Ergonomic Evaluation of Space Shuttle Light-Weight Seat Lever Position and Operation

Science.gov (United States)

Maida, J.; Rajulu, Sudhakar L.; Bond, Robert L. (Technical Monitor)

2000-01-01

During a Shuttle flight in the early part of 1999, one of the crewmembers was unable to operate the backrest lever for the light-weight seat in microgravity. It is essential that the crewmembers are able to adjust this back-rest lever, which is titled forward 2 degrees from vertical during launch and then moved backwards to 10 degrees aft of vertical upon reaching orbit. This adjustment is needed to cushion the crewmembers during an inadvertent crash landing situation. The original Shuttle seats, which had seat controls located on the front left and right sides of the seat, were replaced recently with the new light-weight seats. The controls for these new, seats were moved to the night side with one control at the front and the other at the back. While it was uncertain whether the problem encountered was unique to that crewmember or not it was clear to the personnel responsible for maintaining the Shuttle seats that not knowing the cause of the problem posed a safety concern for NASA. Hence the Anthropometry and Biomechanics Facility (ABF) of the Johnson Space Center was requested to perform an evaluation of the seat controls and provide NASA with appropriate recommendations on whether the seat lever positions and operations should be modified. The ABF designed an experiment to investigate the amount of pull force exerted by subjects, wearing an unpressurized or pressurized crew launch escape suit, when controls were placed in the front and back (on the right side) of the light-weight seat. Single-axis load cells were attached to the seat levers, which measured the maximum static pull forces that were exerted by the subjects. Twelve subjects, six male and six female, participated in this study. Each subject was asked to perform the pull test at least three times for each combination of lever position and suit pressure conditions. The results from this study showed that as a whole (or in general), the subjects were able to pull on the lever at the back position with

The Effects of Lever Arm (Instrument Offset) Error on GRAV-D Airborne Gravity Data

Science.gov (United States)

Johnson, J. A.; Youngman, M.; Damiani, T.

2017-12-01

High quality airborne gravity collection with a 2-axis, stabilized platform gravity instrument, such as with a Micro-g LaCoste Turnkey Airborne Gravity System (TAGS), is dependent on the aircraft's ability to maintain "straight and level" flight. However, during flight there is constant rotation about the aircraft's center of gravity. Standard practice is to install the scientific equipment close to the aircraft's estimated center of gravity to minimize the relative rotations with aircraft motion. However, there remain small offsets between the instruments. These distance offsets, the lever arm, are used to define the rigid-body, spatial relationship between the IMU, GPS antenna, and airborne gravimeter within the aircraft body frame. The Gravity for the Redefinition of the American Vertical Datum (GRAV-D) project, which is collecting airborne gravity data across the U.S., uses a commercial software package for coupled IMU-GNSS aircraft positioning. This software incorporates a lever arm correction to calculate a precise position for the airborne gravimeter. The positioning software must do a coordinate transformation to relate each epoch of the coupled GNSS-IMU derived position to the position of the gravimeter within the constantly-rotating aircraft. This transformation requires three inputs: accurate IMU-measured aircraft rotations, GNSS positions, and lever arm distances between instruments. Previous studies show that correcting for the lever arm distances improves gravity results, but no sensitivity tests have been done to investigate how error in the lever arm distances affects the final airborne gravity products. This research investigates the effects of lever arm measurement error on airborne gravity data. GRAV-D lever arms are nominally measured to the cm-level using surveying equipment. "Truth" data sets will be created by processing GRAV-D flight lines with both relatively small lever arms and large lever arms. Then negative and positive incremental

Obituary: Edward R. (Ted) Harrison, 1919-2007

Science.gov (United States)

Irvine, William M.; Arny, Thomas T.; Trimble, Virginia

2007-12-01

Cosmologist Edward R. (Ted) Harrison, emeritus Distinguished University Professor of Physics and Astronomy at the University of Massachusetts Amherst, died on 29 January 2007 in his retirement city of Tucson, Arizona, where he was adjunct professor at the Steward Observatory, University of Arizona. The cause of death was colon cancer. He is survived by a sister, brother, and daughter. (A son died in 2000.) Perhaps best known for his work on the growth of fluctuations in the expanding universe and his books on cosmology for the dedicated layperson, Ted had extremely broad interests, and he published more than 200 papers in space sciences, plasma physics, high-energy physics, physical chemistry, and, principally, many aspects of astrophysics. He was a Fellow of the American Physical Society, the American Association for the Advancement of Science, the Royal Astronomical Society, and the Institute of Physics (UK). Ted Harrison was born 8 January 1919 in London, England. His parents were Robert Harrison and Daisy Harrison (nee White). His education at Sir John Cass College, London University, was interrupted by the Second World War, during which he served for six years with the British Army in various campaigns, ultimately acting as Radar Adviser to the Northern Area of the Egyptian Army. It was during the latter service that he met his wife Photeni (nee Marangas). Following the War, Ted became a British Civil Servant, at first with the Atomic Energy Research Establishment in Harwell and then at the Rutherford High Energy Laboratory. During this period he acquired the equivalent of university degrees, becoming a graduate, then an Associate, and finally a Fellow of the Institute of Physics. His somewhat unorthodox education may have contributed to his broad interests and his very intuitive and physical approach to scientific problems. The latter became the bane of generations of graduate students, who might find themselves asked on their physics qualifying exams to

An analysis of policy levers used to implement mental health reform in Australia 1992-2012.

Science.gov (United States)

Grace, Francesca C; Meurk, Carla S; Head, Brian W; Hall, Wayne D; Carstensen, Georgia; Harris, Meredith G; Whiteford, Harvey A

2015-10-24

Over the past two decades, mental health reform in Australia has received unprecedented government attention. This study explored how five policy levers (organisation, regulation, community education, finance and payment) were used by the Australian Federal Government to implement mental health reforms. Australian Government publications, including the four mental health plans (published in 1992, 1998, 2003 and 2008) were analysed according to policy levers used to drive reform across five priority areas: [1] human rights and community attitudes; [2] responding to community need; [3] service structures; [4] service quality and effectiveness; and [5] resources and service access. Policy levers were applied in varying ways; with two or three levers often concurrently used to implement a single initiative or strategy. For example, changes to service structures were achieved using various combinations of all five levers. Attempts to improve service quality and effectiveness were instead made through a single lever-regulation. The use of some levers changed over time, including a move away from prescriptive, legislative use of regulation, towards a greater focus on monitoring service standards and consumer outcomes. Patterns in the application of policy levers across the National Mental Health Strategy, as identified in this analysis, represent a novel way of conceptualising the history of mental health reform in Australia. An improved understanding of the strategic targeting and appropriate utilisation of policy levers may assist in the delivery and evaluation of evidence-based mental health reform in the future.

A technique for the calibration of Andrade-Chalmers cam levers used on creep tests

International Nuclear Information System (INIS)

Mendoza, A.; Salazar, A.; Morales, A.; Montemayor-Aldrete, M.

1994-01-01

In this work we report the analysis of typical errors arising from an Andrade-Chalmers lever cam, used as machine for mechanical constant stress tests. A procedure to obtain the magnitude of the applied stress as a function of the rotation of the lever arm was developed by used a mechanism which allow us to simulate the sample deformation. The used physical mechanism involves LVDT and Load Cell transducers. The characteristic parameters of the lever arm were founded using a least squares criterion procedure on the digitalized values of transducers signals. The departure existing between an actual lever and ideal one was fully analyzed. (Author) 18 refs

La Lever house, New York

Directory of Open Access Journals (Sweden)

Sergio de Miguel

2012-12-01

Full Text Available

Resumen

En el último siglo la mítica ciudad de Nueva York ha sido capaz de definir y transmitir las más contagiosas propuestas de  construcción del futuro.
El edificio de la Lever House, erigido en el corazón de Manhattan al comienzo de la prodigiosa década de los cincuenta, consiguió ser la constatación de que el perseguido sueño de la “torre de cristal” era por fin posible. La poética y secular conquista de la  levedad avanzó entonces a través de un prosaico y paradójico objeto publicitario. Un particular crisol de negocio, oportunidad y audacia hicieron de ésta sorprendente pieza un icono   fundamental de la globalizada arquitectura moderna americana.

Nota* En la edición electrónica este artículo se ha publicado con toda documentación gráfica aportada por el autor.

Palabras clave

Lever house, torre, levedad, cristal, publicidad, icono

Abstract

In the last century, the mythical city of New York has been able to define and transmit the most contagious proposals of  innovative construction.
The Lever House Building, erected in the heart of Manhattan at  the start of the prodigious 1950s managed to become a  statement for the possibility of finally realizing the sought‐after
dream of building a glass tower. The poetics and secular   conquest of lightness therefore made a leap forward through a prosaic and paradoxical publicity item. A special crucible of business, opportunity and audacity made a fundamental icon of globalized modern American Architecture out of this surprising work.

Note * In the online edition this article is published with all graphic material provided by the author.

Magic neutrino mass matrix and the Bjorken-Harrison-Scott parameterization

International Nuclear Information System (INIS)

Lam, C.S.

2006-01-01

Observed neutrino mixing can be described by a tribimaximal MNS matrix. The resulting neutrino mass matrix in the basis of a diagonal charged lepton mass matrix is both 2-3 symmetric and magic. By a magic matrix, I mean one whose row sums and column sums are all identical. I study what happens if 2-3 symmetry is broken but the magic symmetry is kept intact. In that case, the mixing matrix is parameterized by a single complex parameter U e3 , in a form discussed recently by Bjorken, Harrison, and Scott

Mechanical efficiency of two commercial lever-propulsion mechanisms for manual wheelchair locomotion.

Science.gov (United States)

Lui, Jordon; MacGillivray, Megan K; Sheel, A William; Jeyasurya, Jeswin; Sadeghi, Mahsa; Sawatzky, Bonita Jean

2013-01-01

The purpose of this study was to (1) evaluate the mechanical efficiency (ME) of two commercially available lever-propulsion mechanisms for wheelchairs and (2) compare the ME of lever propulsion with hand rim propulsion within the same wheelchair. Of the two mechanisms, one contained a torsion spring while the other used a roller clutch design. We hypothesized that the torsion spring mechanism would increase the ME of propulsion due to a passive recovery stroke enabled by the mechanism. Ten nondisabled male participants with no prior manual wheeling experience performed submaximal exercise tests using both lever-propulsion mechanisms and hand rim propulsion on two different wheelchairs. Cardiopulmonary parameters including oxygen uptake (VO2), heart rate (HR), and energy expenditure (En) were determined. Total external power (Pext) was measured using a drag test protocol. ME was determined by the ratio of Pext to En. Results indicated no significant effect of lever-propulsion mechanism for all physiological measures tested. This suggests that the torsion spring did not result in a physiological benefit compared with the roller clutch mechanism. However, both lever-propulsion mechanisms showed decreased VO2 and HR and increased ME (as a function of slope) compared with hand rim propulsion (p propulsion mechanisms tested are more mechanically efficient than conventional hand rim propulsion, especially when slopes are encountered.

49 CFR 236.340 - Electromechanical interlocking machine; locking between electrical and mechanical levers.

Science.gov (United States)

2010-10-01

... Electromechanical interlocking machine; locking between electrical and mechanical levers. In electro-mechanical interlocking machine, locking between electric and mechanical levers shall be maintained so that mechanical... 49 Transportation 4 2010-10-01 2010-10-01 false Electromechanical interlocking machine; locking...

What role does performance information play in securing improvement in healthcare? a conceptual framework for levers of change.

Science.gov (United States)

Levesque, Jean-Frederic; Sutherland, Kim

2017-08-28

Across healthcare systems, there is consensus on the need for independent and impartial assessment of performance. There is less agreement about how measurement and reporting performance improves healthcare. This paper draws on academic theories to develop a conceptual framework-one that classifies in an integrated manner the ways in which change can be leveraged by healthcare performance information. A synthesis of published frameworks. The framework identifies eight levers for change enabled by performance information, spanning internal and external drivers, and emergent and planned processes: (1) cognitive levers provide awareness and understanding; (2) mimetic levers inform about the performance of others to encourage emulation; (3) supportive levers provide facilitation, implementation tools or models of care to actively support change; (4) formative levers develop capabilities and skills through teaching, mentoring and feedback; (5) normative levers set performance against guidelines, standards, certification and accreditation processes; (6) coercive levers use policies, regulations incentives and disincentives to force change; (7) structural levers modify the physical environment or professional cultures and routines; (8) competitive levers attract patients or funders. This framework highlights how performance measurement and reporting can contribute to eight different levers for change. It provides guidance into how to align performance measurement and reporting into quality improvement programme. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Jan Lever: Challenging the Role of Typological Thinking in Reformational Views of Biology

NARCIS (Netherlands)

Cook, Harry; Flipse, A.C.

2017-01-01

This essay analyzes the view of evolution of Jan Lever (1922–2010), founder of the biology department at the Vrije Universiteit Amsterdam, and compares his view with those of J.H. Diemer and H. Dooyeweerd. Together with Dooyeweerd, Lever wrote a series of chapters on the species concept in

Extinction of Cocaine Seeking Requires a Window of Infralimbic Pyramidal Neuron Activity after Unreinforced Lever Presses.

Science.gov (United States)

Gutman, Andrea L; Nett, Kelle E; Cosme, Caitlin V; Worth, Wensday R; Gupta, Subhash C; Wemmie, John A; LaLumiere, Ryan T

2017-06-21

The infralimbic cortex (IL) mediates extinction learning and the active suppression of cocaine-seeking behavior. However, the precise temporal relationship among IL activity, lever pressing, and extinction learning is unclear. To address this issue, we used activity-guided optogenetics in male Sprague Dawley rats to silence IL pyramidal neurons optically for 20 s immediately after unreinforced lever presses during early extinction training after cocaine self-administration. Optical inhibition of the IL increased active lever pressing during shortened extinction sessions, but did not alter the retention of the extinction learning as assessed in ensuing extinction sessions with no optical inhibition. During subsequent cued reinstatement sessions, rats that had previously received optical inhibition during the extinction sessions showed increased cocaine-seeking behavior. These findings appeared to be specific to inhibition during the post-lever press period because IL inhibition given in a noncontingent, pseudorandom manner during extinction sessions did not produce the same effects. Illumination alone (i.e., with no opsin expression) and food-seeking control experiments also failed to produce the same effects. In another experiment, IL inhibition after lever presses during cued reinstatement sessions increased cocaine seeking during those sessions. Finally, inhibition of the prelimbic cortex immediately after unreinforced lever presses during shortened extinction sessions decreased lever pressing during these sessions, but had no effect on subsequent reinstatement. These results indicate that IL activity immediately after unreinforced lever presses is necessary for normal extinction of cocaine seeking, suggesting that critical encoding of the new contingencies between a lever press and a cocaine reward occurs during that period. SIGNIFICANCE STATEMENT The infralimbic cortex (IL) contributes to the extinction of cocaine-seeking behavior, but the precise relationship

Effects of orbitofrontal cortex lesions on autoshaped lever pressing and reversal learning.

Science.gov (United States)

Chang, Stephen E

2014-10-15

A cue associated with a rewarding event can trigger behavior towards the cue itself due to the cue acquiring incentive value through its pairing with the rewarding outcome (i.e., sign-tracking). For example, rats will approach, press, and attempt to "consume" a retractable lever conditioned stimulus (CS) that signals delivery of a food unconditioned stimulus (US). Attending to food-predictive CSs is important when seeking out food, and it is just as important to be able to modify one's behavior when the relationships between CSs and USs are changed. Using a discriminative autoshaping procedure with lever CSs, the present study investigated the effects of orbitofrontal cortex (OFC) lesions on sign-tracking and reversal learning. Insertion of one lever was followed by sucrose delivery upon retraction, and insertion of another lever was followed by nothing. After the acquisition phase, the contingencies between the levers and outcomes were reversed. Bilateral OFC lesions had no effect on the acquisition of sign-tracking. However, OFC-lesioned rats showed substantial deficits in acquiring sign-tracking compared to sham-lesioned rats once the stimulus-outcome contingencies were reversed. Over the course of reversal learning, OFC-lesioned rats were able to reach comparable levels of sign-tracking as sham-lesioned rats. These findings suggest that OFC is not necessary for the ability of a CS to acquire incentive value and provide more evidence that OFC is critical for modifying behavior appropriately following a change in stimulus-outcome contingencies. Copyright © 2014 Elsevier B.V. All rights reserved.

Environmental geology of Harrison Bay, northern Alaska

Science.gov (United States)

Craig, J.D.; Thrasher, G.P.

1982-01-01

The surficial and shallow subsurface geology of Harrison Bay on the Beaufort Sea coast was mapped as part of the U.S. Geological Survey's prelease evaluation for Outer Continental Shelf (OCS) Oil and Gas Lease Sale 71. During the 1980 summer season, approximately 1600 km of multisensored, high-resolution geophysical profile data were collected along a rectangular grid with 4.8 km line spacing. Interpretation of these data is presented on five maps showing bathymetry, sea-floor microrelief, ice-gouge characteristics, Holocene sediment thickness, and geologic structure to depths of approximately 1000 m. On a broad scale, the seafloor is shallow and almost flat, although microrelief features produced by sediment transport and ice-gouge processes typically vary up to several meters in amplitude. Microrelief bedforms related to hydraulic processes are predominant in water depths less than 12 m. Microrelief caused by ice gouging generally increases with water depth, reaching a maximum of 2 m or more in water depths beyond the 20 m isobath. This intensely gouged area lies beneath the shear zone between the seasonal landfast ice and the mobile polar ice pack. The thickness of recent (Holocene) sediment increases offshore, from 2 m near the Colville River delta to 30 m or more on the outer shelf. The thin Holocene layer is underlain by a complex horizon interpreted to be the upper surface of a Pleistocene deposit similar in composition to the present Arctic Coastal Plain. The base of the inferred Pleistocene section is interpreted to be a low-angle unconformity 100 m below sea level. Beneath this Tertiary-Quaternary unconformity, strata are interpreted to be alluvial fan-delta plain deposits corresponding to the Colville Group and younger formations of Late Cretaceous to Tertiary age. Numerous high-angle faults downthrown to the north trend across the survey area. With few exceptions, these faults terminate at or below the 100 m unconformity, suggesting that most tectonism

[Equivalent Lever Principle of Ossicular Chain and Amplitude Reduction Effect of Internal Ear Lymph].

Science.gov (United States)

Zhao, Xiaoyan; Qin, Renjia

2015-04-01

This paper makes persuasive demonstrations on some problems about the human ear sound transmission principle in existing physiological textbooks and reference books, and puts forward the authors' view to make up for its literature. Exerting the knowledge of lever in physics and the acoustics theory, we come up with an equivalent simplified model of manubrium mallei which is to meet the requirements as the long arm of the lever. We also set up an equivalent simplified model of ossicular chain--a combination of levers of ossicular chain. We disassemble the model into two simple levers, and make full analysis and demonstration on them. Through the calculation and comparison of displacement amplitudes in both external auditory canal air and internal ear lymph, we may draw a conclusion that the key reason, which the sound displacement amplitude is to be decreased to adapt to the endurance limit of the basement membrane, is that the density and sound speed in lymph is much higher than those in the air.

Lever conditioned stimulus-directed autoshaping induced by saccharin-ethanol unconditioned stimulus solution: effects of ethanol concentration and trial spacing.

Science.gov (United States)

Tomie, Arthur; Festa, Eugene D; Sparta, Dennis R; Pohorecky, Larissa A

2003-05-01

Two experiments were designed to evaluate whether brief access to a saccharin-ethanol solution would function as an effective unconditioned stimulus (US) in Pavlovian-autoshaping procedures. In these experiments, the insertion of a lever conditioned stimulus (CS) was followed by the brief presentation of a sipper tube containing saccharin-ethanol US solution. Experience with this Pavlovian-autoshaping procedure engendered lever CS-directed autoshaping conditioned responses (CRs) in all rats. In Experiment 1, the concentration of ethanol [0%, 2%, 4%, 6%, or 8% (vol./vol.)] in 0.1% saccharin was systematically increased within subjects across autoshaping sessions to evaluate the relation between a rat's drinking and lever pressing. In Experiment 2, the mean intertrial interval (ITI) duration (60, 90, 120 s) was systematically increased within subjects across autoshaping sessions to evaluate the effect of ITI duration on drinking and lever pressing. A pseudoconditioning control group received lever CS randomly with respect to the saccharin-ethanol US solution. In Experiment 1, lever-press autoshaping CRs developed in all rats, and the tendency of a rat to drink an ethanol concentration was predictive of the performance of lever-press autoshaping CRs. In Experiment 2, longer ITIs induced more lever CS-directed responding, and CS-US paired procedures yielded more lever CS-directed responding than that observed in CS-US random procedures. Saccharin-ethanol is an effective US in Pavlovian-autoshaping procedures, inducing more CS-directed responding than in pseudoconditioning controls receiving CS-US random procedures. More lever CS-directed responding was observed when there was more drinking of the saccharin-ethanol US solution (Experiment 1); when the CS and US were paired, rather than random (Experiment 2); and with longer mean ITI durations (Experiment 2). This pattern of results is consistent with the hypothesis that lever CS-directed responding reflects performance

Kolm tundi päevas jõusaalis ja dieet : nii voolis Harrison Ford end taas Indiana Jonesiks / Triin Tael

Index Scriptorium Estoniae

Tael, Triin

2008-01-01

Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008. Indiana Jonesi tähestik

The C-Lever Project: Haptics for Automotive Applications

NARCIS (Netherlands)

Garcia Canseco, E.; Ayemlong Fokem, A.; Serrarens, A.F.A.; Steinbuch, M.; Stigter, H.

2010-01-01

The goal of this project is to research the effectiveness of a controlled haptic force feedback shift lever that can accurately reproduce the behavior of a manual gear shift during driving, and that can also be used to control interior and comfort functions in the car.

Large Signal Circuit Model of Two-Section Gain Lever Quantum Dot Laser

International Nuclear Information System (INIS)

Horri Ashkan; Mirmoeini Seyedeh Zahra; Faez Rahim

2012-01-01

An equivalent circuit model for the design and analysis of two-section gain lever quantum dot (QD) laser is presented. This model is based on the three level rate equations with two independent carrier populations and a single longitudinal optical mode. By using the presented model, the effect of gain lever on QD laser performances is investigated. The results of simulation show that the main characteristics of laser such as threshold current, transient response, output power and modulation response are affected by differential gain ratios between the two-sections

The jaw is a second-class lever in Pedetes capensis (Rodentia: Pedetidae

Directory of Open Access Journals (Sweden)

Philip G. Cox

2017-08-01

Full Text Available The mammalian jaw is often modelled as a third-class lever for the purposes of biomechanical analyses, owing to the position of the resultant muscle force between the jaw joint and the teeth. However, it has been proposed that in some rodents the jaws operate as a second-class lever during distal molar bites, owing to the rostral position of the masticatory musculature. In particular, the infraorbital portion of the zygomatico-mandibularis (IOZM has been suggested to be of major importance in converting the masticatory system from a third-class to a second-class lever. The presence of the IOZM is diagnostic of the hystricomorph rodents, and is particularly well-developed in Pedetes capensis, the South African springhare. In this study, finite element analysis (FEA was used to assess the lever mechanics of the springhare masticatory system, and to determine the function of the IOZM. An FE model of the skull of P. capensis was constructed and loaded with all masticatory muscles, and then solved for biting at each tooth in turn. Further load cases were created in which each masticatory muscle was removed in turn. The analyses showed that the mechanical advantage of the springhare jaws was above one at all molar bites and very close to one during the premolar bite. Removing the IOZM or masseter caused a drop in mechanical advantage at all bites, but affected strain patterns and cranial deformation very little. Removing the ZM had only a small effect on mechanical advantage, but produced a substantial reduction in strain and deformation across the skull. It was concluded that the masticatory system of P. capensis acts as a second class lever during bites along almost the entire cheek tooth row. The IOZM is clearly a major contributor to this effect, but the masseter also has a part to play. The benefit of the IOZM is that it adds force without substantially contributing to strain or deformation of the skull. This may help explain why the

Sibelius: Luonnotar. Chevauchee nocturne et lever du soleil / Pierre Gervasoni

Index Scriptorium Estoniae

Gervasoni, Pierre

1996-01-01

Uuest heliplaadist "Sibelius: Luonnotar. Chevauchee nocturne et lever du soleil. 4 Legendes. Orchestre Philharmonique Royal de Stockholm, Paavo Järvi. Virgin Classics 545 213-2 (CD:167F). 1996. TT: 1h 13'22"

Coupling of lever arm swing and biased Brownian motion in actomyosin.

Directory of Open Access Journals (Sweden)

Qing-Miao Nie

2014-04-01

Full Text Available An important unresolved problem associated with actomyosin motors is the role of Brownian motion in the process of force generation. On the basis of structural observations of myosins and actins, the widely held lever-arm hypothesis has been proposed, in which proteins are assumed to show sequential structural changes among observed and hypothesized structures to exert mechanical force. An alternative hypothesis, the Brownian motion hypothesis, has been supported by single-molecule experiments and emphasizes more on the roles of fluctuating protein movement. In this study, we address the long-standing controversy between the lever-arm hypothesis and the Brownian motion hypothesis through in silico observations of an actomyosin system. We study a system composed of myosin II and actin filament by calculating free-energy landscapes of actin-myosin interactions using the molecular dynamics method and by simulating transitions among dynamically changing free-energy landscapes using the Monte Carlo method. The results obtained by this combined multi-scale calculation show that myosin with inorganic phosphate (Pi and ADP weakly binds to actin and that after releasing Pi and ADP, myosin moves along the actin filament toward the strong-binding site by exhibiting the biased Brownian motion, a behavior consistent with the observed single-molecular behavior of myosin. Conformational flexibility of loops at the actin-interface of myosin and the N-terminus of actin subunit is necessary for the distinct bias in the Brownian motion. Both the 5.5-11 nm displacement due to the biased Brownian motion and the 3-5 nm displacement due to lever-arm swing contribute to the net displacement of myosin. The calculated results further suggest that the recovery stroke of the lever arm plays an important role in enhancing the displacement of myosin through multiple cycles of ATP hydrolysis, suggesting a unified movement mechanism for various members of the myosin family.

Coupling of lever arm swing and biased Brownian motion in actomyosin.

Science.gov (United States)

Nie, Qing-Miao; Togashi, Akio; Sasaki, Takeshi N; Takano, Mitsunori; Sasai, Masaki; Terada, Tomoki P

2014-04-01

An important unresolved problem associated with actomyosin motors is the role of Brownian motion in the process of force generation. On the basis of structural observations of myosins and actins, the widely held lever-arm hypothesis has been proposed, in which proteins are assumed to show sequential structural changes among observed and hypothesized structures to exert mechanical force. An alternative hypothesis, the Brownian motion hypothesis, has been supported by single-molecule experiments and emphasizes more on the roles of fluctuating protein movement. In this study, we address the long-standing controversy between the lever-arm hypothesis and the Brownian motion hypothesis through in silico observations of an actomyosin system. We study a system composed of myosin II and actin filament by calculating free-energy landscapes of actin-myosin interactions using the molecular dynamics method and by simulating transitions among dynamically changing free-energy landscapes using the Monte Carlo method. The results obtained by this combined multi-scale calculation show that myosin with inorganic phosphate (Pi) and ADP weakly binds to actin and that after releasing Pi and ADP, myosin moves along the actin filament toward the strong-binding site by exhibiting the biased Brownian motion, a behavior consistent with the observed single-molecular behavior of myosin. Conformational flexibility of loops at the actin-interface of myosin and the N-terminus of actin subunit is necessary for the distinct bias in the Brownian motion. Both the 5.5-11 nm displacement due to the biased Brownian motion and the 3-5 nm displacement due to lever-arm swing contribute to the net displacement of myosin. The calculated results further suggest that the recovery stroke of the lever arm plays an important role in enhancing the displacement of myosin through multiple cycles of ATP hydrolysis, suggesting a unified movement mechanism for various members of the myosin family.

Oceanographic studies in Harrison Bay and the Colville River Delta, Alaska, to support the development of oil spill response strategies

International Nuclear Information System (INIS)

Owens, E.H.; Taylor, E.; Hale, B.

2003-01-01

The risk of an oil spill resulting from the development of the Alpine oil field is considered to be low. The field is located on the North Slope of Alaska adjacent to the Alaskan Beaufort Sea and reaches coastal waters from the distributary channels of the Colville River Delta. The physical environmental (hydrodynamic) conditions that would affect the transport and fate of spilled oil was investigated to further reduce the risk. During the open-water season of 2001 in Harrison Bay, near shore current meters were deployed and data on weather and surface currents was analyzed. Ocean current and wind measurements were examined to evaluate the relationship between meteorology and water levels during the open-water season. The objective was to gain a better understanding of the near shore hydrodynamic processes at play in Harrison Bay, in order to plan the most appropriate spill response strategies. The results obtained indicate that surface currents within the bay adjacent to the Colville Delta are variable. They respond to wind forces as well as other possible mechanisms like estuarine circulation. The surface currents reach maximum speeds of 0.26 metre per second. For the late July-September deployment, the calculated net surface drift was a 0.02 metre per second current to the east southeast. In both Harrison Bay and Colville Delta, prevailing southwest and northeast winds, respectively, induced water level changes of more than 0.5 metre above and below the average. 7 refs., 3 tabs., 7 figs

Study of the mechanism of clamping and detachment of a core sample by core lever lifters

Energy Technology Data Exchange (ETDEWEB)

Barabashkin, I I; Mizyakin, V M; Nikitin, S V

1981-01-01

Geometric dimensions of the basic elements of a core lifter should be determined depending on the clamping conditions. The changes should be determined depending on the conditions of the core sample diameter, critical angle between the lever and the core samples in the necessary depth of submersion of the contact edge of the lever into its surface. The core lifter KTsRZ-80 with eccentric core reception makes it possible to arrange more efficiently the core removing elements on the edge of the band. The use of the core lifters with eccentric plan of arrangement of the levers and their optimal length increases the removal of the core sample.

Rotational foot placement specifies the lever arm of the ground reaction force during the push-off phase of walking initiation.

Science.gov (United States)

Erdemir, Ahmet; Piazza, Stephen J

2002-06-01

The lever arm of the ground reaction force (GRF) about the talocrural joint axis is a functionally important indicator of the nature of foot loading. Walking initiation experiments (ten subjects; age, 23-29 years) were completed to demonstrate that rotational foot placement is a possible strategy to specify the lever arm. Externally-rotated foot placement resulted in larger lever arms during push-off. A computer simulation of push-off revealed that a decreased lever arm reduces the plantarflexion moment necessary to maintain a constant forward velocity, while increasing the required plantarflexion velocity. Shortening of the foot thus diminishes the muscular force demand but also requires high muscle fiber shortening velocities that may limit the force generating capacity of plantar flexors. Decreased plantar flexion moment and slow walking previously noted in partial-foot amputees may result from shortened lever arms in this manner.

Disconnection of basolateral amygdala and insular cortex disrupts conditioned approach in Pavlovian lever autoshaping.

Science.gov (United States)

Nasser, Helen M; Lafferty, Danielle S; Lesser, Ellen N; Bacharach, Sam Z; Calu, Donna J

2018-01-01

Previously established individual differences in appetitive approach and devaluation sensitivity observed in goal- and sign-trackers may be attributed to differences in the acquisition, modification, or use of associative information in basolateral amygdala (BLA) pathways. Here, we sought to determine the extent to which communication of associative information between BLA and anterior portions of insular cortex (IC) supports ongoing Pavlovian conditioned approach behaviors in sign- and goal-tracking rats, in the absence of manipulations to outcome value. We hypothesized that the BLA mediates goal-, but not sign- tracking approach through interactions with the IC, a brain region involved in supporting flexible behavior. We first trained rats in Pavlovian lever autoshaping to determine their sign- or goal-tracking tendency. During alternating test sessions, we gave unilateral intracranial injections of vehicle or a cocktail of gamma-aminobutyric acid (GABA) receptor agonists, baclofen and muscimol, unilaterally into the BLA and contralaterally or ipsilaterally into the IC prior to reinforced lever autoshaping sessions. Consistent with our hypothesis we found that contralateral inactivation of BLA and IC increased the latency to approach the food cup and decreased the number of food cup contacts in goal-trackers. While contralateral inactivation of BLA and IC did not affect the total number of lever contacts in sign-trackers, this manipulation increased the latency to approach the lever. Ipsilateral inactivation of BLA and IC did not impact approach behaviors in Pavlovian lever autoshaping. These findings, contrary to our hypothesis, suggest that communication between BLA and IC maintains a representation of initially learned appetitive associations that commonly support the initiation of Pavlovian conditioned approach behavior regardless of whether it is directed at the cue or the location of reward delivery. Copyright © 2017 Elsevier Inc. All rights reserved.

77 FR 9890 - Solicitation of Input From Stakeholders Regarding the Smith-Lever 3(d) Children, Youth, and...

Science.gov (United States)

2012-02-21

... DEPARTMENT OF AGRICULTURE National Institute of Food and Agriculture Solicitation of Input From Stakeholders Regarding the Smith-Lever 3(d) Children, Youth, and Families at Risk Sustainable Community... (Pub. L. 110-246) (FCEA) amended section 3(d) of the Smith-Lever Act (7 U.S.C. 343(d)) to provide the...

Levers for change: philanthropy in select South East Asian countries ...

International Development Research Centre (IDRC) Digital Library (Canada)

2016-04-29

Apr 29, 2016 ... Levers for change: philanthropy in select South East Asian countries ... the low donor awareness of societal needs and the lack of donor education and skills development. ... Tourism is an important driver of economic growth throughout Southeast Asia. ... Supporting sustainable economic growth in ASEAN.

A Lever Coupling Mechanism in Dual-Mass Micro-Gyroscopes for Improving the Shock Resistance along the Driving Direction

Directory of Open Access Journals (Sweden)

Yang Gao

2017-04-01

Full Text Available This paper presents the design and application of a lever coupling mechanism to improve the shock resistance of a dual-mass silicon micro-gyroscope with drive mode coupled along the driving direction without sacrificing the mechanical sensitivity. Firstly, the mechanical sensitivity and the shock response of the micro-gyroscope are theoretically analyzed. In the mechanical design, a novel lever coupling mechanism is proposed to change the modal order and to improve the frequency separation. The micro-gyroscope with the lever coupling mechanism optimizes the drive mode order, increasing the in-phase mode frequency to be much larger than the anti-phase one. Shock analysis results show that the micro-gyroscope structure with the designed lever coupling mechanism can notably reduce the magnitudes of the shock response and cut down the stress produced in the shock process compared with the traditional elastic coupled one. Simulations reveal that the shock resistance along the drive direction is greatly increased. Consequently, the lever coupling mechanism can change the gyroscope’s modal order and improve the frequency separation by structurally offering a higher stiffness difference ratio. The shock resistance along the driving direction is tremendously enhanced without loss of the mechanical sensitivity.

Modified compensation algorithm of lever-arm effect and flexural deformation for polar shipborne transfer alignment based on improved adaptive Kalman filter

International Nuclear Information System (INIS)

Wang, Tongda; Cheng, Jianhua; Guan, Dongxue; Kang, Yingyao; Zhang, Wei

2017-01-01

Due to the lever-arm effect and flexural deformation in the practical application of transfer alignment (TA), the TA performance is decreased. The existing polar TA algorithm only compensates a fixed lever-arm without considering the dynamic lever-arm caused by flexural deformation; traditional non-polar TA algorithms also have some limitations. Thus, the performance of existing compensation algorithms is unsatisfactory. In this paper, a modified compensation algorithm of the lever-arm effect and flexural deformation is proposed to promote the accuracy and speed of the polar TA. On the basis of a dynamic lever-arm model and a noise compensation method for flexural deformation, polar TA equations are derived in grid frames. Based on the velocity-plus-attitude matching method, the filter models of polar TA are designed. An adaptive Kalman filter (AKF) is improved to promote the robustness and accuracy of the system, and then applied to the estimation of the misalignment angles. Simulation and experiment results have demonstrated that the modified compensation algorithm based on the improved AKF for polar TA can effectively compensate the lever-arm effect and flexural deformation, and then improve the accuracy and speed of TA in the polar region. (paper)

A Learning Center on the Lever for Young Children.

Science.gov (United States)

Keislar, Evan R.; Luckenbill, Maryann

This document describes a project designed to explore the possibilities of children's learning in mechanics. The principle of the lever, one example of a simple machine, was used in the form of a balance toy. The apparatus was set up as a game in a specially devised learning center. The children made non-verbal predictions as to which way the bar…

Synthesis of lever-blade dampers with enhanced mechanical structure

Directory of Open Access Journals (Sweden)

Igor I. Sydorenko

2015-03-01

Full Text Available Since the torsion bar represents just an elastic element, the energy dissipation in suspensions problem is highly relevant for its application. Currently in quality of a dissipation device in torsion suspension are used the hydraulic dampers with movable members reciprocating translational motion respectively to the housing or lever-type hydraulic shock absorbers of piston and vane types, with the movable member’s rotational movement respectively to the housing. These dampers are implementing only throttle-valve performance type, associated with these devices’ functional capacities and depending on design constraints. The paper presents a synthesis of innovative lever-blade dampers, whose performance is not related to the value of working chambers inner pressure. Their essential peculiarity relates to the mechanical control loop presence in the structure that determines a close relationship between the performance and the value of the shock absorber movable element displacement relatively to the body. In the process of synthesis carried out tested are the appropriate methods, built on the basis of technical systems’ modeling with modified kinematic graphs. The synthesis results are shown in the form of two structurally implemented samples. Performed is a comparative analysis of the samples with their basic performance determining.

Commissioner for Inland Revenue V Lever Brothers and Unilever Ltd

African Journals Online (AJOL)

Lever Brothers, the South African tax case that formed the basis of this research, was concerned with determining the source of interest income. In its time, this was one of the landmark cases and established tax principles that were valid for 54 years, until superseded by changes to legislation. The research presented a ...

Energy efficiency: Lever for the Energy Transition

International Nuclear Information System (INIS)

2012-12-01

The Eco-electric industry group (FFIE, FGME, Gimelec, IGNES, SERCE) has conducted a study to evaluate the energy saving potential of active energy efficiency solutions in the residential and commercial building sectors. Based on field implementations and demonstrators, it has been demonstrated that active energy efficiency can sustainably achieve substantial savings for households, companies and public authorities. Energy Efficiency - Lever for the energy transition presents the results and conclusions of that study, alongside with recommendations for public authority in terms of building retrofit policy for putting France on the best possible 'trajectory' from a budgetary and environmental point of view. (author)

Commissioner for Inland Revenue v Lever Brothers and Unilever Ltd

African Journals Online (AJOL)

kirstam

21Key words: Lever Brothers and Unilever; South African income tax; source of income; interest; the “practical man”; the .... facilities, and he housed his employees in a model village of well-built homes on the factory site. ... be cancelled and any excess of the value of the shares over the debt would be adjusted by a money.

Creativity and Control : A Paradox-Evidence from the Levers of Control Framework

NARCIS (Netherlands)

Speklé, R.F.; van Elten, Hilco; Widener, Sally

2017-01-01

Both control and creativity are important drivers of organizational success (Gilson, Mathieu, Shally, and Ruddy 2005; Hirst, Van Knippenberg, Chen, and Sacramento 2011). However, they are often regarded as conflicting. We use the Levers of Control (LoC) framework to examine the relationships between

Creativity and Control : A Paradox: Evidence from the Levers of Control Framework

NARCIS (Netherlands)

Speklé, R.F.; Elten, van H.J.; Widener, S.

2017-01-01

Both control and creativity are important drivers of organizational success (Gilson, Mathieu, Shally, and Ruddy 2005; Hirst, Van Knippenberg, Chen, and Sacramento 2011). However, they are often regarded as conflicting. We use the Levers of Control (LoC) framework to examine the relationships between

Preliminary assessment report for Fort William Henry Harrison, Montana Army National Guard, Helena, Montana

International Nuclear Information System (INIS)

DuWaldt, J.; Meyer, T.

1993-07-01

This report presents the results of the preliminary assessment (PA) conducted by Argonne National Laboratory at a Montana Army National Guard (MTARNG) property near Helena, Montana. Preliminary assessments of federal facilities are being conducted to compile the information necessary for completing preremedial activities and to provide a basis for establishing corrective actions in response to releases of hazardous substances. The principal objective of the PA is to characterize the site accurately and determine the need for further action by examining site activities, quantities of hazardous substances present, and potential pathways by which contamination could affect public health and the environment. This PA satisfies, for the Fort William Henry Harrison property, requirements of the Department of Defense Installation Restoration Program

Reliable quantification of bite-force performance requires use of appropriate biting substrate and standardization of bite out-lever.

Science.gov (United States)

Lappin, A Kristopher; Jones, Marc E H

2014-12-15

Bite-force performance is an ecologically important measure of whole-organism performance that shapes dietary breadth and feeding strategies and, in some taxa, determines reproductive success. It also is a metric that is crucial to testing and evaluating biomechanical models. We reviewed nearly 100 published studies of a range of taxa that incorporate direct in vivo measurements of bite force. Problematically, methods of data collection and processing vary considerably among studies. In particular, there is little consensus on the appropriate substrate to use on the biting surface of force transducers. In addition, the bite out-lever, defined as the distance from the fulcrum (i.e. jaw joint) to the position along the jawline at which the jaws engage the transducer, is rarely taken into account. We examined the effect of bite substrate and bite out-lever on bite-force estimates in a diverse sample of lizards. Results indicate that both variables have a significant impact on the accuracy of measurements. Maximum bite force is significantly greater using leather as the biting substrate compared with a metal substrate. Less-forceful bites on metal are likely due to inhibitory feedback from mechanoreceptors that prevent damage to the feeding apparatus. Standardization of bite out-lever affected which trial produced maximum performance for a given individual. Indeed, maximum bite force is usually underestimated without standardization because it is expected to be greatest at the minimum out-lever (i.e. back of the jaws), which in studies is rarely targeted with success. We assert that future studies should use a pliable substrate, such as leather, and use appropriate standardization for bite out-lever. © 2014. Published by The Company of Biologists Ltd.

Hybrid Kalman and unscented Kalman filters for INS/GPS integrated system considering constant lever arm effect

Institute of Scientific and Technical Information of China (English)

常国宾; 柳明

2015-01-01

In inertial navigation system (INS) and global positioning system (GPS) integrated system, GPS antennas are usually not located at the same location as the inertial measurement unit (IMU) of the INS, so the lever arm effect exists, which makes the observation equation highly nonlinear. The INS/GPS integration with constant lever arm effect is studied. The position relation of IMU and GPS’s antenna is represented in the earth centered earth fixed frame, while the velocity relation of these two systems is represented in local horizontal frame. Due to the small integration time interval of INS, i.e. 0.1 s in this work, the nonlinearity in the INS error equation is trivial, so the linear INS error model is constructed and addressed by Kalman filter’s prediction step. On the other hand, the high nonlinearity in the observation equation due to lever arm effect is addressed by unscented Kalman filter’s update step to attain higher accuracy and better applicability. Simulation is designed and the performance of the hybrid filter is validated.

Characterizing piezoscanner hysteresis and creep using optical levers and a reference nanopositioning stage

International Nuclear Information System (INIS)

Xie, H.; Regnier, S.; Rakotondrabe, M.

2009-01-01

A method using atomic force microscope (AFM) optical levers and a reference nanopositioning stage has been developed to characterize piezoscanner hysteresis and creep. The piezoscanner is fixed on a closed-loop nanopositioning stage, both of which have the same arrangement on each axis of the three spatial directions inside the AFM-based nanomanipulation system. In order to achieve characterization, the optical lever is used as a displacement sensor to measure the relative movement between the nanopositioning stage and the piezoscanner by lateral tracking a well-defined slope with the tapping mode of the AFM cantilever. This setup can be used to estimate a piezoscanner's voltage input with a reference displacement from the nanopositioning stage. The hysteresis and creep were accurately calibrated by the method presented, which use the current setup of the AFM-based nanomanipulation system without any modification or additional devices.

Symmetry Analysis of Gauge-Invariant Field Equations via a Generalized Harrison-Estabrook Formalism.

Science.gov (United States)

Papachristou, Costas J.

The Harrison-Estabrook formalism for the study of invariance groups of partial differential equations is generalized and extended to equations that define, through their solutions, sections on vector bundles of various kinds. Applications include the Dirac, Yang-Mills, and self-dual Yang-Mills (SDYM) equations. The latter case exhibits interesting connections between the internal symmetries of SDYM and the existence of integrability characteristics such as a linear ("inverse scattering") system and Backlund transformations (BT's). By "verticalizing" the generators of coordinate point transformations of SDYM, nine nonlocal, generalized (as opposed to local, point) symmetries are constructed. The observation is made that the prolongations of these symmetries are parametric BT's for SDYM. It is thus concluded that the entire point group of SDYM contributes, upon verticalization, BT's to the system.

Great expectations: patient choice as a lever for change in health care.

NARCIS (Netherlands)

Friele, R.D.

2011-01-01

The introduction of market forces in the Dutch health care system is partially based on assumptions regarding patients' behavior. They are expected to actively choose their care providers. Their choices may work as a lever for change. When asked, most patients say that they find it very important to

Equality versus Freedom in ‘‘Harrison Bergeron” by Kurt Vonnegut: A Study of Dystopian Setting

Directory of Open Access Journals (Sweden)

Abdol Hossein Joodaki

2013-05-01

Full Text Available This article is devoted to the analysis of one of Kurt Vonnegut’s dystopian short stories, Harrison Bergeron, through the setting analysis  focusing mainly on the use of media as a means of creating mono logical setting and discussing the dance scene as an act of escape from this mono logical setting. Kurt Vonnegut, a contemporary American novelist and short story writer, using his experiences during World War II, reflects on the post war American society especially through his satirical works about power structures. And in this short story he satirizes the forced equality in an imaginary American society.

Electron microscopic evidence for the myosin head lever arm mechanism in hydrated myosin filaments using the gas environmental chamber

International Nuclear Information System (INIS)

Minoda, Hiroki; Okabe, Tatsuhiro; Inayoshi, Yuhri; Miyakawa, Takuya; Miyauchi, Yumiko; Tanokura, Masaru; Katayama, Eisaku; Wakabayashi, Takeyuki; Akimoto, Tsuyoshi; Sugi, Haruo

2011-01-01

Research highlights: → We succeeded in recording structural changes of hydrated myosin cross-bridges. → We succeeded in position-marking the cross-bridges with site-directed antibodies. → We recorded cross-bridge movement at different regions in individual cross-bridge. → The movement was smallest at the cross-bridge-subfragment two boundary. → The results provide evidence for the cross-bridge lever arm mechanism. -- Abstract: Muscle contraction results from an attachment-detachment cycle between the myosin heads extending from myosin filaments and the sites on actin filaments. The myosin head first attaches to actin together with the products of ATP hydrolysis, performs a power stroke associated with release of hydrolysis products, and detaches from actin upon binding with new ATP. The detached myosin head then hydrolyses ATP, and performs a recovery stroke to restore its initial position. The strokes have been suggested to result from rotation of the lever arm domain around the converter domain, while the catalytic domain remains rigid. To ascertain the validity of the lever arm hypothesis in muscle, we recorded ATP-induced movement at different regions within individual myosin heads in hydrated myosin filaments, using the gas environmental chamber attached to the electron microscope. The myosin head were position-marked with gold particles using three different site-directed antibodies. The amplitude of ATP-induced movement at the actin binding site in the catalytic domain was similar to that at the boundary between the catalytic and converter domains, but was definitely larger than that at the regulatory light chain in the lever arm domain. These results are consistent with the myosin head lever arm mechanism in muscle contraction if some assumptions are made.

Implementing a university e-learning strategy: levers for change within academic schools

Directory of Open Access Journals (Sweden)

Rhona Sharpe

2006-12-01

Full Text Available This paper describes the implementation of an e-learning strategy at a single higher education institution in terms of the levers used to promote effective uptake and ensure sustainable embedding. The focus of this work was at the level of the academic school using a range of change practices including the appointment of school-based learning technologists and e-learning champions, supporting schools to write their own strategies, a pedagogical framework of engaging with e-learning, and curriculum development and evaluation of school-supported projects. It is clear that the implementation of the e-learning strategy has led to a large and increasing proportion of our students experiencing blended learning. In addition, there are initial indications that this has enhanced some learning and teaching processes. Where there has been sustainable embedding of effective e-learning, the following levers were identified as particularly important: flexibility in practices that allow schools to contextualise their plans for change, the facilitation of communities of key staff and creating opportunities for staff to voice and challenge their beliefs about e-learning.

Investigation of thermodynamic and transport properties of liquid transition metals using Wills-Harrison potentials

International Nuclear Information System (INIS)

Khaleque, M.A.; Bhuiyan, G.M.; Rashid, R.I.M.A.

1998-01-01

Thermodynamic properties such as entropy, specific heat capacity at constant pressure and isothermal compressibility have been calculated for liquid 3d, 4d and 5d transition metals near melting temperature. The hard sphere diameter for all such systems is estimated from the potential profile generated from the Wills and Harrison's prescription using linearized WCA theory of liquid. Evaluated values of entropy and specific heat capacity are found to be in good agreement with the experimental data. Transport property like shear viscosity for these liquid metals is obtained using the same potential profile. Lack of experimental data at melting temperatures hampers detailed comparison for all such systems. However, for the case of transport property, the results obtained are found to compare qualitatively well with the available experimental data. (author)

Improper positioning of the elevator lever of duodenoscopes may lead to sequestered bacteria that survive disinfection by automated endoscope reprocessors.

Science.gov (United States)

Alfa, Michelle J; Singh, Harminder; Duerksen, Donald R; Schultz, Gale; Reidy, Carol; DeGagne, Pat; Olson, Nancy

2018-01-01

Some outbreaks associated with contaminated duodenoscopes have been attributed to biofilm formation. The objective of this study was to determine whether bacteria within an organic matrix could survive if the elevator lever was improperly positioned in the automated endoscope reprocessor (AER) after 1 round of reprocessing. Duodenoscope lever cavities with an open or sealed elevator wire channel were inoculated with 6-7 Log 10 of both Escherichia coli and Enterococcus faecalis in ATS2015 (Healthmark Industries, Fraser, MI) and dried for 2 hours. The duodenoscopes with the lever in the horizontal position were processed through 2 makes of AERs. The cavity was sampled using a flush-brush-flush method to determine the quantity of surviving bacteria. E faecalis (range, 21-6 Log 10 CFU) and E coli (range, 0-3 Log 10 CFU) survived disinfection of sealed or unsealed elevator wire channel duodenoscopes in 2 different AERs with and without cleaning cycles. If bacteria in organic residue are under the improperly positioned lever, then just 1 round of use is sufficient for bacteria to survive both liquid chemical sterilization and liquid chemical HLD regardless of whether or not the AER had a cleaning cycle. Copyright © 2018 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Impurity doping effects on the orbital thermodynamic properties of hydrogenated graphene, graphane, in Harrison model

Science.gov (United States)

Yarmohammadi, Mohsen

2016-12-01

Using the Harrison model and Green's function technique, impurity doping effects on the orbital density of states (DOS), electronic heat capacity (EHC) and magnetic susceptibility (MS) of a monolayer hydrogenated graphene, chair-like graphane, are investigated. The effect of scattering between electrons and dilute charged impurities is discussed in terms of the self-consistent Born approximation. Our results show that the graphane is a semiconductor and its band gap decreases with impurity. As a remarkable point, comparatively EHC reaches almost linearly to Schottky anomaly and does not change at low temperatures in the presence of impurity. Generally, EHC and MS increases with impurity doping. Surprisingly, impurity doping only affects the salient behavior of py orbital contribution of carbon atoms due to the symmetry breaking.

Effect of cantilever geometry on the optical lever sensitivities and thermal noise method of the atomic force microscope.

Science.gov (United States)

Sader, John E; Lu, Jianing; Mulvaney, Paul

2014-11-01

Calibration of the optical lever sensitivities of atomic force microscope (AFM) cantilevers is especially important for determining the force in AFM measurements. These sensitivities depend critically on the cantilever mode used and are known to differ for static and dynamic measurements. Here, we calculate the ratio of the dynamic and static sensitivities for several common AFM cantilevers, whose shapes vary considerably, and experimentally verify these results. The dynamic-to-static optical lever sensitivity ratio is found to range from 1.09 to 1.41 for the cantilevers studied - in stark contrast to the constant value of 1.09 used widely in current calibration studies. This analysis shows that accuracy of the thermal noise method for the static spring constant is strongly dependent on cantilever geometry - neglect of these dynamic-to-static factors can induce errors exceeding 100%. We also discuss a simple experimental approach to non-invasively and simultaneously determine the dynamic and static spring constants and optical lever sensitivities of cantilevers of arbitrary shape, which is applicable to all AFM platforms that have the thermal noise method for spring constant calibration.

Effects of muscimol, amphetamine, and DAMGO injected into the nucleus accumbens shell on food-reinforced lever pressing by undeprived rats.

Science.gov (United States)

Stratford, Thomas R; Wirtshafter, David

2012-05-01

Previous studies have shown that large increases in food intake in nondeprived animals can be induced by injections of both the GABA(A) agonist muscimol and the μ-opioid agonist DAMGO into the nucleus accumbens shell (AcbSh), while injections of the catecholamine agonist amphetamine have little effect. In the current study we examined whether injections of these drugs are able to increase food-reinforced lever pressing in nondeprived rats. Twelve subjects were trained to lever press on a continuous reinforcement schedule while food deprived and were then tested after being placed back on ad libitum feeding. Under these conditions, responding was markedly increased by injections of either muscimol or DAMGO, although the onset of the effects of the latter drug was delayed by 30-40 min. In contrast, amphetamine injections failed to increase reinforced lever pressing, although they did enhance responding on a non-reinforced lever, presumably reflecting alterations in behavioral activation. These results demonstrate that stimulation of GABA(A) and μ-opioid receptors within the AcbSh is able to promote not only food intake, but also food-directed operant behavior. In contrast, stimulation of AcbSh dopamine receptors may enhance behavioral arousal, but does not appear to specifically potentiate behaviors directed toward food procurement. Copyright © 2012 Elsevier Inc. All rights reserved.

Probing muscle myosin motor action: x-ray (m3 and m6) interference measurements report motor domain not lever arm movement.

Science.gov (United States)

Knupp, Carlo; Offer, Gerald; Ranatunga, K W; Squire, John M

2009-07-10

The key question in understanding how force and movement are produced in muscle concerns the nature of the cyclic interaction of myosin molecules with actin filaments. The lever arm of the globular head of each myosin molecule is thought in some way to swing axially on the actin-attached motor domain, thus propelling the actin filament past the myosin filament. Recent X-ray diffraction studies of vertebrate muscle, especially those involving the analysis of interference effects between myosin head arrays in the two halves of the thick filaments, have been claimed to prove that the lever arm moves at the same time as the sliding of actin and myosin filaments in response to muscle length or force steps. It was suggested that the sliding of myosin and actin filaments, the level of force produced and the lever arm angle are all directly coupled and that other models of lever arm movement will not fit the X-ray data. Here, we show that, in addition to interference across the A-band, which must be occurring, the observed meridional M3 and M6 X-ray intensity changes can all be explained very well by the changing diffraction effects during filament sliding caused by heads stereospecifically attached to actin moving axially relative to a population of detached or non-stereospecifically attached heads that remain fixed in position relative to the myosin filament backbone. Crucially, and contrary to previous interpretations, the X-ray interference results provide little direct information about the position of the myosin head lever arm; they are, in fact, reporting relative motor domain movements. The implications of the new interpretation are briefly assessed.

Time Restored - The Harrison Timekeepers and R.T. Gould, the Man Who Knew (Almost) Everything

Science.gov (United States)

Betts, Jonathan

2006-09-01

This is the story of Rupert T. Gould (1890-1948), the polymath and horologist. A remarkable man, Lt Cmdr Gould made important contributions in an extraordinary range of subject areas throughout his relatively short and dramatically troubled life. From antique clocks to scientific mysteries, from typewriters to the first systematic study of the Loch Ness Monster, Gould studied and published on them all. With the title The Stargazer, Gould was an early broadcaster on the BBC's Children's Hour when, with his encyclopaedic knowledge, he became known as The Man Who Knew Everything. Not surprisingly, he was also part of that elite group on BBC radio who formed The Brains Trust, giving on-the-spot answers to all manner of wide ranging and difficult questions. With his wide learning and photographic memory, Gould awed a national audience, becoming one of the era's radio celebrities. During the 1920s Gould restored the complex and highly significant marine timekeepers constructed by John Harrison (1693-1776), and wrote the unsurpassed classic, The Marine Chronometer, its History and Development . Today he is virtually unknown, his horological contributions scarcely mentioned in Dava Sobel's bestseller Longitude. The TV version of Longitude, in which Jeremy Irons played Rupert Gould, did at least introduce Gould's name to a wider public. Gould suffered terrible bouts of depression, resulting in a number of nervous breakdowns. These, coupled with his obsessive and pedantic nature, led to a scandalously-reported separation from his wife and cost him his family, his home, his job, and his closest friends. In this first-ever biography of Rupert Gould, Jonathan Betts, the Royal Observatory Greenwich's Senior Horologist, has given us a compelling account of a talented but flawed individual. Using hitherto unknown personal journals, the family's extensive collection of photographs, and the polymath's surviving records and notes, Betts tells the story of how Gould's early life, his

A 3-lever discrimination procedure reveals differences in the subjective effects of low and high doses of MDMA.

Science.gov (United States)

Harper, David N; Langen, Anna-Lena; Schenk, Susan

2014-01-01

Drug discrimination studies have suggested that the subjective effects of low doses of (±)3,4-methylenedioxymethamphetamine (MDMA) are readily differentiated from those of d-amphetamine (AMPH) and that the discriminative stimulus properties are mediated by serotonergic and dopaminergic mechanisms, respectively. Previous studies, however, have primarily examined responses to doses that do not produce substantial increases in extracellular dopamine. The present study determined whether doses of MDMA that produce increases in synaptic dopamine would also produce subjective effects that were more like AMPH and were sensitive to pharmacological manipulation of D1-like receptors. A three-lever drug discrimination paradigm was used. Rats were trained to respond on different levers following saline, AMPH (0.5mg/kg, IP) or MDMA (1.5mg/kg, IP) injections. Generalization curves were generated for a range of different doses of both drugs and the effect of the D1-like antagonist, SCH23390 on the discriminative stimulus effects of different doses of MDMA was determined. Rats accurately discriminated MDMA, AMPH and saline. Low doses of MDMA produced almost exclusive responding on the MDMA lever but at doses of 3.0mg/kg MDMA or higher, responding shifted to the AMPH lever. The AMPH response produced by higher doses of MDMA was attenuated by pretreatment with SCH23390. The data suggest that low doses and higher doses of MDMA produce distinct discriminative stimuli. The shift to AMPH-like responding following administration of higher doses of MDMA, and the decrease in this response following administration of SCH23390 suggests a dopaminergic component to the subjective experience of MDMA at higher doses. Copyright © 2013 Elsevier Inc. All rights reserved.

Individual differences in pavlovian autoshaping of lever pressing in rats predict stress-induced corticosterone release and mesolimbic levels of monoamines.

Science.gov (United States)

Tomie, A; Aguado, A S; Pohorecky, L A; Benjamin, D

2000-03-01

Pavlovian autoshaping CRs are directed and reflexive consummatory responses targeted at objects repeatedly paired with rewarding substances. To evaluate the hypothesis that autoshaping may provide an animal learning model of vulnerability to drug abuse, this study relates individual differences in lever-press autoshaping CR performance in rats to stress-induced corticosterone release and tissue monoamine levels in the mesolimbic dopamine tract. Long-Evans rats (n = 14) were given 20 sessions of Pavlovian autoshaping training wherein the insertion of a retractable lever CS was followed by the response-independent presentation of food US. Large between-subjects differences in lever-press autoshaping CR performance were observed, with group high CR frequency (n = 5) performing many more lever press CRs than group low CR frequency (n = 9). Tail-blood samples were obtained before and after the 20th autoshaping session, then 24 h later the rats were sacrificed and dissection yielded tissue samples of nucleus accumbens (NAC), prefrontal cortex (PFC), caudate putamen (CP), and ventral tegmental area (VTA). Serum levels of postsession corticosterone were elevated in group high CR frequency. HPLC revealed that group high CR frequency had higher tissue levels of dopamine and DOPAC in NAC, lower levels of DOPAC/DA turnover in CP, and lower levels of 5-HIAA and lower 5-HIAA/5-HT turnover in VTA. The neurochemical profile of rats that perform more autoshaping CRs share some features of vulnerability to drug abuse.

Clara Harrison Town and the origins of the first institutional commitment law for the "feebleminded": psychologists as expert diagnosticians.

Science.gov (United States)

Farreras, Ingrid G

2014-11-01

The first law providing for the commitment of "feeble-minded" individuals in the United States was passed in 1915, in the state of Illinois. House Bill 655 not only allowed for the permanent, involuntary institutionalization of feeble-minded individuals, but it shifted the commitment and discharge authority from the institution superintendents to the courts. Clara Harrison Town, a student of Lightner Witmer, and the state psychologist at the second largest institution for feeble-minded individuals in the country, was instrumental in this law passing and in ensuring that psychologists, for the first time, be viewed as court "experts" when testifying as to the feeble mindedness of individuals.

NRC Information Notice No. 93-22: Tripping of Klockner-Moeller molded-case circuit breakers due to support lever failure

International Nuclear Information System (INIS)

Grimes, B.K.

1993-01-01

On July 1, 1992, Virginia Electric and Power Company (VEPCO), licensee for North Anna Power Station (North Anna), Units 1 and 2, reported to the NRC that over a three-month period in 1992, three K-M model NZM6-63, 480-Vac MCCBs had tripped without appreciable load or fault condition or other electrical or mechanical transient. The three failed MCCBs were located in the cable vault and tunnel area of North Anna-2 and supplied power to motor operated valves in the charging and safety injection systems. The switch handles were found in the trip-free position and the breakers could not be relatched and reclosed. Examination of the internals of one of the three failed breakers revealed that its support lever (also described by VEPCO as a ''spring arm''), located in the rear compartment of the case, had fractured. This caused the breaker to trip and to become incapable of being reclosed. The NRC has determined that the support levers only in K-M model NZM6, NZM6b, and NZMH6 MCCBs, rated for 100 amperes and below and manufactured from 1972 on, have been made of the same type of plastic used in the support levers of the MCCBs that failed at North Anna-2

Obituary: Harrison Edward Radford, 1927-2000

Science.gov (United States)

Moran, James Michael; Kirby, Kate Page; Chance, Kelly V.; Brown, Campbell

2003-12-01

Harrison Edward ``Harry" Radford, a noted laboratory spectroscopist and pioneer in the application of magnetic resonance techniques to spectroscopy, died on 5 May 2000, after a long battle with amyotropic lateral sclerosis (ALS). During a 37-year career at the National Bureau of Standards and the Smithsonian Astrophysical Observatory, Harry measured the frequencies of numerous molecular transitions which aided the emerging field of astrochemistry. Harry was both an excellent theoretician and a preeminently skilled experimentalist. He has several major spectroscopic achievements to his credit. He performed the first study of a short-lived molecular free radical, OH, by electron paramagnetic resonance spectroscopy, opening up a huge and important field of research. Together with colleagues he made the first observation of the rotational spectrum of CH by far infrared laser magnetic resonance spectroscopy and extended the technique to other molecules such as CH3O. Harry was born in Peterborough, New Hampshire, on 26 July 1927. He was the son of Harrison Edwin Radford, a roofer, and Dorothy (née Cole) Radford. He dropped out of high school to join the Navy in 1944 as an electronics technician's mate. After his discharge in 1946 he worked in the family construction business for four years as a roofer. In 1950 he entered the University of New Hampshire and graduated four years later, Summa Cum Laude, with a degree in physics. As a graduate student at Yale from 1954 to 1959 he wrote his PhD thesis under the supervision of V.W. Hughes on the microwave Zeeman spectra of oxygen and fluorine where he used the technique of paramagnetic resonance absorption in atomic vapors. In 1954 he married Mildred Spofford. They had three daughters, Susan (born in 1955), Amy (1957), and Sarah (1960). In 1974 he married Alfa Goldthwaithe Morrison, who survived him. From 1959 until 1969 Harry worked at the National Bureau of Standards (now the National Institute of Standards and Technology

IE Information Notice No. 85-93: Westinghouse Type DS circuit breakers, potential failure of electric closing feature because of broken spring release latch lever

International Nuclear Information System (INIS)

Jordan, E.L.

1992-01-01

On April 14, 1985, the Westinghouse Nuclear Services Integration Division (NSID) issued Technical Bulletin No. NSID-TB-85-17 advising their customers of a potential malfunction in Westinghouse Type DS Class 1E circuit breakers because of broken spring release latch levers. These electrically operated type DS breakers will not close electrically when the spring release latch lever has been broken off. Twenty-five broken levers have been reported and evaluated. This evaluation shows concentrations of incidents traceable to manufacturing in the following periods of time: early 1975, April 1976, and early 1978. This circuit breaker failure, as discussed, adversely affects the safety function (closing on demand) when the circuit breaker is used in the Engineered Safety Features Systems. However, this failure mode will not affect the safety trip function when it is used in the reactor protection system

Parrotfish grazing ability: interspecific differences in relation to jaw-lever mechanics and relative weight of adductor mandibulae on an Okinawan coral reef

Directory of Open Access Journals (Sweden)

Atsushi Nanami

2016-09-01

Full Text Available Parrotfishes (family Labridae: Scarini are regarded to have important roles for maintaining the ecosystem balance in coral reefs due to their removal of organic matter and calcic substrates by grazing. The purpose of the present study was to clarify the interspecific differences in grazing ability of five parrotfish species (Chlorurus sordidus, C. bowersi, Scarus rivulatus, S. niger and S. forsteni in relation to interspecific differences in jaw-lever mechanics and the relative weight of the adductor mandibulae (muscles operating jaw closing. The grazing ability was calculated by using stomach contents (CaCO3 weight/organic matter weight defined as the grazing ability index (GAI. There were significant interspecific differences in GAI (C. sordidus = C. bowersi > S. rivulatus > S. niger = S. forsteni. Teeth of C. sordidus and C. bowersi were protrusive-shape whereas teeth of S. rivulatus, S. niger and S. forsteni were flat-shape. C. sordidus and C. bowersihave jaw-lever mechanics producing a greater biting force and have a larger weight of adductor mandibulae. S. rivulatus has jaw-lever mechanics producing a greater biting force but a smaller weight of adductor mandibulae that produce an intermediate biting force. In contrast, S. niger and S. forsteni have jaw-lever mechanics producing a lesser biting force and have a smaller weight of adductor mandibulae. Feeding rates and foray size of S. rivulatus, S. niger and S. forsteni were greater than C. sordidus and C. bowersi. The degree in bioerosion (GAI × feeding rate was the largest for S. rivulatusand the smallest for S. forsteni. The degree in bioerosion for C. sordidus was larger than S. niger whereas relatively equal between C. bowersi and S. niger. These results suggest that interspecific difference in GAI was explained by interspecific differences in teeth shape, jaw-lever mechanics and relative weight of adductor mandibulae. The interspecific difference in the degree of bioerosion suggests

Parrotfish grazing ability: interspecific differences in relation to jaw-lever mechanics and relative weight of adductor mandibulae on an Okinawan coral reef.

Science.gov (United States)

Nanami, Atsushi

2016-01-01

Parrotfishes (family Labridae: Scarini) are regarded to have important roles for maintaining the ecosystem balance in coral reefs due to their removal of organic matter and calcic substrates by grazing. The purpose of the present study was to clarify the interspecific differences in grazing ability of five parrotfish species (Chlorurus sordidus, C. bowersi, Scarus rivulatus, S. niger and S. forsteni) in relation to interspecific differences in jaw-lever mechanics and the relative weight of the adductor mandibulae (muscles operating jaw closing). The grazing ability was calculated by using stomach contents (CaCO3 weight/organic matter weight) defined as the grazing ability index (GAI). There were significant interspecific differences in GAI (C. sordidus = C. bowersi > S. rivulatus > S. niger = S. forsteni). Teeth of C. sordidus and C. bowersi were protrusive-shape whereas teeth of S. rivulatus, S. niger and S. forsteni were flat-shape. C. sordidus and C. bowersihave jaw-lever mechanics producing a greater biting force and have a larger weight of adductor mandibulae. S. rivulatus has jaw-lever mechanics producing a greater biting force but a smaller weight of adductor mandibulae that produce an intermediate biting force. In contrast, S. niger and S. forsteni have jaw-lever mechanics producing a lesser biting force and have a smaller weight of adductor mandibulae. Feeding rates and foray size of S. rivulatus, S. niger and S. forsteni were greater than C. sordidus and C. bowersi. The degree in bioerosion (GAI × feeding rate) was the largest for S. rivulatusand the smallest for S. forsteni. The degree in bioerosion for C. sordidus was larger than S. niger whereas relatively equal between C. bowersi and S. niger. These results suggest that interspecific difference in GAI was explained by interspecific differences in teeth shape, jaw-lever mechanics and relative weight of adductor mandibulae. The interspecific difference in the degree of bioerosion suggests the

Deviations of the lepton mapping matrix form the harrison-perkins-scott form

International Nuclear Information System (INIS)

Friedberg, R.; Lee, T.D.

2010-01-01

We propose a simple set of hypotheses governing the deviations of the leptonic mapping matrix from the Harrison-Perkins-Scott (HPS) form. These deviations are supposed to arise entirely from a perturbation of the mass matrix in the charged lepton sector. The perturbing matrix is assumed to be purely imaginary (thus maximally T-violating) and to have a strength in energy scale no greater (but perhaps smaller) than the muon mass. As we shall show,it then follows that the absolute value of the mapping matrix elements pertaining to the tau lepton deviate by no more than O((m μ /m τ ) 2 ) ≅ 3.5 x 10 -3 from their HPS values. Assuming that(m μ /m τ ) 2 can be neglected, we derive two simple constraints on the four parameters θ12, θ23, θ31, and δ of the mapping matrix. These constraints are independent of the details of the imaginary T-violating perturbation of the charged lepton mass matrix. We also show that the e and μ parts of the mapping matrix have a definite form governed by two parameters α and β; any deviation of order m μ /m τ can be accommodated by adjusting these two parameters. (authors)

Diseño de mecanismos de palancas asistido por computadora. // Computer Aided Design of lever mechanisms.

Directory of Open Access Journals (Sweden)

J. L. Betancourt Herrera

2001-07-01

Full Text Available En la práctica del diseño industrial hay múltiples problemas que requieren de la creación de un mecanismo concaracterísticas de movimiento peculiares. La elección de un método que permita la síntesis estructural, el planteamiento ysolución de las ecuaciones correspondientes, requeridas para el análisis cinemático de los mecanismos de palancas, en unaforma clara y simple, es un problema muy complejo de resolver en sentido general.Tomando como referencia la teoría para la formación de los grupos de Assur, el autor desarrolló el método de los gruposestructurales y sobre esta base el software DSM (Diseño y Simulación de Mecanismos, que es la herramienta de cómputopropuesta para apoyar al diseñador en el proceso de Diseño Cualitativo de Mecanismos de Palancas Asistido porComputadora, que consiste en un proceso iterativo entre síntesis y análisis con el que se pueden obtener los resultados de lavariación de la estructura de un mecanismo y de sus parámetros fundamentales, prácticamente en tiempo real.En el presente trabajo se definen y ejemplifican los conceptos y elementos principales relacionados con el diseñocualitativo de mecanismos de palancas asistido por computadora.Palabras claves: CAD, mecanismos de palancas, diseño industrial, análisis cinemático, síntesis estructural.___________________________________________________________________________AbstractThere are series of problems in industrial design practice that require a mechanism with specific characteristic movement.Selecting a method for achieving a clear and simple structural synthesis and cinematic analysis of lever mechanisms isgenerally understood as a hard-solving problem. Based on Assur´s Group Forming Theory, the author developed theStructural Groups Method and the DSM software (Design and Simulation of Mechanisms. This software is a tool intendedto help designers in the process of Computer Assisted Qualitative Design of Lever Mechanisms. It consists

Wave Energy, Lever Operated Pivoting Float LOPF Study

DEFF Research Database (Denmark)

Margheritini, Lucia

The fully instrumented Resen Waves Lever Operated Pivoting Float LOPF wave energy buoy model has gone through the first stage of testing in regular waves in scale 1:25 of the North Sea wave conditions, in the 3D deep wave basin at the Hydraulic and Coastal Engineering Laboratory of Aalborg...... University in Denmark. The model size was 60cm W x 90cm L x 21cm H. The 60 cm width pointed towards the wave front. The LOPF buoy is characterized by a simple mechanical design with few moving parts and direct electrical output and it is taut moored to the sea bed, so all forces are referenced to the seabed...... for maximum energy output in regular as well as irregular waves. During storms the buoy pivots and streamlines itself to minimize loads on the mooring line. A conservative estimate shows that a full scale system for North Sea conditions has a float size width of 15 m that will, with 60% generator efficiency...

Sterile Reverse Osmosis Water Combined with Friction Are Optimal for Channel and Lever Cavity Sample Collection of Flexible Duodenoscopes

Directory of Open Access Journals (Sweden)

Michelle J. Alfa

2017-11-01

Full Text Available IntroductionSimulated-use buildup biofilm (BBF model was used to assess various extraction fluids and friction methods to determine the optimal sample collection method for polytetrafluorethylene channels. In addition, simulated-use testing was performed for the channel and lever cavity of duodenoscopes.Materials and methodsBBF was formed in polytetrafluorethylene channels using Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa. Sterile reverse osmosis (RO water, and phosphate-buffered saline with and without Tween80 as well as two neutralizing broths (Letheen and Dey–Engley were each assessed with and without friction. Neutralizer was added immediately after sample collection and samples concentrated using centrifugation. Simulated-use testing was done using TJF-Q180V and JF-140F Olympus duodenoscopes.ResultsDespite variability in the bacterial CFU in the BBF model, none of the extraction fluids tested were significantly better than RO. Borescope examination showed far less residual material when friction was part of the extraction protocol. The RO for flush-brush-flush (FBF extraction provided significantly better recovery of E. coli (p = 0.02 from duodenoscope lever cavities compared to the CDC flush method.Discussion and conclusionWe recommend RO with friction for FBF extraction of the channel and lever cavity of duodenoscopes. Neutralizer and sample concentration optimize recovery of viable bacteria on culture.

Energy integration: Regional economic integration lever and possible insertion factor in the global economy

International Nuclear Information System (INIS)

Lokolo, M.C.

2001-01-01

In the 1920s, just after the War, an idea began taking root in the Old Continent, to build what could be described as the United States of Europe. Thirty years later, in 1951, a new source of energy, coal, paved the way for the economic integration of Europe. It culminated into monetary integration in January 2002. Economic integration makes sense in the context of the relatively small size of some national economies and markets, and the judicious utilization of rare resources and their unequal distribution. In this document, the author elaborated on the principles at play in economic integration and argued that the integration of the national energy markets could be the lever for economic integration through the gradual elimination of the various obstacles to trade. The author first presented a brief historical overview of economic integration from the perspective of global economic relationships, covering the period between the two world wars to the General Agreement on Tariffs and Trade (GATT) to the World Trade Organization (WTO). The concept and the forms of economic integration were reviewed. Energy integration as a lever of regional economic integration and as a factor in global economic insertion were discussed. Energy integration is a tool for the improvement of the human condition. 15 refs

The Role of Control System in Increasing Corporate social Performance: The Use of Levers of Control

Directory of Open Access Journals (Sweden)

Hasan Fauzi

2008-06-01

Full Text Available One important instrument to be used in the control system design is strategic behaviors that can lead to the expected organization performance.  Referring to the extended definition of strategic behavior using stakeholder-based strategic behavior, corporate social performance is kind of strategic behavior to be influenced by using control system. This paper discusses how control system, using Simons‟ levers of control can play important role in increasing the corporate social performance. The interaction between control system, including belief system, boundary system, diagnostic control system, and interactive control system, as well as the corporate financial performance (CFP can affect the corporate social performance (CSP due to fact that increase in CFP resulting from the appropriate use of control system components enables the company has more chance to do the CSP. The levers of control are deemed to form an integral part of employee socialization and support the development of an organization‟s culture, the system of shared beliefs, values, norms, and mores of organizational members which are deemed to be a primary determinant of the direction of employee behavior.

Economic Levers for Mitigating Interest Flooding Attack in Named Data Networking

Directory of Open Access Journals (Sweden)

Licheng Wang

2017-01-01

Full Text Available As a kind of unwelcome, unavoidable, and malicious behavior, distributed denial of service (DDoS is an ongoing issue in today’s Internet as well as in some newly conceived future Internet architectures. Recently, a first step was made towards assessing DDoS attacks in Named Data Networking (NDN—one of the promising Internet architectures in the upcoming big data era. Among them, interest flooding attack (IFA becomes one of the main serious problems. Enlightened by the extensive study on the possibility of mitigating DDoS in today’s Internet by employing micropayments, in this paper we address the possibility of introducing economic levers, say, dynamic pricing mechanism, and so forth, for regulating IFA in NDN.

Experimental and Theoretical Investigations of a Mechanical Lever System Driven by a DC Motor

Science.gov (United States)

Nana, B.; Fautso Kuiate, G.; Yamgoué, S. B.

This paper presents theoretical and experimental results on the investigation of the dynamics of a nonlinear electromechanical system made of a lever arm actuated by a DC motor and controlled through a repulsive magnetic force. We use the method of harmonic balance to derive oscillatory solutions. Theoretical tools such as, bifurcation diagrams, Lyapunov exponents, phase portraits, are used to unveil the rich nonlinear behavior of the system including chaos and hysteresis. The experimental results are in close accordance with the theoretical predictions.

Fabrication of tungsten tip for scanning tunneling microscope by the lever principle

International Nuclear Information System (INIS)

Wang Yang; Wang Huabin; Chinese Academy of Sciences, Beijing; Gong Jinlong; Zhu Dezhang

2007-01-01

A novel experimental setup was designed to fabricate tungsten tips for scanning tunneling microscope (STM), based on simple mechanical lever principle. The equipment can quickly separate the tip from electrolyte to avoid the further etching of the fine-shaped tungsten tip. The setup is advantageous for its simplicity over complex electronic control systems. The use result in scanning electron microscope demonstrates that the radius of the tip can reach 50 nm. The tip was applied to scan the surface of highly-oriented pyrolytic graphite, and the results were satisfactory. It is shown that the tip can be used for the scanning of atomically resolved images. (authors)

Individualized tracking of self-directed motor learning in group-housed mice performing a skilled lever positioning task in the home cage.

Science.gov (United States)

Silasi, Gergely; Boyd, Jamie D; Bolanos, Federico; LeDue, Jeff M; Scott, Stephen H; Murphy, Timothy H

2018-01-01

Skilled forelimb function in mice is traditionally studied through behavioral paradigms that require extensive training by investigators and are limited by the number of trials individual animals are able to perform within a supervised session. We developed a skilled lever positioning task that mice can perform within their home cage. The task requires mice to use their forelimb to precisely hold a lever mounted on a rotary encoder within a rewarded position to dispense a water reward. A Raspberry Pi microcomputer is used to record lever position during trials and to control task parameters, thus making this low-footprint apparatus ideal for use within animal housing facilities. Custom Python software automatically increments task difficulty by requiring a longer hold duration, or a more accurate hold position, to dispense a reward. The performance of individual animals within group-housed mice is tracked through radio-frequency identification implants, and data stored on the microcomputer may be accessed remotely through an active internet connection. Mice continuously engage in the task for over 2.5 mo and perform ~500 trials/24 h. Mice required ~15,000 trials to learn to hold the lever within a 10° range for 1.5 s and were able to further refine movement accuracy by limiting their error to a 5° range within each trial. These results demonstrate the feasibility of autonomously training group-housed mice on a forelimb motor task. This paradigm may be used in the future to assess functional recovery after injury or cortical reorganization induced by self-directed motor learning. NEW & NOTEWORTHY We developed a low-cost system for fully autonomous training of group-housed mice on a forelimb motor task. We demonstrate the feasibility of tracking both end-point, as well as kinematic performance of individual mice, with each performing thousands of trials over 2.5 mo. The task is run and controlled by a Raspberry Pi microcomputer, which allows for cages to be

Physiological and subjective measures of workload when shovelling with a conventional and two-handled ('levered') shovel.

Science.gov (United States)

Bridger, R S; Cabion, N; Goedecke, J; Rickard, S; Schabort, E; Westgarth-Taylor, C; Lambert, M I

1997-11-01

Previous studies have suggested that the two-handled (levered) shovel is advantageous over the conventional spade from a biomechanical point of view. The aim of this experiment was to determine whether less energy was consumed while shovelling a load of sand with this shovel compared to a conventional tool. Accordingly, an experiment was designed in which subjects (n = 10) shovelled 1815 kg sand under laboratory conditions using either a conventional or a levered shovel. Heart rate and oxygen consumption were measured continuously during the trial and subjective data on perceived exertion, general fatigue and body discomfort were recorded after the trial. Although total energy expenditure was similar under both conditions (120 +/- 20 and 125 +/- 25 kcal; conventional versus two-handled spade), average heart rate was 4% higher when the two-handled shovel was used (p shovel (p shovel 1815 kg sand with the conventional shovel and the two-handled tool despite lower mass of sand per scoop with the latter. This can be explained by the fact that the increased mass of the additional handle compensated for the lower mass of sand per scoop. The higher average heart rate while shovelling with the two-handled shovel can be explained by the more erect posture.

Tactics at the category level of purchasing and supply management: sourcing levers, contingencies and performance

OpenAIRE

Hesping, Frank

2015-01-01

For the ‘front-line’ purchasing agent, it is obvious that not all categories of products and supplier relationships should be managed in the same way. Rather, in a modern category management approach, firms group similar products into ‘sourcing categories’ forming coherent supply markets (e.g., ‘metal sheets’, ‘leather’, ‘displays’, ‘cables’, etc.). Thus, to achieve cost reduction targets, a tailored mix of tactical sourcing levers for each sourcing category may be required. The fundamental q...

The effects of transverse rotation angle on compression and effective lever arm of prosthetic feet during simulated stance.

Science.gov (United States)

Major, Matthew J; Howard, David; Jones, Rebecca; Twiste, Martin

2012-06-01

Unlike sagittal plane prosthesis alignment, few studies have observed the effects of transverse plane alignment on gait and prosthesis behaviour. Changes in transverse plane rotation angle will rotate the points of loading on the prosthesis during stance and may alter its mechanical behaviour. This study observed the effects of increasing the external transverse plane rotation angle, or toe-out, on foot compression and effective lever arm of three commonly prescribed prosthetic feet. The roll-over shape of a SACH, Flex and single-axis foot was measured at four external rotation angle conditions (0°, 5°, 7° and 12° relative to neutral). Differences in foot compression between conditions were measured as average distance between roll-over shapes. Increasing the transverse plane rotation angle did not affect foot compression. However, it did affect the effective lever arm, which was maximized with the 5° condition, although differences between conditions were small. Increasing the transverse plane rotation angle of prosthetic feet by up to 12° beyond neutral has minimal effects on their mechanical behaviour in the plane of walking progression during weight-bearing.

Results of coalbed-methane drilling, Meadowfill Landfill, Harrison County, West Virginia: Chapter G.4 in Coal and petroleum resources in the Appalachian basin: distribution, geologic framework, and geochemical character

Science.gov (United States)

Ruppert, Leslie F.; Trippi, Michael H.; Fedorko, Nick; Grady, William C.; Eble, Cortland F.; Schuller, William A.; Ruppert, Leslie F.; Ryder, Robert T.

2014-01-01

The U.S. Environmental Protection Agency funded drilling of a borehole (39.33889°N., 80.26542°W.) to evaluate the potential of enhanced coalbed-methane production from unminable Pennsylvanian coal beds at the Meadowfill Landfill near Bridgeport, Harrison County, W. Va. The drilling commenced on June 17, 2004, and was completed on July 1, 2004. The total depth of the borehole was 1,081 feet (ft) and contained 1,053.95 ft of Pennsylvanian coal-bearing strata, and 27.05 ft of Mississippian strata.

Fostering development of nursing practices to support integrated care when implementing integrated care pathways: what levers to use?

Science.gov (United States)

Longpré, Caroline; Dubois, Carl-Ardy

2017-11-29

Care integration has been the focus of recent health system reforms. Given their functions at all levels of the care continuum, nurses have a substantial and primordial role to play in such integration processes. The aim of this study was to identify levers and strategies that organizations can use to support the development of a nursing practice aligned with the requirements of care integration in a health and social services centre (HSSC) in Quebec. The research design was a cross-sectional descriptive qualitative study based on a single case study with nested levels of analysis. The case was a public, multi-disciplinary HSSC in a semi-urban region of Quebec. Semi-structured interviews with 37 persons (nurses, professionals, managers, administrators) allowed for data saturation and ensured theoretical representation by covering four care pathways constituting different care integration contexts. Analysis involved four steps: preparing a predetermined list of codes based on the reference framework developed by Minkman (2011); coding transcript content; developing general and summary matrices to group observations for each care pathway; and creating a general model showing the overall results for the four pathways. The organization's capacity for response with regard to developing an integrated system of services resulted in two types of complementary interventions. The first involved investing in key resources and renewing organizational structures; the second involved deploying a series of organizational and clinical-administrative processes. In resource terms, integration efforts resulted in setting up new strategic services, re-arranging physical infrastructures, and deploying new technological resources. Organizational and clinical-administrative processes to promote integration involved renewing governance, improving the flow of care pathways, fostering continuous quality improvement, developing new roles, promoting clinician collaboration, and strengthening

Health as a lever for another development.

Science.gov (United States)

Banerji, D

1978-01-01

In India the health services are unable to meet the real needs of the poor. The colonial policy of exploitation, expropriation and plunder created widespread disruption in the way of life of the Indian people. The colonialism destroyed the health culture of India and created a Western bias in the health services which continues to this day. The bias has extend to research - for example, by postulating a correlation between malnutrition and mental retardation. The commitment of the current political leadership to bypass the medical establishment and go directly to the people has created a favorable setting to challenge the basic scientific, sociological and economic premises of the earlier approach to development of the health services in India, and to formulate a new approach to development of the health services in India, and to formulate a new approach to take its place. The main premise of Another Development in the health services is to begin with the people - a framework is designed for a health service system particularly tailored to meet the needs of the people. Efforts to relieve the suffering caused by health problems can contribute to the initiation of political, economic and social action. In this context, the formulation and implementation of Another Development in Health acquires much significance: 1) the very alleviation of suffering has political significance, because it narrows the gap between the ruling classes and the masses; 2) Another Development in Health would provide an entry point for change agents, who could use the opportunity to work with the people to initiate changes in other social and economic fields; and 3) by generating social awareness, Another Development in Health may work as a lever for promoting similar developments in other social and economic fields.

Development of an indirect counterbalanced pendulum optical-lever thrust balance for micro- to millinewton thrust measurement

International Nuclear Information System (INIS)

Grubišić, A N; Gabriel, S B

2010-01-01

This paper describes the design and testing of an indirect hanging pendulum thrust balance using a laser-optical-lever principle to provide micro- to millinewton thrust measurement for the development of electric propulsion systems. The design philosophy allows the selection of the total thrust range in order to maximize resolution through a counterbalanced pendulum principle, as well as passive magnetic damping in order to allow relatively rapid transient thrust measurement. The balance was designed for the purpose of hollow cathode microthruster characterization, but could be applied to other electric propulsion devices in the thrust range of micro- to millinewtons. An initial thrust characterization of the T5 hollow cathode is presented

[Therapeutic education in pediatric dentistry: analysis of obstacles and levers to the development of programmes in France in 2016].

Science.gov (United States)

Marquillier, Thomas; Trentesaux, Thomas; Gagnayre, Rémi

2017-01-01

Over recent years, therapeutic patient education has become part of dental medicine. Management of early childhood caries, known to be a very common chronic disease, has evolved to include an educational dimension. The objective of this study was to identify the levers and barriers to the development of formalized therapeutic education programmes and alternatives. A comprehensive exploratory qualitative study was conducted between November 2015 and June 2016 on a targeted sample of 15 people aware of the problem of TPE in dentistry. The study showed that TPE training in dentistry is underdeveloped, despite its numerous benefits: change of the healthcare professional's approach, implementation of structured educational programmes, development of research, etc. There are many obstacles to the development of TPE programmes: insufficient resources, rigid legislation or lack of knowledge of TPE practices. The dental profession is an obstacle itself because of its lack of understanding and variable degrees of integration the medical community. There are multiple levers, but the main ones are changing attitudes of the profession and the provision of resources to develop TPE. Although alternatives to TPE programmes exist (accompanying measures, short educational strategies, connected health), they cannot replace TPE. More educational strategies must be developed in the field of dentistry. However, the framework of TPE must be adapted to the profession to ensure good uptake.

Estimation of Lifetime Duration for a Lever Pin of Runner Blade Operating Mechanism using a Graphic – analytic Method

Directory of Open Access Journals (Sweden)

Ana-Maria Budai

2015-09-01

Full Text Available In this paper are presented a graphic - analytic method that can be used to estimate the fatigue lifetime duration for an operating mechanism lever pin to a Kaplan turbine. The presented calculus algorithm is adapted from the one used by Fuji Electric to made strength calculus in order to refurbish a Romanian hydropower plant, equipped with a Kaplan turbine. The graphic part includes a 3D fatigue diagram for rotating bending stress designed by Fuji Electric specialists.

Wave energy, lever operated pivoting float LOPF study

Energy Technology Data Exchange (ETDEWEB)

Margheritini, L.

2012-11-01

The fully instrumented Resen Waves Lever Operated Pivoting Float LOPF wave energy buoy model has gone through the first stage of testing in regular waves in scale 1:25 of the North Sea wave conditions, in the 3D deep wave basin at the Hydraulic and Coastal Engineering Laboratory of Aalborg University in Denmark. The model size was 60cm W x 90cm L x 21cm H. The 60 cm width pointed towards the wave front. The LOPF buoy is characterized by a simple mechanical design with few moving parts and direct electrical output and it is taut moored to the sea bed, so all forces are referenced to the seabed for maximum energy output in regular as well as irregular waves. During storms the buoy pivots and streamlines itself to minimize loads on the mooring line. A conservative estimate shows that a full scale system for North Sea conditions has a float size width of 15 m that will, with 60% generator efficiency, produce 610 MWh/y (609.497 kWh/y) with an average power output of 69.6 kW, which requires a generator capacity of 700 kW. It is expected the generator efficiency can be increased to 90% in the future. More specific calculations (from EnergiNet) show that with one generator of 695 kW the expected power production is 585 MWh/y; with a generator of 250 kW and 100 kW, the expected power production is 481 MWh/y and 182 MWh/y respectively. In addition there are several areas for future improvements for increased power production. (Author)

Effects of nucleus accumbens core and shell lesions on autoshaped lever-pressing.

Science.gov (United States)

Chang, Stephen E; Holland, Peter C

2013-11-01

Certain Pavlovian conditioned stimuli (CSs) paired with food unconditioned stimuli (USs) come to elicit approach and even consumption-like behaviors in rats (sign-tracking). We investigated the effects of lesions of the nucleus accumbens core (ACbC) or shell (ACbS) on the acquisition of sign-tracking in a discriminative autoshaping procedure in which presentation of one lever CS was followed by delivery of sucrose, and another was not. Although we previously found that bilateral lesions of the whole ACb disrupted the initial acquisition of sign-tracking, neither ACbC or ACbS lesions affected the rate or percentage of trials in which rats pressed the CS+. In addition, detailed video analysis showed no effect of either lesion on the topography of the sign-tracking conditioned response (CR). These and other results from lesion studies of autoshaping contrast with those from previous sign-tracking experiments that used purely visual cues (Parkinson et al., 2000a,b), suggesting that the neural circuitry involved in assigning incentive value depends upon the nature of the CS. Copyright © 2013 Elsevier B.V. All rights reserved.

Genomic characterisation of Almpiwar virus, Harrison Dam virus and Walkabout Creek virus; three novel rhabdoviruses from northern Australia

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Jane McAllister

2014-09-01

Full Text Available Rhabdoviridae represent a diverse group of viruses with the potential to cause disease in humans, animals and plants. Currently there are nine genera in the family; however a large number of rhabdoviruses remain unassigned. Here we characterise three novel rhabdoviruses genomes. Almpiwar virus (ALMV, isolated from skinks in northern Queensland, is the first completely sequenced rhabdovirus from squamates, with serological studies indicating multiple animal host species. Harrison Dam virus (HARDV and Walkabout Creek virus (WACV were isolated from mosquitoes in the Northern Territory and biting midges in southern Queensland respectively and their vertebrate hosts remain unknown. Serological cross-neutralisation tests with other Australian rhabdoviruses indicate that ALMV, WACV and HARDV are distinct viruses with little antigenic cross-reactivity. Next-generation sequencing revealed that all viruses encode the core proteins common to rhabdoviruses (N, P, M, G and L, plus additional ORFs between the M and G genes. HARDV also contains a small ORF between the G and L genes. Phylogenetic analysis of N and L proteins suggests that HARDV and WACV share a common lineage with the tupaviruses and Sandjimba group, whereas ALMV is a distinct and divergent virus showing no clear relationship to any rhabdovirus except the recently characterised Niahka virus (NIAV.

STEM-based workbook: Enhancing students' STEM competencies on lever system

Science.gov (United States)

Sejati, Binar Kasih; Firman, Harry; Kaniawati, Ida

2017-05-01

Twenty-first century is a century of technology, a rapid development of scientific studies and technology make them relied heavily on each other. This research investigated about the effect of STEM-based workbook in enhancing students' STEM competencies in terms of knowledge understanding, problem solving skill, innovative abilities, and responsibility. The workbook was tried on 24 students that applied engineering design processes together with mathematics and science knowledge to design and create an egg cracker. The result showed that the implementation of STEM-based workbook on lever system in human body is effective to improve students' STEM competencies, it can be proven by students' result on their knowledge understanding improvement which can be seen from normalized gain () score is 0.41 and categorized as medium improvement, students' problem solving skill is also improving where it obtained a medium improvement with normalized gain as much as 0.45. Innovative abilities also encountered an the improvement, the workbook analysis obtained a higher score which means students can be more innovative after finishing their workbook. Last, students' responsibility is keep improving day by day, students' effort gain the highest score it means that the students become more responsible after implementation of STEM-based workbook. All of the results are supported with the response of students towards STEM-based workbook implementation which showed positive response in all indicators.

Effects of psychotropic agents on extinction of lever-press avoidance in a rat model of anxiety vulnerability

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Xilu eJiao

2014-09-01

Full Text Available Avoidance and its perseveration represent key features of anxiety disorders. Both pharmacological and behavioral approaches (i.e. anxiolytics and extinction therapy have been utilized to modulate avoidance behavior in patients. However, the outcome has not always been desirable. Part of the reason is attributed to the diverse neuropathology of anxiety disorders. Here, we investigated the effect of psychotropic drugs that target various monoamine systems on extinction of avoidance behavior using lever-press avoidance task. Here we used the Wistar-Kyoto (WKY rat, a unique rat model that exhibits facilitated avoidance and extinction resistance along with malfunction of the dopamine (DA system. Sprague Dawley (SD and WKY rats were trained to acquire lever-press avoidance. WKY rats acquired avoidance faster and to a higher level compared to SD rats. During pharmacological treatment, bupropion, and desipramine significantly reduced avoidance response selectively in WKY rats. However, after the discontinuation of drug treatment, only those WKY rats that were previously treated with desipramine exhibited lower avoidance response compared to the control group. In contrast, none of the psychotropic drugs facilitated avoidance extinction in SD rats. Instead, desipramine impaired avoidance extinction and increased non-reinforced response in SD rats. Interestingly, paroxetine, a widely used antidepressant and anxiolytic, exhibited the weakest effect in WKY rats and no effects at all in SD rats. Thus, our data suggest that malfunctions in brain catecholamine system could be one of the underlying etiologies of anxiety-like behavior, particularly avoidance perseveration. Pharmacological manipulation targeting DA and norepinephrine is more effective to facilitate extinction learning in this strain. The data from the present study may shed light on new pharmacological approaches to treat patients with anxiety disorders who are not responding to serotonin re

Parrotfish grazing ability: interspecific differences in relation to jaw-lever mechanics and relative weight of adductor mandibulae on an Okinawan coral reef

OpenAIRE

Nanami, Atsushi

2016-01-01

Parrotfishes (family Labridae: Scarini) are regarded to have important roles for maintaining the ecosystem balance in coral reefs due to their removal of organic matter and calcic substrates by grazing. The purpose of the present study was to clarify the interspecific differences in grazing ability of five parrotfish species (Chlorurus sordidus, C. bowersi, Scarus rivulatus, S. niger and S. forsteni) in relation to interspecific differences in jaw-lever mechanics and the relative weight of th...

Analysis of barriers and levers to the implementation of strategies of adaptation to climate changes - 2014-2015. The case of urban communities. Final report

International Nuclear Information System (INIS)

Simonet, Guillaume; Leseur, Alexia

2015-12-01

This is the final report of a research project (ABSTRACT-colurba) which aimed at exploring decision mechanisms and organisational dynamics underlying the elaboration of strategies of adaptation to climate changes by using results of a field study among ten previously selected French local communities. The objectives were to determine priority local social and economic challenges associated with expected impacts of climate changes, to identify economic, organisational and cognitive barriers and levers (at the State, representative or collectivity level) to an optimal implementation of measures of reduction of local vulnerabilities to climate changes, to identify possible or already used diagnosis tools for the assessment of costs and of priority investments, and to make comparisons with other referenced cases and to assess possibilities to bypass barriers thanks to a dialogue with stakeholders. After a presentation of the project (objectives, institutional context, guides and methodologies, scientific approach for data acquisition and analysis), the report presents and discusses the obtained results regarding the place given to adaptation in local policies (PCET, the French local climate-energy plans), representations of adaptation, the inclusion of adaptation in the agenda of public climatic action, tools to make adaptation operational, barriers and levers to action implementation

National uranium resource evaluation. Uranium hydrogeochemical and stream sediment reconnaissance of the Harrison Bay NTMS quadrangle, Alaska

International Nuclear Information System (INIS)

Langfeldt, S.L.; Hardy, L.C.; D'Andrea, R.F. Jr.; Zinkl, R.J.; Shettel, D.L. Jr.; Minor, M.M.; McInteer, C.; Hansel, J.N.; Broxton, D.E.

1982-03-01

This report presents results of a Hydrogeochemical and Stream Sediment Reconnaissance (HSSR) of the Harrison Bay NTMS quadrangle, Alaska. In addition to this abbreviated data release, more complete data are available to the public in machine-readable form. These machine-readable data, as well as quarterly or semiannual program progress reports containing further information on the HSSR program in general, or on the Los Alamos National Laboratory (LANL) portion of the program in particular, are available from DOE's Technical Library at its Grand Junction Area Office. Presented in this data release are location data, field analyses, and laboratory analyses of several different sample media. For the sake of brevity, many field site observations have not been included in this volume; these data are, however, available on the magnetic tape. Appendices A and B describe the sample media and summarize the analytical results for each medium. The data have been subdivided by one of the Los Alamos National Laboratory sorting programs of Zinkl and others (1981a) into groups of stream-sediment and lake-sediment samples. For each group which contains a sufficient number of observations, statistical tables, tables of raw data, and 1:1,000,000 scale maps of pertinent elements have been included in this report. Also included are maps showing results of multivariate statistical analyses. Information on the field and analytical procedures used by the Los Alamos National laboratory during sample collection and analysis may be found in any HSSR data release prepared by the Laboratory and will not be included in this report

Fight against fuel poverty. Levers, stakes and expectations of the fight against fuel poverty in housing

International Nuclear Information System (INIS)

Payen, Luc; Pamart, Isabelle; Lacroix, Olivier

2013-10-01

'Is in fuel poverty a person who feels in his particular housing difficulties have the necessary energy supply to the satisfaction of basic needs due to the inadequacy of resources or its habitat conditions'. The rising cost of energy commodities in the late 2000's, added to the poor thermal quality an important part of French homes, has led to the emergence of fuel poverty in the public debate. Legislative recognition of these situations with the law 'Grenelle II' (from which is extracted the definition above) marked a decisive step in the fight against this complex problem. Affecting nearly 5 million households in France, fuel poverty is a major challenge for societies wishing to successfully achieve their energy transition. In this new publication, ENEA reports on the main levers of the fight against fuel poverty, the obstacles encountered and the needs for new solutions

Mi Segundo Libro de Maquinas Simples: Las Palancas. Escuela Intermedia Grados 7, 8 y 9 (My Second Book of Simple Machines: Levers. Intermediate School Grades 7, 8, and 9).

Science.gov (United States)

Alvarado, Patricio R.; Montalvo, Luis

This is the second book in a five-book physical science series on simple machines. The books are designed for Spanish-speaking junior high school students. By suggesting experiments and posing questions concerning drawings in the book which illustrate the scientific principles, this book explains the workings of three types of levers. Resistance…

Tippvormis Harrison Ford / Harrison Ford ; toim. Robert Aps

Index Scriptorium Estoniae

Ford, Harrison

2008-01-01

Näitleja järjekordse Indiana Jones'i filmi "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") väljatuleku eel. Sama ka Teleleht nr. 23, lk. 47 : ill

Réécritures du mythe d’Orphée et enjeux esthétiques, philosophiques et formels dans The Mask of Orpheus de Harrison Birtwistle Aesthetic, Philosophical and Formal Questions Raised by the Rewritings of the Myth of Orpheus in Harrison Birtwistle’s The Mask of Orpheus

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Jean-Philippe Héberlé

2009-08-01

Full Text Available This article deals with Harrison Birtwistle’s rewriting of the myth of Orpheus in his opera The Mask of Orpheus (1986. Written on a libretto by Peter Zinovieff, The Mask of Orpheus is part of a long tradition of operas dealing with the famous Greek myth. Yet, the way it is tackled by Birtwistle and Zinovieff is very different from what was done in the past. They do not present the spectator with the key elements of the story in a linear way but simultaneously. Different versions of the myth are introduced and sometimes we are presented with contradictory versions at the same time to force us to be active and aware of the existence of different kinds of dualities. The simultaneous presentation of some events is also connected to the way Birtwistle and Zinovieff play with the notion of time in their opera. One of their aims is to show how memory functions. When you remember something the frontier between past and present is blurred and the remembrance of things past is part of an endless cycle where things are perpetually brought to life, a very important aspect of myths whose universal and timeless nature is thus emphasized. Rituals, like myths, are based on the idea of repetition as well as on the idea of returning to the origins. This is why the opera may be considered as a ritualistic piece of work; this is underlined by the omnipresence of the figure three—a ritual number—in the literary and musical structure of The Mask of Orpheus.

Program realization of mathematical model of kinetostatical calculation of flat lever mechanisms

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M. A. Vasechkin

2016-01-01

Full Text Available Global computerization determined the dominant position of the analytical methods for the study of mechanisms. As a result, kinetostatics analysis of mechanisms using software packages is an important part of scientific and practical activities of engineers and designers. Therefore, software implementation of mathematical models kinetostatical calculating mechanisms is of practical interest. The mathematical model obtained in [1]. In the language of Turbo Pascal developed a computer procedure that calculates the forces in kinematic pairs in groups Assur (GA and a balancing force at the primary level. Before use appropriate computational procedures it is necessary to know all external forces and moments acting on the GA and to determine the inertial forces and moments of inertia forces. The process of calculations and constructions of the provisions of the mechanism can be summarized as follows. Organized cycle in which to calculate the position of an initial link of the mechanism. Calculate the position of the remaining links of the mechanism by referring to relevant procedures module DIADA in GA [2,3]. Using the graphics mode of the computer displaying on the display the position of the mechanism. The computed inertial forces and moments of inertia forces. Turning to the corresponding procedures of the module, calculated all the forces in kinematic pairs and the balancing force at the primary level. In each kinematic pair build forces and their direction with the help of simple graphical procedures. The magnitude of these forces and their direction are displayed in a special window with text mode. This work contains listings of the test programs MyTеst, is an example of using computing capabilities of the developed module. As a check on the calculation procedures of module in the program is reproduced an example of calculating the balancing forces according to the method of Zhukovsky (Zhukovsky lever.

The Conditions of Formation and the Regulation Levers of the «New Economy» as a Modern Phenomenon

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Goncharova Svitlana Yu.

2017-03-01

Full Text Available The article is concerned with studying the stages of formation and development of phenomenon of the «new economy». Interpretation of the concept of «new economy» by foreign and by domestic scholars has been considered, the historical origin of the term of «new economy» has been defined, principles of its formation have been explored. The authors used reports by the World Bank on the level of development of the knowledge-based economy. Two combined index – the Knowledge Economy Index and the Knowledge Index have been provided, together with the accompanying rating of the world countries. The factors, determining the development of innovation process: economic, technological, political, legal, socio-psychological, cultural, organizational, and managerial, have been identified. Problems of establishing the national innovation system in Ukraine have been defined and ways of overcoming them have been suggested. The authors have developed and graphically presented the scheme of the conditions of formation and the regulation levers of the «new economy».

Food quality and motivation: a refined low-fat diet induces obesity and impairs performance on a progressive ratio schedule of instrumental lever pressing in rats.

Science.gov (United States)

Blaisdell, Aaron P; Lau, Yan Lam Matthew; Telminova, Ekatherina; Lim, Hwee Cheei; Fan, Boyang; Fast, Cynthia D; Garlick, Dennis; Pendergrass, David C

2014-04-10

Purified high-fat diet (HFD) feeding causes deleterious metabolic and cognitive effects when compared with unrefined low-fat diets in rodent models. These effects are often attributed to the diet's high content of fat, while less attention has been paid to other mechanisms associated with the diet's highly refined state. Although the effects of HFD feeding on cognition have been explored, little is known about the impact of refined vs. unrefined food on cognition. We tested the hypothesis that a refined low-fat diet (LFD) increases body weight and adversely affects cognition relative to an unrefined diet. Rats were allowed ad libitum access to unrefined rodent chow (CON, Lab Diets 5001) or a purified low-fat diet (REF, Research Diets D12450B) for 6 months, and body weight and performance on an instrumental lever pressing task were recorded. After six months on their respective diets, group REF gained significantly more weight than group CON. REF rats made significantly fewer lever presses and exhibited dramatically lower breaking points than CON rats for sucrose and water reinforcement, indicating a chronic reduction of motivation for instrumental performance. Switching the rats' diet for 9 days had no effect on these measures. Diet-induced obesity produces a substantial deficit in motivated behavior in rats, independent of dietary fat content. This holds implications for an association between obesity and motivation. Specifically, behavioral traits comorbid with obesity, such as depression and fatigue, may be effects of obesity rather than contributing causes. To the degree that refined foods contribute to obesity, as demonstrated in our study, they may play a significant contributing role to other behavioral and cognitive disorders. Copyright © 2014 Elsevier Inc. All rights reserved.

Program realization of mathematical model of kinematic calculation of flat lever mechanisms

Directory of Open Access Journals (Sweden)

M. A. Vasechkin

2016-01-01

Full Text Available Calculation of kinematic mechanisms is very time-consuming work. Due to the content of a large number of similar operations can be automated using computers. Forthis purpose, it is necessary to implement a software implementation ofthe mathematical model of calculation of kinematic mechanisms of the second class. In the article on Turbo Pascal presents the text module to library procedures all kinematic studies of planar lever mechanisms of the second class. The determination of the kinematic characteristics of the mechanism and the construction of its provisions, plans, plans, speeds and accelerations carried out on the example of the six-link mechanism. The beginning of the motionless coordinate system coincides with the axis of rotation of the crank AB. It is assumed that the known length of all links, the positions of all additional points of links and the coordinates of all kinematic pairs rack mechanism, i.e. this stage of work to determine the kinematics of the mechanism must be preceded by a stage of synthesis of mechanism (determining missing dimensions of links. Denote the coordinates of point C and considering that the analogues of velocities and accelerations of this point is 0 (stationary point, appeal to the procedure that computes the kinematics group the Assyrians (GA third. Specify kinematic parameters of point D, taking the beginning of the guide slide E at point C, the angle, the analogue of the angular velocity and the analogue of the angular acceleration of the guide is zero, knowing the length of the connecting rod DE and the length of link 5, refer to the procedure for the GA of the second kind. The use of library routines module of the kinematic calculation, makes it relatively simple to organize a simulation of the mechanism motion, to calculate the projection analogues of velocities and accelerations of all links of the mechanism, to build plans of the velocities and accelerations at each position of the mechanism.

Color Shaded-Relief and Surface-Classification Maps of the Fish Creek Area, Harrison Bay Quadrangle, Northern Alaska

Science.gov (United States)

Mars, John L.; Garrity, Christopher P.; Houseknecht, David W.; Amoroso, Lee; Meares, Donald C.

2007-01-01

-relief and surface-classification data (sheet 3). Remote sensing datasets that were used to compile the maps include Landsat 7 Enhanced Thematic Mapper+ (ETM+), and interferometric synthetic aperture radar (IFSAR) data. In addition, a 1:250,000-scale geologic map of the Harrison Bay quadrangle, Alaska (Carter and Galloway, 1985, 2005) was used in conjunction with ETM+ and IFSAR data.

Harrison Ford : opjat skripit potertoje sedlo... / Harrison Ford ; interv. Barbara Hanson

Index Scriptorium Estoniae

Ford, Harrison

2008-01-01

Näitleja järjekordse (arvult neljanda, 19-aastase vaheaja järel!) Indiana Jones'i filmi "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") väljatuleku eel. Väljaandest Famous

Disinhibition by propranolol and chlordiazepoxide of nonrewarded lever-pressing in the rat is unaffected by dorsal noradrenergic bundle lesion.

Science.gov (United States)

Salmon, P; Tsaltas, E; Gray, J A

1989-03-01

Ten male Sprague-Dawley rats received 6-hydroxydopamine-induced lesions of the dorsal noradrenergic bundle and 10 others underwent control operations. The lesion depleted levels of noradrenaline in the hippocampus to 2% of those in the controls. All rats were then trained for 16 sessions to lever-press in a Skinner box on a variable interval 18 sec schedule of food-reinforcement, then for 42 days on a successive discrimination between periods of variable interval (VI 18 sec) food-reinforcement and periods of extinction. This report describes the effects of chlordiazepoxide (CDP; 5 mg/kg) and propranolol (5 and 10 mg/kg) injected intraperitoneally in both groups on modified ABBA designs after this training. Both drugs increased the response rates in extinction periods. The effect of propranolol was similar at each dose and smaller than that of CDP. Although CDP and propranolol (5 mg/kg) increased variable interval response rates also, this could not account for the effect on extinction response rates. Responding did not differ between the lesioned and control animals and the effects of drugs were similar in each group. It is unlikely that CDP or propranolol release nonrewarded responding by disrupting transmission in the dorsal noradrenergic bundle.

Levers for Language Growth: Characteristics and Predictors of Language Trajectories between 4 and 7 Years.

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Cristina McKean

Full Text Available Evidence is required as to when and where to focus resources to achieve the greatest gains for children's language development. Key to these decisions is the understanding of individual differences in children's language trajectories and the predictors of those differences. To determine optimal timing we must understand if and when children's relative language abilities become fixed. To determine where to focus effort we must identify mutable factors, that is those with the potential to be changed through interventions, which are associated with significant differences in children's language scores and rate of progress.Uniquely this study examined individual differences in language growth trajectories in a population sample of children between 4 and 7 years using the multilevel model for change. The influence of predictors, grouped with respect to their mutability and their proximity to the child (least-mutable, mutable-distal, mutable-proximal, were estimated.A significant degree of variability in rate of progress between 4 and 7 years was evident, much of which was systematically associated with mutable-proximal factors, that is, those factors with evidence that they are modifiable through interventions with the child or family, such as shared book reading, TV viewing and number of books in the home. Mutable-distal factors, such as family income, family literacy and neighbourhood disadvantage, hypothesised to be modifiable through social policy, were important predictors of language abilities at 4 years.Potential levers for language interventions lie in the child's home learning environment from birth to age 4. However, the role of a family's material and cultural capital must not be ignored, nor should the potential for growth into the school years. Early Years services should acknowledge the effects of multiple, cascading and cumulative risks and seek to promote child language development through the aggregation of marginal gains in the pre

Areas of progress towards a factor 4 territorial coherence scheme. Which local levers for a post-carbon conurbation? Final report - Scenario 2020-2030

International Nuclear Information System (INIS)

Beauvais, Jean Marie; Metais, Benedicte; Baratier, Jerome; Vidalenc, Eric

2011-01-01

Taking the Tours conurbation as an example, this study examines how to elaborate and define a new territorial coherence scheme (a land and urban planning tool) which would include a planned reduction of greenhouse gas emissions by a factor 4 between 2020 and 2030. It is therefore a prospective study with 2006 as a reference year (reductions are assessed with respect to 2006 due to data availability). After an analysis of the reference situation (2006) and of objectives, the report presents the scenario for 2020-2030, analyses the various levers in different sectors (mobility, housing, office building, industry and construction, agriculture), and examines possibilities related to the production of renewable energy, the adaptation to climate change, the creation of a new governance to mitigate and to adapt to climate change. Expected gains are discussed for transports, housing, office building, industry, agriculture, renewable energies, and adaptation. The last part reports a sensitive approach to a post-carbon world through different workshops (with children or within a fiction writing workshop)

Incongruous Objects

DEFF Research Database (Denmark)

Damkjær, Maria

2014-01-01

Review of Jonathon Shears and Jen Harrison (ends), Literary Bric-à-Brac and the Victorians: From Commodities to Oddities.......Review of Jonathon Shears and Jen Harrison (ends), Literary Bric-à-Brac and the Victorians: From Commodities to Oddities....

Assisted extraction of the energy level spacings and lever arms in direct current bias measurements of one-dimensional quantum wires, using an image recognition routine

International Nuclear Information System (INIS)

Lesage, A. A. J.; Smith, L. W.; Griffiths, J. P.; Farrer, I.; Jones, G. A. C.; Ritchie, D. A.; Smith, C. G.; Al-Taie, H.; Kelly, M. J.; See, P.

2015-01-01

A multiplexer technique is used to individually measure an array of 256 split gates on a single GaAs/AlGaAs heterostructure. This results in the generation of large volumes of data, which requires the development of automated data analysis routines. An algorithm is developed to find the spacing between discrete energy levels, which form due to transverse confinement from the split gate. The lever arm, which relates split gate voltage to energy, is also found from the measured data. This reduces the time spent on the analysis. Comparison with estimates obtained visually shows that the algorithm returns reliable results for subband spacing of split gates measured at 1.4 K. The routine is also used to assess direct current bias spectroscopy measurements at lower temperatures (50 mK). This technique is versatile and can be extended to other types of measurements. For example, it is used to extract the magnetic field at which Zeeman-split 1D subbands cross one another

Unintended costs and consequences of school closures implemented in preparation for Hurricane Isaac in Harrison County School District, Mississippi, August-September 2012.

Directory of Open Access Journals (Sweden)

Yenlik Zheteyeva

Full Text Available School closures, while an effective measure against the spread of disease during a pandemic, may carry unintended social and economic consequences for students and families. We evaluated these costs and consequences following a 4-day school closure in Mississippi's Harrison County School District (HCSD.In a survey of all households with students enrolled in HCSD, we collected information on difficulties related to the school closure, including interruption of employment and pay, loss of access to subsidized school meals, and arrangement of alternative childcare. We analyzed this information in the context of certain demographic characteristics of the survey respondents and households, such as race, level of education, and income. We also estimated the average number of lost work days and documented the childcare alternatives chosen by households affected by the school closure.We received 2,229 (28.4% completed surveys from an estimated 7,851 households eligible to participate. About half (1,082 [48.5%] of the households experienced at least some difficulty during the closure, primarily in three areas: uncertainty about duration of the closure, lost income, and the effort of arranging alternate childcare. Adults working outside the home, particularly the major wage earner in the household, were more likely to suffer lost income while schools were closed, an effect mitigated by paid leave benefits. Difficulty arranging childcare was reported most frequently by respondents with lower levels of education and households with younger children. Beyond the top three concerns expressed by households in HCSD, the survey also shed light on the issue of food insecurity when subsidized school meals are not available. Reported by 17.9% of households participating in the subsidized school lunch program, difficulty providing meals during the closure was associated with higher numbers of dependent children, selection of "other" as the race of the household

Implications for Educational Classification and Psychological Diagnoses Using the Wechsler Adult Intelligence Scale-Fourth Edition with Canadian versus American Norms

Science.gov (United States)

Harrison, Allyson G.; Holmes, Alana; Silvestri, Robert; Armstrong, Irene T.

2015-01-01

Building on a recent work of Harrison, Armstrong, Harrison, Iverson and Lange which suggested that Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) scores might systematically overestimate the severity of intellectual impairments if Canadian norms are used, the present study examined differences between Canadian and American derived…

Ordene lever

DEFF Research Database (Denmark)

Davidsen-Nielsen, Niels

2016-01-01

Eftertanken. Shakespeare er så stor, at han til næsten enhver lejlighed er leveringsdygtig med en tankevækkende formulering.......Eftertanken. Shakespeare er så stor, at han til næsten enhver lejlighed er leveringsdygtig med en tankevækkende formulering....

Reference: 696 [Arabidopsis Phenome Database[Archive

Lifescience Database Archive (English)

Full Text Available 696 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18047472i Harrison B...gravity signal transduction pathway in root statocytes. 2 380-92 18047472 2008 Jan The Plant journal Harrison Benjamin R|Masson Patrick H

A pilot study of a new spectrophotometry device to measure tissue oxygen saturation.

Science.gov (United States)

Abel, Gemma; Allen, John; Drinnan, Michael

2014-09-01

Tissue oxygen saturation (SO2) measurements have the potential for far wider use than at present but are limited by device availability and portability for many potential applications. A device based on a small, low-cost general-purpose spectrophotometer (the Harrison device) might facilitate wider use. The aim of this study was to compare the Harrison device with a commercial instrument, the LEA O2C.Measurements were carried out on the forearm and finger of 20 healthy volunteers, using a blood pressure cuff on the upper arm to induce different levels of oxygenation. Repeatability of both devices was assessed, and the Bland-Altman method was used to assess agreement between them.The devices showed agreement in overall tracking of changes in SO2. Test-retest agreement for the Harrison device was worse than for O2C, with SD repeatability of 10.6% (forearm) or 18.6% (finger). There was no overall bias between devices, but mean (SD) difference of 1.2 (11.8%) (forearm) or 4.4 (11.5%) (finger) were outside of a clinically acceptable range.Disagreements were attributed to the stability of the Harrison probe and the natural SO2 variations across the skin surface increasing the random error. Therefore, though not equivalent to the LEA O2C, a probe redesign and averaged measurements may help establish the Harrison device as a low cost alternative.

A pilot study of a new spectrophotometry device to measure tissue oxygen saturation

International Nuclear Information System (INIS)

Abel, Gemma; Allen, John; Drinnan, Michael

2014-01-01

Tissue oxygen saturation (SO2) measurements have the potential for far wider use than at present but are limited by device availability and portability for many potential applications. A device based on a small, low-cost general-purpose spectrophotometer (the Harrison device) might facilitate wider use. The aim of this study was to compare the Harrison device with a commercial instrument, the LEA O2C. Measurements were carried out on the forearm and finger of 20 healthy volunteers, using a blood pressure cuff on the upper arm to induce different levels of oxygenation. Repeatability of both devices was assessed, and the Bland–Altman method was used to assess agreement between them. The devices showed agreement in overall tracking of changes in SO2. Test–retest agreement for the Harrison device was worse than for O2C, with SD repeatability of 10.6% (forearm) or 18.6% (finger). There was no overall bias between devices, but mean (SD) difference of 1.2 (11.8%) (forearm) or 4.4 (11.5%) (finger) were outside of a clinically acceptable range. Disagreements were attributed to the stability of the Harrison probe and the natural SO2 variations across the skin surface increasing the random error. Therefore, though not equivalent to the LEA O2C, a probe redesign and averaged measurements may help establish the Harrison device as a low cost alternative. (paper)

HYDRAULICS, HARRISON COUNTY, KENTUCKY, USA

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

FLOODPLAIN MAPPING, HARRISON COUNTY, IA

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

TERRAIN, HARRISON COUNTY, KENTUCKY USA

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — Terrain data, as defined in FEMA Guidelines and Specifications, Appendix N: Data Capture Standards, describes the digital topographic data that was used to create...

Drug versus sweet reward: greater attraction to and preference for sweet versus drug cues.

Science.gov (United States)

Madsen, Heather B; Ahmed, Serge H

2015-05-01

Despite the unique ability of addictive drugs to directly activate brain reward circuits, recent evidence suggests that drugs induce reinforcing and incentive effects that are comparable to, or even lower than some nondrug rewards. In particular, when rats have a choice between pressing a lever associated with intravenous cocaine or heroin delivery and another lever associated with sweet water delivery, most respond on the latter. This outcome suggests that sweet water is more reinforcing and attractive than either drug. However, this outcome may also be due to the differential ability of sweet versus drug levers to elicit Pavlovian feeding-like conditioned responses that can cause involuntary lever pressing, such as pawing and biting the lever. To test this hypothesis, rats first underwent Pavlovian conditioning to associate one lever with sweet water (0.2% saccharin) and a different lever with intravenous cocaine (0.25 mg) or heroin (0.01 mg). Choice between these two levers was then assessed under two operant choice procedures: one that permitted the expression of Pavlovian-conditioned lever press responses during choice, the other not. During conditioning, Pavlovian-conditioned lever press responses were considerably higher on the sweet lever than on either drug lever, and slightly greater on the heroin lever than on the cocaine lever. Importantly, though these differences in Pavlovian-conditioned behavior predicted subsequent preference for sweet water during choice, they were not required for its expression. Overall, this study confirms that rats prefer the sweet lever because sweet water is more reinforcing and attractive than cocaine or heroin. © 2014 Society for the Study of Addiction.

On geometric approach to Lie symmetries of differential-difference equations

International Nuclear Information System (INIS)

Li Hongjing; Wang Dengshan; Wang Shikun; Wu Ke; Zhao Weizhong

2008-01-01

Based upon Cartan's geometric formulation of differential equations, Harrison and Estabrook proposed a geometric approach for the symmetries of differential equations. In this Letter, we extend Harrison and Estabrook's approach to analyze the symmetries of differential-difference equations. The discrete exterior differential technique is applied in our approach. The Lie symmetry of (2+1)-dimensional Toda equation is investigated by means of our approach

ACT-R/E: An Embodied Cognitive Architecture for Human-Robot Interaction

Science.gov (United States)

2013-01-01

Threaded Cognition: An Integrated Theory of Concurrent Multitasking . Psychological Review, 115(1), 101–130, http://dx.doi.org/10.1037/0033-295X...Trafton, Naval Research Laboratory, Washington, DC, USA Email : greg.trafton@nrl.navy.mil Laura Hiatt, Naval Research Laboratory, Washington, DC, USA Email ...laura.hiatt@nrl.navy.mil Anthony Harrison, Naval Research Laboratory, Washington, DC, USA Email : anthony.harrison@nrl.navy.mil Frank Tamborello, Naval

Marine Geophysics: a Navy Symposium

Science.gov (United States)

1987-09-01

Harrison The Source of Marine Magnetic Anomalies Christopher GA. Harrison • 52 Principles of Operation and Applications of RF-driven SQUID Magnetometers... ink recorder, and thereby obtained detailed data over the limited range in which Layer 2 appeared as a first arrival. Those researchers who waited to... Extract from MPL [Marine Physical Laboratory of the Scripps Institution of Oceanography] Quarterly Reports, 1 April to 30 June 1949, by R. W. Raitt

Beyond Kotters Leading Change: A Broad Perspective on Organizational Change for Senior U.S. Military Leaders

Science.gov (United States)

2015-07-16

Defense Health Agency) and financial management (institution of the Defense Finance and Accounting System). o At the service level , this view sees...Chapter 5, “Ethical Dilemmas and Value Guidelines” (pp. 77-98). 58 Harrison , 18. 59 Harrison , 18. 60 Lippitt & Lippitt, 97. 61 Ian Hodder, “The...senior service college and enter the military bureaucracy at senior levels , they often enter environments where Kotter’s eight steps are difficult to

Voluntarist theology and early-modern science: The matter of the divine power, absolute and ordained.

Science.gov (United States)

Oakley, Francis

2018-03-01

This paper is an intervention in the debate inaugurated by Peter Harrison in 2002 when he called into question the validity of what has come to be called 'the voluntarism and early-modern science thesis'. Though it subsequently drew support from such historians of science as J. E. McGuire, Margaret Osler, and Betty-Joe Teeter Dobbs, the origins of the thesis are usually traced back to articles published in 1934 and 1961 respectively by the philosopher Michael Foster and the historian of ideas Francis Oakley. Central to Harrison's critique of the thesis are claims he made about the meaning of the scholastic distinction between the potentia dei absoluta et ordinata and the role it played in the thinking of early-modern theologians and natural philosophers. This paper calls directly into question the accuracy of Harrison's claims on that very matter.

Transitions Towards Operational Space-Based Ocean Observations: From Single Research Missions into Series and Constellations

Science.gov (United States)

2011-02-16

have formed the basis of sea ice concentration monitoring over last decades (see Breivik ct al. [20]). As for SST it is importance to secure the...J., Harrison D.E. and Stammer, D.. Eds., ESA Publication WPP- 306, 2010. 12 Gulev, S. Josey. S., Bourassa, M., Breivik , L.-A., Cronin M., Fairall...Harrison D.E. and Stammer, D., Eds., ESA Publication WPP-306, 2010. 20 Breivik , L.-A.. Carrieres, T., Eastwood, S., Fleming, A., Girard-Ardhuin, F

Specification of Scientific Tasks in Collaboration between Science, Industry and State, and Impact of Political Factors on Managerial Levers and Economy

Directory of Open Access Journals (Sweden)

Bondarenko Tetiana M.

2016-11-01

Full Text Available The issue of collaboration between science, industry and state is of relevance in domestic and international practice. In leading countries of the world and in Ukraine compatible production and scientific complexes are created; collaboration between research institutions and state is established, in particular the theory and practice of collaboration between science, industry and state on the basis of Triple Helix Model is widespread in the world; in scientific papers objects of research of economic processes, subjects of research of the economic theory are considered. However, there are no works where the objects and tasks of economic researches are studied on the basis of macroeconomic environment, and a distinct principle to distinguish research objects relating to different economies and types of production is laid out; scientific and practical problems of economy in the field of collaboration between state, science and industry are clearly defined. According to the purpose of the article (to specify scientific and practical tasks to rationalize scientific research, the experience gained is systematized and a scheme-matrix of scientific and practical problems is proposed. In scientific practice there are works highlighting principles of scientific research work, research tasks in the field of economy, scientific problems of economy but there are no works considering both principles and tasks of collaboration of academic economists with state and industry in order to provide scientists with recommendations on optimization of economic processes to improve the economic efficiency. Taking into account the experience gained, principles of collaboration of academic economists with the state and industry are identified. On the basis of the developed matrix of scientific and practical tasks, the principle of impact of political factors on managerial levers, the level of Gross Domestic Product and Gross Social Product is demonstrated.

Autoshaping in micrencephalic rats

International Nuclear Information System (INIS)

Goldstein, L.H.; Oakley, D.A.

1989-01-01

An autoshaping procedure in which the illumination of a lever was predictive of food reinforcement was used to compare learning in rats with micrencephaly induced by irradiation on the 16th day of gestation and in sham-irradiated controls. Both groups showed equivalent levels of lever-directed activity, and the micrencephalic animals differentiated as well as the control animals between the predictive lever and a nonpredictive lever. The micrencephalic animals were able to redistribute their lever-directed activity when the significance of the levers was reversed and did so more readily than the control animals. Results support the claim that association learning survives either traumatic or developmental neocortical damage and have implications for remedial procedures following both head injury and developmental cerebral pathology in humans

Autoshaping in micrencephalic rats.

Science.gov (United States)

Goldstein, L H; Oakley, D A

1989-06-01

An autoshaping procedure in which the illumination of a lever was predictive of food reinforcement was used to compare learning in rats with micrencephaly induced by irradiation on the 16th day of gestation and in sham-irradiated controls. Both groups showed equivalent levels of lever-directed activity, and the micrencephalic animals differentiated as well as the control animals between the predictive lever and a nonpredictive lever. The micrencephalic animals were able to redistribute their lever-directed activity when the significance of the levers was reversed and did so more readily than the control animals. Results support the claim that association learning survives either traumatic or developmental neocortical damage and have implications for remedial procedures following both head injury and developmental cerebral pathology in humans.

Inflation and large scale structure formation after COBE

International Nuclear Information System (INIS)

Schaefer, R.K.; Shafi, Q.

1992-06-01

The simplest realizations of the new inflationary scenario typically give rise to primordial density fluctuations which deviate logarithmically from the scale free Harrison-Zeldovich spectrum. We consider a number of such examples and, in each case we normalize the amplitude of the fluctuations with the recent COBE measurement of the microwave background anisotropy. The predictions for the bulk velocities as well as anisotropies on smaller (1-2 degrees) angular scales are compared with the Harrison-Zeldovich case. Deviations from the latter range from a few to about 15 percent. We also estimate the redshift beyond which the quasars would not be expected to be seen. The inflationary quasar cutoff redshifts can vary by as much as 25% from the Harrison-Zeldovich case. We find that the inflationary scenario provides a good starting point for a theory of large scale structure in the universe provided the dark matter is a combination of cold plus (10-30%) hot components. (author). 27 refs, 1 fig., 1 tab

Techniques for establishing schedules with wheel running as reinforcement in rats.

Science.gov (United States)

Iversen, I H

1993-07-01

In three experiments, access to wheel running was contingent on lever pressing. In each experiment, the duration of access to running was reduced gradually to 4, 5, or 6 s, and the schedule parameters were expanded gradually. The sessions lasted 2 hr. In Experiment 1, a fixed-ratio 20 schedule controlled a typical break-and-run pattern of lever pressing that was maintained throughout the session for 3 rats. In Experiment 2, a fixed-interval schedule of 6 min maintained lever pressing throughout the session for 3 rats, and for 1 rat, the rate of lever pressing was positively accelerated between reinforcements. In Experiment 3, a variable-ratio schedule of 20 or 35 was in effect and maintained lever pressing at a very stable pace throughout the session for 2 of 3 rats; for 1 rat, lever pressing was maintained at an irregular rate. When the session duration was extended to successive 24-hr periods, with food and water accessible in Experiment 3, lever pressing settled into a periodic pattern occurring at a high rate at approximately the same time each day. In each experiment, the rats that developed the highest local rates of running during wheel access also maintained the most stable and highest rates of lever pressing.

f-Ratios calculated with and without urea uptake in nitrogen uptake by phytoplankton

Digital Repository Service at National Institute of Oceanography (India)

Wafar, M.V.M.; Corre, P.L.; L'Helguen, S.

. Peterson (1979) Particulate organic matter Hux and planktonic new production in the deep ocean. Nature, 282,677-6X0. Epplcy R. W., .I. H. Sharp, E. H. Renger, M. J. Perry and W. G. Harrison (1977) Nitrogen assimilation by phytoplankton and other... f’rogress Serres. 67, 275-2X3. Harrison W. G.. I_. R. Harris, D. M. Karl. G. A. Knauer and D. G. Redaljc (1992) Nitrogen dynamics at the Vcrtcx time-series site. DeepSea Revearch. 39, 1.535-1557. Harvey W. A. and J. Caperon (1976) The rate...

Functional states of rat cortical circuits during the unpredictable availability of a reward-related cue.

Science.gov (United States)

Fernández-Lamo, Iván; Sánchez-Campusano, Raudel; Gruart, Agnès; Delgado-García, José M

2016-11-21

Proper performance of acquired abilities can be disturbed by the unexpected occurrence of external changes. Rats trained with an operant conditioning task (to press a lever in order to obtain a food pellet) using a fixed-ratio (1:1) schedule were subsequently placed in a Skinner box in which the lever could be removed randomly. Field postsynaptic potentials (fPSPs) were chronically evoked in perforant pathway-hippocampal CA1 (PP-CA1), CA1-subiculum (CA1-SUB), CA1-medial prefrontal cortex (CA1-mPFC), mPFC-nucleus accumbens (mPFC-NAc), and mPFC-basolateral amygdala (mPFC-BLA) synapses during lever IN and lever OUT situations. While lever presses were accompanied by a significant increase in fPSP slopes at the five synapses, the unpredictable absence of the lever were accompanied by decreased fPSP slopes in all, except PP-CA1 synapses. Spectral analysis of local field potentials (LFPs) recorded when the animal approached the corresponding area in the lever OUT situation presented lower spectral powers than during lever IN occasions for all recording sites, apart from CA1. Thus, the unpredictable availability of a reward-related cue modified the activity of cortical and subcortical areas related with the acquisition of operant learning tasks, suggesting an immediate functional reorganization of these neural circuits to address the changed situation and to modify ongoing behaviors accordingly.

Imaging after lever transplatation

International Nuclear Information System (INIS)

Turetschek, K.; Schober, E.; Dock, W.; Mostbeck, G.

1997-01-01

Introduction: Orthotopic liver transplantation (OLT) has become an accepted treatment for endstage liver disease. However, postoperative complications result in significant patient morbidity and mortality. Early detection and treatment of these complications is therefore of utmost importance. Materials and methods: We retrospectively reviewed the postoperative complications of the patients who underwent OLT at our institution. Duplex Doppler sonography and cholangiography were the primary imaging modalities in postoperative evaluation of the transplanted liver. Other important techniques were CT, MRI, and angiography, which may contribute to a reliable diagnosis of vascular or biliary complications. Results: Second to primary organ dysfunction, vascular complications are the most frequent cause of graft loss. Thrombosis of the hepatic artery is the most common and most serious vascular complication, with a reported incidence from 4 to 42%. Bile duct sludge, leaks and strictures are frequent complications after liver transplantation, which can contribute to graft dysfunction. Biliary tract complications usually occur within the first 3 months and require interventional radiological or surgical therapy. Since liver transplant recipients undergo immunosuppressive therapy, they are at increased risk of developing late post-transplant malignancies, which are best depicted by US, CT or MRI. However, radiological diagnosis of lymphoproliferative disorder has to be confirmed by liver biopsy. Conclusion: Cholangiography and Duplex sonography are routinely used in the postoperative evaluation of patients with OLT. CT, MRI, and angiography are problem-solving tools in equivocal cases. (orig.) [de

Creating levers of management

DEFF Research Database (Denmark)

Nielsen, Christian; Sort, Jesper Chrautwald; Bentsen, Martin Juul

This paper reports a longitudinal multi-case research project encompassing 72 semi-structured interviews carried out in 2011 and 2012. The interviews covered topics of the collaboration type, the initiation of the collaboration and details concerning the planning of the collaborations. In additio...

Transport as economical lever

International Nuclear Information System (INIS)

Laurelut, J.

2007-01-01

In a changing European market, GRTgaz company is in charge of the double mission of supplying natural gas to the end user in optimal cost and security conditions, and also of accompanying the opening of the gas market in France by making the necessary arrangements for a non-discriminatory access of the network to all granted suppliers. GRTgaz, daughter company of Gaz de France group and in charge of gas transport, has laid down the goal to develop its supply capacity thanks to an ambitious program of investment for the 10 years to come. Beside the advantage of allowing the end user to chose his gas supplier, these investments offer the opportunity of improving the safety of facilities and of reducing their environmental impact. This article presents an interview of J. Laurelut, general director of GRTgaz, who explains the 10 years development plan of his company. (J.S.)

Parallel learning in an autoshaping paradigm.

Science.gov (United States)

Naeem, Maliha; White, Norman M

2016-08-01

In an autoshaping task, a single conditioned stimulus (CS; lever insertion) was repeatedly followed by the delivery of an unconditioned stimulus (US; food pellet into an adjacent food magazine) irrespective of the rats' behavior. After repeated training trials, some rats responded to the onset of the CS by approaching and pressing the lever (sign-trackers). Lesions of dorsolateral striatum almost completely eliminated responding to the lever CS while facilitating responding to the food magazine (US). Lesions of the dorsomedial striatum attenuated but did not eliminate responding to the lever CS. Lesions of the basolateral or central nucleus of the amygdala had no significant effects on sign-tracking, but combined lesions of the 2 structures impaired sign-tracking by significantly increasing latency to the first lever press without affecting the number of lever presses. Lesions of the dorsal hippocampus had no effect on any of the behavioral measures. The findings suggest that sign-tracking with a single lever insertion as the CS may consist of 2 separate behaviors learned in parallel: An amygdala-mediated conditioned orienting and approach response and a dorsal striatum-mediated instrumental response. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Is induction produced by upcoming food-pellet reinforcement the outcome of an increase in overall activity or in operant responding?

Science.gov (United States)

Weatherly, Jeffrey N; Arthur, Emily I L; Nurnberger, Jeri T

2006-01-01

Researchers have demonstrated that rats reliably increase their rates of pressing a lever for 1% liquid-sucrose reinforcement if they will soon have the opportunity to press a lever for food-pellet reinforcement. In the present experiments, the authors investigated if this increase in response rates occurred because the upcoming food pellets produced an increase in all behaviors (i.e., general arousal) or an increase in only the specific operant response (i.e., lever pressing). The results of Experiments 1 and 2 showed that the appearance of induction in rats' lever pressing for 1% sucrose reinforcement when food-pellet reinforcement was upcoming did not coincide with increases in the frequency of running in a wheel or making a nonreinforced nose-poke response. On the other hand, in Experiment 3, the authors found the appearance of induction coincided with increase nonreinforced lever presses on an adjacent lever. These results shed doubt on the idea that induction is a result of a general increase in all activity, and suggest instead that the increase in responding that occurs during induction is limited to the operant response.

Stimulus- and response-reinforcer contingencies in autoshaping, operant, classical, and omission training procedures in rats.

Science.gov (United States)

Atnip, G W

1977-07-01

Separate groups of rats received 500 trials of lever-press training under autoshaping (food delivery followed 10-second lever presentations, or occurred immediately following a response); operant conditioning (responding was necessary for food delivery); and classical conditioning (food followed lever presentations regardless of responding). Each group then received 500 trials on an omission procedure in which food was omitted on trials with a response. Another group received 1000 trials on the omission procedure, and a fifth group, random control, received 1000 uncorrelated presentations of lever and food. The autoshaping, operant, and classical groups reached high response levels by the end of initial training. Acquisition was fastest in the autoshaping group. Responding remained consistently low in the control group. The omission group responded at a level between the control group and the other three groups. During omission training, responding in these three groups declined to the omission-group level. During omission training, the rats continued contacting the lever frequently after lever pressing had declined. Response maintenance under omission training seems not to require topographic similarity between the response and reinforcer-elicited consummatory behaviors.

DCS Survey Submission for Harrison County, IA

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — Survey data includes spatial datasets and data tables necessary to digitally represent data collected in the survey phase of the study. (Source: FEMA Guidelines and...

Assessment of hydrology, water quality, and trace elements in selected placer-mined creeks in the birch creek watershed near central, Alaska, 2001-05

Science.gov (United States)

Kennedy, Ben W.; Langley, Dustin E.

2007-01-01

Executive Summary The U.S. Geological Survey, in cooperation with the Bureau of Land Management, completed an assessment of hydrology, water quality, and trace-element concentrations in streambed sediment of the upper Birch Creek watershed near Central, Alaska. The assessment covered one site on upper Birch Creek and paired sites, upstream and downstream from mined areas, on Frying Pan Creek and Harrison Creek. Stream-discharge and suspended-sediment concentration data collected at other selected mined and unmined sites helped characterize conditions in the upper Birch Creek watershed. The purpose of the project was to provide the Bureau of Land Management with baseline information to evaluate watershed water quality and plan reclamation efforts. Data collection began in September 2001 and ended in September 2005. There were substantial geomorphic disturbances in the stream channel and flood plain along several miles of Harrison Creek. Placer mining has physically altered the natural stream channel morphology and removed streamside vegetation. There has been little or no effort to re-contour waste rock piles. During high-flow events, the abandoned placer-mine areas on Harrison Creek will likely contribute large quantities of sediment downstream unless the mined areas are reclaimed. During 2004 and 2005, no substantial changes in nutrient or major-ion concentrations were detected in water samples collected upstream from mined areas compared with water samples collected downstream from mined areas on Frying Pan Creek and Harrison Creek that could not be attributed to natural variation. This also was true for dissolved oxygen, pH, and specific conductance-a measure of total dissolved solids. Sample sites downstream from mined areas on Harrison Creek and Frying Pan Creek had higher median suspended-sediment concentrations, by a few milligrams per liter, than respective upstream sites. However, it is difficult to attach much importance to the small downstream increase

77 FR 16315 - Indiana Disaster #IN-00041

Science.gov (United States)

2012-03-20

..., Harrison, Jackson, Jennings, Lawrence, Ohio, Orange, Pike, Spencer, Switzerland, Vanderburgh. Kentucky: Carroll, Daviess, Henderson, Jefferson, Oldham, Trimble. The Interest Rates are: Percent For Physical...

Effects of Haloperidol on Responding Maintained with Food and Sucrose-Water

Directory of Open Access Journals (Sweden)

Carlos F. Aparicio

2010-02-01

Full Text Available The “hedonic” value of reinforcers is mediated by dopamine. Accordingly,haloperidol diminishes the value of reinforcers, by interfering with the emission of operant behaviors. Alternatively, the interference of dopamine transmission does not prevent animals from eating food. Thus, reinforcers remain intact after the administration of haloperidol. We assessed these possibilities with eight Wistar rats and two types of reinforcers, food-pellets and sucrose-water, delivered under multiple reinforcement schedules. Ingeneral, lever presses maintained by food-pellets were higher than those maintained by sucrose-water. Haloperidol produced dose-related decreases in lever presses and obtained reinforcers. Different doses had no effect on the number of lever presses. Subcutaneous administrations of haloperidol produced higher decreases in lever presses than intra-peritoneal administrations. Decreases in lever pressing were not necessarily accompanied by substantial reductions in obtained food-pellets and sucrose-water reinforcers; underthe effects of haloperidol rats continued to produce a considerable number of both types of reinforcers.

Flexural Stiffness of Myosin Va Subdomains as Measured from Tethered Particle Motion

Science.gov (United States)

Michalek, Arthur J.; Kennedy, Guy G.; Warshaw, David M.; Ali, M. Yusuf

2015-01-01

Myosin Va (MyoVa) is a processive molecular motor involved in intracellular cargo transport on the actin cytoskeleton. The motor's processivity and ability to navigate actin intersections are believed to be governed by the stiffness of various parts of the motor's structure. Specifically, changes in calcium may regulate motor processivity by altering the motor's lever arm stiffness and thus its interhead communication. In order to measure the flexural stiffness of MyoVa subdomains, we use tethered particle microscopy, which relates the Brownian motion of fluorescent quantum dots, which are attached to various single- and double-headed MyoVa constructs bound to actin in rigor, to the motor's flexural stiffness. Based on these measurements, the MyoVa lever arm and coiled-coil rod domain have comparable flexural stiffness (0.034 pN/nm). Upon addition of calcium, the lever arm stiffness is reduced 40% as a result of calmodulins potentially dissociating from the lever arm. In addition, the flexural stiffness of the full-length MyoVa construct is an order of magnitude less stiff than both a single lever arm and the coiled-coil rod. This suggests that the MyoVa lever arm-rod junction provides a flexible hinge that would allow the motor to maneuver cargo through the complex intracellular actin network. PMID:26770194

The role of the lateral habenula in punishment.

Science.gov (United States)

Jean-Richard Dit Bressel, Philip; McNally, Gavan P

2014-01-01

The lateral habenula (LHb) is a small epithalamic structure that projects via the fasciculus retroflexus to the midbrain. The LHb is known to modulate midbrain dopamine (DA) neurons, including inhibition of ventral tegmental area (VTA) neurons via glutamatergic excitation of the GABAergic rostromedial tegmental nucleus (RMTg). A variety of lines of evidence show activity in LHb and the LHb-RMTg pathway is correlated with, and is sufficient to support, punishment learning. However, it is not immediately clear whether LHb is necessary for punishment. Here we used a within-subjects punishment task to assess the role of LHb in the acquisition and expression of punishment as well as in aversive choice. Rats that pressed two individually presented levers for pellet rewards rapidly suppressed responding to one lever if it also caused footshock deliveries (punished lever) but continued pressing a second lever that did not cause footshock (unpunished lever). Infusions of an AMPA receptor antagonist (NBQX) into LHb had no effect on the acquisition or expression of this punishment, or on aversive choice, but did increase locomotion. Infusion of the sodium channel blocker bupivacaine likewise had no effect on expression of punishment. However, infusion of the calcium channel blocker mibefradil did affect expression of punishment by significantly decreasing the latency with which rats responded on the punished lever and significantly increasing unpunished lever-pressing. Taken together, these findings indicate that the LHb plays a limited role in punishment, influencing only latency to respond. This role is linked to calcium channel permeability and not AMPA receptor or sodium channel permeability.

The effects of varied extinction procedures on contingent cue-induced reinstatement in Sprague-Dawley rats.

Science.gov (United States)

Buffalari, Deanne M; Feltenstein, Matthew W; See, Ronald E

2013-11-01

Cue exposure therapy, which attempts to limit relapse by reducing reactivity to cocaine-paired cues through repeated exposures, has had limited success. The current experiments examined cocaine cue-induced anxiogenesis and investigated whether a model of cue exposure therapy would reduce reinstatement of cocaine seeking in rats with a history of cocaine self-administration. Male rats experienced daily intravenous cocaine self-administration. Rats then experienced exposure to either the self-administration context or the context plus noncontingent presentations of cocaine-paired cues. Immediately following exposure, anxiety-like behavior was measured using elevated plus maze and defensive burying tests. In a second group of rats, self-administration was followed by 7 days of exposure to the context, context + noncontingent cue exposure, lever extinction, or cue + lever extinction. All animals then underwent two contingent cue-induced reinstatement tests separated by 7 days of lever extinction. Exposure to noncontingent cocaine-paired cues in the self-administration context increased anxiety-like behavior on the defensive burying test. Animals that experienced lever + cue extinction displayed the least cocaine seeking on the first reinstatement test, and lever extinction reduced cocaine seeking below context exposure or context + noncontingent cue exposure. All animals had similar levels of cocaine seeking on the second reinstatement test. Noncontingent cue exposure causes anxiety, and noncontingent cue and context exposure are less effective at reducing contingent cue-induced reinstatement than lever or lever + cue extinction. These data indicate that active extinction of the drug-taking response may be critical for reduction of relapse proclivity in former cocaine users.

Stirling engine power control and motion conversion mechanism

Science.gov (United States)

Marks, David T.

1983-01-01

A motion conversion device for converting between the reciprocating motion of the pistons in a Stirling engine and the rotating motion of its output shaft, and for changing the stroke and phase of the pistons, includes a lever pivoted at one end and having a cam follower at the other end. The piston rod engages the lever intermediate its ends and the cam follower engages a cam keyed to the output shaft. The lever pivot can be moved to change the length of the moment arm defined between the cam follower and the piston rod the change the piston stroke and force exerted on the cam, and the levers can be moved in opposite directions to change the phase between pistons.

Indiana protiv KGB / Anna Fedina, Pjotr Obraztsov

Index Scriptorium Estoniae

Fedina, Anna

2008-01-01

Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008

Superkangelase neljas tulemine / Signe Sillasoo

Index Scriptorium Estoniae

Sillasoo, Signe

2008-01-01

Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008

Sangari naasmine / Jaanus Noormets

Index Scriptorium Estoniae

Noormets, Jaanus

2008-01-01

Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008

Vana ja tuttav, aga liiga turvaline / Alar Niineväli

Index Scriptorium Estoniae

Niineväli, Alar

2008-01-01

Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008

Nad avantjuristom godõ ne vlastnõ / Boris Tuch

Index Scriptorium Estoniae

Tuch, Boris, 1946-

2008-01-01

Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008

X-Files kohtub Indy'ga / Rivo Sarapik

Index Scriptorium Estoniae

Sarapik, Rivo, 1981-

2008-01-01

Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008

Koltunud Indiana Jones / Kutt Kommel

Index Scriptorium Estoniae

Kommel, Kutt

2008-01-01

Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008

Indiana Jones ja kristallpealuu kuningriik / Jaanus Noormets

Index Scriptorium Estoniae

Noormets, Jaanus

2008-01-01

Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008

Mis te Indyga teete?

Index Scriptorium Estoniae

2008-01-01

Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008

"Salatoimikud" Indiana Jonesi moodi / Inna-Katrin Hein

Index Scriptorium Estoniae

Hein, Inna-Katrin

2008-01-01

Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008

Väike psühhoanalüüs Indiana Jonesile / Aarne Ruben

Index Scriptorium Estoniae

Ruben, Aarne, 1971-

2008-01-01

Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008

Increased sign-tracking behavior in adolescent rats.

Science.gov (United States)

DeAngeli, Nicole E; Miller, Sarah B; Meyer, Heidi C; Bucci, David J

2017-11-01

An autoshaping procedure was used to test the notion that conditioned stimuli (CSs) gain greater incentive salience during adolescence than young adulthood under conditions of social isolation rearing and food restriction. Rats were single-housed and placed on food restriction during 10 daily training sessions in which a lever (CS + ) was presented then followed immediately by a food unconditioned stimulus (US). A second lever (CS - ) was presented on intermixed trials and was not reinforced. Despite the fact that food delivery was not contingent on the rats' behavior, all rats exhibited behaviors directed towards the lever (i.e., sign-tracking). In the adolescent group, the rate of lever pressing and the percentage of trials with a lever press were higher than in young adults. Initially, group differences were observed when rats were retrained when the adolescents had reached young adulthood. These findings support the hypothesis that cues that come to predict reward become imbued with excessive motivational value in adolescents, perhaps contributing to the hyper-responsiveness to reward-related stimuli typically observed during this period of development. © 2017 Wiley Periodicals, Inc.

ORIGINAL ARTICLES

African Journals Online (AJOL)

. PARTNERSHIPS FOR STD. CONTROL IN SOUTH AFRICA-. PERSPECTIVES FROM THE. HLABISA EXPERIENCE. David Wilkinson, Salim S Abdool Karim, Mark Lurie,. Abigail Harrison. Sexually transmitted diseases (STDs) are epidemic in.

78 FR 21515 - Prevailing Rate Systems; Redefinition of the St. Louis, MO; Southern Missouri; Cleveland, OH; and...

Science.gov (United States)

2013-04-11

... have a significant economic impact on a substantial number of small entities because they will affect... Beaver Butler Washington Westmoreland Area of Application. Survey area plus: Ohio: Belmont Harrison...

Recovery of Pavlovian sign-tracking (autoshaping) following the discontinuation of inter-trial interval food in rats.

Science.gov (United States)

Kearns, David N; Weiss, Stanley J

2007-07-01

In pigeons, Pavlovian autoshaped keypecking produced by keylight-food pairings has been eliminated by introducing food during periods between CS presentations (i.e., during the inter-trial intervals). Keypecking eliminated in this manner reappears when the inter-trial USs are discontinued even though the CS is no longer paired with US. The present experiment investigated whether this recovery of responding produced by discontinuing unpaired inter-trial US presentations could be extended to another species, rats, within a Pavlovian sign-tracking paradigm. Rats were initially trained on a procedure where insertion of one retractable lever (CS(+)) was followed, response independently, with food, while insertion of another lever (CS(-)) was not paired with food. Rats quickly came to contact the CS(+) lever at high rates, but contacted the CS(-) lever infrequently. In the next phase, CS(+) was no longer followed by food. Explicitly unpaired food was presented only during the inter-trial intervals when both levers were absent. This treatment essentially eliminated the sign-tracking response. In the final phase, the unpaired inter-trial food presentations were discontinued while both CSs continued to be presented without food. This produced a significant recovery of the sign-tracking elicited by the CS(+) lever, extending the species generality of the Pavlovian resurgence phenomenon that has previously only been reported in pigeons, to rats.

An analysis of policy success and failure in formal evaluations of Australia's national mental health strategy (1992-2012).

Science.gov (United States)

Grace, Francesca C; Meurk, Carla S; Head, Brian W; Hall, Wayne D; Harris, Meredith G; Whiteford, Harvey A

2017-05-30

Heightened fiscal constraints, increases in the chronic disease burden and in consumer expectations are among several factors contributing to the global interest in evidence-informed health policy. The present article builds on previous work that explored how the Australian Federal Government applied five instruments of policy, or policy levers, to implement a series of reforms under the Australian National Mental Health Strategy (NMHS). The present article draws on theoretical insights from political science to analyse the relative successes and failures of these levers, as portrayed in formal government evaluations of the NMHS. Documentary analysis of six evaluation documents corresponding to three National Mental Health Plans was undertaken. Both the content and approach of these government-funded, independently conducted evaluations were appraised. An overall improvement was apparent in the development and application of policy levers over time. However, this finding should be interpreted with caution due to variations in evaluation approach according to Plan and policy lever. Tabulated summaries of the success and failure of each policy initiative, ordered by lever type, are provided to establish a resource that could be consulted for future policy-making. This analysis highlights the complexities of health service reform and underscores the limitations of narrowly focused empirical approaches. A theoretical framework is provided that could inform the evaluation and targeted selection of appropriate policy levers in mental health.

The Relationship of Temperature to Strength and Power Production in Intact Human Skeletal Muscle.

Science.gov (United States)

1979-06-01

newton- meters (Nm). The use of the Cybex II isokinetic device has been similarly described by Thorstensson et al. (1976). The peak torque value, or the... isokinetic testing device at four lever arm speeds (0,60,180 and 300*/sec).Maximal knee exter- sions at the different lever arm speeds were evaluated for...Each subject was tested on the Cybex II isokinetic testing device at four lever arm speeds (0,60,180 and $Osec).Maximal knee exten- sions at the

76 FR 11460 - Product Cancellation Order for Certain Pesticide Registrations

Science.gov (United States)

2011-03-02

... with Preemergent Weed Control. 044446-00053 Kill A Bug II Insect Spray.. Phenothrin 044446-00066 Aero Roach & Ant Insecticide Phenothrin 045188-00002 Harrison Flea and Tick Piperonyl butoxide Shampoo for...

77 FR 54600 - Ohio; Major Disaster and Related Determinations

Science.gov (United States)

2012-09-05

... authority vested in the Administrator, under Executive Order 12148, as amended, W. Michael Moore, of FEMA is..., Harrison, Highland, Hocking, Jackson, Knox, Lawrence, Licking, Logan, Meigs, Miami, Monroe, Morgan, Morrow...

1 PERSPECTIVES In Memoriam: Richard (Rick) G. Harrison ...

Indian Academy of Sciences (India)

Navya

2016-05-06

May 6, 2016 ... 2016, but the impact of his work will not soon be lost for the people with ... through the creation of unnecessary jargon by stating, “…old ... extremely limited direct observations to infer his love of family, but I am going to risk.

1 PERSPECTIVES In Memoriam: Richard (Rick) G. Harrison ...

Indian Academy of Sciences (India)

Navya

2016-05-06

May 6, 2016 ... 2016, but the impact of his work will not soon be lost for the people with ... benefit for our research program was that Rick's careful synthesis of the literature in this ... in his sphere of influence, and his obvious love for family.

75 FR 66756 - Environmental Impacts Statements; Notice of Availability

Science.gov (United States)

2010-10-29

..., Expansion of Existing South Hallsville No. 1 Mine. Issuance of Section 404 Permit, Rusk, Harrison and Panola...-2375. EIS No. 20100427, Final EIS, NASA, VA, Wallops Flight Facility, Shoreline Restoration and...

Autoshaping, random control, and omission training in the rat.

Science.gov (United States)

Locurto, C; Terrace, H S; Gibbon, J

1976-11-01

The role of the stimulus-reinforcer contingency in the development and maintenance of lever contact responding was studied in hooded rats. In Experiment I, three groups of experimentally naive rats were trained either on autoshaping, omission training, or a random-control procedure. Subjects trained by the autoshaping procedure responded more consistently than did either random-control or omission-trained subjects. The probability of at least one lever contact per trial was slightly higher in subjects trained by the omission procedure than by the random-control procedure. However, these differences were not maintained during extended training, nor were they evident in total lever-contact frequencies. When omission and random-control subjects were switched to the autoshaping condition, lever contacts increased in all animals, but a pronounced retardation was observed in omission subjects relative to the random-control subjects. In addition, subjects originally exposed to the random-control procedure, and later switched to autoshaping, acquired more rapidly than naive subjects that were exposed only on the autoshaping procedure. In Experiment II, subjects originally trained by an autoshaping procedure were exposed either to an omission, a random-control, or an extinction procedure. No differences were observed among the groups either in the rate at which lever contacts decreased or in the frequency of lever contacts at the end of training. These data implicate prior experience in the interpretation of omission-training effects and suggest limitations in the influence of stimulus-reinforcer relations in autoshaping.

Autoshaping, random control, and omission training in the rat1

Science.gov (United States)

Locurto, Charles; Terrace, H. S.; Gibbon, John

1976-01-01

The role of the stimulus-reinforcer contingency in the development and maintenance of lever contact responding was studied in hooded rats. In Experiment I, three groups of experimentally naive rats were trained either on autoshaping, omission training, or a random-control procedure. Subjects trained by the autoshaping procedure responded more consistently than did either random-control or omission-trained subjects. The probability of at least one lever contact per trial was slightly higher in subjects trained by the omission procedure than by the random-control procedure. However, these differences were not maintained during extended training, nor were they evident in total lever-contact frequencies. When omission and random-control subjects were switched to the autoshaping condition, lever contacts increased in all animals, but a pronounced retardation was observed in omission subjects relative to the random-control subjects. In addition, subjects originally exposed to the random-control procedure, and later switched to autoshaping, acquired more rapidly than naive subjects that were exposed only on the autoshaping procedure. In Experiment II, subjects originally trained by an autoshaping procedure were exposed either to an omission, a random-control, or an extinction procedure. No differences were observed among the groups either in the rate at which lever contacts decreased or in the frequency of lever contacts at the end of training. These data implicate prior experience in the interpretation of omission-training effects and suggest limitations in the influence of stimulus-reinforcer relations in autoshaping. PMID:16811960

The gearing function of running shoe longitudinal bending stiffness.

Science.gov (United States)

Willwacher, Steffen; König, Manuel; Braunstein, Björn; Goldmann, Jan-Peter; Brüggemann, Gert-Peter

2014-07-01

The purpose of the present study was to investigate whether altered longitudinal bending stiffness (LBS) levels of the midsole of a running shoe lead to a systematic change in lower extremity joint lever arms of the ground reaction force (GRF). Joint moments and GRF lever arms in the sagittal plane were determined from 19 male subjects running at 3.5 m/s using inverse dynamics procedures. LBS was manipulated using carbon fiber insoles of 1.9 mm and 3.2 mm thickness. Increasing LBS led to a significant shift of joint lever arms to a more anterior position. Effects were more pronounced at distal joints. Ankle joint moments were not significantly increased in the presence of higher GRF lever arms when averaged over all subjects. Still, two individual strategies (1: increase ankle joint moments while keeping push-off times almost constant, 2: decrease ankle joint moments and increase push-off times) could be identified in response to increased ankle joint lever arms that might reflect individual differences between subjects with respect to strength capacities or anthropometric characteristics. The results of the present study indicate that LBS systematically influences GRF lever arms of lower extremity joints during the push-off phase in running. Further, individual responses to altered LBS levels could be identified that could aid in finding optimum LBS values for a given individual. Copyright © 2014 Elsevier B.V. All rights reserved.

Food deprivation enhances both autoshaping and autoshaping impairment by a latent inhibition procedure.

Science.gov (United States)

Sparber, S B; Bollweg, G L; Messing, R B

1991-02-01

The influence of food deprivation on acquisition of autoshaped operant behavior was measured. In one study separate groups of young, male rats that were deprived to 75%, 80%, 85%, 90%, and 95% of ad lib weight were subjected to an autoshaping procedure in which a 6 s delay was interposed between lever retraction (which occurred when rats made a lever touch, or automatically after 15 s) and food pellet delivery. In a second study, groups of rats were deprived to 80% or 90% of ad lib weight prior to testing in a latent inhibition variation of the same autoshaping procedure. This was done to determine if greater food deprivation would enhance learning which, because of the latent inhibition manipulation, is manifest as less lever-directed behavior. Greater food deprivation was associated both with fast acquisition of autoshaped lever responding and with more reliable failure to increase lever responding in the latent inhibition paradigm. Thus, increasing food deprivation was associated with enhanced acquisition regardless of whether the required performance was an increase or a failure to increase the same behavior, indicating a specific effect on learning. Copyright © 1991. Published by Elsevier B.V.

A coal combine

Energy Technology Data Exchange (ETDEWEB)

Wlachovsky, I; Bartos, J

1980-02-15

A design is presented for a coal combine, equipped with two drum operational units, on whose both ends of the upper surface of the body, two coal saws are mounted with the help of a lever system. These saws, found in an operational position, form a gap in the block of the coal block, which is not embraced by the drum operational unit. The coal block, found between the gap and the support, falls down onto the longwall scraper conveyor. The lever system of each coal saw is controlled by two hydraulic jacks. One of the jacks is mounted vertically on the facial wall of the body of the combine and is used for the hoisting for the required height of the horizontal arm of the lever, reinforced by one end in the hinge on the body of the combine. On the ''free'' end of that lever, a coal saw is mounted in a hinge-like fashion and which is connected by the hydraulic jack to the horizontal arm of the lever system. This hydraulic jack is used for the clamping of the coal saw to the face.

Cosmological data and indications for new physics

Energy Technology Data Exchange (ETDEWEB)

Benetti, Micol [Physics Department and ICRA, Università di Roma ' ' La Sapienza' ' , Ple. Aldo Moro 2, 00185, Rome (Italy); Gerbino, Martina; Melchiorri, Alessandro; Pagano, Luca [Physics Department and INFN, Università di Roma ' ' La Sapienza' ' , Ple Aldo Moro 2, 00185, Rome (Italy); Kinney, William H. [Department of Physics, University at Buffalo, the State University of New York, Buffalo, NY 14260-1500 (United States); Kolb, Edward W. [Department of Astronomy and Astrophysics, Enrico Fermi Institute, and Kavli Institute for Cosmological Physics, University of Chicago, Chicago, Illinois 60637-1433 (United States); Lattanzi, Massimiliano [Dipartimento di Fisica e Science della Terra, Università di Ferrara and INFN, sezione di Ferrara, Polo Scientifico e Tecnologico - Edificio C Via Saragat, 1, I-44122 Ferrara Italy (Italy); Riotto, Antonio, E-mail: micol.benetti@roma1.infn.it, E-mail: martina.gerbino@roma1.infn.it, E-mail: whkinney@buffalo.edu, E-mail: Rocky.Kolb@uchicago.edu, E-mail: lattanzi@fe.infn.it, E-mail: alessandro.melchiorri@roma1.infn.it, E-mail: luca.pagano@roma1.infn.it, E-mail: antonio.riotto@unige.ch [Department of Theoretical Physics and Center for Astroparticle Physics (CAP) 24 quai E. Ansermet, CH-1211 Geneva 4 (Switzerland)

2013-10-01

Data from the Atacama Cosmology Telescope (ACT) and the South Pole Telescope (SPT), combined with the nine-year data release from the WMAP satellite, provide very precise measurements of the cosmic microwave background (CMB) angular anisotropies down to very small angular scales. Augmented with measurements from Baryonic Acoustic Oscillations surveys and determinations of the Hubble constant, we investigate whether there are indications for new physics beyond a Harrison-Zel'dovich model for primordial perturbations and the standard number of relativistic degrees of freedom at primordial recombination. All combinations of datasets point to physics beyond the minimal Harrison-Zel'dovich model in the form of either a scalar spectral index different from unity or additional relativistic degrees of freedom at recombination (e.g., additional light neutrinos). Beyond that, the extended datasets including either ACT or SPT provide very different indications: while the extended-ACT (eACT) dataset is perfectly consistent with the predictions of standard slow-roll inflation, the extended-SPT (eSPT) dataset prefers a non-power-law scalar spectral index with a very large variation with scale of the spectral index. Both eACT and eSPT favor additional light degrees of freedom on top of the Harrison-Zel'dovich model. eACT is consistent with zero neutrino masses, while eSPT favors nonzero neutrino masses at more than 95% confidence.

Vastandlik paar valede võrgus

Index Scriptorium Estoniae

2000-01-01

Põnevusfilm "Pettuse võrgus" ("Random Hearts"), lühiandmed peaosaliste Harrison Fordi ja Kristin Scott Thomase, kirjaniku Warren Adleri ja režissöör Sydney Pollacki kohta. : Ameerika Ühendriigid 1999

Plaadid / Valner Valme

Index Scriptorium Estoniae

Valme, Valner, 1970-

2004-01-01

Uutest heliplaatidest Handsome Boy Modelling School "White People", Moron, Julies "Premium Par", Harrison, Joel "So Long 2nd Street", General Electrics "Cliquety Kliqk", Razorlight "Up All Night", Bob Marley & Wailers "127 King Street"

Attitudes, barriers and enablers to physical activity in pregnant women: a systematic review

Directory of Open Access Journals (Sweden)

Anne L Harrison

2018-01-01

Registration: PROSPERO CRD42016037643. [Harrison AL, Taylor NF, Shields N, Frawley HC (2018 Attitudes, barriers and enablers to physical activity in pregnant women: a systematic review. Journal of Physiotherapy 64: 24–32

Common Laundry Detergent Ingredient May Help Preserve Muscle Tissue After Severe Injury

Science.gov (United States)

... Yoo JJ, Harrison BS, Christ GJ. Oxygen Generating Biomaterials Preserve Skeletal Muscle Homeostasis under Hypoxic and Ischemic ... scientific news and resources on diseases of the bones, joints, muscles, and skin from the NIAMS. Click ...

A "Star Wars" Objector Lays His Research on the Line.

Science.gov (United States)

Tobias, Sheila

1987-01-01

For one optical scientist, Harrison Barrett, the decision not to accept funding for research related to the Strategic Defense Initiative has meant giving up a major part of his work in optical computing. (MSE)

Cough Culprits: What's the Difference Between Bronchitis and Pneumonia?

Science.gov (United States)

... bronchitis, it is usually mild (below 101 degrees Fahrenheit). In more serious cases, you may have chest ... 20892-2094 nihnewsinhealth@od.nih.gov Tel: 301-451-8224 Editor: Harrison Wein, Ph.D. Managing Editor: ...

Assessing hydroaeroponic culture for the tripartite symbiosis of ...

African Journals Online (AJOL)

Jane

2011-07-25

Jul 25, 2011 ... IRD-SupAgro, 2 place Viala, 34060 Montpellier Cedex, France. ... hydroaeroponic culture under sufficient versus deficient P supplies ..... Food. Agric. 1: 172-173. Harrison MJ (1998). Development of the arbuscular mycorrhizal.

Westerns i vildrede

DEFF Research Database (Denmark)

Bjerre, Thomas Ærvold

2013-01-01

Disney's "The Lone Ranger" er seneste bevis på, at westernfilmen stadig lever i Hollywood. Men hvor genren engang dominerede og satte dagsordenen, lever den i dag et mere risikabelt liv spændt ud mellem uslyldig underholdning og seriøs samfundsdebat...

Osteomyelitis - children

Science.gov (United States)

... 13th ed. Philadelphia, PA: Elsevier; 2017:chap 21. Kaplan SL. Osteomyelitis. In: Kliegman RM, Stanton BF, St. ... Krogstad P. Osteomyelitis. In: Cherry JD, Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ, eds. Feigin and ...

Interview of David Elliston Allen

OpenAIRE

Allen, David

2009-01-01

Interviewed on 12 April 1983 by Jack Goody and Alan Macfarlane and filmed and edited by Sarah Harrison. Made on old and low quality equipment. An interview of the historian and naturalist David Elliston Allen

Aed, imelise rahu paik / Merilen Mentaal

Index Scriptorium Estoniae

Mentaal, Merilen, 1972-

2008-01-01

Chelsea Flower Show 2008 võistelnud aedadest. Kujundajateks Philip Nash, Andy Sturgeon, Buono Gazerwitz, Trevor Tooth, Philip Nixon, Thomas Hoblyn, Robert Myers, Tom Stuart-Smith, Yvonne Innes ja Olivia Harrison. 11 värv. ill

Nostalgiline nagu soe tekk / Lauri Kaare

Index Scriptorium Estoniae

Kaare, Lauri

2008-01-01

22 mail esilinastub Steven Spielbergi järjekordne Indiana Jones'i film, kaasstsenaristiks ja produtsendiks George Lucas ja Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull")

Indiana Dzhons vozvrashtshajetsja / Melor Sturua

Index Scriptorium Estoniae

Sturua, Melor

2008-01-01

22 mail esilinastub Steven Spielbergi järjekordne Indiana Jones'i film, kaasstsenaristiks ja produtsendiks George Lucas ja Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull")

Beta-adrenoreceptor blockade abolishes atomoxetine-induced risk taking.

Science.gov (United States)

Yang, Fan Nils; Pan, Jing Samantha; Li, Xinwang

2016-01-01

Clinical studies have shown that patients with exaggerated risk-taking tendencies have high baseline levels of norepinephrine. In this work, we systemically manipulated norepinephrine levels in rats and studied their behavioral changes in a probabilistic discounting task, which is a paradigm for gauging risk taking. This study aims to explore the effects of the selective norepinephrine reuptake inhibitor (atomoxetine at doses of 0.6, 1.0 and 1.8 mg/kg), and receptor selective antagonists (propranolol at a single dose of 1.0/kg, and prazosin at a single dose of 0.1 mg/kg), on risk taking using a probabilistic discounting task. In this task, there were two levers available to rats: pressing the 'small/certain' lever guaranteed a single food pellet, and pressing the 'large/risky' lever yielded either four pellets or none. The probability of receiving four food pellets decreased across the four experimental blocks from 100% to 12.5%. Atomoxetine increased the tendency to choose the large/risky lever. It significantly reduced the lose-shift effect (i.e. pressing a different lever after losing a trial), but did not affect the win-stay effect (i.e. pressing the same lever after winning a trial). Furthermore, co-administration of beta-adrenoreceptor antagonist, propranolol, eliminated the effects of atomoxetine on risk taking and the lose-shift effect; but co-administration of alpha1-adrenoreceptor antagonist, prazosin, did not. Atomoxetine boosted NE levels and increased risk taking. This was because atomoxetine decreased rats' sensitivity to losses. These effects were likely mediated by beta-adrenoreceptor. Copyright © 2015 Elsevier Inc. All rights reserved.

ANALYSIS OF THE INFLUENCE OF A COMPANY’S INDEBTEDNESS ON THE FINANCIAL RISK

Directory of Open Access Journals (Sweden)

LĂPĂDUȘI MIHAELA LOREDANA

2015-06-01

Full Text Available Awareness of indebtedness and financial risk represents a great importance not only for the management of the company but also for creditors, investors, institutional investors, rating agencies, etc. An indebtedness analysis implies its effect on financial risk through financial lever coefficient or the financial lever. A financial lever is a notion originating in physics and it is the force that is applied in order to give a boost of a process or a phenomenon. However, in economics that notion was adapted and can be regarded as the strenght of different financial categories, financial instruments used in order to give a boost in a certain sense to various economic processes or activities in order to achieve the established objectives. More specifically we can say that the financial lever or the financial leverage expresses the impact of the financial structure over the company’s profitability. The research aims at analysing indebtedness and its influence over the financial risk and all the aspects underlined in the present article will prove the assumption that a company's performance and its capacity to produce profit depends mainly on the management and the use of financial resources. The purpose of present article is to highlight the impact of indebtedness over financial risk through the financial lever. The main objectives of the article set out to achieve this purpose are: the theoretical approach of a company's overall indebtedness, the analysis of the financial levers, and the analysis of the positive and negative leverage effects.

Immune responses in hepatitis B and C virus infection

NARCIS (Netherlands)

Stelma, F.

2017-01-01

Het hepatitis B en C virus zijn virussen die chronische infectie van de lever kunnen veroorzaken. Zulke langdurige ontsteking van de lever kan leiden tot leverschade, met als gevolg het ontstaan van cirrose en hepatocellulair carcinoom. Naar de behandeling van deze chronische virus infecties wordt

Method and system for dual resolution translation stage

Science.gov (United States)

Halpin, John Michael

2014-04-22

A dual resolution translation stage includes a stage assembly operable to receive an optical element and a low resolution adjustment device mechanically coupled to the stage assembly. The dual resolution stage also includes an adjustable pivot block mechanically coupled to the stage assembly. The adjustable pivot block includes a pivot shaft. The dual resolution stage further includes a lever arm mechanically coupled to the adjustable pivot block. The lever arm is operable to pivot about the pivot shaft. The dual resolution stage additionally includes a high resolution adjustment device mechanically coupled to the lever arm and the stage assembly.

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

Abstract. I review some of the recent progress (up to December 2005) in applying non-Abelian discrete symmetries to the family structure of leptons, with particular emphasis on the tribimaximal mixing ansatz of Harrison, Perkins and Scott.

Evaluation of antidiarrhoeal activity of the stem bark of Cylicodiscus ...

African Journals Online (AJOL)

GRACE

2006-06-02

Jun 2, 2006 ... (Cameroon), bouemon (Ivory Coast) (Chudnoff et al.,. 1984) is a large tree ... expressed as a percentage of inhibition of diarrhoea (Zaval et al.,. 1988). ..... SL, Longo DL (1993). Harrison's Principles of Internal Medicine. New.

2005 Mississippi Merged LiDAR Data (2005 LiDAR data merged with 2005 Post-Katrina LiDAR data to create a bare-earth product for flood plain mapping in coastal Mississippi).

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Pre- and post-hurricane Katrina LiDAR datasets of Hancock, Harrison, and Jackson Counties, MS, were merged into a seamless coverage by URS. The pre-Katrina LiDAR...

Preventing Pressure Sores

Medline Plus

Full Text Available ... L Sarah Harrison, OT Anne Bryden, OT The Role of the Social Worker after Spinal Cord Injury ... do to prevent pressure sores? play_arrow What role does diet and hydration play in preventing pressure ...

A preliminary geochemical study of zircons and monazites from ...

Indian Academy of Sciences (India)

R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

equation of Watson and Harrison (1983) predicts that zircon with Zr-contents ... tion equation of Montel (1993) predicts that the .... and geochemistry of the basalts of Gujarat state (western ... solution kinetics: implications for the thorium and light.

Sign-tracking (autoshaping) in rats: a comparison of cocaine and food as unconditioned stimuli.

Science.gov (United States)

Kearns, David N; Weiss, Stanley J

2004-11-01

A series of experiments was performed to determine whether sign-tracking would occur in rats with intravenous (i.v.) cocaine as the unconditioned stimulus. In Experiment 1, a retractable lever paired with food produced strong sign-tracking, but a lever paired with one of three doses of i.v. cocaine did not elicit any approach or contact behavior. Experiment 2 demonstrated that doses of cocaine that did not elicit sign-tracking would function as a positive reinforcer for a lever contact operant. In Experiment 3, an artificial consummatory response was added to make the cocaine reinforcement episode more behaviorally comparable to that occasioned by food. Although the rats readily performed this response when it was required to receive cocaine infusions, they still did not contact a lever that signaled the availability of these infusions. It appears that cocaine is different from other positive reinforcers (e.g., food, water, warmth, or intracranial stimulation) in that it will not produce sign-tracking in rats.

The structure of affective action representations: temporal binding of affective response codes.

Science.gov (United States)

Eder, Andreas B; Müsseler, Jochen; Hommel, Bernhard

2012-01-01

Two experiments examined the hypothesis that preparing an action with a specific affective connotation involves the binding of this action to an affective code reflecting this connotation. This integration into an action plan should lead to a temporary occupation of the affective code, which should impair the concurrent representation of affectively congruent events, such as the planning of another action with the same valence. This hypothesis was tested with a dual-task setup that required a speeded choice between approach- and avoidance-type lever movements after having planned and before having executed an evaluative button press. In line with the code-occupation hypothesis, slower lever movements were observed when the lever movement was affectively compatible with the prepared evaluative button press than when the two actions were affectively incompatible. Lever movements related to approach and avoidance and evaluative button presses thus seem to share a code that represents affective meaning. A model of affective action control that is based on the theory of event coding is discussed.

Does addressing gender inequalities and empowering women and girls improve health and development programme outcomes?

Science.gov (United States)

Taukobong, Hannah F G; Kincaid, Mary M; Levy, Jessica K; Bloom, Shelah S; Platt, Jennifer L; Henry, Sarah K; Darmstadt, Gary L

2016-12-01

This article presents evidence supporting the hypothesis that promoting gender equality and women's and girls' empowerment (GEWE) leads to better health and development outcomes. We reviewed the literature across six sectors-family planning (FP); maternal, newborn and child health (MNCH); nutrition; agriculture; water, sanitation and hygiene; and financial services for the poor-and found 76 studies from low and middle-income countries that met our inclusion criteria. Across these studies, we identified common GEWE variables that emerged repeatedly as significant predictors of sector outcomes. We grouped these variables into 10 thematic categories, which we termed 'gender-related levers'. These levers were then classified by the strength of evidence into Wedges, Foundations and Facilitators. Wedges are gender-related levers that had strong associations with improved outcomes across multiple sectors. They include: 'control over income/assets/resources', 'decision-making power' and 'education'. Elements of these levers overlap, but combined, they encapsulate agency. Increasing female agency promotes equality and broadly improves health and development for women, their families and their communities. The second classification, Foundations, displayed strong, positive associations across FP, MNCH and nutrition. Foundations have a more proximal relationship with sector outcomes and include: 'equitable interpersonal relationships', 'mobility' and 'personal safety'. Finally, the third group of levers, Facilitators, was associated with improved outcomes in two to three sectors and include: 'access to information', 'community groups', 'paid labour' and 'rights'. These levers make it easier for women and girls to achieve their goals and are more traditional elements of development programmes. Overall, gender-related levers were associated with improvements in a variety of health and development outcomes. Furthermore, these associations were cross-sectoral, suggesting that to

Energy transition? A lever for competitiveness

International Nuclear Information System (INIS)

Institut Montaigne

2013-01-01

At a time when the 'energy transition' is being hotly debated by the nation, the right energy policy will he based on three pillars: supply private and business consumers at attractive prices; contain the risks associated with excessively high dependence on external sources of supply; finally reduce environmental pollution. Making these fully operative will require that all prices reflect costs at national level and that a full-fledged energy policy be put in place by the European Union over the time frame 2030-2050. (author)

Püüd kaevuda vaataja alateadvusse / Karin Saarepuu

Index Scriptorium Estoniae

Saarepuu, Karin

2002-01-01

Lahatakse installatiivset keskkonnaprojekti "X arvab, et ta on Y, aga tegelikult on Z" Viljandis Kilpkonna galeriis, mis on Rotermanni soolalaos toimuva näituse nn. visiitkaart. Autoriteks on Marko Mäetamm ning Lucy Harrison ja Pete Nevin Suurbritanniast

Spinal Cord Injury 101

Medline Plus

Full Text Available ... L Sarah Harrison, OT Anne Bryden, OT The Role of the Social Worker after Spinal Cord Injury ... a spinal cord injury important? play_arrow What role does “compression” play in a spinal cord injury? ...

Fulltext PDF

Indian Academy of Sciences (India)

believed that blood vessels contained blood and air. It was Galen, the second century ... where it met blood from the arteries which contained air coming from the lungs. .... Technology, Doubleday, 1982. [2]. I Harrison ... IUCAA, Post Bag 4.

Insulin sensitivity of hepatic glucose and lipid metabolism in animal models of hepatic steatosis

NARCIS (Netherlands)

Grefhorst, Aldo

2006-01-01

De lever is betrokken bij de regulatie van zowel het koolhydraat als het vet metabolisme. De lever slaat glucose op als glycogeen, scheidt glucose uit, kan glucose maken uit bijvoorbeeld melkzuur en aminozuren (‘gluconeogenese’), zet glucose om in vet (‘de novo lipogenese’), verbrandt vetzuren in de

The Mean as the Balance Point: Thought Experiments with Measuring Sticks

Science.gov (United States)

Flores, A.

2008-01-01

This article presents activities to help students establish a connection between the mean and the balance point of a lever. The lever and its law are discussed briefly. Thought experiments with a meterstick are presented to emphasize different properties of the mean and weighted averages. (Contains 16 figures.)

Face-Sealing Butterfly Valve

Science.gov (United States)

Tervo, John N.

1992-01-01

Valve plate made to translate as well as rotate. Valve opened and closed by turning shaft and lever. Interactions among lever, spring, valve plate, and face seal cause plate to undergo combination of translation and rotation so valve plate clears seal during parts of opening and closing motions.

Rimonabant’s Reductive Effects on High Densities of Food Reinforcement, but not Palatability, in Lean and Obese Zucker Rats

Science.gov (United States)

Buckley, Jessica Lynn; Rasmussen, Erin B.

2014-01-01

Rationale Cannabinoid antagonists purportedly have greater effects in reducing the intake of highly palatable food compared to less palatable food. However, this assertion is based on free-feeding studies in which the amount of palatable food eaten under baseline conditions is often confounded with other variables, such as unequal access to both food options and differences in qualitative features of the foods. Objective We attempted to reduce these confounds by using a model of choice that programmed the delivery rates of sucrose and carrot-flavored pellets. Methods Lever-pressing of ten lean (Fa/Fa or Fa/fa) and ten obese (fa/fa) Zucker rats was placed under three conditions in which programmed ratios for food pellets on two levers were 5:1, 1:1, and 1:5. In Phase 1, responses on the two levers produced one type of pellet (sucrose or carrot); in Phase 2, responses on one lever produced sucrose pellets and on the other lever produced carrot pellets. After responses stabilized under each food ratio, acute doses of rimonabant (0, 3, and 10 mg/kg) were administered before experimental sessions. The number of reinforcers and responses earned per session under each ratio and from each lever was compared. Results and Conclusions Rimonabant reduced reinforcers in 1:5 and 5:1 food ratios in Phase 1, and across all ratios in Phase 2. Rimonabant reduced sucrose and carrot-flavored pellet consumption similarly; rimonabant did not affect bias toward sucrose, but increased sensitivity to amount differences in lean rats. This suggests that relative amount of food, not palatability, may be an important behavioral mechanism in the effects of rimonabant. PMID:24398820

Rimonabant's reductive effects on high densities of food reinforcement, but not palatability, in lean and obese Zucker rats.

Science.gov (United States)

Buckley, Jessica L; Rasmussen, Erin B

2014-05-01

Cannabinoid antagonists purportedly have greater effects in reducing the intake of highly palatable food compared to less palatable food. However, this assertion is based on free-feeding studies in which the amount of palatable food eaten under baseline conditions is often confounded with other variables, such as unequal access to both food options and differences in qualitative features of the foods. We attempted to reduce these confounds by using a model of choice that programmed the delivery rates of sucrose and carrot-flavored pellets. Lever pressing of ten lean (Fa/Fa or Fa/fa) and ten obese (fa/fa) Zucker rats was placed under three conditions in which programmed ratios for food pellets on two levers were 5:1, 1:1, and 1:5. In phase 1, responses on the two levers produced one type of pellet (sucrose or carrot); in phase 2, responses on one lever produced sucrose pellets and on the other lever produced carrot pellets. After responses stabilized under each food ratio, acute doses of rimonabant (0, 3, and 10 mg/kg) were administered before experimental sessions. The number of reinforcers and responses earned per session under each ratio and from each lever was compared. Rimonabant reduced reinforcers in 1:5 and 5:1 food ratios in phase 1, and across all ratios in phase 2. Rimonabant reduced sucrose and carrot-flavored pellet consumption similarly; rimonabant did not affect bias toward sucrose, but increased sensitivity to amount differences in lean rats. This suggests that relative amount of food, not palatability, may be an important behavioral mechanism in the effects of rimonabant.

Quantifying Social Motivation in Mice Using Operant Conditioning.

Science.gov (United States)

Martin, Loren; Iceberg, Erica

2015-08-08

In this protocol, social motivation is measured in mice through a pair of operant conditioning paradigms. To conduct the experiments, two-chambered shuttle boxes were equipped with two operant levers (left and right) and a food receptacle in one chamber, which was then divided from the second chamber by an automated guillotine door covered by a wire grid. Different stimulus mice, rotated across testing days, served as a social stimulus behind the wire grid, and were only visible following the opening of the guillotine door. Test mice were trained to lever press in order to open the door and gain access to the stimulus partner for 15 sec. The number of lever presses required to obtain the social reward progressively increased on a fixed schedule of 3. Testing sessions ended after test mice stopped lever pressing for 5 consecutive minutes. The last reinforced ratio or breakpoint can be used as a quantitative measure of social motivation. For the second paradigm, test mice were trained to discriminate between left and right lever presses in order to obtain either a food reward or the social reward. Mice were rewarded for every 3 presses of each respective lever. The number of food and social rewards can be compared as a measurement of the value placed upon each reward. The ratio of each reward type can also be compared between mouse strains and the change in this ratio can be monitored within testing sessions to measure satiation with a given reward type. Both of these operant conditioning paradigms are highly useful for the quantification of social motivation in mouse models of autism and other disorders of social behavior.

Comparative analyses of genetic risk prediction methods reveal ...

Indian Academy of Sciences (India)

2015-03-12

Mar 12, 2015 ... 1National Institute of Biomedical Genomics, Netaji Subhas Sanatorium (T. B. ... 2Institute of Post Graduate Medical Education and Research, J. C. Bose Road, ...... Torres D. M. and Harrison S. A 2008 Diagnosis and therapy of.

Indiana Jones on tagasi ja näitab, kuidas käituda / Kristiina Davidjants

Index Scriptorium Estoniae

Davidjants, Kristiina, 1974-

2008-01-01

22 mail esilinastub Steven Spielbergi järjekordne Indiana Jones'i film, kaasstsenaristiks ja produtsendiks George Lucas ja Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull"). Saaga varasemast kolmest filmist

Vandbænkebidere og colibakterier

DEFF Research Database (Denmark)

Christensen, Sarah Christine; Nissen, Erling; Arvin, Erik

2011-01-01

På trods af at der lever småorganismer i stort set alle drikkevandssystemer verden over, ved vi meget lidt om, hvordan organismerne påvirker bakterievæksten i vandet. Det er ikke tidligere undersøgt om eksempelvis vandbænkebidere (Asellus aquaticus), der lever i danske drikkevandsdistributioner, er...

29 CFR 1410.3 - Individual access requests.

Science.gov (United States)

2010-07-01

..., North Dakota, South Dakota, Michigan, and Ohio (except counties listed under the Southern Region). 3..., Floyd, Harrison, Crawford, Perry, Spencer, DuBois, Pike, Gibson, Posey, Vanderburgh, and Warrick); Ohio..., Caldwell, Livingston, Linn, Macon, Shelby, Randolph, Chariton, Carrol, Ray, Clay, Platte, Jackson...

'Of peasants, peacocks and priests; a Portuguese village'

OpenAIRE

Iturra, Raul

2009-01-01

Made on very early equipment, silent 8mm film and tape recorder. Narration by Sarah Harrison. An early product of the Rivers Video Project. A film about a north Portuguese village in 1985, based on the fieldwork of Raul Iturra

effect of environment and nitrogen application on the expression of ...

African Journals Online (AJOL)

Banana 21

2013-04-17

Apr 17, 2013 ... 4Department of Disease and Stress Biology, John Innes Centre, Norwich Research Park, Colney, ... at 26°C.The mother plants of each cultivar were sampled and ..... Harper G, Osuji JO, Heslop-Harrison JS, Hull R (1999b).

Case Report-Right iliac fossa mass in an HIV-positive woman

African Journals Online (AJOL)

(ART) in a clinical trial in Blantyre, Malawi, after meeting all the requirements of the study .... invasion, as in a female SLE patient described by Mok et al, who ... Hauser SL, Longo DL, James JL, editors, Harrison's principles of internal medicine.

Staphylococcal Blood Stream Infections in Cancer Patients

African Journals Online (AJOL)

All blood culture samples received from patients suspected of having ... previously reported by Silvia et al.[2] All the CoNS ... Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, et al., editor. Harrison's Manual of Medicine. 17th ed.

Hydrology of the alluvial, buried channel, basal Pleistocene and Dakota aquifers in west-central Iowa

Science.gov (United States)

Runkle, D.L.

1985-01-01

A ground-water resources investigation in west-central Iowa indicates that water is available from alluvial, buried channel, basal Pleistocene, and Dakota aquifers. The west-central Iowa area includes Audubon, Carrol1, Crawford, Greene, Guthrie, Harrison, Monona, and Shelby Counties.

MORPHOLOGICAL CHANGES IN POLYURETHANE COATINGS ON EXPOSURE TO WATER. (R828081E01)

Science.gov (United States)

When a polyurethane self-priming coating on a sol-gel treated aluminum panel was immersed in dilute Harrison's solution, subsequent change of the polyurethane coating surface was inspected with atomic force microscopy (AFM) and scanning electron microscopy (SEM). After immersi...

Disease: H00987 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available , Marton T, Maxwell S, Harrison BJ, Beeson D, Maher ER ... TITLE ... Germline mutation in DOK7 associated with...64-76 (2008) DOI:10.1016/j.ajhg.2007.11.006 ... PMID:19261599 (description, gene) ... AUTHORS ... Vogt J, Morgan NV

Maailma enim teenivad surnud kuulsused / Pille-Mai Helemäe

Index Scriptorium Estoniae

Helemäe, Pille-Mai

2008-01-01

Forbesi andmetel maailma enim raha teenivate surnud kuulsuste seas ka lauljad Elvis Presley (1935-1977), John Lennon (1940-1980), George Harrison (1943-2001), Tupac Shakur (1971-1996) ja näitlejad Marilyn Monroe (1926-1962), Steve McQueen (1930-1980)

In memoriam: Richard (Rick) G. Harrison—benefactor for ...

Indian Academy of Sciences (India)

Professor Richard Harrison (1946–2016), a most influential evolutionary biologist of ... were profoundly important in my development as a scientist and a person. ... observations to infer his love of family, but I am going to risk correction by those ...

DIGITAL FLOOD INSURANCE RATE MAP DATABASE, HARRISON COUNTY, KY

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk information and supporting data used to develop the risk data. The primary risk...

The Lithuanians : a 1930s perspective / E. J. Harrison

Index Scriptorium Estoniae

Harrison, E. J.

2000-01-01

Katkend Suurbritannia asekonsulina 1930ndatel aastatel Leedus töötanud E. J. Harrisoni raamatust "Lithuania : Past and Present". London, 1939. Katkend kirjeldab leedulaste rahvuslikku psüühikat, religioossust, kombeid ja ebausku

DIGITAL FLOOD INSURANCE RATE MAP DATABASE, HARRISON COUNTY, TEXAS

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk information and supporting data used to develop the risk data. The primary risk...

Observing Responses and Serial Stimuli: Searching for the Reinforcing Properties of the S-

Science.gov (United States)

Escobar, Rogelio; Bruner, Carlos A.

2009-01-01

The control exerted by a stimulus associated with an extinction component (S-) on observing responses was determined as a function of its temporal relation with the onset of the reinforcement component (S+). Lever pressing by rats was reinforced on a mixed random-interval extinction schedule. Each press on a second lever produced stimuli…

Effects of autoshaping procedures on 3H-8-OH-DPAT-labeled 5-HT1a binding and 125I-LSD-labeled 5-HT2a binding in rat brain.

Science.gov (United States)

Tomie, Arthur; Di Poce, Jason; Aguado, Allison; Janes, Amy; Benjamin, Daniel; Pohorecky, Larissa

2003-06-13

Effects of experience with Pavlovian autoshaping procedures on lever-press autoshaping conditioned response (CR) performance and 3H-8-OH-DPAT-labeled binding of 5-HT(1a) receptors as well as 125I-LSD-labeled binding of 5-HT(2a) receptors were evaluated in four groups of male Long-Evans hooded rats. Two groups of rats (Group Paired High CR and Group Paired Low CR) received Pavlovian autoshaping procedures wherein the presentation of a lever (conditioned stimulus, CS) was followed by the response-independent presentation of food (unconditioned stimulus, US). Rats in Group Paired High CR (n=12) showed more rapid CR acquisition and higher asymptotic levels of lever-press autoshaping CR performance relative to rats in Group Low CR (n=12). Group Omission (n=9) received autoshaping with an omission contingency, such that performing the lever-press autoshaping CR resulted in the cancellation the food US, while Group Random (n=9) received presentations of lever CS and food US randomly with respect to one another. Though Groups Omission and Random did not differ in lever-press autoshaping CR performance, Group Omission showed significantly lower levels of 3H-8-OH-DPAT-labeled 5-HT(1a) binding in post-synaptic areas (frontal cortex, septum, caudate putamen), as well as significantly higher plasma corticosterone levels than Group Random. In addition, Group Random showed higher levels of 3H-8-OH-DPAT-labeled 5-HT(1a) binding in pre-synaptic somatodendritic autoreceptors on dorsal raphe nucleus relative to each of the other three groups. Autoradiographic analysis of 125I-LSD-labeled 5-HT(2a) receptor binding revealed no significant differences between Groups Paired High CR and Paired Low CR or between Groups Omission and Random in any brain regions.

Blockade of muscarinic receptors impairs the retrieval of well-trained memory

Directory of Open Access Journals (Sweden)

Shogo eSoma

2014-04-01

Full Text Available Acetylcholine (ACh is known to play an important role in memory functions, and its deficit has been proposed to cause the cognitive decline associated with advanced age and Alzheimer’s disease (the cholinergic hypothesis. Although many studies have tested the cholinergic hypothesis for recently acquired memory, only a few have investigated the role of ACh in the retrieval process of well-trained cognitive memory, which describes the memory established from repetition and daily routine. To examine this point, we trained rats to perform a two-alternative forced-choice visual detection task. Each trial was started by having the rats pull upward a central-lever, which triggered the presentation of a visual stimulus to the right or left side of the display monitor, and then pulling upward a stimulus-relevant choice-lever located on both sides. Rats learned the task within 10 days, and the task training was continued for a month. Task performance was measured with or without systemic administration of a muscarinic ACh receptor (mAChR antagonist, scopolamine (SCOP, prior to the test. After 30 min of SCOP administration, rats stopped manipulating any lever even though they explored the lever and surrounding environment, suggesting a loss of the task-related associative memory. Three hours later, rats were recovered to complete the trial, but the rats selected the levers irrespective of the visual stimulus, suggesting they remembered a series of lever-manipulations in association with a reward, but not association between the reward and visual stimulation. Furthermore, an m1-AChR, but not nicotinic AChR antagonist caused a similar deficit in the task execution. SCOP neither interfered with locomotor activity nor drinking behavior, while it influenced anxiety. These results suggest that the activation of mAChRs at basal ACh levels is essential for the recall of well-trained cognitive memory.

Environmental Investigations and Analyses for Los Angeles-Long Beach Harbors, Los Angeles, California, 1973-1976.

Science.gov (United States)

1976-12-01

Christine Yonai Fred Piltz Ichthyology Jay Carroll Karl Lyde John Helle Scott Ralston S. Ishikawa Steve Subber Catherine Kusick Catherine Terry...Charles Greaves Catherine Link Susan Harrison Julie Thompson Kaoru 0. Kendis Ismay Stanley Randall Kendis Marine Technicians Bruce Adams Gene Mummert

Tähesadu kunstihoones

Index Scriptorium Estoniae

2005-01-01

Tallinna Kunstihoones Briti Nõukogu koostatud näitus "Supernoova". Kuraator Caroline Douglas. Osalevad Gary Hume, Liam Gillick, Jane & Louise Wilson, Sarah Morris, Haluk Akakce, Phillip Allen, Keith Coventry, Dan Norton, Toby Paterson, Tony Swain, John Wood & Paul Harrison, Richard Wright, Toby Ziegler

Download this PDF file

African Journals Online (AJOL)

User

The case notes all patients admitted to the medical wards of the ... Between 1973 and 1986, Harries et al found CAP to be among the ... Fine et al also did not consider other factors that might ..... Longo DL, Jameson JL. Harrison's Principles of.

A case of renal cell carcinoma and angiomyolipoma in an ...

African Journals Online (AJOL)

It is reported to occur in 3% of all malignancies in adults and .... In: Longo DL, Fauci AS, Kasper. DL, Hauser SL, Jameson J, Loscalzo J, eds. Harrison's Principles of Internal Medicine. 19th ed. ... Bissler JJ, Kingswood JC, Radzikowska E, et al.

Ward Round: A 43-year-old diabetic man with multiple joint pains

African Journals Online (AJOL)

9, 10, 11 However, all these have had no ... Henrique da Mota LM, Carneiro JN, Lima RA et al. ... Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson. JL, Loscalzo J. (2008). Harrison's principles of internal medicine. (17th ed.).

76 FR 3636 - Ocean Transportation Intermediary License Applicants

Science.gov (United States)

2011-01-20

..., Vice President, Application Type: New NVO & OFF License. CDS Global Logistics, Inc. (NVO & OFF), 1001... & Logistics LLC (NVO & OFF), Hoboken Business Center, 50 Harrison Street, Suite 204B, Hoboken, NJ 07030, Officers: Michelle L. Hasenauer, Manager (Qualifying Individual), Harbans S. Shrinkant, Manager...

5 CFR Appendix C to Subpart B of... - Appropriated Fund Wage and Survey Areas

Science.gov (United States)

2010-01-01

... of Columbia, Washington, DC Survey Area District of Columbia: Washington, DC Maryland: Charles... Illinois: Cook Du Page Kane Lake McHenry Will Area of Application. Survey area plus: Illinois: Boone De...: Harrison Jennings Scott Washington Louisiana Lake Charles-Alexandria Survey Area Louisiana: Allen...

THE UNITED STATES AND NIGERIAN RELATIONS:

African Journals Online (AJOL)

Mrs. I.D

2009-12-25

Dec 25, 2009 ... response from the Nigerian government. ... domestic crises that negatively impacts state stability, the US government ... Harrison C. Ajebon, Department of Political Science, University of Calabar, ..... Sweden. United Kingdom. Switzerland. Asia & far East. Japan ..... case Study of Nigeria, in Ikonnechidi and.

African Journal of Reproductive Health - Vol 6, No 2 (2002)

African Journals Online (AJOL)

Jennifer Smit, Lynn McFadyen, Abigail Harrison, Khangelani Zuma. Indigenous Healing Practices and Self-Medication amongst Pregnant Women in Cape Town, South Africa. Naeemah Abrahams, Rachel Jewkes, Zodumo Mvo. Tetanus Immunity among Pregnant Women Attending Antenatal Care in Dar es Salaam, ...

Disease: H00488 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available type and phenotype? ... JOURNAL ... Hum Mol Genet 6:695-707 (1997) DOI:10.1093/hmg/6.5.695 ... PMID:15877203 (drug) ... AUTHORS ... Lee PJ, Harr...ison EL, Jones MG, Jones S, Leonard JV, Chalmers RA ... TITLE ... L-carnitine and exe

An External Stakeholder Analysis of a United States Army Directorate of Contracting

Science.gov (United States)

2004-12-01

Bass Inc., 1996. Burton, R.M. and Obel, B., Strategic Organizational Diagnosis and Design: Developing Theory for Application, 2nd ed., Kluwer...Harrison, M.I. and Shirom, A., Organizational Diagnosis and Assessment: Bridging Theory and Practice, SAGE Publications, Inc., 1999. Kotter, J.P

Interionic pair potentials and partial structure factors of compound ...

Indian Academy of Sciences (India)

Hiroike. Formulae are applied to NaSn (Na, Sn, NaSn, Na3Sn) which is considered as a ... for not only physicists but also chemists and engineers. This study is ... alizing Harrison's [18] approach of pair-wise potential between the metallic ions.

Water Quality and Fecal-Indicator Detection in Response to an Impaired Urban Watershed: Turkey Creek "Gulf of Mexico Initiative Focus"; and a "Making a Visible Difference" Program

Science.gov (United States)

The historical communities of Turkey Creek originated in 1866, when a group of emancipated African-Americans purchased land in Harrison County, MS, along the Turkey Creek watershed. Many of the current members of this community are descendants from the original settlers. This wa...

Effect of short-term prefeeding and body weight on wheel running and responding reinforced by the opportunity to run in a wheel.

Science.gov (United States)

Belke, Terry W; Pierce, W David; Jensen, K

2004-07-30

A biobehavioural analysis of activity anorexia suggests that the motivation for physical activity is regulated by food supply and body weight. In the present experiment, food allocation was varied within subjects by prefeeding food-deprived rats 0, 5, 10 and 15 g of food before sessions of lever pressing for wheel-running reinforcement. The experiment assessed the effects of prefeeding on rates of wheel running, lever pressing, and postreinforcement pausing. Results showed that prefeeding animals 5 g of food had no effect. Prefeeding 10 g of food reduced lever pressing for wheel running and rates of wheel running without a significant change in body weight; the effect was, however, transitory. Prefeeding 15 g of food increased the animals' body weights, resulting in a sustained decrease of wheel running and lever pressing, and an increase in postreinforcement pausing. Overall the results indicate that the motivation for physical activity is regulated by changes in local food supply, but is sustained only when there is a concomitant change in body weight.

Dynamics of Choice: Relative Rate and Amount Affect Local Preference at Three Different Time Scales

Science.gov (United States)

Aparicio, Carlos F.; Baum, William M.

2009-01-01

To examine extended control over local choice, the present study investigated preference in transition as food-rate ratio provided by two levers changed across seven components within daily sessions, and food-amount ratio changed across phases. Phase 1 arranged a food-amount ratio of 4:1 (i.e., the left lever delivered four pellets and the right…

From experimental zoology to big data: Observation and integration in the study of animal development.

Science.gov (United States)

Bolker, Jessica; Brauckmann, Sabine

2015-06-01

The founding of the Journal of Experimental Zoology in 1904 was inspired by a widespread turn toward experimental biology in the 19th century. The founding editors sought to promote experimental, laboratory-based approaches, particularly in developmental biology. This agenda raised key practical and epistemological questions about how and where to study development: Does the environment matter? How do we know that a cell or embryo isolated to facilitate observation reveals normal developmental processes? How can we integrate descriptive and experimental data? R.G. Harrison, the journal's first editor, grappled with these questions in justifying his use of cell culture to study neural patterning. Others confronted them in different contexts: for example, F.B. Sumner insisted on the primacy of fieldwork in his studies on adaptation, but also performed breeding experiments using wild-collected animals. The work of Harrison, Sumner, and other early contributors exemplified both the power of new techniques, and the meticulous explanation of practice and epistemology that was marshaled to promote experimental approaches. A century later, experimentation is widely viewed as the standard way to study development; yet at the same time, cutting-edge "big data" projects are essentially descriptive, closer to natural history than to the approaches championed by Harrison et al. Thus, the original questions about how and where we can best learn about development are still with us. Examining their history can inform current efforts to incorporate data from experiment and description, lab and field, and a broad range of organisms and disciplines, into an integrated understanding of animal development. © 2015 Wiley Periodicals, Inc.

Panmixia in East African Populations of Platygyra daedalea ...

African Journals Online (AJOL)

genome were used to measure differentiation between populations of P. daedalea. Of 350 specimens successfully amplified for one or ... they employ a similar strategy (Mangubhai. & Harrison, 2006) and undergo subsequent ..... that could lead to the levels of heterozygosity observed in this study include small effective.

Plaadid / Valner Valme

Index Scriptorium Estoniae

Valme, Valner, 1970-

2002-01-01

Uutest plaatidest Motion Picture Soundtrack "Brown Sugar", Marc Bolan & T. Rex "The essential Collection", Ace of Base "Da Capo", Serge Gainsbourg "Initials SG. Best of", George Harrison "Brainwashed", Barbariz/Pastacas "Dehemardik Datis", Kyoto Jazz Massive "Spirit Of The Sun", Pain "Nothing Remains the Same"

76 FR 71441 - Enhanced-Use Lease (EUL) of Department of Veterans Affairs (VA) Real Property for the Development...

Science.gov (United States)

2011-11-17

...) Real Property for the Development of a Permanent Housing Facility in Fort Harrison, MT AGENCY..., design, develop, construct, manage, maintain and operate the EUL development. As consideration for the... to eligible Veterans in the geographic service- delivery area within which the property is located...

African Journal of AIDS Research - Vol 8, No 1 (2009)

African Journals Online (AJOL)

Conceptions of mental health among Ugandan youth orphaned by AIDS · EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD ... TEXT DOWNLOAD FULL TEXT. Kathleen McDavid Harrison, Johanna Claass, Paul B Spiegel, Judith Bamuturaki, Njogu Patterson, Michael Muyonga, Lillian Tatwebwa ...

Asymmetric skew Bessel processes and their applications to finance

NARCIS (Netherlands)

Decamps, M.; Goovaerts, M.J.; Schoutens, W.

2006-01-01

In this paper, we extend the Harrison and Shepp's construction of the skew Brownian motion (1981) and we obtain a diffusion similar to the two-dimensional Bessel process with speed and scale densities discontinuous at one point. Natural generalizations to multi-dimensional and fractional order

Leisure managers’ perceptions of employee diversity and impact of employee diversity

NARCIS (Netherlands)

Garib, Y.R.

2013-01-01

This aim of the study is to gain more insight in diversity perceptions and the diversity benefits in the leisure industry by investigating the impact of leisure managers’ diversity perceptions on organizational performance perceptions. The diversity typology of Harrison and Klein (2007) based on

Den 'dygtige' lærer er en del af problemet

DEFF Research Database (Denmark)

Hedegaard-Sørensen, Lotte

2016-01-01

Lærerne lever faktisk op til politikernes forestilling om ’den gode undervisning’, men dermed bliver de en del af problemet og ikke løsningen på folkeskolens inklusionsudfordring......Lærerne lever faktisk op til politikernes forestilling om ’den gode undervisning’, men dermed bliver de en del af problemet og ikke løsningen på folkeskolens inklusionsudfordring...

Growth of Candida famata and Trichosporon cutaneum on uric acid as the sole source of carbon and energy, a hitherto unknown property of yeasts

NARCIS (Netherlands)

Middelhoven, W.J.; Brink, Jolanda A. van den; Veenhuis, M.

1983-01-01

Yeast strains capable of utilizing uric acid as the sole source of carbon and energy were isolated from soil by the enrichment culture method. The strains were identified as Candida famata (Harrison) Meyer et Yarrow and Trichosporon cutaneum (De Beurm., Gougerot et Vaucher) Ota. On the subcellular

issue 2 2008.indb

African Journals Online (AJOL)

Malawi Medical Journal; 20(2):57 - 63 June 2008. Abstract ... procedures, ignorance of health research, fear of strangers, ..... Harrison, D. A. Volunteer motivation and attendance decisions: competitive theory testing in multiple samples from a homeless shelter. ... led organization whose goal is to promote and protect the.

Original Article

African Journals Online (AJOL)

102640

Key words: Genotypes, HCV, Risk factors, Libyan patients. ABSTRACT ... transmission of HCV, as well as measures to control the problem of intravenous drug users in the community. ..... strong indicator that strict infection control ... Harrison's Principles of internal medicine. 16th ... management and treatment of Hepatitis C.

Operation DOMINIC I-1962.

Science.gov (United States)

1983-02-01

OOMINIC. Quantity Item 4 Sellers Injector Corp. Liquid Jet Cleaners with Lance and Discharge Hose 2 Gelman Air Sampler with Dry Test Meter 2 289 Tritium...Veterans Administration - RO Fort Harrison, MT San Juan , Puerto Rico ATTN: Director ATTN: Director p. Veterans Administration - RO Veterans Administration

Association between HLA-DQA1 gene copy number polymorphisms ...

Indian Academy of Sciences (India)

2014-04-21

Apr 21, 2014 ... 2007), type 1 diabetes (T1D) (Grayson et al. 2010), ... The aim of this study was to explore HLA-DQA1. CNVs that potentially .... McKinney C. and Merriman T. R. 2012 Meta-analysis confirms a ... Harrison A. A., Highton J. et al.

The potential impacts of climate change on hydropower: An ...

African Journals Online (AJOL)

Osborne

Climate change has the potential to affect hydropower generation by either increasing or reducing flows (discharge) and the head. .... evapotranspiration levels thus reducing the runoff. (Harrison et al., 1998). Therefore .... The discharge rates are determined by factors such as climate, vegetation, soil type, drainage basin ...

Learning to Lead against the Grain: Dramatizing the Emotional Toll of Teacher Leadership

Science.gov (United States)

Cranston, Jerome; Kusanovich, Kristin

2015-01-01

Tremendous research on teacher leadership over the last decade has revealed both the prevalence of and the imperatives for a model teaching force that can actively participate in school improvement (Harrison & Killion, 2007; Katzenmeyer & Moller, 2001; Leithwood & Riehl, 2003). The highly participative teacher leader paradigm is so…

South African Medical Journal - Vol 88, No 11 (1998)

African Journals Online (AJOL)

An assessment of the 'road-to-health' card based on perceptions of clinic staff and mothers · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. D Harrison, H de V. Heese, H Harker, M.D. Mann, 1424-1428 ...

A.D.E.L.A.N.T.E. Alliance for Developing and Enhancing Latino Awareness and Needs in Teacher Education.

Science.gov (United States)

Montoya, Alicia L.

ADELANTE (Spanish for Forward), Alliance for Developing and Enhancing Latino Awareness and Needs in Teacher Education, is a program designed to enhance the cultural sensitivity and teaching skills of experienced teachers. Developed cooperatively by Harrison-Morton Middle School, Kutztown University, and the community-based organization, Casa…

Characterization of the polyphenol composition of 20 cultivars of cider, processing, and dessert apples (Malus × domestica Borkh.) grown in Virginia.

Science.gov (United States)

Thompson-Witrick, Katherine A; Goodrich, Katheryn M; Neilson, Andrew P; Hurley, E Kenneth; Peck, Gregory M; Stewart, Amanda C

2014-10-15

Polyphenols and maturity parameters were determined in 20 apple cultivars with potential for hard cider production grown in Virginia, U.S.A. Concentrations of five classes of polyphenols were significantly different across cultivar for both peel and flesh. Total polyphenol concentration ranged from 0.9 μg/g wwb in flesh of Newtown Pippin to 453 μg/g wwb in peel of Red Delicious. Harrison, Granny Smith, Rome, Winesap, and Black Twig cultivars contained the highest concentration of total flavan-3-ols in flesh, indicating potential to impart desired astringency and bitterness to cider under processing conditions where extraction of polyphenols from peel is minimal. These results can inform selection of fruit juice, extracts, and byproducts for investigations of bioactivity and bioavailability of polyphenols, and provide baseline data for horticultural and processing research supporting the growing hard cider industry in Virginia. Based on these data, cultivars Harrison, Granny Smith, Rome, Winesap, and Black Twig show high potential for cider production in Virginia.

Equipment for capping drums, especially with radioactive waste

International Nuclear Information System (INIS)

Bednarik, F.

1987-01-01

The equipment consists of a pneumatic cylinder, lever systems with jaws, guide bars, and of securing pins. The top cylinder lid and the bottom cylinder lid provided with openings are slidably attached to a shaft firmly connected to a piston and a support plate. Firmly attached to the bottom lid using brackets are pins holding connecting rods controlling the double-arm levers pivoted on pins, featuring jaws pivoted on forks firmly attached to the support plate and provided with a replaceable spacer insert. The guide bars are firmly attached to the support plate via braces and stiffeners. The securing pins are loaded with springs seated in the braces. The benefits of the equipment include that the lid closing levers with jaws, mechanically controlled using one pneumatic cylinder, thanks to their number and configuration, close the lid around the drum border provided with small recesses which do not reach above the circumference of the drum being closed. The equipment can also be used for carrying closed drums, this also during compressed air failures because the levers with jaws are secured in position with the pneumatic cylinder leg. (J.B.). 1 fig

Concurrent progressive-ratio schedules: built-in controls in the study of delayed reward efficacy.

Science.gov (United States)

Jarmolowicz, David P; Hudnall, Jennifer L

2014-08-15

Delayed rewards maintain lower rates of operant responding than immediate rewards, and when given a choice between immediate and delayed rewards, individuals typically choose the immediate reward, even when it is smaller (a phenomenon called delay discounting). The behavioral and neural mechanisms underlying these behavioral patterns, however, are not conclusively understood. The present study developed a method to examine the efficacy of delayed rewards in a way that is suitable for pharmacological manipulation of delayed reward efficacy (while controlling for general changes in reward efficacy). The progressive ratio (PR) paradigm often used to examine reward efficacy was modified such that two PR schedules for lever pressing concurrently yet independently were presented. Across a series of conditions, a range of delays (3-81s) were arranged on one of the levers while the reward on the other lever remained immediate. PR breakpoints (the highest ratio completed on each lever, our measure of reward efficacy) systematically decreased on the delayed, but not on the immediate reward lever, suggesting that delays decreased reward efficacy. This decrease in breakpoint resulted in bias in within-session responding that was accounted for by models that adjusted reward value by the delay to that reward. Unlike the standard PR paradigm, the present arrangement provided the controls needed to differentiate delay specific from general changes in reward efficacy. The present method should be helpful in the study of the behavioral and neural mechanisms of delayed reward efficacy. Modifications of the present paradigm should be useful for pharmacological studies. Copyright © 2014 Elsevier B.V. All rights reserved.

The effects of nicotine exposure during Pavlovian conditioning in rats on several measures of incentive motivation for a conditioned stimulus paired with water.

Science.gov (United States)

Guy, Elizabeth Glenn; Fletcher, Paul J

2014-06-01

Nicotine enhances approach toward and operant responding for conditioned stimuli (CSs), but the effect of exposure during different phases of Pavlovian incentive learning on these measures remains to be determined. These studies examined the effects of administering nicotine early, late or throughout Pavlovian conditioning trials on discriminated approach behavior, nicotine-enhanced responding for conditioned reinforcement, extinction, and the reinstatement of responding for conditioned reinforcement. We also tested the effect of nicotine on approach to a lever-CS in a Pavlovian autoshaping procedure and for this CS to serve as a conditioned reinforcer. Thirsty rats were exposed to 13 conditioning sessions where a light/tone CS was paired with the delivery of water. Nicotine was administered either prior to the first or last seven sessions, or throughout the entire conditioning procedure. Responding for conditioned reinforcement, extinction, and the reinstatement of responding by the stimulus and nicotine were compared across exposure groups. Separately, the effects of nicotine on conditioned approach toward a lever-CS during autoshaping, and responding for that CS as a conditioned reinforcer, were examined. Nicotine exposure was necessary for nicotine-enhanced responding for conditioned reinforcement and the ability for nicotine and the stimulus to additively reinstate responding on the reinforced lever. Nicotine increased contacts with a lever-CS during autoshaping, and removal of nicotine abolished this effect. Prior nicotine exposure was necessary for nicotine-enhanced responding reinforced by the lever. Enhancements in the motivating properties of CSs by nicotine occur independently from duration and timing effects of nicotine exposure during conditioning.

Enhanced performance of aged rats in contingency degradation and instrumental extinction tasks.

Science.gov (United States)

Samson, Rachel D; Venkatesh, Anu; Patel, Dhara H; Lipa, Peter; Barnes, Carol A

2014-04-01

Normal aging in rats affects behavioral performance on a variety of associative learning tasks under Pavlovian conditions. There is little information, however, on whether aging also impacts performance of instrumental tasks. Young (9-12 months) and aged (24-27 months) Fisher 344 rats were trained to press distinct levers associated with either maltodextrin or sucrose. The rats in both age groups increased their lever press frequency at a similar rate, suggesting that the initial acquisition of this instrumental task is not affected by aging. Using a contingency degradation procedure, we then addressed whether aged rats could adapt their behavior to changes in action-outcome contingencies. We found that young and aged rats do adapt, but that a different schedule of reinforcement is necessary to optimize performance in each age group. Finally, we also addressed whether aged rats can extinguish a lever press action as well as young rats, using 2 40-min extinction sessions on consecutive days. While extinction profiles were similar in young and aged rats on the first day of training, aged rats were faster to extinguish their lever presses on the second day, in spite of their performance levels being similar at the beginning of the session. Together these data support the finding that acquisition of instrumental lever press behaviors is preserved in aged rats and suggest that they have a different threshold for switching strategies in response to changes in action-outcome associations. This pattern of result implies that age-related changes in the brain are heterogeneous and widespread across structures.

Well below 2 °C: Mitigation strategies for avoiding dangerous to catastrophic climate changes

Science.gov (United States)

Xu, Yangyang; Ramanathan, Veerabhadran

2017-09-01

The historic Paris Agreement calls for limiting global temperature rise to “well below 2 °C.” Because of uncertainties in emission scenarios, climate, and carbon cycle feedback, we interpret the Paris Agreement in terms of three climate risk categories and bring in considerations of low-probability (5%) high-impact (LPHI) warming in addition to the central (˜50% probability) value. The current risk category of dangerous warming is extended to more categories, which are defined by us here as follows: >1.5 °C as dangerous; >3 °C as catastrophic; and >5 °C as unknown, implying beyond catastrophic, including existential threats. With unchecked emissions, the central warming can reach the dangerous level within three decades, with the LPHI warming becoming catastrophic by 2050. We outline a three-lever strategy to limit the central warming below the dangerous level and the LPHI below the catastrophic level, both in the near term (pollutant (SP) lever to mitigate short-lived climate pollutants, and the carbon extraction and sequestration (CES) lever to thin the atmospheric CO2 blanket. Pulling on both CN and SP levers and bending the emissions curve by 2020 can keep the central warming below dangerous levels. To limit the LPHI warming below dangerous levels, the CES lever must be pulled as well to extract as much as 1 trillion tons of CO2 before 2100 to both limit the preindustrial to 2100 cumulative net CO2 emissions to 2.2 trillion tons and bend the warming curve to a cooling trend.

Derivation and application of hydraulic equation for variable-rate ...

African Journals Online (AJOL)

use

2011-12-12

Dec 12, 2011 ... and a lever element having a cam engaging element which engages the cam surface, the lever element being operatively coupled to the valve such that the contour of the cam surface causes the ... When. 0. →∆ t. , there are. 0. →∆ α and. OA. OB → . The wetted area of the VRCS S. ∆ during this very short ...

ADMINISTRATIVE INSTRUMENTS IN IMPLEMENTING FUNCTIONAL STRATEGIES COMPETITIVENESS MANAGEMENT

OpenAIRE

Stankovska, Iryna

2017-01-01

The article explores the use of  аdministrative instruments in implementing functional strategies competitiveness management. Due to providing strategic financial management competitiveness the use of administrative levers of control in the formulation and implementation of financial strategies were investigated. System of financial policies forming by individual policies of  general financial strategy, which is an administrative levers of influence on implementation strategies, was proposed...

Books | Gordon | South African Medical Journal

African Journals Online (AJOL)

Illustrated.London and New York: Royal Society of Medicine Services. 1990. Internal medicine Harrison's Principles of Internal Medicine. 12th ed. Bd. by ].D. Wilson, E. Braunwald, K.]. Isselbacher, et al. pp. xxx + 2208. Illustrated. USA: McGraw-Hill. 1991. HPV and cervical cancer Human Papillomavirus and Cervical Cancer.

Testing the performance of beta diversity measures based on incidence data: the robustness to undersampling

DEFF Research Database (Denmark)

Bondoso Cardoso, Pedro Miguel; Borges, Paulo A. V.; Veech, Joseph A.

2009-01-01

computing beta diversity for selected pairs of samples. The robustness of these beta diversity accumulation curves was assessed for the purpose of finding the best measures for undersampled communities. Results The Harrison et al.ß-2 and the Williams ß-3 are particularly robust to undersampling...

Medical Problems Related to Altitude in: Human Performance Physiology and Environmental Medicine at Terrestrial Extremes. Chapter 14,

Science.gov (United States)

1987-10-01

function primarily to increase oxygen availability at the tissue level. The most significant changes occur in the cardiovascular and pulmonary systems...52. 40. Monge, M.C. La Enfermedad de Los Andes. Sindromes Eritremicos. Ann. Fac. Med. (Peru) 11:1, 1928. 41. Moore, L..G., G.L. Harrison, R.E

Developmental Kindergarten Program Evaluation Report.

Science.gov (United States)

Blois, George T.; Cushing, Katherine S.

The evaluation of the Developmental Kindergarten (DK) Program at the Harrison School District #2, Colorado Springs, Colorado, involved pre- and post-testing of student academic gains and interviewing of principals and teachers. The program aimed to provide developmentally appropriate activities for students believed to be "at risk" of…

Accuracy Assessment of Global Barotropic Ocean Tide Models

Science.gov (United States)

2014-08-07

Altimetry, Venice . Cartwright, D. E. (1999), Tides: A Scientific History , Cambridge Univ. Press, New York. Cartwright, D. E., and R. D. Ray (1990), Oceanic...E. Harrison, and D. Stammer, p. 4, ESA Publication WPP-306, Venice , Italy. Book, J. W., H. Perkins, and M. Wimbush (2009), North Adriatic tides

76 FR 5607 - Notice of Intent To Prepare a Resource Management Plan for the Rock Springs Field Office, Wyoming...

Science.gov (United States)

2011-02-01

.../programs/Planning/rmps/RockSprings.html ; E-mail: [email protected] ; Fax: (307) 352- 0218; or Mail... the project mailing list, contact Vera-Lynn Harrison, Project Manager, at (307) 352-0259 or Vera... address, phone number, e-mail address, or other personal identifying information in your comment, you...

The seismicity of Ethiopia; active plate tectonics

Science.gov (United States)

Mohr, P.

1981-01-01

"But I tell you, when you look at the way the pieces of the northeastern portion of the African continent seem to fit together, separated by a narrow gulf, you could almost make a believer [in continental drift] of anybody" Astronaut Harrison Schmidt, on the view from Apollo 17.

Dollar Summary of Federal Supply Classification and Service Category by Company, FY83, Part 6 (W061-Z299).

Science.gov (United States)

1983-01-01

RENT OF FAC /FUEL SUPPLY 29 X299 AUTO TECHNIQUE BELGIQUE S A BELGIUM ARMY LEASE-RENT OF FAC /OTHER NON-BLDG STRUCT 31 HOFFMAN CO VIRGINIA ARMY LEASE...HARRISON & PALMI RIDGE ELECTRICAL E INC MISSOURI ARMY CONSTR: CONSTRUCTION/PARFING FACILITIES $ 123 SUSSEX ELECTRICO C MARYLAND ARMY CONSTR: CONSTRUCTION

75 FR 13576 - Labor Surplus Area Classification Under Executive Orders 12073 and 10582

Science.gov (United States)

2010-03-22

... County, GA. Jefferson County, GA Jefferson County, GA. Jenkins County, GA Jenkins County, GA. Johnson.... Henry County, IN Henry County, IN. Kokomo city, IN Howard County, IN. LaGrange County, IN LaGrange..., OH Harrison County, OH. Henry County, OH Henry County, OH. Highland County, OH Highland County, OH...

Towards mastery of complex visuo-motor transformations

Directory of Open Access Journals (Sweden)

Herbert eHeuer

2013-02-01

Full Text Available In this paper we review and integrate a set of findings on learning the transformation of a sliding first-order lever, a type of tool with a prominent role in minimal access surgery. Its kinematic transformation is characterized by the so-called fulcrum effect, the inversion of the movement direction of the tip of the lever relative to that of the hand for rotations. A second characteristic is gain anisotropy, which results in curved paths of the tip of the lever for straight paths of the hand and vice versa. An internal model of the kinematic transformation is acquired during practice, the accuracy of which can be assessed in visual open-loop test trials. The accuracy of the acquired internal model is enhanced when visual closed-loop control during practice is impeded, and the accuracy of the internal model is reduced when closed-loop control during practice is facilitated. The internal model consists of a rapidly acquired line-symmetric approximation to the transformation of the sliding lever and a slowly acquired fine tuning. The fine tuning is local, that is, it is specific for the region of the workspace encountered during practice. The internal model is transferred to other regions of the workspace, but not adjusted to the fine tuning appropriate for these regions. Whereas the symmetry approximation is most likely explicit, the fine tuning seems to be represented implicitly. Findings on the straightness of the paths of the tip of the lever and the hand suggest that the internal model of the transformation is confined to initial and final positions of aimed movements, whereas their path is not strictly controlled, but affected by the dynamic transformation of the tool. Only when visual closed-loop control is possible, the path of the effective part of the tool is straightened. These characteristics of the internal model of the sliding first-order lever and its acquisition may be partly specific to sufficiently complex extrinsic

Design of creep machine and creep specimen chamber for carrying out creep tests in flowing liquid sodium

Energy Technology Data Exchange (ETDEWEB)

Ravi, S., E-mail: sravi@igcar.gov.in; Laha, K.; Sakthy, S.; Mathew, M.D.; Jayakumar, T.

2014-02-15

Highlights: • Design of a lever type creep machine for carrying out creep test in flowing sodium. • Leveling of lever during creep was achieved by automated movement of fulcrum. • Design of creep chamber for providing constant sodium flow rate across creep specimen. • Minimum use of bellow in chamber for sodium containment and mechanical isolation. • Mini-lever mechanism to counter balance load reduction on specimen due to bellow stiffness. - Abstract: A creep testing system has been designed, fabricated, installed and validated for carrying out creep tests in flowing liquid sodium. The testing system consists of two sections namely creep testing machine and an environmental chamber. The testing system has the ability of (i) applying tensile load to the test specimen through a lever, (ii) monitoring continuously the creep elongation and (iii) allowing sodium to flow around the creep specimen at constant velocity. The annular space between the creep specimen and the environmental chamber has been suitably designed to maintain constant sodium flow velocity. Primary and secondary bellows are employed in the environmental chamber to (i) mechanically isolate the creep specimen, (ii) prevent the flowing sodium in contact with air and (iii) maintain an argon gas cover to the leaking sodium if any from primary bellow, with a provision to an alarm get activated by a spark plug. The lever-horizontality during creep test has been maintained by automatically lifting up the fulcrum instead of lowering down the pull rod as conventionally used. A mini lever mechanism has been incorporated in the load train to counter balance the load reduction on specimen from the changing stiffness of the bellows. The validation of the testing system has been established by carrying out creep tests on 316L(N) stainless steel at 873 K over a wide stress range and comparing the results with those obtained in air by employing the developed and conventional creep testing machines.

Nucleus accumbens opioid, GABaergic, and dopaminergic modulation of palatable food motivation: contrasting effects revealed by a progressive ratio study in the rat.

Science.gov (United States)

Zhang, Min; Balmadrid, Christian; Kelley, Ann E

2003-04-01

The current studies were designed to evaluate whether incentive motivation for palatable food is altered after manipulations of opioid, GABAergic, and dopaminergic transmission within the nucleus accumbens. A progressive ratio schedule was used to measure lever-pressing for sugar pellets after microinfusion of drugs into the nucleus accumbens in non-food-deprived rats. The mu opioid agonist D-Ala2, NMe-Phe4, Glyo15-enkephalin and the indirect dopamine agonist amphetamine induced a marked increase in break point and correct lever-presses; the GABA(A) agonist muscimol did not affect breakpoint or lever-presses. The data suggest that opioid, dopaminergic, and GABAergic systems within the accumbens differentially modulate food-seeking behavior through mechanisms related to hedonic evaluation of food, incentive salience, and control of motor feeding circuits, respectively.

Digitization and the open management of data: New prospects for electricity distributors

International Nuclear Information System (INIS)

Derdevet, Michel

2017-01-01

At the core of both the energy transition and the digital revolution are the grids for distributing electricity during this era of big data. The electricity grid is becoming smarter and smarter, as it is equipped with sensors capable of providing information and data - the leading example being the 35 million smart electricity meters to be installed in French households by 2021. Backed by recent legislation, the trend toward open data is, for distributors, both a requirement and a lever: an economic, social and environmental requirement for enabling localities to prove their sense of responsibility and for developing innovative services for citizens; but also a lever for distributors to become operators who, processing dynamic data, are open to their ecosystem - a lever for making new business models emerge for the local management of energy

Interdisciplinary Approach: A Lever to Business Innovation

Science.gov (United States)

Razmak, Jamil; Bélanger, Charles H.

2016-01-01

The advances in interdisciplinary studies are driving universities to utilize their available resources to efficiently enable development processes and provide increasing examples of research while gradually allocating the disciplines' resources. Ultimately, this trend asks universities to provide a platform of integrated disciplines, along with…

Carbon pricing. A lever for energy transition

International Nuclear Information System (INIS)

2016-01-01

The international community has set itself the target of limiting the global temperature rise to 2 deg. C. In today's world, the challenge is to invent new ways of manufacturing goods, producing food, travelling and keeping ourselves warm, without emitting more greenhouse gases (GHG) into the atmosphere than what we are technically able to remove from it. Climate action can be considered as an insurance for our societies against unacceptable costs generated by the risk of increasingly frequent climate-triggered natural disasters, irreversible damage to ecosystems and mass population migrations. In addition to avoid climate damage there are many benefits of climate action, including greater energy autonomy, reduced atmospheric pollution, which is harmful for human health, and the economic benefits of new green growth sectors. However, the efforts needed to make the transition to economies that emit fewer greenhouse gases must not be underestimated. This transition requires the mass redirection of investments into clean transport, renewable energy sources, building insulation and the development of agro-ecology, in a highly restricted financial and budgetary context. The economic and financial tools used for explicit or implicit carbon pricing give clear messages about the benefits of emitting less carbon, or alternatively the cost of greenhouse gas emissions for society. Consequently, they make it possible to accelerate the energy transition. 74 countries and over 1,000 businesses formed a coalition for carbon pricing during the United Nations Climate Summit in September 2014, held at the invitation of the UN Secretary-General. The goal of the coalition is to promote productive dialogue between public and private decision-makers concerning opportunities to extend carbon pricing policies. It has been officially launched on November 30, 2015, on the opening day of COP21. It has been officially launched on November 30, 2015, on the opening day of COP21. Members of the coalition include France, Germany, Mexico, Canada, Chile and Ethiopia. The national low-carbon strategy organises the reduction of greenhouse gas emissions sector by sector. The strategy shares five-year targets with economic players and offers opportunities to better coordinate efforts by drawing on a range of tools where carbon pricing will have a key role to play. (authors)

Human Trafficking as Lever for Feminist Voices?

DEFF Research Database (Denmark)

Spanger, Marlene

2011-01-01

that lies behind policies on prostitution by identifying ruptures and discursive struggles which lead to transformations of the policy field. In particular, this article investigates how the problematisation of human trafficking has created space for a feminist discourse breakthrough within the policy field...

Creative Climate: A Leadership Lever for Innovation

Science.gov (United States)

Isaksen, Scott G.; Akkermans, Hans J.

2011-01-01

The working atmosphere within an organization has an important influence on its level of innovative productivity. Organizational leaders influence innovative productivity as well as the climate for creativity and innovation. This exploratory study included 140 respondents from 103 different organizations, 31 industries, and 10 countries, all of…

Book Review: Housing and Health: The relationship between ...

African Journals Online (AJOL)

Book Review: Housing and Health: The relationship between housing conditions and the health of council tenants. SA Okanlawon. Abstract. D. S. Bryne, S. P. Harrison, J. Keithley, and P. McCarthy (1986). Gower, England. 149pp. Hardcover. ISBN: O 566 00864 5. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL ...

the distribution of hair on the phalanges of a sample population

African Journals Online (AJOL)

Daniel Owu

special and cherished feature especially in females. Hair is a filamentous keratnised structure present over almost all of the body surface (Junqueira et al,. 2005). It is a derivative of the epidermis which assists in thermoregulation and provides some protection against injury (Harrison and Davies, 1999; Williams et al; 2005).

40 CFR 81.316 - Iowa.

Science.gov (United States)

2010-07-01

... Remainder of Lee County X Cedar Rapids—a portion of Linn County contained entirely within T 82 N., R 7 W... Greene County Grundy County Guthrie County Hamilton County Hancock County Hardin County Harrison County... County Johnson County Jones County Keokuk County Kossuth County Lee County Linn County Louisa County...

A Spreadsheet Model That Estimates the Impact of Reduced Distribution Time on Inventory Investment Savings: What is a Day Taken Out of the Pipeline Worth in Inventory?

Science.gov (United States)

2012-03-01

fall-2006/lecture-notes/lect11.pdf Chang, C.-T. (2005). A Linearization Approach for Inventory Models with Variable Lead Time. International Journal of Production Economics , 263...Demand and Lead Time are Stochastic. International Journal of Production Economics , 595-605. Hayya, J. C., Harrison, T. P., & He, X. (2011). The Impact

The Development of Self-Definition and Relatedness in Emerging Adulthood and Their Role in the Development of Depressive Symptoms

Science.gov (United States)

Kopala-Sibley, Daniel C.; Zuroff, David C.; Hermanto, Nicola; Joyal-Desmarais, Keven

2016-01-01

According to Blatt (2004; Blatt & Luyten, 2009) and others (e.g., Beck, Epstein, Harrison, & Emery, 1983), establishing positive self-definition and mature relatedness to others represent core lifespan developmental tasks. In a sample of emerging adults, this study examined the effects of the quality of one close friendship and changes in…

The Relationship between Student Leaders' Constructive Development, Their Leadership Identity, and Their Understanding of Leadership

Science.gov (United States)

Sessa, Valerie I.; Ploskonka, Jillian; Alvarez, Elphys L.; Dourdis, Steven; Dixon, Christopher; Bragger, Jennifer D.

2016-01-01

The purpose of our research was to use Day, Harrison, and Halpin's, (2009) theory of leadership development as a premise to investigate how students' constructive development is related to their leader identity development and understanding of leadership. Baxter Magolda's Model of Epistemological Reflection (MER, 1988, 2001) was used to understand…

Covert Action Lead -- Central Intelligence Agency or Special Forces

Science.gov (United States)

2007-05-01

designed, people will blame the action on the wrong party (the enemy). Thus, public opinion will be won over to the side that actually did the killing ...mountain warfare. The FSSF training was conducted at Fort William Henry Harrison in Helena, Montana. The FSSF was activated for Project Plough , which

76 FR 21092 - Notice of Projects Approved or Rescinded for Consumptive Uses of Water

Science.gov (United States)

2011-04-14

.... 46. Anadarko E&P Company LP, Pad ID: Harry W Stryker Pad A, ABR- 201011044, Cogan House Township... Energy, LLC, Pad ID: Triana-Young Pad B, ABR-201012008, Hector Township, Potter County, Pa.; Consumptive...- 20100346, Harrison Township, Potter County, Pa.; Consumptive Use of up 4.000 mgd; Rescinded Date: December...

The Effects of Paternalism Upon an Industrial Community's Participation in Schooling.

Science.gov (United States)

Desmond, Cheryl T.

The influence of paternalism upon a community's school district participation is discussed in this historical case study. Interviews and historical research explore the impact of the "welfare capitalism" of the Endicott Shoe Corporation and International Business Machines on Harrison City, New York, from 1890 through the present. An analysis of…

Chikungunya: an overview

Indian Academy of Sciences (India)

PRAKASH KUMAR

by a number of outbreaks in Cambodia, Vietnam, Malaysia,. Taiwan etc. in the subsequent years. In the Bangkok epidemic, though three etiological agents were .... cell culture based formalin inactivated vaccine developed by. Harrison et al (1971) was the most promising as it elicited high levels of neutralizing antibody in ...

40 CFR 52.2522 - Approval status.

Science.gov (United States)

2010-07-01

... plant, Monongahela Power Co. (b) The Administrator hereby extends the interim limitation of 5.12 lbs. SO2 per million BTU for the Harrison power plant until a permanent emission limitation is approved. (c...-10 NAAQS. (h) EPA disapproves the portion of 45 CSR 13 subsection 1 referencing major stationary...

Kohalejõudmise kõrvaltee : graafikatriennaal / Lucy Harrison ; interv. Anneli Porri

Index Scriptorium Estoniae

Harrison, Lucy

2004-01-01

Intervjuu Lucy Harrisoniga, kes esineb Tallinna XIII graafikatriennaalil tekstikogumikuga "Fantastilised linnad" ja kellel ilmus koostöös Christiane Baumgartneriga raamat "Detour", kus kunstnikud püüavad kahe turistidele mõeldud nõukogudeaegse linnagiidi abil ühitada seal antud kirjeldust Tallinna tegelikkusega

Individual Differences in the Attribution of Incentive Salience to a Pavlovian Alcohol Cue

Science.gov (United States)

Villaruel, Franz R.; Chaudhri, Nadia

2016-01-01

Individual differences exist in the attribution of incentive salience to conditioned stimuli associated with food. Here, we investigated whether individual differences also manifested with a Pavlovian alcohol conditioned stimulus (CS). We compiled data from five experiments that used a Pavlovian autoshaping paradigm and tests of conditioned reinforcement. In all experiments, male, Long-Evans rats with unrestricted access to food and water were acclimated to 15% ethanol. Next, rats received Pavlovian autoshaping training, in which a 10 s presentation of a retractable lever served as the CS and 0.2 mL of 15% ethanol served as the unconditioned stimulus (US). Finally, rats underwent conditioned reinforcement tests in which nose-pokes to an active aperture led to brief presentations of the lever-CS, but nose-pokes to an inactive aperture had no consequence. Rats were categorized as sign-trackers, goal-trackers and intermediates based on a response bias score that reflected their tendencies to sign-track or goal-track at different times during training. We found that distinct groups of rats either consistently interacted with the lever-CS (“sign-trackers”) or routinely approached the port during the lever-CS (“goal-trackers”) across a majority of the training sessions. However, some individuals (“shifted sign-trackers”) with an early tendency to goal-track later shifted to comparable asymptotic levels of sign-tracking as the group identified as sign-trackers. The lever-CS functioned as a conditioned reinforcer for sign-trackers and shifted sign-trackers, but not for goal-trackers. These results provide evidence of robust individual differences in the extent to which a Pavlovian alcohol cue gains incentive salience and functions as a conditioned reinforcer. PMID:28082877

Individual Differences in the Attribution of Incentive Salience to a Pavlovian Alcohol Cue.

Science.gov (United States)

Villaruel, Franz R; Chaudhri, Nadia

2016-01-01

Individual differences exist in the attribution of incentive salience to conditioned stimuli associated with food. Here, we investigated whether individual differences also manifested with a Pavlovian alcohol conditioned stimulus (CS). We compiled data from five experiments that used a Pavlovian autoshaping paradigm and tests of conditioned reinforcement. In all experiments, male, Long-Evans rats with unrestricted access to food and water were acclimated to 15% ethanol. Next, rats received Pavlovian autoshaping training, in which a 10 s presentation of a retractable lever served as the CS and 0.2 mL of 15% ethanol served as the unconditioned stimulus (US). Finally, rats underwent conditioned reinforcement tests in which nose-pokes to an active aperture led to brief presentations of the lever-CS, but nose-pokes to an inactive aperture had no consequence. Rats were categorized as sign-trackers, goal-trackers and intermediates based on a response bias score that reflected their tendencies to sign-track or goal-track at different times during training. We found that distinct groups of rats either consistently interacted with the lever-CS ("sign-trackers") or routinely approached the port during the lever-CS ("goal-trackers") across a majority of the training sessions. However, some individuals ("shifted sign-trackers") with an early tendency to goal-track later shifted to comparable asymptotic levels of sign-tracking as the group identified as sign-trackers. The lever-CS functioned as a conditioned reinforcer for sign-trackers and shifted sign-trackers, but not for goal-trackers. These results provide evidence of robust individual differences in the extent to which a Pavlovian alcohol cue gains incentive salience and functions as a conditioned reinforcer.

Autoshaping i.v. cocaine self-administration in rats: effects of nondrug alternative reinforcers on acquisition.

Science.gov (United States)

Carroll, M E; Lac, S T

1993-01-01

The purpose of this experiment was to examine the effects of a nondrug alternative reinforcer and feeding conditions on the acquisition of cocaine self-administration. Rats were autoshaped to press a lever that resulted in a 0.2 mg/kg i.v. cocaine infusion. Responses on the lever were monitored during six consecutive autoshaping sessions that occurred each day. A retractable lever was inserted into the operant chamber on a random time 60 s schedule 10 times per session for six sessions that began each hour. Each day the six autoshaping sessions were followed by a 6-h cocaine self-administration session. During self-administration the lever remained extended, and each response on the lever resulted in a cocaine infusion (0.2 mg/kg). The criterion for acquisition of cocaine-reinforced behavior was met when there were 5 consecutive days during which the mean number of infusions during the 6-h self-administration session was at least 100. This procedure was repeated daily until the criterion was met or 30 days elapsed. The rats were also trained to respond on lick-operated automatic drinking devices that delivered 0.05 ml water or a glucose and saccharin solution (G + S) contingent upon each lick response. Five groups of 12-14 rats were compared. The first four groups constituted a 2 x 2 factorial design whereby either G + S or water was available in the home cage for 3 weeks before autoshaping began and G + S or water was available in the operant chamber during autoshaping. These groups were limited to 20 g food per day and all had free access to water.(ABSTRACT TRUNCATED AT 250 WORDS)

Enhancement of a visual reinforcer by D-amphetamine and nicotine in adult rats: relation to habituation and food restriction.

Science.gov (United States)

Wright, Jennifer M; Ren, Suelynn; Constantin, Annie; Clarke, Paul B S

2018-03-01

Nicotine and D-amphetamine can strengthen reinforcing effects of unconditioned visual stimuli. We investigated whether these reinforcement-enhancing effects reflect a slowing of stimulus habituation and depend on food restriction. Adult male rats pressed an active lever to illuminate a cue light during daily 60-min sessions. Depending on the experiment, rats were challenged with fixed or varying doses of D-amphetamine (0.25-2 mg/kg IP) and nicotine (0.025-0.2 mg/kg SC) or with the tobacco constituent norharman (0.03-10 μg/kg IV). Experiment 1 tested for possible reinforcement-enhancing effects of D-amphetamine and norharman. Experiment 2 investigated whether nicotine and amphetamine inhibited the spontaneous within-session decline in lever pressing. Experiment 3 assessed the effects of food restriction. Amphetamine (0.25-1 mg/kg) and nicotine (0.1 mg/kg) increased active lever pressing specifically (two- to threefold increase). The highest doses of nicotine and amphetamine also affected inactive lever responding (increase and decrease, respectively). With the visual reinforcer omitted, responding was largely extinguished. Neither drug appeared to slow habituation, as assessed by the within-session decline in lever pressing, and reinforcement-enhancing effects still occurred if the drugs were given after this decline had occurred. Food restriction enhanced the reinforcement-enhancing effect of amphetamine but not that of nicotine. Responding remained goal-directed after several weeks of testing. Low doses of D-amphetamine and nicotine produced reinforcement enhancement even in free-feeding subjects, independent of the spontaneous within-session decline in responding. Reinforcement enhancement by amphetamine, but not nicotine, was enhanced by concurrent subchronic food restriction.

Cognitive judgment bias interacts with risk based decision making and sensitivity to dopaminergic challenge in rats

Directory of Open Access Journals (Sweden)

Robert Drozd

2016-08-01

Full Text Available Although cognitive theory has implicated judgement bias in various psychopathologies, its role in decision making under risk remains relatively unexplored. In the present study we assessed the effects of cognitive judgment bias on risky choices in rats. First, we trained and tested the animals on the rat version of the probability-discounting task. During discrete trials, the rats chose between two levers; a press on the ‘small/certain’ lever always resulted in the delivery of one reward pellet, whereas a press on the ‘large/risky’ lever resulted in the delivery of four pellets. However, the probability of receiving a reward from the ‘large/risky’ lever gradually decreased over the four trial blocks. Subsequently, the rats were re-trained and evaluated on a series of ambiguous-cue interpretation tests, which permitted their classification according to the display of ‘optimistic’ or ‘pessimistic’ traits. Because dopamine has been implicated in both: risky choices and optimism, in the last experiment, we compared the reactivity of the dopaminergic system in the ‘optimistic’ and ‘pessimistic’ animals using the apomorphine (2mg/kg s.c. sensitivity test. We demonstrated that as risk increased, the proportion of risky lever choices decreased significantly slower in ‘optimists’ compared with ‘pessimists’ and that these differences between the two groups of rats were associated with different levels of dopaminergic system reactivity. Our findings suggest that cognitive judgement bias, risky decision-making and dopamine are linked, and they provide a foundation for further investigation of the behavioural traits and cognitive processes that influence risky choices in animal models.

Performance comparison of a novel configuration of beta-type Stirling engines with rhombic drive engine

International Nuclear Information System (INIS)

Solmaz, Hamit; Karabulut, Halit

2014-01-01

Highlights: • The paper describes a novel arrangement of a beta-type Stirling engine. • Its performance was compared with rhombic drive engine. • The power output of the engine was found to be greater than rhombic drive. • Efficiency was found to be higher than rhombic drive at the same working fluid mass. • Efficiency was found to be lower than rhombic drive at the same charge pressure. - Abstract: This study presents a beta type Stirling engine mechanism and its performance analysis. The displacer motion of the engine is performed by a lever mechanism. The performance of the engine was investigated via comparing with a rhombic-drive engine possessing an equal sided rhombic. Comparison was made for kinematic behaviors, power and thermal efficiency. For comparison; the piston swept volume, the inner heat transfer area, the hot and cold end temperatures, the inner heat transfer coefficient, charge pressure and dead volumes were kept equal for both engines. As working fluid the helium was used. Thermodynamic treatments of engines were performed via the nodal analysis. The power of the lever driven engine was found to be greater than the power of the rhombic drive engine. Under the equal charge pressure, the thermal efficiency of the lever driven engine was found to be lower than the efficiency of the rhombic drive engine however, under the equal working fluid mass the thermal efficiency of the lever driven engine was found to be greater than that of the rhombic drive engine. The external volume and mass of the lever driven engine is lower than the rhombic drive engine

Applicability of MIEX(®)DOC process for organics removal from NOM laden water.

Science.gov (United States)

Karpinska, Anna M; Boaventura, Rui A R; Vilar, Vítor J P; Bilyk, Andrzej; Molczan, Marek

2013-06-01

The aim of this study was to evaluate applicability of ion exchange process for organics removal from Douro River surface water at the intake of Lever water treatment plant using magnetized ion exchange resin MIEX®. Qualitative analysis of the natural organic matter present in the surface water and prediction of its amenability to removal in conventional coagulation process were assessed. Results obtained in MIEX®DOC process kinetic batch experiments allowed determination of ion exchange efficiency in dissolved organic carbon (DOC), UV absorbing organics, and true color removal. The data were compared with the efficiencies of the conventional unit processes for organics removal at Lever WTP. MIEX®DOC process revealed to be more efficient in DOC removal than conventional treatment achieving the efficiencies in the range of 61-91 %, lowering disinfection by-products formation potential of the water. DOC removal efficiency at Lever WTP depends largely on the raw water quality and ranges from 28 % for water of moderated quality to 89 % of significantly deteriorated quality. In this work, MIEX®DOC process was also used as a reference method for the determination of contribution of anionic fraction to dissolved organic matter and selectivity of the unit processes at Lever WTP for its removal.

Discriminative stimulus properties and brain distribution of phencyclidine in rats following administration by injection and smoke inhalation

International Nuclear Information System (INIS)

Wessinger, W.D.; Martin, B.R.; Balster, R.L.

1985-01-01

Four male Sprague-Dawley rats were trained to discriminate IP injections of 3.0 mg/kg phencyclidine (PCP) from saline under a 2-lever fixed-ratio 32 schedule of food presentation. After reliable discriminative control of lever choice was established, other doses of injected PCP were tested resulting in dose-dependent increases in PCP-lever selection and dose-dependent decreases in rates of responding. When doses of PCP were administered by exposure to smoke from cigarettes containing PCP, a dose-dependent increase in PCP-lever responding was also observed. delta 9-Tetrahydrocannabinol administered via smoke exposure, up to doses which markedly suppressed response rates, did not result in PCP-appropriate responding, demonstrating the specificity of the PCP stimulus by the inhalation route. Brain levels and distribution of 3 H-PCP were determined in rats administered doses calculated to result in 50% generalization by the IP injection or smoke inhalation routes. By both routes of administration roughly equivalent brain levels were attained and the distribution was relatively even across the seven brain areas analyzed. These results demonstrate the validity of using the injection route of administration when studying PCP experimentally, in spite of the fact that PCP is abused primarily by smoking

"Beatlemania" in the General Music Classroom

Science.gov (United States)

Cardany, Audrey Berger

2012-01-01

In Geoff Edgers's biography of the Beatles, "Who Were the Beatles?", young readers learn of John Lennon, Paul McCartney, Ringo Starr, and George Harrison's youth and growth as musicians, the band's formation, and their contributions to music in popular culture. "General Music Today" columnist, Cardany provides music teachers with related music…

Influence of various acids on the physico–mechanical properties of ...

Indian Academy of Sciences (India)

of the calcium salts formed are dependent on the chemical character of anion. The acidic attack is affected by the processes of decomposition and leaching of the constituent of cement matrix (Gutt & Harrison 1997; Mehta 1986). An acidic media may achieve values under 7, predominantly 6 and lower. However, pH values ...

Identification and Pathological Characterization of Persistent Asymptomatic Ebola Virus infection in Rhesus Monkeys

Science.gov (United States)

2017-05-12

2454 (2015). 412 16. Blackley, D.J., et al. Reduced evolutionary rate in reemerged Ebola virus 413 transmission chains. Sci Adv 2, e1600378 (2016). 414...and Marburgvirus Infections. in Harrison’s Principles of 456 Internal Medicine , Vol. 2 (eds. Kasper, D.L., et al.) 1323-1329 (McGraw-Hill 457

Johan Bülows spade

DEFF Research Database (Denmark)

Knudsen, Karin Esmann

2017-01-01

practice. The paradise of the garden is the place of care (Robert Pugue Harrison 2008). This chapter examines how the ideas of vita activa (Hanna Arendt 1958) occur in the eighteenth century in 'how-to' gardening books and in the practice of the Danish garden enthusiast Johan Bülow, who created the garden...

Eventos de Agosto (August Events).

Science.gov (United States)

Toro, Leonor; Pla, Myrna

Written in Spanish, this booklet contains brief information on seven August events celebrated by Puerto Ricans: Herbert Hoover's birthdate (August 10); Acta del Seguro Social (Social Security Act, August 14); Julian E. Blanco (August 14), Enmienda 19 Sufragia de la Mujer (Amendment 19, Women's Suffrage, August 26); Benjamin Harrison (August 20);…

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences. Will D Penny. Articles written in Journal of Biosciences. Volume 32 Issue 1 January 2007 pp 129-144 Articles. Dynamic causal models of neural system dynamics: current state and future extensions · Klaas E Stephan Lee M Harrison Stefan J Kiebel Olivier David Will D Penny Karl J ...

Essays on Corporate Capital Structure

OpenAIRE

Albul, Boris

2012-01-01

This dissertation studies capital structure decisions of levered and unlevered firms using the modeling framework of Leland (1994). The first chapter, Cash Holdings and Financial Constraints, focuses on optimal management of cash holdings by equity holders of a levered, financially constrained firm. I add financial constraints as a market friction to the traditional model. A financially constrained firm is not able to issue new equity to subsidize net operating losses and is subject to pre...

Public service i netværkssamfundet

DEFF Research Database (Denmark)

Mortensen, Frands

Analyser af digitaliseringens betydning for radio, TV og Internet, og især for konsekvenserne for levering af Public Service Broadcasting. En særlig del omhandler EU's betydning for udviklingen af statsstøtte til PSB.......Analyser af digitaliseringens betydning for radio, TV og Internet, og især for konsekvenserne for levering af Public Service Broadcasting. En særlig del omhandler EU's betydning for udviklingen af statsstøtte til PSB....

Calibration Procedures in Mid Format Camera Setups

Science.gov (United States)

Pivnicka, F.; Kemper, G.; Geissler, S.

2012-07-01

A growing number of mid-format cameras are used for aerial surveying projects. To achieve a reliable and geometrically precise result also in the photogrammetric workflow, awareness on the sensitive parts is important. The use of direct referencing systems (GPS/IMU), the mounting on a stabilizing camera platform and the specific values of the mid format camera make a professional setup with various calibration and misalignment operations necessary. An important part is to have a proper camera calibration. Using aerial images over a well designed test field with 3D structures and/or different flight altitudes enable the determination of calibration values in Bingo software. It will be demonstrated how such a calibration can be performed. The direct referencing device must be mounted in a solid and reliable way to the camera. Beside the mechanical work especially in mounting the camera beside the IMU, 2 lever arms have to be measured in mm accuracy. Important are the lever arms from the GPS Antenna to the IMU's calibrated centre and also the lever arm from the IMU centre to the Camera projection centre. In fact, the measurement with a total station is not a difficult task but the definition of the right centres and the need for using rotation matrices can cause serious accuracy problems. The benefit of small and medium format cameras is that also smaller aircrafts can be used. Like that, a gyro bases stabilized platform is recommended. This causes, that the IMU must be mounted beside the camera on the stabilizer. The advantage is, that the IMU can be used to control the platform, the problematic thing is, that the IMU to GPS antenna lever arm is floating. In fact we have to deal with an additional data stream, the values of the movement of the stabiliser to correct the floating lever arm distances. If the post-processing of the GPS-IMU data by taking the floating levers into account, delivers an expected result, the lever arms between IMU and camera can be applied

75 FR 49709 - Takes of Marine Mammals Incidental to Specified Activities; Taking Marine Mammals Incidental to...

Science.gov (United States)

2010-08-13

...'s existing leases in Harrison Bay in the central Beaufort Sea. Actual locations of site clearance... 160 dB are taken. However, because of the tendency of whales to avoid the source to some degree, and... exposures would likely occur at levels closer to 160 dB (not higher levels) and the impacts would be...

Chemical and thermal properties of VIP latrine sludge

African Journals Online (AJOL)

2015-07-04

Jul 4, 2015 ... This study investigated the chemical and thermal properties of faecal sludge from 10 dry VIP latrines in Bester's Camp in the eThekwini Municipality, Durban, ... emptying and treatment equipment. A manual sorting of the pit .... (LaDePa) plant (Harrison and Wilson, 2012). Figure 3 illustrates the depths of the ...

China White

DEFF Research Database (Denmark)

Arnoldi, Jakob; Lash, Scott

2012-01-01

This article reflects on some themes in Harrison White’s work in the context of China, where the social and cultural construction of markets is quite literal. We explore how we get markets where previously there were no markets and draw on White’s central themes of ‘uncertainty’, ‘value’ and ‘order...

Initial estimates of hurricane Katrina impacts of Mississippi gulf coast forest resources

Science.gov (United States)

Patrick A. Glass; Sonja N. Oswalt

2007-01-01

Hurricane Katrina pummeled the Gulf Coast of Mississippi on August 29, 2005. The eye wall of the storm passed directly over Hancock and Pearl River Counties. Harrison, Jackson, Stone, and George Counties on the windward side of the hurricane's path sustained severe damage before the storm's strength dissipated as it moved farther inland (fig. 1).

Multifilter Rotating Shadowband Radiometer (MFRSR) Handbook

Energy Technology Data Exchange (ETDEWEB)

Hodges, GB; Michalsky, JJ

2011-02-07

The visible Multifilter Rotating Shadowband Radiometer (MFRSR) is a passive instrument that measures global and diffuse components of solar irradiance at six narrowband channels and one open, or broadband, channel (Harrison et al. 1994). Direct irradiance is not a primary measurement, but is calculated using the diffuse and global measurements. To collect one data record, the MFRSR takes measurements at four different shadowband positions. The first measurement is taken with the shadowband in the nadir (home) position. The next three measurements are, in order, the first side-band, sun-blocked, and second side-band. The side-band measurements are used to correct for the portion of the sky obscured by the shadowband. The nominal wavelengths of the narrowband channels are 415, 500, 615, 673, 870, and 940 nm. From such measurements, one may infer the atmosphere's aerosol optical depth at each wavelength. In turn, these optical depths may be used to derive information about the column abundances of ozone and water vapor (Michalsky et al. 1995), as well as aerosol (Harrison and Michalsky 1994) and other atmospheric constituents.

Multifilter Rotating Shadowband Radiometer (MFRSR) Handbook With subsections for derivative instruments: Multifilter Radiometer (MFR) Normal Incidence Multifilter Radiometer (NIMFR)

Energy Technology Data Exchange (ETDEWEB)

Hodges, Gary B. [National Oceanic and Atmospheric Administration (NOAA), Boulder, CO (United States). Earth System Research Lab.; Michalsky, Joseph J. [National Oceanic and Atmospheric Administration (NOAA), Boulder, CO (United States). Earth System Research Lab.

2016-03-01

The visible Multifilter Rotating Shadowband Radiometer (MFRSR) is a passive instrument that measures global and diffuse components of solar irradiance at six narrowband channels and one open, or broadband, channel (Harrison et al. 1994). Direct irradiance is not a primary measurement, but is calculated using diffuse and global measurements. To collect one data record, the MFRSR takes measurements at four different shadowband positions. The first measurement is taken with the shadowband in the nadir (home) position. The next three measurements are, in order, the first side-band, sun-blocked, and second side-band. The side-band measurements are used to correct for the portion of the sky obscured by the shadowband. The nominal wavelengths of the narrowband channels are 415, 500, 615, 673, 870, and 940 nm. From such measurements, one may infer the atmosphere’s aerosol optical depth at each wavelength. In turn, these optical depths may be used to derive information about the column abundances of ozone and water vapor (Michalsky et al. 1995), as well as aerosol (Harrison and Michalsky 1994) and other atmospheric constituents.

Limitations to the Generality of Cocaine Locomotor Sensitization

OpenAIRE

Marusich, Julie A.; Branch, Marc N.; Dallery, Jesse

2008-01-01

Repeated exposure to cocaine often leads to tolerance to effects on operant behavior, whereas sensitization often develops to effects on locomotor activity. The purpose of the present set of experiments was to examine if locomotor sensitization to cocaine would develop in the presence or absence of an operant contingency in rats. In Experiment 1, rats lever pressed on an FR schedule of reinforcement, and were administered chronic cocaine. Tolerance to effects of cocaine on lever pressing deve...

Insulin sensitivity of hepatic glucose and lipid metabolism in animal models of hepatic steatosis

OpenAIRE

Grefhorst, Aldo

2006-01-01

De lever is betrokken bij de regulatie van zowel het koolhydraat als het vet metabolisme. De lever slaat glucose op als glycogeen, scheidt glucose uit, kan glucose maken uit bijvoorbeeld melkzuur en aminozuren (‘gluconeogenese’), zet glucose om in vet (‘de novo lipogenese’), verbrandt vetzuren in de beta-oxidatie (levert energie voor de gluconeogenese) en scheidt triglycerides uit in de circulatie in ‘very low density lipoprotein’ (VLDL) deeltjes. Insuline remt de glucoseproductie door de lev...

Remotely operated closure device for a pipeline with a fixed pipeline flange. Fernbedient betaetigbare Verschlussvorrichtung fuer eine Rohrleitung mit ortsfestem Rohrleitungsflansch

Energy Technology Data Exchange (ETDEWEB)

Westendorf, H.

1987-01-29

The remotely operated closure is set by suspension centring on the circumference of a blank flange on the fixed pipeline flange to be closed. By operating a central actuating mechanism at the closure, the clamping levers are adjusted so that the blank flange is clamped to the pipeline flange and the two flanges are pressed together. The spring-loaded clamping levers are particularly suitable for actuating the closure with the pliers of a manipulator of a large cell.

Mounting clips for panel installation

Science.gov (United States)

Cavieres, Andres; Al-Haddad, Tristan; Goodman, Joseph; Valdes, Francisco

2017-02-14

An exemplary mounting clip for removably attaching panels to a supporting structure comprises a base, spring locking clips, a lateral flange, a lever flange, and a spring bonding pad. The spring locking clips extend upwardly from the base. The lateral flange extends upwardly from a first side of the base. The lateral flange comprises a slot having an opening configured to receive at least a portion of one of the one or more panels. The lever flange extends outwardly from the lateral flange. The spring bonding flange extends downwardly from the lever flange. At least a portion of the first spring bonding flange comprises a serrated edge for gouging at least a portion of the one or more panels when the one or more panels are attached to the mounting clip to electrically and mechanically couple the one or more panels to the mounting clip.

Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences.

Directory of Open Access Journals (Sweden)

Patrick A Randall

Full Text Available Mesolimbic dopamine (DA is involved in behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response requirements, and instead select less effortful food-seeking behaviors. In the present study, the effects of several drug treatments were assessed using a progressive ratio (PROG/chow feeding concurrent choice task. With this task, rats can lever press on a PROG schedule reinforced by a preferred high-carbohydrate food pellet, or alternatively approach and consume the less-preferred but concurrently available laboratory chow. Rats pass through each ratio level 15 times, after which the ratio requirement is incremented by one additional response. The DA D(2 antagonist haloperidol (0.025-0.1 mg/kg reduced number of lever presses and highest ratio achieved but did not reduce chow intake. In contrast, the adenosine A(2A antagonist MSX-3 increased lever presses and highest ratio achieved, but decreased chow consumption. The cannabinoid CB1 inverse agonist and putative appetite suppressant AM251 decreased lever presses, highest ratio achieved, and chow intake; this effect was similar to that produced by pre-feeding. Furthermore, DA-related signal transduction activity (pDARPP-32(Thr34 expression was greater in nucleus accumbens core of high responders (rats with high lever pressing output compared to low responders. Thus, the effects of DA antagonism differed greatly from those produced by pre-feeding or reduced CB1 transmission, and it appears unlikely that haloperidol reduces PROG responding because of a general reduction in primary food motivation or the unconditioned reinforcing properties of food. Furthermore, accumbens core signal transduction activity is related to individual differences in work output.

Effects of ethanol on Pavlovian autoshaping in rats.

Science.gov (United States)

Tomie, A; Cunha, C; Mosakowski, E M; Quartarolo, N M; Pohorecky, L A; Benjamin, D

1998-09-01

Approach responses, consummatory behaviors, and directed motor responses maintained by food reward resemble autoshaping CRs and are increased by lower doses of ethanol. This study evaluated the effects of presession i.p. injections of ethanol doses (0.00, 0.25, 0.50, 0.70. or 1.00 g/kg) on the acquisition of lever-press autoshaping CR performance in groups of male Long-Evans hooded rats. Paired groups received 15 daily sessions of Pavlovian autoshaping procedures, wherein the insertion of a retractable lever for 5 s (CS) was followed by the response-independent presentation of food (US). Ethanol facilitated lever-press autoshaping CR acquisition, as revealed by dose-related increases in the number of trials on which CRs were performed. The form of the dose-effect curve was inverted U-shaped with maximal responding induced during sessions 1-5 by the 0.70 g/kg ethanol dose. A similar dose-effect curve was observed during sessions 11-15, revealing that the effects of ethanol on autoshaping CR performance were relatively stable. A pseudoconditioning control group injected presession with 0.50 g/kg ethanol received training wherein the food US was presented randomly with respect to the lever CS. Few lever-presses were performed by the Random 0.50 group, indicating that ethanol's effects on autoshaping CR acquisition and maintenance observed in the Paired 0.50 group were not due to its psychomotor activating effects. A non-injection control group performed more autoshaping CRs than did the control group injected presession with saline, indicating that daily presession i.p. injections per se suppress autoshaping CR performance. Results reveal that low doses of ethanol enhance Pavlovian conditioning of directed motor and consummatory-like responding maintained by food reward. Implications for autoshaping accounts of impulsivity and drug abuse are considered.

Preference pulses and the win-stay, fix-and-sample model of choice.

Science.gov (United States)

Hachiga, Yosuke; Sakagami, Takayuki; Silberberg, Alan

2015-11-01

Two groups of six rats each were trained to respond to two levers for a food reinforcer. One group was trained on concurrent variable-ratio 20 extinction schedules of reinforcement. The second group was trained on a concurrent variable-interval 27-s extinction schedule. In both groups, lever-schedule assignments changed randomly following reinforcement; a light cued the lever providing the next reinforcer. In the next condition, the light cue was removed and reinforcer assignment strictly alternated between levers. The next two conditions redetermined, in order, the first two conditions. Preference pulses, defined as a tendency for relative response rate to decline to the just-reinforced alternative with time since reinforcement, only appeared during the extinction schedule. Although the pulse's functional form was well described by a reinforcer-induction equation, there was a large residual between actual data and a pulse-as-artifact simulation (McLean, Grace, Pitts, & Hughes, 2014) used to discern reinforcer-dependent contributions to pulsing. However, if that simulation was modified to include a win-stay tendency (a propensity to stay on the just-reinforced alternative), the residual was greatly reduced. Additional modifications of the parameter values of the pulse-as-artifact simulation enabled it to accommodate the present results as well as those it originally accommodated. In its revised form, this simulation was used to create a model that describes response runs to the preferred alternative as terminating probabilistically, and runs to the unpreferred alternative as punctate with occasional perseverative response runs. After reinforcement, choices are modeled as returning briefly to the lever location that had been just reinforced. This win-stay propensity is hypothesized as due to reinforcer induction. © Society for the Experimental Analysis of Behavior.

1.5 °C ? - Solutions for avoiding catastrophic climate change in this century

Science.gov (United States)

Xu, Y.

2017-12-01

The historic Paris Agreement calls for limiting global temperature rise to "well below 2 °C." Because of uncertainties in emission scenarios, climate, and carbon cycle feedback, we interpret the Paris Agreement in terms of three climate risk categories and bring in considerations of low-probability (5%) high impact (LPHI) warming in addition to the central (˜50% probability) value. The current risk category of dangerous warming is extended to more categories, which are defined by us here as follows: >1.5 °C as dangerous; >3 °C as catastrophic; and >5 °C as unknown, implying beyond catastrophic, including existential threats. With unchecked emissions, the central warming can reach the dangerous level within three decades, with the LPHI warming becoming catastrophic by 2050. We outline a three-lever strategy to limit the central warming below the dangerous level and the LPHI below the catastrophic level, both in the near term (pollutant (SP) lever to mitigate short-lived climate pollutants, and the carbon extraction and sequestration (CES) lever to thin the atmospheric CO2 blanket. Pulling on both CN and SP levers and bending the emissions curve by 2020 can keep the central warming below dangerous levels. To limit the LPHI warming below dangerous levels, the CES lever must be pulled as well to extract as much as 1 trillion tons of CO2 before 2100 to both limit the preindustrial to 2100 cumulative net CO2 emissions to 2.2 trillion tons and bend the warming curve to a cooling trend. In addition to present the analysis above, I will also share (1) perspective on developed and developing world actions and interactions on climate solutions; (2) Prof V. Ramanathan's interactions with the Pontifical Academy of Sciences and other religious groups which are highly valuable to the interdisciplinary audience.

"As false as the Black Prince of Hades": resurveying in Arkansas, 1849-1859

Science.gov (United States)

Don C. Bragg; Tom Webb

2014-01-01

In April 1856, a surveyor named Granville McPherson, toiling in the rugged hills north of present-day Harrison, Arkansas, was growing increasingly frustrated. The source of his aggravation was a deeply flawed original land survey filed by one of his predecessors, Charles H. Pelham. Years earlier, Pelham had sworn under oath that he had faithfully executed an original...

Space and Time in Life and Science

Indian Academy of Sciences (India)

Srimath

From this, to m y thinking, the G reeks learned ... scienti¯c and technological progress has required ever- ... In the history of clockmakers, the name of the great horologist John Harrison (1693{ ..... B ut from very early tim es people w ere ..... contrast, a linear theory like Maxwell's equations for the electromagnetic ¯eld could ...

Børnebogsforfatteren i det litteraturpædagogiske arbejde

DEFF Research Database (Denmark)

Ingerslev, Gitte Holten

2011-01-01

. Fairy tales teach that a devalued person may come to be valued, that danger has to be faced and dealt with, and most importantly of all that the fears that seep into your dreams at night and that hide in the dark shadows under our beds can be conquered. [1] (Harrison, 2008) (Læsning er vigtig fordi du...

Piits, kaabu ja kulunud nahkjakk / Laurence Lumiere, Jaanus Noormets

Index Scriptorium Estoniae

Lumiere, Laurence

2008-01-01

Cannes'i festivalil esilinastus Steven Spielbergi järjekordne (arvult neljas) Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull"). Viimase filmi sünnist, varasemate filmide lühikokkuvõtted, näitlejad, kes on seda rolli mänginud eri elujärkudes ja seriaalides

Workplace Stressors and Musculoskeletal Symptoms: Examining the Combined Impact of Ergonomic and Work Organization Factors

Science.gov (United States)

2001-04-10

those by Karasek (1979, 1985), Karasek and Theorell (1990), and Rubenowitz (1984, 1997) were the most frequently referenced. Other measurement tools...demands, interpersonal relations, technology, and physical exposures (e.g., French, Caplan & van Harrison, 1982; Karasek & Theorell , 1990; Smith...comparative assessments of psychosocial job characteristics. Journal of Occupational Health Psychology, ;!, 322-355. Karasek R & Theorell T (1990

Air & Space Power Journal. Volume 29, Number 2, March-April 2015

Science.gov (United States)

2015-04-01

combine authority and responsibility with accountability for performance at every level . Merrill A. McPeak, Selected Works, 1990– 1994 (Maxwell AFB...In this regard, I believe that Harrison succeeds. He begins by delivering an excellent historical account of the defini- tions of strategy...Reviewer: Capt Ian S. Bertram, USAF Rudder: From Leader to Legend . . . . . . . . . . . . . . . . . . . . . . . . . . 172

Despite being known as the Wild Coast, owing to its rough seas and ...

African Journals Online (AJOL)

spamer

Despite being known as the Wild Coast, owing to its rough seas and ...... prognosis for the skiboat fishery is not good. Com- ... from the Margate/Port Edward area, as well as Messrs. G. Meyers from ... FIELDING, P. J., ROBERTSON, W. D., DYE, A. H., TOMALIN, ... HARRISON, T. D., COOPER, J. A. G. and A. E. L. RAMM 2000.

A comparison of Lewis and Fischer rat strains on autoshaping (sign-tracking), discrimination reversal learning and negative auto-maintenance.

Science.gov (United States)

Kearns, David N; Gomez-Serrano, Maria A; Weiss, Stanley J; Riley, Anthony L

2006-05-15

Lewis (LEW) and Fischer (F344) rat strains differ on a number of physiological characteristics, such as hypothalamic-pituitary-adrenal (HPA) axis activity, as well as on behavioral tasks, including those that measure impulsivity and drug reward. Since autoshaping, the phenomenon where animals approach and contact reward-paired conditioned stimuli, has been linked to HPA axis functioning, impulsivity and drug taking, the present study compared LEW and F344 rats on the rate of acquisition and performance of the autoshaping response. Rats were trained on an autoshaping procedure where insertions of one retractable lever (CS(+)) were paired response-independently with food, while insertions of another lever (CS(-)) were not paired with food. LEW rats acquired the autoshaping response more rapidly and also performed the autoshaping response at a higher rate than F344 rats. No differences between the strains were observed when rats were trained on a discrimination reversal where the CS(+) and CS(-) levers were reversed or during a negative auto-maintenance phase where CS(+) lever contacts cancelled food delivery. Potential physiological mechanisms that might mediate the present results, including strain differences in HPA axis and monoamine neurotransmitter activity, are discussed. The finding that LEW (as compared to F344 rats) more readily acquire autoshaping and perform more responses is consistent with research indicating that LEW rats behave more impulsively and more readily self-administer drugs of abuse.

Remotely operated closure device for a pipeline with a fixed pipeline flange

International Nuclear Information System (INIS)

Westendorf, H.

1987-01-01

The remotely operated closure is set by suspension centring on the circumference of a blank flange on the fixed pipeline flange to be closed. By operating a central actuating mechanism at the closure, the clamping levers are adjusted so that the blank flange is clamped to the pipeline flange and the two flanges are pressed together. The spring-loaded clamping levers are particularly suitable for actuating the closure with the pliers of a manipulator of a large cell. (DG) [de

Development of combined brake system on front and rear brakes for scooter; Scooter yo zenkorin rendo brake system no kaihatsu

Energy Technology Data Exchange (ETDEWEB)

Okazaki, Y; Itabashi, T; Shinohara, S; Honda, Y [Honda R and D Co. Ltd., Tokyo (Japan)

1997-10-01

Scooters need appropriate front and rear wheel braking power distribution and each of front and rear brakes have been operated using right and left levers. This time, a low cost brakes with cable type combined brake system for small size scooter and a brakes with hydraulic type combined brake system for middle size scooter have been developed to obtain appropriate front and rear wheel braking power distribution. Both systems use convenient left lever to operate. 3 refs., 9 figs., 1 tab.

À LA RECHERCHE DES FONDEMENTS CONCEPTUELS ET METHODOLOGIQUES DU BALANCED SCORECARD : LE MODELE DE KAPLAN ET NORTON REVISITÉ À TRAVERS LE CADRE CONCEPTUEL DES LEVIERS DE CONTROLE.

OpenAIRE

Gérald Naro; Denis Travaillé

2009-01-01

International audience; The aim of this paper is to confront the Balanced Scorecard (BSC) with Simons' (1995) levers of control framework and to discuss its role in the various stages of the strategic process. Whereas Kaplan and Norton present the BSC above all as a system of diagnostic control, Simons' (1995) levers of control model leads us to privilege a representation of the BSC in the form of an interactive process. Such an approach presents several theoretical and methodological implica...

Calibration of optical cantilever deflection readers

International Nuclear Information System (INIS)

Hu Zhiyu; Seeley, Tim; Kossek, Sebastian; Thundat, Thomas

2004-01-01

Because of its ultrahigh sensitivity, the optical lever detection method similar to that used in the atomic force microscope (AFM) has been widely employed as a standard technique for measuring microcantilever deflection. Along with the increasing interest in using the microcantilever as a sensing platform, there is also a requirement for a reliable calibration technique. Many researchers have used the concept of optical lever detection to construct microcantilever deflection readout instruments for chemical, physical, and biological detection. However, without an AFM piezo z scanner, it is very difficult to precisely calibrate these instruments. Here, we present a step-by-step method to conveniently calibrate an instrument using commercially available piezoresistive cantilevers. The experimental results closely match the theoretical calculation. Following this procedure, one can easily calibrate any optical cantilever deflection detection system with high reproducibility, precision, and reliability. A detailed discussion of the optical lever readout system design has been addressed in this article

Gripper driving device for moving a fuel up and down in a reactor

International Nuclear Information System (INIS)

Hatakenaka, Hideo.

1975-01-01

Object: To use a rope in one system to effect upward and downward movement of the gripper and opening and closing operation of a gripper opening and closing pawl to make the device smaller and the mechanism simpler. Structure: The device comprises two rope winding drums synchronously driven by a driving source for upward and downward movement of a gripper, a guide pulley arranged upwardly of each rope winding drum and displaced in relatively up and down opposite direction by a pawl operating portion for opening and closing the gripper, a gripper provided with a double-arm oscillating lever for suspending and supporting a rope and operating the opening and closing pawl supported within the gripper body and an actuator for operating the opening and closing pawl interlocked and connected to said lever, and two ropes mounted on the double arm lever of the gripper passing over the guide pulleys from the winding drums. (Kamimura, M.)

Behavioral effects of delayed timeouts from reinforcement.

Science.gov (United States)

Byrne, Tom; Poling, Alan

2017-03-01

Timeouts are sometimes used in applied settings to reduce target responses, and in some circumstances delays are unavoidably imposed between the onset of a timeout and the offset of the response that produces it. The present study examined the effects of signaled and unsignaled timeouts in rats exposed to concurrent fixed-ratio 1 fixed-ratio 1 schedules of food delivery, where each response on one lever, the location of which changed across conditions, produced both food and a delayed 10-s timeout. Delays of 0 to 38 s were examined. Delayed timeouts often, but not always, substantially reduced the number of responses emitted on the lever that produced timeouts relative to the number emitted on the lever that did not produce timeouts. In general, greater sensitivity was observed to delayed timeouts when they were signaled. These results demonstrate that delayed timeouts, like other delayed consequences, can affect behavior, albeit less strongly than immediate consequences. © 2017 Society for the Experimental Analysis of Behavior.

CALIBRATION PROCEDURES IN MID FORMAT CAMERA SETUPS

Directory of Open Access Journals (Sweden)

F. Pivnicka

2012-07-01

Full Text Available A growing number of mid-format cameras are used for aerial surveying projects. To achieve a reliable and geometrically precise result also in the photogrammetric workflow, awareness on the sensitive parts is important. The use of direct referencing systems (GPS/IMU, the mounting on a stabilizing camera platform and the specific values of the mid format camera make a professional setup with various calibration and misalignment operations necessary. An important part is to have a proper camera calibration. Using aerial images over a well designed test field with 3D structures and/or different flight altitudes enable the determination of calibration values in Bingo software. It will be demonstrated how such a calibration can be performed. The direct referencing device must be mounted in a solid and reliable way to the camera. Beside the mechanical work especially in mounting the camera beside the IMU, 2 lever arms have to be measured in mm accuracy. Important are the lever arms from the GPS Antenna to the IMU's calibrated centre and also the lever arm from the IMU centre to the Camera projection centre. In fact, the measurement with a total station is not a difficult task but the definition of the right centres and the need for using rotation matrices can cause serious accuracy problems. The benefit of small and medium format cameras is that also smaller aircrafts can be used. Like that, a gyro bases stabilized platform is recommended. This causes, that the IMU must be mounted beside the camera on the stabilizer. The advantage is, that the IMU can be used to control the platform, the problematic thing is, that the IMU to GPS antenna lever arm is floating. In fact we have to deal with an additional data stream, the values of the movement of the stabiliser to correct the floating lever arm distances. If the post-processing of the GPS-IMU data by taking the floating levers into account, delivers an expected result, the lever arms between IMU and

Boost læringen med levende billeder

DEFF Research Database (Denmark)

Christensen, Ole

2016-01-01

Børn og unge lever i en digital virkelighed, og det er helt afgørende, at skolerne møder denne virkelighed. Medierne har nemlig både potentialet for at understøtte og udfordre den pædagogiske praksis......Børn og unge lever i en digital virkelighed, og det er helt afgørende, at skolerne møder denne virkelighed. Medierne har nemlig både potentialet for at understøtte og udfordre den pædagogiske praksis...

An elevator

Energy Technology Data Exchange (ETDEWEB)

Gusev, A.S.; Peshkov, L.P.; Rozin, M.M.; Shestov, A.G.

1983-01-01

An elevator is proposed which includes a body, a flap, a lock with a catch and a spring-loaded shut-off clamp in the form of upper and lower horizontal levers which are connected by a handle and an axle and one end of which is made in the form of an eccentric cam. The size of the eccentricity of the cam of the levers is increased toward the handle of the clamp in order to increase the operational reliability and to extend the service life.

Uurida või mitte uurida, selles on küsimus ... / Heli Müristaja

Index Scriptorium Estoniae

Müristaja, Heli

2011-01-01

MTÜ Eesti Turismihariduse Liidu 25.-26. mail toimunud turismiettevõtjate, -õpetajate ja -õppurite ühisseminarist, kus arutati , millist rolli kannavad uuringud kvaliteetsete ja jätkusuutlike turismitoodete ja -teenuste arendamisel. Välisesinejateks olid Tony Harrison Glasgow Caledonia Ülikooli Moffat Centre for Travel & Tourism Business Development vanemkonsultant Šotimaalt ja Soomest Eva Holmberg ning Kaija Lindroth Haaga-Kelia Porvoo üksusest

A Review of Ocean Models.

Science.gov (United States)

1981-01-23

amounts of new information about the 2-38 r 4, role of eddies in the overall circulation. Related studies (Harrison, 1978) are pointing to deficiencies ...assumption described earlier, we can write the TKE (see Phillips, 1977) equation as a tk2 " - U= + n-a {-’w(k +,pr ’) - (4.6a) j where k2 is the turbulence

Cell Phones and Sun Shadows: Exploring the Equation of Time

Science.gov (United States)

Madden, Sean P.

2010-01-01

For thousands of years before the invention of reliable clocks, humans measured their days by the motion of the sun. Astronomically, one day was the length of time it took for the sun to return to the same position in the sky. With the advent of precise mechanical chronometers such as Harrison's timekeepers (Sobel and Andrewes 1998), which ran at…

Academic Training Lecture | Practical Statistics for LHC Physicists: Descriptive Statistics, Probability and Likelihood | 7-9 April

CERN Multimedia

2015-01-01

Please note that our next series of Academic Training Lectures will take place on the 7, 8 and 9 April 2015   Practical Statistics for LHC Physicists: Descriptive Statistics, Probability and Likelihood, by Harrison Prosper, Floridia State University, USA. from 11.00 a.m. to 12.00 p.m. in the Council Chamber (503-1-001) https://indico.cern.ch/event/358542/

An Analytic Model for DoD Divestments

Science.gov (United States)

2015-04-30

Modernization (Research, Development, Test, & Evaluation [RDT&E], Procurement, Military Construction, Science , & Technology, and Weapons Acquisition), and...from the insurance industry as variables that impact actuarial calculations are also worth considering here. For example, as the insurer of national...initiatives (GAO-14-134). Washington, DC: Author. Hardin, G. (1968). The tragedy of the commons. Science , 162, 1243–1248. Harrison, T. (2012, August

Atomic cranks and levers control sugar ring conformations

International Nuclear Information System (INIS)

Zhang Qingmin; Lee, Gwangrog; Marszalek, Piotr E

2005-01-01

In this paper we review the conformational analysis of sugar rings placed under tension during mechanical manipulations of single polysaccharide molecules with the atomic force microscope and during steered molecular dynamics simulations. We examine the role of various chemical bonds and linkages between sugar rings in inhibiting or promoting their conformational transitions by means of external forces. Small differences in the orientation of one chemical bond on the sugar ring can produce significantly different mechanical properties at the polymer level as exemplified by two polysaccharides: cellulose, composed of β-1→4-linked D-glucose, and amylose, composed of α-1→4-linked D-glucose. In contrast to β-glucose rings, which are mechanically stable and produce simple entropic elasticity of the chain, α-glucose rings flip under tension from their chair to a boat-like structure and these transitions produce deviations of amylose elasticity from the freely jointed chain model. We also examine the deformation of two mechanically complementary 1→6-linked polysaccharides: pustulan, a β-1→6-linked glucan, and dextran, a α-1→6-linked glucan. Forced rotations about the C 5 -C 6 bonds govern the elasticity of pustulan, and complex conformational transitions that involve simultaneous C 5 -C 6 rotations and chair-boat transitions govern the elasticity of dextran. Finally, we discuss the likelihood of various conformational transitions in sugar rings in biological settings and speculate on their significance

Parallel-beams/lever electrothermal out-of-plane actuator

NARCIS (Netherlands)

Deladi, S.; Krijnen, Gijsbertus J.M.; Elwenspoek, Michael Curt

2004-01-01

We report on the design, modeling, fabrication and testing of a powerful electrothermal actuator allowing for various modes of movement and exhibiting forces large enough to be usable in a micro-tribotester. The performance of the actuator has been simulated combining numerical and analytical

Energy efficiency. Lever for the German energy transition

International Nuclear Information System (INIS)

Persem, Melanie; Roesner, Sven

2014-05-01

This document provides some key data on energy consumption in housing and public buildings, indicates the national German objectives in terms of reduction of energy consumption, of reduction of electricity consumption, of energy efficiency, and of evolution of energy consumption in housing and public buildings and in the transport sector. It gives some data related to energy saving and achievements: energy efficiency of the German economy, improvements in housing energy efficiency and insulation, financial support for low income households, reduction of energy consumption within small-medium enterprises, the public sector, the data processing sector and public lighting, and energy saving potential by renewal of public buildings. It indicates the main measures and arrangements: information, support programs for enterprises, local communities and individuals. A graph illustrates a comparison of shares of household power consumption in France and in Germany

The Price Stability-Important Lever within the Economy

Directory of Open Access Journals (Sweden)

Maria Mirabela Florea Ianc

2016-01-01

Full Text Available One of the biggest problems that have confronted the authorities, whether fiscal, monetary, either along the time is represented by the generalised increase in prices (inflation, which is why it is not considered good at the level of an economy, because it is presented as a nominal increase of PIB, namely the erosion of the economy as a whole, not least, to generate macroeconomic imbalances The inflation creates pressure not only on monetary plan, and the plan as general economic, political and social. This, in addition to generating a sharp decline in savings, discourages investment and favors moving the capital in assets that generate real revenue.

Paddys Run Streambank Stabilization Project at the Fernald Preserve, Harrison, OH

Energy Technology Data Exchange (ETDEWEB)

Hooten, Gwendolyn [Dept. of Energy (DOE), Legacy Management; Hertel, Bill [Navarro Research and Engineering; Homer, John [Navarro Research and Engineering

2016-03-01

The Fernald Preserve is a former uranium-processing plant that underwent extensive remediation pursuant to CERCLA and is now managed by the US DOE Office of Legacy Management. While remediation of buildings and soil contamination was completed in 2006, aquifer remediation is ongoing. Paddys Run is a second-order stream that runs to the south along the western side of the Fernald Preserve. The Paddys Run watershed encompasses nearly 41 km2 (16 mi2), including most of the Fernald site. Field personnel conducting routine site inspections in March 2014 observed that Paddys Run was migrating east via bank erosion into the “Pit 3 Swale,” an area of known surface-water contamination. The soil there was certified pursuant to site regulatory agreements and meets all final remediation levels. However, weekly surface-water monitoring is conducted from two puddles within the swale area, when water that exceeds the final remediation levels is present. Paddys Run had migrated east approximately 4 m (13 ft) in 2 years and was approximately 29 m (95 ft) from the sample location. This rapid migration threatened existing conditions that allowed for continued monitoring of the swale area and also threatened Paddys Run water quality. Therefore, DOE and regulators determined that the east bank of Paddys Run required stabilization. This was accomplished with a design that included the following components: relocation of approximately 145 m (475 ft) of streambed 9 m (30 ft) west, installation of a rock toe along the east bank, installation of two cross-vane in-stream grade-control structures, stabilization of a portion of the east bank using soil encapsulated lifts, and regrading, seeding, and planting within remaining disturbed areas. In an effort to take advantage of low-flow conditions in Paddys Run, construction was initiated in September 2014. Weather delays and subsurface flow within the Paddys Run streambed resulted in an interim shutdown of the project area in December 2014. Construction activities resumed in April 2015, with completion in November 2015. To date, this stabilization project has been successful. The regraded bank and streambed have remained stable, and no compromise to installed cross-vanes, the rock toe, or the soil encapsulated lifts has been observed.

Det menneskelige skelet på prosa

DEFF Research Database (Denmark)

Svendsen, Erik

2016-01-01

Agota Kristofs romaner om børn af en borgerkrig er hverken forførende eller elegant, men gennemsigtig og gribende. Og selv om den ikke lever op til hans egne vante kriterier for yndlingslæsning, har vor anmelder aldrig kunnet slippe den.......Agota Kristofs romaner om børn af en borgerkrig er hverken forførende eller elegant, men gennemsigtig og gribende. Og selv om den ikke lever op til hans egne vante kriterier for yndlingslæsning, har vor anmelder aldrig kunnet slippe den....

Photoelastic analysis of stress distribution in oral rehabilitation.

Science.gov (United States)

Turcio, Karina Helga Leal; Goiato, Marcelo Coelho; Gennari Filho, Humberto; dos Santos, Daniela Micheline

2009-03-01

The purpose of this study was to present a literature review about photoelasticity, a laboratory method for evaluation of implants prosthesis behavior. Fixed or removable prostheses function as levers on supporting teeth, allowing forces to cause tooth movement if not carefully planned. Hence, during treatment planning, the dentist must be aware of the biomechanics involved and prevent movement of supporting teeth, decreasing lever-type forces generated by these prosthesis. Photoelastic analysis has great applicability in restorative dentistry as it allows prediction and minimization of biomechanical critical points through modifications in treatment planning.

A spider elevator

Energy Technology Data Exchange (ETDEWEB)

Butylkin, A.V.; Butylkin, V.A.; Izosimov, A.M.

1983-01-01

A spider elevator is proposed which contains a body, a wedge clamp with wedges hinged to each other, a subassembly for holding the wedge clamp in the open and closed positions and a mechanism for changing the wedge clamp, which is made in the form of levers with ears for cleats and installed in the body with the capability of turning. To increase reliability in the operational mode through using the external force for clamping the pipe, the free ends of the levers are hinged with the body by a power cylinder.

Relationships between the group-theoretic and soliton-theoretic techniques for generating stationary axisymmetric gravitational solutions

International Nuclear Information System (INIS)

Cosgrove, C.M.

1980-01-01

We investigate the precise interrelationships between several recently developed solution-generating techniques capable of generating asymptotically flat gravitational solutions with arbitrary multipole parameters. The transformations we study in detail here are the Lie groups Q and Q of Cosgrove, the Hoenselaers--Kinnersley--Xanthopoulos (HKX) transformations and their SL(2) tensor generalizations, the Neugebauer--Kramer discrete mapping, the Neugebauer Baecklund transformations I 1 and I 2 , the Harrison Baecklund transformation, and the Belinsky--Zakharov (BZ) one- and two-soliton transformations. Two particular results, among many reported here, are that the BZ soliton transformations are essentially equivalent to Harrison transformations and that the generalized HKX transformation may be deduced as a confluent double soliton transformation. Explicit algebraic expressions are given for the transforms of the Kinnersley--Chitre generating functions under all of the above transformations. In less detail, we also study the Kinnersley--Chitre β transformations, the non-null HKX transformations, and the Hilbert problems proposed independently by Belinsky and Zakharov, and Hauser and Ernst. In conclusion, we describe the nature of the exact solutions constructible in a finite number of steps with the available methods

Sex and Adolescent Ethanol Exposure Influence Pavlovian Conditioned Approach.

Science.gov (United States)

Madayag, Aric C; Stringfield, Sierra J; Reissner, Kathryn J; Boettiger, Charlotte A; Robinson, Donita L

2017-04-01

Alcohol use among adolescents is widespread and a growing concern due to long-term behavioral deficits, including altered Pavlovian behavior, that potentially contribute to addiction vulnerability. We tested the hypothesis that adolescent intermittent ethanol (AIE) exposure alters Pavlovian behavior in males and females as measured by a shift from goal-tracking to sign-tracking. Additionally, we investigated GLT-1, an astrocytic glutamate transporter, as a potential contributor to a sign-tracking phenotype. Male and female Sprague-Dawley rats were exposed to AIE (5 g/kg, intragastric) or water intermittently 2 days on and 2 days off from postnatal day (P) 25 to 54. Around P70, animals began 20 daily sessions of Pavlovian conditioned approach (PCA), where they learned that a cue predicted noncontingent reward delivery. Lever pressing indicated interaction with the cue, or sign-tracking, and receptacle entries indicated approach to the reward delivery location, or goal-tracking. To test for effects of AIE on nucleus accumbens (NAcc) excitatory signaling, we isolated membrane subfractions and measured protein levels of the glutamate transporter GLT-1 after animals completed behavior as a measure of glutamate homeostasis. Females exhibited elevated sign-tracking compared to males with significantly more lever presses, faster latency to first lever press, and greater probability to lever press in a trial. AIE significantly increased lever pressing while blunting goal-tracking, as indicated by fewer cue-evoked receptacle entries, slower latency to receptacle entry, and lower probability to enter the receptacle in a trial. No significant sex-by-exposure interactions were observed in sign- or goal-tracking metrics. Moreover, we found no significant effects of sex or exposure on membrane GLT-1 expression in the NAcc. Females exhibited enhanced sign-tracking compared to males, while AIE decreased goal-tracking compared to control exposure. Our findings support the

JPRS Report, Science and Technology, Europe.

Science.gov (United States)

1989-06-16

ESA X-Ray Observatory Described [Stephen L. Harrison, Bernd Schuerenberg; Friedrichshafen DORNIER POST, 1989] 1 SNECMA Automates Turbine Blade...environmental control system. The total value of these orders is over $500 million. The Friedrichshafen Gearwheel Factory, in cooperation with Dowty...electronic installa- tion, and the Friedrichshafen Gearwheel Factory, which has a subcontract for the complete gear box. The total value of this order is

Securing water quality and quantity: Research and development perspective

CSIR Research Space (South Africa)

Pienaar, H

2012-10-01

Full Text Available : ? economic growth & development ? human & environmental needs ? meeting international obligations ? energy needs (strategic water users) ? ensuring availability and allocation (all other users) ? CSIR 2012 Slide 3 Background ? SA 30th driest country... and quantity: Research and development perspective 4th Biennial Conference Harrison Pienaar 10 October 2012 Presentation outline ? Introduction and background to water in South Africa ? Transboundary water resource aspects ? Water related challenges...

A Chemical Characterization and Performance Study of Photodecomposed Hexanitrostilbene (HNS) and Hexanitrobibenzyl (HNBiB)

Science.gov (United States)

1989-08-01

any man-rated system, will adequately execute its life-critical function. 58 NSWC TR 90-60 REFERENCES 1. Shipp, K. C. and Kaplan , L. A., J. Org. Chem...Corvin ( MA2 ) 1 Los Angeles, CA 90009 Monsanto Research Corporation Attn: M. R. Feairheller 1 P.O. Box 32 Miamisburg, OH 45342 Ford Aerospace Corporation Attn: D. Harrison 1 3939 Fabian Way Palo Alto, CA 94303 (4)

Lie Symmetry Analysis of the Inhomogeneous Toda Lattice Equation via Semi-Discrete Exterior Calculus

International Nuclear Information System (INIS)

Liu Jiang; Wang Deng-Shan; Yin Yan-Bin

2017-01-01

In this work, the Lie point symmetries of the inhomogeneous Toda lattice equation are obtained by semi-discrete exterior calculus, which is a semi-discrete version of Harrison and Estabrook’s geometric approach. A four-dimensional Lie algebra and its one-, two- and three-dimensional subalgebras are given. Two similarity reductions of the inhomogeneous Toda lattice equation are obtained by using the symmetry vectors. (paper)

Strategic Studies Quarterly. Volume 7, Number 1, Spring 2013

Science.gov (United States)

2013-01-01

Leadership. 40. For an academic exposition of this argument, see Bruce M. Russen, Grasping the Demo- cratic Peace: Principles for a Post-ColdWar World...Kaczynski, implored major newspapers to publish his manifesto (from which, incidentally, Breivik plagiarized ) to ensure maximum expo- sure of his ideas...Paal Hilde, Malfrid Braut-Hegghammer, Keir Lieber, and Roger Harrison for excellent commentary. This research benefitted from an academic

78 FR 49403 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Determination of...

Science.gov (United States)

2013-08-14

... Federation and National Pork Producers Council, et al. v. EPA, 559 F.3d 512 (D.C. Cir. 2009). As a result of...-0067 S. Fayette 29 31 18 26 Yes. Allegheny 42-003-0093 North Park 27 26 16 23 Yes (Max Quarter). Allegheny 42-003-1008 Harrison 34 30 21 28 Yes (Max Quarter). Allegheny 42-003-1301 N. Braddock 37 34 27 33...

Assessing Victory: How to Identify the Correct Measures of Success in Counterinsurgency Warfare - The Case of the FARC in Colombia

Science.gov (United States)

2013-09-01

morphine addiction, while Europeans valued its hunger- and fatigue suppressing qualities. Famously, the original recipe for Coca - Cola included coca ...resulted in the 1914 Harrison Narcotics Tax Act, which outlawed cocaine, as well as narcotics, such as opium. Coca - Cola had already changed its formula... coca cultivators who receive protection, as well as coerced support from civilians who may prefer the Colombian Government to the insurgents, but

Cultural Resource Inventory of Lands in and Adjacent to the City of Rochester, Minnesota Flood Control Project on the South Fork Zumbro River,

Science.gov (United States)

1981-09-14

the area directly east of present- day Rochester contained fire-maintained oak openings and barrens . This area consisted of oak groves or single trees...Archaeological Survey of Lands Adjacent to the Pine River Reservoir; University of Minnesota and St. Paul District Corps of Engineers; Archaeological Field...Archaeological Field Services, Inc.; Principal Investigator. 1980 An Archaeological Reconnaissance Survey of the Harrison Hills Project, Plymouth , Hennepin

The neurosteroid pregnenolone sulfate neutralized the learning impairment induced by intrahippocampal nicotine in alcohol-drinking rats.

Science.gov (United States)

Martín-García, E; Pallarès, M

2005-01-01

The effects of intrahippocampal administration of nicotine and the neurosteroids pregnenolone sulfate and allopregnanolone on acquiring the lever-press response and extinction in a Skinner box were examined using voluntary alcohol-drinking rats. A free-choice drinking procedure that implies early availability of the alcoholic solution (10% ethanol v/v+3% glucose w/v in distilled water) was used. Alcohol and control rats were deprived of food and assigned at random to six groups. Each group received two consecutive intrahippocampal (dorsal CA1) injections immediately after 1-h of drinking ethanol and before the free lever-press response shaping and extinction session. The groups were: saline-saline; saline-pregnenolone sulfate (5 ng, 24 microM); saline-allopregnanolone (0.2 microg, 1.26 microM); nicotine (4.6 microg, 20 mM)-saline; nicotine-pregnenolone sulfate; nicotine-allopregnanolone. Blood alcohol concentrations were assessed the day before conditioning. The combination of the oral self-administration of ethanol and the intrahippocampal injection of nicotine deteriorated the ability to acquire the lever-press response. This effect was neutralized by intrahippocampal pregnenolone sulfate (negative modulator of the GABA(A) receptor complex), and it was not affected by intrahippocampal allopregnanolone (positive GABA receptor complex A modulator). Pregnenolone sulfate and allopregnanolone had no effects per se on lever-press acquisition, neither in alcohol-drinking rats nor in controls. Alcohol consumption facilitated operant extinction just as anxiolytics that act as positive modulators of the GABA receptor complex A receptors do, possibly reducing the anxiety or aversion related to non-reinforcement. This effect was increased by intrahippocampal nicotine.

Wheel-running reinforcement in free-feeding and food-deprived rats.

Science.gov (United States)

Belke, Terry W; Pierce, W David

2016-03-01

Rats experiencing sessions of 30min free access to wheel running were assigned to ad-lib and food-deprived groups, and given additional sessions of free wheel activity. Subsequently, both ad-lib and deprived rats lever pressed for 60s of wheel running on fixed ratio (FR) 1, variable ratio (VR) 3, VR 5, and VR 10 schedules, and on a response-initiated variable interval (VI) 30s schedule. Finally, the ad-lib rats were switched to food deprivation and the food-deprived rats were switched to free food, as rats continued responding on the response-initiated VI 30-s schedule. Wheel running functioned as reinforcement for both ad-lib and food-deprived rats. Food-deprived rats, however, ran faster and had higher overall lever-pressing rates than free-feeding rats. On the VR schedules, wheel-running rates positively correlated with local and overall lever pressing rates for deprived, but not ad-lib rats. On the response-initiated VI 30s schedule, wheel-running rates and lever-pressing rates changed for ad-lib rats switched to food deprivation, but not for food-deprived rats switched to free-feeding. The overall pattern of results suggested different sources of control for wheel running: intrinsic motivation, contingencies of automatic reinforcement, and food-restricted wheel running. An implication is that generalizations about operant responding for wheel running in food-deprived rats may not extend to wheel running and operant responding of free-feeding animals. Copyright © 2015 Elsevier B.V. All rights reserved.

Effects of acute administration of the GABA(B) receptor agonist baclofen on behavioral flexibility in rats.

Science.gov (United States)

Beas, B Sofia; Setlow, Barry; Bizon, Jennifer L

2016-07-01

The ability to adjust response strategies when faced with changes in the environment is critical for normal adaptive behavior. Such behavioral flexibility is compromised by experimental disruption of cortical GABAergic signaling, as well as in conditions such as schizophrenia and normal aging that are characterized by cortical hyperexcitability. The current studies were designed to determine whether stimulation of GABAergic signaling using the GABA(B) receptor agonist baclofen can facilitate behavioral flexibility. Male Fischer 344 rats were trained in a set-shifting task in which they learned to discriminate between two response levers to obtain a food reward. Correct levers were signaled in accordance with two distinct response rules (rule 1: correct lever signaled by a cue light; rule 2: correct lever signaled by its left/right position). The order of rule presentation varied, but they were always presented sequentially, with the trials and errors to reach criterion performance on the second (set shift) rule providing the measure of behavioral flexibility. Experiments determined the effects of the GABA(B) receptor agonist baclofen (intraperitoneal, 0, 1.0, 2.5, and 4.0 mg/kg) administered acutely before the shift to the second rule. Baclofen enhanced set-shifting performance. Control experiments demonstrated that this enhancement was not simply due to improved discrimination learning, nor was it due to impaired recall of the initial discrimination rule. The results demonstrate that baclofen can facilitate behavioral flexibility, suggesting that GABA(B) receptor agonists may have utility for treating behavioral dysfunction in neuropsychiatric disorders.

A novel variable delay Go/No-Go task to study attention, motivation and working memory in the head-fixed rodent.

Science.gov (United States)

Dolzani, Samuel D; Nakamura, Shinya; Cooper, Donald C

2013-01-01

In order to parse the causal elements underlying complex behaviors and decision-making processes, appropriate behavioral methods must be developed and used in concurrence with molecular, pharmacological, and electrophysiological approaches. Presented is a protocol for a novel Go/No-Go behavioral paradigm to study the brain attention and motivation/reward circuitry in awake, head-restrained rodents. This experimental setup allows: (1) Pharmacological and viral manipulation of various brain regions via targeted guide cannula; (2) Optogenetic cell-type specific activation and silencing with simultaneous electrophysiological recording and; (3) Repeated electrophysiological single and multiple unit recordings during ongoing behavior. The task consists of three components. The subject first makes an observing response by initiating a trial by lever pressing in response to distinctive Go or No-Go tones.  Then, after a variable delay period, the subject is presented with a challenge period cued by white noise during which they must respond with a lever press for the Go condition or withhold from lever pressing for the duration of the cue in the No-Go condition. After correctly responding during the challenge period (Challenge) and a brief delay, a final reward tone of the same frequency as the initiation tone is presented and sucrose reward delivery is available and contingent upon lever pressing. Here, we provide a novel procedure and validating data set that allows researchers to study and manipulate components of behavior such as attention, motivation, impulsivity, and reward-related working memory during an ongoing operant behavioral task while limiting interference from non task-related behaviors.

A novel variable delay Go/No-Go task to study attention, motivation and working memory in the head-fixed rodent [v2; ref status: indexed, http://f1000r.es/1sn

Directory of Open Access Journals (Sweden)

Samuel D Dolzani

2014-03-01

Full Text Available In order to parse the causal elements underlying complex behaviors and decision-making processes, appropriate behavioral methods must be developed and used in concurrence with molecular, pharmacological, and electrophysiological approaches. Presented is a protocol for a novel Go/No-Go behavioral paradigm to study the brain attention and motivation/reward circuitry in awake, head-restrained rodents. This experimental setup allows: (1 Pharmacological and viral manipulation of various brain regions via targeted guide cannula; (2 Optogenetic cell-type specific activation and silencing with simultaneous electrophysiological recording and; (3 Repeated electrophysiological single and multiple unit recordings during ongoing behavior. The task consists of three components. The subject first makes an observing response by initiating a trial by lever pressing in response to distinctive Go or No-Go tones.  Then, after a variable delay period, the subject is presented with a challenge period cued by white noise during which they must respond with a lever press for the Go condition or withhold from lever pressing for the duration of the cue in the No-Go condition. After correctly responding during the challenge period (Challenge and a brief delay, a final reward tone of the same frequency as the initiation tone is presented and sucrose reward delivery is available and contingent upon lever pressing. Here, we provide a novel procedure and validating data set that allows researchers to study and manipulate components of behavior such as attention, motivation, impulsivity, and reward-related working memory during an ongoing operant behavioral task while limiting interference from non task-related behaviors.

Measuring Risk Structure Using the Capital Asset Pricing Model

Directory of Open Access Journals (Sweden)

Zdeněk Konečný

2015-01-01

Full Text Available This article is aimed at proposing of an inovative method for calculating the shares of operational and financial risks. This methodological tool will support managers while monitoring the risk structure. The method is based on the capital asset pricing model (CAPM for calculation of equity cost, namely on determination of the beta coefficient, which is the only variable, that is dependent on entrepreneurial risk. There are combined both alternative approaches for calculation betas, which means, that there are accounting data used and there is distinguished unlevered beta and levered beta. The novelty of the proposed method is based on including of quantities for measuring operational and financial risks in beta calculation. The volatility of cash flow, as a quantity for measuring of operational risk, is included in the unlevered beta. Return on equity based on the cash flow and the indebtedness are variables used in calculation of the levered beta. This modification makes it possible to calculate the share of operational risk as the proportion of the unlevered/levered beta and the share of financial risk, which is the remainder of levered beta. The modified method is applied on companies from two sectors of the Czech economy. In the data set there are companies from one cyclical sector and from one neutral sector to find out potential differences in the risk structure. The findings show, that in both sectors the share of operational risk is over 50%, however, in the neutral sector is this more dominant.

Measurement of the lowest dosage of phenobarbital that can produce drug discrimination in rats

Science.gov (United States)

Overton, Donald A.; Stanwood, Gregg D.; Patel, Bhavesh N.; Pragada, Sreenivasa R.; Gordon, M. Kathleen

2009-01-01

Rationale Accurate measurement of the threshold dosage of phenobarbital that can produce drug discrimination (DD) may improve our understanding of the mechanisms and properties of such discrimination. Objectives Compare three methods for determining the threshold dosage for phenobarbital (D) versus no drug (N) DD. Methods Rats learned a D versus N DD in 2-lever operant training chambers. A titration scheme was employed to increase or decrease dosage at the end of each 18-day block of sessions depending on whether the rat had achieved criterion accuracy during the sessions just completed. Three criterion rules were employed, all based on average percent drug lever responses during initial links of the last 6 D and 6 N sessions of a block. The criteria were: D%>66 and N%50 and N%33. Two squads of rats were trained, one immediately after the other. Results All rats discriminated drug versus no drug. In most rats, dosage decreased to low levels and then oscillated near the minimum level required to maintain criterion performance. The lowest discriminated dosage significantly differed under the three criterion rules. The squad that was trained 2nd may have benefited by partially duplicating the lever choices of the previous squad. Conclusions The lowest discriminated dosage is influenced by the criterion of discriminative control that is employed, and is higher than the absolute threshold at which discrimination entirely disappears. Threshold estimations closer to absolute threshold can be obtained when criteria are employed that are permissive, and that allow rats to maintain lever preferences. PMID:19082992

Mere end marionetdukker

DEFF Research Database (Denmark)

Lehmann-Jacobsen, Emilie Tinne

2016-01-01

Pressefrihed er en mangelvare i flere sydøstasiatiske lande, og journalisterne beskrives sjældent som andet end viljeløse marionetdukker for de siddende magthavere. Det er dog langt fra den fulde fortælling. Men myten lever videre til frustration for de fagligt stolte journalister og med konsekve......Pressefrihed er en mangelvare i flere sydøstasiatiske lande, og journalisterne beskrives sjældent som andet end viljeløse marionetdukker for de siddende magthavere. Det er dog langt fra den fulde fortælling. Men myten lever videre til frustration for de fagligt stolte journalister og med...

Environmental Assessment: Grade and Pave Shoulders on Runway 15/33 Westover Air Reserve Base, MA

Science.gov (United States)

2011-11-09

advertisement in the Sunday Republican, a general circulation newspaper in this area, on 13 November 2011. The Draft EA and Draft FONSI were also provided...mid July, and Phase YG about mid July into the fall. Adding incubation and nestling periods to nest initiation dates yields an estimated period...2011, and initiation, incubation and nestling periods from Baicich and Harrison 1997, DeGraaf and Yamasaki 2001, and Maine IFW 2011. Information

The Bril (De Bril)

Science.gov (United States)

2005-11-01

instructies betreffende de uitvoering en controleert de uitvoering. 3 Standaardisatie van werkprocessen. De inhoud van bet werk is beschreven ( IKEA ...R., Bolt6, B., & Jones, D. G. (2003). Designing for Situation Awareness: An Approach to User-Centered Design . London: Taylor & Francis. Endsley, M... design of work teams. In J. W. Lorsch (Ed.), Handbook of organizational behavior (pp. 315-342). Englewood Cliffs, NJ: Prentice-Hall. Harrison, M.A. (1990

Biodegradation of Mustard

Science.gov (United States)

1994-07-01

different areas of Kuwait. The isolates were identified as Asoeraillus terreus, h. IlabirM, Mucor alobosus, usarium sp . and Penicillium citrinum (94...Thiobacillus delicatus nov. sp . J. Ferment . Technol. 54:181-191 (1976). (39) Harrison, AP. The acidophilic thiobacilli and other acidophilic bacteria...methyl sulfide is oxidized to sulfate by Hnhomicrobium S sp ., Hynhomicrobu EG (21-23), Thiobacillus thioDarus TK-m and Thiobacillus MS1 (24,25), but only

System Shock: The Archetype of Operational Shock

Science.gov (United States)

2017-05-25

the battle space. They can also facilitate a much greater understanding of the variables involved in each party’s decision - making process. However...system shock nests within current US Army Unified Land Operations doctrine. In order to test the utility of system shock theory to Gray Zone...23 Neil E. Harrison, “Thinking about the World We Make ” in Chaos Theory in the Social Sciences: Foundations and Applications

Parenting Outside the Box, Part Three: The New “Normal” | Poster

Science.gov (United States)

Editor’s Note: This article is the final installment in a series describing one NCI at Frederick parent’s perspective on special needs parenting. Part one can be found here, and part two can be found here. Parents of special-needs children do their best to help their kids thrive in typical society, but at times this can be challenging. For instance, I want my son, Harrison, to

Reduction by the positive allosteric modulator of the GABAB receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure

Directory of Open Access Journals (Sweden)

Paola Maccioni

2010-07-01

Full Text Available The present study was designed to evaluate (a alcohol self-administration behavior of selectively bred, Sardinian alcohol-preferring (sP rats exposed to the so-called “sipper” procedure (characterized by the temporal separation between alcohol-seeking and -taking phases, and (b the effect of the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in sP rats exposed to this procedure. To this end, sP rats were initially trained to lever-respond under a reinforcement requirement (RR 55 (RR55 for alcohol. Achievement of RR55 resulted in the 20-min presentation of the alcohol (15%, v/v-containing sipper bottle. Once stable levels of lever-responding and alcohol consumption were reached, rats were treated with 0, 25, 50, and 100 mg/kg GS39783 (i.g. 60 min before the self-administration session. Rats displayed robust alcohol-seeking (as suggested by relatively short latencies to the first lever-response and high frequencies of lever-responding and -taking (as suggested by alcohol intakes averaging approximately 1.5 g/kg behaviors. Pretreatment with GS39783 inhibited both alcohol-seeking (the number of rats achieving RR55 and the mean RR value were virtually halved and -taking (the amount of self-administered alcohol was reduced by approximately 60%. The results of the present study suggest the power of the “sipper” procedure in triggering high levels of alcohol-seeking and -taking behavior in sP rats. Further, these results extend to this additional procedure of alcohol self-administration the capacity of GS39783 to reduce the motivational properties of alcohol and alcohol consumption in sP rats.

Reduction by the Positive Allosteric Modulator of the GABAB Receptor, GS39783, of Alcohol Self-Administration in Sardinian Alcohol-Preferring Rats Exposed to the “Sipper” Procedure

Science.gov (United States)

Maccioni, Paola; Flore, Paolo; Carai, Mauro A. M.; Mugnaini, Claudia; Pasquini, Serena; Corelli, Federico; Gessa, Gian Luigi; Colombo, Giancarlo

2010-01-01

The present study was designed to evaluate (a) alcohol self-administration behavior of selectively bred, Sardinian alcohol-preferring (sP) rats exposed to the so-called “sipper” procedure (characterized by the temporal separation between alcohol-seeking and -taking phases), and (b) the effect of the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in sP rats exposed to this procedure. To this end, sP rats were initially trained to lever-respond under a reinforcement requirement (RR) 55 (RR55) for alcohol. Achievement of RR55 resulted in the 20-min presentation of the alcohol (15%, v/v)-containing sipper bottle. Once stable levels of lever-responding and alcohol consumption were reached, rats were treated with 0, 25, 50, and 100 mg/kg GS39783 (i.g.) 60 min before the self-administration session. Rats displayed robust alcohol-seeking (as suggested by relatively short latencies to the first lever-response and high frequencies of lever-responding) and -taking (as suggested by alcohol intakes averaging approximately 1.5 g/kg) behaviors. Pretreatment with GS39783 inhibited both alcohol-seeking (the number of rats achieving RR55 and the mean RR value were virtually halved) and -taking (the amount of self-administered alcohol was reduced by approximately 60%). The results of the present study suggest the power of the “sipper” procedure in triggering high levels of alcohol-seeking and -taking behavior in sP rats. Further, these results extend to this additional procedure of alcohol self-administration the capacity of GS39783 to reduce the motivational properties of alcohol and alcohol consumption in sP rats. PMID:21423431

The dopamine β-hydroxylase inhibitor, nepicastat, suppresses chocolate self-administration and reinstatement of chocolate seeking in rats.

Science.gov (United States)

Zaru, Alessandro; Maccioni, Paola; Colombo, Giancarlo; Gessa, Gian Luigi

2013-10-01

Craving for chocolate is a common phenomenon, which may evolve to an addictive-like behaviour and contribute to obesity. Nepicastat is a selective dopamine β-hydroxylase (DBH) inhibitor that suppresses cocaine-primed reinstatement of cocaine seeking in rats. We verified whether nepicastat was able to modify the reinforcing and motivational properties of a chocolate solution and to prevent the reinstatement of chocolate seeking in rats. Nepicastat (25, 50 and 100 mg/kg, intraperitoneal) produced a dose-related inhibition of operant self-administration of the chocolate solution in rats under fixed-ratio 10 (FR10) and progressive-ratio schedules of reinforcement, measures of the reinforcing and motivational properties of the chocolate solution, respectively. The effect of nepicastat on the reinstatement of chocolate seeking was studied in rats in which lever-responding had been extinguished by removing the chocolate solution for approximately 8 d. Nepicastat dose-dependently suppressed the reinstatement of lever-responding triggered by a 'priming' of the chocolate solution together with cues previously associated with the availability of the reward. In a separate group of food-restricted rats trained to lever-respond for regular food pellets, nepicastat reduced FR10 lever-responding with the same potency as for the chocolate solution. Spontaneous locomotor activity was not modified by nepicastat doses that reduced self-administration of the chocolate solution and regular food pellets and suppressed the reinstatement of chocolate seeking. The results indicate that nepicastat reduces motivation to food consumption sustained by appetite or palatability. Moreover, the results suggest that DBH inhibitors may be a new class of pharmacological agents potentially useful in the prevention of relapse to food seeking in human dieters.

D-Cycloserine Facilitates Reversal in an Animal Model of Post-traumatic Stress Disorder.

Science.gov (United States)

George, Sophie A; Rodriguez-Santiago, Mariana; Riley, John; Abelson, James L; Floresco, Stan B; Liberzon, Israel

2018-03-23

Many psychiatric disorders are associated with cognitive dysfunction that is ineffectively treated by existing pharmacotherapies and which may contribute to poor real-world functioning. D-cycloserine (DCS) is a partial N-methyl-D-aspartate (NMDA) agonist that has attracted attention because of its cognitive enhancing properties, including in people with post-traumatic stress disorder (PTSD). Here, we examined the effect of DCS on reversal learning - a type of cognitive flexibility - following exposure to single prolonged stress (SPS), a rodent model of PTSD. Male Sprague Dawley rats (n = 64) were trained to press levers in an operant chamber, matched for performance and assigned to SPS or control (unstressed) groups. Following SPS, rats received three additional lever press sessions, followed by a side bias test on day three. One day later they learned a response discrimination rule (press left or right lever, opposite to side bias) and on a subsequent day were trained (and tested) for reversal to the opposite lever. DCS (15 mg/kg) or vehicle was administered 30 minutes prior to the reversal session. No between-group differences were found in acquisition or retrieval of the initial rule, but a significant drug x stress interaction on response discrimination reversal indicated that DCS had a greater beneficial effect on SPS rats' cognitive flexibility than it did on performance in controls. These findings add to a growing literature on the beneficial effects of DCS for treating a wide variety of deficits that develop following exposure to extreme stress and may have implications for the development of novel pharmacotherapies for PTSD. Copyright © 2018 Elsevier B.V. All rights reserved.

Appetitive operant conditioning in mice: heritability and dissociability of training stages

Directory of Open Access Journals (Sweden)

Hemi A I Malkki

2010-11-01

Full Text Available To study the heritability of different training stages of appetitive operant conditioning, we carried out behavioural screening of 5 standard inbred mouse strains, 28 recombinant-inbred (BxD mouse lines and their progenitor strains C57BL/6J and DBA/2J. We also computed correlations between successive training stages to study whether learning deficits at an advanced stage of operant conditioning may be dissociated from normal performance in preceding phases of training.The training consisted of two phases: an operant nose poking phase, in which mice learned to collect a sucrose pellet from a food magazine by nose poking, and an operant lever press and nose poking phase, in which mice had to execute a sequence of these two actions to collect a food pellet. As a measure of magazine oriented exploration, we also studied the nose poke entries in the food magazine during the intertrial intervals at the beginning of the first session of the nose-poke training phase.We found significantly heritable components in initial magazine checking behaviour, operant nose-poking and lever press-nose poking. Performance levels in these phases were positively correlated, but several individual strains were identified that showed poor lever press-nose poking while performing well in preceding training stages. Quantitative trait loci mapping revealed suggestive likelihood ratio statistic peaks for initial magazine checking behaviour and lever press – nose poking. These findings indicate that consecutive stages towards more complex operant behavior show significant heritable components, as well as dissociability between stages in specific mouse strains. These heritable components may reside in different chromosomal areas.

DIGITAL FLOOD INSURANCE RATE MAP DATABASE, HARRISON COUNTY, MISSISSIPPI AND INCORPORATED AREAS

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk information and supporting data used to develop the risk data. The primary risk...

Environmental enrichment facilitates cocaine abstinence in an animal conflict model.

Science.gov (United States)

Ewing, Scott; Ranaldi, Robert

2018-03-01

In this study, we sought to discover if housing in an enriched environment (EE) is an efficacious intervention for encouraging abstinence from cocaine seeking in an animal "conflict" model of abstinence. Sixteen Long-Evans rats were trained in 3-h daily sessions to self-administer a cocaine solution (1 mg/kg/infusion) until each demonstrated a stable pattern of drug-seeking. Afterward, half were placed in EE cages equipped with toys, obstacles, and a running wheel, while the other half were given clean, standard laboratory housing. All rats then completed daily 30-min sessions during which the 2/3 of flooring closest to the self-administration levers was electrified, causing discomfort should they approach the levers; current strength (mA) was increased after every day of drug seeking until the rat ceased activity on the active lever for 3 consecutive sessions (abstinence). Rats housed in EE abstained after fewer days and at lower current strengths than rats in standard housing. These results support the idea that EE administered after the development of a cocaine-taking habit may be an effective strategy to facilitate abstinence. Copyright © 2018 Elsevier Inc. All rights reserved.

Does engineering education need to engage more with the economic and social aspects of sustainability?

Science.gov (United States)

Fitzpatrick, John J.

2017-11-01

This paper questions if engineering educators are producing engineers that are accelerating humanity along an unsustainable path. Even though technology and engineering are important drivers in trying to move humanity towards an environmentally sustainable paradigm, the paper suggests that maybe the most important levers and challenges lie in the economic and social domains. Short case studies of energy efficiency, the experience of the industrialist Ray Anderson and the authors own reflection of teaching chemical engineering students are used to highlight this. Engineering/technological innovation may not be enough and is often counteracted by the rebound effect and the current dominant neoclassical economic paradigm. The paper discusses what engineering educators can do to produce sustainability informed engineers who are better able to engage with the economic and social dimensions of sustainability. Some suggestions for engaging engineering students with the economic and social dimensions of environmental sustainability are provided. Engineers must somehow find ways, not just to influence technological levers (which are very important) but also to influence economic and social levers so that changes in economic and social behaviours can complement and facilitate technological change in moving humanity to an environmentally sustainable paradigm.

Research on the evacuation readiness of bus crews and passengers. Effect of an easy-to-understand emergency exit display; Bus no jikoji no join jokyaku no dasshutsu yoisei ni kansuru kenkyu. Hijoguchi hyoji kaizen koka no chosa

Energy Technology Data Exchange (ETDEWEB)

Shiosaka, Y. [Japan Automobile Research Institute Inc., Tsukuba (Japan)

1996-10-01

Answers collected from interviews show that very few of the bus passengers know how to open emergency exits and that such exits are floored too high, and dangerous, for aged people and children. In this paper, the emergency exit display is picturized in conformity with the ISO6309-provided evacuation signs, and the Chinese characters on the sign are replaced by `hiragana` characters for the youngest of the elementary school children, unable to Chinese characters, to read with ease. The cover is removed from the lever for opening the emergency exit so that the lever may be seen from the outside. Under the system now in use, the passenger reading the how-to-open explanation cannot see the lever, and therefore it takes some time to know how to open. Exit-indicating arrows are provided on the aisle. Now, almost all the subject passengers can evacuate themselves, including senior citizens and schoolchildren. Using this emergency exit indication method generally judged to be easy to use, the time length has been shortened from the beginning of evacuation to the arrival at the emergency exit. 5 refs., 8 figs.

System analysis of force feedback microscopy

International Nuclear Information System (INIS)

Rodrigues, Mario S.; Costa, Luca; Chevrier, Joël; Comin, Fabio

2014-01-01

It was shown recently that the Force Feedback Microscope (FFM) can avoid the jump-to-contact in Atomic force Microscopy even when the cantilevers used are very soft, thus increasing force resolution. In this letter, we explore theoretical aspects of the associated real time control of the tip position. We take into account lever parameters such as the lever characteristics in its environment, spring constant, mass, dissipation coefficient, and the operating conditions such as controller gains and interaction force. We show how the controller parameters are determined so that the FFM functions at its best and estimate the bandwidth of the system under these conditions

System analysis of force feedback microscopy

Energy Technology Data Exchange (ETDEWEB)

Rodrigues, Mario S. [CFMC/Dep. de Física, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa (Portugal); Costa, Luca [European Synchrotron Radiation Facility, 6 rue Jules Horowitz BP 220, 38043 Grenoble Cedex (France); Université Joseph Fourier BP 53, 38041 Grenoble Cedex 9 (France); Chevrier, Joël [European Synchrotron Radiation Facility, 6 rue Jules Horowitz BP 220, 38043 Grenoble Cedex (France); Université Grenoble Alpes, Inst NEEL, F-38042 Grenoble (France); CNRS, Inst NEEL, F-38042 Grenoble (France); Comin, Fabio [European Synchrotron Radiation Facility, 6 rue Jules Horowitz BP 220, 38043 Grenoble Cedex (France)

2014-02-07

It was shown recently that the Force Feedback Microscope (FFM) can avoid the jump-to-contact in Atomic force Microscopy even when the cantilevers used are very soft, thus increasing force resolution. In this letter, we explore theoretical aspects of the associated real time control of the tip position. We take into account lever parameters such as the lever characteristics in its environment, spring constant, mass, dissipation coefficient, and the operating conditions such as controller gains and interaction force. We show how the controller parameters are determined so that the FFM functions at its best and estimate the bandwidth of the system under these conditions.

Braking System for Wind Turbines

Science.gov (United States)

Krysiak, J. E.; Webb, F. E.

1987-01-01

Operating turbine stopped smoothly by fail-safe mechanism. Windturbine braking systems improved by system consisting of two large steel-alloy disks mounted on high-speed shaft of gear box, and brakepad assembly mounted on bracket fastened to top of gear box. Lever arms (with brake pads) actuated by spring-powered, pneumatic cylinders connected to these arms. Springs give specific spring-loading constant and exert predetermined load onto brake pads through lever arms. Pneumatic cylinders actuated positively to compress springs and disengage brake pads from disks. During power failure, brakes automatically lock onto disks, producing highly reliable, fail-safe stops. System doubles as stopping brake and "parking" brake.

Sustainable cities: A research by McKinsey and Siemens on sustainable development in London

Energy Technology Data Exchange (ETDEWEB)

Denig, Stefan

2010-09-15

The research Sustainable Urban Infrastructure conducted by McKinsey and Company and Siemens assesses technological levers of varying effectiveness, and with different cost implications, which can all contribute to greater environmental sustainability in cities, drawing in particular on the example of London. It's the first comprehensive research focusing on technological and economic implications of a city's infrastructure management in the fields of energy, buildings and transportation. The encouraging message is that many of the levers to reduce energy consumption and CO2 emissions in urban agglomerations not only help protect the environment, but also pay back from an economic point of view.

TEPCV study: lever effect of missed appointment? January 2017

International Nuclear Information System (INIS)

Louis, Charles Adrien

2017-01-01

As the TEPCV (Territory with Positive Energy for a Green Growth) call for project has been able to mobilise French territories, this document presents results of a quantitative analysis of more than 1.700 actions which have been financed since 2015 within the frame of this programme. Thus, the authors aimed at characterising territories which have been subsidised by this call for project, and proposed actions, in order to highlight existing discrepancies, or to identify actual impacts of the call for project while taking stated objectives into account, and to propose ways of improvement for a maximum impact on territories and for citizens. The authors first present the TEPCV call for project: objectives, typology of eligible territories, scope, reciprocal commitments. General results on 1.737 actions are then presented: analysis methodology, distribution of actions with respect to priority axes, distribution of financing among priority axes, average financing, action duration, geographical distribution of actions and subsidies. The third part proposes a typology of financed actions for different domains: reduction of energy consumption, reduction of greenhouse gas emissions and of transport-related pollutions, development of a circular economy and a sustainable waste management, production of local renewable energies, protection of biodiversity and landscapes and promotion of a sustainable town planning, and development of education on the environment. Distribution among French regions is also analysed with respect to the same issues. Successful aspects and areas of improvements are discussed

School Climate and Leadership: Levers for School Improvement Efforts

Science.gov (United States)

Costa, Lois

2016-01-01

This qualitative study considers which aspects of school climate support or inhibit student achievement as each aspect relates to school leadership and school reform efforts. Due to the increased responsibility and accountability which schools face during these challenging times, school climate and the role of the school principal formed the basis…

Leadership development: A lever for system-wide educational change

African Journals Online (AJOL)

Suraiya Naicker

Department of Education Leadership and Management, Faculty of Education ... current significance and pose a challenge for educational leaders. ... Evidence suggests a positive link between high-quality leadership and ... aimed to build leadership capacity that would drive education change directed at improving teaching ...

ACTION LEVERS FOR A SUSTAINABLE FARMLAND MANAGEMENT IN NIGER

Directory of Open Access Journals (Sweden)

Mahamadou Roufahi Tankari

2015-10-01

Full Text Available This study aims to contribute to the understanding of factors influencing the sustainable farmland management in Niger. Specifically, it examines the determinants of adoption of sustainable land management practices including measures to combat erosion, and the use of manure, residues and fertilizer with a view to support the formulation of efficient land use policies based on evidences given fact that the impact of factors influencing farmland management appears to be specific to each context. The study is based on data from the National Survey of Household Living Conditions and Agriculture of 2011 (ECVMA-2011 analyzed within the framework of multivariate Probit model. The results show that there are unobservable interdependences between the decisions on farmland management practices. Furthermore, several types of factors related to access to physical, human, financial and biophysical capitals as well as infrastructure and services seem to play an important role. In addition, it appears that more security is needed in land tenure for a sustainable farmland management while farmland defragmentation can act negatively on sustainable farmland management.

Mathematical model of kinetostatithic calculation of flat lever mechanisms

Directory of Open Access Journals (Sweden)

A. S. Sidorenko

2016-01-01

Full Text Available Currently widely used graphical-analytical methods of analysis largely obsolete, replaced by various analytical methods using computer technology. Therefore, of particular interest is the development of a mathematical model kinetostatical calculation mechanisms in the form of library procedures of calculation for all powered two groups Assyrians (GA and primary level. Before resorting to the appropriate procedure that computes all the forces in the kinematic pairs, you need to compute inertial forces, moments of forces of inertia and all external forces and moments acting on this GA. To this end shows the design diagram of the power analysis for each species GA of the second class, as well as the initial link. Finding reactions in the internal and external kinematic pairs based on equilibrium conditions with the account of forces of inertia and moments of inertia forces (Dalembert principle. Thus obtained equations of kinetostatical for their versatility have been solved by the Cramer rule. Thus, for each GA of the second class were found all 6 unknowns: the forces in the kinematic pairs, the directions of these forces as well as forces the shoulders. If we study kinetostatic mechanism with parallel consolidation of two GA in the initial link, in this case, power is the geometric sum of the forces acting on the primary link from the discarded GA. Thus, the obtained mathematical model kinetostatical calculation mechanisms in the form of libraries of mathematical procedures for determining reactions of all GA of the second class. The mathematical model kinetostatical calculation makes it relatively simple to implement its software implementation.

Afghanistan: Håbet lever – og elektrikerne er tilkaldt

DEFF Research Database (Denmark)

Vestenskov, David

2013-01-01

Håbet for den civile afghaner kan til tider virke som et skamskudt fyrtårn, og det bliver næppe genopbygget af kritiske observationer og selvretfærdig debat. Operationens fokus forud for de udenlandske troppers exit er at udvikle sikkerhedsinstitutionerne og skabe arbejdspladser...

How to make energy transition a lever for competitiveness

International Nuclear Information System (INIS)

Bellamy, Gilles; Ben Brahim, Hedi; Berger, Raphael; Dassa, Francois; Dreyer, Iana; Leger, Sebastien; Maneville, Frederic de; Perez, Yannick; Rosier, Philippe; Rusquec, Jean du; Servan, Thibault; Tlili, Cecile; Tran Thiet, Jean-Paul

2012-11-01

This note examines the major challenges faced by the energy sector in France in a context of continuous cost increase, of lack of domestic production, of high public expenses for the development of renewable energies, of low energy performance, of financial and regulatory framework which does not favour investments. It also highlights the central role of Europe to face these challenges although the European energy policy still lacks ambition, and is still dominated by the climate issue. It formulates a set of propositions about three main axes: a better management of energy consumption, a promotion of new emerging competitive industrial sectors without weakening the sectors of excellence France possesses in the field of energy, and to make the Europe of energy progress

To make a competitiveness lever out of energy transition

International Nuclear Information System (INIS)

Bellamy, Gilles; Ben Brahim, Hedi; Berger, Raphael; Servan, Thibault; Dassa, Francois; Dreyer, Iana; Leger, Sebastien; Maneville, Frederic de; Perez, Yannick; Rosier, Philippe; Rusquec, Jean du; Tlili, Cecile; Tran Thiet, Jean-Paul

2012-11-01

This note focuses of the major challenges for the French energy sector within a context of continuous cost increase, and outlines the central role of Europe to face the energy challenges. The authors state proposals under three main themes: a better management of energy consumption, a support to the emergence of new competitive industrial sectors without weakening the existing ones, and make the Europe of energy progress. The authors address the challenge of energy cost increase (a traditionally efficient French energy mix but with costs to increase in the future, a weak energy performance, a financial and regulatory framework not favourable to investments and innovation), discuss the European energy policy which, according to them, lacks ambition (a policy unbalanced by the prevalence of the climate issue, a national independence in contradiction with increasing interdependencies) and then make their proposals

Leadership Development: A Lever for System-Wide Educational Change

Science.gov (United States)

Naicker, Suraiya R.; Mestry, Raj

2016-01-01

The continuous poor performance of South Africa's learners is detrimental to its developing economy. The need for education change prompted two universities to initiate a system-wide change strategy in a poorly performing school district. The leverage for change was leadership development, involving school principals and district officials. The…

The AP Lever for Boosting Access, Success, and Equity

Science.gov (United States)

Roegman, Rachel; Hatch, Thomas

2016-01-01

Four New Jersey school districts worked together to increase student achievement by applying a number of strategies focused on getting traditionally underrepresented students to take more AP courses. The districts are members of the New Jersey Network of Superintendents (NJNS), comprising 15 superintendents who work together to develop systemwide…

Malaise na een Afrika-reis: amoebenabces van de lever

NARCIS (Netherlands)

Buikhuisen, W. A.; Wetsteyn, J. C. F. M.; van Gool, T.; Kager, P. A.

2002-01-01

During a flight to Kenya, a 42-year-old man took a therapeutic dose of chloroquine because of fever. He regularly travelled to Africa and always took chloroquine and proguanil for malaria prophylaxis. The fever disappeared but he did not fully recover. He complained of malaise and weight loss.

The bioscience revolution & the biological weapons threat: levers & interventions

Directory of Open Access Journals (Sweden)

Martin Greg

2009-02-01

Full Text Available Abstract In December 2008, the US Commission on the Prevention of Weapons of Mass Destruction Proliferation and Terrorism, released a report, World At Risk. The Report points to the fact that, not only is the use of a weapon of mass destruction in a terrorist attack before the end of 2013, more likely than not, but also to the fact that terrorists are more likely to be able to obtain and use biological weapons than nuclear. This paper examines the recommendations of the report in the context of the historic and geopolitical changes, in particular globalization. The authors highlight the "dual-use" dilemma, as described in the report, as the paradoxical use of technology developed for the benefit of mankind being used for sinister purposes. The mitigation of such a threat lies in broad stakeholder involvement and cooperation, including non-state actors, governments and the bio-tech industry itself. The importance of vigilance measures within the life science community is emphasized and, the authors propose, could include a web-based didactic course in bioterrorism and weapons of mass destruction identification. The site could outline safety protocols, have detailed disaster management tutorials, and could be specifically tailored for different subsets of industry and health professionals. The paper concludes with an endorsement of a multi-pronged approach including strong international guidelines and intelligence cooperation and preparatory measures such as the wide-spread use of detection systems as well as diagnostic decision support systems for bioterrorism detection at the local level.

Petroleum: the new challenges. Market pressure and technological lever

International Nuclear Information System (INIS)

Boy de la Tour, X.

1992-01-01

This paper describes the forecasting of petroleum demand during the next years, the state of petroleum reserves and recognized oil fields in the whole world at the present time. The challenge to obtain a sufficient petroleum production, facing an increased energy demand, requires to have recourse to new exploration and oil recovery techniques. 8 refs., 5 figs., 1 tab

A Revision of the Adult and Larval Mosquitoes of Japan (Including the Ryukyu Archipelago and the Ogasawara Islands) and Korea (Diptera: Culicidae)

Science.gov (United States)

1979-01-01

Amami Gun& (I-0284, I-0285, I-1870, I-1893). DISTRIBUTION. RYUKYU ARCHIPELAGO (Amami Gunto). TAIWAN. PHILIPPINES. BORNEO. JAVA . SOUTH CHINA. HONG...Biological data were given by Sakakibara (1960); the larvae were found throughout the year, and hibernate in the first and 2nd instar. It is not known...This species hibernates in the adult stage, and also in the larval stage in the Ryukyus. Harrison and Scanlon (1975) found larvae in Thailand from a

Water Operations Technical Support Program. Water Quality Management for Reservoirs and Tailwaters. Report 1. In-Reservoir Water Quality Management Techniques

Science.gov (United States)

1989-01-01

Harrison was Chief, EL. Drs. J. Barko, J. Mahloch, H. Westerdahl , K. Getsinger, R. Engler, T. Wright, and H. Smith, EL; Messrs. E. Theriot and L. Decell...Brown (1978); Janik, Taylor, and Barko (1980); Hanson and Stefan (1984); Westerdahl and Getsinger (1988). Theory and Design Herbicides and algicides...the plant is unclear except that it behaves like an auxin (Loos 1975, Westerdahl and Hall 1983). The herbicide 2,4-D is particularly effective against

Final Environmental Impact Statement for the Kauai Acoustic Thermometry of Ocean Climate Project and Its Associated Marine Mammal Research Program: Vol 1

Science.gov (United States)

1995-05-01

possibly subadults, were traveling in pairs, and almost half of the recorded sounds were stereotyped doublets, unlike the sounds recorded by Cummings and...purpose and unique stereotyped click sequence "codas" have been recorded from individual whales over periods lasting several hours (Watldns and Schevill...Beaked whales of the genus Mesoplodon. pp 349-430. In: S.H. Ridgway and R. Harrison (eds.), Handbook of marine mammals, Vol. 4. Academic Press Ltd. Meller

Onderzoek naar leverbot deel 1: Instrument voor bedrijfsanalyse op risicofacturen leverbotbestrijding

NARCIS (Netherlands)

Verwer, Cynthia; Verkaik, Jan; Neijenhuis, Francesca

2017-01-01

risico’s & kansen Een in Nederland afgekeurde lever met vergrote galgangen met aanwijzingen voor ontsteking. Leverbotbestrijding Instrument voor bedrijfsanalyse op risicofactoren risico’s & kansen

Learning not to respond: Role of the hippocampus in withholding responses during omission training.

Science.gov (United States)

White, Norman M; Naeem, Maliha

2017-02-01

Autoshaping is a Pavlovian learning paradigm in which rats experience pairings of a CS and a US independently of their behavior. When the CS is a lever inserted into the test cage and the US is food delivered to an adjacent magazine, many rats acquire a lever-pressing response called 'sign-tracking' even though that response has no effect on the occurrence of either the CS or the US. Since these lever presses are always followed by the US, it has been suggested that sign-tracking could be due to unintended reinforcement of the response. To eliminate the possibility of such instrumental learning the omission schedule, in which a response to the CS cancels the US, was introduced. Previous research has shown that training rats on autoshaping and switching them to an omission schedule generally reduces but does not eliminate sign-tracking, suggesting that it may be due to both Pavlovian and instrumental learning. In the present study naive rats trained on an omission schedule sign-tracked less than a control group exposed to random, unpaired CS and US presentations, suggesting that they learned to withhold the lever press response because of the negative contingency between that response and the US. In a second experiment rats with dorsal hippocampus lesions sign-tracked more than sham-lesioned rats on omission schedules, suggesting that this case of learning not to respond is hippocampus-based. This conclusion is consistent with many previous findings on the inability of hippocampal rats to withhold or suppress responding, and with studies suggesting that one form of extinction of learned responses in normal rats is due to competition from hippocampus-based learning not to respond. Copyright © 2016 Elsevier B.V. All rights reserved.

Modelling Per Capita Water Demand Change to Support System Planning

Science.gov (United States)

Garcia, M. E.; Islam, S.

2016-12-01

Water utilities have a number of levers to influence customer water usage. These include levers to proactively slow demand growth over time such as building and landscape codes as well as levers to decrease demands quickly in response to water stress including price increases, education campaigns, water restrictions, and incentive programs. Even actions aimed at short term reductions can result in long term water usage declines when substantial changes are made in water efficiency, as in incentives for fixture replacement or turf removal, or usage patterns such as permanent lawn watering restrictions. Demand change is therefore linked to hydrological conditions and to the effects of past management decisions - both typically included in water supply planning models. Yet, demand is typically incorporated exogenously using scenarios or endogenously using only price, though utilities also use rules and incentives issued in response to water stress and codes specifying standards for new construction to influence water usage. Explicitly including these policy levers in planning models enables concurrent testing of infrastructure and policy strategies and illuminates interactions between the two. The City of Las Vegas is used as a case study to develop and demonstrate this modeling approach. First, a statistical analysis of system data was employed to rule out alternate hypotheses of per capita demand decrease such as changes in population density and economic structure. Next, four demand sub-models were developed including one baseline model in which demand is a function of only price. The sub-models were then calibrated and tested using monthly data from 1997 to 2012. Finally, the best performing sub-model was integrated with a full supply and demand model. The results highlight the importance of both modeling water demand dynamics endogenously and taking a broader view of the variables influencing demand change.

The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: a novel possible model of OCD.

Science.gov (United States)

Eagle, Dawn M; Noschang, Cristie; d'Angelo, Laure-Sophie Camilla; Noble, Christie A; Day, Jacob O; Dongelmans, Marie Louise; Theobald, David E; Mar, Adam C; Urcelay, Gonzalo P; Morein-Zamir, Sharon; Robbins, Trevor W

2014-05-01

Excessive checking is a common, debilitating symptom of obsessive-compulsive disorder (OCD). In an established rodent model of OCD checking behaviour, quinpirole (dopamine D2/3-receptor agonist) increased checking in open-field tests, indicating dopaminergic modulation of checking-like behaviours. We designed a novel operant paradigm for rats (observing response task (ORT)) to further examine cognitive processes underpinning checking behaviour and clarify how and why checking develops. We investigated i) how quinpirole increases checking, ii) dependence of these effects on D2/3 receptor function (following treatment with D2/3 receptor antagonist sulpiride) and iii) effects of reward uncertainty. In the ORT, rats pressed an 'observing' lever for information about the location of an 'active' lever that provided food reinforcement. High- and low-checkers (defined from baseline observing) received quinpirole (0.5mg/kg, 10 treatments) or vehicle. Parametric task manipulations assessed observing/checking under increasing task demands relating to reinforcement uncertainty (variable response requirement and active-lever location switching). Treatment with sulpiride further probed the pharmacological basis of long-term behavioural changes. Quinpirole selectively increased checking, both functional observing lever presses (OLPs) and non-functional extra OLPs (EOLPs). The increase in OLPs and EOLPs was long-lasting, without further quinpirole administration. Quinpirole did not affect the immediate ability to use information from checking. Vehicle and quinpirole-treated rats (VEH and QNP respectively) were selectively sensitive to different forms of uncertainty. Sulpiride reduced non-functional EOLPs in QNP rats but had no effect on functional OLPs. These data have implications for treatment of compulsive checking in OCD, particularly for serotonin-reuptake-inhibitor treatment-refractory cases, where supplementation with dopamine receptor antagonists may be beneficial

The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: A novel possible model of OCD?

Science.gov (United States)

Eagle, Dawn M.; Noschang, Cristie; d’Angelo, Laure-Sophie Camilla; Noble, Christie A.; Day, Jacob O.; Dongelmans, Marie Louise; Theobald, David E.; Mar, Adam C.; Urcelay, Gonzalo P.; Morein-Zamir, Sharon; Robbins, Trevor W.

2014-01-01

Excessive checking is a common, debilitating symptom of obsessive-compulsive disorder (OCD). In an established rodent model of OCD checking behaviour, quinpirole (dopamine D2/3-receptor agonist) increased checking in open-field tests, indicating dopaminergic modulation of checking-like behaviours. We designed a novel operant paradigm for rats (observing response task (ORT)) to further examine cognitive processes underpinning checking behaviour and clarify how and why checking develops. We investigated i) how quinpirole increases checking, ii) dependence of these effects on D2/3 receptor function (following treatment with D2/3 receptor antagonist sulpiride) and iii) effects of reward uncertainty. In the ORT, rats pressed an ‘observing’ lever for information about the location of an ‘active’ lever that provided food reinforcement. High- and low-checkers (defined from baseline observing) received quinpirole (0.5 mg/kg, 10 treatments) or vehicle. Parametric task manipulations assessed observing/checking under increasing task demands relating to reinforcement uncertainty (variable response requirement and active-lever location switching). Treatment with sulpiride further probed the pharmacological basis of long-term behavioural changes. Quinpirole selectively increased checking, both functional observing lever presses (OLPs) and non-functional extra OLPs (EOLPs). The increase in OLPs and EOLPs was long-lasting, without further quinpirole administration. Quinpirole did not affect the immediate ability to use information from checking. Vehicle and quinpirole-treated rats (VEH and QNP respectively) were selectively sensitive to different forms of uncertainty. Sulpiride reduced non-functional EOLPs in QNP rats but had no effect on functional OLPs. These data have implications for treatment of compulsive checking in OCD, particularly for serotonin-reuptake-inhibitor treatment-refractory cases, where supplementation with dopamine receptor antagonists may be

Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A2A and A1 antagonists

Science.gov (United States)

Randall, Patrick A.; Nunes, Eric J.; Janniere, Simone L.; Stopper, Colin M.; Farrar, Andrew M.; Sager, Thomas N.; Baqi, Younis; Hockemeyer, Jörg; Müller, Christa E.

2012-01-01

Rationale Adenosine A2A antagonists can reverse many of the behavioral effects of dopamine antagonists, including actions on instrumental behavior. However, little is known about the effects of selective adenosine antagonists on operant behavior when these drugs are administered alone. Objective The present studies were undertaken to investigate the potential for rate-dependent stimulant effects of both selective and nonselective adenosine antagonists. Methods Six drugs were tested: two nonselective adenosine antagonists (caffeine and theophylline), two adenosine A1 antagonists (DPCPX and CPT), and two adenosine A2A antagonists (istradefylline (KW6002) and MSX-3). Two schedules of reinforcement were employed; a fixed interval 240-s (FI-240 sec) schedule was used to generate low baseline rates of responding and a fixed ratio 20 (FR20) schedule generated high rates. Results Caffeine and theophylline produced rate-dependent effects on lever pressing, increasing responding on the FI-240 sec schedule but decreasing responding on the FR20 schedule. The A2A antagonists MSX-3 and istradefylline increased FI-240 sec lever pressing but did not suppress FR20 lever pressing in the dose range tested. In fact, there was a tendency for istradefylline to increase FR20 responding at a moderate dose. A1 antagonists failed to increase lever pressing rate, but DPCPX decreased FR20 responding at higher doses. Conclusions These results suggest that adenosine A2A antagonists enhance operant response rates, but A1 antagonists do not. The involvement of adenosine A2A receptors in regulating aspects of instrumental response output and behavioral activation may have implications for the treatment of effort-related psychiatric dysfunctions, such as psychomotor slowing and anergia in depression. PMID:21347642

Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABAB and cannabinoid CB1 receptors.

Science.gov (United States)

Maccioni, Paola; Colombo, Giancarlo; Lorrai, Irene; Zaru, Alessandro; Carai, Mauro A M; Gessa, Gian Luigi; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico

2017-09-01

COR659 [methyl2-(4-chlorophenylcarboxamido)-4-ethyl-5-methylthiophene-3-carboxylate] is a new, positive allosteric modulator (PAM) of the GABA B receptor. This study evaluated whether COR659 shared with previously tested GABA B PAMs the capacity to reduce alcohol self-administration in rats. Treatment with non-sedative doses of COR659 (2.5, 5, and 10 mg/kg; i.p.) suppressed lever-responding for alcohol (15% v/v) in Sardinian alcohol-preferring (sP) rats under the fixed ratio (FR) 4 (FR4) and progressive ratio (PR) schedules of reinforcement; COR659 was more potent and effective than the reference GABA B PAM, GS39783. Treatment with COR659, but not GS39783, suppressed (a) lever-responding for a sucrose solution (1-3% w/v) in sP rats under the FR4 and PR schedules, (b) lever-responding for a chocolate solution [5% (w/v) Nesquik®] in Wistar rats under the FR10 and PR schedules, and (c) cue-induced reinstatement of chocolate seeking in Wistar rats. Treatment with COR659 was completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats. Pretreatment with the GABA B receptor antagonist, SCH50911, partially blocked COR659-induced reduction of alcohol self-administration, being ineffective on reduction of chocolate self-administration. Pretreatment with the cannabinoid CB 1 receptor antagonist, AM4113, fully blocked COR659-induced reduction of chocolate self-administration, being ineffective on reduction of alcohol self-administration. COR659 might exert its behavioral effects via a composite mechanism: (i) positive allosteric modulation of the GABA B receptor, responsible for a large proportion of reduction of alcohol self-administration; (ii) an action at other receptor system(s), including the cannabinoid CB 1 receptor, through which COR659 affects seeking and consumption of highly palatable foods.

Method and jig for dismantling nuclear fuel assembly

International Nuclear Information System (INIS)

Urata, Megumi; Watahiki, Minoru.

1989-01-01

The object of the present inention is to extract a fuel element from a lower tie plate safely and at high efficiency by a remote control operation. That is, a forked top end of a lever of a dismantling jig is inserted between the tapered portion of a lower end plug and a lower tie plate. Then, a load is applied to the counter-lower end side of the lever by a motor. This exerts an elevating force to the fuel elements to easily release fixture between the lower end plug and the lower tie plate. Since the fuel can of fuel elements is not applied with a force by this mehtod, operation safety can be improved. (I.J.)

Implementing energy transition - A legal deciphering

International Nuclear Information System (INIS)

Bain-Thouverez, Justine; Romi, Raphael; Chautard, Thomas

2016-07-01

As the French law on energy transition reconfigures many parameters of implementation of public action, the authors propose a cross-referenced reading of this law, of the law for new organisation of territories (NOTRe) in its environmental dimension, and of the regulation which results from these legal standards, in order to have a better view on public action in terms of abilities, and of action and financial levers. In a first part, the author discuss the relationships of energy transition with State, regions, districts, EPCI (communal collaboration public body), communes, and public bodies. In the second part, they address the new levers for action, and finally address the financing of energy transition (financing funds, third-party financing companies)

Hand sanitizer dispensers and associated hospital-acquired infections: friend or fomite?

Science.gov (United States)

Eiref, Simon D; Leitman, I Michael; Riley, William

2012-06-01

Waterless alcohol-based hand sanitizers are an increasingly popular method of hand hygiene and help prevent hospital-acquired infection (HAI). Whether hand sanitizer dispensers (HSDs) may themselves harbor pathogens or act as fomites has not been reported. All HSDs in the surgical intensive care unit of an urban teaching hospital were cultured at three sites: The dispenser lever, the rear underside, and the area surrounding the dispensing nozzle. All HSDs yielded one or more bacterial species, including commensal skin flora and enteric gram-negative bacilli. Colonization was greatest on the lever, where there is direct hand contact. Hand sanitizer dispensers can become contaminated with pathogens that cause HAI and thus are potential fomites.

Assessing opportunities and constraints for biofuel development in sub-Saharan Africa

CSIR Research Space (South Africa)

Von Maltitz, Graham P

2011-01-01

Full Text Available , the development of sustainability principles, criteria and indicators for biofuel development, and constraints to imports in the EU, have been some key responses to reduce unsustainable practices (Harrison et al. 2010a, Vis et al. 2008). �ough the adoption... FSC Forest Stewardship Council GAIA Movement Trust Living Earth Green World Action GAP Good Agricultural Practices GHG Greenhouse gas GIZ Gesellscha� f?r Internationale Zusammenarbeit Ha Hectare HCV High Conservation Value HDI Human Development...

The Effects of Tank Crew Turbulence on Tank Gunnery Performance

Science.gov (United States)

1978-09-01

complete. Crewmen’s responses were converted to mouths for all itqms and tabulated for analysis. Because data was tabulated to two digits a maximum...two- digit data tabulation, mean and standard deviation statistics are somewhat conserva- tive for items 8, 9, and 10. There were 14-1S% of the TCs who...Benjamin Harrison. ATTN Libary I HQOA (DAMA-ARI I USAPACDC. Ft SBenjamuun Haritson, ATTN; ATCP-IHR I HOCIA OAPE HRE PO) IUSA Comrm- Elect Sch

Browse Author Index

African Journals Online (AJOL)

Items 1 - 50 of 52 ... A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All. H. Habib, Abdulrazaq Garba · Haffejee, Sadiyya · Hailu, Dejene · Hallfors, Denise Dion · Hallin, Mary · Hallman, Kelly · Hanass-Hancock, Jill · Hardy, Chloe · Harinarain, Nishani · Harms, Sheila · Harper, Gary W · Harris, Chantal · Harrison, Kathleen ...

Isolation of Retroelement from Plant Genomic DNA

OpenAIRE

sprotocols

2014-01-01

Author: Pat Heslop-Harrison ### Abstract: Retroelements and their derivatives are an ubiquitous and abundant component of plant genomes. From the 1990s, PCR based techniques have been developed to isolate the elements from genomic DNA of different plants, and the methods and primers used are presented here. Major classes of retroelements include the Ty1-copia, the Ty3-gypsy and the LINE (non-LTR) groups. Mixed PCR products representing the full heterogeneous pool of retrotransposo...

The Polish LGBT movement : symbolic conflict and stigma

OpenAIRE

Mossakowski, Tomek

2011-01-01

This thesis examines the political activities of the LGBT movement in Poland as it seeks to increase its position on the socio-political landscape and ultimately rid itself of stigma. Using ethnographic data collection at a non-governmental organisation in Warsaw, it discusses the use of symbols and the accumulation of what Bourdieu called symbolic capital. It draws heavily on the theory of Harrison's symbolic conflict and Schwimmer's notions of symbolic and direct competition, while bringing...

Electrically charged dilatonic black rings

International Nuclear Information System (INIS)

Kunduri, Hari K.; Lucietti, James

2005-01-01

In this Letter we present (electrically) charged dilatonic black ring solutions of the Einstein-Maxwell-dilaton theory in five dimensions and we consider their physical properties. These solutions are static and as in the neutral case possess a conical singularity. We show how one may remove the conical singularity by application of a Harrison transformation, which physically corresponds to supporting the charged ring with an electric field. Finally, we discuss the slowly rotating case for arbitrary dilaton coupling

Differential Dengue Tropism & Neutralization: Potential Mechanisms of Pathogenesis

Science.gov (United States)

2006-01-04

Venezuela, 1990- 1997]. Acta Cient Venez 49 Suppl 1, 33-7. Smith, G.W. and Wright, P.J. (1985) Synthesis of proteins and glycoproteins in dengue type 2...R. Tilley, G. Lloyd, C. Finlayson, H. Tolley, P. Newman, P. Rice, and T. S. Harrison. 2003. Dengue hemorrhagic fever with fulminant hepatic...George, and S. Devi. 1993. Fulminant hepatitis in dengue infection. Southeast Asian J Trop Med Public Health 24:467-71. 180. Mady, B. J., D. V. Erbe, I

Corticospinal signals recorded with MEAs can predict the volitional forearm forces in rats.

Science.gov (United States)

Guo, Yi; Mesut, Sahin; Foulds, Richard A; Adamovich, Sergei V

2013-01-01

We set out to investigate if volitional components in the descending tracts of the spinal cord white matter can be accessed with multi-electrode array (MEA) recording technique. Rats were trained to press a lever connected to a haptic device with force feedback to receive sugar pellets. A flexible-substrate multi-electrode array was chronically implanted into the dorsal column of the cervical spinal cord. Field potentials and multi-unit activities were recorded from the descending axons of the corticospinal tract while the rat performed a lever pressing task. Forelimb forces, recorded with the sensor attached to the lever, were reconstructed using the hand position data and the neural signals through multiple trials over three weeks. The regression coefficients found from the trial set were cross-validated on the other trials recorded on same day. Approximately 30 trials of at least 2 seconds were required for accurate model estimation. The maximum correlation coefficient between the actual and predicted force was 0.7 in the test set. Positional information and its interaction with neural signals improved the correlation coefficient by 0.1 to 0.15. These results suggest that the volitional information contained in the corticospinal tract can be extracted with multi-channel neural recordings made with parenchymal electrodes.

Pavlovian conditioning with ethanol: sign-tracking (autoshaping), conditioned incentive, and ethanol self-administration.

Science.gov (United States)

Krank, Marvin D

2003-10-01

Conditioned incentive theories of addictive behavior propose that cues signaling a drug's reinforcing effects activate a central motivational state. Incentive motivation enhances drug-taking and drug-seeking behavior. We investigated the behavioral response to cues associated with ethanol and their interaction with operant self-administration of ethanol. In two experiments, rats received operant training to press a lever for a sweetened ethanol solution. After operant training, the animals were given Pavlovian pairings of a brief and localized cue light with the sweetened ethanol solution (no lever present). Lever pressing for ethanol was then re-established, and the behavioral effects of the cue light were tested during an ethanol self-administration session. The conditioned responses resulting from pairing cue lights with the opportunity to ingest ethanol had three main effects: (1) induction of operant behavior reinforced by ethanol, (2) stimulation of ethanol-seeking behavior (magazine entries), and (3) signal-directed behavior (i.e., autoshaping, or sign-tracking). Signal-directed behavior interacted with the other two effects in a manner predicted by the location of the cue light. These conditioned responses interact with operant responding for ethanol reinforcement. These findings demonstrate the importance of Pavlovian conditioning effects on ethanol self-administration and are consistent with conditioned incentive theories of addictive behavior.

Effect of botanical extracts containing carnosic acid or rosmarinic acid on learning and memory in SAMP8 mice.

Science.gov (United States)

Farr, Susan A; Niehoff, Michael L; Ceddia, Michael A; Herrlinger, Kelli A; Lewis, Brandon J; Feng, Shulin; Welleford, Andrew; Butterfield, D Allan; Morley, John E

2016-10-15

Oxidative damage is one of the hallmarks of the aging process. The current study evaluated effects of two proprietary antioxidant-based ingredients, rosemary extract and spearmint extract containing carnosic acid and rosmarinic acid, respectively, on learning and memory in the SAMP8 mouse model of accelerated aging. The two rosemary extracts contained carnosic acid (60% or 10% carnosic acid) and one spearmint extract contained 5% rosmarinic acid. Three doses of actives in each extract were tested: 32, 16, 1.6 or 0mg/kg. After 90days of treatment mice were tested in T-maze foot shock avoidance, object recognition and lever press. Rosemary extract containing 60% carnosic acid improved acquisition and retention in T-maze foot shock, object recognition and lever press. Rosemary extract with 10% carnosic acid improved retention in T-maze foot shock avoidance and lever press. Spearmint with 5% rosmarinic acid improved acquisition and retention in T-maze foot shock avoidance and object recognition. 4-hydroxynonenal (HNE) was reduced in the brain cortex after treatment with all three extracts (Prosemary with 10% carnosic acid (Prosemary have beneficial effects on learning and memory and brain tissue markers of oxidation that occur with age in SAMP8 mice. Published by Elsevier Inc.

Distribution and evolution of stable single α-helices (SAH domains in myosin motor proteins.

Directory of Open Access Journals (Sweden)

Dominic Simm

Full Text Available Stable single-alpha helices (SAHs are versatile structural elements in many prokaryotic and eukaryotic proteins acting as semi-flexible linkers and constant force springs. This way SAH-domains function as part of the lever of many different myosins. Canonical myosin levers consist of one or several IQ-motifs to which light chains such as calmodulin bind. SAH-domains provide flexibility in length and stiffness to the myosin levers, and may be particularly suited for myosins working in crowded cellular environments. Although the function of the SAH-domains in human class-6 and class-10 myosins has well been characterised, the distribution of the SAH-domain in all myosin subfamilies and across the eukaryotic tree of life remained elusive. Here, we analysed the largest available myosin sequence dataset consisting of 7919 manually annotated myosin sequences from 938 species representing all major eukaryotic branches using the SAH-prediction algorithm of Waggawagga, a recently developed tool for the identification of SAH-domains. With this approach we identified SAH-domains in more than one third of the supposed 79 myosin subfamilies. Depending on the myosin class, the presence of SAH-domains can range from a few to almost all class members indicating complex patterns of independent and taxon-specific SAH-domain gain and loss.

Policy for material efficiency--sustainable taxation as a departure from the throwaway society.

Science.gov (United States)

Stahel, Walter R

2013-03-13

The present economy is not sustainable with regard to its per capita material consumption. A dematerialization of the economy of industrialized countries can be achieved by a change in course, from an industrial economy built on throughput to a circular economy built on stock optimization, decoupling wealth and welfare from resource consumption while creating more work. The business models of a circular economy have been known since the mid-1970s and are now applied in a number of industrial sectors. This paper argues that a simple and convincing lever could accelerate the shift to a circular economy, and that this lever is the shift to a tax system based on the principles of sustainability: not taxing renewable resources including human labour--work--but taxing non-renewable resources instead is a powerful lever. Taxing materials and energies will promote low-carbon and low-resource solutions and a move towards a 'circular' regional economy as opposed to the 'linear' global economy requiring fuel-based transport for goods throughput. In addition to substantial improvements in material and energy efficiency, regional job creation and national greenhouse gas emission reductions, such a change will foster all activities based on 'caring', such as maintaining cultural heritage and natural wealth, health services, knowledge and know-how.

Effects of exposure to 56Fe particles of protons on fixed-ratio operant responding in rats

International Nuclear Information System (INIS)

Rabin, B.M.; Buhler, L.L.; Jenkins, D.G.; Joseph, J.A.; Shukitt-Hale, B.

2002-01-01

On long-duration trips outside of the magnetosphere, astronauts will be exposed to protons and to heavy particles which can affect their performance of required tasks. It is essential to determine the range of behaviors that might be affected by exposure to these types of radiation in order to understand the nature of behavioral deficits and to develop effective countermeasures. The present experiment examined the ability of rats to make an operant response following exposure to protons (250 MeV, 4 Gy) or 56 Fe particles (1 GeV/n, 1 or 2 Gy). Following irradiation, rats were trained to press a lever in order to obtain food reinforcement. They were then placed on an ascending fixed-ratio schedule from FR-1 (each lever press rewarded with a food pellet) through FR-35 (35 lever presses required for 1 food pellet). Rats exposed to 4 Gy of protons or 1 Gy of 56 Fe particles responded similarly to controls, increasing their rate of responding as the ratio increased. However, rats exposed to 2 Gy of 56 Fe particles failed to increase their rate of responding at ratios greater than FR-20, indicating that rats exposed to 2 Gy of 56 Fe particles cannot respond appropriately to increasing work requirements. (author)

Bucket drill

Energy Technology Data Exchange (ETDEWEB)

Bezverkhiy, V.M.; Nabokov, I.M.; Podoksik, D.Z.; Sadovskiy, S.S.; Shanyukevich, V.A.

1983-01-01

The bucket drill including a cylindrical housing with bottom, ground intake windows and cutting knives is hinged to the housing, the mechanism of rotation of the cutting knives including rods connected by the cutter knives, and drive shaft is distinguished by the fact that in order to improve the effectiveness of drilling by automatic change in the angle of cutting depending on the strength of the drillable rock, the drill is equipped with elastic elements and cap with annular slits in which there are elastic elements. The mechanism of rotation of the cutting knives is equipped with levers hinged to the housing, pins with shaft and rocker arm. The rods are made with a slit and from one end are rigidly connected to the cutting knives, and from the other end to the levers by means of pins which are arranged in slits of the rod with the possibility of movement. The upper ends of the levers are installed with the possibility of movement in the pins whose shafts are arranged with the possibility of rotation in the rocker arm rigidly connected to the drive shaft. The drive shaft is equipped with cantilevers installed in the cap with the possibility of rotation and interaction with the elastic elements.

Pyrene degradation by yeasts and filamentous fungi.

Science.gov (United States)

Romero, M Cristina; Salvioli, Mónica L; Cazau, M Cecilia; Arambarri, A M

2002-01-01

The saprotrophic soil fungi Fusarium solani (Mart.) Sacc., Cylindrocarpon didymum (Hartig) Wollenw, Penicillium variabile Sopp. and the yeasts Rhodotorula glutinis (Fresenius) Harrison and Rhodotorula minuta (Saito) Harrison were cultured in mineral medium with pyrene. The remaining pyrene concentrations were periodically determined during 20 incubation days, using HPLC. To assess the metabolism of pyrene degradation we added 0.1 microCi of [4,5,9,10] 14C-pyrene to each fungi culture and measured the radioactivity in the volatile organic substances, extractable, aqueous phase, biomass and 14CO2 fractions. The assays demonstrated that F. solani and R. glutinis metabolized pyrene as a sole source of carbon. Differences in their activities at the beginning of the cultures disappeared by the end of the experiment, when 32 and 37% of the original pyrene concentration was detected, for the soil fungi and yeasts, respectively. Among the filamentous fungi, F. solani was highly active and oxidized pyrene; moreover, small but significant degradation rates were observed in C. didymum and P. variahile cultures. An increase in the 14CO2 evolution was observed at the 17th day with cosubstrate. R. glutinis and R. minuta cultures showed similar ability to biotransform pyrene, and that 35% of the initial concentration was consumed at the end of the assay. The same results were obtained in the experiments with or without glucose as cosubstrate.

Round the World in Sixty Minutes: approaches to the evocation of space, place and location in recent multichannel works

Directory of Open Access Journals (Sweden)

Jonty Harrison

2016-10-01

Full Text Available ABSTRACT This article discusses some of the preoccupations of my recent acousmatic music: the evocation of place, the potential for the recognition of sources (even down to their specific locations, in some cases and the associated concern with ‘space’, in terms of both geography and musical thinking. It is prompted by the release of my latest CD, Voyages (HARRISON, 2016. But this album did not emerge from nothing; it is the product of over 40 years of working in the studio (and performing with loudspeakers. It may therefore be useful to offer some historical perspective. RESUMO Este artigo aborda algumas das preocupações da minha música acusmática recente: a evocação de lugar, o potencial para o reconhecimento das fontes (até mesmo em relação aos seus locais específicos, em alguns casos e a preocupação associada com o 'espaço', tanto em termos da geografia quanto do pensamento musical. É motivado pelo lançamento do meu último CD, Voyages (HARRISON, 2016. Mas este álbum não surgiu do nada; é o produto de mais de 40 anos de trabalho no estúdio (e de performances com altofalantes. O artigo pode, portanto, ser útil para oferecer alguma perspectiva histórica.

Social Responsibility as a Management Control System

National Research Council Canada - National Science Library

Barger, Anthony

2004-01-01

...) to balance business strategy. The authors examine how management control systems for social responsibility apply to each control lever both in theory and through the application of case examples...

Single-source mechanical loading system produces biaxial stresses in cylinders

Science.gov (United States)

Flower, J. F.; Stafford, R. L.

1967-01-01

Single-source mechanical loading system proportions axial-to-hoop tension loads applied to cylindrical specimens. The system consists of hydraulic, pneumatic, and lever arrangements which produce biaxial loading ratios.

Advanced maternal age: ethical and medical considerations for assisted reproductive technology

OpenAIRE

Harrison,Brittany; Hilton,Tara; Rivière,Raphaël; Ferraro,Zachary; Deonandan,Raywat; Walker,Mark

2017-01-01

Brittany J Harrison,1 Tara N Hilton,1 Raphaël N Rivière,1 Zachary M Ferraro,1–3 Raywat Deonandan,4 Mark C Walker1–3,51Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; 2Division of Maternal-Fetal Medicine, University of Ottawa, The Ottawa Hospital, Ottawa, ON, Canada; 3Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada; 4University of Ottawa Interdisciplinary School of Health Sciences, Ottawa, ON, Canada; 5...

Restoration scaling of seagrass habitats in the oceanic islands of Lakshadweep, India using geospatial technology

Digital Repository Service at National Institute of Oceanography (India)

Nobi, E.P.; Dilipan, E.; Thangaradjou, T.; DineshKumar, P.K.

) Guidelines for the conservation and restoration of seagrasses in the United States and adjacent waters. Silver Spring (MD): NOAA Coastal Ocean Program Decision Analysis Series no. 12 Harrison PG (1990) Variations in success of eelgrass transplants over a... and field observations Satellite data of the years 2000 (IRS ID LISS III) and 2008 (IRS P6 LISS III) were used for estimating the seagrass spatial changes over a time period for the six islands following the methodology of Mumby and Green (2000). Digital...

Carbon monoxide, industry, and performance. Third joint meeting of the British Occupational Hygiene Society, the Ergonomics Research Society, and the Society of Occupational Medicine

Energy Technology Data Exchange (ETDEWEB)

1975-08-01

This meeting, held at Swansea in September 1974, covered the following aspects: arterial disease among blast furnace workers; threshold limit values (TLVs) under conditions of continuous exposure (closed environment of nuclear submarines); discussion of TLV for CO; methods of CO determination in air (Harrison N.); the infrared gas analysis; electrochemical CO sensors based on the metallised membrane electrode; solid state detectors; measurement of CO in blood (comparative review of methods); warning levels and alarm instrumentation; also: ergonomics of aircrew respiratory apparatus.

77 FR 39226 - Applications for New Awards: Technical Assistance and Dissemination To Improve Services and...

Science.gov (United States)

2012-07-02

... employing EBPs, and assist administrators in thinking through systemic changes to better support the use of...., & Young, L. (2012). Implementation teams: A new lever for organizational change. Journal of Organizational...

Effects of extinction in multiple contexts on renewal of instrumental responses.

Science.gov (United States)

Bernal-Gamboa, Rodolfo; Nieto, Javier; Uengoer, Metin

2017-09-01

In two experiments with rats, we investigated the effects of using multiple contexts during extinction on renewal of lever-pressing behavior. During the first phase of both experiments, rats were reinforced to press a lever for food in Context A. Then, responses underwent extinction. For half of the animals, extinction sessions were conducted in a single context, whereas the other half received extinction in three different contexts. In Experiment 1, we observed that extinction in multiple contexts eliminated ABC renewal, but had no detectable impact on ABA renewal. Experiment 2 revealed that conducting extended extinction training in multiple contexts attenuated ABA renewal. Theoretical and clinical implications of the present findings are discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

Dose and elasticity of demand for self-administered cocaine in rats.

Science.gov (United States)

Kearns, David N; Silberberg, Alan

2016-04-01

The present experiment tested whether the elasticity of demand for self-administered cocaine in rats is dose-dependent. Subjects lever pressed for three different doses of intravenous cocaine - 0.11, 0.33, and 1.0 mg/kg/infusion - on a demand procedure where the number of lever presses required per infusion increased within a session. The main finding was that demand for the 0.11 mg/kg dose was more elastic than it was for the two larger doses. There was no difference in demand elasticity between the 0.33 and 1.0 mg/kg doses. These results parallel findings previously reported in monkeys. The present study also demonstrated that a within-session procedure can be used to generate reliable demand curves.

Iron appetite and latent learning in rats.

Science.gov (United States)

Woods, S C; Vasselli, J R; Milam, K M

1977-11-01

Two experiments are reported which show that rats are capable of forming an association between the presence of iron in a solution when it is not specifically needed and a subsequent state of iron deficiency. Specifically, rats were trained to lever press for water while thirsty. One group received ferrous ions in addition to the water. When these rats were subsequently rendered iron deficient, they lever pressed more under extinction conditions as a graded function of lower hemoglobin levels. Controls that either did not receive ferrous ions during training or received solutions other than ferrous solutions during training did not respond this way under extinction conditions. This is therefore a type of latent learning previously demonstrated only for sodium appetite.

The March 2004 Riots in Kosovo: A Failure of the International Community

National Research Council Canada - National Science Library

Daltveit, Egil

2007-01-01

.... KFOR and UNMIK failed to use the levers of hard power -- the principled and decisive application of force -- or of soft power -- education, the media, and the symbolic environment -- to convince...

Carbon righteousness: how to lever pro-poor benefits from REDD+

Energy Technology Data Exchange (ETDEWEB)

Scwarte, Christoph [Foundation for International Environmental Law and Development(United Kingdom); Mohammed, Essam Yassin

2011-07-15

A growing focus on mitigating climate change by reducing emissions from deforestation and forest degradation (REDD and REDD+) is prompting the creation of a new form of private property — the 'carbon right' — that can be bought and sold in domestic or international markets. But to make REDD+ work for the poor, carbon trading schemes will have to ensure that a wide range of forest-dependent groups and communities benefit. In part, this means carefully assessing how carbon rights are assigned — to ensure they support the rural poor who rarely hold formal land ownership or tenure rights but who are key players in putting sustainable forest management into practice on the ground. It also means rethinking eligibility criteria for REDD+ projects so that they include economic, social and environmental standards and co-benefits.

Sri Lankan English O Level: Lever for Change. Practical Considerations.

Science.gov (United States)

Nanayakkara, Ethel; Webber, Richard

A discussion of the new Sri Lankan General Certificate of Education (GCE) O-Level standardized test of English focuses on how new ideas in testing have been implemented in the test and on their effect on classroom practice and the quality of English instruction. The discussion begins with a brief outline of the history and context in which the new…

1800 mechanical movements, devices and appliances

CERN Document Server

Hiscox, Gardner D

2007-01-01

A fascinating compendium of early-20th-century mechanical devices, this expansive work ranges from basic levers to complex machinery. More than 1,800 engravings include simple illustrations and detailed cross-sections.

Behavioral Neurophysiology of Ethanol

National Research Council Canada - National Science Library

Janak, Patricia

2002-01-01

.... Alcohol consumption by humans can be modeled in the rat using operant behavioral procedures in which an arbitrary response, such as a lever press, is reinforced by the presentation of small amounts...

The effects of response cost and species-typical behaviors on a daily time-place learning task.

Science.gov (United States)

Deibel, Scott H; Thorpe, Christina M

2013-03-01

Two theories that have been hypothesized to mediate acquisition in daily time-place learning (TPL) tasks were investigated in a free operant daily TPL task: the response cost hypothesis and the species-typical behavior hypothesis. One lever at the end of one of the choice arms of a T-maze provided food in the morning, and 6 h later, a lever in the other choice arm provided food. Four groups were used to assess the effect of two possible sources of response cost: physical effort of the task and costs associated with foraging ecology. One group was used to assess the effect of explicitly allowing for species-typical behaviors. If only first arm choice data were considered, there was little evidence of learning. However, both first press and percentage of presses on the correct lever prior to the first reinforcement revealed evidence of TPL in most rats tested. Unexpectedly, the high response cost groups for both of the proposed sources did not perform better than the low response cost groups. The groups that allowed animals to display species-typical behaviors performed the worst. Skip session probe trials confirmed that the majority of the rats that acquired the task were using a circadian timing strategy. The results from the present study suggest that learning in free operant daily TPL tasks might not be dependent on response cost.

Behavioural effects of chronic manipulations of dietary choline in senescent rats.

Science.gov (United States)

Fundaro, A; Paschero, A

1990-01-01

1. Senescent rats were maintained on choline-deficient and choline-enriched diets. The modifications in rat behaviour caused by the chronic manipulations of dietary choline were studied in two schedules of operant conditioning. 2. In the "periodic conditioning" test, the schedule of reinforcement, in a 100 min trial, was changed from a fixed ratio to a fixed interval schedule. In the "reversal" test the contingency for food delivery was switched four times from one lever to the other in a two lever Skinner box. 3. In the "periodic conditioning" test, the choline enriched group (430 mg/Kg/day) showed the same reduction of responses/reinforcement as controls, from the beginning to the end of trial; in the same group the time course reduction of responses/reinforcement became significant earlier than in the control group. The deficient-choline group in the last 40 min of "periodic conditioning" trial gave a reduction of responses/reinforcement greater than controls and one rat in the group did not learn the change of experimental schedule and extinguished its operant behaviour. 4. In the "reversal" test, the choline-enriched diet (320 mg/Kg/day) improved the reinforced responses in the IV reversal; one rat of the deficient-choline group could not learn the new operant schedule since the first reversal and continued to respond on the same lever during the whole of the test.

The role of GABAB receptors in morphine self-administration

Directory of Open Access Journals (Sweden)

Effat Ramshini

2013-01-01

Full Text Available Background: There is only little information about the effects of GABA receptors agonist and antagonist on morphine self-administration. Present study was designed to assess role of GABAB receptors in the regulation of morphine-reinforced self-administration. Methods: This study was performed in four groups of rats: (1 Saline group, which received saline in the self-administration session. (2 Morphine group, which received morphine in saline solution in the self-administration session. (3 Baclofen + Morphine group, which received both baclofen 20 min before self- administration test and morphine in the self-administration session. (4 Phaclofen + Morphine group, which received both phaclofen 20 min before self- administration test and morphine in the self-administration session. The number of lever pressing and self-infusion were recorded. Results: Morphine significantly increased the number of active lever pressing dose dependently in self-administration session in comparative with saline group. Administration of baclofen, 20 min before morphine self-administration produced significant decrease in the initiation of morphine self-administration during all session. Conversely, pre-treatment of phaclofen increased the number of active lever pressing and self-infusion in this test. Conclusion: Our results indicated a short-term treatment by baclofen, reduced morphine-maintenance response in a dose-dependent manner, suggesting that GABAB receptor agonists could be useful for reversing the neuroadaptations related to opiates.

Cue-induced reinstatement of ethanol seeking in Sardinian alcohol-preferring rats.

Science.gov (United States)

Maccioni, Paola; Orrú, Alessandro; Korkosz, Agnieszka; Gessa, Gian Luigi; Carai, Mauro A M; Colombo, Giancarlo; Bienkowski, Przemyslaw

2007-02-01

The purpose of the present study was to characterize cue-induced reinstatement of ethanol seeking in selectively bred Sardinian alcohol-preferring (sP) rats trained to lever press for ethanol in 30-min self-administration sessions. Four responses on an "active" lever led to presentation of 0.1 ml of 15% (vol/vol) ethanol by a liquid dipper and concurrent activation of a set of discrete light and auditory cues. In a 70-min extinction/reinstatement session, responding was first extinguished for 60 min. Subsequently, different stimuli were delivered in a noncontingent manner and reinstatement of nonreinforced responding was assessed. Fifteen presentations of the ethanol-predictive stimulus complex, including the dipper cup containing 5 or 15% ethanol, potently reinstated responding on the previously active lever. The magnitude of reinstatement increased with the number of stimulus presentations and concentration of ethanol presented by the dipper cup. Fifteen presentations of the ethanol-predictive stimulus complex, including the dipper cup filled with water (0% ethanol), did not produce any reinstatement. These results indicate that (1) noncontingent presentations of the ethanol-predictive stimulus complex may reinstate ethanol seeking in sP rats and (2) the orosensory properties of ethanol may play an important role in reinstatement of ethanol seeking in sP rats. The latter finding concurs with clinical observations that odor and taste of alcoholic beverages elicit immediate craving responses in abstinent alcoholics.

49 CFR Appendix A to Part 180 - Internal Self-closing Stop Valve Emergency Closure Test for Liquefied Compressed Gases

Science.gov (United States)

2010-10-01

... internal self-closing stop valve's lever, piston, or other valve indicator has moved to the closed position. 2. On pump-actuated pressure differential internal valves, the three-way toggle valve handle or its...

Multifunctional materials for tribological applications

CERN Document Server

Wood, Robert J K

2015-01-01

""Professor Wood's excellent book is a must-read for all those with an interest in surface engineering and tribology. He has brought together leading experts in their field to produce a comprehensive compilation of topics highly relevant to today's needs. The book will also appeal to non-tribologists, especially engineers and scientists, developing new systems and looking for up-to-date information on advanced materials and coatings.""-Mr. Keith Harrison, The Institute of Materials, Minerals and Mining, UK""A group of well-written, informative ar

Joyride: a Jerwood Open Forest Commission

OpenAIRE

Harrison, K

2017-01-01

Joyride is a community-focused live event, which brings together personal and social narratives around the automotive industry in the West Midlands, informed by the artists’ upbringing in the heavily post-industrialised Black Country.\\ud \\ud On 30 September at Cannock Chase Forest’s Tackeroo site, Keith Harrison will release a life-size clay replica of the final Rover 75 to leave the Longbridge car plant in Birmingham, down a temporary 10-metre ramp. Joyride will commence at 5.30pm with a pub...

Skewness of the cosmic microwave background temperature fluctuations due to the non-linear gravitational instability

International Nuclear Information System (INIS)

Munshi, D.; Souradeep, T.; Starobinsky, A.A.

1995-01-01

The skewness of the temperature fluctuations of the cosmic microwave background (CMB) produced by initially Gaussian adiabatic perturbations with the flat (Harrison-Zeldovich) spectrum, which arises due to non-linear corrections to a gravitational potential at the matter-dominated stage, is calculated quantitatively. For the standard CDM model, the effect appears to be smaller than expected previously and lies below the cosmic variance limit even for small angles. The sign of the skewness is opposite to that of the skewness of density perturbations. (author)

Understanding National Trajectories of Regionalism Through Legitimate, Political and Administrative Capital

DEFF Research Database (Denmark)

Larsen, Peter Wilgaard; Ferry, Martin

2015-01-01

,2002 & Tomaney, 2002), New Regionalism (Bukve, 2005; Söderbaum et al, 2005; Wheeler, 2002; Tomaney et al,2002; Webb & Collis, 2000 & Hettne, 1999), New Italian Regionalism (Salone, 2010), English Regionalism(Mawson, 2007 & Bond, 2004), City-regionalism (Harrison, 2012 & 2010) or Fragmented Regionalism...... for newthoughts. Stage 2 and 3 gives policy entrepreneurs the opportunity of airing solutions on experienced problemsand realise ideas. At stage 4, institutional elements are created to institutionalise the chosen idea of thepreceding stages. To reach stage 5’s full institutionalisation, the institution...

D1 receptors in the nucleus accumbens-shell, but not the core, are involved in mediating ethanol-seeking behavior of alcohol-preferring (P) rats.

Science.gov (United States)

Hauser, S R; Deehan, G A; Dhaher, R; Knight, C P; Wilden, J A; McBride, W J; Rodd, Z A

2015-06-04

Clinical and preclinical research suggest that activation of the mesolimbic dopamine (DA) system is involved in mediating the rewarding actions of drugs of abuse, as well as promoting drug-seeking behavior. Inhibition of DA D1 receptors in the nucleus accumbens (Acb) can reduce ethanol (EtOH)-seeking behavior of non-selective rats triggered by environmental context. However, to date, there has been no research on the effects of D1 receptor agents on EtOH- seeking behavior of high alcohol-preferring (P) rats following prolonged abstinence. The objective of the present study was to examine the effects of microinjecting the D1 antagonist SCH 23390 or the D1 agonist A-77636 into the Acb shell or Acb core on spontaneous recovery of EtOH-seeking behavior. After 10 weeks of concurrent access to EtOH and water, P rats underwent seven extinction sessions (EtOH and water withheld), followed by 2 weeks in their home cages without access to EtOH or operant sessions. In the 2nd week of the home cage phase, rats were bilaterally implanted with guide cannula aimed at the Acb shell or Acb core; rats were allowed 7d ays to recover before EtOH-seeking was assessed by the Pavlovian Spontaneous Recovery (PSR) model. Administration of SCH23390 (1μg/side) into the Acb shell inhibited responding on the EtOH lever, whereas administration of A-77636 (0.125μg/side) increased responding on the EtOH lever. Microinfusion of D1 receptor agents into the Acb core did not alter responding on the EtOH lever. Responses on the water lever were not altered by any of the treatments. The results suggest that activation of D1 receptors within the Acb shell, but not Acb core, are involved in mediating PSR of EtOH-seeking behavior of P rats. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

ICTs, Economic Growth and Poverty | IDRC - International ...

International Development Research Centre (IDRC) Digital Library (Canada)

ICTs, Economic Growth and Poverty ... new information and communication technologies (ICTs) as a lever for economic and social development. ... Socially equitable climate action is essential to strengthen the resilience of all people, without ...

Design and multi-objective optimization for a broad self-amplified 2 ...

Indian Academy of Sciences (India)

Thanh-Phong Dao

2017-09-01

Sep 1, 2017 ... Unlike traditional one-lever mechanisms, a new double- ... type is then manufactured via wire electrical discharge machining process. .... results indicate that all flexure hinges have a mesh much ...... frequency and phase.

Uighurerne 1

DEFF Research Database (Denmark)

Elling, Rasmus Christian

2005-01-01

Uighurerne, som lever i det nordvestlige Kina, har været udsat for årtiers hård kommunistisk indoktrinering og etnisk diskrimination, og regionens fortalere for autonomi forfølges. Udgivelsesdato: 13/10...

Assessing stationary laboratory test methods for underground mining vehicles to determine their suitability in replicating real-world emissions

CSIR Research Space (South Africa)

Wattrus, MC

2016-09-01

Full Text Available Fuel, engine and after-treatment technologies are powerful levers to reduce diesel particulate matter emissions, however these benefits can only be guaranteed through routine maintenance and equipment monitoring. Portable emissions measurement...

ADMINISTRATIVE INSTRUMENTS IN IMPLEMENTING FUNCTIONAL STRATEGIES COMPETITIVENESS MANAGEMENT

Directory of Open Access Journals (Sweden)

Iryna Stankovska

2017-03-01

Full Text Available The article explores the use of  аdministrative instruments in implementing functional strategies competitiveness management. Due to providing strategic financial management competitiveness the use of administrative levers of control in the formulation and implementation of financial strategies were investigated. System of financial policies forming by individual policies of  general financial strategy, which is an administrative levers of influence on implementation strategies, was proposed. Structure strategic alternatives of financial and investment strategy implementation based on the decomposition and decision tree was formed. To select strategic alternatives, to identify strategic gaps and evaluate deviations from specified target markers in the implementation of financial policies using GAP-analysis that is a tool of management analysis was proposed. Key words: functional strategy, financial strategy, competitiveness management, financial policy, administrative instruments, GAP-analysis.

World Class Facilities Management

DEFF Research Database (Denmark)

Malmstrøm, Ole Emil; Jensen, Per Anker

2013-01-01

Alle der med entusiasme arbejder med Facilities Management drømmer om at levere World Class. DFM drømmer om at skabe rammer og baggrund for, at vi i Danmark kan bryste os at være blandt de førende på verdensplan. Her samles op på, hvor tæt vi er på at nå drømmemålet.......Alle der med entusiasme arbejder med Facilities Management drømmer om at levere World Class. DFM drømmer om at skabe rammer og baggrund for, at vi i Danmark kan bryste os at være blandt de førende på verdensplan. Her samles op på, hvor tæt vi er på at nå drømmemålet....

A commutator

Energy Technology Data Exchange (ETDEWEB)

Siokhara, T.; Khibino, Y.; Tiaki, K.; Vatanabe, K.

1981-06-22

Switching of a microswitch, which switches the output electrical circuits of a unit, which supports control of industrial processes in time, is accomplished by a two arm rocking lever. The lever is driven by a cam mechanism, linked with a complex, multistage mechanical drive, which includes cylindrical gear drives and cam couplings for linkage, rotated by a synchronous electric micromotor. The unit is equipped with two subassemblies for establishment of process control: in functions of conditional time and functions of the times of day. The dials of the subassemblies for time establishment, located on the facial panel of the instrument, are equipped with arrows for the assigners with illumination and signal lamps. The lights control the mode of electric power for the instrument and the modes of the output circuits of the commutating subassembly.

A model for chemically-induced mechanical loading on MEMS

DEFF Research Database (Denmark)

Amiot, Fabien

2007-01-01

The development of full displacement field measurements as an alternative to the optical lever technique to measure the mechanical response for microelectro-mechanical systems components in their environment calls for a modeling of chemically-induced mechanical fields (stress, strain, and displac......The development of full displacement field measurements as an alternative to the optical lever technique to measure the mechanical response for microelectro-mechanical systems components in their environment calls for a modeling of chemically-induced mechanical fields (stress, strain...... of the system free energy and its dependence on the surface amount. It is solved in the cantilever case thanks to an asymptotic analysis, and an approached closed-form solution is obtained for the interfacial stress field. Finally, some conclusions regarding the transducer efficiency of cantilevers are drawn...

Search Results | Page 732 | IDRC - International Development ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 7311 - 7320 of 9601 ... Equity Gauge Zambia : Enhancing Governance, Equity and Health ... Tax policies in developing countries, and indeed around the world, are under ... (ICTs) as a lever for economic and social development. Project.

Cross connecting absorber module inlets of multiple boiler units

International Nuclear Information System (INIS)

Cirillo, A.J.; Sperber, P.K.; Belavadi, V.N.; Mukherji, A.

1991-01-01

The retrofitting of scrubbers downstream of existing balanced draft boilers is often accomplished by the addition of induced draft (ID) booster fans. By creating a common plenum between the ID fans and the ID booster fans of two or more boiler-absorber trains, absorber module capacity may be shared among multiple boiler units. At Harrison Power Station, three (3) 4,900,000 lb/hour boilers (640 MWe Gross) will be linked through a common plenum. This sharing capability precludes the need to add standby module capacity, thereby saving capital dollars and keeping project critical path schedules, which typically run through absorber procurement and construction, to a minimum. Through damper placement in the ductwork cross connections, unitized boiler-absorber module operation or common plenum operation may be obtained, thus providing both operational flexibility and reliability. Additionally, open plenum operation allows the removal of an absorber unit from service, while keeping its associated boiler on line, thereby precluding 'cold starts' and maintaining overall unit availabilities. As either unitized or common plenum operation is possible with the cross connection, the furnace draft control systems of each boiler must be examined for varying load operation and trip conditions. This paper addresses the means by which to analyze such cross connection operational scenarios while maintaining compliance with furnace flame out safety guidelines, and will discuss the physical design considerations, ramifications and benefits of same, with select emphasis on what is being implemented at the Harrison Power Station

Effects of buffer composition, pH and temperature on oxygen binding ...

African Journals Online (AJOL)

1989-03-14

Mar 14, 1989 ... best stability against methaemoglobin formation. The highest ... regarding their capacity to hold water or to keep the temperature, pH ... pore (Lever & Bekius 1965). ..... fore meaningless and were discarded when the slope of.

Knowledge management and economic integration in Southern Africa: unpacking the contribution of a regional spatial perspective in building regional competitiveness and prosperity

CSIR Research Space (South Africa)

Chakwizira, J

2009-05-01

Full Text Available spatial planning office under-girded by a southern African spatial development perspective protocol. The office could become a fountain of enhanced spatial knowledge management and a platform for generating economic integration intervention levers...

Immunization of baboons with attenuated schistosomula of Schistosoma haematobium: levels of protection induced by immunization with larvae irradiated with 20 and 60 krad

International Nuclear Information System (INIS)

Harrison, R.A.; Bickle, Q.D.; Sturrock, R.F.; Taylor, M.G.; Webbe, G.; Kiare, S.; James, E.R.; Andrews, B.J.

1990-01-01

The authors have demonstrated that baboons can be immunized with S. haemotobium schistosomula irradiated with 20 krad in a regimen that induces 90% protection. While this high level of protection has stimulated a discussion on the feasibility of a human volunteer trial (Von Lichtenberg, 1985), results of further studies particularly on (i) the pathogensis of immunization per se (Byram et al., 1989), (ii) the longevity of protection, and (iii) the protective efficacy of cryopreserved irradiated S. haemotobium schistosomula (R. Harrison et al., in preparation), prevent recommending this form of vaccination for human application. (author)

Brand Africa

DEFF Research Database (Denmark)

Richey, Lisa Ann; Ponte, Stefano

2012-01-01

a. Lisa Ann Richey, Roskilde University and Stefano Ponte, Danish Institute for International Studies - Brand Aid and Africa b. Fantu Cheru, Nordic Africa Institute - The Right to Consume: Compassion and the Intricate New Phase of Capitalism and Africa c. Rita Abrahamsen, University of Ottawa...... - Africa in a Global Political Economy of Symbolic Goods d. Graham Harrison, University of Sheffield - Images and Representations of Africa: Old, New and Beyond e. Claire Mercer, London School of Economics and Political Science - The Privatisation of Aid? f. Dan Brockington, University of Manchester...

Establishing and maintaining a satellite campus connected by synchronous video conferencing.

Science.gov (United States)

Fox, Brent I; McDonough, Sharon L; McConatha, Barry J; Marlowe, Karen F

2011-06-10

Pharmacy education has experienced substantial growth in the number of new schools and existing schools establishing satellite campuses. Several models have previously been used to connect primary and satellite campuses. We describe the Auburn University Harrison School of Pharmacy's (AUHSOP's) experiences using synchronous video conferencing between the Auburn University campus in Auburn and a satellite campus in Mobile, Alabama. We focus on the technology considerations related to planning, construction, implementation, and continued use of the various resources that support our program. Students' perceptions of their experiences related to technology also are described.

Third-order WKBJ eigenvalues for Lennard-Jones and Varshni V potentials

International Nuclear Information System (INIS)

Kesarwani, R.N.; Varshni, Y.P.

1978-01-01

The WKBJ method is applied to the third order for obtaining the eigenvalues for the fifth potential of Varshni, and the relevant integrals are analytically evaluated. Numerical results are obtained for the Lennard-Jones Potential, which is a special case of the Varshni V potential, and are compared to the results of Harrison and Bernstein obtained by a numerical integration of the wave equation. Error estimates are made. It is shown that for diatomic potentials, the Langer correction is not needed if the WKBJ approximation is carried to second and higher orders. (author)

Bodies at sea

DEFF Research Database (Denmark)

Pedersen, Michael Haldrup

Numerous are the signs and markers at museums and heritage sites instructing bodies to “stop, look and listen” (Ingold 2000: 243). Screens to be watched, gadgets and touch sensitive switches to be activated, films to be gazed at in silent concentration or interactive spectacles to participate in...... in tourism. Drawing in particular on performance based readings of heritage consumption and tourism (Haldrup and Larsen 2010; Waterton and Watson 2014; Haldrup and Bærenholdt 2015) as well as developments in non-representational theory and affect theory (Anderson and Harrison 2010; Massumi 2014; Timm Knudsen...

Lie symmetry analysis and reduction for exact solution of (2+1)-dimensional Bogoyavlensky-Konopelchenko equation by geometric approach

Science.gov (United States)

Ray, S. Saha

2018-04-01

In this paper, the symmetry analysis and similarity reduction of the (2+1)-dimensional Bogoyavlensky-Konopelchenko (B-K) equation are investigated by means of the geometric approach of an invariance group, which is equivalent to the classical Lie symmetry method. Using the extended Harrison and Estabrook’s differential forms approach, the infinitesimal generators for (2+1)-dimensional B-K equation are obtained. Firstly, the vector field associated with the Lie group of transformation is derived. Then the symmetry reduction and the corresponding explicit exact solution of (2+1)-dimensional B-K equation is obtained.

The impact of bone development on final carcass weight

DEFF Research Database (Denmark)

Tatara, M.R.; Tygesen, Malin Plumhoff; Sawa-Wojtanowicz, B.

2006-01-01

Proper development and function of the skeleton is crucial for the optimal growth of an organism, with rapid growth rates often resulting in skeletal disorders in farm animals. Yet, despite clear benefits for breed selection and animal welfare (HARRISON et al., 2004), the impact of bone development...... was removed and its parameters correlated with carcass weight. Results suggest that both femur length and femur weight act as good predictors of final carcass weight in lambs. However, no effect of paternal genetics, on the femur to carcass correlations, was noted....

Solid state theory

CERN Document Server

Harrison, Walter A

2011-01-01

""A well-written text . . . should find a wide readership, especially among graduate students."" - Dr. J. I. Pankove, RCA.The field of solid state theory, including crystallography, semi-conductor physics, and various applications in chemistry and electrical engineering, is highly relevant to many areas of modern science and industry. Professor Harrison's well-known text offers an excellent one-year graduate course in this active and important area of research. While presenting a broad overview of the fundamental concepts and methods of solid state physics, including the basic quantum theory o

Deterring Malicious Behavior in Cyberspace

Science.gov (United States)

2015-01-01

www.armed-services.senate .gov/imo/media/doc/14-16%20-%203-11-14.pdf. 31. Zachary Fryer- Biggs , “US Cyber Moves beyond Protection,” Defense News, 16...ed., ed. Schuyler Foerster and Edward Wright (Baltimore, MD: Johns Hopkins University Press, 1990), 47–51. 34. Roger G. Harrison, Deron R. Jackson...ccsfiles.blob.core.windows.net/web-site/file/81d5ad9c89d242a7a555658e604 fdc43/Critical%20Controls%20v4.1.pdf. 56. John Pescatore and Tony Sager, Critical Security

Near field and altered zone environmental report Volume I: technical bases for EBS design

Energy Technology Data Exchange (ETDEWEB)

Wilder, D. G., LLNL

1997-08-01

This report presents an updated summary of results for the waste package (WP) and engineered barrier system (EBS) evaluations, including materials testing, waste-form characterization, EBS performance assessments, and near-field environment (NFE) characterization. Materials testing, design criteria and concept development, and waste-form characterization all require an understanding of the environmental conditions that will interact with the WP and EBS. The Near-Field Environment Report (NFER) was identified in the Waste Package Plan (WPP) (Harrison- Giesler, 1991) as the formal means for transmitting and documenting this information.

Environmental Assessment: Hurricane Katrina Recovery and Installation Development at Keesler Air Force Base, Mississippi

Science.gov (United States)

2006-12-01

ly Sweeney Jef fe rso n D avi s Ze ro M a u villa Foulois Fe che t Cabell Esposito Percy Thunderbolt James Ar nol d Pine Lawn Monroe W all Bilm arsan... Jackson counties in Mississippi. These three counties encompass 1,785 square miles of land area and comprise the entire coastline of Mississippi along the...24.2% Hancock County 46,711 11.6% 15.7% 23.4% Harrison County 193,810 29.8% 16.5% 25.7% Jackson County 135,940 27.6% 15.0% 25.8% Biloxi MSA 376,461

Skulle det være en Foster eller en Toyota?

DEFF Research Database (Denmark)

Vibæk, Kasper Sánchez

2006-01-01

Japanske husproducenter leverer nøglefærdige huse fra fabrik. De styrede produktionsforhold og det at der produceres ud fra en katalog tankegang har betydning for det arkitektoniske udtryk. Artiklen beskriver og analyserer konsekvenserne af dette....

Basolateral amygdala supports the maintenance of value and effortful choice of a preferred option.

Science.gov (United States)

Hart, Evan E; Izquierdo, Alicia

2017-02-01

The basolateral amygdala (BLA) is known to be involved in appetitive behavior, yet its role in cost-benefit choice of qualitatively different rewards (more/less preferred), beyond magnitude differences (larger/smaller), is poorly understood. We assessed the effects of BLA inactivations on effortful choice behavior. Rats were implanted with cannulae in BLA and trained to stable lever pressing for sucrose pellets on a progressive ratio schedule. Rats were then introduced to a choice: chow was concurrently available while they could work for the preferred sucrose pellets. Rats were infused with either vehicle control (aCSF) or baclofen/muscimol prior to test. BLA inactivations produced a significant decrease in lever presses for sucrose pellets compared to vehicle, and chow consumption was unaffected. Inactivation had no effect on sucrose pellet preference when both options were freely available. Critically, when lab chow was not concurrently available, BLA inactivations had no effect on the number of lever presses for sucrose pellets, indicating that primary motivation in the absence of choice remains intact with BLA offline. After a test under specific satiety for sucrose pellets, BLA inactivation rendered animals less sensitive to devaluation relative to control. The effects of BLA inactivations in our task are not mediated by decreased appetite, an inability to perform the task, a change in food preference, or decrements in primary motivation. Taken together, BLA supports the specific value and effortful choice of a preferred option. © 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.