse traces, accordant with the theoretical analysis. The frequency fluctuation for simplex codes is 14.01 MHz less than that for a single pulse as to 4-m spatial resolution. The results are believed to be beneficial for the BOTDR performance improvement. (general)

Novel Burst Suppression Segmentation in the Joint Time-Frequency Domain for EEG in Treatment of Status Epilepticus

Directory of Open Access Journals (Sweden)

Jaeyun Lee

2016-01-01

Full Text Available We developed a method to distinguish bursts and suppressions for EEG burst suppression from the treatments of status epilepticus, employing the joint time-frequency domain. We obtained the feature used in the proposed method from the joint use of the time and frequency domains, and we estimated the decision as to whether the measured EEG was a burst segment or suppression segment by the maximum likelihood estimation. We evaluated the performance of the proposed method in terms of its accordance with the visual scores and estimation of the burst suppression ratio. The accuracy was higher than the sole use of the time or frequency domains, as well as conventional methods conducted in the time domain. In addition, probabilistic modeling provided a more simplified optimization than conventional methods. Burst suppression quantification necessitated precise burst suppression segmentation with an easy optimization; therefore, the excellent discrimination and the easy optimization of burst suppression by the proposed method appear to be beneficial.

Coherent combining pulse bursts in time domain

Science.gov (United States)

Galvanauskas, Almantas

2018-01-09

A beam combining and pulse stacking technique is provided that enhances laser pulse energy by coherent stacking pulse bursts (i.e. non-periodic pulsed signals) in time domain. This energy enhancement is achieved by using various configurations of Fabry-Perot, Gires-Tournois and other types of resonant cavities, so that a multiple-pulse burst incident at either a single input or multiple inputs of the system produces an output with a solitary pulse, which contains the summed energy of the incident multiple pulses from all beams. This disclosure provides a substantial improvement over conventional coherent-combining methods in that it achieves very high pulse energies using a relatively small number of combined laser systems, thus providing with orders of magnitude reduction in system size, complexity, and cost compared to current combining approaches.

Time-domain hybrid method for simulating large amplitude motions of ships advancing in waves

Directory of Open Access Journals (Sweden)

Shukui Liu

2011-03-01

Full Text Available Typical results obtained by a newly developed, nonlinear time domain hybrid method for simulating large amplitude motions of ships advancing with constant forward speed in waves are presented. The method is hybrid in the way of combining a time-domain transient Green function method and a Rankine source method. The present approach employs a simple double integration algorithm with respect to time to simulate the free-surface boundary condition. During the simulation, the diffraction and radiation forces are computed by pressure integration over the mean wetted surface, whereas the incident wave and hydrostatic restoring forces/moments are calculated on the instantaneously wetted surface of the hull. Typical numerical results of application of the method to the seakeeping performance of a standard containership, namely the ITTC S175, are herein presented. Comparisons have been made between the results from the present method, the frequency domain 3D panel method (NEWDRIFT of NTUA-SDL and available experimental data and good agreement has been observed for all studied cases between the results of the present method and comparable other data.

Agreement of Anterior Segment Parameters Obtained From Swept-Source Fourier-Domain and Time-Domain Anterior Segment Optical Coherence Tomography.

Science.gov (United States)

Chansangpetch, Sunee; Nguyen, Anwell; Mora, Marta; Badr, Mai; He, Mingguang; Porco, Travis C; Lin, Shan C

2018-03-01

To assess the interdevice agreement between swept-source Fourier-domain and time-domain anterior segment optical coherence tomography (AS-OCT). Fifty-three eyes from 41 subjects underwent CASIA2 and Visante OCT imaging. One hundred eighty-degree axis images were measured with the built-in two-dimensional analysis software for the swept-source Fourier-domain AS-OCT (CASIA2) and a customized program for the time-domain AS-OCT (Visante OCT). In both devices, we examined the angle opening distance (AOD), trabecular iris space area (TISA), angle recess area (ARA), anterior chamber depth (ACD), anterior chamber width (ACW), and lens vault (LV). Bland-Altman plots and intraclass correlation (ICC) were performed. Orthogonal linear regression assessed any proportional bias. ICC showed strong correlation for LV (0.925) and ACD (0.992) and moderate agreement for ACW (0.801). ICC suggested good agreement for all angle parameters (0.771-0.878) except temporal AOD500 (0.743) and ARA750 (nasal 0.481; temporal 0.481). There was a proportional bias in nasal ARA750 (slope 2.44, 95% confidence interval [CI]: 1.95-3.18), temporal ARA750 (slope 2.57, 95% CI: 2.04-3.40), and nasal TISA500 (slope 1.30, 95% CI: 1.12-1.54). Bland-Altman plots demonstrated in all measured parameters a minimal mean difference between the two devices (-0.089 to 0.063); however, evidence of constant bias was found in nasal AOD250, nasal AOD500, nasal AOD750, nasal ARA750, temporal AOD500, temporal AOD750, temporal ARA750, and ACD. Among the parameters with constant biases, CASIA2 tends to give the larger numbers. Both devices had generally good agreement. However, there were proportional and constant biases in most angle parameters. Thus, it is not recommended that values be used interchangeably.

Physical optics far field inverse scattering in the time domain

International Nuclear Information System (INIS)

Bleistein, N.

1976-01-01

The physical optics far field inverse scattering (POFFIS) identity relates the phase and range normalized far field back scattering amplitude to the spatial Fourier transform of the characteristic function of the scattering obstacle. The characteristic function is equal to unity in the region occupied by the obstacle and zero elsewhere. The original identity was derived by Bojarski for impulsive point sources. The result is extended to sources of arbitrary time dependence. One obtains an alternative form of Bojarski's POFFIS identity. One also derives a POFFIS identity in the time domain. Numerically synthesized checks on the method are provided

Synchronous machine parameter identification in frequency and time domain

Directory of Open Access Journals (Sweden)

Hasni M.

2007-01-01

Full Text Available This paper presents the results of a frequency and time-domain identification procedure to estimate the linear parameters of a salient-pole synchronous machine at standstill. The objective of this study is to use several input signals to identify the model structure and parameters of a salient-pole synchronous machine from standstill test data. The procedure consists to define, to conduct the standstill tests and also to identify the model structure. The signals used for identification are the different excitation voltages at standstill and the flowing current in different windings. We estimate the parameters of operational impedances, or in other words the reactance and the time constants. The tests were carried out on synchronous machine of 1.5 kVA 380V 1500 rpm.

Near-infrared laser, time domain, breast tumour detection system

International Nuclear Information System (INIS)

Joblin, A.J.

1996-01-01

Full text: The use of near-infrared laser, time domain techniques have been proposed for some time now as an alternative to X-ray mammography, as a means of mass screening for breast disease. The great driving force behind this research has been that near-infrared photons are a non-ionising radiation, which affords a greater degree of patient safety than when using X-rays. This would mean that women at risk of breast disease could be screened with a near-infrared laser imaging system, much more regularly than with an X-ray mammography system, which should allow for the earlier detection and treatment of breast disease. This paper presents a theoretical investigation of the performance of a near-infrared, time domain breast imaging system. The performance of the imaging system is characterised by the resolution and contrast parameters, which were studied using a numerical finite difference calculation method. The finite difference method is used to solve the diffusion equation for the photon transport through the inhomogeneous breast tissue medium. Optimal performance was found to be obtained with short photon times of flight. However the signal to noise ratio decreases rapidly as the photon time of flight is decreased. The system performance will therefore be limited by the noise equivalent power of the time resolved detection system, which is the signal incident on the time resolved detection system which gives a signal to noise ratio of 1:1. Photon times of flight shorter than 500 ps are not practical with current technology, which places limits on the resolution and contrast. The photon signal throughput can be increased by increasing the size of the laser beam width, by increasing the size of the aperture stop of the detector, by increasing the laser pulse duration or decreasing the detector time resolution. Best system performance is found by optimising these parameters for a given time gating and detector system characteristic (NEP). It was found that the

Seismic response of three-dimensional topographies using a time-domain boundary element method

Science.gov (United States)

Janod, François; Coutant, Olivier

2000-08-01

We present a time-domain implementation for a boundary element method (BEM) to compute the diffraction of seismic waves by 3-D topographies overlying a homogeneous half-space. This implementation is chosen to overcome the memory limitations arising when solving the boundary conditions with a frequency-domain approach. This formulation is flexible because it allows one to make an adaptive use of the Green's function time translation properties: the boundary conditions solving scheme can be chosen as a trade-off between memory and cpu requirements. We explore here an explicit method of solution that requires little memory but a high cpu cost in order to run on a workstation computer. We obtain good results with four points per minimum wavelength discretization for various topographies and plane wave excitations. This implementation can be used for two different aims: the time-domain approach allows an easier implementation of the BEM in hybrid methods (e.g. coupling with finite differences), and it also allows one to run simple BEM models with reasonable computer requirements. In order to keep reasonable computation times, we do not introduce any interface and we only consider homogeneous models. Results are shown for different configurations: an explosion near a flat free surface, a plane wave vertically incident on a Gaussian hill and on a hemispherical cavity, and an explosion point below the surface of a Gaussian hill. Comparison is made with other numerical methods, such as finite difference methods (FDMs) and spectral elements.

Time-domain least-squares migration using the Gaussian beam summation method

Science.gov (United States)

Yang, Jidong; Zhu, Hejun; McMechan, George; Yue, Yubo

2018-04-01

With a finite recording aperture, a limited source spectrum and unbalanced illumination, traditional imaging methods are insufficient to generate satisfactory depth profiles with high resolution and high amplitude fidelity. This is because traditional migration uses the adjoint operator of the forward modeling rather than the inverse operator. We propose a least-squares migration approach based on the time-domain Gaussian beam summation, which helps to balance subsurface illumination and improve image resolution. Based on the Born approximation for the isotropic acoustic wave equation, we derive a linear time-domain Gaussian beam modeling operator, which significantly reduces computational costs in comparison with the spectral method. Then, we formulate the corresponding adjoint Gaussian beam migration, as the gradient of an L2-norm waveform misfit function. An L1-norm regularization is introduced to the inversion to enhance the robustness of least-squares migration, and an approximated diagonal Hessian is used as a preconditioner to speed convergence. Synthetic and field data examples demonstrate that the proposed approach improves imaging resolution and amplitude fidelity in comparison with traditional Gaussian beam migration.

A Xanthomonas citri subsp citri hypothetical protein related to virulence contains a non-functional HD domain and is implicated in flagellar motility.

Science.gov (United States)

Vieira, F C F; Gonçalves, A M; Mendoza, E F R; Ferreira, R M; Costa, M L M; Balbuena, T S; Sebinelli, H G; Ciancaglini, P; Pizauro Junior, J M; Ferro, J A

2017-08-31

Citrus canker, caused by the Gram-negative bacterium Xanthomonas citri subsp citri (Xac), severely affects most economically important citrus varieties worldwide. A previous study showed that disruption of the ORF XAC1201 from the Xac 306 strain by transposon Tn5 decreased bacterium virulence in the Rangpur lime host (Citrus limonia L. Osbeck). However, little is known regarding the possible function of the hypothetical protein XAC1201 and how it affects the virulence of Xac 306. Here, we confirmed that disruption of ORF XAC1201 reduces Xac 306 virulence in two different hosts, delaying the onset of typical symptoms. In silico analysis suggested that XAC1201 interacts with the flagellar proteins FliM and FliL, known to be an important factor for virulence. In fact, motility assays revealed that the XAC1201 mutant has a significant difference in motility compared to the wild-type Xac 306. Also, a 3-D structure model revealed modified cofactor binding sites and suggested that XAC1201 has a non-functional HD domain. This hypothesis was confirmed by enzymatic assays performed in purified, XAC1201 recombinant protein expressed in Escherichia coli, which revealed no significant activities previously associated with HD domains for the tested substrates. Thus, the role of the XAC1201 protein in Xac 306 virulence seems to be related to flagellar motility, although a non-classic role for the HD domain cannot be dismissed.

A time-domain method to generate artificial time history from a given reference response spectrum

Energy Technology Data Exchange (ETDEWEB)

Shin, Gang Sik [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of); Song, Oh Seop [Dept. of Mechanical Engineering, Chungnam National University, Daejeon (Korea, Republic of)

2016-06-15

Seismic qualification by test is widely used as a way to show the integrity and functionality of equipment that is related to the overall safety of nuclear power plants. Another means of seismic qualification is by direct integration analysis. Both approaches require a series of time histories as an input. However, in most cases, the possibility of using real earthquake data is limited. Thus, artificial time histories are widely used instead. In many cases, however, response spectra are given. Thus, most of the artificial time histories are generated from the given response spectra. Obtaining the response spectrum from a given time history is straightforward. However, the procedure for generating artificial time histories from a given response spectrum is difficult and complex to understand. Thus, this paper presents a simple time-domain method for generating a time history from a given response spectrum; the method was shown to satisfy conditions derived from nuclear regulatory guidance.

A time-domain method to generate artificial time history from a given reference response spectrum

International Nuclear Information System (INIS)

Shin, Gang Sik; Song, Oh Seop

2016-01-01

Seismic qualification by test is widely used as a way to show the integrity and functionality of equipment that is related to the overall safety of nuclear power plants. Another means of seismic qualification is by direct integration analysis. Both approaches require a series of time histories as an input. However, in most cases, the possibility of using real earthquake data is limited. Thus, artificial time histories are widely used instead. In many cases, however, response spectra are given. Thus, most of the artificial time histories are generated from the given response spectra. Obtaining the response spectrum from a given time history is straightforward. However, the procedure for generating artificial time histories from a given response spectrum is difficult and complex to understand. Thus, this paper presents a simple time-domain method for generating a time history from a given response spectrum; the method was shown to satisfy conditions derived from nuclear regulatory guidance

Explaining the Substantial Inter-Domain and Over-Time Correlations in Student Achievement: The Importance of Stable Student Attributes

Science.gov (United States)

Marks, Gary N.

2016-01-01

Multi-domain and longitudinal studies of student achievement routinely find moderate to strong correlations across achievement domains and even stronger within-domain correlations over time. The purpose of this study is to examine the sources of these patterns analysing student achievement in 5 domains across Years 3, 5 and 7. The analysis is of…

Hybrid Fourier pseudospectral/discontinuous Galerkin time-domain method for arbitrary boundary conditions

NARCIS (Netherlands)

Pagan Munoz, R.; Hornikx, M.C.J.

The wave-based Fourier Pseudospectral time-domain (Fourier-PSTD) method was shown to be an effective way of modeling outdoor acoustic propagation problems as described by the linearized Euler equations (LEE), but is limited to real-valued frequency independent boundary conditions and predominantly

OpenPSTD : The open source pseudospectral time-domain method for acoustic propagation

NARCIS (Netherlands)

Hornikx, M.C.J.; Krijnen, T.F.; van Harten, L.

2016-01-01

An open source implementation of the Fourier pseudospectral time-domain (PSTD) method for computing the propagation of sound is presented, which is geared towards applications in the built environment. Being a wave-based method, PSTD captures phenomena like diffraction, but maintains efficiency in

Discontinuous Galerkin Time-Domain Modeling of Graphene Nano-Ribbon Incorporating the Spatial Dispersion Effects

KAUST Repository

Li, Ping; Jiang, Li Jun; Bagci, Hakan

2018-01-01

It is well known that graphene demonstrates spatial dispersion properties, i.e., its conductivity is nonlocal and a function of spectral wave number (momentum operator) q. In this paper, to account for effects of spatial dispersion on transmission of high speed signals along graphene nano-ribbon (GNR) interconnects, a discontinuous Galerkin time-domain (DGTD) algorithm is proposed. The atomically-thick GNR is modeled using a nonlocal transparent surface impedance boundary condition (SIBC) incorporated into the DGTD scheme. Since the conductivity is a complicated function of q (and one cannot find an analytical Fourier transform pair between q and spatial differential operators), an exact time domain SIBC model cannot be derived. To overcome this problem, the conductivity is approximated by its Taylor series in spectral domain under low-q assumption. This approach permits expressing the time domain SIBC in the form of a second-order partial differential equation (PDE) in current density and electric field intensity. To permit easy incorporation of this PDE with the DGTD algorithm, three auxiliary variables, which degenerate the second-order (temporal and spatial) differential operators to first-order ones, are introduced. Regarding to the temporal dispersion effects, the auxiliary differential equation (ADE) method is utilized to eliminates the expensive temporal convolutions. To demonstrate the applicability of the proposed scheme, numerical results, which involve characterization of spatial dispersion effects on the transfer impedance matrix of GNR interconnects, are presented.

Discontinuous Galerkin Time-Domain Modeling of Graphene Nano-Ribbon Incorporating the Spatial Dispersion Effects

KAUST Repository

Li, Ping

2018-04-13

It is well known that graphene demonstrates spatial dispersion properties, i.e., its conductivity is nonlocal and a function of spectral wave number (momentum operator) q. In this paper, to account for effects of spatial dispersion on transmission of high speed signals along graphene nano-ribbon (GNR) interconnects, a discontinuous Galerkin time-domain (DGTD) algorithm is proposed. The atomically-thick GNR is modeled using a nonlocal transparent surface impedance boundary condition (SIBC) incorporated into the DGTD scheme. Since the conductivity is a complicated function of q (and one cannot find an analytical Fourier transform pair between q and spatial differential operators), an exact time domain SIBC model cannot be derived. To overcome this problem, the conductivity is approximated by its Taylor series in spectral domain under low-q assumption. This approach permits expressing the time domain SIBC in the form of a second-order partial differential equation (PDE) in current density and electric field intensity. To permit easy incorporation of this PDE with the DGTD algorithm, three auxiliary variables, which degenerate the second-order (temporal and spatial) differential operators to first-order ones, are introduced. Regarding to the temporal dispersion effects, the auxiliary differential equation (ADE) method is utilized to eliminates the expensive temporal convolutions. To demonstrate the applicability of the proposed scheme, numerical results, which involve characterization of spatial dispersion effects on the transfer impedance matrix of GNR interconnects, are presented.

Time-domain single-source integral equations for analyzing scattering from homogeneous penetrable objects

KAUST Repository

Valdé s, Felipe; Andriulli, Francesco P.; Bagci, Hakan; Michielssen, Eric

2013-01-01

Single-source time-domain electric-and magnetic-field integral equations for analyzing scattering from homogeneous penetrable objects are presented. Their temporal discretization is effected by using shifted piecewise polynomial temporal basis

Numerical simulation of electromagnetic waves in Schwarzschild space-time by finite difference time domain method and Green function method

Science.gov (United States)

Jia, Shouqing; La, Dongsheng; Ma, Xuelian

2018-04-01

The finite difference time domain (FDTD) algorithm and Green function algorithm are implemented into the numerical simulation of electromagnetic waves in Schwarzschild space-time. FDTD method in curved space-time is developed by filling the flat space-time with an equivalent medium. Green function in curved space-time is obtained by solving transport equations. Simulation results validate both the FDTD code and Green function code. The methods developed in this paper offer a tool to solve electromagnetic scattering problems.

The development of efficient numerical time-domain modeling methods for geophysical wave propagation

Science.gov (United States)

Zhu, Lieyuan

This Ph.D. dissertation focuses on the numerical simulation of geophysical wave propagation in the time domain including elastic waves in solid media, the acoustic waves in fluid media, and the electromagnetic waves in dielectric media. This thesis shows that a linear system model can describe accurately the physical processes of those geophysical waves' propagation and can be used as a sound basis for modeling geophysical wave propagation phenomena. The generalized stability condition for numerical modeling of wave propagation is therefore discussed in the context of linear system theory. The efficiency of a series of different numerical algorithms in the time-domain for modeling geophysical wave propagation are discussed and compared. These algorithms include the finite-difference time-domain method, pseudospectral time domain method, alternating directional implicit (ADI) finite-difference time domain method. The advantages and disadvantages of these numerical methods are discussed and the specific stability condition for each modeling scheme is carefully derived in the context of the linear system theory. Based on the review and discussion of these existing approaches, the split step, ADI pseudospectral time domain (SS-ADI-PSTD) method is developed and tested for several cases. Moreover, the state-of-the-art stretched-coordinate perfect matched layer (SCPML) has also been implemented in SS-ADI-PSTD algorithm as the absorbing boundary condition for truncating the computational domain and absorbing the artificial reflection from the domain boundaries. After algorithmic development, a few case studies serve as the real-world examples to verify the capacities of the numerical algorithms and understand the capabilities and limitations of geophysical methods for detection of subsurface contamination. The first case is a study using ground penetrating radar (GPR) amplitude variation with offset (AVO) for subsurface non-aqueous-liquid (NAPL) contamination. The

Time-domain simulation and waveform reconstruction for shielding effectiveness of materials against electromagnetic pulse

International Nuclear Information System (INIS)

Hu, Xiao-feng; Chen, Xiang; Wei, Ming

2013-01-01

Shielding effectiveness (SE) of materials of current testing standards is often carried out by using continuous-wave measurement and amplitude-frequency characteristics curve is used to characterize the results. However, with in-depth study of high-power electromagnetic pulse (EMP) interference, it was discovered that only by frequency-domain SE of materials cannot be completely characterized by shielding performance of time-domain pulsed-field. And there is no uniform testing methods and standards of SE of materials against EMP. In this paper, the method of minimum phase transfer function is used to reconstruct shielded time-domain waveform based on the analysis of the waveform reconstruction method. Pulse of plane waves through an infinite planar material is simulated by using CST simulation software. The reconstructed waveform and simulation waveform is compared. The results show that the waveform reconstruction method based on the minimum phase can be well estimated EMP waveform through the infinite planar materials.

Gastric Emptying Assessment in Frequency and Time Domain Using Bio-impedance: Preliminary Results

Science.gov (United States)

Huerta-Franco, R.; Vargas-Luna, M.; Hernández, E.; Córdova, T.; Sosa, M.; Gutiérrez, G.; Reyes, P.; Mendiola, C.

2006-09-01

The impedance assessment to measure gastric emptying and in general gastric activity has been reported since 1985. The physiological interpretation of these measurements, is still under research. This technique usually uses a single frequency, and the conductivity parameter. The frequency domain and the Fourier analysis of the time domain behavior of the gastric impedance in different gastric conditions (fasting state, and after food administration) has not been explored in detail. This work presents some insights of the potentiality of these alternative methodologies to measure gastric activity.

Heliborne time-domain electromagnetic (TEM) surveys for uranium exploration

International Nuclear Information System (INIS)

Chaturvedi, A.K.

2015-01-01

Airborne geophysical surveys have been used extensively in petroleum, mineral exploration, and environmental mapping. Of all the geophysical methods, Electromagnetic (EM) methods, both ground and airborne are used to map the conductive ore bodies buried in the resistive bed rock. Mapping resistivity variations can help unravel complex geological problems and identify areas of hidden potential. Besides the traditional applications to ground water investigations and other natural resource exploration and geological mapping, a number of new applications have been reported. These include hazardous-waste characterization studies, precision agriculture applications, archaeological surveys etc. Airborne Electromagnetic (AEM) methods have undergone rapid improvements over the past few decades. Several new airborne Time Do-main EM (TDEM) systems appeared; existing systems were updated and/or enhanced. The use of natural field (passive) EM surveys continued to increase, with new or improved systems becoming available for both airborne and ground surveys. The number of large airborne survey systems with combined EM, magnetic, gravimetric and gamma-ray spectrometric capabilities also increased. Exploration of a mineral deposit is a multi-stage and multi-disciplinary approach that commences from regional investigations and concludes with establishing of a deposit. As economics play a major role in exploration, a proper integrated study is always beneficial in narrowing down the potential mineral target zones. Heliborne geophysical surveys are being conducted world-wide for exploration of base metals, gold, phosphorite, oil, uranium etc. that are very effective tool in identifying zones of interest accurately, economically and with less span of time. These surveys give a very good insight of surface and sub-surface geophysical signatures that can be attributed to geology with proper modeling. Heliborne Time - domain Electromagnetic (TEM) methods are well known for search of

Nonlinear time-domain soil–structure interaction analysis of embedded reactor structures subjected to earthquake loads

Energy Technology Data Exchange (ETDEWEB)

Solberg, Jerome M., E-mail: solberg2@llnl.gov [Methods Development Group, Lawrence Livermore Nat’l Lab, P.O. Box 808, Mailstop L-125, Livermore, CA 94550 (United States); Hossain, Quazi, E-mail: hossain1@llnl.gov [Structural and Applied Mechanics Group, Lawrence Livermore Nat’l Lab, P.O. Box 808, Mailstop L-129, Livermore, CA 94550 (United States); Mseis, George, E-mail: george.mseis@gmail.com [Structural and Applied Mechanics Group, Lawrence Livermore Nat’l Lab, P.O. Box 808, Mailstop L-129, Livermore, CA 94550 (United States)

2016-08-01

Highlights: • Derived modified version of Bielak’s SSI method for nonlinear time-domain analysis. • Utilized a Ramberg–Osgood material with parameters that can be fit to EPRI data. • Matched vertically propagating shear wave results from CARES. • Applied this technique to a representative SMR, compared well with SASSI. • The technique is extensible to other material models and nonlinear effects. - Abstract: A generalized time-domain method for soil–structure interaction analysis is developed, based upon an extension of the work of the domain reduction method of Bielak et al. The methodology is combined with the use of a simple hysteretic soil model based upon the Ramberg–Osgood formulation and applied to a notional Small Modular Reactor. These benchmark results compare well (with some caveats) with those obtained by using the industry-standard frequency-domain code SASSI. The methodology provides a path forward for investigation of other sources of nonlinearity, including those associated with the use of more physically-realistic material models incorporating pore-pressure effects, gap opening/closing, the effect of nonlinear structural elements, and 3D seismic inputs.

Driven by the future : Future time perspective across life domains and cultures

NARCIS (Netherlands)

Andre, L.

2018-01-01

Contemplating about the future is inevitable for our life and goal strivings. Consequently, Future Time Perspective (FTP) – individuals’ attitudes towards the future as a motivator for attitudes and behaviors – has been researched across disciplines and life domains. However, little is known about

Research of time-domain equivalent circuit method in solving dispersion of coupled-cavity traveling-wave tube

International Nuclear Information System (INIS)

Li Wenjun; China Academy of Engineering Physics, Mianyang; Xu Zhou; Li Ming; Yang Xingfan; Chen Yanan; Liu Jie; Jin Xiao; Lin Yuzheng

2008-01-01

In this paper, a time-domain equivalent circuit method is applied to solve dispersion of coupled-cavity travelling-wave tube (CCTWT). First, the time-domain circuit equations of CCTWT coupled-cavity chain are deduced from the equivalent circuit model. Then, the equations are solved numerically by fourth-order Runge-Kutta method and a program CTTDCP is developed using MATLAB. Last, a L-band CCTWT is calculated using CTTDCP and the cavity pass-band of this tube is computed to be 1.08-1.48 GHz, which is consistent with the experimental results and the simulation results of electromagnetic code and demonstrates the validity of the time-domain equivalent circuit method. In addition, a new design method which uses the equivalent circuit method and electromagnetic simulation together to optimize the cold cavity characteristics of CCTWT is proposed. (authors)

Hybrid Fourier pseudospectral/discontinuous Galerkin time-domain method for wave propagation

Science.gov (United States)

Pagán Muñoz, Raúl; Hornikx, Maarten

2017-11-01

The Fourier Pseudospectral time-domain (Fourier PSTD) method was shown to be an efficient way of modelling acoustic propagation problems as described by the linearized Euler equations (LEE), but is limited to real-valued frequency independent boundary conditions and predominantly staircase-like boundary shapes. This paper presents a hybrid approach to solve the LEE, coupling Fourier PSTD with a nodal Discontinuous Galerkin (DG) method. DG exhibits almost no restrictions with respect to geometrical complexity or boundary conditions. The aim of this novel method is to allow the computation of complex geometries and to be a step towards the implementation of frequency dependent boundary conditions by using the benefits of DG at the boundaries, while keeping the efficient Fourier PSTD in the bulk of the domain. The hybridization approach is based on conformal meshes to avoid spatial interpolation of the DG solutions when transferring values from DG to Fourier PSTD, while the data transfer from Fourier PSTD to DG is done utilizing spectral interpolation of the Fourier PSTD solutions. The accuracy of the hybrid approach is presented for one- and two-dimensional acoustic problems and the main sources of error are investigated. It is concluded that the hybrid methodology does not introduce significant errors compared to the Fourier PSTD stand-alone solver. An example of a cylinder scattering problem is presented and accurate results have been obtained when using the proposed approach. Finally, no instabilities were found during long-time calculation using the current hybrid methodology on a two-dimensional domain.

Domain-Specific and Unspecific Reaction Times in Experienced Team Handball Goalkeepers and Novices.

Science.gov (United States)

Helm, Fabian; Reiser, Mathias; Munzert, Jörn

2016-01-01

In our everyday environments, we are constantly having to adapt our behavior to changing conditions. Hence, processing information is a fundamental cognitive activity, especially the linking together of perceptual and action processes. In this context, expertise research in the sport domain has concentrated on arguing that superior processing performance is driven by an advantage to be found in anticipatory processes (see Williams et al., 2011, for a review). This has resulted in less attention being paid to the benefits coming from basic internal perceptual-motor processing. In general, research on reaction time (RT) indicates that practicing a RT task leads to an increase in processing speed (Mowbray and Rhoades, 1959; Rabbitt and Banerji, 1989). Against this background, the present study examined whether the speed of internal processing is dependent on or independent from domain-specific motor expertise in unpredictable stimulus-response tasks and in a double stimulus-response paradigm. Thirty male participants (15 team handball goalkeepers and 15 novices) performed domain-unspecific simple or choice stimulus-response (CSR) tasks as well as CSR tasks that were domain-specific only for goalkeepers. As expected, results showed significantly faster RTs for goalkeepers on domain-specific tasks, whereas novices' RTs were more frequently excessively long. However, differences between groups in the double stimulus-response paradigm were not significant. It is concluded that the reported expertise advantage might be due to recalling stored perceptual-motor representations for the domain-specific tasks, implying that experience with (practice of) a motor task explicitly enhances the internal processing of other related domain-specific tasks.

Finite difference time domain solution of electromagnetic scattering on the hypercube

International Nuclear Information System (INIS)

Calalo, R.H.; Lyons, J.R.; Imbriale, W.A.

1988-01-01

Electromagnetic fields interacting with a dielectric or conducting structure produce scattered electromagnetic fields. To model the fields produced by complicated, volumetric structures, the finite difference time domain (FDTD) method employs an iterative solution to Maxwell's time dependent curl equations. Implementations of the FDTD method intensively use memory and perform numerous calculations per time step iteration. The authors have implemented an FDTD code on the California Institute of Technology/Jet Propulsion Laboratory Mark III Hypercube. This code allows to solve problems requiring as many as 2,048,000 unit cells on a 32 node Hypercube. For smaller problems, the code produces solutions in a fraction of the time to solve the same problems on sequential computers

Associations of Total and Domain-Specific Sedentary Time With Type 2 Diabetes in Taiwanese Older Adults

Directory of Open Access Journals (Sweden)

Ming-Chun Hsueh

2016-07-01

Full Text Available Background: The increasing prevalence of type 2 diabetes in older adults has become a public health concern. We investigated the associations of total and domain-specific sedentary time with risk of type 2 diabetes in older adults. Methods: The sample comprised 1046 older people (aged ≥65 years. Analyses were performed using crosssectional data collected via computer-assisted telephone-based interviews in 2014. Data on six self-reported domains of sedentary time (Measure of Older Adults’ Sedentary Time, type 2 diabetes status, and sociodemographic variables were included in the study. Binary logistic regression analysis was performed to calculate the adjusted odds ratios (ORs and 95% confidence intervals (CIs for total and individual sedentary behavior components and likelihood of type 2 diabetes. Results: A total of 17.5% of the participants reported type 2 diabetes. No significant associations were found between total sitting time and risk of type 2 diabetes, after controlling for confounding factors. After total sedentary behavior was stratified into six domains, only watching television for more than 2 hours per day was associated with higher odds of type 2 diabetes (OR 1.56; 95% CI, 1.10–2.21, but no significant associations were found between other domains of sedentary behavior (computer use, reading, socializing, transport, and hobbies and risk of type 2 diabetes. Conclusions: These findings suggest that, among domain-specific sedentary behavior, excessive television viewing might increase the risk of type 2 diabetes among older adults more than other forms of sedentary behavior.

A time-domain binaural detection model and its predictions temporal-resolution data

NARCIS (Netherlands)

Breebaart, D.J.; Par, van de S.L.J.D.E.; Kohlrausch, A.G.

2002-01-01

This paper discusses the application of a time-domain binaural signal-detection model in the context of estimates of the temporal resolution of the binaural auditory system. It is demonstrated that the optimal detector which is present in the model is crucial to account for specific temporal

Terahertz time-domain spectroscopy of edible oils

Science.gov (United States)

Dinovitser, Alex; Valchev, Dimitar G.; Abbott, Derek

2017-06-01

Chemical degradation of edible oils has been studied using conventional spectroscopic methods spanning the spectrum from ultraviolet to mid-IR. However, the possibility of morphological changes of oil molecules that can be detected at terahertz frequencies is beginning to receive some attention. Furthermore, the rapidly decreasing cost of this technology and its capability for convenient, in situ measurement of material properties, raises the possibility of monitoring oil during cooking and processing at production facilities, and more generally within the food industry. In this paper, we test the hypothesis that oil undergoes chemical and physical changes when heated above the smoke point, which can be detected in the 0.05-2 THz spectral range, measured using the conventional terahertz time-domain spectroscopy technique. The measurements demonstrate a null result in that there is no significant change in the spectra of terahertz optical parameters after heating above the smoke point for 5 min.

Time-domain soil-structure interaction analysis of nuclear facilities

International Nuclear Information System (INIS)

Coleman, Justin L.; Bolisetti, Chandrakanth; Whittaker, Andrew S.

2016-01-01

The Nuclear Regulatory Commission (NRC) regulation 10 CFR Part 50 Appendix S requires consideration of soil-structure interaction (SSI) in nuclear power plant (NPP) analysis and design. Soil-structure interaction analysis for NPPs is routinely carried out using guidance provided in the ASCE Standard 4-98 titled “Seismic Analysis of Safety-Related Nuclear Structures and Commentary”. This Standard, which is currently under revision, provides guidance on linear seismic soil-structure-interaction (SSI) analysis of nuclear facilities using deterministic and probabilistic methods. A new appendix has been added to the forthcoming edition of ASCE Standard 4 to provide guidance for time-domain, nonlinear SSI (NLSSI) analysis. Nonlinear SSI analysis will be needed to simulate material nonlinearity in soil and/or structure, static and dynamic soil pressure effects on deeply embedded structures, local soil failure at the foundation-soil interface, nonlinear coupling of soil and pore fluid, uplift or sliding of the foundation, nonlinear effects of gaps between the surrounding soil and the embedded structure and seismic isolation systems, none of which can be addressed explicitly at present. Appendix B of ASCE Standard 4 provides general guidance for NLSSI analysis but will not provide a methodology for performing the analysis. This paper provides a description of an NLSSI methodology developed for application to nuclear facilities, including NPPs. This methodology is described as series of sequential steps to produce reasonable results using any time-domain numerical code. These steps require some numerical capabilities, such as nonlinear soil constitutive models, which are also described in the paper.

Results of time-domain electromagnetic soundings in Everglades National Park, Florida

Science.gov (United States)

Fitterman, D.V.; Deszcz-Pan, Maria; Stoddard, C.E.

1999-01-01

This report describes the collection, processing, and interpretation of time-domain electromagnetic soundings from Everglades National Park. The results are used to locate the extent of seawater intrusion in the Biscayne aquifer and to map the base of the Biscayne aquifer in regions where well coverage is sparse. The data show no evidence of fresh, ground-water flows at depth into Florida Bay.

Angular Random Walk Estimation of a Time-Domain Switching Micromachined Gyroscope

Science.gov (United States)

2016-10-19

angular random walk (ARW), bias instability, and scale factor instability. While there are methods to address issues with bias and scale factor...effects. Thus, it is expected that it will have low bias and scale factor instabilities. Simulated ARW performance of a particular incarnation of the...1 2. PARAMETRIC SYSTEM IDENTIFICATION BASED ON TIME-DOMAIN SWITCHING ........ 2 3. FINITE ELEMENT MODELING OF RESONATOR

Helicopter time-domain electromagnetic numerical simulation based on Leapfrog ADI-FDTD

Science.gov (United States)

Guan, S.; Ji, Y.; Li, D.; Wu, Y.; Wang, A.

2017-12-01

We present a three-dimension (3D) Alternative Direction Implicit Finite-Difference Time-Domain (Leapfrog ADI-FDTD) method for the simulation of helicopter time-domain electromagnetic (HTEM) detection. This method is different from the traditional explicit FDTD, or ADI-FDTD. Comparing with the explicit FDTD, leapfrog ADI-FDTD algorithm is no longer limited by Courant-Friedrichs-Lewy(CFL) condition. Thus, the time step is longer. Comparing with the ADI-FDTD, we reduce the equations from 12 to 6 and .the Leapfrog ADI-FDTD method will be easier for the general simulation. First, we determine initial conditions which are adopted from the existing method presented by Wang and Tripp(1993). Second, we derive Maxwell equation using a new finite difference equation by Leapfrog ADI-FDTD method. The purpose is to eliminate sub-time step and retain unconditional stability characteristics. Third, we add the convolution perfectly matched layer (CPML) absorbing boundary condition into the leapfrog ADI-FDTD simulation and study the absorbing effect of different parameters. Different absorbing parameters will affect the absorbing ability. We find the suitable parameters after many numerical experiments. Fourth, We compare the response with the 1-Dnumerical result method for a homogeneous half-space to verify the correctness of our algorithm.When the model contains 107*107*53 grid points, the conductivity is 0.05S/m. The results show that Leapfrog ADI-FDTD need less simulation time and computer storage space, compared with ADI-FDTD. The calculation speed decreases nearly four times, memory occupation decreases about 32.53%. Thus, this algorithm is more efficient than the conventional ADI-FDTD method for HTEM detection, and is more precise than that of explicit FDTD in the late time.

A Model-free Approach to Fault Detection of Continuous-time Systems Based on Time Domain Data

Institute of Scientific and Technical Information of China (English)

Ping Zhang; Steven X. Ding

2007-01-01

In this paper, a model-free approach is presented to design an observer-based fault detection system of linear continuoustime systems based on input and output data in the time domain. The core of the approach is to directly identify parameters of the observer-based residual generator based on a numerically reliable data equation obtained by filtering and sampling the input and output signals.

Time domain diffuse Raman spectrometer based on a TCSPC camera for the depth analysis of diffusive media.

Science.gov (United States)

Konugolu Venkata Sekar, S; Mosca, S; Tannert, S; Valentini, G; Martelli, F; Binzoni, T; Prokazov, Y; Turbin, E; Zuschratter, W; Erdmann, R; Pifferi, A

2018-05-01

We present a time domain diffuse Raman spectrometer for depth probing of highly scattering media. The system is based on, to the best of our knowledge, a novel time-correlated single-photon counting (TCSPC) camera that simultaneously acquires both spectral and temporal information of Raman photons. A dedicated non-contact probe was built, and time domain Raman measurements were performed on a tissue mimicking bilayer phantom. The fluorescence contamination of the Raman signal was eliminated by early time gating (0-212 ps) the Raman photons. Depth sensitivity is achieved by time gating Raman photons at different delays with a gate width of 106 ps. Importantly, the time domain can provide time-dependent depth sensitivity leading to a high contrast between two layers of Raman signal. As a result, an enhancement factor of 2170 was found for our bilayer phantom which is much higher than the values obtained by spatial offset Raman spectroscopy (SORS), frequency offset Raman spectroscopy (FORS), or hybrid FORS-SORS on a similar phantom.

Terahertz time-domain spectroscopy and imaging of artificial RNA

DEFF Research Database (Denmark)

Fischer, Bernd M.; Hoffmann, Matthias; Helm, Hanspeter

2005-01-01

We use terahertz time-domain spectroscopy (THz-TDS) to measure the far-infrared dielectric function of two artificial RNA single strands, composed of polyadenylic acid (poly-A) and polycytidylic acid (poly-C). We find a significant difference in the absorption between the two types of RNA strands......, and we show that we can use this difference to record images of spot arrays of the RNA strands. Under controlled conditions it is possible to use the THz image to distinguish between the two RNA strands. We discuss the requirements to sample preparation imposed by the lack of sharp spectral features...

Time-domain analysis of second-harmonic generation of primary Lamb wave propagation in an elastic plate

International Nuclear Information System (INIS)

Deng Ming-Xi; Xiang Yan-Xun

2010-01-01

Within the second-order perturbation approximation, this paper investigates the physical process of generation of the time-domain second harmonic by a primary Lamb wave waveform in an elastic plate. The present work is performed based on the preconditions that the phase velocity matching is satisfied and that the transfer of energy from the primary Lamb wave to the double frequency Lamb wave is not zero. It investigates the influences of the difference between the group velocities of the primary Lamb wave and the double frequency Lamb wave, the propagation distance and the duration of the primary Lamb wave waveform on the envelope shape of the time-domain second harmonic. It finds that the maximum magnitude of the envelope of the second-harmonic waveform can grow within some propagation distance even if the condition of group velocity matching is not satisfied. Our analyses also indicate that the maximum magnitude of the envelope of the second-harmonic waveform is kept constant beyond a specific propagation distance. Furthermore, it concludes that the integration amplitude of the time-domain second-harmonic waveform always grows with propagation distance within the second-order perturbation. The present research yields new physical insight not previously available into the effect of generation of the time-domain second harmonic by propagation of a primary Lamb wave waveform

Coil response inversion for very early time modelling of helicopter-borne time-domain electromagnetic data and mapping of near-surface geological layers

DEFF Research Database (Denmark)

Schamper, Cyril Noel Clarence; Auken, Esben; Sørensen, Kurt Ingvard K.I.

2014-01-01

Very early times in the order of 2-3 μs from the end of the turn-off ramp for time-domain electromagnetic systems are crucial for obtaining a detailed resolution of the near-surface geology in the depth interval 0-20 m. For transient electromagnetic systems working in the off time, an electric cu...... resolution of shallow geological layers in the depth interval 0-20 m. This is proved by comparing results from the airborne electromagnetic survey to more than 100 km of Electrical Resistivity Tomography measured with 5 m electrode spacing.......Very early times in the order of 2-3 μs from the end of the turn-off ramp for time-domain electromagnetic systems are crucial for obtaining a detailed resolution of the near-surface geology in the depth interval 0-20 m. For transient electromagnetic systems working in the off time, an electric...

Clock-distribution with instantaneous synchronisation for 160 Gbit/s optical time-domain multiplexed packet transmission

NARCIS (Netherlands)

Gomez-Agis, F.; Calabretta, N.; Albores Mejia, A.; Dorren, H.J.S.

2010-01-01

We demonstrate for the first time, to our knowledge, a clock-distribution method for ultra-high-speed optical time-domain multiplexed systems data packets that provides instantaneous synchronization, fast locking/unlocking times, and a highly stable bursty clock, enabling error-free operation of 160

An explicit marching on-in-time solver for the time domain volume magnetic field integral equation

KAUST Repository

Sayed, Sadeed Bin

2014-07-01

Transient scattering from inhomogeneous dielectric objects can be modeled using time domain volume integral equations (TDVIEs). TDVIEs are oftentimes solved using marching on-in-time (MOT) techniques. Classical MOT-TDVIE solvers expand the field induced on the scatterer using local spatio-temporal basis functions. Inserting this expansion into the TDVIE and testing the resulting equation in space and time yields a system of equations that is solved by time marching. Depending on the type of the basis and testing functions and the time step, the time marching scheme can be implicit (N. T. Gres, et al., Radio Sci., 36(3), 379-386, 2001) or explicit (A. Al-Jarro, et al., IEEE Trans. Antennas Propag., 60(11), 5203-5214, 2012). Implicit MOT schemes are known to be more stable and accurate. However, under low-frequency excitation, i.e., when the time step size is large, they call for inversion of a full matrix system at very time step.

An explicit marching on-in-time solver for the time domain volume magnetic field integral equation

KAUST Repository

Sayed, Sadeed Bin; Ulku, Huseyin Arda; Bagci, Hakan

2014-01-01

Transient scattering from inhomogeneous dielectric objects can be modeled using time domain volume integral equations (TDVIEs). TDVIEs are oftentimes solved using marching on-in-time (MOT) techniques. Classical MOT-TDVIE solvers expand the field induced on the scatterer using local spatio-temporal basis functions. Inserting this expansion into the TDVIE and testing the resulting equation in space and time yields a system of equations that is solved by time marching. Depending on the type of the basis and testing functions and the time step, the time marching scheme can be implicit (N. T. Gres, et al., Radio Sci., 36(3), 379-386, 2001) or explicit (A. Al-Jarro, et al., IEEE Trans. Antennas Propag., 60(11), 5203-5214, 2012). Implicit MOT schemes are known to be more stable and accurate. However, under low-frequency excitation, i.e., when the time step size is large, they call for inversion of a full matrix system at very time step.

Broadband time domain acoustic holography based on the discrete orthonormal S-transform

NARCIS (Netherlands)

Zhou, H.; Lopez Arteaga, I.; Nijmeijer, H.; Lim, Kian Meng

2015-01-01

The purpose of this paper is to deal with the problem of nonstationary broadband sound fields more efficiently. A basis function of the discrete orthonormal S-transform (DOST) is used to analyze the measured signal. With respect to the time domain signal in a certain band, DOST leads to a

320 Gb/s Nyquist OTDM received by polarization-insensitive time-domain OFT

DEFF Research Database (Denmark)

Hu, Hao; Kong, Deming; Palushani, Evarist

2014-01-01

We have demonstrated the generation of a 320 Gb/s Nyquist-OTDM signal by rectangular filtering on an RZ-OTDM signal with the filter bandwidth (320 GHz) equal to the baud rate (320 Gbaud) and the reception of such a Nyquist-OTDM signal using polarization-insensitive time-domain optical Fourier tra...

Mapping geological structures in bedrock via large-scale direct current resistivity and time-domain induced polarization tomography

DEFF Research Database (Denmark)

Rossi, Matteo; Olsson, Per-Ivar; Johansson, Sara

2017-01-01

-current resistivity distribution of the subsoil and the phase of the complex conductivity using a constant-phase angle model. The joint interpretation of electrical resistivity and induced-polarization models leads to a better understanding of complex three-dimensional subsoil geometries. The results have been......An investigation of geological conditions is always a key point for planning infrastructure constructions. Bedrock surface and rock quality must be estimated carefully in the designing process of infrastructures. A large direct-current resistivity and time-domain induced-polarization survey has......, there are northwest-trending Permian dolerite dykes that are less deformed. Four 2D direct-current resistivity and time-domain induced-polarization profiles of about 1-km length have been carefully pre-processed to retrieve time-domain induced polarization responses and inverted to obtain the direct...

Measurement and analysis of time-domain characteristics of corona-generated radio interference from a single positive corona source

Science.gov (United States)

Li, Xuebao; Li, Dayong; Chen, Bo; Cui, Xiang; Lu, Tiebing; Li, Yinfei

2018-04-01

The corona-generated electromagnetic interference commonly known as radio interference (RI) has become a limiting factor for the design of high voltage direct current transmission lines. In this paper, a time-domain measurement system is developed to measure the time-domain characteristics of corona-generated RI from a single corona source under a positive corona source. In the experiments, the corona current pulses are synchronously measured through coupling capacitors. The one-to-one relationship between the corona current pulse and measured RI voltage pulse is observed. The statistical characteristics of pulse parameters are analyzed, and the correlations between the corona current pulse and RI voltage pulse in the time-domain and frequency-domain are analyzed. Depending on the measured corona current pulses, the time-domain waveform of corona-generated RI is calculated on the basis of the propagation model of corona current on the conductor, the dipolar model for electric field calculation, and the antenna model for inducing voltage calculation. The well matched results between measured and simulated waveforms of RI voltage can show the validity of the measurement and calculation method presented in this paper, which also further show the close correlation between corona current and corona-generated RI.

Nonlinear time-domain cochlear model for transient stimulation and human otoacoustic emission

DEFF Research Database (Denmark)

Verhulst, Sarah; Dau, Torsten; Shera, Christopher A.

2012-01-01

This paper describes the implementation and performance of a nonlinear time-domain model of the cochlea for transient stimulation and human otoacoustic emission generation. The nonlinearity simulates compressive growth of measured basilar-membrane impulse responses. The model accounts...... for reflection and distortion-source otoacoustic emissions (OAEs) and simulates spontaneous OAEs through manipulation of the middle-ear reflectance. The model was calibrated using human psychoacoustical and otoacoustic tuning parameters. It can be used to investigate time-dependent properties of cochlear...

Experimentally achieving borehole antenna radar directivity in the time domain in the presence of strong mutual coupling

CSIR Research Space (South Africa)

Vogt, D

2008-06-01

Full Text Available published borehole radar antennas have achieved directivity by post processing data received in the frequency domain, or by constructing an aperture antenna, where borehole dimensions allowed this. In this paper, a time-domain technique is investigated...

Estimating primary production from oxygen time series: A novel approach in the frequency domain

NARCIS (Netherlands)

Cox, T.J.S.; Maris, T.; Soetaert, K.; Kromkamp, J.C.; Meire, P.; Meysman, F.J.R.

2015-01-01

Based on an analysis in the frequency domain of the governing equation of oxygen dynamics in aquatic systems, we derive a new method for estimating gross primary production (GPP) from oxygen time series. The central result of this article is a relation between time averaged GPP and the amplitude of

Scattering analysis of periodic structures using finite-difference time-domain

CERN Document Server

ElMahgoub, Khaled; Elsherbeni, Atef Z

2012-01-01

Periodic structures are of great importance in electromagnetics due to their wide range of applications such as frequency selective surfaces (FSS), electromagnetic band gap (EBG) structures, periodic absorbers, meta-materials, and many others. The aim of this book is to develop efficient computational algorithms to analyze the scattering properties of various electromagnetic periodic structures using the finite-difference time-domain periodic boundary condition (FDTD/PBC) method. A new FDTD/PBC-based algorithm is introduced to analyze general skewed grid periodic structures while another algor

Time-domain incomplete Gauss-Newton full-waveform inversion of Gulf of Mexico data

KAUST Repository

AlTheyab, Abdullah

2013-09-22

We apply the incomplete Gauss-Newton full-waveform inversion (TDIGN-FWI) to Gulf of Mexico (GOM) data in the space-time domain. In our application, iterative least-squares reverse-time migration (LSRTM) is used to estimate the model update at each non-linear iteration, and the number of LSRTM iterations is progressively increased after each non-linear iteration. With this method, model updating along deep reflection wavepaths are automatically enhanced, which in turn improves imaging below the reach of diving-waves. The forward and adjoint operators are implemented in the space-time domain to simultaneously invert the data over a range of frequencies. A multiscale approach is used where higher frequencies are down-weighted significantly at early iterations, and gradually included in the inversion. Synthetic data results demonstrate the effectiveness of reconstructing both the high- and low-wavenumber features in the model without relying on diving waves in the inversion. Results with Gulf of Mexico field data show a significantly improved migration image in both the shallow and deep sections.

Domain Decomposition Solvers for Frequency-Domain Finite Element Equations

KAUST Repository

Copeland, Dylan

2010-10-05

The paper is devoted to fast iterative solvers for frequency-domain finite element equations approximating linear and nonlinear parabolic initial boundary value problems with time-harmonic excitations. Switching from the time domain to the frequency domain allows us to replace the expensive time-integration procedure by the solution of a simple linear elliptic system for the amplitudes belonging to the sine- and to the cosine-excitation or a large nonlinear elliptic system for the Fourier coefficients in the linear and nonlinear case, respectively. The fast solution of the corresponding linear and nonlinear system of finite element equations is crucial for the competitiveness of this method. © 2011 Springer-Verlag Berlin Heidelberg.

Domain Decomposition Solvers for Frequency-Domain Finite Element Equations

KAUST Repository

Copeland, Dylan; Kolmbauer, Michael; Langer, Ulrich

2010-01-01

The paper is devoted to fast iterative solvers for frequency-domain finite element equations approximating linear and nonlinear parabolic initial boundary value problems with time-harmonic excitations. Switching from the time domain to the frequency domain allows us to replace the expensive time-integration procedure by the solution of a simple linear elliptic system for the amplitudes belonging to the sine- and to the cosine-excitation or a large nonlinear elliptic system for the Fourier coefficients in the linear and nonlinear case, respectively. The fast solution of the corresponding linear and nonlinear system of finite element equations is crucial for the competitiveness of this method. © 2011 Springer-Verlag Berlin Heidelberg.

Solution of the Burgers Equation in the Time Domain

Directory of Open Access Journals (Sweden)

M. Bednařík

2002-01-01

Full Text Available This paper deals with a theoretical description of the propagation of a finite amplitude acoustic waves. The theory based on the homogeneous Burgers equation of the second order of accuracy is presented here. This equation takes into account both nonlinear effects and dissipation. The method for solving this equation, using the well-known Cole-Hopf transformation, is presented. Two methods for numerical solution of these equations in the time domain are presented. The first is based on the simple Simpson method, which is suitable for smaller Goldberg numbers. The second uses the more advanced saddle point method, and is appropriate for large Goldberg numbers.

Detection of Poisonous Herbs by Terahertz Time-Domain Spectroscopy

Science.gov (United States)

Zhang, H.; Li, Z.; Chen, T.; Liu, J.-J.

2018-03-01

The aim of this paper is the application of terahertz (THz) spectroscopy combined with chemometrics techniques to distinguish poisonous and non-poisonous herbs which both have a similar appearance. Spectra of one poisonous and two non-poisonous herbs (Gelsemium elegans, Lonicera japonica Thunb, and Ficus Hirta Vahl) were obtained in the range 0.2-1.4 THz by using a THz time-domain spectroscopy system. Principal component analysis (PCA) was used for feature extraction. The prediction accuracy of classification is between 97.78 to 100%. The results demonstrate an efficient and applicative method to distinguish poisonous herbs, and it may be implemented by using THz spectroscopy combined with chemometric algorithms.

The element level time domain (ELTD) method for the analysis of nano-optical systems: I. Nondispersive media

Science.gov (United States)

Fallahi, Arya; Oswald, Benedikt; Leidenberger, Patrick

2012-04-01

We study a 3-dimensional, dual-field, fully explicit method for the solution of Maxwell's equations in the time domain on unstructured, tetrahedral grids. The algorithm uses the element level time domain (ELTD) discretization of the electric and magnetic vector wave equations. In particular, the suitability of the method for the numerical analysis of nanometer structured systems in the optical region of the electromagnetic spectrum is investigated. The details of the theory and its implementation as a computer code are introduced and its convergence behavior as well as conditions for stable time domain integration is examined. Here, we restrict ourselves to non-dispersive dielectric material properties since dielectric dispersion will be treated in a subsequent paper. Analytically solvable problems are analyzed in order to benchmark the method. Eventually, a dielectric microlens is considered to demonstrate the potential of the method. A flexible method of 2nd order accuracy is obtained that is applicable to a wide range of nano-optical configurations and can be a serious competitor to more conventional finite difference time domain schemes which operate only on hexahedral grids. The ELTD scheme can resolve geometries with a wide span of characteristic length scales and with the appropriate level of detail, using small tetrahedra where delicate, physically relevant details must be modeled.

Time-domain calculation of sub-nanosecond pulse launched by a proton beam

International Nuclear Information System (INIS)

Chan, Kwok-Chi Dominic; Cooper, R.K.

1990-01-01

Using the finite-difference time-domain code TBCI, we have numerically calculated the radiation from a sub-nanosecond 800-MeV proton bunch as it is launched into space. The calculation is compared to measurements of the time history of the radiated fields and good agreement is found. A movie showing the development of the radiation pattern will be shown during the presentation at this conference, namely, the First Los Alamos Symposium on Ultra-Wideband Radar. 6 refs., 7 figs

Plastique: A synchrotron radiation beamline for time resolved fluorescence in the frequency domain

Science.gov (United States)

De Stasio, Gelsomina; Zema, N.; Antonangeli, F.; Savoia, A.; Parasassi, T.; Rosato, N.

1991-06-01

PLASTIQUE is the only synchrotron radiation beamline in the world that performs time resolved fluorescence experiments in frequency domain. These experiments are extremely valuable sources of information on the structure and dynamics of molecules. We describe the beamline and some initial data.

Nucleation of holin domains and holes optimizes lysis timing of E. coli by phage λ

Science.gov (United States)

Ryan, Gillian; Rutenberg, Andrew

2007-03-01

Holin proteins regulate the precise scheduling of Escherichia coli lysis during infection by bacteriophage λ. Inserted into the host bacterium's inner membrane during infection, holins aggregate to form rafts and then holes within those rafts. We present a two-stage nucleation model of holin action, with the nucleation of condensed holin domains followed by the nucleation of holes within these domains. Late nucleation of holin rafts leads to a weak dependence of lysis timing on host cell size, though both nucleation events contribute equally to timing errors. Our simulations recover the accurate scheduling observed experimentally, and also suggest that phage-λ lysis of E.coli is optimized.

Spectral domain OCT versus time domain OCT in the evaluation of macular features related to wet age-related macular degeneration

Directory of Open Access Journals (Sweden)

Isola V

2012-02-01

Full Text Available Luisa Pierro1, Elena Zampedri1, Paolo Milani2, Marco Gagliardi1, Vincenzo Isola2, Alfredo Pece21Department of Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milano, Italy, 2Fondazione Retina 3000, Milano, ItalyBackground: The aim of this study was to compare the agreement between spectral domain optical coherence tomography (SD OCT and time domain stratus OCT (TD OCT in evaluating macular morphology alterations in wet age-related macular degeneration (AMD.Methods: This retrospective study was performed on 77 eyes of 77 patients with primary or recurring subfoveal choroidal neovascularization secondary to AMD. All patients underwent OCT examination using Zeiss Stratus OCT 3 (Carl Zeiss Meditec Inc, Dublin, CA and Opko OTI Spectral SLO/OCT (Ophthalmic Technologies Inc, Toronto, Canada. In all radial line scans, the presence of intraretinal edema (IRE, serous pigment epithelium detachment (sPED, neurosensory serous retinal detachment (NSRD, epiretinal membrane (EM, inner limiting membrane thickening (ILMT, and hard exudates (HE were evaluated. The degree of matching was quantified by Kappa measure of agreement.Results: The percentage distribution of TD OCT findings versus SD OCT findings was: IRE 36.3% versus 77.9%, sPED 57.1% versus 85.7%, NSRD 38.9% versus 53.2%, EM 10.5% versus 26.3%, ILMT 3.8% versus 32.4%, and HE 6.4% versus 54.5%. The agreement was as follows: sPED: kappa value 0.15; NSRD: kappa value 0.61; IRE: kappa value 0.18; EM: kappa value 0.41; ILMT: kappa value 0.02; HE: kappa value 0.06.Conclusion: The agreement in the evaluation of macular lesions between the two techniques is poor and depends on the lesion considered. SD OCT allows better detection of the alterations typically related to choroidal neovascularization such as IRE, PED, ILM thickening, and HE. Consequently its use should be strongly considered in patients with wet AMD.Keywords: spectral domain, OCT, time domain, macular degeneration, AMD

openPSTD: The open source pseudospectral time-domain method for acoustic propagation

Science.gov (United States)

Hornikx, Maarten; Krijnen, Thomas; van Harten, Louis

2016-06-01

An open source implementation of the Fourier pseudospectral time-domain (PSTD) method for computing the propagation of sound is presented, which is geared towards applications in the built environment. Being a wave-based method, PSTD captures phenomena like diffraction, but maintains efficiency in processing time and memory usage as it allows to spatially sample close to the Nyquist criterion, thus keeping both the required spatial and temporal resolution coarse. In the implementation it has been opted to model the physical geometry as a composition of rectangular two-dimensional subdomains, hence initially restricting the implementation to orthogonal and two-dimensional situations. The strategy of using subdomains divides the problem domain into local subsets, which enables the simulation software to be built according to Object-Oriented Programming best practices and allows room for further computational parallelization. The software is built using the open source components, Blender, Numpy and Python, and has been published under an open source license itself as well. For accelerating the software, an option has been included to accelerate the calculations by a partial implementation of the code on the Graphical Processing Unit (GPU), which increases the throughput by up to fifteen times. The details of the implementation are reported, as well as the accuracy of the code.

Imaging gene expression in real-time using aptamers

Energy Technology Data Exchange (ETDEWEB)

Shin, Il Chung [Iowa State Univ., Ames, IA (United States)

2011-01-01

Signal transduction pathways are usually activated by external stimuli and are transient. The downstream changes such as transcription of the activated genes are also transient. Real-time detection of promoter activity is useful for understanding changes in gene expression, especially during cell differentiation and in development. A simple and reliable method for viewing gene expression in real time is not yet available. Reporter proteins such as fluorescent proteins and luciferase allow for non-invasive detection of the products of gene expression in living cells. However, current reporter systems do not provide for real-time imaging of promoter activity in living cells. This is because of the long time period after transcription required for fluorescent protein synthesis and maturation. We have developed an RNA reporter system for imaging in real-time to detect changes in promoter activity as they occur. The RNA reporter uses strings of RNA aptamers that constitute IMAGEtags (Intracellular MultiAptamer GEnetic tags), which can be expressed from a promoter of choice. The tobramycin, neomycin and PDC RNA aptamers have been utilized for this system and expressed in yeast from the GAL1 promoter. The IMAGEtag RNA kinetics were quantified by RT-qPCR. In yeast precultured in raffinose containing media the GAL1 promoter responded faster than in yeast precultured in glucose containing media. IMAGEtag RNA has relatively short half-life (5.5 min) in yeast. For imaging, the yeast cells are incubated with their ligands that are labeled with fluorescent dyes. To increase signal to noise, ligands have been separately conjugated with the FRET (Förster resonance energy transfer) pairs, Cy3 and Cy5. With these constructs, the transcribed aptamers can be imaged after activation of the promoter by galactose. FRET was confirmed with three different approaches, which were sensitized emission, acceptor photobleaching and donor lifetime by FLIM (fluorescence lifetime imaging

Imaging gene expression in real-time using aptamers

Energy Technology Data Exchange (ETDEWEB)

Shin, Ilchung [Iowa State Univ., Ames, IA (United States)

2012-01-01

Signal transduction pathways are usually activated by external stimuli and are transient. The downstream changes such as transcription of the activated genes are also transient. Real-time detection of promoter activity is useful for understanding changes in gene expression, especially during cell differentiation and in development. A simple and reliable method for viewing gene expression in real time is not yet available. Reporter proteins such as fluorescent proteins and luciferase allow for non-invasive detection of the products of gene expression in living cells. However, current reporter systems do not provide for real-time imaging of promoter activity in living cells. This is because of the long time period after transcription required for fluorescent protein synthesis and maturation. We have developed an RNA reporter system for imaging in real-time to detect changes in promoter activity as they occur. The RNA reporter uses strings of RNA aptamers that constitute IMAGEtags (Intracellular MultiAptamer GEnetic tags), which can be expressed from a promoter of choice. The tobramycin, neomycin and PDC RNA aptamers have been utilized for this system and expressed in yeast from the GAL1 promoter. The IMAGEtag RNA kinetics were quantified by RT-qPCR. In yeast precultured in raffinose containing media the GAL1 promoter responded faster than in yeast precultured in glucose containing media. IMAGEtag RNA has relatively short half-life (5.5 min) in yeast. For imaging, the yeast cells are incubated with their ligands that are labeled with fluorescent dyes. To increase signal to noise, ligands have been separately conjugated with the FRET (Förster resonance energy transfer) pairs, Cy3 and Cy5. With these constructs, the transcribed aptamers can be imaged after activation of the promoter by galactose. FRET was confirmed with three different approaches, which were sensitized emission, acceptor photobleaching and donor lifetime by FLIM (fluorescence lifetime imaging

Accurate characterization of 3D diffraction gratings using time domain discontinuous Galerkin method with exact absorbing boundary conditions

KAUST Repository

Sirenko, Kostyantyn

2013-07-01

Exact absorbing and periodic boundary conditions allow to truncate grating problems\\' infinite physical domains without introducing any errors. This work presents exact absorbing boundary conditions for 3D diffraction gratings and describes their discretization within a high-order time-domain discontinuous Galerkin finite element method (TD-DG-FEM). The error introduced by the boundary condition discretization matches that of the TD-DG-FEM; this results in an optimal solver in terms of accuracy and computation time. Numerical results demonstrate the superiority of this solver over TD-DG-FEM with perfectly matched layers (PML)-based domain truncation. © 2013 IEEE.

Impact of time-domain IP pulse length on measured data and inverted models

DEFF Research Database (Denmark)

Olsson, P. I.; Fiandaca, G.; Dahlin, T.

2015-01-01

The duration of time domain (TD) induced polarization (IP) current injections has significant impact on the acquired IP data as well as on the inversion models, if the standard evaluation procedure is followed. However, it is still possible to retrieve similar inversion models if the waveform...... of the injected current and the IP response waveform are included in the inversion. The on-time also generally affects the signal-tonoise ratio (SNR) where an increased on-time gives higher SNR for the IP data....

Full Wave Analysis of Passive Microwave Monolithic Integrated Circuit Devices Using a Generalized Finite Difference Time Domain (GFDTD) Algorithm

Science.gov (United States)

Lansing, Faiza S.; Rascoe, Daniel L.

1993-01-01

This paper presents a modified Finite-Difference Time-Domain (FDTD) technique using a generalized conformed orthogonal grid. The use of the Conformed Orthogonal Grid, Finite Difference Time Domain (GFDTD) enables the designer to match all the circuit dimensions, hence eliminating a major source o error in the analysis.

Marching on-in-time solution of the time domain magnetic field integral equation using a predictor-corrector scheme

KAUST Repository

Ulku, Huseyin Arda; Bagci, Hakan; Michielssen, Eric

2013-01-01

An explicit marching on-in-time (MOT) scheme for solving the time-domain magnetic field integral equation (TD-MFIE) is presented. The proposed MOT-TD-MFIE solver uses Rao-Wilton-Glisson basis functions for spatial discretization and a PE(CE)m-type linear multistep method for time marching. Unlike previous explicit MOT-TD-MFIE solvers, the time step size can be chosen as large as that of the implicit MOT-TD-MFIE solvers without adversely affecting accuracy or stability. An algebraic stability analysis demonstrates the stability of the proposed explicit solver; its accuracy and efficiency are established via numerical examples. © 1963-2012 IEEE.

Marching on-in-time solution of the time domain magnetic field integral equation using a predictor-corrector scheme

KAUST Repository

Ulku, Huseyin Arda

2013-08-01

An explicit marching on-in-time (MOT) scheme for solving the time-domain magnetic field integral equation (TD-MFIE) is presented. The proposed MOT-TD-MFIE solver uses Rao-Wilton-Glisson basis functions for spatial discretization and a PE(CE)m-type linear multistep method for time marching. Unlike previous explicit MOT-TD-MFIE solvers, the time step size can be chosen as large as that of the implicit MOT-TD-MFIE solvers without adversely affecting accuracy or stability. An algebraic stability analysis demonstrates the stability of the proposed explicit solver; its accuracy and efficiency are established via numerical examples. © 1963-2012 IEEE.

Non-linear wave loads and ship responses by a time-domain strip theory

DEFF Research Database (Denmark)

Xia, Jinzhu; Wang, Zhaohui; Jensen, Jørgen Juncher

1998-01-01

. Based on this time-domain strip theory, an efficient non-linear hydroelastic method of wave- and slamming-induced vertical motions and structural responses of ships is developed, where the structure is represented as a Timoshenko beam. Numerical calculations are presented for the S175 Containership...

Non-Linear Wave Loads and Ship responses by a time-domain Strip Theory

DEFF Research Database (Denmark)

Xia, Jinzhu; Wang, Zhaohui; Jensen, Jørgen Juncher

1998-01-01

. Based on this time-domain strip theory, an efficient non-linear hyroelastic method of wave- and slamming-induced vertical motions and structural responses of ships is developed, where the structure is represented by the Timoshenko beam theory. Numerical calculations are presented for the S175...

PLASTIQUE: A synchrotron radiation beamline for time resolved fluorescence in the frequency domain

International Nuclear Information System (INIS)

De Stasio, G.; Zema, N.; Antonangeli, F.; Parasassi, T.; Rosato, N.

1991-01-01

PLASTIQUE is the only synchrotron radiation beamline in the world that performs time resolved fluorescence experiments in the frequency domain. These experiments are extremely valuable sources of informations on the structure and dynamics of molecules. The beamline and some examples of initial data are described

Fra Angelico’s painting technique revealed by terahertz time-domain imaging (THz-TDI)

DEFF Research Database (Denmark)

Dandolo, Corinna Ludovica Koch; Picollo, Marcello; Cucci, Costanza

2016-01-01

We have investigated with terahertz time-domain imaging (THz-TDI) the well-known Lamentation over the dead Christ panel painting (San Marco Museum, Florence) painted by Fra Giovanni Angelico within 1436 and 1441. The investigation provided a better understanding of the construction and gilding te...

A comparison of helicopter-borne electromagnetics in frequency- and time-domain at the Cuxhaven valley in Northern Germany

DEFF Research Database (Denmark)

Steuner, Annika; Siemon, Bernhard; Auken, Esben

2010-01-01

Two different airborne electromagnetic methods were applied in the same area: the frequency-domain helicopter-borne electromagnetic (HEM)system operated by the Federal Institute for Geosciences and Natural Resources, Germany, and the time-domain SkyTEM system of theHydroGeophysics Group at the Un......Two different airborne electromagnetic methods were applied in the same area: the frequency-domain helicopter-borne electromagnetic (HEM)system operated by the Federal Institute for Geosciences and Natural Resources, Germany, and the time-domain SkyTEM system of theHydroGeophysics Group...... at the University of Aarhus, Denmark. For verification of and comparison with the airborne methods, ground-basedtransient electromagnetics and 2-D resistivity surveying were carried out. The target of investigation was the Cuxhaven valley in NorthernGermany, which is a significant local groundwater reservoir...

Time coordination of heterogeneous distance protections using a domain specific language

OpenAIRE

Marcin Kowalski; Jan Magott

2012-01-01

BACKGROUND: Distance protections are widely used in protection of energy transmission lines, but their time coordination is still an important and difficult problem. Inappropriate configuration leads to a hazard event: remote circuit breaker tripping provided the local circuit breaker can be opened, which severely impairs power system operation.OBJECTIVE: To describe a method and provide software tools to alleviate the hazard in power systems.METHODS: A domain specific language (DSL) for repr...

Time-domain representation of frequency dependent inertial forces on offshore structures

DEFF Research Database (Denmark)

Krenk, Steen

2013-01-01

dependence is then approximated by a rational function, corresponding to a set of ordinary differential equations in the time domain. The MacCamy-Fuchs solution leads to a representation of the inertial force coefficient as a complex function with argument mainly corresponding to a 'phase lead', in contrast...... history of the inertial force is determined by processing the stable part of the transformation by a forward time integration, followed by an integration in the negative time-direction to obtain the final inertial force time history. The differential equations of the local inertial force at a cross......The inertial wave force on a vertical cylinder decreases with decreasing wave length, when the wave length is less than about six times the diameter of the diameter of the cylinder. In structures with a largediameter component like mono-towers the resonance frequency of the structure is typically...

Endothermic decompositions of inorganic monocrystalline thin plates. I. Shape of polycrystalline product domains versus constraints and time

Science.gov (United States)

Bertrand, G.; Comperat, M.; Lallemant, M.; Watelle, G.

1980-03-01

Copper sulfate pentahydrate dehydration into trihydrate was investigated using monocrystalline platelets with varying crystallographic orientations. The morphological and kinetic features of the trihydrate domains were examined. Different shapes were observed: polygons (parallelograms, hexagons) and ellipses; their conditions of occurrence are reported in the (P, T) diagram. At first (for about 2 min), the ratio of the long to the short axes of elliptical domains changes with time; these subsequently develop homothetically and the rate ratio is then only pressure dependent. Temperature influence is inferred from that of pressure. Polygonal shapes are time dependent and result in ellipses. So far, no model can be put forward. Yet, qualitatively, the polygonal shape of a domain may be explained by the prevalence of the crystal arrangement and the elliptical shape by that of the solid tensorial properties. The influence of those factors might be modulated versus pressure, temperature, interface extent, and, thus, time.

De novo identification of replication-timing domains in the human genome by deep learning.

Science.gov (United States)

Liu, Feng; Ren, Chao; Li, Hao; Zhou, Pingkun; Bo, Xiaochen; Shu, Wenjie

2016-03-01

The de novo identification of the initiation and termination zones-regions that replicate earlier or later than their upstream and downstream neighbours, respectively-remains a key challenge in DNA replication. Building on advances in deep learning, we developed a novel hybrid architecture combining a pre-trained, deep neural network and a hidden Markov model (DNN-HMM) for the de novo identification of replication domains using replication timing profiles. Our results demonstrate that DNN-HMM can significantly outperform strong, discriminatively trained Gaussian mixture model-HMM (GMM-HMM) systems and other six reported methods that can be applied to this challenge. We applied our trained DNN-HMM to identify distinct replication domain types, namely the early replication domain (ERD), the down transition zone (DTZ), the late replication domain (LRD) and the up transition zone (UTZ), using newly replicated DNA sequencing (Repli-Seq) data across 15 human cells. A subsequent integrative analysis revealed that these replication domains harbour unique genomic and epigenetic patterns, transcriptional activity and higher-order chromosomal structure. Our findings support the 'replication-domain' model, which states (1) that ERDs and LRDs, connected by UTZs and DTZs, are spatially compartmentalized structural and functional units of higher-order chromosomal structure, (2) that the adjacent DTZ-UTZ pairs form chromatin loops and (3) that intra-interactions within ERDs and LRDs tend to be short-range and long-range, respectively. Our model reveals an important chromatin organizational principle of the human genome and represents a critical step towards understanding the mechanisms regulating replication timing. Our DNN-HMM method and three additional algorithms can be freely accessed at https://github.com/wenjiegroup/DNN-HMM The replication domain regions identified in this study are available in GEO under the accession ID GSE53984. shuwj@bmi.ac.cn or boxc

Time domain-nuclear magnetic resonance study of chars from southern hardwoods

International Nuclear Information System (INIS)

Elder, Thomas; Labbe, Nicole; Harper, David; Rials, Timothy

2006-01-01

Chars from the thermal degradation of silver maple (Acer saccharinum), red maple (Acer rubrum), sugar maple (Acer saccharum), and white oak (Quercus spp.), performed at temperatures from 250 to 350 o C, were examined using time domain-nuclear magnetic resonance spectroscopy. Prior to analysis, the chars were equilibrated under conditions insuring the presence of bound water only and both bound water and free water. Transverse relaxation times were found to be related to the moisture content of the chars, which varied with temperature. At elevated temperatures the number of signals assigned to free water decreased, indicative of an increase in pore size within the chars

Time domain oscillating poles: Stability redefined in Memristor based Wien-oscillators

KAUST Repository

Talukdar, Abdul Hafiz Ibne

2012-07-28

Traditionally, the necessary and sufficient condition for any system to be oscillating is that its poles are located on the imaginary (jω) axis. In this paper, for the first time, we have shown that systems can oscillate with time-domain oscillating poles. The idea is verified using a Memristor based Wien oscillator. Sustained oscillations are observed without having the poles of the system fixed on the imaginary axis and the oscillating behavior of the system poles is reported. The oscillating resistance and triangular shape of FFT are also demonstrated with mathematical reasoning and simulation results to support the unusual and surprising characteristics. © 2009 IEEE.

Time-domain full waveform inversion using the gradient preconditioning based on transmitted waves energy

KAUST Repository

Zhang, Xiao-bo; Tan, Jun; Song, Peng; Li, Jin-shan; Xia, Dong-ming; Liu, Zhao-lun

2017-01-01

The gradient preconditioning approach based on seismic wave energy can effectively avoid the huge storage consumption in the gradient preconditioning algorithms based on Hessian matrices in time-domain full waveform inversion (FWI), but the accuracy

Modern linear control design a time-domain approach

CERN Document Server

Caravani, Paolo

2013-01-01

This book offers a compact introduction to modern linear control design.  The simplified overview presented of linear time-domain methodology paves the road for the study of more advanced non-linear techniques. Only rudimentary knowledge of linear systems theory is assumed - no use of Laplace transforms or frequency design tools is required. Emphasis is placed on assumptions and logical implications, rather than abstract completeness; on interpretation and physical meaning, rather than theoretical formalism; on results and solutions, rather than derivation or solvability.  The topics covered include transient performance and stabilization via state or output feedback; disturbance attenuation and robust control; regional eigenvalue assignment and constraints on input or output variables; asymptotic regulation and disturbance rejection. Lyapunov theory and Linear Matrix Inequalities (LMI) are discussed as key design methods. All methods are demonstrated with MATLAB to promote practical use and comprehension. ...

Computational electrodynamics the finite-difference time-domain method

CERN Document Server

Taflove, Allen

2005-01-01

This extensively revised and expanded third edition of the Artech House bestseller, Computational Electrodynamics: The Finite-Difference Time-Domain Method, offers engineers the most up-to-date and definitive resource on this critical method for solving Maxwell's equations. The method helps practitioners design antennas, wireless communications devices, high-speed digital and microwave circuits, and integrated optical devices with unsurpassed efficiency. There has been considerable advancement in FDTD computational technology over the past few years, and the third edition brings professionals the very latest details with entirely new chapters on important techniques, major updates on key topics, and new discussions on emerging areas such as nanophotonics. What's more, to supplement the third edition, the authors have created a Web site with solutions to problems, downloadable graphics and videos, and updates, making this new edition the ideal textbook on the subject as well.

Differentiation of illicit drugs with THz time-domain spectroscopy

International Nuclear Information System (INIS)

Liu Guifeng; Ma Shihua; Ji Te; Zhao Hongwei; Wang Wenfeng

2010-01-01

The tera hertz time-domain spectroscopy (THz-TDS) was used for sensing and identifying illicit drugs. The absorption spectra of seven illicit drug samples(morphine and its hydrochloride, cocaine hydrochloride, codeine phosphate, papaverine hydrochloride, pethidine hydrochloride, and thebaine) were studied by THz-TDS at 0.3-2.0 THz at room temperature. The geometric structure and vibration frequencies of morphine were calculated by density functional theory. The four absorption features were dominated by intra-/inter-molecular collective or lattice vibration modes. Each illicit drug has a distinct signature in its THz spectra. The results indicate that the THz-TDS can be used to identify and discriminate illicit drugs by their characteristic fingerprints. (authors)

Terahertz Time Domain Spectroscopy for Structure-II Gas Hydrates

DEFF Research Database (Denmark)

Takeya, Kei; Zhang, Caihong; Kawayama, Iwao

2009-01-01

For the nondestructive inspection of gas hydrates, terahertz (THz) time-domain spectroscopy (TDS) was applied to tetrahydrofuran (THF) hydrate and propane hydrate. The absorption of propane hydrate monotonically increases with frequency, similar to the case of ice, while THF hydrate has...... a characteristic broad absorption peak at 0.5 THz corresponding to the dipole moment of THF molecules. The refractive indices of THF and propane hydrates are 1.725 and 1.775 at 1 THz, respectively, and show a slight but clear difference from the refractive index of ice (1.79). THz-TDS is a potentially useful...... technique for the ondestructive inspection of gas hydrates. # 2009 The Japan Society of Applied Physics...

Finite-element time-domain modeling of electromagnetic data in general dispersive medium using adaptive Padé series

Science.gov (United States)

Cai, Hongzhu; Hu, Xiangyun; Xiong, Bin; Zhdanov, Michael S.

2017-12-01

The induced polarization (IP) method has been widely used in geophysical exploration to identify the chargeable targets such as mineral deposits. The inversion of the IP data requires modeling the IP response of 3D dispersive conductive structures. We have developed an edge-based finite-element time-domain (FETD) modeling method to simulate the electromagnetic (EM) fields in 3D dispersive medium. We solve the vector Helmholtz equation for total electric field using the edge-based finite-element method with an unstructured tetrahedral mesh. We adopt the backward propagation Euler method, which is unconditionally stable, with semi-adaptive time stepping for the time domain discretization. We use the direct solver based on a sparse LU decomposition to solve the system of equations. We consider the Cole-Cole model in order to take into account the frequency-dependent conductivity dispersion. The Cole-Cole conductivity model in frequency domain is expanded using a truncated Padé series with adaptive selection of the center frequency of the series for early and late time. This approach can significantly increase the accuracy of FETD modeling.

On the mixed discretization of the time domain magnetic field integral equation

KAUST Repository

Ulku, Huseyin Arda

2012-09-01

Time domain magnetic field integral equation (MFIE) is discretized using divergence-conforming Rao-Wilton-Glisson (RWG) and curl-conforming Buffa-Christiansen (BC) functions as spatial basis and testing functions, respectively. The resulting mixed discretization scheme, unlike the classical scheme which uses RWG functions as both basis and testing functions, is proper: Testing functions belong to dual space of the basis functions. Numerical results demonstrate that the marching on-in-time (MOT) solution of the mixed discretized MFIE yields more accurate results than that of classically discretized MFIE. © 2012 IEEE.

Mapping possible flowpaths of contaminants through surface and cross-borehole spectral time-domain induced polarization

DEFF Research Database (Denmark)

Bording, Thue Sylvester; Fiandaca, Gianluca; Maurya, Pradip Kumar

Traditional methods for mapping possible flowpaths of contaminants in sedimentary environments by boreholes may often be insufficient. Additional information may be acquired by geophysical methods. In the present study, cross-borehole and surface measurements were performed using time-domain indu......-domain induced polarization (TDIP). After measurements the entire test site was dug out, and the geology was described. A 2D spectral inversion of the combined dataset is presented, which is in great correspondence with the observed geology....

Reflection terahertz time-domain imaging for analysis of an 18th century neoclassical easel painting

DEFF Research Database (Denmark)

Dandolo, Corinna Ludovica Koch; Filtenborg, Troels; Fukunaga, Kaori

2015-01-01

Terahertz time-domain imaging (THz-TDI) has been applied for imaging a hidden portrait and other subsurfacecomposition layers of an 18th century (18C) easel painting by Nicolai Abildgaard, the most important 18CDanish neoclassical painter of historical and mythological subjects. For the first time...

Perfectly matched layer for the time domain finite element method

International Nuclear Information System (INIS)

Rylander, Thomas; Jin Jianming

2004-01-01

A new perfectly matched layer (PML) formulation for the time domain finite element method is described and tested for Maxwell's equations. In particular, we focus on the time integration scheme which is based on Galerkin's method with a temporally piecewise linear expansion of the electric field. The time stepping scheme is constructed by forming a linear combination of exact and trapezoidal integration applied to the temporal weak form, which reduces to the well-known Newmark scheme in the case without PML. Extensive numerical tests on scattering from infinitely long metal cylinders in two dimensions show good accuracy and no signs of instabilities. For a circular cylinder, the proposed scheme indicates the expected second order convergence toward the analytic solution and gives less than 2% root-mean-square error in the bistatic radar cross section (RCS) for resolutions with more than 10 points per wavelength. An ogival cylinder, which has sharp corners supporting field singularities, shows similar accuracy in the monostatic RCS

Discontinuous Galerkin Time-Domain Analysis of Power-Ground Planes Taking Into Account Decoupling Capacitors

KAUST Repository

Li, Ping; Jiang, Li Jun; Bagci, Hakan

2017-01-01

In this paper, a discontinuous Galerkin time-domain (DGTD) method is developed to analyze the power-ground planes taking into account the decoupling capacitors. In the presence of decoupling capacitors, the whole physical system can be split

A wearable microwave antenna array for time-domain breast tumor screening

OpenAIRE

Porter, Emily; Bahrami, Hadi; Santorelli, Adam; Gosselin, Benoit; Rusch, Leslie; Popovic, Milica

2016-01-01

In this work, we present a clinical prototype with a wearable patient interface for microwave breast cancer detection. The long-term aim of the prototype is a breast health monitoring application. The system operates using multistatic time-domain pulsed radar, with 16 flexible antennas embedded into a bra. Unlike the previously reported, table-based prototype with a rigid cup-like holder, the wearable one requires no immersion medium and enables simple localization of breast surface. In compa...

Time-resolved fluorescence monitoring of cholesterol in peripheral blood mononuclear cells

Science.gov (United States)

Martinakova, Z.; Horilova, J.; Lajdova, I.; Marcek Chorvatova, A.

2014-12-01

Precise evaluation of intracellular cholesterol distribution is crucial for improving diagnostics of diseased states associated with cholesterol alteration. Time-resolved fluorescence techniques are tested for non-invasive investigation of cholesterol in living cells. Fluorescent probe NBD attached to cholesterol was employed to evaluate cholesterol distribution in peripheral blood mononuclear cells (PBMC) isolated from the human blood. Fluorescence Lifetime Imaging Microscopy (FLIM) was successfully applied to simultaneously monitor the spatial distribution and the timeresolved characteristics of the NBD-cholesterol fluorescence in PBMC. Gathered data are the first step in the development of a new perspective non-invasive diagnostic method for evaluation of cholesterol modifications in diseases associated with disorders of lipid metabolism.

A full time-domain approach to spatio-temporal dynamics of semiconductor lasers. II. Spatio-temporal dynamics

Science.gov (United States)

Böhringer, Klaus; Hess, Ortwin

The spatio-temporal dynamics of novel semiconductor lasers is discussed on the basis of a space- and momentum-dependent full time-domain approach. To this means the space-, time-, and momentum-dependent Full-Time Domain Maxwell Semiconductor Bloch equations, derived and discussed in our preceding paper I [K. Böhringer, O. Hess, A full time-domain approach to spatio-temporal dynamics of semiconductor lasers. I. Theoretical formulation], are solved by direct numerical integration. Focussing on the device physics of novel semiconductor lasers that profit, in particular, from recent advances in nanoscience and nanotechnology, we discuss the examples of photonic band edge surface emitting lasers (PBE-SEL) and semiconductor disc lasers (SDLs). It is demonstrated that photonic crystal effects can be obtained for finite crystal structures, and leading to a significant improvement in laser performance such as reduced lasing thresholds. In SDLs, a modern device concept designed to increase the power output of surface-emitters in combination with near-diffraction-limited beam quality, we explore the complex interplay between the intracavity optical fields and the quantum well gain material in SDL structures. Our simulations reveal the dynamical balance between carrier generation due to pumping into high energy states, momentum relaxation of carriers, and stimulated recombination from states near the band edge. Our full time-domain approach is shown to also be an excellent framework for the modelling of the interaction of high-intensity femtosecond and picosecond pulses with semiconductor nanostructures. It is demonstrated that group velocity dispersion, dynamical gain saturation and fast self-phase modulation (SPM) are the main causes for the induced changes and asymmetries in the amplified pulse shape and spectrum of an ultrashort high-intensity pulse. We attest that the time constants of the intraband scattering processes are critical to gain recovery. Moreover, we present

1.28 Tbaud Nyquist Signal Transmission using Time-Domain Optical Fourier Transformation based Receiver

DEFF Research Database (Denmark)

Hu, Hao; Kong, Deming; Palushani, Evarist

2013-01-01

We demonstrate transmission of a 1.28-Tbaud Nyquist-OTDM signal over a record distance of 100 km with detection by time-domain optical Fourier transformation followed by FEC decoding, resulting in error-free performance for all tributaries....

Study of two-dimensional transient cavity fields using the finite-difference time-domain technique

Energy Technology Data Exchange (ETDEWEB)

Crisp, J.L.

1988-06-01

This work is intended to be a study into the application of the finite-difference time-domain, or FD-TD technique, to some of the problems faced by designers of equipment used in modern accelerators. In particular it discusses using the FD-TD algorithm to study the field distribution of a simple two-dimensional cavity in both space and time. 18 refs.

Study of two-dimensional transient cavity fields using the finite-difference time-domain technique

International Nuclear Information System (INIS)

Crisp, J.L.

1988-06-01

This work is intended to be a study into the application of the finite-difference time-domain, or FD-TD technique, to some of the problems faced by designers of equipment used in modern accelerators. In particular it discusses using the FD-TD algorithm to study the field distribution of a simple two-dimensional cavity in both space and time. 18 refs

Detection of 320 Gb/s Nyquist OTDM by polarization-insensitive time-domain optical Fourier transformation

DEFF Research Database (Denmark)

Hu, Hao; Kong, Deming; Palushani, Evarist

2013-01-01

320 Gb/s Nyquist-OTDM is generated by rectangular filtering with a bandwidth of 320 GHz and received by polarization-insensitive time-domain optical Fourier transformation (TD-OFT) followed by passive filtering. After the time-to-frequency mapping in the TD-OFT, the Nyquist-OTDM is converted into...

High-speed extended-term time-domain simulation for online cascading analysis of power system

Science.gov (United States)

Fu, Chuan

A high-speed extended-term (HSET) time domain simulator (TDS), intended to become a part of an energy management system (EMS), has been newly developed for use in online extended-term dynamic cascading analysis of power systems. HSET-TDS includes the following attributes for providing situational awareness of high-consequence events: (i) online analysis, including n-1 and n-k events, (ii) ability to simulate both fast and slow dynamics for 1-3 hours in advance, (iii) inclusion of rigorous protection-system modeling, (iv) intelligence for corrective action ID, storage, and fast retrieval, and (v) high-speed execution. Very fast on-line computational capability is the most desired attribute of this simulator. Based on the process of solving algebraic differential equations describing the dynamics of power system, HSET-TDS seeks to develop computational efficiency at each of the following hierarchical levels, (i) hardware, (ii) strategies, (iii) integration methods, (iv) nonlinear solvers, and (v) linear solver libraries. This thesis first describes the Hammer-Hollingsworth 4 (HH4) implicit integration method. Like the trapezoidal rule, HH4 is symmetrically A-Stable but it possesses greater high-order precision (h4 ) than the trapezoidal rule. Such precision enables larger integration steps and therefore improves simulation efficiency for variable step size implementations. This thesis provides the underlying theory on which we advocate use of HH4 over other numerical integration methods for power system time-domain simulation. Second, motivated by the need to perform high speed extended-term time domain simulation (HSET-TDS) for on-line purposes, this thesis presents principles for designing numerical solvers of differential algebraic systems associated with power system time-domain simulation, including DAE construction strategies (Direct Solution Method), integration methods(HH4), nonlinear solvers(Very Dishonest Newton), and linear solvers(SuperLU). We have

Recent advances in marching-on-in-time schemes for solving time domain volume integral equations

KAUST Repository

Sayed, Sadeed Bin; Ulku, Huseyin Arda; Bagci, Hakan

2015-01-01

Transient electromagnetic field interactions on inhomogeneous penetrable scatterers can be analyzed by solving time domain volume integral equations (TDVIEs). TDVIEs are constructed by setting the summation of the incident and scattered field intensities to the total field intensity on the volumetric support of the scatterer. The unknown can be the field intensity or flux/current density. Representing the total field intensity in terms of the unknown using the relevant constitutive relation and the scattered field intensity in terms of the spatiotemporal convolution of the unknown with the Green function yield the final form of the TDVIE. The unknown is expanded in terms of local spatial and temporal basis functions. Inserting this expansion into the TDVIE and testing the resulting equation at discrete times yield a system of equations that is solved by the marching on-in-time (MOT) scheme. At each time step, a smaller system of equations, termed MOT system is solved for the coefficients of the expansion. The right-hand side of this system consists of the tested incident field and discretized spatio-temporal convolution of the unknown samples computed at the previous time steps with the Green function.

Recent advances in marching-on-in-time schemes for solving time domain volume integral equations

KAUST Repository

Sayed, Sadeed Bin

2015-05-16

Transient electromagnetic field interactions on inhomogeneous penetrable scatterers can be analyzed by solving time domain volume integral equations (TDVIEs). TDVIEs are constructed by setting the summation of the incident and scattered field intensities to the total field intensity on the volumetric support of the scatterer. The unknown can be the field intensity or flux/current density. Representing the total field intensity in terms of the unknown using the relevant constitutive relation and the scattered field intensity in terms of the spatiotemporal convolution of the unknown with the Green function yield the final form of the TDVIE. The unknown is expanded in terms of local spatial and temporal basis functions. Inserting this expansion into the TDVIE and testing the resulting equation at discrete times yield a system of equations that is solved by the marching on-in-time (MOT) scheme. At each time step, a smaller system of equations, termed MOT system is solved for the coefficients of the expansion. The right-hand side of this system consists of the tested incident field and discretized spatio-temporal convolution of the unknown samples computed at the previous time steps with the Green function.

Time-domain electromagnetic energy in a frequency-dispersive left-handed medium

International Nuclear Information System (INIS)

Cui Tiejun; Kong Jinau

2004-01-01

From Maxwell's equations and the Poynting theorem, the time-domain electric and magnetic energy densities are generally defined in the frequency-dispersive media based on the conservation of energy. As a consequence, a general definition of electric and magnetic energy is proposed. Comparing with existing formulations of electric and magnetic energy in frequency-dispersive media, the new definition is more reasonable and is valid in any case. Using the new definition and staring from the equation of motion, we have shown rigorously that the total energy density and the individual electric and magnetic energy densities are always positive in a realistic artificial left-handed medium (LHM) [R. A. Shelby, D. R. Smith, and S. Schultz, Science 292, 77 (2001)], which obeys actually the Lorentz medium model, although such a LHM has negative permittivity and negative permeability simultaneously in a certain frequency range. We have also shown that the conservation of energy is not violated in LHM. The earlier conclusions can be easily extended to the Drude medium model and the cold plasma medium model. Through an exact analysis of a one-dimensional transient current source radiating in LHM, numerical results are given to demonstrate that the work done by source, the power flowing outwards a surface, and the electric and magnetic energy stored in a volume are all positive in the time domain

Iterative Refinement Methods for Time-Domain Equalizer Design

Directory of Open Access Journals (Sweden)

Evans Brian L

2006-01-01

Full Text Available Commonly used time domain equalizer (TEQ design methods have been recently unified as an optimization problem involving an objective function in the form of a Rayleigh quotient. The direct generalized eigenvalue solution relies on matrix decompositions. To reduce implementation complexity, we propose an iterative refinement approach in which the TEQ length starts at two taps and increases by one tap at each iteration. Each iteration involves matrix-vector multiplications and vector additions with matrices and two-element vectors. At each iteration, the optimization of the objective function either improves or the approach terminates. The iterative refinement approach provides a range of communication performance versus implementation complexity tradeoffs for any TEQ method that fits the Rayleigh quotient framework. We apply the proposed approach to three such TEQ design methods: maximum shortening signal-to-noise ratio, minimum intersymbol interference, and minimum delay spread.

Analysis of electromagnetic wave interactions on nonlinear scatterers using time domain volume integral equations

KAUST Repository

Ulku, Huseyin Arda; Sayed, Sadeed Bin; Bagci, Hakan

2014-01-01

solvers are the method of choice when it comes simulating these nonlinear effects. Oftentimes, finite difference time domain (FDTD) method is used for this purpose. This is simply due to the fact that explicitness of the FDTD renders the implementation

Time domain spectral phase encoding/DPSK data modulation using single phase modulator for OCDMA application.

Science.gov (United States)

Wang, Xu; Gao, Zhensen; Kataoka, Nobuyuki; Wada, Naoya

2010-05-10

A novel scheme using single phase modulator for simultaneous time domain spectral phase encoding (SPE) signal generation and DPSK data modulation is proposed and experimentally demonstrated. Array- Waveguide-Grating and Variable-Bandwidth-Spectrum-Shaper based devices can be used for decoding the signal directly in spectral domain. The effects of fiber dispersion, light pulse width and timing error on the coding performance have been investigated by simulation and verified in experiment. In the experiment, SPE signal with 8-chip, 20GHz/chip optical code patterns has been generated and modulated with 2.5 Gbps DPSK data using single modulator. Transmission of the 2.5 Gbps data over 34km fiber with BEROCDMA) and secure optical communication applications. (c) 2010 Optical Society of America.

The YARHG domain: an extracellular domain in search of a function.

Directory of Open Access Journals (Sweden)

Penny Coggill

Full Text Available We have identified a new bacterial protein domain that we hypothesise binds to peptidoglycan. This domain is called the YARHG domain after the most highly conserved sequence-segment. The domain is found in the extracellular space and is likely to be composed of four alpha-helices. The domain is found associated with protein kinase domains, suggesting it is associated with signalling in some bacteria. The domain is also found associated with three different families of peptidases. The large number of different domains that are found associated with YARHG suggests that it is a useful functional module that nature has recombined multiple times.

Parallel PWTD-Accelerated Explicit Solution of the Time Domain Electric Field Volume Integral Equation

KAUST Repository

Liu, Yang

2016-03-25

A parallel plane-wave time-domain (PWTD)-accelerated explicit marching-on-in-time (MOT) scheme for solving the time domain electric field volume integral equation (TD-EFVIE) is presented. The proposed scheme leverages pulse functions and Lagrange polynomials to spatially and temporally discretize the electric flux density induced throughout the scatterers, and a finite difference scheme to compute the electric fields from the Hertz electric vector potentials radiated by the flux density. The flux density is explicitly updated during time marching by a predictor-corrector (PC) scheme and the vector potentials are efficiently computed by a scalar PWTD scheme. The memory requirement and computational complexity of the resulting explicit PWTD-PC-EFVIE solver scale as ( log ) s s O N N and ( ) s t O N N , respectively. Here, s N is the number of spatial basis functions and t N is the number of time steps. A scalable parallelization of the proposed MOT scheme on distributed- memory CPU clusters is described. The efficiency, accuracy, and applicability of the resulting (parallelized) PWTD-PC-EFVIE solver are demonstrated via its application to the analysis of transient electromagnetic wave interactions on canonical and real-life scatterers represented with up to 25 million spatial discretization elements.

Parallel PWTD-Accelerated Explicit Solution of the Time Domain Electric Field Volume Integral Equation

KAUST Repository

Liu, Yang; Al-Jarro, Ahmed; Bagci, Hakan; Michielssen, Eric

2016-01-01

A parallel plane-wave time-domain (PWTD)-accelerated explicit marching-on-in-time (MOT) scheme for solving the time domain electric field volume integral equation (TD-EFVIE) is presented. The proposed scheme leverages pulse functions and Lagrange polynomials to spatially and temporally discretize the electric flux density induced throughout the scatterers, and a finite difference scheme to compute the electric fields from the Hertz electric vector potentials radiated by the flux density. The flux density is explicitly updated during time marching by a predictor-corrector (PC) scheme and the vector potentials are efficiently computed by a scalar PWTD scheme. The memory requirement and computational complexity of the resulting explicit PWTD-PC-EFVIE solver scale as ( log ) s s O N N and ( ) s t O N N , respectively. Here, s N is the number of spatial basis functions and t N is the number of time steps. A scalable parallelization of the proposed MOT scheme on distributed- memory CPU clusters is described. The efficiency, accuracy, and applicability of the resulting (parallelized) PWTD-PC-EFVIE solver are demonstrated via its application to the analysis of transient electromagnetic wave interactions on canonical and real-life scatterers represented with up to 25 million spatial discretization elements.

In vitro osteosarcoma biosensing using THz time domain spectroscopy

Science.gov (United States)

Ferguson, Bradley S.; Liu, Haibo; Hay, Shelley; Findlay, David; Zhang, Xi-Cheng; Abbott, Derek

2004-03-01

Terahertz time domain spectroscopy (THz-TDS) has a wide range of applications from semiconductor diagnostics to biosensing. Recent attention has focused on bio-applications and several groups have noted the ability of THz-TDS to differentiate basal cell carcinoma tissue from healthy dermal tissue ex vivo. The contrast mechanism is unclear but has been attributed to increased interstitial water in cancerous tissue. In this work we investigate the THz response of human osteosarcoma cells and normal human bone cells grown in culture to isolate the cells' responses from other effects. A classification algorithms based on a frequency selection by genetic algorithm is used to attempt to differentiate between the cell types based on the THz spectra. Encouraging preliminary results have been obtained.

Algorithm for determining two-periodic steady-states in AC machines directly in time domain

Directory of Open Access Journals (Sweden)

Sobczyk Tadeusz J.

2016-09-01

Full Text Available This paper describes an algorithm for finding steady states in AC machines for the cases of their two-periodic nature. The algorithm enables to specify the steady-state solution identified directly in time domain despite of the fact that two-periodic waveforms are not repeated in any finite time interval. The basis for such an algorithm is a discrete differential operator that specifies the temporary values of the derivative of the two-periodic function in the selected set of points on the basis of the values of that function in the same set of points. It allows to develop algebraic equations defining the steady state solution reached in a chosen point set for the nonlinear differential equations describing the AC machines when electrical and mechanical equations should be solved together. That set of those values allows determining the steady state solution at any time instant up to infinity. The algorithm described in this paper is competitive with respect to the one known in literature an approach based on the harmonic balance method operated in frequency domain.

Electromagnetic Pulse Excitation of Finite-Long Dissipative Conductors over a Conducting Ground Plane in the Time Domain

Energy Technology Data Exchange (ETDEWEB)

Campione, Salvatore [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Warne, Larry K. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Schiek, Richard [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Basilio, Lorena I. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-09-01

This report details the modeling results for the response of a finite-length dissipative conductor interacting with a conducting ground to a hypothetical nuclear device with the same output energy spectrum as the Fat Man device. We use a time-domain method based on transmission line theory that allows accounting for time-varying air conductivities. We implemented such method in a code we call ATLOG - Analytic Transmission Line Over Ground. Results are compared the frequency-domain version of ATLOG previously developed and to the circuit simulator Xyce in some instances. Intentionally Left Blank

Total and domain-specific sitting time among employees in desk-based work settings in Australia.

Science.gov (United States)

Bennie, Jason A; Pedisic, Zeljko; Timperio, Anna; Crawford, David; Dunstan, David; Bauman, Adrian; van Uffelen, Jannique; Salmon, Jo

2015-06-01

To describe the total and domain-specific daily sitting time among a sample of Australian office-based employees. In April 2010, paper-based surveys were provided to desk-based employees (n=801) in Victoria, Australia. Total daily and domain-specific (work, leisure-time and transport-related) sitting time (minutes/day) were assessed by validated questionnaires. Differences in sitting time were examined across socio-demographic (age, sex, occupational status) and lifestyle characteristics (physical activity levels, body mass index [BMI]) using multiple linear regression analyses. The median (95% confidence interval [CI]) of total daily sitting time was 540 (531-557) minutes/day. Insufficiently active adults (median=578 minutes/day, [95%CI: 564-602]), younger adults aged 18-29 years (median=561 minutes/day, [95%CI: 540-577]) reported the highest total daily sitting times. Occupational sitting time accounted for almost 60% of total daily sitting time. In multivariate analyses, total daily sitting time was negatively associated with age (unstandardised regression coefficient [B]=-1.58, pphysical activity (minutes/week) (B=-0.03, pemployees reported that more than half of their total daily sitting time was accrued in the work setting. Given the high contribution of occupational sitting to total daily sitting time among desk-based employees, interventions should focus on the work setting. © 2014 Public Health Association of Australia.

Orthostatic blood pressure control before and after spaceflight, determined by time-domain baroreflex method

NARCIS (Netherlands)

Gisolf, J.; Immink, R. V.; van Lieshout, J. J.; Stok, W. J.; Karemaker, J. M.

2005-01-01

Reduction in plasma volume is a major contributor to orthostatic tachycardia and hypotension after spaceflight. We set out to determine time- and frequency-domain baroreflex (BRS) function during preflight baseline and venous occlusion and postflight orthostatic stress, testing the hypothesis that a

1.28 Tbit/s/channel single-polarization DQPSK transmission over 525 km using ultrafast time-domain optical Fourier transformation

DEFF Research Database (Denmark)

Guan, P.; Mulvad, Hans Christian Hansen; Tomiyama, Y.

2010-01-01

A single-channel 1.28 Tbit/s transmission over 525 km is demonstrated for the first time with a single-polarization DQPSK signal. Ultrafast time-domain optical Fourier transformation is successfully applied to DQPSK signals and results in improved performance and increased system margin.......A single-channel 1.28 Tbit/s transmission over 525 km is demonstrated for the first time with a single-polarization DQPSK signal. Ultrafast time-domain optical Fourier transformation is successfully applied to DQPSK signals and results in improved performance and increased system margin....

Application of Time-Frequency Domain Transform to Three-Dimensional Interpolation of Medical Images.

Science.gov (United States)

Lv, Shengqing; Chen, Yimin; Li, Zeyu; Lu, Jiahui; Gao, Mingke; Lu, Rongrong

2017-11-01

Medical image three-dimensional (3D) interpolation is an important means to improve the image effect in 3D reconstruction. In image processing, the time-frequency domain transform is an efficient method. In this article, several time-frequency domain transform methods are applied and compared in 3D interpolation. And a Sobel edge detection and 3D matching interpolation method based on wavelet transform is proposed. We combine wavelet transform, traditional matching interpolation methods, and Sobel edge detection together in our algorithm. What is more, the characteristics of wavelet transform and Sobel operator are used. They deal with the sub-images of wavelet decomposition separately. Sobel edge detection 3D matching interpolation method is used in low-frequency sub-images under the circumstances of ensuring high frequency undistorted. Through wavelet reconstruction, it can get the target interpolation image. In this article, we make 3D interpolation of the real computed tomography (CT) images. Compared with other interpolation methods, our proposed method is verified to be effective and superior.

An innovative application of time-domain spectroscopy on localized surface plasmon resonance sensing

Science.gov (United States)

Li, Meng-Chi; Chang, Ying-Feng; Wang, Huai-Yi; Lin, Yu-Xen; Kuo, Chien-Cheng; Annie Ho, Ja-An; Lee, Cheng-Chung; Su, Li-Chen

2017-03-01

White-light scanning interferometry (WLSI) is often used to study the surface profiles and properties of thin films because the strength of the technique lies in its ability to provide fast and high resolution measurements. An innovative attempt is made in this paper to apply WLSI as a time-domain spectroscopic system for localized surface plasmon resonance (LSPR) sensing. A WLSI-based spectrometer is constructed with a breadboard of WLSI in combination with a spectral centroid algorithm for noise reduction and performance improvement. Experimentally, the WLSI-based spectrometer exhibits a limit of detection (LOD) of 1.2 × 10-3 refractive index units (RIU), which is better than that obtained with a conventional UV-Vis spectrometer, by resolving the LSPR peak shift. Finally, the bio-applicability of the proposed spectrometer was investigated using the rs242557 tau gene, an Alzheimer’s and Parkinson’s disease biomarker. The LOD was calculated as 15 pM. These results demonstrate that the proposed WLSI-based spectrometer could become a sensitive time-domain spectroscopic biosensing platform.

Time Domain Surface Integral Equation Solvers for Quantum Corrected Electromagnetic Analysis of Plasmonic Nanostructures

KAUST Repository

Uysal, Ismail Enes

2016-10-01

Plasmonic structures are utilized in many applications ranging from bio-medicine to solar energy generation and transfer. Numerical schemes capable of solving equations of classical electrodynamics have been the method of choice for characterizing scattering properties of such structures. However, as dimensions of these plasmonic structures reduce to nanometer scale, quantum mechanical effects start to appear. These effects cannot be accurately modeled by available classical numerical methods. One of these quantum effects is the tunneling, which is observed when two structures are located within a sub-nanometer distance of each other. At these small distances electrons “jump" from one structure to another and introduce a path for electric current to flow. Classical equations of electrodynamics and the schemes used for solving them do not account for this additional current path. This limitation can be lifted by introducing an auxiliary tunnel with material properties obtained using quantum models and applying a classical solver to the structures connected by this auxiliary tunnel. Early work on this topic focused on quantum models that are generated using a simple one-dimensional wave function to find the tunneling probability and assume a simple Drude model for the permittivity of the tunnel. These tunnel models are then used together with a classical frequency domain solver. In this thesis, a time domain surface integral equation solver for quantum corrected analysis of transient plasmonic interactions is proposed. This solver has several advantages: (i) As opposed to frequency domain solvers, it provides results at a broad band of frequencies with a single simulation. (ii) As opposed to differential equation solvers, it only discretizes surfaces (reducing number of unknowns), enforces the radiation condition implicitly (increasing the accuracy), and allows for time step selection independent of spatial discretization (increasing efficiency). The quantum model

Ultrasound breast imaging using frequency domain reverse time migration

Science.gov (United States)

Roy, O.; Zuberi, M. A. H.; Pratt, R. G.; Duric, N.

2016-04-01

Conventional ultrasonography reconstruction techniques, such as B-mode, are based on a simple wave propagation model derived from a high frequency approximation. Therefore, to minimize model mismatch, the central frequency of the input pulse is typically chosen between 3 and 15 megahertz. Despite the increase in theoretical resolution, operating at higher frequencies comes at the cost of lower signal-to-noise ratio. This ultimately degrades the image contrast and overall quality at higher imaging depths. To address this issue, we investigate a reflection imaging technique, known as reverse time migration, which uses a more accurate propagation model for reconstruction. We present preliminary simulation results as well as physical phantom image reconstructions obtained using data acquired with a breast imaging ultrasound tomography prototype. The original reconstructions are filtered to remove low-wavenumber artifacts that arise due to the inclusion of the direct arrivals. We demonstrate the advantage of using an accurate sound speed model in the reverse time migration process. We also explain how the increase in computational complexity can be mitigated using a frequency domain approach and a parallel computing platform.

Study of stratified dielectric slab medium structures using pseudo-spectral time domain (PSTD) algorithm

DEFF Research Database (Denmark)

Tong, M.S.; Lu, Y.; Chen, Y.

2005-01-01

-layer structures are analyzed. Results show that this method matches satisfactorily the Nyquist sampling theorem in terms of spatial discretization. By comparing the given results, it is found that the PSTD method outperforms the finite-difference time-domain (FDTD) method in general, especially in terms...

Dynamic factor analysis in the frequency domain: causal modeling of multivariate psychophysiological time series

NARCIS (Netherlands)

Molenaar, P.C.M.

1987-01-01

Outlines a frequency domain analysis of the dynamic factor model and proposes a solution to the problem of constructing a causal filter of lagged factor loadings. The method is illustrated with applications to simulated and real multivariate time series. The latter applications involve topographic

Time evolution of one-dimensional gapless models from a domain wall initial state: stochastic Loewner evolution continued?

International Nuclear Information System (INIS)

Calabrese, Pasquale; Hagendorf, Christian; Doussal, Pierre Le

2008-01-01

We study the time evolution of quantum one-dimensional gapless systems evolving from initial states with a domain wall. We generalize the path integral imaginary time approach that together with boundary conformal field theory allows us to derive the time and space dependence of general correlation functions. The latter are explicitly obtained for the Ising universality class, and the typical behavior of one- and two-point functions is derived for the general case. Possible connections with the stochastic Loewner evolution are discussed and explicit results for one-point time dependent averages are obtained for generic κ for boundary conditions corresponding to stochastic Loewner evolution. We use this set of results to predict the time evolution of the entanglement entropy and obtain the universal constant shift due to the presence of a domain wall in the initial state

Postural Analysis in Time and Frequency Domains in Patients with Ehlers-Danlos Syndrome

Science.gov (United States)

Galli, Manuela; Rigoldi, Chiara; Celletti, Claudia; Mainardi, Luca; Tenore, Nunzio; Albertini, Giorgio; Camerota, Filippo

2011-01-01

The goal of this work is to analyze postural control in Ehlers-Danlos syndrome (EDS) participants in time and frequency domain. This study considered a pathological group composed by 22 EDS participants performing a postural test consisting in maintaining standing position over a force platform for 30 s in two conditions: open eyes (OE) and closed…

Optical coherence tomography-based decision making in exudative age-related macular degeneration: comparison of time- vs spectral-domain devices.

Science.gov (United States)

Cukras, C; Wang, Y D; Meyerle, C B; Forooghian, F; Chew, E Y; Wong, W T

2010-05-01

To determine whether optical coherence tomography (OCT) device-type influences clinical grading of OCT imaging in the context of exudative age-related macular degeneration (AMD). Ninety-six paired OCT scans from 49 patients with active exudative AMD were obtained on both the time-domain Stratus OCT system and the spectral-domain Cirrus OCT system at the same visit. Three independent graders judged each scan for the presence of intraretinal fluid (IRF) or subretinal fluid (SRF). The degree of grader consensus was evaluated and the ability of the systems to detect the presence of disease activity was analysed. Cirrus OCT generated a higher degree of inter-grader consensus than Stratus OCT with higher intraclass correlation coefficients for all parameters analysed. A pair-wise comparison of Cirrus OCT with Stratus OCT systems revealed that Cirrus-based gradings more frequently reported the presence of SRF and IRF and detected overall neovascular activity at a higher rate (P<0.05) compared with Stratus-based gradings. The choice of time-domain (Stratus) vs spectra-domain (Cirrus) OCT systems has a measurable impact on clinical decision making in exudative AMD. Spectral-domain OCT systems may be able to generate more consensus in clinical interpretation and, in particular cases, detect disease activity not detected by time-domain systems. Clinical trials using OCT-based clinical evaluations of exudative AMD may need to account for these inter-system differences in planning and analysis.

Optical Coherence Tomography-Based Decision Making in Exudative Age-related Macular Degeneration: Comparison of Time- versus Spectral-Domain Devices

Science.gov (United States)

Cukras, Catherine; Wang, Yunqing D.; Meyerle, Catherine B.; Forooghian, Farzin; Chew, Emily Y.; Wong, Wai T.

2010-01-01

Purpose To determine if optical coherence tomography (OCT) device-type influences clinical grading of OCT imaging in the context of exudative age-related macular degeneration (AMD). Methods Ninety-six paired OCT scans from 49 patients with active exudative AMD were obtained on both the time-domain Stratus™ OCT system and the spectral-domain Cirrus™ OCT system at the same visit. Three independent graders judged each scan for the presence of intraretinal fluid (IRF) or subretinal fluid (SRF). The degree of grader consensus was evaluated and the ability of the systems to detect the presence of disease activity was analyzed. Results Cirrus™ OCT generated a higher degree of inter-grader consensus than Stratus OCT with higher intraclass correlation coefficients (ICC) for all parameters analyzed. A pair-wise comparison of Cirrus™ OCT to Stratus™ OCT systems revealed that Cirrus™-based gradings more frequently reported the presence of SRF and IRF and detected overall neovascular activity at a higher rate (p<0.05) compared to Stratus™-based gradings Conclusions The choice of time-domain (Stratus™) versus spectra-domain (Cirrus™) OCT systems has a measurable impact on clinical decision making in exudative AMD. Spectral-domain OCT systems may be able to generate more consensus in clinical interpretation and, in particular cases, detect disease activity not detected by time-domain systems. Clinical trials employing OCT-based clinical evaluations of exudative AMD may need to account for these inter-system differences in planning and analysis. PMID:19696804

Online Identification of a Mechanical System in the Frequency Domain with Short-Time DFT

Directory of Open Access Journals (Sweden)

Niko Nevaranta

2015-07-01

Full Text Available A proper system identification method is of great importance in the process of acquiring an analytical model that adequately represents the characteristics of the monitored system. While the use of different time-domain online identification techniques has been widely recognized as a powerful approach for system diagnostics, the frequency domain identification techniques have primarily been considered for offline commissioning purposes. This paper addresses issues in the online frequency domain identification of a flexible two-mass mechanical system with varying dynamics, and a particular attention is paid to detect the changes in the system dynamics. An online identification method is presented that is based on a recursive Kalman filter configured to perform like a discrete Fourier transform (DFT at a selected set of frequencies. The experimental online identification results are compared with the corresponding values obtained from the offline-identified frequency responses. The results show an acceptable agreement and demonstrate the feasibility of the proposed identification method.

Time-Domain Finite Elements for Virtual Testing of Electromagnetic Compatibility

Directory of Open Access Journals (Sweden)

V. Sedenka

2013-04-01

Full Text Available The paper presents a time-domain finite-element solver developed for simulations related to solving electromagnetic compatibility issues. The software is applied as a module integrated into a computational framework developed within a FP7 European project High Intensity Radiated Field – Synthetic Environment (HIRF SE able to simulate a large class of problems. In the paper, the mathematical formulation is briefly presented, and special emphasis is put on the user point of view on the simulation tool-chain. The functionality is demonstrated on the computation of shielding effectiveness of two composite materials. Results are validated through experimental measurements and agreement is confirmed by automatic feature selective algorithms.

Singular trajectories: space-time domain topology of developing speckle fields

Science.gov (United States)

Vasil'ev, Vasiliy; Soskin, Marat S.

2010-02-01

It is shown the space-time dynamics of optical singularities is fully described by singularities trajectories in space-time domain, or evolution of transverse coordinates(x, y) in some fixed plane z0. The dynamics of generic developing speckle fields was realized experimentally by laser induced scattering in LiNbO3:Fe photorefractive crystal. The space-time trajectories of singularities can be divided topologically on two classes with essentially different scenario and duration. Some of them (direct topological reactions) consist from nucleation of singularities pair at some (x, y, z0, t) point, their movement and annihilation. They possess form of closed loops with relatively short time of existence. Another much more probable class of trajectories are chain topological reactions. Each of them consists from sequence of links, i.e. of singularities nucleation in various points (xi yi, ti) and following annihilation of both singularities in other space-time points with alien singularities of opposite topological indices. Their topology and properties are established. Chain topological reactions can stop on the borders of a developing speckle field or go to infinity. Examples of measured both types of topological reactions for optical vortices (polarization C points) in scalar (elliptically polarized) natural developing speckle fields are presented.

Domain Walls and Matter-Antimatter Domains in the Early Universe

Directory of Open Access Journals (Sweden)

Dolgov A.D.

2017-01-01

Full Text Available We suggest a scenario of spontaneous (or dynamical C and CP violation according to which it is possible to generate domains of matter and antimatter separated by cosmologically large distances. Such C(CP violation existed only in the early universe and later it disappeared with the only trace of generated matter and antimatter domains. So this scenario does not suffer from the problem of domain walls. According to this scenario the width of the domain wall should grow exponentially to prevent annihilation at the domain boundaries. Though there is a classical result obtained by Basu and Vilenkin that the width of the wall tends to the one of the stationary solution (constant physical width. That is why we considered thick domain walls in a de Sitter universe following paper by Basu and Vilenkin. However, we were interested not only in stationary solutions found therein, but also investigated the general case of domain wall evolution with time. When the wall thickness parameter, δ0 , is smaller than H−1/2 where H is the Hubble parameter in de Sitter space-time, then the stationary solutions exist, and initial field configurations tend with time to the stationary ones. However, there are no stationary solutions for δ0>H−1/2 We have calculated numerically the rate of the wall expansion in this case and have found that the width of the wall grows exponentially fast for δ0≫H−1 An explanation for the critical value δ0c=H−1/2 is also proposed.

A Stable Marching on-in-time Scheme for Solving the Time Domain Electric Field Volume Integral Equation on High-contrast Scatterers

KAUST Repository

Sayed, Sadeed Bin

2015-05-05

A time domain electric field volume integral equation (TD-EFVIE) solver is proposed for characterizing transient electromagnetic wave interactions on high-contrast dielectric scatterers. The TD-EFVIE is discretized using the Schaubert- Wilton-Glisson (SWG) and approximate prolate spherical wave (APSW) functions in space and time, respectively. The resulting system of equations can not be solved by a straightforward application of the marching on-in-time (MOT) scheme since the two-sided APSW interpolation functions require the knowledge of unknown “future” field samples during time marching. Causality of the MOT scheme is restored using an extrapolation technique that predicts the future samples from known “past” ones. Unlike the extrapolation techniques developed for MOT schemes that are used in solving time domain surface integral equations, this scheme trains the extrapolation coefficients using samples of exponentials with exponents on the complex frequency plane. This increases the stability of the MOT-TD-EFVIE solver significantly, since the temporal behavior of decaying and oscillating electromagnetic modes induced inside the scatterers is very accurately taken into account by this new extrapolation scheme. Numerical results demonstrate that the proposed MOT solver maintains its stability even when applied to analyzing wave interactions on high-contrast scatterers.

A Stable Marching on-in-time Scheme for Solving the Time Domain Electric Field Volume Integral Equation on High-contrast Scatterers

KAUST Repository

Sayed, Sadeed Bin; Ulku, Huseyin; Bagci, Hakan

2015-01-01

A time domain electric field volume integral equation (TD-EFVIE) solver is proposed for characterizing transient electromagnetic wave interactions on high-contrast dielectric scatterers. The TD-EFVIE is discretized using the Schaubert- Wilton-Glisson (SWG) and approximate prolate spherical wave (APSW) functions in space and time, respectively. The resulting system of equations can not be solved by a straightforward application of the marching on-in-time (MOT) scheme since the two-sided APSW interpolation functions require the knowledge of unknown “future” field samples during time marching. Causality of the MOT scheme is restored using an extrapolation technique that predicts the future samples from known “past” ones. Unlike the extrapolation techniques developed for MOT schemes that are used in solving time domain surface integral equations, this scheme trains the extrapolation coefficients using samples of exponentials with exponents on the complex frequency plane. This increases the stability of the MOT-TD-EFVIE solver significantly, since the temporal behavior of decaying and oscillating electromagnetic modes induced inside the scatterers is very accurately taken into account by this new extrapolation scheme. Numerical results demonstrate that the proposed MOT solver maintains its stability even when applied to analyzing wave interactions on high-contrast scatterers.

A Compact Unconditionally Stable Method for Time-Domain Maxwell's Equations

Directory of Open Access Journals (Sweden)

Zhuo Su

2013-01-01

Full Text Available Higher order unconditionally stable methods are effective ways for simulating field behaviors of electromagnetic problems since they are free of Courant-Friedrich-Levy conditions. The development of accurate schemes with less computational expenditure is desirable. A compact fourth-order split-step unconditionally-stable finite-difference time-domain method (C4OSS-FDTD is proposed in this paper. This method is based on a four-step splitting form in time which is constructed by symmetric operator and uniform splitting. The introduction of spatial compact operator can further improve its performance. Analyses of stability and numerical dispersion are carried out. Compared with noncompact counterpart, the proposed method has reduced computational expenditure while keeping the same level of accuracy. Comparisons with other compact unconditionally-stable methods are provided. Numerical dispersion and anisotropy errors are shown to be lower than those of previous compact unconditionally-stable methods.

A time-domain finite element boundary integral approach for elastic wave scattering

Science.gov (United States)

Shi, F.; Lowe, M. J. S.; Skelton, E. A.; Craster, R. V.

2018-04-01

The response of complex scatterers, such as rough or branched cracks, to incident elastic waves is required in many areas of industrial importance such as those in non-destructive evaluation and related fields; we develop an approach to generate accurate and rapid simulations. To achieve this we develop, in the time domain, an implementation to efficiently couple the finite element (FE) method within a small local region, and the boundary integral (BI) globally. The FE explicit scheme is run in a local box to compute the surface displacement of the scatterer, by giving forcing signals to excitation nodes, which can lie on the scatterer itself. The required input forces on the excitation nodes are obtained with a reformulated FE equation, according to the incident displacement field. The surface displacements computed by the local FE are then projected, through time-domain BI formulae, to calculate the scattering signals with different modes. This new method yields huge improvements in the efficiency of FE simulations for scattering from complex scatterers. We present results using different shapes and boundary conditions, all simulated using this approach in both 2D and 3D, and then compare with full FE models and theoretical solutions to demonstrate the efficiency and accuracy of this numerical approach.

3D airborne EM modeling based on the spectral-element time-domain (SETD) method

Science.gov (United States)

Cao, X.; Yin, C.; Huang, X.; Liu, Y.; Zhang, B., Sr.; Cai, J.; Liu, L.

2017-12-01

In the field of 3D airborne electromagnetic (AEM) modeling, both finite-difference time-domain (FDTD) method and finite-element time-domain (FETD) method have limitations that FDTD method depends too much on the grids and time steps, while FETD requires large number of grids for complex structures. We propose a time-domain spectral-element (SETD) method based on GLL interpolation basis functions for spatial discretization and Backward Euler (BE) technique for time discretization. The spectral-element method is based on a weighted residual technique with polynomials as vector basis functions. It can contribute to an accurate result by increasing the order of polynomials and suppressing spurious solution. BE method is a stable tine discretization technique that has no limitation on time steps and can guarantee a higher accuracy during the iteration process. To minimize the non-zero number of sparse matrix and obtain a diagonal mass matrix, we apply the reduced order integral technique. A direct solver with its speed independent of the condition number is adopted for quickly solving the large-scale sparse linear equations system. To check the accuracy of our SETD algorithm, we compare our results with semi-analytical solutions for a three-layered earth model within the time lapse 10-6-10-2s for different physical meshes and SE orders. The results show that the relative errors for magnetic field B and magnetic induction are both around 3-5%. Further we calculate AEM responses for an AEM system over a 3D earth model in Figure 1. From numerical experiments for both 1D and 3D model, we draw the conclusions that: 1) SETD can deliver an accurate results for both dB/dt and B; 2) increasing SE order improves the modeling accuracy for early to middle time channels when the EM field diffuses fast so the high-order SE can model the detailed variation; 3) at very late time channels, increasing SE order has little improvement on modeling accuracy, but the time interval plays

On spurious resonant modes in the MOT solution of time domain EFIE

KAUST Repository

Shi, Yifei

2013-07-01

Theoretically, internal resonant modes should not be induced in the marching-on-in-time (MOT) solution of the time domain electric field integral equation since zero initial conditions are enforced at the beginning of time marching and the internal resonant modes do not satisfy these initial conditions. However, these spurious modes are always observed in the MOT solution. It has been conjectured in the past that numerical errors might establish the necessary initial conditions and allow the incident field to induce the internal resonant modes. Systematic numerical experiments carried out in this work prove this conjecture by demonstrating that the internal resonant modes\\' amplitudes are indeed dictated by the numerical errors and the spectrum of the incident field. © 2013 IEEE.

Toward practical terahertz time-domain spectroscopy

Science.gov (United States)

Brigada, David J.

Terahertz time-domain spectroscopy is a promising technology for the identification of explosive and pharmaceutical substances in adverse conditions. It interacts strongly with intermolecular vibrational and rotational modes. Terahertz also passes through many common dielectric covering materials, allowing for the identification of substances in envelopes, wrapped in opaque plastic, or otherwise hidden. However, there are several challenges preventing the adoption of terahertz spectroscopy outside the laboratory. This dissertation examines the problems preventing widespread adoption of terahertz technology and attempts to resolve them. In order to use terahertz spectroscopy to identify substances, a spectrum measured of the target sample must be compared to the spectra of various known standard samples. This dissertation examines various methods that can be employed throughout the entire process of acquiring and transforming terahertz waveforms to improve the accuracy of these comparisons. The concepts developed in this dissertation directly apply to terahertz spectroscopy, but also carry implications for other spectroscopy methods, from Raman to mass spectrometry. For example, these techniques could help to lower the rate of false positives at airport security checkpoints. This dissertation also examines the implementation of several of these methods as a way to realize a fully self-contained, handheld, battery-operated terahertz spectrometer. This device also employs techniques to allow minimally-trained operators use terahertz to detect different substances of interest. It functions as a proof-of-concept of the true benefits of the improvements that have been developed in this dissertation.

Parallel, explicit, and PWTD-enhanced time domain volume integral equation solver

KAUST Repository

Liu, Yang

2013-07-01

Time domain volume integral equations (TDVIEs) are useful for analyzing transient scattering from inhomogeneous dielectric objects in applications as varied as photonics, optoelectronics, and bioelectromagnetics. TDVIEs typically are solved by implicit marching-on-in-time (MOT) schemes [N. T. Gres et al., Radio Sci., 36, 379-386, 2001], requiring the solution of a system of equations at each and every time step. To reduce the computational cost associated with such schemes, [A. Al-Jarro et al., IEEE Trans. Antennas Propagat., 60, 5203-5215, 2012] introduced an explicit MOT-TDVIE method that uses a predictor-corrector technique to stably update field values throughout the scatterer. By leveraging memory-efficient nodal spatial discretization and scalable parallelization schemes [A. Al-Jarro et al., in 28th Int. Rev. Progress Appl. Computat. Electromagn., 2012], this solver has been successfully applied to the analysis of scattering phenomena involving 0.5 million spatial unknowns. © 2013 IEEE.

Time-domain full waveform inversion using the gradient preconditioning based on transmitted waves energy

KAUST Repository

Zhang, Xiao-bo

2017-06-01

The gradient preconditioning approach based on seismic wave energy can effectively avoid the huge storage consumption in the gradient preconditioning algorithms based on Hessian matrices in time-domain full waveform inversion (FWI), but the accuracy is affected by the energy of reflected waves when strong reflectors are present in velocity model. To address this problem, we propose a gradient preconditioning method, which scales the gradient based on the energy of the “approximated transmitted wavefield” simulated by the nonreflecting acoustic wave equation. The method does not require computing or storing the Hessian matrix or its inverse. Furthermore, it can effectively eliminate the effects caused by geometric diffusion and non-uniformity illumination on gradient. The results of model experiments confirm that the time-domain FWI using the gradient preconditioning based on transmitted waves energy can achieve higher inversion precision for high-velocity body and the deep strata below when compared with using the gradient preconditioning based on seismic waves energy.

Fast and non-destructive pore structure analysis using terahertz time-domain spectroscopy.

OpenAIRE

Markl, Daniel; Bawuah, Prince; Ridgway, Cathy; van den Ban, Sander; Goodwin, Daniel J; Ketolainen, Jarkko; Gane, Patrick; Peiponen, Kai-Erik; Zeitler, Jochen Axel

2018-01-01

Pharmaceutical tablets are typically manufactured by the uni-axial compaction of powder that is confined radially by a rigid die. The directional nature of the compaction process yields not only anisotropic mechanical properties (e.g. tensile strength) but also directional properties of the pore structure in the porous compact. This study derives a new quantitative parameter, $S_a$, to describe the anisotropy in pore structure of pharmaceutical tablets based on terahertz time-domain spectrosc...

Time-resolved experiments in the frequency domain using synchrotron radiation (invited)

Science.gov (United States)

De Stasio, Gelsomina; Giusti, A. M.; Parasassi, T.; Ravagnan, G.; Sapora, O.

1992-01-01

PLASTIQUE is the only synchrotron radiation beam line in the world that performs time-resolved fluorescence experiments in frequency domain. These experiments are extremely valuable sources of information on the structure and the dynamics of molecules. This technique measures fluorescence lifetimes with picosecond resolution in the near UV spectral range. Such accurate measurements are rendered possible by taking phase and modulation data, and by the advantages of the cross-correlation technique. A successful experiment demonstrated the radiation damage induced by low doses of radiation on rabbit blood cell membranes.

Discrete-Time Domain Modelling of Voltage Source Inverters in Standalone Applications

DEFF Research Database (Denmark)

Federico, de Bosio; de Sousa Ribeiro, Luiz Antonio; Freijedo Fernandez, Francisco Daniel

2017-01-01

modelling of the LC plant with consideration of delay and sample-and-hold effects on the state feedback cross-coupling decoupling is derived. From this plant formulation, current controllers with wide bandwidth and good relative stability properties are developed. Two controllers based on lead compensation......The decoupling of the capacitor voltage and inductor current has been shown to improve significantly the dynamic performance of voltage source inverters in standalone applications. However, the computation and PWM delays still limit the achievable bandwidth. In this paper a discrete-time domain...

Discrimination of Temperature and Strain in Brillouin Optical Time Domain Analysis Using a Multicore Optical Fiber.

Science.gov (United States)

Zaghloul, Mohamed A S; Wang, Mohan; Milione, Giovanni; Li, Ming-Jun; Li, Shenping; Huang, Yue-Kai; Wang, Ting; Chen, Kevin P

2018-04-12

Brillouin optical time domain analysis is the sensing of temperature and strain changes along an optical fiber by measuring the frequency shift changes of Brillouin backscattering. Because frequency shift changes are a linear combination of temperature and strain changes, their discrimination is a challenge. Here, a multicore optical fiber that has two cores is fabricated. The differences between the cores' temperature and strain coefficients are such that temperature (strain) changes can be discriminated with error amplification factors of 4.57 °C/MHz (69.11 μ ϵ /MHz), which is 2.63 (3.67) times lower than previously demonstrated. As proof of principle, using the multicore optical fiber and a commercial Brillouin optical time domain analyzer, the temperature (strain) changes of a thermally expanding metal cylinder are discriminated with an error of 0.24% (3.7%).

Discrimination of Temperature and Strain in Brillouin Optical Time Domain Analysis Using a Multicore Optical Fiber

Directory of Open Access Journals (Sweden)

Mohamed A. S. Zaghloul

2018-04-01

Full Text Available Brillouin optical time domain analysis is the sensing of temperature and strain changes along an optical fiber by measuring the frequency shift changes of Brillouin backscattering. Because frequency shift changes are a linear combination of temperature and strain changes, their discrimination is a challenge. Here, a multicore optical fiber that has two cores is fabricated. The differences between the cores’ temperature and strain coefficients are such that temperature (strain changes can be discriminated with error amplification factors of 4.57 °C/MHz (69.11 μ ϵ /MHz, which is 2.63 (3.67 times lower than previously demonstrated. As proof of principle, using the multicore optical fiber and a commercial Brillouin optical time domain analyzer, the temperature (strain changes of a thermally expanding metal cylinder are discriminated with an error of 0.24% (3.7%.

A time-domain digitally controlled oscillator composed of a free running ring oscillator and flying-adder

International Nuclear Information System (INIS)

Liu Wei; Zhang Shengdong; Wang Yangyuan; Li Wei; Ren Peng; Lin Qinglong

2009-01-01

A time-domain digitally controlled oscillator (DCO) is proposed. The DCO is composed of a free-running ring oscillator (FRO) and a two lap-selectors integrated flying-adder (FA). With a coiled cell array which allows uniform loading capacitances of the delay cells, the FRO produces 32 outputs with consistent tap spacing for the FA as reference clocks. The FA uses the outputs from the FRO to generate the output of the DCO according to the control number, resulting in a linear dependence of the output period, instead of the frequency on the digital controlling word input. Thus the proposed DCO ensures a good conversion linearity in a time-domain, and is suitable for time-domain all-digital phase locked loop applications. The DCO was implemented in a standard 0.13 μm digital logic CMOS process. The measurement results show that the DCO has a linear and monotonic tuning curve with gain variation of less than 10%, and a very low root mean square period jitter of 9.3 ps in the output clocks. The DCO works well at supply voltages ranging from 0.6 to 1.2 V, and consumes 4 mW of power with 500 MHz frequency output at 1.2 V supply voltage.

Explicit solution of the time domain magnetic field integral equation using a predictor-corrector scheme

KAUST Repository

Ulku, Huseyin Arda; Bagci, Hakan; Michielssen, Eric

2012-01-01

An explicit yet stable marching-on-in-time (MOT) scheme for solving the time domain magnetic field integral equation (TD-MFIE) is presented. The stability of the explicit scheme is achieved via (i) accurate evaluation of the MOT matrix elements using closed form expressions and (ii) a PE(CE) m type linear multistep method for time marching. Numerical results demonstrate the accuracy and stability of the proposed explicit MOT-TD-MFIE solver. © 2012 IEEE.

Explicit solution of the time domain magnetic field integral equation using a predictor-corrector scheme

KAUST Repository

Ulku, Huseyin Arda

2012-09-01

An explicit yet stable marching-on-in-time (MOT) scheme for solving the time domain magnetic field integral equation (TD-MFIE) is presented. The stability of the explicit scheme is achieved via (i) accurate evaluation of the MOT matrix elements using closed form expressions and (ii) a PE(CE) m type linear multistep method for time marching. Numerical results demonstrate the accuracy and stability of the proposed explicit MOT-TD-MFIE solver. © 2012 IEEE.

Coevolved Mutations Reveal Distinct Architectures for Two Core Proteins in the Bacterial Flagellar Motor.

Directory of Open Access Journals (Sweden)

Alessandro Pandini

Full Text Available Switching of bacterial flagellar rotation is caused by large domain movements of the FliG protein triggered by binding of the signal protein CheY to FliM. FliG and FliM form adjacent multi-subunit arrays within the basal body C-ring. The movements alter the interaction of the FliG C-terminal (FliGC "torque" helix with the stator complexes. Atomic models based on the Salmonella entrovar C-ring electron microscopy reconstruction have implications for switching, but lack consensus on the relative locations of the FliG armadillo (ARM domains (amino-terminal (FliGN, middle (FliGM and FliGC as well as changes during chemotaxis. The generality of the Salmonella model is challenged by the variation in motor morphology and response between species. We studied coevolved residue mutations to determine the unifying elements of switch architecture. Residue interactions, measured by their coevolution, were formalized as a network, guided by structural data. Our measurements reveal a common design with dedicated switch and motor modules. The FliM middle domain (FliMM has extensive connectivity most simply explained by conserved intra and inter-subunit contacts. In contrast, FliG has patchy, complex architecture. Conserved structural motifs form interacting nodes in the coevolution network that wire FliMM to the FliGC C-terminal, four-helix motor module (C3-6. FliG C3-6 coevolution is organized around the torque helix, differently from other ARM domains. The nodes form separated, surface-proximal patches that are targeted by deleterious mutations as in other allosteric systems. The dominant node is formed by the EHPQ motif at the FliMMFliGM contact interface and adjacent helix residues at a central location within FliGM. The node interacts with nodes in the N-terminal FliGc α-helix triad (ARM-C and FliGN. ARM-C, separated from C3-6 by the MFVF motif, has poor intra-network connectivity consistent with its variable orientation revealed by structural data. ARM

Application of Time Domain Reflectometers in Urban Settings ...

Science.gov (United States)

Time domain reflectometers (TDRs) are sensors that measure the volumetric water content of soils and porous media. The sensors consist of stainless steel rods connected to a circuit board in an epoxy housing. An electromagnetic pulse is propagated along the rods. The time, or period, required for the signal to travel down the rods and back varies with the volumetric water content of the surrounding media and temperature. A calibration curve is needed for the specific media. TDRs were developed mostly for agricultural applications; however, the technology has also been applied to forestry and ecological research. This study demonstrates the use of TDRs for quantifying drainage properties in low impact development (LID) stormwater controls, specifically permeable pavement and rain garden systems. TDRs were successfully used to monitor the responses of urban fill, engineered bioretention media, and the aggregate storage layer under permeable pavement to multiple rain events of varying depth, intensity, and duration. The hydrologic performance of permeable pavement and rain garden systems has previously been quantified for underdrain systems, but there have been few studies of systems that drain to the underlying soils. We know of no published studies outlining the use of TDR technology to document drainage properties in media other than soil. In this study TDRs were installed at multiple locations and depths in underlying urban fill soils, engineered bior

Mars SubsurfAce Sounding by Time-Domain Electromagnetic MeasuRements

Science.gov (United States)

Tacconi, G.; Minna, L.; Pagnan, S.; Tacconi, M.

1999-09-01

MASTER (Mars subsurfAce Sounding by Time-domain Electromagnetic measuRements) is an experimental project proposed to fly aboard the Italian Drill (DEEDRI) payload for the Mars Surveyor Program 2003. MASTER will offer the scientific community the first opportunity to scan Mars subsurface structure by means of the technique employing time-domain electromagnetic measurements TDEM. Up today proposed experiments for scanning the Martian subsurface have focused on exploring the crust of the planet Mars up to few meters, while MASTER will explore electrical structures and related soil characteristics and processes at depths up to hundreds meters at least. TDEM represents an active remote sensing system and will be used likely a ULF/ELF/VLF ``radar." If a certain volumetric zone has different electrical conductivity, the current in the sample will vary generating a secondary scattered electromagnetic field containing the information about the explored volume. The volumetric mean value of the conductivity will be estimated according to the implicit near field e.m. propagation conditions, considering the skin depth (d) and the apparent resistivity (ra) as the most representative and critical parameters. As any active remotely sensed measurements the TDEM system behaves like a ``bistatic" communication channel and is mandatory to investigate the characteristics of the background noise at the receiver site. The MASTER system, can operate also as a passive listening device of the possible electromagnetic background noise on the Mars surface at ULF/ELF/VLF bands. Present paper will describe in details the application of the TDEM method as well as the approaches to the detection and estimation of the e.m. BGN on Mars surface, in terms of man made, natural BGN and intrinsic noise of the sensors and electronic systems. The electromagnetic background noise detection/estimation represents by itself a no cost experiment and the first experiment of this type on Mars.

New developments in THz-time domain spectroscopy involving ML-VECSELs

Science.gov (United States)

Apostolopoulos, Vasilis; Tropper, Anne C.; Keenlyside, Benjamin; Chen-Sverre, Theo; Woods, Jonathan R. C.

2018-02-01

The THz time domain spectrometer (THz-TDS) has revolutionized the adoption of THz science in fields such as medicine, material characterization, pharmaceutical research and biology among others. Traditionally a THz-TDS was based on a titanium sapphire laser, while most of the commercially sold spectrometers today adopt fiber lasers. Vertical External Cavity Surface emitting lasers or VECSELs have potential to be the future laser of choice for the implementation of THz spectrometers, as they are small, low-cost, low noise and high repetition rate. Here I will outline the progress in our laboratory and the general community concerning VECSEL-THz technology and I will account the problems that have to be solved for the VECSEL-THz technology to succeed.

Durations and domains of daily aerobic activity: evidence from the 2010 Canadian time-use survey.

Science.gov (United States)

Millward, Hugh; Spinney J, E L; Scott, Darren

2014-07-01

This study employs national time-diary data to evaluate how much aerobic activity Canadians engage in on a daily basis, how that activity is apportioned by activity domain, and how subgroups within the population vary in their aerobic attainment. The study employs time-use data from the 2010 General Social Survey of Canada, for 15,390 respondents aged 15 and older. To estimate effort levels, the authors harmonized survey codes with those in the Compendium of Physical Activities. Aerobic activity was defined as moderate or vigorous effort at 3.5 Metabolic Equivalent of Task (MET) or higher. Among the 4 activity domains, aerobic participation is highest in leisure activities, followed by chores, paid work, and active transportation (AT). Only a minority (42%) of respondents recorded at least 20 mins/day of aerobic activity. Aerobic totals were particularly low for women and those in poor or fair health, and low for students, 15- to 24-year-olds, and those residing in Quebec, Ontario, and larger cities. The majority of Canadian adults are failing to meet recommended aerobic activity levels. However, there is considerable opportunity to increase aerobic participation for some groups, particularly women and young adults, especially in the leisure and AT domains.

analysis of large electromagnetic pulse simulators using the electric field integral equation method in time domain

International Nuclear Information System (INIS)

Jamali, J.; Aghajafari, R.; Moini, R.; Sadeghi, H.

2002-01-01

A time-domain approach is presented to calculate electromagnetic fields inside a large Electromagnetic Pulse (EMP) simulator. This type of EMP simulator is used for studying the effect of electromagnetic pulses on electrical apparatus in various structures such as vehicles, a reoplanes, etc. The simulator consists of three planar transmission lines. To solve the problem, we first model the metallic structure of the simulator as a grid of conducting wires. The numerical solution of the governing electric field integral equation is then obtained using the method of moments in time domain. To demonstrate the accuracy of the model, we consider a typical EMP simulator. The comparison of our results with those obtained experimentally in the literature validates the model introduced in this paper

Time-domain Hydroelasticity Theory of Ships Responding to Waves

DEFF Research Database (Denmark)

Xia, Jinzhu; Wang, Zhaohui

1997-01-01

free surface flow. The general interface boundary condition is used in the mathematical formulation of the fluid motion around the flexible structure. The general time-domain theory is simplified to a slender-body theory for the analysis of wave-induced global responses of monohull ships. The structure...... is represented by a non-uniform beam, while the generalized hydrodynamic coefficients can be obtained from two-dimensional potential flow theory. The linear slender body theory is generalized to treat the non-linear loading effects of rigid motion and structural response of ships travelling in rough seas....... The non-linear hydrostatic restoring force and hydrodynamic momentum action are considered. A numerical solution is presented for the slender body theory. Numerical examples are given for two ship cases with different geometry features, a warship hull and the S175 containership with two different bow...

Numerical integration of the Teukolsky equation in the time domain

International Nuclear Information System (INIS)

Pazos-Avalos, Enrique; Lousto, Carlos O.

2005-01-01

We present a fourth-order convergent (2+1)-dimensional, numerical formalism to solve the Teukolsky equation in the time domain. Our approach is first to rewrite the Teukolsky equation as a system of first-order differential equations. In this way we get a system that has the form of an advection equation. This is then used in combination with a series expansion of the solution in powers of time. To obtain a fourth-order scheme we kept terms up to fourth derivative in time and use the advectionlike system of differential equations to substitute the temporal derivatives by spatial derivatives. This scheme is applied to evolve gravitational perturbations in the Schwarzschild and Kerr backgrounds. Our numerical method proved to be stable and fourth-order convergent in r* and θ directions. The correct power-law tail, ∼1/t 2l+3 , for general initial data, and ∼1/t 2l+4 , for time-symmetric data, was found in our runs. We noted that it is crucial to resolve accurately the angular dependence of the mode at late times in order to obtain these values of the exponents in the power-law decay. In other cases, when the decay was too fast and round-off error was reached before a tail was developed, then the quasinormal modes frequencies provided a test to determine the validity of our code

Time domain simulation of piezoelectric excitation of guided waves in rails using waveguide finite elements

CSIR Research Space (South Africa)

Loveday, PW

2007-03-01

Full Text Available Piezoelectric transducers are commonly used to excite waves in elastic waveguides such as pipes, rock bolts and rails. While it is possible to simulate the operation of these transducers attached to the waveguide, in the time domain, using...

Rating knowledge sharing in cross-domain collaborative filtering.

Science.gov (United States)

Li, Bin; Zhu, Xingquan; Li, Ruijiang; Zhang, Chengqi

2015-05-01

Cross-domain collaborative filtering (CF) aims to share common rating knowledge across multiple related CF domains to boost the CF performance. In this paper, we view CF domains as a 2-D site-time coordinate system, on which multiple related domains, such as similar recommender sites or successive time-slices, can share group-level rating patterns. We propose a unified framework for cross-domain CF over the site-time coordinate system by sharing group-level rating patterns and imposing user/item dependence across domains. A generative model, say ratings over site-time (ROST), which can generate and predict ratings for multiple related CF domains, is developed as the basic model for the framework. We further introduce cross-domain user/item dependence into ROST and extend it to two real-world cross-domain CF scenarios: 1) ROST (sites) for alleviating rating sparsity in the target domain, where multiple similar sites are viewed as related CF domains and some items in the target domain depend on their correspondences in the related ones; and 2) ROST (time) for modeling user-interest drift over time, where a series of time-slices are viewed as related CF domains and a user at current time-slice depends on herself in the previous time-slice. All these ROST models are instances of the proposed unified framework. The experimental results show that ROST (sites) can effectively alleviate the sparsity problem to improve rating prediction performance and ROST (time) can clearly track and visualize user-interest drift over time.

Direct Time Domain Numerical Analysis of Transient Behavior of a VLFS during Unsteady External Loads in Wave Condition

Directory of Open Access Journals (Sweden)

Yong Cheng

2014-01-01

Full Text Available The transient response of the VLFS subjected to arbitrary external load is systematically investigated by a direct time domain modal expansion method, in which the BEM solutions based on time domain Kelvin sources are used for hydrodynamic forces. In the analysis, the time domain free-surface Green functions with sufficient accuracy are rapidly evaluated in finite water depth by the interpolation-tabulation method, and the boundary integral equation with a quarter VLFS model is established taking advantage of symmetry of flow field and structure. The validity of the present method is verified by comparing with the time histories of vertical displacements of the VLFS during a mass drop and airplane landing and takeoff in still water conditions, respectively. Then the developed numerical scheme is used in wave conditions to study the combined action taking into account the mass drop/airplane landing/takeoff loads as well as incident wave action. It is found that the elevation of structural waves due to mass drop load can be significantly changed near the impact region, while the vertical motion of runway in wave conditions is dominant as compared with that only generated by airplane.

Investigation on broadband propagation characteristic of terahertz electromagnetic wave in anisotropic magnetized plasma in frequency and time domain

Energy Technology Data Exchange (ETDEWEB)

Tian, Yuan; Han, Yiping, E-mail: yphan@xidian.edu.cn [School of Physics and Optoelectronic Engineering, Xidian University, Xi' an 710071 (China); Ai, Xia [National Key Laboratory of Science and Technology on Test physics and Numerical Mathematical, Beijing 100076 (China); Liu, Xiuxiang [Science and Technology on Space Physics Laboratory, Beijing 100076 (China)

2014-12-15

In this paper, we investigate the propagation of terahertz (THz) electromagnetic wave in an anisotropic magnetized plasma by JE convolution-finite difference time domain method. The anisotropic characteristic of the plasma, which leads to right-hand circularly polarized (RCP) and right-hand circularly polarized (LCP) waves, has been taken into account. The interaction between electromagnetic waves and magnetized plasma is illustrated by reflection and transmission coefficients for both RCP and LCP THz waves. The effects of both the magnetized plasma thickness and the external magnetized field are analyzed and numerical results demonstrate that the two factors could influence the THz wave greatly. It is worthy to note that besides the reflection and transmission coefficients in the frequency domain, the waveform of the electric field in the time domain varying with thicknesses and external magnetic fields for different polarized direction has been studied.

High-resolution imaging of basal cell carcinoma: a comparison between multiphoton microscopy with fluorescence lifetime imaging and reflectance confocal microscopy.

Science.gov (United States)

Manfredini, Marco; Arginelli, Federica; Dunsby, Christopher; French, Paul; Talbot, Clifford; König, Karsten; Pellacani, Giovanni; Ponti, Giovanni; Seidenari, Stefania

2013-02-01

The aim of this study was to compare morphological aspects of basal cell carcinoma (BCC) as assessed by two different imaging methods: in vivo reflectance confocal microscopy (RCM) and multiphoton tomography with fluorescence lifetime imaging implementation (MPT-FLIM). The study comprised 16 BCCs for which a complete set of RCM and MPT-FLIM images were available. The presence of seven MPT-FLIM descriptors was evaluated. The presence of seven RCM equivalent parameters was scored in accordance to their extension. Chi-squared test with Fisher's exact test and Spearman's rank correlation coefficient were determined between MPT-FLIM scores and adjusted-RCM scores. MPT-FLIM and RCM descriptors of BCC were coupled to match the descriptors that define the same pathological structures. The comparison included: Streaming and Aligned elongated cells, Streaming with multiple directions and Double alignment, Palisading (RCM) and Palisading (MPT-FLIM), Typical tumor islands, and Cell islands surrounded by fibers, Dark silhouettes and Phantom islands, Plump bright cells and Melanophages, Vessels (RCM), and Vessels (MPT-FLIM). The parameters that were significantly correlated were Melanophages/Plump Bright Cells, Aligned elongated cells/Streaming, Double alignment/Streaming with multiple directions, and Palisading (MPT-FLIM)/Palisading (RCM). According to our data, both methods are suitable to image BCC's features. The concordance between MPT-FLIM and RCM is high, with some limitations due to the technical differences between the two devices. The hardest difficulty when comparing the images generated by the two imaging modalities is represented by their different field of view. © 2012 John Wiley & Sons A/S.

Numerical modeling of wind turbine aerodynamic noise in the time domain.

Science.gov (United States)

Lee, Seunghoon; Lee, Seungmin; Lee, Soogab

2013-02-01

Aerodynamic noise from a wind turbine is numerically modeled in the time domain. An analytic trailing edge noise model is used to determine the unsteady pressure on the blade surface. The far-field noise due to the unsteady pressure is calculated using the acoustic analogy theory. By using a strip theory approach, the two-dimensional noise model is applied to rotating wind turbine blades. The numerical results indicate that, although the operating and atmospheric conditions are identical, the acoustical characteristics of wind turbine noise can be quite different with respect to the distance and direction from the wind turbine.

Using the time domain reflectometer to check for a locate a fault

International Nuclear Information System (INIS)

Ramphal, M.; Sadok, E.

1995-01-01

The Time Domain Reflectometer (TDR) is one of the most useful tools for finding cable faults (opens, shorts, bad cable splices). The TDR is connected to the end of the line and shows the distance to the fault. It uses a low voltage signal that will not damage the line or interfere with nearby lines. The TDR sends a pulse or energy down the cable under test; when the pulse encounters the end of the cable or any cable fault, a portion of the pulse energy is reflected. The elapsed time of the reflected pulse is and indication of the distance to the fault. The shape of the reflected pulse uniquely identifies the type of cable fault. (author)

Determination of the optical properties of melanin-pigmented human skin equivalents using terahertz time-domain spectroscopy

Science.gov (United States)

Lipscomb, Dawn; Echchgadda, Ibtissam; Peralta, Xomalin G.; Wilmink, Gerald J.

2013-02-01

Terahertz time-domain spectroscopy (THz-TDS) methods have been utilized in previous studies in order to characterize the optical properties of skin and its primary constituents (i.e., water, collagen, and keratin). However, similar experiments have not yet been performed to investigate whether melanocytes and the melanin pigment that they synthesize contribute to skin's optical properties. In this study, we used THz-TDS methods operating in transmission geometry to measure the optical properties of in vitro human skin equivalents with or without normal human melanocytes. Skin equivalents were cultured for three weeks to promote gradual melanogenesis, and THz time domain data were collected at various time intervals. Frequency-domain analysis techniques were performed to determine the index of refraction (n) and absorption coefficient (μa) for each skin sample over the frequency range of 0.1-2.0 THz. We found that for all samples as frequency increased, n decreased exponentially and the μa increased linearly. Additionally, we observed that skin samples with higher levels of melanin exhibited greater n and μa values than the non-pigmented samples. Our results indicate that melanocytes and the degree of melanin pigmentation contribute in an appreciable manner to the skin's optical properties. Future studies will be performed to examine whether these contributions are observed in human skin in vivo.

From blackbirds to black holes: Investigating capture-recapture methods for time domain astronomy

Science.gov (United States)

Laycock, Silas G. T.

2017-07-01

In time domain astronomy, recurrent transients present a special problem: how to infer total populations from limited observations. Monitoring observations may give a biassed view of the underlying population due to limitations on observing time, visibility and instrumental sensitivity. A similar problem exists in the life sciences, where animal populations (such as migratory birds) or disease prevalence, must be estimated from sparse and incomplete data. The class of methods termed Capture-Recapture is used to reconstruct population estimates from time-series records of encounters with the study population. This paper investigates the performance of Capture-Recapture methods in astronomy via a series of numerical simulations. The Blackbirds code simulates monitoring of populations of transients, in this case accreting binary stars (neutron star or black hole accreting from a stellar companion) under a range of observing strategies. We first generate realistic light-curves for populations of binaries with contrasting orbital period distributions. These models are then randomly sampled at observing cadences typical of existing and planned monitoring surveys. The classical capture-recapture methods, Lincoln-Peterson, Schnabel estimators, related techniques, and newer methods implemented in the Rcapture package are compared. A general exponential model based on the radioactive decay law is introduced which is demonstrated to recover (at 95% confidence) the underlying population abundance and duty cycle, in a fraction of the observing visits (10-50%) required to discover all the sources in the simulation. Capture-Recapture is a promising addition to the toolbox of time domain astronomy, and methods implemented in R by the biostats community can be readily called from within python.

Gating in time domain as a tool for improving the signal-to-noise ratio of beam transfer function measurements

CERN Document Server

Oeftiger, U; Caspers, Fritz

1992-01-01

For the measurement of Beam Transfer Functions the signal-to-noise ratio is of great importance. In order to get a reasonable quality of the measured data one may apply averaging and smoothing. In the following another technique called time gating to improve the quality of the measurement will be described. By this technique the measurement data are Fourier transformed and then modified in time domain. Tune gating suppresses signal contributions that are correlated to a time interval when no interesting information is expected. Afterivards an inverse Fourier transform leads to data in frequency domain with an improved signal to noise ratio.

Rapid screening of fatty acid alkyl esters in olive oils by time domain reflectometry.

Science.gov (United States)

Berardinelli, Annachiara; Ragni, Luigi; Bendini, Alessandra; Valli, Enrico; Conte, Lanfranco; Guarnieri, Adriano; Toschi, Tullia Gallina

2013-11-20

The main aim of the present research is to assess the possibility of quickly screening fatty acid alkyl esters (FAAE) in olive oils using time domain reflectometry (TDR) and partial least-squares (PLS) multivariate statistical analysis. Eighteen virgin olive oil samples with fatty acid alkyl ester contents and fatty acid ethyl ester/methyl ester ratios (FAEE/FAME) ranging from 3 to 100 mg kg(-1) and from 0.3 to 2.6, respectively, were submitted to tests with time domain resolution of 1 ps. The results obtained in test set validation demonstrated that this new and fast analytical approach is able to predict FAME, FAEE, and FAME + FAEE contents with R(2) values of 0.905, 0.923, and 0.927, respectively. Further measurements on mixtures between olive oil and FAAE standards confirmed that the prediction is based on a direct influence of fatty acid alkyl esters on the TDR signal. The suggested technique appeared potentially suitable for monitoring one of the most important quality attribute of the olive oil in the extraction process.

Source-independent time-domain waveform inversion using convolved wavefields: Application to the encoded multisource waveform inversion

KAUST Repository

Choi, Yun Seok; Alkhalifah, Tariq Ali

2011-01-01

Full waveform inversion requires a good estimation of the source wavelet to improve our chances of a successful inversion. This is especially true for an encoded multisource time-domain implementation, which, conventionally, requires separate

Fault Diagnosis of Rotating Machinery Based on Multisensor Information Fusion Using SVM and Time-Domain Features

Directory of Open Access Journals (Sweden)

Ling-li Jiang

2014-01-01

Full Text Available Multisensor information fusion, when applied to fault diagnosis, the time-space scope, and the quantity of information are expanded compared to what could be acquired by a single sensor, so the diagnostic object can be described more comprehensively. This paper presents a methodology of fault diagnosis in rotating machinery using multisensor information fusion that all the features are calculated using vibration data in time domain to constitute fusional vector and the support vector machine (SVM is used for classification. The effectiveness of the presented methodology is tested by three case studies: diagnostic of faulty gear, rolling bearing, and identification of rotor crack. For each case study, the sensibilities of the features are analyzed. The results indicate that the peak factor is the most sensitive feature in the twelve time-domain features for identifying gear defect, and the mean, amplitude square, root mean square, root amplitude, and standard deviation are all sensitive for identifying gear, rolling bearing, and rotor crack defect comparatively.

Improved theory of time domain reflectometry with variable coaxial cable length for electrical conductivity measurements

Science.gov (United States)

Although empirical models have been developed previously, a mechanistic model is needed for estimating electrical conductivity (EC) using time domain reflectometry (TDR) with variable lengths of coaxial cable. The goals of this study are to: (1) derive a mechanistic model based on multisection tra...

A Spectral Multi-Domain Penalty Method for Elliptic Problems Arising From a Time-Splitting Algorithm For the Incompressible Navier-Stokes Equations

Science.gov (United States)

Diamantopoulos, Theodore; Rowe, Kristopher; Diamessis, Peter

2017-11-01

The Collocation Penalty Method (CPM) solves a PDE on the interior of a domain, while weakly enforcing boundary conditions at domain edges via penalty terms, and naturally lends itself to high-order and multi-domain discretization. Such spectral multi-domain penalty methods (SMPM) have been used to solve the Navier-Stokes equations. Bounds for penalty coefficients are typically derived using the energy method to guarantee stability for time-dependent problems. The choice of collocation points and penalty parameter can greatly affect the conditioning and accuracy of a solution. Effort has been made in recent years to relate various high-order methods on multiple elements or domains under the umbrella of the Correction Procedure via Reconstruction (CPR). Most applications of CPR have focused on solving the compressible Navier-Stokes equations using explicit time-stepping procedures. A particularly important aspect which is still missing in the context of the SMPM is a study of the Helmholtz equation arising in many popular time-splitting schemes for the incompressible Navier-Stokes equations. Stability and convergence results for the SMPM for the Helmholtz equation will be presented. Emphasis will be placed on the efficiency and accuracy of high-order methods.

Hardware architecture design of image restoration based on time-frequency domain computation

Science.gov (United States)

Wen, Bo; Zhang, Jing; Jiao, Zipeng

2013-10-01

The image restoration algorithms based on time-frequency domain computation is high maturity and applied widely in engineering. To solve the high-speed implementation of these algorithms, the TFDC hardware architecture is proposed. Firstly, the main module is designed, by analyzing the common processing and numerical calculation. Then, to improve the commonality, the iteration control module is planed for iterative algorithms. In addition, to reduce the computational cost and memory requirements, the necessary optimizations are suggested for the time-consuming module, which include two-dimensional FFT/IFFT and the plural calculation. Eventually, the TFDC hardware architecture is adopted for hardware design of real-time image restoration system. The result proves that, the TFDC hardware architecture and its optimizations can be applied to image restoration algorithms based on TFDC, with good algorithm commonality, hardware realizability and high efficiency.

Time-domain finite-difference/finite-element hybrid simulations of radio frequency coils in magnetic resonance imaging

International Nuclear Information System (INIS)

Wang Shumin; Duyn, Jeff H

2008-01-01

A hybrid method that combines the finite-difference time-domain (FDTD) method and the finite-element time-domain (FETD) method is presented for simulating radio-frequency (RF) coils in magnetic resonance imaging. This method applies a high-fidelity FETD method to RF coils, while the human body is modeled with a low-cost FDTD method. Since the FDTD and the FETD methods are applied simultaneously, the dynamic interaction between RF coils and the human body is fully accounted for. In order to simplify the treatment of the highly irregular FDTD/FETD interface, composite elements are proposed. Two examples are provided to demonstrate the validity and effectiveness of the hybrid method in high-field receive-and-transmit coil design. This approach is also applicable to general bio-electromagnetic simulations

A framework for assessing frequency domain causality in physiological time series with instantaneous effects.

Science.gov (United States)

Faes, Luca; Erla, Silvia; Porta, Alberto; Nollo, Giandomenico

2013-08-28

We present an approach for the quantification of directional relations in multiple time series exhibiting significant zero-lag interactions. To overcome the limitations of the traditional multivariate autoregressive (MVAR) modelling of multiple series, we introduce an extended MVAR (eMVAR) framework allowing either exclusive consideration of time-lagged effects according to the classic notion of Granger causality, or consideration of combined instantaneous and lagged effects according to an extended causality definition. The spectral representation of the eMVAR model is exploited to derive novel frequency domain causality measures that generalize to the case of instantaneous effects the known directed coherence (DC) and partial DC measures. The new measures are illustrated in theoretical examples showing that they reduce to the known measures in the absence of instantaneous causality, and describe peculiar aspects of directional interaction among multiple series when instantaneous causality is non-negligible. Then, the issue of estimating eMVAR models from time-series data is faced, proposing two approaches for model identification and discussing problems related to the underlying model assumptions. Finally, applications of the framework on cardiovascular variability series and multichannel EEG recordings are presented, showing how it allows one to highlight patterns of frequency domain causality consistent with well-interpretable physiological interaction mechanisms.

Fluorescence lifetime imaging of induced pluripotent stem cells

Science.gov (United States)

Uchugonova, Aisada; Batista, Ana; König, Karsten

2014-02-01

The multiphoton FLIM tomograph MPTflex with its flexible scan head, articulated arm, and the tunable femtosecond laser source was employed to study cell monolayers and 3D cell clusters. FLIM was performed with 250 ps temporal resolution and submicron special resolution using time-correlated single photon counting. The autofluorescence based on NAD(P)H and flavins/flavoproteins has been measured in mouse embryonic fibroblasts, induced pluripotent stem cells (iPS cells) originated from mouse embryonic fibroblasts and non-proliferative mouse embryonic fibroblasts.

The Future of the Time Domain with LSST

Science.gov (United States)

Walkowicz, Lucianne M.

2012-04-01

abstract-type="normal">SummaryIn the coming decade LSST's combination of all-sky coverage, consistent long-term monitoring and flexible criteria for event identification will revolutionize studies of a wide variety of astrophysical phenomena. Time-domain science with LSST encompasses objects both familiar and exotic, from classical variables within our Galaxy to explosive cosmological events. Increased sample sizes of known-but-rare observational phenomena will quantify their distributions for the first time, thus challenging existing theories. Perhaps most excitingly, LSST will provide the opportunity to sample previously untouched regions of parameter space. LSST will generate `alerts' within 60 seconds of detecting a new transient, permitting the community to follow up unusual events in greater detail. However, follow-up will remain a challenge as the volume of transients will easily saturate available spectroscopic resources. Characterization of events and access to appropriate ancillary data (e.g. from prior observations, either in the optical or in other passbands) will be of the utmost importance in prioritizing follow-up observations. The incredible scientific opportunities and unique challenges afforded by LSST demand organization, forethought and creativity from the astronomical community. To learn more about the telescope specifics and survey design, as well as obtaining a overview of the variety of the scientific investigations that LSST will enable, readers are encouraged to look at the LSST Science Book: http://www.lsst.org/lsst/scibook. Organizational details of the LSST science collaborations and management may be found at http://www.lsstcorp.org.

Time-Domain Full-Wave Modeling of Nonlinear Air Breakdown in High-Power Microwave Devices and Systems

Science.gov (United States)

2017-09-30

distribution is unlimited. 13. SUPPLEMENTARY NOTES 14. ABSTRACT This final report describes the effort to develop a discontinuous Galerkin time ...Approved for public release; distribution is unlimited. 1.0 SUMMARY In this report, a discontinuous Galerkin time -domain (DGTD) method is developed...public release; distribution is unlimited. [23] S. Yan, C.-P. Lin, R. R. Arslanbekov, V. I. Kolobov, and J.-M. Jin, “A discontinuous Galerkin time

Refractive Index Sensing of Green Fluorescent Proteins in Living Cells Using Fluorescence Lifetime Imaging Microscopy

Science.gov (United States)

van Manen, Henk-Jan; Verkuijlen, Paul; Wittendorp, Paul; Subramaniam, Vinod; van den Berg, Timo K.; Roos, Dirk; Otto, Cees

2008-01-01

We show that fluorescence lifetime imaging microscopy (FLIM) of green fluorescent protein (GFP) molecules in cells can be used to report on the local refractive index of intracellular GFP. We expressed GFP fusion constructs of Rac2 and gp91phox, which are both subunits of the phagocyte NADPH oxidase enzyme, in human myeloid PLB-985 cells and showed by high-resolution confocal fluorescence microscopy that GFP-Rac2 and GFP-gp91phox are targeted to the cytosol and to membranes, respectively. Frequency-domain FLIM experiments on these PLB-985 cells resulted in average fluorescence lifetimes of 2.70 ns for cytosolic GFP-Rac2 and 2.31 ns for membrane-bound GFP-gp91phox. By comparing these lifetimes with a calibration curve obtained by measuring GFP lifetimes in PBS/glycerol mixtures of known refractive index, we found that the local refractive indices of cytosolic GFP-Rac2 and membrane-targeted GFP-gp91phox are ∼1.38 and ∼1.46, respectively, which is in good correspondence with reported values for the cytosol and plasma membrane measured by other techniques. The ability to measure the local refractive index of proteins in living cells by FLIM may be important in revealing intracellular spatial heterogeneities within organelles such as the plasma and phagosomal membrane. PMID:18223002

Implementation of Unsplit Perfectly Matched Layer Absorbing Boundary Condition in 3 Dimensional Finite Difference Time Domain Method

Directory of Open Access Journals (Sweden)

B. U. Musa

2017-04-01

Full Text Available The C++ programming language was used to implement three-dimensional (3-D finite-difference time-domain (FDTD technique to simulate radiation of high frequency electromagnetic waves in free space. To achieve any meaningful results the computational domain of interest should have to be truncated in some way and this is achieved by applying absorbing boundary conditions. A uniaxial perfectly matched layer (UPML absorbing boundary condition is used in this work. The discretised equations of the UPML in FDTD time stepping scheme were derived and has been successfully implemented using the computer program. Simulation results showed that the UPML behaves as an absorber. This was confirmed by comparing the results with another boundary condition, the Mur ABC.

Separated matter and antimatter domains with vanishing domain walls

Energy Technology Data Exchange (ETDEWEB)

Dolgov, A.D.; Godunov, S.I.; Rudenko, A.S.; Tkachev, I.I., E-mail: dolgov@fe.infn.it, E-mail: sgodunov@itep.ru, E-mail: a.s.rudenko@inp.nsk.su, E-mail: tkachev@ms2.inr.ac.ru [Physics Department and Laboratory of Cosmology and Elementary Particle Physics, Novosibirsk State University, Pirogova st. 2, Novosibirsk, 630090 (Russian Federation)

2015-10-01

We present a model of spontaneous (or dynamical) C and CP violation where it is possible to generate domains of matter and antimatter separated by cosmologically large distances. Such C(CP) violation existed only in the early universe and later it disappeared with the only trace of generated baryonic and/or antibaryonic domains. So the problem of domain walls in this model does not exist. These features are achieved through a postulated form of interaction between inflaton and a new scalar field, realizing short time C(CP) violation.

All-Digital Time-Domain CMOS Smart Temperature Sensor with On-Chip Linearity Enhancement.

Science.gov (United States)

Chen, Chun-Chi; Chen, Chao-Lieh; Lin, Yi

2016-01-30

This paper proposes the first all-digital on-chip linearity enhancement technique for improving the accuracy of the time-domain complementary metal-oxide semiconductor (CMOS) smart temperature sensor. To facilitate on-chip application and intellectual property reuse, an all-digital time-domain smart temperature sensor was implemented using 90 nm Field Programmable Gate Arrays (FPGAs). Although the inverter-based temperature sensor has a smaller circuit area and lower complexity, two-point calibration must be used to achieve an acceptable inaccuracy. With the help of a calibration circuit, the influence of process variations was reduced greatly for one-point calibration support, reducing the test costs and time. However, the sensor response still exhibited a large curvature, which substantially affected the accuracy of the sensor. Thus, an on-chip linearity-enhanced circuit is proposed to linearize the curve and achieve a new linearity-enhanced output. The sensor was implemented on eight different Xilinx FPGA using 118 slices per sensor in each FPGA to demonstrate the benefits of the linearization. Compared with the unlinearized version, the maximal inaccuracy of the linearized version decreased from 5 °C to 2.5 °C after one-point calibration in a range of -20 °C to 100 °C. The sensor consumed 95 μW using 1 kSa/s. The proposed linearity enhancement technique significantly improves temperature sensing accuracy, avoiding costly curvature compensation while it is fully synthesizable for future Very Large Scale Integration (VLSI) system.

Thermal diffusivity of a metallic thin layer using the time-domain thermo reflectance technique

International Nuclear Information System (INIS)

Battaglia, J-L; Kusiak, A; Rossignol, C; Chigarev, N

2007-01-01

The time domain thermo reflectance (TDTR) is widely used in the field of acoustic and thermal characterization of thin layers at the nano and micro scale. In this paper, we propose to derive a simple analytical expression of the thermal diffusivity of the layer. This relation is based on the analytical solution of one-dimensional heat transfer in the medium using integral transforms. For metals, the two-temperature model shows that the capacitance effect at the short times is essentially governed by the electronic contribution

Using terahertz time-domain spectroscopical technique to monitor cocrystal formation between piracetam and 2,5-dihydroxybenzoic acid

Science.gov (United States)

Du, Yong; Xia, Yi; Zhang, Huili; Hong, Zhi

2013-07-01

Far-infrared vibrational absorption of cocrystal formation between 2,5-dihydroxybenzoic acid (2,5-DHBA) and piracetam compounds under solvent evaporation and grinding methods have been investigated using terahertz time-domain spectroscopy (THz-TDS) at room temperature. The experimental results show large difference among absorption spectra of the formed cocrystals and the involved individual parent molecules in 0.20-1.50 THz region, which probably originated from the intra-molecular and inter-molecular hydrogen bonds due to the presence of two hydroxyl groups in 2,5-DHBA and amide moieties in piracetam compound. The THz absorption spectra of two formed cocrystals with different methods are almost identical. With grinding method, the reaction process can be monitored directly from both time-domain and frequency-domain spectra using THz-TDS technique. The results indicate that THz-TDS technology can absolutely offer us a high potential method to identify and characterize the formed cocrystals, and also provide the rich information about their reaction dynamic process involving two or more molecular crystals in situ to better know the corresponding reaction mechanism in pharmaceutical fields.

Integral equation approach to time-dependent kinematic dynamos in finite domains

International Nuclear Information System (INIS)

Xu Mingtian; Stefani, Frank; Gerbeth, Gunter

2004-01-01

The homogeneous dynamo effect is at the root of cosmic magnetic field generation. With only a very few exceptions, the numerical treatment of homogeneous dynamos is carried out in the framework of the differential equation approach. The present paper tries to facilitate the use of integral equations in dynamo research. Apart from the pedagogical value to illustrate dynamo action within the well-known picture of the Biot-Savart law, the integral equation approach has a number of practical advantages. The first advantage is its proven numerical robustness and stability. The second and perhaps most important advantage is its applicability to dynamos in arbitrary geometries. The third advantage is its intimate connection to inverse problems relevant not only for dynamos but also for technical applications of magnetohydrodynamics. The paper provides the first general formulation and application of the integral equation approach to time-dependent kinematic dynamos, with stationary dynamo sources, in finite domains. The time dependence is restricted to the magnetic field, whereas the velocity or corresponding mean-field sources of dynamo action are supposed to be stationary. For the spherically symmetric α 2 dynamo model it is shown how the general formulation is reduced to a coupled system of two radial integral equations for the defining scalars of the poloidal and toroidal field components. The integral equation formulation for spherical dynamos with general stationary velocity fields is also derived. Two numerical examples - the α 2 dynamo model with radially varying α and the Bullard-Gellman model - illustrate the equivalence of the approach with the usual differential equation method. The main advantage of the method is exemplified by the treatment of an α 2 dynamo in rectangular domains

Time-domain modeling for shielding effectiveness of materials against electromagnetic pulse based on system identification

International Nuclear Information System (INIS)

Chen, Xiang; Chen, Yong Guang; Wei, Ming; Hu, Xiao Feng

2013-01-01

Shielding effectiveness (SE) of materials against electromagnetic pulse (EMP) cannot be well estimated by traditional test method of SE of materials which only consider the amplitude-frequency characteristic of materials, but ignore the phase-frequency ones. In order to solve this problem, the model of SE of materials against EMP was established based on system identification (SI) method with time-domain linear cosine frequency sweep signal. The feasibility of the method in this paper was examined depending on infinite planar material and the simulation research of coaxial test method and windowed semi-anechoic box of materials. The results show that the amplitude-frequency and phase-frequency information of each frequency can be fully extracted with this method. SE of materials against strong EMP can be evaluated with time-domain low field strength (voltage) of cosine frequency sweep signal. And SE of materials against a variety EMP will be predicted by the model.

Analysis of time domain active sensing data from CX-100 wind turbine blade fatigue tests for damage assessment

Energy Technology Data Exchange (ETDEWEB)

Choi, Mi Jin [Dept. of Aerospace Engineering and LANL-CBNU Engineering Institute, Chunbuk National University, Jeonju (Korea, Republic of); Jung, Hwee Kwon; Park, Gyu Hae [School of Mechanical Engineering, Chonnam National University, Gwangju (Korea, Republic of); Taylor, Stuart G.; Farinholt, Kevin M. [The Engineering Institute, Los Alamos National Laboratory, Los Alamos (United States)

2016-04-15

This paper presents the results obtained using time-series-based methods for structural damage assessment. The methods are applied to a wind turbine blade structure subjected to fatigue loads. A 9 m CX-100 (carbon experimental 100 kW) blade is harmonically excited at its first natural frequency to introduce a failure mode. Consequently, a through-thickness fatigue crack is visually identified at 8.5 million cycles. The time domain data from the piezoelectric active-sensing techniques are measured during the fatigue loadings and used to detect incipient damage. The damage-sensitive features, such as the first four moments and a normality indicator, are extracted from the time domain data. Time series autoregressive models with exogenous inputs are also implemented. These features could efficiently detect a fatigue crack and are less sensitive to operational variations than the other methods.

Time domain localization technique with sparsity constraint for imaging acoustic sources

Science.gov (United States)

Padois, Thomas; Doutres, Olivier; Sgard, Franck; Berry, Alain

2017-09-01

This paper addresses source localization technique in time domain for broadband acoustic sources. The objective is to accurately and quickly detect the position and amplitude of noise sources in workplaces in order to propose adequate noise control options and prevent workers hearing loss or safety risk. First, the generalized cross correlation associated with a spherical microphone array is used to generate an initial noise source map. Then a linear inverse problem is defined to improve this initial map. Commonly, the linear inverse problem is solved with an l2 -regularization. In this study, two sparsity constraints are used to solve the inverse problem, the orthogonal matching pursuit and the truncated Newton interior-point method. Synthetic data are used to highlight the performances of the technique. High resolution imaging is achieved for various acoustic sources configurations. Moreover, the amplitudes of the acoustic sources are correctly estimated. A comparison of computation times shows that the technique is compatible with quasi real-time generation of noise source maps. Finally, the technique is tested with real data.

Use of the finite-difference time-domain method in electromagnetic dosimetry

International Nuclear Information System (INIS)

Sullivan, D.M.

1987-01-01

Although there are acceptable methods for calculating whole body electromagnetic absorption, no completely acceptable method for calculating the local specific absorption rate (SAR) at points within the body has been developed. Frequency domain methods, such as the method of moments (MoM) have achieved some success; however, the MoM requires computer storage on the order of (3N) 2 , and computation time on the order of (3N) 3 where N is the number of cells. The finite-difference time-domain (FDTD) method has been employed extensively in calculating the scattering from metallic objects, and recently is seeing some use in calculating the interaction of EM fields with complex, lossy dielectric bodies. Since the FDTD method has storage and time requirements proportional to N, it presents an attractive alternative to calculating SAR distribution in large bodies. This dissertation describes the FDTD method and evaluates it by comparing its results with analytic solutions in 2 and 3 dimensions. The results obtained demonstrate that the FDTD method is capable of calculating internal SAR distribution with acceptable accuracy. The construction of a data base to provide detailed, inhomogeneous man models for use with the FDTD method is described. Using this construction method, a model of 40,000 1.31 cm. cells is developed for use at 350 MHz, and another model consisting of 5000 2.62 cm. cells is developed for use at 100 MHz. To add more realism to the problem, a ground plane is added to the FDTD software. The needed changes to the software are described, along with a test which confirms its accuracy. Using the CRAY II supercomputer, SAR distributions in human models are calculated using incident frequencies of 100 MHz and 350 MHz for three different cases: (1) A homogeneous man model in free space, (2) an inhomogeneous man model in free space, and (3) an inhomogeneous man model standing on a ground plane

Mini Tensiometer-Time Domain Reflectometry Coil Probe for Measuring Soil Water Retention Properties

DEFF Research Database (Denmark)

Subedi, Shaphal; Kawamoto, Ken; Karunarathna, Anurudda Kumara

2013-01-01

Time domain reflectometry (TDR) is used widely for measuring soil-water content. New TDR coil probe technology facilitates the development of small, nondestructive probes for simultaneous measurement of soil-water content (θ) and soil-water potential (ψ). In this study we developed mini tensiomet...... between measured soil-water retention curves (ψ > –100 cm H2O) by the new T-TDR coil probes and independent measurements by the hanging water column method....

A combined rheology and time domain NMR approach for determining water distributions in protein blends

NARCIS (Netherlands)

Dekkers, Birgit L.; Kort, de Daan W.; Grabowska, Katarzyna J.; Tian, Bei; As, Van Henk; Goot, van der Atze Jan

2016-01-01

We present a combined time domain NMR and rheology approach to quantify the water distribution in a phase separated protein blend. The approach forms the basis for a new tool to assess the microstructural properties of phase separated biopolymer blends, making it highly relevant for many food and

Time domain analysis of thin-wire antennas over lossy ground using the reflection-coefficient approximation

NARCIS (Netherlands)

Fernández Pantoja, M.; Yarovoy, A.G.; Rubio Bretones, A.; González García, S.

2009-01-01

This paper presents a procedure to extend the methods of moments in time domain for the transient analysis of thin-wire antennas to include those cases where the antennas are located over a lossy half-space. This extended technique is based on the reflection coefficient (RC) approach, which

Transient analysis of printed lines using finite-difference time-domain method

Energy Technology Data Exchange (ETDEWEB)

Ahmed, Shahid [Thomas Jefferson National Accelerator Facility, 12050 Jefferson Avenue, Suite 704, Newport News, VA, 23606, USA

2012-03-29

Comprehensive studies of ultra-wideband pulses and electromagnetic coupling on printed coupled lines have been performed using full-wave 3D finite-difference time-domain analysis. Effects of unequal phase velocities of coupled modes, coupling between line traces, and the frequency dispersion on the waveform fidelity and crosstalk have been investigated in detail. To discriminate the contributions of different mechanisms into pulse evolution, single and coupled microstrip lines without (ϵ_r = 1) and with (ϵ_r > 1) dielectric substrates have been examined. To consistently compare the performance of the coupled lines with substrates of different permittivities and transients of different characteristic times, a generic metric similar to the electrical wavelength has been introduced. The features of pulse propagation on coupled lines with layered and pedestal substrates and on the irregular traces have been explored. Finally, physical interpretations of the simulation results are discussed in the paper.

Retarded potentials and time domain boundary integral equations a road map

CERN Document Server

Sayas, Francisco-Javier

2016-01-01

This book offers a thorough and self-contained exposition of the mathematics of time-domain boundary integral equations associated to the wave equation, including applications to scattering of acoustic and elastic waves. The book offers two different approaches for the analysis of these integral equations, including a systematic treatment of their numerical discretization using Galerkin (Boundary Element) methods in the space variables and Convolution Quadrature in the time variable. The first approach follows classical work started in the late eighties, based on Laplace transforms estimates. This approach has been refined and made more accessible by tailoring the necessary mathematical tools, avoiding an excess of generality. A second approach contains a novel point of view that the author and some of his collaborators have been developing in recent years, using the semigroup theory of evolution equations to obtain improved results. The extension to electromagnetic waves is explained in one of the appendices...

A general framework for time series data mining based on event analysis: application to the medical domains of electroencephalography and stabilometry.

Science.gov (United States)

Lara, Juan A; Lizcano, David; Pérez, Aurora; Valente, Juan P

2014-10-01

There are now domains where information is recorded over a period of time, leading to sequences of data known as time series. In many domains, like medicine, time series analysis requires to focus on certain regions of interest, known as events, rather than analyzing the whole time series. In this paper, we propose a framework for knowledge discovery in both one-dimensional and multidimensional time series containing events. We show how our approach can be used to classify medical time series by means of a process that identifies events in time series, generates time series reference models of representative events and compares two time series by analyzing the events they have in common. We have applied our framework on time series generated in the areas of electroencephalography (EEG) and stabilometry. Framework performance was evaluated in terms of classification accuracy, and the results confirmed that the proposed schema has potential for classifying EEG and stabilometric signals. The proposed framework is useful for discovering knowledge from medical time series containing events, such as stabilometric and electroencephalographic time series. These results would be equally applicable to other medical domains generating iconographic time series, such as, for example, electrocardiography (ECG). Copyright © 2014 Elsevier Inc. All rights reserved.

A Combined Time Domain Impedance Probe And Plasma Wave Receiver System For Small Satellite Applications.

Science.gov (United States)

Spencer, E. A.; Clark, D. C.; Vadepu, S. K.; Patra, S.

2017-12-01

A Time Domain Impedance Probe (TDIP) measures electron density and electron neutral collision frequencies in the ionosphere. This instrument has been tested on a sounding rocket flight and is now being further developed to fly on a NASA Undergraduate Student Instrument Program (USIP) cubesat to be launched out of the ISS in 2019. Here we report on the development of a new combined TDIP and plasma wave instrument that can be used on cubesat platforms to measure local electron parameters, and also to receive or transmit electron scale waves. This combined instrument can be used to study short time and space scale phenomena in the upper ionosphere using only RF signals. The front end analog circuitry is dual-purposed to perform active or passive probing of the ambient plasma. Two dipole antennas are used, one is optimzed for impedance measurements, while the other is optimized for transmitter-receiver performance. We show our circuit realization, and initial results from laboratory measurements using the TDIP prototype modified for receiver function. We also show Finite Difference Time Domain (FDTD) simulations of an electrically long antenna immersed in a magnetized plasma used to optimize the transmitter receiver performance.

Improved control for distributed parameter systems with time-dependent spatial domains utilizing mobile sensor–actuator networks

International Nuclear Information System (INIS)

Zhang Jian-Zhong; Cui Bao-Tong; Zhuang Bo

2017-01-01

A guidance policy for controller performance enhancement utilizing mobile sensor–actuator networks (MSANs) is proposed for a class of distributed parameter systems (DPSs), which are governed by diffusion partial differential equations (PDEs) with time-dependent spatial domains. Several sufficient conditions for controller performance enhancement are presented. First, the infinite dimensional operator theory is used to derive an abstract evolution equation of the systems under some rational assumptions on the operators, and a static output feedback controller is designed to control the spatial process. Then, based on Lyapunov stability arguments, guidance policies for collocated and non-collocated MSANs are provided to enhance the performance of the proposed controller, which show that the time-dependent characteristic of the spatial domains can significantly affect the design of the mobile scheme. Finally, a simulation example illustrates the effectiveness of the proposed policy. (paper)

Inspection of Asian Lacquer Substructures by Terahertz Time-Domain Imaging (THz-TDI)

DEFF Research Database (Denmark)

Dandolo, Corinna Ludovica Koch; Fukunaga, Kaori; Kohzuma, Yoshei

2017-01-01

Lacquering is considered one of the most representative Asian artistic techniques. While the decorative part of lacquerwares is the lacquer itself, their substructures serve as the backbone of the object itself. Very little is known about these hidden substructures. Since lacquerwares are mostly...... by inspecting the substructures of Asian lacquerwares by means of THz time-domain imaging (THz-TDI). Three different kinds of Asian lacquerwares were examined by THz-TDI, and the outcomes have been compared with those obtained by standard X-radiography. THz-TDI provides unique information on lacquerwares...

Dielectric relaxation and hydrogen bonding interaction in xylitol-water mixtures using time domain reflectometry

Science.gov (United States)

Rander, D. N.; Joshi, Y. S.; Kanse, K. S.; Kumbharkhane, A. C.

2016-01-01

The measurements of complex dielectric permittivity of xylitol-water mixtures have been carried out in the frequency range of 10 MHz-30 GHz using a time domain reflectometry technique. Measurements have been done at six temperatures from 0 to 25 °C and at different weight fractions of xylitol (0 xylitol-water can be well described by Cole-Davidson model having an asymmetric distribution of relaxation times. The dielectric parameters such as static dielectric constant and relaxation time for the mixtures have been evaluated. The molecular interaction between xylitol and water molecules is discussed using the Kirkwood correlation factor ( g eff ) and thermodynamic parameter.

Data Mining and Machine Learning in Time-Domain Discovery and Classification

Science.gov (United States)

Bloom, Joshua S.; Richards, Joseph W.

2012-03-01

The changing heavens have played a central role in the scientific effort of astronomers for centuries. Galileo's synoptic observations of the moons of Jupiter and the phases of Venus starting in 1610, provided strong refutation of Ptolemaic cosmology. These observations came soon after the discovery of Kepler's supernova had challenged the notion of an unchanging firmament. In more modern times, the discovery of a relationship between period and luminosity in some pulsational variable stars [41] led to the inference of the size of the Milky way, the distance scale to the nearest galaxies, and the expansion of the Universe (see Ref. [30] for review). Distant explosions of supernovae were used to uncover the existence of dark energy and provide a precise numerical account of dark matter (e.g., [3]). Repeat observations of pulsars [71] and nearby main-sequence stars revealed the presence of the first extrasolar planets [17,35,44,45]. Indeed, time-domain observations of transient events and variable stars, as a technique, influences a broad diversity of pursuits in the entire astronomy endeavor [68]. While, at a fundamental level, the nature of the scientific pursuit remains unchanged, the advent of astronomy as a data-driven discipline presents fundamental challenges to the way in which the scientific process must now be conducted. Digital images (and data cubes) are not only getting larger, there are more of them. On logistical grounds, this taxes storage and transport systems. But it also implies that the intimate connection that astronomers have always enjoyed with their data - from collection to processing to analysis to inference - necessarily must evolve. Figure 6.1 highlights some of the ways that the pathway to scientific inference is now influenced (if not driven by) modern automation processes, computing, data-mining, and machine-learning (ML). The emerging reliance on computation and ML is a general one - a central theme of this book - but the time-domain

Analysis of oscillational instabilities in acoustic levitation using the finite-difference time-domain method

DEFF Research Database (Denmark)

Santillan, Arturo Orozco

2011-01-01

The aim of the work described in this paper has been to investigate the use of the finite-difference time-domain method to describe the interactions between a moving object and a sound field. The main objective was to simulate oscillational instabilities that appear in single-axis acoustic...... levitation devices and to describe their evolution in time to further understand the physical mechanism involved. The study shows that the method gives accurate results for steady state conditions, and that it is a promising tool for simulations with a moving object....

Time-resolved imaging of domain pattern destruction and recovery via nonequilibrium magnetization states

Science.gov (United States)

Wessels, Philipp; Ewald, Johannes; Wieland, Marek; Nisius, Thomas; Vogel, Andreas; Viefhaus, Jens; Meier, Guido; Wilhein, Thomas; Drescher, Markus

2014-11-01

The destruction and formation of equilibrium multidomain patterns in permalloy (Ni80Fe20 ) microsquares has been captured using pump-probe x-ray magnetic circular dichroism (XMCD) spectromicroscopy at a new full-field magnetic transmission soft x-ray microscopy endstation with subnanosecond time resolution. The movie sequences show the dynamic magnetization response to intense Oersted field pulses of approximately 200-ps root mean square (rms) duration and the magnetization reorganization to the ground-state domain configuration. The measurements display how a vortex flux-closure magnetization distribution emerges out of a nonequilibrium uniform single-domain state. During the destruction of the initial vortex pattern, we have traced the motion of the central vortex core that is ejected out of the microsquare at high velocities exceeding 1 km/s. A reproducible recovery into a defined final vortex state with stable chirality and polarity could be achieved. Using an additional external bias field, the transient reversal of the square magnetization direction could be monitored and consistently reproduced by micromagnetic simulations.

Landfill cover performance monitoring using time domain reflectometry

International Nuclear Information System (INIS)

Neher, E.R.; Cotten, G.B.; McElroy, D.

1998-01-01

Time domain reflectometry (TDR) systems were installed to monitor soil moisture in two newly constructed landfill covers at the Idaho National Engineering and Environmental Laboratory. Each TDR system includes four vertical arrays with each array consisting of four TDR probes located at depths of 15, 30, 45, and 60 cm. The deepest probes at 60 cm were installed beneath a compacted soil layer to analyze infiltration through the compacted layer. Based on the TDR data, infiltration through the two covers between March and October, 1997 ranged from less than measurable to 1.5 cm. However, due to a prohibition on penetrating the buried waste and resulting limits on probe placement depths, deeper percolation was not evaluated. Some of the advantages found in the application of TDR for infiltration monitoring at this site are the relative low cost and rugged nature of the equipment. Also, of particular importance, the ability to collect frequent moisture measurements allows the capture and evaluation of soil moisture changes resulting from episodic precipitation events. Disadvantages include the inability to install the probes into the waste, difficulties in interpretation of infiltration during freeze/thaw periods, and some excessive noise in the data

Time domain numerical calculations of the short electron bunch wakefields in resistive structures

Energy Technology Data Exchange (ETDEWEB)

Tsakanian, Andranik

2010-10-15

The acceleration of electron bunches with very small longitudinal and transverse phase space volume is one of the most actual challenges for the future International Linear Collider and high brightness X-Ray Free Electron Lasers. The exact knowledge on the wake fields generated by the ultra-short electron bunches during its interaction with surrounding structures is a very important issue to prevent the beam quality degradation and to optimize the facility performance. The high accuracy time domain numerical calculations play the decisive role in correct evaluation of the wake fields in advanced accelerators. The thesis is devoted to the development of a new longitudinally dispersion-free 3D hybrid numerical scheme in time domain for wake field calculation of ultra short bunches in structures with walls of finite conductivity. The basic approaches used in the thesis to solve the problem are the following. For materials with high but finite conductivity the model of the plane wave reflection from a conducting half-space is used. It is shown that in the conductive half-space the field components perpendicular to the interface can be neglected. The electric tangential component on the surface contributes to the tangential magnetic field in the lossless area just before the boundary layer. For high conducting media, the task is reduced to 1D electromagnetic problem in metal and the so-called 1D conducting line model can be applied instead of a full 3D space description. Further, a TE/TM (''transverse electric - transverse magnetic'') splitting implicit numerical scheme along with 1D conducting line model is applied to develop a new longitudinally dispersion-free hybrid numerical scheme in the time domain. The stability of the new hybrid numerical scheme in vacuum, conductor and bound cell is studied. The convergence of the new scheme is analyzed by comparison with the well-known analytical solutions. The wakefield calculations for a number of

Non-Invasive Detection of Adulterated Olive Oil in Full Bottles Using Time-Domain NMR Relaxometry

OpenAIRE

Santos, Poliana M.; Kock, Flávio Vinicius C.; Santos, Maiara S.; Lobo, Carlos Manuel S.; Carvalho, André S.; Colnago, Luiz Alberto

2017-01-01

A fast procedure using time-domain nuclear magnetic resonance (TD-NMR) to detect olive oil adulteration with polyunsaturated vegetable oils in filled bottles is proposed. The 1H transverse relaxation times (T2) of 37 commercial samples were measured using low-field nuclear magnetic resonance (LF-NMR) spectrometer and a unilateral nuclear magnetic resonance (UNMR) sensor. Results obtained with LF-NMR revealed better feasibility when compared with the UNMR sensor, with higher signal-to-noise (S...

Application of Time Domain PARET to the measured responses of a building

International Nuclear Information System (INIS)

Lager, D.L.

1979-01-01

The application of the Time Domain PARET (TDP) algorithm to data obtained from the measured responses of a three story reinforced concrete building approximately 465 feet long by 220 feet wide by 40 feet high, with 12 to 18 inch thick walls, is described. The measurements were taken by Agbabian Associates, El Segundo, California. The structure was excited by a device developed at Agbabian that uses a mass sliding down a rod to cut metal disks attached to the rod. The result is a series of impulse forces driving the building at the attachment point of the rod. The responses measured were the accelerations at two locations on the structure. A constraint imposed was that the equipment in the building must remain operating during the time the measurements were made

Non-contact acquisition of respiration and heart rates using Doppler radar with time domain peak-detection algorithm.

Science.gov (United States)

Xiaofeng Yang; Guanghao Sun; Ishibashi, Koichiro

2017-07-01

The non-contact measurement of the respiration rate (RR) and heart rate (HR) using a Doppler radar has attracted more attention in the field of home healthcare monitoring, due to the extremely low burden on patients, unconsciousness and unconstraint. Most of the previous studies have performed the frequency-domain analysis of radar signals to detect the respiration and heartbeat frequency. However, these procedures required long period time (approximately 30 s) windows to obtain a high-resolution spectrum. In this study, we propose a time-domain peak detection algorithm for the fast acquisition of the RR and HR within a breathing cycle (approximately 5 s), including inhalation and exhalation. Signal pre-processing using an analog band-pass filter (BPF) that extracts respiration and heartbeat signals was performed. Thereafter, the HR and RR were calculated using a peak position detection method, which was carried out via LABVIEW. To evaluate the measurement accuracy, we measured the HR and RR of seven subjects in the laboratory. As a reference of HR and RR, the persons wore contact sensors i.e., an electrocardiograph (ECG) and a respiration band. The time domain peak-detection algorithm, based on the Doppler radar, exhibited a significant correlation coefficient of HR of 0.92 and a correlation coefficient of RR of 0.99, between the ECG and respiration band, respectively.

Time-domain electromagnetic soundings at the Nevada Test Site, Nevada

International Nuclear Information System (INIS)

Frischknecht, F.C.; Raab, P.V.

1984-01-01

Structural discontinuities and variations in the resistivity of near-surface rocks often seriously distort dc resistivity and frequency-domain electromagnetic (FDEM) depth sounding curves. Reliable interpretation of such curves using one-dimensional (1-D) models is difficult or impossible. Short-offset time-domain electromagnetic (TDEM) sounding methods offer a number of advantages over other common geoelectrical sounding methods when working in laterally heterogeneous areas. In order to test the TDEM method in a geologically complex region, measurements were made on the east flank of Yucca Mountain at the Nevada Test Site (NTS). Coincident, offset coincident, single, and central loop configurations with square transmitting loops, either 305 or 152 m on a side, were used. Measured transient voltages were transformed into apparent resistivity values and then inverted in terms of 1-D models. Good fits to all of the offset coincident and single loop data were obtained using three-layer models. In most of the area, two well-defined interfaces were mapped, one which corresponds closely to a contact between stratigraphic units at a depth of about 400 m and another which corresponds to a transition from relatively unaltered to altered volcanic rocks at a depth of about 1000 m. In comparison with the results of a dipole-dipole resistivity survey, the results of the TDEM survey emphasize changes in the geoelectrical section with depth. Nonetheless, discontinuities in the layering mapped with the TDEM method delineated major faults or fault zones along the survey traverse. 5 refs., 10 figs., 1 tab

Relations between the development of future time perspective in three life domains, investment in learning, and academic achievement

NARCIS (Netherlands)

Peetsma, T.; van der Veen, I.

2011-01-01

Relations between the development of future time perspectives in three life domains (i.e., school and professional career, social relations, and leisure time) and changes in students’ investment in learning and academic achievement were examined in this study. Participants were 584 students in the

Quantifying NMR relaxation correlation and exchange in articular cartilage with time domain analysis

Science.gov (United States)

Mailhiot, Sarah E.; Zong, Fangrong; Maneval, James E.; June, Ronald K.; Galvosas, Petrik; Seymour, Joseph D.

2018-02-01

Measured nuclear magnetic resonance (NMR) transverse relaxation data in articular cartilage has been shown to be multi-exponential and correlated to the health of the tissue. The observed relaxation rates are dependent on experimental parameters such as solvent, data acquisition methods, data analysis methods, and alignment to the magnetic field. In this study, we show that diffusive exchange occurs in porcine articular cartilage and impacts the observed relaxation rates in T1-T2 correlation experiments. By using time domain analysis of T2-T2 exchange spectroscopy, the diffusive exchange time can be quantified by measurements that use a single mixing time. Measured characteristic times for exchange are commensurate with T1 in this material and so impacts the observed T1 behavior. The approach used here allows for reliable quantification of NMR relaxation behavior in cartilage in the presence of diffusive fluid exchange between two environments.

CALCULATION OF CONTROL CIRCUITS IN TIME DOMAIN USING SCILAB / XCOS ENVIRONMENT

Directory of Open Access Journals (Sweden)

Chioncel Petru

2014-10-01

Full Text Available The paper presents the computing of control circuits in time domain, starting from the mathematical model of the control path described by differential equation’s with constant coefficients, whose solution can be obtained through Laplace transform and transfer functions. In the field of electric drives, the control circuits can be reduced to elements of PT1 and PT2 type, for which, the responses obtained from step and impulse function in the test process, are analyzed. The presented calculation, done in Scilab, highlights the test responses of the process and, the speed control circuit implemented as block diagrams in Xcos, reveals the improve of the process parameter through the control loop.

Resistivity structures imaging using time-domain electromagnetic data; TDEM ho ni yoru chika hiteiko kozo no imaging

Energy Technology Data Exchange (ETDEWEB)

Noguchi, K [Waseda University, Tokyo (Japan). School of Science and Engineering; Endo, M [Waseda University, Tokyo (Japan)

1996-10-01

The kernel function for transient vertical magnetic dipole was defined for semi-infinite uniform medium, and the 1-D imaging algorithm by TDEM (time-domain electromagnetic) method was developed for underground resistivity structure. Electromagnetic migration method directly images sectional resistivity profiles from the data observed by frequency-domain MT method, and determines underground resistivity profiles by integral equation of MT field using the concept of return travel time in reflection seismic exploration. The method reported in this paper is also one of the EM migration methods. The imaging algorithm of 2-D resistivity structure was developed by correcting 1-D imaging in consideration of the effect of 2-D anomaly on 1-D imaging (the resistivity of anomaly can be obtained from the resistivity contrast between anomaly and medium). The conventional methods require enormous forward computation, while this method can obtain underground resistivity structure in extremely short computation time, resulting in superior practicability. 12 refs., 7 figs.

Time domain reshuffling for OFDM based indoor visible light communication systems.

Science.gov (United States)

You, Xiaodi; Chen, Jian; Yu, Changyuan; Zheng, Huanhuan

2017-05-15

For orthogonal frequency division multiplexing (OFDM) based indoor visible light communication (VLC) systems, partial non-ideal transmission conditions such as insufficient guard intervals and a dispersive channel can result in severe inter-symbol crosstalk (ISC). By deriving from the inverse Fourier transform, we present a novel time domain reshuffling (TDR) concept for both DC-biased optical (DCO-) and asymmetrically clipped optical (ACO-) OFDM VLC systems. By using only simple operations in the frequency domain, potential high peaks can be relocated within each OFDM symbol to alleviate ISC. To simplify the system, we also propose an effective unified design of the TDR schemes for both DCO- and ACO-OFDM. Based on Monte-Carlo simulations, we demonstrate the statistical distribution of the signal high peak values and the complementary cumulative distribution function of the peak-to-average power ratio under different cases for comparison. Simulation results indicate improved bit error rate (BER) performance by adopting TDR to counteract ISC deterioration. For example, for binary phase shift keying at a BER of 10 -3 , the signal to noise ratio gains are ~1.6 dB and ~6.6 dB for DCO- and ACO-OFDM, respectively, with ISC of 1/64. We also show a reliable transmission by adopting TDR for rectangle 8-quadrature amplitude modulation with ISC of < 1/64.

A reaction time advantage for calculating beliefs over public representations signals domain specificity for 'theory of mind'.

Science.gov (United States)

Cohen, Adam S; German, Tamsin C

2010-06-01

In a task where participants' overt task was to track the location of an object across a sequence of events, reaction times to unpredictable probes requiring an inference about a social agent's beliefs about the location of that object were obtained. Reaction times to false belief situations were faster than responses about the (false) contents of a map showing the location of the object (Experiment 1) and about the (false) direction of an arrow signaling the location of the object (Experiment 2). These results are consistent with developmental, neuro-imaging and neuropsychological evidence that there exist domain specific mechanisms within human cognition for encoding and reasoning about mental states. Specialization of these mechanisms may arise from either core cognitive architecture or via the accumulation of expertise in the social domain.

On the DC loop modes in the MOT solution of the time domain EFIE

KAUST Repository

Shi, Yifei; Bagci, Hakan; Lu, Mingyu

2014-01-01

When marching-on-in-time (MOT) method is applied to solve the time domain electric field integral equation (TD-EFIE), DC loop modes are always observed in the solution. In theory these modes should not be observed since they do not satisfy the relaxed initial conditions. Their appearance is attributed to numerical errors. It is shown here that when Rao-Wilton-Glisson basis and Lagrange interpolation functions are used to discretize the TD-EFIE, errors due to this space-time discretization have zero impact on the DC loop modes. Numerical experiments demonstrate that the numerical errors due to approximate solution of the MOT matrix system have more dominant impact on DC loop modes in the MOT solution.

Time domain simulation of the response of geometrically nonlinear panels subjected to random loading

Science.gov (United States)

Moyer, E. Thomas, Jr.

1988-01-01

The response of composite panels subjected to random pressure loads large enough to cause geometrically nonlinear responses is studied. A time domain simulation is employed to solve the equations of motion. An adaptive time stepping algorithm is employed to minimize intermittent transients. A modified algorithm for the prediction of response spectral density is presented which predicts smooth spectral peaks for discrete time histories. Results are presented for a number of input pressure levels and damping coefficients. Response distributions are calculated and compared with the analytical solution of the Fokker-Planck equations. RMS response is reported as a function of input pressure level and damping coefficient. Spectral densities are calculated for a number of examples.

On the DC loop modes in the MOT solution of the time domain EFIE

KAUST Repository

Shi, Yifei

2014-07-01

When marching-on-in-time (MOT) method is applied to solve the time domain electric field integral equation (TD-EFIE), DC loop modes are always observed in the solution. In theory these modes should not be observed since they do not satisfy the relaxed initial conditions. Their appearance is attributed to numerical errors. It is shown here that when Rao-Wilton-Glisson basis and Lagrange interpolation functions are used to discretize the TD-EFIE, errors due to this space-time discretization have zero impact on the DC loop modes. Numerical experiments demonstrate that the numerical errors due to approximate solution of the MOT matrix system have more dominant impact on DC loop modes in the MOT solution.

Terahertz time-domain attenuated total reflection spectroscopy applied to the rapid discrimination of the botanical origin of honeys

Science.gov (United States)

Liu, Wen; Zhang, Yuying; Yang, Si; Han, Donghai

2018-05-01

A new technique to identify the floral resources of honeys is demanded. Terahertz time-domain attenuated total reflection spectroscopy combined with chemometrics methods was applied to discriminate different categorizes (Medlar honey, Vitex honey, and Acacia honey). Principal component analysis (PCA), cluster analysis (CA) and partial least squares-discriminant analysis (PLS-DA) have been used to find information of the botanical origins of honeys. Spectral range also was discussed to increase the precision of PLS-DA model. The accuracy of 88.46% for validation set was obtained, using PLS-DA model in 0.5-1.5 THz. This work indicated terahertz time-domain attenuated total reflection spectroscopy was an available approach to evaluate the quality of honey rapidly.

Wavefield Extrapolation in Pseudo-depth Domain

KAUST Repository

Ma, Xuxin

2011-12-11

Wave-equation based seismic migration and inversion tools are widely used by the energy industry to explore hydrocarbon and mineral resources. By design, most of these techniques simulate wave propagation in a space domain with the vertical axis being depth measured from the surface. Vertical depth is popular because it is a straightforward mapping of the subsurface space. It is, however, not computationally cost-effective because the wavelength changes with local elastic wave velocity, which in general increases with depth in the Earth. As a result, the sampling per wavelength also increases with depth. To avoid spatial aliasing in deep fast media, the seismic wave is oversampled in shallow slow media and therefore increase the total computation cost. This issue is effectively tackled by using the vertical time axis instead of vertical depth. This is because in a vertical time representation, the "wavelength" is essentially time period for vertical rays. This thesis extends the vertical time axis to the pseudo-depth axis, which features distance unit while preserving the properties of the vertical time representation. To explore the potentials of doing wave-equation based imaging in the pseudo-depth domain, a Partial Differential Equation (PDE) is derived to describe acoustic wave in this new domain. This new PDE is inherently anisotropic because the use of a constant vertical velocity to convert between depth and vertical time. Such anisotropy results in lower reflection coefficients compared with conventional space domain modeling results. This feature is helpful to suppress the low wavenumber artifacts in reverse-time migration images, which are caused by the widely used cross-correlation imaging condition. This thesis illustrates modeling acoustic waves in both conventional space domain and pseudo-depth domain. The numerical tool used to model acoustic waves is built based on the lowrank approximation of Fourier integral operators. To investigate the potential

Experimental demonstration of bandwidth on demand (BoD) provisioning based on time scheduling in software-defined multi-domain optical networks