pacientes con falla cardiaca

Directory of Open Access Journals (Sweden)

Diana Marcela Achury Saldaña

2007-01-01

Full Text Available Objetivo: determinar la adherencia al tratamiento de pacientes con falla cardiaca hospitalizados, al aplicar un plan educativo quefomenta el autocuidado.Método: estudio cuasiexperimental (entrevistas enfermera-paciente realizado entre diciembre de 2004 y mayo de 2006, con unamuestra de 50 pacientes seleccionados por conveniencia. Se diseñó un instrumento para evaluar los comportamientos de los pacientes,con base en algunos resultados de la adherencia y sus respectivos indicadores de la taxonomía NOC (Nursing out comes classification. Laadherencia al tratamiento fue medida en dos momentos: el primero durante la hospitalización, seguido de la aplicación del plan educativoantes del alta, que proporcionaba información en el manejo de su enfermedad desde una dimensión física, psicológica y social quepromueve el autocuidado; y el segundo un mes después del alta en su domicilio.Resultados: diferencias estadísticamente significativas (P=0,0001 que demuestran cómo mediante la capacitación al paciente enel manejo de su tratamiento farmacológico y no farmacológico, el establecimiento de una sana relación entre el profesional de enfermeríay el paciente, y la participación de la familia, se logra una total adherencia al tratamiento.Conclusiones: para lograr una adherencia total del paciente con falla cardiaca al tratamiento es necesario un proceso educativo y unseguimiento continuo y personalizado que motive permanentemente al paciente y se le reconozca el papel protagónico en su cuidado y manejo de la enfermedad.

There are those who call it...TIM

CERN Multimedia

2007-01-01

To boldly go where people can't... The Train Inspection Monorail, affectionately referred to as 'TIM,' will allow scientists, technicians and engineers to view and take measurements in the LHC tunnel when it is inaccessible to humans. TIM in the tunnel.Jean-Louis Grenard, who designed TIM's mechanical components, uses the portable remote control station to put the TIM through its paces at Point 1 in the LHC. Imagine being able to view parts of the LHC before people are allowed into the tunnel after the beam has been circulating...or to accurately measure the position of equipment in areas with the highest levels of radiation without risking human exposure. The Train Inspection Monorail, or 'TIM' to its closer friends, is a modular train that will run along the ceiling of the LHC tunnel, helping many groups on site to address the problems of inspecting, measuring and even handling equipment in the LHC when radiation levels and cryogenic hazards will restrict personnel access to the tunnel. TIM was developed ...

Falla ovárica precoz

OpenAIRE

José Pacheco

2010-01-01

La falla ovárica precoz es una amenorrea secundaria que se presenta en una mujer antes de los 40 años, que conlleva a hipoestrogenismo, infertilidad y las consecuencias de la menopausia prematura, como osteoporosis, enfermedad cardiovascular, trastornos neurovegetativos, entre otros. Se presenta agotamiento folicular, por dotación insuficiente de folículos o destrucción acelerada de los ovocitos. Las causas son varias, pero predominan las genéticas, autoinmunes y las iatrogénicas. Entre las c...

Las principales fallas de motores eléctricos en Costa Rica

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Osvaldo Guerreo Castro

2010-10-01

Full Text Available Una de las tareas más importantes en la gestión del mantenimiento de los equipos de producción, y particularmente de los motores eléctricos, es identificar y prevenir las fallas para tomar acciones que eviten la incidencia de las mismas.Mediante una investigación de campo, con visitas a empresas de varios sectoresproductivos y talleres de reparación de motores eléctricos en Costa Rica, se logróobtener una clasificación y distribución porcentual de las fallas más comunes enlos motores trifásicos de inducción, en el rango de 2 a 50 HP.Esta investigación determinó que existen cuatro tipos de fallas más comunes enmotores eléctricos en Costa Rica; estas se concentran en dos sectores productivos.La investigación identificó aspectos relevantes por mejorar en cuanto a la orientación de la formación profesional universitaria y, en el modelo administrativo del mantenimiento de estos equipos, en lasindustrias.

Tim Berners-Lee during the WSIS

CERN Multimedia

Maximilien Brice

2003-01-01

Tim Berners-Lee stands in front of the first web server at the Geneva Palexpo during the World Summit on the Information Society (WSIS) in 2003. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

Falla cardiaca, tratamiento: diuréticos, inhibidores de la ECA y nitratos

OpenAIRE

Guillermo Trout Guardiola

2013-01-01

En los pasados 15 años grandes ensayos clínicos randomizados, controlados, han revolucionado el manejo de pacientes con falla cardiaca. Aunque es claro que algunas drogas mejoran los síntomas, otras presentan beneficios pronósticos y sintomáticos, el manejo de falla cardiaca se debe centralizar en mejorar la calidad de vida y la sobrevida. Los diuréticos y los inhibidores de la enzima convertidora de la angiotensina, combinados con medidas no farmacologicas, permanecen como el tratamiento con...

Capítulo 2. Introducción, epidemiología de la falla cardiaca e historia de las clínicas de falla cardiaca en Colombia

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Efraín Gómez

2016-03-01

Conclusión: Las clínicas de falla cardiaca surgieron en Colombia en 1985. Desde entonces se cuenta con varios programas en ciudades como Bogotá, Medellín, Cali y Bucaramanga que ofrecen la opción de seguimiento multidisciplinario por Enfermería y Cardiología, e incluso muchas de ellas tienen programas de trasplante de corazón. Sin embargo, el reto actual para todos los programas es continuar creciendo e integrándose con los niveles básicos de atención para permitir intervenir desde la prevención, el diagnóstico temprano y el tratamiento adecuado de la falla cardiaca.

TIM-1 signaling in B cells regulates antibody production

International Nuclear Information System (INIS)

Ma, Juan; Usui, Yoshihiko; Takeda, Kazuyoshi; Harada, Norihiro; Yagita, Hideo; Okumura, Ko; Akiba, Hisaya

2011-01-01

Highlights: → TIM-1 is highly expressed on anti-IgM + anti-CD40-stimulated B cells. → Anti-TIM-1 mAb enhanced proliferation and Ig production on activated B cell in vitro. → TIM-1 signaling regulates Ab production by response to TI-2 and TD antigens in vivo. -- Abstract: Members of the T cell Ig and mucin (TIM) family have recently been implicated in the control of T cell-mediated immune responses. In this study, we found TIM-1 expression on anti-IgM- or anti-CD40-stimulated splenic B cells, which was further up-regulated by the combination of anti-IgM and anti-CD40 Abs. On the other hand, TIM-1 ligand was constitutively expressed on B cells and inducible on anti-CD3 + anti-CD28-stimulated CD4 + T cells. In vitro stimulation of activated B cells by anti-TIM-1 mAb enhanced proliferation and expression of a plasma cell marker syndecan-1 (CD138). We further examined the effect of TIM-1 signaling on antibody production in vitro and in vivo. Higher levels of IgG2b and IgG3 secretion were detected in the culture supernatants of the anti-TIM-1-stimulated B cells as compared with the control IgG-stimulated B cells. When immunized with T-independent antigen TNP-Ficoll, TNP-specific IgG1, IgG2b, and IgG3 Abs were slightly increased in the anti-TIM-1-treated mice. When immunized with T-dependent antigen OVA, serum levels of OVA-specific IgG2b, IgG3, and IgE Abs were significantly increased in the anti-TIM-1-treated mice as compared with the control IgG-treated mice. These results suggest that TIM-1 signaling in B cells augments antibody production by enhancing B cell proliferation and differentiation.

TIM-1 signaling in B cells regulates antibody production

Energy Technology Data Exchange (ETDEWEB)

Ma, Juan [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Usui, Yoshihiko [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishi-shinjuku-ku, Tokyo 160-0023 (Japan); Takeda, Kazuyoshi [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Harada, Norihiro [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Department of Respiratory Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Research Institute for Diseases of Old Ages, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Yagita, Hideo; Okumura, Ko [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Akiba, Hisaya, E-mail: hisaya@juntendo.ac.jp [Department of Immunology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan)

2011-03-11

Highlights: {yields} TIM-1 is highly expressed on anti-IgM + anti-CD40-stimulated B cells. {yields} Anti-TIM-1 mAb enhanced proliferation and Ig production on activated B cell in vitro. {yields} TIM-1 signaling regulates Ab production by response to TI-2 and TD antigens in vivo. -- Abstract: Members of the T cell Ig and mucin (TIM) family have recently been implicated in the control of T cell-mediated immune responses. In this study, we found TIM-1 expression on anti-IgM- or anti-CD40-stimulated splenic B cells, which was further up-regulated by the combination of anti-IgM and anti-CD40 Abs. On the other hand, TIM-1 ligand was constitutively expressed on B cells and inducible on anti-CD3{sup +} anti-CD28-stimulated CD4{sup +} T cells. In vitro stimulation of activated B cells by anti-TIM-1 mAb enhanced proliferation and expression of a plasma cell marker syndecan-1 (CD138). We further examined the effect of TIM-1 signaling on antibody production in vitro and in vivo. Higher levels of IgG2b and IgG3 secretion were detected in the culture supernatants of the anti-TIM-1-stimulated B cells as compared with the control IgG-stimulated B cells. When immunized with T-independent antigen TNP-Ficoll, TNP-specific IgG1, IgG2b, and IgG3 Abs were slightly increased in the anti-TIM-1-treated mice. When immunized with T-dependent antigen OVA, serum levels of OVA-specific IgG2b, IgG3, and IgE Abs were significantly increased in the anti-TIM-1-treated mice as compared with the control IgG-treated mice. These results suggest that TIM-1 signaling in B cells augments antibody production by enhancing B cell proliferation and differentiation.

Characterizing Functional Domains for TIM-Mediated Enveloped Virus Entry

Science.gov (United States)

Moller-Tank, Sven; Albritton, Lorraine M.; Rennert, Paul D.

2014-01-01

ABSTRACT T-cell immunoglobulin and mucin domain 1 (TIM-1) and other TIM family members were recently identified as phosphatidylserine (PtdSer)-mediated virus entry-enhancing receptors (PVEERs). These proteins enhance entry of Ebola virus (EBOV) and other viruses by binding PtdSer on the viral envelope, concentrating virus on the cell surface, and promoting subsequent internalization. The PtdSer-binding activity of the immunoglobulin-like variable (IgV) domain is essential for both virus binding and internalization by TIM-1. However, TIM-3, whose IgV domain also binds PtdSer, does not effectively enhance virus entry, indicating that other domains of TIM proteins are functionally important. Here, we investigate the domains supporting enhancement of enveloped virus entry, thereby defining the features necessary for a functional PVEER. Using a variety of chimeras and deletion mutants, we found that in addition to a functional PtdSer-binding domain PVEERs require a stalk domain of sufficient length, containing sequences that promote an extended structure. Neither the cytoplasmic nor the transmembrane domain of TIM-1 is essential for enhancing virus entry, provided the protein is still plasma membrane bound. Based on these defined characteristics, we generated a mimic lacking TIM sequences and composed of annexin V, the mucin-like domain of α-dystroglycan, and a glycophosphatidylinositol anchor that functioned as a PVEER to enhance transduction of virions displaying Ebola, Chikungunya, Ross River, or Sindbis virus glycoproteins. This identification of the key features necessary for PtdSer-mediated enhancement of virus entry provides a basis for more effective recognition of unknown PVEERs. IMPORTANCE T-cell immunoglobulin and mucin domain 1 (TIM-1) and other TIM family members are recently identified phosphatidylserine (PtdSer)-mediated virus entry-enhancing receptors (PVEERs). These proteins enhance virus entry by binding the phospholipid, PtdSer, present on the viral

Tim Berners-Lee receives the Millennium Technology Prize

CERN Multimedia

2004-01-01

On 15 April, for his invention of the Web, Tim Berners-Lee was awarded the first ever Millennium Technology Prize by the Finnish Technology Award Foundation, which recognises technological innovations of lasting benefit to society. "Tim Berners-Lee's invention perfectly encapsulates the spirit of the Prize. The Web is encouraging new types of social networks, contributing to transparency and democracy, and opening up new avenues for information management and business development," underlined Pekka Tarjanne, chairman of the jury and former Secretary-General of the International Telecommunication Union (ITU). Tim Berners-Lee is congratulated by Jukka Valtasaari, Finland's Ambassador to the United States. Tim Berners-Lee created the first server, browser and editor, the HTML code, the URL address and the HTTP transmission protocol at CERN in 1990. CERN released the Web into the public domain in 1993. Tim Berners-Lee is currently head of the World Wide Web Consortium, managed by ERCIM (Europe...

Diferencias de género en el tratamiento de la falla cardíaca

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Clara Saldarriaga

2014-02-01

Full Text Available INTRODUCCIÓN: la falla cardíaca representa un problema creciente de salud con una alta prevalencia en el sexo femenino; sin embargo, no se han reportado estudios en población de mujeres latinoamericanas que permitan identificar si existen diferencias de género tanto en la presentación clínica como en el tratamiento de esta patología. OBJETIVO: evaluar si existen diferencias tanto en las características clínicas y epidemiológicas como en el manejo farmacológico en función del género, en una serie de pacientes con falla cardíaca atendidos en un centro de referencia cardiovascular en Colombia. METODOLOGÍA: estudio observacional, descriptivo, que evaluó a todos los pacientes hospitalizados por síndrome de falla cardiaca como diagnóstico principal durante julio de 2009 y julio de 2010 en un centro de referencia cardiovascular colombiano. RESULTADOS: se incluyeron 204 pacientes, 36,7% de sexo femenino, cuya edad promedio fue mayor en las mujeres; la fracción de eyección promedio fue similar. Las mujeres tenían falla renal con mayor frecuencia. Se encontró menor uso de betabloqueadores, así como de implante de cardiodesfibrilador. CONCLUSIÓN: para la población estudiada se encontró que existen diferencias entre ambos sexos tanto en las variables demográficas como clínicas. A pesar de presentar mayores comorbilidades, las mujeres con falla cardiaca reciben con menor frecuencia terapias como los betabloqueadores y el cardiodesfibrilador implantable que han demostrado disminuir la mortalidad. Es necesario ampliar el conocimiento de las diferencias de género mediante la creación de un registro multicéntrico latinoamericano que permita incidir en la toma de decisiones clínicas propias para la región.

Preliminary crystallographic studies of yeast mitochondrial peripheral membrane protein Tim44p

Energy Technology Data Exchange (ETDEWEB)

Josyula, Ratnakar [Department of Cell Biology, Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham (United States); Jin, Zhongmin [SER-CAT, APS, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States); McCombs, Deborah; DeLucas, Lawrence [Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham (United States); Sha, Bingdong, E-mail: bdsha@uab.edu [Department of Cell Biology, Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham (United States)

2006-02-01

Tim44p is an essential mitochondrial peripheral membrane protein. To investigate the mechanism by which Tim44p functions in the TIM23 translocon to deliver the mitochondrial protein precursors, the yeast Tim44p has been crystallized. Protein translocations across mitochondrial membranes play critical roles in mitochondrion biogenesis. Protein transport from the cell cytosol to the mitochondrial matrix is carried out by the translocase of the outer membrane (TOM) complex and the translocase of the inner membrane (TIM) complexes. Tim44p is an essential mitochondrial peripheral membrane protein and a major component of the TIM23 translocon. To investigate the mechanism by which Tim44p functions in the TIM23 translocon to deliver the mitochondrial protein precursors, the yeast Tim44p was crystallized. The crystals diffract to 3.2 Å using a synchrotron X-ray source and belong to space group P6{sub 3}22, with unit-cell parameters a = 124.25, c = 77.83 Å. There is one Tim44p molecule in one asymmetric unit, which corresponds to a solvent content of approximately 43%. Structure determination by MAD methods is under way.

Role of the Phosphatidylserine Receptor TIM-1 in Enveloped-Virus Entry

Science.gov (United States)

Moller-Tank, Sven; Kondratowicz, Andrew S.; Davey, Robert A.; Rennert, Paul D.

2013-01-01

The cell surface receptor T cell immunoglobulin mucin domain 1 (TIM-1) dramatically enhances filovirus infection of epithelial cells. Here, we showed that key phosphatidylserine (PtdSer) binding residues of the TIM-1 IgV domain are critical for Ebola virus (EBOV) entry through direct interaction with PtdSer on the viral envelope. PtdSer liposomes but not phosphatidylcholine liposomes competed with TIM-1 for EBOV pseudovirion binding and transduction. Further, annexin V (AnxV) substituted for the TIM-1 IgV domain, supporting a PtdSer-dependent mechanism. Our findings suggest that TIM-1-dependent uptake of EBOV occurs by apoptotic mimicry. Additionally, TIM-1 enhanced infection of a wide range of enveloped viruses, including alphaviruses and a baculovirus. As further evidence of the critical role of enveloped-virion-associated PtdSer in TIM-1-mediated uptake, TIM-1 enhanced internalization of pseudovirions and virus-like proteins (VLPs) lacking a glycoprotein, providing evidence that TIM-1 and PtdSer-binding receptors can mediate virus uptake independent of a glycoprotein. These results provide evidence for a broad role of TIM-1 as a PtdSer-binding receptor that mediates enveloped-virus uptake. Utilization of PtdSer-binding receptors may explain the wide tropism of many of these viruses and provide new avenues for controlling their virulence. PMID:23698310

Análisis de falla en evaporadores de placas de aluminio de sistemas de acondicionamiento de aire automotriz

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Santiago Mendoza Hurtado

2011-01-01

Full Text Available Se caracterizaron los tipos de fallas a partir del estudio de tres perfiles de evaporadores de placas de aleación de aluminio, puestos fuera de servicio por fugas del refrigerante y obtenidos en talleres de refrigeración automotriz en la ciudad de Barranquilla. Luego se aplicaron las pruebas de la metodología del análisis de falla. Se comprobó que los mecanismos de falla fueron principalmente corrosión con algunas situaciones tendientes a fractura frágil; además, las condiciones ambientales de la ciudad de Barranquilla son factores influyentes en los mecanismos de corrosión.

Paul Schwabe | NREL

Science.gov (United States)

. Cory, and J. Newcomb. 2009. Renewable Energy Project Financing: Impacts of the Financial Crisis and Schwabe Photo of Paul Schwabe Paul Schwabe Project Manager IV-Research Paul.Schwabe@nrel.gov | 303 . Cory, K. and P. Schwabe. 2009. Wind Levelized Cost of Energy: A Comparison of Technical and Financing

Análisis de falla por fractura en tuberías de conducción de petróleo

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Héctor Hernández A.

1991-03-01

Full Text Available Una sobre presión en una tubería puede ser tal que se presente una falla por inestabilidad plástica. Para cuando se encuentra una discontinuidad la presión de falla se puede reducir ostensiblemente en especial cuando se tienen fenómenos de fragilidad lo cual no es extraño en uniones soldadas. Las discontinuidades pueden provenir del material, como son las deslaminaciones, o generadas en procesos de soldadura como son inclusiones de escoria y porosidades. Con un tiempo prolongado de servicio una falta de penetración en una soldadura puede producir fenómenos de corrosión por estancamiento reduciéndose la sección resistente hasta obtenerse una condición crítica de falla por fractura. En este trabajo en primer término se presentan conceptos teóricos de falla por inestabilidad plástica en recipientes a presión de pared delgada los cuales son confrontados con los resultados de modelo experimental de laboratorio y en segundo término mediante conceptos de mecánica de fractura se presenta la condición de falla para cuando se cuenta con la presencia de un defecto tipo grieta. Con un modelo de tubería de aluminio se muestra que con una presión fluctuante baja una grieta puede crecer a un tamaño crítico de falla después de un determinado número de ciclos de presión.

El uso de bloques tridimensionales en la comprensión de estructuras afectadas por fallas

OpenAIRE

Lillo Beviá, José; Redonet Álvarez, Luisa Fernanda; Riveiro Rubial, José

1988-01-01

Se presenta un modelo de bloques desmontables sobre los que se pueden su proponer diversos planos correspondientes a distintas estructuras geológicas, y se comprueba como quedan afectadas por diversos modelos de fallas. Cada bloque fallado está compuesto por unidades superponibles que permiten visualizar el proceso inicial del momento en que se produce la falla y el proceso final después de haber actuado los procesos erosivos. Este estadio final corresponde a la situación de la...

Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer

Science.gov (United States)

Gao, Quanli; Yuan, Peng; Zhao, Peng; Yuan, Huijuan; Fan, Huijie; Li, Tiepeng; Qin, Peng; Han, Lu; Fang, Weijia; Suo, Zhenhe

2015-01-01

T-cell exhaustion represents a progressive loss of T-cell function. The inhibitory receptor PD-1 is known to negatively regulate CD8+ T cell responses directed against tumor antigen, but the blockades of PD-1 pathway didn't show the objective responses in patients with colorectal cancer (CRC). Thus, further exploring the molecular mechanism responsible for inducing T-cell dysfunction in CRC patients may reveal effective strategies for immune therapy. This study aims to characterize co-inhibitory receptors on T cells in CRC patients to identify novel targets for immunotherapy. In this study, peripheral blood samples from 20 healthy controls and 54 consented CRC patients, and tumor and matched paraneoplastic tissues from 7 patients with advanced CRC, subjected to multicolor flow cytometric analysis of the expression of PD-1 and Tim-3 receptors on CD8+ T cells. It was found that CRC patients presented with significantly higher levels of circulating Tim-3+PD-1+CD8+ T cells compared to the healthy controls (medians of 3.12% and 1.99%, respectively, p = 0.0403). A similar increase of Tim-3+PD-1+CD8+ T cells was also observed in the tumor tissues compared to paraneoplastic tussues. Tim-3+PD-1+CD8+ T cells in tumor tissues produced even less cytokine than that in paraneoplastic tissues. Functional ex vivo experiments showed that Tim-3+PD-1+CD8+ T cells produced significantly less IFN-γ than Tim-3−PD-1−CD8+ T cells, followed by Tim-3+PD-1−CD8+ T cells, and Tim-3−PD-1+CD8+ T cells, indicating a stronger inhibition of IFN-γ production of Tim-3+CD8+ T cells. It is also found in this study that Tim-3+PD-1+CD8+ T cell increase in circulation was correlated with clinical cancer stage but not histologic grade and serum concentrations of cancer biomarker CEA. Our results indicate that upregulation of the inhibitory receptor Tim-3 may restrict T cell responses in CRC patients, and therefore blockage of Tim-3 and thus restoring T cell responses may be a potential

Taming dendritic cells with TIM-3: Another immunosuppressive strategy by tumors

Science.gov (United States)

Patel, Jaina; Bozeman, Erica N.; Selvaraj, Periasamy

2013-01-01

The identification of TIM-3 expression on tumor associated dendritic cells (TADCs) provides insight into another aspect of tumor-mediated immunosuppression. The role of TIM-3 has been well characterized on tumor-infiltrating T cells, however its role on TADCs was not previously known. The current paper demonstrated that TIM-3 was predominantly expressed by TADCs and its interaction with the nuclear protein HMGB1 suppressed nucleic acid mediated activation of an effective antitumor immune response. The authors were able to show that TIM-3 interaction with HMGB1 prevented the localization of nucleic acids into endosomal vesicles. Furthermore, chemotherapy was found to be more effective in anti-TIM-3 mAb treated mice or mice depleted of all DCs which indicated that significant role played by TADCs inhibiting tumor regression. Taken together, these findings identify TIM-3 as a potential target for inducing antitumor immunity in conjunction with DNA vaccines and/or immunogenic chemotherapy in clinical settings. PMID:23240746

Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways.

LENUS (Irish Health Repository)

Vega-Carrascal, Isabel

2012-02-01

The T-cell Ig and mucin domain-containing molecules (TIMs) have emerged as promising therapeutic targets to correct abnormal immune function in several autoimmune and chronic inflammatory conditions. It has been reported that proinflammatory cytokine dysregulation and neutrophil-dominated inflammation are the main causes of morbidity in cystic fibrosis (CF). However, the role of TIM receptors in CF has not been investigated. In this study, we demonstrated that TIM-3 is constitutively overexpressed in the human CF airway, suggesting a link between CF transmembrane conductance regulator (CFTR) function and TIM-3 expression. Blockade of CFTR function with the CFTR inhibitor-172 induced an upregulation of TIM-3 and its ligand galectin-9 in normal bronchial epithelial cells. We also established that TIM-3 serves as a functional receptor in bronchial epithelial cells, and physiologically relevant concentrations of galectin-9 induced TIM-3 phosphorylation, resulting in increased IL-8 production. In addition, we have demonstrated that both TIM-3 and galectin-9 undergo rapid proteolytic degradation in the CF lung, primarily because of neutrophil elastase and proteinase-3 activity. Our results suggest a novel intrinsic defect that may contribute to the neutrophil-dominated immune response in the CF airways.

Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways.

LENUS (Irish Health Repository)

Vega-Carrascal, Isabel

2011-03-01

The T-cell Ig and mucin domain-containing molecules (TIMs) have emerged as promising therapeutic targets to correct abnormal immune function in several autoimmune and chronic inflammatory conditions. It has been reported that proinflammatory cytokine dysregulation and neutrophil-dominated inflammation are the main causes of morbidity in cystic fibrosis (CF). However, the role of TIM receptors in CF has not been investigated. In this study, we demonstrated that TIM-3 is constitutively overexpressed in the human CF airway, suggesting a link between CF transmembrane conductance regulator (CFTR) function and TIM-3 expression. Blockade of CFTR function with the CFTR inhibitor-172 induced an upregulation of TIM-3 and its ligand galectin-9 in normal bronchial epithelial cells. We also established that TIM-3 serves as a functional receptor in bronchial epithelial cells, and physiologically relevant concentrations of galectin-9 induced TIM-3 phosphorylation, resulting in increased IL-8 production. In addition, we have demonstrated that both TIM-3 and galectin-9 undergo rapid proteolytic degradation in the CF lung, primarily because of neutrophil elastase and proteinase-3 activity. Our results suggest a novel intrinsic defect that may contribute to the neutrophil-dominated immune response in the CF airways.

RED NEURONAL PARA LA CLASIFICACIÓN DE FALLAS EN LÍNEAS DE TRANSMISIÓN A PARTIR DE REGISTROS DE OSCILOPERTURBOGRAFÍA

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JHON ALBEIRO CALDERÓN

2008-01-01

Full Text Available El diagnóstico de fallas eléctricas en líneas de transmisión a alto voltaje es una tarea compleja no solo por la cantidad de información involucrada que puede provenir de diversas fuentes como SOE, SCADA y registradores, si no también por la variabilidad misma de las fallas. Dicha complejidad impacta en la oportunidad y certeza del diagnóstico, factores particularmente importantes para el análisis en tiempo real donde rápidamente deben tomarse pautas adecuadas para el restablecimiento del sistema eléctrico de potencia. En este artículo se propone el uso de de una red neuronal con aprendizaje por regularización bayesiana y finalización temprana para la clasificación de fallas a partir de registros de osciloperturbografía provenientes de registradores de falla y se muestra su efectividad para una amplia variedad de casos de entrenamiento y validación, los cuales son obtenidos por medio de un modelo de ATP con el cual se simularon la cantidad de fallas eléctricas requeridas.

Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting.

Science.gov (United States)

Chacinska, Agnieszka; van der Laan, Martin; Mehnert, Carola S; Guiard, Bernard; Mick, David U; Hutu, Dana P; Truscott, Kaye N; Wiedemann, Nils; Meisinger, Chris; Pfanner, Nikolaus; Rehling, Peter

2010-01-01

Mitochondrial import of cleavable preproteins occurs at translocation contact sites, where the translocase of the outer membrane (TOM) associates with the presequence translocase of the inner membrane (TIM23) in a supercomplex. Different views exist on the mechanism of how TIM23 mediates preprotein sorting to either the matrix or inner membrane. On the one hand, two TIM23 forms were proposed, a matrix transport form containing the presequence translocase-associated motor (PAM; TIM23-PAM) and a sorting form containing Tim21 (TIM23(SORT)). On the other hand, it was reported that TIM23 and PAM are permanently associated in a single-entity translocase. We have accumulated distinct transport intermediates of preproteins to analyze the translocases in their active, preprotein-carrying state. We identified two different forms of active TOM-TIM23 supercomplexes, TOM-TIM23(SORT) and TOM-TIM23-PAM. These two supercomplexes do not represent separate pathways but are in dynamic exchange during preprotein translocation and sorting. Depending on the signals of the preproteins, switches between the different forms of supercomplex and TIM23 are required for the completion of preprotein import.

Prevención de las fallas de los motores trifásicos de inducción mediante una adecuada selección

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Osvaldo Guerreo Castro

2010-10-01

Full Text Available En este trabajo se expone los aspectos de mayor importancia a considerar enuna adecuada selección de motores para prevenir las fallas, así como lasrepercusiones que puede tener tanto en la operación del equipo, como en la cantidad, frecuencia y tipo de falla de los motores trifásicos de inducción.Primeramente, se expondrán los aspectos que prevalecen o se usan con mayorfrecuencia en la selección de un motor trifásico de inducción y otros aspectosque se deben analizar con el cuidado correspondiente y que no se consideranpara prevenir las fallas de estos equipos.No se pretende que este trabajo sea una guía en la selección de motores eléctricos, ya que existen otros aspectos a tomar en cuenta que no serán analizados, sin embargo, sirve de complemento, especialmente si se pretende prevenir las fallas de estos equipos desde su compra.En este trabajo se expone los aspectos de mayor importancia a considerar en una adecuada selección de motores para prevenir las fallas, así como las repercusiones que puede tener tanto en la operación del equipo, como en la cantidad, frecuencia y tipo de falla de los motores trifásicos de inducción.Primeramente, se expondrán los aspectos que prevalecen o se usan con mayorfrecuencia en la selección de un motor trifásico de inducción y otros aspectoque se deben analizar con el cuidado correspondiente y que no se consideranpara prevenir las fallas de estos equipos. No se pretende que este trabajo sea una guía en la selección de motores eléctricos, ya que existen otros aspectos a tomar en cuenta que no serán analizados, sin embargo, sirve de complemento, especialmente si se pretende prevenir las fallas de estos equipos desde su compra.

Cooperation of TOM and TIM23 complexes during translocation of proteins into mitochondria.

Science.gov (United States)

Waegemann, Karin; Popov-Čeleketić, Dušan; Neupert, Walter; Azem, Abdussalam; Mokranjac, Dejana

2015-03-13

Translocation of the majority of mitochondrial proteins from the cytosol into mitochondria requires the cooperation of TOM and TIM23 complexes in the outer and inner mitochondrial membranes. The molecular mechanisms underlying this cooperation remain largely unknown. Here, we present biochemical and genetic evidence that at least two contacts from the side of the TIM23 complex play an important role in TOM-TIM23 cooperation in vivo. Tim50, likely through its very C-terminal segment, interacts with Tom22. This interaction is stimulated by translocating proteins and is independent of any other TOM-TIM23 contact known so far. Furthermore, the exposure of Tim23 on the mitochondrial surface depends not only on its interaction with Tim50 but also on the dynamics of the TOM complex. Destabilization of the individual contacts reduces the efficiency of import of proteins into mitochondria and destabilization of both contacts simultaneously is not tolerated by yeast cells. We conclude that an intricate and coordinated network of protein-protein interactions involving primarily Tim50 and also Tim23 is required for efficient translocation of proteins across both mitochondrial membranes. Copyright © 2014 Elsevier Ltd. All rights reserved.

TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine.

Directory of Open Access Journals (Sweden)

Stephanie Jemielity

2013-03-01

Full Text Available Human T-cell Immunoglobulin and Mucin-domain containing proteins (TIM1, 3, and 4 specifically bind phosphatidylserine (PS. TIM1 has been proposed to serve as a cellular receptor for hepatitis A virus and Ebola virus and as an entry factor for dengue virus. Here we show that TIM1 promotes infection of retroviruses and virus-like particles (VLPs pseudotyped with a range of viral entry proteins, in particular those from the filovirus, flavivirus, New World arenavirus and alphavirus families. TIM1 also robustly enhanced the infection of replication-competent viruses from the same families, including dengue, Tacaribe, Sindbis and Ross River viruses. All interactions between TIM1 and pseudoviruses or VLPs were PS-mediated, as demonstrated with liposome blocking and TIM1 mutagenesis experiments. In addition, other PS-binding proteins, such as Axl and TIM4, promoted infection similarly to TIM1. Finally, the blocking of PS receptors on macrophages inhibited the entry of Ebola VLPs, suggesting that PS receptors can contribute to infection in physiologically relevant cells. Notably, infection mediated by the entry proteins of Lassa fever virus, influenza A virus and SARS coronavirus was largely unaffected by TIM1 expression. Taken together our data show that TIM1 and related PS-binding proteins promote infection of diverse families of enveloped viruses, and may therefore be useful targets for broad-spectrum antiviral therapies.

La teoría de los lazos inductivos y las fallas de los transformadores de distribución en Colombia

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Francisco Román Campos

1991-05-01

Full Text Available Este artículo tiene por objeto presentar la Teoría de los Lazos Inductivos - TU - como una metodología de trabajo coherente para analizar las fallas de los transformadores de distribución en Colombia. Como variables fundamentales en la formulación de la teoría se considera la relación entre las fallas y las tormentas eléctricas; el área dejada en el montaje entre el pararrayos y el transformador y los cambios de impedancia al operar el pararrayo. Paracomprobar la teoría se analiza la relación de las fallas de los transformadores con las tormentas eléctricas en varias redes de distribución en Colombia. Igualmente se establece una primera relación entre rayos medidos y clasificados por polaridad y las fallas de unidades en el mismo período. Los resultados de los análisis estadísticos de másde 3.000 unidades falladas contribuyen a inferir la aplicabilidad de la teoria, por cuanto se encontraron más de un 70% de fallas involucrando tres fases. Se presentan finalmente las primeras simulaciones digitales mediante el EMPT,de las que se concluye la necesidad de adoptar medidas remediables adecuadas a la realidad colombiana.

Tim Berners-Lee, World Wide Web inventor

CERN Multimedia

1994-01-01

Former physicist, Tim Berners-Lee invented the World Wide Web as an essential tool for high energy physics at CERN from 1989 to 1994. Together with a small team he conceived HTML, http, URLs, and put up the first server and the first 'what you see is what you get' browser and html editor. Tim is now Director of the Web Consortium W3C, the International Web standards body based at INRIA, MIT and Keio University.

Aplicando Tolerancia a Fallas para la Implementación de Compensación de Saturación en Accionadores

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Wilber Acuña-Bravo

2008-07-01

Full Text Available Resumen: En esta contribución se presenta un método para la implementación práctica de sistemas de control con compensación de saturación en los actuadores. La técnica se aplica en sistemas lineales, tomando como base un mecanismo de diagnóstico y detección de fallas. Para ello, la saturación en los actuadores es considerada como una falla en el sistema de control, la cual es detectada y aislada mediante un banco de filtros de diagnóstico de fallas, cuyos residuos son utilizados para efectuar la compensación de la saturación, proporcionando un esquema de control tolerante a esta falla particular. Así, el método exhibe ciertas propiedades de robustez frente a cambios en el funcionamiento de los actuadores. Para la síntesis de los filtros de detección de fallas se propone un método derivado de las técnicas de control óptimo robusto en H2/H∞, basado en desigualdades lineales matriciales. Para verificar las propiedades de la tećnica propuesta se presenta un ejemplo numeŕico. Palabras clave: Control tolerante a fallas, compensación anti-windup, filtros de detección defallas, desigualdades lineales matriciales

Taming dendritic cells with TIM-3: another immunosuppressive strategy used by tumors.

Science.gov (United States)

Patel, Jaina; Bozeman, Erica N; Selvaraj, Periasamy

2012-12-01

Evaluation of: Chiba S, Baghdadi M, Akiba H et al. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat. Immunol. 13, 832-842 (2012). The identification of TIM-3 expression on tumor-associated dendritic cells (TADCs) provides insight into another aspect of tumor-mediated immunosuppression. The role of TIM-3 has been well characterized on tumor-infiltrating T cells; however, its role on TADCs was not previously known. The current paper demonstrated that TIM-3 was predominantly expressed by TADCs and its interaction with the nuclear protein HMGB1 suppressed nucleic acid-mediated activation of an effective antitumor immune response. The authors were able to show that TIM-3 interaction with HMGB1 prevented the localization of nucleic acids into endosomal vesicles. Furthermore, chemotherapy was found to be more effective in anti-TIM-3 monoclonal antibody-treated mice or mice depleted of all DCs, which indicated that a significant role is played by TADCs in inhibiting tumor regression. Taken together, these findings identify TIM-3 as a potential target for inducing antitumor immunity in conjunction with DNA vaccines and/or immunogenic chemotherapy in clinical settings.

The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry.

Science.gov (United States)

Meertens, Laurent; Carnec, Xavier; Lecoin, Manuel Perera; Ramdasi, Rasika; Guivel-Benhassine, Florence; Lew, Erin; Lemke, Greg; Schwartz, Olivier; Amara, Ali

2012-10-18

Dengue viruses (DVs) are responsible for the most medically relevant arboviral diseases. However, the molecular interactions mediating DV entry are poorly understood. We determined that TIM and TAM proteins, two receptor families that mediate the phosphatidylserine (PtdSer)-dependent phagocytic removal of apoptotic cells, serve as DV entry factors. Cells poorly susceptible to DV are robustly infected after ectopic expression of TIM or TAM receptors. Conversely, DV infection of susceptible cells is inhibited by anti-TIM or anti-TAM antibodies or knockdown of TIM and TAM expression. TIM receptors facilitate DV entry by directly interacting with virion-associated PtdSer. TAM-mediated infection relies on indirect DV recognition, in which the TAM ligand Gas6 acts as a bridging molecule by binding to PtdSer within the virion. This dual mode of virus recognition by TIM and TAM receptors reveals how DVs usurp the apoptotic cell clearance pathway for infectious entry. Copyright © 2012 Elsevier Inc. All rights reserved.

Tim-3 Up-regulation in Patients with Gastric Cancer and Peptic Ulcer Disease

Science.gov (United States)

Naghavi-Alhosseini, Mahdieh; Tehrani, Mohsen; Ajami, Abolghasem; Rafiei, Alireza; Taghvaei, Tarang; Vahedi-Larijani, Laleh; Hossein-Nataj, Hadi; Asgarian-Omran, Hossein

2017-01-01

Background: T-cell immunoglobulin and mucin domain protein-3 (Tim-3), an inhibitory immunoregulatory receptor, has been recently implicated in tumor biology and tumor-associated immune suppression. In the present study, expression of Tim-3 was evaluated in gastric cancer (GC) and peptic ulcer disease (PUD) at both mRNA and protein levels. Methods: A total of 133 gastric tissue biopsies, comprising 43 from GC cases, 48 from PUD and 42 from non-ulcer dyspepsia (NUD) serving as controls were collected. Additionally, non-neoplastic adjacent tissue biopsies were also obtained from 6 patients with GC. Infection with Helicobacter pylori was determined by the rapid urease test for all participants and H&E staining was conducted for GC and PUD patients. Tim-3 relative mRNA expression was determined by SYBR Green based Real-Time PCR using β-actin as a reference gene. Tim-3 protein expression was also studied by immunohistochemistry in 7 GC, 7 PUD and 10 NUD tissue samples. Results: Tim-3 was expressed at higher levels in GC (p=0.030) and PUD (p=0.022) cases compared to he NUD group. Among paired samples obtained from gastric cancer patients, tumor tissues showed elevated Tim-3 expression (p=0.019) in comparison with adjacent non-neoplastic biopsies. Tim-3 mRNA findings were supported by detection of more Tim-3 protein in cancerous (p=0.002) and ulcerative (p=0.01) tissues than in controls. Tim-3 was similarly expressed in H. pylori positive and negative cases. Conclusion: Higher Tim-3 expression in patients with gastric cancer and peptic ulcer implies that it might be involved in immune regulation and establishment of these gastrointestinal diseases. Targeted immunotherapy by blocking of inhibitory receptors like Tim-3 could be a promising approach for gastric cancer treatment. PMID:28441784

Analysis of TIMS performance subjected to simulated wind blast

Science.gov (United States)

Jaggi, S.; Kuo, S.

1992-01-01

The results of the performance of the Thermal Infrared Multispectral Scanner (TIMS) when it is subjected to various wind conditions in the laboratory are described. Various wind conditions were simulated using a 24 inch fan or combinations of air jet streams blowing toward either or both of the blackbody surfaces. The fan was used to simulate a large volume of air flow at moderate speeds (up to 30 mph). The small diameter air jets were used to probe TIMS system response in reaction to localized wind perturbations. The maximum nozzle speed of the air jet was 60 mph. A range of wind directions and speeds were set up in the laboratory during the test. The majority of the wind tests were conducted under ambient conditions with the room temperature fluctuating no more than 2 C. The temperature of the high speed air jet was determined to be within 1 C of the room temperature. TIMS response was recorded on analog tape. Additional thermistor readouts of the blackbody temperatures and thermocouple readout of the ambient temperature were recorded manually to be compared with the housekeeping data recorded on the tape. Additional tests were conducted under conditions of elevated and cooled room temperatures. The room temperature was varied between 19.5 to 25.5 C in these tests. The calibration parameters needed for quantitative analysis of TIMS data were first plotted on a scanline-by-scanline basis. These parameters are the low and high blackbody temperature readings as recorded by the TIMS and their corresponding digitized count values. Using these values, the system transfer equations were calculated. This equation allows us to compute the flux for any video count by computing the slope and intercept of the straight line that relates the flux to the digital count. The actual video of the target (the lab floor in this case) was then compared with a simulated target. This simulated target was assumed to be a blackbody at emissivity of .95 degrees and the temperature was

Tim Berners-Lee and Kofi Annan during the WSIS

CERN Multimedia

Patrice Loïez

2003-01-01

During the 2003 World Summit on the Information Society (WSIS) at Geneva Palexpo, Tim Berners-Lee W3C's director (World Wide Web consortium) was introduced to Kofi Annan, Secretary General of the United Nations. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

Tim Berners-Lee and Kofi Annan during the WSIS

CERN Multimedia

Patrice Loïez

2003-01-01

During the 2003 World Summit on the Information Society (WSIS) at Geneva Palexpo, Tim Berners-Lee, W3C's director (World Wide Web consortium) was introduced to Kofi Annan, Secretary General of the United Nations. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

Architecture of the TIM23 inner mitochondrial translocon and interactions with the matrix import motor.

Science.gov (United States)

Ting, See-Yeun; Schilke, Brenda A; Hayashi, Masaya; Craig, Elizabeth A

2014-10-10

Translocation of proteins from the cytosol across the mitochondrial inner membrane is driven by action of the matrix-localized multi-subunit import motor, which is associated with the TIM23 translocon. The architecture of the import apparatus is not well understood. Here, we report results of site-specific in vivo photocross-linking along with genetic and coimmunoprecipitation analyses dissecting interactions between import motor subunits and the translocon. The translocon is composed of the two integral membrane proteins Tim23 and Tim17, each containing four membrane-spanning segments. We found that Tim23 having a photoactivatable cross-linker in the matrix exposed loop between transmembrane domains 1 and 2 (loop 1) cross-linked to Tim44. Alterations in this loop destabilized interaction of Tim44 with the translocon. Analogously, Tim17 having a photoactivatable cross-linker in the matrix exposed loop between transmembrane segments 1 and 2 (loop 1) cross-linked to Pam17. Alterations in this loop caused destabilization of the interaction of Pam17 with the translocon. Substitution of individual photoactivatable residues in Tim44 and Pam17 in regions we previously identified as important for translocon association resulted in cross-linking to Tim23 and Tim17, respectively. Our results are consistent with a model in which motor association is achieved via interaction of Tim23 with Tim44, which serves as a scaffold for association of other motor components, and of Tim17 with Pam17. As both Tim44 and Pam17 have been implicated as regulatory subunits of the motor, this positioning is conducive for responding to conformational changes in the translocon upon a translocating polypeptide entering the channel. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Ubicación única de fallas en sistemas de distribución por medio de zonas con SVM

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Germán Morales España

2009-01-01

Full Text Available Este artículo presenta una nueva metodología para localizar fallas en sistemas de distribución por medio de una técnica de inteligencia artificial -Máquinas de Soporte Vectorial-(SVM. El método de localización de la falla se basa en la división del sistema eléctrico en zonas, acotando cada vez más la región donde ésta se encuentra. La ventaja sobre los métodos clásicos de distancia consiste en una única estimación del sitio de falla para sistemas ramificados. Un ejemplo de aplicación con el modelo de un sistema real muestra que la metodología propuesta es altamente efectiva para resolver el problema, donde se consideran variaciones de carga de ±40 % de la carga nominal.

Peripheral blood TIM-3 positive NK and CD8+ T cells throughout pregnancy

DEFF Research Database (Denmark)

Meggyes, Matyas; Miko, Eva; Polgar, Beata

2014-01-01

PROBLEM: The T-cell immunoglobulin and mucin domain (TIM) family is a relatively newly described group of molecules with a conserved structure and important immunological functions. Identification of Galectin-9 as a ligand for TIM-3 has established the Galectin-9/TIM-3 pathway as an important...... negative regulator of Th1 immunity and tolerance induction. Data about the TIM-3/Gal-9 pathway in the pathogenesis of human diseases is emerging, but their possible role during human pregnancy is not precisely known. The aim of our study was to investigate the number, phenotype and functional activity...... of TIM-3+ peripheral blood mononuclear cells during healthy human pregnancy. METHODS OF STUDY: 57 healthy pregnant women [first trimester (n = 16); second trimester (n = 19); third trimester (n = 22)] and 30 non-pregnant controls were enrolled in the study. We measured the surface expression of TIM-3...

Mecanismo de falla de los tubos del sobrecalentador de una caldera acuotubular

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John Jairo Coronado Marín

2007-09-01

Full Text Available En este artículo se investigaron las causas de las fallas presentadas por fisuración longitudinal a partir de la superficie externa en los tubos del sobrecalentador de una caldera acuotubular. La superficie externa de los tubos presentó una capa de color blanco-rojizo que presentó cadenas parafínicas: C-H, grupos funcionales: C-O, N-H y compuestos de azufre, esta capa frágil impide la transferencia de calor, causando un aumento de temperatura del tubo. La falla se presentó por termofluencia debido al sobrecalentamiento de larga duración, la microestructura del tubo de acero en el lado externo presentó: crecimiento de grano, globulización de la cemen-tita y fisuras intergranulares que producen pérdidas de las propiedades mecánicas del acero. Las observaciones anteriores evidencian un deterioro de la microestructura facilitado por un material que no está en capacidad de operar usando exclusivamente bagazo como combustible.

Clasificación y detección de fallas en Sistemas Dinámicos

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Javier Hernando Pardo Mayorga

2006-05-01

Full Text Available En los sistemas dinámicos se pueden presentar fallas en cualquier instante de tiempo, estas fallas pueden ser generadas en gran cantidad de casos por la variación de uno o más parámetros de la planta o del sistema dinámico. En este trabajo se propone la detección de fallas en una planta no lineal de dos tanques acoplados uno con área constante y otro variable con la altura esto basado en observadores adaptivos, sustentado con clasificación LAMDA y análisis de componentes principales. Se presenta la aplicación del algoritmo en un sistema no lineal, control del nivel en un sistema de tanques acoplados, así como el análisis de resultados conclusiones y perspectivas futuras./ In the dynamic systems a fail can occur in any moment, the fail can be present for variations in one or more parameter of the dynamic system. This paper present a fail detection in a non linear system compose by two tanks in parallel one with constant transversal area and the other one with variable area, the work is develop with adaptive observers and LAMDA classification. The application on this paper is in a non linear system, the level control in the two tank system.

Falla Moa: caracterización geodinámica y riesgos tectónicos asociados

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José A. Batista-Rodríguez

2007-03-01

Full Text Available En el contexto geodinámico del noreste oriental de Cuba existen numerosas estructuras disyuntivas activas que se ponen de manifiesto a través de los movimientos lentos y pulsantes, y de la actividad sísmica. Dentro de esas estructuras se encuentra la Falla Moa, que se extiende de forma submeridional, cortando el macizo ofiolítico y atravesando importantes yacimientos e instalaciones de la localidad. La caracterización de esta falla partiendo de su génesis, sentido de desplazamiento de los bloques rocosos y elementos que facilitaron su interpretación y cartografiado son tratados en este artículo, donde además se propone la necesidad del monitoreo de dicha estructura a partir de la influencia de ella en el medio ambiente territorial.

A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9

International Nuclear Information System (INIS)

Weyer, Philipp S. van de; Muehlfeit, Michael; Klose, Christoph; Bonventre, Joseph V.; Walz, Gerd; Kuehn, E. Wolfgang

2006-01-01

Tim-3 is a member of the TIM family of proteins (T-cell immunoglobulin mucin) involved in the regulation of CD4+ T-cells. Tim-3 is a T H 1-specific type 1 membrane protein and regulates T H 1 proliferation and the development of tolerance. Binding of galectin-9 to the extracellular domain of Tim-3 results in apoptosis of T H 1 cells, but the intracellular pathways involved in the regulatory function of Tim-3 are unknown. Unlike Tim-1, which is expressed in renal epithelia and cancer, Tim-3 has not been described in cells other than neuronal or T-cells. Using RT-PCR we demonstrate that Tim-3 is expressed in malignant and non-malignant epithelial tissues. We have cloned Tim-3 from an immortalized liver cell carcinoma line and identified a highly conserved tyrosine in the intracellular tail of Tim-3 (Y265). We demonstrate that Y265 is specifically phosphorylated in vivo by the interleukin inducible T cell kinase (ITK), a kinase which is located in close proximity of the TIM genes on the allergy susceptibility locus 5q33.3. Stimulation of Tim-3 by its ligand galectin-9 results in increased phosphorylation of Y265, suggesting that this tyrosine residue plays an important role in downstream signalling events regulating T-cell fate. Given the role of TIM proteins in autoimmunity and cancer, the conserved SH2 binding domain surrounding Y265 could represent a possible target site for pharmacological intervention

The TIM Barrel Architecture Facilitated the Early Evolution of Protein-Mediated Metabolism.

Science.gov (United States)

Goldman, Aaron David; Beatty, Joshua T; Landweber, Laura F

2016-01-01

The triosephosphate isomerase (TIM) barrel protein fold is a structurally repetitive architecture that is present in approximately 10% of all enzymes. It is generally assumed that this ubiquity in modern proteomes reflects an essential historical role in early protein-mediated metabolism. Here, we provide quantitative and comparative analyses to support several hypotheses about the early importance of the TIM barrel architecture. An information theoretical analysis of protein structures supports the hypothesis that the TIM barrel architecture could arise more easily by duplication and recombination compared to other mixed α/β structures. We show that TIM barrel enzymes corresponding to the most taxonomically broad superfamilies also have the broadest range of functions, often aided by metal and nucleotide-derived cofactors that are thought to reflect an earlier stage of metabolic evolution. By comparison to other putatively ancient protein architectures, we find that the functional diversity of TIM barrel proteins cannot be explained simply by their antiquity. Instead, the breadth of TIM barrel functions can be explained, in part, by the incorporation of a broad range of cofactors, a trend that does not appear to be shared by proteins in general. These results support the hypothesis that the simple and functionally general TIM barrel architecture may have arisen early in the evolution of protein biosynthesis and provided an ideal scaffold to facilitate the metabolic transition from ribozymes, peptides, and geochemical catalysts to modern protein enzymes.

Diseño y construcción de un prototipo digital para diagnósticar fallas en motores de inducción

Directory of Open Access Journals (Sweden)

FERNANDO VILLADA DUQUE

2007-01-01

Full Text Available En este trabajo se presenta el desarrollo de un prototipo digital utilizando un procesador de señales digitales DSP, al cual se le han incorporado dos algoritmos para diagnosticar fallas en el estator de motores de inducción. El primer algoritmo utiliza las redes neuronales artificiales para estimar la corriente de secuencia negativa, la cual es utilizada como indicador de falla. El segundo algoritmo utiliza la impedancia de secuencia inversa como indicador de falla. Se presenta la estructura general del prototipo y su implementación. Se incluyen los resultados obtenidos experimentalmente en un motor de 3 HP utilizando medida en línea a través del prototipo digital

Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria.

Science.gov (United States)

Mokranjac, Dejana; Sichting, Martin; Popov-Celeketić, Dusan; Mapa, Koyeli; Gevorkyan-Airapetov, Lada; Zohary, Keren; Hell, Kai; Azem, Abdussalam; Neupert, Walter

2009-03-01

Transport of essentially all matrix and a number of inner membrane proteins is governed, entirely or in part, by N-terminal presequences and requires a coordinated action of the translocases of outer and inner mitochondrial membranes (TOM and TIM23 complexes). Here, we have analyzed Tim50, a subunit of the TIM23 complex that is implicated in transfer of precursors from TOM to TIM23. Tim50 is recruited to the TIM23 complex via Tim23 in an interaction that is essentially independent of the rest of the translocase. We find Tim50 in close proximity to the intermembrane space side of the TOM complex where it recognizes both types of TIM23 substrates, those that are to be transported into the matrix and those destined to the inner membrane, suggesting that Tim50 recognizes presequences. This function of Tim50 depends on its association with TIM23. We conclude that the efficient transfer of precursors between TOM and TIM23 complexes requires the concerted action of Tim50 with Tim23.

Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm.

Science.gov (United States)

Younan, Patrick; Iampietro, Mathieu; Nishida, Andrew; Ramanathan, Palaniappan; Santos, Rodrigo I; Dutta, Mukta; Lubaki, Ndongala Michel; Koup, Richard A; Katze, Michael G; Bukreyev, Alexander

2017-09-26

Ebola virus (EBOV) disease (EVD) results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a "cytokine storm." Previous reports have suggested that nonspecific activation of T lymphocytes may play a central role in this phenomenon. T-cell immunoglobulin and mucin domain-containing protein 1 (Tim-1) has recently been shown to interact with virion-associated phosphatidylserine to promote infection. Here, we demonstrate the central role of Tim-1 in EBOV pathogenesis, as Tim-1 -/- mice exhibited increased survival rates and reduced disease severity; surprisingly, only a limited decrease in viremia was detected. Tim-1 -/- mice exhibited a modified inflammatory response as evidenced by changes in serum cytokines and activation of T helper subsets. A series of in vitro assays based on the Tim-1 expression profile on T cells demonstrated that despite the apparent absence of detectable viral replication in T lymphocytes, EBOV directly binds to isolated T lymphocytes in a phosphatidylserine-Tim-1-dependent manner. Exposure to EBOV resulted in the rapid development of a CD4 Hi CD3 Low population, non-antigen-specific activation, and cytokine production. Transcriptome and Western blot analysis of EBOV-stimulated CD4 + T cells confirmed the induction of the Tim-1 signaling pathway. Furthermore, comparative analysis of transcriptome data and cytokine/chemokine analysis of supernatants highlight the similarities associated with EBOV-stimulated T cells and the onset of a cytokine storm. Flow cytometry revealed virtually exclusive binding and activation of central memory CD4 + T cells. These findings provide evidence for the role of Tim-1 in the induction of a cytokine storm phenomenon and the pathogenesis of EVD. IMPORTANCE Ebola virus infection is characterized by a massive release of inflammatory mediators, which has come to be known as a cytokine storm. The severity of the cytokine storm is

[Lea Kõiv. Paul Johansen und das Stadtarchiv Reval/Tallinn] / Paul Kaegbein

Index Scriptorium Estoniae

Kaegbein, Paul

2008-01-01

Arvustus: Lea Kõiv. Paul Johansen und das Stadtarchiv Reval/Tallinn. - Nordosteuropa als Geschichtsregion. Helsinki : Aue-Stiftung; Lübeck : Schmict-Röhmild, 2006. Lk. 45-59. Artiklis on kasutatud seni avalikkusele vähetuntud materjale ja osaliselt käsitletud avalikke vaidlusi, kuhu olid segatud nii Paul Johansen kui järgmine linnaarhivaar Rudolf Kenkmaa

DISEÑO DE UNA HERRAMIENTA EFICIENTE DE SIMULACIÓN AUTOMÁTICA DE FALLAS EN SISTEMAS ELÉCTRICOS DE POTENCIA

Directory of Open Access Journals (Sweden)

LUCAS PÉREZ-HERNÁNDEZ

2010-01-01

Full Text Available En este artículo se propone una alternativa eficiente para la simulación automática de fallas en sistemas de potencia a partir de una estrategia cooperativa entre Matlab â y el ATP. Esta estrategia de simulación permite reducir el tiempo para la obtención de una base de datos de fallas, tal como lo demuestran los resultados comparativos obtenidos en el caso de cuatro sistemas diferentes, donde se obtuvieron reducciones promedio del 96% en el tiempo de simulación, con respecto al tiempo de simulación obtenido con las metodologías clásicas. Las bases de datos obtenidas a partir de las simulaciones son normalmente utilizadas para ajustar herramientas de computación suave aplicadas a la resolución de problemas, tal como el aquí referenciado y asociado a la localización de fallas en sistemas de distribución de energía eléctrica.

TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action

Directory of Open Access Journals (Sweden)

Wenwen Du

2017-03-01

Full Text Available Cancer immunotherapy has produced impressive clinical results in recent years. Despite the success of the checkpoint blockade strategies targeting cytotoxic T lymphocyte antigen 4 (CTLA-4 and programmed death receptor 1 (PD-1, a large portion of cancer patients have not yet benefited from this novel therapy. T cell immunoglobulin and mucin domain 3 (TIM-3 has been shown to mediate immune tolerance in mouse models of infectious diseases, alloimmunity, autoimmunity, and tumor Immunity. Thus, targeting TIM-3 emerges as a promising approach for further improvement of current immunotherapy. Despite a large amount of experimental data showing an immune suppressive function of TIM-3 in vivo, the exact mechanisms are not well understood. To enable effective targeting of TIM-3 for tumor immunotherapy, further in-depth mechanistic studies are warranted. These studies will also provide much-needed insight for the rational design of novel combination therapy with other checkpoint blockers. In this review, we summarize key evidence supporting an immune regulatory role of TIM-3 and discuss possible mechanisms of action.

Karjas on ohutum elada / Toomas Paul

Index Scriptorium Estoniae

Paul, Toomas, 1939-

2003-01-01

Vt. ka Paul, Toomas. "Löö esimesena, Freddy!". Eesti Päevaleht, 8. mai 2003. Inimesest kui karjaloomast, inimloomusest ja sallivusest. Ilm. ka: Paul, Toomas. Ole salliv, Bob // Pastishsh & popurrii : ilmavaatlusi / Paul, Toomas. - [Tallinn] : Oomen, 2007. - Lk. 54-58

Diseño de un Sistema de Detección y Diagnóstico de Fallas basado en Modelo para una Planta Desalinizadora de Agua de Mar

OpenAIRE

Soto Angles, Mario Eduardo

2016-01-01

Los sistemas de diagnóstico de fallas cumplen un papel importante en los sistemas de control en la actualidad, ya que los distintos elementos que componen la planta son susceptibles a fallas. Las fallas que ocurren en una planta desalinizadora por ósmosis inversa pueden traer como consecuencia una mala calidad de agua desalinizada, reducir considerablemente la eficiencia de producción de la planta, poner en peligro la integridad de los operadores de la planta o provocar problem...

Validación de señales vibro-acústicas para el diagnóstico de fallas en rodamientos en un generador síncrono

OpenAIRE

Zulma Yadira Medrano Hurtado; Carlos Pérez Tello

2017-01-01

En este trabajo se describe el procedimiento y las herramientas utilizados en la medición y diagnóstico de señales de vibración capturadas a través de transductores de aceleración (acelerómetros piezoeléctricos) y acústicos (micrófonos omnidireccionales). Además, se desarrolló un arreglo experimental empleando la metodología Taguchi para validar la información registrada de las señales de vibración para rodamientos sin falla y con falla artificial, respectivamente. La falla artificial consist...

Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm

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Patrick Younan

2017-09-01

Full Text Available Ebola virus (EBOV disease (EVD results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a “cytokine storm.” Previous reports have suggested that nonspecific activation of T lymphocytes may play a central role in this phenomenon. T-cell immunoglobulin and mucin domain-containing protein 1 (Tim-1 has recently been shown to interact with virion-associated phosphatidylserine to promote infection. Here, we demonstrate the central role of Tim-1 in EBOV pathogenesis, as Tim-1−/− mice exhibited increased survival rates and reduced disease severity; surprisingly, only a limited decrease in viremia was detected. Tim-1−/− mice exhibited a modified inflammatory response as evidenced by changes in serum cytokines and activation of T helper subsets. A series of in vitro assays based on the Tim-1 expression profile on T cells demonstrated that despite the apparent absence of detectable viral replication in T lymphocytes, EBOV directly binds to isolated T lymphocytes in a phosphatidylserine–Tim-1-dependent manner. Exposure to EBOV resulted in the rapid development of a CD4Hi CD3Low population, non-antigen-specific activation, and cytokine production. Transcriptome and Western blot analysis of EBOV-stimulated CD4+ T cells confirmed the induction of the Tim-1 signaling pathway. Furthermore, comparative analysis of transcriptome data and cytokine/chemokine analysis of supernatants highlight the similarities associated with EBOV-stimulated T cells and the onset of a cytokine storm. Flow cytometry revealed virtually exclusive binding and activation of central memory CD4+ T cells. These findings provide evidence for the role of Tim-1 in the induction of a cytokine storm phenomenon and the pathogenesis of EVD.

Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus.

Science.gov (United States)

Jang, A Reum; Moravcevic, Katarina; Saez, Lino; Young, Michael W; Sehgal, Amita

2015-02-01

Regulated nuclear entry of clock proteins is a conserved feature of eukaryotic circadian clocks and serves to separate the phase of mRNA activation from mRNA repression in the molecular feedback loop. In Drosophila, nuclear entry of the clock proteins, PERIOD (PER) and TIMELESS (TIM), is tightly controlled, and impairments of this process produce profound behavioral phenotypes. We report here that nuclear entry of PER-TIM in clock cells, and consequently behavioral rhythms, require a specific member of a classic nuclear import pathway, Importin α1 (IMPα1). In addition to IMPα1, rhythmic behavior and nuclear expression of PER-TIM require a specific nuclear pore protein, Nup153, and Ran-GTPase. IMPα1 can also drive rapid and efficient nuclear expression of TIM and PER in cultured cells, although the effect on PER is mediated by TIM. Mapping of interaction domains between IMPα1 and TIM/PER suggests that TIM is the primary cargo for the importin machinery. This is supported by attenuated interaction of IMPα1 with TIM carrying a mutation previously shown to prevent nuclear entry of TIM and PER. TIM is detected at the nuclear envelope, and computational modeling suggests that it contains HEAT-ARM repeats typically found in karyopherins, consistent with its role as a co-transporter for PER. These findings suggest that although PER is the major timekeeper of the clock, TIM is the primary target of nuclear import mechanisms. Thus, the circadian clock uses specific components of the importin pathway with a novel twist in that TIM serves a karyopherin-like role for PER.

Validación de señales vibro-acústicas para el diagnóstico de fallas en rodamientos en un generador síncrono

Directory of Open Access Journals (Sweden)

Zulma Yadira Medrano Hurtado

2017-01-01

Full Text Available En este trabajo se describe el procedimiento y las herramientas utilizados en la medición y diagnóstico de señales de vibración capturadas a través de transductores de aceleración (acelerómetros piezoeléctricos y acústicos (micrófonos omnidireccionales. Además, se desarrolló un arreglo experimental empleando la metodología Taguchi para validar la información registrada de las señales de vibración para rodamientos sin falla y con falla artificial, respectivamente. La falla artificial consistió en una grieta producida en la jaula de un rodamiento SKF-6303-2RSH.Este método es no invasivo, ya que utiliza micrófonos para analizar la vibración, lo que representa no tener que montar ningún tipo de transductor en la máquina, además de ser sensible a fallas en la jaula.

Awards: New Year Knighthood for Tim Berners-Lee

CERN Multimedia

2004-01-01

Tim Berners-Lee has been awarded his country's highest honour - a knighthood - in the UK's New Year Honours list for his work while at CERN on the World Wide Web. In the same honours list, Roger Cashmore has been made a Companion of the Order of St Michael and St George (CMG) "for his services to international co-operation in particle physics". Cashmore was CERN's Director for Collider Programmes from 1999-2003, and is now Principal of Brasenose College, Oxford. Tim Berners-Lee stands in front of the first web server at Palexpo during the World Summit on the Information Society.

Tim Berners-Lee at the RSIS conference from 8-9 December 2003.

CERN Multimedia

Patrice Loiez

2003-01-01

Tim Berners-Lee participated in the Role of Science in the Information Society conference held at CERN from 8-9 December 2003. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

Diálisis peritoneal paliativa en pacientes con falla cardiaca sin enfermedad renal terminal

Directory of Open Access Journals (Sweden)

María J. Rodríguez-González

2017-03-01

Se ha realizado una revisión de este escenario específico con presentación de los primeros casos que se han dispuesto con esta finalidad en la clínica de falla cardíaca de la Fundación Cardiovascular de Colombia.

TIM, a ray-tracing program for METATOY research and its dissemination

Science.gov (United States)

Lambert, Dean; Hamilton, Alasdair C.; Constable, George; Snehanshu, Harsh; Talati, Sharvil; Courtial, Johannes

2012-03-01

TIM (The Interactive METATOY) is a ray-tracing program specifically tailored towards our research in METATOYs, which are optical components that appear to be able to create wave-optically forbidden light-ray fields. For this reason, TIM possesses features not found in other ray-tracing programs. TIM can either be used interactively or by modifying the openly available source code; in both cases, it can easily be run as an applet embedded in a web page. Here we describe the basic structure of TIM's source code and how to extend it, and we give examples of how we have used TIM in our own research. Program summaryProgram title: TIM Catalogue identifier: AEKY_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEKY_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU General Public License No. of lines in distributed program, including test data, etc.: 124 478 No. of bytes in distributed program, including test data, etc.: 4 120 052 Distribution format: tar.gz Programming language: Java Computer: Any computer capable of running the Java Virtual Machine (JVM) 1.6 Operating system: Any; developed under Mac OS X Version 10.6 RAM: Typically 145 MB (interactive version running under Mac OS X Version 10.6) Classification: 14, 18 External routines: JAMA [1] (source code included) Nature of problem: Visualisation of scenes that include scene objects that create wave-optically forbidden light-ray fields. Solution method: Ray tracing. Unusual features: Specifically designed to visualise wave-optically forbidden light-ray fields; can visualise ray trajectories; can visualise geometric optic transformations; can create anaglyphs (for viewing with coloured "3D glasses") and random-dot autostereograms of the scene; integrable into web pages. Running time: Problem-dependent; typically seconds for a simple scene.

Clasificación de fallas en motores eléctricos utilizando señales de vibración

OpenAIRE

Arango Flórez, Gustavo Adolfo

2007-01-01

La tesis está encaminada a la aplicación de las técnicas tiempo frecuencia al análisis de senales de vibración para el diagnóstico de fallas en máquinas rotativas. Para esto se implementan métodos de extracción y clasificación de caracteristicas para lograr acercar de manera más precisa al diagnosticador a encontrar la causa raíz de la falla. Se realiza un estudio de cuatro métodos de extracción de características: Transformadas Wavelet, Distribución Wigner Ville, Distribución Choi Williams y...

Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4.

Science.gov (United States)

Tietjen, Gregory T; Gong, Zhiliang; Chen, Chiu-Hao; Vargas, Ernesto; Crooks, James E; Cao, Kathleen D; Heffern, Charles T R; Henderson, J Michael; Meron, Mati; Lin, Binhua; Roux, Benot; Schlossman, Mark L; Steck, Theodore L; Lee, Ka Yee C; Adams, Erin J

2014-04-15

Recognition of phosphatidylserine (PS) lipids exposed on the extracellular leaflet of plasma membranes is implicated in both apoptotic cell removal and immune regulation. The PS receptor T cell immunoglobulin and mucin-domain-containing molecule 4 (Tim4) regulates T-cell immunity via phagocytosis of both apoptotic (high PS exposure) and nonapoptotic (intermediate PS exposure) activated T cells. The latter population must be removed at lower efficiency to sensitively control immune tolerance and memory cell population size, but the molecular basis for how Tim4 achieves this sensitivity is unknown. Using a combination of interfacial X-ray scattering, molecular dynamics simulations, and membrane binding assays, we demonstrate how Tim4 recognizes PS in the context of a lipid bilayer. Our data reveal that in addition to the known Ca(2+)-coordinated, single-PS binding pocket, Tim4 has four weaker sites of potential ionic interactions with PS lipids. This organization makes Tim4 sensitive to PS surface concentration in a manner capable of supporting differential recognition on the basis of PS exposure level. The structurally homologous, but functionally distinct, Tim1 and Tim3 are significantly less sensitive to PS surface density, likely reflecting the differences in immunological function between the Tim proteins. These results establish the potential for lipid membrane parameters, such as PS surface density, to play a critical role in facilitating selective recognition of PS-exposing cells. Furthermore, our multidisciplinary approach overcomes the difficulties associated with characterizing dynamic protein/membrane systems to reveal the molecular mechanisms underlying Tim4's recognition properties, and thereby provides an approach capable of providing atomic-level detail to uncover the nuances of protein/membrane interactions.

Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3).

Science.gov (United States)

Homayouni, Vida; Ganjalikhani-Hakemi, Mazdak; Rezaei, Abbas; Khanahmad, Hossein; Behdani, Mahdi; Lomedasht, Fatemeh Kazemi

2016-11-01

As T-cell immunoglobulin and mucin domain 3 (TIM-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. Based on the unique features of nanobodies, we aimed to construct an anti-TIM-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. We immunized a camel with TIM-3 antigen and then, synthesized a VHH phage: mid library from its B cell's transcriptome using nested PCR. Library selection against TIM-3antigen was performed in three rounds of panning. Using phage-ELISA, the most reactive colonies were selected for sub-cloning in soluble protein expression vectors. The Nanobody was purified and confirmed with a nickel-nitrilotriacetic acid (Ni-NTA) column, SDS-PAGE and Western blotting. A flowcytometric analysis was performed to analyze the binding and biologic activities of theTIM-3 specific nanobody with TIM-3 expressing HL-60 and HEK cell lines. Specific 15kD band representing for nanobody was observed on the gel and confirmed with Western blotting. The nanobody showed significant specific immune-reactivity against TIM-3 with a relatively high binding affinity. The nanobody significantly suppressed the proliferation of TIM-3 expressing HL-60 cell line. Finally, we successfully prepared a functional anti-humanTIM-3 specific nanobody with a high affinity and an anti-proliferative activity on an AML cell line in vitro.

Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3

Directory of Open Access Journals (Sweden)

Vida Homayouni

2016-11-01

Full Text Available Objective(s: As T-cell immunoglobulin and mucin domain 3 (TIM-3 is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. Based on the unique features of nanobodies, we aimed to construct an anti-TIM-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. Materials and Methods:We immunized a camel with TIM-3 antigen and then, synthesized a VHH phagemid library from its B cell’s transcriptome using nested PCR. Library selection against TIM-3antigen was performed in three rounds of panning. Using phage-ELISA, the most reactive colonies were selected for sub-cloning in soluble protein expression vectors. The Nanobody was purified and confirmed with a nickel-nitrilotriacetic acid (Ni-NTA column, SDS-PAGE and Western blotting. A flowcytometric analysis was performed to analyze the binding and biologic activities of theTIM-3 specific nanobody with TIM-3 expressing HL-60 and HEK cell lines. Results:Specific 15kD band representing for nanobody was observed on the gel and confirmed with Western blotting. The nanobody showed significant specific immune-reactivity against TIM-3 with a relatively high binding affinity. The nanobody significantly suppressed the proliferation of TIM-3 expressing HL-60 cell line. Conclusion: Finally, we successfully prepared a functional anti-humanTIM-3 specific nanobody with a high affinity and an anti-proliferative activity on an AML cell line in vitro.

A polymorphism of the TIM-1 IgV domain: implications for the susceptibility to filovirus infection.

Science.gov (United States)

Kuroda, Makoto; Fujikura, Daisuke; Noyori, Osamu; Kajihara, Masahiro; Maruyama, Junki; Miyamoto, Hiroko; Yoshida, Reiko; Takada, Ayato

2014-12-12

Filoviruses, including Ebola and Marburg viruses, cause severe hemorrhagic fever in humans and nonhuman primates with mortality rates of up to 90%. Human T-cell immunoglobulin and mucin domain 1 (TIM-1) is one of the host proteins that have been shown to promote filovirus entry into cells. In this study, we cloned TIM-1 genes from three different African green monkey kidney cell lines (Vero E6, COS-1, and BSC-1) and found that TIM-1 of Vero E6 had a 23-amino acid deletion and 6 amino acid substitutions compared with those of COS-1 and BSC-1. Interestingly, Vero E6 TIM-1 had a greater ability to promote the infectivity of vesicular stomatitis viruses pseudotyped with filovirus glycoproteins than COS-1-derived TIM-1. We further found that the increased ability of Vero E6 TIM-1 to promote virus infectivity was most likely due to a single amino acid difference between these TIM-1s. These results suggest that a polymorphism of the TIM-1 molecules is one of the factors that influence cell susceptibility to filovirus infection, providing a new insight into the molecular basis for the filovirus host range. Copyright © 2014 Elsevier Inc. All rights reserved.

Airborne Thermal Infrared Multispectral Scanner (TIMS) images over disseminated gold deposits, Osgood Mountains, Humboldt County, Nevada

Science.gov (United States)

Krohn, M. Dennis

1986-01-01

The U.S. Geological Survey (USGS) acquired airborne Thermal Infrared Multispectral Scanner (TIMS) images over several disseminated gold deposits in northern Nevada in 1983. The aerial surveys were flown to determine whether TIMS data could depict jasperoids (siliceous replacement bodies) associated with the gold deposits. The TIMS data were collected over the Pinson and Getchell Mines in the Osgood Mountains, the Carlin, Maggie Creek, Bootstrap, and other mines in the Tuscarora Mountains, and the Jerritt Canyon Mine in the Independence Mountains. The TIMS data seem to be a useful supplement to conventional geochemical exploration for disseminated gold deposits in the western United States. Siliceous outcrops are readily separable in the TIMS image from other types of host rocks. Different forms of silicification are not readily separable, yet, due to limitations of spatial resolution and spectral dynamic range. Features associated with the disseminated gold deposits, such as the large intrusive bodies and fault structures, are also resolvable on TIMS data. Inclusion of high-resolution thermal inertia data would be a useful supplement to the TIMS data.

Traditional Indian medicine (TIM) and traditional Korean medicine (TKM): aconstitutional-based concept and comparison.

Science.gov (United States)

Kang, Young Min; Komakech, Richard; Karigar, Chandrakant Shivappa; Saqib, Asma

2017-06-01

Traditional and complementary medicine (T&CM) plays an integral role in providing health care worldwide. It is based on sound fundamental principles and centuries of practices. This study compared traditional Indian medicine (TIM) and traditional Korean medicine (TKM) basing on data obtained from peer reviewed articles, respective government institutional reports and World Health Organization reports. Despite the fact that TIM and TKM have individual qualities that are unique from each other including different histories of origin, they share a lot in common. Apart from Homeopathy in TIM, both systems are hinged on similar principle of body constitutional-based concept and similar disease diagnosis methods of mainly auscultation, palpation, visual inspection, and interrogation. Similarly, the treatment methods of TIM and TKM follow similar patterns involving use of medicinal herbs, moxibustion, acupuncture, cupping, and manual therapy. Both T&CM are majorly practiced in well-established hospitals by T&CM doctors who have undergone an average of 6-7 years of specialized trainings. However, unlike TIM which has less insurance coverage, the popularity of TKM is majorly due to its wide national insurance coverage. These two medical traditions occupy increasingly greater portion of the global market. However, TIM especially Ayurveda has gained more global recognition than TKM although the emergence of Sasang Constitutional Medicine in TKM is beginning to become more popular. This comparative analysis between TIM and TKM may provide vital and insightful contribution towards constitutional-based concept for further development and future studies in T&CM.

Meet EPA Scientist Tim Shafer, Ph.D.

Science.gov (United States)

Tim Shafer earned his bachelor’s degree in biology and chemistry from Hope College in Holland, MI, in 1986 and his Ph.D. in pharmacology and environmental toxicology from Michigan State University in 1991.

Downregulation of TIM-3 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

Energy Technology Data Exchange (ETDEWEB)

Cai, X.Z. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang (China); Huang, W.Y.; Qiao, Y.; Chen, Y.; Du, S.Y.; Chen, D.; Yu, S. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Liu, N. [Department of Nephrology, First Affiliated Hospital, China Medical University, Shenyang (China); Dou, L.Y. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Jiang, Y. [Central Laboratory, First Affiliated Hospital, China Medical University, Shenyang (China); Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang (China); Department of Dermatology, First Affiliated Hospital, China Medical University, Shenyang (China)

2014-10-17

The T-cell immunoglobulin and mucin domain (TIM) family is associated with autoimmune diseases, but its expression level in the immune cells of systemic lupus erythematosus (SLE) patients is not known. The aim of this study was to investigate whether the expression of TIM-3 mRNA is associated with pathogenesis of SLE. Quantitative real-time reverse transcription-polymerase chain reaction analysis (qRT-PCR) was used to determine TIM-1, TIM-3, and TIM-4 mRNA expression in peripheral blood mononuclear cells (PBMCs) from 132 patients with SLE and 62 healthy controls. The PBMC surface protein expression of TIMs in PBMCs from 20 SLE patients and 15 healthy controls was assayed by flow cytometry. Only TIM-3 mRNA expression decreased significantly in SLE patients compared with healthy controls (P<0.001). No significant differences in TIM family protein expression were observed in leukocytes from SLE patients and healthy controls (P>0.05). SLE patients with lupus nephritis (LN) had a significantly lower expression of TIM-3 mRNA than those without LN (P=0.001). There was no significant difference in the expression of TIM-3 mRNA within different classes of LN (P>0.05). Correlation of TIM-3 mRNA expression with serum IgA was highly significant (r=0.425, P=0.004), but was weakly correlated with total serum protein (r{sub s}=0.283, P=0.049) and serum albumin (r{sub s}=0.297, P=0.047). TIM-3 mRNA expression was weakly correlated with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI; r{sub s}=-0.272, P=0.032). Our results suggest that below-normal expression of TIM-3 mRNA in PBMC may be involved in the pathogenesis of SLE.

Downregulation of TIM-3 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

International Nuclear Information System (INIS)

Cai, X.Z.; Huang, W.Y.; Qiao, Y.; Chen, Y.; Du, S.Y.; Chen, D.; Yu, S.; Liu, N.; Dou, L.Y.; Jiang, Y.

2014-01-01

The T-cell immunoglobulin and mucin domain (TIM) family is associated with autoimmune diseases, but its expression level in the immune cells of systemic lupus erythematosus (SLE) patients is not known. The aim of this study was to investigate whether the expression of TIM-3 mRNA is associated with pathogenesis of SLE. Quantitative real-time reverse transcription-polymerase chain reaction analysis (qRT-PCR) was used to determine TIM-1, TIM-3, and TIM-4 mRNA expression in peripheral blood mononuclear cells (PBMCs) from 132 patients with SLE and 62 healthy controls. The PBMC surface protein expression of TIMs in PBMCs from 20 SLE patients and 15 healthy controls was assayed by flow cytometry. Only TIM-3 mRNA expression decreased significantly in SLE patients compared with healthy controls (P<0.001). No significant differences in TIM family protein expression were observed in leukocytes from SLE patients and healthy controls (P>0.05). SLE patients with lupus nephritis (LN) had a significantly lower expression of TIM-3 mRNA than those without LN (P=0.001). There was no significant difference in the expression of TIM-3 mRNA within different classes of LN (P>0.05). Correlation of TIM-3 mRNA expression with serum IgA was highly significant (r=0.425, P=0.004), but was weakly correlated with total serum protein (r s =0.283, P=0.049) and serum albumin (r s =0.297, P=0.047). TIM-3 mRNA expression was weakly correlated with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI; r s =-0.272, P=0.032). Our results suggest that below-normal expression of TIM-3 mRNA in PBMC may be involved in the pathogenesis of SLE

Efectividad de la utilización de métodos microtectónicos en el desciframiento de la evoluación de estructuras tectónicas (falla Pinar

Directory of Open Access Journals (Sweden)

Dámaso Cáceres-Govea

2003-03-01

Full Text Available Se analiza el comportamiento de la falla Pinar a partir de datos reales de varios afloramientos descritos a lo largo de dicha estructura. El uso de la microtectónica y el análisis estructural permitió detectar e interpretar algunos indicadores cinématicos que denotan su funcionamiento transcurrente siniestro en su etapa inicial. Asimismo, estructuras superpuestas en diferentes planos de falla permitieron detectar desplazamientos subhorizontales que marcan una etapa intermedia de transición, para culminar su evolución como una clásica falla gravitacional.

Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice.

Science.gov (United States)

Du, Xianhong; Wu, Zhuanchang; Xu, Yong; Liu, Yuan; Liu, Wen; Wang, Tixiao; Li, Chunyang; Zhang, Cuijuan; Yi, Fan; Gao, Lifen; Liang, Xiaohong; Ma, Chunhong

2018-05-07

As an immune checkpoint, Tim-3 plays roles in the regulation of both adaptive and innate immune cells including macrophages and is greatly involved in chronic liver diseases. However, the precise roles of Tim-3 in nonalcoholic steatohepatitis (NASH) remain unstated. In the current study, we analyzed Tim-3 expression on different subpopulations of liver macrophages and further investigated the potential roles of Tim-3 on hepatic macrophages in methionine and choline-deficient diet (MCD)-induced NASH mice. The results of flow cytometry demonstrated the significantly increased expression of Tim-3 on all detected liver macrophage subsets in MCD mice, including F4/80 + CD11b + , F4/80 + CD68 + , and F4/80 + CD169 + macrophages. Remarkably, Tim-3 knockout (KO) significantly accelerated MCD-induced liver steatosis, displaying higher serum ALT, larger hepatic vacuolation, more liver lipid deposition, and more severe liver fibrosis. Moreover, compared with wild-type C57BL/6 mice, Tim-3 KO MCD mice demonstrated an enhanced expression of NOX2, NLRP3, and caspase-1 p20 together with increased generation of IL-1β and IL-18 in livers. In vitro studies demonstrated that Tim-3 negatively regulated the production of reactive oxygen species (ROS) and related downstream pro-inflammatory cytokine secretion of IL-1β and IL-18 in macrophages. Exogenous administration of N-Acetyl-L-cysteine (NAC), a small molecular inhibitor of ROS, remarkably suppressed caspase-1 p20 expression and IL-1β and IL-18 production in livers of Tim-3 KO mice, thus significantly reducing the severity of steatohepatitis induced by MCD. In conclusion, Tim-3 is a promising protector in MCD-induced steatohepatitis by controlling ROS and the associated pro-inflammatory cytokine production in macrophages.

APPLICATIONS OF WAVELETS IN INDUCTION MACHINE FAULT DETECTION APLICACIONES DE WAVELETS EN LA DETECCIÓN DE FALLAS DE MÁQUINAS DE INDUCCIÓN

Directory of Open Access Journals (Sweden)

Erick Schmitt

2010-08-01

Full Text Available This paper presents a new wavelet-based algorithm for three-phase induction machine fault detection. This new method uses the standard deviation of wavelet coefficients, obtained from n-level decomposition of each phase voltage and current, to identify single-phasing faults or unbalanced stator resistance faults in induction machines. The proposed algorithm can operate independent of the operational frequency, fault type and loading conditions. Results show that this algorithm has better detection response than the Fourier transform-based techniques.Este trabajo presenta un nuevo algoritmo basado en wavelets para la detección de fallas en máquinas de inducción de tres fases. Este nuevo método utiliza la desviación estándar de los coeficientes wavelet, que se obtiene de la descomposición de n-niveles de cada fase, para identificar fallas en el voltaje en una fase o fallas en la resistencia del estator en máquinas de inducción. El algoritmo propuesto puede funcionar independiente de la frecuencia de operación, tipo de falla y condiciones de carga. Los resultados muestran que este algoritmo tiene una mejor respuesta de detección que las técnicas basadas en la transformada de Fourier.

Traditional Indian medicine (TIM and traditional Korean medicine (TKM: aconstitutional-based concept and comparison

Directory of Open Access Journals (Sweden)

Young Min Kang

2017-06-01

Full Text Available Traditional and complementary medicine (T&CM plays an integral role in providing health care worldwide. It is based on sound fundamental principles and centuries of practices. This study compared traditional Indian medicine (TIM and traditional Korean medicine (TKM basing on data obtained from peer reviewed articles, respective government institutional reports and World Health Organization reports. Despite the fact that TIM and TKM have individual qualities that are unique from each other including different histories of origin, they share a lot in common. Apart from Homeopathy in TIM, both systems are hinged on similar principle of body constitutional-based concept and similar disease diagnosis methods of mainly auscultation, palpation, visual inspection, and interrogation. Similarly, the treatment methods of TIM and TKM follow similar patterns involving use of medicinal herbs, moxibustion, acupuncture, cupping, and manual therapy. Both T&CM are majorly practiced in well-established hospitals by T&CM doctors who have undergone an average of 6–7 years of specialized trainings. However, unlike TIM which has less insurance coverage, the popularity of TKM is majorly due to its wide national insurance coverage. These two medical traditions occupy increasingly greater portion of the global market. However, TIM especially Ayurveda has gained more global recognition than TKM although the emergence of Sasang Constitutional Medicine in TKM is beginning to become more popular. This comparative analysis between TIM and TKM may provide vital and insightful contribution towards constitutional-based concept for further development and future studies in T&CM.

Estudio de las fallas de soldadura en el proceso de fabricación de cilindros de aluminio para g l p

OpenAIRE

Torres Villamar, Artemio; Wiesner Falconi, Ignacio

2009-01-01

El desarrollo del presente trabajo de tesis: Estudio de las fallas de soldadura en el proceso de fabricación de cilindros de aluminio para gas licuado de petróleo, sirve para optimizar la operación de las diferentes etapas del proceso de soldadura, para el efecto se aplicaron técnicas ingenieriles, normas establecidas por el INSTITUTO ECUATORIANO DE NORMALIZACIÓN, como: INEN No. 117 e INEN No. 291 y normas internacionales como ASTM – B209 y ASTM – B211. Se realizaron análisis de fallas en...

Thermal ionisation mass spectrometry (TIMS): what, how and why?

International Nuclear Information System (INIS)

Aggarwal, S.K.

2002-01-01

Thermal ionisation mass spectrometry (TIMS) is one of the oldest mass spectrometric techniques, which has been used for determining the isotopic composition and concentration of different elements using isotope dilution. In spite of the introduction of many other inorganic mass spectrometric techniques like spark source mass spectrometry (SSMS), glow discharge mass spectrometry (GDMS), inductively coupled plasma-mass spectrometry (ICP-MS), secondary ion mass spectrometry (SIMS), the TIMS technique plays the role of a definitive analytical methodology and still occupies a unique position in terms of its capabilities with respect to precision and accuracy as well as sensitivity

Isotopic Ratios of Samarium by TIMS for Nuclear Forensic Application

Energy Technology Data Exchange (ETDEWEB)

Louis Jean, James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Inglis, Jeremy David [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-08-08

The isotopic ratio of Nd, Sm, and Gd can provide important information regarding fissile material (nuclear devices, reactors), neutron environment, and device yield. These studies require precise measurement of Sm isotope ratios, by either TIMS or MC-ICP-MS. There has been an increasing trend to measure smaller and smaller quantities of Sm bearing samples. In nuclear forensics 10-100 ng of Sm are needed for precise measurement. To measure sub-ng Sm samples using TIMS for nuclear forensic analysis.

Paul Dirac lectures at CERN

CERN Multimedia

CERN Bulletin

2010-01-01

When a group of physicists entered the Main Auditorium, during the evening of 29 June, they felt they had opened a time portal.   Paul Dirac in front of a blackboard showing his formula. ©Sandra Hoogeboom An attentive audience, dressed in early 1900 costumes, were watching a lecture by the elusive Paul Dirac, presenting for the first time his famous formula on the blackboard. Paul Adrien Maurice Dirac (1902-1984) was a British mathematical physicist at Cambridge, and one of the "fathers" of quantum mechanics. When he first wrote it, in 1928, Dirac was not sure what his formula really meant. As demonstrated by Andersson four year later, what Dirac had written on the blackboard was the first definition of a positron, hence he is credited with having anticipated the existence of antimatter. The actor John Kohl performs as Paul Dirac. ©Sandra Hoogeboom What the group of puzzled physicists were really observing when they entered the CERN Auditorium was the shoo...

Una estrategia basada en modelos para el diagnóstico de fallas en el estator del motor de inducción

Directory of Open Access Journals (Sweden)

Cristian H. De Angelo

2007-07-01

Full Text Available Resumen: Se presenta una estrategia para el diagnóstico de fallas en el estator de los motores de inducción mediante la información contenida en las tensiones y corrientes de alimentación. La estrategia propuesta está basada en la generación de un vector de residuos específicos por medio de un observador de estados, el cual permite detectar la fase dañada y cuantificar el ńumero de espiras en cortocircuito. La estrategia de diagnóstico es muy poco sensible a los cambios de carga o perturbaciones de la red de alimentación tales como armónicos o desbalances. Palabras clave: Diagnóstico de fallas, fallas en el estator, motor de inducción

Desarrollo de un sistema experto para el diagnostico de fallas automotrices

Directory of Open Access Journals (Sweden)

Fuentes Covarrubias, Ricardo

2013-12-01

Full Text Available Se presenta un prototipo experimental de un sistema experto para el diagnóstico de fallas mecánicas en automóviles, a partir de una interacción en tiempo real. Este sistema es una herramienta de diagnóstico para técnicos mecánicos, practicantes y personas con conocimientos básicos de mecánica automotriz y puede también ser empleado como un sistema tutor inteligente para un curso de mecánica automotriz.

Prevalencia de insuficiencia renal en pacientes que asisten a la clínica de falla cardiaca

Directory of Open Access Journals (Sweden)

Diego Rodríguez, MD

2011-05-01

Conclusiones: la prevalencia de insuficiencia renal determinada por la depuración de creatinina, es alta tanto en hombres como en mujeres evaluados en la clínica de falla cardiaca, lo cual conduce a replantear los esquemas de manejo dependiendo de la función renal ya que algunos de los medicamentos utilizados son nefrotóxicos o incrementan los niveles de potasio. Por lo tanto, la valoración de la función renal mediante la utilización de la depuración de creatinina por medio de la fórmula de Cockcroft, puede ser más conveniente que sólo basarse en la creatinina, por lo cual se recomienda realizarla en todos los pacientes que se estén siguiendo en las clínicas de falla cardiaca al igual que al considerar cambios en el esquema de manejo médico.

Novel effector phenotype of Tim-3+ regulatory T cells leads to enhanced suppressive function in head and neck cancer patients.

Science.gov (United States)

Liu, Zhuqing; McMichael, Elizabeth L; Shayan, Gulidanna; Li, Jing; Chen, Kevin; Srivastava, Raghvendra M; Kane, Lawrence P; Lu, Binfeng; Ferris, Robert L

2018-04-30

Regulatory T (Treg) cells are important suppressive cells among tumor infiltrating lymphocytes (TIL). Treg express the well-known immune checkpoint receptor PD-1, which is reported to mark "exhausted" Treg with lower suppressive function. T cell immunoglobulin mucin (Tim)-3, a negative regulator of Th1 immunity, is expressed by a sizeable fraction of TIL Tregs, but the functional status of Tim-3+ Tregs remains unclear. CD4+CTLA-4+CD25high Treg were sorted from freshly excised head and neck squamous cell carcinoma (HNSCC) TIL based on Tim-3 expression. Functional and phenotypic features of these Tim-3+ and Tim-3- TIL Tregs were tested by in vitro suppression assays and multi-color flow cytometry. Gene expression profiling and NanoString analysis of Tim-3+ TIL Treg were performed. A murine HNSCC tumor model was used to test the effect of anti-PD-1 immunotherapy on Tim-3+ Treg.  Results: Despite high PD-1 expression, Tim-3+ TIL Treg displayed a greater capacity to inhibit naïve T cell proliferation than Tim-3- Treg. Tim-3+ Treg from human HNSCC TIL also displayed an effector-like phenotype, with more robust expression of CTLA-4, PD-1, CD39 and IFN-γ receptor. Exogenous IFN-γ treatment could partially reverse the suppressive function of Tim-3+ TIL Treg. Anti-PD-1 immunotherapy downregulated Tim-3 expression on Tregs isolated from murine HNSCC tumors, and this treatment reversed the suppressive function of HNSCC TIL Tregs. Tim-3+ Treg are functionally and phenotypically distinct in HNSCC TIL, and are highly effective at inhibiting T cell proliferation despite high PD-1 expression.  IFN-γ induced by anti-PD-1 immunotherapy may be beneficial by reversing Tim-3+ Treg suppression. Copyright ©2018, American Association for Cancer Research.

Tim Berners-Lee, World Wide Web inventor

CERN Multimedia

1998-01-01

The "Internet, Web, What's next?" conference on 26 June 1998 at CERN: Tim Berners-Lee, inventor of the World Wide Web and Director of the W3C, explains how the Web came to be and gave his views on the future.

Towards Discovery and Targeted Peptide Biomarker Detection Using nanoESI-TIMS-TOF MS

Science.gov (United States)

Garabedian, Alyssa; Benigni, Paolo; Ramirez, Cesar E.; Baker, Erin S.; Liu, Tao; Smith, Richard D.; Fernandez-Lima, Francisco

2017-09-01

In the present work, the potential of trapped ion mobility spectrometry coupled to TOF mass spectrometry (TIMS-TOF MS) for discovery and targeted monitoring of peptide biomarkers from human-in-mouse xenograft tumor tissue was evaluated. In particular, a TIMS-MS workflow was developed for the detection and quantification of peptide biomarkers using internal heavy analogs, taking advantage of the high mobility resolution (R = 150-250) prior to mass analysis. Five peptide biomarkers were separated, identified, and quantified using offline nanoESI-TIMS-CID-TOF MS; the results were in good agreement with measurements using a traditional LC-ESI-MS/MS proteomics workflow. The TIMS-TOF MS analysis permitted peptide biomarker detection based on accurate mobility, mass measurements, and high sequence coverage for concentrations in the 10-200 nM range, while simultaneously achieving discovery measurements of not initially targeted peptides as markers from the same proteins and, eventually, other proteins. [Figure not available: see fulltext.

Failure problems in superheater spacers of steam generators; Problematica de fallas en espaciadores de sobrecalentadores de generadores de vapor

Energy Technology Data Exchange (ETDEWEB)

Chacon Nava, Jose G; Martinez Villafane, Alberto [Instituto de Investigaciones Electricas, Cuernavaca (Mexico); Fuentes Samaniego, Raul [Universidad Autonoma de Nuevo Leon (Mexico); Mojica Calderon, Cecilio [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

1988-12-31

In this article the general aspects of the steam generator superheater fixed spacers failures are analyzed, emphasis is made on the influence several aspects such as the operation of the unit have, the appropriate execution of welds and the selection of binding materials. Likewise several recommendations are made to bring the failures to a minimum. [Espanol] En este articulo se analizan aspectos generales de fallas en espaciadores fijos de sobrecalentadores de generadores de vapor, y se hace hincapie en la influencia que tienen diversos aspectos tales como la operacion de la unidad, la adecuada ejecucion de soldaduras y la seleccion del material de aporte. Asimismo, se proponen algunas recomendaciones para reducir al minimo las fallas.

TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity

Science.gov (United States)

Angiari, Stefano; Donnarumma, Tiziano; Rossi, Barbara; Dusi, Silvia; Pietronigro, Enrica; Zenaro, Elena; Della Bianca, Vittorina; Toffali, Lara; Piacentino, Gennj; Budui, Simona; Rennert, Paul; Xiao, Sheng; Laudanna, Carlo; Casasnovas, Jose M.; Kuchroo, Vijay K.; Constantin, Gabriela

2014-01-01

SUMMARY Selectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rolling of T helper-1 (Th1) and Th17, but not Th2 and regulatory T cells on P-selectin. Th1 and Th17 cells lacking the TIM-1 mucin domain showed reduced rolling in thrombin-activated mesenteric venules and inflamed brain microcirculation. Inhibition of TIM-1 had no effect on naive T cell homing, but reduced T cell recruitment in a skin hypersensitivity model and blocked experimental autoimmune encephalomyelitis. Uniquely, the TIM-1 IgV domain was also required for P-selectin binding. Our data demonstrate that TIM-1 is a major P-selectin ligand with a specialized role in T cell trafficking during inflammatory responses and the induction of autoimmune disease. PMID:24703780

Paul Dirac

Science.gov (United States)

Pais, Abraham; Jacob, Maurice; Olive, David I.; Atiyah, Michael F.

2005-09-01

Preface Peter Goddard; Dirac memorial address Stephen Hawking; 1. Paul Dirac: aspects of his life and work Abraham Pais; 2. Antimatter Maurice Jacob; 3. The monopole David Olive; 4. The Dirac equation and geometry Michael F. Atiyah.

Sistema para diagnóstico de fallas en transformadores a través de lógica difusa

Directory of Open Access Journals (Sweden)

Madelín Lima Álvarez

2011-02-01

Full Text Available Se expone un sistema para diagnóstico de fallas en transformadores a través de mediciones cromatográficasde los gases disueltos en el aceite y su procesamiento utilizando la lógica difusa, herramientaeficaz de la inteligencia artificial, como método para el diagnóstico. En este caso se escogió de entretodos los modelos cromatográficos existentes para el diagnóstico, el de la norma IEC 599, por ser en laactualidad el de mayor validación experimental. El sistema tiene en cuenta las tres relaciones fundamentalesy las tres relaciones complementarias entre los gases disueltos en el aceite, con vistas a la definición deltipo de falla. También considera la razón del incremento de producción de los gases, para la detección deuna anomalía en el funcionamiento del equipo o de una agravante en el desarrollo de la falla. Por último,se incluye una serie de situaciones en las que no existe una falla totalmente definida por la clasificacióntradicional, emitiéndose un diagnóstico más generalizado.  The following work deals with the presentation of a system for the diagnosis of failures in transformers,through chromatographic measures of the gases dissolved in oil and its process of results using the fuzzylogic, an efficient tool of the artificial intelligence, as method for the diagnosis. In this case thechromatographic model used was chosen from the existent standard IEC 599, for being at present the onewith more experimental validation. The system takes into consideration the three fundamental andcomplementary relationships among the gases dissolved in the oil, in order to define the type of failure. Italso concerns about the increase of gases, for detecting problems in the operation of equipment or offurther difficulties in the development of the failure. Finally, a series of situations where failures not totallydefined in the traditional classification are included providing a wider and more spread diagnosis.

Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis.

Science.gov (United States)

Nozaki, Yuji; Nikolic-Paterson, David J; Snelgrove, Sarah L; Akiba, Hisaya; Yagita, Hideo; Holdsworth, Stephen R; Kitching, A Richard

2012-05-01

The T-cell immunoglobulin mucin 1 (Tim-1) modulates CD4(+) T-cell responses and is also expressed by damaged proximal tubules in the kidney where it is known as kidney injury molecule-1 (Kim-1). We sought to define the role of endogenous Tim-1 in experimental T-cell-mediated glomerulonephritis induced by sheep anti-mouse glomerular basement membrane globulin acting as a planted foreign antigen. Tim-1 is expressed by infiltrating activated CD4(+) cells in this model, and we studied the effects of an inhibitory anti-Tim-1 antibody (RMT1-10) on immune responses and glomerular disease. Crescentic glomerulonephritis, proliferative injury, and leukocyte accumulation were attenuated following treatment with anti-Tim-1 antibodies, but interstitial foxp3(+) cell accumulation and interleukin-10 mRNA were increased. T-cell proliferation and apoptosis decreased in the immune system along with a selective reduction in Th1 and Th17 cellular responses both in the immune system and within the kidney. The urinary excretion and renal expression of Kim-1 was reduced by anti-Tim-1 antibodies reflecting diminished interstitial injury. The effects of anti-Tim-1 antibodies were not apparent in the early phase of renal injury, when the immune response to sheep globulin was developing. Thus, endogenous Tim-1 promotes Th1 and Th17 nephritogenic immune responses and its neutralization reduces renal injury while limiting inflammation in cell-mediated glomerulonephritis.

Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry.

Science.gov (United States)

Rhein, Bethany A; Brouillette, Rachel B; Schaack, Grace A; Chiorini, John A; Maury, Wendy

2016-07-01

Phosphatidylserine (PtdSer) receptors that are responsible for the clearance of dying cells have recently been found to mediate enveloped virus entry. Ebola virus (EBOV), a member of the Filoviridae family of viruses, utilizes PtdSer receptors for entry into target cells. The PtdSer receptors human and murine T-cell immunoglobulin mucin (TIM) domain proteins TIM-1 and TIM-4 mediate filovirus entry by binding to PtdSer on the virion surface via a conserved PtdSer binding pocket within the amino-terminal IgV domain. While the residues within the TIM-1 IgV domain that are important for EBOV entry are characterized, the molecular details of virion-TIM-4 interactions have yet to be investigated. As sequences and structural alignments of the TIM proteins suggest distinct differences in the TIM-1 and TIM-4 IgV domain structures, we sought to characterize TIM-4 IgV domain residues required for EBOV entry. Using vesicular stomatitis virus pseudovirions bearing EBOV glycoprotein (EBOV GP/VSVΔG), we evaluated virus binding and entry into cells expressing TIM-4 molecules mutated within the IgV domain, allowing us to identify residues important for entry. Similar to TIM-1, residues in the PtdSer binding pocket of murine and human TIM-4 (mTIM-4 and hTIM-4) were found to be important for EBOV entry. However, additional TIM-4-specific residues were also found to impact EBOV entry, with a total of 8 mTIM-4 and 14 hTIM-4 IgV domain residues being critical for virion binding and internalization. Together, these findings provide a greater understanding of the interaction of TIM-4 with EBOV virions. With more than 28,000 cases and over 11,000 deaths during the largest and most recent Ebola virus (EBOV) outbreak, there has been increased emphasis on the development of therapeutics against filoviruses. Many therapies under investigation target EBOV cell entry. T-cell immunoglobulin mucin (TIM) domain proteins are cell surface factors important for the entry of many enveloped viruses

In Conversation with Paul Richards

Science.gov (United States)

Holman, Andrew

2013-01-01

Paul Richards is one of those individuals who make a difference and is as far from institutional as one can be. The author met up with him at the Learning Disability Today conference in London to talk more about his work and life. Paul coordinates the service user involvement across Southdown Housing Association, based in Sussex.

Economist Innovation Award for Tim Berners-Lee

CERN Multimedia

2003-01-01

In September, Tim Berners-Lee, who invented the World Wide Web at CERN and is now Director of the W3C World Wide Web Consortium, received the 2nd Economist Annual Innovation Award in Computing. With the award The Economist, a British weekly newspaper, recognises individuals responsible for breakthroughs in Bioscience, Computing, Energy and the Environment, and Telecommunications that have a profound impact on industry. A fifth award is given in a special "No Boundaries" category, observing innovation that transcends industries. Candidates for the awards are proposed by The Economist readers and writers, and by a group of judges. Tim Berners-Lee received the Computing award for his global hypertext project, to be known as the World Wide Web, which "forever altered the way information is shared" and is a huge contribution to the efficiency of the scientific community. Based on a programme for storing information using random associations called "Enquire", it...

Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria.

Science.gov (United States)

Popov-Celeketić, Dusan; Mapa, Koyeli; Neupert, Walter; Mokranjac, Dejana

2008-05-21

The TIM23 (translocase of the mitochondrial inner membrane) complex mediates translocation of preproteins across and their insertion into the mitochondrial inner membrane. How the translocase mediates sorting of preproteins into the two different subcompartments is poorly understood. In particular, it is not clear whether association of two operationally defined parts of the translocase, the membrane-integrated part and the import motor, depends on the activity state of the translocase. We established conditions to in vivo trap the TIM23 complex in different translocation modes. Membrane-integrated part of the complex and import motor were always found in one complex irrespective of whether an arrested preprotein was present or not. Instead, we detected different conformations of the complex in response to the presence and, importantly, the type of preprotein being translocated. Two non-essential subunits of the complex, Tim21 and Pam17, modulate its activity in an antagonistic manner. Our data demonstrate that the TIM23 complex acts as a single structural and functional entity that is actively remodelled to sort preproteins into different mitochondrial subcompartments.

Ära pabista, Sam! / Toomas Paul

Index Scriptorium Estoniae

Paul, Toomas, 1939-

2003-01-01

Inimese võimest leida lohutust täieliku lootusetuse olukorras ja võimetusest ette näha, milliste tulemusteni tema tegevus lõpuks viib. Ilm. ka: Paul, Toomas. Riskiveski krigin // Pastishsh & popurrii : ilmavaatlusi / Paul, Toomas. - [Tallinn] : Oomen, 2007. - Lk. 133-139

Paul Levaux (1931-2012)

CERN Multimedia

2012-01-01

Mr Paul Levaux, a long-standing member of the Belgian delegation to the Finance Committee and Council, passed away on 3 December 2012.   Paul Levaux first attended the CERN Council and Finance Committee in June 1970 as an Advisor, although his association with CERN goes back to the 1960s. From October 1970 until December 2007 he represented Belgium in the capacity of Council and Finance Committee delegate. He was Finance Committee Chairman from 1971 to 1973 and President of Council from 1975 to June 1978. He also served as Vice-President of Council from January 1978 until December 1980 with a second term from January 1994 to December 1997. In addition to holding these important offices, Paul Levaux participated in an extensive number of CERN working groups. In particular, he was a member of the Working Group on Procedures for Payment of Member States' Contributions (2000-2001) and Working Group on the Review of the Tasks and Working Methods of CERN's Governing Bodies and Commi...

Paul Beynel (1944-2012)

CERN Multimedia

2012-01-01

Paul joined the Radiation Group at CERN's Laboratory II in March 1972. He carried out tests on materials and components that were used in the construction of the SPS.   Following the commissioning of the SPS in 1975 and when the two laboratories were merged into one, Paul became a member of the Radiation Protection group. There, he had two roles: the first as a radiation protection officer in the underground areas, where access and personnel protection issues were of crucial importance; and the second testing the radioresistance of many different types of materials. Thanks to his detailed analyses and shrewd interpretation of the results, he became a recognised expert in the field - a recognition that extended far beyond the boundaries of CERN.  He wrote many reports and co-authored several volumes of the CERN "yellow reports" issued as a catalogue on the radioresistance of materials and which continue to serve as reference works today. In July 1988 Paul ha...

Paul Garrin / Paul Garrin ; interv. Tilman Baumgärtel

Index Scriptorium Estoniae

Garrin, Paul

2006-01-01

1997. a. New York Citys tehtud intervjuu ameerika kunstniku, firma pgMedia rajaja ja omaniku Paul Garriniga (sünd. 1952). P. Garrini videotest, pikemalt videost "Free Society", Internetiga tegelemisest, projektist "Mediafilter", interaktiivsetest installatsioonidest, domeeninimede registreerimise projektist "name.space"

Efecto de los inotrópicos sobre la mortalidad en falla cardiaca aguda. Metaanálisis en red de ensayos clínicos

OpenAIRE

Juan M. Sénior; Edison Muñoz; James Díaz

2017-01-01

Introducción: en pacientes con falla cardiaca aguda es necesario el uso de inotrópicos para lograr su estabilización. Objetivo: definir cuál de los medicamentos inotrópicos se asocia con menor mortalidad. Metodología: se realizó un metaanálisis en red con la aproximación frecuentista. La búsqueda sistemática incluyó PUBMED, EMBASE, CENTRAL, DARE, Epistemonikos, SieELO, LILACS y OpenGray. Se incluyeron ensayos clínicos con asignación aleatoria en pacientes con falla cardiaca aguda que re...

Interview : Paul Paulus on group creativity

NARCIS (Netherlands)

Harms, Rainer; Van Der Zee, Karen

Paul Paulus is Distinguished Professor of Psychology at the Department of Psychology, University of Texas at Arlington. Paul Paulus's research interests revolve around Group Creativity: On the one hand, creative processes are often conceptualized as individual-level phenomena. On the other hand,

Interview: Paul Paulus on group creativity

NARCIS (Netherlands)

Harms, Rainer; van der Zee, Karen

2013-01-01

Paul Paulus is Distinguished Professor of Psychology at the Department of Psychology, University of Texas at Arlington. Paul Paulus's research interests revolve around Group Creativity: On the one hand, creative processes are often conceptualized as individual-level phenomena. On the other hand,

TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway.

Directory of Open Access Journals (Sweden)

Brian Tomkowicz

Full Text Available TIM-3 (T cell immunoglobulin and mucin-domain containing protein 3 is a member of the TIM family of proteins that is preferentially expressed on Th1 polarized CD4+ and CD8+ T cells. Recent studies indicate that TIM-3 serves as a negative regulator of T cell function (i.e. T cell dependent immune responses, proliferation, tolerance, and exhaustion. Despite having no recognizable inhibitory signaling motifs, the intracellular tail of TIM-3 is apparently indispensable for function. Specifically, the conserved residues Y265/Y272 and surrounding amino acids appear to be critical for function. Mechanistically, several studies suggest that TIM-3 can associate with interleukin inducible T cell kinase (ITK, the Src kinases Fyn and Lck, and the p85 phosphatidylinositol 3-kinase (PI3K adaptor protein to positively or negatively regulate IL-2 production via NF-κB/NFAT signaling pathways. To begin to address this discrepancy, we examined the effect of TIM-3 in two model systems. First, we generated several Jurkat T cell lines stably expressing human TIM-3 or murine CD28-ECD/human TIM-3 intracellular tail chimeras and examined the effects that TIM-3 exerts on T cell Receptor (TCR-mediated activation, cytokine secretion, promoter activity, and protein kinase association. In this model, our results demonstrate that TIM-3 inhibits several TCR-mediated phenotypes: i NF-kB/NFAT activation, ii CD69 expression, and iii suppression of IL-2 secretion. To confirm our Jurkat cell observations we developed a primary human CD8+ cell system that expresses endogenous levels of TIM-3. Upon TCR ligation, we observed the loss of NFAT reporter activity and IL-2 secretion, and identified the association of Src kinase Lck, and PLC-γ with TIM-3. Taken together, our results support the conclusion that TIM-3 is a negative regulator of TCR-function by attenuating activation signals mediated by CD3/CD28 co-stimulation.

Perfiles clínicos y hemodinámicos en pacientes con falla cardiaca aguda

Directory of Open Access Journals (Sweden)

Luis Eduardo Calderón

2017-09-01

Conclusiones: la falla cardíaca aguda descompensada es el perfil de presentación clínica más común en nuestra población con dos tercios del total de casos. El perfil hemodinámico más frecuente fue el “caliente y húmedo” (Stevenson B, resultados que concuerdan con lo observado en estudios locales y registros internacionales.

Tim de Zeeuw to Become the Next Director General of ESO

Science.gov (United States)

2007-01-01

The ESO Council has just appointed Tim de Zeeuw, 50, as the next Director General of ESO, effective as of 1 September 2007, when the current Director General, Catherine Cesarsky will complete her mandate. ESO PR Photo 02/07 ESO PR Photo 03/07 Professor Tim de Zeeuw "ESO is Europe's flagship organisation for ground-based astronomy," said, Richard Wade, President of the ESO Council. "The ESO Council is very pleased that Professor de Zeeuw has accepted the task as its next Director General. He has played a key role over the last few years in developing a strategic vision for ESO, and I have every confidence that he will now lead the organisation in the realisation of that exciting vision." Tim de Zeeuw has an excellent record, both as a highly respected scientist and as a leader of an internationally recognised science institute in the Netherlands. He is Scientific Director of the Leiden Observatory, a research institute in the College of Mathematics and Natural Sciences of Leiden University. Tim de Zeeuw also has considerable experience as regards science policy issues. Catherine Cesarsky, ESO's current Director General commented: "Over the recent years, ESO has developed considerably with more activities and new member states, and with its ambitious project portfolio, ESO is clearly facing an exciting future. I shall be delighted to pass the baton to Tim de Zeeuw, who as a recent Council member is very familiar with our Organisation." "It is a great honour and an exciting challenge to lead this world-class organisation in the years to come in support of one of the most dynamic areas of science today," said de Zeeuw. "I look forward to overseeing the continued upgrading of the Very Large Telescope with the second-generation instrumentation and the completion of the ALMA project, and in particular to help developing the future European Extremely Large Telescope." Tim de Zeeuw's main research interests embrace the formation, structure and dynamics of galaxies

[Heinz von zur Mühlen. Paul Johansen und die Sogenannten Undeutschen in Reval/Tallinn] / Paul Kaegbein

Index Scriptorium Estoniae

Kaegbein, Paul

2008-01-01

Arvustus: Heinz von zur Mühlen. Paul Johansen und die Sogenannten Undeutschen in Reval/Tallinn. - Nordosteuropa als Geschichtsregion. Helsinki : Aue-Stiftung :; Lübeck : Schmidt-Römhild, 2006. lk. 103-111. Paul Johanseni lähim töökaaslane kirjeldab teose "Deutsch und Undeutsch im mittelalterlichen und frühneuzeitlichen Reval" valmimist

Paul Callaghan luminous moments

CERN Document Server

Callaghan, Paul

2013-01-01

Acknowledged internationally for his ground-breaking scientific research in the field of magnetic resonance, Sir Paul Callaghan was a scientist and visionary with a rare gift for promoting science to a wide audience. He was named New Zealander of the Year in 2011. His death in early 2012 robbed New Zealand of an inspirational leader. Paul Callaghan: Luminous Moments brings together some of his most significant writing. Whether he describes his childhood in Wanganui, reflects on discovering the beauty of science, sets out New Zealand's future potential or discusses the experience of fa

Desarrollo de un sistema experto para el diagnostico de fallas automotrices

OpenAIRE

Fuentes Covarrubias, Ricardo; Fuentes Covarrubias, Andrés Gerardo

2013-01-01

Se presenta un prototipo experimental de un sistema experto para el diagnóstico de fallas mecánicas en automóviles, a partir de una interacción en tiempo real. Este sistema es una herramienta de diagnóstico para técnicos mecánicos, practicantes y personas con conocimientos básicos de mecánica automotriz y puede también ser empleado como un sistema tutor inteligente para un curso de mecánica automotriz. In this paper we present an experimental prototype of an expert system for the diagnosis...

Aneurisma de la vena de Galeno como causa de falla cardíaca Galen's vein aneurysm as cause of heart failure

Directory of Open Access Journals (Sweden)

Claudia Echeverría

2005-04-01

Full Text Available Se presenta el caso de un recién nacido que ingresa a cuidado intensivo con un cuadro de falla cardiaca de difícil manejo con ductus arterioso de gran tamaño, a quien se le realizó cierre quirúrgico del mismo y pese a ello persistía con clínica de falla cardiaca que no mejoraba con tratamiento médico. Se hizo un hallazgo incidental de un aneurisma de la vena de Galeno de gran tamaño. El aneurisma de la vena de Galeno es una patología congénita poco frecuente que se origina de un defecto en la fusión de las venas cerebrales internas, debido a la baja resistencia produce un cuadro de falla cardiaca de alto gasto. Los defectos de gran tamaño pueden contener entre 50% a 60% del gasto cardiaco. Se debe sospechar aneurisma en todo recién nacido o lactante menor con cuadro de falla cardíaca y dilatación de cavidades derechas sin evidencia de anomalía cardíaca estructural.We present the case of a newborn admitted to the intensive care unit with a heart failure of difficult medical management. A large ductus arteriosus was found. It was surgically corrected, but the heart failure persisted and did not improve with medical treatment. Incidentally, a big Galen's vein aneurysm was found. Galen's vein aneurysm is a rare congenital pathology, originated by a fusion defect of the internal cerebral veins. Due to its low resistance, it produces a picture of high-output heart failure. Large defects may contain 50% to 60% of cardiac output. An aneurysm may be suspected in each newborn or infant with clinical picture of heart failure and right cardiac chamber dilation without any evidence of structural cardiac anomaly.

Análisis de paleoesfuerzos mediante datos de fallas estriadas en el “stock” de chinchiná-santa rosa, en la cantera la virgen manizales, caldas

OpenAIRE

Gómez-Hurtado, Eliana; Marín-Marín, Juan Sebastián; Hincapié-Jaramillo, Gustavo

2012-01-01

Eliana Gómez-Hurtado1, Juan Sebastián Marín-Marín1, & Gustavo Hincapié-Jaramillo 2 1 Estudiante programa de Geología, Universidad de Caldas, Manizales, Caldas , 2Profesor Departamento de Ciencias Geológicas, Universidad de Caldas, Manizales, Caldas Falla Silvia Pijao pertenece al Sistema de Fallas de Romeral y pone en contacto rocas de los complejos Quebradagrande (al este) y Arquía (al oeste). El “Stock” ...

El De imaginibus caelestibus de Ibn al-Ḥātim

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Oliveras, Marc

2009-06-01

Full Text Available K. Lippincott and D. Pingree published in 1987 a first Latin edition and English translation of the 15^th bilingual Arabic-Latin De imaginibus caelestibus, written originally by the Andalusian Ibn al-Ḥātim in the 10th century. The paper presented here aims to complete the preceding one with an Arabic edition, Spanish translation and some interpretations on the possible sources of talismanic imagery. In this brief astromagic treatise, Ibn al-Ḥātim focuses on twenty eight talismans, related to the lunar mansions, and their magical properties.

En 1987 K. Lippincott y D. Pingree publicaron una primera edición latina junto a una traducción inglesa del tratado bilingüe árabo-latino del s. XV De imaginibus caelestibus, escrito originariamente por el andalusí Ibn al-Ḥātim en el s. X. El trabajo que se presenta aquí pretende completar al precedente con una edición del texto árabe, su traducción al español y añadir algunas interpretaciones a las posibles fuentes de la imaginería talismánica. En este breve tratado de astromagia, Ibn al-Ḥātim se dedica principalmente a describir veintiocho talismanes, relacionados con las mansiones lunares, y sus propiedades mágicas.

T-bet-mediated Tim-3 expression dampens monocyte function during chronic hepatitis C virus infection.

Science.gov (United States)

Yi, Wenjing; Zhang, Peixin; Liang, Yan; Zhou, Yun; Shen, Huanjun; Fan, Chao; Moorman, Jonathan P; Yao, Zhi Q; Jia, Zhansheng; Zhang, Ying

2017-03-01

Hepatitis C virus (HCV) induces a high rate of chronic infection via dysregulation of host immunity. We have previously shown that T-cell immunoglobulin and mucin domain protein-3 (Tim-3) is up-regulated on monocyte/macrophages (M/Mφ) during chronic HCV infection; little is known, however, about the transcription factor that controls its expression in these cells. In this study, we investigated the role of transcription factor, T-box expressed in T cells (T-bet), in Tim-3 expression in M/Mφ in the setting of HCV infection. We demonstrate that T-bet is constitutively expressed in resting CD14 + M/Mφ in the peripheral blood. M/Mφ from chronically HCV-infected individuals exhibit a significant increase in T-bet expression that positively correlates with an increased level of Tim-3 expression. Up-regulation of T-bet is also observed in CD14 + M/Mφ incubated with HCV + Huh7.5 cells, as well as in primary M/Mφ or monocytic THP-1 cells exposed to HCV core protein in vitro, which is reversible by blocking HCV core/gC1qR interactions. Moreover, the HCV core-induced up-regulation of T-bet and Tim-3 expression in M/Mφ can be abrogated by incubating the cells with SP600125 - an inhibitor for the c-Jun N-terminal kinase (JNK) signalling pathway. Importantly, silencing T-bet gene expression decreases Tim-3 expression and enhances interleukin-12 secretion as well as signal transducer and activator of transcription 1 phosphorylation. These data suggest that T-bet, induced by the HCV core/gC1qR interaction, enhances Tim-3 expression via the JNK pathway, leading to dampened M/Mφ function during HCV infection. These findings reveal a novel mechanism for Tim-3 regulation via T-bet during HCV infection, providing new targets to combat this global epidemic viral disease. © 2016 John Wiley & Sons Ltd.

Mosaico del cromosoma X en diferentes tejidos de pacientes con falla ovárica prematura

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M.E. Arteaga Espinosa

2015-06-01

Conclusión: La existencia de mosaicismo de bajo grado puede ser la causa de falla ovárica prematura. Este estudio indica que es necesario más de un tipo de tejido para identificar el mosaicismo de bajo grado. Por ello, el estudio de células del urotelio puede incluirse dentro del abordaje diagnóstico de las pacientes con esta enfermedad.

TIM1 (HAVCR1 Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions

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Anshuman Das

2017-09-01

Full Text Available Receptor molecules play key roles in the cellular entry of picornaviruses, and TIM1 (HAVCR1 is widely accepted to be the receptor for hepatitis A virus (HAV, an unusual, hepatotropic human picornavirus. However, its identification as the hepatovirus receptor predated the discovery that hepatoviruses undergo nonlytic release from infected cells as membrane-cloaked, quasi-enveloped HAV (eHAV virions that enter cells via a pathway distinct from naked, nonenveloped virions. We thus revisited the role of TIM1 in hepatovirus entry, examining both adherence and infection/replication in cells with clustered regularly interspaced short palindromic repeat (CRISPR/Cas9-engineered TIM1 knockout. Cell culture-derived, gradient-purified eHAV bound Huh-7.5 human hepatoma cells less efficiently than naked HAV at 4°C, but eliminating TIM1 expression caused no difference in adherence of either form of HAV, nor any impact on infection and replication in these cells. In contrast, TIM1-deficient Vero cells showed a modest reduction in quasi-enveloped eHAV (but not naked HAV attachment and replication. Thus, TIM1 facilitates quasi-enveloped eHAV entry in Vero cells, most likely by binding phosphatidylserine (PtdSer residues on the eHAV membrane. Both Tim1−/− Ifnar1−/− and Tim4−/− Ifnar1−/− double-knockout mice were susceptible to infection upon intravenous challenge with infected liver homogenate, with fecal HAV shedding and serum alanine aminotransferase (ALT elevations similar to those in Ifnar1−/− mice. However, intrahepatic HAV RNA and ALT elevations were modestly reduced in Tim1−/−Ifnar1−/− mice compared to Ifnar1−/− mice challenged with a lower titer of gradient-purified HAV or eHAV. We conclude that TIM1 is not an essential hepatovirus entry factor, although its PtdSer-binding activity may contribute to the spread of quasi-enveloped virus and liver injury in mice.

Towards Discovery and Targeted Peptide Biomarker Detection Using nanoESI-TIMS-TOF MS

Energy Technology Data Exchange (ETDEWEB)

Garabedian, Alyssa; Benigni, Paolo; Ramirez, Cesar; Baker, Erin M.; Liu, Tao; Smith, Richard D.; Fernandez-Lima, Francisco

2018-05-01

Abstract. In the present work, the potential of trapped ion mobility spectrometry coupled to TOF mass spectrometry (TIMS-TOF MS) for discovery and targeted monitoring of peptide biomarkers from human-in-mouse xenograft tumor tissue was evaluated. In particular, a TIMS-MS workflow was developed for the detection and quantification of peptide biomarkers using internal heavy analogs, taking advantage of the high mobility resolution (R = 150–250) prior to mass analysis. Five peptide biomarkers were separated, identified, and quantified using offline nanoESI-TIMSCID- TOF MS; the results were in good agreement with measurements using a traditional LC-ESI-MS/MS proteomics workflow. The TIMS-TOF MS analysis permitted peptide biomarker detection based on accurate mobility, mass measurements, and high sequence coverage for concentrations in the 10–200 nM range, while simultaneously achieving discovery measurements

Heavy metal contamination in TIMS Branch sediments

International Nuclear Information System (INIS)

Pickett, J.B.

1990-01-01

The objective of this memorandum is to summarize results of previous sediment studies on Tims Branch and Steed's Pond conducted by Health Protection (HP) and by the Savannah River Laboratory (SRL) in conjunction with Reactor Materials Engineering ampersand Technology (RMET). The results for other heavy metals, such as lead, nickel, copper, mercury, chromium, cadmium, zinc, and thorium are also summarized

Sild humanitaar- ja loodusteaduste vahel : intervjuu Aberdeeni ülikooli sotsiaalantropoloogia professori Tim Ingoldiga / Tim Ingold ; interv. Alo Joosepson, Kaie Kotov, Silver Rattasepp, Riste Keskpaik

Index Scriptorium Estoniae

Ingold, Tim

2004-01-01

4. rahvusvahelise keskkonnaesteetika ja -semiootika konverentsi "Kultuur, loodus, semiootika: kohad" üks peaesineja Tim Ingold tegeleb 1990-ndatest alates antropoloogia ja kunsti suhte uurimisega ning loeb kursust "Antropoloogia, arheoloogia, kunst ja arhitektuur"

James Peacock, Understanding Paul Auster

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Chrysavgi Papayianni

2011-10-01

Full Text Available Paul Auster’s impressive gamut of work continues to incite fascination and controversy. Indeed, his compelling storytelling style taken together with his mixing of crime fiction and absurdism has made his readers and critics vacillate between praise and condemnation. James Peacock’s Understanding Paul Auster, sheds new light to otherwise obscure aspects of Auster’s novels, films, and other works undermining in this way the negative criticism of the past and thus creating a new appreciation fo...

Tim Berners-Lee: inventor de la World Wide Web

OpenAIRE

Universidad de Granada. Biblioteca

2015-01-01

El presente Cat??logo contiene la exposici??n organizada por la Biblioteca de la ETSIIT de la Universidad de Granada durante los meses de noviembre-diciembre de 2015 y titulada: "Tim Berners-Lee: inventor de la World Wide Web"

Reversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteins.

Science.gov (United States)

Romero-Romero, Sergio; Costas, Miguel; Rodríguez-Romero, Adela; Alejandro Fernández-Velasco, D

2015-08-28

Temperature is one of the main variables that modulate protein function and stability. Thermodynamic studies of oligomeric proteins, the dominant protein natural form, have been often hampered because irreversible aggregation and/or slow reactions are common. There are no reports on the reversible equilibrium thermal unfolding of proteins composed of (β/α)8 barrel subunits, albeit this "TIM barrel" topology is one of the most abundant and versatile in nature. We studied the eponymous TIM barrel, triosephosphate isomerase (TIM), belonging to five species of different bacterial taxa. All of them were found to be catalytically efficient dimers. The three-dimensional structure of four enzymes was solved at high/medium resolution. Irreversibility and kinetic control were observed in the thermal unfolding of two TIMs, while for the other three the thermal unfolding was found to follow a two-state equilibrium reversible process. Shifts in the global stability curves of these three proteins are related to the organismal temperature range of optimal growth and modulated by variations in maximum stability temperature and in the enthalpy change at that temperature. Reversibility appears to correlate with the low isoelectric point, the absence of a residual structure in the unfolded state, small cavity volume in the native state, low conformational stability and a low melting temperature. Furthermore, the strong coupling between dimer dissociation and monomer unfolding may reduce aggregation and favour reversibility. It is therefore very thought-provoking to find that a common topological ensemble, such as the TIM barrel, can unfold/refold in the Anfinsen way, i.e. without the help of the cellular machinery.

The intermediate state in Paul

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N. S. L. Fryer

1987-01-01

Full Text Available The point of view taken in this paper is that the apostle Paul envisions, between death and the resurrection of the body at the Parousia, an interim period during which the disembodied soul is in the immediate presence of Christ, though in a state of 'nakedness'. The background of Paul's view lies neither in contemporary Hellenistic religious-philosophical speculations nor in 'late-Judaism'. Two crucial 'forces' in particular moulded his perspective, viz the teachings of Jesus and His own rapture to 'Paradise'.

Interaction between Galectin-9/TIM-3 pathway and follicular helper CD4+ T cells contributes to viral persistence in chronic hepatitis C.

Science.gov (United States)

Zhuo, Ya; Zhang, Yi-Fu; Wu, Hong-Jie; Qin, Lei; Wang, Yan-Ping; Liu, A-Min; Wang, Xin-Hong

2017-10-01

Both Galectin 9 (Gal-9)/T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) pathway and follicular helper CD4 + T (Tfh) cells play important roles in persistent hepatitis C virus (HCV) infection. Thus, we aimed to investigate the regulatory role of interaction between Gal-9/TIM-3 pathway and Tfh cells in chronic hepatitis C. A total of 44 chronic hepatitis C patients and 19 normal controls (NCs) were enrolled in this study. Purified CD4 + T cells were cultured by TIM-3 Fc protein, recombinant Gal-9, or IL-21 for 48h. TIM-3 expression, Tfh proportion, and IL-21 production was measured, respectively. The immunomodulatory role of Gal-9/TIM-3 and IL-21 was also investigated in HCV cell culture system in vitro. We found that the percentage corresponding to both TIM-3-positive and CXCR5 + ICOS + Tfh cells within CD4 + T cells, which correlated with HCV RNA replication, was significantly elevated in patients with chronic hepatitis C in comparison with those in NCs. Moreover, blockade of Gal-9/TIM-3 pathway by TIM-3 Fc protein increased Tfh cells proportion, IL-21 mRNA and protein expression within purified CD4 + T cells, while activation of Gal-9/TIM-3 signaling by Gal-9 stimulation decreased IL-21 production in both patients with chronic HCV infection and healthy individuals. Meanwhile, high concentrations (100 and 200ng/mL) of IL-21 stimulation also elevated TIM-3 expression on CD4 + T cells in chronic hepatitis C. Furthermore, TIM-3 blockage and IL-21 stimulation suppressed mRNA expressions of HCV-induced antiviral proteins (myxovirus resistance A and oligoadenylate synthetase) in Huh7.5 cells without affecting viral replication in HCV cell culture system. The interaction between Gal-9/TIM-3 pathway and Tfh cells contributed to viral persistent in chronic HCV infection, which might be pivotal for development of new therapeutic approaches for chronic hepatitis C. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Upregulation of Tim-3 on CD4(+) T cells is associated with Th1/Th2 imbalance in patients with allergic asthma.

Science.gov (United States)

Tang, Fei; Wang, Fukun; An, Liyun; Wang, Xianling

2015-01-01

T cell Ig and mucin domain-containing molecule-3 (Tim-3) is a negative regulator preferentially expressed on Th1 cells. Allergic asthma is a clinical syndrome well characterized by Th1/Th2 imbalance. To investigate the role of Tim-3 in the pathogenesis of asthma and its relationship with Th1/Th2 imbalance, a total of 40 patients with allergic asthma and 40 healthy controls were enrolled. Expression of Tim-3 and Th1/Th2 imbalance as well as the relationship between them was analyzed by flow cytometry and real-time PCR. Peripheral blood mononuclear cells (PBMCs) were cultured in vitro and anti-Tim-3 was used to block Tim-3 signaling; Th1/Th2 cytokines in the culture supernatant were detected by enzyme linked immunosorbent assay (ELISA). CD4(+) T cells and B cells were sorted and co-cultured in vitro, and anti-Tim-3 was used to block Tim-3 signaling; Total IgG/IgE in the culture supernatant was detected by ELISA. The mRNA level of T-bet and IFN-γ were significantly decreased in allergic asthma patients, while GATA-3 and IL-4 were significantly increased. Expression of Tim-3 on CD4(+) T cells was much higher in allergic asthma patients and it was negatively correlated with T-bet/GATA-3 ratio or IFN-γ/IL-4 ratio. Blocking of Tim-3 significantly increased Th1 cytokines (TNF-α and IFN-γ) and decreased Th2 cytokines (IL-4, IL-5, IL-13) in the culture supernatant of PBMCs. Blocking of Tim-3 dramatically reduced the production of IgG and IgE in the co-culture supernatant of CD4(+) T cells and B cells. In conclusion, Tim-3 was up-regulated in allergic asthma patients and related with the Th1/Th2 imbalance. Blocking of Tim-3 may be of therapeutic benefit by enhancing the Th1 cytokines response, down-regulating the Th2 cytokines response, and reducing IgG/IgE production.

TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions.

Science.gov (United States)

Das, Anshuman; Hirai-Yuki, Asuka; González-López, Olga; Rhein, Bethany; Moller-Tank, Sven; Brouillette, Rachel; Hensley, Lucinda; Misumi, Ichiro; Lovell, William; Cullen, John M; Whitmire, Jason K; Maury, Wendy; Lemon, Stanley M

2017-09-05

Receptor molecules play key roles in the cellular entry of picornaviruses, and TIM1 (HAVCR1) is widely accepted to be the receptor for hepatitis A virus (HAV), an unusual, hepatotropic human picornavirus. However, its identification as the hepatovirus receptor predated the discovery that hepatoviruses undergo nonlytic release from infected cells as membrane-cloaked, quasi-enveloped HAV (eHAV) virions that enter cells via a pathway distinct from naked, nonenveloped virions. We thus revisited the role of TIM1 in hepatovirus entry, examining both adherence and infection/replication in cells with clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9-engineered TIM1 knockout. Cell culture-derived, gradient-purified eHAV bound Huh-7.5 human hepatoma cells less efficiently than naked HAV at 4°C, but eliminating TIM1 expression caused no difference in adherence of either form of HAV, nor any impact on infection and replication in these cells. In contrast, TIM1-deficient Vero cells showed a modest reduction in quasi-enveloped eHAV (but not naked HAV) attachment and replication. Thus, TIM1 facilitates quasi-enveloped eHAV entry in Vero cells, most likely by binding phosphatidylserine (PtdSer) residues on the eHAV membrane. Both Tim1 -/- Ifnar1 -/- and Tim4 -/- Ifnar1 -/- double-knockout mice were susceptible to infection upon intravenous challenge with infected liver homogenate, with fecal HAV shedding and serum alanine aminotransferase (ALT) elevations similar to those in Ifnar1 -/- mice. However, intrahepatic HAV RNA and ALT elevations were modestly reduced in Tim1 -/- Ifnar1 -/- mice compared to Ifnar1 -/- mice challenged with a lower titer of gradient-purified HAV or eHAV. We conclude that TIM1 is not an essential hepatovirus entry factor, although its PtdSer-binding activity may contribute to the spread of quasi-enveloped virus and liver injury in mice. IMPORTANCE T cell immunoglobulin and mucin-containing domain protein 1 (TIM1) was reported more than

Tim-3/galectin-9 regulate the homeostasis of hepatic NKT cells in a murine model of nonalcoholic fatty liver disease.

Science.gov (United States)

Tang, Zhao-Hui; Liang, Shuwen; Potter, James; Jiang, Xuan; Mao, Hai-Quan; Li, Zhiping

2013-02-15

T cell Ig and mucin domain (Tim)-3 is well known to interact with its natural ligand, Galectin-9 (Gal-9), to regulate T cell function. However, little is known about the function of Tim-3/Gal-9 signaling in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) mediated by hepatic NKT cells that also express Tim-3. In the current study, we define the role and the mechanism of Tim-3/Gal-9 signaling in hepatic NKT cell regulation in a mouse model of diet-induced NAFLD. Adult male wild-type or CD1d knockout C57BL/6 mice were fed a high-fat diet to induce steatosis. Some of the mice also received one or a combination of Gal-9, anti-IL-15R/IL-15 mAb, rIL-15, α-galactosylceramide, and multilamellar liposomes containing Cl(2)MDP. The expression of Tim-3 and various markers reflecting cell proliferation, activation, cytokine production, and apoptosis was analyzed. Liver histology, steatosis grade, and hepatic triglyceride content were also evaluated. In the liver, Tim-3(+) NKT cells are in an activated state, and Gal-9 directly induces Tim-3(+) NKT cell apoptosis and contributes to the depletion of NKT cells in diet-induced steatosis. However, Gal-9 also interacts with Tim-3-expressing Kupffer cells to induce secretion of IL-15, thus promoting NKT cell proliferation. Exogenous administration of Gal-9 significantly ameliorates diet-induced steatosis by modulating hepatic NKT cell function. In summary, the Tim-3/Gal-9-signaling pathway plays a critical role in the homeostasis of hepatic NKT cells through activation-induced apoptosis and secondary proliferation and, thus, contributes to the pathogenesis of NAFLD.

Tim-3/Galectin-9 Regulate the Homeostasis of Hepatic NKT Cells in a Murine Model of Nonalcoholic Fatty Liver Disease

Science.gov (United States)

Liang, Shuwen; Potter, James; Jiang, Xuan; Mao, Hai-Quan

2013-01-01

T cell Ig and mucin domain (Tim)-3 is well known to interact with its natural ligand, Galectin-9 (Gal-9), to regulate T cell function. However, little is known about the function of Tim-3/Gal-9 signaling in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) mediated by hepatic NKT cells that also express Tim-3. In the current study, we define the role and the mechanism of Tim-3/Gal-9 signaling in hepatic NKT cell regulation in a mouse model of diet-induced NAFLD. Adult male wild-type or CD1d knockout C57BL/6 mice were fed a high-fat diet to induce steatosis. Some of the mice also received one or a combination of Gal-9, anti–IL-15R/IL-15 mAb, rIL-15, α-galactosylceramide, and multilamellar liposomes containing Cl2MDP. The expression of Tim-3 and various markers reflecting cell proliferation, activation, cytokine production, and apoptosis was analyzed. Liver histology, steatosis grade, and hepatic triglyceride content were also evaluated. In the liver, Tim-3+ NKT cells are in an activated state, and Gal-9 directly induces Tim-3+ NKT cell apoptosis and contributes to the depletion of NKT cells in diet-induced steatosis. However, Gal-9 also interacts with Tim-3–expressing Kupffer cells to induce secretion of IL-15, thus promoting NKT cell proliferation. Exogenous administration of Gal-9 significantly ameliorates diet-induced steatosis by modulating hepatic NKT cell function. In summary, the Tim-3/Gal-9–signaling pathway plays a critical role in the homeostasis of hepatic NKT cells through activation-induced apoptosis and secondary proliferation and, thus, contributes to the pathogenesis of NAFLD. PMID:23296703

Detecting and classifying faults on transmission systems using a backpropagation neural network; Deteccion y clasificacion de fallas en sistemas de transmision empleando una red neuronal con retropropagacion del error

Energy Technology Data Exchange (ETDEWEB)

Rosas Ortiz, German

2000-01-01

Fault detection and diagnosis on transmission systems is an interesting area of investigation to Artificial Intelligence (AI) based systems. Neurocomputing is one of fastest growing areas of research in the fields of AI and pattern recognition. This work explores the possible suitability of pattern recognition approach of neural networks for fault detection and classification on power systems. The conventional detection techniques in modern relays are based in digital processing of signals and it need some time (around 1 cycle) to send a tripping signal, also they are likely to make incorrect decisions if the signals are noisy. It's desirable to develop a fast, accurate and robust approach that perform accurately for changing system conditions (like load variations and fault resistance). The aim of this work is to develop a novel technique based on Artificial Neural Networks (ANN), which explores the suitability of a pattern classification approach for fault detection and diagnosis. The suggested approach is based in the fact that when a fault occurs, a change in the system impedance take place and, as a consequence changes in amplitude and phase of line voltage and current signals take place. The ANN-based fault discriminator is trained to detect this changes as indicators of the instant of fault inception. This detector uses instantaneous values of these signals to make decisions. Suitability of using neural network as pattern classifiers for transmission systems fault diagnosis is described in detail a neural network design and simulation environment for real-time is presented. Results showing the performance of this approach are presented and indicate that it is fast, secure and exact enough, and it can be used in high speed fault detection and classification schemes. [Spanish] El diagnostico y la deteccion de fallas en sistemas de transmision es una area de interes en investigacion para sistemas basados en Inteligencia Artificial (IA). El calculo neuronal

Inverse European Latitudinal Cline at the timeless Locus of Drosophila melanogaster Reveals Selection on a Clock Gene: Population Genetics of ls-tim.

Science.gov (United States)

Zonato, Valeria; Vanin, Stefano; Costa, Rodolfo; Tauber, Eran; Kyriacou, Charalambos P

2018-02-01

The spread of adaptive genetic variants in populations is a cornerstone of evolutionary theory but with relatively few biologically well-understood examples. Previous work on the ls-tim variant of timeless, which encodes the light-sensitive circadian regulator in Drosophila melanogaster, suggests that it may have originated in southeastern Italy. Flies characterized by the new allele show photoperiod-related phenotypes likely to be adaptive in seasonal environments. ls-tim may be spreading from its point of origin in Italy by directional selection, but there are alternative explanations for its observed clinal geographical distribution, including balancing selection and demography. From population analyses of ls-tim frequencies collected on the eastern side of the Iberian Peninsula, we show that ls-tim frequencies are inverted compared with those in Italy. This pattern is consistent with a scenario of directional selection rather than latitude-associated balancing selection. Neutrality tests further reveal the signature of directional selection at the ls-tim site, which is reduced a few kb pairs either side of ls-tim. A reanalysis of allele frequencies from a large number of microsatellite loci do not demonstrate any frequent ls-tim-like spatial patterns, so a general demographic effect or population expansion from southeastern Italy cannot readily explain current ls-tim frequencies. Finally, a revised estimate of the age of ls-tim allele using linkage disequilibrium and coalescent-based approaches reveals that it may be only 300 to 3000 years old, perhaps explaining why it has not yet gone to fixation. ls-tim thus provides a rare temporal snapshot of a new allele that has come under selection before it reaches equilibrium.

Paul Falk-Vairant, 1921-2001

CERN Multimedia

2001-01-01

Paul Falk-Vairant died on 9 March 2001, a few weeks before his eightieth birthday. A physicist with dual Swiss and French nationality, he left his mark on particle physics in France and had a great impact on the development of CERN. Educated at the Swiss Federal Polytechnic at Zürich, Paul Falk-Vairant arrived in France in 1947 to study for a thesis at the Radium Institute in Paris. Up until 1973, he was employed successively by the French CNRS, CEA and the University of Paris. During the same period, he came to lead the first experiment at CERN run by physicists from outside institutes at the PS. In 1971, he chaired the ECFA (European Committee for Future Accelerators) working group on SPS physics. It was therefore natural for CERN in 1972 to invite him to take over its research policy. From 1973 to 1976, he occupied the position of Director of Physics I Department at CERN before becoming Research Director for the whole of CERN until 1978. At the same time Paul Falk-Vairant guided the experimental...

Paul Ehrenfest

International Nuclear Information System (INIS)

Broda, E.

1982-01-01

This is a short biography about Paul Ehrenfest, a famous austrian physicist and student of Ludwig Boltzmann. Ehrenfest contributed important work to thermodynamics and quantum mechanics (a.o. adiabatic invariants, and the Ehrenfest theorem). Broda describes not only his scientific research but also his interaction and relation to other famous physicist of his time, like Erwin Schrödinger, Albert Einstein and others. (nowak)

El Paso Paul Kayser

Energy Technology Data Exchange (ETDEWEB)

1975-09-01

The El Paso Paul Kayser, the world's largest LNG carrier, demonstrates not only the sophistication and skills of French shipbuilding technology but also the financial perils of the LNG game. Ordered along with 2 sister ships to transport LNG from Algeria to the US, the ship must now await the start-up of the new Kikda LNG plant, which has been delayed for an estimated 18 months. The Paul Kayser has a cargo capacity of 4.4 million cu ft, measures 922 ft overall, and has a deadweight of some 59,000 tons. The tanks were constructed according to the Gaz Transport technique using a double hull with Invar membranes. Labor involved with construction of the LNG tanks is estimated at 580,000 man-hr.

Evolución en niños con falla intestinal en un hospital de referencia en Medellín, Colombia

Directory of Open Access Journals (Sweden)

M.M. Contreras-Ramírez

2016-01-01

Conclusiones: El manejo médico de los pacientes con falla intestinal es complejo. El soporte nutricional y la monitorización continua son de vital importancia y la morbimortalidad a largo plazo depende del reconocimiento y manejo precoz de las complicaciones asociadas.

El papel de los principios en las fallas de los regímenes internacionales: el Fondo Monetario Internacional en la crisis económica argentina de 2001

OpenAIRE

De la Cuesta Zuluaga, Luisa

2015-01-01

Este trabajo de grado busca analizar el papel que juegan los principios en las fallas del Régimen Internacional de Pagos a la hora de responder a situaciones de crisis, específicamente, en la actuación del Fondo Monetario Internacional durante la crisis económica argentina de 2001. El Régimen, atado al cumplimiento de sus principios, actuó de manera tal que produjo unas fallas que terminaron exacerbando la crisis. Mediante el análisis de fuentes primarias y secundarias, y con métodos...

Paul Krugman : (presque un Nobel de géographie Paul Krugman: A Nobel Prize in geography?

Directory of Open Access Journals (Sweden)

Olivier Walther

2011-09-01

Full Text Available Paul Krugman a reçu le Prix Nobel d’économie pour son analyse des modèles du commerce mondial et de la localisation de l’activité économique. Voilà une nouvelle qui devrait réjouir certains géographes.Paul Krugman recently won Nobel Economics Prize for his work on trade patterns and location of economic activities. This sounds like good news for (some geographers.

Consideraciones nutricionales en el paciente con falla cardíaca crónica

Directory of Open Access Journals (Sweden)

Mario A. Hernández, MD

2012-11-01

Full Text Available La insuficiencia cardíaca congestiva es un síndrome caracterizado por reducción del gasto cardíaco, aumento de las presiones de llenado ventricular y activación neuroendocrina, que lleva a un proceso de fibrosis y apoptosis de la célula cardíaca. Afecta alrededor de 23 millones de personas en el mundo y confiere un pésimo pronóstico una vez se diagnostica. Desde el punto de vista fisiopatológico, la relación entre citocinas pro-inflamatorias, activación neuro-hormonal y alteraciones gastrointestinales conduce a un estado denominado caquexia cardíaca, determinado por pérdida acelerada de peso, fatiga, reducción de la fuerza muscular, anorexia y disminución de la calidad de vida; este proceso es capaz de deteriorar aún más el pronóstico vital de estos pacientes. En las últimas dos décadas, se han realizado avances en el tratamiento farmacológico y eléctrico de la falla cardíaca; sin embargo los estudios en el campo no farmacológico son pocos, en especial en el aspecto nutricional, y así mismo son escasas las recomendaciones de las guías internacionales acerca del tema. En estudios pequeños, una aproximación nutricional ha demostrado impactar de manera positiva la calidad de vida y tolerancia al ejercicio, si bien se requieren grandes estudios para determinar la viabilidad de este abordaje en pacientes con falla cardíaca.

Paul S Follansbee

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Paul S Follansbee. Articles written in Resonance – Journal of Science Education. Volume 11 Issue 6 June 2006 pp 8-25 General Article. Dr Smith goes to Los Alamos - Cyril Stanley Smith, Plutonium Metallurgy, and the Manhattan Project · Srivilliputhur G ...

Earth-Mars Telecommunications and Information Management System (TIMS): Antenna Visibility Determination, Network Simulation, and Management Models

Science.gov (United States)

Odubiyi, Jide; Kocur, David; Pino, Nino; Chu, Don

1996-01-01

This report presents the results of our research on Earth-Mars Telecommunications and Information Management System (TIMS) network modeling and unattended network operations. The primary focus of our research is to investigate the feasibility of the TIMS architecture, which links the Earth-based Mars Operations Control Center, Science Data Processing Facility, Mars Network Management Center, and the Deep Space Network of antennae to the relay satellites and other communication network elements based in the Mars region. The investigation was enhanced by developing Build 3 of the TIMS network modeling and simulation model. The results of several 'what-if' scenarios are reported along with reports on upgraded antenna visibility determination software and unattended network management prototype.

Blocking Tim-3 or/and PD-1 reverses dysfunction of tumor-infiltrating lymphocytes in HBV-related hepatocellular carcinoma.

Science.gov (United States)

Liu, Furong; Zeng, Gucheng; Zhou, Shaotang; He, Xiaoshun; Sun, Nianfeng; Zhu, Xiaofeng; Hu, Anbin

2018-03-22

The immunosuppression of tumor-infiltrating lymphocytes (TILs) is associated with rapid progression of hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). T cell Ig- and mucin-domain-containing molecule-3 (Tim-3) and programmed cell death 1 (PD-1) are important inhibitory molecules expressed on the surface of T cells, but their roles in the function of TILs in HBV-HCC are poorly understood. We aimed to study the roles of these two markers in HBV-HCC. Ninety patients with pathologically confirmed HBV-associated HCC were enrolled in our study. Blood samples, paired fresh tumor tissues and adjacent tissues were collected, and isolating peripheral blood mononuclear cells, TILs and adjacent-infiltrating lymphocytes were isolated from these samples. The patients were followed-up to allow survival analysis. Tim-3 or/and PD-1 was up-regulated expressed on CD4 + and CD8 + TILs in HBV-HCC patients and a higher proportion of TILs expressed PD-1 alone. Tim-3 + and PD-1 + TILs greatly decreased secretion of IFN-γ and TNF-α. Expression of Tim-3 and PD-1 on TILs negatively correlated with disease-free survival of HCC patients. Direct blockade of Tim-3 and PD-1 in vitro significantly enhanced TILs proliferation and secretion of IFN-γ and TNF-α. Expression of Tim-3 and/or PD-1 on TILs impairs their function and correlates negatively with disease-free survival in HBV-HCC. Direct blockade of Tim-3 and PD-1 restores anti-tumor effects of TILs, which suggests a potential target for novel immunotherapy in HBV-HCC. Copyright © 2018 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

Transcurrencia a lo largo de la Falla Sierra de Varas (Sistema de fallas de la Cordillera de Domeyko, norte de Chile Strike-slip along the Sierra de Varas Fault (Cordillera de Domeyko Fault-System, northern Chile

Directory of Open Access Journals (Sweden)

Hans Niemeyer

2009-01-01

Full Text Available El Sistema de Fallas de la Cordillera de Domeyko, de rumbo esencialmente norte-sur, es paralelo a la fosa chileno-peruana en el norte de Chile. Se analizaron los desplazamientos en el rumbo y en la vertical de una de sus fallas maestras: la Falla Sierra de Varas (FS V. Ésta se estudió en el segmento entre Aguada del Hornito y Aguada del Cerro Alto de Varas, sobre la base del desplazamiento en el rumbo de dos porciones de la unidad de Granitoides paleozoicos con idéntica petrografía, estructura interna y edad. Se determinó una separación sinistral horizontal de 15,6±1 km con una componente vertical de 4,9±0,1 km, lo cual implica un rechazo neto sinistral-inverso de 16,4±1 km. El alzamiento vertical está de acuerdo con el espesor estratigráfico erosionado del bloque oriental. Se investigó, además, la dinámica y cinemática de la FS V mediante el análisis de mesofallas asociadas a sus desplazamientos. Se determinó así un sistema estructural sinistral-inverso, que tuvo lugar durante el Eoceno medio tardío. Un segundo sistema estructural dextral, con desplazamiento de 0,6 km se sobrepuso sobre el anterior y ocurrió con posterioridad al Mioceno. Los desplazamientos simultáneos, tanto en el rumbo como según fallas inversas, dados por la existencia de una 'flor inversa en el segmento estudiado, indican que éste fue afectado primeramente por una transpresión. El desplazamiento sinistral demostrado paralaFSVy su cambio de rumbo hacia el SE, inmediatamente al sur de Aguada de Alto de Varas, son compatibles con la vergencia hacia el oeste de pliegues y fallas inversas asociadas del cinturón plegado y corrido de El Profeta, el cual también habría resultado de la transpresión.The north-south trending Cordillera de Domeyko Fault System in northern Chile considered herein is parallel to the Peru-Chile trench. The displacement history of the Sierra de Varas Fault, a master fault of the mentioned system, was examined in detall in the

Obituary: Paul Barr, 1955-2005

Science.gov (United States)

Parmar, Arvind

2007-12-01

Paul Barr, an extragalactic astronomer and spacecraft mission planner, died on 19 October 2005 at his home in Noordwijk, the Netherlands, at the age of 50. Although his scientific interests ranged from AGN to X-ray binaries, he will perhaps best be remembered for his mission planning skills on EXOSAT, ISO, and Integral. Many hundreds of observers have benefited from his ability to juggle seemingly impossible observing constraints and arrive at the optimum observing program. A rare talent. Barr was born in Sunderland, England, on 28 July 1995. After attending Saint Aidans Grammar School, where his father was the headmaster, he obtained his Bachelors Degree in astronomy from the University of London (June 1976) before moving to the Mullard Space Science Laboratory. There he obtained his Doctorate in X-ray astronomy in February 1980, using data from the Ariel V and Copernicus satellites. After a Post-Doctoral position at London University, where he did research into ultra-violet emission from AGN and X-ray binaries using IUE, Paul joined ESA in 1983. He worked on a wide range of missions including EXOSAT, ISO, and Integral. These observatories spanned the wavelength range from the Infra-red to the gamma-ray, giving insight into Paul's flexibility and ability to contribute in many areas. On ISO, Paul oversaw the scientific development and use of the very successful observation scheduling system — this topic became his specialty. As ISO operations became routine, he took up the challenge of space-borne gamma-ray astronomy and moved in 1997 to Integral where he worked in the Science Operation Centre (ISOC), at ESTEC in the Netherlands, as senior mission planner. He worked with the gamma-ray imager (IBIS) instrument team to ensure that operations of their instrument were properly supported by ESA and supported preparations of announcements of opportunity. In early 2005 the ISOC moved to Europe's Space Astronomy Centre (ESAC) just outside Madrid, Spain. Paul, however

Determinación de parámetros de fuga para fallas longitudinales, en conexiones domiciliarias y en uniones de tuberías en PVC

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Carolina González Barreto

2006-11-01

Full Text Available Las fugas en tuberías y accesorios se relacionan con fugas en orificios. Sin embargo, cada tipo de fuga presenta una ecuación potencial en la cual varían los exponentes y los coeficientes de descarga, según el tipo de falla. También se conoce que el caudal de fuga generalmente está relacionado con el área de la falla; pero, muchas veces no es posible determinar este componente geométrico, razón por la cual la ecuación para el cálculo del caudal de fuga debe relacionarse con variables conocidas en la práctica como el diámetro de las tuberías o las longitudes de cada falla, objetivo de esta investigación./ In general, the pipes and fittings leaks are analyzed like an orifice leak. However, each kind of failure has a particular equation with variable discharge coefficient and exponent. The leak discharge is related with the failure area, but many times it is not possible to calculate this component. Hence, the leak equation must be related with known variables like the pipe diameter or characteristic length of a failure.

Matriz de falla de los motores de inducciónBig Rotating Induction Machines Failure Matrix

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Santiago A Dorrbercker Drake

2011-02-01

Full Text Available La matriz de falla es una novedosa herramienta creada que constituye el único modo para la aplicacióndel  diagnóstico  integral  y  tomar  las  decisiones  adecuadas  en  las  instalaciones  industriales  y  suequipamiento. En el presente trabajo se muestra el camino seguido para la obtención de la matriz defallas correspondiente a los motores de inducción de gran potencia (MIGP.  Los resultados obtenidosestán soportados en un diagrama de Ishikawa caracterizado por 11 causas principales, 31 subcausas y36 motivos de falla.  Los resultados del presente trabajo constituyen el punto a partir del cual se obtienela matriz de ensayos de diagnóstico para los MIGP  The matrix of failures is a new tool created.  It means the only way to take the proper decision andapplication of integral diagnosis in industrial utilities and equipments. This paper presents the process toobtaining the matrix of failures of big induction rotating machines. In this case results are supported by anishikawa diagram characterized by 11 main causes, 31 sub-causes and 36 failure roots causes.  Resultsare the starting point to define the matrix of diagnosis test.

Illusoorne autentsus / Toomas Paul

Index Scriptorium Estoniae

Paul, Toomas, 1939-

2000-01-01

Arvustus: Taylor, Charles. Autentsuse eetika / inglise k. tlk. Märt Väljataga. Tallinn : Hortus Litterarum, 2000. (Avatud Eesti raamat). Ilmunud ka kogumikus: Paul, Toomas. Kirik keset küla. Tartu : Ilmamaa, 2003, lk. 311-317

Paul Rodgersi filter Kohilas

Index Scriptorium Estoniae

2000-01-01

28. I Kohila keskkoolis kohaspetsiifiline skulptuur ja performance "Filter". Kooli 130. aastapäeva tähistava ettevõtmise eesotsas oli skulptor Paul Rodgers ja kaks viimase klassi noormeest ئ Marko Heinmäe, Hendrik Karm.

Paul and Africa?

African Journals Online (AJOL)

Test

2011-06-07

Jun 7, 2011 ... The relationship between Saint Paul and the continent of Africa has never been a significant point of ... It consists of a constructive dialogue between a biblical original culture, .... John Walter Gregory to a continuous geological crack. (valley) of ...... As Stanley E. Porter concludes in his study on 2 Corinthians.

Advances in the research line of diagnosing of faults in fossil fuel power plants; Avances en la linea de investigacion de diagnostico de fallas en centrales termoelectricas

Energy Technology Data Exchange (ETDEWEB)

Ruz H, Jose A [Universidad Autonoma del Carmen, Campeche (Mexico); Sanchez C, Edgar N [Centro de Investigacion y Estudios Avanzados del Instituto Politecnico Nacional, Mexico, D.F. (Mexico); Suarez Cerda, Dionisio A; Quintero R, Agustin [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)

2006-07-01

This article deals with a research in progress searching to take care of the faults that occur with greatest frequency in the fossil fuel power plants of Mexico with the aid of tools of computational intelligence such as the neuronal networks and the fuzzy logic, for the online recognition of the dynamic behavior patterns of variable groups. What this research looks for is the development of individual systems, in relation to the computational intelligence techniques that continuously supervise the functioning of the unit and inform the operator of the eventual faults in the understanding that on time attention to the faults will result in a minimum cost. The advantages of these diagnosis mechanisms are established in comparison to alternative diagnosis methods, such as their associative memory useful to store fault patterns. [Spanish] Se trata de una investigacion en progreso que busca atender las fallas que ocurren con mayor frecuencia en las unidades termoelectricas de Mexico con la ayuda de herramientas de inteligencia computacional como las redes neuronales y la logica difusa, para el reconocimiento en linea de patrones de comportamiento dinamico de grupos de variables. Lo que esta investigacion busca es desarrollar sendos sistemas, en relacion a las tecnicas de inteligencia computacional, que supervisen continuamente el funcionamiento de la unidad e informen al operador de fallas eventuales, en el entendido que la oportuna atencion a fallas redituara en un costo minimo. Las ventajas de estos mecanismos de diagnostico se establecen en comparacion a metodos de diagnostico alternativos, como su memoria asociativa util para almacenar patrones de falla.

THE APOSTLE PAUL: THEOLOGIAN-MISSIONARY AND PASTOR-THEOLOGIAN. TOWARDS A DEEPER UNDERSTANDING OF SAINT PAUL

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Eckhart Schnabel

2013-04-01

Full Text Available This Article is an attempt to shed light on a few texts of the acts of the Apostles and of the epistles which are viewed as sources documenting the life and activity of Saint Paul. The author attempts to settle a number of questions regarding the authenticity of sources illustrating the life of Saint Paul. Similar questions are often raised by those who write and publish guides and textbooks for the teaching of the Pauline corpus. The author agrees with the overwhelming positive judgment of the academic world regarding the authenticity of the pastoral epistles, but at the same time he notes a number of objections to their authenticity proposed by the same forum: inconsistencies within the vocabulary of the texts themselves, their linguistic style, and their theological argumentation. The author concludes that these objections are inconclusive and the features enumerated by those who object constitute in reality only minor exceptions, inconsequential when taking into account the entire Pauline corpus. The author also examines the authenticity and historical accuracy of the account of the life of Saint Paul as given in the Acts of the Apostles. A few Biblicists claim that the account in Acts is merely legendary and is to be regarded as a type of early Christian folklore. The author disagrees with this opinion, backing up his position with the evidence that both the Acts of the Apostles and the Pastoral Epistles agree in historical detail and background. The author concludes with a further consideration regarding the correct method guiding biblical research on Saint Paul. He opines that such research must view the biblical texts in a correct historical perspective

Vasks: Cantabile per archi, Paul Mägi / Bernhard Uske

Index Scriptorium Estoniae

Uske, Bernhard

1994-01-01

Uuest heliplaadist "Vasks: Cantabile per archi; Botschaft: Musica Dolorosa, Sinfonie für Streicher (Stimmen). Latvijas Nicionalais Simfoniskais Orkestris, Latvijas Filharmonijas Kamerorkestris. Pauls Megi [Paul Mägi]", Tovijs Lifsics. Wergo CD 6220-2

A quantitative analysis of TIMS data obtained on the Learjet 23 at various altitudes

Science.gov (United States)

Jaggi, S.

1992-01-01

A series of Thermal Infrared Multispectral Scanner (TIMS) data acquisition flights were conducted on the NASA Learjet 23 at different altitudes over a test site. The objective was to monitor the performance of the TIMS (its estimation of the brightness temperatures of the ground scene) with increasing altitude. The results do not show any significant correlation between the brightness temperatures and the altitude. The analysis indicates that the estimation of the temperatures is a function of the accuracy of the atmospheric correction used for each altitude.

Analysis of Eocene depositional environments - Preliminary TM and TIMS results, Wind River Basin, Wyoming

Science.gov (United States)

Stucky, Richard K.; Krishtalka, Leonard; Redline, Andrew D.; Lang, Harold R.

1987-01-01

Both Landsat TM and aircraft Thermal IR Multispectral Scanner (TIMS) data have been used to map the lithofacies of the Wind River Basin's Eocene physical and biological environments. Preliminary analyses of these data have furnished maps of a fault contact boundary and a complex network of fluvial ribbon channel sandstones. The synoptic view thereby emerging for Eocene fluvial facies clarifies the relationships of ribbon channel sandstones to fossil-bearing overbank/floodplain facies and certain peleosols. The utility of TM and TIMS data is thereby demonstrated.

Methodology for the location diagnosis of electrical faults in electric power systems; Metodologia para el diagnostico de ubicacion de fallas en sistema electricos de potencia

Energy Technology Data Exchange (ETDEWEB)

Rosas Molina, Ricardo

2008-08-15

tareas mas afectada por esta situacion es la operacion de los sistemas electricos frente a la presencia de fallas, donde la primera labor a realizar por parte del personal de operacion de la red es la pronta ubicacion del lugar de falla dentro del sistema. En el presente trabajo se aborda el problema del diagnostico de ubicacion de fallas electricas en sistemas de potencia, desde la perspectiva de los operadores de los centros de control de energia de una empresa electrica. El objetivo de este trabajo de tesis es describir una metodologia de analisis de operacion de protecciones como base para el desarrollo de un sistema de diagnostico de ubicacion de fallas, que permita estimar los posibles lugares de falla dentro del sistema asi como una justificacion de la operacion de las protecciones ante un disturbio como apoyo a los operadores de los Centros de Control de Energia. La metodologia esta disenada para utilizar distintos tipos de informacion, discreta, continua y controles. Sin embargo, en el desarrollo de la presente etapa de la metodologia propuesta se hace uso exclusivamente de la informacion de tipo discreta de los estados de interruptores y operacion de relevadores, asi como de la conectividad de los elementos de la red. La metodologia de analisis consiste en determinar el grupo de elementos donde pudo haber ocurrido la falla, utilizando las zonas de cobertura de las protecciones asociadas a los interruptores operados. Posteriormente, estas alternativas de falla se ordenan en forma descendentes de posibilidad utilizando indices de clasificacion y analisis basados en logica difusa.

Onsite: A Residency with Tim Rollins/KOS. A Photo Essay.

Science.gov (United States)

Placky, Robert

2000-01-01

Presents a photo essay that visually narrates the workshop that took place in State College, Pennsylvania, from October 19-24, 1998 bringing together middle and high school students with Tim Rollins, who is a conceptual artist and educator, and Kids of Survival (KOS). (CMK)

α-Lactose Improves the Survival of Septic Mice by Blockade of TIM-3 Signaling to Prevent NKT Cell Apoptosis and Attenuate Cytokine Storm.

Science.gov (United States)

Yao, Yao; Deng, Hai; Li, Pingfei; Zhang, Jian; Zhang, Junbo; Wang, Deping; Li, Songbo; Luo, Yixing; Wei, Zhengping; Bi, Guoyu; Yang, Xiang-Ping; Tang, Zhao-Hui

2017-03-01

Sepsis is the leading cause of death among critically ill patients and natural killer T (NKT) cell activation is essential to induce inflammatory cytokine cascade in sepsis. However, little is known about what regulates the NKT cell function during sepsis. Herein, we showed that T-cell immunoglobulin and mucin domain 3 (Tim-3) expression in NKT cells is elevated in experimental mice during sepsis. Tim-3 expression was positively correlated with NKT cell activation and apoptosis. In sepsis, interleukin (IL)-12 secreted by dendritic cell exposure to lipopolysaccharide increased the expression of Tim-3 in NKT cells. Administration of α-lactose to block Tim-3 signaling pathway significantly improved the survival of septic mice, concomitant with reduced IL-12 production by dendritic cells, reduced Tim-3 expression, prevented NKT cell apoptosis, and attenuated production of inflammatory cytokines. Collectively, Tim-3 signaling in NKT cells plays a critical role in the immunopathogenesis of sepsis. Thus, α-lactose could be a promising immunomodulatory agent in the treatment of sepsis.

Paul Pinna avab Estonia Talveaias omanimelise baari / Christel Karits

Index Scriptorium Estoniae

Karits, Christel, 1966-

2006-01-01

Rahvusooper Estonia sajanda sünnipäeva puhul etendub 12. ja 13. septembril Estonia Talveaias lavastus "Paul Pinnat otsimas". Tekst on 95% osas Paul Pinna ja Karl August Hindrey sulest, dramatiseeris ja lavastas Heidi Sarapuu

Paul D. Sturkie: Avian cardiac physiologist.

Science.gov (United States)

Bello, Nicholas T; Cohick, Wendie S; McKeever, Kenneth H; Malinowski, Karyn

2018-06-01

Sturkie's Avian Physiology is a highly regarded textbook for the study of comparative poultry physiology. Less well known, however, is the contribution of Paul D. Sturkie (1909-2002) as a pioneer in the experimental physiology of avian species. His seminal research on the cardiovascular and hemodynamic controls of chickens and egg-laying hens had a notable impact on the poultry industry and breeding practices of farmers. The purpose of this article is to highlight the contributions and practical insights of Paul D. Sturkie to the field of poultry science.

Smart Mirrors for Photorefractive Control of Light with Tim Bunning, RX - Agile Filters Application

Science.gov (United States)

2016-11-08

AFRL-AFOSR-UK-TR-2017-0008 Smart Mirrors for photorefractive control of light with Tim Bunning, RX-- Agile filters application Luciano De Sio...DATE (DD-MM-YYYY)      10-02-2017 2. REPORT TYPE Final 3. DATES COVERED (From - To) 01 Feb 2014 to 31 Jan 2016 4. TITLE AND SUBTITLE Smart Mirrors for...photorefractive control of light with Tim Bunning, RX-- Agile filters application 5a.  CONTRACT NUMBER 5b.  GRANT NUMBER FA9550-14-1-0050 5c.  PROGRAM

Major Additions to the Linus Pauling Canon

Science.gov (United States)

Davenport, Derek A.

2002-08-01

The National Library of Medicine has also just posted a Web site on Linus Pauling in its Profiles of Science series. While by no means as rich as the various Oregon State University sites, it is well worth visiting. There are texts of various speeches (including his Nobel address), many downloadable photographs, correspondence (including a poignant letter to James Watson and Francis Crick concerning their "rival" structures for DNA), and much else besides. There is a certain irony in Linus Pauling being honored by the National Library of Medicine. Ever since his 1949 presidential address to the American Chemical Society, and perhaps earlier, Pauling had been at loggerheads, sometimes acrimoniously so, with the medical establishment. It is easy to imagine him somewhere in the timeless infinitude of the empyrean sporting his characteristic ear-to-ear grin.

Suppression of TIM-1 predicates clinical efficacy of sublingual immunotherapy for allergic rhinitis in children.

Science.gov (United States)

Lin, Zhibin; Zhou, Lifeng; Luo, Xi; Xia, Wentong; Chen, Dehua; Xu, Rui; Wang, Jie; Luo, Renzhong; Xu, Geng; Li, Huabin

2013-08-01

To evaluate the clinical efficacy of sublingual immunotherapy (SLIT) with house-dust mite (HDM) extract and to examine the change of biomarkers (TIM-1, IL-5 and IL-10) after 6-month SLIT in children with allergic rhinitis (AR). One hundred and sixteen HDM-sensitized children with persistent AR were enrolled to assess the clinical efficacy of SLIT by determining the individual nasal symptom score (INSS) and total nasal symptom scores (TNSS) after 6-month SLIT. Moreover, the mRNA expression of TIM-1, IL-5 and IL-10 in peripheral blood mononuclear cells (PBMCs) was examined in 16 well-controlled and 12 uncontrolled AR patients using quantitative reverse transcription polymerase chain reaction (qRT-PCR). After 6-month SLIT, both TNSS and INSS scores were significantly decreased compared with the baseline value (p < 0.01). The rates for well-controlled, partly controlled and uncontrolled children were 43.1%, 32.8% and 24.1%, respectively. Accordingly, the mRNA levels of TIM-1 and IL-5 decreased significantly and IL-10 mRNA level increased significantly compared with the baseline value in well-controlled children (p < 0.05). Our findings suggest SLIT with HDM extract is effective and safe for AR children and TIM-1 may be considered as an indicator for evaluating the clinical efficacy of SLIT. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Aquatic Plant Control Research Program. Proceedings, Annual Meeting, Aquatic Plant Control Research Program (23rd) Held in West Palm Beach, Florida on 14-17 November 1988

Science.gov (United States)

1989-06-01

85 CHEMICAL CONTROL TECHNOLOGY DEVELOPMENT .......... 91 Chemical Control Technology Development: Overview by Howard E. Westerdahl ...A, B, & C) Chemical Convod Technlo Development - H. Westerdah, WES, Presiding 8:00 a.m. Overview - Chemical Control Technology -H. Westerdahl , WES 8...Paul PO Box 631 1421 USPO & Custom House Vicksburg, MS 39181-0631 St. Paul, MN 55101-1479 Howard Westerdahl Tim Worley USAE Waterways Experiment Station

Diferencias de género en el tratamiento de la falla cardíaca

Directory of Open Access Journals (Sweden)

Clara Saldarriaga, MD

2014-01-01

Conclusión: para la población estudiada se encontró que existen diferencias entre ambos sexos tanto en las variables demográficas como clínicas. A pesar de presentar mayores comorbilidades, las mujeres con falla cardiaca reciben con menor frecuencia terapias como los betabloqueadores y el cardiodesfibrilador implantable que han demostrado disminuir la mortalidad. Es necesario ampliar el conocimiento de las diferencias de género mediante la creación de un registro multicéntrico latinoamericano que permita incidir en la toma de decisiones clínicas propias para la región.

HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications.

Directory of Open Access Journals (Sweden)

Lishomwa C Ndhlovu

2011-04-01

Full Text Available The T cell immunoglobulin mucin 3 (Tim-3 receptor is highly expressed on HIV-1-specific T cells, rendering them partially "exhausted" and unable to contribute to the effective immune mediated control of viral replication. To elucidate novel mechanisms contributing to the HTLV-1 neurological complex and its classic neurological presentation called HAM/TSP (HTLV-1 associated myelopathy/tropical spastic paraparesis, we investigated the expression of the Tim-3 receptor on CD8(+ T cells from a cohort of HTLV-1 seropositive asymptomatic and symptomatic patients. Patients diagnosed with HAM/TSP down-regulated Tim-3 expression on both CD8(+ and CD4(+ T cells compared to asymptomatic patients and HTLV-1 seronegative controls. HTLV-1 Tax-specific, HLA-A*02 restricted CD8(+ T cells among HAM/TSP individuals expressed markedly lower levels of Tim-3. We observed Tax expressing cells in both Tim-3(+ and Tim-3(- fractions. Taken together, these data indicate that there is a systematic downregulation of Tim-3 levels on T cells in HTLV-1 infection, sustaining a profoundly highly active population of potentially pathogenic T cells that may allow for the development of HTLV-1 complications.

Correlación vibroacústica: detección cognitiva e identificación de fallas. // Vibroacoustic correlation: Failure identification and cognoscitive detection

Directory of Open Access Journals (Sweden)

F. Miyara

2000-03-01

Full Text Available Se presenta una metodología para la investigación diagnóstica de fallas en máquinas industriales mediante un correladorvibroacústico, dispositivo que permite comparar automáticamente las frecuencias de una señal acústica y una vibratoria. Seconjuga así la habilidad humana para la detección de ruidos anómalos con la identificación objetiva de su procedencia.Palabras claves Acústica, ruido, vibraciones, correlación, fallas, identificación_____________________________________________________________________________AbstractA methodology for the diagnosis investigation of failure in industrial machines by means of a vibroacustic corelator ispresented, device that allow to compare the frecuencies of an acoustic signal and a vibratory one automatically.In this waythe human ability for the detection of anomalous noises is conjugated with the objective identification of their origin.Key words: Acoustic, Noise, Vibrations, Correlation, Failure Identification.

Sismotectónica de la falla de Alhama de Murcia, implicaciones sismogenéticas del terremoto de Lorca de junio-1977 (Mb: 4,2

Directory of Open Access Journals (Sweden)

Martínez-Díaz, J. J.

1999-12-01

Full Text Available A seismotectonic study of the oblique slip (strike-slip-reverse Alhama de Murcia Fault (FAM is presented. The spatial and temporal distribution of historical and instrumental seismicity around the fault is analyzed. The Lorca (1977, Mb 4.2 seismic sequence is interpreted in order to explain the extensional focal mechanism of the mainshock, under a compressional stress field. A model in which local extension occurs in the hanging wall, due to reverse movement of Alhama de Murcia Fault, is proposed to explain the earthquake. The hanging wall suffers a lateral extension due to free lateral space increase and/or flexion The dynamic link of FAM activity with small normal faults, located inside the hanging wall, may produce earthquakes with Mb ≻ 4.0. In that way, seismic risk assessment studies must to be into account the dynamic relations of second order active faults with the major faults, that are the true kinematic engine triggering activity on them.En este trabajo se presenta el estudio sismotectónico de la falla oblicua (inversodireccional de Alhama de Murcia y su entorno. Se analiza la distribución espacial y temporal de la sismicidad histórica e instrumental en el entorno de la falla y se reinterpreta la génesis de la serie sísmica de Lorca ocurrida en junio de 1977 (Mb: 4,2, que se explica desde un punto de vista tectónico, relacionando su mecanismo de foco de tipo extensional, con la estructura neotectónica de la zona epicentral. Se propone un modelo para la génesis de este evento relacionado con el levantamiento y plegamiento de la Sierra de las Estancias asociado a la actividad inverso-direccional de la FAM. En el bloque levantado se pueden producir dos efectos que explican un tensor local extensional: ganancia de espacio lateral en el bloque levantado por la falla, y procesos de flexión asociados a la componente inversa. La conexión dinámica entre la actividad inverso-direccional de la FAM y la actividad normal de las

Globaalne Paul Goble : " Lähituleviku suhtes olen pessimist" / Paul A. Goble ; interv. Teet Korsten

Index Scriptorium Estoniae

Goble, Paul Alan, 1949-

2004-01-01

Ilmunud ka: Severnoje Poberezhje, 18. sept. 2004, lk. 5. Kõrgetes USA valitsusametites teeninud sovetoloog Paul Goble, kes asus alaliselt elama Tartusse, räägib sidemetest Eestiga, huvist sovetoloogia vastu, endast. Vt. samas: 13 küsimust

Was Paul among the contemplatives?

Directory of Open Access Journals (Sweden)

James Panaggio

2016-09-01

Full Text Available This article offers a critique of the contemporary Contemplative Tradition’s view of spiritual transformation from the lens of the universally accepted letters of Paul. The article argues that contemporary contemplatives, especially Dallas Willard and Richard Foster, differ from Paul in three principle areas. Firstly, whereas Paul’s concept of transformation is based largely on objective realities, representatives of the Contemplative Tradition tend to focus on subjective realities. Secondly, contemporary contemplatives view transformation as coming as one imitates the life of Christ, his daily disciplines and activities, whereas Paul’s view centres on the death of Christ as foundational to the Christian’s identity and thus vital to the way they live out their faith. Finally, the cornerstone of the contemporary Contemplative Tradition’s view of spiritual transformation is the belief that the essential means by which transformation takes place is engagement in the spiritual disciplines. It is argued that many of the activities that are denominated as ‘spiritual disciplines’ are not in fact ‘transformative’ activities, and thus do not fit the category of spiritual disciplines. Furthermore, this study insists that Paul seldom links the practice of the disciplines with the means of transformation, offering instead five examples of specific means of transformation that flow out of Paul’s accepted letters.

Paul Krugman: välisvaluuta külge klammerdumine pole jätkusuutlik / Paul Krugman

Index Scriptorium Estoniae

Krugman, Paul, 1953-

2009-01-01

Valik 2008. aasta Nobeli majanduspreemia laureaadi Paul Krugmani vastuseid New Yorgi välisajakirjanike pressikeskuse briifingul "Kas depressioonimajandus tuleb tagasi?" esitatud Slovakkia, Lõuna-Aafrika, Austraalia ja Austria ajakirjanike küsimustele

Exhibition: Linus Pauling and the Twentieth Century

CERN Document Server

2003-01-01

On April 28 the exhibit Linus Pauling and the Twentieth Century organised by UNIDIR (United Nations Institute for Disarmament Research) and SGI (Soka Gakkai International) as well as with the contributions of CERN and the University of Geneva, opened at the United Nations Office of Geneva. Linus Pauling is the only person to date to have won two unshared Nobel Prizes: Chemistry in 1954 and Peace in 1962. The first was awarded for his landmark research on the nature of the chemical bond and its application in understanding the structure of complex substances. The second one acknowledged his courageous protest against atmospheric nuclear testing and his championship of international peace. The exhibit, for audience of all ages, traces seven decades of Linus Pauling's life and influence on the 20th century. Before starting its European tour at the UNESCO headquarters in Paris, the exhibit opened in 1998 in San Francisco and then travelled within the United-States and to Japan with an attendance of more than one...

Exhibition: Linus Pauling and the Twentieth Century

CERN Document Server

2003-01-01

On April 28 the exhibit Linus Pauling and the Twentieth Century organised by UNIDIR (United Nations Institute for Disarmament Research) and SGI (Soka Gakkai International) as well as with the contributions of CERN and the University of Geneva, opens at the United Nations Office of Geneva. Linus Pauling is the only person to date to have won two unshared Nobel Prizes: Chemistry in 1954 and Peace in 1962. The first was awarded for his landmark research on the nature of the chemical bond and its application in understanding the structure of complex substances. The second one acknowledged his courageous protest against atmospheric nuclear testing and his championship of international peace. The exhibit, for all ages' audiences, traces seven decades of Linus Pauling's life and influence on the 20th century. Before starting its European tour at the UNESCO headquarters in Paris, the exhibit opened in 1998 in San Francisco and then travelled within the United-States and to Japan with an attendance of more than one m...

Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway.

LENUS (Irish Health Repository)

Cao, Wei

2011-06-01

Emerging experimental data suggest an important role for the T-cell immunoglobulin mucin 1 (Tim-1):Tim-4 pathway in autoimmune and alloimmune responses in vivo. Using a Tim-4 ectodomain human IgG Fc fusion protein we studied the role of Tim-4 in T-cell activation, signalling and differentiation responses in vitro. We demonstrate that Tim-4Fc can inhibit naive and pre-activated T-cell activation, proliferation and cytokine secretion via a Tim-1-independent pathway. Tim-4 contains immunoglobulin variable (IgV) and mucin domains; to identify which domain accounts for the inhibitory effect novel Tim-4 fusion proteins containing either the IgV or mucin domain were generated. We demonstrate that both IgV and mucin domains are required for the inhibitory effects and that they are mediated at least in part by inhibition of extracellular signal-regulated kinase pathway activity. Given the emerging interest in the role of the Tim family in T helper type 17 (Th17) cells, which play an important role in autoimmune disease and transplantation tolerance, our data show that Tim-4Fc can prevent polarization of CD4(+) T cells to the Th17 phenotype. Collectively, our results highlight an inhibitory role for Tim-4Fc in vitro, which we propose is mediated by a receptor other than Tim-1. In addition, this study provides new insights into the role of Tim-4Fc in regulating Th17 immune responses and may open a new avenue for autoimmune therapy.

Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway

Science.gov (United States)

Cao, Wei; Ryan, Michelle; Buckley, Deirdre; O'Connor, Rosemary; Clarkson, Michael R

2011-01-01

Emerging experimental data suggest an important role for the T-cell immunoglobulin mucin 1 (Tim-1):Tim-4 pathway in autoimmune and alloimmune responses in vivo. Using a Tim-4 ectodomain human IgG Fc fusion protein we studied the role of Tim-4 in T-cell activation, signalling and differentiation responses in vitro. We demonstrate that Tim-4Fc can inhibit naive and pre-activated T-cell activation, proliferation and cytokine secretion via a Tim-1-independent pathway. Tim-4 contains immunoglobulin variable (IgV) and mucin domains; to identify which domain accounts for the inhibitory effect novel Tim-4 fusion proteins containing either the IgV or mucin domain were generated. We demonstrate that both IgV and mucin domains are required for the inhibitory effects and that they are mediated at least in part by inhibition of extracellular signal-regulated kinase pathway activity. Given the emerging interest in the role of the Tim family in T helper type 17 (Th17) cells, which play an important role in autoimmune disease and transplantation tolerance, our data show that Tim-4Fc can prevent polarization of CD4+ T cells to the Th17 phenotype. Collectively, our results highlight an inhibitory role for Tim-4Fc in vitro, which we propose is mediated by a receptor other than Tim-1. In addition, this study provides new insights into the role of Tim-4Fc in regulating Th17 immune responses and may open a new avenue for autoimmune therapy. PMID:21463297

Hermeneutics in identity formation: Paul's use of Genesis in ...

African Journals Online (AJOL)

Paul's hermeneutics, in dealing with the scriptures and traditions of Israel and his concern for a specific identity for the communities he interacted with, require attention for the reciprocal, interrelationship between hermeneutics and identity in his letters. Paul's quotations from and allusions to the scriptures of Israel but also ...

Influencia de un bloque rígido en un sistema de fallas de rumbo: modelamiento análogo Influence of a rigid block in a strike-slip fault system: analogue modelling

Directory of Open Access Journals (Sweden)

Thierry Nalpas

2011-01-01

Full Text Available En este trabajo se presenta un estudio de modelamiento análogo sobre la naturaleza, geometría y cinemática de la deformación a lo largo de fallas de rumbo dada la presencia de un bloque rígido en su trayectoria de deformación. Los modelos análogos están apropiadamente escalados considerando las características reológicas de los materiales que se desean contrastar en la deformación. Dos grandes parámetros fueron probados: la configuración del bloque rígido, variando su forma y tamaño, y el monto del desplazamiento. Los resultados experimentales muestran el desarrollo de rotaciones, fallas y pliegues como producto de la presencia de un bloque rígido en la trayectoria de falla. Los diversos casos geométricos probados pueden ser empleados para su comparación con sistemas de fallas de rumbo en los cuales existen diferencias litológicas de comportamiento reológico diferencial, como por ejemplo el caso del 'Núcleo rígido de Limón Verde' al sur de Chuquicamata, ubicado en la trayectoria del sistema de fallas de Domeyko.This work addresses the kinematic effects of a rigid block in strike-slip systems by using analogue models. The experiments (size, behaviour of materials were scaled down in order to represent deformation of the tested rheologic contrast conditions in deformation. Two main parameters were tested: the configuration of the rigid block, changing its form and size, and the amount of displacement. The experiments evidenced the development of rotations, faults and folds along the fault trajectory, as resulting from the presence of the rigid block during the deformation. Testing of diverse geometric situations may be used for comparison to strike-slip fault systems in which different lithologies and rheologic behaviour exist, for example, presence of the 'Limón Verde rigid core' along the Domeyko fault system, just south of Chuquicamata.

Hmong Political Involvement in St. Paul, Minnesota and Fresno, California

Directory of Open Access Journals (Sweden)

Yang Lor

2010-01-01

Full Text Available Over the past several years, Hmong in the United States have gained prominence for their increasing involvement in politics. Most of the attention has understandably focused on Fresno, California and St. Paul, Minnesota, home to the two largest Hmong populations in this country. While the Hmong communities in both cities are similar in size and have made significant political progress as evidenced by the election of Hmong candidates, the Hmong community in St. Paul has made greater inroads in the political realm. In addition to the elections of two Hmong candidates to the Minnesota State Legislature and two to the St. Paul School Board, the Hmong community in St. Paul has been able to engage local and state governments in Minnesotato address issues that affect the Hmong community. Through interviews, census data, and newspaper coverage of political campaigns, I show that Hmong in St. Paul have achieved greaterrepresentation in local and state governments and received greater support from government officials than Hmong in Fresno because Minnesota offers a social, economic, and politicalcontext that is favorable to fostering Hmong political involvement. Compared to Hmong in Fresno, Hmong in St. Paul have higher levels of socioeconomic resources and are more visible given their large size relative to other minority groups. They live in a region with consistently high levels of political participation and have political candidates who devote resources to mobilizing the Hmong community. Moreover, the Hmong vote has been critical to the success of Hmong candidates in St. Paul, an indication of the increasing political clout of the Hmong community there and a major reason why politicians in Minnesota are more willing to respond toissues that affect the Hmong community. Overall, this study highlights the importance of local and regional context in understanding the political incorporation of immigrants.

On social justice: Comparing Paul with Plato, Aristotle and the Stoics

Directory of Open Access Journals (Sweden)

Johan Strijdom

2007-05-01

Full Text Available n “In search of Paul” (2004 Crossan and Reed argue that Paul’s vision and program were essentially in continuity with Jesus’: both opposed, be it in Galilean villages or Roman cities, an unjust imperial system by means of an alternative project of egalitarian, distributive justice. Although Crossan elsewhere demonstrates the deep roots of this concern in the Jewish tradition, he tends to downplay the importance of Greek contributions in this regard. The purpose of this essay will be to offer, in constant dialogue with Crossan (and Reed, a more refined comparison of social justice in Paul on the one hand and Plato, Aristotle and the Stoics on the other. If Paul tried to establish egalitarian and sharing Christian communities under the Roman empire, how do this vision and program compare and contrast with Plato's hierarchical but communal concept of justice, Aristotle’s distributive notion according to merit, and most importantly the Stoics’ argument of “oikeiosis” (i.e., other-concern by concentrical familiarization with the other? Imagine, say Crossan and Reed (CR hereafter in their recent book on Paul, the following dialogue between ourselves and Paul: Do you think, Paul, that all men are created equal and endowed by their Creator with certain inalienable rights? I am not speaking about all men, but about all Christians. But do you think, Paul, that all people should be Christians? Yes, of course,. And do you think, Paul, that all Christians should be equal with one another?Yes, of course. Then do you think, Paul, that it is God’s will for all people to be equal with one another? Well, let me think about that one for a while and, in the meantime, you think about equality in Christ. (CR 2004:234

Fault diagnosis in the steam generator of a thermoelectric power plant using Petri networks; Diagnostico de fallas en el generador de vapor de una termoelectrica usando redes de Petri

Energy Technology Data Exchange (ETDEWEB)

Suarez Cerda, Dionisio A; Sanchez Lopez, Alfredo [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico); Martinez Prieto, Jose E; Garcia Beltran, Carlos D. [Centro Nacional de Investigacion y Desarrollo Tecnologico, Cuernavaca, Morelos (Mexico)

2007-07-01

With time, all physical systems show modifications in the dynamics of its operation. This can be attributed to different causes, for example, wear by friction, deterioration by overheating or natural aging, among others. These changes evolve gradually, until getting to become faults related to the reliability, availability, efficiency, safety and continuity of the operation, which seriously affect the performance indexes of the system. In this article a scheme of fault diagnosis is shown, applied to the steam generator of a thermoelectric power unit, based on techniques of modeling of dynamic systems by means of Petri networks. Against other methods, the scheme offers greater easiness for its implementation, rapidity of adaptation before changes of operation zone and good robustness. A way to reduce the effect of faults in a production system consists of two steps. The first one is to diagnose the fault as soon as it occurs and subsequently put into practice remedial actions. The concept of fault diagnosis is related to the first stage and encompasses the detection, as well as the location of this one. That is to say, besides determining that a fault is present, it is known in what component it has happened. In base to the former, it is clear that a diagnosis system requires supervising the variables that characterize the behavior of the faults, in order to detect them at the moment in which they occur and informing it to the operator. With this information, the operator will be able to realize the necessary remedial actions so that the plant continues operating as long as possible. [Spanish] Con el tiempo, todo sistema fisico manifiesta modificaciones en la dinamica de su funcionamiento. Esto puede atribuirse a diferentes causas, como por ejemplo, desgaste por friccion, deterioro por sobrecalentamiento o envejecimiento natural, entre otras. Estos cambios evolucionan gradualmente, hasta llegar a convertirse en fallas relacionadas con la confiabilidad

Recognition of faults patterns in electric generators using artificial neurons networks; Reconocimiento de patrones de fallas en generadores electricos empleando redes neuronales artificiales

Energy Technology Data Exchange (ETDEWEB)

Rocha Sanchez, Martha Alicia

1999-03-01

This work present the development of a reprocessing method to reduce the information of the original data and to maintain the essential information of the data that enter the reduction process. The obtaining of these data is performed with the aid of the ICM ++ (ICMsystems), from which vectors or n-uplos of elements are obtained. This investigation allowed to analyze an evaluation of the paradigms of artificial neural networks, with the intention of detecting which of these paradigms would evolve better with the problem of fault diagnosis in electric generators. From this a prototype system was developed called diagnosis of faults in electrical generators, which automatically will recognize faults in electrical generators by means of the interpretation of the recording of partial discharges. [Spanish] El presente trabajo presenta el desarrollo de un metodo de reprocesamiento para reducir informacion de los datos originales y mantener la informacion esencial de los datos que entran al proceso de reduccion. La obtencion de estos datos se realiza con la ayuda del ICM ++ (ICMsystems), de los cuales se obtienen vectores o n-uplos de elementos. Esta investigacion permitio analizar una evaluacion de los paradigmas de redes neuronales artificiales, con el objeto de detectar cual de estos paradigmas se desempenaria mejor con el problema de diagnostico de fallas en generadores electricos. A partir de esto se desarrollo un sistema prototipo llamado diagnostico de fallas en generadores electricos, el cual automaticamente reconocera fallas en los generadores electricos mediante la interpretacion de registro de descargas parciales.

Significado tectónico y migración de fluidos hidrotermales en una red de fallas y vetas de un Dúplex de rumbo: un ejemplo del Sistema de Falla de Atacama Tectonic significance and hydrothermal fluid migration within a strike-slip duplex fault-vein network: an example from the Atacama Fault System

Directory of Open Access Journals (Sweden)

Viviana Olivares

2010-07-01

Full Text Available El Dúplex Caleta Coloso es una estructura de rumbo desarrollada durante la deformación frágil del Sistema de Falla de Atacama (SFA en el Cretácico Temprano. En su interior hay un sistema de vetas hidrotermales que documentan la naturaleza de la relación entre el transporte de fluidos y el desarrollo del dúplex. El sistema de vetas de orientación dominante NW se localiza en la roca de caja, adyacentes a las zonas de falla. Según su mineralogía dominante hay vetas de clorita, epidota-cuarzo y calcita-limonita, y según las relaciones de corte o su estructura interna, se definieron vetas tempranas (clorita, intermedias (epidota-cuarzo y tardías (calcita-limonitas. Algunas vetas muestran cristales perpendiculares u oblicuos a sus paredes (vetas de extensión y de extensión oblicua o fibras minerales orientadas paralelas a las estrías de las fallas (vetas-fallas. Estas últimas tienen indicadores cinemáticos compatibles con las fallas, evidenciando que fueron sincinemáticas con el desarrollo del dúplex. Según su microestructura, ellas se habrían formado en fracturas abiertas llenas de fluidos, bajo condiciones de presión inferior a la hidrostática, lo cual indicaría que la precipitación mineral ocurrió por caídas abruptas de la presión en una corteza somera (The Caleta Coloso Duplex is a brittle strike-slip structure developed along the Atacama Fault System during the Early Cretaceous. A hydrothermal vein system existing within the duplex documents the nature of the link between fluid transport and progressive structural development. The dominantly NW-striking vein system occurs near or at the damage zone of the duplex fault zones. Veins can be classified according to their composition and crosscutting relationships into early chlorite veins, intermediate epidotic-quartz veins and late calcite-limonite veins. Some of them exhibit minerals with their long axes oriented orthogonally or obliquely with respect to the vein walls

Pauling, Prof. Linus Carl

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1949 Honorary. Pauling, Prof. Linus Carl Nobel Laureate (Chemistry) - 1954; Peace - 1962. Date of birth: 28 February 1901. Date of death: 19 August 1994. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th ...

Magnetohydrodynamics and the earth's core selected works by Paul Roberts

CERN Document Server

Soward, Andrew M

2003-01-01

Paul Roberts'' research contributions are remarkable in their diversity, depth and international appeal. Papers from the Paul Roberts'' Anniversary meeting at the University of Exeter are presented in this volume. Topics include geomagnetism and dynamos, fluid mechanics and MHD, superfluidity, mixed phase regions, mean field electrodynamics and the Earth''s inner core. An incisive commentary of the papers puts the work of Paul Roberts into historical context. Magnetohydrodynamics and the Earth''s Core provides a valuable source of reference for graduates and researchers working in this area of geoscience.

Servicing the first web server - Tim Berners-Lee's NeXT

CERN Multimedia

unknown, Association aBCM

2009-01-01

In August 2009 a team from the Association aBCM in Lausanne came to CERN to give the world's first web server a health check under the watchful eye of web pioneer Robert Cailliau. They took an image of the hard drive at this time, copies of which were given to Robert Cailliau and Tim Berners-Lee.

Kritik Nalar Hermeneutika Paul Ricoeur

Directory of Open Access Journals (Sweden)

Daden Robi Rahman

2016-03-01

Full Text Available Hermeneutics was born and developed in the West, specifically in response to the theological problem of Christianity, and always claimed to be an effective solution to the interpretation of Scripture. With existence of various schools, hermeneutics has also various shades and resulted different interpretations. Such as Schleiermacher, followed by Wilhelm Dilthey and Emilio Betti as initiators of hermeneutics methodology. Martin Heidegger and Gadamer followed with their ontological hermeneutics, and continued by Habermas with his critical hermeneutics. After that, the critical ontological hermeneutics initiated by either Paul Ricoeur, or Rudolf Bultman with his theological hermeneutics, and Derrida with his deconstructive hermeneutics. Among those schools, the writers interested in reviewing the hermeneutics of Paul Ricoeur which represents a distinctive theory of interpretation. His idea considered to be a bridge of the fierce debate between methodological traditions and philosophical traditions represented by Emilio Betti and Hans Georg Gadamer. The thought of Ricoeur was also claimed as a mediator between the positions of the romantic tradition of Schleiermacher and Dilthey with philosophy hermeneutic by Martin Heidegger. In another side, he was placed as a combination between the two great philosophical tradition, that’s German phenomenology and France structuralism. Furthermore, the thought of Ricoeur is a revision to the thought of Dilthey about explanation (erklären and understanding (verstehen. Through this paper, the writer will attempt to unravel the thought of Paul Ricoeur, and in the end, will clearly known the position of Ricoeur among other hermeneutics initiators.

The TimBel synchronization board for time resolved experiments at synchrotron SOLEIL

International Nuclear Information System (INIS)

Ricaud, J.P.; Betinelli-Deck, P.; Bisou, J.; Elattaoui, X.; Laulhe, C.; Monteiro, P.; Nadolski, L.S.; Renaud, G.; Ravy, S.; Silly, M.; Sirotti, F.

2012-01-01

Time resolved experiments are one of the major services that synchrotrons can provide to scientists. The short, high frequency and regular flashes of synchrotron light are a fantastic tool to study the evolution of phenomena over time. To carry out time resolved experiments, beamlines need to synchronize their devices with these flashes of light with a jitter shorter than the pulse duration. For that purpose, Synchrotron SOLEIL has developed the TimBeL (Timing Beamlines) board fully interfaced to TANGO framework. The TimBeL system is a compact PCI board. It is made of a mother with one daughter board. All functions are performed inside a FPGA (Field Programmable Gate Array) implemented on the mother board. A PLX Technology chip is used to communicate with the compact PCI crate. To enable experiments to remain always synchronous with the same bunch of electrons, the storage ring clock (CLK-SR) and the radio frequency clock (CLK-RF) are provided by the machine to beamlines. These clocks are used inside the FPGA as main clocks for state machines. Because the jitter is too large on the FPGA outputs, a daughter board with a jitter cleaner has been added to the system. This board also provides delay lines for compensating time offsets by 10 ps steps. This paper presents the main features required by time resolved experiments and how we achieved our goals with the TimBeL board

Meandering Musings by Linus Pauling: "American Scientists and the Spirit of the Frontier".

Science.gov (United States)

Bause, George S

2016-04-01

Hoping to raise funds in 1975 for his namesake institute, Linus Pauling submitted to Esquire magazine a 32-page handwritten manuscript, "American Scientists and the Spirit of the Frontier." Angered when his submission for publication was declined, Pauling eventually gifted the original manuscript in 1986 to his friend, Linus Pauling Institute fundraiser Stephen Maddox, who would sell it in 2004 to the Wood Library-Museum of Anesthesiology. Published accurately here for the first time, the manuscript captures not only Pauling's sweeping metaphor of scientists as frontiersmen but also the creative process by which Pauling formulated his hydrate microcrystal theory of general anesthesia. Copyright © 2015 Elsevier Inc. All rights reserved.

Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry

OpenAIRE

Rhein, Bethany A.; Brouillette, Rachel B.; Schaack, Grace A.; Chiorini, John A.; Maury, Wendy

2016-01-01

Phosphatidylserine (PtdSer) receptors that are responsible for the clearance of dying cells have recently been found to mediate enveloped virus entry. Ebola virus (EBOV), a member of the Filoviridae family of viruses, utilizes PtdSer receptors for entry into target cells. The PtdSer receptors human and murine T-cell immunoglobulin mucin (TIM) domain proteins TIM-1 and TIM-4 mediate filovirus entry by binding to PtdSer on the virion surface via a conserved PtdSer binding pocket within the amin...

U-series dating using thermal ionisation mass spectrometry (TIMS)

International Nuclear Information System (INIS)

McCulloch, M.T.

1999-01-01

U-series dating is based on the decay of the two long-lived isotopes 238 U(τ 1/2 =4.47 x 10 9 years) and 235 U (τ 1/2 0.7 x 10 9 years). 238 U and its intermediate daughter isotopes 234 U (τ 1/2 = 245.4 ka) and 230 Th (τ 1/2 = 75.4 ka) have been the main focus of recently developed mass spectrometric techniques (Edwards et al., 1987) while the other less frequently used decay chain is based on the decay 235 U to 231 Pa (τ 1/2 = 32.8 ka). Both the 238 U and 235 U decay chains terminate at the stable isotopes 206 Pb and 207 Pb respectively. Thermal ionization mass spectrometry (TIMS) has a number of inherent advantages, mainly the ability to measure isotopic ratios at high precision on relatively small samples. In spite of these now obvious advantages, it is only since the mid-1980's when Chen et al., (1986) made the first precise measurements of 234 U and 232 Th in seawater followed by Edwards et al., (1987) who made combined 234 U- 230 Th measurements, was the full potential of mass spectrometric methods first realised. Several examples are given to illustrate various aspects of TIMS U-series

ECMO respiratorio como opción terapéutica en falla respiratoria refractaria en la edad pediátrica

Directory of Open Access Journals (Sweden)

Otto M. González-Pardo

2016-11-01

La ECMO es una terapia que desde el año 1985 ha mostrado tener una sobrevida del 53% en este grupo, llegando a niveles del 63% en los últimos años, particularmente, si la etiología es el virus sincitial respiratorio. Se reportan dos casos de pacientes lactantes menores con falla respiratoria refractaria en quienes se decidió iniciar la ECMO logrando la sobrevida de ambos.

Technological tendencies for the development and implementation of fault tolerant active controls in combined cycle power plants; Tendencias tecnologicas para el desarrollo e implantacion de controles activos tolerantes a fallas en centrales de ciclo combinado

Energy Technology Data Exchange (ETDEWEB)

Sanchez P, Marino; Verde R, Cristina [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)

2006-07-01

This document proposes a methodology that reunites support tools for the operator of a Combined Cycle Generating Power Station allowing him to identify and to classify gas turbine faults, it also reunites some tools for the generation of action advices in the decision making on the operation maneuvers necessary to counteract the effects caused by faults. We are talking about a system implemented in a power station with the reconfiguration of processes and fault arrangement capacities. For this purpose, the line of exhibition delimits first the existing knowledge on automatic control and operations supervision systems in a CCPP and immediately emphasizes the cracks of the system to let pass to the fault tolerant active control system that will detect faults of the gas and steam turbo-generators of a Combined Cycle Generating Power Plant. [Spanish] El presente documento propone una metodologia que reuna herramientas de ayuda al operador de una Central Generadora de Electricidad de Ciclo Combinado para permitirle la identificacion y clasificacion de fallas en las turbinas de gas, asi como herramientas para la generacion de consejos de accion en la toma de decisiones sobre las maniobras de operacion necesarias para contrarrestar los efectos provocados por fallas. Se trata principalmente de un sistema implantado en una central con las capacidades de re-configuracion de procesos y acomodo de fallas. Para esto, la linea de exposicion delimita primero el conocimiento existente sobre sistemas automaticos de control y supervision de operacion en una CGCC y resalta enseguida las grietas del sistema para darle paso al sistema de control activo tolerante a fallas que detectara fallas de los turbogeneradores de gas y vapor de una Central Generadora de Electricidad de Ciclo Combinado.

Insights into the fold organization of TIM barrel from interaction energy based structure networks.

Science.gov (United States)

Vijayabaskar, M S; Vishveshwara, Saraswathi

2012-01-01

There are many well-known examples of proteins with low sequence similarity, adopting the same structural fold. This aspect of sequence-structure relationship has been extensively studied both experimentally and theoretically, however with limited success. Most of the studies consider remote homology or "sequence conservation" as the basis for their understanding. Recently "interaction energy" based network formalism (Protein Energy Networks (PENs)) was developed to understand the determinants of protein structures. In this paper we have used these PENs to investigate the common non-covalent interactions and their collective features which stabilize the TIM barrel fold. We have also developed a method of aligning PENs in order to understand the spatial conservation of interactions in the fold. We have identified key common interactions responsible for the conservation of the TIM fold, despite high sequence dissimilarity. For instance, the central beta barrel of the TIM fold is stabilized by long-range high energy electrostatic interactions and low-energy contiguous vdW interactions in certain families. The other interfaces like the helix-sheet or the helix-helix seem to be devoid of any high energy conserved interactions. Conserved interactions in the loop regions around the catalytic site of the TIM fold have also been identified, pointing out their significance in both structural and functional evolution. Based on these investigations, we have developed a novel network based phylogenetic analysis for remote homologues, which can perform better than sequence based phylogeny. Such an analysis is more meaningful from both structural and functional evolutionary perspective. We believe that the information obtained through the "interaction conservation" viewpoint and the subsequently developed method of structure network alignment, can shed new light in the fields of fold organization and de novo computational protein design.

Enabling Lead Free Interconnects in DoD Weapon Systems

Science.gov (United States)

2017-09-28

STATEMENT Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT An enhanced multi-pronged technology transfer approach will be designed to communicate...the needs of the weapon system program managers. Examples of risk will be given and information will be provided on where to access more detailed...Paul Zutter, Janelle Fowler, Holley Wingard, Jon Ahlbin, Charles Peltier, – Air Force • Paul Steiner, Tim Kalt, Gary Dowdy – NAVSEA • Mick Miller

Consumerism, Activism, Intrinsic Motivation, and Balance: An Interview with Tim Kasser

Science.gov (United States)

Keeley, Jared

2010-01-01

A year after receiving his PhD in psychology from the University of Rochester, Tim Kasser accepted a position at Knox College, in Galesburg, Illinois, where he is currently professor of psychology. He regularly teaches psychology classes on personality, clinical and abnormal psychology, dreaming, and research methods, as well as an…

Activation-Induced TIM-4 Expression Identifies Differential Responsiveness of Intestinal CD103+ CD11b+ Dendritic Cells to a Mucosal Adjuvant.

Directory of Open Access Journals (Sweden)

Kerry L Hilligan

Full Text Available Macrophage and dendritic cell (DC populations residing in the intestinal lamina propria (LP are highly heterogeneous and have disparate yet collaborative roles in the promotion of adaptive immune responses towards intestinal antigen. Under steady-state conditions, macrophages are efficient at acquiring antigen but are non-migratory. In comparison, intestinal DC are inefficient at antigen uptake but migrate to the mesenteric lymph nodes (mLN where they present antigen to T cells. Whether such distinction in the roles of DC and macrophages in the uptake and transport of antigen is maintained under immunostimulatory conditions is less clear. Here we show that the scavenger and phosphatidylserine receptor T cell Immunoglobulin and Mucin (TIM-4 is expressed by the majority of LP macrophages at steady-state, whereas DC are TIM-4 negative. Oral treatment with the mucosal adjuvant cholera toxin (CT induces expression of TIM-4 on a proportion of CD103+ CD11b+ DC in the LP. TIM-4+ DC selectively express high levels of co-stimulatory molecules after CT treatment and are detected in the mLN a short time after appearing in the LP. Importantly, intestinal macrophages and DC expressing TIM-4 are more efficient than their TIM-4 negative counterparts at taking up apoptotic cells and soluble antigen ex vivo. Taken together, our results show that CT induces phenotypic changes to migratory intestinal DC that may impact their ability to take up local antigens and in turn promote the priming of mucosal immunity.

Paul Feyerabend: Science and the Anarchist.

Science.gov (United States)

Science, 1979

1979-01-01

Presents comments on the arguments of Paul Feyerabend toward progression science. The positions held by this philosopher of science are given with accompanying remarks from other philosophers and historians. (SA)

Eestis meenutati Paul Kerest / Kalev Vilgats

Index Scriptorium Estoniae

Vilgats, Kalev

2011-01-01

Paul Kerese 95. sünniaastapäeva puhul viibisid Tallinnas male eksmaailmameister Anatoli Karpov ja teised malemaailma tipud. President Toomas Hendrik Ilves kohtus male suurkujudega Kadriorus 6. jaan. 2011

DIVERSITAS TIM MANAJEMEN PUNCAK, KEKOMPREHENSIFAN PENGAMBILAN KEPUTUSAN, INTEGRASI SOSIAL DAN KINERJA PERUSAHAAN: STUDI PADA BANK PERKREDITAN RAKYAT

Directory of Open Access Journals (Sweden)

Arief Prima Johan

2014-07-01

Full Text Available AbstractAlthough research on diversity management team had been widely conducted, previous research defined diversity in many different ways and many studies focused their research on top management team of big companies and big industries. This study examined the influence of several type of diversity of top management team on decision-making comprehensiveness and social integration, and tests these last two variables on performance. Using data Rural Banks (banking industry, the results showed that several variables of diversity of top management team affect decision-making comprehensiveness and social integration. The study also confirmed that the company's performance is affected by decision-making comprehensiveness and social integration.Keywords:Team Management, Diversity, Decision-Making Comprehensiveness, Social Integration, Performance.AbstrakMeskipun penelitian mengenai diversitas tim manajemen sudah banyak dilakukan, tetapi penelitian yang lalu mendefinisikan diversitas dengan cara yang berbeda-beda dan banyak berfokus pada tim manajemen puncak perusahaan besar dan industri besar. Penelitian ini menguji pengaruh variable-variabel diversitas tim manajemen puncak perusahaan terhadap kekomprehensifan pengambilan keputusan dan integrasi sosial, serta menguji dua variable terakhir ini pada kinerja. Dengan menggunakan data Bank Perkreditan Rakyat (industri perbankan, hasil penelitian memperlihatkan bahwa beberapa variable diversitas manajemen puncak mempengaruhi kekomprehensifan pengambilan keputusan dan integrasi sosial.Penelitian juga mengkonfirmasi bahwa kinerja perusahaan dipengaruhi oleh kekomprehensifan pengambilan keputusan dan integrasi sosial.Kata Kunci:Tim Manajemen Puncak, Diversitas, Kekomprehensifan, Pengambilan Keputusan, Integrasi Sosial, Kinerja Perusahaan.

DETECCIÓN Y AISLAMIENTO ROBUSTO DE FALLAS MEDIANTE OBSERVADORES CON ENTRADAS DESCONOCIDAS

Directory of Open Access Journals (Sweden)

JUAN ANZUREZ MARÍN

2009-01-01

Full Text Available En el presente artículo se muestra una metodología de diseño de observadores con entradas desconocidas para la solución del problema de Detección de Fallas. La técnica propuesta se basa principalmente en la observación de señales de error conocidas como residuos, las cuales se obtienen mediante la diferencia entre la salida actual del sistema y la salida estimada. Un observador con entradas desconocidas tiene la particularidad de que su vector de error de estimación tiende a cero asintóticamente, sin considerar la presencia de las entradas desconocidas o perturbaciones en el sistema. El algoritmo de detección se aplica satisfactoriamente en un sistema hidráulico de nivel de líquido tanto en simulación como en tiempo real.

Methodology for locating faults in the Eastern distribution system PDVSA, Punta de Mata and Furrial Divisions; Metodologia para la localizacion de fallas en el sistema de distribucion de PDVSA Oriente, Divisiones Punta de Mata y Furrial

Energy Technology Data Exchange (ETDEWEB)

Martinez, F [Universidad Nacional Experimental Politecnica, Antonio Jose de Sucre, Guayana, Bolivar (Venezuela)]. E-mail: fco_martinez@outlook.com; Vasquez, C [Petroleos de Venezuela S.A., Maturin, Monagas (Venezuela)]. E-mail: vasquezcp@pdvsa.com

2013-03-15

Fault location in distribution systems has received a lot of attention in recent years in order to increase the availability of electricity supply. Due to the characteristics of distribution networks, fault location is a complicated task, so methods have been developed based on the variation of current and voltage values measured at the source substation, in normal operating condition and under the occurrence of short circuits. This article presents the implementation in MATLAB of a fault location algorithm applied to distribution systems, based on graphical analysis of the fault reactance which is determined by the minimum value of the reactance, using serial impedance matrix and fault/prefault voltage and current metering. Developed Tool Accuracy was verified by comparing the results obtained through it with actual recorded event data (Multilin SR 760) and distance to a known failure point. Additionally the method was applied to an experimental case that was compared with network fault simulation using ETAP Software. For both evaluated cases, the absolute error did not exceed 7%. [Spanish] La localizacion de fallas en sistemas de distribucion ha recibido atencion en los ultimos anos con el fin de aumentar la disponibilidad del suministro de energia electrica. Debido a las caracteristicas propias de las redes de distribucion, la ubicacion de fallas resulta una tarea complicada, por lo que se han desarrollado metodos basados en la variacion de los valores de corriente y voltaje medidos en la subestacion fuente, en condicion normal de operacion y ante la ocurrencia de cortocircuitos. Este articulo presenta la implementacion en MATLAB de un algoritmo de localizacion de fallas en sistemas de distribucion que se fundamenta en el analisis grafico de la reactancia de falla, mediante el cual se determina el minimo valor de la reactancia, utilizando la matriz de impedancia serie y la medicion de los voltajes y corrientes de prefalla y falla. Se verifico la precision de la

Reframing Paul's sibling language in light of Jewish epistolary forms ...

African Journals Online (AJOL)

However, Jewish dimensions (particularly ethnic dimensions) of Paul's sibling language still remain unexplored in current scholarship. Furthermore, scholars have not drawn much attention to how Jewish letter writers use sibling terms in their letters. This article offers a new interpretation on Paul's sibling language in light of ...

Space Solar Power Exploratory Research and Technology (SERT) Technical Interchange Meeting 2 (SERT TIM 2)

Science.gov (United States)

Howell, Joe; Sanders, Clark W.

2000-01-01

The University of Alabama in Huntsville's (UAH) Propulsion Research Center hosted the Space Solar Power Exploratory Research & Technology (SERT) Technical Interchange Meeting TIM) 2 in Huntsville, Alabama December 7-10. 1999 with 126 people in attendance. The SERT program includes both competitively procured activities. which are being implemented through a portfolio of focused R&D investments--with the maximum leveraging of existing resources inside and outside NASA. and guided by these system studies. Axel Roth. Director of the Flight Projects Directorate NASA MSFC, welcomed the SERT TIM 2 participants and challenged them to develop the necessary technologies and demonstrations that will lead to Space Solar Power (SSP) International implementation. Joe Howell, NASA MSFC, reiterated the SERT TIM 2 objectives: 1) Refining and modeling systems approaches for the utilization of SSP concepts and technologies, ranging, from the near-term e.g. for space science, exploration and commercial space applications to the far-term (e. g. SSP for terrestrial markets), including systems concepts, technology, infrastructure (i.g., transportation), and economics. 2) Conducting technology research, development and demonstration activities to produce "proof- of-concept" validation of critical SSP elements for both the nearer and farther-term applications. 3) Initiating partnerships Nationality and Internationally that could be expanded, as appropriate, to pursue later SSP technology and applications (e.g., space science. colonization, etc.). Day one began with the NASA Centers presenting their SERT activities summary since SERT TIM 1 and wound up with a presentation by Masahiro Mori, NASDA titled "NASDA In-house Study for SSP". Demonstration for the Near-Term. Day two began with the SERT Systems Studies and Analysis reports resulting from NRA 8-23 followed by presentations of SERT Technology Demonstrations reports resulting from NRA 8-23. Day two closed with John Mankins presentation

Infrared spectroscopy for geologic interpretation of TIMS data

Science.gov (United States)

Bartholomew, Mary Jane

1986-01-01

The Portable Field Emission Spectrometer (PFES) was designed to collect meaningful spectra in the field under climatic, thermal, and sky conditions that approximate those at the time of the overflight. The specifications and procedures of PFES are discussed. Laboratory reflectance measurements of rocks and minerals were examined for the purpose of interpreting Thermal Infrared Multispectral Scanner (TIMS) data. The capability is currently being developed to perform direct laboratory measurement of the normal spectral radiance of Earth surface materials at low temperatures (20 to 30 C) at the Jet Propulsion Laboratory.

Up-regulated expression of Tim-3/Gal-9 at maternal-fetal interface in pregnant woman with recurrent spontaneous abortion.

Science.gov (United States)

Li, Jing; Li, Fan-fan; Zuo, Wei; Zhou, Yuan; Hao, Hai-yan; Dang, Jing; Jiang, Min; He, Meng-zhou; Deng, Dong-rui

2014-08-01

The relationship between T cell immunoglobulin domain and mucin domain protein 3 (Tim-3)/Galectin (Gal)-9 pathway and recurrent spontaneous abortion (RSA) was studied. Thirty-one pregnant women with RSA and 27 normal early gravidas were investigated to detect the levels of Tim-3 and Gal-9 in villi and deciduas by Western blotting. Meanwhile, the concentration of interleukin (IL)-4 and IL-12 in peripheral blood plasma was determined by ELISA in 25 healthy fertile non-pregnant controls, the normal early gravidas and pregnant women with RSA mentioned above, respectively. It was found that the relative expression levels of Tim-3 and Gal-9 in villi and deciduas were significantly increased in pregnant women with RSA as compared with those in the normal early gravidas. The concentration of IL-4 in peripheral blood plasma of pregnant women with RSA was lower than that of the normal early gravidas (Ppregnant controls (Ppregnant women with RSA was significantly higher than that of the normal early gravidas (Ppregnant controls (P<0.05). It was suggested that the overexpression of Tim-3/Gal-9 pathway may be related to the pathogenesis of RSA.

Geología de la zona de influencia de la falla otú en el distrito minero segovia-remedios

Directory of Open Access Journals (Sweden)

MILTON ÁLVAREZ GALINDEZ

2007-01-01

Full Text Available Se presenta la caracterización geológica y estructural de la zona de influencia de la falla Otú en jurisdicción del distrito minero Segovia-Remedios. Además, se proponen controles mecánicos para las mineralizaciones auríferas, que si bien son compatibles, en parte, con un modelo de depósitos de oro orogénico, dejan abiertas otras posibles interpretaciones

Analysis of the root cause of failure in 34.5 kV premolded terminal; Analisis de la causa raiz de falla en terminal premoldeada en 34.5 kV

Energy Technology Data Exchange (ETDEWEB)

Marroquin de Jesus, A; Olivares Ramirez, J. M [Universidad Tecnologica de San Juan del Rio, San Juan del Rio, Queretaro (Mexico)]. E-mails: amarroquind@utsjr.edu.mx; jmolivaresr@utsjr.edu.mx; Solis Gastelum, Adrian; Hernandez Cruz, Jose Rigoberto [Servicios Especiales Electricos, Santiago de Queretaro, Queretaro (Mexico)]. E-mails: seesel@axtel.net; seesel1@axtel.net

2013-03-15

A large number of faults in power cables are associated with improper installation of joints and terminations. In a joint improperly installed the presences of partial discharges or excessive heat generation occur over time the complete failure of the cable. However, there are cases that have nothing to do with a faulty installation, but with the operating conditions of the cables. In this paper we review the procedure to handle an emergency service to the failure of premolded terminals in medium voltage indoor type, root cause analyzes and makes recommendations for the maintenance of power lines. [Spanish] Un gran numero de fallas en cables alimentadores son asociadas con una mala instalacion de empalmes y terminales. En un empalme mal instalado la presencia de descargas parciales o generacion excesiva de calor producen con el tiempo la falla completa del cable. Sin embargo, tambien existen causas que no tienen que ver con una mala instalacion sino con las condiciones de operacion de los cables. En el presente trabajo se revisa el procedimiento para atender un servicio de emergencia ante la falla de terminales premoldeadas tipo interior en media tension, se analiza la causa raiz y se hacen recomendaciones en cuanto al mantenimiento de cables de energia.

Paul Bouchardy (1937 – 2012)

CERN Multimedia

2012-01-01

It is with great sorrow that we announce the sudden passing of our former colleague and friend, Paul Bouchardy, on Friday 17 February.   An outstanding travel agent, well-respected and active within his profession (he was in charge of apprenticeships for the Association of Geneva Travel Agencies - AGAV), Paul was director of the Carlson Wagonlit agency at CERN for many years. He knew the world like the back of his hand, and many people have benefited from his vast knowledge and expert tourist advice. Key figure in the Laboratory since the 1970’s, he retired in 2002 after 38 years with Carlson Wagonlit, including more than 30 years of on-site service to the CERN community. In these difficult days, our thoughts are with his wife and children and grandchildren, the family he cherished above all else and who accompanied him until embarking on his final journey. His friends and former colleagues at CERN

Neutron radiography at the Paul Scherrer Institute

International Nuclear Information System (INIS)

Pleinert, H.; Lehmann, E.; Hammer, J.

1994-01-01

Neutron radiography provides an efficient tool of measurement for many applications in fundamental research as well as in industrial non-destructive testing (NDT). A neutron radiography program has been initiated at the Paul Scherrer Institute and implemented since 1992. From the beginning of 1992 until the end of 1993, a neutron facility has been in operation at the SAPHIR research reactor. Several applications have been tested and programs on two main fields of application have been established, focusing on the study of porous materials, especially concrete and granitic rock. The investigations on concrete and other building materials are carried out in cooperation with the Swiss Federal Institute of Technology in Zurich. The experimental activities are currently carried out at the Atominstitute of the Austrian Universities in Vienna, in the framework of a cooperation program with the Atominstitute. The continuation of the activities on a new radiography facility at the spallation source SINQ is planned at the Paul Scherrer Institute. In the following an overview of the method, of the actual and potential applications of neutron radiography at the Paul Scherrer Institute is given. (author) 6 figs., 1 tab., 3 refs

Application of Circuit Simulation Method for Differential Modeling of TIM-2 Iron Uptake and Metabolism in Mouse Kidney Cells

Directory of Open Access Journals (Sweden)

Zhijian eXie

2013-06-01

Full Text Available Circuit simulation is a powerful methodology to generate differential mathematical models. Due to its highly accurate modelling capability, circuit simulation can be used to investigate interactions between the parts and processes of a cellular system. Circuit simulation has become a core technology for the field of electrical engineering, but its application in biology has not yet been fully realized. As a case study for evaluating the more advanced features of a circuit simulation tool called Advanced Design System (ADS, we collected and modeled laboratory data for iron metabolism in mouse kidney cells for a H ferritin (HFt receptor, T cell immunoglobulin and mucin domain-2 (TIM-2. The internal controlling parameters of TIM-2 associated iron metabolism were extracted and the ratios of iron movement among cellular compartments were quantified by ADS. The differential model processed by circuit simulation demonstrated a capability to identify variables and predict outcomes that could not be readily measured by in vitro experiments. For example, an initial rate of uptake of iron-loaded HFt was 2.17 pmol per million cells. TIM-2 binding probability with iron-loaded HFt was 16.6%. An average of 8.5 minutes was required for the complex of TIM-2 and iron-loaded HFt to form an endosome. The endosome containing HFt lasted roughly 2 hours. At the end of endocytosis, about 28% HFt remained intact and the rest was degraded. Iron released from degraded HFt was in the labile iron pool (LIP and stimulated the generation of endogenous HFt for new storage. Both experimental data and the model showed that TIM-2 was not involved in the process of iron export. The extracted internal controlling parameters successfully captured the complexity of TIM-2 pathway and the use of circuit simulation-based modeling across a wider range of cellular systems is the next step for validating the significance and utility of this method.

Plaadid / Tiiu Laks

Index Scriptorium Estoniae

Laks, Tiiu, 1984-

2007-01-01

Uutest heliplaatidest The Shins "Wincing The Night Away", A Am Kloot "BBC Radio 1Peel Sessions", Tim Finn "Imaginary Kingdom", Kling Klang "The Esthetik of destruction", "25 Avenue le bar plaza Athenee Paris", Paul Weller "Hit Parade"

Interview med professor Paul du Gay om bureaukratiets værdi

DEFF Research Database (Denmark)

Pors, Anja Svejgaard

2013-01-01

Paul du Gay er sociolog og globaliseringsprofessor ved Institut for Organisation på Copenhagen Business School. I hans forskning interesserer han sig blandt andet for bureaukratiet som styreform. Gennem årtier har bureaukratiet været genstand for omfattende kritik for dets langsommelighed......, inhumanitet og manglende fleksibilitet. Paul du Gay har taget til genmæle og forsvarer bureaukratiet som en styreform, der understøtter demokrati. I arbejdet med administration som praksis og faglighed har vi interviewet Paul du Gay om nogle af de centrale pointer i denne forskning. Samtalen kredser om...

Feto-maternal immune regulation by TIM-3/galectin-9 pathway and PD-1 molecule in mice at day 14.5 of pregnancy

DEFF Research Database (Denmark)

Meggyes, Matyas; Lajko, Adrienn; Palkovics, Tamas

2015-01-01

INTRODUCTION: Immunoregulation implies the activation of negative pathways leading to the modulation of specific immune responses. Co-inhibitory receptors (such as PD-1 and TIM-3) represent possible tools for this purpose. PD-1 and TIM-3 have been demonstrated to be present on immune cells...... suggesting general involvement in immunosuppression such as fetomaternal tolerance. The aim of our study was to investigate the expression pattern of PD-1, TIM-3, and its ligand Gal-9 on different immune cell subsets in the peripheral blood and at the fetomaternal interface in pregnant mice. METHODS: TIM-3...... and PD-1 expression by peripheral and decidual immune cells from pregnant BALB-c mice in 2 weeks of gestational age were measures by flow cytometry. Placental galectin-9 expression was determined by immunohistochemically and RT-PCR. RESULTS: Gal-9 was found to be present in the spongiotrophoblast layer...

La evaluación psicológica de las fallas en las competencias parentales en padres maltratadores

OpenAIRE

Febbraio, Andrés

2015-01-01

Este trabajo de investigación tuvo como objetivo analizar a través de nueve competencias parentales, si la falla en dichas funciones se relaciona con el maltrato de padres a hijos. Se utilizó una muestra de 62 casos de hombres y mujeres judicializados, a los cuales se les habían administrados cuatro técnicas proyectivas para su evaluación (Entrevista semidirigida, Test de las Dos Personas, Test de la Familia Kinética y Cuestionario Desiderativo). Para cada técnica o test se determinó un "indi...

Notes on Paul Kuimet / Pille Epner

Index Scriptorium Estoniae

Epner, Pille

2011-01-01

Fotograaf Paul Kuimetist, tema loomingust, Tallinnas Hobusepea galeriis toimunud isikunäitusest "In Vicinity" (2010), mis uuris valglinnastumist, kohaspetsiifilisest installatsioonist "Untitled" (2010) ja näitusest "Not Necessarily So" (koos Laura Tootsiga, 2010) Linzis

A multipurpose TIM-based optical telescope for Omega and the Trident laser facilities

International Nuclear Information System (INIS)

Oertel, J.A.; Murphy, T.J.; Berggren, R.R.

1998-01-01

The authors have recently designed and are building a telescope which acts as an imaging light collector relaying the image to an optical table for experiment dependent analysis and recording. The expected primary use of this instrument is a streaked optical pyrometer for witness plate measurements of Hohlraum drive temperature. The telescope is based on University of Rochester's Ten-Inch Manipulator (TIM) which allows compatibility between Omega, Trident, and the NIF lasers. The optics capture a f/7 cone of light, have a field of view of 6-mm, have a spatial resolution of 5 to 7-microm per line pair at the object plane, and are optimized for operation at 280-nm. The image is at a magnification of 11.7x, which is convenient for many experiments, but can be changed using additional optics that reside outside the TIM

Fault diagnosis in the steam turbo-generator of a Combined Cycle Power Plant; Diagnostico de fallas en el turbogenerador a vapor de una central de generacion de ciclo combinado

Energy Technology Data Exchange (ETDEWEB)

Flores Abad, Angel

2006-12-15

extra space and expenses implied in the use of repeated devices. The design of the system was carried out by using the structural analysis (SA) which is a tool based on graph theory and computer science. The SA allowed the analysis of monitorability, detectability and isolability properties of the process, besides it provides the computation sequence of non monitored (unknown) variables in order to obtain the analytical redundancy relations. To validate the fault diagnosis system, the detection and isolation algorithms were programmed in C language and integrated to the simulator software of a CCPP in LabWindows CVI. In order to provide a way to easily identify the existence of a fault, a graphic interface was developed, where the faulty component, sensor or actuator is indicated. [Spanish] Debido a la naturaleza fisica de sus componentes, todos los procesos tecnologicos son susceptibles de falla. Estas fallas afectan el funcionamiento del sistema, provocando desde una reduccion en su desempeno hasta cuantiosas perdidas economicas y en el peor de los casos desastres ambientales y humanos. La deteccion oportuna de la presencia de las fallas ayuda a tomar acciones correctivas y como consecuencia a reducir el dano potencial que estas ocasionan. Para realizar la tarea de deteccion de fallas, los procesos tecnologicos cuentan con sistemas de monitoreo y alarmas que se activan si algunas de las variables monitoreadas rebasa un umbral establecidos. El metodo presenta el inconveniente de que ante la presencia de una sola falla se pueden activar varias alarmas, lo que dificulta la tarea para localizar al elemento danado. Ademas, se basa en la redundancia fisica, que consiste en el uso de elementos repetidos para realizar una misma tarea. Las centrales de generacion de ciclo combinado (CGCC) son procesos de gran escala con alto grado de susceptibilidad a fallas, a causa de las condiciones estrictas en las que operan y del gran numero de componentes que contienen, incluyendo

Performance characteristics of a Bioassay method for plutonium using thermal ionisation mass spectrometry (TIMS)

Energy Technology Data Exchange (ETDEWEB)

Linauskas, S.H.; Elliot, N.L.; Paterson, L.M.; Totland, M.M

2003-01-01

Plutonium-in-urine analysis by radiochemical isolation of Pu followed by thermal ionisation mass spectrometry (TIMS) is capable of high sensitivity and precision measurements {sup 239}Pu and {sup 240}Pu. Bias and precision estimates for the TIMS bioassay program at Chalk River Laboratories easily met the ANSI N13.30 performance criteria standards with {sup 239}Pu results of 1.5% and 3.0%, respectively. Analytical blanks derived from water, artificial urine and true urine samples did not produce any statistically different results. During a four-year period of development and implementation of {sup 239}Pu measurements by TIMS, average sample blank values were reduced from 3.9 fg (9.0 {mu}Bq) to 0.57 fg (1.3 {mu}Bq). This reduction was achieved through rigorous application of clean-room handling techniques throughout sample processing. Blank data were found to follow a Iognormal distribution, and current detection limit parameters for L{sub c} and L{sub d} at the 95% significance levels are 0.85 fg {sup 239}Pu (2.0 {mu}Bq) and 1.3 fg {sup 239}Pu (3.0 {mu}Bq), respectively. Detection limits in this range are expected to be sufficient to identify intakes of Pu/Am mixtures at levels that are around one-twentieth of an ALl or better under routine monitoring situations for ICRP Type S and Type M inhalation solubility classes. (author)

Paul Dundes Wolfowitz. Aukus sokkidega pistrik nõelub mainet / Arko Olesk

Index Scriptorium Estoniae

Olesk, Arko, 1981-

2007-01-01

Maailmapanga president Paul Wolfowitz teatas pressikonverentsil, et soovib tööd jätkata. Paul Wolfowitzi karjäärist, päritolust, eraelust ja usalduse kaotamisest korruptsioonihõngulise loo pärast oma sõbratarile Shaha Ali Rizale palgatõusu nõudmisel

Dirac, Prof. Paul Adrien Maurice

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Dirac, Prof. Paul Adrien Maurice Nobel Laureate (Physics) - 1933. Date of birth: 8 August 1902. Date of death: 20 October 1984. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

Paul Henning Krogh on Soil Ecotoxicology

DEFF Research Database (Denmark)

Krogh, Paul Henning

2008-01-01

In a recent analysis of data from Essential Science Indicators SM from Thomson Reuters , Dr. Paul Henning Krogh was named a Rising Star in the field of Environment & Ecology. His current record in this field includes 48 papers cited a total of 410 times. Dr. Krogh is a Senior Scientist in the Dep......In a recent analysis of data from Essential Science Indicators SM from Thomson Reuters , Dr. Paul Henning Krogh was named a Rising Star in the field of Environment & Ecology. His current record in this field includes 48 papers cited a total of 410 times. Dr. Krogh is a Senior Scientist...... in the Department of Terrestrial Ecology at the National Environmental Research Institute, part of the University of Aarhus in Silkeborg, Denmark. This month, he talks with ScienceWatch.com correspondent Simon Mitton about his highly cited work. View Article...

Determination of La and Nd by thermal ionization mass spectrometry (TIMS) pre-separated by high performance liquid chromatography (HPLC)

International Nuclear Information System (INIS)

Jaison, P.G.; Raut, N.M.; Parab, A.R.; Khodade, P.S.; Govindan, R.; Aggarwal, S.K.

2003-01-01

Determination of La and Nd by TIMS is required for accurate determination of burn-up of nuclear fuels. During their thermal ionization mass spectrometric (TIMS) analysis, 138 Ce and 142 Ce show spectroscopic isobaric interferences at 138 La and 142 Nd, respectively. Hence, it is essential to remove Ce from La and Nd for their accurate isotopic composition determination. Reversed phase high performance liquid chromatography (HPLC) is a promising technique for rapid and effective separation

Cultura digital jovem: as TIMS invadem as periferias, e agora?

Directory of Open Access Journals (Sweden)

Márcia Gonçalves Nogueira

2014-08-01

Full Text Available Objective of this work is to present a literature review on Young and the Digital Cultural transformations caused by the dissemination of Information Technology and Communication Mobile and wireless (TIMS on the outskirts of the metropolitan area of Recife. To this end, we seek to identify how young periphery, high school students of a public school, they experience the Digital Culture in different social spaces; among them the school, scene of many tensions and generational conflicts and language as social and cultural use of these mobile devices. We highlight some theoretical approaches to the phenomenon of mobile communication and the concept of Digital Culture, adopted in this work. Proposing a reflection on the role of school in the current social context of constant cultural and linguistic transformations multimodality of the digital age. Finally, we present an exercise of looking on Youth Cultures, from different theoretical, to better understand the multiple transits covered by surveyed youth to express themselves and make sense of their audiovisual productions, mediated by TIMS. This theoretical argument was used in the dissertation in mathematics education and technology by one of the authors of this article. Therefore, we hope to contribute to further research on Digital Youth Culture in the context of the periphery.

Space Solar Power Technical Interchange Meeting 2: SSP TIM 2

Science.gov (United States)

Sanders, Jim; Hawk, Clark W.

1998-01-01

The 2nd Space Solar Power Technical Interchange Meeting (SSP TIM 2) was conducted September 21st through 24th with the first part consisting of a Plenary session. The summary results of this Plenary session are contained in part one of this report. The attendees were then organized into Working Breakout Sessions and Integrated Product Team (IPT) Sessions for the purpose of conducting in-depth discussions in specific topic areas and developing a consensus as to appropriate study plans and actions to be taken. The Second part covers the Plenary Summary Session, which contains the summary results of the Working Breakout Sessions and IPT Sessions. The appendix contains the list of attendees. The ob'jective was to provide an update for the study teams and develop plans for subsequent study activities. This SSP TIM 2 was initiated and the results reported electronically over the Internet. The International Space Station (ISS) could provide the following opportunities for conducting research and technology (R&T) which are applicable to SSP: (1) Automation and Robotics, (2) Advanced Power Generation, (3) Advanced Power Management & Distribution (PMAD), (4) Communications Systems and Networks, (5) Energy Storage, (6) In Space Propulsion (ISP), (7) Structural Dynamics and Control, and Assembly and (8) Wireless Power Transmission.

[Fatal diseases and "imaginary" suffering. "Hypochondria" and "consumption" in the correspondence between Jean Paul and Johann Bernhard Hermann, with a perspective on Jean Paul's literature and aesthetics].

Science.gov (United States)

Meier, Monika

2007-01-01

The German writerJean Paul (Johann Paul Friedrich Richter, 1763-1825) and his friendJohann Bernhard Hermann (1761-1790) became acquainted with the thoughts of late Enlightenment at the University of Leipzig. They particularly appreciated the anthropology of Ernst Platner, who taught philosophy and aesthetics as well as medicine. Their confidential correspondence contains reflections on their respective situation and well being. Both write about feeling ill and label their illness "hypochondria". In the course of the correspondence Jean Paul's understanding of hypochondria evolves from an illness of the entrails as he follows Hermann, who supports the modern concept of hypochondria as an illness of the nerves. Two important themes from this correspondence recur in Jean Paul's novels and tales: firstly, his way of expressing comfort is related to his aesthetics, and secondly, the satirical way of portraying at least certain aspects of illness as imaginary reappears in his first successful novel "The Invisible Lodge" (1793).

Jean-Paul Diss (1928-2012)

CERN Multimedia

2012-01-01

We were greatly saddened to learn of the sudden death of Dr Jean-Paul Diss at his home on 7 June 2012.   Jean-Paul studied medicine at the Strasbourg Faculty of Medicine and began his career as an occupational medical practitioner at the Mulhouse potash mines. He then came to CERN in 1965 to set up a Medical Service at the request of the then CERN Director-General, Professor Weisskopf. He was the first person to hold the position of Head of the Medical Service and he invested all his energies to provide the Organization with an occupational healthcare unit worthy of the name. As a pioneer of occupational medicine, he worked tirelessly to improve the working conditions of the members of the personnel and continued to be solicitous about the health of every member of the personnel until his retirement in 1993.  Over the past twenty years, he remained active within the CERN Pensioners Association, in particular as the pensioners’ representative on the CERN Health Insuran...

Project TIMS (Teaching Integrated Math/Science)

Science.gov (United States)

Edwards, Leo, Jr.

1993-01-01

The goal of this project is to increase the scientific knowledge and appreciation bases and skills of pre-service and in-service middle school teachers, so as to impact positively on teaching, learning, and student retention. This report lists the objectives and summarizes the progress thus far. Included is the working draft of the TIMS (Teaching Integrated Math/Science) curriculum outline. Seven of the eight instructional subject-oriented modules are also included. The modules include informative materials and corresponding questions and educational activities in a textbook format. The subjects included here are the universe and stars; the sun and its place in the universe; our solar system; astronomical instruments and scientific measurements; the moon and eclipses; the earth's atmosphere: its nature and composition; and the earth: directions, time, and seasons. The module not included regards winds and circulation.

Diagnóstico de motores eléctricos para la localización de fallas incipientes

OpenAIRE

Delgado Arredondo, Paulo Antonio

2017-01-01

En este trabajo se presenta la exploración de metodologías de diagnóstico basadas en el análisis de vibraciones y sonido, debido a que cada señal amplifica mejor la presencia de un tipo de avería, y que, frente a un motor con un funcionamiento sospechoso, resulta conveniente combinar la información de cada una de ellas. Una de las contribuciones de este trabajo es una nueva metodología de análisis para la detección de fallas en motores de inducción en estado estacionario. El diagnóstico de la...

77 FR 68149 - Karen Paul Holley, M.D.; Decision and Order

Science.gov (United States)

2012-11-15

... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 12-51] Karen Paul Holley, M.D... revoke the DEA Certificate of Registration (COR), Number BH8988339, of Karen Paul Holley, M.D....D., 74 FR 17528, 174529 (2009); John B. Freitas, D.O., 74 FR 17524, 17525 (2009); Roger A. Rodriguez...

Análisis Estructural de Fallas Geológicas y Potenciales Deslizamientos en Anconcito, Provincia de Santa Elena

OpenAIRE

Kervin Chunga

2015-01-01

El sector costero de Anconcito, localizado al suroeste de la provincia de Santa Elena, es afectado por fenómenos geológicosinducidos por la dinámica costera de la zona de estudio: (1) socavamiento de los acantilados causado por la dinámica de la erosión marina y posterior derrumbe de estratos rocosos, y (2) deslizamientos de estratos rocosos a través de planos lístricosde fallas geológicas de tipo normal con componentes de desplazamientos laterales dextrales. El análisis estructural permitió ...

Järgmise lainega võivad tulla meile Ühendriikide investorid / Tim Ferland ; interv. Margit Aedla

Index Scriptorium Estoniae

Ferland, Tim

2003-01-01

Eestis asuva Ameerika Kaubanduskoja (ACCE) president Tim Ferland analüüsib Eesti senist arengut, EL-iga liitumise mõju tulevasele majanduslikule arengule, Eesti ning USA majandus- ja kaubandussuhete olukorda

"Paul Revere's Ride": Awakening Abolitionists

Science.gov (United States)

Lepore, Jill

2011-01-01

Henry Wadsworth Longfellow used to be both the best-known poet in the English-speaking world and the most beloved, adored by the learned and the lowly alike, read by everyone from Nathaniel Hawthorne and Abraham Lincoln to John Ruskin and Queen Victoria--and, just as avidly, by the queen's servants. "Paul Revere's Ride" is Longfellow's best-known…

U-series dating using thermal ionisation mass spectrometry (TIMS)

Energy Technology Data Exchange (ETDEWEB)

McCulloch, M.T. [Australian National University, Canberra, ACT (Australia). Research School of Earth Science

1999-11-01

U-series dating is based on the decay of the two long-lived isotopes{sup 238}U({tau}{sub 1/2}=4.47 x 10{sup 9} years) and {sup 235}U ({tau}{sub 1/2} 0.7 x 10{sup 9} years). {sup 238}U and its intermediate daughter isotopes {sup 234}U ({tau}{sub 1/2} = 245.4 ka) and {sup 230}Th ({tau}{sub 1/2} = 75.4 ka) have been the main focus of recently developed mass spectrometric techniques (Edwards et al., 1987) while the other less frequently used decay chain is based on the decay {sup 235}U to {sup 231}Pa ({tau}{sub 1/2} = 32.8 ka). Both the {sup 238}U and {sup 235}U decay chains terminate at the stable isotopes {sup 206}Pb and {sup 207}Pb respectively. Thermal ionization mass spectrometry (TIMS) has a number of inherent advantages, mainly the ability to measure isotopic ratios at high precision on relatively small samples. In spite of these now obvious advantages, it is only since the mid-1980`s when Chen et al., (1986) made the first precise measurements of {sup 234}U and {sup 232}Th in seawater followed by Edwards et al., (1987) who made combined {sup 234}U-{sup 230}Th measurements, was the full potential of mass spectrometric methods first realised. Several examples are given to illustrate various aspects of TIMS U-series 9 refs., 3 figs.

“This is you”: Encountering Shakespeare with Tim Crouch

Directory of Open Access Journals (Sweden)

Sara Soncini

2017-11-01

Full Text Available This essay considers Tim Crouch's "I Shakespeare", a suite of monologue plays based on "The Tempest" ("I, Caliban", 2003, "A Midsummer Night's Dream" ("I, Peaseblossom", 2004, "Macbeth" ("I, Banquo", 2005, "Twelfth Night" ("I, Malvolio", 2010 and "Julius Caesar" ("I, Cinna (the poet", 2012. While originally designed for a young audience, Crouch's adaptations have been performed in a variety of theatrical contexts that have added new and probably unforeseen dimensions to their negotiations with Shakespeare. In my analysis I turn to the notion of mobility as a key analytical tool to elucidate the method, aims, as well as the broader cultural meaning of Tim Crouch's reworkings. In his hands, Shakespeare is mobilized as a powerful resource to activate spectators and emphasize their co-authorship in the process of theatre. Through a combination of textual strategies and performance methods, the monologues construct the identities of Shakespeare's characters as multiple and mutable and, in parallel, cast their addressees in fluid, often contradictory roles. My main line of argument is that the plays' propensity of motion is rooted in their emphasis on Shakespeare as a highly mobile cultural signifier which seems confirmed by the monologues' journeys outside the UK. The further adaptational practices triggered by these encounters with foreign audiences are testament to the flexibility of Crouch's dramaturgy of process and its aptitude to accommodate new discursive identities and adjust to each new context of reception.

Análisis estructural a escala regional de la zona de fallas La Trocha

Directory of Open Access Journals (Sweden)

Jesús A. Blanco-Moreno

2007-03-01

Full Text Available Se realiza un análisis estructural a escala regional de la zona de fallas La Trocha, a partir de la interpretación de un gran volumen de información geólogo–geofísica, la cual fue clasificada como: morfométrica, gravimétrica, geológica de superficie y del subsuelo. Se obtuvo el modelo digital del terreno (MDT, a partir de la digitalización de 24 cartas del Mapa Topográfico de la República de Cuba 1:50000, editado por el Instituto Cubano de Geodesia y Cartografía en 1977. El procesamiento del MDT permitió obtener los principales morfoalineamientos de la región. Se procesó la información obtenida del levantamiento gravimétrico de la Cuenca Central a escala 1:100000, elaborándose los mapas de anomalías de Bouguer, continuaciones analíticas ascendentes y de gradientes. La información geológica de superficie se tomó del Mapa Geológico de la República de Cuba 1:100000, editado por el Instituto de Geología y Paleontología en el año 2001; la información geológica del subsuelo proviene de pozos perforados en la Cuenca Central. La información geólogo–geofísica se procesó digitalmente en su totalidad. La interpretación combinada de esta información permitió un acercamiento a las características geométricas de la zona de fallas La Trocha. Se establecieron las direcciones predominantes en la zona de desplazamiento principal y la posible evolución de los esfuerzos tectónicos. Se propone un modelo de evolución para la región, considerando la existencia de una estructura en flor negativa, la cual ajusta las características existentes y explica el desarrollo simultáneo de una cuenca tensional, la Cuenca Central.

Contesting history and identity formation in Paul and in South Africa ...

African Journals Online (AJOL)

This study compares dynamics in the contestation of history and identity between Paul to post-1994 white Afrikaners in South Africa. In reference to Paul, I am interested in how the followers of the nascent Hellenistic Gentile Christian movement claimed legitimacy as the true Jews, usurping the monopoly of the identity 'true ...

On social justice: Comparing Paul with Plato, Aristotle and the Stoics

African Journals Online (AJOL)

p1243322

If Paul tried to establish egalitarian and sharing Christian communities under ... study on Paul for the debate on universal human values – except to suggest ... challenge until, at least for many, Caesar's apotheosis meant not ... just the promise, but the start of the world's salvation, redemption, ..... All will be on a par together.

A DOCUMENT PAUL AUSTER’S NEW YORK TRILOGY

Directory of Open Access Journals (Sweden)

Natalia N. Smirnova

2017-03-01

Full Text Available The article deals with the way a literary work “creates” a document out of itself, on the example of Paul Auster’s novels. A document here is the report of a character, a private detective who is watching another character (a writer but also the book of a fictional writer who is writing a story of the detective who is watching him, and eventually the book about this whole story. In this case, the search for the other, watching him, is inevitably associated with the search for oneself, self-observation. Biography becomes autobiography, e.g. a document rather than a narrative based on a document. This story becomes projected on the story of Don Quixote (of which “some” Paul Auster, a fictional writer, is writing an essay. The Other is a landmark in the vast desert of fictional worlds where Paul Auster’s Don Quixote wanders alongside other characters of the trilogy. The author may not return from his endless journey through imaginary worlds; his life does not belong to either real life or fiction. He gives life to his characters while remaining invisible himself. Paul Auster’s The New York Trilogy explores such existential situation where the only evidence of the author’s life is a document left by his character. The author leaves a documentary record of a kind about his own existence. It this sense, literature is a document of life and of the endless search for a reason to the existence of an individual who, being not equal to him- or herself, is always the other and never a type or a template.

Investigation of T-cell immunoglobulin- and mucin-domain-containing molecule-3 (TIM-3) polymorphisms in essential thrombocythaemia (ET).

Science.gov (United States)

Han, Fuyan; Wang, Guanghai; Li, Yuantang; Tian, Wenjun; Dong, Zhenfang; Cheng, Shiqing; Liu, Yiqing; Qu, Teng; Wang, Xiaoying; Wang, Yong; Zhang, Bingchang; Ju, Ying

2017-07-01

T-cell immunoglobulin- and mucin-domain-containing molecule-3 (TIM-3) is preferentially expressed on terminally differentiated Th1 cells and inhibits their IFN-γ production. It has been reported that chronic inflammation may be an important driving force for myeloproliferative neoplasms (MPNs). Therefore, we hypothesized that as an important inflammation regulator, TIM-3 may be involved in essential thrombocythaemia (ET). The goal of this study was to investigate whether the -1516G > T, -574G > T and +4259T > G single-nucleotide polymorphisms (SNPs) within the TIM-3 gene contribute to the genetic susceptibility of individuals to ET. Genotyping of the TIM-3 -1516G > T, -574G > T and + 4259T > G SNPs was performed in 175 patients with ET and in 151 controls via a polymerase chain reaction-restriction fragment length polymorphism assay. We also investigated the relationships between the genotypes of each SNP and the risk factors of ET such as routine blood indexes, age and JAK2 V617F mutation. The genotype and allele frequencies of the -1516G > T SNP (p = 0.016 and 0.019, respectively), the -574G > T SNP (p = 0.035 and 0.038, respectively) and the +4259T > G SNP (p = 0.036 and 0.038, respectively) of the ET patients and the controls were significantly different. A haplotype analysis found that the GGT and TGT haplotypes had significantly different distributions between ET and controls (p = 0.041 and 0.041, respectively). However, no significant differences were detected between the genotypes of all SNPs and routine blood indexes, age and JAK2V617F mutation. The -1516G > T, -574G > T and +4259T > G SNPs within TIM-3 gene might play an important role as a genetic risk factor in the pathogenesis of ET.

Regulatory effect of gamma-chain cytokines on expression of TIM-3 on CD8+ T cells in patients with chronic hepatitis B

Directory of Open Access Journals (Sweden)

DONG Jie

2015-02-01

Full Text Available ObjectiveTo measure the expression of T-cell immunoglobulin- and mucin domain-3-containing molecule 3 (TIM-3 on CD8+ T cells in peripheral blood mononuclear cells (PBMCs among patients with chronic hepatitis B (CHB and to investigate the effect of common gamma-chain cytokines on the expression of TIM-3 on CD8+ T cells in these patients. MethodsFifteen previously untreated patients with CHB who visited the Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, from January to May, 2014, as well as 8 healthy controls, were included in the study. Blood was collected from these subjects, and PBMCs were isolated from blood by Ficoll density gradient centrifugation. PBMCs were separately stimulated with gamma-chain cytokines, interleukin (IL2, IL-7, IL-15, and IL-21, and anti-CD3/CD28, and the untreated cells were used as a negative control. After four days of culture, PBMCs were stained with monoclonal antibody. Flow cytometry was used to measure the expression of TIM-3 on CD8+ T cells. Comparison of continuous data was made by independent-samples t test. ResultsCompared with the untreated group, the anti-CD3/CD28, IL-2, IL-15, and IL-7 groups had significantly increased expression of TIM-3 on CD8+ T cells (9.629%±9.916%, P=0000 1; 3.817%±2.694%, P = 0.000 6; 5.772%±4.732%, P = 0.005 4; 3.560%±2.045%, P = 0.030 2, while the IL-21 group had nonsignificantly increased expression of TIM-3 on CD8+ T cells (2.503%±2.117%, P = 0.934 1. ConclusionAnti-CD3/CD28 and gamma-chain cytokines IL-2, IL-7, and IL-15 can effectively upregulate the expression of TIM-3 on CD8+ T cells in patients with CHB. It indicates that the inhibition of them can not only reduce the expression of TIM-3, but also may enhance the killing function of CD8+ T cells in patients with CHB.

Tim, Jan Lucas ja Karl Robert - vennad üheks kuuks / Maris Laurits

Index Scriptorium Estoniae

Laurits, Maris

2009-01-01

Rakvere Teatri suvelavastuse "Vennad Lõvisüdamed" kaks Karli osatäitjat Jan Lucas Videvik ja Tim Leesnurm ning Joonatani osatäitja Karl Robert Saaremäe tegid Loksal Kaldmaa talus ratsasõiduproove. Üllar Saaremäe lavastuse "Vennad Lõvisüdamed" (Astrid Lindgreni samanimelise jutustuse järgi) esietendus on 11. juunil Rakvere teatri taga aias

Tim-3-expressing macrophages are functionally suppressed and expanded in oral squamous cell carcinoma due to virus-induced Gal-9 expression.

Science.gov (United States)

Dong, Jianfeng; Cheng, Lijun; Zhao, Minchao; Pan, Xiangfeng; Feng, Zhiqiang; Wang, Dawei

2017-05-01

Oropharyngeal head and neck squamous cell carcinoma is a common malignant tumor in the oral cavity. High-risk human papillomavirus 16 infection is a major cause of oropharyngeal head and neck squamous cell carcinoma development. Strong antitumor immune responses, especially CD8 + T cell responses, are thought to be essential to effective cancer treatment and are associated with better prognosis in oropharyngeal head and neck squamous cell carcinoma. In this study, we examined the role of the Tim-3/Gal-9 pathway in oropharyngeal head and neck squamous cell carcinoma patients. We found that Gal-9 expression by CD4 + T cells was increased in human papillomavirus-positive oropharyngeal head and neck squamous cell carcinoma patients, but not in human papillomavirus-negative oropharyngeal head and neck squamous cell carcinoma patients. Increased Gal-9 secretion by CD4 + T cells presented multiple immunosuppressive effects. Coculturing monocytes with high Gal-9-expressing CD4 + T cells resulted in the expansion of Tim-3 + monocytes, which suppressed interferon gamma production by activated CD8 + T cells. Subsequently, total monocytes incubated with exogenous Gal-9, or high Gal-9-expressing CD4 + T cells, suppressed the expression of interferon gamma by CD8 + T cells. Exogenous Gal-9 and high Gal-9-expressing CD4 + T cells also suppressed the secretion of both interleukin 10 and interleukin 12 by monocytes. These effects are Tim-3/Gal-9-dependent because blocking Tim-3 and/or Gal-9 could enhance the support of CD8 + T cell interferon gamma production and the interleukin 10 and interleukin 12 secretion by monocytes. Together, these data suggest that the high Tim-3 expression in monocytes could be utilized by tumor-promoting Gal-9 expression on CD4 + T cells. Immunotherapy in human papillomavirus-positive oropharyngeal head and neck squamous cell carcinoma patients therefore faces an additional challenge posed by Tim-3 and Gal-9 and likely requires the blockade of these

The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells

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Isabel Gonçalves Silva

2017-08-01

Full Text Available Acute myeloid leukemia (AML is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating cytotoxic lymphoid cells. In this work we discovered a fundamental molecular pathway, which includes ligand-dependent activation of ectopically expressed latrophilin 1 and possibly other G-protein coupled receptors leading to increased translation and exocytosis of the immune receptor Tim-3 and its ligand galectin-9. This occurs in a protein kinase C and mTOR (mammalian target of rapamycin-dependent manner. Tim-3 participates in galectin-9 secretion and is also released in a free soluble form. Galectin-9 impairs the anti-cancer activity of cytotoxic lymphoid cells including natural killer (NK cells. Soluble Tim-3 prevents secretion of interleukin-2 (IL-2 required for the activation of cytotoxic lymphoid cells. These results were validated in ex vivo experiments using primary samples from AML patients. This pathway provides reliable targets for both highly specific diagnosis and immune therapy of AML.

Location - Managed Facility - St. Paul District (MVP)

Data.gov (United States)

Army Corps of Engineers, Department of the Army, Department of Defense — St. Paul District - US Army Corps of Engineers Managed Facility locations. District headquarters, Natural Resource, Recreation, Lock and Dam, and Regulatory offices...

Structural analysis on mutation residues and interfacial water molecules for human TIM disease understanding

Science.gov (United States)

2013-01-01

Background Human triosephosphate isomerase (HsTIM) deficiency is a genetic disease caused often by the pathogenic mutation E104D. This mutation, located at the side of an abnormally large cluster of water in the inter-subunit interface, reduces the thermostability of the enzyme. Why and how these water molecules are directly related to the excessive thermolability of the mutant have not been investigated in structural biology. Results This work compares the structure of the E104D mutant with its wild type counterparts. It is found that the water topology in the dimer interface of HsTIM is atypical, having a "wet-core-dry-rim" distribution with 16 water molecules tightly packed in a small deep region surrounded by 22 residues including GLU104. These water molecules are co-conserved with their surrounding residues in non-archaeal TIMs (dimers) but not conserved across archaeal TIMs (tetramers), indicating their importance in preserving the overall quaternary structure. As the structural permutation induced by the mutation is not significant, we hypothesize that the excessive thermolability of the E104D mutant is attributed to the easy propagation of atoms' flexibility from the surface into the core via the large cluster of water. It is indeed found that the B factor increment in the wet region is higher than other regions, and, more importantly, the B factor increment in the wet region is maintained in the deeply buried core. Molecular dynamics simulations revealed that for the mutant structure at normal temperature, a clear increase of the root-mean-square deviation is observed for the wet region contacting with the large cluster of interfacial water. Such increase is not observed for other interfacial regions or the whole protein. This clearly suggests that, in the E104D mutant, the large water cluster is responsible for the subunit interface flexibility and overall thermolability, and it ultimately leads to the deficiency of this enzyme. Conclusions Our study

High-precision isotopic characterization of USGS reference materials by TIMS and MC-ICP-MS

Science.gov (United States)

Weis, Dominique; Kieffer, Bruno; Maerschalk, Claude; Barling, Jane; de Jong, Jeroen; Williams, Gwen A.; Hanano, Diane; Pretorius, Wilma; Mattielli, Nadine; Scoates, James S.; Goolaerts, Arnaud; Friedman, Richard M.; Mahoney, J. Brian

2006-08-01

The Pacific Centre for Isotopic and Geochemical Research (PCIGR) at the University of British Columbia has undertaken a systematic analysis of the isotopic (Sr, Nd, and Pb) compositions and concentrations of a broad compositional range of U.S. Geological Survey (USGS) reference materials, including basalt (BCR-1, 2; BHVO-1, 2), andesite (AGV-1, 2), rhyolite (RGM-1, 2), syenite (STM-1, 2), granodiorite (GSP-2), and granite (G-2, 3). USGS rock reference materials are geochemically well characterized, but there is neither a systematic methodology nor a database for radiogenic isotopic compositions, even for the widely used BCR-1. This investigation represents the first comprehensive, systematic analysis of the isotopic composition and concentration of USGS reference materials and provides an important database for the isotopic community. In addition, the range of equipment at the PCIGR, including a Nu Instruments Plasma MC-ICP-MS, a Thermo Finnigan Triton TIMS, and a Thermo Finnigan Element2 HR-ICP-MS, permits an assessment and comparison of the precision and accuracy of isotopic analyses determined by both the TIMS and MC-ICP-MS methods (e.g., Nd isotopic compositions). For each of the reference materials, 5 to 10 complete replicate analyses provide coherent isotopic results, all with external precision below 30 ppm (2 SD) for Sr and Nd isotopic compositions (27 and 24 ppm for TIMS and MC-ICP-MS, respectively). Our results also show that the first- and second-generation USGS reference materials have homogeneous Sr and Nd isotopic compositions. Nd isotopic compositions by MC-ICP-MS and TIMS agree to within 15 ppm for all reference materials. Interlaboratory MC-ICP-MS comparisons show excellent agreement for Pb isotopic compositions; however, the reproducibility is not as good as for Sr and Nd. A careful, sequential leaching experiment of three first- and second-generation reference materials (BCR, BHVO, AGV) indicates that the heterogeneity in Pb isotopic compositions

Evaluación de la resistencia al cizallamiento por compresión y falla en madera de uniones encoladas en maderas nacionales e importadas

Directory of Open Access Journals (Sweden)

Sebastián Quagliotti

2011-05-01

Full Text Available En el presente trabajo se muestran los resultados de la evaluación de la resistencia al cizallamiento por compresión y falla en madera de uniones encoladas en Eucalyptus grandis, Pinus taeda, Pinus eliottii, lapacho y cedro. El procedimiento se basó en las siguientes normas: ASTM D 5751-99, JIS K 6852-1994 y EN 205:1991. Las etapas más relevantes fueron las siguientes: encolado y corte de probetas, tratamientos de inmersión en agua a 30 ºC, 60 ºC, 100 ºC y ensayo en máquina universal. Se determinó la resistencia al cizallamiento por compresión, retención del poder adhesivo y porcentaje de falla en madera. Es posible concluir que el PVA no es un adhesivo para ser utilizado en ambientes de alta humedad, debido a los bajos valores de resistencia y porcentaje de falla comparados con los valores en seco, como se muestra en las especies  estudiadas luego de ser sometidas a los diferentes tratamientos. Cabe resaltar que, una vez realizados los tratamientos de inmersión, las probetas encoladas con isocianato de E. grandis tienen los valores de retención del poder adhesivo más altos, como también menor disminución del porcentaje de falla en madera en comparación con las otras especies estudiadas.AbstractThe results of the shear strength (by compression and wood failure of bond unions in Eucalyptus grandis, Pinus taeda, Pinus eliottii, Tabebuia ipe y Cedrela spp are shown in the present work. The process was based on the following standards: ASTM D 5751-99, JIS K 6852-1994 y EN 205:1991. The most relevant stageswere bonding and the cutting of samples, water immersion treatment (30, 60, 100 ºC and universal machine test. Shear strength, Ratio wet/dry shear and Wood Failure percentage were determined. As a conclusion, the PVA is not an adhesive to be used under high humidity conditions, due to the low values of shear strength and percentage of wood failure that the study species shown after water immersion treatment compared with the

Paul van Ostaijen en het primitivisme

NARCIS (Netherlands)

Laan, N.

2010-01-01

Though Paul van Ostaijen has always been put within the context of the historical avant-garde, his relationship to primitivism has never been the subject of study. That is strange, for primitivism is commonly seen as one of the defining characteristics of the avant-garde. Even stranger is that

Classical Sax: Conversation with Paul Brodie.

Science.gov (United States)

Row, David W.

1984-01-01

Paul Brodie, the most recorded concert saxophonist in the history of the instrument, talks about a number of topics, including his career, differences among saxophonists, mixing styles of playing, the effectiveness of music schools, and whether it is necessary to understand the structure of the piece being played. (RM)

Paul-Eerik Rummo : mind käimashoidev vedru on presidendiprotsess ise / Paul-Eerik Rummo ; interv. Märt Kivine

Index Scriptorium Estoniae

Rummo, Paul-Eerik, 1942-

2006-01-01

Intervjuus Reformierakonna ühe presidendikandidaadi, rahvastikuminister Paul-Eerik Rummoga käsitletakse presidendi rolli, ülesandeid, rahva ootusi, Eesti ideed Euroopas, EL-i laienemist. Tema hinnangul on võtmeteema haridus, sellest oleneb ka kõige muu õnnestumine, ka rahvuse edasikestmine

Cold highly charged ions in a cryogenic Paul trap

Energy Technology Data Exchange (ETDEWEB)

Versolato, O. O., E-mail: oscar.versolato@mpi-hd.mpg.de; Schwarz, M.; Windberger, A.; Ullrich, J. [Max-Planck-Institut fuer Kernphysik (Germany); Schmidt, P. O. [Physikalisch-Technische Bundesanstalt (Germany); Drewsen, M. [University of Aarhus, Department of Physics and Astronomy (Denmark); Crespo Lopez-Urrutia, J. R. [Max-Planck-Institut fuer Kernphysik (Germany)

2013-03-15

Narrow optical transitions in highly charged ions (HCIs) are of particular interest for metrology and fundamental physics, exploiting the high sensitivity of HCIs to new physics. The highest sensitivity for a changing fine structure constant ever predicted for a stable atomic system is found in Ir{sup 17 + }. However, laser spectroscopy of HCIs is hindered by the large ({approx} 10{sup 6} K) temperatures at which they are produced and trapped. An unprecedented improvement in such laser spectroscopy can be obtained when HCIs are cooled down to the mK range in a linear Paul trap. We have developed a cryogenic linear Paul trap in which HCIs will be sympathetically cooled by {sup 9}Be{sup + } ions. Optimized optical access for laser light is provided while maintaining excellent UHV conditions. The Paul trap will be connected to an electron beam ion trap (EBIT) which is able to produce a wide range of HCIs. This EBIT will also provide the first experimental input needed for the determination of the transition energies in Ir{sup 17 + }, enabling further laser-spectroscopic investigations of this promising HCI.

Tim Peake and Britain's road to space

CERN Document Server

Seedhouse, Erik

2017-01-01

This book puts the reader in the flight suit of Britain’s first male astronaut, Tim Peake. It chronicles his life, along with the Principia mission and the down-to-the-last-bolt descriptions of life aboard the ISS, by way of the hurdles placed by the British government and the rigors of training at Russia’s Star City military base. In addition, this book discusses the learning curves required in astronaut and mission training and the complexity of the technologies required to launch an astronaut and keep them alive for months on end. This book underscores the fact that technology and training, unlike space, do not exist in a vacuum; complex technical systems, like the ISS, interact with the variables of human personality, and the cultural background of the astronauts. .

Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9.

Science.gov (United States)

Schwartz, Jordan Ari; Clayton, Kiera L; Mujib, Shariq; Zhang, Hongliang; Rahman, A K M Nur-Ur; Liu, Jun; Yue, Feng Yun; Benko, Erika; Kovacs, Colin; Ostrowski, Mario A

2017-04-15

In chronic diseases, such as HIV infection, plasmacytoid dendritic cells (pDCs) are rendered dysfunctional, as measured by their decreased capacity to produce IFN-α. In this study, we identified elevated levels of T cell Ig and mucin-domain containing molecule-3 (Tim-3)-expressing pDCs in the blood of HIV-infected donors. The frequency of Tim-3-expressing pDCs correlated inversely with CD4 T cell counts and positively with HIV viral loads. A lower frequency of pDCs expressing Tim-3 produced IFN-α or TNF-α in response to the TLR7 agonists imiquimod and Sendai virus and to the TLR9 agonist CpG. Thus, Tim-3 may serve as a biomarker of pDC dysfunction in HIV infection. The source and function of Tim-3 was investigated on enriched pDC populations from donors not infected with HIV. Tim-3 induction was achieved in response to viral and artificial stimuli, as well as exogenous IFN-α, and was PI3K dependent. Potent pDC-activating stimuli, such as CpG, imiquimod, and Sendai virus, induced the most Tim-3 expression and subsequent dysfunction. Small interfering RNA knockdown of Tim-3 increased IFN-α secretion in response to activation. Intracellular Tim-3, as measured by confocal microscopy, was dispersed throughout the cytoplasm prior to activation. Postactivation, Tim-3 accumulated at the plasma membrane and associated with disrupted TLR9 at the submembrane. Tim-3-expressing pDCs had reduced IRF7 levels. Furthermore, intracellular Tim-3 colocalized with p85 and IRF7 within LAMP1 + lysosomes, suggestive of a role in degradation. We conclude that Tim-3 is a biomarker of dysfunctional pDCs and may negatively regulate IFN-α, possibly through interference with TLR signaling and recruitment of IRF7 and p85 into lysosomes, enhancing their degradation. Copyright © 2017 by The American Association of Immunologists, Inc.

Análisis estocástico de señales vibratorias de motores de inducción para la detección de fallas usando descomposición de modo empírico

Directory of Open Access Journals (Sweden)

Alejandro Rivera Roldán

2015-04-01

Full Text Available En este artículo se presenta un análisis de vibraciones en motores de inducción por medio de Modelos Ocultos de Markov (Hidden Markov Model - HMM aplicado a características obtenidas de la Descomposición de Modo Empírico (Empirical Mode Decomposition - EMD y transformada de Hilbert-Huang de señales de vibración obtenidas en las coordenadas x y y, con el fin de detectar fallas de funcionamiento en rodamientos y barras.  Además se presenta un análisis comparativo de la capacidad de las señales de vibración en dirección x y en dirección y, para aportar información en la detección de fallas. Así, un HMM ergódico inicializado y entrenado por medio del algoritmo de máxima esperanza, con convergencia en 10e-7 y un máximo de iteraciones de 100, se aplicó sobre el espacio de características y su desempeño fue determinado mediante validación cruzada 80-20 con 30 fold, obteniendo un alto desempeño para la detección de fallas en términos de exactitud.

A novel method for sampling the suspended sediment load in the tidal environment using bi-directional time-integrated mass-flux sediment (TIMS) samplers

Science.gov (United States)

Elliott, Emily A.; Monbureau, Elaine; Walters, Glenn W.; Elliott, Mark A.; McKee, Brent A.; Rodriguez, Antonio B.

2017-12-01

Identifying the source and abundance of sediment transported within tidal creeks is essential for studying the connectivity between coastal watersheds and estuaries. The fine-grained suspended sediment load (SSL) makes up a substantial portion of the total sediment load carried within an estuarine system and efficient sampling of the SSL is critical to our understanding of nutrient and contaminant transport, anthropogenic influence, and the effects of climate. Unfortunately, traditional methods of sampling the SSL, including instantaneous measurements and automatic samplers, can be labor intensive, expensive and often yield insufficient mass for comprehensive geochemical analysis. In estuaries this issue is even more pronounced due to bi-directional tidal flow. This study tests the efficacy of a time-integrated mass sediment sampler (TIMS) design, originally developed for uni-directional flow within the fluvial environment, modified in this work for implementation the tidal environment under bi-directional flow conditions. Our new TIMS design utilizes an 'L' shaped outflow tube to prevent backflow, and when deployed in mirrored pairs, each sampler collects sediment uniquely in one direction of tidal flow. Laboratory flume experiments using dye and particle image velocimetry (PIV) were used to characterize the flow within the sampler, specifically, to quantify the settling velocities and identify stagnation points. Further laboratory tests of sediment indicate that bidirectional TIMS capture up to 96% of incoming SSL across a range of flow velocities (0.3-0.6 m s-1). The modified TIMS design was tested in the field at two distinct sampling locations within the tidal zone. Single-time point suspended sediment samples were collected at high and low tide and compared to time-integrated suspended sediment samples collected by the bi-directional TIMS over the same four-day period. Particle-size composition from the bi-directional TIMS were representative of the array of

John Paul College: The Professional Renewal Journey

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Pauline Mundie

2014-09-01

Full Text Available John Paul College, a K-12 School in Queensland, Australia, recognises the centrality of classroom teachers to the ongoing improvement of student outcomes. The college has implemented a multi-tiered professional renewal and assessment process. These changes of emphasis are the result of significant research and subsequent/associated professional discussion and were supported during the EBA decision-making in 2012. The professional renewal process at John Paul College guides teachers through a cycle of goal setting (related to any aspect of teacher practice which aims to improve student learning and achievement; ongoing discussion between the teacher and a mentor which determines actions; directed classroom observations (3 per term and associated pre and post reflection/discussion; leading to application of changed practice toward achieving the criteria of the goals. The principles of the professional renewal program are to:  enhance development along accepted school-wide, team and department goals;  encourage professional pedagogical reflections and conversations with a colleague/mentor;  motivate improved performance and highlight the next steps in a teacher’s development. Through the introduction of professional renewal, attestation and exemplary teacher processes, the leadership and teachers of John Paul College have achieved an appropriate and innovative balance between self-directed, peer supported/directed and college-wide, strategic initiatives. Each member of the teaching team, from graduate to senior leaders are actively engaged in personalised programs of professional growth which is specifically aimed at improved learning and outcomes of the college’s students.

The Jesus of Paul: A contribution from the social sciences

Directory of Open Access Journals (Sweden)

Santiago Guijarro

2011-04-01

Determining the relationship between Jesus and Paul is one of the fundamental tasks of those who, like Prof. Andries van Aarde, study the origins of Christianity and the beginnings of Christian theology. The basic question in this regard, at least as it has been formulated recently by David Wenham (1995, is whether Paul was a follower of Jesus or the founder of Christianity (see also Wedderburn [1989] and Barbaglio [2006]. In this brief article, I would like to consider one aspect of this general topic and to offer a few suggestions that might contribute to a better understanding of the peculiar vision of Jesus that we find in the letters of Paul. In them, in fact, the apostle moves from the incarnation to the death and resurrection, leaving in the shadows the activity and teaching of Jesus to which the gospels subsequently give so much importance. This contrast raises some questions concerning the knowledge which Paul had of the Jesus tradition and the value he accorded to it: What did he know about Jesus? Did he know the traditions which the evangelists later collected? Why does he not refer to them in his letters more frequently? By contrast, why does he give so much importance to the death and resurrection of Jesus and to Jesus’ divine condition?

Integrated Modeling System for Analysis of Watershed Water Balance: A Case Study in the Tims Branch Watershed, South Carolina

Science.gov (United States)

Setegn, S. G.; Mahmoudi, M.; Lawrence, A.; Duque, N.

2015-12-01

The Applied Research Center at Florida International University (ARC-FIU) is supporting the soil and groundwater remediation efforts of the U.S. Department of Energy (DOE) Savannah River Site (SRS) by developing a surface water model to simulate the hydrology and the fate and transport of contaminants and sediment in the Tims Branch watershed. Hydrological models are useful tool in water and land resource development and decision-making for watershed management. Moreover, simulation of hydrological processes improves understanding of the environmental dynamics and helps to manage and protect water resources and the environment. MIKE SHE, an advanced integrated modeling system is used to simulate the hydrological processes of the Tim Branch watershed with the objective of developing an integrated modeling system to improve understanding of the physical, chemical and biological processes within the Tims Branch watershed. MIKE SHE simulates water flow in the entire land based phase of the hydrological cycle from rainfall to river flow, via various flow processes such as, overland flow, infiltration, evapotranspiration, and groundwater flow. In this study a MIKE SHE model is developed and applied to the Tim branch watershed to study the watershed response to storm events and understand the water balance of the watershed under different climatic and catchment characteristics. The preliminary result of the integrated model indicated that variation in the depth of overland flow highly depend on the amount and distribution of rainfall in the watershed. The ultimate goal of this project is to couple the MIKE SHE and MIKE 11 models to integrate the hydrological component in the land phase of hydrological cycle and stream flow process. The coupled MIKE SHE/MIKE 11 model will further be integrated with an Ecolab module to represent a range of water quality, contaminant transport, and ecological processes with respect to the stream, surface water and groundwater in the Tims

Investigation of two-frequency Paul traps for antihydrogen production

Energy Technology Data Exchange (ETDEWEB)

Leefer, Nathan; Krimmel, Kai, E-mail: kkrimmel@students.uni-mainz.de [Helmholtz-Institut Mainz (Germany); Bertsche, William [University of Manchester (United Kingdom); Budker, Dmitry [Helmholtz-Institut Mainz (Germany); Fajans, Joel [University of California at Berkeley, Department of Physics (United States); Folman, Ron [Ben-Gurion University of the Negev, Department of Physics (Israel); Häffner, Hartmut [University of California at Berkeley, Department of Physics (United States); Schmidt-Kaler, Ferdinand [Helmholtz-Institut Mainz (Germany)

2017-11-15

Radio-frequency (rf) Paul traps operated with multifrequency rf trapping potentials provide the ability to independently confine charged particle species with widely different charge-to-mass ratios. In particular, these traps may find use in the field of antihydrogen recombination, allowing antiproton and positron clouds to be trapped and confined in the same volume without the use of large superconducting magnets. We explore the stability regions of two-frequency Paul traps and perform numerical simulations of small samples of multispecies charged-particle mixtures of up to twelve particles that indicate the promise of these traps for antihydrogen recombination.

Meet EPA Ecologist Paul Mayer, Ph.D.

Science.gov (United States)

EPA ecologist Paul Mayer, Ph.D. works in EPA's Groundwater and Ecosystem Restoration division where he studies riparian zones (the area along rivers and streams where the habitats are influenced by both the land and water) and stream restoration

Competencia de los cuidadores familiares para cuidar a los pacientes con falla cardíaca

Directory of Open Access Journals (Sweden)

Diana Marcela Achury Saldaña

2017-09-01

Full Text Available Introducción: El cuidador familiar es la fuente más importante de apoyo social y requiere desarrollar habilidades para reforzar las conductas de autocuidado en su familiar. El objetivo de este estudio fue determinar la competencia de cuidado de los cuidadores familiares de los pacientes con falla cardiaca (FC en una institución de cuarto nivel de complejidad. Materiales y Métodos: Estudio descriptivo de corte transversal. Con un tamaño de muestra de 41 cuidadores familiares de personas con FC que asisten al programa de FC en una institución de salud de cuarto nivel, durante el segundo semestre del 2016. Para la recolección de la información se utilizó el instrumento “CUIDAR” que cuenta con pruebas de validez de constructo y consistencia interna con un alfa de Cronbach de 0.93. Se realizó un análisis descriptivo con distribución de frecuencias absolutas y relativas. Resultados: El nivel de competencia global para el cuidado en el hogar de los cuidadores familiares de los pacientes con FC fue medio y alto. Las dimensiones que alcanzaron un nivel más alto de competencia fueron Disfrutar e Instrumental y Procedimental. Discusión: Una adecuada competencia para el cuidado en los cuidadores se convierte en un factor que puede influir de manera positiva en el manejo de la persona. Conclusiones: Una adecuada competencia del cuidador familiar va a permitir una mejor adaptación a los nuevos requerimientos de la vida del paciente con su enfermedad y pueden ayudar a prevenir las descompensaciones. Cómo citar este artículo: Achury DM, Restrepo A, Torres NM, Buitrago AL, Neira NX, Devia P. Competencia de los cuidadores familiares para cuidar a los pacientes con falla cardíaca. Rev Cuid. 2017; 8(3: 1721-32. http://dx.doi.org/10.15649/cuidarte.v8i3.407

WHAT HAPPENED TO THE GALATIAN CHRISTIANS? PAUL'S ...

African Journals Online (AJOL)

Paul's Letter to the Galatians points to the influence of his missionary ... of the apostle's name in the first four centuries. .... Acta Theologica Supplementum 19. 2014 .... The author states that they spoke the word in Perge, not implying that they.

XXI sajandi kontuurid / Paul Johnson ; refereerinud Mihkel Mutt

Index Scriptorium Estoniae

Johnson, Paul

1997-01-01

Washingtonis 14.-16. juunini peetud 'Lääne kirjanduse konverentsil' pidas põhiettekande ameerika ajaloolane ja publitsist Paul Johnson. Refereering tema 'XXI sajandi geopoliitiliste ja kultuuriliste väljavaadete' seisukohtadest

Obscurity of poetry in Paul Celan

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Mauricio Mendonça Cardozo

2012-07-01

Full Text Available Tensioned between variations of the said and the unsaid, and between figures of light and shadow, Paul Celan's work performs a certain confrontation with the condition of silence and obscurity, breaking all at once with a certain way of making poetry and of relating to reality. In this sense, Celan's work can hardly be reduced to a kind of hermeticism, a category too vague to account for its singularity. In his work saying and silencing together articulate the tension that creates the poetic space in which the poem is inscribed. The poet himself tried to refuse the insistence of some critics on labeling his work as obscure. Despite of its fragmentary nature, the recently published manuscripts of his speech project Von der Dunkelheit des Dichterischen constitutes one of Celan’s most extensive discussions of the matter of obscurity in poetry. This paper aims at presenting the fragments of his speech project and pointing out its importance to the discussion of the notion of obscurity in Paul Celan's work.

Tim Allen, one of Hollywood's top comedy actors with Rolf Landua from CERN

CERN Multimedia

Laurent Guiraud

2000-01-01

Tim Allen ('Galaxy Quest', 'For Richer and Poorer', 'The Santa Clause', Voice of 'Buzz Lightyear', in Toy Story 1 and 2), visited CERN in July 2000. He has a keen interest in modern physics. In his last book "I'm not really here" he contemplates the funny and the intriguing aspects of quantum physics in his daily life.

Elevación diafragmática con colapso de la aurícula derecha y síntomas de falla cardíaca: Reporte de un caso

Directory of Open Access Journals (Sweden)

Juan C. Díaz, MD

2013-01-01

Se reporta el caso de una paciente que presentó signos y síntomas compatibles con falla cardíaca derecha y en quien los diferentes estudios demostraron una elevación diafragmática con colapso de la aurícula derecha como causa de su sintomatología.

The present day relevance of Paul's advice to the family in the ...

African Journals Online (AJOL)

Many people and organizations have made several efforts to improve and enhance the survival of the family. An example is the advice of Saint Paul, the Apostle to the Christian family in Ephesians 5:22-25 and 6:1-9. This paper examines this advice and its relevance to the society today. Key Words: Paul, Apostle; Advice; ...

Paul Kard and Lorentz-free special relativity

International Nuclear Information System (INIS)

Karlov, L.

1989-01-01

The late Professor Paul Kard of Tartu, Estonia, worked on some interesting derivations of formulae from relativistic kinematics and the dependence of mass on speed. These may prove useful to physics educators as they break the mould of traditional textbook presentations. (UK)

La banda sonora del programa «Rá-Tim-Bum»

OpenAIRE

Almeida Duarte, Mônica de

2005-01-01

Esta comunicación trata de los resultados parciales de la investigación vuelta para el análisis de la banda sonora del programa televisivo Rá-Tim-Bum, de TV Educativa, empresa gubernamental. Se utiliza un cuadro teórico-metodológico de análisis de los discursos aplicado a la música propuesto por Amparo Porta por medio de tres niveles de aproximación: verosimilitud referencial (las calidades sonoras), poética (tratamiento de frases y de finalización) y tópica (ideologia difundida). El...

PD-1hiTIM-3+ T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation

International Nuclear Information System (INIS)

Kong, Y; Zhang, J; Claxton, D F; Ehmann, W C; Rybka, W B; Zhu, L; Zeng, H; Schell, T D; Zheng, H

2015-01-01

Prognosis of leukemia relapse post allogeneic stem cell transplantation (alloSCT) is poor and effective new treatments are urgently needed. T cells are pivotal in eradicating leukemia through a graft versus leukemia (GVL) effect and leukemia relapse is considered a failure of GVL. T-cell exhaustion is a state of T-cell dysfunction mediated by inhibitory molecules including programmed cell death protein 1 (PD-1) and T-cell immunoglobulin domain and mucin domain 3 (TIM-3). To evaluate whether T-cell exhaustion and inhibitory pathways are involved in leukemia relapse post alloSCT, we performed phenotypic and functional studies on T cells from peripheral blood of acute myeloid leukemia patients receiving alloSCT. Here we report that PD-1 hi TIM-3 + cells are strongly associated with leukemia relapse post transplantation. Consistent with exhaustion, PD-1 hi TIM-3 + T cells are functionally deficient manifested by reduced production of interleukin 2 (IL-2), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). In addition, these cells demonstrate a phenotype consistent with exhausted antigen-experienced T cells by losing T N and T EMRA subsets. Importantly, increase of PD-1 hi TIM-3 + cells occurs before clinical diagnosis of leukemia relapse, suggesting their predictive value. Results of our study provide an early diagnostic approach and a therapeutic target for leukemia relapse post transplantation

Parallel Narrative Structure in Paul Harding's "Tinkers"

Science.gov (United States)

Çirakli, Mustafa Zeki

2014-01-01

The present paper explores the implications of parallel narrative structure in Paul Harding's "Tinkers" (2009). Besides primarily recounting the two sets of parallel narratives, "Tinkers" also comprises of seemingly unrelated fragments such as excerpts from clock repair manuals and diaries. The main stories, however, told…

R-ES-ONANCE--INo-ve-mber

Indian Academy of Sciences (India)

Physiology or Medicine: has been jointly awarded to. Leland H Hartwell, Fred Hutchinson Cancer Research Center, University of Seattle, USA. R Timothy (Tim) Hunt, Clare Hall Laboratories, Cell Cycle Control Laboratory, UK. Paul M Nurse, Lincoln's Inn Fields Laboratories, Cell Cycle Laboratory, UK for their discoveries of ...

Leben mit Estland : Paul-Gerhard von Hoerschelmann zum 80. Geburtstag / Heinrich Wittram

Index Scriptorium Estoniae

Wittram, Heinrich

2012-01-01

Olles Põhja-Elbe Jutlustajate Seminari direktor alustas Paul-Gerhard von Hoerschelmann koostööd Eesti Evangeelse Luterliku Kirikuga 1988. aastal. Nõmmel sündinud pastori pojana olid tal selle koostöö arendamiseks igati head eeldused. 1997. aastal sai Paul-Gerhard Hoerschelmannist EELK Usuteaduse Instituudi rektor. Aastatel 1996-1998 teenis ta väikesearvulist saksakeelset kogudust Tallinnas. Aastast 2006 EELK' aupraost

Vahur-Paul Põldma - tõlkis raamatu, lavastas etenduse, ise mängib ja üksi / Vahur-Paul Põldma ; interv. Triin Tael

Index Scriptorium Estoniae

Põldma, Vahur-Paul

2008-01-01

Alessandro Baricco teos "Novecento", mida Vahur-Paul Põldma mängib Uue Vana Teatri nime all ühemeheetendusena. Lisaks tutvustus "Kes on Alessandro Baricco?" ja "Vahur-Pauli salaminevik : töö lasteaiakasvatajana"

High affinity anti-TIM-3 and anti-KIR monoclonal antibodies cloned from healthy human individuals.

Directory of Open Access Journals (Sweden)

Stefan Ryser

Full Text Available We report here the cloning of native high affinity anti-TIM-3 and anti-KIR IgG monoclonal antibodies (mAbs from peripheral blood mononuclear cells (PBMC of healthy human donors. The cells that express these mAbs are rare, present at a frequency of less than one per 105 memory B-cells. Using our proprietary multiplexed screening and cloning technology CellSpot™ we assessed the presence of memory B-cells reactive to foreign and endogenous disease-associated antigens within the same individual. When comparing the frequencies of antigen-specific memory B-cells analyzed in over 20 screening campaigns, we found a strong correlation of the presence of anti-TIM-3 memory B-cells with memory B-cells expressing mAbs against three disease-associated antigens: (i bacterial DNABII proteins that are a marker for Gram negative and Gram positive bacterial infections, (ii hemagglutinin (HA of influenza virus and (iii the extracellular domain of anaplastic lymphoma kinase (ALK. One of the native anti-KIR mAbs has similar characteristics as lirilumab, an anti-KIR mAb derived from immunization of humanized transgenic mice that is in ongoing clinical trials. It is interesting to speculate that these native anti-TIM-3 and anti-KIR antibodies may function as natural regulatory antibodies, analogous to the pharmacological use in cancer treatment of engineered antibodies against the same targets. Further characterization studies are needed to define the mechanisms through which these native antibodies may function in healthy and disease conditions.

LITERASI MEDIA SEBAGAI STRATEGI KOMUNIKASI TIM SUKSES RELAWAN PEMENANGAN PEMILIHAN PRESIDEN JOKOWI JK DI BANDUNG

Directory of Open Access Journals (Sweden)

Annisa Senova

2016-12-01

Full Text Available Memahami kegiatan literasi media yang terjadi dalam kehidupan berorganisasi akan memberikan gambaran yang jelas tentang kemampuan mengidentifikasi, menentukan, mengorganisir, dan menggunakan media, serta menjadikan informasi sebagai bahan pertimbangan pembuatan keputusan tim sukses relawan pemenangan Presiden Joko Widodo dan Jusuf Kalla di Bandung. Oleh karena itu, penelitian ini dilakukan untuk menemukan kegiatan literasi media sebagai strategi komunikasi tim sukses relawan pemenangan pemilihan presiden Joko Widodo dan Jusuf Kalla. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan pendekatan studi kasus. Penelitian ini menggunakan teknik pengumpulan data berupa wawancara mendalam, observasi, dan studi dokumentasi. Teknik pemeriksaan keabsahan data yang digunakan dalam penelitian ini adalah dengan triangulasi data sumber. Media sosial menjadi media utama dalam proses penyampaian pesan kepada khalayak di kota Bandung. Terdapat beberapa jenis media sosial yang akan digunakan secara rutin dalam proses tersebut, yaitu Twitter, Facebook, Instagram, dan Youtube. Namun, timses relawan media sosial hanya fokus kepada dua jenis media sosial yang dianggap dapat mempengaruhi pandangan publik. Twiter dan Instagram dianggap mampu menjadi jejaring sosial yang efektif dalam proses penyampaian pesan politik pemilu 2014. Penyampaian informasi oleh timses relawan media sosial kepada masyarakat melalui Twitter dan Instagram dianggap sangat efektif dan tepat. Konten-konten yang disediakan oleh akun Twitter sangat mudah untuk diakses oleh semua kalangan. Penelitian tantang proses literasi media tim sukses relawan pemenangan presiden Jokowi-Jk ini dapat menambah masukan bagi ilmu komunikasi, terutama dalam bidang literasi media, bahwa saat ini keberadaan media dapat menjadi sebuah strategi komunikasi yang cukup efektif.   DOI: 10.24198/jkk.vol4n2.3

75 FR 67303 - Determinations of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur...

Science.gov (United States)

2010-11-02

... of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur/Douglas PM 10... proposes to determine that the Hayden, Nogales, and Paul Spur/Douglas nonattainment areas in Arizona... Hayden, Nogales and Paul Spur/Douglas nonattainment areas are not currently attaining the PM 10 standard...

[From Paul Flechsig to the Paul Flechsig Institute for Brain Research. Development of brain research at the Karl Marx University].

Science.gov (United States)

Leibnitz, L; Werner, L; Schober, W; Brauer, K

1977-04-01

A review is given on the development of the brain research institute of the Karl-Marx-University of Leipzig during the directorates of Paul Flechsig (1883-1920), Richard Arwed Pfeifer (1925-1957), and Wolfgang Wünscher (1957-1971).

Paul Lacoste, Portraits sensibles

OpenAIRE

Laplace-Treyture, Danièle

2013-01-01

Des vignerons indépendants et non pas coopérateurs ; des parcelles accrochées à des versants au lieu d’une vaste plaine viticole ; des vins certifiés bio et un vignoble en biodynamie... C’est autour de Jonquières et d’Aniane (communes situées entre Lodève et Montpellier), que Paul Lacoste a choisi de filmer un nouveau « tournant qualitatif » pris par la viticulture en Languedoc. Le documentaire (un feuilleton en six épisodes) bouscule quelque peu nos représentations collectives de ce Midi vit...

Paul Langerhans: a prilgrim "traveling" from functional histology to marine biology.

Science.gov (United States)

Raica, Marius; Cimpean, Anca Maria

2017-06-01

The nineteenth century was the time of a real revolution in science and medicine. A lot of seminal discoveries in medicine and biology were done in this time, and many of them were coincident with the introduction of the compound microscope by Hermann van Deijl and the standard histological technique by Paul Ehrlich. The main tissue types and individual cells were characterized and originally classified more than hundred years ago, although less attention was paid to their basic functions. This was mainly due to the modality of tissue specimen processing that allowed particularly detailed descriptive studies. Even so, we can notice some attempts to correlate the structure with the function. The German scientist Paul Langerhans, well-known for the discovery of Langerhans islets of the pancreas and Langerhans cells from the epidermis, tried to change the conventional fate of morphological studies introducing in his works functional hypothesis based on traditional microscopic observations even from the beginning of his scientific career. Paul Langerhans was a complex personality of the second half of the nineteenth century, not only in medicine, but also in other fields of biology. In the present review, presented is the life and research activity of Paul Langerhans, not only because of the importance of his discoveries, but also for perspectives that were opened by these findings in unexpected fields of medicine and biology.

Walking Between Houses, Paul Julien in Sudan

NARCIS (Netherlands)

Elsadig Mohamed; Andrea Stultiens

2015-01-01

April 2015 Sudanese photographer Elsadig Mohamed and I tried to relate the photographs that Paul Julien made when traveling through the country in 1933 and 1948 to stories and realities alive in present day Sudan. This initial research was pretty successful and we thought a first presentation of the

Walking between houses, Paul Julien in Sudan

NARCIS (Netherlands)

Stultiens, Andrea; Mohamed, Elsadig

2015-01-01

April 2015 Sudanese photographer Elsadig Mohamed and I tried to relate the photographs that Paul Julien made when traveling through the country in 1933 and 1948 to stories and realities alive in present day Sudan. This initial research was pretty successful and we thought a first presentation of the

Statins reduce the expressions of Tim-3 on NK cells and NKT cells in atherosclerosis.

Science.gov (United States)

Zhang, Na; Zhang, Min; Liu, Ru-Tao; Zhang, Peng; Yang, Chun-Lin; Yue, Long-Tao; Li, Heng; Li, Yong-Kang; Duan, Rui-Sheng

2018-02-15

3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have an immuno-regulatory effect in addition to lowing-lipids. Accumulated evidence showed that the expressions of T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) on natural killer (NK) cells increased in atherosclerotic patients and animal models. In this study, 14 patients treated with rosuvastatin and 12 patients with atorvastatin for more than 3 months were included and 20 patients without statins treatment as control. Both statins treatment reduced the expressions of Tim-3 on NK cells and their subtypes, natural killer T (NKT) cells and CD3 + T cells, and increased the proportions of NKT cells among peripheral blood mononuclear cells, accompanied by the decreased levels of total cholesterol, low density lipoprotein, and increased ratios of high density lipoprotein to cholesterol. These may contribute to the functions of statins in the treatment of atherosclerosis. Copyright © 2017 Elsevier B.V. All rights reserved.

Effect of difference between group constants processed by codes TIMS and ETOX on integral quantities

International Nuclear Information System (INIS)

Takano, Hideki; Ishiguro, Yukio; Matsui, Yasushi.

1978-06-01

Group constants of 235 U, 238 U, 239 Pu, 240 Pu and 241 Pu have been produced with the processing code TIMS using the evaluated nuclear data of JENDL-1. The temperature and composition dependent self-shielding factors have been calculated for the two cases with and without considering mutual interference resonant nuclei. By using the group constants set produced by the TIMS code, the integral quantities, i.e. multiplication factor, Na-void reactivity effect and Doppler reactivity effect, are calculated and compared with those calculated with the use of the cross sections set produced by the ETOX code to evaluate accuracy of the approximate calculation method in ETOX. There is much difference in self-shielding factor in each energy group between the two codes. For the fast reactor assemblies under study, however, the integral quantities calculated with these two sets are in good agreement with each other, because of eventual cancelation of errors. (auth.)

DEFORMACION CORTICAL Y PELIGRO SISMICO ASOCIADO A LA FALLA SAN RAMON EN EL FRENTE CORDILLERANO DE SANTIAGO, CHILE CENTRAL (33°S)

OpenAIRE

RAULD PLOTT, RODRIGO ANDRES; RAULD PLOTT, RODRIGO ANDRES

2011-01-01

1) El orógeno Andino es fundamentalmente bi-vergente, incluyendo un gran sistema de fallas inversas cabalgantes en el frente occidental chileno, que son sintéticas con respecto al acoplamiento tectónico causante de la orogenia Andina (subducción de la placa Nazca, oceánica, bajo la placa Sudamericana, continental); 2) El funcionamiento del Cabalgamiento Andino Occidental (West Andean Thrust, WAT), documentado por la estructura con vergencia oeste de la Cordillera Principal en Chile, tiene ...

Head as metaphor in Paul

Directory of Open Access Journals (Sweden)

A. Wolters

2011-06-01

Full Text Available Since the 1980s there has been a debate among New Testament scholars about the meaning of the Greek word “kephalē” (“head” in the Pauline epistles. Some scholars defend the traditional view that it means “leader”, while others argue that it should be understood to mean “source”. One result of this debate is that it is now clear that both the traditional and the new interpretation of kephalē have very little support in general Greek usage before the New Testament. This article seeks to advance the debate by showing that the phenomenon of “semantic borrowing” can explain why the meaning “source” is effectively limited to one passage in Herodotus,and the meaning “leader” is only found in Greek works written by bilingual Jews. The passage in Herodotus probably reflects a semantic loan from Old Persian *sar while various places in the Septuagint, Philo, Josephus and Paul reflect a semantic loan from Hebrew “ro’sh” (or Aramaic “re’sh”. Because the latter semantic loan (“head” meaning “leader” is embedded in the Greek Bible (both in the Septuagint and Paul,the authority and prestige of the latter can account for the fact that the new meaning of kephalē, though unknown in previous pagan Greek writings, gradually became widespread in postbiblical Greek as Christianity spread.

TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens

Directory of Open Access Journals (Sweden)

Yoshihisa Hiraishi

2016-10-01

Conclusions: Our findings indicate that, in mice, TIM-3 is not essential for development of HDM-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM-induced chronic allergic airway inflammation.

SISTEMA DE FALLAS DE CALIDAD: ESTUDIO DE CASO CON UN ENFOQUE DE GESTIÓN DEL CONOCIMIENTO

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Gerardo Sánchez Schmitz

2004-03-01

Full Text Available

El presente estudio de caso se desarrolló en el Departamento de Calidad en una de las empresas comercializadoras de carne más importantes de México, ubicada en Hermosillo, Sonora, al noroeste de México. El objetivo de este trabajo es presentar la solución a un problema de manejo de información de fallas de calidad documentadas en el Departamento de Control de Calidad, utilizando el enfoque de gestión del conocimiento mediante el desarrollo de una memoria organizacional, para darle una solución más rápida a las reclamaciones de los clientes (internos y externos.

Kunstnikuraamatud / Paul Kuimet, Dénes Kalev Farkas, Laura Kuusk ; intervjueerinud Laura Kuusk, Kristel Schwede

Index Scriptorium Estoniae

Kuimet, Paul, 1984-

2016-01-01

Paul Kuimet, Dénes Kalev Farkas ja Laura Kuusk räägivad, kuidas valmisid nende kunstnikuraamatud ja mis oli projekti tõukejõuks. Paul Kuimeti fotoraamat "In Vicinity", Dénes Kalev Farkasi raamatud "Evident in Advance" ja "Credo", Laura Kuuse raamat "Pop-up-book"

Capítulo 6. Selección de los candidatos para el ingreso a las clínicas de falla cardiaca

OpenAIRE

Arias, Carlos A.; Castellanos, Jeffrey

2016-01-01

Introducción: Las unidades de insuficiencia cardiaca son una estrategia de atención de buena calidad y con altos estándares de costo-efectividad, con impacto en la calidad de vida, aumento de la supervivencia y disminución de las rehospitalizaciones y de los costos en una patología con impacto en la salud pública. Objetivo: Formular estrategias que ayuden a definir la población que se beneficia del seguimiento en las Clínicas de falla cardiaca. Metodología: Revisión narrativa de la lite...

Science in culture the life of Paul Dirac

CERN Multimedia

Abbott, A

2000-01-01

The life of Paul Dirac has been used as the theme of a show held underground at the Delphi experiment at CERN. The 'Oracle of Delphi' was created as an outreach project and has been extremely successful (1 p).

Fallas del mercado de la salud en Colombia: el caso de la insuficiencia renal crónica

Directory of Open Access Journals (Sweden)

Chicaíza , Liliana

2005-06-01

Full Text Available La insuficiencia renal crónica es una de las patologías de alto costo con mayor impacto financiero para el Sistema General de Seguridad Social en Salud de Colombia. La alta concentración de casos de alto costo en algunas empresas del sector hizo necesaria la redistribución de recursos y pacientes para contrarrestar el desequilibrio financiero. El artículo señala que la inducción a la demanda es la principal falla de este mercado oligopólico. Expone algunas hipótesis sobre los incentivos de las empresas y muestra que la entidad reguladora debe intervenir en el control de los precios y la calidad y, sobre todo, adaptar medidas orientadas a prevenir la enfermedad.

Paul Voosen Receives 2013 David Perlman Award for Excellence in Science Journalism—News: Citation

Science.gov (United States)

Zaneski, Cyril T.

2014-01-01

It's my pleasure to nominate Paul Voosen, the former science reporter for Greenwire, for the David Perlman award. Last November, as Superstorm Sandy pounded the East Coast of the United States, Paul found himself stranded for several days in Miami, mourning a recently deceased family member.

IL-15 induces strong but short-lived tumor-infiltrating CD8 T cell responses through the regulation of Tim-3 in breast cancer

Energy Technology Data Exchange (ETDEWEB)

Heon, Elise K. [University of Maryland Medical Center, Baltimore, MD 21201 (United States); Wulan, Hasi [Department of Plastic and Reconstructive Surgery, PLA General Hospital, Beijing, 100853 (China); Macdonald, Loch P.; Malek, Adel O.; Braunstein, Glenn H.; Eaves, Connie G.; Schattner, Mark D. [Brown University, Providence, RI 02912 (United States); Allen, Peter M.; Alexander, Michael O.; Hawkins, Cynthia A.; McGovern, Dermot W.; Freeman, Richard L. [University of Wisconsin, Madison, WI 53706 (United States); Amir, Eitan P.; Huse, Jason D. [University of Illinois, Chicago, IL 60607 (United States); Zaltzman, Jeffrey S.; Kauff, Noah P.; Meyers, Paul G. [University of Texas, Austin, TX 78712 (United States); Gleason, Michelle H., E-mail: GleasonM@cblabs.org [University of Texas, Austin, TX 78712 (United States); Overholtzer, Michael G., E-mail: OverholtzerM@cblabs.org [University of Texas, Austin, TX 78712 (United States); Wiseman, Sam S. [Ohio State University, Columbus, OH 43210 (United States); and others

2015-08-14

IL-15 has pivotal roles in the control of CD8{sup +} memory T cells and has been investigated as a therapeutic option in cancer therapy. Although IL-15 and IL-2 share many functions together, including the stimulation of CD8 T cell proliferation and IFN-γ production, the different in vivo roles of IL-15 and IL-2 have been increasingly recognized. Here, we explored the different effects of IL-15 and IL-2 on tumor-infiltrating (TI) T cells from resected breast tumors. We found that neither IL-2 nor IL-15 induced intratumoral CD8 T cell proliferation by itself, but after CD3/CD28-stimulation, IL-15 induced significantly higher proliferation than IL-2 during early time points, at day 2, day 3 and day 6. However, the IL-15-induced proliferation leveled off at day 9 and day 12, whereas IL-2 induced lower but progressive proliferation at each time point. Furthermore, IL-15 caused an early and robust increase of IFN-γ in the supernatant of TI cell cultures, which diminished at later time points, while the IL-2-induced IFN-γ production remained constant over time. In addition, the IL-15-costimulated CD8 T cells presented higher frequencies of apoptotic cells. The diminishing IL-15-induced response was possibly due to regulatory and/or exhaustion mechanisms. We did not observe increased IL-10 or PD-1 upregulation, but we have found an increase of Tim-3 upregulation on IL-15-, but not IL-2-stimulated cells. Blocking Tim-3 function using anti-Tim-3 antibodies resulted in increased IL-15-induced proliferation and IFN-γ production for a prolonged period of time, whereas adding Tim-3 ligand galectin 9 led to reduced proliferation and IFN-γ production. Our results suggest that IL-15 in combination of Tim-3 blocking antibodies could potentially act as an IL-2 alternative in tumor CD8 T cell expansion in vitro, a crucial step in adoptive T cell therapy. - Highlights: • We explored the effects of IL-15 and IL-2 on tumor-infiltrating (TI) T cells of breast cancer. • IL-15

76 FR 73666 - Notice of Inventory Completion: Paul H. Karshner Memorial Museum, Puyallup, WA

Science.gov (United States)

2011-11-29

..., 2011. ADDRESSES: Brian Fox, Director of Instructional Leadership, Puyallup School District, Paul H... American. Pursuant to 25 U.S.C. 3001(2), a relationship of shared group identity cannot be reasonably... criteria in 43 CFR 10.11(c)(1) should contact Brian Fox, Director of Instructional Leadership, Paul H...

Approaches to vegetation mapping and ecophysiological hypothesis testing using combined information from TIMS, AVIRIS, and AIRSAR

Science.gov (United States)

Oren, R.; Vane, G.; Zimmermann, R.; Carrere, V.; Realmuto, V.; Zebker, Howard A.; Schoeneberger, P.; Schoeneberger, M.

1991-01-01

The Tropical Rainforest Ecology Experiment (TREE) had two primary objectives: (1) to design a method for mapping vegetation in tropical regions using remote sensing and determine whether the result improves on available vegetation maps; and (2) to test a specific hypothesis on plant/water relations. Both objectives were thought achievable with the combined information from the Thermal Infrared Multispectral Scanner (TIMS), Airborne Visible/Infrared Imaging Spectrometer (AVIRIS), and Airborne Synthetic Aperture Radar (AIRSAR). Implicitly, two additional objectives were: (1) to ascertain that the range within each variable potentially measurable with the three instruments is large enough in the site, relative to the sensitivity of the instruments, so that differences between ecological groups may be detectable; and (2) to determine the ability of the three systems to quantify different variables and sensitivities. We found that the ranges in values of foliar nitrogen concentration, water availability, stand structure and species composition, and plant/water relations were large, even within the upland broadleaf vegetation type. The range was larger when other vegetation types were considered. Unfortunately, cloud cover and navigation errors compromised the utility of the TIMS and AVIRIS data. Nevertheless, the AIRSAR data alone appear to have improved on the available vegetation map for the study area. An example from an area converted to a farm is given to demonstrate how the combined information from AIRSAR, TIMS, and AVIRIS can uniquely identify distinct classes of land use. The example alludes to the potential utility of the three instruments for identifying vegetation at an ecological scale finer than vegetation types.

78 FR 46938 - St. Paul Park Refining Co. LLC v. Enbridge Pipelines (North Dakota) LLC; Notice of Complaint

Science.gov (United States)

2013-08-02

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. OR13-28-000] St. Paul Park..., 2013, St. Paul Park Refining Co. LLC (Complainant) filed a formal complaint against Enbridge Pipelines... regulatory basis. St. Paul Park Refining Co. LLC certifies that copies of the complaint were served on the...

Falla de Ramón: análisis de las noticias aparecidas en la prensa. / Ramon failure: analysis of reports in the press

Directory of Open Access Journals (Sweden)

Ferrando A., Francisco J.

2002-07-01

Full Text Available Durante los primeros meses del presente año aparecieron en la prensa una serie de informaciones sobre la "Falla San Ramón", o más bien "Falla de Ramón" (Börgel. El Mercurio 18/3/02. En ellas se presentan omisiones y contradicciones que pueden llevar a crear alarmismo y desconcierto en términos económicos, sociales y psicológicos, por lo cual la Sociedad Chilena de Ciencias Geográficas por intermedio del Prof. F. Ferrando A., Director de la Escuela de Geografía, F.A.U., de la Universidad de Chile considera pertinente discutir y aclarar algunos aspectos e incorporar otros antecedentes./ In the beginning of this year there were many news articles concerning the San Ramon Fault or Ramon Fault (Börgel, El Mercurio, March 18, 2002. In these articles there are contradictions and omissions that may result in confusion or panic in an economic, social and/or psychological sense. This is why the Sociedad Chilena de Ciencias Geográficas (Chilean Society of Geographic Science through the professor F. Ferrando A. Director of the Geography School, F.A.U. , of the University of Chile, advices the discussion and clarification of some matters concerning the San Ramon Fault and also take new information on account.

Modern historical epistemology through the prism of Paul Ricoeur’ transactions

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Trubnikova Natalia

2016-01-01

Full Text Available In this article it is carried out the contribution of Paul Ricoeur, the leading theorist of modern humanitarian knowledge, in the elaboration of the modern historical epistemology problems. His diverse works affect all sense fields of history and historical perception. The article shows the place of Paul Ricoeur as a primary guide of philosophical hermeneutic tradition achievements in the sphere of historical research, moreover, as a thinker, who gives a principal possibility to surmount divisions of different historiographical trends and find a methodological consensus in regard to basic orientations of historical scholarship. On the basis of his works the dialectic of a historical objectivity and a personal subjectivity of historian, the interoperability issues of history and historical memory are traced. At the same time this paper touches principals dichotomies, basic for the Paul Ricoeur’s considerations, such as fiction and historical narration, structure and event, history and truth, memory and imagination, scientism and art of interpretation, human action and social constraint. The contents of a current debate on the theory of history, based on the development of the Ricoeur’s “defatalisation” of history concept and utopian future vision are shown.

Método basado en clasificadores k-NN parametrizados con algoritmos genéticos y la estimación de la reactancia para localización de fallas en sistemas de distribución.

Directory of Open Access Journals (Sweden)

Andrés Zapata-Tapasco

2014-01-01

Full Text Available En este artículo se presenta una estrategia de parametrización de un localizador de fallas basado en una técnica simple pero eficiente de aprendizaje, conocida como k vecinos más cercanos (k-NN. Esta técnica se complementa con un método plenamente probado de localización basado en la estimación de la impedancia de falla. La estrategia híbrida se validó en un circuito prototipo real, con resultados de error aceptables para aplicaciones en sistemas de distribución de energía eléctrica. Finalmente y como ventaja importante de la metodología propuesta se resalta la facilidad de implementación, cuando se trata de circuitos de distribución reales (más de 100 nodos.

The Filmmaker as Humanist: An Interview with Tim Robbins on the Making of "Cradle Will Rock".

Science.gov (United States)

Mason, Terrence C.

2000-01-01

Presents an interview with Tim Robbins that focuses on the making of the film "Cradle Will Rock." Robbins offers his perspectives on issues such as the power of art to convey important social messages and sources of violence in schools. Includes resources for teachers. (CMK)

Alliksaar: rohkem kui legend / Paul-Eerik Rummo

Index Scriptorium Estoniae

Rummo, Paul-Eerik, 1942-

2010-01-01

Artur Alliksaare avaldusest, mis pärineb tema toimikust (NSVL Justiitsministeeriumi parandusliku töö laagrite režiimi- ja operatiivosakonna toimik nr. 5348). Avalduses annab Artur Alliksaar end üles kui Saksa sõjaväe vabatahtliku. Vt ka Paul-Eerik Rummo artiklit "Artur Alliksaare dokumenteeritud legend" ajakirjas Keel ja Kirjandus, 2003, nr. 4.

Paul W. Kruse (1927-2012), In Memoriam

Science.gov (United States)

Reine, Marion B.; Norton, Paul R.; Stelzer, Ernie L.

2013-06-01

During his distinguished 37-year career as a research physicist at the Honeywell Research Center in Minneapolis, Minnesota, Dr. Paul W. Kruse (1927-2012) played leadership roles in two disruptive infrared detector technologies, the narrow-gap semiconductor alloy HgCdTe and the silicon CMOS-based microbolometer array, both of which revolutionized the worldwide infrared detector industry. He served on numerous government advisory boards and panels, including the Army Scientific Advisory Panel and the Army Science Board, for which he received the Outstanding Civilian Service Medal. After retiring for Honeywell in 1993, he remained active in the infrared detector field in several roles: as a successful small-business entrepreneur, as an author of two books, and as a SPIE lecturer. His books, papers and lectures have educated new generations of workers in the infrared detector industry. His career, a model for industrial research physicists, has had major and permanent impacts on the worldwide infrared detector industry. This paper is a summary of the career of Paul W. Kruse, as well as a tribute to that career and its lasting legacy.

Feasibility Report. Mississippi River at Saint Paul, Minnesota. Reevaluation of Saint Paul Flood Control Project.

Science.gov (United States)

1981-09-01

formal consultation process should be initiated. This should be done by writing to the Regional Director, U. S. Fish and Wildlife Service, Federal...16 5 FC.F PIPFRiF G;~IPHFiTIOtl LAYEP THIi>.NE*:7. 12. Ilit HES’ PERCENT LI’THTEP LIfIIT:- OFTfE B:Y WJEIGHT (JE,: I GHT LI. 15 12 wRITE FUAJLT- OIF...Paul to 8 inches in the headwaters. Cold weather nearly halted snow ielt runoff during the latter part of March, allowing many streams to drop below

Efecto de un programa de rehabilitación cardiaca basado en ejercicio sobre la capacidad física, la función cardiaca y la calidad de vida, en pacientes con falla cardiaca

Directory of Open Access Journals (Sweden)

Diana S. Atehortúa, MD

2011-01-01

Conclusión: Los pacientes con falla cardiaca que se intervienen con un programa de rehabilitación cardiaca basada en ejercicio durante doce semanas, mejoran su capacidad funcional, la función sistólica y la calidad de vida.

El De imaginibus caelestibus de Ibn al-Ḥātim

OpenAIRE

Oliveras, Marc

2009-01-01

En 1987 K. Lippincott y D. Pingree publicaron una primera edición latina junto a una traducción inglesa del tratado bilingüe árabo-latino del s. XV De imaginibus caelestibus, escrito originariamente por el andalusí Ibn al-Ḥātim en el s. X. El trabajo que se presenta aquí pretende completar al precedente con una edición del texto árabe, su traducción al español y añadir algunas interpretaciones a las posibles fuentes de la imaginería talismánica. En este breve tratado de astromagia, Ibn al-Ḥāt...

77 FR 41168 - Marine Mammals; Subsistence Taking of Northern Fur Seals; St. Paul Island

Science.gov (United States)

2012-07-12

... Administrative Procedure Act (APA). The Pribilof Island Community of St. Paul Island, Aleut Community of St. Paul... comment on from the resulting list and click on the ``Submit a Comment'' icon on the right of that line... Adobe PDF file formats only. Information related to the request for rulemaking is available on the...

Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis.

Science.gov (United States)

Fleury, Michelle; Belkina, Anna C; Proctor, Elizabeth A; Zammitti, Christopher; Simms, Robert W; Lauffenburger, Douglas A; Snyder-Cappione, Jennifer E; Lafyatis, Robert; Dooms, Hans

2018-04-01

Immune dysfunction is an important component of the disease process underlying systemic sclerosis (SSc), but the mechanisms contributing to altered immune cell function in SSc remain poorly defined. This study was undertaken to measure the expression and function of the coinhibitory receptors (co-IRs) programmed cell death 1 (PD-1), T cell immunoglobulin and ITIM domain (TIGIT), T cell immunoglobulin and mucin domain 3 (TIM-3), and lymphocyte activation gene 3 (LAG-3) in lymphocyte subsets from the peripheral blood of patients with SSc. Co-IR expression levels on subsets of immune cells were analyzed using a 16-color flow cytometry panel. The functional role of co-IRs was determined by measuring cytokine production after in vitro stimulation of SSc and healthy control peripheral blood mononuclear cells (PBMCs) in the presence of co-IR-blocking antibodies. Supernatants from cultures of stimulated PBMCs were added to SSc fibroblasts, and their impact on fibroblast gene expression was measured. Mathematical modeling was used to reveal differences between co-IR functions in SSc patients and healthy controls. Levels of the co-IRs PD-1 and TIGIT were increased, and each was coexpressed, in distinct T cell subsets from SSc patients compared to healthy controls. Levels of TIM-3 were increased in SSc natural killer cells. PD-1, TIGIT, and TIM-3 antibody blockade revealed patient-specific roles of each of these co-IRs in modulating activation-induced T cell cytokine production. In contrast to healthy subjects, blockade of TIGIT and TIM-3, but not PD-1, failed to reverse inhibited cytokine production in SSc patients, indicating that enhanced T cell exhaustion is present in SSc. Finally, cytokines secreted in anti-TIM-3-treated PBMC cultures distinctly changed the gene expression profile in SSc fibroblasts. The altered expression and regulatory capacity of co-IRs in SSc lymphocytes may contribute to disease pathophysiology by modulating the cytokine-mediated cross-talk of

TIMS-1: a processing code for production of group constants of heavy resonant nuclei

International Nuclear Information System (INIS)

Takano, Hideki; Ishiguro, Yukio; Matsui, Yasushi.

1980-09-01

The TIMS-1 code calculates the infinitely dilute group cross sections and the temperature dependent self-shielding factors for arbitrary values of σ 0 and R, where σ 0 is the effective background cross section of potential scattering and R the ratio of the atomic number densities for two resonant nuclei if any. This code is specifically programmed to use the evaluated nuclear data file of ENDF/B or JENDL as input data. In the unresolved resonance region, the resonance parameters and the level spacings are generated by using Monte Carlo method from the Porter-Thomas and Wigner distributions respectively. The Doppler broadened cross sections are calculated on the ultra-fine lethargy meshes of about 10 -3 -- 10 -5 using the generated and resolved resonance parameters. The effective group constants are calculated by solving the neutron slowing down equation with the use of the recurrence formula for the neutron slowing down source. The output of the calculated results is given in a format being consistent with the JAERI-Fast set (JFS) or the Standard Reactor Analysis Code (SRAC) library. Both FACOM 230/75 and M200 versions of TIMS-1 are available. (author)

78 FR 76143 - Proposed CERCLA Settlement Relating to the Paul's Tank Cleaning Service Superfund Site...

Science.gov (United States)

2013-12-16

... Paul's Tank Cleaning Service Superfund Site, Burlington County, New Jersey AGENCY: Environmental.... (``Settling Party''). The Settling Party is a potentially responsible party, pursuant to Section 107(a) of CERCLA, and thus is potentially liable for response costs incurred at or in connection Paul's Tank...

Hermeneutics in identity formation: Paul's use of Genesis in ...

African Journals Online (AJOL)

Test

2010-08-06

Aug 6, 2010 ... psychological functioning and large-scale social processes .... the Christian's life of service to God as a spiritual battle; however, military terms dominate .... subscribes to Dunn's thesis that Paul's law-polemic addressed Jewish ...

The Urgency for Peace in Teachings of John Paul II

Directory of Open Access Journals (Sweden)

Jerzy Lewandowski

2014-04-01

Full Text Available Peace has always been a topic of great importance. Its presence is desired by all nations and societies. It brings the world together in unity. John Paul II considered peace to be an integral part in creation of an independent and healthy society. Papal encyclicals and messages, intended to present the response of the teaching Church to problems that arise from time to time, often dwell on the principles that advocate peace. Since freedom and peace are in many cases a privilege for many nations, the mentioned pope commits himself to speak about the cruelty and evilness of wars and national conflicts. Pope John Paul II denounces intolerance as denial of freedom for many people, and consequently a great threat to peace. The pope teaches that peace has its roots in the family. Yet, in many societies, the family is deprived of the utmost importance that it certainly deserves. Without the adequate means for a decent livelihood, families can experience hardship in committing themselves to promote solidarity and a proper social fabric worthy of human dignity. For John Paul II, a nation’s freedom and peace are safeguarded and promoted through particular attention and a much-devoted effort by strong and healthy families.

Paul Goodman Redux: Education as Apprenticed Anarchism

Science.gov (United States)

Holowchak, M. Andrew

2010-01-01

When talk of philosophy of pedagogy comes up today, it is common to hear the names of Aristotle, Thomas Jefferson, John Dewey, or Paulo Freire, but the name of Paul Goodman, who campaigned vigorously for pedagogical reform much of his life, is seldom mentioned. In spite of neglect of his work, Goodman had much to say on pedagogical practice that…

Ontology and anthropology of interanimality: Merleau-Ponty from Tim ingold's perspective

Directory of Open Access Journals (Sweden)

Ana Cristina Ramírez Barreto

2010-01-01

Full Text Available This essay explores Tim Ingold’s anthropological theory following his references to Merleau-Ponty and the concept of interanimality/interagentivity. It poses some ideas of Ingold’s “poetics of dwelling”, which he highlights from ethnographies of hunter-gatherer peoples, and how these ideas are linked to an ontological consideration which does not dissociate body and person, body and mind, nature and culture, animality and humanity. The paper reviews animal literature in Merleau-Ponty’s philosophy, and Ingold’s critique of “Anthropology of the senses”. It also gives critical clues for the ethical and political implications of this ontology.

Sand flies in Timóteo, Minas Gerais, Brazil (Diptera: Psychodidae)

OpenAIRE

Andrade Filho, José Dilermando; Carneiro, Ana Paula Salgado; Lima, Mauro Lucio Nascimento; Santiago, Rodrigo Martins; Gama, Marco Antônio; Santos, Carlos Alberto; Falcão, Alda Lima; Brazil, Reginaldo Peçanha

1997-01-01

Casos esporádicos de leishmaniose tegumentar têm ocorrido no Município de Timóteo, Minas Gerais, basicamente na população rural. Para conhecer a fauna de flebotomíneos da região, foram instaladas sete armadilhas luminosas de New Jersey na cidade, em sete diferentes bairros. As coletas foram realizadas no período de junho a outubro de 1994, dezembro de 1994 e janeiro a março de 1995, com um total de 3.240 horas por armadilha. Foram capturados 4.396 flebotomíneos, distribuídos em dois gêneros e...

Acute myeloid leukemia stem cell markers in prognosis and targeted therapy: potential impact of BMI-1, TIM-3 and CLL-1.

Science.gov (United States)

Darwish, Noureldien H E; Sudha, Thangirala; Godugu, Kavitha; Elbaz, Osama; Abdelghaffar, Hasan A; Hassan, Emad E A; Mousa, Shaker A

2016-09-06

Acute myeloid leukemia (AML) patients show high relapse rates and some develop conventional chemotherapy resistance. Leukemia Stem Cells (LSCs) are the main player for AML relapses and drug resistance. LSCs might rely on the B-cell-specific Moloney murine leukemia virus integration site-1 (BMI-1) in promoting cellular proliferation and survival. Growth of LSCs in microenvironments that are deprived of nutrients leads to up-regulation of the signaling pathways during the progression of the disease, which may illustrate the sensitivity of LSCs to inhibitors of those signaling pathways as compared to normal cells. We analyzed the expression of LSC markers (CD34, CLL-1, TIM-3 and BMI-1) using quantitative RT-PCR in bone marrow samples of 40 AML patients of different FAB types (M1, M2, M3, M4, M5, and M7). We also studied the expression of these markers in 2 AML cell lines (Kasumi-1 and KG-1a) using flow cytometry and quantitative RT-PCR. The overexpression of TIM-3, CLL-1, and BMI-1 was markedly correlated with poor prognosis in these patients. Our in vitro findings demonstrate that targeting BMI-1, which markedly increased in the leukemic cells, was associated with marked decrease in leukemic burden. This study also presents results for blocking LSCs' surface markers CD44, CLL-1, and TIM-3. These markers may play an important role in elimination of AML. Our study indicates a correlation between the expression of markers TIM-3, CLL-1, and especially of BMI-1 and the aggressiveness of AML and thus the potential impact of prognosis and therapies that target LSCs on improving the cure rates.

Automatic Configuration of Programmable Logic Controller Emulators

Science.gov (United States)

2015-03-01

download.php?articleid= sec v6 n12 2013 3 . [FGM+99] Roy Fielding, Jim Gettys, Jeffrey Mogul, Henrik Frystyk, Larry Masin- ter, Paul Leach, and Tim...2011 ACM SIGCOMM Conference on, IMC ’11, pages 397–412, New York, NY, USA, 2011. ACM. [LBZH13] Patrick LaRoche, Aimee Burrows , and A. Nur Zincir

A Comparative Study of Saint Paul and Fakhri Razi on Faith

Directory of Open Access Journals (Sweden)

Ghorban Elmi

2014-09-01

Full Text Available Faith has a central place in Abrahamic religions. Jewish, Christian and Moslem thinkers have conducted several studies of the notion of faith and offered different ideas. Fakhri Razi and Saint Paul, two thinkers from Islamic and Christian religious traditions, have commented on the matter at length and these comments and ideas are studied in this essay.    Paul the Apostle (died 64 AD is the most famous and influential Christian figure and is known as the second founder of Christianity. He has an indispensable role in formulating Christian doctrines. At first, he was a Jew and after the revelation of Jesus, converted to Christianity and dedicated himself to evangelism. The only credible reports and first hand sources about the lives and beliefs of Paul are the Acts of the Apostles and his letters and epistles in the Bible.    The background of the debate on faith should be sought for in the Old Testament. In the Old Testament, belief means trusting in God, relying on Him, and recognizing and acknowledging the special relationship that God has established with Israel. In the New Testament, belief has a significant position too. Faith in the New Testament is more epistemic and cognitive and means certain belief and conviction. According to Paul faith is the basic principle of Christianity and outstanding feature of Christians and the main cause of salvation. In the early Christianity, Paul offers the most extensive and most profound exposition of faith.    In defining faith, Paul uses Greek word «pistis» which means confidence, faith and trust. In definition of faith, he says: "Faith is the confidence that what we hope will be, and faith is the certainty of what we believe, although we are not able to see them "(Hebrews, 11/1. He mentions Abraham as a distinguished example for introducing true faith and faithful. Faith in Jesus means to trust or have confidence in Jesus Christ. According to Paul, faith is based on hope in things which have

A Comparative Study of Saint Paul and Fakhri Razi on Faith

Directory of Open Access Journals (Sweden)

Hamed Nazarpour najafabadi

2014-08-01

Full Text Available Faith has a central place in Abrahamic religions. Jewish, Christian and Moslem thinkers have conducted several studies of the notion of faith and offered different ideas. Fakhri Razi and Saint Paul, two thinkers from Islamic and Christian religious traditions, have commented on the matter at length and these comments and ideas are studied in this essay.    Paul the Apostle (died 64 AD is the most famous and influential Christian figure and is known as the second founder of Christianity. He has an indispensable role in formulating Christian doctrines. At first, he was a Jew and after the revelation of Jesus, converted to Christianity and dedicated himself to evangelism. The only credible reports and first hand sources about the lives and beliefs of Paul are the Acts of the Apostles and his letters and epistles in the Bible.    The background of the debate on faith should be sought for in the Old Testament. In the Old Testament, belief means trusting in God, relying on Him, and recognizing and acknowledging the special relationship that God has established with Israel. In the New Testament, belief has a significant position too. Faith in the New Testament is more epistemic and cognitive and means certain belief and conviction. According to Paul faith is the basic principle of Christianity and outstanding feature of Christians and the main cause of salvation. In the early Christianity, Paul offers the most extensive and most profound exposition of faith.    In defining faith, Paul uses Greek word «pistis» which means confidence, faith and trust. In definition of faith, he says: "Faith is the confidence that what we hope will be, and faith is the certainty of what we believe, although we are not able to see them "(Hebrews, 11/1. He mentions Abraham as a distinguished example for introducing true faith and faithful. Faith in Jesus means to trust or have confidence in Jesus Christ. According to Paul, faith is based on hope in things which have

Paul Hillieri koor tõi Eestile Grammy / Immo Mihkelson

Index Scriptorium Estoniae

Mihkelson, Immo, 1959-

2007-01-01

2006. aasta septembris ilmunud plaadifirma Harmonia Mundi heliplaadi Arvo Pärt "Da Pacem", esitab Eesti Filharmoonia Kammerkoor, dirigent Paul Hillier Grammy võidust. Eesti Filharmoonia Kammerkoori koostööst USA plaadirmaga Harmonia Mundi. Grammy võitnud heliplaadist

Application of TIMS in isotope correlations for determining the isotope ratios of plutonium

International Nuclear Information System (INIS)

Alamelu, D.; Aggarwal, S.K.

2003-01-01

Thermal ionisation mass spectrometry (TIMS) is a well-recognized technique for determining the isotopic composition of Pu in irradiated nuclear fuel samples. Other mass spectrometric methods such as ICPMS, SIMS can also be employed for the isotopic analysis of Pu. In the event of non-availability of a mass spectrometer, other techniques such as gamma spectrometry and alpha spectrometry can also be used. They have a limited applicability since data on all the Pu isotopes cannot be obtained

Response to Tim Barringer, A White Atlantic?

Directory of Open Access Journals (Sweden)

Kate Flint

2009-11-01

Full Text Available In my response to Tim Barringer’s piece, I emphasize the importance of extending one’s frame of reference when discussing transatlantic artistic connections to the consideration of as many different art forms as possible – including photography, and magazine and book illustrations – in order to get as full a picture as possible of the two-way flow in transatlantic artistic influences.This fuller picture notably extends the degree to which images of non-white subjects are seen to be in circulation. I also draw attention to the ways in which American and English artistic circles intersected outside as well as within these two countries, a point reinforced by looking at American women sculptors in Rome in the 1860s, paying particular attention to the work of the part African-American, part Native American sculptor, Edmonia Lewis. In her work can be seen a complex set of attitudes towards her subject matter that remind one forcefully of the many racial and cultural strands coming together in new American art.

Paul Graham, American Night

Directory of Open Access Journals (Sweden)

Catherine Bernard

2006-12-01

Full Text Available Le photographe britannique Paul Graham (1956- ne jouit pas encore en France de la notoriété de son compatriote Martin Parr et on ne peut, par conséquent, que se féliciter de voir l’une de ses plus puissantes séries — American Night — représentée à la Galerie Les Filles du Calvaire.Connu, avec Parr, pour avoir profondément influencé la photo documentaire anglaise en la faisant passer à la couleur avec virulence, Graham a été révélé il y a une vingtaine d’années par une série d’images prises à...

Introduction: Reappraising Paul Feyerabend.

Science.gov (United States)

Brown, Matthew J; Kidd, Ian James

2016-06-01

This volume is devoted to a reappraisal of the philosophy of Paul Feyerabend. It has four aims. The first is to reassess his already well-known work from the 1960s and 1970s in light of contemporary developments in the history and philosophy of science. The second is to explore themes in his neglected later work, including recently published and previously unavailable writings. The third is to assess the contributions that Feyerabend can make to contemporary debate, on topics such as perspectivism, realism, and political philosophy of science. The fourth and final aim is to reconsider Feyerabend's place within the history of philosophy of science in the light of new scholarship. Copyright © 2015 Elsevier Ltd. All rights reserved.

The value of children in the context of the family in Java / by Paul A. Meyer

Trove (Australia)

Meyer, Paul A

1987-01-01

... The value of children in the context of the family in Java [microform] / by Paul A. Meyer. The value of children in the context of the family in Java by Paul A. Meyer. The value of children in the context of the family in Java ...

Justice John Paul Stevens and the Erotic Boomerang.

Science.gov (United States)

Lieberman, Marc

Justice John Paul Stevens of the United States Supreme Court has ruled on obscenity cases in seven instances since his appointment. His rulings reveal that he regards obscenity as a nuisance rather than as a danger threatening to undermine the nation's morality, that he supports a nationwide standard to adjudicate obscenity cases, and that he…

Failure analysis to the weights of balance of a 350 MW turbo-generator; Analisis de falla a los pesos de balanceo de un turbogenerador de 350 MW

Energy Technology Data Exchange (ETDEWEB)

Vital Flores, Francisco; Gamero Arroyo, Jose Manuel [LAPEM, Comision Federal de Electricidad (Mexico)

2007-11-15

The selection of materials and the quality control in the supply of the components, as well as the involved operative variables in the process of work to which an equipment, device or a system of a power station of electrical generation are subjected, impact in the same in their useful life in a decisive way. In this document it is presented an analysis of a failure occurred in a 350 MW turbo-generator by the loosening of the balance weights, in which it is mentioned the flaws occurred by this cause and a metallographic analysis that indicates the main fault for the happening. [Spanish] La seleccion de material y el control de calidad en los suministros de los componentes, asi como las variables operativas involucradas en el proceso de trabajo al cual es sometido un equipo, dispositivo o un sistema de una central de generacion electrica, impactan en los mismos de manera decisiva en su vida util. En este documento se presenta un analisis de falla ocurrido en un turbogenerador de 350 MW, por el desprendimiento de los pesos de balanceo, el cual se menciona de los desperfectos ocurridos por esta causa y un analisis metalografico que indica la falla principal por lo ocurrido.

Evaluación hemodinámica no invasiva con cardiografía de impedancia: aplicaciones en falla cardíaca y en hipertensión arterial

Directory of Open Access Journals (Sweden)

Jon Kepa Balparda, MD

2012-02-01

Full Text Available La cardiografía de impendancia (CGI representa un método no invasivo para la evaluación del estado hemodinámico latido a latido. Aunque se introdujo por primera vez hace más de 40 años, la CGI ha mostrado un resurgimiento en la última década, a partir de una serie de estudios clínicos que han demostrado su precisión en la estimación del volumen latido, tanto contra el “gold-standard“invasivo (termodilución, como contra los métodos de referencia no invasivos (ecocardiografía. Diversos estudios demuestran la utilidad de esta técnica en el manejo del paciente con falla cardíaca y en el enfoque diagnóstico y terapéutico de la hipertensión arterial, por lo cual constituyen actualmente dos de las aplicaciones clínicas más importantes de la CGI. En falla cardiaca, los cambios en el volumen de líquido del tórax y del gasto cardíaco evaluados por CGI, han demostrado ser predictores de descompensación aguda, incluso semanas antes del inicio de la sintomatología respiratoria; además, permiten identificar el origen cardiogénico o respiratorio de la disnea cuando el examen físico y los demás paraclínicos no son concluyentes. En los pacientes con hipertensión arterial no controlada o resistente, la CGI permite realizar una mejor caracterización del fenotipo hipertensivo y elegir la estrategia farmacológica más específica para intervenir la alteración hemodinámica predominante (resistencia vascular vs. gasto cardiaco elevado. En este artículo se realiza una revisión de los principios biofísicos de la CGI y su utilidad en la evaluación no invasiva del estado hemodinámico, así como una evaluación crítica de la literatura que da soporte a su aplicación clínica en el tratamiento de la falla cardíaca y la hipertensión arterial.

Microfabricated linear Paul-Straubel ion trap

Science.gov (United States)

Mangan, Michael A [Albuquerque, NM; Blain, Matthew G [Albuquerque, NM; Tigges, Chris P [Albuquerque, NM; Linker, Kevin L [Albuquerque, NM

2011-04-19

An array of microfabricated linear Paul-Straubel ion traps can be used for mass spectrometric applications. Each ion trap comprises two parallel inner RF electrodes and two parallel outer DC control electrodes symmetric about a central trap axis and suspended over an opening in a substrate. Neighboring ion traps in the array can share a common outer DC control electrode. The ions confined transversely by an RF quadrupole electric field potential well on the ion trap axis. The array can trap a wide array of ions.

The command to love the neighbour in Paul and the Synoptics

Directory of Open Access Journals (Sweden)

Heinz A. Hiestermann

2016-03-01

Full Text Available When sayings of Jesus are compared between the Pauline letters and the Synoptic Gospels in an attempt to locate parallels, Galatians 5:14 and Romans 13:8�10 have frequently been put forward as possible parallels to the Synoptic renditions of the great commandment of Mark 12:28�34 (Mt 22:34�40; Lk 10:25�28. These Pauline and Synoptic texts all contain the command to love the neighbour, but the Synoptic texts have added the command to love God to the command to love the neighbour. Paul never quoted the great commandment. Consequently, a relationship between the verses is normally rejected. However, not all possibilities have been explored. In the search for parallels between Pauline and Synoptic Jesus traditions it has been overlooked that Paul and Matthew render the command to love the neighbour more than once. Matthew delivers the command to love the neighbour three times. Only once he has connected it to the command to love God. Matthew renders the single command to love the neighbour twice, resembling the Pauline use of the command. Using the criteria for validating parallels between Pauline and Synoptic Jesus traditions, including verbal agreement and the unique use of the command to love the neighbour by Paul and Matthew, it is argued that a connection between Romans 13:9 and Matthew 19:18�19 is likely.Intradisciplinary and/or interdisciplinary implications: The research explores the use of Leviticus 19:18b by the New Testament authors. It is argued that the command to love the neighbour was given high prominence in the early church, as it was used by the Synoptic authors and by Paul to summarise Jesus� ethical teachings.

Paul, military imagery and social disadvantage | Punt | Acta ...

African Journals Online (AJOL)

In the past, attention for the social position or standing of the early Jesus followers was overrun by concerns for the theological and religious dimensions of those communities. The role of the Roman Empire and the impact of its military forces on the lives of people have generated even less attention. Paul's use of military ...

Don't think about blue elephants! / Paul Hanley ; interv. Alina Lisina

Index Scriptorium Estoniae

Hanley, Paul

2005-01-01

"Guerrilla marketing'i" (partisani turundus) - hoolikalt kavandatud ja alternatiivseid kanaleid kasutav ebatraditsiooniline turundustegevus - tutvustus. Lisad: Paul Hanley; GM müüdid; 15 Guerrilla turunduse saladust

Paul Hill d/b/a Alternative Energy Windows and Siding

Science.gov (United States)

Paul Hill d/b/a Alternative Energy Windows and Siding (the Company) is located in Concord, New Hampshire. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Concord, New Hampshire.

First U.S. Web page went up 10 years ago

CERN Multimedia

Kornblum, J

2001-01-01

Wednesday marks the 10th anniversary of the first U.S. Web page, created by Paul Kunz, a physicist at SLAC. He says that if World Wide Web creator Tim Berners-Lee hadn't been so persistant that he attended a demonstration meeting on a visit to CERN, the Web wouldn't have taken off when it did -- maybe not at all.

Paul's community formation in 1 Thessalonians: The creation of ...

African Journals Online (AJOL)

2015-06-04

Jun 4, 2015 ... Cho, K., Van Eck, E. & Wepener, ... Read online: .... Paul labels as 'the gospel of God' (1 Thes 2:2, 8–9) and 'the ..... Raymond Collins (1984) .... Van Eck, E., 2011, 'Social memory and identity: Luke 19:12b–24 and 27', Biblical.

Revised Mulliken Electronegativities I. Calculation and Conversion to Pauling Units.

Science.gov (United States)

Bratsch, Steven G.

1988-01-01

Discusses a revision and extension of the Mulliken electronegativity scale to consider 50 elements. Describes the calculation of valence-state promotion energies and Mulliken atomic electronegativities and the conversion of Mulliken electronegativities to Pauling units. (CW)

AVIRIS and TIMS data processing and distribution at the land processes distributed active archive center

Science.gov (United States)

Mah, G. R.; Myers, J.

1993-01-01

The U.S. Government has initiated the Global Change Research program, a systematic study of the Earth as a complete system. NASA's contribution of the Global Change Research Program is the Earth Observing System (EOS), a series of orbital sensor platforms and an associated data processing and distribution system. The EOS Data and Information System (EOSDIS) is the archiving, production, and distribution system for data collected by the EOS space segment and uses a multilayer architecture for processing, archiving, and distributing EOS data. The first layer consists of the spacecraft ground stations and processing facilities that receive the raw data from the orbiting platforms and then separate the data by individual sensors. The second layer consists of Distributed Active Archive Centers (DAAC) that process, distribute, and archive the sensor data. The third layer consists of a user science processing network. The EOSDIS is being developed in a phased implementation. The initial phase, Version 0, is a prototype of the operational system. Version 0 activities are based upon existing systems and are designed to provide an EOSDIS-like capability for information management and distribution. An important science support task is the creation of simulated data sets for EOS instruments from precursor aircraft or satellite data. The Land Processes DAAC, at the EROS Data Center (EDC), is responsible for archiving and processing EOS precursor data from airborne instruments such as the Thermal Infrared Multispectral Scanner (TIMS), the Thematic Mapper Simulator (TMS), and Airborne Visible and Infrared Imaging Spectrometer (AVIRIS). AVIRIS, TIMS, and TMS are flown by the NASA-Ames Research Center ARC) on an ER-2. The ER-2 flies at 65000 feet and can carry up to three sensors simultaneously. Most jointly collected data sets are somewhat boresighted and roughly registered. The instrument data are being used to construct data sets that simulate the spectral and spatial

Diagnosis technique for the detection of mechanical faults in power breakers; Tecnica de diagnostico para la deteccion de fallas mecanicas en interruptores de potencia

Energy Technology Data Exchange (ETDEWEB)

Linan, Roberto; Perez, Marciano; Estrada, J. Manuel [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

1996-12-31

This article reports a non-invasive diagnosis technique for the detection of mechanical faults in power breakers, supporting it with the recording and analysis of vibration signals of the equipment under test. Also, an assessment of four breakers using this technique is presented. [Espanol] En el presente articulo se reporta una tecnica de diagnostico no invasiva para detectar fallas mecanicas en interruptores de potencia, apoyandose en el registro y analisis de senales de vibracion del equipo bajo prueba. Asimismo, se presenta la evaluacion de cuatro interruptores usando esta tecnica.

Diagnosis technique for the detection of mechanical faults in power breakers; Tecnica de diagnostico para la deteccion de fallas mecanicas en interruptores de potencia

Energy Technology Data Exchange (ETDEWEB)

Linan, Roberto; Perez, Marciano; Estrada, J Manuel [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

1997-12-31

This article reports a non-invasive diagnosis technique for the detection of mechanical faults in power breakers, supporting it with the recording and analysis of vibration signals of the equipment under test. Also, an assessment of four breakers using this technique is presented. [Espanol] En el presente articulo se reporta una tecnica de diagnostico no invasiva para detectar fallas mecanicas en interruptores de potencia, apoyandose en el registro y analisis de senales de vibracion del equipo bajo prueba. Asimismo, se presenta la evaluacion de cuatro interruptores usando esta tecnica.

The Personal Tragedy in Paul Hindemith's Mathis de Maler

Directory of Open Access Journals (Sweden)

Sharri K Hall

2018-03-01

Full Text Available Paul Hindemith is hardly remembered for his music prior to the 1940s. During the Nazi occupation of Germany in the early 20th century, Paul Hindemith, reviled for his modernistic styles and relation to his Jewish wife, was forced to emigrate out of the Third Reich for his safety. Hindemith was known for his connections to New Objectivity, Gebrachsmusik, and tonality instability placed him in the wrong realm of composition in the Nazi’s minds. As Hitler rose to power in 1933, Hindemith knew he would need a composition to prove his worth amongst the Nazis. As such, Hindemith attempted to change his tides through the composition of the opera/symphony Mathis der Maler. Mathis featured the strong tonality, German nationalism, and Romantic monumentality the Nazis were hoping for to strengthen their regime and the global understanding of German culture. However, Mathis also illustrated Hindemith’s personal pains and struggles with the Reich.

Book review: Social Research: Issues, Methods and Process, 3rd edition, by Tim May, Open University Press, 2001, ISBN 0335206123

OpenAIRE

Jones, Keith

2004-01-01

The great strength of this book by Tim May ("Social Research: Issues, Methods and Process", 3rd edition ) is its successful negotiation (perhaps navigation) of the relationships between theory and method in (social) research.

Una década de la Tarjeta de Identidad de Menores (TIM

Directory of Open Access Journals (Sweden)

Eugenia Ma. Zamora Chavarría

2013-07-01

Full Text Available El documento de identidad de las personas difiere de su derecho a la identidad, propiamente dicho; uno y otro se encuentran estrechamente relacionados y el primero tiene la virtud de acreditar, de una manera inmediata y directa, frente a la comunidad, al segundo. Este artículo ofrece una serie de reflexiones alrededor del derecho al nombre y al concepto de identidad. Se centra en el documento denominado Tarjeta de Identidad para Costarricenses de Doce a Dieciocho Años, conocida popularmente como la Ley TIM y repasa lo actuado por el Tribunal en relación con este documento.

La conversion de Paul, regards croisés Paul’s conversion. Cross perspectives

Directory of Open Access Journals (Sweden)

Elian Cuvillier

2009-09-01

Full Text Available Au plan historique, les traditions relatives à la conversion de Paul, chutant de son cheval sur le chemin de Damas, confrontent l’exégète à trois problèmes importants : y avait-il un cheval, cela se passait-il sur le chemin de Damas et était-ce bien une conversion ? Entendues avec l’humour et la distance critique nécessaires, ces trois questions constituent les trois chapitres de cet article. Le premier « Y avait-il un cheval ? » s’intéresse à l’histoire de la réception de l’épisode de la conversion de Paul, en particulier dans la peinture et la littérature. Le second « Cela se passait-il sur le chemin de Damas ? » est consacrée au récit que l’auteur du livre des Actes propose de la conversion de Paul, récit qui constitue, bien souvent, la porte d’entrée exclusive pour aborder le thème. Le troisième « Etait-ce bien une conversion ? » analyse les témoignages de l’apôtre lui-même à travers deux passages clés de ses épîtres authentiques.Historically speaking, the traditions concerning the conversion of Paul, falling from his horse on the road to Damascus, confront the exegete with three important problems : was there a horse, did it happen on the road to Damacus and was it really a conversion ? These three questions, considered with humor and critical distance, constitute the three sections of this article. The first part « Was there a horse ? » considers the history of the reception of the episode of the conversion of Paul, particularly in art and literature. The second one « Did it happen on the road to Damascus ? » is devoted to the story of the conversion of Paul proposed by the author of the book of Acts, which is very often the exclusive entrance to the discussion of this theme. The third section « Was it really a conversion ? » analyzes the account given by the apostle himself in two key passages of his authentic epistles.

Hundred Years of Cruel Love (1915-2015 Manuel de Falla, Between Classical and Popular Music

Directory of Open Access Journals (Sweden)

Michèle Dufour

2016-05-01

Full Text Available Manuel de Falla´s Cruel Love subtitled Gypsy story in two parts is a ballet with cante jondo whose premiere was given, in a first chamber version, in Madrid´s Lara Theatre in April of 1915. With only two characters on stage, the attractive gypsy Candelas and her boyfriend Carmelo who are haunted by the ghost of her previous lover, we encounter an original anti-romantic version of the relationship between love and death struggling for the liberation of the soul through that of the body, through flamenco dance and cante jondo. This work was written after a seven-year stay (1907-14 in the Paris of La Belle Époque and contributes to the renewal of nationalism in music as it has the special interest of questioning the social frontiers between “classical music” and “popular music”. The result is a both complex and popular piece in which are found synthesized such different influences as those of Felipe Pedrell, Claude Debussy and Igor Stravinski. 

76 FR 1532 - Determinations of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur...

Science.gov (United States)

2011-01-11

... of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur/Douglas PM 10... making final determinations that the Hayden, Nogales, and Paul Spur/Douglas nonattainment areas in... the Clean Air Act, that three Arizona ``moderate'' PM 10 nonattainment areas (Hayden, Nogales, and...

Stable Trapping of Multielectron Helium Bubbles in a Paul Trap

Science.gov (United States)

Joseph, E. M.; Vadakkumbatt, V.; Pal, A.; Ghosh, A.

2017-06-01

In a recent experiment, we have used a linear Paul trap to store and study multielectron bubbles (MEBs) in liquid helium. MEBs have a charge-to-mass ratio (between 10^{-4} and 10^{-2} C/kg) which is several orders of magnitude smaller than ions (between 10^6 and 10^8 C/kg) studied in traditional ion traps. In addition, MEBs experience significant drag force while moving through the liquid. As a result, the experimental parameters for stable trapping of MEBs, such as magnitude and frequency of the applied electric fields, are very different from those used in typical ion trap experiments. The purpose of this paper is to model the motion of MEBs inside a linear Paul trap in liquid helium, determine the range of working parameters of the trap, and compare the results with experiments.

Spécificité pastorale de la personnalité de Jean-Paul II selon Jean-Marie Lustiger

Directory of Open Access Journals (Sweden)

Ryszard Biernat

2011-04-01

Full Text Available Jean-Marie Lustiger admired John Paul II and he was devoted to him. They both had similar origin. The Cardinal of Paris often accompanied the pope in his pastoral visits. He perceived John Paul II as the man of Providence. He was convinced that God had prepared him to this role. Jean-Marie Lustiger emphasized the attitudes of John Paul II that attracted the attention and admiration of observers. For instance: pray, holiness, attentive pastor and good relation with young people. Jean-Marie Lustiger as an attentive observer also focused his attention on the pastoral methods of John Paul II. In his utterances he often perceived the following methods: each person was important, defense of person’s dignity, the ability to speak with each man, modern language, importance of the pastoral visits and sui generis spiritual pedagogic. Jean-Marie Lustiger noticed radical change of perspective in preaching and in pastoral action of John Paul II. According to him the pope perceived the challenges of the modern times, evaluated needs of the humanity and gave the appropriate answers. For these he did not choose politics, sociology or even anthropology as a re fl ection but addressed to the hurt human who was redeem by Jesus Christ.

Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1).

Science.gov (United States)

Ribnicky, David M; Roopchand, Diana E; Oren, Andrew; Grace, Mary; Poulev, Alexander; Lila, Mary Ann; Havenaar, Robert; Raskin, Ilya

2014-01-01

The TNO intestinal model (TIM-1) of the human upper gastrointestinal tract was used to compare intestinal absorption/bioaccessibility of blueberry anthocyanins under different digestive conditions. Blueberry polyphenol-rich extract was delivered to TIM-1 in the absence or presence of a high-fat meal. HPLC analysis of seventeen anthocyanins showed that delphinidin-3-glucoside, delphinidin-3-galactoside, delphinidin-3-arabinoside and petunidin-3-arabinoside were twice as bioaccessible in fed state, whilst delphinidin-3-(6″-acetoyl)-glucoside and malvidin-3-arabinoside were twice as bioaccessible under fasted conditions, suggesting lipid-rich matrices selectively effect anthocyanin bioaccessibility. TIM-1 was fed blueberry juice (BBJ) or blueberry polyphenol-enriched defatted soybean flour (BB-DSF) containing equivalent amounts of free or DSF-sorbed anthocyanins, respectively. Anthocyanin bioaccessibility from BB-DSF (36.0±10.4) was numerically, but not significantly, greater than that from BBJ (26.3±10.3). Ileal efflux samples collected after digestion of BB-DSF contained 2.8-fold more anthocyanins than same from BBJ, suggesting that protein-rich DSF protects anthocyanins during transit through upper digestive tract for subsequent colonic delivery/metabolism. Copyright © 2013 Elsevier Ltd. All rights reserved.

EnviroAtlas - Minneapolis/St. Paul, MN - Ecosystem Services by Block Group

Data.gov (United States)

U.S. Environmental Protection Agency — This EnviroAtlas dataset presents environmental benefits of the urban forest in 1,772 block groups in Minneapolis/St. Paul, Minnesota. Carbon attributes, temperature...

PSI Paul Scherrer Institute; PSI Institut Paul Scherrer

Energy Technology Data Exchange (ETDEWEB)

Lefrancois, M.; Pladys, D

2008-05-15

From research activities focused on civil and military uses of nuclear energy and developed after the second world war, the Paul Scherrer Institute (PSI) has been able to diversify its activities following 2 axis. First, the Gantry proton-therapy that is characterized by a compact equipment and an accurate 3-dimensional treatment of tumors (more than 260 patients have been treated by Gantry from 1996 to 2005). Secondly, new technologies in the fields of energy and transport. Nevertheless, PSI has been able to keep a high of valuation of its staff in nuclear engineering and materials that are the core of its activities. The main equipment of PSI are: -) SLS (Swiss Light Source): a synchrotron radiation source that is both a microscope and an X-ray source; -) SINQ: a neutron source based on spallation reactions; -)S{mu}S: a muon source; and -) the Philips accelerator that is used in radiochemistry and the production of isotopes used for the treatment of eye tumors. PSI has established a large cooperation with French research laboratories on issues like: nuclear reactor safety, synchrotron radiation, the transmutation of nuclear wastes, the design of a source of ultra-cold neutrons, or the development of a hydrogen-fueled light vehicle. The total budget of PSI for 2007 reached 174.2 million euros. (A.C.)

A TIMS-based method for the high precision measurements of the three-isotope potassium composition of small samples

DEFF Research Database (Denmark)

Wielandt, Daniel Kim Peel; Bizzarro, Martin

2011-01-01

A novel thermal ionization mass spectrometry (TIMS) method for the three-isotope analysis of K has been developed, and ion chromatographic methods for the separation of K have been adapted for the processing of small samples. The precise measurement of K-isotopes is challenged by the presence of ...

Designing of a Quadrupole Paul Ion Trap

Science.gov (United States)

Kiyani, Abouzar; Abdollahzadeh, M.; Sadat Kiai, S. M.; Zirak, A. R.

2011-08-01

The ion motion equation in a Paul ion trap known as Mathieu differential equation has been solved for the first time by using Runge-Kutta methods with 4th, 6th, and 8th orders. The first stability regions in az - qz plane and the corresponding qmax values were determined and compared. Also, the first stability regions of , , , ions in the Vdc - Vac plane were drown, and the threshold voltages for the ion separation was investigated.

CB2 cannabinoid receptors modulate HIF-1α and TIM-3 expression in a hypoxia-ischemia mouse model.

Science.gov (United States)

Kossatz, Elk; Maldonado, Rafael; Robledo, Patricia

2016-12-01

The role of CB2 cannabinoid receptors (CB 2 R) in global brain lesions induced by hypoxia-ischemia (HI) insult is still unresolved. The aim of this study was to evaluate the involvement of CB 2 R in the behavioural and biochemical underpinnings related to brain damage induced by HI in adult mice, and the mechanisms involved. CB 2 R knockout (KO) mice and wild-type littermates (WT) underwent permanent ligation of the left common carotid artery and hypoxia. Behavioural measurements in the rotarod, beam walking, object recognition, open field, and Irwin tests were carried out 24h, 72h and 7 days. In KO mice, more extensive brain injury was observed. Behavioural deficits in the Irwin test were observed in both genotypes; while WT mice showed progressive recovery by day 7, KO mice did not. Only KO mice showed alterations in motor learning, coordination and balance, and did not recover over time. A higher expression of microglia and astrocytes was observed in several brain areas of lesioned WT and KO mice. The possible alteration of the inflammatory-related factors HIF-1α and TIM-3 was evaluated in these animals. In both genotypes, HIF-1α and TIM-3 expression was observed in lesioned areas associated with activated microglia. However, the expression levels of these proteins were exacerbated in KO mice in several lesioned and non-lesioned brain structures. Our results indicate that CB 2 R may have a crucial neuroprotective role following HI insult through the modulation of the inflammatory-related HIF-1α/TIM-3 signalling pathway in microglia. Copyright © 2016 Elsevier B.V. and ECNP. All rights reserved.

75 FR 67220 - Determinations of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur...

Science.gov (United States)

2010-11-02

... of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur/Douglas PM 10...: EPA has determined that the Hayden, Nogales, and Paul Spur/ Douglas nonattainment areas in Arizona... of a review of more recent ambient monitoring data, EPA has determined that the Hayden, Nogales, and...

On the Use of 233U-236U Double-Spike for TIMS Measurements of Uranium Isotopes: A Simulation Study

International Nuclear Information System (INIS)

Williams, R W

2004-01-01

Synthetic ion beams with instantaneous and temporal characteristics appropriate to thermal ionization mass spectrometry (TIMS) were mathematically generated and analyzed to determine the effects of using a mixed 233 U- 236 U spike (double-spike) in the analysis of uranium isotopes. The instantaneous beam characteristics are the intensities (e.g., counts per second) modeled with a Poisson distribution plus a component of random noise that simulates the detection processes. Several beam intensity and mass fractionation vs. time functions were modeled to simulate a range of sample sizes and the commonly employed methods of data collection. These beam profiles were also generated with different noise levels, and signal-to-noise vs. analytical precision diagrams are presented. Modeling focused on natural uranium, where 238 U/ 235 U = 137.88, and on the ability of a given method to determine precisely and accurately small variations in this ratio. Practical limits on precision were determined to be 20-30 ppm, which is consistent with precision seen for other elements by state-of-the-art TIMS. The TIMS total evaporation method was compared directly with the double-spike method. While similar analytical precisions are obtained with either method, the double-spike method of correcting for analytical bias gives more accurate results. The results of a total evaporation analysis will deviate from true by more than the analytical precision if as little as 0.05% of the signal is not integrated, whereas the accuracy and precision of the double-spiked analyses are always linked

The research contributions of Dr. Paul Van Deusen

Science.gov (United States)

Thomas B. Lynch; Francis A. Roesch; John Paul McTague; Jeffrey H. Gove; Gregory A. Reams; Aaron R. Weiskittel

2015-01-01

Dr. Paul Van Deusen’s recent passing concluded a rich 30+-year research career dedicated to development and implementation of quantitative methods for forestry and natural resources. Since the early part of his career as a biometrician with the USDA Forest Service Southern Research Station in the 1980s-1990s and continuing with his later employment at NCASI, Dr. Van...

The decapod and stomatopod Crustacea of St Paul's Rocks

NARCIS (Netherlands)

Holthuis, L.B.

1980-01-01

INTRODUCTION Saint Paul's Rocks (Penedos de São Pedro e São Paulo) are a small group of rocky islets on the mid-Atlantic ridge near the equator, occupying an area of roughly 250 by 425 m. There is no vegetation and, apart from birds and invertebrates, the islands are uninhabited. The Cambridge

John Paul II in the face of the reality of Auschwitz

Directory of Open Access Journals (Sweden)

Stanisław Wronka

2014-06-01

Full Text Available In the context of the canonization of John Paul II, the author reflects on his experience of the concentration camp at Auschwitz. It is a difficult experience, therefore it can more reveal the Pope as a man and a pastor, his way of thinking and perceiving reality. Through canonization this way is indicated to us as a pattern. John Paul came often to Auschwitz, where he saw the place of denial of God and man, but also a place of victory of man over contempt, hatred and death through faith in God, which generates love for Him and for man. The symbol of such a victory is St. Maximilian Maria Kolbe, martyr of love that as Christ gave his life for the fellow prisoner Francis Gajowniczek. In this heroic deed – in the opinion of the Pope – Christ himself was present, so the camp at Auschwitz is not only hell on earth, but also the Golgotha of our times, the cemetery of the martyrs, the sanctuary of the patron of difficult century. Pope John Paul II arrived there to pray and make a reflection on the contemporary man’s condition, who in Christ the Redeemer can still conquer evil with good and to build the peace based on respect for the rights of person and nations.

Submarine earthquake rupture, active faulting and volcanism along the major Liquiñe-Ofqui Fault Zone and implications for seismic hazard assessment in the Patagonian Andes Ruptura sísmica submarina, tectónica y volcanismo activo a lo largo de la Falla Liquiñe-Ofqui e implicancias para el peligro sísmico en los Andes patagónicos

Directory of Open Access Journals (Sweden)

Gabriel Vargas

2013-01-01

faults. Besides, seismic hazard assessment should also consider the possibility of earthquake magnitude in the order of 7.1 along the main fault systems like the RCF.La Zona de Falla Liquiñe-Ofqui es un sistema de intraarco activo y paralelo al contacto entre las placas tectónicas de Nazca y Sudamérica, a lo largo del cual el fallamiento y el volcanismo cuaternarios están estrechamente asociados. A partir de observaciones geomorfológicas y estructurales subaéreas, la prospección subacuática de fallas con evidencia de actividad pleistocena tardía-holocena y la caracterización de volcanes monogenéticos, se propone una cartografía y un modelo cinemático para la tectónica reciente, con énfasis en los últimos 12.000 años, asociada a fallas activas en el área del Fiordo Aysén. Esto permite incrementar sustancialmente el conocimiento geológico básico necesario para la determinación del peligro sísmico asociado a estructuras corticales en la región de Aysén de la Patagonia del sur de Chile. La cartografía de fallas junto con observaciones de campo y resultados geocronológicos sugieren que la deformación ocurre dominantemente a lo largo de estructuras de rumbo dextral-inversa de orientación norte-sur y localmente NNW-SSE, junto con fallas dextral-normal de rumbo NE a NNE y en menor medida a lo largo de fallas sinistrales de rumbo este-oeste. Es posible asociar esta cinemática a un acortamiento regional de orientación NE-SW. El volcanismo monogenético y subacuático holoceno ha ocurrido bajo este régimen tectónico, posiblemente favorecido por la geometría, estructura y cinemática de las fallas activas. Escarpes submarinos bien preservados de fallas que deforman sedimentos del fondo del fiordo Aysén fueron asociados con el terremoto de abril del año 2007, de magnitud Mw6,2, ocurrido a lo largo de la Zona de Falla Liquiñe-Ofqui. Observaciones realizadas en este estudio muestran que este terremoto ocurrió a lo largo de una falla de 15-20 km de

Diseño de un sistema de análisis temporal y espectral para detectar fallas por vibración en motores eléctricos

Directory of Open Access Journals (Sweden)

Francisco Ernesto Moreno-García

2014-12-01

Full Text Available El documento se basa en el desarrollo experimental de un sistema de medición y análisis de vibraciones para brindar un estudio de las más relevantes variables utilizadas en el análisis espectral de motores eléctricos, con el fin de detectar posibles fallas. Dicho sistema de análisis fue implementado en un banco de pruebas elaborado por el Grupo de Investigación en Automatización y Control (GIAC, de la Universidad Francisco de Paula Santander.

Valuable books from the library of Paul Gore (Identification and/or inventory of sources

Directory of Open Access Journals (Sweden)

Maria Danilov

2013-12-01

Full Text Available Paul Gore (1875-1927 - an outstanding figure of the socio-political, scientific and cultural life of Bessarabia at the beginning of 20th century, was also known among his contemporaries as a keen collector of old and rare books. Undoubtedly, the most valuable part of the library of Paul Gore consisted of books on the history of Bessarabia. Documents from the National Archives of the Republic of Moldova in Chişinău confirm that he inherited a large part of books from his father Gheorghe Gore (1839-1909. A study of the Paul Gore Fund at the National Archives of Romania in Bucharest gave us a lot of documentary evidence of the destiny of this Bessarabian noble library, which later became a property of the King Ferdinand Fund. However, the fate of its most valuable part - books on the history of Bessarabia, consisted of 651 units of the total number of 6456 volumes - is still unknown.

Performing Protest in Cross-Cultural Spaces: Paul Robeson and Othello

Directory of Open Access Journals (Sweden)

Sawyer Robert

2017-09-01

Full Text Available When the famous African-American actor and singer Paul Robeson played the lead in Shakespeare’s Othello in London in 1930, tickets were in high demand during the production’s first week. The critical response, however, was less positive, although the reviews unanimously praised his bass-baritone delivery. When Robeson again played Othello on Broadway thirteen years later, critics praised not only his voice but also his acting, the drama running for 296 performances. My argument concerning Robeson uses elements first noted by Henri Lefebvre in his seminal work, The Production of Space, while I also draw on Paul Connerton’s work on commemorative practices. Using spatial and memorial theories as a backdrop for examining his two portrayals, I suggest that Robeson’s nascent geopolitical awareness following the 1930 production, combined with his already celebrated musical voice, allowed him to perform the role more dramatically in 1943.

75 FR 72964 - Determinations of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur...

Science.gov (United States)

2010-11-29

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 [R09-OAR-2010-0718; FRL-9233-1] Determinations of Attainment by the Applicable Attainment Date for the Hayden, Nogales, Paul Spur/Douglas PM10 Nonattainment... November 2, 2010 (75 FR 67220), direct final rule determining that the Hayden, Nogales, and Paul Spur...

Présentation de Paul Colonna

OpenAIRE

Corvol, Pierre

2013-01-01

Cher Collègue, Cher Paul Colonna, Il y a moins de vingt ans est apparue dans le monde une nouvelle chimie, la chimie verte. Cette chimie est une alternative à l’utilisation du carbone fossile et d’autres types d’énergie non renouvelables (gaz, charbon). La chimie traditionnelle à base de pétrole est certes performante, créative, compétitive, et répond bien à nos besoins, mais elle est aussi polluante et épuise les ressources de carbone fossile. La chimie verte se développe à côté de la chimie...

The Central Dogma of Molecular Biology

Indian Academy of Sciences (India)

Srimath

Since that tim e,m any disciplines have m im icked ... of religion, he considered dogm as sim ply as bold hy- p oth eses ... Form any students,now fam iliarw ith the C entralD ogm a since their ..... m olecules,R N A s and proteins,existed initially,and D N A .... B J Strasser, A world in one dimension: Linus Pauling, Francis Crick.

Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients.

Science.gov (United States)

Linedale, Richard; Schmidt, Campbell; King, Brigid T; Ganko, Annabelle G; Simpson, Fiona; Panizza, Benedict J; Leggatt, Graham R

2017-01-01

Perineural spread of tumour cells along cranial nerves is a severe complication of primary cutaneous squamous cell carcinomas of the head and neck region. While surgical excision of the tumour is the treatment of choice, removal of all the tumour is often complicated by the neural location and recurrence is frequent. Non-invasive immune treatments such as checkpoint inhibitor blockade may be useful in this set of tumours although little is understood about the immune response to perineural spread of squamous cell carcinomas. Immunohistochemistry studies suggest that perineural tumour contains a lymphocyte infiltrate but it is difficult to quantitate the different proportions of immune cell subsets and expression of checkpoint molecules such as PD-1, Tim-3 and CTLA-4. Using flow cytometry of excised perineural tumour tissue, we show that a T cell infiltrate is prominent in addition to less frequent B cell, NK cell and NKT cell infiltrates. CD8 T cells are more frequent than other T cells in the tumour tissue. Amongst CD8 T cells, the frequency of Tim-3, CTLA-4 and PD-1 expressing cells was significantly greater in the tumour relative to the blood, a pattern that was repeated for Tim-3, CTLA-4 and PD-1 amongst non-CD8 T cells. Using immunohistochemistry, PD-1 and PD-L1-expression could be detected in close proximity amongst perineural tumour tissue. The data suggest that perineural SCC contains a mixture of immune cells with a predominant T cell infiltrate containing CD8 T cells. Elevated frequencies of tumour-associated Tim-3+, CTLA-4+ and PD-1+ CD8 T cells suggests that a subset of patients may benefit from local antibody blockade of these checkpoint inhibitors.

Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients.

Directory of Open Access Journals (Sweden)

Richard Linedale

Full Text Available Perineural spread of tumour cells along cranial nerves is a severe complication of primary cutaneous squamous cell carcinomas of the head and neck region. While surgical excision of the tumour is the treatment of choice, removal of all the tumour is often complicated by the neural location and recurrence is frequent. Non-invasive immune treatments such as checkpoint inhibitor blockade may be useful in this set of tumours although little is understood about the immune response to perineural spread of squamous cell carcinomas. Immunohistochemistry studies suggest that perineural tumour contains a lymphocyte infiltrate but it is difficult to quantitate the different proportions of immune cell subsets and expression of checkpoint molecules such as PD-1, Tim-3 and CTLA-4. Using flow cytometry of excised perineural tumour tissue, we show that a T cell infiltrate is prominent in addition to less frequent B cell, NK cell and NKT cell infiltrates. CD8 T cells are more frequent than other T cells in the tumour tissue. Amongst CD8 T cells, the frequency of Tim-3, CTLA-4 and PD-1 expressing cells was significantly greater in the tumour relative to the blood, a pattern that was repeated for Tim-3, CTLA-4 and PD-1 amongst non-CD8 T cells. Using immunohistochemistry, PD-1 and PD-L1-expression could be detected in close proximity amongst perineural tumour tissue. The data suggest that perineural SCC contains a mixture of immune cells with a predominant T cell infiltrate containing CD8 T cells. Elevated frequencies of tumour-associated Tim-3+, CTLA-4+ and PD-1+ CD8 T cells suggests that a subset of patients may benefit from local antibody blockade of these checkpoint inhibitors.

20 old and rare books from the library of Paul Gore

Directory of Open Access Journals (Sweden)

Liviu Papuc

2014-12-01

Full Text Available As is well known, most of the large library of Paul Gore, nearly 5,000 volumes, as evidenced by preserved inventory list, is currently kept in the “M. Eminescu” Central University Library in Iaşi. Based on dozens of specimens found in the storages and on the notes made by Paul Gore in the inventory-catalog, the paper presents their bibliographic description. It is made in the continuation of a communication that is to be printed in the Magazine of the Museum of the “Al.I. Cuza” University of Iaşi and in order to complete a full catalog of the library of the great scientist, the work on which was begun with great success by other researchers in the field.

STUDI KOMPARASI SAMINISME DENGAN JEAN PAUL SARTRE TENTANG KEBEBASAN (Tinjauan Filsafat Sosial

Directory of Open Access Journals (Sweden)

Restu Trisnova

2016-09-01

Full Text Available The comparative study between Saminism concept and Jean Paul Sartre thought of freedom are: 1 Human freedom, according to Sartre, is an absolute freedom. No other rules which are able to determine human either God or other people; 2 The Saminism concept of freedom is an individual freedom. It means every individual as a subject is able to decide their own choice. Every individual as a subject is independent without any outside order; 3 Saminism freedom conveys individual responsibility. It means every person’s freedom has individual responsibility. Every doer subject can decide everything based on their interest. Therefore, the freedom and responsibility in Saminism actualizes the Jean Paul Sartre thought of freedom.

Coordinated Traffic Incident and Congestion Management (TIM-CM) : Mitigating Regional Impacts of Major Traffic Incidents in the Seattle I-5 Corridor

Science.gov (United States)

2018-02-02

Within the Seattle metropolitan area, traffic incident management (TIM) operations provide a multi-jurisdictional and coordinated strategy to detect, respond to, and clear traffic incidents so that traffic flow can be restored quickly and safely. The...

Surgical management of common bile duct stones at Saint Paul's ...

African Journals Online (AJOL)

Background: This study was aimed at evaluating the trend and outcome of surgical management of choledocholithiasis in St. Paul Teaching Hospital Addis Ababa, Ethiopia. Methods: This was a clinical based retrospective analysis. The operation register was used to identify the cases that were operated for biliary lithiasis.

A School-Based Enterprise: The Saint Pauls, North Carolina Experience.

Science.gov (United States)

Paquin, Thomas F.

1991-01-01

The superintendent of Saint Pauls Schools describes how educators, community leaders, businesspersons, and high school students worked together to develop the Way Off Broadway Deli, a successful school-based enterprise providing experiential education in entrepreneurship and small business management, as well as student employment and local…

Dr TIM: Ray-tracer TIM, with additional specialist scientific capabilities

Science.gov (United States)

Oxburgh, Stephen; Tyc, Tomáš; Courtial, Johannes

2014-03-01

We describe several extensions to TIM, a raytracing program for ray-optics research. These include relativistic raytracing; simulation of the external appearance of Eaton lenses, Luneburg lenses and generalised focusing gradient-index lens (GGRIN) lenses, which are types of perfect imaging devices; raytracing through interfaces between spaces with different optical metrics; and refraction with generalised confocal lenslet arrays, which are particularly versatile METATOYs. Catalogue identifier: AEKY_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEKY_v2_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licencing provisions: GNU General Public License No. of lines in distributed program, including test data, etc.: 106905 No. of bytes in distributed program, including test data, etc.: 6327715 Distribution format: tar.gz Programming language: Java. Computer: Any computer capable of running the Java Virtual Machine (JVM) 1.6. Operating system: Any, developed under Mac OS X Version 10.6 and 10.8.3. RAM: Typically 130 MB (interactive version running under Mac OS X Version 10.8.3) Classification: 14, 18. Catalogue identifier of previous version: AEKY_v1_0 Journal reference of previous version: Comput. Phys. Comm. 183(2012)711 External routines: JAMA [1] (source code included) Does the new version supersede the previous version?: Yes Nature of problem: Visualisation of scenes that include scene objects that create wave-optically forbidden light-ray fields. Solution method: Ray tracing. Reasons for new version: Significant extension of the capabilities (see Summary of revisions), as demanded by our research. Summary of revisions: Added capabilities include the simulation of different types of camera moving at relativistic speeds relative to the scene; visualisation of the external appearance of generalised focusing gradient-index (GGRIN) lenses, including Maxwell fisheye, Eaton and Luneburg lenses; calculation of

[Rethinking ethics with Paul Ricœur. Nursing: between responsibility, care and justice].

Science.gov (United States)

Svandra, Philippe

2016-03-01

In this article, the purpose is less praising Paul Ricoeur's work than enlightening how the reader may actually find some practical, even operative help in this philosophical thought. This is particularly true regarding the fields of medicine and care. Paul Ricœur is now worldwide renowned as a major philosophical figure of the 20th century, and with books such as "Oneself as another", he occupies a very peculiar place at the crossroads of phenomenology and hermeneutics. Through both these philosophical traditions, Paul Ricœur offers some narrative ethics which may greatly sustain caregivers in their reflexion. Yet, the aim of this article is to focus on this philosopher who invites us to inhabit and play a role in this world. The goal is also to bring out the pragmatic ethics that this thinker developed, based on Aristotelian and Kantian traditions. Then, this piece seeks to demonstrate how the three stages of Ricoeur's "petite éthique" (his "small ethics"), which are the self's aim "for the good life with and for others in just institutions" can shed some light on the ethical consideration of politicals and caregivers.

Sympathetic cooling and crystallization of ions in a linear Paul trap

International Nuclear Information System (INIS)

Drewsen, M.; Bowe, P.; Hornekaer, L.; Brodersen, C.; Schiffer, J.P.; Hangst, J.S.; Schiffer, J.P.

1999-01-01

Coulomb crystals, containing up to a few hundred ions of which more than 50% were cooled sympathetically by the Coulomb interaction with laser cooled Mg + ions, have been produced in a linear Paul trap. By controlling the balance of the radiation pressure from the two cooling lasers, the Coulomb crystals could be segregated according to ion species. Previous studies of ion crystals and molecular dynamics simulations suggest that the temperature may be around 10 mK or lower. The obtained results indicate that a wide range of atomic and molecular ions, which due to their internal structures are not amenable to direct laser cooling, can be effectively cooled and localized (crystallized) in linear Paul traps. For high resolution spectroscopy of such ions this may turn out to be very useful. copyright 1999 American Institute of Physics

Improving Success in Developmental Mathematics: An Interview with Paul Nolting

Science.gov (United States)

Boylan, Hunter R.

2011-01-01

This article presents an interview with Dr. Paul Nolting, a national expert in assessing individual math learning problems, developing effective student learning strategies, and assessing institutional variables that affect math success. Since his dissertation in 1986 on improving math success with study skills Dr. Nolting has consulted with over…

The Italian origins of FAO and Paul Otlet

OpenAIRE

Guarasci, Roberto; Taverniti, Maria

2016-01-01

Nowadays the strategic role of international organizations, which manage and provide information systems and library services in the agricultural domain, is universally recognized. This paper focuses on the origin of the Food and Agriculture Organization of the United Nations (FAO) by presenting a critical edition of the Rapport by Paul Otlet to the marquis Cappelli, pr?sident de l?Institut International d?Agricolture (Otlet, 1911) that includes original documents and outlines the first steps...

W3C director Tim Berners-Lee to be Knighted by Queen Elizabeth web inventor recognized for contributions to internet development

CERN Document Server

2003-01-01

"Tim Berners-Lee, the inventor of the World Wide Web and director of the World Wide Web Consortium (W3C), will be made a Knight Commander, Order of the British Empire (KBE) by Queen Elizabeth" (1/2 page).

EnviroAtlas - Minneapolis/St. Paul, MN - BenMAP Results by Block Group

Data.gov (United States)

U.S. Environmental Protection Agency — This EnviroAtlas dataset demonstrates the effect of changes in pollution concentration on local populations in 1,772 block groups in Minneapolis/St. Paul, Minnesota....

Características de las fallas en alimentadores de 13,8 kV del sistema soterrado de La Habana;Characteristic of 13,8 kV feeders faults of the Havana underground system

Directory of Open Access Journals (Sweden)

Boris Alba - Valle

2011-06-01

Full Text Available El sistema soterrado de La Habana enfrenta problemas de continuas fallas en sus alimentadores de 13,8 kV. En este trabajo se determinan las características de estas averías, en el período comprendido entre los años 2007 y 2009, y se proponen algunas medidas objetivas con el fin de contribuir a su disminución. La investigación se basó fundamentalmente en el estudio de la base de datos de los alimentadores de 13,8 kV proporcionada por el departamento técnico de la Unidad Empresarial Básica (UEB Soterrada y en el uso de herramientas estadísticas digitales. Como resultado se pudo constatar que las fallas son más frecuentes en los alimentadores de la subestación de Tallapiedra producto de la humedad en cables y empalmes con aislamiento de PILC (papel impregnado en aceite y con cubierta de plomo, dispuestos por tierra muerta. Finalmente, las medidas propuestas tuvieron un impacto positivo en la disminución de estas fallas, en un período inferior a un año.The Havana underground system has problems of continuous faults in their 13,8 kV feeders. In this article the characteristics of these mishaps in the period of 2007 to 2009 are determined and purpose some objective measurements with the end of contributing to their decrease. The investigation was fundamentally based on the study of the 13,8 kV feeders database proportioned by the technical department of the Underground Basic Managerial Unit (UEB and the use of digital statistical tools. As a result, it was verified that the faults occur with more frequency in the Tallapiedra substation feeders, due to the humidity in cables and connections with PILC isolation (impregnated in oil and lead covered paper, prepared for undergrounding directly in the earth. Finally, the proposed measures had a positive impact in the decrease of these faults, in a period less than to a year.

Reframing Paul's sibling language in light of Jewish epistolary forms ...

African Journals Online (AJOL)

2015-06-17

Jun 17, 2015 ... Reframing Paul's sibling language in light of Jewish epistolary forms of ... believers including Gentiles signals the re-definition of the family of Abraham. Read online: ..... Thirdly, some significant differences are detected between. Jewish ..... Rome (Moxnes 1980:78), and that 'the weak' in faith in. Romans 14 ...

Paul Trap Simulator Experiment (PTSX) to simulate intense beam propagation through a periodic focusing quadrupole field

International Nuclear Information System (INIS)

Davidson, Ronald C.; Efthimion, Philip C.; Gilson, Erik; Majeski, Richard; Qin, Hong

2002-01-01

The Paul Trap Simulator Experiment (PTSX) is under construction at the Princeton Plasma Physics Laboratory to simulate intense beam propagation through a periodic quadrupole magnetic field. In the Paul trap configuration, a long nonneutral plasma column is confined axially by dc voltages on end cylinders at z=+L and z=-L, and transverse confinement is provided by segmented cylindrical electrodes with applied oscillatory voltages ±V 0 (t) over 90 deg. segments. Because the transverse focusing force is similar in waveform to that produced by a discrete set of periodic quadrupole magnets in a frame moving with the beam, the Paul trap configuration offers the possibility of simulating intense beam propagation in a compact laboratory facility. The experimental layout is described, together with the planned experiments to study beam mismatch, envelope instabilities, halo particle production, and collective wave excitations

Paul Trap Simulator Experiment (PTSX) to simulate intense beam propagation through a periodic focusing quadrupole field

Science.gov (United States)

Davidson, Ronald C.; Efthimion, Philip C.; Gilson, Erik; Majeski, Richard; Qin, Hong

2002-01-01

The Paul Trap Simulator Experiment (PTSX) is under construction at the Princeton Plasma Physics Laboratory to simulate intense beam propagation through a periodic quadrupole magnetic field. In the Paul trap configuration, a long nonneutral plasma column is confined axially by dc voltages on end cylinders at z=+L and z=-L, and transverse confinement is provided by segmented cylindrical electrodes with applied oscillatory voltages ±V0(t) over 90° segments. Because the transverse focusing force is similar in waveform to that produced by a discrete set of periodic quadrupole magnets in a frame moving with the beam, the Paul trap configuration offers the possibility of simulating intense beam propagation in a compact laboratory facility. The experimental layout is described, together with the planned experiments to study beam mismatch, envelope instabilities, halo particle production, and collective wave excitations.

Assimilating to Power in Two Different World-Systems: An Analysis of Paul and Herzl

Directory of Open Access Journals (Sweden)

Khaldoun Samman

2015-08-01

Full Text Available This essay concerns two Jewish men from different historical formations: the Apostle Paul, a Jew living in the Roman Empire in the first century and one of the founding figures of Christianity, and Theodor Herzl, a Jew living in late-nineteenth-century Austria and the founding father of Zionism, a Jewish nationalist movement. My central argument is that both men employed an assimilationist strategy that linked their identity to powerful social forces of their time, strategically restructuring their identity so that they could move into the most powerful centers of their social system—Paul navigating himself towards Rome and Herzl setting his gaze west even while physically moving east. My objective here is to demonstrate how these two Jewish figures used Christianity and Zionism, respectively, to assimilate towards those who hold real power, each of them appropriating the ideology of his movement in order to join the most powerful sector of his “world.” Yet I also intend to demonstrate that, while they both shared a desire to assimilate to power, the strategies they implemented to reach their goals were radically different: Paul using a universalistic discourse, what I shall call “Israel in the spirit,” whereas Herzl chose the particularistic discourse of “Israel in the flesh.” This is due, I argue, to the fact that both of these great historical figures were reacting to the social and political forces of their times, Paul to the centripetal forces of ancient world-empires and Herzl to the centrifugal forces of the modern world-system.

High-Resolution Zircon U-Pb CA-TIMS Dating of the Carboniferous—Permian Successions, Paraná Basin, Brazil

Science.gov (United States)

Griffis, N. P.; Mundil, R.; Montanez, I. P.; Isbell, J.; Fedorchuk, N.; Lopes, R.; Vesely, F.; Iannuzzi, R.

2015-12-01

The late Paleozoic Ice Age (LPIA) is Earth's only record of a CO2-forced climatic transition from an icehouse to greenhouse state in a vegetated world. Despite a refined framework of Gondwanan ice distribution, questions remain about the timing, volume, and synchronicity of high-latitude continental ice and the subsequent deglaciation. These questions ultimately preclude our understanding of linkages between ice volume, sea level, and high- and low-latitude climate. Poor constraints on the timing and synchronicity of glacial and interglacial transitions reflect a lack of high-resolution radioisotopic dates from high-latitude, ice-proximal Carboniferous-Permian successions. The Rio Bonito Fm in Rio Grande do Sul State of southern Brazil hosts the oldest non-glaciogenic Carboniferous- Permian deposits of the Paraná Basin, thus recording the icehouse-to-greenhouse transition. Despite a widespread effort over the last two decades to constrain these deposits in time by means of U-Pb zircon geochronology, published data sets of the Candiota and Faxinal coals of the Rio Bonito Fm host discrepancies that may reflect post- eruptive open system behavior of zircon and analytical artifacts. These discrepancies have hindered the correlation of the Candiota and Faxinal sediments within the larger Gondwanan framework. Here we present the first U-Pb ages on closed system single zircons using CA-TIMS techniques on Permo-Carboniferous ash deposits of the Paraná Basin. Preliminary results indicate two major and distinct coal-forming periods that are separated by ca 10 Ma. Our results and conclusions are not in agreement with multi- crystal U-Pb TIMS and SIMS ages that suggest coeval deposition of the Candiota and Faxinal coals. CA-TIMS analyses applied to zircons from additional ash deposits are aimed at constructing a robust chronostratigraphic framework for the Carboniferous- Permian succession of the Paraná Basin, which will facilitate a better understanding of the timing and

O pensamento criativo de Paul Klee: arte e música na constituição da Teoria da Forma The creative thinking of Paul Klee: art and music in the formation of the Theory of Form

Directory of Open Access Journals (Sweden)

Rosana Costa Ramalho de Castro

2010-01-01

Full Text Available Estudo sobre a Teoria da Forma concebida no início do século XX pelo artista plástico Paul Klee e publicado no livro O Pensamento Criativo (KLEE, 1920. A Teoria da Forma de Paul Klee é uma demonstração do pensamento artístico que adota pressupostos formais, previamente estabelecidos para resultar na prática da representação artística. Klee identificou as relações formais entre a música e as artes visuais, apresentando conexões entre a linha melódica e a linha no desenho; o ritmo e as seqüências de módulos e sub-módulos; os tempos dos compassos e as divisões da pintura; a métrica da música e a modulação da forma e da cor nas artes visuais. Klee também apresentou suas experiências com superposição de cores e texturas para representar visualmente a polifonia. A Teoria da Forma de Paul Klee é um exemplo de estudo que pressupõe modelos formais para a elaboração artística e projetual.Study on the Theory of Form conceived in the early twentieth century by artist Paul Klee and published in the book The Creative Thinking (KLEE, 1920. The Theory of Form of Paul Klee is a demonstration of an artistic thought that adopts the previously established formal prerequisites that result in the practice of artistic representation. Klee identified the formal relationship between music and the visual arts, providing connections between the melodic line and the line in the drawing, rhythm and sequence of modules and sub-modules, the pulses of the measures and the divisions of the painting, metrics in music and the modulation of shape and color in the visual arts. Klee also presented his experiences with overlapping colors and textures to visually represent polyphony. The Theory of Form of Paul Klee is an example of a study that requires formal models for the artistic and design elaboration.

Paul B. Pedersen (1936-2017).

Science.gov (United States)

Lonner, Walter J; Draguns, Juris G

2018-01-01

Presents an obituary for Paul B. Pedersen, who passed away on January 11, 2017, in a Minnetonka, Minnesota hospital. In 1973 Pedersen convened a pathfinding APA (Division 9) symposium in Montreal that resulted in the publication in 1976 of Counseling Across Cultures (Pedersen, Lonner, and Draguns, Eds.). The first book of its kind, it became the "Granddaddy" of all subsequent books in that area. The seventh edition, published in 2016 (with Trimble and Scharron-del Rio, co-eds), benefitted from his steadfast encouragement, but his deteriorating health prevented a more active role. His epitaph may well be one of his wisest and oft-quoted sayings: "All interviewing and counseling is multicultural. Each client comes to the session embodying multiple voices from the past." (PsycINFO Database Record (c) 2018 APA, all rights reserved).

TIMS analysis of Sr and Nd isotopes in melt inclusions from Italian potassium-rich lavas using prototype 1013Ω amplifiers

NARCIS (Netherlands)

Koornneef, Janne M.; Nikogosian, Igor; van Bergen, Manfred J.; Smeets, Richard; Bouman, Claudia; Davies, Gareth R.

2015-01-01

Sr and Nd isotopes were determined using new thermal ionisation mass spectrometry (TIMS) techniques for a suite of 21 olivine-hosted (85-92mol% Fo) melt inclusions selected from potassic and ultra-potassic lavas from the Italian peninsula. Sr isotopes were measured using default 1011Ω resistors,

Use of 1012 ohm current amplifiers in Sr and Nd isotope analyses by TIMS for application to sub-nanogram samples

NARCIS (Netherlands)

Koornneef, J.M.; Bouman, C.; Schwieters, J.B.; Davies, G.R.

2013-01-01

We have investigated the use of current amplifiers equipped with 10 12 ohm feedback resistors in thermal ionisation mass spectrometry (TIMS) analyses of sub-nanogram sample aliquots for Nd and Sr isotope ratios. The results of analyses using the 1012 ohm resistors were compared to those obtained

Recovering Philosophy as the Love of Wisdom: A Contribution of St. John Paul II

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Pawel Tarasiewicz

2016-03-01

Full Text Available The article aims at demonstrating that, by his teaching on human person and his action, St. John Paul II (also known as Karol Wojtyła implicitly contributed to a resolution of the most serious problem of contemporary philosophy, which consists in separating wisdom from love and substituting wisdom with understanding or knowledge. The author concludes that John Paul II makes a persuasive contribution to recover philosophy as the love of wisdom by (1 identifying truth in the area of freedom, self-fulfillment and conscience, and (2 appealing to man’s honesty and happiness.

Flebotomíneos de Timóteo, Estado de Minas Gerais, Brasil (Diptera: Psychodidae Sand flies in Timóteo, Minas Gerais, Brazil (Diptera: Psychodidae

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José Dilermando Andrade Filho

1997-10-01

Full Text Available Casos esporádicos de leishmaniose tegumentar têm ocorrido no Município de Timóteo, Minas Gerais, basicamente na população rural. Para conhecer a fauna de flebotomíneos da região, foram instaladas sete armadilhas luminosas de New Jersey na cidade, em sete diferentes bairros. As coletas foram realizadas no período de junho a outubro de 1994, dezembro de 1994 e janeiro a março de 1995, com um total de 3.240 horas por armadilha. Foram capturados 4.396 flebotomíneos, distribuídos em dois gêneros e vinte espécies: Brumptomyia cunhai, Brumptomyia nitzulescui, Lutzomyia (Nyssomyia whitmani, Lutzomyia (Nyssomyia intermedia, Lutzomyia quinquefer, Lutzomyia lenti, Lutzomyia (Pintomyia fischeri, Lutzomyia migonei, Lutzomyia sallesi, Lutzomyia termitophila, Lutzomyia aragaoi, Lutzomyia borgmeieri, Lutzomyia (Psathyromyia lutziana, Lutzomyia (Sciopemyia sordellii, Lutzomyia (Pintomyia pessoai, Lutzomyia (Trichopygomyia longispina, Lutzomyia misionensis, Lutzomyia (Psychodopygus davisi, Lutzomyia lanei, Lutzomyia (Pressatia sp. A espécie L. (N. whitmani foi a mais freqüente com 52,12%, seguida de L. (N. intermedia com 34,10%, e ambas podem estar participando da transmissão de leishmaniose cutânea na região.Sporadic cases of tegumentary leishmaniasis have occurred in Timóteo, Minas Gerais State, basically among the rural population. In order to study the region's sand fly population, New Jersey light traps were set in seven different neighborhoods. Specimens were gathered from June through October 1994, December 1994, and January through March 1995, with a total of 3,240 hours per trap. A total of 4,396 sand flies were captured, distributed among two genera and twenty species: Brumptomyia cunhai, Brumptomyia nitzulescui, Lutzomyia (Nyssomyia whitmani, Lutzomyia (Nyssomyia intermedia, Lutzomyia quinquefer, Lutzomyia lenti, Lutzomyia (Pintomyia fischeri, Lutzomyia migonei, Lutzomyia sallesi, Lutzomyia termitophila, Lutzomyia aragaoi, Lutzomyia

REvISITING PAul'S PARAdIGMATIC, SElf-CRITICAl REMARkS IN 1 ...

African Journals Online (AJOL)

However, in 1 Corinthians 15:8-10 Paul openly admits about being in error in the past ..... Much has been written about the expression e[ktrwma in verse 8. This .... Collins 2008:120- .... The Gospel of John in cultural and rhetorical perspective.

the lukan periplus of paul's third journey with a textual conundrum

African Journals Online (AJOL)

convenience of the few fee-paying passengers. to Jerusalem. Paul does ... starts to warn him of the danger ahead in Jerusalem, which probably occurred in Troas ... conduct business along the way at their nightly ports of call. 2.2 The genre of ...

Narrative Refiguration of Social Events: Paul Ricoeur's Contribution to Rethinking the Social

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Anna Borisenkova

2010-12-01

Full Text Available The analysis of events has been a central issue for social sciences for a long time. The problem of an event's definition and distinction is still at stake in sociological debates. The purpose of this paper is to demonstrate the contribution of Paul Ricoeur's narrative theory to social events studies. First, this is done through the explication of the concept in the framework of narrative approach. Secondly, the paper highlights the narrative's capacity of 'refiguring' the social by re-describing social events, subordinating their succession to the logic of story-telling and transforming temporal characteristics as well. Apart from some insights, interpretative explanations and illustrations the paper provides critical arguments concerning the limitations of Paul Ricoeur's narrative approach with respect to sociological event-analysis.     L'analyse des événements a toujours été une question centrale pour l'histoire et les sciences sociales. Le problème de la définition et de la distinction des événements est encore en jeu dans les débats sociologiques contemporains. L'objectif de cet article est de s'attarder sur la contribution de la théorie de Paul Ricœur aux études des événements sociaux.  Après avoir montré les limites d'une conception impersonnelle de l'événement, l'auteur se penche sur la solution narrative proposée par Ricœur, à savoir la capacité du récit à “refigurer” du Social par la re-description des événements sociaux. Il s'agit de soumettre la logique de la succession temporelle à la logique de la narration. Tout en rendant justice à la valeur heuristique de telles analyses (à travers une série d'explicitations et d'illustrations, l'article pointe les limites de l'approche narrative de Paul Ricœur au regard des analyses sociologique des événements.  

Measurements of β - ν angular correlations using a transparent Paul trap

International Nuclear Information System (INIS)

Ban, G.; Delahaye, P.; Le Brun, Ch.; Lienard, E.; Mauger, F.; Naviliat-Cuncic, O.; Szerypo, J.; Tamain, B.

1999-06-01

The potentiality to search for physics beyond the Standard Model by means of precision measurements of β - ν angular correlations in nuclear β-decay is discussed. The possibility to reveal unexpected time reversal invariant tensor type contributions is investigated and the pure Gamow-Teller decay of 6 He is considered as a possible candidate. A new experimental method is proposed which is based on the use of a transparent Paul trap surrounded by detectors to directly record β-ion coincidences in an event-by-event mode. The experiment requires intense beams of radioactive nuclei like those which will become available at the Low Energy Facility near SPIRAL at GANIL. Such beams should preferably be efficiently cooled and bunched prior to their injection into the Paul trap. Estimates of the transmission figure required for the cooling and bunching system and of the measuring time to achieve a first step are presented. (author)

Amenaza sismica por método determinista en el triángulo de fallas Valera-Boconó-Oca en el occidente de Venezuela

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Castilla Raymi A.

2002-08-01

="font-family: ">EI desarrollo de múltiples proyectos de geología de fallas activas en Venezuela ha permitido que el país cuente hoy día con una base de datos completa y de gran calidad, usada como complemento a la información instrumental en los cálculos de amenaza sísmica del país con métodos probabilistas. En el presente trabajo se utiliza esta información geológica disponible para realizar cálculos de amenaza con métodos deterministas para luego comparar los resultados y proponer la implantación de metodologías mixtas que permitan aprovechar mejor los datos, tanto en la ventana instrumental como en la geológica. Sobre la base de disponibilidad de información publicada y de complejidad en la geometría de las mayores estructuras, se ha escogido una zona del occidente del país limitada por las fallas de Valera, Bocono y Oca.

Se utilizan sismos máximos creibles de cada falla, distancias mínimas a la superficie de ruptura y las leyes de atenuación necesarios para crear un marco multiescenario combinando todas las estructuras que puedan, potencialmente, generar amenaza.

La zona de estudio, con un área aproximada de 45.000 km2 que incluye tres capitales de estado y una actividad industrial importante, es cubierta con una red espaciada cada 5 kilómetros para el cálculo de los valores de aceleración.

Los resultados se muestran en mapas con areas de isoaceleraciones donde se puede observar un control marcado de la geometría de las fallas activas sobre los valores de aceleración esperados, por encima de la sismicidad asociada a cada una de ellas.

New sequential separation procedure for Sr, Nd and Pb isotope ratio measurement in geological material using MC-ICP-MS and TIMS

Digital Repository Service at National Institute of Oceanography (India)

Makishima, A.; Nath, B.N.; Nakamura, E.

A new 3-step sequential separation chemistry for Sr, Nd and Pb from silicate samples, which is suitable for isotope analysis by MC-ICP-MS as well as TIMS, has been developed. The chemistry is designed to minimize the number of evaporation steps...

New perspectives on approximation and sampling theory Festschrift in honor of Paul Butzer's 85th birthday

CERN Document Server

Schmeisser, Gerhard

2014-01-01

Paul Butzer, who is considered the academic father and grandfather of many prominent mathematicians, has established one of the best schools in approximation and sampling theory in the world. He is one of the leading figures in approximation, sampling theory, and harmonic analysis. Although on April 15, 2013, Paul Butzer turned 85 years old, remarkably, he is still an active research mathematician. In celebration of Paul Butzer’s 85th birthday, New Perspectives on Approximation and Sampling Theory is a collection of invited chapters on approximation, sampling, and harmonic analysis written by students, friends, colleagues, and prominent active mathematicians. Topics covered include approximation methods using wavelets, multi-scale analysis, frames, and special functions. New Perspectives on Approximation and Sampling Theory requires basic knowledge of mathematical analysis, but efforts were made to keep the exposition clear and the chapters self-contained. This volume will appeal to researchers and graduate...

Passings to note: Paul Michael Packman, MD; S. Charles Schulz, MD.

Science.gov (United States)

Black, Donald W

2018-02-01

One of the keys to the success of Annals of Clinical Psychiatry has always been the tireless efforts of our dedicated Editorial Board. We recently lost 2 longtime Editorial Board members, Drs. Paul Michael Packman and S. Charles Schulz. Both will be greatly missed.

Paul Valery: Un canto de frontera

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Eduardo Carranza

1966-09-01

Full Text Available Paul Valery nació en Cette el 30 de octubre de 1871, de padre francés y de madre italiana. Hizo sus primeros estudios en un colegio de su pequeña ciudad natal y realizó luego con sus padres un viaje infantil a París y a Londres. En 1884 siguió los cursos del Colegio de Montpellier. Pasaba sus vacaciones en Génova con los suyos, circunstancia que incorporó a su espíritu una estela de reminiscencias italianas. Siguió luego cursos en la Facultad de Derecho y, ya en el umbral de la primera juventud, vacilaba ante la escogencia de su destino.

DIFERENCE EFFICACY BETWEEN WINNER AND DEFEAT TIM ON WORLD CHAMPIONSHIP IN SOCCER GAME 2006

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Alen Kapidžić

2007-04-01

Full Text Available We analyse thirty games of world championship in soccer 2006 with am to determine variables which contribute signifi cant distinction and differences between winner and defeat tim. Fortifi cation differences in aplayed variables we will apply multivariant analisis of variance. For this examination we will use variable of tehnich elements, and some of tactics calculation and estimate quality of tehnics elements according to the judges. This problem is very interesting for exploration, and it’s leading to modern tendency’s so these are the elementary reasons why we chose this kind of exploration.

Calibration Laboratory of the Paul Scherrer Institute

International Nuclear Information System (INIS)

Gmuer, K.; Wernli, C.

1994-01-01

Calibration and working checks of radiation protection instruments are carried out at the Calibration Laboratory of the Paul Scherrer Institute. In view of the new radiation protection regulation, the calibration laboratory received an official federal status. The accreditation procedure in cooperation with the Federal Office of Metrology enabled a critical review of the techniques and methods applied. Specifically, personal responsibilities, time intervals for recalibration of standard instruments, maximum permissible errors of verification, traceability and accuracy of the standard instruments, form and content of the certificates were defined, and the traceability of the standards and quality assurance were reconsidered. (orig.) [de

Paul of Aegina (ca 625-690 ad), Reconstructing Male Gynecomastia.

Science.gov (United States)

Tsoucalas, Gregory; Sgantzos, Markos

2017-06-01

Paul of Aegina thrived with his innovative operations, practically creating a kind of a new surgical school. He had deeply believed in human's body perfection introducing a series of cosmetic operations. Among them stood the male's breasts reconstruction in the case of pseudo-gynecomastia. His intervention was replicated by both the western Europeans and the Arabs.

Constancy of character and Paul's understanding of change in his ...

African Journals Online (AJOL)

2010-11-21

Nov 21, 2010 ... Paul's concern for explaining his own change in behaviour as positive and ... of fear of those of the circumcision (Gl 2:11–14), is not justified. ... have been changed by a divine call, and any further change of behaviour dishonours the divine ... Jewish Christians to which Betz appeals, as well as the idea that ...

Hindemith, Paul: "Complete sonatas for Solo Instrument and Piano" / Michel Roubinet

Index Scriptorium Estoniae

Roubinet, Michel

1997-01-01

Uuest heliplaadist "Hindemith, Paul: "Complete sonatas for Solo Instrument and Piano", vol. 6. Sonate pour trompette et piano. Sonates pour orgue nos 1 a 3. Sonate pour cor et piano. Ensemble Villa Musica: Kalle Randalu (piano)" MDG "Gold" 304 0696-2, distr. Media 7 (CD:160F)

Swiss synchrotron light source at the Paul Scherrer Institute at Villigen

International Nuclear Information System (INIS)

1996-02-01

The brochure describes the Swiss project for a synchrotron light source to be built at the Paul Scherrer Institute at Villigen. According to the project the synchrotron light source shall be realized up to the year 2001 at costs of 165 Million Swiss Francs. figs., tabs

The Paul Scherrer Institute, a multidisciplinary organization opened to the world

International Nuclear Information System (INIS)

Mayer, N.

2008-01-01

At the end of the second world war, the Swiss Federal Military department created a commission for the study of nuclear energy under the presidency of Paul Scherrer. This famous Swiss physicist was particularly interested in this new domain of physics and will be few years later one of the main actor of the creation of CERN, a European organization for nuclear research. Some financial problems and a nuclear accident in 1969 have blown away the dreams of a nuclear reactor entirely made in Switzerland. The Paul Scherrer Institute was born in this context in 1988 near Zurich. Twenty years later it employs about 1300 people with an operating budget of about 175 million euros financed at 85% by the Swiss confederation. This article presents the different domains of research of the institute, its infrastructures (X-ray, neutrons and muons probes), its technology transfer actions and the cooperations with France. (J.S.)

Discurso narrativo e presente histórico em Paul Ricoeur = Narrative discourse and historical present in Paul Ricoeur

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Leal, Ivanhoé Albuquerque

2016-01-01

Full Text Available Analisamos uma das teses da teoria narrativa de Paul Ricoeur que concede ao discurso histórico a habilidade de configurar a experiência temporal humana, sempre exposta à trama de perspectivas cruzadas entre a expectativa do futuro, a recepção do passado e a vivência do presente. Face à multiplicidade do tempo, os lineamentos argumentativos ricoeurianos indicam o ato narrativo como a condição tanto de pensar a efetividade das ações humanas e sua reconstrução histórica, quanto de forjar uma unidade plural própria a uma consciência hermenêutica

Matthew, Paul and the origin and nature of the gentile mission: The ...

African Journals Online (AJOL)

p1243322

previous restriction of the mission to Israel alone and demands that the disciples .... The relationship between Matthew and Paul has never been at the forefront of. Matthean studies. For the ..... eat the children's' crumbs”. London: T & T Clark.

A field- and laboratory-based quantitative analysis of alluvium: Relating analytical results to TIMS data

Science.gov (United States)

Wenrich, Melissa L.; Hamilton, Victoria E.; Christensen, Philip R.

1995-01-01

Thermal Infrared Multispectral Scanner (TIMS) data were acquired over the McDowell Mountains northeast of Scottsdale, Arizona during August 1994. The raw data were processed to emphasize lithologic differences using a decorrelation stretch and assigning bands 5, 3, and 1 to red, green, and blue, respectively. Processed data of alluvium flanking the mountains exhibit moderate color variation. The objective of this study was to determine, using a quantitative approach, what environmental variable(s), in the absence of bedrock, is/are responsible for influencing the spectral properties of the desert alluvial surface.

The Common Sense Personalism of St. John Paul II (Karol Wojtyła

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Pawel Tarasiewicz

2014-12-01

Full Text Available The article aims at showing that the philosophical personalism of Pope John Paul II (Karol Wojtyla stems from the common sense approach to reality. First, it presents Karol Wojtyla as a framer of the Lublin Philosophical School, to which he was affiliated for 24 years before being elected Pope John Paul II; it shows Wojtyla’s role in establishing this original philosophical School by his contribution to its endorsement of Thomism, its way of doing philosophy, and its classically understood personalism. Secondly, it identifies a purpose of Wojtyla’s use of the phenomenological method in his personalism and reconstructs Wojtyla’s possible answer to the question whether there is a link between moral sense and common sense in human experience.

Mr Paul: Masculinity and Paul’s self-presentation (1 Cor 11–13

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Jeremy Punt

2016-10-01

Full Text Available Notwithstanding all the corporeal and gendered language in the Pauline letters, the apostle’s bodiliness and masculinity so far has received little attention. In the 1st-century context masculinity reigned by default and provides the contemporary context for teasing out the corporeal and gendered overtones in the Pauline letters, especially in Paul’s self-presentation. Recent and intersecting masculinity studies, body theology and queer theory provide useful tools for engaging Paul as man and his bodily-focussed, gendered approach in his letters. A focus on both Paul as embodied man and his corporeal, gendered approach enable alternative readings of his letters’ concern with corporeality and the related relationships between bodies, power and life in the communities he addressed.

Development of Laser-Induced Fluorescence Diagnostic for the Paul Trap Simulator Experiment

CERN Document Server

Chung, Moses; Efthimion, Philip; Gilson, Erik P; Majeski, Richard; Startsev, Edward

2005-01-01

The Paul Trap Simulator Experiment (PTSX) is a cylindrical Paul trap whose purpose is to simulate the nonlinear dynamics of intense charged particle beam propagation in alternating-gradient magnetic transport systems. For the in-situ measurement of the transverse ion density profile in the PTSX device, which is essential for the study of beam mismatch and halo particle production, a laser-induced fluorescence diagnostic system is being developed. Instead of cesium, which has been used in the initial phase of the PTSX experiment, barium has been selected as the preferred ion for the laser-induced fluorescence diagnostic. The installation of the barium ion source and the characterization of the tunable dye laser system are discussed. The design of the collection optics with an intensified CCD camera system is also discussed. Finally, initial test results using the laser-induced fluorescence diagnostic will be presented.

Daamid poolpöördes : Paul Raua naisportreede taustast / Tiina Abel

Index Scriptorium Estoniae

Abel, Tiina

2008-01-01

Vendade Raudade loomingust sajandivahetusel ja nende erinevatest inspiratsiooniallikatest. Ka muutustest ühiskondlikus elus ja kultuuriteadvuses - pöördumine ühiskondlikult isiklikule ja psühholoogilisele, tegelikkuse ja indiviidi teadvuse ümbermõtestamine, ratsionaalse inimese asendumine tunnete ja instiktide inimesega - see ilmneb Paul Raua psühholoogilistes hingestatud naiseportreedes

The neutron Electric Dipole Moment experiment at the Paul Scherrer Institute

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Hélaine V.

2014-06-01

Full Text Available The neutron Electric Dipole Moment (nEDM is a probe for physics beyond the Standard Model. A report on the nEDM measurement performed at the Paul Scherrer Institute (Switzerland is given. A neutron spin analyzer designed to simultaneously detect both neutron spin states is presented.

What Happened to Paul? Manifestation of Abnormal Pain Response for Individuals With Autism Spectrum Disorder.

Science.gov (United States)

Goldschmidt, Janice

2017-07-01

During the progression of a pilot nutrition intervention designed to teach cooking skills to young adults with autism spectrum disorder (ASD), one participant-Paul-fell in the parking lot. Prior to the accident, Paul had been making significant gains in the program and had communicated in a number of ways his enthusiasm. After his accident, which resulted in broken and dislocated bones in his ankle, his demeanor was dramatically altered, program gains were lost, and staff noted the appearance of many new challenging behaviors. This article analyzes Paul's behavior in reference to the pain response in autism. For some time, it was believed that many individuals with ASD did not experience pain based on anecdotal reports of how individuals responded to injury with seeming indifference. This view has given way of late to a more nuanced understanding of how atypical sensory processing and stimulus over-selectivity spill over into pain pathways and pain amplification mechanisms. The consequence is not a reduction in pain sensation, but a different expression of pain, determined by that individual's particular communicative, cognitive, or physiological challenges. From this perspective, many of the disruptive and harmful behaviors that emerged after Paul's accident can be seen as a delayed response to the incident. This article concludes by arguing that professionals across all domains of health care need to begin to see behavior as communicative for those with ASD. This is particularly true of changes in behavior, which can be significant indicators of health care problems rather than something to be dismissed as another manifestation of the condition.

Paul Collier : Balancing beams

CERN Multimedia

2009-01-01

As former head of AB Operations, Paul Collier and his group were in the ‘cockpit’ for the LHC’s maiden voyage - piloting the first beam around the ring. But now, as Head of the Beams Department, he will need his feet firmly on the ground in order to balance all the beam activities at CERN. "As Department Head, I’ll have less direct contact with the machines," Collier says with a hint of regret. "I’ll still obviously be very involved, but they won’t actually let me loose in front of the keyboard anymore!" As the new Head of the BE Department, Collier will be in charge of nearly 400 people, and will oversee all the beam activities, including the preparations for the longest period of beam operation in the history of CERN. In the new organization, the BE, TE and EN Departments have been grouped together in the Accelerator and Technology Sector. "‘Partnership’ is a key word for the three departments," says Collier. "The n...

District heating/cogeneration application studies for the Minneapolis-St Paul area. Executive summary; overall feasibility and economic viability for a district heating/new cogeneration system in Minneapolis-St. Paul

Energy Technology Data Exchange (ETDEWEB)

Margen, P.; Larsson, K.; Cronholm, L.A.; Marklund, J.E.

1979-08-01

A study was undertaken to determine the feasibility of introducing a large-scale, hot-water, district-heating system for the Minneapolis-St. Paul area. The analysis was based on modern European hot-water district-heating concepts in which cogeneration power plants supply the base-load thermal energy. Heat would be supplied from converted turbines of existing coal-fired power plants in Minneapolis and St. Paul. Toward the end of the 20-year development period, one or two new cogeneration units would be required. Thus, the district-heating system could use low-grade heat from either coal-fired or nuclear cogeneration power stations to replace the space-heating fuels currently used - natural gas and distillate oil. The following conclusions can be drawn: the concept is technically feasible, it has great value for fuel conservation, and with appropriate financing the system is economically viable.

Boundaries - US Army Corps of Engineers - St. Paul District (MVP) Civil Works

Data.gov (United States)

Army Corps of Engineers, Department of the Army, Department of Defense — The US Army Corps of Engineers - St. Paul District Civil Works boundary. Boundary is based on 1:24k watershed data and coordination with MVR to determine shared...

Resurrecting Democracies : Secularity Recast in Charles Taylor, Paul Valadier, and Joseph Ratzinger

NARCIS (Netherlands)

Ossewaarde-Lowtoo, Roshnee

In this article, the alternative conception of secularity of Charles Taylor, Paul Valadier and Joseph Ratzinger (former Benedict XVI) is explored. A secularized society, which they take as an established condition, does not necessarily exclude religion, Christianity or Christian transcendence, in

Paul Cézanne

Directory of Open Access Journals (Sweden)

Emile Bernard

2009-01-01

Full Text Available Bernard afirma (no final de seu texto ter escrito este artigo em Aix em março de 1904. Na realidade este deve ter tomado sua forma definitiva mais tarde, pois contém importantes citações tiradas das cartas de Cézanne datadas de 12 e 26 de maio. Embora seja conhecido pelos especialistas, este artigo (p. 17 a 30 no número de julho de 1904 do Occident foi algo eclipsado, nos estudos sobre Cézanne, pelos dois textos do Mercure de France que compõem os Souvenirs sur Paul Cézanne... e suas diversas reedições em forma de livro. O artigo do Occident é, em grande medida, consagrado às visões gerais de Bernard sobre a arte, mas, além da famosa compilação das opiniões de Cézanne, oferece citações aparentemente textuais do artista e algumas observações às vezes profundas sobre seus métodos de trabalho e sua evolução como pintor. Os comentários sobre Pissarro e o período de Auvers parecem exatos. Quanto à autenticidade das "opiniões", devemos ter em mente, por um lado, que Bernard se preocupa em assinalar, várias vezes, neste artigo, as ocasiões em que cita as próprias palavras de Cézanne e, por outro lado, que as "opiniões" propriamente ditas são enriquecidas com trechos de cartas, o que permite supor que a seção inteira seria composta de citações autênticas. P. M. DoranBernard claims (in the end of his text to have written this article in Aix in March 1904. Actually, it must have taken its final version later, since it contains important quotes drawn from Cézanne's letters of May 12 and 26. This article (pages 17 to 30 of the issue of July 1904 of Occident, although known among scholars, was somehow eclipsed, in the studies about Cézanne, by the two texts from Mercure de France which constitute the Souvenirs sur Paul Cézanne... and its various re-editions as a book. The article in Occident is mostly dedicated to Bernard's general views on art, but it offers, beyond the famous compilation of Cézanne's opinions

Dokumentaalselt tõestatud: Paul Keresel suleti tee maailmameistri tiitlile / Paavo Kivine

Index Scriptorium Estoniae

Kivine, Paavo, 1939-

2015-01-01

Miks neli aastakümmet tipus püsinud suurmeister ei tulnud maailmameistriks. Lisatud dokument on pöördumine Venemaa Kommunistliku Partei II sekretäri ülesandeid täitnud Andrei Ždanovi poole ettepanekuga lubada Paul Keresel osaleda 1947. aasta maailmameistrivõistlustel (foto venekeelsest dokumendist ja tõlge)

Stability of Coulomb crystals in a linear Paul trap with storage-ring-like confinement

DEFF Research Database (Denmark)

Kjærgaard, Niels; Mølhave, Kristian; Drewsen, Michael

2002-01-01

We report experiments on the stability of ion Coulomb crystals in a linear Paul trap with storage-ring-like confinement. The transverse dynamics of charged particles in a trap of this type is analogous to that of a fast beam traveling through a channel with periodic, magnetic alternating gradient...... confinement. The experimentally observed stability conditions for stationary crystals comply remarkably well with current theory of crystalline plasmas and beams.......We report experiments on the stability of ion Coulomb crystals in a linear Paul trap with storage-ring-like confinement. The transverse dynamics of charged particles in a trap of this type is analogous to that of a fast beam traveling through a channel with periodic, magnetic alternating gradient...

Comparison of Nitrogen Bioaccessibility from Salmon and Whey Protein Hydrolysates using a Human Gastrointestinal Model (TIM-1

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Bomi Framroze

2014-05-01

Full Text Available Background: The TIM-1 system is a computer-controlled multi-compartmental dynamic model that closely simulates in vivo gastrointestinal tract digestion in humans. During digestion, the compounds released from meal matrix by gastric and intestinal secretions (enzymes are progressively absorbed through semipermeable membranes depending on their molecular weight. These absorbed (dialysed compounds are considered as bioaccessible, which means that they can be theoretically absorbed by the small intestine in the body. Methods: Salmon protein hydrolysate (SPH, whey protein hydrolysates extensively (WPHHigh or weakly (WPH-Low hydrolysed, non-hydrolysed whey protein isolate (WPI and mixtures of WPI:SPH (90:10, 80:20 were digested in TIM-1 using the conditions for a fast gastrointestinal transit that simulate the digestion of a liquid meal in human adults. During digestion (2 hours, samples were collected in intestinal compartments (duodenum, jejunum, and ileum and in both jejunal and ileal dialysates to determine their nitrogen content. All the products were compared in terms of kinetics of nitrogen absorption through the semipermeable membranes (bioaccessible nitrogen and nitrogen distribution throughout the intestinal compartments at the end of the 2 hour digestion. Results: After a 2 h-digestion in TIM-1, SPH was the protein substrate from which the highest amount of nitrogen (67.0% becomes available for the small intestine absorption. WPH-High had the second highest amount (56.0% of bioaccessible nitrogen while this amount decreased to 38.5–42.2% for the other protein substrates. The high nitrogen bioaccessibility of SPH is consistent with its richness in low molecular weight peptides (50% < 1000 Da. Conclusions: The results of this study indicate that SPH provides a higher proportion of bioaccessible nitrogen to a healthy adult compared to all forms of whey proteins, including extensively hydrolysed whey protein hydrolysate. The substitution of

Der andere Kisch: der Literaturhistoriker und –kritiker Paul Kisch (1883–1944)

Czech Academy of Sciences Publication Activity Database

Petrbok, Václav

2015-01-01

Roč. 23, 1-2 (2015), s. 79-100 ISSN 1803-456X Institutional support: RVO:68378068 Keywords : Kisch, Paul * literary criticism * Czech-German relationships * intercultural studies Subject RIV: AJ - Letters, Mass-media, Audiovision

Peter Paul Rubens, Galileo Galilei und die Schlacht am Weißen Berg

Czech Academy of Sciences Publication Activity Database

Konečný, Lubomír

2005-01-01

Roč. 26, č. 52 (2005), s. 85-91 ISSN 0391-9064 Institutional research plan: CEZ:AV0Z80330511 Keywords : Peter Paul Rubens * Galileo Galilei * moon Subject RIV: AL - Art, Architecture, Cultural Heritage

Development of flood-inundation maps for the Mississippi River in Saint Paul, Minnesota

Science.gov (United States)

Czuba, Christiana R.; Fallon, James D.; Lewis, Corby R.; Cooper, Diane F.

2014-01-01

Digital flood-inundation maps for a 6.3-mile reach of the Mississippi River in Saint Paul, Minnesota, were developed through a multi-agency effort by the U.S. Geological Survey in cooperation with the U.S. Army Corps of Engineers and in collaboration with the National Weather Service. The inundation maps, which can be accessed through the U.S. Geological Survey Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/ and the National Weather Service Advanced Hydrologic Prediction Service site at http://water.weather.gov/ahps/inundation.php, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the U.S. Geological Survey streamgage at the Mississippi River at Saint Paul (05331000). The National Weather Service forecasted peak-stage information at the streamgage may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the Mississippi River by means of a one-dimensional step-backwater model. The hydraulic model was calibrated using the most recent stage-discharge relation at the Robert Street location (rating curve number 38.0) of the Mississippi River at Saint Paul (streamgage 05331000), as well as an approximate water-surface elevation-discharge relation at the Mississippi River at South Saint Paul (U.S. Army Corps of Engineers streamgage SSPM5). The model also was verified against observed high-water marks from the recent 2011 flood event and the water-surface profile from existing flood insurance studies. The hydraulic model was then used to determine 25 water-surface profiles for flood stages at 1-foot intervals ranging from approximately bankfull stage to greater than the highest recorded stage at streamgage 05331000. The simulated water-surface profiles were then combined with a geographic information system digital elevation model, derived from high-resolution topography

The LPCTrap facility: A novel transparent Paul trap for high-precision experiments

International Nuclear Information System (INIS)

Rodriguez, D.; Mery, A.; Ban, G.; Bregeault, J.; Darius, G.; Durand, D.; Flechard, X.; Herbane, M.; Labalme, M.; Lienard, E.; Mauger, F.; Merrer, Y.; Naviliat-Cuncic, O.; Thomas, J.C.; Vandamme, C.

2006-01-01

A trap system has been built to perform high-precision β-decay experiments. The system is coupled to the low-energy beam line of the SPIRAL source at GANIL. The continuous ion beam from SPIRAL with energies between 10 and 20keV is slowed down by means of a buffer-gas-filled RFQ trap and ejected thereafter as short ion bunches into a novel transparent Paul trap. Two pulsed cavities located downstream from the RFQ reduce the energy of the ion bunch down to about a hundred eV for an efficient capture in the Paul trap. We describe here the complete system along with the first results obtained with stable He+4, Cl+35 and Ar+36,40 ions from the SPIRAL ECR source. An overall efficiency of 8.7(8)x10 -4 is achieved for 4 He + ions under specific conditions

Determination of isotopic composition of boron in boron carbide by TIMS and PIGE: an inter-comparison study

International Nuclear Information System (INIS)

Sasibhushan, K.; Rao, R.M.; Parab, A.R.; Alamelu, D.; Aggarwal, S.K.; Acharya, R.; Chhillar, S.; Pujari, P.K.

2015-01-01

The paper reports a comparison of results on the determination of isotopic composition of boron in boron carbide (B 4 C) samples by Thermal Ionisation Mass Spectrometry (TIMS) and Particle Induced Gamma ray Spectrometry (PIGE). B 4 C samples having varying boron isotopic composition (natural, enriched with respect to 10 B) and their synthetic mixtures) have been analysed by both the techniques. The 10 B atom% was found to be in the range of 20-67%. (author)

The history and epidemiology of Cape St Paul wilt disease of ...

African Journals Online (AJOL)

The history of the spread of the Cape St. Paul Wilt (lethal yellowing) disease of coconut in Ghana is presented. Epidemiological studies showed that the disease starts slowly, then progresses (accelerate) rapidly before levelling off. In a farm, the disease first appears randomly on single trees, foci then develop around these ...

O avesso do visível: poética de Paul Klee

Directory of Open Access Journals (Sweden)

Maria Beatriz da Rocha Lagôa

2006-01-01

Full Text Available O artista Paul Klee investiga os processos da forma, conjugando materiais e técnicas que tecem suas próprias relações. O que caracteriza sua obra é a compreensão da Modernidade, as correspondências com outras culturas e demais gêneros de expressão artística. O traço, não mediado pela referência à natureza, atua como instrumento de busca de uma forma mais livre, que se desdobra no tempo e no espaço, e exige a participação do espectador.El artista Paul Klee investiga los procesos de la forma, conjugando materiales y técnicas que tejem sus relaciones próprias. Lo que caracteriza su obra es la compreensión de la Modernidad, las correspondencias con otras culturas y otros géneros de expresión artística. El trazo, sin mediación por la referencia a la naturaleza, actua como instrumento de busca de una forma mas libre, que se desdobla en el tiempo y en el espacio, exigiendo la participación del espectador.Paul Klee investigates the process of form, conjugating materials and techniques that weave their own relations. The artist understands the Modernity, its correspondences with the other cultures and means of artistic expression. The line, non mediated by references to nature, acts as an instrument in the search for a freer form, unfolding through space and time, and demanding the participation of the viewer.

Paule Marshall and the search for the African diaspora

Directory of Open Access Journals (Sweden)

Simon Gikandi

1999-01-01

Full Text Available [First paragraph] The Fiction of Paule Marshall: Reconstructions of History, Culture, and Gender. DOROTHY HAMER DENNISTON. Knoxville: University of Tennesee Press, 1995. xxii + 187 pp. (Paper US$ 15.00 Toward Wholeness in Paule Marshall's Fiction. JOYCE PETTIS. Charlottesville: University of Virginia Press, 1995. xi + 173 pp. (Cloth US$ 29.50 Black and Female: Essays on Writings by Black Women in the Diaspora. BRITA LINDBERG-SEYERSTED. Oslo: Scandinavian University Press, 1994. 164 pp. (Paper n.p. Literary history has not been very kind to Paule Marshall. Even in the early 1980s when literature produced by African-American women was gaining prominence among general readers and drawing the attention of critics, Marshall was still considered to be an enigmatic literary figure, somehow important in the canon but not one of its trend setters. As Mary Helen Washington observed in an influential afterword to Brown Girl, Brownstones, although Marshall had been publishing novels and short stories since the early 1950s, and was indeed the key link between African-American writers of the 1940s and those of the 1960s, she was just being "discovered" in the 1980s. While there has always been a small group of scholars, most notably Kamau Brathwaite, who have called attention to the indispensable role Marshall has played in the shaping of the literary canon of the African Diaspora, and of her profound understanding of the issues that have affected the complex formation and survival of African-derived cultures in the New World, many critics have found it difficult to locate her within the American, African-American, and Caribbean traditions that are the sources of her imagination and the subject of her major works. Marshall has embraced all these cultures in more profound ways than her more famous contemporaries have, but she has not gotten the accolades that have gone to lesser writers like Alice Walker. It is indeed one of the greatest injustices of

Paul Ion Trap as a Diagnostic for Plasma Focus

Science.gov (United States)

Sadat Kiai, S. M.; Adlparvar, S.; Zirak, A.; Alhooie, Samira; Elahi, M.; Sheibani, S.; Safarien, A.; Farhangi, S.; Dabirzadeh, A. A.; Khalaj, M. M.; Mahlooji, M. S.; KaKaei, S.; Talaei, A.; Kashani, A.; Tajik Ahmadi, H.; Zahedi, F.

2010-02-01

The plasma discharge contamination by high and low Z Impurities affect the rate of nuclear fusion reaction products, specially when light particles have to be confined. These impurities should be analyzed and can be fairly controlled. This paper reports on the development of a Paul ion trap with ion sources by impact electron ionization as a diagnostic for the 10 kJ Iranian sunshine plasma focus device. Preliminary results of the residual gas are analyzed and presented.

A cross-cultural comparison of eating behaviors and home food environmental factors in adolescents from São Paulo (Brazil) and Saint Paul-Minneapolis (US).

Science.gov (United States)

Estima, Camilla C P; Bruening, Meg; Hannan, Peter J; Alvarenga, Marle S; Leal, Greisse V S; Philippi, Sonia T; Neumark-Sztainer, Dianne

2014-01-01

Describe cross-cultural differences in nutrition-related factors among adolescents from São Paulo, Brazil and St Paul-Minneapolis, US. Two large-population-based studies with cross-cultural comparisons. Twelve São Paulo and 10 St Paul-Minneapolis high schools in 2009-2010. A total of 1,148 adolescents from São Paulo and 1,632 adolescents from St Paul-Minneapolis. Meal consumption, family meals, fast-food consumption, and home food availability. Binomial regressions, weighted for age distributions and adjusted for gender, were used to compare identical measures from each sample. Generally, São Paulo adolescents reported healthier nutritional outcomes than St Paul-Minneapolis adolescents. São Paulo adolescents were 7 times less likely to report high fast-food consumption than St Paul-Minneapolis adolescents (P culture. Interventions are needed to encourage youth and their families to maintain these patterns. Copyright © 2014 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

Fallas de mercado y márgenes de comercialización en bovinos destinados al abasto de carne en la región del Papaloapan, Veracruz

Directory of Open Access Journals (Sweden)

Julio Vilaboa-Arroniz

2010-01-01

Full Text Available El objetivo de este trabajo es identificar fallas de mercado y los patrones que estipulan los precios de compra-venta, con la finalidad de determinar su influencia en el margen bruto de omercialización (mbc en el esquema de comercio tradicional de bovinos para el abasto de carne en la región del Papaloapan. Los precios se determinan de manera empírica y subjetiva, pues la habilidad para negociar y fijar el precio por parte de los agentes es determinante. Además, por cada kilo de carne que paga el consumidor, los intermediarios se quedan con el mayor mbc.

Sensor 17 Thermal Isolation Mounting Structure (TIMS) Design Improvements

Energy Technology Data Exchange (ETDEWEB)

Enstrom, K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2015-09-04

The SENSOR 17 thermographic camera weighs approximately 0.5lbs, has a fundamental mode of 167 Hz, and experiences 0.75W of heat leakage in through the TIMS. The configuration, shown in Figure 1, is comprised of four 300 Series SST washers paired in tandem with P.E.I (Ultem 100) washers. The SENSOR 17 sensor is mounted to a 300 series stainless plate with A-shaped arms. The Plate can be assumed to be at ambient temperatures (≈293K) and the I.R. Mount needs to be cooled to 45K. It is attached to the tip of a cryocooler by a ‘cold strap’ and is assumed to be at the temperature of the cold-strap (≈45K). During flights SENSOR 17 experiences excitations at frequencies centered around 10-30Hz, 60Hz, and 120Hz from the aircraft flight environment. The temporal progression described below depicts the 1st Modal shape at the systems resonant frequency. This simulation indicates Modal articulation will cause a pitch rate of the camera with respect to the body axis of the airplane. This articulation shows up as flutter in the camera.

On social justice: Comparing Paul with Plato, Aristotle and the Stoics ...

African Journals Online (AJOL)

Although Crossan elsewhere demonstrates the deep roots of this concern in the Jewish tradition, he tends to downplay the importance of Greek contributions in this regard. The purpose of this essay will be to offer, in constant dialogue with. Crossan (and Reed), a more refined comparison of social justice in Paul on the one ...

Research at the Paul Scherrer Institut

International Nuclear Information System (INIS)

Walter, H.K.

1996-01-01

The Paul Scherrer Institut (PSI) is a multidisciplinary research institute for natural sciences and technology. In national and international collaboration with universities, other research institutes and industry, PSI is active in elementary particle physics, life sciences, solid-state physics, material sciences, nuclear and non-nuclear energy research, and energy-related ecology. PSI's priorities lie in research fields which are relevant to sustainable development, serve educational needs and are beyond the possibilities of a single university department. PSI develops and operates complex research installations open of the world's most powerful cyclotron, allowing to operate high intensity secondary pion and muon beams, a neutron spallation source and various applications in medicine and materials research. A short review on research at PSI is presented, with special concentration on particle physics experiments. (author)

Literature in focus: Paul Ginsparg

CERN Multimedia

2008-01-01

Paul Ginsparg, professor of physics, computing and information science at Cornell University, is best known as the creator of an online system for distributing scientific research results. Known by scientists around the world as "arXiv.org", the system was designed to distribute electronic copies of the preprints that until 17 years ago were all distributed on paper and shipped in their thousands by the postal services. Ginsparg, at the time based at Los Alamos, carried out this work in his spare time using surplus equipment! It is amusing to look backwards and observe how this new technology was perceived in the beginning: In early 1994 Ginsparg happened to serve on a committee advising the American Physical Society (APS) about putting Physical Review Letters online. He suggested that a Web interface along the lines of the xxx.lanl.gov prototype might be a good way for the APS to disseminate its documents. A response came back from another committee member: "Installing and learni...

Elagu eesti energia : Jaan ja Jüri Ojaver, Paul Rodgers / Reet Varblane

Index Scriptorium Estoniae

Varblane, Reet, 1952-

2001-01-01

Paul Rodgersi, Jüri ja Jaan Ojaveri ühisnäitusest "Koostöö" Rakvere Kesklinna galeriis. P. Rodgersilt ja Jüri Ojaverilt on väljas Viinist "Eesti energia" näituselt naasnud tööd, Jaan Ojaverilt minimalistlikud tööriistad-objektid

Henryk Grossmann 2.0: A Critique of Paul Mason’s Book “PostCapitalism: A Guide to Our Future”

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Christian Fuchs

2016-04-01

Full Text Available This article reviews Paul Mason’s book “PostCapitalism: A Guide to Our Future”. It discusses Mason’s version of long wave theory, the book’s interpretation of Karl Marx, its analysis of the Grundrisse’s “Fragment on Machines”, and aspects of political struggles and societal change. The conclusion is that Paul Mason is digital Marxism’s Henryk Grossmann 2.0.

Pope John Paul II's Address to Black Catholics: A Motive Analysis.

Science.gov (United States)

Costanza, Jean M.

Pope John Paul's visit to the United States in 1987 provided many opportunities for the analysis of papal rhetoric. The Pope's address to black Catholics in America may be of particular interest to those focusing on the study of intercultural or interracial communication. This address did not garner as much media attention as did some of the…

The Sagnac effect and its interpretation by Paul Langevin

Science.gov (United States)

Pascoli, Gianni

2017-11-01

The French physicist Georges Sagnac is nowdays frequently cited by the engineers who work on devices such as ring-laser gyroscopes. These systems operate on the principle of the Sagnac effect. It is less known that Sagnac was a strong opponent to the theory of special relativity proposed by Albert Einstein. He set up his experiment to prove the existence of the aether discarded by the Einsteinian relativity. An accurate explanation of the phenomenon was provided by Paul Langevin in 1921.

Pb isotope analysis of ng size samples by TIMS equipped with a 1013 Ω resistor using a 207Pb-204Pb double spike

NARCIS (Netherlands)

Klaver, M.; Smeets, R.J.; Koornneef, J.M.; Davies, G.R.; Vroon, P.Z.

2016-01-01

The use of the double spike technique to correct for instrumental mass fractionation has yielded high precision results for lead isotope measurements by thermal ionisation mass spectrometry (TIMS), but the applicability to ng size Pb samples is hampered by the small size of the

EnviroAtlas - Minneapolis/St. Paul, MN - Meter-Scale Urban Land Cover (MULC) Data (2010)

Data.gov (United States)

U.S. Environmental Protection Agency — The Minneapolis-St. Paul, MN EnviroAtlas Meter-scale Urban Land Cover (MULC) data were generated from four-band (red, green, blue, and near infrared) aerial...

SEM/TIMS analysis trials on hotswipe samples taken from a shielded cell at Harwell

International Nuclear Information System (INIS)

Tushingham, J.; Vatter, I.; Cooke, R.

1998-09-01

The IAEA require advanced techniques and procedures for the detection of traces of actinides to be applied to their environmental sampling programme for nuclear safeguards as a means to detect undeclared activities. 'Swipe' samples taken from within nuclear facilities by IAEA inspectors require analysis to determine their actinide content and composition by bulk and particle measurements. The use of analytical equipment capable of analysing individual particles, particularly of actinides, is essential to optimise the IAEA's aim to monitor Member State's nuclear activities more proficiently. A trial has been undertaken at the Harwell Laboratory of AEA Technology to establish the efficacy of scanning electron microscopy (SEM) and thermal ionisation mass spectrometry (TIMS) for the particle and bulk characterisation, respectively, of actinides on samples taken from within a shielded cell. These measurements were supported by γ-spectrometry and α-spectrometry. 'Hotswipe' samples taken from within a shielded cell with a well-known recent history have been prepared for particle and bulk analysis. SEM has been used to characterise individual particles from the swipe samples and the results have been related to known cell activities. Samples were prepared for SEM using a simple procedure to minimise the potential for sample contamination. The method proved to be capable of identifying 1 μm particles that contained U, Pu, Pa and Np. The measurement of U/Pu ratios was limited to particles that contained >2% Pu in U by weight. TIMS, together with alpha spectrometry, has been used to determine the bulk actinide composition of the samples whilst gamma spectrometry has been used to determine the fission product composition. Further work to improve the potential of SEM, and also secondary ionisation mass spectrometry (SIMS), for the measurement of hotswipe samples has been proposed. (author)

Towards unsupervised polyaromatic hydrocarbons structural assignment from SA-TIMS-FTMS data.

Science.gov (United States)

Benigni, Paolo; Marin, Rebecca; Fernandez-Lima, Francisco

2015-10-01

With the advent of high resolution ion mobility analyzers and their coupling to ultrahigh resolution mass spectrometers, there is a need to further develop a theoretical workflow capable of correlating experimental accurate mass and mobility measurements with tridimensional candidate structures. In the present work, a general workflow is described for unsupervised tridimensional structural assignment based on accurate mass measurements, mobility measurements, in silico 2D-3D structure generation, and theoretical mobility calculations. In particular, the potential of this workflow will be shown for the analysis of polyaromatic hydrocarbons from Coal Tar SRM 1597a using selected accumulation - trapped ion mobility spectrometry (SA-TIMS) coupled to Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS). The proposed workflow can be adapted to different IMS scenarios, can utilize different collisional cross-section calculators and has the potential to include MS n and IMS n measurements for faster and more accurate tridimensional structural assignment.

The leadership challenges of Paul�s collection for the saints in Jerusalem: Part II: Overcoming the obstacles on the side of the recipients and of Paul

Directory of Open Access Journals (Sweden)

Christoph W. Stenschke

2017-01-01

Full Text Available Paul tried to convince the predominantly Gentile Christian churches to contribute to a collection for the impoverished Jewish Christians of Jerusalem. While Paul is best known as a theologian, missionary and pastor, his collection project also shows his skills as an early Christian leader. Part II of this article describes what obstacles Paul had to overcome on the side of the Jewish Christian recipients of the collection, how he did so and how he proceeded in preparing and organising the actual collection, the transport and presentation of the funds in Jerusalem. It also discusses what obstacles were involved for Paul personally in this project and how he dealt with them. In closing, the article relates the portrait of Paul the leader as it emerges in this enterprise to modern leadership theory. Paul�s leadership evinces elements of servant leadership, authentic leadership and adaptive leadership.Intradisciplinary and/or interdisciplinary implications: The article indicates to what extent early Christianity was affected by and had to interact with the political situation of its day. It also shows the complexities of Paul�s life and ministry and his relations to the church in Jerusalem. It also provides an example of how Paul can be related to current leadership theory and suggests that awareness of this discourse sheds fresh light on Paul.

Asthenospheric percolation of alkaline melts beneath the St. Paul region (Central Atlantic Ocean)

Science.gov (United States)

Brunelli, Daniele; Seyler, Monique

2010-01-01

Two peridotite suites collected by submersible in the equatorial Atlantic Ocean (Hekinian et al., 2000) were studied for textures, modes, and in situ major and trace element compositions in pyroxenes. Dive SP12 runs along the immersed flank of the St. Peter and Paul Rocks islets where amphibole-bearing, ultramafic mylonites enriched in alkalies and incompatible elements are exposed (Roden et al., 1984), whereas dive SP03 sampled a small intra-transform spreading centre situated about 370 km east of the St. Peter and Paul Rocks. Both suites are characterized by undeformed, coarse-grained granular textures typical of abyssal peridotites, derived from residual mantle after ˜ 15% melting of a DMM source, starting in the garnet stability field. Trace element modelling, textures and lack of mineral zoning indicate that the residual peridotites were percolated, reacted and refertilized by ˜ 2.6% partially aggregated melts in the uppermost level of the melting region. This relatively large amount of refertilization is in agreement with the cold and thick lithosphere inferred by previous studies. Freezing of trapped melts occurred as the peridotite entered the conductive layer, resulting in late-stage crystallization of olivine, clinopyroxene, spinel, ± plagioclase. Chondrite-normalized REE patterns in clinopyroxenes from SP03 indicate that they last equilibrated with (ultra-) depleted partial melts. In contrast, REE concentrations in clinopyroxenes from SP12 display U and S shaped LREE-enriched patterns and the calculated compositions of the impregnating melts span the compositional range of the regional basalts, which vary from normal MORB to alkali basalt sometimes modified by chromatographic fractionation with no, or very limited, mineral reaction. Thus the mylonitic band forming the St. Peter and St. Paul Rocks ridge is not a fragment of subcontinental lithospheric mantle left behind during the opening of the Central Atlantic, nor the source of the alkaline basalts

Transformation in love in Paul's letter to the Galatians | de Villiers ...

African Journals Online (AJOL)

Paul's Letter to the Galatians is known as a bitter defence of his “true” gospel of faith against opponents who wish to impose their “false” gospel of works on the faith community. This focus on the faith-works controversy has not been conducive to attempts to read it in terms of the notion of love. This article seeks to reconsider ...

Excerpts from Vatican's "Veritatis Splendor," Pope John Paul II's Views of Moral Truth.

Science.gov (United States)

Chronicle of Higher Education, 1993

1993-01-01

Excerpts are presented from a recent papal encyclical that sets forth John Paul II's views on timeless moral truths and on dissent from them within the Roman Catholic Church. The responsibility of bishops to monitor Catholic institutions, including educational institutions, is noted. (MSE)

Laser-Induced Fluorescence diagnostic of barium ion plasmas in the Paul Trap Simulator Experiment

International Nuclear Information System (INIS)

Chung, Moses; Gilson, Erik P.; Davidson, Ronald C.; Efthimion, Philip C.; Majeski, Richard; Startsev, Edward A.

2005-01-01

The Paul Trap Simulator Experiment (PTSX) is a cylindrical Paul trap whose purpose is to simulate the nonlinear dynamics of intense charged particle beam propagation in alternating-gradient magnetic transport systems. To investigate the ion plasma microstate in PTSX, including the ion density profile and the ion velocity distribution function, a laser-induced fluorescence diagnostic system is being developed as a nondestructive diagnostic. Instead of cesium, which has been used in the initial phase of the PTSX experiment, barium has been selected as the preferred ion for the laser-induced fluorescence diagnostic. A feasibility study of the laser-induced fluorescence diagnostic using barium ions is presented with the characterization of a tunable dye laser. The installation of the barium ion source and the development of the laser-induced fluorescence diagnostic system are also discussed

A retrospective diagnosis of epilepsy in three historical figures: St Paul, Joan of Arc and Socrates.

Science.gov (United States)

Muhammed, Louwai

2013-11-01

It has been suggested that undiagnosed epilepsy profoundly influenced the lives of several key figures in history. Historical sources recounting strange voices and visions may in fact have been describing manifestations of epileptic seizures rather than more supernatural phenomena. Well-documented accounts of such experiences exist for three individuals in particular: Socrates, St Paul and Joan of Arc. The great philosopher Socrates described a 'daimonion' that would visit him throughout his life. This daimonion may have represented recurrent simple partial seizures, while the peculiar periods of motionlessness for which Socrates was well known may have been the result of co-existing complex partial seizures. St Paul's religious conversion on the Road to Damascus may have followed a temporal lobe seizure which would account for the lights, voices, blindness and even the religious ecstasy he described. Finally, Joan of Arc gave a detailed narrative on the voices she heard from childhood during her Trial of Condemnation. Her auditory hallucinations appear to follow sudden acoustic stimuli in a way reminiscent of idiopathic partial epilepsy with auditory features. By analysing passages from historical texts, it is possible to argue that Socrates, St Paul and Joan of Arc each had epilepsy.

Second NASA Technical Interchange Meeting (TIM): Advanced Technology Lifecycle Analysis System (ATLAS) Technology Tool Box (TTB)

Science.gov (United States)

ONeil, D. A.; Mankins, J. C.; Christensen, C. B.; Gresham, E. C.

2005-01-01

The Advanced Technology Lifecycle Analysis System (ATLAS), a spreadsheet analysis tool suite, applies parametric equations for sizing and lifecycle cost estimation. Performance, operation, and programmatic data used by the equations come from a Technology Tool Box (TTB) database. In this second TTB Technical Interchange Meeting (TIM), technologists, system model developers, and architecture analysts discussed methods for modeling technology decisions in spreadsheet models, identified specific technology parameters, and defined detailed development requirements. This Conference Publication captures the consensus of the discussions and provides narrative explanations of the tool suite, the database, and applications of ATLAS within NASA s changing environment.

Towards Clean Diesel Engines. Second Symposium. Book of Abstracts.

Science.gov (United States)

1998-04-06

E-Mail: choelle@bmw.co.at Rudolf HOLTBECKER R&D KoSt 7055 Wärtsilä NSD Switzerland Ltd. Postfach 414 CH-8401 Winterthur Switzerland Tel.: +41...49-5362 267 E-Mail: tim.strauss@volkswagen.de C. M. I. SPAANJAARS Dept. of Molecular + Laser Physics Rudolf STRUIS University of Nijmegen Paul...365 3017 Fax: +41-56-310 2199 Fax: +31-24-365 3311 E-Mail: struis@psi.ch E-Mail: charless@sci.kun.nl Gerrit SUCK Tobias STEINER Konzernforschung K

Propuesta del programaS-GeMS para el análisis estadístico espacial de fallas en alimentadores soterrados de 13,8 kV; PropodedS-GEMS program for statistical analysis of failure space of 13.8 kV underground feeders

Directory of Open Access Journals (Sweden)

Boris Alba Valle

2011-06-01

Full Text Available Actualmente, el sistema soterrado de Ciudad de La Habana, carece de herramientas gráficas de trabajo con lascuales poder visualizar zonas con alta incidencia de fallas en alimentadores de 13,8 kV y que permitan tomardecisiones certeras en cuanto a los tramos de alimentadores a reparar o sustituir por su deterioro. En este trabajo sepropone el uso de los programas S-GeMS (Stanford Geostatistical Modeling Software y Autocad comoherramientas para el análisis estadístico espacial de la cantidad de fallas. Se realiza, en lo fundamental, el estudiode toda la documentación referente a las aplicaciones del programa S-GeMS y la Base de Datos de la cantidad defallas del 2007 al 2009, de los alimentadores de 13,8 kV perteneciente a la Unidad Empresarial Básica (UEBSoterrada. Finalmente se muestran, a modo de ejemplo, los resultados obtenidos con su aplicación al determinarsela dirección preferencial de distribución de la cantidad de fallas.   Nowadays, the Havana City underground system, lacks of graphical working tools which not only allow to visualizehigh faults incidence areas in 13,8 kV feeders but also make good decisions in reference to the feeder sections to berepaired or substituted due to their impairment. The use of S-GeMS (Stanford Geostatistical Modeling Software andAutocad programs as tools for the spatial statistic analysis of faults quantity is proposed in this article. The study ofthe whole documentation related to the S-GeMS program applications is carried out as well as the UndergroundManagement Basic Unit (UEB 13,8 kV feeders faults quantity database from 2007 to 2009. Finally, the results afterdetermining the faults quantity distribution preferential address with the program application are shown, as anexample.

Criterio de predicción de la vida útil de la prótesis total de cadera en función de la falla del cemento en el componente femoral. // Life prediction criteria of hip prosthesis according to cement failure in femoral component.

Directory of Open Access Journals (Sweden)

G. García del pino

2002-09-01

Full Text Available En este trabajo se utiliza el Método de los Elementos Finitos para estudiar la combinación de diferentes parámetros, y suinfluencia en la vida útil de la prótesis total de cadera utilizando como criterio la falla del cemento que une estas prótesis alfémur, debido a que este tipo de falla es una de las fallas que mas provoca la perdida de la implantación. Los parámetrosestudiados aquí fueron el tipo de material del vástago de la prótesis dado por su modulo de elasticidad, la calidad del huesodada por la densidad y las cargas simulando diferentes actividades físicas y diferentes pesos del cuerpo.Los resultados obtenidos a través del Método de los Elementos Finitos, fueron procesados utilizando rutinas creadas enlenguaje C y técnicas de estadística, determinando las variables más influyentes y los valores más favorables para obteneruna transmisión apropiada de cargas, que garanticen una vida útil mayor.Palabras claves: biomecánica, ortopedia, elementos finitos, modulación__________________________________________________________________AbstractIn this paper the Finite Element Method is employ in order to study different parameters combination and their influence inthe duration of total hip prosthesis, taking as decision criteria the failure of cement that keep together femur and prosthesis,taking in account that this is the most common cause of implantation lost. The target parameters were: shank prosthesismaterial given by elasticity modulus, bone quality given by density, and finally, loads simulating different physicalactivities and body weight. The results were processed by means of statistical techniques and C language routines allowingto obtain the more influent variables to a proper load transmission and greater useful prosthesis life.Key words: Biomechanics, orthopaedic, finite elements, modulation

Propuesta del programa S-GeMS para el análisis estadístico espacial de fallas en alimentadores soterrados de 13,8 kV;PropodedS-GEMS program for statistical analysis of failure space of 13.8 kV underground feeders

Directory of Open Access Journals (Sweden)

Boris Alba - Valle

2011-06-01

Full Text Available Actualmente, el sistema soterrado de Ciudad de La Habana, carece de herramientas gráficas de trabajo con lascuales poder visualizar zonas con alta incidencia de fallas en alimentadores de 13,8 kV y que permitan tomardecisiones certeras en cuanto a los tramos de alimentadores a reparar o sustituir por su deterioro. En este trabajo sepropone el uso de los programas S-GeMS (Stanford Geostatistical Modeling Software y Autocad comoherramientas para el análisis estadístico espacial de la cantidad de fallas. Se realiza, en lo fundamental, el estudiode toda la documentación referente a las aplicaciones del programa S-GeMS y la Base de Datos de la cantidad defallas del 2007 al 2009, de los alimentadores de 13,8 kV perteneciente a la Unidad Empresarial Básica (UEBSoterrada. Finalmente se muestran, a modo de ejemplo, los resultados obtenidos con su aplicación al determinarsela dirección preferencial de distribución de la cantidad de fallas.Nowadays, the Havana City underground system, lacks of graphical working tools which not only allow to visualizehigh faults incidence areas in 13,8 kV feeders but also make good decisions in reference to the feeder sections to berepaired or substituted due to their impairment. The use of S-GeMS (Stanford Geostatistical Modeling Software andAutocad programs as tools for the spatial statistic analysis of faults quantity is proposed in this article. The study ofthe whole documentation related to the S-GeMS program applications is carried out as well as the UndergroundManagement Basic Unit (UEB 13,8 kV feeders faults quantity database from 2007 to 2009. Finally, the results afterdetermining the faults quantity distribution preferential address with the program application are shown, as anexample.

C++ FOR PARTICLE PHYSICISTS By Paul Kunz

CERN Document Server

TECHNICAL TRAINING; Tel. 74460

2001-01-01

Please note that Paul Kunz will be giving his very popular and highly recommended C++ course again on March 5 to 9. The course costs 200 CHF, and advance registration is required. People with CERN EDH accounts can apply electronically directly from the Web course description page : http://www.cern.ch/Training/ENSTEC/P9798/Software/cpppp_e.htm Team Visitors should ask their Group Leader to send an e-mail to the DTO of EP Division, M. Burri, referring to the 'C++ for Particle Physicists' course and giving their name, CERN ID number, the Team account number to which the course fee should be charged, and VERY IMPORTANTLY an email address to which an invitation to the course can be sent.

C++ FOR PARTICLE PHYSICISTS by Paul Kunz

CERN Document Server

Technical Training; Tel. 74460

2001-01-01

Please note that Paul Kunz will be giving his very popular and highly recommended C++ course again on March 5 to 9. The course costs 200 CHF, and advance registration is required. People with CERN EDH accounts can apply electronically directly from the Web course description page : http://www.cern.ch/Training/ENSTEC/P9798/Software/cpppp_e.htm Team Visitors should ask their Group Leader to send an e-mail to the DTO of EP Division, M. Burri, referring to the 'C++ for Particle Physicists' course and giving their name, CERN ID number, the Team account number to which the course fee should be charged, and VERY IMPORTANTLY an email address to which an invitation to the course can be sent.

Epistemological anarchism of Paul Karl Feyerabend and medical education

Directory of Open Access Journals (Sweden)

Andréia Patrícia Gomes

Full Text Available The thoughts of the philosopher Paul Karl Feyerabend brought important contributions to the debate on Science in the 20th century. Most recently his views about non-existence of a single method for doing science have been employed to rethink science education and propose the use of multiple methods for effective teaching-learning process. This article employs the theoretical framework of the author expressed in the book Against Method, 1977, about the epistemological anarchism and the methodological pluralism and uses it in the contemporary discussion of medical education.

The angle of incidence of Paul Roux's catechism - a study on the ...

African Journals Online (AJOL)

With the Belijdenis of Paul Roux we have an indigenous document of early eighteenth century theological reflection among some French refugees of the first generations at the Cape. It provides us with useful opportunities to analyse the theology of an important part of the history of the Huguenots. In this study, attention is ...

The Lukan periplus of Paul's third journey with a textual conundrum ...

African Journals Online (AJOL)

A lexical discussion of ἄντικρυς Χίου is presented, and possible translations are reviewed. The article presents a new hypothesis that the Ionian city of Erythrae was the place of the ship's landing. It closes with a brief history of Erythrae's significance in the Greco-Roman world and why a stop there by Paul's coasting vessel ...

Paul Tillich and psychoanalysis.

Science.gov (United States)

Hart, Curtis W

2011-09-01

Paul Tillich (1886-1965) was one of the leading theologians of the twentieth century. Tillich was born in Germany and received his education and first academic appointments there. Tillich left Germany in 1933 to teach at Union Theological Seminary after having been dismissed from his university position by the National Socialist government for his radical views and political associations. In the United States, he became a highly successful lecturer, preacher, and public intellectual who reached numbers of persons who had departed or who had doubts regarding traditional religious belief and practice. Tillich underwent a series of traumatic losses in the early decades of his life that powerfully shaped his subsequent contributions to religious and cultural discourse. This essay outlines this pattern of loss and speculates about its impact upon his theological work. It lifts up Tillich's perspective of living and working "on the boundary" of disciplines, eras, and cultures, most particularly where psychoanalytic ideas contributed to his "theology of culture." It also stresses Tillich's role in initiating the ongoing dialogue between religion and psychiatry and psychoanalysis. The essay concludes with a summary critique of Tillich's work along with an affirmation of his considerable legacy. This essay was originally a presentation for the Richardson Research Seminar in the History of Psychiatry at Weill Cornell Medical College.

Smoke (Paul Auster et Wayne Wang, 1995 : une œuvre à la croisée des arts

Directory of Open Access Journals (Sweden)

Delphine Letort

2011-04-01

Full Text Available The adaptation of the short story entitled “Auggie Wren’s Christmas Story” (1990 gathered the writer Paul Auster and the director Wayne Wang around a film project that allowed them to share their artistic practices in a collaborative work. This paper examines the question that underpins the narrative of the short-story by grappling with the appropriations of the real in other artistic modes. Paul Auster’s first encounter with the cinema points out the convergence between aural writing and cinematic writing, evoked through the double figure of the writer and that of the tale-teller/photographer in both the film and the short story.L’adaptation de la nouvelle « Auggie Wren’s Christmas Story » (1990 réunit l’écrivain Paul Auster et le réalisateur Wayne Wang autour d’un projet qui leur permit de croiser leurs pratiques artistiques dans un travail de collaboration. Cet article prolonge le questionnement artistique qui sous-tend le récit de la nouvelle en interrogeant les modalités de l’appropriation du réel par d’autres arts. La première rencontre entre Paul Auster et le cinéma met en relief les points de convergence entre écriture verbale et écriture cinématographique, évoqués autour de la double figure de l’écrivain et du conteur/photographe dans le film et dans la nouvelle.

Inhibición dual de la neprilisina y del receptor de la angiotensina (ARNI: una alternativa en los pacientes con falla cardiaca

Directory of Open Access Journals (Sweden)

Beatriz Wills

2016-03-01

Full Text Available La falla cardiaca (FC es la causa más común de admisión hospitalaria en adultos en el mundo. Además, de su importante prevalencia la FC tiene un alta tasa de mortalidad, se estima que aproximadamente el 50% de los pacientes con FC mueren a los 5 años posterior al egreso hospitalario. Esto ha motivado el desarrollo de nuevas terapias seguras y efectivas para el manejo de esta entidad. El LCZ696 es un inhibidor dual de la neprilisina y del receptor de angiotensina II que demostró en estudios de fase III disminuir el desenlace primario de muerte cardiovascular y hospitalización por empeoramiento de la FC y muerte global. Probablemente el LCZ696 se convertirá en la piedra angular del manejo en pacientes con FC con fracción de eyección deprimida.

200 Paul and Hard Work (2 Thessalonians 3:6-10): A Christian ...

African Journals Online (AJOL)

the developmental conditions in the land and such is the endeavour of this work as Paul's ... intellectual works, articulation of ethical principles, religion, politics and trade. Thus, the .... avoid any loafer in the system because such were walking in disorder, τάκτως .... mine) Africans and other such parts of the world. Ejiogu in ...

“Whatever gain I had ...”: Ethnicity and Paul's self-identification in ...

African Journals Online (AJOL)

This study is not an exercise in Vernon Robbin's groundbreaking socio-rhetorical criticism as put forth in his impressive The Tapestry of Early Christian Discourse and Exploring the Texture of Texts. It does have much in common with his “social and cultural texture”. It also touches “inner texture” in relation to Paul's implied ...

Expression profiles and clinical value of plasma exosomal Tim-3 and Galectin-9 in non-small cell lung cancer.

Science.gov (United States)

Gao, Jianwei; Qiu, Xiangyu; Li, Xinying; Fan, Hang; Zhang, Fang; Lv, Tangfeng; Song, Yong

2018-04-06

Exosomes are membrane-bound, virus-sized vesicles present in circulating blood. Tumor cells are avid producers of exosomes, which are thought to mimic molecular features of parent tumor cells. T-cell immunoglobulin- and mucin-domain-containing molecule 3 (Tim-3) is a the next-generation immune checkpoint that can be activated by its ligand Galectin-9 to negatively regulate the anti-tumor immune response. However, the characteristics of plasma exosomal Tim-3 and Galectin-9 (Exo-T/G) in cancer remained unknown. This study was conducted to investigate the expression patterns and clinical value of plasma exosomal total protein (Exo-pro) and Exo-T/G in non-small cell lung cancer (NSCLC). Plasma was collected from 103 NSCLC patients including 60 early stages and 43 advanced stages disease samples as well as 56 healthy subjects. Exosomes were isolated from plasma by commercial exosome precipitation solution and identified by western blotting of CD63 and transmission electron microscopy. Exo-pro concentration was measured by the BCA assay. Enzyme-linked immunosorbent assay was used to quantify Exo-T/G. Additionally, 34 NSCLC samples were applied to directly detect plasma TIM-3 (Plas-T) and Galectin-9 (Plas-G). Our results showed that Exo-pro, Exo-T, and Exo-G were significantly increased in NSCLC plasma compared to that in the healthy samples. High levels of Exo-T and Exo-G were all positively correlated with several malignant parameters, including larger tumor size, advanced stages, and more distant metastasis. High levels of Exo-pro and Exo-T were also correlated with more lymph node metastasis. Additionally, plasma from lung squamous cell carcinoma showed higher Exo-T and Exo-G compared with that from lung adenocarcinoma. ALK-positive patients showed to have decreased Exo-T and Exo-G levels. Pearson's correlation analysis revealed a significant correlation between Exo-pro and Exo-T/G, Exo-T and Exo-G, Exo-T and Plas-T, Exo-G and Plas-G, and Plas-T and Plas-G. Together

Creator of Economic Opera, Founder and Reformer of Economic School – the Rector Paul Bran

Directory of Open Access Journals (Sweden)

Ghenadie Ciobanu

2014-05-01

Full Text Available Phd. Prof. Paul Bran (1940-2006, during the mandates of rector of the Bucharest University of Economic Studies (1996-2004 and beyond, although financier proved close to the Faculty of Commerce. In 2001, at the jubilee of the uninterrupted operation of the faculty, he stated: We join alumni, students and professors of the Faculty of Commerce to pay tribute to the work of learning and education that takes place here and to honor those who have established and then strengthened higher economic education in trade, marketing, tourism and commodity. I am convinced that the reputation of the Bucharest University of Economic Studies is due mainly to the quality of the activities taking place in departments and laboratories of the Faculty of Commerce.” On another occasion, the dedication on a book, he wrote: “Because tourism lives by money and money through tourism.” There are only two instances, seemingly unimportant, but which can be multiplied to the whole of his professional career of over four decades, and they shows us the Professor and Rector Paul Bran – both charismatic and effective – as a friend of the Faculty of Commerce. “Sincere congratulations and best wishes on the first issue of the journal Amfiteatru Economic,” said Rector Paul Bran, visionary, on the cover of the first issue of our publication, in 1999.

La definición de usos del suelo en las cercanías de fallas geológicas: explicación del Protocolo Técnico del Decreto Ejecutivo 32967 - MINAE, Anexo 3

OpenAIRE

Allan Astorga-Gätgens

2013-01-01

Se realiza una explicación técnica sobre el Protocolo Técnico publicado como Decreto Ejecutivo (32967 - MINAE, Anexo 3). El Protocolo se refiere a la definición de los usos del suelo en las cercanías de fallas geológicas inactivas, activas y potencialmente activas. Aparte de aclarar la nomenclatura técnica, se explica el procedimiento que debe seguir el profesional en geología para establecer las eventuales zonas de seguridad que deben respetarse al momento de definir los usos del suelo, en p...

Paul Cefalu. Revisionist Shakespeare: Transitional Ideologies in Texts and Contexts

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Rainer EMIG

2006-06-01

Full Text Available Paul Cefalu, Assistant Professor of English at Lafayette College, offers five essays, three of which have previously appeared in different versions in periodicals, in this stimulating, but also sometimes puzzling and even frustrating book. That he aims for a revision of the core of Shakespearean Studies is already evident in his choice of objects for his analysis: The Tempest, Coriolanus, The Merchant of Venice, King Lear, and Hamlet. Yet “revisionist” is only implicitly applied to Cefalu's o...

Mission and Ethics in 1 Corinthians: Reconciliation, corporate solidarity and other-regard as missionary strategy in Paul

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Jacobus Kok

2012-06-01

Full Text Available In this article the dynamic relationship between mission and ethics in contexts of conflict and change in the Corinthian correspondence was investigated, and the role Paul played as reconciling leader, examined. The early Christian writers like Paul wanted to instruct and shape communities of faith. Paul was especially concerned with the maintenance and growth of his congregations and also with the social and ethical boundaries between the community of faith and the ‘world’. In the article it was illustrated that within the Corinthian congregational context there existed several conflict situations, and that much of it was a result of diversity within the congregation. Diversity is a fact of life and reality of the church. In Paul’s vision for unity and reconciliation, and in his attempt to address the factionalism in the Corinthian congregation, he would in all cases, ground his practical solution in a theological identity construction. Paul focuses on corporate solidarity and unity and urges the congregation to find their fellow brothers and sisters in times of conflict by means of ethical reciprocity and other-regard, a matter in which he is also an example, typical of other philosophers of his time – but with a significant difference. At the end it becomes clear that Paul’s ethical advice has a missional dimension, in the sense that the conflict management should take place in such a way that God is honoured and that both Jews, Greeks and fellow believers will see that the way this community handles conflict, is different to the way the ‘world’ would do it, and that in the process, even more might be saved.

A CONSTITUIÇÃO DO SUJEITO: UMA REFLEXÃO A PARTIR DE JEAN-PAUL SARTRE

Directory of Open Access Journals (Sweden)

Lúcia Cecília da Silva

2017-05-01

this object of study has difficulties, which are evident in the different approaches to it, either objectivist or subjectivist ones. In order to contribute to such discussion, this study aims at analyzing how the existentialism of Jean-Paul Sartre approaches the processes of the constitution of the subject. The Sartrean perspective enriches Psychology because, by rejecting reductionisms, it offers a conception that does not dichotomize the phenomenon of objectification-subjectification, since it conceives the subject in the dialectical relation between objectivity and subjectivity. Sartre does not only suggest elements to understand body, consciousness and the world as a human and historical reality, but also elucidates how the subject, who is forged in intersubjectivity, constructs his/her personal and collective history. Keywords: psychology; constitution of the subject; existentialism; Jean-Paul Sartr

77 FR 45965 - Determination of Attainment for the Paul Spur/Douglas PM10

Science.gov (United States)

2012-08-02

... Paul Spur/Douglas NA covers approximately 220 square miles along the border with Mexico within Cochise... Pirtleville, 2010 population 1,744, (U.S. Census). The 2010 population of Agua Prieta, Mexico, just across the border from Douglas, is 78,138 (Instituto Nacional de Estadistica y Geografia). To summarize our proposed...

Mini-DIAL system measurements coupled with multivariate data analysis to identify TIC and TIM simulants: preliminary absorption database analysis

International Nuclear Information System (INIS)

Gaudio, P; Malizia, A; Gelfusa, M; Poggi, L.A.; Martinelli, E.; Di Natale, C.; Bellecci, C.

2017-01-01

Nowadays Toxic Industrial Components (TICs) and Toxic Industrial Materials (TIMs) are one of the most dangerous and diffuse vehicle of contamination in urban and industrial areas. The academic world together with the industrial and military one are working on innovative solutions to monitor the diffusion in atmosphere of such pollutants. In this phase the most common commercial sensors are based on “point detection” technology but it is clear that such instruments cannot satisfy the needs of the smart cities. The new challenge is developing stand-off systems to continuously monitor the atmosphere. Quantum Electronics and Plasma Physics (QEP) research group has a long experience in laser system development and has built two demonstrators based on DIAL (Differential Absorption of Light) technology could be able to identify chemical agents in atmosphere. In this work the authors will present one of those DIAL system, the miniaturized one, together with the preliminary results of an experimental campaign conducted on TICs and TIMs simulants in cell with aim of use the absorption database for the further atmospheric an analysis using the same DIAL system. The experimental results are analysed with standard multivariate data analysis technique as Principal Component Analysis (PCA) to develop a classification model aimed at identifying organic chemical compound in atmosphere. The preliminary results of absorption coefficients of some chemical compound are shown together pre PCA analysis. (paper)

social equality and christian life in paul's first letter to the corinthians

African Journals Online (AJOL)

Schmeller 1995:92ff.). In this letter, Paul contends with theologically motivated schisms .... Ἰουδαῖοι and Ἕλλην embody, in their equality, certain attitudes (also in the .... but as a salvific ownership change with Christ as the new patron.20 The ... concept of the adult male, who is rational, moderate, and able to transcend.

Role of the import motor in insertion of transmembrane segments by the mitochondrial TIM23 complex.

Science.gov (United States)

Popov-Čeleketić, Dušan; Waegemann, Karin; Mapa, Koyeli; Neupert, Walter; Mokranjac, Dejana

2011-06-01

The TIM23 complex mediates translocation of proteins across, and their lateral insertion into, the mitochondrial inner membrane. Translocation of proteins requires both the membrane-embedded core of the complex and its ATP-dependent import motor. Insertion of some proteins, however, occurs in the absence of ATP, questioning the need for the import motor during lateral insertion. We show here that the import motor associates with laterally inserted proteins even when its ATPase activity is not required. Furthermore, our results suggest a role for the import motor in lateral insertion. Thus, the import motor is involved in ATP-dependent translocation and ATP-independent lateral insertion.

Église Saint-Pierre-Saint-Paul, Appoigny (Yonne

Directory of Open Access Journals (Sweden)

Fabrice Henrion

2009-09-01

Full Text Available L’église Saint-Pierre-Saint-Paul d’Appoigny témoigne d’un important chantier du début du XIIIe siècle , mais les sources permettent d’envisager la présence d’un sanctuaire au moins depuis l’extrême fin du VIe siècle. En effet, le règlement liturgique établit par Aunaire, évêque d’Auxerre de 561 à 604, mentionne Epponiacus dans la liste des sanctuaires auxerrois, sans que le vocable de l’église d’Appoigny ne soit précisé. Par ailleurs, depuis au moins le IXe siècle, une tradition, reprise par ...

An Analysis of "City of Glass" by Paul Auster in Terms of Postmodernism

Science.gov (United States)

Odacioglu, Mehmet Cem; Loi, Chek Kim; Çoban, Faddime

2017-01-01

This study analyzes "City of Glass," a postmodernist detective novella (or anti-detective) of the "New York Trilogy" by Paul Auster in terms of postmodernist elements and techniques such as metafiction, parody, intertextuality, irony and like. In doing so, some information about Auster's life and the plot of the work are also…

The particle analysis based on FT-TIMS technique for swipe sample under the frame of nuclear safeguard

International Nuclear Information System (INIS)

Yang Tianli; Liu Xuemei; Liu Zhao; Tang Lei; Long Kaiming

2008-06-01

Under the frame of nuclear safeguard, the particles analysis for swipe sample is an advance mean to detect the undeclared uranium enriched facilities and undeclared uranium enriched activity. The technique of particle analysis based on fission track-thermal ionization mass spectrometry (FT-TIMS) for swipe sample have been built. The reliability and the experimental background for selecting particles consisting of uranium from swipe sample by FT method have been verified. In addition, the utilization coefficient of particles on the surface of swipe sample have also been tested. These works have provided the technique support for application in the area of nuclear verification. (authors)

PSI Paul Scherrer Institute

International Nuclear Information System (INIS)

Lefrancois, M.; Pladys, D.

2008-05-01

From research activities focused on civil and military uses of nuclear energy and developed after the second world war, the Paul Scherrer Institute (PSI) has been able to diversify its activities following 2 axis. First, the Gantry proton-therapy that is characterized by a compact equipment and an accurate 3-dimensional treatment of tumors (more than 260 patients have been treated by Gantry from 1996 to 2005). Secondly, new technologies in the fields of energy and transport. Nevertheless, PSI has been able to keep a high of valuation of its staff in nuclear engineering and materials that are the core of its activities. The main equipment of PSI are: -) SLS (Swiss Light Source): a synchrotron radiation source that is both a microscope and an X-ray source; -) SINQ: a neutron source based on spallation reactions; -)SμS: a muon source; and -) the Philips accelerator that is used in radiochemistry and the production of isotopes used for the treatment of eye tumors. PSI has established a large cooperation with French research laboratories on issues like: nuclear reactor safety, synchrotron radiation, the transmutation of nuclear wastes, the design of a source of ultra-cold neutrons, or the development of a hydrogen-fueled light vehicle. The total budget of PSI for 2007 reached 174.2 million euros. (A.C.)

Paul Gauguin in Brittany

Science.gov (United States)

Asmus, John F.

2009-07-01

Ever since the dawn of the 20th Century there has been a universal consensus that Alphonse Mucha launched the sensation that became known as Art Nouveau. This event was associated with the appearance of his Gismonda poster promoting the Sarah Bernhardt play of that name in Paris in 1894. At an estate sale in 1954 a small collage bearing a likeness of Mucha's Gismonda was offered. It had been fabricated by gluing slivers cut from sixty postage stamps to a 20cm ceramic tile. Digital computer image enhancement was applied to the collage design, initials on a walking stick from the same estate collection, and the Mucha poster. These geometrical analyses revealed that the collage is more detailed than the Mucha "original". This led to our hypothesis that the famous poster was a hasty photographic plagiarism of the intricate ceramic-tile collage. Image analyses of the initials on the companion walking stick revealed conformity with the famous enigmatic "P GO" monogram of Paul Gauguin. We conclude that Gauguin rather than Mucha created the Gismonda composition. Historical evidence suggests that, while Gauguin was in Brittany recovering from injuries sustained in a fistfight, Annah la Javanese stole his possessions and took them to Paris where her next lover, Mucha, copied the collage and presented it as his original poster design.

"Of comics and men: A cultural history of American comic books," by Jean-Paul Gabilliet

Directory of Open Access Journals (Sweden)

Drew Morton

2013-06-01

Full Text Available Jean-Paul Gabilliet. Of comics and men: A cultural history of American comic books. Translated by Bart Beaty and Nick Nguyen. Jackson: University Press of Mississippi, 2010, hardcover, $55.00 (390p, ISBN 978-1604732672.

Inquiry and Irony: Promise and Paradox in Paul Jablon's "The Synergy of Inquiry"

Science.gov (United States)

Nurenberg, David

2016-01-01

Paul Jablon's "The Synergy of Inquiry" (2014) is well-timed. The 2014 deadline set by No Child Left Behind (NCLB, 2002) for universal student proficiency has come and gone, and according to the National Assessment of Educational Progress, "proficiency rates last year were below 50 percent for nearly every racial and ethnic group, in…

Fault detection in the electrical equipment of the artificial system, used for the oil production in marine platforms; Deteccion de fallas en los equipos electricos del sistema artificial, utilizado para la produccion de petroleo en plataformas marinas

Energy Technology Data Exchange (ETDEWEB)

Vargas H, Vicente; Rosales S, Inocente [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico); Pimentel M, Jorge [Petroleos Mexicanos (Mexico)

2007-07-01

At present, PEMEX is using new artificial pumping systems for the production of oil, specifically the Electro Centrifugal Pumping system (ECP). Nevertheless, during the operation of the (ECP) system problems by the failure of their electrical components have appeared, mainly of the equipment installed within the well. The faults have resulted in an increased cost for the diminution in the production and the maintenance cost of the remedial work. The maintenance personnel have procedures to perform verification tests of the conditions of the bottom electrical equipment. But, in the case of an electrical failure of the equipment, its location cannot be determined, since they are installed at 3,600 m from the production wellhead. In accordance with the former, the Instituto de Investigaciones Electricas proposed the application of the reflectometry technique in the time domain, to complement the maintenance procedures. This technique is a very useful diagnosis tool of the electrical equipment, which helps in the decision making of the maneuvers of preventive and corrective maintenance to be followed, with the consequent saving of resources. [Spanish] Actualmente, PEMEX esta utilizando nuevos sistemas artificiales de bombeo para la produccion de petroleo, en especifico el Sistema de Bombeo Electrocentrifugo (BEC). Sin embargo, durante la operacion del Sistema BEC se han presentado problemas por la falla de sus componentes electricos, sobre todo del equipo instalado dentro del pozo. Las fallas han resultado con un costo elevado por la disminucion en la produccion y por los trabajos de mantenimiento correctivo. El personal de mantenimiento cuenta con procedimientos para realizar pruebas de verificacion del estado de los equipos electricos de fondo. Pero, en el caso de una falla electrica de los equipos, no se puede determinar su ubicacion, dado que se instalan a 3,600 m del cabezal del pozo de produccion. De acuerdo con lo anterior, el Instituto de Investigaciones

An apology for dialogue: Claude Geffré reading Paul Tillich

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Joe Marçal Gonçalves dos Santos

2015-12-01

Full Text Available The subject of this article is Claude Geffré’s reading on Paul Tillich’s thought in De Babel a Pentecostes: ensaios de teologia inter-religiosa. The author relies on Tillich’s theology to develop an “inter-religious dialogue hermeneutics” in order to answer to the challenge that religious pluralism poses to Christian theology today. The argument that Geffré finds is that just based on the Christological paradox, in light of the concept of “final revelation” and “ultimate concern”, Christian theology can respond to the religious pluralism without losing itself. The article presents two parts: firstly, an overview of Geffré’s book, focusing on the first session entitled Não há outro nome, where our object of study is found. Secondly, we analyse Tillich’s concepts developed by Geffré in this chapter, aiming to identify and characterize the main results of this reading and analyse them in light of Tillich’s referential work. In conclusion, we highlight the relevance of Paul Tillich’s theology to deal with the problem of religious pluralism, what is also demonstrated by Geffré. Besides, we consider a criticism of Gefreé’s proposal regarding an inter-religious theology based on the concept of ultimate concern, whose implication questions the use of this concept for an inter-religious theology, as its paradoxical nature is relativized.