KINEMATIC ANALYSIS OF LINE-OUT THROWING IN ELITE INTERNATIONAL RUGBY UNION

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Mark G.L. Sayers

2011-09-01

Full Text Available The rugby union line-out is a key aspect of game play and involves players from both teams contesting for the ball after it has been thrown in from the side line. Successful lines-out throws require the ball to be delivered accurately to the hands of a jumping and/or lifted team mate (approximately 3-3.5 m off the ground over distances of between 5- 18 m. Previous research has suggested considerable inter and intra-individual differences in the throwing techniques of international level players. Accordingly, this project investigated the interrelationships between accuracy and the line-out throwing characteristics of three elite international rugby players, and then analyzed whether these changed for throws over increasing length. Three-dimensional (3D data were developed from video footage (50 Hz of three elite international subjects for 30 throws over three distances (6 m, 10 m, and 15 m. Results showed notable differences between subjects in many variables at each of the key throw phases. However, several variables such as the degree of trunk flexion at the end of the backswing and at ball release, coupled with elbow flexion angle at ball release remained constant as throw length increased. All subjects exhibited high levels of consistency in movement patterns across all throw lengths. Findings indicated that these high performance line-out throwers shared several common characteristics that will provide useful guides in the development of training programs

Effect of Core Training on Male Handball Players' Throwing Velocity.

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Manchado, Carmen; García-Ruiz, José; Cortell-Tormo, Juan Manuel; Tortosa-Martínez, Juan

2017-02-01

In handball, throwing velocity is considered to be one of the essential factors in achieving the ultimate aim of scoring a goal. The objective of the present study was to analyze the effect of a core training program on throwing velocity in 30 handball players (age 18.7 ± 3.4 years, body height 179.3 ± 7.0 cm, body mass 78.9 ± 7.7 kg), 16 of whom were in the junior category and 14 of whom were in the senior category. The 30 players were randomly divided into two groups, the control group (n = 15) and the experimental group (n = 15). For a period of ten weeks, both groups attended their regular handball training sessions (four per week), but in addition, the experimental group participated in a program specifically aimed at progressively strengthening the lumbo-pelvic region and consisting of seven exercises performed after the general warm-up in each regular session. Pre- and post-tests were carried out to analyze each player's throwing velocity from different throwing positions and thus assess the effects of this specific training program. Statistically significant differences (p ≤ 0.05) in throwing velocity were observed between the experimental group, which presented a percentage improvement of 4.5%, and the control group, which did not show any improvement. The results seem to indicate that an increase in the strength and stability of the lumbo-pelvic region can contribute to an improvement in the kinetic chain of the specific movement of throwing in handball, thus, increasing throwing velocity.

Effect of Core Training on Male Handball Players’ Throwing Velocity

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García-Ruiz, José; Cortell-Tormo, Juan Manuel; Tortosa-Martínez, Juan

2017-01-01

Abstract In handball, throwing velocity is considered to be one of the essential factors in achieving the ultimate aim of scoring a goal. The objective of the present study was to analyze the effect of a core training program on throwing velocity in 30 handball players (age 18.7 ± 3.4 years, body height 179.3 ± 7.0 cm, body mass 78.9 ± 7.7 kg), 16 of whom were in the junior category and 14 of whom were in the senior category. The 30 players were randomly divided into two groups, the control group (n = 15) and the experimental group (n = 15). For a period of ten weeks, both groups attended their regular handball training sessions (four per week), but in addition, the experimental group participated in a program specifically aimed at progressively strengthening the lumbo-pelvic region and consisting of seven exercises performed after the general warm-up in each regular session. Pre- and post-tests were carried out to analyze each player’s throwing velocity from different throwing positions and thus assess the effects of this specific training program. Statistically significant differences (p ≤ 0.05) in throwing velocity were observed between the experimental group, which presented a percentage improvement of 4.5%, and the control group, which did not show any improvement. The results seem to indicate that an increase in the strength and stability of the lumbo-pelvic region can contribute to an improvement in the kinetic chain of the specific movement of throwing in handball, thus, increasing throwing velocity. PMID:28469756

Sport-Specific Training Targeting the Proximal Segments and Throwing Velocity in Collegiate Throwing Athletes

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Palmer, Thomas; Uhl, Timothy L.; Howell, Dana; Hewett, Timothy E.; Viele, Kert; Mattacola, Carl G.

2015-01-01

Context The ability to generate, absorb, and transmit forces through the proximal segments of the pelvis, spine, and trunk has been proposed to influence sport performance, yet traditional training techniques targeting the proximal segments have had limited success improving sport-specific performance. Objective To investigate the effects of a traditional endurance-training program and a sport-specific power-training program targeting the muscles that support the proximal segments and throwing velocity. Design Randomized controlled clinical trial. Setting University research laboratory and gymnasium. Patients or Other Participants A total of 46 (age = 20 ± 1.3 years, height = 175.7 ± 8.7 cm) healthy National Collegiate Athletic Association Division III female softball (n = 17) and male baseball (n = 29) players. Intervention(s) Blocked stratification for sex and position was used to randomly assign participants to 1 of 2 training groups for 7 weeks: a traditional endurance-training group (ET group; n = 21) or a power-stability–training group (PS group; n = 25). Mean Outcome Measure(s) The change score in peak throwing velocity (km/h) normalized for body weight (BW; kilograms) and change score in tests that challenge the muscles of the proximal segments normalized for BW (kilograms). We used 2-tailed independent-samples t tests to compare differences between the change scores. Results The peak throwing velocity (ET group = 0.01 ± 0.1 km/h/kg of BW, PS group = 0.08 ± 0.03 km/h/kg of BW; P < .001) and muscle power outputs for the chop (ET group = 0.22 ± 0.91 W/kg of BW, PS group = 1.3 ± 0.91 W/kg of BW; P < .001) and lift (ET group = 0.59 ± 0.67 W/kg of BW, PS group = 1.4 ± 0.87 W/kg of BW; P < .001) tests were higher at postintervention in the PT than in the ET group. Conclusions An improvement in throwing velocity occurred simultaneously with measures of muscular endurance and power after a sport-specific training regimen targeting the proximal segments

Simulation and experimental research on line throwing rocket with flight

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Wen-bin Gu

2014-06-01

Full Text Available The finite segment method is used to model the line throwing rocket system. A dynamic model of line throwing rocket with flight motion based on Kane's method is presented by the kinematics description of the system and the consideration of the forces acting on the system. The experiment designed according to the parameters of the dynamic model is made. The simulation and experiment results, such as range, velocity and flight time, are compared and analyzed. The simulation results are basically agreed with the test data, which shows that the flight motion of the line throwing rocket can be predicted by the dynamic model. A theoretical model and guide for the further research on the disturbance of rope and the guidance, flight control of line throwing rocket are provided by the dynamic modeling.

Strength and Power Correlates of Throwing Velocity on Subelite Male Cricket Players.

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Freeston, Jonathan L; Carter, Thomas; Whitaker, Gary; Nicholls, Owen; Rooney, Kieron B

2016-06-01

Throwing velocity is an important aspect of fielding in cricket to affect run-outs and reduce the opponent's run-scoring opportunities. Although a relationship between strength and/or power and throwing velocity has been well established in baseball, water polo, and European handball, it has not been adequately explored in cricket. Consequently, this study aimed to determine the relationship between measures of strength and/or power and throwing velocity in cricket players. Seventeen male cricket players (mean ± SD; age, 21.1 ± 1.6 years; height, 1.79 ± 0.06 m; weight, 79.8 ± 6.4 kg) from an elite athlete program were tested for maximal throwing velocity from the stretch position and after a 3-meter shuffle. They were also assessed for strength and power using a range of different measures. Throwing velocity from the stretch position (30.5 ± 2.4 m·s) was significantly related to dominant leg lateral-to-medial jump (LMJ) distance (r = 0.71; p velocity and medicine ball chest pass (MB CP) distance (r = 0.67; p bench press strength (p = 0.90), height (p = 0.33), or weight (p = 0.29). Multiple regression analysis revealed that dominant MB Rot and MB CP explained 66% of the variance. The results were similar for velocity after a shuffle step (31.8 ± 2.1 m·s); however, VJ height reached statistical significance (r = 0.51; p ≤ 0.05). The multiple regression was also similar with MB Rot and MB CP explaining 70% of the variance. The cricketers in this study threw with greater velocity than elite junior and subelite senior cricketers but with lower velocities than elite senior cricketers and collegiate level and professional baseball players. This is the first study to demonstrate a link between strength and/or power and throwing velocity in cricket players and highlight the importance of power development as it relates to throwing velocity. Exercises that more closely simulated the speed (body weight jumps and medicine ball throws) or movement pattern (shoulder IR

Relationship among maximal grip, throwing velocity and anthropometric parameters in elite water polo players.

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Ferragut, C; Vila, H; Abraldes, J A; Argudo, F; Rodriguez, N; Alcaraz, P E

2011-03-01

As independent aspects, body size, body composition, and physiological performance of elite athletes have aroused the interest of sports scientists but, unfortunately, studies that combine these aspects are scarcely avalaible in water polo. The aim of the present study was to: 1) to develop an anthropometric profile of highly skilled male Water Polo players, and 2) to identify significant relationships between these features and overhead throwing velocity in highly skilled male water polo players. Thirteen male water polo players, with a mean age of 26.10±4.82, were recruited from the Spanish Water Polo team and an anthropometric assessment on all of them was carried out. Throwing velocity was evaluated in three different situations from the 5 m-penalty line on the center of the water polo goal: A) throwing without a defender nor a goalkeeper; B) throwing with a goalkeeper only, and C) 3) armfuls running shot with goalkeeper. Maximal handgrip was also tested. Biacromial breadth shows a significative correlation with hand grip in water polo players (r=0.792; P=0.001) and also correlates with Throwing velocity (r=0.716; P<0.001). Biepicondylar femur breadth correlates significatively with hand grip (r=0.727; P<0.05) and also with throwing velocity in "throwing with goalkeeper" situation (r=0.664; P<0.05). Hand grip shows a significant correlation with throwing velocity in "throwing with goalkeeper" situation (r=0.603; P<0.05). In conclusion, body mass aspects are not related with throwing velocity in highly skilled Water Polo players. Maximal hand grip is related with throwing velocity in "throwing with goalkeeper" situation. More investigations about water polo are necessary.

BASIC TECHNICAL SKILLS (THROWS IN 17-19-YEAR-OLD JUDOKAS

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Wladyslaw Jagiello

2014-12-01

Full Text Available Purpose: The purpose of the research was to determine basic technical skills (throws in 17-19-year-old judokas and the level of their performance. Material: The study involved 30 judo athletes (aged 17-19. Results: To determine the athletes’ basic technical skills (throws, an analysis of source materials and a diagnostic survey were used. To determine the level of technical skills, the method of expert assessment was applied. Statistical software package Statistica 8 was used in the statistical analysis. In the coaches’ opinion, 17-19-year-old judokas have a specific, characteristic of this age group, set of basic technical skills (throws aptly defining their technical preparation. Conclusions: The tested group of judokas exhibited the highest level of demonstrating throws of the koshi-waza (hip group, and the lowest one of the ashi-waza (foot group.

Throwing velocities, anthropometric characteristics, and efficacy indices of women's European water polo subchampions.

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Alcaraz, Pedro E; Abraldes, J Arturo; Ferragut, Carmen; Rodríguez, Nuria; Argudo, Francisco M; Vila, Helena

2011-11-01

Water polo is a team sport characterized by a high-intensity, intermittent activity, where technical and tactical aspect are of a great importance. For that reason, the main aim of this study was to define the anthropometrical characteristics, maximum isometric grip strength, training and competition throwing velocities, and the efficacy indices in female high-level water polo players. A second purpose was to examine the differences between the throwing velocities in training vs. European championships in the water polo female national team. Ten elite trained female water polo players participated in this study. Before the competitive phase of their season, the following measures were taken: standard anthropometry, static and dynamic training throwing velocities, and hand-grip dynamometry. In the competitive phase, efficacy indices, average and maximum throwing velocities from all the participants were also determined. Significant differences (p ≤ 0.05) were found between different training situations and different competitive throwing velocities. We concluded that elite female water polo players modify their throwing velocity depending if the throw is performed during training or competitive situation.

Data-Based Interval Throwing Programs for Collegiate Softball Players

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Axe, Michael J.; Windley, Thomas C.; Snyder-Mackler, Lynn

2002-01-01

Objective: To construct interval throwing programs followed by a simulated game for collegiate softball players at all positions. The programs are intended to be used as functional progressions within a comprehensive rehabilitation program for an injured athlete or to augment off-season conditioning workouts. Design and Setting: We collected data over a single season of National Collegiate Athletic Association softball at the University of Delaware and Goldey Beacom College. We observed 220 half-innings of play and 2785 pitches during data collection. Subjects: The subjects were collegiate-level softball players at all positions of play. Measurements: We recorded the number of pitches for pitchers. For catchers, we recorded the number of sprints to back up a play, time in the squat stance, throws back to the pitcher, and the perceived effort and distance of all other throws. We also collected the perceived effort and distance of all throws for infielders and outfielders. Results: Pitchers threw an average of 89.61 pitches per game; catchers were in the squat stance 14.13 minutes per game; infielders threw the ball between 4.28 times per game and 6.30 times per game; and outfielders threw distances of up to 175 feet. Conclusions: We devised the interval throwing programs from the data collected, field dimensions, the types of injuries found to occur in softball, and a general understanding of tissue healing. We designed programs that allow a safe and efficient progressive return to sport. PMID:12937435

The Acute Effects of Upper Extremity Stretching on Throwing Velocity in Baseball Throwers

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Michael Williams

2013-01-01

Full Text Available Purpose. To examine the effects of static and proprioceptive neuromuscular facilitation (PNF stretching of the shoulder internal rotators on throwing velocity. Subjects. 27 male throwers (mean age = 25.1 years old, SD = 2.4 with adequate knowledge of demonstrable throwing mechanics. Study Design. Randomized crossover trial with repeated measures. Methods. Subjects warmed up, threw 10 pitches at their maximum velocity, were randomly assigned to 1 of 3 stretching protocols (static, PNF, or no stretch, and then repeated their 10 pitches. Velocities were recorded after each pitch and average and peak velocities were recorded after each session. Results. Data were analyzed using a repeated measures ANOVA. No significant interaction between stretching and throwing velocity was observed. Main effects for time were not statistically significant. Main effects for the stretching groups were statistically significant. Discussion. Results suggest that stretching of the shoulder internal rotators did not significantly affect throwing velocity immediately after stretching. This may be due to the complexity of the throwing task. Conclusions. Stretching may be included in a thrower's warm-up without any effects on throwing velocity. Further research should be performed using a population with more throwing experience and skill.

Influence Of Opposition On Ball Velocity In The Handball Jump Throw

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Rivilla-Garcia, Jesús; Grande, Ignacio; Sampedro, Javier; Van Den Tillaar, Roland

2011-01-01

The purpose of the present study was to investigate the influence of different degrees of opposition on ball velocity in the jump throw in elite, amateur and adolescent team handball players. Thus, one hundred and nineteen elite, amateur and under 18 team handball players performed jump throws under three different conditions: 1) without opposition, 2) with the opposition of the goalkeeper and 3) with the opposition of the goalkeeper and a defensive player. The degree of opposition was found to have a negative effect on ball velocity in all three groups (p handball players in the jump throw. It indicated that an increase of external stimuli influences the execution of throwing. Experience does not seem to be a factor that can reduce the influence of these external stimuli. PMID:24150629

Multiple Wheel Throwing: And Chess Sets.

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Sapiro, Maurice

1978-01-01

A chess set project is suggested to teach multiple throwing, the creation on a potter's wheel of several pieces of similar configuration. Processes and finished sets are illustrated with photographs. (SJL)

Developmental Gender Differences for Overhand Throwing in Aboriginal Australian Children

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Thomas, Jerry R.; Alderson, Jacqueline A.; Thomas, Katherine T.; Campbell, Amity C.; Elliott, Bruce C.

2010-01-01

In a review of 46 meta-analyses of gender differences, overhand throwing had the largest gender difference favoring boys (ES greater than 3.0). Expectations for gender-specific performances may be less pronounced in female Australian Aborigines, because historical accounts state they threw for defense and hunting. Overhand throwing velocities and…

Determinant Factors of Physical Performance and Specific Throwing in Handball Players of Different Ages.

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Ortega-Becerra, Manuel; Pareja-Blanco, Fernando; Jiménez-Reyes, Pedro; Cuadrado-Peñafiel, Víctor; González-Badillo, Juan J

2018-06-01

Ortega-Becerra, M, Pareja-Blanco, F, Jiménez-Reyes, P, Cuadrado-Peñafiel, V, and González-Badillo, JJ. Determinant factors of physical performance and specific throwing in handball players of different ages. J Strength Cond Res 32(6): 1778-1786, 2018-This study aimed to analyze various fitness qualities in handball players of different ages and to determine the relationships between these parameters and throwing velocity. A total of 44 handball players participated, pooled by age groups: professional (ELITE, n = 13); under-18 (U18, n = 16); under-16 (U16, n = 15). The following tests were completed: 20-m running sprints; countermovement jumps (CMJs); jump squat to determine the load that elicited ∼20 cm jump height (JSLOAD-20 cm); a progressive loading test in full squat and bench press to determine the load that elicited ∼1 m·s (SQ-V1-LOAD and BP-V1-LOAD); and handball throwing (jump throw and 3-step throw). ELITE showed greater performance in almost all sprint distances, CMJ, JSLOAD-20 cm, and bench press strength than U18 and U16. The differences between U18 and U16 were unclear for these variables. ELITE also showed greater (p handball throwing velocity is strongly associated with lower-limb strength, although upper-limb strength, jumping and sprint capacities also play a relevant role in throwing performance, suggesting the need for coaches to include proper strength programs to improve handball players' throwing velocity.

Throwing Injuries of the Shoulder.

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McCue, Frank C., III; and Others

The majority of shoulder injuries occurring in throwing sports involve the soft tissue structures. Injuries often occur when the unit is overstretched to a point near its greatest length, involving the elastic tissues. The other injury mechanism involves the contractural unit of the muscle, which occurs near the midpoint of contractions, involving…

Kinematic Description of Elite Vs. Low Level Players in Team-Handball Jump Throw

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Wagner, Herbert; Buchecker, Michael; von Duvillard, Serge P.; Müller, Erich

2010-01-01

The jump throw is the most applied throwing technique in team- handball (Wagner et al., 2008); however, a comprehensive analysis of 3D-kinematics of the team-handball jump throw is lacking. Therefore, the purpose of our study was: 1) to measure differences in ball release speed in team- handball jump throw and anthropometric parameters between groups of different levels of performance and (2) to analyze upper body 3D-kinematics (flexion/extension and rotation) to determine significant differences between these groups. Three-dimensional kinematic data was analyzed via the Vicon MX 13 motion capturing system (Vicon Peak, Oxford, UK) from 26 male team-handball players of different performance levels (mean age: 21.2 ± 5.0 years). The participants were instructed to throw the ball (IHF Size 3) onto a target at 8 m distance, and to hit the center of a square of 1 × 1 m at about eye level (1.75 m), with maximum ball release speed. Significant differences between elite vs. low level players were found in the ball release speed (p handball players who were taller and of greater body weight have the ability to achieve a higher ball release speed in the jump throw, and that an increase in trunk flexion and rotation angular velocity improve the performance in team-handball jump throw that should result in an increase of ball release speed. Key points Team-handball players who were taller and of greater body weight have the ability to achieve a higher ball release speed. An increase in trunk flexion, trunk rotation and shoulder internal rotation angular velocity should result in an increase of ball release speed. Trunk movements are normally well observable for experienced coaches, easy correctable and therefore practical to improve the performance in team-handball jump throw of low level players during training without using complex measurement devices. PMID:24149381

Clozapine-induced dysphagia with secondary substantial weight loss.

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Osman, Mugtaba; Devadas, Vekneswaran

2016-08-19

Dysphagia is listed as a 'rare' side effect following clozapine treatment. In this case report, we describe how significant clozapine-induced dysphagia has led to significant reduction of nutritional intake with subsequent substantial weight loss. An 18-year-old single man with an established diagnosis of treatment-resistant paranoid schizophrenia recovered well on a therapeutic dose of clozapine. However, he was noted to lose weight significantly (up to 20% of his original weight) as the dose was uptitrated. This was brought about by development of dysphagia, likely to be due to clozapine. Addition of nutritional supplementary liquids and initiation of a modified behavioural dietary/swallowing programme, while repeatedly mastering the Mendelsohn manoeuvre technique, alleviated the swallowing difficulties and restored his weight. 2016 BMJ Publishing Group Ltd.

Comparison of trunk kinematics in trunk training exercises and throwing.

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Stodden, David F; Campbell, Brian M; Moyer, Todd M

2008-01-01

Strength and conditioning professionals, as well as coaches, have emphasized the importance of training the trunk and the benefits it may have on sport performance and reducing the potential for injury. However, no data on the efficacy of trunk training support such claims. The purpose of this study was to examine the maximum differential trunk rotation and maximum angular velocities of the pelvis and upper torso of participants while they performed 4 trunk exercises (seated band rotations, cross-overs, medicine ball throws, and twisters) and compare these trunk exercise kinematics with the trunk kinematics demonstrated in actual throwing performance. Nine NCAA Division I baseball players participated in this study. Each participant's trunk kinematics was analyzed while he performed 5 repetitions of each exercise in both dominant and nondominant rotational directions. Results indicated maximum differentiated rotation in all 4 trunk exercises was similar to maximum differentiated rotation (approximately 50-60 degrees) demonstrated in throwing performance. Maximum angular velocities of the pelvis and upper torso in the trunk exercises were appreciably slower (approximately 50% or less) than the angular velocities demonstrated during throwing performance. Incorporating trunk training exercises that demonstrate sufficient trunk ranges of motion and velocities into a strength and conditioning program may help to increase ball velocity and/or decrease the risk injury.

Effect of core stability training on throwing velocity in female handball players.

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Saeterbakken, Atle H; van den Tillaar, Roland; Seiler, Stephen

2011-03-01

The purpose was to study the effect of a sling exercise training (SET)-based core stability program on maximal throwing velocity among female handball players. Twenty-four female high-school handball players (16.6 ± 0.3 years, 63 ± 6 kg, and 169 ± 7 cm) participated and were initially divided into a SET training group (n = 14) and a control group (CON, n = 10). Both groups performed their regular handball training for 6 weeks. In addition, twice a week, the SET group performed a progressive core stability-training program consisting of 6 unstable closed kinetic chain exercises. Maximal throwing velocity was measured before and after the training period using photocells. Maximal throwing velocity significantly increased 4.9% from 17.9 ± 0.5 to 18.8 ± 0.4 m·s in the SET group after the training period (p core stability training using unstable, closed kinetic chain movements can significantly improve maximal throwing velocity. A stronger and more stable lumbopelvic-hip complex may contribute to higher rotational velocity in multisegmental movements. Strength coaches can incorporate exercises exposing the joints for destabilization force during training in closed kinetic chain exercises. This may encourage an effective neuromuscular pattern and increase force production and can improve a highly specific performance task such as throwing.

The observational analysis of performance in the handball ´s throwing of the Spanish promises selection

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Pablo Blanco García

2012-06-01

Full Text Available This work has as objective to analyze the efficiency of the handball´s throwings. For it, there were analyzed five matches that the lower level spanish selection disputed in an european championship. This process was realized by an observational methodology, where were evaluated different parameters related to the handball´s throwing: the model of the throw, distance, position and opposition with regard to the variable goal-no goal. The results found that the variables distance and opposition have an influence in the throwing´s efficiency, so that training of these parameters must be taken into account in the game.Key Words: Observational methodology, Spanish selection, Handball, Throwing,  Efficiency.

Reliability and validity of a talent identification test battery for seated and standing Paralympic throws.

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Spathis, Jemima Grace; Connick, Mark James; Beckman, Emma Maree; Newcombe, Peter Anthony; Tweedy, Sean Michael

2015-01-01

Paralympic throwing events for athletes with physical impairments comprise seated and standing javelin, shot put, discus and seated club throwing. Identification of talented throwers would enable prediction of future success and promote participation; however, a valid and reliable talent identification battery for Paralympic throwing has not been reported. This study evaluates the reliability and validity of a talent identification battery for Paralympic throws. Participants were non-disabled so that impairment would not confound analyses, and results would provide an indication of normative performance. Twenty-eight non-disabled participants (13 M; 15 F) aged 23.6 years (±5.44) performed five kinematically distinct criterion throws (three seated, two standing) and nine talent identification tests (three anthropometric, six motor); 23 were tested a second time to evaluate test-retest reliability. Talent identification test-retest reliability was evaluated using Intra-class Correlation Coefficient (ICC) and Bland-Altman plots (Limits of Agreement). Spearman's correlation assessed strength of association between criterion throws and talent identification tests. Reliability was generally acceptable (mean ICC = 0.89), but two seated talent identification tests require more extensive familiarisation. Correlation strength (mean rs = 0.76) indicated that the talent identification tests can be used to validly identify individuals with competitively advantageous attributes for each of the five kinematically distinct throwing activities. Results facilitate further research in this understudied area.

Simulation and experimental research on line throwing rocket with flight

OpenAIRE

Wen-bin Gu; Ming Lu; Jian-qing Liu; Qin-xing Dong; Zhen-xiong Wang; Jiang-hai Chen

2014-01-01

The finite segment method is used to model the line throwing rocket system. A dynamic model of line throwing rocket with flight motion based on Kane's method is presented by the kinematics description of the system and the consideration of the forces acting on the system. The experiment designed according to the parameters of the dynamic model is made. The simulation and experiment results, such as range, velocity and flight time, are compared and analyzed. The simulation results are basicall...

Analysis, fabrication, and field test of an advanced embedded throwing electromechanical sensing system

Energy Technology Data Exchange (ETDEWEB)

Gao, Zhen; Zhang, Dan [Beijing JiaoTong University, Beijing (China)

2014-01-15

Scientific measuring equipment is important in maintaining and further improving the daily training quality of professional athletes. In throwing sports, only kinematic information is usually recorded by several high-speed cameras, whereas the dynamic data are lacking. An advanced embedded throwing system is analyzed, fabricated, and field tested. This throwing system can be used to substitute the normal shot-put that obtains acceleration information from the upper limb when force is applied onto the device. This device has four main parts, namely, a mechanical shell, an embedded sensor, a signal processing circuit, and interface ports. The detailed design, simulation, and prototyping process are introduced in this work. The practical results obtained from the field test and feedback from users prove that the proposed throwing system is efficient for technical training and monitoring. This design provides a unique solution for the modeling and development of non-traditional, electro-mechanical sensing devices.

BASEBALL THROWING MECHANICS AS THEY RELATE TO PATHOLOGY AND PERFORMANCE - A REVIEW

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Rod Whiteley

2007-03-01

Full Text Available It is a commonly held perception amongst biomechanists, sports medicine practitioners, baseball coaches and players, that an individual baseball player's style of throwing or pitching influences their performance and susceptibility to injury. With the results of a series of focus groups with baseball managers and pitching coaches in mind, the available scientific literature was reviewed regarding the contribution of individual aspects of pitching and throwing mechanics to potential for injury and performance. After a discussion of the limitations of kinematic and kinetic analyses, the individual aspects of pitching mechanics are discussed under arbitrary headings: Foot position at stride foot contact; Elbow flexion; Arm rotation; Arm horizontal abduction; Arm abduction; Lead knee position; Pelvic orientation; Deceleration-phase related issues; Curveballs; and Teaching throwing mechanics. In general, popular opinion of baseball coaching staff was found to be largely in concordance with the scientific investigations of biomechanists with several notable exceptions. Some difficulties are identified with the practical implementation of analyzing throwing mechanics in the field by pitching coaches, and with some unquantified aspects of scientific analyses

Relationship of pectoralis major muscle size with bench press and bench throw performances.

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Akagi, Ryota; Tohdoh, Yukihiro; Hirayama, Kuniaki; Kobayashi, Yuji

2014-06-01

This study examined the relationship of muscle size indices of the pectoralis major muscle with bench press and bench throw performances in 18 male collegiate athletes. The maximal cross-sectional area (MCSAMAx) and volume (MV) of the pectoralis major muscle were determined by magnetic resonance imaging. First, subjects were tested for their one repetition maximum bench press strength (1RMBP) using a Smith machine. At a later date, subjects performed bench throws using the Smith machine with several different loads ranging from 30.0 kg to 90% of 1RMBP. Barbell positions were measured by a linear position transducer, and bench throw power was calculated using a dynamic equation. Three trials were performed for each load. In all the trials, the maximal peak power was adopted as bench throw peak power (PPBT). The 1RMBP was significantly correlated with MCSAMAx. Similarly, the correlation coefficient between MV and PPBT was significant. In contrast to the y-intercept of the MV-PPBT regression line, that of the MCSAMAx-1RMBP regression line was not significantly different from 0. These results suggested that, although the dependence on pectoralis major muscle size is slightly different between bench press strength and bench throw power, the pectoralis major muscle size has a significant impact on bench press and throw performances. Greater muscle size leads to heavier body weight, which can be a negative factor in some sports. We therefore recommend that athletes and their coaches develop training programs for improving sports performance by balancing the advantage of increased muscle size and the potential disadvantage of increased body weight.

Relationship between throwing velocity, muscle power, and bar velocity during bench press in elite handball players.

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Marques, Mario C; van den Tilaar, Roland; Vescovi, Jason D; Gonzalez-Badillo, Juan Jose

2007-12-01

The purpose of this study was to examine the relationship between ball-throwing velocity during a 3-step running throw and dynamic strength, power, and bar velocity during a concentric-only bench-press exercise in team-handball players. Fourteen elite senior male team-handball players volunteered to participate. Each volunteer had power and bar velocity measured during a concentric-only bench-press test with 26, 36, and 46 kg, as well as having 1-repetition-maximum (1-RMBP) strength determined. Ball-throwing velocity was evaluated with a standard 3-step running throw using a radar gun. Ball-throwing velocity was related to the absolute load lifted during the 1-RMBP (r = .637, P = .014), peak power using 36 kg (r = .586, P = .028) and 46 kg (r = .582, P = .029), and peak bar velocity using 26 kg (r = .563, P = .036) and 36 kg (r = .625, P = .017). The results indicate that throwing velocity of elite team-handball players is related to maximal dynamic strength, peak power, and peak bar velocity. Thus, a training regimen designed to improve ball-throwing velocity in elite male team-handball players should include exercises that are aimed at increasing both strength and power in the upper body.

Throwing behavior and mass distribution of stone selection in tufted capuchin monkeys (Cebus apella).

Science.gov (United States)

Cleveland, A; Rocca, A R; Wendt, E L; Westergaard, G C

2003-12-01

Cannell [Journal of Archaeological Science 29:335-339, 2002] argued that sex-based differences among humans in terms of the mass of chosen throwing stones could be used to infer body mass and patterns of sexual dimorphism in early hominids from Olduvai and Koobi Fora by examining the mass distributions of unaltered stone tools at those sites. We examined this hypothesis in tufted capuchin monkeys using a comparative approach, by investigating the relationships among body mass, sex, stone weight preference, and accuracy in a throwing task. The subject sample consisted of nine monkeys trained to perform an aimed-throwing task in which a food reward could be obtained by throwing a stone into a bucket. We found that 1) the subjects showed a strong mean stone mass preference; 2) the females chose heavier stones than the males, in terms of absolute mean selected stone mass and selected stone mass relative to body mass; 3) subjects threw more accurately when they used stones of preferred mass vs. stones of nonpreferred mass; and 4) overall, the males were more accurate in the throwing task than the females. We conclude that capuchins are highly selective when choosing throwing stones, and that this confers an advantage for throwing accuracy. Our results indicate that the sexually dimorphic pattern in stone mass preference observed among humans does not generalize to Cebus apella. We suggest that researchers examining this pattern in humans in an attempt to explain early hominid patterns of dimorphism and behavior should take into account not only stone weight preference, but also its adaptive advantage. Copyright 2003 Wiley-Liss, Inc.

Design and Implementation of an Embedded Digital Throwing System Based on MEMS Multiaxial Accelerometer

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Zhen GAO

2010-04-01

Full Text Available This paper presents a novel embedded digital throwing system for synchronously sensing the throwing force of shot-put athletes in real time. The three axes integrated accelerometer, as a crucial device in the force sensing system, can acquire the kinetics data along three orthogonal directions with reasonably high accuracy. The digital shot with almost the same size and weight as the standard shot for open female has been designed, fabricated and implemented. The mechanical structure, signal processing system, and human-machine interface are illuminated in detail. In this manner, the force sensing system serves as a powerful tool for coaches and sports scientists to make scientific researches on professional throwing techniques. It also provides an intuitive and reliable guidance for the throwing athletes to improve their skills.

Effect of Core Training on Male Handball Players’ Throwing Velocity

OpenAIRE

Manchado, Carmen; García-Ruiz, José; Cortell-Tormo, Juan M.; Tortosa Martínez, Juan

2017-01-01

Abstract In handball, throwing velocity is considered to be one of the essential factors in achieving the ultimate aim of scoring a goal. The objective of the present study was to analyze the effect of a core training program on throwing velocity in 30 handball players (age 18.7 ? 3.4 years, body height 179.3 ? 7.0 cm, body mass 78.9 ? 7.7 kg), 16 of whom were in the junior category and 14 of whom were in the senior category. The 30 players were randomly divided into two groups, the control g...

Frequent Immediate Knowledge of Results Enhances the Increase of Throwing Velocity in Overarm Handball Performance.

Science.gov (United States)

Štirn, Igor; Carruthers, Jamie; Šibila, Marko; Pori, Primož

2017-02-01

In the present study, the effect of frequent, immediate, augmented feedback on the increase of throwing velocity was investigated. An increase of throwing velocity of a handball set shot when knowledge of results was provided or not provided during training was compared. Fifty female and seventy-three male physical education students were assigned randomly to the experimental or control group. All participants performed two series of ten set shots with maximal effort twice a week for six weeks. The experimental group received information regarding throwing velocity measured by a radar gun immediately after every shot, whereas the control group did not receive any feedback. Measurements of maximal throwing velocity of an ordinary handball and a heavy ball were performed, before and after the training period and compared. Participants who received feedback on results attained almost a four times greater relative increase of the velocity of the normal ball (size 2) as compared to the same intervention when feedback was not provided (8.1 ± 3.6 vs. 2.7 ± 2.9%). The velocity increases were smaller, but still significant between the groups for throws using the heavy ball (5.1 ± 4.2 and 2.5 ± 5.8 for the experimental and control group, respectively). Apart from the experimental group throwing the normal ball, no differences in velocity change for gender were obtained. The results confirmed that training oriented towards an increase in throwing velocity became significantly more effective when frequent knowledge of results was provided.

Sequence-dependent rotation axis changes and interaction torque use in overarm throwing.

Science.gov (United States)

Hansen, Clint; Rezzoug, Nasser; Gorce, Philippe; Venture, Gentiane; Isableu, Brice

2016-01-01

We examined the role of rotation axes during an overarm throwing task. Participants performed such task and were asked to throw a ball at maximal velocity at a target. The purpose of this study was to examine whether the minimum inertia axis would be exploited during the throwing phases, a time when internal-external rotations of the shoulder are particularly important. A motion capture system was used to evaluate the performance and to compute the potential axes of rotation (minimum inertia axis, shoulder-centre of mass axis and the shoulder-elbow axis). More specifically, we investigated whether a velocity-dependent change in rotational axes can be observed in the different throwing phases and whether the control obeys the principle of minimum inertia resistance. Our results showed that the limbs' rotational axis mainly coincides with the minimum inertia axis during the cocking phase and with the shoulder-elbow axis during the acceleration phase. Besides these rotation axes changes, the use of interaction torque is also sequence-dependent. The sequence-dependent rotation axes changes associated with the use of interaction torque during the acceleration phase could be a key factor in the production of hand velocity at ball release.

Where Are You Throwing the Ball? I Better Watch Your Body, Not Just Your Arm!

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Antonella Maselli

2017-10-01

Full Text Available The ability to intercept or avoid a moving object, whether to catch a ball, snatch one’s prey, or avoid the path of a predator, is a skill that has been acquired throughout evolution by many species in the animal kingdom. This requires processing early visual cues in order to program anticipatory motor responses tuned to the forthcoming event. Here, we explore the nature of the early kinematics cues that could inform an observer about the future direction of a ball projected with an unconstrained overarm throw. Our goal was to pinpoint the body segments that, throughout the temporal course of the throwing action, could provide key cues for accurately predicting the side of the outgoing ball. We recorded whole-body kinematics from twenty non-expert participants performing unconstrained overarm throws at four different targets placed on a vertical plane at 6 m distance. In order to characterize the spatiotemporal structure of the information embedded in the kinematics of the throwing action about the outgoing ball direction, we introduced a novel combination of dimensionality reduction and machine learning techniques. The recorded kinematics clearly shows that throwing styles differed considerably across individuals, with corresponding inter-individual differences in the spatio-temporal structure of the thrower predictability. We found that for most participants it is possible to predict the region where the ball hit the target plane, with an accuracy above 80%, as early as 400–500 ms before ball release. Interestingly, the body parts that provided the most informative cues about the action outcome varied with the throwing style and during the time course of the throwing action. Not surprisingly, at the very end of the action, the throwing arm is the most informative body segment. However, cues allowing for predictions to be made earlier than 200 ms before release are typically associated to other body parts, such as the lower limbs and the

CONNECTION OF FUNCTIONAL ABILITIES WITH JUMPING AND THROWING ATHLETIC DISCIPLINES

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Igor Stanojević

2014-06-01

Full Text Available The aim of this study was to determine the connection between functional abilities with results of jumping and throwing athletic disciplines with athletes. The sample was taken from a population of elementary school students from Prokuplje region, 13 and 14 old, included in regular physical education classes. The sample consisted of 200 male athletes involved in the training process in sports clubs at least three times a week in addition to physical education classes. For assessment of functional abilities six functional tests were used: resting heart rate, Cooper test, heart rate in the first minute after Cooper test, heart rate in the second minute after Cooper test, systolic arterial blood pressure, diastolic arterial blood pressure. For assessment of jumping and throwing athletic disciplines four tests were used: long jump, high jump, shot put and javelin. Data analysis was performed with canonical correlation and regression analysis. The results showed a statistically significant correlation between functional abilities with all of tests in jumping and throwing athletic disciplines.

A universal throw model and its applications

NARCIS (Netherlands)

Voort, M.M. van der; Doormaal, J.C.A.M. van; Verolme, E.K.; Weerheijm, J.

2008-01-01

A deterministic model has been developed that describes the throw of debris or fragments from a source with an arbitrary geometry and for arbitrary initial conditions. The initial conditions are defined by the distributions of mass, launch velocity and launch direction. The item density in an

Time-motion analysis of goalball players in attacks: differences of the player positions and the throwing techniques.

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Monezi, Lucas Antônio; Magalhães, Thiago Pinguelli; Morato, Márcio Pereira; Mercadante, Luciano Allegretti; Furtado, Otávio Luis Piva da Cunha; Misuta, Milton Shoiti

2018-03-26

In this study, we aimed to analyse goalball players time-motion variables (distance covered, time spent, maximum and average velocities) in official goalball match attacks, taking into account the attack phases (preparation and throwing), player position (centres and wings) and throwing techniques (frontal, spin and between the legs). A total of 365 attacks were assessed using a video based method (2D) through manual tracking using the Dvideo system. Inferential non-parametric statistics were applied for comparison of preparation vs. throwing phase, wings vs. centres and, among the throwing techniques, frontal, spin and between the legs. Significant differences were found between the attack preparation versus the throwing phase for all player time-motion variables: distance covered, time spent, maximum player velocity and average player velocity. Wing players performed most of the throws (85%) and covered longer distances than centres (1.65 vs 0.31 m). The between the legs and the spin throwing techniques presented greater values for most of the time-motion variables (distance covered, time spent and maximum player velocity) than did the frontal technique in both attack phases. These findings provide important information regarding players' movement patterns during goalball matches that can be used to plan more effective training.

46 CFR 160.031-4 - Equipment for shoulder gun type line-throwing appliance.

Science.gov (United States)

2010-10-01

... 46 Shipping 6 2010-10-01 2010-10-01 false Equipment for shoulder gun type line-throwing appliance... Appliance, Shoulder Gun Type (and Equipment) § 160.031-4 Equipment for shoulder gun type line-throwing... the gun. The line canister shall be secured by clamps or brackets below the barrel of the gun. (c) One...

Characterization of blade throw from a 2.3MW horizontal axis wind turbine upon failure

DEFF Research Database (Denmark)

Sarlak, Hamid; Sørensen, Jens Nørkær

2015-01-01

The present work concerns aerodynamics of thrown objects from a 2.3 MW Horizontal Axis Wind Turbine (HAWT), as a consequence of blade failure. The governing set of ordinary differential equations for the flying objects are derived and numerically solved using a 4th order Runge-Kutta time advancing...... on their size. Thereafter, throw distance picks up exponentially with the tip speed. By comparing the throw distance calculations with and without dynamic stall model being active, it is concluded that dynamic stall does not play a major role in throw distances....

INCIDENCIA DE LOS TIROS LIBRES EN PARTIDOS DE BALONCESTO PROFESIONAL [Incidence of free throws in professional basketball games

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José Vicente García Tormo

2015-04-01

The aim of this study is to describe the incident of the free throw on the final results of the basketball match, and see how other factors may influence the final average of successful free throws, comparing national leagues with European competition. A total of 59,364 free throws have been analyzed, corresponding to 1722 matches from two seasons of the Spanish professional basketball league (ACB and LFB and European league (Euroleague Euroleague and women. Has been made descriptive analysis, an analysis of synchrony and an analysis of the residuals corrected. The results demonstrate the importance of free throws for the final score, especially in male and when is a close match. Likewise, the home court advantage is related to higher efficiency in free throws and win the match.

How to Throw a Bird?

DEFF Research Database (Denmark)

Zakaria, Anne Lassen; Bruun, Charlotte

been left behind in global economic development, it is important to recognise that interventions, such as within tourism, cannot start on a tabula rasa. Hence, in this paper we argue that geographical locations are living systems where different stakeholders, formal and informal institutions......, environment with its wildlife, etc., all interact and influence interventions and outcomes. In metaphorical terms developing locations through tourism is like attempting to make a bird fly in a desired direction: One can never predict completely the direction in which it will fly. On the contrary throwing...

Examining Impulse-Variability Theory and the Speed-Accuracy Trade-Off in Children's Overarm Throwing Performance.

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Molina, Sergio L; Stodden, David F

2018-04-01

This study examined variability in throwing speed and spatial error to test the prediction of an inverted-U function (i.e., impulse-variability [IV] theory) and the speed-accuracy trade-off. Forty-five 9- to 11-year-old children were instructed to throw at a specified percentage of maximum speed (45%, 65%, 85%, and 100%) and hit the wall target. Results indicated no statistically significant differences in variable error across the target conditions (p = .72), failing to support the inverted-U hypothesis. Spatial accuracy results indicated no statistically significant differences with mean radial error (p = .18), centroid radial error (p = .13), and bivariate variable error (p = .08) also failing to support the speed-accuracy trade-off in overarm throwing. As neither throwing performance variability nor accuracy changed across percentages of maximum speed in this sample of children as well as in a previous adult sample, current policy and practices of practitioners may need to be reevaluated.

CAN UPPER EXTREMITY FUNCTIONAL TESTS PREDICT THE SOFTBALL THROW FOR DISTANCE: A PREDICTIVE VALIDITY INVESTIGATION

Science.gov (United States)

Hanney, William J.; Kolber, Morey J.; Davies, George J.; Riemann, Bryan

2011-01-01

Introduction: Understanding the relationships between performance tests and sport activity is important to the rehabilitation specialist. The purpose of this study was two- fold: 1) To identify if relationships exist between tests of upper body strength and power (Single Arm Seated Shot Put, Timed Push-Up, Timed Modified Pull-Up, and The Davies Closed Kinetic Chain Upper Extremity Stability Test, and the softball throw for distance), 2) To determine which variable or group of variables best predicts the performance of a sport specific task (the softball throw for distance). Methods: One hundred eighty subjects (111 females and 69 males, aged 18-45 years) performed the 5 upper extremity tests. The Pearson product moment correlation and a stepwise regression were used to determine whether relationships existed between performance on the tests and which upper extremity test result best explained the performance on the softball throw for distance. Results: There were significant correlations (r=.33 to r=.70, p=0.001) between performance on all of the tests. The modified pull-up test was the best predictor of the performance on the softball throw for distance (r2= 48.7), explaining 48.7% of variation in performance. When weight, height, and age were added to the regression equation the r2 values increased to 64.5, 66.2, and 67.5 respectively. Conclusion: The results of this study indicate that several upper extremity tests demonstrate significant relationships with one another and with the softball throw for distance. The modified pull up test was the best predictor of performance on the softball throw for distance. PMID:21712942

Closed-kinetic chain upper-body training improves throwing performance of NCAA Division I softball players.

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Prokopy, Max P; Ingersoll, Christopher D; Nordenschild, Edwin; Katch, Frank I; Gaesser, Glenn A; Weltman, Arthur

2008-11-01

Closed-kinetic chain resistance training (CKCRT) of the lower body is superior to open-kinetic chain resistance training (OKCRT) to improve performance parameters (e.g., vertical jump), but the effects of upper-body CKCRT on throwing performance remain unknown. This study compared shoulder strength, power, and throwing velocity changes in athletes training the upper body exclusively with either CKCRT (using a system of ropes and slings) or OKCRT. Fourteen female National Collegiate Athletic Association Division I softball player volunteers were blocked and randomly placed into two groups: CKCRT and OKCRT. Blocking ensured the same number of veteran players and rookies in each training group. Training occurred three times weekly for 12 weeks during the team's supervised off-season program. Olympic, lower-body, core training, and upper-body intensity and volume in OKCRT and CKCRT were equalized between groups. Criterion variables pre- and posttraining included throwing velocity, bench press one-repetition maximum (1RM), dynamic single-leg balance, and isokinetic peak torque and power (PWR) (at 180 degrees x s(-1)) for shoulder flexion, extension, internal rotation, and external rotation (ER). The CKCRT group significantly improved throwing velocity by 2.0 mph (3.4%, p performance. Strength coaches can incorporate upper-body CKCRT without sacrificing gains in maximal strength or performance criteria associated with an athletic open-chain movement such as throwing.

Water polo throwing velocity and kinematics: differences between competitive levels in male players.

Science.gov (United States)

Melchiorri, G; Viero, V; Triossi, T; De Sanctis, D; Padua, E; Salvati, A; Galvani, C; Bonifazi, M; Del Bianco, R; Tancredi, V

2015-11-01

In water polo, throwing is one of the most important and frequently used technical skills for the player. There is no scientific literature that provides information about differences in throwing between elite and sub-elite water polo players. The aim of our study was to study differences in throwing velocities and kinematic variables in elite and sub-elite level male water polo players. We considered the variables under standardized conditions during a typical motion, the five-meter shot (penalty). Thirty-four athletes from the Men's First Division Water Polo Championship and forty-two players participating in the National Fourth Division League, took part in the study. Video analysis measures were taken with high-speed digital cameras and the videos were analyzed offline with Dartfish 5.0 Pro. No correlation was found between body mass, height and throwing velocity. Elite players had higher values ​for ball speed (22.8±2.4 m/s for elite team and 18.4±1.7 m/s for sub-elite team; P=0.002) and greater elbow angle (157.5±10.3 degree for elite team versus 146.7±8.9 degree for sub-elite team; P=0.002). In elite team the throwing time was lower (165.6±22.2 and 188.6±23.9 ms, respectively; P=0.05) and the shoulder angle was smaller (115.1±10.3 and 123.8±12.4 degree, respectively; P=0.03) than in sub-elite team. Head height was significantly greater in elite players (elite players 71.1±8.7 cm, sub-elite players 65.6±6.2 cm; P=0.03). Differences in kinematic characteristics between elite and sub-elite players were showed. Differences in elbow and shoulder action must be considered both in training and injury prevention.

Biomechanics of increased spin velocity of flying discs during forehand throws by skilled and unskilled throwers.

Science.gov (United States)

Sasakawa, Kei; Umegaki, Koji; Sakurai, Shinji

2018-04-01

We aimed to assess the relationship between throwing distance and kinematic release parameters of the flying disc in unskilled throwers, and to assess the relationship between kinetic variables acting on flying discs and the change in spin velocity during long forehand throws by skilled and unskilled throwers. Ten skilled and eleven unskilled throwers performed throws at maximum effort. Reflective marker positions on the disc and body were recorded with a 3D motion capture system during the throws to derive kinematic variables of a disc and kinetic variables acting on the disc. The analysis interval was from maximum external shoulder rotation to disc release. Significant correlations were observed between the throwing distance and spin velocity in skilled (r = 0.722, P < 0.05) and unskilled throwers (r = 0.794, P < 0.01), between the change in spin velocity and the angular impulse of moments of force, in unskilled throwers (r = 0.703, P < 0.05), and between the change in spin velocity and the angular impulse of torque among skilled throwers (r = 0.680, P < 0.01). Therefore, a strategy for increasing spin velocity in unskilled throwers could be used to generate a larger torque, similar to that observed in skilled throwers.

Perceptual training effects on anticipation of direct and deceptive 7-m throws in handball.

Science.gov (United States)

Alsharji, Khaled E; Wade, Michael G

2016-01-01

We examined the effectiveness of perceptual training on the performance of handball goalkeepers when anticipating the direction of both direct and deceptive 7-m throws. Skilled goalkeepers were assigned equally to three matched-ability groups based on their pre-test performance: a perceptual training group (n = 14) received video-based perceptual training, a placebo training group (n = 14) received video-based regular training and a control group received no training. Participants in the perceptual training group significantly improved their performance compared to both placebo and control groups; however, anticipation of deceptive throws improved less than for direct throws. The results confirm that although anticipating deception in handball is a challenging task for goalkeepers, task-specific perceptual training can minimise its effect and improve performance.

Modelling the Small Throw Fault Effect on the Stability of a Mining Roadway and Its Verification by In Situ Investigation

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Małkowski Piotr

2017-12-01

Full Text Available The small throw fault zones cause serious problems for mining engineers. The knowledge about the range of fractured zone around the roadway and about roadway’s contour deformations helps a lot with the right support design or its reinforcement. The paper presents the results of numerical analysis of the effect of a small throw fault zone on the convergence of the mining roadway and the extent of the fracturing induced around the roadway. The computations were performed on a dozen physical models featuring various parameters of rock mass and support for the purpose to select the settings that reflects most suitably the behavior of tectonically disturbed and undisturbed rocks around the roadway. Finally, the results of the calculations were verified by comparing them with in situ convergence measurements carried out in the maingate D-2 in the “Borynia-Zofiówka-Jastrzębie” coal mine. Based on the results of measurements it may be concluded that the rock mass displacements around a roadway section within a fault zone during a year were four times in average greater than in the section tectonically unaffected. The results of numerical calculations show that extent of the yielding zone in the roof reaches two times the throw of the fault, in the floor 3 times the throw, and horizontally approx. 1.5 to 1.8 times the width of modelled fault zone. Only a few elasto-plastic models or models with joints between the rock beds can be recommended for predicting the performance of a roadway which is within a fault zone. It is possible, using these models, to design the roadway support of sufficient load bearing capacity at the tectonically disturbed section.

Kinematical Comparison Analysis on the Discus Athletes Throwing Techniques Based on Data Project

Science.gov (United States)

Junming, Li; Jihe, Zhou; Ting, Long

2017-09-01

In the discus final site of throwing event series game of China’s track and field sport in April, 2015, three dimensional camera analytical method which is an application of kinematical data project was used on female discus athletes’ discus throwing technology. And analysis was made for the top four discus throwers’ last exertion action, related kinematics parameter was thus obtained. Analysis results show that: first, Lu Xiaoxin behaves better in body twist tight effect when it is left foot on the ground and in capacity of beyond devices, followed by Su Xinyue and Tan Jian, with Feng Bin relatively weaker; second, our athletes’ discus shots speed is to be upgraded compared with world excellent female discus athletes; third, discus is left slightly earlier, with Tan Jian throwing in a reasonable angle, Feng Bin, Lu Xiaoxin in a larger angle, and Sue Xinyue in a smaller angle. Feng bin has a higher height of release, followed by Lu Xiaoxin and Tan jian.

Accuracy of Skill Performance in the Basketball Free Throw Shooting

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Igawa Shoji

2011-12-01

Full Text Available The purpose of this study were to investigates how timing of shot of skilled player and assess performance accuracy of free throw shooting. Ten college students participated in this study (5 skilled players, and 5 naïve participants aged 18-23 years. They performed free throw shooting at 10 times. Shooting seen was recorded three cameras and analyzed shooting successful rate, off-target distance (the distance between the basketball through point and the center of the goal and shot timing. Shot timing was not significant difference. Shooting successful rate of skilled players was higher than unskilled players. Offtarget distance of skilled players was significant smaller than naive player. Consequently, skilled player is possible to aim at the center of the goal and shooting near the center of goal.

A New Learning Control System for Basketball Free Throws Based on Real Time Video Image Processing and Biofeedback

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R. Sarang

2018-02-01

Full Text Available Shooting free throws plays an important role in basketball. The major problem in performing a correct free throw seems to be inappropriate training. Training is performed offline and it is often not that persistent. The aim of this paper is to consciously modify and control the free throw using biofeedback. Elbow and shoulder dynamics are calculated by an image processing technique equipped with a video image acquisition system. The proposed setup in this paper, named learning control system, is able to quantify and provide feedback of the above parameters in real time as audio signals. Therefore, it yielded to performing a correct learning and conscious control of shooting. Experimental results showed improvements in the free throw shooting style including shot pocket and locked position. The mean values of elbow and shoulder angles were controlled approximately on 89o and 26o, for shot pocket and also these angles were tuned approximately on 180o and 47o respectively for the locked position (closed to the desired pattern of the free throw based on valid FIBA references. Not only the mean values enhanced but also the standard deviations of these angles decreased meaningfully, which shows shooting style convergence and uniformity. Also, in training conditions, the average percentage of making successful free throws increased from about 64% to even 87% after using this setup and in competition conditions the average percentage of successful free throws enhanced about 20%, although using the learning control system may not be the only reason for these outcomes. The proposed system is easy to use, inexpensive, portable and real time applicable.

Throw in the i-Drone

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Bram Entrop

2015-08-01

Full Text Available Although many consider drones to be toys, multiple industries, such as the agriculture and mining industry, already know what advantages professional Unmanned Aerial Vehicles (UAVs can offer. However, many companies in the construction industry do not seem to be familiar yet with the possible advantages of UAVs for their projects. In our 3TU Lighthouse project “Throw in the I-drone” we, the University of Twente, Delft University of Technology, and BeemFlights, would like to make the construction industry aware of the possibilities UAVs have by demonstrating possible usages, by providing a protocol on how to use them and by simplifying the interpretation of data collected.

KEEFEKTIFAN PEMBELAJARAN SNOWBALL THROWING BERBANTUAN LEMBAR KEGIATAN SISWA

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Gallant Alim Purbowo

2012-06-01

Full Text Available Abstract Tujuan penelitian ini adalah untuk mengetahui keefektifan pembelajaran Snowball Throwing berbantuan LKS terhadap hasil belajar siswa kelas VIII SMP Negeri 1 Kaliori pada materi lingkaran tahun ajaran 2011/2012. Populasi dalam penelitian ini adalah semua siswa kelas VIII SMP Negeri 1 Kaliori tahun ajaran 2011/2012. Sampel dalam penelitian ini diambil secara cluster random sampling. Data hasil penelitian diperoleh dengan metode tes yang dianalisis dengan menggunakan uji proporsi, uji rata-rata, uji kesamaan dua proporsi, dan uji perbedaan dua rata-rata untuk menguji hipotesis. Hasil penelitian menunjukkan: (1 zhitung =0,5>-(z(0,5-? =-1,64, artinya siswa yang tuntas terhadap hasil belajar pada kelas eksperimen dapat mencapai persentase ketuntasan minimal siswa, (2 thitung=3,9001 >t(1-? =1,69 artinya rata-rata hasil belajar siswa pada kelas eksperimen dapat mencapai KKM, (3 zhitung=2,335>z(0.5-? =1,64, artinya siswa yang tuntas pada kelas eksperimen lebih besar dari kelas kontrol, (4 thitung=2,0194 ? 1,668, artinya rata-rata hasil belajar siswa pada kelas eksperimen lebih dari kelas kontrol. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa penerapan Pembelajaran Snowball Throwing berbantuan LKS efektif terhadap hasil belajar siswa kelas VIII SMP Negeri 1 Kaliori pada materi lingkaran. The purpose of this study was to determine the effectiveness of Snowball Throwing learning assisted students worksheets to learning outcomes of VIII grade in SMP Negeri 1 Kaliori in circle material of the school year 2011/2012. The population in this study were all students in VIII grade SMP Negeri 1 Kaliori academic year 2011/2012. The sample in this study were drawn by cluster random sampling. Research data obtained with the test method were analyzed using the proportion test, test averages, test the equality of two proportions, and test the average difference in the two hypotheses. The results showed: (1 zcount = 0.5> - z(0,5-? = -1.64, meaning

Bio-mechanical assessment toward throwing and lifting process of i-LOCA (Innovative Lobster Catcher)

Science.gov (United States)

Sudiarno, A.; Dewi, D. S.; Putri, M. A.

2018-04-01

Indonesia is the country rich in marine resource, one of which is lobster. East java, one of Indonesian province, especially in Region of Gresik and Lamogan, has very huge potential of lobster. Current condition shown that lobster catch by the fisherman mostly depend on lucky factor, which the lobster unintentionally trapped in fisherman’s fish net. By using this mechanism, the number of lobster catch cannot be optimum. Previous researches have produced two versions of i-LOCA, Innovative Lobster Catcher, a special tool for catching the lobster. Although produce more lobster catch, second version of i-LOCA still needs to be scrutinized, one of that is bio-mechanical assessment. The second version of i-LOCA still has no tool to ease throwing and lifting it into the sea. This condition cause Musculoskeletal Disorder (MSD) toward the fisherman. This research perform bio-mechanical assessment toward throwing and lifting process in order to suggest improvement for i-LOCA as the third version. Based on body moment calculation, we found that throwing and lifting process of third version of i-LOCA, each was 3 times and 2 times better than second version of i-LOCA. Meanwhile, Rapid Entire Body Assessment (REBA) score of throwing and lifting process for third version of i-LOCA can be reduced by 5 points compared to second version of i-LOCA.

THE LEVEL AND AGE DYNAMICS OF SPORTS ACHIEVEMENTS OF ATHLETES-VETERANS OF THE HAMMER THROW

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Ivanova Natalya Dmitrievna

2013-03-01

Full Text Available The article presents the records of the world and Russian athletes veterans in the hammer throw, starting with the age group 35-39 years and up to age group 100-104 years, and a comparison of the records of veterans subject to an age factor and of the high scores of athletes in the current sports. The aim of the work is to analyze the level and dynamics of the records of the world and Russian athletes, veterans in the hammer throw in each five-year group starting with the age group 35-39 years and up to age group 100-104 years. The novelty of the work consists in comparison of the records of the world and Russia in the hammer throw active athletes and records of veterans with the amendment to the age factor. Analysis of the level and age dynamics of sports achievements of domestic and foreign athletes-throwers older age groups. In the course of the research it is established, that in the throwing hammer, decreasing absolute (without regard to the age factor results, which is largely due to the natural age-related changes in the organism of athletes. Records of the world athletes-veterans compared with the records of active athletes and the transition from each of the five-year group in the following, decline on average in men by 10,0%, among women by 19,3%, in spite of the fact that the weight of the shells in the hammer throw with age decreases. Presented the reasons for the backwardness of Russian athletes older than 35 years of foreign veterans.

Throwing in the Middle and Upper Paleolithic: inferences from an analysis of humeral retroversion.

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Rhodes, Jill A; Churchill, Steven E

2009-01-01

When in evolutionary history did long-range projectile weapons become an important component of hunting toolkits? The archeological evidence for the development of projectile weaponry is complex and generally indirect, and has led to different conclusions about the origin and spread of this technology. Lithic evidence from the Middle Stone Age (MSA) has led some researchers to suggest that true long- range projectile weaponry developed in Africa perhaps as early as 80,000 years ago, and was part of the subsistence toolkit carried by modern humans who expanded out of Africa after 50,000 years ago. Alternatively, temporal patterns in the morphology of pointed lithics has led others to posit an independent, convergent origin of projectile weaponry in Africa, the Near East, and Europe during the interval between 50,000-40,000 years ago. By either scenario, projectile weapons would not have been a component of the hunting arsenal of Neandertals, but may have been in use by European early modern humans and thus, projectile technology may have entered into the competitive dynamics that existed between these two groups. The origins of projectile weapons can be addressed, in part, through analyses of the skeletal remains of the prehistoric humans who made and used them. Habitual behavior patterns--including those related to the production and use of technology--can be imprinted on the skeleton through both genetic and epigenetic pathways. Recent studies in the field of sports medicine indicate that individuals who engage in habitual throwing have increased humeral retroversion angles in their throwing arms and a greater degree of bilateral asymmetry in retroversion angles than do non-throwers. This contribution investigates humeral torsion through analysis of the retroversion angle in samples of Eurasian Neandertals, European early modern humans of the middle and late Upper Paleolithic, and comparative samples of recent humans. This analysis was conducted under the

Throwing-related injuries of the subscapularis in professional baseball players

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Polster, Joshua M.; Ilaslan, Hakan; Subhas, Naveen [Cleveland Clinic, Imaging Institute, Cleveland, OH (United States); Lynch, T.S. [Columbia University Medical Center, Center for Shoulder, Elbow and Sports Medicine, New York, NY (United States); Bullen, Jennifer A. [Cleveland Clinic, Quantitative Health Sciences, Cleveland, OH (United States); Soloff, Lonnie [Cleveland Indians, Cleveland, OH (United States); Schickendantz, Mark S. [Cleveland Clinic, Orthopedic and Rheumatologic Institute, Cleveland, OH (United States)

2016-01-15

To describe the MR appearance of a series of throwing-related injuries to the subscapularis muscle-tendon complex among baseball players. A retrospective review of MR scans of the shoulder in players from 1 professional baseball organization over the course of 5 years was performed to identify cases with findings suggestive of subscapularis injury. These findings were graded and the medical record was reviewed to assess clinical findings, treatment, and follow-up. Preinjury baseline measurements of arm external rotation at 90 of abduction were compared to measurements from a noninjured cohort to evaluate whether this measure is a risk factor for injury. A total of 133 MR scans of the shoulder were evaluated. Eleven of the scans demonstrated signal changes suggesting subscapularis injury; 10 of these 11 patients had clinical findings supporting a diagnosis of throwing-related subscapularis strain. There were four grade 1, four grade 2, and two grade 3 injuries. All injuries occurred in the inferior half of the subscapularis at the myotendinous junction. Risk of subscapularis injury increased with lower levels of dominant arm external rotation (odds ratio, 1.12; 95 % CI, 1.07-1.21; p < 0.001). A threshold of dominant arm external rotation of <106 demonstrated sensitivity of 0.700 (95 % CI, 0.392-0.897) and specificity of 0.951 (95 % CI, 0.888-0.982) for subscapularis injury. Throwing-related subscapularis injuries occur in the inferior half of the muscle at the myotendinous junction. Our data suggest that there is an increased risk of these injuries with lower levels of dominant arm external rotation. (orig.)

Age and gender differences in adolescent and adult overarm throwing.

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Lorson, Kevin M; Stodden, David F; Langendorfer, Stephen J; Goodway, Jacqueline D

2013-06-01

The purposes of this study were to examine age and gender differences in throwing performance across an underexplored portion of the lifespan: middle adolescents (14-17 years old), young adults (18-25 years old), and adults (35-55 years old). Throwing performance was assessed using the body component levels from Roberton's developmental sequences for force and ball velocity that were recorded by a radar gun. Participants in each age group performed between 5 to 10 forceful overhand throws toward a target approximately 15m to 20m from the thrower. A Wilcoxon-Mann-Whitney Test was used to determine gender differences and a Wilcoxon-Signed Ranks Test was used to determine age-group differences for each component. Gender and age-group differences in ball speed were determined by a 3 (age group) x 2 (gender) factorial analysis of variance with follow-up post-hoc tests. Young-adult men had higher body component levels and ball speed compared with the adolescent boys and adult men. Female age-group differences existed only for humerus action between young-adult and adult groups and for ball speed between young-adult and adolescent groups. Gender differences (p < .01) existed in component levels for the adolescent and young-adult groups, but not the adult groups. Gender differences in ball speed (p < .001) existed within each age group. Although these data were cross-sectional, the regressive developmental changes observed and the narrowing gender gap may eventually provide insight related to the relationships among motor skill competence, physical fitness, and physical activity across the lifespan.

Throwing-related injuries of the subscapularis in professional baseball players

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Polster, Joshua M.; Ilaslan, Hakan; Subhas, Naveen; Lynch, T.S.; Bullen, Jennifer A.; Soloff, Lonnie; Schickendantz, Mark S.

2016-01-01

To describe the MR appearance of a series of throwing-related injuries to the subscapularis muscle-tendon complex among baseball players. A retrospective review of MR scans of the shoulder in players from 1 professional baseball organization over the course of 5 years was performed to identify cases with findings suggestive of subscapularis injury. These findings were graded and the medical record was reviewed to assess clinical findings, treatment, and follow-up. Preinjury baseline measurements of arm external rotation at 90 of abduction were compared to measurements from a noninjured cohort to evaluate whether this measure is a risk factor for injury. A total of 133 MR scans of the shoulder were evaluated. Eleven of the scans demonstrated signal changes suggesting subscapularis injury; 10 of these 11 patients had clinical findings supporting a diagnosis of throwing-related subscapularis strain. There were four grade 1, four grade 2, and two grade 3 injuries. All injuries occurred in the inferior half of the subscapularis at the myotendinous junction. Risk of subscapularis injury increased with lower levels of dominant arm external rotation (odds ratio, 1.12; 95 % CI, 1.07-1.21; p < 0.001). A threshold of dominant arm external rotation of <106 demonstrated sensitivity of 0.700 (95 % CI, 0.392-0.897) and specificity of 0.951 (95 % CI, 0.888-0.982) for subscapularis injury. Throwing-related subscapularis injuries occur in the inferior half of the muscle at the myotendinous junction. Our data suggest that there is an increased risk of these injuries with lower levels of dominant arm external rotation. (orig.)

Increasing Free Throw Accuracy through Behavior Modeling and Goal Setting.

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Erffmeyer, Elizabeth S.

A two-year behavior-modeling training program focusing on attention processes, retention processes, motor reproduction, and motivation processes was implemented to increase the accuracy of free throw shooting for a varsity intercollegiate women's basketball team. The training included specific learning keys, progressive relaxation, mental…

The relationship between gluteal muscle activation and throwing kinematics in baseball and softball catchers.

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Plummer, Hillary A; Oliver, Gretchen D

2014-01-01

The purpose of this study was to determine the relationship between gluteal muscle activation and pelvis and trunk kinematics when catchers throw to second base. Forty-two baseball and softball catchers (14.74 ± 4.07 years; 161.85 ± 15.24 cm; 63.38 ± 19.98 kg) participated in this study. Muscle activity of the bilateral gluteus maximus and medius as well as pelvis and trunk kinematics throughout the throwing motion were analyzed. It was discovered that at foot contact, there were 2 significant inverse relationships between stride leg gluteus maximus activity and pelvis axial rotation (r = -0.31, r2 = 0.10, p = 0.05), and between trunk axial rotation and pelvis lateral flexion (r = -0.34, r2= 0.12, p = 0.03). In addition, at foot contact, a significant positive relationship between the drive leg (throwing arm side) and trunk flexion (r = 0.33, r2 = 0.11, p = 0.04) was present. The results of this study provide evidence of gluteal activation both concentrically and eccentrically, in attempt to control the pelvis and trunk during the throwing motion of catchers. The gluteal muscles play a direct role in maintaining the stability of the pelvis, and catchers should incorporate strengthening of the entire lumbopelvic-hip complex into their training regimen. Incorporating concentric and eccentric gluteal exercises will help to improve musculoskeletal core stability, thereby assisting in upper extremity injury prevention.

Effects of Variable Resistance Using Chains on Bench Throw Performance in Trained Rugby Players.

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Godwin, Mark S; Fernandes, John F T; Twist, Craig

2018-04-01

Godwin, MS, Fernandes, JFT, and Twist, C. Effects of variable resistance using chains on bench throw performance in trained rugby players. J Strength Cond Res 32(4): 950-954, 2018-This study sought to determine the effects of variable resistance using chain resistance on bench throw performance. Eight male rugby union players (19.4 ± 2.3 years, 88.8 ± 6.0 kg, 1RM 105.6 ± 17.0 kg) were recruited from a national league team. In a randomized crossover design, participant's performed 3 bench throws at 45% one repetition maximum (1RM) at a constant load (no chains) or a variable load (30% 1RM constant load and 15% 1RM variable load; chains) with 7 days between conditions. For each repetition, the peak and mean velocity, peak power, peak acceleration, and time to peak velocity were recorded. Differences in peak and mean power were very likely trivial and unclear between the chain and no chain conditions, respectively. Possibly greater peak and likely greater mean bar velocity were accompanied by likely to most likely greater bar velocity between 50 and 400 ms from initiation of bench press in the chain condition compared with the no chain condition. Accordingly, bar acceleration was very likely greater in the chain condition compared with the no chain condition. In conclusion, these results show that the inclusion of chain resistance can acutely enhance several variables in the bench press throw and gives support to this type of training.

Judgement bias in predicting the success of one’s own basketball free throws but not those of others

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Canal Bruland, R.; Balch, L.; Niesert, L.

2015-01-01

Skilled basketball players are supposed to hit more often from the free throw distance than would be predicted by their shooting performances at adjacent distances. This is dubbed an especial skill. In the current study, we examined whether especial skills in free throw performance in basketball map

Associations between rate of force development metrics and throwing velocity in elite team handball players: a short research report.

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Marques, Mário C; Saavedra, Francisco J; Abrantes, Catarina; Aidar, Felipe J

2011-09-01

Performance assessment has become an invaluable component of monitoring participant's development in distinct sports, yet limited and contradictory data are available in trained subjects. The purpose of this study was to examine the relationship between ball throwing velocity during a 3-step running throw in elite team handball players and selected measures of rate of force development like force, power, velocity, and bar displacement during a concentric only bench press exercise in elite male handball players. Fitteen elite senior male team handball players volunteered to participate. Each volunteer had power and bar velocity measured during a concentric only bench press test with 25, 35, and 45 kg as well as having one-repetition maximum strength determined. Ball throwing velocity was evaluated with a standard 3-step running throw using a radar gun. The results of this study indicated significant associations between ball velocity and time at maximum rate of force development (0, 66; pvelocity was only median associated with maximum rate of force development with light loads. A training regimen designed to improve ball-throwing velocity in elite male team handball players should emphasize bench press movement using light loads.

Plastic forming simulation analysis of marine engine crankshaft single-throw

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LIU Peipei

2016-08-01

Full Text Available The research object is for marine engine crankshaft single-throw.A 3D model of the crankshaft single-throw blank and die in forging process is established by SolidWorks software,then the 3D model is imported into metal plastic forming CAE software DEFROM-3D to carry on the plastic forming simulation,to verify the relationship between the internal flow stress and the external deformation conditions in the process of metal plastic deformation under different strain rate and temperature,and to carry on the scientific analysis based on the obtained data.The result shows that the preset temperature is higher,the stress-strain curve is relatively lower when the strain rate is constant.Sample internal flow stress will be greater and the resistance to fatigue strength will be poorer at a higher strain rate when the temperature of the blank is constant.The result also provides a theoretical basis for further optimization design.

Quantitative assessment of developmental levels in overarm throwing using wearable inertial sensing technology.

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Grimpampi, Eleni; Masci, Ilaria; Pesce, Caterina; Vannozzi, Giuseppe

2016-09-01

Motor proficiency in childhood has been recently recognised as a public health determinant, having a potential impact on the physical activity level and possible sedentary behaviour of the child later in life. Among fundamental motor skills, ballistic skills assessment based on in-field quantitative observations is progressively needed in the motor development community. The aim of this study was to propose an in-field quantitative approach to identify different developmental levels in overarm throwing. Fifty-eight children aged 5-10 years performed an overarm throwing task while wearing three inertial sensors located at the wrist, trunk and pelvis level and were then categorised using a developmental sequence of overarm throwing. A set of biomechanical parameters were defined and analysed using multivariate statistics to evaluate whether they can be used as developmental indicators. Trunk and pelvis angular velocities and time durations before the ball release showed increasing/decreasing trends with increasing developmental level. Significant differences between developmental level pairs were observed for selected biomechanical parameters. The results support the suitability and feasibility of objective developmental measures in ecological learning contexts, suggesting their potential supportiveness to motor learning experiences in educational and youth sports training settings.

Ulnohumeral chondral and ligamentous overload: biomechanical correlation for posteromedial chondromalacia of the elbow in throwing athletes.

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Osbahr, Daryl C; Dines, Joshua S; Breazeale, Nathan M; Deng, Xiang-Hua; Altchek, David W

2010-12-01

Previous studies have documented increased posteromedial contact forces with the elbow at lower flexion angles associated with valgus extension overload; however, the authors believe that posteromedial elbow impingement in association with valgus laxity is a complex pathological process that may occur throughout the entire throwing motion in the form of ulnohumeral chondral and ligamentous overload. Valgus laxity with the elbow at 90° of flexion may lead to chondromalacia secondary to a subtle shift in the contact point between the tip of the olecranon and the distal humeral trochlea. Controlled laboratory study. Six fresh human cadaveric elbows were dissected and subjected to a static valgus load. Pressure-sensitive Fuji film measured the contact pressure, contact area, and shift in contact area across the posteromedial elbow before and after sectioning the anterior bundle of the ulnar collateral ligament. The contact pressure between the tip of the olecranon process and the medial crista of the posterior humeral trochlea significantly increased, from an average of 0.27 ± 0.06 kg/cm² to 0.40 ± 0.08 kg/cm². The contact area also significantly decreased, from an average of 30.34 ± 9.17 mm² to 24.59 ± 6.44 mm², and shifted medially on the medial humeral crista, which corresponds to the position of the posteromedial chondral lesions that was observed in throwing athletes in the authors' clinical practice. While simulating the early acceleration phase of the throwing motion with the elbow in 90° of flexion, the results illustrate that abnormal contact may occur as a result of valgus laxity through increased contact pressures across the posteromedial elbow between the medial tip of the olecranon and medial crista of the humeral trochlea. In addition, congruency of the ulnohumeral joint changed, as there was a statistically significant medial shift of the olecranon on the posterior humeral trochlea with the elbow at 90° of flexion after sectioning the anterior

Effects of 4-Week Training Intervention with Unknown Loads on Power Output Performance and Throwing Velocity in Junior Team Handball Players.

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Rafael Sabido

Full Text Available To compare the effect of 4-week unknown vs known loads strength training intervention on power output performance and throwing velocity in junior team handball players.Twenty-eight junior team-handball players (17.2 ± 0.6 years, 1.79 ± 0.07 m, 75.6 ± 9.4 kgwere divided into two groups (unknown loads: UL; known loads: KL. Both groups performed two sessions weekly consisting of four sets of six repetitions of the bench press throw exercise, using the 30%, 50% and 70% of subjects' individual 1 repetition maximum (1RM. In each set, two repetitions with each load were performed, but the order of the loads was randomised. In the KL group, researchers told the subjects the load to mobilise prior each repetition, while in the UL group, researchers did not provide any information. Maximal dynamic strength (1RM bench press, power output (with 30, 50 and 70% of 1RM and throwing velocity (7 m standing throw and 9 m jumping throw were assessed pre- and post-training intervention.Both UL and KL group improved similarly their 1RM bench press as well as mean and peak power with all loads. There were significant improvements in power developed in all the early time intervals measured (150 ms with the three loads (30, 50, 70% 1RM in the UL group, while KL only improved with 30% 1RM (all the time intervals and with 70% 1RM (at certain time intervals. Only the UL group improved throwing velocity in both standing (4.7% and jumping (5.3% throw (p > 0.05.The use of unknown loads has led to greater gains in power output in the early time intervals as well as to increases in throwing velocity compared with known loads. Therefore unknown loads are of significant practical use to increase both strength and in-field performance in a short period of training.

Effects of 4-Week Training Intervention with Unknown Loads on Power Output Performance and Throwing Velocity in Junior Team Handball Players.

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Sabido, Rafael; Hernández-Davó, Jose Luis; Botella, Javier; Moya, Manuel

2016-01-01

To compare the effect of 4-week unknown vs known loads strength training intervention on power output performance and throwing velocity in junior team handball players. Twenty-eight junior team-handball players (17.2 ± 0.6 years, 1.79 ± 0.07 m, 75.6 ± 9.4 kg)were divided into two groups (unknown loads: UL; known loads: KL). Both groups performed two sessions weekly consisting of four sets of six repetitions of the bench press throw exercise, using the 30%, 50% and 70% of subjects' individual 1 repetition maximum (1RM). In each set, two repetitions with each load were performed, but the order of the loads was randomised. In the KL group, researchers told the subjects the load to mobilise prior each repetition, while in the UL group, researchers did not provide any information. Maximal dynamic strength (1RM bench press), power output (with 30, 50 and 70% of 1RM) and throwing velocity (7 m standing throw and 9 m jumping throw) were assessed pre- and post-training intervention. Both UL and KL group improved similarly their 1RM bench press as well as mean and peak power with all loads. There were significant improvements in power developed in all the early time intervals measured (150 ms) with the three loads (30, 50, 70% 1RM) in the UL group, while KL only improved with 30% 1RM (all the time intervals) and with 70% 1RM (at certain time intervals). Only the UL group improved throwing velocity in both standing (4.7%) and jumping (5.3%) throw (p > 0.05). The use of unknown loads has led to greater gains in power output in the early time intervals as well as to increases in throwing velocity compared with known loads. Therefore unknown loads are of significant practical use to increase both strength and in-field performance in a short period of training.

Comparison of three types of full‐body compression garments on throwing and repeat‐sprint performance in cricket players

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Duffield, Rob; Portus, Marc

2007-01-01

Objective To compare the effects of three types of full‐body compression garments (Skins, Adidas and Under Armour) on repeat‐sprint and throwing performance in cricket players. Methods Following familiarisation, 10 male cricket players performed four randomised exercise sessions (3 garments and a control). Each session involved a 30 min repeat‐sprint exercise protocol comprising 20 m sprints every minute, separated by submaximal exercise. Throwing tests included a pre‐exercise and a postexercise maximal distance test and accuracy throwing tests. During each session, measures of heart rate, skin temperature, change in body mass, rate of perceived exertion and perceived muscle soreness were recorded. Capillary blood samples were analysed before and after exercise for lactate, pH, O2 saturation and O2 partial pressure, and 24 h after exercise for creatine kinase (CK). Ratings of perceived muscle soreness were also obtained 24 h after exercise. Results No significant differences (p>0.05) were evident in repeat‐sprint performance (10 m, 20 m time or total submaximal distance covered) or throwing performance (maximum distance or accuracy). No significant differences (p>0.05) were observed in heart rate, body mass change or blood measures during exercise. Significant differences (p0.05). Conclusions No benefit was noted when wearing compression garments for repeat‐sprint or throwing performance; however, the use of the garments as a recovery tool, when worn after exercise, may be beneficial to reduce postexercise trauma and perceived muscle soreness. PMID:17341589

Comparison of three types of full-body compression garments on throwing and repeat-sprint performance in cricket players.

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Duffield, Rob; Portus, Marc

2007-07-01

To compare the effects of three types of full-body compression garments (Skins, Adidas and Under Armour) on repeat-sprint and throwing performance in cricket players. Following familiarisation, 10 male cricket players performed four randomised exercise sessions (3 garments and a control). Each session involved a 30 min repeat-sprint exercise protocol comprising 20 m sprints every minute, separated by submaximal exercise. Throwing tests included a pre-exercise and a postexercise maximal distance test and accuracy throwing tests. During each session, measures of heart rate, skin temperature, change in body mass, rate of perceived exertion and perceived muscle soreness were recorded. Capillary blood samples were analysed before and after exercise for lactate, pH, O(2) saturation and O(2) partial pressure, and 24 h after exercise for creatine kinase (CK). Ratings of perceived muscle soreness were also obtained 24 h after exercise. No significant differences (p>0.05) were evident in repeat-sprint performance (10 m, 20 m time or total submaximal distance covered) or throwing performance (maximum distance or accuracy). No significant differences (p>0.05) were observed in heart rate, body mass change or blood measures during exercise. Significant differences (p0.05). No benefit was noted when wearing compression garments for repeat-sprint or throwing performance; however, the use of the garments as a recovery tool, when worn after exercise, may be beneficial to reduce postexercise trauma and perceived muscle soreness.

Unknown loads affect force production capacity in early phases of bench press throws.

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Hernández Davó, J L; Sabido Solana, R; Sarabia Marínm, J M; Sánchez Martos, Á; Moya Ramón, M

2015-10-01

Explosive strength training aims to improve force generation in early phases of movement due to its importance in sport performance. The present study examined the influence of lack of knowledge about the load lifted in explosive parameters during bench press throws. Thirteen healthy young men (22.8±2.0 years) participated in the study. Participants performed bench press throws with three different loads (30, 50 and 70% of 1 repetition maximum) in two different conditions (known and unknown loads). In unknown condition, loads were changed within sets in each repetition and participants did not know the load, whereas in known condition the load did not change within sets and participants had knowledge about the load lifted. Results of repeated-measures ANOVA revealed that unknown conditions involves higher power in the first 30, 50, 100 and 150 ms with the three loads, higher values of ratio of force development in those first instants, and differences in time to reach maximal rate of force development with 50 and 70% of 1 repetition maximum. This study showed that unknown conditions elicit higher values of explosive parameters in early phases of bench press throws, thereby this kind of methodology could be considered in explosive strength training.

Plyometric Training Improves Sprinting, Jumping and Throwing Capacities of High Level Female Volleyball Players Better Than Skill-Based Conditioning

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Gjinovci, Bahri; Idrizovic, Kemal; Uljevic, Ognjen; Sekulic, Damir

2017-01-01

There is an evident lack of studies on the effectiveness of plyometric- and skill-based-conditioning in volleyball. This study aimed to evaluate effects of 12-week plyometric- and volleyball-skill-based training on specific conditioning abilities in female volleyball players. The sample included 41 high-level female volleyball players (21.8 ± 2.1 years of age; 1.76 ± 0.06 cm; 60.8 ± 7.0 kg), who participated in plyometric- (n = 21), or skill-based-conditioning-program (n = 20). Both programs were performed twice per week. Participants were tested on body-height, body-mass (BM), countermovement jump (CMJ), standing broad jump (SBJ), medicine ball throw, (MBT) and 20-m sprint (S20M). All tests were assessed at the study baseline (pre-) and at the end of the 12-week programs (post-testing). Two-way ANOVA for repeated measurements showed significant (pvolleyball players. Future studies should evaluate differential program effects in less experienced and younger players. Key points Plyometric- and skill-based-conditioning resulted in improvements in jumping and throwing capacities, but plyometric training additionally induced positive changes in anthropometrics and sprint-capacity The changes induced by plyometric training were larger in magnitude than those achieved by skill-based conditioning. The higher intensity together with possibility of more accurate adjustment of training load in plyometric training are probably the most important determinant of such differential influence. It is likely that the skill-based conditioning program did not result in changes of higher magnitude because of the players’ familiarity with volleyball-related skills. PMID:29238253

Optical design of ultrashort throw liquid crystal on silicon projection system

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Huang, Jiun-Woei

2017-05-01

An ultrashort throw liquid crystal on silicon (LCoS) projector for home cinema, virtual reality, and automobile heads-up display has been designed and fabricated. To achieve the best performance and highest-quality image, this study aimed to design wide-angle projection optics and optimize the illumination for LCoS. Based on the telecentric lens projection system and optimized Koehler illumination, the optical parameters were calculated. The projector's optical system consisted of a conic aspheric mirror and image optics using either symmetric double Gauss or a large-angle eyepiece to achieve a full projection angle larger than 155 deg. By applying Koehler illumination, image resolution was enhanced and the modulation transfer function of the image in high spatial frequency was increased to form a high-quality illuminated image. The partial coherence analysis verified that the design was capable of 2.5 lps/mm within a 2 m×1.5 m projected image. The throw ratio was less than 0.25 in HD format.

Influence of a sport-specific training background on vertical jumping and throwing performance in young female basketball and volleyball players.

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Battaglia, G; Paoli, A; Bellafiore, M; Bianco, A; Palma, A

2014-10-01

The purpose of this study was to evaluate the influence of 3 years of sport-specific training background (SSTB) on vertical jumping and throwing performance in young female basketball and volleyball players. Thirty-one healthy adolescent girls, of which 11 age-matched control subjects [C], 10 basketballers (BP) and 10 volleyballers (VP) participated to the study. The throwing performance was assessed by seated backward overhead ball throw (SBOMBT) and seated chest pass throw (SCPT) using a 3-kg rubber medicine ball. Instead, the vertical jumping performance was evaluated by squat jump (SJ) and countermovement jump with (CMJ-AS) and without arm swing (CMJ) using Optojump system (Microgate srl, Italy). During SJ and CMJ with and without arm swing VP group showed a higher vertical jump performance than BP and C ones. In particular we showed that VP exhibited a higher flight time and jump height than C (Pbasketball athletes' maximal power compared to age-matched control subjects.

Effectiveness of the attack and the throw of the first four teams in the Men's Handball Games ODESUR 2014

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Andrés González Ramírez

2016-07-01

Full Text Available The aim of this research was to analyse the attack actions effectiveness for the first four teams qualified for male team Handball during South American Games 2014 (ODESUR and to compare them with de main international tournaments (Olympics games, World and European Championships. No previous records of this kind of studies had been found in this particular competition of the Olympics classification round. Patterns of observational methodology were followed. Results showed that in ODESUR games, differences between winners and losers where observed in the number of attack endings with throws and ball loses. No meaningful differences where showed in effectiveness throwing. The effectiveness attack and throwing levels were less than in other elite tournaments

Changes in Muscle Architecture, Explosive Ability, and Track and Field Throwing Performance Throughout a Competitive Season and After a Taper.

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Bazyler, Caleb D; Mizuguchi, Satoshi; Harrison, Alex P; Sato, Kimitake; Kavanaugh, Ashley A; DeWeese, Brad H; Stone, Michael H

2017-10-01

The purpose of this study was to examine the effects of an overreach and taper on measures of muscle architecture, jumping, and throwing performance in Division I collegiate throwers preparing for conference championships. Six collegiate track and field throwers (3 hammer, 2 discus, 1 javelin) trained for 12 weeks using a block-periodization model culminating with a 1-week overreach followed by a 3-week taper (ORT). Session rating of perceived exertion training load (RPETL) and strength training volume-load times bar displacement (VLd) were recorded weekly. Athletes were tested pre-ORT and post-ORT on measures of vastus lateralis architecture, unloaded and loaded squat and countermovement jump performance, underhand and overhead throwing performance, and competition throwing performance. There was a statistical reduction in weight training VLd/session (d = 1.21, p ≤ 0.05) and RPETL/session (d = 0.9, p ≤ 0.05) between the in-season and ORT training phases. Five of 6 athletes improved overhead throw and competition throwing performance after the ORT (d = 0.50, p ≤ 0.05). Vastus lateralis muscle thickness statistically increased after the in-season training phase (d = 0.28, p ≤ 0.05) but did not change after the ORT. Unloaded countermovement jump peak force and relative peak power improved significantly after the ORT (d = 0.59, p ≤ 0.05, d = 0.31, p ≤ 0.05, respectively). These findings demonstrate that an overreaching week followed by a 3-week taper is an effective means of improving explosive ability and throwing performance in collegiate track and field throwers despite the absence of detectable changes in muscle architecture.

performance routines followed by free throw shooting accuracy in secondary basketball players

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Phelps Ashley

2015-12-01

Full Text Available Study aim: The purpose of the current study was to determine whether existing pre-performance routines had an effect on free throw shooting accuracy in high school pupils as compared to shooting without a pre-performance routine.

Differences in physical fitness and throwing velocity among elite and amateur male handball players.

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Gorostiaga, E M; Granados, C; Ibáñez, J; Izquierdo, M

2005-04-01

This study compared physical characteristics (body height, body mass [BM], body fat [BF], and free fatty mass [FFM]), one repetition maximum bench-press (1RM (BP)), jumping explosive strength (VJ), handball throwing velocity, power-load relationship of the leg and arm extensor muscles, 5- and 15-m sprint running time, and running endurance in two handball male teams: elite team, one of the world's leading teams (EM, n = 15) and amateur team, playing in the Spanish National Second Division (AM, n = 15). EM had similar values in body height, BF, VJ, 5- and 15-m sprint running time and running endurance than AM. However, the EM group gave higher values in BM (95.2 +/- 13 kg vs. 82.4 +/- 10 kg, p vs. 72.4 +/- 7 kg, p vs. 83 +/- 10 kg, p vs. 21.8 +/- 1.6 m . s (-1), p vs. 22.9 +/- 1.4 m . s (-1), p individual values of velocity at 30 % of 1RM (BP) and individual values of ball velocity during a standing throw. Significant correlations were observed in EM, but not in AM, between the individual values of velocity during 3-step running throw and the individual values of velocity at 30 % of 1RM (BP) (r = 0.72, p individual values of power at 100 % of body mass during half-squat actions (r = 0.62, p < 0.05). The present results suggest that more muscular and powerful players are at an advantage in handball. The differences observed in free fatty mass could partly explain the differences observed between groups in absolute maximal strength and muscle power. In EM, higher efficiency in handball throwing velocity may be associated with both upper and lower extremity power output capabilities, whereas in AM this relationship may be different. Endurance capacity does not seem to represent a limitation for elite performance in handball.

Predictive Ability of the Medicine Ball Chest Throw and Vertical Jump Tests for Determining Muscular Strength and Power in Adolescents

Science.gov (United States)

Hackett, Daniel A.; Davies, Timothy B.; Ibel, Denis; Cobley, Stephen; Sanders, Ross

2018-01-01

This study examined the predictive ability of the medicine ball chest throw and vertical jump for muscular strength and power in adolescents. One hundred and ninety adolescents participated in this study. Participants performed trials of the medicine ball chest throw and vertical jump, with vertical jump peak power calculated via an estimation…

Stride length: the impact on propulsion and bracing ground reaction force in overhand throwing.

Science.gov (United States)

Ramsey, Dan K; Crotin, Ryan L

2018-03-26

Propulsion and bracing ground reaction force (GRF) in overhand throwing are integral in propagating joint reaction kinetics and ball velocity, yet how stride length effects drive (hind) and stride (lead) leg GRF profiles remain unknown. Using a randomised crossover design, 19 pitchers (15 collegiate and 4 high school) were assigned to throw 2 simulated 80-pitch games at ±25% of their desired stride length. An integrated motion capture system with two force plates and radar gun tracked each throw. Vertical and anterior-posterior GRF was normalised then impulse was derived. Paired t-tests identified whether differences between conditions were significant. Late in single leg support, peak propulsion GRF was statistically greater for the drive leg with increased stride. Stride leg peak vertical GRF in braking occurred before acceleration with longer strides, but near ball release with shorter strides. Greater posterior shear GRF involving both legs demonstrated increased braking with longer strides. Conversely, decreased drive leg propulsion reduced both legs' braking effects with shorter strides. Results suggest an interconnection between normalised stride length and GRF application in propulsion and bracing. This work has shown stride length to be an important kinematic factor affecting the magnitude and timing of external forces acting upon the body.

External Versus Two Different Internal Foci of Attention in Long-Distance Throwing.

Science.gov (United States)

Oki, Yuta; Kokubu, Masahiro; Nakagomi, Shiro

2018-02-01

The present study examined the influence of attentional focus on performance during a long-distance throwing task. Twelve participants executed three maximum-effort, long-distance baseball throwing attempts in three focus conditions: internal focus on wrist flexion (wrist internal focus), internal focus on the separation between pelvis and upper torso orientations (torso internal focus), and external focus on the ball path (external focus). Compared with the external focus and torso internal focus conditions, performance was poorer in the wrist internal focus condition. Performances were not different in the torso internal and external focus conditions. In addition, attentional focus affected the release angle of the ball but not its initial velocity. Our results reveal that the body part targeted for internal focus of attention and the forcefulness of the motor activity can be as important to motor performance as whether the attention is internal or external.

Effects of a shoot training programme with a reduced hoop diameter rim on free-throw performance and kinematics in young basketball players.

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Khlifa, Riadh; Aouadi, Ridha; Shephard, Roy; Chelly, Mohamed Souhaiel; Hermassi, Souhail; Gabbett, Tim J

2013-01-01

The present paper investigated the effects of a shoot training programme with a reduced hoop diameter (0.35 m) rim on kinematics and performance of basketball free-throws. Eighteen young male basketball players were divided into control (CG, n = 9) and experimental (EG, n = 9) groups. Both groups undertook a 10-week training programme comprising two training sessions per week. Under fatigued conditions, each participant shot 150 free-throws in each training session, with the CG using a standard rim, and the EG a smaller rim. All other training was identical between groups. Ball release parameters, player's kinematics and mean of successful free-throws (out of 150 attempts) were determined for each participant, before and after completion of the training programme. Following training, a significant increase (P training with a reduced rim significantly improves free-throw performance in young basketball players.

Motion database of disguised and non-disguised team handball penalty throws by novice and expert performers

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Fabian Helm

2017-12-01

Full Text Available This article describes the motion database for a large sample (n = 2400 of 7-m penalty throws in team handball that includes 1600 disguised throws. Throws were performed by both novice (n = 5 and expert (n = 5 penalty takers. The article reports the methods and materials used to capture the motion data. The database itself is accessible for download via JLU Web Server and provides all raw files in a three-dimensional motion data format (.c3d. Additional information is given on the marker placement of the penalty taker, goalkeeper, and ball together with details on the skill level and/or playing history of the expert group. The database was first used by Helm et al. (2017 [1] to investigate the kinematic patterns of disguised movements. Results of this analysis are reported and discussed in their article “Kinematic patterns underlying disguised movements: Spatial and temporal dissimilarity compared to genuine movement patterns” (doi:10.1016/j.humov.2017.05.010 [1]. Keywords: Motion capture data, Disguise, Expertise

Chondromalacia of the trochlear notch in athletes who throw.

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Robla, J; Hechtman, K S; Uribe, J W; Phillipon, M S

1996-01-01

Six athletes who throw and one shot-putter who underwent elbow arthroscopy were found to have an area of chondromalacia involving the posterolateral aspect of the olecranon. Preoperative symptoms were pain and tenderness to palpation over the lateral edge of the olecranon. On physical examination, range of motion was full or only slightly decreased (chondromalacia has not been previously described and, in our study, occurred in individuals whose elbows were subjected to repetitive valgus stress with lateral compression.

The effects of different focus of attention on throwing skills among ...

African Journals Online (AJOL)

The aim of this study was to examine the effects of external focus (EF) of attention compared to internal focus (IF) of attention instructions on throwing boules in a modified-petanque game among the ASD children. Ten ASD children aged from seven to 10 participated in this study. They were randomly divided into two groups ...

Smith machine counterbalance system affects measures of maximal bench press throw performance.

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Vingren, Jakob L; Buddhadev, Harsh H; Hill, David W

2011-07-01

Equipment with counterbalance weight systems is commonly used for the assessment of performance in explosive resistance exercise movements, but it is not known if such systems affect performance measures. The purpose of this study was to determine the effect of using a counterbalance weight system on measures of smith machine bench press throw performance. Ten men and 14 women (mean ± SD: age, 25 ± 4 years; height, 173 ± 10 cm; weight, 77.7 ± 18.3 kg) completed maximal smith machine bench press throws under 4 different conditions (2 × 2; counterbalance × load): with or without a counterbalance weight system and using 'light' or 'moderate' net barbell loads. Performance variables (peak force, peak velocity, and peak power) were measured using a linear accelerometer attached to the barbell. The counterbalance weight system resulted in significant (p velocity (light: -0.49 ± 0.10 m·s; moderate: -0.33 ± 0.07 m·s), and peak power (light: -220 ± 43 W; moderate: -143 ± 28 W) compared with no counterbalance system for both load conditions. Load condition did not affect absolute or percentage reductions from the counterbalance weight system for any variable. In conclusion, the use of a counterbalance weight system reduces accelerometer-based performance measures for the bench press throw exercise at light and moderate loads. This reduction in measures is likely because of an increase in the external resistance during the movement, which results in a discrepancy between the manually input and the actual value for external load. A counterbalance weight system should not be used when measuring performance in explosive resistance exercises with an accelerometer.

Differences in ball speed and three-dimensional kinematics between male and female handball players during a standing throw with run-up.

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Serrien, Ben; Clijsen, Ron; Blondeel, Jonathan; Goossens, Maggy; Baeyens, Jean-Pierre

2015-01-01

The purpose of this paper was to examine differences in ball release speed and throwing kinematics between male and female team-handball players in a standing throw with run-up. Other research has shown that this throwing type produces the highest ball release speeds and comparing groups with differences in ball release speed can suggest where this difference might come from. If throwing technique differs, perhaps gender-specific coordination- and strength-training guidelines are in order. Measurements of three-dimensional kinematics were performed with a seven-camera VICON motion capture system and subsequent joint angles and angular velocities calculations were executed in Mathcad. Data-analysis with Statistical Parametric Mapping allowed us to examine the entire time-series of every variable without having to reduce the data to certain scalar values such as minima/maxima extracted from the time-series. Statistical Parametric Mapping enabled us to detect several differences in the throwing kinematics (12 out of 20 variables had one or more differences somewhere during the motion). The results indicated two distinct strategies in generating and transferring momentum through the kinematic chain. Male team-handball players showed more activity in the transverse plane (pelvis and trunk rotation and shoulder horizontal abduction) whereas female team-handball players showed more activity in the sagital plane (trunk flexion). Also the arm cocking maneuver was quite different. The observed differences between male and female team handball players in the motions of pelvis, trunk and throwing arm can be important information for coaches to give feedback to athletes. Whether these differences contribute to the observed difference in ball release speed is at the present unclear and more research on the relation with anthropometric profile needs to be done. Kinematic differences might suggest gender-specific training guidelines in team-handball.

Effect of Biodiesel of Spent Cooking Oil Addition at Diesel Fuel to Opacity and Gas Emission Throw Away of CO, CO2 and HC

International Nuclear Information System (INIS)

Setyadji, Moch; Endang Susiantini

2007-01-01

Investigation of biodiesel spent cooking oil addition effect at diesel fuel to opacity and gas emission throw away on various engine rotation speed has been done. The variables observed were fuel specific used i.e. pure diesel fuel, biodiesel mix 5% (B5), mix 10% (B10), mix 15% (B15), mix 20% (B20) and engine rotation speed. Gas emission throw away observed were CO, CO 2 , HC and opacity. Opacity and gas emission throwaway were observed by Opacity Sagem apparatus and gas analyzer. Result of experiment showed that biodiesel addition at diesel fuel was very decreasing opacity and gas emission throw away. The opacity lowest on B20, gas emission throw away lowest of CO on B10, CO 2 on B10 and HC on B20. (author)

Throwing velocity and kinematics in elite male water polo players.

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Melchiorri, G; Padua, E; Padulo, J; D'Ottavio, S; Campagna, S; Bonifazi, M

2011-12-01

Fifty-three members of the Italian Men Water Polo Team were filmed using two synchronized cameras, while they were shooting a goal. Considering the differences in body mass, height, training strategies and the technical-tactical features of the players, the aims of this study were to employ video-analysis techniques in order to investigate selected kinematic parameters in water polo throwing, and to provide comprehensive quantitative information on the throwing movement in relation to the different team player positions. Video analysis was used to estimate the elbow angle at release, the shoulder angle at follow through, the back and head height at ball release, trunk rotation angle and ball velocity at release. Ball release velocities ranged from 21.0 to 29.8 m/s (average value 25.3±1.4 m/s), for field players. Goal keepers show the lowest team values (average 21.7±0.3 m/s). Similar to previous study results, ball release was typically reached just prior to the elbow approaching full extension (151.6±3.6°), and the follow through shoulder angle was 143±5.9°. No significant statistical difference was recorded between injured and non-injured athletes. No positive association was demonstrated between physical characteristics (body mass and height) and ball velocity.

Training Physical Education Students to Self-Regulate during Basketball Free Throw Practice

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Cleary, Timothy J.; Zimmerman, Barry J.; Keating, Tedd

2006-01-01

The additive effects of self-regulation training in forethought, performance, and self-reflection phase processes on acquiring a novel motoric skill (i.e., basketball free throws) and self-reflective beliefs were studied with 50 college students. The results showed a positive linear trend between the number of self-regulatory phases, in which the…

Meningkatkan Prestasi Belajar Siswa Kelas VIII.F SMP Negeri 33 Surabaya Pada Mata Pelajaran IPS Materi Pranata Sosial Dengan Model Pembelajaran Snowball Throwing

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Mudjianingsih Mudjianingsih

2017-01-01

                      Asks activities in social studies is an important part in carrying out the study, which asks activities serve to gather information from students, to confirm what was already known, and to bring attention to the aspect of the unknown. Based on observations in the classroom conditions VIII F SMP Negeri 33 Surabaya Surabaya are less enthusiastic in asking questions the need for action using the appropriate learning models, one model of learning that can improve student learning outcomes is learning models Snowball Throwing. In this research there are four research purposes, the fourth such purposes include: 1 To determine the application of learning models Snowball Throwing, 2 To determine activity students 3 To determine student learning outcomes, and 3 To know the constraints and solutions in applying learning models Snowball Throwing.                     This study was a classroom action research (PTK with a qualitative approach in the classroom VIII F SMP Negeri 33 Surabaya Surabaya, which amounted to 32 students. In the application of Snowball Throwing consisting of two cycles, each cycle consisting of the planning stage, the stage of action, observation and reflection stages. Data collection techniques interest asked in this study using observation sheet interest to ask, and for student learning outcomes using the test cycle I and II. Data analysis using data reduction, observation data, and drawing conclusions. The results of this study show that: 1 Application of Learning Model Throwing Snowball carried out with 2 cycles, with each cycle consisting of the planning phase, the implementation phase, observation and reflection phase, 2 Complete test results of students in the first cycle was 68.42% , to test cycle II completeness increased to 100%, completeness criteria in this second cycle in the category Very Good, 3 constraints experienced researchers, among others: the seriousness of the students

Learning Method and Its Influence on Nutrition Study Results Throwing the Ball

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Samsudin; Nugraha, Bayu

2015-01-01

This study aimed to know the difference between playing and learning methods of exploratory learning methods to learning outcomes throwing the ball. In addition, this study also aimed to determine the effect of nutritional status of these two learning methods mentioned above. This research was conducted at SDN Cipinang Besar Selatan 16 Pagi East…

CONNECTION OF FUNCTIONAL ABILITIES WITH JUMPING AND THROWING ATHLETIC DISCIPLINES

OpenAIRE

Igor Stanojević; Dejan Milenković

2014-01-01

The aim of this study was to determine the connection between functional abilities with results of jumping and throwing athletic disciplines with athletes. The sample was taken from a population of elementary school students from Prokuplje region, 13 and 14 old, included in regular physical education classes. The sample consisted of 200 male athletes involved in the training process in sports clubs at least three times a week in addition to physical education classes. For assessment of functi...

High explosive characterization for the dice throw event

Energy Technology Data Exchange (ETDEWEB)

Helm, F.; Finger, M.; Hayes, B.; Lee, E.; Cheung, H.; Walton, J.

1976-06-16

An equation of state for detonation products was developed to describe the detonation of large charges of ammonium nitrate/fuel oil (ANFO). The equation of state will be used to predict air-blast and ground-motion effects in the Dice Throw Event. The explosive performance of ANFO is highly dependent on charge size. The equation developed from this work is applicable to heavily confined detonations 101.6 mm in diameter or larger. The equation of state is based on results from experiments in cylinders and hemispheres, and a large field test. The report contains a detailed discussion of the diagnostic and initiation techniques used in these experiments.

Impulsive force on the head during performance of typical ukemi techniques following different judo throws.

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Hashimoto, Toshihiko; Ishii, Takanori; Okada, Naoyuki; Itoh, Masahiro

2015-01-01

In this study, eight judo athletes who are major candidates for the Japan national team were recruited as participants. Kinematic analysis of exemplary ukemi techniques was carried out using two throws, o-soto-gari, a throw linked to frequent injury, and o-uchi-gari. The aim of this study was to kinematically quantify the timing patterns of exemplary ukemi techniques and to obtain kinematic information of the head, in a sequence of ukemi from the onset of the throw to the completion of ukemi. The results indicated that the vertical velocity with which the uke's head decelerated was reduced by increasing the body surface exposed to the collision with the tatami and by increasing the elapsed time. In particular, overall upper limb contact with the tatami is greatly associated with deceleration. In o-soto-gari, the impulsive force on the faller's head as the head reached the lowest point was 204.82 ± 19.95 kg m · s(-2) while in o-uchi-gari it was 118.46 ± 63.62 kg m · s(-2), z = -1.75, P = 0.08, and it did present a large-sized effect with r = 0.78. These findings indicate that the exemplary o-soto-gari as compared to o-uchi-gari is the technique that causes more significant damage to the uke's head.

Acute influence of the application of strength treatment based on the combinated contrast training method on precision and velocity in overarm handball throwing

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Juan S. Gómez Navarrete

2011-01-01

Full Text Available Abstract Combination of strengh training methods has been shown as an effective way for strengh development. This is specially indicated for improving explosive strengh and power. Our study shows the influence of combined contrast improvement method on overarm throwing in handball. Treatment consisted on one session of combined contras method. 10 handball palyers and 13 non-players participated in this estudy. The instrumental was a gun radar to know velocity throws, a camera to digitalize the accuracy, and an isometric dynamometer for strenght data collection. Results show a significant decrease in peak of force values in players group. Another significant decrease was obsesrved on integral to peak force for both groups. There are significant positive relations between throwing velocity parameters related to weight and size with isometric peak of force. We concluded that isometric time/strengh curve is an usefull instrument to observe changes produced in the subjet's capacity of producing strengh during training. Keywords: Precision, velocity, overarm handball throwing, isometric test, combined contrast method

Rest Interval Required for Power Training With Power Load in the Bench Press Throw Exercise.

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Hernández Davó, Jose L; Solana, Rafael Sabido; Sarabia Marín, Jose M; Fernández Fernández, Jaime; Moya Ramón, Manuel

2016-05-01

This study aimed to test the influence of various rest interval (RI) durations used between sets on power output performance and physiological and perceptual variables during a strength training session using 40% of the 1 repetition maximum (1RM) in the bench press throw exercise. Thirty-one college students (18 males and 13 females) took part in the study. The experimental protocol consists of 5 sets of 8 repetitions of the bench press throw exercise with a load representing 40% of 1RM. Subjects performed the experimental protocol on 3 different occasions, differing by the RI between sets (1, 2, or 3 minutes). During the sessions, power data (mean power and peak power), physiological (lactate concentration [La]) and perceptual (rating of perceived exertion) variables were measured. In addition, delayed onset muscular soreness was reported 24 and 48 hours after the training session. One-way repeated-measures analysis of variance showed that 1-minute RI entailed higher power decreases and greater increases in values of physiological and perceptual variables compared with both 2- and 3-minute RIs. Nevertheless, no differences were found between 2- and 3-minute RIs. Therefore, this study showed that, when training with 40% of 1RM in the bench press throw exercise, a 2-minute RI between sets can be enough to avoid significant decreases in power output. Consequently, training sessions' duration could be reduced without causing excessive fatigue, allowing additional time to focus on other conditioning priorities.

Proceedings of the DICE THROW Symposium 21-23 June 1977. Volume 1

Science.gov (United States)

1977-07-01

Engineering Research Facility. 27. BLAST TESTS OF EXPEDIENT SHELTERS IN THE DICE THROW EVENT- C.H. Kearny, Oak Ridge National Laboratory. 28...Agency, 1977. 10. Gaffney , E., Close-in Measurements of Airblast and Ground Shock, POR 6909, Defense Nuclear Aqency, 1977. 11. Meyer, J., Crater and...EXPEDIENT SHELTERS FIELDED BY THE OAK RIDGE NATIONAL LABORATORY; COMMAND CONTROL COMMUNICATIONS SYSTEMS FIELDED BY THE BALLISTIC RESEARCH LABORATORY AND

Timing and Activation Intensity of Shoulder Muscles during Handball Penalty Throwing in Subjects with and without Shoulder Impingement

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Zahra Zonnor

2017-08-01

Full Text Available Introduction: Shoulder injuries are common among athletes in sports that involve overhead throwing of the ball such as handball. The objectives of this study were to evaluate the timing and activation intensity of shoulder muscles during handball penalty throwing in individuals with shoulder pain and in control subjects. Materials and Methods: Using BTS FREE EMG 300 system with bipolar surface electrodes, the timing (onset and intensity of the activation of the shoulder muscles were measured including upper trapezius, anterior, middle and posterior deltoid, latissimus dorsi, pectoralis major, supraspinatus and triceps during penalty throwing. Multivariate analysis of variance (ANOVA was used for between group comparisons with the significance level P< 0.05. Results: The activation intensity of upper trapezius and latissimus dorsi muscles in the healthy individuals were about 50.74% and 43.42% higher than in patients. Middle deltoid in healthy individuals was about 38.05% smaller than that in patients. In control group, supraspinatus muscle started earlier (23.5 ms than the shoulder motion initiation. Triceps muscle was activated about 18.5 ms later than shoulder motion initiation. In patients, supraspinatus muscle started sooner (11 ms and triceps brachialis muscle started later than the other muscles (22.16 ms. Conclusion: The coordination of shoulder muscles i.e. the onset and intensity of muscle activity is disturbed in the patient group during throwing. Hence, strength and stretching programs are recommended for athletes to reduce the risk of shoulder pain syndrome. The rehabilitation program can be focused on modifying the pattern of activity in upper trapezius, supraspinatus, latissimus dorsi and deltoid muscles in addition to pain control in the rehabilitation centers.

Relationships Between Parents' Child-Rearing Attitudes and the Jumping and Throwing Performance of Their Preschool Children

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Schnabl-Dickey, Elizabeth A.

1977-01-01

Permissive, indulgent home environments (characterized by low disciplinarian, high indulgent, and high protective child-rearing attitudes) were positively associated with superior throwing skill, while increased jumping skill was associated with higher maternal discipline. (MB)

Rotational Acceleration during Head Impact Resulting from Different Judo Throwing Techniques

OpenAIRE

MURAYAMA, Haruo; HITOSUGI, Masahito; MOTOZAWA, Yasuki; OGINO, Masahiro; KOYAMA, Katsuhiro

2014-01-01

Most severe head injuries in judo are reported as acute subdural hematoma. It is thus necessary to examine the rotational acceleration of the head to clarify the mechanism of head injuries. We determined the rotational acceleration of the head when the subject is thrown by judo techniques. One Japanese male judo expert threw an anthropomorphic test device using two throwing techniques, Osoto-gari and Ouchigari. Rotational and translational head accelerations were measured with and without an ...

Interplay between field observations and numerical modeling to understand temporal pulsing of tree root throw processes, Canadian Rockies, Canada

Science.gov (United States)

Martin, Y. E.; Johnson, E. A.; Chaikina, O.

2013-10-01

During the cycle of forest disturbance, regeneration, and maturity, tree mortality leading to topple is a regular occurrence. When tree topple occurs relatively soon after mortality and if the tree has attained some threshold diameter at breast height (dbh) at the time of death, then notable amounts of soil may be upheaved along with the root wad. This upheaval may result in sediment transfers and soil production. A combination of field evidence and numerical modeling is used herein to gain insights regarding the temporal dynamics of tree topple, associated root throw processes, and pit-mound microtopography. Results from our model of tree population dynamics demonstrate temporal patterns in root throw processes in subalpine forests of the Canadian Rockies, a region in which forests are affected largely by wildfire disturbance. As the forest regenerates after disturbance, the new cohort of trees has to reach a critical dbh before significant root plate upheaval can occur; in the subalpine forests of the Canadian Rockies, this may take up to ~ 102 years. Once trees begin to reach this critical dbh for root plate upheaval, a period of sporadic root throw arises that is caused by mortality of trees during competition. In due course, another wildfire will occur on the landscape and a period of much increased root throw activity then takes place for the next several decades; tree sizes and, therefore, the amount of sediment disturbance will be greater the longer the time period since the previous fire. Results of previous root throw studies covering a number of regional settings are used to guide an exercise in diffusion modeling with the aim of defining a range of reasonable diffusion coefficients for pit-mound degradation; the most appropriate values to fit the field data ranged from 0.01 m2 y- 1 to 0.1 m2 y- 1. A similar exercise is then undertaken that is guided by our field observations in subalpine forests of the Canadian Rockies. For these forests, the most

Prediction of shot success for basketball free throws: visual search strategy.

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Uchida, Yusuke; Mizuguchi, Nobuaki; Honda, Masaaki; Kanosue, Kazuyuki

2014-01-01

In ball games, players have to pay close attention to visual information in order to predict the movements of both the opponents and the ball. Previous studies have indicated that players primarily utilise cues concerning the ball and opponents' body motion. The information acquired must be effective for observing players to select the subsequent action. The present study evaluated the effects of changes in the video replay speed on the spatial visual search strategy and ability to predict free throw success. We compared eye movements made while observing a basketball free throw by novices and experienced basketball players. Correct response rates were close to chance (50%) at all video speeds for the novices. The correct response rate of experienced players was significantly above chance (and significantly above that of the novices) at the normal speed, but was not different from chance at both slow and fast speeds. Experienced players gazed more on the lower part of the player's body when viewing a normal speed video than the novices. The players likely detected critical visual information to predict shot success by properly moving their gaze according to the shooter's movements. This pattern did not change when the video speed was decreased, but changed when it was increased. These findings suggest that temporal information is important for predicting action outcomes and that such outcomes are sensitive to video speed.

Strength, Endurance, Throwing Velocity and in-Water Jump Performance of Elite German Water Polo Players

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Zinner Christoph

2015-03-01

Full Text Available The purpose of this study was threefold: 1 to assess the eggbeater kick and throwing performance using a number of water polo specific tests, 2 to explore the relation between the eggbeater kick and throwing performance, and 3 to investigate the relation between the eggbeater kick in the water and strength tests performed in a controlled laboratory setting in elite water polo players. Fifteen male water polo players of the German National Team completed dynamic and isometric strength tests for muscle groups (adductor, abductor, abdominal, pectoralis frequently used during water polo. After these laboratory strength tests, six water polo specific in-water tests were conducted. The eggbeater kick assessed leg endurance and agility, maximal throwing velocity and jump height. A 400 m test and a sprint test examined aerobic and anaerobic performance. The strongest correlation was found between jump height and arm length (p < 0.001, r = 0.89. The laboratory diagnostics of important muscles showed positive correlations with the results of the in-water tests (p < 0.05, r = 0.52-0.70. Muscular strength of the adductor, abdominal and pectoralis muscles was positively related to in-water endurance agility as assessed by the eggbeater kick (p < 0.05; r = 0.53-0.66. Findings from the current study emphasize the need to assess indices of water polo performance both in and out of the water as well as the relation among these parameters to best assess the complex profile of water polo players.

Strength Training Using Elastic Bands: Improvement of Muscle Power and Throwing Performance in Young Female Handball Players.

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Mascarin, Naryana Cristina; de Lira, Claudio Andre Barbosa; Vancini, Rodrigo Luiz; de Castro Pochini, Alberto; da Silva, Antonio Carlos; Dos Santos Andrade, Marilia

2017-05-01

Imbalance in shoulder-rotator muscles has been considered a risk factor for injuries in handball. Strength training programs (STPs) may play an important preventive role. To verify the effects of an STP using elastic bands on shoulder muscles and ball-throwing speed. Randomized and prospective controlled trial. Exercise physiology laboratory. Thirty-nine female handball players were randomly assigned to an experimental (EG, n = 21, 15.3 ± 1.1 y) or a control (CG, n = 18, 15.0 ± 0.8 y) group. The EG performed the STP with elastic-band progressive exercises for 6 wk before regular handball training, and the CG underwent only their regular training. Before and after the STP, both groups underwent a ball-throwing-speed test and isokinetic test to assess shoulder internal- (IR) and external-rotator muscle performance. Average power values for IR muscles presented a significant group-vs-time interaction effect (F = 3.9, P = .05); EG presented significantly higher values after the STP (P = .03). Ball speed presented higher values in EG after the STP in standing (P = .04) and jumping (P = .03) throws. IR peak-torque values and balance in shoulder-rotator muscles presented no group-vs-time interaction effect. STP using elastic bands performed for 6 wk was effective to improve muscle power and ball speed for young female handball players.

THE RELATIONS BETWEEN MORPHOLOGICAL SPACE AND THE ATHLETES’ JUMPING AND THROWING EVENTS RESULT

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Igor Stanojević

2014-12-01

Full Text Available The sample included 200 primary school students in the region of Prokuplje, male, aged 13 and 14 years, who, in addition to regular physical education classes, were included in the sports clubs training activities. The variables sample included 13 anthropometric measures as a set of predictors and four specific-motor tests of jumping (high jump and long jump and throwing events (shot put and javelin, as well as a set of criteria. The aim of this research was to examine the relation of morphological characteristics with the jumping and throwing events results, with elementary school students as athletes. Determining the relations and influence between the morphological characteristics and the specific motor skills was obtained by applying the canonical-correlation and regression analysis. The research of canonical correlation analysis results showed that there are statistically significant interlinks between canonical factors of morphological dimension Can. 0.81% (p = .000 and the results of examinee’s specific-motor skills in a long running jump, running high jump, shot put and javelin. Regression analysis results show that the morphological dimensions have an important prediction of the results of examinee’s specific-motor skills.

Don't throw the bathwater in with the baby.

Science.gov (United States)

Lichtenstein, Paul

2012-01-01

The Presidential Address of the European Association of Developmental Psychology this year concerned how genes and environments interplay to shape loneliness and other developmental psychological relevant outcomes. This is a very welcome. However, when developmental psychology now is ready to integrate recent genetic and neuroscience knowledge and methods, I think it would be very wise to not uncritical go through the mistakes that have be done in other disciplines and instead learn from their hard lessons. I discuss some problems (genes versus environments, identifying gene for a phenotype, environments cause of developmental outcomes, and gene X environment interaction and epigenetics) and some suggestions for solutions which can be used to avoid throwing in the bathwater with the baby.

Rotational acceleration during head impact resulting from different judo throwing techniques.

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Murayama, Haruo; Hitosugi, Masahito; Motozawa, Yasuki; Ogino, Masahiro; Koyama, Katsuhiro

2014-01-01

Most severe head injuries in judo are reported as acute subdural hematoma. It is thus necessary to examine the rotational acceleration of the head to clarify the mechanism of head injuries. We determined the rotational acceleration of the head when the subject is thrown by judo techniques. One Japanese male judo expert threw an anthropomorphic test device using two throwing techniques, Osoto-gari and Ouchi-gari. Rotational and translational head accelerations were measured with and without an under-mat. For Osoto-gari, peak resultant rotational acceleration ranged from 4,284.2 rad/s(2) to 5,525.9 rad/s(2) and peak resultant translational acceleration ranged from 64.3 g to 87.2 g; for Ouchi-gari, the accelerations respectively ranged from 1,708.0 rad/s(2) to 2,104.1 rad/s(2) and from 120.2 g to 149.4 g. The resultant rotational acceleration did not decrease with installation of an under-mat for both Ouchi-gari and Osoto-gari. We found that head contact with the tatami could result in the peak values of translational and rotational accelerations, respectively. In general, because kinematics of the body strongly affects translational and rotational accelerations of the head, both accelerations should be measured to analyze the underlying mechanism of head injury. As a primary preventative measure, throwing techniques should be restricted to participants demonstrating ability in ukemi techniques to avoid head contact with the tatami.

Plyometric Training Improves Sprinting, Jumping and Throwing Capacities of High Level Female Volleyball Players Better Than Skill-Based Conditioning.

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Gjinovci, Bahri; Idrizovic, Kemal; Uljevic, Ognjen; Sekulic, Damir

2017-12-01

There is an evident lack of studies on the effectiveness of plyometric- and skill-based-conditioning in volleyball. This study aimed to evaluate effects of 12-week plyometric- and volleyball-skill-based training on specific conditioning abilities in female volleyball players. The sample included 41 high-level female volleyball players (21.8 ± 2.1 years of age; 1.76 ± 0.06 cm; 60.8 ± 7.0 kg), who participated in plyometric- (n = 21), or skill-based-conditioning-program (n = 20). Both programs were performed twice per week. Participants were tested on body-height, body-mass (BM), countermovement jump (CMJ), standing broad jump (SBJ), medicine ball throw, (MBT) and 20-m sprint (S20M). All tests were assessed at the study baseline (pre-) and at the end of the 12-week programs (post-testing). Two-way ANOVA for repeated measurements showed significant (pPlyometric group significantly reduced body-mass (trivial effect size [ES] differences; 1% average pre- to post-measurement changes), and improved their performance in S20M (moderate ES; 8%), MBT (very large ES; 25%), CMJ (large ES; 27%), and SBJ (moderate ES; 8%). Players involved in skill-based-conditioning significantly improved CMJ (large ES; 18%), SBJ (small ES; 3%), and MBT (large ES; 9%). The changes which occurred between pre- and post-testing were more inter-correlated in plyometric-group. Although both training-modalities induced positive changes in jumping- and throwing-capacities, plyometric-training is found to be more effective than skill-based conditioning in improvement of conditioning capacities of female senior volleyball players. Future studies should evaluate differential program effects in less experienced and younger players.

Treatment of stress fracture of the olecranon in throwing athletes with internal fixation through a small incision

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Fujioka Hiroyuki

2012-12-01

Full Text Available Abstract The present study is a report of retrospective case series of stress fracture of the olecranon. Six patients presented posterior elbow pain in throwing in baseball and softball, but fracture was not diagnosed in radiographs. We detected stress fracture of the olecranon using computed tomographic (CT scan and treated the patient with internal fixation with a headless cannulated double threaded screw through a small skin incision. All patients returned to competitive level without elbow complaints after the operation. When throwing athletes present with unusual posterior elbow pain and no significant findings on radiographs, a CT scan examination should be performed. We recommend surgical treatment of internal fixation with a screw through a small skin incision, as a good option for stress fracture of the olecranon in order to allow early return to sports activity in competitive athletes.

UPAYA MENINGKATKAN MINAT BELAJAR SISWA MELALUI MODEL PEMBELAJARAN KOOPERATIF TIPE SNOWBALL THROWING PADA MATA DIKLAT KOMUNIKASI SISWA SMK

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Dian Pratiwi

2016-02-01

Full Text Available Tujuan penelitian untuk meningkatkan minat belajar siswa melalui model pembelajaran kooperatif tipe Snowball Throwing pada mata diklat komunikasi siswa kelas X AP SMK Gatra Praja Pekalongan. Subjek penelitian ini adalah siswa kelas X AP yang berjumlah 37 siswa. jenis penelitian adalah penelitian tindakan kelas, dilakukan dalam dua siklus. Teknik pengumpulan data menggunakan observasi, kuesioner,dan dokumentasi. Hasil penelitian menunjukkan minat belajar hasil dari lembar pengamatan siklus I sebesar 60,33% dengan kategori kurang berminat dan pada siklus II menjadi 75,27% dengan kategori berminat. Sedangkan hasil minat belajar dari angket/kuesioner pada siklus I 68,90% dengan kategori berminat dan pada siklus II menjadi 76,71% dengan kategori berminat. Kesimpulanya Penerapan pembelajaran menggunakan model Snowball Throwing dapat meningkatkan minat belajar siswa kelas X AP pada mata diklat komunikasi SMK Gatra Praja Pekalongan, terbukti setiap siklusnya mengalami peningkatan. This study is aimed at improving students’ interest through cooperative learning model Snowball Throwing at Communication Training Subject in Class X Office Administration of Gatra Praja Vocational High School Pekalongan. Subject of this research was the 37 students of XI AP. This type of research is classroom action research and conducted in two cycles. Data collecting technique used is observation, questionnaires, and documentation. The result of the research shows that the learning interest form of the observation sheet on the first cycle is 60.33% with less interest category and the second cycle, it turns into 75.27% to the category of interest. While the results of the learning interest from the questionnaire in the first cycle is 68.90% of the maximum percentage of the interest category and the second cycle it turns into 76.71% to the category of interest. The conclusion is the application of learning using models Snowball Throwing can increase students’ interest in

Don’t throw the bathwater in with the baby

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Lichtenstein, Paul

2013-01-01

The Presidential Address of the European Association of Developmental Psychology this year concerned how genes and environments interplay to shape loneliness and other developmental psychological relevant outcomes. This is a very welcome. However, when developmental psychology now is ready to integrate recent genetic and neuroscience knowledge and methods, I think it would be very wise to not uncritical go through the mistakes that have be done in other disciplines and instead learn from their hard lessons. I discuss some problems (genes versus environments, identifying gene for a phenotype, environments cause of developmental outcomes, and gene X environment interaction and epigenetics) and some suggestions for solutions which can be used to avoid throwing in the bathwater with the baby. PMID:23745130

The optical design of ultra-short throw system for panel emitted theater video system

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Huang, Jiun-Woei

2015-07-01

In the past decade, the display format from (HD High Definition) through Full HD(1920X1080) to UHD(4kX2k), mainly guides display industry to two directions: one is liquid crystal display(LCD) from 10 inch to 100 inch and more, and the other is projector. Although LCD has been popularly used in market; however, the investment for production such kind displays cost more money expenditure, and less consideration of environmental pollution and protection[1]. The Projection system may be considered, due to more viewing access, flexible in location, energy saving and environmental protection issues. The topic is to design and fabricate a short throw factor liquid crystal on silicon (LCoS) projection system for cinema. It provides a projection lens system, including a tele-centric lens fitted for emitted LCoS to collimate light to enlarge the field angle. Then, the optical path is guided by a symmetric lens. Light of LCoS may pass through the lens, hit on and reflect through an aspherical mirror, to form a less distortion image on blank wall or screen for home cinema. The throw ratio is less than 0.33.

Understanding and acknowledging the ice throw hazard - consequences for regulatory frameworks, risk perception and risk communication

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Bredesen, R. E.; Drapalik, M.; Butt, B.

2017-11-01

This study attempts to provide the necessary framework required to make sufficiently informed decisions regarding the safety implications of ice throw. The framework elaborates on how to cope with uncertainties, and how to describe results in a meaningful and useful manner to decision makers. Moreover, it points out the moral, judicial and economical obligations of wind turbine owners such that they are able to minimize risk of ice throws as much as possible. Building on the strength of knowledge as well as accounting for uncertainty are also essential in enabling clear communication with stakeholders on the most important/critical/vital issues. With increasing empirical evidence, one can assign a higher confidence level on the expert opinions on safety. Findings regarding key uncertainties of ice risk assessments are presented here to support the ongoing IEA Wind Task 19's work on creating the international guidelines on ice risk assessment due in 2018 (Krenn et al. 2017)[1-6]. In addition the study also incorporates the findings of a Norwegian information project, which focuses on the ice throw hazard for the public (Bredesen, Flage, Butt, Winterwind 2018)[7-9]. This includes measures to reduce damage and hazard from wind turbines for the general public. Recent theory of risk assessment questions the use of risk criteria for achieving optimum risk reduction and favours the use of the ALARA (as low as reasonably achievable) principle. Given the several practical problems associated with the ALARA approach (e.g. judicial realization), a joint approach, which uses a minimum set of criteria as well as the obligation to meet ALARA is suggested (associated with acceptable cost). The actual decision about acceptance criteria or obligations is a societal one, thus suggestions can be made at best. Risk acceptance, risk perception and risk communication are inextricably linked and should thus never be considered separately. Risk communication can shape risk perception

The overarm-throwing pattern among U-14 ASA female softball players: a comparative study of gender, culture, and experience.

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Petranek, Laura Jones; Barton, Gina V

2011-06-01

A developmental description of overarm-throwing characteristics of U-14female ASA softballplayers is presented here. Comparisons were made between these athletes and teens of similar age in the United States (Runion, Roberton, & Langendorfe 2003) and in Germany (Ehl, Roberton, & Langendorfer, 2005). A majority of the softball players demonstrated the most advanced developmental levels for the backswing foot, humerus, and forearm components. Seventy percent (n = 26) demonstrated a Level 2 trunk, while 30% (n = 11) demonstrated a differentiated trunk, Level 3. The average throwing velocity was 62.58 ft/s (19.07 m/s). Comparisons were made to girls with less throwing experience in the United States (Runion et al.) and Germany (Ehl et al.); the softball players threw with greater velocity (9.12ft/s [2.77 m/s]and 15.89 ft/s [4.84 m/s], respectively) and demonstrated superior trunk, humerus, and forearm actions. The boys from both countries threw the ball faster than the softball players. Significant chi-square analyses found the softball players had superior humeral actions (Level 3) compared to the German boys and superior forearm actions (Level 3) compared to both groups of bays. Experience seems to have an impact when comparisons among girls are made; yet, explanations for differences seen between boys and girls still remain unclear and warrant further research.

Ability Beliefs, Task Value, and Performance as a Function of Race in a Dart-Throwing Task

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Gao, Zan; Kosma, Maria; Harrison, Louis, Jr.

2009-01-01

This study examines differences in self-efficacy, expectancy-related beliefs, task value, and performance in a dart-throwing task as a function of race among diverse college students using the expectancy-value model and self-efficacy theory. It also examines the predictive contributions of these beliefs on task performance within each racial…

Plyometric Training Improves Sprinting, Jumping and Throwing Capacities of High Level Female Volleyball Players Better Than Skill-Based Conditioning

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Bahri Gjinovci, Kemal Idrizovic, Ognjen Uljevic, Damir Sekulic

2017-12-01

Full Text Available There is an evident lack of studies on the effectiveness of plyometric- and skill-based-conditioning in volleyball. This study aimed to evaluate effects of 12-week plyometric- and volleyball-skill-based training on specific conditioning abilities in female volleyball players. The sample included 41 high-level female volleyball players (21.8 ± 2.1 years of age; 1.76 ± 0.06 cm; 60.8 ± 7.0 kg, who participated in plyometric- (n = 21, or skill-based-conditioning-program (n = 20. Both programs were performed twice per week. Participants were tested on body-height, body-mass (BM, countermovement jump (CMJ, standing broad jump (SBJ, medicine ball throw, (MBT and 20-m sprint (S20M. All tests were assessed at the study baseline (pre- and at the end of the 12-week programs (post-testing. Two-way ANOVA for repeated measurements showed significant (p<0.05 “Group x Time” effects for all variables but body-height. Plyometric group significantly reduced body-mass (trivial effect size [ES] differences; 1% average pre- to post-measurement changes, and improved their performance in S20M (moderate ES; 8%, MBT (very large ES; 25%, CMJ (large ES; 27%, and SBJ (moderate ES; 8%. Players involved in skill-based-conditioning significantly improved CMJ (large ES; 18%, SBJ (small ES; 3%, and MBT (large ES; 9%. The changes which occurred between pre- and post-testing were more inter-correlated in plyometric-group. Although both training-modalities induced positive changes in jumping- and throwing-capacities, plyometric-training is found to be more effective than skill-based conditioning in improvement of conditioning capacities of female senior volleyball players. Future studies should evaluate differential program effects in less experienced and younger players.

Deliberate utilization of interaction torques brakes elbow extension in a fast throwing motion.

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Hore, Jon; Debicki, Derek B; Gribble, Paul L; Watts, Sherry

2011-05-01

We tested the hypothesis that in fast arm movements the CNS deliberately utilizes interaction torques to decelerate (brake) joint rotations. Twelve subjects performed fast 2-D overarm throws in which large elbow extension velocities occurred. Joint motions were computed from recordings made with search coils; joint torques were calculated using inverse dynamics. After ball release, a large follow-through shoulder extension acceleration occurred that was initiated by shoulder extensor muscle torque. This shoulder acceleration produced a flexor interaction torque at the elbow that initiated elbow deceleration (braking). An instantaneous mechanical interaction of passive torques then occurred between elbow and shoulder, i.e., elbow extension deceleration produced a large shoulder extensor interaction torque that contributed to the shoulder extension acceleration which, simultaneously, produced a large elbow flexor interaction torque that contributed to elbow extension deceleration, and so on. Late elbow flexor muscle torque also contributed to elbow deceleration. The interaction of passive torques between shoulder and elbow was braked by shoulder flexor muscle torque. In this mechanism, shoulder musculature contributed to braking elbow extension in two ways: shoulder extensors initiated the mechanical interaction of passive torques between shoulder and elbow and shoulder flexors dissipated kinetic energy from elbow braking. It is concluded that, in fast 2-D throws, the CNS deliberately utilizes powerful interaction torques between shoulder and elbow to brake motion at the elbow.

NiThrowTM a dedicated tool to D and D applications

International Nuclear Information System (INIS)

Objois, Laurent; Moggia, Fabrice; Damerval, Frederique; Varet, Thierry; Toulemonde, Valerie; Richard, Frederic

2012-09-01

D and D operations of nuclear site facilities, is a long, complicated and important stage. Usually, such operations involve the implementation of a large number of different technologies (mechanicals and/or chemicals) dedicated to cutting and decontamination operations. Such processes proved to work since facilities are being decommissioned. However as larger projects are foreseen, the capability of such applications to fulfil the requirement in term of economics, techniques and environment/social remains uncertain. Indeed, several aspects such as the efficiency, the speed but also the number of operators required to operate and for sure the quantity of generated wastes remain an important key point. In that context, it appears important to develop a new technology capable to be quicker, safer, and friendlier for operators and the environment. In this context, the Clean-Up Business Unit of AREVA group (BE/CL) with its partner Air Liquide worked on the development of a new cryogenic process. Started in 2008, this work was based on the use of highly pressurized liquid nitrogen in order to achieve the three mains D and D operations which are: - Cutting. - Surface decontamination. - Concrete scabbling. In this paper, three parts will be presented. The first one will give a brief overview of this new technology so called NiThrow TM . The second one will exhibit the results obtained during our different tests. And finally, the third part will be focused on the R and D developments we realized in order to fully nuclearized this NiThrow TM technology but also on its tuning in order to qualify it for nuclear environments. (authors)

Designing Pay-As-You-Throw schemes in municipal waste management services: A holistic approach

International Nuclear Information System (INIS)

Elia, Valerio; Gnoni, Maria Grazia; Tornese, Fabiana

2015-01-01

Highlights: • Pay-As-You-Throw (PAYT) schemes are becoming widespread in several countries. • Economic, organizational and technological issues have to be integrated in an efficient PAYT model design. • Efficiency refers to a PAYT system which support high citizen participation rates as well as economic sustainability. • Different steps and constraints have to be evaluated from collection services to type technologies. • An holistic approach is discussed to support PAYT systems diffusion. - Abstract: Pay-As-You-Throw (PAYT) strategies are becoming widely applied in solid waste management systems; the main purpose is to support a more sustainable – from economic, environmental and social points of view – management of waste flows. Adopting PAYT charging models increases the complexity level of the waste management service as new organizational issues have to be evaluated compared to flat charging models. In addition, innovative technological solutions could also be adopted to increase the overall efficiency of the service. Unit pricing, user identification and waste measurement represent the three most important processes to be defined in a PAYT system. The paper proposes a holistic framework to support an effective design and management process. The framework defines most critical processes and effective organizational and technological solutions for supporting waste managers as well as researchers

Designing Pay-As-You-Throw schemes in municipal waste management services: A holistic approach

Energy Technology Data Exchange (ETDEWEB)

Elia, Valerio; Gnoni, Maria Grazia, E-mail: mariagrazia.gnoni@unisalento.it; Tornese, Fabiana

2015-10-15

Highlights: • Pay-As-You-Throw (PAYT) schemes are becoming widespread in several countries. • Economic, organizational and technological issues have to be integrated in an efficient PAYT model design. • Efficiency refers to a PAYT system which support high citizen participation rates as well as economic sustainability. • Different steps and constraints have to be evaluated from collection services to type technologies. • An holistic approach is discussed to support PAYT systems diffusion. - Abstract: Pay-As-You-Throw (PAYT) strategies are becoming widely applied in solid waste management systems; the main purpose is to support a more sustainable – from economic, environmental and social points of view – management of waste flows. Adopting PAYT charging models increases the complexity level of the waste management service as new organizational issues have to be evaluated compared to flat charging models. In addition, innovative technological solutions could also be adopted to increase the overall efficiency of the service. Unit pricing, user identification and waste measurement represent the three most important processes to be defined in a PAYT system. The paper proposes a holistic framework to support an effective design and management process. The framework defines most critical processes and effective organizational and technological solutions for supporting waste managers as well as researchers.

The Relationships between Ball Throwing Velocity and Physical-Psychomotor Features for Talent Identification in Physical Education

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Karadenizli, Zeynep Inci

2016-01-01

The aim of this study is to investigate the relationships between ball throwing velocity (BTV), and physical features and anaerobic power (AP) for talent identification in team handball players. Players (n: 54) at 21,91 ± 4,94 age, training experience 11,19 ± 4,46 years participated voluntarily to study. These players consist of 54 Turkish…

Can we throw information out of visual working memory and does this leave informational residue in long-term memory?

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Ashleigh Monette Maxcey

2014-04-01

Full Text Available Can we entirely erase a temporary memory representation from mind? This question has been addressed in several recent studies that tested the specific hypothesis that a representation can be erased from visual working memory based on a cue that indicated that the representation was no longer necessary for the task. In addition to behavioral results that are consistent with the idea that we can throw information out of visual working memory, recent neurophysiological recordings support this proposal. However, given the infinite capacity of long-term memory, it is unclear whether throwing a representation out of visual working memory really removes its effects on memory entirely. In this paper we advocate for an approach that examines our ability to erase memory representations from working memory, as well as possible traces that those erased representations leave in long-term memory.

STUDI KOMPARATIF MODEL PEMBELAJARAN TALKING STICK DAN SNOWBALL THROWING TERHADAP HASIL BELAJAR TEKNOLOGI INFORMASI DAN KOMUNIKASI (TIK SISWA KELAS XI SMA NEGERI 1 SERIRIT TAHUN AJARAN 2015/2016

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Ni Made Dwi Antari

2016-10-01

Abstract TIK learning must have to prepared student’s activities and creativities to obtained the own knowledge by means of learning process. An appropriate learning model election agree with students characteristics would help an success learning. The comparative study research would have to compared both of learning model, to know which model was better. This research aimed to know (1 The influenced about the result of students’ TIK study used Talking stick and Snowball Throwing learning model (2 the highest result of study between Talking stick and Snowball Throwing learning model (3 the students’ response toward Talking stick and Snowball Throwing learning model application. Kind of this research was quasi experiment by Post Test Only with Non Equivalent Control Group Design. The data accumulation done by multiple choice tests to measured cognitive domain and skill test to psychomotor domain. The students’ result study analyzed by prerequisite test was normality test and homogeneity by the result of the three group which normal distribution and homogeneous, continued by hypothesis test used a strip Anova then continued by t-Sheffe The result of one way onova exist a significance influenced on the used of Talking Stick leaarning model, Snowball Throwing and conventional. Because of thee was a significance difereences between each partner. Afterwards, seen from the result average of study  can be concluded the Talking Stick learning model better than the higest result average of study. Meanwhile, the respond of used questionnaire method, the result of Talking stick model questionnaire known 36% very positive responses, 61% positive responses and 3% positive sufficient responses. Then, Snowball Throwing model known 25% very positive responses, 67% positive responses, and 8% positive sufficient responses.   Keywords : The Comparrative Study, TIK, Talking stick, Snowball Throwing, the                    study result,  students’ respond

The effect of low extremity plyometric training on back muscle power of high school throwing event athletes.

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Park, Gi Duck; Lee, Joong Chul; Lee, Juri

2014-01-01

[Purpose] The physical strength elements required for athletic throwing events include muscle strength, swiftness, agility, speed, flexibility, and physical balance. Although plyometric training and weight training are implemented as representative training methods for improving swiftness and agility, most studies of it have been conducted with players of other sports. [Subjects] The study subjects were 10 throwing event athletes attending K physical education high school. The subjects were randomly assigned to a control group of five subjects and an experimental group of five subjects. To analyze the body composition, an Inbody 3.0 instrument (Biospace, Korea) was used as experimental equipment to measure heights, weight, body fat percentages, and muscle masses and a Biodex system 4.0 (BIODEX, USA) was used to measure isokinetic muscle-joint and lumbar muscle strengths. The plyometric training consisted of 15 techniques out of the training methods introduced in the 'Power up plyometric training'. The plyometric program was implemented without any training load three times per week during daybreak exercises for the experimental group. The number of times and the number of sets were changed over time as follows: three sets of 10 times in the 1st -4th weeks, three sets of 15 times in the 5th-8th weeks, and five sets of 15 times in the 9th-12th weeks. [Results] According to the ANCOVA results of lumbar extensor muscle strength at 60°/sec, the overall reliability of the model was significant. According to the ANCOVA results of lumbar flexor muscle strength at 60°/sec, the overall reliability of the model was significant. [Conclusion] Plyometric training positively affected high school throwing event athletes. To summarize the study findings, the application of plyometric training with high intensity and loads improved the results of athletes who perform highly intensive exercises at normal times.

DIFERENCIAS EN LA CAPACIDAD DE LANZAMIENTO EN FUNCIÓN DE LA ETAPA DEPORTIVA EN JUGADORES DE BALONMANO [Differences in the throwing capacity according to the phases of sporting life in handball players

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Jesús Rivilla-Garcia

2010-09-01

Full Text Available ResumenEl presente estudio pretendió analizar la capacidad de lanzamiento general y específica en función de las etapas de vida deportiva. Con dicho objetivo, ciento seis jugadores de balonmano de diferentes edades y niveles competitivos fueron evaluados en cuatro pruebas de lanzamiento de progresiva especificidad: 1 lanzamiento de balón medicinal pesado (LBMP, 2 lanzamiento de balón medicinal ligero (LBML, 3 velocidad de lanzamiento sin oposición (VSO y 4 velocidad de lanzamiento con oposición (VCO.Los jugadores fueron divididos según su edad (Seiru-lo, 1998: 1ª etapa (16-19 años, 2ª etapa (20-23 años, 3ª etapa (24-28 años y 4ª etapa (más de 29 años. El análisis de diferencias de medias de lanzamiento determinó diferencias significativas entre las cuatro etapas de vida deportiva en los cuatro test de lanzamiento, LBMP (F 3, 102 =34,15; p3, 102=34,76; p 3, 102=55,89; p 3, 102=29,89; pPara todos los grupos la velocidad de lanzamiento fue menor con oposición que sin ella, pero solo se observaron diferencias significativas en la 1ª etapa (20,15±2,34 m·s-1 y 21,41 ±1,70 m·s-1, VCO y VSO, respectivamente; p-1 y 25,92 ±1,67 m·s-1, VCO y VSO, respectivamente; p=0,033; t=2,293; gl=18.En conclusión, la etapa de vida deportiva parece determinante en la evolución de la capacidad de lanzamiento, sobre todo en los test específicos. Igualmente, la oposición del portero parece influir negativamente en la velocidad de lanzamiento, fundamentalmente entre las edades de 16-19 años y 24-28 años.Palabras clave: lanzamiento con balón medicinal, velocidad de lanzamiento, edad, oposición.AbstractThis study aimed to test the general and specific throwing capacity based on the sporting life stages. For that purpose, one hundred and six players of handball of different age and competitive levels were evaluated in four throwing test of progressive specificity: 1 throw with heavy medicine ball (LBMP, 2 throw with light medicine ball (LBML

Full cost accounting as a tool for the financial assessment of Pay-As-You-Throw schemes: a case study for the Panorama municipality, Greece.

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Karagiannidis, Avraam; Xirogiannopoulou, Anna; Tchobanoglous, George

2008-12-01

In the present paper, implementation scenarios of a Pay-As-You-Throw program were developed and analyzed for the first time in Greece. Firstly, the necessary steps for implementing a Pay-As-You-Throw program were determined. A database was developed for the needs of the full cost accounting method, where all financial and waste-production data were inserted, in order to calculate the unit price of charging for four different implementation scenarios of the "polluter-pays" principle. For each scenario, the input in waste management cost was estimated, as well as the total waste charges for households. Finally, a comparative analysis of the results was performed.

The Influence of Task Constraints on the Glenohumeral Horizontal Abduction Angle of the Overarm Throw of Novice Throwers

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Breslin, Casey M.; Garner, John C.; Rudisill, Mary E.; Parish, Loraine E.; St. Onge, Paul M.; Campbell, Brian J.; Weimar, Wendi H.

2009-01-01

This study determines the effects of three baseballs and softballs of different masses (0.113 kg, 0.198 kg, 0.340 kg) and regulation diameters (22.86 and 30.48 cm, respectively) on the glenohumeral horizontal abduction angle of an overarm throw performed by young children who were novice throwers. Glenohumeral horizontal abduction angle was…

Food Ration and Mental Training for the Improvement of the Free Throw Performance in Congolese Beginners Basketball Players

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Bouhika, Eddie Janvier; Moussouami, Simplice Innocent; Tsiama Portejoie, Jean Aimé; Bazaba Kayilou, Jean Michel; Moyen, Rachel; Mizere Moungondo, Martin; Maouene, Michel; Mbemba, François

2016-01-01

Objective: Through an experimental study, the present work aims at testing the effectiveness of diet and mental imagery on the success of free throw in Congolese beginners Basketball Players. Method: 45 players participated in this experimental study in Brazzaville (Congo). These subjects were divided into 3 groups. Group I (n = 15), made up of…

The Overarm-Throwing Pattern among U-14 ASA Female Softball Players: A Comparative Study of Gender, Culture, and Experience

Science.gov (United States)

Petranek, Laura Jones; Barton, Gina V.

2011-01-01

A developmental description of overarm-throwing characteristics of U-14 female ASA softball players is presented here. Comparisons were made between these athletes and teens of similar age in the United States (Runion, Roberton, & Langendorfer, 2003) and in Germany (Ehl, Roberton, & Langendorfer, 2005). A majority of the softball players…

The Throw-and-Catch Model of Human Gait: Evidence from Coupling of Pre-Step Postural Activity and Step Location

Science.gov (United States)

Bancroft, Matthew J.; Day, Brian L.

2016-01-01

Postural activity normally precedes the lift of a foot from the ground when taking a step, but its function is unclear. The throw-and-catch hypothesis of human gait proposes that the pre-step activity is organized to generate momentum for the body to fall ballistically along a specific trajectory during the step. The trajectory is appropriate for the stepping foot to land at its intended location while at the same time being optimally placed to catch the body and regain balance. The hypothesis therefore predicts a strong coupling between the pre-step activity and step location. Here we examine this coupling when stepping to visually-presented targets at different locations. Ten healthy, young subjects were instructed to step as accurately as possible onto targets placed in five locations that required either different step directions or different step lengths. In 75% of trials, the target location remained constant throughout the step. In the remaining 25% of trials, the intended step location was changed by making the target jump to a new location 96 ms ± 43 ms after initiation of the pre-step activity, long before foot lift. As predicted by the throw-and-catch hypothesis, when the target location remained constant, the pre-step activity led to body momentum at foot lift that was coupled to the intended step location. When the target location jumped, the pre-step activity was adjusted (median latency 223 ms) and prolonged (on average by 69 ms), which altered the body’s momentum at foot lift according to where the target had moved. We conclude that whenever possible the coupling between the pre-step activity and the step location is maintained. This provides further support for the throw-and-catch hypothesis of human gait. PMID:28066208

The Throw-and-Catch Model of Human Gait: Evidence from Coupling of Pre-Step Postural Activity and Step Location.

Science.gov (United States)

Bancroft, Matthew J; Day, Brian L

2016-01-01

Postural activity normally precedes the lift of a foot from the ground when taking a step, but its function is unclear. The throw-and-catch hypothesis of human gait proposes that the pre-step activity is organized to generate momentum for the body to fall ballistically along a specific trajectory during the step. The trajectory is appropriate for the stepping foot to land at its intended location while at the same time being optimally placed to catch the body and regain balance. The hypothesis therefore predicts a strong coupling between the pre-step activity and step location. Here we examine this coupling when stepping to visually-presented targets at different locations. Ten healthy, young subjects were instructed to step as accurately as possible onto targets placed in five locations that required either different step directions or different step lengths. In 75% of trials, the target location remained constant throughout the step. In the remaining 25% of trials, the intended step location was changed by making the target jump to a new location 96 ms ± 43 ms after initiation of the pre-step activity, long before foot lift. As predicted by the throw-and-catch hypothesis, when the target location remained constant, the pre-step activity led to body momentum at foot lift that was coupled to the intended step location. When the target location jumped, the pre-step activity was adjusted (median latency 223 ms) and prolonged (on average by 69 ms), which altered the body's momentum at foot lift according to where the target had moved. We conclude that whenever possible the coupling between the pre-step activity and the step location is maintained. This provides further support for the throw-and-catch hypothesis of human gait.

Peningkatan Hasil Belajar Siswa Materi Usaha Mempertahankan Republik Indonesia Melalui Model Pembelajaran Snowball Throwing Pada Kelas IX.2 SMP Negeri Muara Beliti

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Holili Holili

2017-10-01

Full Text Available This study aims to improve student learning outcomes of class IX.2 State Junior High School Muara Beliti on the material business to defend the Republic of Indonesia by using the Snowball throwing learning. The research method used is Classroom Action Research. The study was conducted in two cycles with each model cycle following the procedure: planning, action, observation, and reflection. The action of two cycles resulted in improving the quality of learning and improving the learning outcomes, the average completeness of students' learning cycle one 68.55% completeness 61.29%. Cycle two averages 80.1% completeness 90%. The end result of the two cycle action succeeded in improving the IPS learning outcomes. Keywords: Learning Outcome, Snowball throwing   http://dx.doi.org/10.17977/um022v2i12017p025

Diferencias en la distancia de lanzamiento y velocidad de balón según el puesto específico en jugadores de balonmano sub-18. (Differences in the throwing distance and ball velocity by playing position in under-18 handball players.

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Javier Sampedro Molinuelo

2011-01-01

Full Text Available ResumenEl presente estudio ha analizado las diferencias entre puestos específicos ofensivos en la distancia delanzamiento con balón medicinal pesado y liviano y en la velocidad de lanzamiento con y sin oposición en jugadores en formación. Para ello, cincuenta y ocho jugadores realizaron pruebas de progresiva especificidad: lanzamiento con balón medicinal pesado (LBMP y ligero (LBML, velocidad de lanzamiento sin (VL y con oposición (VLO.VLO fue menor a VL en todos los puestos específicos, con diferencias significativas en los jugadores laterales (p AbstractThis study aims to analyze the differences in throwing distance with overweight ball and throwing velocity without and with opposition according to the playing positions in trainees handball players. For this purpose, fifty-eight players were assessed in four specific progress throwing situations: throwing with heavy medicinal ball (THMB and light medicinal ball (TLMB, throwing velocity without (TV and with opposition (TVO.TVO was less than TV in all playing positions, with significant differences in back (p doi:10.5232/ricyde2011.02202

Numerical simulation of the throwing power of cathodic prevention applied to marine reinforced concrete piles by means of sacrificial anodes

Energy Technology Data Exchange (ETDEWEB)

Bertolini, Luca; Redaelli, Elena [Politecnico di Milano, Dipartimento di Chimica, Materiali e Ingegneria Chimica ' G. Natta' , Via Mancinelli, 7, 20131 Milan (Italy)

2004-07-01

The paper deals with the determination of current and potential distribution in reinforced concrete elements partially submerged in seawater aimed at predicting the throwing power of cathodic prevention applied by means of sacrificial anodes. Previous laboratory studies carried out on reinforced concrete columns 15 cm x 15 cm x 120 cm showed that the use of sacrificial anodes placed in the solution at the bottom of the column could provide protection of corroding steel bars in the emerged part of the pile up to about 60 cm from the water level. However, if sacrificial anodes were applied when the concrete was chloride free and steel bars were still passive, even the highest bar, placed at 1 m from the level of water, was protected. This is due to the higher polarizability of passive steel, that makes the throwing power of cathodic prevention higher compared to that of cathodic protection. In order to extend the results obtained on small-scale specimens to elements of higher dimensions, numerical simulations of current and potential distribution were carried out. Two-dimensional models were set up of reinforced concrete piles containing steel bars at different heights protected with sacrificial anodes placed in the water in which they were partially submerged. Boundary conditions describing the electrochemical behaviour of bars were obtained from polarisation curves measured on the previously mentioned columns. Values of concrete conductivity at different heights from the water level were also obtained from those tests. Several cases were considered, representative of conditions differing in electrochemical behaviour of steel bars, dimensions of element, position of sacrificial anodes. The paper discusses the results obtained from the models and compares them in terms of the throwing power that can be reached by using sacrificial anodes immersed in the seawater to protect reinforcing steel bars in the emerged part of a pile. (authors)

Assist-as-needed robotic trainer based on reinforcement learning and its application to dart-throwing.

Science.gov (United States)

Obayashi, Chihiro; Tamei, Tomoya; Shibata, Tomohiro

2014-05-01

This paper proposes a novel robotic trainer for motor skill learning. It is user-adaptive inspired by the assist-as-needed principle well known in the field of physical therapy. Most previous studies in the field of the robotic assistance of motor skill learning have used predetermined desired trajectories, and it has not been examined intensively whether these trajectories were optimal for each user. Furthermore, the guidance hypothesis states that humans tend to rely too much on external assistive feedback, resulting in interference with the internal feedback necessary for motor skill learning. A few studies have proposed a system that adjusts its assistive strength according to the user's performance in order to prevent the user from relying too much on the robotic assistance. There are, however, problems in these studies, in that a physical model of the user's motor system is required, which is inherently difficult to construct. In this paper, we propose a framework for a robotic trainer that is user-adaptive and that neither requires a specific desired trajectory nor a physical model of the user's motor system, and we achieve this using model-free reinforcement learning. We chose dart-throwing as an example motor-learning task as it is one of the simplest throwing tasks, and its performance can easily be and quantitatively measured. Training experiments with novices, aiming at maximizing the score with the darts and minimizing the physical robotic assistance, demonstrate the feasibility and plausibility of the proposed framework. Copyright © 2014 Elsevier Ltd. All rights reserved.

Arremessar por cima do ombro e a distância percorrida pelo implemento Overarm throw and the distance traveled by the implement

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Samuel Bento da Silva

2009-12-01

Full Text Available A habilidade de arremessar por cima do ombro tem sido bastante estudada, observando-se a velocidade do implemento, porém enquanto muitas tarefas têm como objetivo arremessar o mais longe possível, a distância percorrida pelo objeto ainda não tem sido investigada. O objetivo deste estudo foi verificar se existe relação entre o estágio de desenvolvimento motor nesta habilidade e a distância percorrida pelo implemento e observar diferenças entre os gêneros masculino e feminino; 50 crianças, com idade entre 7-8 anos, de ambos os gêneros, procedentes de Piracicaba - SP foram analisadas enquanto arremessavam uma bola de tênis de campo, o mais longe possível. Cada criança realizou três arremessos intercalados e foi filmada com duas câmeras mini DV, tanto em vista lateral quanto posterior, enquanto arremessava. O nível de desenvolvimento das crianças foi classificado, utilizando-se uma sequência de desenvolvimento e a distância percorrida pela bola foi registrada. Foi encontrada correlação significativa entre o nível do desenvolvimento e a distância atingida. Diferenças entre os gêneros foram observadas: os meninos encontravam-se em níveis desenvolvimentais mais avançados em todas as ações e alcançaram maiores distâncias. Assim, o nível de desenvolvimento desta habilidade mostrou-se importante para o alcance de seu objetivo (arremessar mais longe. Sugere-se que o nível de habilidade é influenciado pelo meio ambiente e que oportunidades de movimento devem ser providenciadas para auxiliar o desenvolvimento integral da criança.Overarm throwing skill has been widely studied regarding the farthest throwing distance analysing the velocity of the implement; however the object's distance has not been investigated. The aim of this study was to verify if there is a relationship between the skill development and the distance reached by the object and to observe differences between genders. Fifty children, ages 7-8 years, both

Blast tests of expedient shelters in the DICE THROW event

International Nuclear Information System (INIS)

Kearny, C.H.; Chester, C.V.

1978-03-01

To determine the worst blast environments that eight types of expedient shelters can withstand, we subjected a total of 18 shelters to the 1-kiloton blast effects of Defense Nuclear Agency's DICE THROW main event. These expedient shelters included two Russian and two Chinese types. The best shelter tested was a Small-Pole Shelter that had a box-like room of Russian design with ORNL-designed expedient blast entries and blast doors added. It was undamaged at the 53-psi peak overpressure range; the pressure rise inside was only 1.5 psi. An unmodified Russian Pole-Covered Trench Shelter was badly damaged at 6.8 psi. A Chinese ''Man'' Shelter, which skillfully uses very small poles to attain protective earth arching, survived 20 psi, undamaged. Two types of expedient shelters built of materials found in and around most American homes gave good protection at overpressures up to about 6 psi. Rug-Covered Trench Shelters were proved unsatisfactory. Water storage pits lined with ordinary plastic trash bags were proven practical at up to 53 psi, as were triangular expedient blast doors made of poles

Strength Determinants of Jump Height in the Jump Throw Movement in Women Handball Players.

Science.gov (United States)

McGhie, David; Østerås, Sindre; Ettema, Gertjan; Paulsen, Gøran; Sandbakk, Øyvind

2018-06-08

McGhie, D, Østerås, S, Ettema, G, Paulsen, G, and Sandbakk, Ø. Strength determinants of jump height in the jump throw movement in women handball players. J Strength Cond Res XX(X): 000-000, 2018-The purpose of the study was to improve the understanding of the strength demands of a handball-specific jump through examining the associations between jump height in a jump throw jump (JTJ) and measures of lower-body maximum strength and impulse in handball players. For comparison, whether the associations between jump height and strength differed between the JTJ and the customarily used countermovement jump (CMJ) was also examined. Twenty women handball players from a Norwegian top division club participated in the study. Jump height was measured in the JTJ and in unilateral and bilateral CMJ. Lower-body strength (maximum isometric force, one-repetition maximum [1RM], impulse at ∼60% and ∼35% 1RM) was measured in seated leg press. The associations between jump height and strength were assessed with correlation analyses and t-tests of dependent r's were performed to determine if correlations differed between jump tests. Only impulse at ∼35% 1RM correlated significantly with JTJ height (p jump height and strength were significantly weaker in the JTJ than in both CMJ tests for all strength measures (p = 0.001-0.044) except one. Maximum strength and impulse at ∼60% 1RM did not seem to sufficiently capture the capabilities associated with JTJ height, highlighting the importance of employing tests targeting performance-relevant neuromuscular characteristics when assessing jump-related strength in handball players. Further, CMJ height seemed to represent a wider range of strength capabilities and care should be taken when using it as a proxy for handball-specific movements.

Establishing Substantial Equivalence: Transcriptomics

Science.gov (United States)

Baudo, María Marcela; Powers, Stephen J.; Mitchell, Rowan A. C.; Shewry, Peter R.

Regulatory authorities in Western Europe require transgenic crops to be substantially equivalent to conventionally bred forms if they are to be approved for commercial production. One way to establish substantial equivalence is to compare the transcript profiles of developing grain and other tissues of transgenic and conventionally bred lines, in order to identify any unintended effects of the transformation process. We present detailed protocols for transcriptomic comparisons of developing wheat grain and leaf material, and illustrate their use by reference to our own studies of lines transformed to express additional gluten protein genes controlled by their own endosperm-specific promoters. The results show that the transgenes present in these lines (which included those encoding marker genes) did not have any significant unpredicted effects on the expression of endogenous genes and that the transgenic plants were therefore substantially equivalent to the corresponding parental lines.

Substantial Union or Substantial Distinction of Mind and Body in Descartes' Metaphysics

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Fahime Jamei

2009-01-01

Full Text Available According to Descartes’ metaphysics there are two different kinds of substances in the world of creatures: “thinking substance” and “extended substance” or soul and matter. In Descartes’ philosophy the soul is equal to the mind and considered as a “thinking substance”. This immaterial substance is the essence of the human being. Body, being considered as a “matter“, is an “extended substance” and entirely distinct from the soul. The soul, therefore, exists and may be known prior to body and, not being corporeal, can exist after human death. Hence, Descartes can prove the immortality of human soul in the framework of the principle of substantial distinction. On the other hand, as a physiologist and psychologist, Descartes indeed believes in mind-body union, so that some causal interactions between mind and body show their substantial union. In this essay, the authors show that Descartes faces a serious problem in combining substantial union of mind and body with their substantial distinction; despite of his efforts in introducing the idea of pineal gland, the problem remains unsolved. Therefore it seems that as he cannot dispense with his only reason for proving the immortality of human soul, he has to hold the mind-body distinction theory in his metaphysics. Indeed, Descartes prefers to support the distinction theory rather than union theory in confronting a thesis and an antithesis stating one of two theories

Substantial :union: or Substantial Distinction of Mind and Body in Descartes\\' Metaphysics

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f Jamei

2009-06-01

Full Text Available According to Descartes’ metaphysics there are two different kinds of substances in the world of creatures: “thinking substance” and “extended substance” or soul and matter. In Descartes’ philosophy the soul is equal to the mind and considered as a “thinking substance”. This immaterial substance is the essence of the human being. Body, being considered as a “matter“, is an “extended substance” and entirely distinct from the soul. The soul, therefore, exists and may be known prior to body and, not being corporeal, can exist after human death. Hence, Descartes can prove the immortality of human soul in the framework of the principle of substantial distinction. On the other hand, as a physiologist and psychologist, Descartes indeed believes in mind-body :union:, so that some causal interactions between mind and body show their substantial :union:. In this essay, the authors show that Descartes faces a serious problem in combining substantial :union: of mind and body with their substantial distinction despite of his efforts in introducing the idea of pineal gland, the problem remains unsolved. Therefore it seems that as he cannot dispense with his only reason for proving the immortality of human soul, he has to hold the mind-body distinction theory in his metaphysics. Indeed, Descartes prefers to support the distinction theory rather than :union: theory in confronting a thesis and an antithesis stating one of two theories.

24 CFR 902.79 - Substantial default.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Substantial default. 902.79 Section... PUBLIC HOUSING ASSESSMENT SYSTEM PHAS Incentives and Remedies § 902.79 Substantial default. (a) Events or conditions that constitute substantial default. The following events or conditions shall constitute...

Stresses in the plantar region for long- and short-range throws in women basketball players.

Science.gov (United States)

Pau, Massimiliano; Ciuti, Carla

2013-01-01

This study aimed to assess plantar pressure pattern modifications caused by short- and long-distance shots in women basketball players. To this end, 24 experienced national- and regional-level basketball players performed 3 trials of 4 technical gestures (free throw, jump stop shot, three-point shot and lay-up) barefoot on a pressure platform placed in fixed positions on the court. Raw data were processed to calculate location and magnitude of pressure peaks in three sub-regions (forefoot, midfoot and rearfoot), and the increase ratio was calculated relative to plantar pressure measured during a static bipedal and unipedal upright stance. The results showed significant increases (ptraining and rehabilitation protocols.

Effects of Relaxing and Arousing Music during Imagery Training on Dart-Throwing Performance, Physiological Arousal Indices, and Competitive State Anxiety.

Science.gov (United States)

Kuan, Garry; Morris, Tony; Kueh, Yee Cheng; Terry, Peter C

2018-01-01

Music that is carefully selected to match the requirements of activities and the characteristics of individuals has been shown to produce significant impacts on performance enhancement (Priest et al., 2004). There is also evidence that music can enhance imagery (Grocke and Wigram, 2007), although few studies have investigated the effects of music on imagery in the context of sport skills. In the present study, the effects of relaxing and arousing music during imagery on dart-throwing performance, physiological arousal indices, and competitive state anxiety, were investigated among 63 novice dart throwers. Participants had moderate-to-high imagery ability and were randomly assigned to unfamiliar relaxing music (URM), unfamiliar arousing music (UAM), or no music (NM) groups. Performance was assessed by 40 dart throws at a concentric circles dartboard before and after 12 imagery sessions over 4 weeks. Measures of galvanic skin response (GSR), peripheral temperature (PT), and heart rate (HR) were taken during imagery sessions 1 and 12, and the Competitive State Anxiety Inventory-2 Revised (CSAI-2R) was administered prior to the pre- and post-intervention performance task. Dart-throwing gain scores were significantly higher for URM than for UAM and NM, with no significant difference between UAM and NM (URM = 37.24 ± 5.66, UAM = 17.57 ± 5.30, and NM = 13.19 ± 6.14, F 2,62 = 5.03, p = 0.01, η 2 = 0.14). GSR, PT, and HR reflected lower arousal for URM than for UAM or NM. Significant decreases in somatic anxiety were evident for URM and UAM but not NM. Significant decreases in cognitive anxiety were evident for URM and NM but not UAM. Significant increases in self-confidence were evident for URM but not UAM or NM. Performance improved in all three conditions but URM was associated with the largest performance gain, the lowest physiological indices of arousal, and the most positive CSAI-2R profiles. Listening to relaxing music during imagery may have benefits for

Effects of Relaxing and Arousing Music during Imagery Training on Dart-Throwing Performance, Physiological Arousal Indices, and Competitive State Anxiety

Directory of Open Access Journals (Sweden)

Garry Kuan

2018-02-01

Full Text Available Music that is carefully selected to match the requirements of activities and the characteristics of individuals has been shown to produce significant impacts on performance enhancement (Priest et al., 2004. There is also evidence that music can enhance imagery (Grocke and Wigram, 2007, although few studies have investigated the effects of music on imagery in the context of sport skills. In the present study, the effects of relaxing and arousing music during imagery on dart-throwing performance, physiological arousal indices, and competitive state anxiety, were investigated among 63 novice dart throwers. Participants had moderate-to-high imagery ability and were randomly assigned to unfamiliar relaxing music (URM, unfamiliar arousing music (UAM, or no music (NM groups. Performance was assessed by 40 dart throws at a concentric circles dartboard before and after 12 imagery sessions over 4 weeks. Measures of galvanic skin response (GSR, peripheral temperature (PT, and heart rate (HR were taken during imagery sessions 1 and 12, and the Competitive State Anxiety Inventory-2 Revised (CSAI-2R was administered prior to the pre- and post-intervention performance task. Dart-throwing gain scores were significantly higher for URM than for UAM and NM, with no significant difference between UAM and NM (URM = 37.24 ± 5.66, UAM = 17.57 ± 5.30, and NM = 13.19 ± 6.14, F2,62 = 5.03, p = 0.01, η2 = 0.14. GSR, PT, and HR reflected lower arousal for URM than for UAM or NM. Significant decreases in somatic anxiety were evident for URM and UAM but not NM. Significant decreases in cognitive anxiety were evident for URM and NM but not UAM. Significant increases in self-confidence were evident for URM but not UAM or NM. Performance improved in all three conditions but URM was associated with the largest performance gain, the lowest physiological indices of arousal, and the most positive CSAI-2R profiles. Listening to relaxing music during imagery may have benefits for

Injuries to the shoulder in the throwing athlete. Part two: evaluation/treatment.

Science.gov (United States)

Meister, K

2000-01-01

In part one of this three-part series (March/April 2000), I concentrated on summarizing the biomechanics of the normal throwing shoulder and the pathophysiology of injury. A classification of injury was presented that was based on the principles contained in that article. Part two of this series will focus on the evaluation and treatment of injuries, expanded from an understanding of the principles learned in part one. The ability to perform a skillful examination, and thus develop an accurate diagnosis, is the foundation for treatment. Fortunately, many difficulties encountered in a thrower's shoulder can be treated with a nonoperative approach. However, in instances where conservative measures fail, an improved understanding of the pathophysiology of injury and the development of improved surgical techniques are leading to more accurate diagnoses and more successful rates of return of the athlete to a premorbid level of activity.

Gesture Recognition and Sensorimotor Learning-by-Doing of Motor Skills in Manual Professions: A Case Study in the Wheel-Throwing Art of Pottery

Science.gov (United States)

Glushkova, Alina; Manitsaris, Sotiris

2018-01-01

This paper presents a methodological framework for the use of gesture recognition technologies in the learning/mastery of the gestural skills required in wheel-throwing pottery. In the case of self-instruction or training, learners face difficulties due to the absence of the teacher/expert and the consequent lack of guidance. Motion capture…

Can we throw information out of visual working memory and does this leave informational residue in long-term memory?

OpenAIRE

Ashleigh Monette Maxcey; Geoffrey F. Woodman

2014-01-01

Can we entirely erase a temporary memory representation from mind? This question has been addressed in several recent studies that tested the specific hypothesis that a representation can be erased from visual working memory based on a cue that indicated that the representation was no longer necessary for the task. In addition to behavioral results that are consistent with the idea that we can throw information out of visual working memory, recent neurophysiological recordings support this pr...

The effectiveness of snow cube throwing learning model based on exploration

Science.gov (United States)

Sari, Nenden Mutiara

2017-08-01

This study aimed to know the effectiveness of Snow Cube Throwing (SCT) and Cooperative Model in Exploration-Based Math Learning in terms of the time required to complete the teaching materials and student engagement. This study was quasi-experimental research was conducted at SMPN 5 Cimahi, Indonesia. All student in grade VIII SMPN 5 Cimahi which consists of 382 students is used as population. The sample consists of two classes which had been chosen randomly with purposive sampling. First experiment class consists of 38 students and the second experiment class consists of 38 students. Observation sheet was used to observe the time required to complete the teaching materials and record the number of students involved in each meeting. The data obtained was analyzed by independent sample-t test and used the chart. The results of this study: SCT learning model based on exploration are more effective than cooperative learning models based on exploration in terms of the time required to complete teaching materials based on exploration and student engagement.

Shoulder Rotator Muscle Dynamometry Characteristics: Side Asymmetry and Correlations with Ball-Throwing Speed in Adolescent Handball Players

Science.gov (United States)

Pontaga, Inese; Zidens, Janis

2014-01-01

The aim of the investigation was to: 1) compare shoulder external/internal rotator muscles’ peak torques and average power values and their ratios in the dominant and non-dominant arm; 2) determine correlations between shoulder rotator muscles’ peak torques, average power and ball-throwing speed in handball players. Fourteen 14 to 15-year-old male athletes with injury-free shoulders participated in the study (body height: 176 ± 7 cm, body mass 63 ± 9 kg). The tests were carried out by an isokinetic dynamometer system in the shoulder internal and external rotation movements at angular velocities of 60°/s, 90°/s and 240°/s during concentric contractions. The eccentric external– concentric internal rotator muscle contractions were performed at the velocity of 90°/s. The player threw a ball at maximal speed keeping both feet on the floor. The speed was recorded with reflected light rays. Training in handball does not cause significant side asymmetry in shoulder external/internal rotator muscle peak torques or the average power ratio. Positive correlations between isokinetic characteristics of the shoulder internal and external rotator muscles and ball-throwing speed were determined. The power produced by internal rotator muscles during concentric contractions after eccentric contractions of external rotator muscles was significantly greater in the dominant than in the non-dominant arm. Thus, it may be concluded that the shoulder eccentric external/concentric internal rotator muscle power ratio is significantly greater than this ratio in the concentric contractions of these muscles. PMID:25414738

Shoulder Rotator Muscle Dynamometry Characteristics: Side Asymmetry and Correlations with Ball-Throwing Speed in Adolescent Handball Players

Directory of Open Access Journals (Sweden)

Pontaga Inese

2014-10-01

Full Text Available The aim of the investigation was to: 1 compare shoulder external/internal rotator muscles’ peak torques and average power values and their ratios in the dominant and non-dominant arm; 2 determine correlations between shoulder rotator muscles’ peak torques, average power and ball-throwing speed in handball players. Fourteen 14 to 15- year-old male athletes with injury-free shoulders participated in the study (body height: 176 ± 7 cm, body mass 63 ± 9 kg. The tests were carried out by an isokinetic dynamometer system in the shoulder internal and external rotation movements at angular velocities of 60°/s, 90°/s and 240°/s during concentric contractions. The eccentric external- concentric internal rotator muscle contractions were performed at the velocity of 90°/s. The player threw a ball at maximal speed keeping both feet on the floor. The speed was recorded with reflected light rays. Training in handball does not cause significant side asymmetry in shoulder external/internal rotator muscle peak torques or the average power ratio. Positive correlations between isokinetic characteristics of the shoulder internal and external rotator muscles and ball-throwing speed were determined. The power produced by internal rotator muscles during concentric contractions after eccentric contractions of external rotator muscles was significantly greater in the dominant than in the non-dominant arm. Thus, it may be concluded that the shoulder eccentric external/concentric internal rotator muscle power ratio is significantly greater than this ratio in the concentric contractions of these muscles

Motor Experts Care about Consistency and Are Reluctant to Change Motor Outcome.

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Volker Kast

Full Text Available Thousands of hours of physical practice substantially change the way movements are performed. The mechanisms underlying altered behavior in highly-trained individuals are so far little understood. We studied experts (handballers and untrained individuals (novices in visuomotor adaptation of free throws, where subjects had to adapt their throwing direction to a visual displacement induced by prismatic glasses. Before visual displacement, experts expressed lower variability of motor errors than novices. Experts adapted and de-adapted slower, and also forgot the adaptation slower than novices. The variability during baseline was correlated with the learning rate during adaptation. Subjects adapted faster when variability was higher. Our results indicate that experts produced higher consistency of motor outcome. They were still susceptible to the sensory feedback informing about motor error, but made smaller adjustments than novices. The findings of our study relate to previous investigations emphasizing the importance of action exploration, expressed in terms of outcome variability, to facilitate learning.

Motor Experts Care about Consistency and Are Reluctant to Change Motor Outcome.

Science.gov (United States)

Kast, Volker; Leukel, Christian

2016-01-01

Thousands of hours of physical practice substantially change the way movements are performed. The mechanisms underlying altered behavior in highly-trained individuals are so far little understood. We studied experts (handballers) and untrained individuals (novices) in visuomotor adaptation of free throws, where subjects had to adapt their throwing direction to a visual displacement induced by prismatic glasses. Before visual displacement, experts expressed lower variability of motor errors than novices. Experts adapted and de-adapted slower, and also forgot the adaptation slower than novices. The variability during baseline was correlated with the learning rate during adaptation. Subjects adapted faster when variability was higher. Our results indicate that experts produced higher consistency of motor outcome. They were still susceptible to the sensory feedback informing about motor error, but made smaller adjustments than novices. The findings of our study relate to previous investigations emphasizing the importance of action exploration, expressed in terms of outcome variability, to facilitate learning.

High Isolation Single-Pole Four-Throw RF MEMS Switch Based on Series-Shunt Configuration

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Tejinder Singh

2014-01-01

Full Text Available This paper presents a novel design of single-pole four-throw (SP4T RF-MEMS switch employing both capacitive and ohmic switches. It is designed on high-resistivity silicon substrate and has a compact area of 1.06 mm2. The series or ohmic switches have been designed to provide low insertion loss with good ohmic contact. The pull-in voltage for ohmic switches is calculated to be 7.19 V. Shunt or capacitive switches have been used in each port to improve the isolation for higher frequencies. The proposed SP4T switch provides excellent RF performances with isolation better than 70.64 dB and insertion loss less than 0.72 dB for X-band between the input port and each output port.

PEMBELAJARANSNOWBALL THROWING DITINJAU DARIGAYA BELAJAR EKSTROVERT-INTROVERT

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Sulaiman Sulaiman

2018-02-01

Full Text Available ABSTRACT: The purpose of this study was to determine the results of students 'mathematics learning through cooperative learning model Snowball Throwingin terms of students' learning styles. The population of this research is all class VIII SMP Negeri 1 Adiluwih totaling 285 students. The sample was 70 students consisting of 35 students to a class of 35 students for the experimental and control classes were obtained by technique. cluster random sampling. The instrument used was a questionnaire and student mathematics achievement test. Data analysis techniques used a party t-test and t-test two parties. Based on t-test calculation of the two parties to the student's learning style extrovert, shows thitung = 3.07 and ttable = 2.021 at significance level of 5% that thitung > ttabel (3.07> 2,021, then H0 is rejected and  H1 received. For the t-test of the parties to the student's learning style extrovert show thitung = 3.07and ttabel = 1.684 at significance level of 5% that thitung > ttabel (3.07> 1.684, then H0  is rejected and  H1 accepted. T-test calculation of the two parties to the student's learning style introvert show thitung = -0.87 and ttabel = -2.069 at a significance level of 5% that thitung > ttabel (-0.87> -2.069, then H0 is  rejected and  H1  accepted. For the t-test for students' learning styles  introvertshow thitung = -0.87 and ttable = 1.714 at significance level of 5% that  thitung < ttabel   (-0.87 <1.714, then H0 is   rejected and H1 accepted.Key words: Snowball Throwing,learning style,ekstrovert, extrovert

The Effects of Shoulder- Girdle Muscles Fatigue on Ground Reaction Force, Elbow and Shoulder Joint Angle, and Accuracy of the Athletic Performance in Handball Penalty Throws

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Mona Shiravand

2017-09-01

Discussion: As the subjects were professional, muscle fatigue did not have a significant effect on postural control, angles and angular velocity; but did affect the reaction force and accuracy of the throws before and after fatigue, which could ultimately affect the performance of athletes and competition results.

20 CFR 404.1675 - Finding of substantial failure.

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2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Finding of substantial failure. 404.1675... DISABILITY INSURANCE (1950- ) Determinations of Disability Substantial Failure § 404.1675 Finding of substantial failure. A finding of substantial failure with respect to a State may not be made unless and until...

20 CFR 416.1075 - Finding of substantial failure.

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2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Finding of substantial failure. 416.1075... AGED, BLIND, AND DISABLED Determinations of Disability Substantial Failure § 416.1075 Finding of substantial failure. A finding of substantial failure with respect to a State may not be made unless and until...

The burden of secrecy? No effect on hill slant estimation and beanbag throwing.

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Pecher, Diane; van Mierlo, Heleen; Cañal-Bruland, Rouwen; Zeelenberg, René

2015-08-01

Slepian, Masicampo, Toosi, and Ambady (2012, Experiment 1) reported that participants who recalled a big secret estimated a hill as steeper than participants who recalled a small secret. This finding was interpreted as evidence that secrets are experienced as physical burdens. In 2 experiments, we tried to replicate this finding, but, despite larger power, did not find a difference in slant estimates between participants who recalled a big secret and those who recalled a small secret. This finding was further corroborated by a meta-analysis that included 8 published data sets of exact replications, which indicates that thinking of a big secret does not affect hill slant estimation. In a third experiment, we also failed to replicate the effect of recalling a secret on throwing a beanbag at a target (Slepian et al., 2012, Experiment 2). Together, our findings question the robustness of the original empirical findings. (c) 2015 APA, all rights reserved).

BASIC BIOMECHANICAL CHARACTERISTICS OF THE SECOND PHASE (TSUKURI OF JUDO THROWING TECHNIQUE OSOTO GARI

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Fadil Rexhepi

2011-09-01

Full Text Available In a sample of a total of 11 judoists - one was the Tori (thrower, and the other ten were uke (those who were thrown during the performance of throwing technique, was analyzed the second phase of throwing (tsukuri judo technique osoto gari. Tori is an active athlete superior quality (master, body mass = 72 kg, and all the other, who were thrown (uke differ from each other as the weight and height of the body concerned. The average of their body weight was 73.8 kg, which means that it is almost even with body mass of tori. For data collection was used a three-dimensional motion analysis system APAS (Ariel Performance Analysis System. Tsukuri is the phase where occur most actions of reaping leg. The second phase (tsukuri begins when tori detach his right foot and lasts until the beginning of reaping opponent's leg, on which was concentrated its weight (uke's weight. The parameters that describe the effect of the reaping leg in the second phase of technique osoto gari are crucial for the successful execution of this leg technique. For the analysis of the second phase of the throw were selected 14 variables that describe the position of the body and certain body parts of both athletes, velocity parameters of tori's reaping leg and the duration of this phase (time. The role of the tori's standing leg is to maintain a stable position during this phase, while the other leg quickly and in full force acts reaping. The smallest angle of the knee joint of standing leg during the second phase was 130.84 °. Before the moment of reaping, or detachment of uke`s feet from the mat, standing leg has a tendency to extension in the knee joint, which impacts positively on raising the tori's body center of mass. Height tori's body center of mass at the beginning phase was 87.79 cm. As a result of tori's action by pulling onto uke, but little to his left side, the uke`s center of mass at the end of this phase is moved laterally to 6.10 cm. The results show quite

Calculation of force and power during bench throws using a Smith machine: the importance of considering the effect of counterweights.

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Kobayashi, Y; Narazaki, K; Akagi, R; Nakagaki, K; Kawamori, N; Ohta, K

2013-09-01

For achieving accurate and safe measurements of the force and power exerted on a load during resistance exercise, the Smith machine has been used instead of free weights. However, because some Smith machines possess counterweights, the equation for the calculation of force and power in this system should be different from the one used for free weights. The purpose of this investigation was to calculate force and power using an equation derived from a dynamic equation for a Smith machine with counterweights and to determine the differences in force and power calculated using 2 different equations. One equation was established ignoring the effect of the counterweights (Method 1). The other equation was derived from a dynamic equation for a barbell and counterweight system (Method 2). 9 female collegiate judo athletes performed bench throws using a Smith machine with a counterweight at 6 different loading conditions. Barbell displacement was recorded using a linear position transducer. The force and power were subsequently calculated by Methods 1 and 2. The results showed that the mean and peak power and force in Method 1 were significantly lower relative to those of Method 2 under all loading conditions. These results indicate that the mean and peak power and force during bench throwing using a Smith machine with counterweights would be underestimated when the calculations used to determine these parameters do not account for the effect of counterweights. © Georg Thieme Verlag KG Stuttgart · New York.

An analysis of the relationship between the linear hammer speed and the thrower applied forces during the hammer throw for male and female throwers.

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Brice, Sara M; Ness, Kevin F; Rosemond, Doug

2011-09-01

The purpose of this study was to investigate the relationship between the cable force and linear hammer speed in the hammer throw and to identify how the magnitude and direction of the cable force affects the fluctuations in linear hammer speed. Five male (height: 1.88 +/- 0.06 m; body mass: 106.23 +/- 4.83 kg) and five female (height: 1.69 +/- 0.05 m; body mass: 101.60 +/- 20.92 kg) throwers participated and were required to perform 10 throws each. The hammer's linear velocity and the cable force and its tangential component were calculated via hammer head positional data. As expected, a strong correlation was observed between decreases in the linear hammer speed and decreases in the cable force (normalised for hammer weight). A strong correlation was also found to exist between the angle by which the cable force lags the radius of rotation at its maximum (when tangential force is at its most negative) and the size of the decreases in hammer speed. These findings indicate that the most effective way to minimise the effect of the negative tangential force is to reduce the size of the lag angle.

20 CFR 604.6 - Conformity and substantial compliance.

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2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Conformity and substantial compliance. 604.6... FOR ELIGIBILITY FOR UNEMPLOYMENT COMPENSATION § 604.6 Conformity and substantial compliance. (a) In... for the administration of its UC program. (b) Resolving Issues of Conformity and Substantial...

19 CFR 10.7 - Substantial containers or holders.

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2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Substantial containers or holders. 10.7 Section 10... Exported and Returned § 10.7 Substantial containers or holders. (a) Substantial containers or holders... domestic products exported and returned. When such containers or holders are imported not containing or...

[Experimental studies on the wounding capacity of recently developed shuriken/throwing stars and their legal categorization--an interdisciplinary view].

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Kettner, Mattias; Gade, Gunther; Ramsthaler, Frank; Shah, Sanjai; Pape, Andreas; Theisen, Alf; Schmidt, Peter

2010-01-01

Shuriken/throwing stars are traditional Japanese weapons for close combat situations. They vary greatly in shape and mode of action. Due to their wounding capacity traditional shuriken made of steel were prohibited in Germany in the 1980's. In the present study three recently developed types of shuriken were examined to determine their wounding capacity. Type 1 was made of plastic, whereas type 2 was a so-called cyclone shuriken equipped with three knives protruding from a discoidal center due to centrifugal force during the flight. Type 3 consisted of three traditional metal shuriken with blunt edges and peaks produced for decorative purposes. Experiments using pig carcasses were carried out for types 1 and 2. An experiment using human skin was performed with type 3 shuriken. An experienced thrower performed throws from a distance of 1, 2, 3, and 4 m with the shuriken made of plastic. For the cyclone shuriken a distance of 4 m was chosen to ensure the unfolding of the shuriken during flight. Type 3 shuriken were tested using a distance of 2 m. Penetration depths of the shuriken made of plastic reached up to 8 mm in pig skin. The experiment with the cyclone shuriken revealed a penetration depth of up to 2.5 cm cutting through the entire abdominal tissue and opening up an intestinal loop whereas type 3 shuriken yielded maximal penetration depths between 0.9 and 2.3 cm. This study indicates that all three types of shuriken may inflict lethal wounds upon opponents in close combat. The findings of this study should promote a public discussion whether the ban on traditional shuriken should be extended to the recently developed types.

Medical Ethics in Qiṣāṣ (Eye-for-an-Eye) Punishment: An Islamic View; an Examination of Acid Throwing.

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Alishahi Tabriz, Amir; Dabbagh, Hossein; Koenig, Harold G

2016-08-01

Physicians in Islamic countries might be requested to participate in the Islamic legal code of qiṣāṣ, in which the victim or family has the right to an eye-for-an-eye retaliation. Qiṣāṣ is only used as a punishment in the case of murder or intentional physical injury. In situations such as throwing acid, the national legal system of some Islamic countries asks for assistance from physicians, because the punishment should be identical to the crime. The perpetrator could not be punished without a physician's participation, because there is no way to guarantee that the sentence would be carried out without inflicting more injury than the initial victim had suffered. By examining two cases of acid throwing, this paper discusses issues related to physicians' participation in qiṣāṣ from the perspective of medical ethics and Islamic Shari'a law. From the standpoint of medical ethics, physicians' participation in qiṣāṣ is not appropriate. First, qiṣāṣ is in sharp contrast to the Hippocratic Oath and other codes of medical ethics. Second, by physicians' participation in qiṣāṣ, medical practices are being used improperly to carry out government mandates. Third, physician participation in activities that cause intentional harm to people destroys the trust between patients and physicians and may adversely affect the patient-physician relationship more generally. From the standpoint of Shari'a, there is no consensus among Muslim scholars whether qiṣāṣ should be performed on every occasion. We argue that disallowing physician involvement in qiṣāṣ is necessary from the perspectives of both medical ethics and Shari'a law.

Assessment and monitoring of ballistic and maximal upper-body strength qualities in athletes.

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Young, Kieran P; Haff, G Gregory; Newton, Robert U; Gabbett, Tim J; Sheppard, Jeremy M

2015-03-01

To evaluate whether the dynamic strength index (DSI: ballistic peak force/isometric peak force) could be effectively used to guide specific training interventions and detect training-induced changes in maximal and ballistic strength. Twenty-four elite male athletes were assessed in the isometric bench press and a 45% 1-repetition-maximum (1RM) ballistic bench throw using a force plate and linear position transducer. The DSI was calculated using the peak force values obtained during the ballistic bench throw and isometric bench press. Athletes were then allocated into 2 groups as matched pairs based on their DSI and strength in the 1RM bench press. Over the 5 wk of training, athletes performed either high-load (80-100% 1RM) bench press or moderate-load (40-55% 1RM) ballistic bench throws. The DSI was sensitive to disparate training methods, with the bench-press group increasing isometric bench-press peak force (P=.035, 91% likely), and the ballistic-bench-throw group increasing bench-throw peak force to a greater extent (P≤.001, 83% likely). A significant increase (P≤.001, 93% likely) in the DSI was observed for both groups. The DSI can be used to guide specific training interventions and can detect training-induced changes in isometric bench-press and ballistic bench-throw peak force over periods as short as 5 wk.

Modelling effects of tree population dynamics, tree throw and pit-mound formation/diffusion on microtopography over time in different forest settings

Science.gov (United States)

Martin, Y. E.; Johnson, E. A.; Gallaway, J.; Chaikina, O.

2011-12-01

Herein we conduct a followup investigation to an earlier research project in which we developed a numerical model of tree population dynamics, tree throw, and sediment transport associated with the formation of pit-mound features for Hawk Creek watershed, Canadian Rockies (Gallaway et al., 2009). We extend this earlier work by exploring the most appropriate transport relations to simulate the diffusion over time of newly-formed pit-pound features due to tree throw. We combine our earlier model with a landscape development model that can incorporate these diffusive transport relations. Using these combined models, changes in hillslope microtopography over time associated with the formation of pit-mound features and their decay will be investigated. The following ideas have motivated this particular study: (i) Rates of pit-mound degradation remain a source of almost complete speculation, as there is almost no long-term information on process rates. Therefore, we will attempt to tackle the issue of pit-mound degradation in a methodical way that can guide future field studies; (ii) The degree of visible pit-mound topography at any point in time on the landscape is a joint function of the rate of formation of new pit-mound features due to tree death/topple and their magnitude vs. the rate of decay of pit-mound features. An example of one interesting observation that arises is the following: it appears that pit-mound topography is often more pronounced in some eastern North American forests vs. field sites along the eastern slopes of the Canadian Rockies. Why is this the case? Our investigation begins by considering whether pit-mound decay might occur by linear or nonlinear diffusion. What differences might arise depending on which diffusive approach is adopted? What is the magnitude of transport rates associated with these possible forms of transport relations? We explore linear and nonlinear diffusion at varying rates and for different sizes of pit-mound pairs using a

Substantiation of vibration strength of nuclear reactor and steam generator internals. Main problems

International Nuclear Information System (INIS)

Fyodorov, V.G.; Sinyavasky, V.F.

1977-01-01

The report details the scope and priority of studies necessary for substantiation of vibration strength of steam generator tube bundles and reactor fuel assemblies, and design modifications helping to reduce flow-induced vibration of the internals specified. Steam generator tube bundles are studied on the basis of a standard establishing vibration requirements at various stages of design, manufacture and operation of a steam generator at a nuclear power station. The main vibration characteristics of tubes obtained through model and full-scale tests are compared with calculation results. Results are provided concerning test-stand vibration tests of fuel elements and fuel assemblies. (author)

Beyond Tree Throw: Wind, Water, Rock and the Mechanics of Tree-Driven Bedrock Physical Weathering

Science.gov (United States)

Marshall, J. A.; Anderson, R. S.; Dawson, T. E.; Dietrich, W. E.; Minear, J. T.

2017-12-01

Tree throw is often invoked as the dominant process in converting bedrock to soil and thus helping to build the Critical Zone (CZ). In addition, observations of tree roots lifting sidewalk slabs, occupying cracks, and prying slabs of rock from cliff faces have led to a general belief in the power of plant growth forces. These common observations have led to conceptual models with trees at the center of the soil genesis process. This is despite the observation that tree throw is rare in many forested settings, and a dearth of field measurements that quantify the magnitude of growth forces. While few trees blow down, every tree grows roots, inserting many tens of percent of its mass below ground. Yet we lack data quantifying the role of trees in both damaging bedrock and detaching it (and thus producing soil). By combing force measurements at the tree-bedrock interface with precipitation, solar radiation, wind speed, and wind-driven tree sway data we quantified the magnitude and frequency of tree-driven soil-production mechanisms from two contrasting climatic and lithologic regimes (Boulder and Eel Creek CZ Observatories). Preliminary data suggests that in settings with relatively thin soils, trees can damage and detach rock due to diurnal fluctuations, wind response and rainfall events. Surprisingly, our data suggests that forces from roots and trunks growing against bedrock are insufficient to pry rock apart or damage bedrock although much more work is needed in this area. The frequency, magnitude and style of wind-driven tree forces at the bedrock interface varies considerably from one to another species. This suggests that tree properties such as mass, elasticity, stiffness and branch structure determine whether trees respond to gusts big or small, move at the same frequency as large wind gusts, or are able to self-dampen near-ground sway response to extended wind forces. Our measurements of precipitation-driven and daily fluctuations in root pressures exerted on

Net-Zero Building Technologies Create Substantial Energy Savings -

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only an estimated 1% of commercial buildings are built to net-zero energy criteria. One reason for this Continuum Magazine | NREL Net-Zero Building Technologies Create Substantial Energy Savings Net -Zero Building Technologies Create Substantial Energy Savings Researchers work to package and share step

Diferencias en la condición física y en el lanzamiento entre jugadores de balonmano de elite y amateur. [Differences in physical fitness and throwing velocity between elite and amateur handball players

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Esteban Gorostiaga

2009-12-01

Full Text Available Resumen Para comparar la condición física y la velocidad de lanzamiento entre dos equipos de diferente nivel, 15 jugadores de elite (EM y 15 jugadores aficionados (AM de balonmano participaron en este estudio. Los sujetos fueron medidos en antropometría, 1RM en press de banca (BP, potencia muscular en BP y en media-sentadilla (HS, salto, carrera de máxima velocidad y resistencia aeróbica, y velocidad de lanzamiento. EM mostró mayor masa corporal, FFM y BMI, así como mayores valores de fuerza máxima absoluta, potencia muscular y velocidad de balón que AM. En ambos grupos se encontró correlaciones entre la velocidad de lanzamiento de 7m y la velocidad al 30% de 1RMBP. En EM, pero no en AM, se encontró correlación entre la velocidad de lanzamiento con 3 pasos en apoyo y la velocidad al 30% de 1RMBP, así como con la potencia al 100% de BMHS. Estos resultados sugieren que el desarrollo de fuerza máxima absoluta, y potencia muscular con cargas relativamente ligeras es importante para el éxito en balonmano. Palabras clave: velocidad de lanzamiento, diferentes niveles de jugadores de balonmano, potencia muscular y parámetros físicos.   Abstract To determine physical fitness and throwing velocity differences between different levels, 15 elite (EM and 15 amateur (AM male handball players were compared in this study. The subjects were tested in anthropometry, one 1RMBP, muscle power output in bench-press and half-squat, jump, sprint, endurance and throwing velocity. EM showed higher body mass, FFM and BMI, greater values in maximal absolute strength and muscle power and higher ball velocity than AM. Both showed relationships between 7m throwing velocity and velocity at 30% of 1RMBP. But only EM showed correlations between velocity at 30% of 1RMBP and power at 100% of BMHS with 3- steps running throwing velocity. The results suggest developing maximal absolute strength, and muscle power with relative light loads is important to success in

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to astaxanthin and protection of the skin from UV-induced damage (ID 1687, 1979), defence against Helicobacter pylori (ID 1686), contribution to normal spermatogenesis

DEFF Research Database (Denmark)

Tetens, Inge

claims in relation to astaxanthin and protection of the skin from UV-induced damage, defence against Helicobacter pylori, contribution to normal spermatogenesis, contribution to normal muscle function, and “immune system”. The scientific substantiation is based on the information provided by the Member...

20 CFR 654.13 - Determination of areas of substantial unemployment.

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2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of areas of substantial unemployment. 654.13 Section 654.13 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF... 10582 § 654.13 Determination of areas of substantial unemployment. An area of substantial unemployment...

Kinematic analysis of rugby lineout throws in the Six Nations Tournament. [Análisis cinemático de los saques de lateral en el Torneo de Rugby del Seis Naciones].

Directory of Open Access Journals (Sweden)

Ignacio Martín

2018-04-01

Full Text Available Abstract This study examines 126 successful, six- or seven-man lineouts of the 2013 Six Nations Tournament. Data were extracted from footage of the competition to calculate kinematic variables along with jumper position. Through cluster analysis, six types of throw were identified according to distance and velocity: short-fast, short-slow, medium short-fast, medium short-slow, medium long and long. Significant differences were detected in all the variables examined depending on the throw category (throw distance P<0.001; Partial eta square η2=0.932, height P=0.032; η2=0.096, flight time P<0.001; η2=0.789, starting angle P<0.001; η2=0.502, initial velocity P<0.001; η2=0.767 and jumper position P<0.001; η2=0.641. In the discriminant analysis, all variables except jumper position were able to correctly classify 100% of the throws. In addition, we differentiated the six participating teams, finding significant differences in throw height (Scotland vs England difference means d=0.32m, Ireland d=0.36m or France d=0.37m, flight time (Italy vs England d=0.34s or Ireland d=0.33s and angle (Italy vs England d=9.72º or Ireland d=8.49º and Scotland vs England d=8.27º or Ireland d=7.04º. Our findings have implications for training and team analysis (own and rival and also provide direction for future investigations. Resumen El presente estudio ha investigado 126 saques de lateral ganados con seis o siete jugadores en el alineamiento del torneo de las Seis Naciones de 2013 La observación se ha realizado a partir del estudio de los videos, por lo que los datos están extraídos en competición real. Un análisis cluster nos ha permitido establecer seis tipos de lanzamientos en función de la distancia y la velocidad: cortos-rápidos, cortos-lentos, mediocortos-rápidos, mediocortos-lentos, mediolargos y largos. Hemos encontrado diferencias significativas en todas las variables estudiadas en función de los tipos de lanzamiento (distancia del

γ-Tocotrienol does not substantially protect DS neurons from hydrogen peroxide-induced oxidative injury

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Then Sue-Mian

2012-01-01

Full Text Available Abstract Background Down syndrome (DS neurons are more susceptible to oxidative stress and previous studies have shown that vitamin E was able to reduce oxidative stress and improve DS neurons' viability. Therefore, this study was done to investigate the protective role of γ-tocotrienol (γT3 in DS neurons from hydrogen peroxide (H2O2 -induced oxidative stress. The pro-apoptosis tendency of γT3 was compared to α-tocopherol (αT in non-stress condition as well. Methods Primary culture of DS and euploid neurons were divided into six groups of treatment: control, H2O2, γT3 pre-treatment with H2O2, γT3 only, αT pre-treatment with H2O2 and αT only. The treatments were assessed by MTS assay and apoptosis assay by single-stranded DNA (ssDNA apoptosis ELISA assay, Hoechst and Neu-N immunofluorescence staining. The cellular uptake of γT3 and αT was determined by HPLC while protein expressions were determined by Western blot. Comparison between groups was made by the Student's t test, one-way ANOVA and Bonferroni adjustment as well as two-way ANOVA for multiple comparisons. Results One day incubation of γT3 was able to reduced apoptosis of DS neurons by 10%, however γT3 was cytotoxic at longer incubation period (14 days and at concentrations ≥ 100 μM. Pre-treatment of αT and γT3 only attenuate apoptosis and increase cell viability in H2O2-treated DS and euploid neurons by 10% in which the effects were minimal to maintain most of the DS cells' morphology. γT3 act as a free radical scavenger by reducing ROS generated by H2O2. In untreated controls, DS neurons showed lower Bcl-2/Bax ratio and p53 expression compared to normal neurons, while cPKC and PKC-δ expressions were higher in DS neurons. On the other hand, pre-treatment of γT3 in H2O2-treated DS neurons have reduced Bcl-2/Bax ratio, which was not shown in euploid neurons. This suggests that pre-treatment of γT3 did not promote DS cell survival. Meanwhile γT3 and αT treatments

Increased greenhouse effect substantiated through measurements

International Nuclear Information System (INIS)

Skartveit, Arvid

2001-01-01

The article presents studies on the greenhouse effect which substantiates the results from satellite measurements during the period 1970 - 1997. These show an increased effect due to increase in the concentration of the climatic gases CO 2 , methane, CFC-11 and CFC-12 in the atmosphere

19 CFR 134.35 - Articles substantially changed by manufacture.

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2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Articles substantially changed by manufacture. 134... substantially changed by manufacture. (a) Articles other than goods of a NAFTA country. An article used in the United States in manufacture which results in an article having a name, character, or use differing from...

21 CFR 514.4 - Substantial evidence.

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2010-04-01

... adequate and well-controlled studies, such as a study in a target species, study in laboratory animals... and conditions of use. Substantial evidence of effectiveness of a new animal drug shall demonstrate that the new animal drug is effective for each intended use and associated conditions of use for and...

Improvements Realized on the NiThrowTM Solution - 13075

International Nuclear Information System (INIS)

Moggia, F.; Objois, L.; Damerval, F.; Toulemonde, V.; Varet, T.; Guillot, S.; Richard, F.

2013-01-01

such as corners..). In this paper, the 'step by step' strategy to achieve those ambitious developments will be presented with a special attention to the NiThrow TM carrier development. (authors)

The Acute Effect of Upper-Body Complex Training on Power Output of Martial Art Athletes as Measured by the Bench Press Throw Exercise

Science.gov (United States)

Liossis, Loudovikos Dimitrios; Forsyth, Jacky; Liossis, Ceorge; Tsolakis, Charilaos

2013-01-01

The purpose of this study was to examine the acute effect of upper body complex training on power output, as well as to determine the requisite preload intensity and intra-complex recovery interval needed to induce power output increases. Nine amateur-level combat/martial art athletes completed four distinct experimental protocols, which consisted of 5 bench press repetitions at either: 65% of one-repetition maximum (1RM) with a 4 min rest interval; 65% of 1RM with an 8 min rest; 85% of 1RM with a 4 min rest; or 85% of 1RM with an 8 min rest interval, performed on different days. Before (pre-conditioning) and after (post-conditioning) each experimental protocol, three bench press throws at 30% of 1RM were performed. Significant differences in power output pre-post conditioning were observed across all experimental protocols (F=26.489, partial eta2=0.768, p=0.001). Mean power output significantly increased when the preload stimulus of 65% 1RM was matched with 4 min of rest (p=0.001), and when the 85% 1RM preload stimulus was matched with 8 min of rest (p=0.001). Moreover, a statistically significant difference in power output was observed between the four conditioning protocols (F= 21.101, partial eta2=0.913, p=0.001). It was concluded that, in complex training, matching a heavy preload stimulus with a longer rest interval, and a lighter preload stimulus with a shorter rest interval is important for athletes wishing to increase their power production before training or competition. PMID:24511352

Methodology for substantiation of the fast reactor fuel element serviceability

International Nuclear Information System (INIS)

Tsykanov, V.A.; Maershin, A.A.

1988-01-01

Methodological aspects of fast reactor fuel element serviceability substantiation are presented. The choice of the experimental program and strategies of its realization to solve the problem set in short time, taking into account available experimental means, are substantiated. Factors determining fuel element serviceability depending on parameters and operational conditions are considered. The methodological approach recommending separate studing of the factors, which points to the possibility of data acquisition, required for the development of calculational models and substantiation of fuel element serviceability in pilot and experimental reactors, is described. It is shown that the special-purpose data are more useful for the substantiation of fuel element serviceability and analytical method development than unsubstantial and expensive complex tests of fuel elements and fuel assemblies, which should be conducted only at final stages for the improvement of the structure on the whole

Establishing Substantial Equivalence: Proteomics

Science.gov (United States)

Lovegrove, Alison; Salt, Louise; Shewry, Peter R.

Wheat is a major crop in world agriculture and is consumed after processing into a range of food products. It is therefore of great importance to determine the consequences (intended and unintended) of transgenesis in wheat and whether genetically modified lines are substantially equivalent to those produced by conventional plant breeding. Proteomic analysis is one of several approaches which can be used to address these questions. Two-dimensional PAGE (2D PAGE) remains the most widely available method for proteomic analysis, but is notoriously difficult to reproduce between laboratories. We therefore describe methods which have been developed as standard operating procedures in our laboratory to ensure the reproducibility of proteomic analyses of wheat using 2D PAGE analysis of grain proteins.

Frequency of Loaded Road March Training and Performance on a Loaded Road March

Science.gov (United States)

1990-04-01

heart rate through the use of beta - blockers can substantially improve shooting accuracy (29, 44). Post road march decrements in the grenade throw may...the road march. An Increase in body tremors due to fatigue or an elevated post exercise heart rate may account for this. Whole body sway while aiming...a rifle is substantially increased even after a short period of exercise (39) and this may effect accuracy. Muscle tremors increase after brief or

Audience and coactuacion effects in free throw El efecto audiencia y el efecto coactuación en el lanzamiento a canasta

Directory of Open Access Journals (Sweden)

C. Tuero

2010-09-01

Full Text Available

The aim of this study was to analyse audience and coactor effects in a simple motor task, the free throw. Participants were 40 male high school students, aged 14 to 17 years, that were familiar (N = 20 or unfamiliar (N = 20 with the task proposed. Performance was examined while subjects acted in three different experimental situations: a alone; b in front of a passive audience of 10 peers; and c throwing together with a peer, with no external observation. Significant effects were observed for familiarity with the task (F1,38 = 79.9, P<0.001, experimental situation (alone, audience or coacting (F2,76 = 7.7, P< 0.001 and interaction (F2,76 = 4.7, P<0.01. Scores in each of the three sitautions were significantly higher for  the group familiar with the task. Both passive audience and presence of coactors significantly reduced number of scores in comparison to shots taken alone only in the group unfamiliar with the task. Our results confirm the importance of a better knowledge of social facilitation during performance of motor tasks in sport setting, and the necessity of considering both audience and coactor effects while learning new motor abilities.
KEY WORDS: social facilitation, free throw, audience.

El objeto del estudio fue analizar los efectos de audiencia y de la presencia de coactores en una tarea motora simple, el tiro a canasta.  Participaron un grupo de 40 estudiantes de ESO del sexo masculino, con edades comprendidas entre 14 y 17 años, familiarizados (N = 20 o no familiarizados (N = 20 con la tarea propuesta, encestes en 20 lanzamientos desde la línea de tiros libres. Se examinó la actuación de los sujetos mientras lanzaban en tres situaciones experimentales: a solos, b ante un grupo de 10 compañeros que actuaban como observadores pasivos, y c realizando los lanzamientos junto con un compañero sin que nadie más les observase

26 CFR 1.42-7 - Substantially bond-financed buildings. [Reserved

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Substantially bond-financed buildings. [Reserved] 1.42-7 Section 1.42-7 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Credits Against Tax § 1.42-7 Substantially bond-financed buildings. [Reserved] ...

Change in power output across a high-repetition set of bench throws and jump squats in highly trained athletes.

Science.gov (United States)

Baker, Daniel G; Newton, Robert U

2007-11-01

Athletes experienced in maximal-power and power-endurance training performed 1 set of 2 common power training exercises in an effort to determine the effects of moderately high repetitions upon power output levels throughout the set. Twenty-four and 15 athletes, respectively, performed a set of 10 repetitions in both the bench throw (BT P60) and jump squat exercise (JS P60) with a resistance of 60 kg. For both exercises, power output was highest on either the second (JS P60) or the third repetition (BT P60) and was then maintained until the fifth repetition. Significant declines in power output occurred from the sixth repetition onwards until the 10th repetition (11.2% for BT P60 and 5% for JS P60 by the 10th repetition). These findings suggest that athletes attempting to increase maximal power limit their repetitions to 2 to 5 when using resistances of 35 to 45% 1RM in these exercises.

Determination of the free throw incidence in final score by means of statistical analysis Determinación de la incidencia del tiro libre en el resultado final a través del análisis estadístico 1

Directory of Open Access Journals (Sweden)

J. Rojas

2010-09-01

Full Text Available

The basic rules of basketball determine the principal aim of this game, which is to get a bigger score than opposite team. The use of all the individual or collective technical-tactical contents are oriented to achieve this objective. Between the different kind of shots, the only one which can be considered as a close task is the free throw, which means that it is developed in a stable environment. Despite of that the accuracy percentage obtained in real competition are really far away from the ideal results. This work try to analyse the incidence of free throw in the final score of the official games as a start point to revise deepthly about the methodological process of training.
KEY WORDS: Basketball, Free Throw

Las reglas de juego del baloncesto determinan que el objetivo del mismo es conseguir un mayor número de encestes que el equipo rival. La utilización de todos los contenidos técnico-tácticos ya sean individuales como colectivos, van orientados a conseguir dicho objetivo. Dentro de los diferentes tipos de lanzamientos, el de tiros libres es el único que puede ser considerado como tarea cerrada, es decir, desarrollado en unas condiciones estables, a pesar de lo cual, los porcentajes de eficacia obtenidos en competición se alejan de lo ideal. Este estudio pretende analizar la verdadera incidencia del tiro libre sobre el resultado del encuentro como punto de partida para hacer una revisión profunda de la metodología de entrenamiento.
PALABRAS CLAVE: Baloncesto y Tiro Libre

Effects of 18-week in-season heavy-resistance and power training on throwing velocity, strength, jumping, and maximal sprint swim performance of elite male water polo players.

Science.gov (United States)

Ramos Veliz, Rafael; Requena, Bernardo; Suarez-Arrones, Luis; Newton, Robert U; Sáez de Villarreal, Eduardo

2014-04-01

We examined the effects of 18 weeks of strength and high-intensity training on key sport performance measures of elite male water polo (WP) players. Twenty-seven players were randomly assigned to 2 groups, control (in-water training only) and strength group, (strength training sessions [twice per week] + in-water training). In-water training was conducted 5 d·wk. Twenty-meter maximal sprint swim, maximal dynamic strength 1-repetition maximum (1RM) for upper bench press (BP) and lower full squat (FS) body, countermovement jump (CMJ), and throwing velocity were measured before and after the training. The training program included upper and lower body strength and high-intensity exercises (BP, FS, military press, pull-ups, CMJ loaded, and abs). Baseline-training results showed no significant differences between the groups in any of the variables tested. No improvement was found in the control group; however, meaningful improvement was found in all variables in the experimental group: CMJ (2.38 cm, 6.9%, effect size [ES] = 0.48), BP (9.06 kg, 10.53%, ES = 0.66), FS (11.06 kg, 14.21%, ES = 0.67), throwing velocity (1.76 km·h(-1), 2.76%, ES = 0.25), and 20-m maximal sprint swim (-0.26 seconds, 2.25%, ES = 0.29). Specific strength and high-intensity training in male WP players for 18 weeks produced a positive effect on performance qualities highly specific to WP. Therefore, we propose modifications to the current training methodology for WP players to include strength and high-intensity training for athlete preparation in this sport.

26 CFR 1.528-4 - Substantiality test.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Substantiality test. 1.528-4 Section 1.528-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED... residence. Units which are used for purposes auxiliary to residential use (such as laundry areas, swimming...

Improvements Realized on the NiThrow{sup TM} Solution - 13075

Energy Technology Data Exchange (ETDEWEB)

Moggia, F.; Objois, L.; Damerval, F. [AREVA - Clean-Up BU - 1, route de la Noue - 91196 Gif-sur-Yvette (France); Toulemonde, V. [AREVA - R and D Corporate - 1, place Jean Miller - 92084 - Paris La Defense (France); Varet, T. [AREVA - D and D BU - 1, place Jean Miller - Paris La Defense (France); Guillot, S. [AREVA Federal Services LLC - 2101 Horn Rapids Road Richland, WA 99354-5102 (United States); Richard, F. [Air Liquide - Research Center - 13, rue d' Epluches - 95310 St Ouen L' Aumone (France)

2013-07-01

the singularities such as corners..). In this paper, the 'step by step' strategy to achieve those ambitious developments will be presented with a special attention to the NiThrow{sup TM} carrier development. (authors)

Influence of bench press exercise modality on the iso-inertial performance

OpenAIRE

Jidovtseff, Boris; Croisier, Jean-Louis; Crielaard, Jean-Michel

2006-01-01

Introduction. - This study used an iso-inertial dynamometer to investigate the influence of counter-movement and barbell throwing during bench press exercise. A critical analysis of these modalities during muscular evaluation was also performed. Methods. - The action of muscle stretch during the counter-movement induced an increase in average velocity and a shortening of the time to reach the peak power and peak velocity. The barbell throwing did not alter the initial part of the movement yet...

Toward More Substantial Theories of Language Acquisition

Science.gov (United States)

Jenson, Cinnamon Ann

2015-01-01

Cognitive linguists argue that certain sets of knowledge of language are innate. However, critics have argued that the theoretical concept of "innateness" should be eliminated since it is ambiguous and insubstantial. In response, I aim to strengthen theories of language acquisition and identify ways to make them more substantial. I…

Assessment of shoulder external rotation range-of-motion on throwing athletes: the effects of testing end-range determination (active versus passive).

Science.gov (United States)

Ribeiro, A; Pascoal, A

2015-07-01

The purpose of this study was to compare the effects of active or passive end-range determination (supine position) for external rotation range of motion (ROM) in overhead throwing athletes and verify if athletes' ROM is similar to non-athletes. Kinematic data from the dominant shoulder of 24 healthy male subjects, divided into two groups (12 athletes and 12 non-athletes) were recorded at end-range external rotation, thoracohumeral and glenohumeral external rotation angles were compared and a 2-way repeated-measures ANOVA was used to calculate the effects of end-range determination (passive versus active) across groups (athlete and non-athlete). A significant main effect (p external end-range angles was observed while the highest end-range determination values were associated with passive motion. No differences were observed between the athletic or non-athletic groups for either thoracohumeral (p = 0.784) or glenohumeral (p = 0.364) motion.

Reliability assessment of ballistic jump squats and bench throws.

Science.gov (United States)

Alemany, Joseph A; Pandorf, Clay E; Montain, Scott J; Castellani, John W; Tuckow, Alexander P; Nindl, Bradley C

2005-02-01

The purpose of this investigation was to determine the test-retest reliability and coefficient of variation of 2 novel physical performance tests. Ten healthy men (22.0 +/- 3.0 years, 87.0 +/- 8.0 kg, 20.0 +/- 5.0% body fat) performed 30 continuous and dynamic jump squats (JS) and bench throws (BT) on 4 separate occasions. The movements were performed under loaded conditions utilizing 30% of subject's predetermined 1 repetition maximum in the back squat and bench press. Mean power (MP; W), peak power (PP; W), mean velocity (MV; m.s(-1)), peak velocity (PV; m.s(-1)), and total work (TW; J) were assessed using a ballistic measurement system (Innervations Inc., Muncie, IN). Data were analyzed using repeated measures analysis of variance with Duncan's post hoc test when mean differences were p < or = 0.05. Intraclass correlation coefficient (ICC) and within-subject coefficient of variation (CV%) were also calculated. All values are presented as mean +/- SE. BT variables were statistically similar across the 4 sessions: MP (350.0 +/- 13.9 W), PP (431.4 +/- 18.5 W) MV (1.6 +/- 0.03 m.s(-1)), PV (2.0 +/- 0.03 m.s(-1)), and TW (199.1 +/- 7.2 J). For JS, session 3 PP (1,669.8 +/- 111.2 W) was significantly greater vs. sessions 1, 2, and 4 (1,601.2 +/- 58.4 W). Session 4 MP (1,403.2 +/- 88.6 W) and MV (1.9 +/- 0.1 m.s(-1)) for JS were significantly lower during sessions 1, 2, and 3 (MP: 1,479.4.5 +/- 44.8 W, MV: 2.0 +/- 0.05 m.s(-1)). TW (834.7 +/- 24.3 J) and PV (2.2 +/- 0.04 m.s(-1)) were statistically similar during all sessions for JS. The CVs ranged from 3.0 to 7.6% for the BT and 3.2 to 5.7% for the JS. ICCs for MP, PP, MV, PV, and TW were 0.92, 0.95, 0.94, 0.91, and 0.95, respectively, during BT. ICCs during JS for MP, PP, MV, PV, and TW were 0.96, 0.98, 0.94, 0.94, and 0.89, respectively. The results of the current study support the use of a 30 continuous and dynamic BT protocol as a reliable upper-body physical performance test, which can be administered with

Kinesthetic motor imagery training modulates frontal midline theta during imagination of a dart throw.

Science.gov (United States)

Weber, E; Doppelmayr, M

2016-12-01

Motor imagery (MI) is a frequently used and effective method for motor learning in sports as well as in other domains. Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) studies indicated that experts within a certain sport exhibit a more pronounced brain activity during MI as compared to novices. Similar to the execution, during MI the motor sequence has to be planned. Thus, the frontal attentional system, in part represented by the frontal midline theta (4-7Hz), is closely related to these processes and presumably plays a major role in MI as well. In this study, a MI dart training and its impact on frontal midline theta activity (fmt) during MI are examined. 53 healthy subjects with no prior dart experience were randomly allocated to a kinesthetic training group (KinVis) or to a control group (Control). Both groups performed 15 training sessions. While in the KinVis group dart throwing was accompanied by MI, the Control group trained without MI. Dart performance and fmt activity during MI within the first and the 15th session were compared. As expected, the performance increase was more pronounced in the KinVis group. Furthermore, frontal theta amplitude was significantly increased in the KinVis group during MI in the 15th training session as compared to the baseline. These results confirm the effectivity of MI. The enhanced fmt activity in the KinVis group can be interpreted as a better allocation of the requested resources in the frontal attentional network after MI. Copyright © 2016 Elsevier B.V. All rights reserved.

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to a combination of lycopene, vitamin E, lutein and selenium and protection of the skin from UV-induced (including photo-oxidative) damage pursuant to Article 13

DEFF Research Database (Denmark)

Tetens, Inge

related to a combination of lycopene, vitamin E, lutein and selenium and protection of the skin from UV-induced (including photo-oxidative) damage. The Panel considers that the combination of lycopene, vitamin E, lutein and selenium is sufficiently characterised. The claimed effect refers to the photo...... could be drawn from this study for the scientific substantiation of the claim. The Panel concludes that a cause and effect relationship has not been established between the consumption of a combination of lycopene, vitamin E, lutein and selenium and protection of the skin from UV-induced (including......-protective activity of the food, delaying the appearance of UV-induced erythema and decreasing its intensity. The target population proposed by the applicant is healthy adults in the general population, and in particular people with sensitive skin. The Panel considers that protection of the skin from UV...

76 FR 63846 - Substantially Underserved Trust Areas (SUTA)

Science.gov (United States)

2011-10-14

... Cost Rural Communities; 10.861, Public Television Station Digital Transition Grant Program; 10.862... rule do not impose substantial unreimbursed direct compliance costs on Indian tribal, Alaska native, or native Hawaiian governments and sovereign institutions or have tribal implications that preempt tribal...

SUBSTANTIATION OF SOLUTIONS PERTAINING TO COMPLEX PRODUCTION RECONSTRUCTION

Directory of Open Access Journals (Sweden)

V. Y. Gurinovich

2011-01-01

Full Text Available While taking an example of reconstruction and modernization of OJSC «Construction and Mounting Trust No.16, Novopolotsk» the paper substantiates solutions for complex production reconstruction. The production reconstruction is divided in three start-up facilities ensuring continuous finished-product output.

Substantiation of Optimum Stoker Number in Potassium Production by Game Method

Directory of Open Access Journals (Sweden)

B. A. Bogatov

2005-01-01

Full Text Available Dump formation process of hard halite waste in potassium production has been analyzed in the paper. The paper shows high cost of a salt dump formation and an actuality to substantiate number of ОШ-1900-110/150 stokers that are operating simultaneously. A game theory method has been used to substantiate a solution of the problem.

32 CFR 48.302 - Substantiating evidence regarding dependency and age of dependents.

Science.gov (United States)

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Substantiating evidence regarding dependency and age of dependents. 48.302 Section 48.302 National Defense Department of Defense OFFICE OF THE... Designation of Beneficiaries § 48.302 Substantiating evidence regarding dependency and age of dependents. At...

Patients' substantialization of disease, the hybrid symptom and metaphysical care.

Science.gov (United States)

Pârvan, Alexandra

2015-06-01

In the context of current scholarship concerned with facilitating integration between the biomedical and the patient-centred models of care, the article suggests that disease brings about an ontological disruption in patients, which is not directly addressed in either model, and may interfere with treatment and therapy outcomes if not met with a type of care termed here as 'metaphysical'. The receipt of diagnosis and medical care can give patients the sense that they are ontologically diminished, or less of a human, and along with physicians' approaches to and discourses about disease, may prompt them to seek ontological restoration or security in the same way as psychologically traumatized patients sometimes do: by treating the disease and/or the experience of harm associated with it as a thing that exists per se. I call this 'substantialization' of disease (or harm) and draw on Augustine's theory of non-substantial deficiencies (physiological and moral) and on Plato's and Plotinus's different takes on such defects in order to discuss what substantialization can do for patients. Based on literature that examines patients' ways of talking about and living with their disease, I speculate that substantialization can generate a 'hybrid symptom', consisting in patterns of exercising agency which may predispose to non-adherence. Ways in which physicians could provide metaphysical care are proposed, along with an understanding of chronic patients as hybrid ontological and agentic units, which draws on theories of enactive cognition. I opine that metaphysical care may facilitate integration between the depersonalized and personalized models of care. © 2014 John Wiley & Sons, Ltd.

Child protection decisions to substantiate hospital child protection teams' reports of suspected maltreatment.

Science.gov (United States)

Jedwab, Merav; Benbenishty, Rami; Chen, Wendy; Glasser, Saralee; Siegal, Gil; Lerner-Geva, Liat

2015-02-01

The present study focuses on the way child protection officers (CPOs) in Israel assess suspected abuse and neglect (SCAN) reports made by hospital child protection teams (CPTs), to determine whether the alleged maltreatment is substantiated. The study was conducted in six medical centers and included 358 reports investigated by CPOs for SCAN. A structured questionnaire was completed by hospital CPTs to capture all relevant information on each child referred to the CPTs. Structured phone interviews were conducted with each of the CPOs who received a CPT report. Bivariate associations and multivariate logistic regressions were conducted to estimate the substantiation rate of cases reported by CPTs and the types of maltreatment substantiated, as well as to identify case characteristics of the child and the family that were associated with the CPOs' substantiation decision. CPO follow-up investigations revealed a substantiation rate of 53.5%. The maltreatment type most commonly substantiated was neglect. The case characteristics associated with substantiation included socio-demographic background, parents' health and functioning, previous contact with social services, characteristics of the hospital referral, medical findings and an assessment of the parents' behaviors. The findings of the study highlighted the importance of cooperation between the health and welfare services and the policy makers. This cooperation is essential for identifying early signs of maltreatment. Enhanced cooperation and effective information transfer between various professionals would help prevent or at least reduce the recurrence of maltreatment and would ensure that the children and their families are treated appropriately. Copyright © 2014 Elsevier Ltd. All rights reserved.

A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsy

Science.gov (United States)

Grabenstatter, Heidi L.; Dudek, F. Edward

2010-01-01

Purpose Animal models with spontaneous epileptic seizures may be useful in the discovery of new antiepileptic drugs (AEDs). The purpose of the present study was to evaluate the efficacy of carisbamate on spontaneous motor seizures in rats with kainate-induced epilepsy. Methods Repeated, low-dose (5 mg/kg), intraperitoneal injections of kainate were administered every hour until each male Sprague-Dawley rat had experienced convulsive status epilepticus for at least 3 h. Five 1-month trials (n= 8–10 rats) assessed the effects of 0.3, 1, 3, 10 and 30 mg/kg carisbamate on spontaneous seizures. Each trial involved six AED-versus-vehicle tests comprised of carisbamate or 10% solutol-HS-15 treatments administered as intraperitoneal injections on alternate days with a recovery day between each treatment day. Results Carisbamate significantly reduced motor seizure frequency at doses of 10 and 30 mg/kg, and caused complete seizure cessation during the 6-h post-drug epoch in 7 of 8 animals at 30 mg/kg. The effects of carisbamate (0.3–30 mg/kg) on spontaneous motor seizures appeared dose dependent. Conclusions These data support the hypothesis that a repeated-measures, cross-over protocol in animal models with spontaneous seizures is an effective method for testing AEDs. Carisbamate reduced the frequency of spontaneous motor seizures in a dose-dependent manner, and was more effective than topiramate at reducing seizures in rats with kainate-induced epilepsy. PMID:18494790

Cumulative stress and substantiated maltreatment: the importance of caregiver vulnerability and adult partner violence.

Science.gov (United States)

Wekerle, Christine; Wall, Anne-Marie; Leung, Eman; Trocmé, Nico

2007-04-01

Our goal is to assess the effect of caregiver vulnerabilities, singly and in combination, on the substantiation of child abuse (physical, sexual) and neglect, while controlling for relevant background variables. We test the moderator role of adult partner violence in qualifying the relationship between caregiver vulnerabilities and maltreatment substantiation. Secondary analyses of the 1998 Canadian Incidence Study of Reported Child Maltreatment (CIS) are used to predict child protective service investigation substantiation versus non-substantiation from a range of caregiver vulnerability factors. Involvement in partner violence was examined as a moderator in the relation between caregiver vulnerabilities and maltreatment substantiation. The CIS is an epidemiological survey of first-reported cases to child protective services, using a random sample of child welfare agencies across Canada. Child welfare workers completed a research form on the child, primary caregiver, family, perpetrator, severity and type of maltreatment, as well as services and court outcomes. All maltreatment classifications were assigned according to the Canadian legal definition of child abuse and neglect. Hierarchical logistic regression analyses were used, with stepped entry of: (1) demographic factors, socioeconomic disadvantage, and caregiver's own history of maltreatment; (2) caregiver vulnerability factors; (3) involvement in partner violence; (4) the interaction between caregiver vulnerability and partner violence. Caregiver substance abuse was found to be the single most potent kind of caregiver vulnerability in predicting maltreatment substantiation. When the total number of vulnerabilities was used as the predictor, prediction across all types of maltreatment increased, especially for substantiated neglect. Analyses also showed that the presence of partner violence in the home exacerbated the effect of caregiver vulnerability on substantiation. The total number of caregiver

Aqueous Extract of Oldenlandia diffusa Suppresses LPS-Induced ...

African Journals Online (AJOL)

... potential transcriptional factor for regulating the expression of iNOS, COX-2 and TNF-α. As expected, AEOD suppressed the LPS-induced degradation and phosphorylation of IκBα and sustained the expression of p65 in the cytosol. Furthermore, AEOD substantially inhibited the LPS-induced DNA binding activity of NF-κB.

Using 10Be erosion rates and fluvial channel morphology to constrain fault throw rates in the southwestern Sacramento River Valley, California, USA

Science.gov (United States)

Cyr, A. J.

2013-12-01

The Sacramento - San Joaquin River Delta, California, USA, is a critical region for California water resources, agriculture, and threatened or endangered species. This landscape is affected by an extensive set of levees that enclose artificial islands created for agricultural use. In addition to their importance for sustaining agriculture, this levee system also supports extensive transport and power transmission infrastructure and urban/suburban development. These levees are susceptible to damage from even moderate ground shaking by either a large earthquake on one of the high-activity faults in the nearby San Francisco Bay region, or even a moderate earthquake on one of the low-activity faults in the Delta region itself. However, despite this danger the earthquake hazards in this region are poorly constrained due to our lack of understanding of faults in and near the Delta region. As part of an effort to better constrain the seismic hazard associated with known, but poorly constrained, faults in the region, a geomorphic analysis of the Dunnigan Hills, northwest of Woodland, CA, is being combined with cosmogenic 10Be catchment-averaged erosion rates. The Dunnigan Hills are a low-relief (maximum elevation 87 m) landscape generated by fault-bend folding above the west-vergent Sweitzer reverse fault that soles into a blind east-vergent reverse fault. These faults have been imaged by seismic reflection data, and local microseismicity indicates that this system is actively propagating to the east. However, the throw rates on the faults in this system remain unconstrained, despite the potential for significant shaking such as that experienced in the nearby April, 1892 earthquake sequence between Winters and Vacaville, Ca, ~25 km to the south, which has been estimated at magnitude 6.0 or greater. Geomorphic and cosmogenic 10Be analyses from 12 catchments draining the eastern flank of the Dunnigan Hills will be used to infer vertical rock uplift rates to better constrain

Domestic violence, parental substance misuse and the decision to substantiate child maltreatment.

Science.gov (United States)

Victor, Bryan G; Grogan-Kaylor, Andrew; Ryan, Joseph P; Perron, Brian E; Gilbert, Terri Ticknor

2018-05-01

Families that experience domestic violence and parental substance misuse are disproportionately involved with the child welfare system. Prior research suggests that child protective services (CPS) caseworkers are more likely to substantiate maltreatment allegations when domestic violence and parental substance misuse are identified during the investigation, pointing to one possible mechanism for this disproportionate involvement. While previous studies have relied on nationally representative data sets, the current study used administrative records from a large Midwestern child welfare agency that accounts for state-level variation in child welfare policy and practice. A total of 501,060 substantiation decisions made between 2009 and 2013 were examined to assess the influence of caseworker-perceived domestic violence and parental substance misuse on the decision to substantiate reported maltreatment. Results from multilevel modeling suggest that the identification of domestic violence and parental substance misuse during an investigation significantly increased the probability that an allegation would be substantiated. The implication of these findings for child welfare practice are considered in light of the fact that many child welfare agencies do not consider exposure to domestic violence and parental substance misuse in and of themselves to constitute child maltreatment. Copyright © 2018 Elsevier Ltd. All rights reserved.

Engineering Substantially Prolonged Human Lifespans: Biotechnological Enhancement and Ethics

NARCIS (Netherlands)

Derkx, P.H.J.M.

2006-01-01

Substantial extension of the human lifespan has recently become a subject of lively debate. One reason for this is the completion in 2001 of the Human Genome Project and the experimental avenues for biogerontological research it has opened. Another is recent theoretical progress in biogerontology.

Traffic forecasts ignoring induced demand

DEFF Research Database (Denmark)

Næss, Petter; Nicolaisen, Morten Skou; Strand, Arvid

2012-01-01

the model calculations included only a part of the induced traffic, the difference in cost-benefit results compared to the model excluding all induced traffic was substantial. The results show lower travel time savings, more adverse environmental impacts and a considerably lower benefitcost ratio when...... induced traffic is partly accounted for than when it is ignored. By exaggerating the economic benefits of road capacity increase and underestimating its negative effects, omission of induced traffic can result in over-allocation of public money on road construction and correspondingly less focus on other...... performance of a proposed road project in Copenhagen with and without short-term induced traffic included in the transport model. The available transport model was not able to include long-term induced traffic resulting from changes in land use and in the level of service of public transport. Even though...

Throw the bathwater out but save the baby: new perspectives in Critical Theory

Directory of Open Access Journals (Sweden)

Giacomo PEZZANO

2016-11-01

Full Text Available In this paper, I discuss the status of critical theory and thinking, claiming that we should not throw the baby out with the bathwater: if a certain way of conceiving and practicing it has nowadays become partial and unfit, then it’s not true that it is qua tale useless, old-fashioned, or dead. I start stressing that, in general, Critical Theory highlights that there is a problematic relation between individuals and social structure, which has to be pointed out, to indicate actual and possible transformations. Then, I propose a heuristic distinction between two main paradigms of Critical Theory and thinking (the modern Critical Theory and the postmodern Critical Theory, discussing three main aspects, separated but intertwined. The first is more strictly philosophical, involving the problem of the transcendent or immanent position of the critique: on the one hand, we have the external condemnation of the society, in the name of some kind of superior truth; on the other hand, we have the inner problematization of a given social field, according to criteria that have been posited by itself or that are implicit in it (§ 1. The second is more strictly anthropological, dealing with the problem of human nature and alienation: on the one hand, we have the hope for the restoration of a lost state of originary plenitude; on the other hand, we have the effort of learning the better way to deal with human openness and relationality (§ 2. The third is more strictly sociological, posing the question of ways and forms of life: on the one hand, we have an ironical attitude, aiming to elaborate a true counter-society that should take the place of the false present one; on the other hand, we have a humoristic attitude, that attempts to make the problem that a society both poses and tries to answer a problem that reemerges, so that it can be again for the first time seen as a problem (§ 3.

A Comparison between Bench Press Throw and Ballistic Push-Up tests to assess upper-body power in trained individuals.

Science.gov (United States)

Bartolomei, Sandro; Nigro, Federico; Ruggeri, Sandro; Lanzoni, Ivan Malagoli; Ciacci, Simone; Merni, Franco; Sadres, Eliahu; Hoffman, Jay R; Semprini, Gabriele

2018-03-06

The purpose of the present study was to validate the ballistic push-up test performed with hands on a force plate (BPU) as a method to measure upper-body power. Twenty-eight experienced resistance trained men (age = 25.4 ± 5.2 y; body mass = 78.5 ± 9.0 kg; body height = 179.6 ± 7.8 cm) performed, two days apart, a bench press 1RM test and upper-body power tests. Mean power and peak power were assessed using the bench press throw test (BT) and the BPU test performed in randomized order. The area under the force/power curve (AUC) obtained at BT was also calculated. Power expressed at BPU was estimated using a time-based prediction equation. Mean force and the participant's body weight were used to predict the bench press 1RM. Pearson product moment correlations were used to examine relationships between the power assessment methods and between the predicted 1RM bench and the actual value. Large correlations (0.79; p bench and the 1RM predicted by the BPU. Results of the present study indicate that BPU represents a valid and reliable method to estimate the upper-body power in resistance-trained individuals.

Detection of Dew-Point by substantial Raman Band Frequency Jumps (A new Method)

DEFF Research Database (Denmark)

Hansen, Susanne Brunsgaard; Berg, Rolf W.; Stenby, Erling Halfdan

Detection of Dew-Point by substantial Raman Band Frequency Jumps (A new Method). See poster at http://www.kemi.dtu.dk/~ajo/rolf/jumps.pdf......Detection of Dew-Point by substantial Raman Band Frequency Jumps (A new Method). See poster at http://www.kemi.dtu.dk/~ajo/rolf/jumps.pdf...

LETTER TO THE EDITOR: James Bond escapes from slippery ice - how?

Science.gov (United States)

2000-07-01

frame, where both were thrown together. Why do you have to throw the second shoe with extra effort? It is going the wrong way when you start to throw it, because the other shoe left Bond going in the opposite direction already. Thus, you throw the first shoe with less than maximum effort and use the leftover energy (somehow?)Â to throw the second shoe extra hard, so they both come out going at the same speed after both have been thrown. If you cannot transfer power from one shoe-throwing arm muscle group to the other arm, then you will use only equal exertion on both shoes, and the second shoe will come out going slower than the first. It was going the wrong way, remember, when you started to throw it, after a delay - any delay. This difference could have been substantial if Bond were throwing bowling balls. A heavy (second) ball will be going the wrong direction with more momentum before you try to start throwing it in the other direction, the direction that the first (heavy) ball was thrown in. It is a cute problem. Suppose that you have hundreds of shoes in a rocket, or in Santa's sleigh, and can only throw one at a time, for some reason, using a machine that you charge with energy to fire it. Best rocket recoil speed will occur when you throw the first shoe out with low speed and increase the charge of the gun with each subsequent shoe shot, such that all the shoes come out moving at the same speed when you are done, as seen in an inertial frame outside the ship. If the shoes have different final energies in this frame, I think the recoil speed of the ship will not be as large. These subtle differences must come from momentum being linearly related to the speed and energy being related to speed squared. Can you prove me wrong? Can you see a simple reason why this must be correct, if it is? This would also apply to ion beam rockets. They can control the acceleration voltage for the beam of ions that they throw out the back. These engines run for a long time, perhaps

On the structure and surface chemical composition of indium-tin oxide films prepared by long-throw magnetron sputtering

International Nuclear Information System (INIS)

Chuang, M.J.; Huang, H.F.; Wen, C.H.; Chu, A.K.

2010-01-01

Structures and surface chemical composition of indium tin oxide (ITO) thin films prepared by long-throw radio-frequency magnetron sputtering technique have been investigated. The ITO films were deposited on glass substrates using a 20 cm target-to-substrate distance in a pure argon sputtering environment. X-ray diffraction results showed that an increase in substrate temperature resulted in ITO structure evolution from amorphous to polycrystalline. Field-emission scanning electron microscopy micrographs suggested that the ITO films were free of bombardment of energetic particles since the microstructures of the films exhibited a smaller grain size and no sub-grain boundary could be observed. The surface composition of the ITO films was characterized by X-ray photoelectron spectroscopy (XPS). Oxygen atoms in both amorphous and crystalline ITO structures were observed from O 1 s XPS spectra. However, the peak of the oxygen atoms in amorphous ITO phase could only be found in samples prepared at low substrate temperatures. Its relative peak area decreased drastically when substrate temperatures were larger than 200 o C. In addition, a composition analysis from the XPS results revealed that the films deposited at low substrate temperatures contained high concentration of oxygen at the film surfaces. The oxygen-rich surfaces can be attributed to hydrolysis reactions of indium oxides, especially when large amount of the amorphous ITO were developed near the film surfaces.

Nuclear industry in a country with a substantial oil reserve

International Nuclear Information System (INIS)

Alvarez, R.; Castillo, H.; Costa, D.; Galan, I.; Martinez, M.

1981-01-01

The importance of the development of a nuclear industry in a country like Mexico, with a substantial oil reserve is analyzed, taking into account the technical, economical, political, ecological and social aspects of the problem. (author)

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to Lactobacillus johnsonii NCC 533 (La1) (CNCM I-1225) and improving immune defence against pathogenic gastro-intestinal microorganisms (ID 896), and protection, of the skin from UV-induced damage (ID 900) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

DEFF Research Database (Denmark)

Tetens, Inge

claims in relation to Lactobacillus johnsonii NCC 533 (La1) (CNCM I-1225) and improving immune defence against pathogenic gastro-intestinal microorganisms, and protection of the skin from UV-induced damage. The scientific substantiation is based on the information provided by the Member States...

20 CFR 416.972 - What we mean by substantial gainful activity.

Science.gov (United States)

2010-04-01

... INCOME FOR THE AGED, BLIND, AND DISABLED Determining Disability and Blindness Substantial Gainful... consider activities like taking care of yourself, household tasks, hobbies, therapy, school attendance...

EXPERIMENTAL SUBSTANTIATION OF ATTRIBUTIONAL STYLE IN TRAFFIC POLICE OFFICERS’ BEHAVIOR

Directory of Open Access Journals (Sweden)

Olga Vladimirovna Merkusheva

2016-02-01

Full Text Available The article prepared for the ‘Psychological and Methodological Aspects of Professional Personnel Training at Internal Affairs Bodies of the Russian Federation’ scholar tradition looks at the applied aspect of handling security issues by traffic police officers. It presents the results of empirical study of the employees’ psychological characteristics conducted to substantiate their attributional style, which determines the specific character as well as the qua-lity and reliability of traffic police officers’ performance. Traffic police officers’ attributional style of behavior is researched with the help of attributional cognitive techniques for hazard phenomena detection as well as social perception and attribution technique and is viewed as the most stable entity, which reflects the employee’s personal and professional focus.Goal: to provide empirical substantiation of attributional style in traffic police officers’ behavior as an integral personality characteristic that ensures timely detection of hazard phenomena.

I act, therefore I err: EEG correlates of success and failure in a virtual throwing game.

Science.gov (United States)

Yazmir, Boris; Reiner, Miriam

2017-12-01

What are the neural responses to success and failure in a throwing task? To answer this question, we compared Event Related Potentials (ERPs) correlated with success and failure during a highly-ecological-virtual game. Participants played a tennis-like game in an immersive 3D virtual world, against a computer player, by controlling a virtual tennis racket with a force feedback robotic arm. Results showed that success, i.e. hitting the target, and failure, by missing the target, evoked ERP's that differ by peak, latencies, scalp signal distributions, sLORETA source estimation, and time-frequency patterns. The success related grand averaged ERP at the Cz electrode, had two peaks - a negative peak at 244ms and a positive peak at 12ms, prior to the actual successful hit, suggesting a possible process of prediction of success. The grand averaged ERP correlated with failure at Cz, had two peaks, a negative peak at about 107ms and a positive peak at about 311ms post failure. These results suggest different top-down and bottom-up loops for success and failure, which seem to be rooted in the spatial arrangement of the virtual game. Although the latency of the latter is consistent with the error related potentials reported in the literature, the characteristic is unique to this specific error, and differ significantly from other error related potentials in the same environment. These results further provide a basis for EEG based assessment and prediction of user's successful or erroneous movements, and design of the feedback loop in EEG based Brain-Computer Interfaces. Copyright © 2017 Elsevier B.V. All rights reserved.

SUBSTANTIAL EXCEPTIONS AND (DELIMITATIONS OF THE POWERS OF THE JUDGES ON CIVIL PROCEDURAL LAW

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Igor Raatz

2017-08-01

Full Text Available This essay aims to unveil the role of the substantial exceptions on delimiting the powers of the judges on civil procedural law, especially regarding the ex officio judicial activity. This way, under a phenomenological method and based on a vision of guarantee of rights on procedural law, the article offers a brief explanation of the question concerning the content of the object under litigation and its role of (delimiting the powers of the judges. The work hypothesis is the addition of the substantial exceptions among the content of the object under litigation, along with the claim itself and the cause of action. The results lie on the premise that, by the substantial exceptions, the defendant extends the object under litigation – which is formed dynamically on civil procedure. The conclusion points towards the idea that the substantial exceptions act in a way of limiting the ex officio judicial activity on civil procedural law

Substantial increase in acceleration potential of pyroelectric crystals

International Nuclear Information System (INIS)

Tornow, W.; Lynam, S. M.; Shafroth, S. M.

2010-01-01

We report on a substantial increase in the acceleration potential achieved with a LiTaO 3 pyroelectric crystal. With a single 2.5 cm diameter and 2.5 cm long z-cut crystal without electric field-enhancing nanotip we produced positive ion beams with maximal energies between 300 and 310 keV during the cooling phase when the crystal was exposed to 5 mTorr of deuterium gas. These values are about a factor of 2 larger than previously obtained with single pyroelectric crystals.

RELIGIOUS DEMOCRATIZATION IN INDONESIA: STRENGTHENING THE PRO-CEDURAL AND SUBSTANTIAL RELIGIOUS DEMOCRACY

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Eka Hendry AR.

2013-06-01

Full Text Available Inspired by the book of Michael Mann about the dark side of democracy that discusses the paradox between the ideality of democratic values and empirical realities of violence in the name of freedom (democracy, this paper begins with the exposure of the paradox, such as the rise of the violent conflict between groups of people (both ethnic and religious-based and the high prevalence of violence between religious groups in Indonesia. Even worse, a very wrenching violence involves state actors (rulers. This paper tries to understand the roots of the paradox, with a look at how the relationship between state and religion and the religious community trend of Indonesia (especially Muslims. The author argues that the democratization of religion is a solution to the issues. To answer what kind of religious democracy lives in Indonesia, the author analyzes through a religious procedural (or constitutional democratic dimension and religious substantial democratic dimension. The phenomenon of disobedience of law and system and the euphoria of law-making that reflects “intolerance” in several places in Indonesia display the fundamental issue in the religious procedural democracy. Whereas in the context of religious substantial democracy, the prevailing trend of religion that serves as a political and economic vehicle and ignores religion as a substantial aspect of the behavior of the Indonesian society has resulted in the marginalization of religious position and function. Then, the infiltration of the model of political Islam has also led to alienation of the character of the Islamic society of Indonesia, from a democratic pattern to a revival (radical one. In this light, the author needs to present a strategy to encourage religious democracy in Indonesia, structurally through formulating the ideal relation model between state and religion and culturally through a substantial pattern of religion embedded with the character of Indonesian religious

25–34 GHz Single-Pole, Double-Throw CMOS Switches for a Ka-Band Phased-Array Transceiver

Directory of Open Access Journals (Sweden)

Sangyong Park

2018-01-01

Full Text Available This paper presents two single-pole, double-throw (SPDT mm-wave switches for Ka-band phased-array transceivers, fabricated with a 65-nm complementary metal oxide semiconductor (CMOS process. One switch employs cross-biasing (CB control with a single supply, while the other uses dual-supply biasing (DSB control with positive and negative voltages. Negative voltages were generated internally, using a ring oscillator and a charge pump. Identical gate and body floated N-type metal oxide semiconductor field effect transistors (N-MOSFETs in a triple well were used as the switch core transistors. Inductors were used to improve the isolation between the transmitter (TX and receiver (RX, as well as insertion loss, by canceling the parasitic capacitance of the switch core transistors at resonance. The size of the proposed radio frequency (RF switch is 260 μm × 230 μm, excluding all pads. The minimum insertion losses of the CB and DSB switches were 2.1 dB at 28 GHz and 1.93 dB at 24 GHz, respectively. Between 25 GHz and 34 GHz, the insertion losses were less than 2.3 dB and 2.5 dB, the return losses were less than 16.7 dB and 17.3 dB, and the isolation was over 18.4 dB and 15.3 dB, respectively. The third order input intercept points (IIP3 of the CB and DSB switches were 38.4 dBm and 39 dBm at 28 GHz, respectively.

The Effect of Cerebellar Transcranial Direct Current Stimulation on A Throwing Task Depends on Individual Level of Task Performance.

Science.gov (United States)

Mizuguchi, Nobuaki; Katayama, Takashi; Kanosue, Kazuyuki

2018-02-10

The effect of cerebellar transcranial direct current stimulation (tDCS) on motor performance remains controversial. Some studies suggest that the effect of tDCS depends upon task-difficulty and individual level of task performance. Here, we investigated whether the effect of cerebellar tDCS on the motor performance depends upon the individual's level of performance. Twenty-four naïve participants practiced dart throwing while receiving a 2-mA cerebellar tDCS for 20 min under three stimulus conditions (anodal-, cathodal-, and sham-tDCS) on separate days with a double-blind, counter-balanced cross-over design. Task performance was assessed by measuring the distance between the center of the bull's eye and the dart's position. Although task performance tended to improve throughout the practice under all stimulus conditions, improvement within a given day was not significant as compared to the first no-stimulus block. In addition, improvement did not differ among stimulation conditions. However, the magnitude of improvement was associated with an individual's level of task performance only under cathodal tDCS condition (p performance improvement only for the sub-group of participants with lower performance levels as compared to that with sham-tDCS (p task performance. Thus, cerebellar tDCS would facilitate learning of a complex motor skill task only in a subset of individuals. Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

Tocotrienols and Whey Protein Isolates Substantially Increase Exercise Endurance Capacity in Diet -Induced Obese Male Sprague-Dawley Rats

Science.gov (United States)

Aguila, Jay; McConell, Glenn K.; McAinch, Andrew J.; Mathai, Michael L.

2016-01-01

Background and Aims Obesity and impairments in metabolic health are associated with reductions in exercise capacity. Both whey protein isolates (WPIs) and vitamin E tocotrienols (TCTs) exert favorable effects on obesity-related metabolic parameters. This research sought to determine whether these supplements improved exercise capacity and increased glucose tolerance in diet-induced obese rats. Methods Six week old male rats (n = 35) weighing 187 ± 32g were allocated to either: Control (n = 9), TCT (n = 9), WPI (n = 8) or TCT + WPI (n = 9) and placed on a high-fat diet (40% of energy from fat) for 10 weeks. Animals received 50mg/kg body weight and 8% of total energy intake per day of TCTs and/or WPIs respectively. Food intake, body composition, glucose tolerance, insulin sensitivity, exercise capacity, skeletal muscle glycogen content and oxidative enzyme activity were determined. Results Both TCT and WPI groups ran >50% longer (2271 ± 185m and 2195 ± 265m respectively) than the Control group (1428 ± 139m) during the run to exhaustion test (Pexercise endurance (2068 ± 104m). WPIs increased the maximum in vitro activity of beta-hydroxyacyl-CoA in the soleus muscle (Pexercise endurance by 50% in sedentary, diet-induced obese rats. These positive effects of TCTs and WPIs were independent of body weight, adiposity or glucose tolerance. PMID:27058737

Paracetamol: overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro.

Science.gov (United States)

Wang, Xu; Wu, Qinghua; Liu, Aimei; Anadón, Arturo; Rodríguez, José-Luis; Martínez-Larrañaga, María-Rosa; Yuan, Zonghui; Martínez, María-Aránzazu

2017-11-01

Paracetamol (APAP) is one of the most widely used and popular over-the-counter analgesic and antipyretic drugs in the world when used at therapeutic doses. APAP overdose can cause severe liver injury, liver necrosis and kidney damage in human beings and animals. Many studies indicate that oxidative stress is involved in the various toxicities associated with APAP, and various antioxidants were evaluated to investigate their protective roles against APAP-induced liver and kidney toxicities. To date, almost no review has addressed the APAP toxicity in relation to oxidative stress. This review updates the research conducted over the past decades into the production of reactive oxygen species (ROS), reactive nitrogen species (RNS), and oxidative stress as a result of APAP treatments, and ultimately their correlation with the toxicity and metabolism of APAP. The metabolism of APAP involves various CYP450 enzymes, through which oxidative stress might occur, and such metabolic factors are reviewed within. The therapeutics of a variety of compounds against APAP-induced organ damage based on their anti-oxidative effects is also discussed, in order to further understand the role of oxidative stress in APAP-induced toxicity. This review will throw new light on the critical roles of oxidative stress in APAP-induced toxicity, as well as on the contradictions and blind spots that still exist in the understanding of APAP toxicity, the cellular effects in terms of organ injury and cell signaling pathways, and finally strategies to help remedy such against oxidative damage.

Application of interdisciplinary connections and information technologies for development of motor skills in light athletic of girls - senior form pupils

Directory of Open Access Journals (Sweden)

Abdel Baset Al-Ravashdeh

2015-08-01

Full Text Available Purpose: to work out and substantiate technologies of motor and intellectual aspects’ integral impact on process of training of light athletic’ throws and run techniques of 15-16 years old girls. Material: in the research 2 groups of pupils participated: control group (n = 22 and experimental group (n = 21. Results: Methodic of run, jumps and throws techniques’ training of senior school girl-pupils has been worked out. The methodic implies mastering of basic light athletic movements on the base of analogies with rational and economic movements in animate nature and laws of mechanic It conditions application of knowledge from physics, biology, mathematic for receiving of more complete understanding of light athletic movements’ correct technique. Conclusions: we have shown that application of interdisciplinary connections permits to make the process of movements’ training more effective in comparison with mastering material of purely physical education.

Substantiating the Incurred but not Reported Reserve

Directory of Open Access Journals (Sweden)

Georgeta Vintilã

2009-12-01

Full Text Available In order to handle past and future liability taken by insurance contracts concluded, any insurance company must constitute and maintain technical reserves. Substantiating technical reserves is done through actuarial methods and its over-evaluation or under-evaluation influence solvency and financial performance of the insurance companies, in the sense of reducing solvency through over-evaluating reserves and, respectively, influencing profit (hence of outstanding tax through under-evaluating reserves. An important reserve for insurance companies is represented by the incurred but not reported reserve, as it allows the estimation of the liability the company may confront in the future, generated by events occurred in the past, which are not currently known in the present but will be reported in the future.

26 CFR 1.6662-4 - Substantial understatement of income tax.

Science.gov (United States)

2010-04-01

... arrangement does not have as its principal purpose the avoidance or evasion of Federal income tax solely as a... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Substantial understatement of income tax. 1... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Additions to the Tax, Additional Amounts, and Assessable...

Training with anxiety has a positive effect on expert perceptual-motor performance under pressure

NARCIS (Netherlands)

Oudejans, R.R.D.; Pijpers, J.R.

2009-01-01

In two experiments, we examined whether training with anxiety can prevent choking in experts performing perceptual-motor tasks. In Experiment 1, 17 expert basketball players practised free throws over a 5-week period with or without induced anxiety. Only after training with anxiety did performance

40 CFR Appendix C to Part 112 - Substantial Harm Criteria

Science.gov (United States)

2010-07-01

... to Part 112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Pt. 112, App. C Appendix C to Part 112—Substantial Harm Criteria 1.0Introduction The..., except in the Gulf of Mexico. In the Gulf of Mexico, it means the area shoreward of the lines of...

20 CFR 416.1080 - Notice of right to hearing on proposed finding of substantial failure.

Science.gov (United States)

2010-04-01

... agency has substantially failed to meet our standards unless the State submits a written request for a... finding of substantial failure. 416.1080 Section 416.1080 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Determinations of Disability...

TECHNICAL AND ECONOMIC SUBSTANTIATION OF PROJECTS OF THE AFFORDABLE HOUSING CONSTRUCTION

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KRAVCHUNOVSKA T. S.

2015-12-01

Full Text Available Summary. Problem statement. The development of inhabitant locality of Ukraine is characterized by significant differences in levels of socio and economic development. An excessive concentration of population and industry in large cities, inefficient, slow development of most medium and small cities, towns and villages, considerable territorial disproportions of economic development of the country, considerable shortcomings in the territorial organization of society are observed. At the same time the tendency of the total area of increasing of inhabitant locality. The lands are used inefficiently. Among the most common problems of inhabitant locality is the housing problem. When making a decision on the design of affordable housing construction is one of the most important stages in the development of the technique and economic substantiation of the project is determination of the advisability and effectiveness of construction. The substantiation of advisability and effectiveness of affordable housing based on the definition of technical and economic indicators of projects, one of the most important among them is the cost, in its calculation is necessary to take into account the influence of organizational and technological factors, reflecting the features of construction in condition of compacted construction. Purpose. Development of methodical recommendations on substantiation of cost construction of affordable housing in the conditions of compacted construction. Conclusion. To provide a processing and the analysis of data is necessary development of the applied software on the basis of the developed block scheme of justification of cost construction of affordable housing.

Pharmacogenomic Prediction of Anthracycline-Induced Cardiotoxicity in Children

NARCIS (Netherlands)

Visscher, Henk; Ross, Colin J. D.; Rassekh, S. Rod; Barhdadi, Amina; Dubé, Marie-Pierre; Al-Saloos, Hesham; Sandor, George S.; Caron, Huib N.; van Dalen, Elvira C.; Kremer, Leontien C.; van der Pal, Helena J.; Brown, Andrew M. K.; Rogers, Paul C.; Phillips, Michael S.; Rieder, Michael J.; Carleton, Bruce C.; Hayden, Michael R.; Dube, Marie-Pierre

2012-01-01

Purpose Anthracycline-induced cardiotoxicity (ACT) is a serious adverse drug reaction limiting anthracycline use and causing substantial morbidity and mortality. Our aim was to identify genetic variants associated with ACT in patients treated for childhood cancer. Patients and Methods We carried out

Substantiation of the road toll for heavy transport vehicles

OpenAIRE

Burmaka, N.; Chernykh, A.

2010-01-01

The existing and possible additional sources of developing state and local road funds of Ukraine have been considered. The formula for calculating monthly road toll for heavy transport vehicles has been proposed. This formula includes the payment rate per every kilometer of distance, the vehicle capacity utilization factor and the run with the load. The payment rate per every kilometer of distance for transport vehicles depending on the allowed total weight has been substantiated. The given r...

20 CFR 404.1680 - Notice of right to hearing on proposed finding of substantial failure.

Science.gov (United States)

2010-04-01

... agency has substantially failed to meet our standards unless the State submits a written request for a... finding of substantial failure. 404.1680 Section 404.1680 Employees' Benefits SOCIAL SECURITY..., following the mandatory performance support period and the 3-month adjustment period, a State agency again...

Reliability and responsiveness of a goniometric device for measuring the range of motion in the dart-throwing motion plane.

Science.gov (United States)

Kasubuchi, Kenji; Dohi, Yoshihiro; Fujita, Hiroyuki; Fukumoto, Takahiko

2018-02-26

Dart-throwing motion (DTM) is an important component of wrist function and, consequently, has the potential to become an evaluation tool in rehabilitation. However, no measurement method is currently available to reliably measure range of motion (ROM) of the wrist in the DTM plane. To determine the reliability and responsiveness of a goniometric device to measure wrist ROM in the DTM plane. ROM of the wrist in the DTM plane was measured in 70 healthy participants. The intra-class correlation coefficient (ICC) was used to evaluate the relative reliability of measurement, and a Bland-Altman analysis conducted to establish its absolute reliability, including the 95% limits of agreement (95% LOA). The standard error of the measurement (SEM) and minimal detectable change at the 95% confidence level (MDC 95 ) were calculated as measures of responsiveness. The intra-rater ICC was 0.87, and an inter-rater ICC of 0.71. There was no evidence of a fixed or proportional bias. For intra- and inter-rater reliability, 95% LOA ranged from -13.83 to 11.12 and from -17.75 to 16.19, respectively. The SEM and MDC 95 were 4.5° and 12.4°, respectively, for intra-rater reliability, and 6.0° and 16.6°, respectively, for inter-rater reliability. The ROM of the wrist in the DTM plane was measured with fair-to-good reliability and responsiveness and, therefore, has the potential to become an evaluation tool for rehabilitation.

75 FR 27504 - Substantial Product Hazard List: Hand-Held Hair Dryers

Science.gov (United States)

2010-05-17

... immersion during their use. Section 15(a) of the CPSA defines ``substantial product hazard'' to include, a....'' Hand-held hair dryers routinely contain open-coil heating elements that are, in essence, uninsulated..., bathtub, or lavatory). The proposed rule would define ``hand-held hair dryer'' as ``an electrical...

Achievement goals, self-handicapping, and performance: a 2 x 2 achievement goal perspective.

Science.gov (United States)

Ntoumanis, Nikos; Thøgersen-Ntoumani, Cecilie; Smith, Alison L

2009-11-01

Elliot and colleagues (2006) examined the effects of experimentally induced achievement goals, proposed by the trichotomous model, on self-handicapping and performance in physical education. Our study replicated and extended the work of Elliot et al. by experimentally promoting all four goals proposed by the 2 x 2 model (Elliot & McGregor, 2001), measuring the participants' own situational achievement goals, using a relatively novel task, and testing the participants in a group setting. We used a randomized experimental design with four conditions that aimed to induce one of the four goals advanced by the 2 x 2 model. The participants (n = 138) were undergraduates who engaged in a dart-throwing task. The results pertaining to self-handicapping partly replicated Elliot and colleagues' findings by showing that experimentally promoted performance-avoidance goals resulted in less practice. In contrast, the promotion of mastery-avoidance goals did not result in less practice compared with either of the approach goals. Dart-throwing performance did not differ among the four goal conditions. Personal achievement goals did not moderate the effects of experimentally induced goals on self-handicapping and performance. The extent to which mastery-avoidance goals are maladaptive is discussed, as well as the interplay between personal and experimentally induced goals.

75 FR 64683 - Liability for Termination of Single-Employer Plans; Treatment of Substantial Cessation of Operations

Science.gov (United States)

2010-10-20

... Termination of Single-Employer Plans; Treatment of Substantial Cessation of Operations AGENCY: Pension Benefit... cessations of operations by employers that maintain single-employer plans. DATES: Comments must be submitted... 4062(e), which provides for reporting of and liability for certain substantial cessations of operations...

Morphological substantiation for acute immobilization stress-related disorders of adaptation mechanisms.

Science.gov (United States)

Koptev, Mykhailo M; Vynnyk, Nataliia I

Nowadays, an individual is being constantly accompanied by stresses in his/her everyday life. Stress reactions, produced in the process of evolution, have become the organisms' response to emergency action or pathological factors and are the important link in adaptation process. However, the adverse course of stress reaction can lead to derangement of the adaptation mechanisms in the body and become the element of the pathogenesis of various diseases. The study was aimed at morphological substantiation of derangement of adaptation mechanisms in white Wistar rats caused by the acute immobilization stress. 40 Wistar white male rats of 240-260 g body weight aged 8-10 months were involved into study. 20 laboratory animals were assigned to the main group and the rest 20 rats formed the control (II) group. Experimental stress model was simulated by immobilization of rats, lying supine, for 6 hours. Morphological examination of heart, lungs and kidneys was carried out after animals' decapitation, which proved the derangement of rats' adaptation mechanisms caused by the acute immobilization stress. It has been established that six-hour immobility of rats, lying in the supine position, led to the development of destructive phenomena, hemorrhagic lesions and impaired hemomicrocirculation. Microscopically, the acute immobilization stress causes significant subendocardial hemorrhages, plethora of vessels of hemomicrocirculatory flow with dysdiemorrhysis, myocardial intersticium edema in the heart. Histologically, immobilization-induced trauma causes significant hemodynamic disorders, spasm of arterioles and considerable venous hyperemia, concomitant with microthrombosis in kidneys; at the same time dystrophic lesions and desquamation of epithelium of renal tubules has been observed in renal corpuscles. The abovementioned structural changes can contribute to origination and development of multiple lesions, demonstrating the morphologically grounded role of the acute

Free-throw accuracy and success as a function of ball weight in 9- to 11-year-old male players Precisão e êxito em função do peso da bola em jogadores de 9 a 11 anos de idade

Directory of Open Access Journals (Sweden)

José Luis Arias

2012-06-01

Full Text Available The goal of this study was to analyze whether 9-11 years old children can attain more free-throw accuracy and success by modifying the ball weight in basketball game. The participants were 54 children (age: mean=10.63, SD=0.55 years from six basketball teams. The participants played four games with each of the following balls: (a standard ball weight (485 g, 69-71 cm, (b a lighter ball (440 g, 69-71 cm, and (c a heavier ball (540 g, 69-71 cm. The procedures adopted in the study were: (a defining the variables, (b instructing the observers and obtaining reliability, (c monitoring the properties of the ball and filming the games, and (d recording the data from the observation. The results revealed statistically significant differences for free-throw accuracy (χ²=1.76, df=2, p=.050 and success (χ²=5.69, df=2, p=.048. Free-throw accuracy and success were higher with the 440-g ball than with the 540-g ball.O objetivo deste estudo foi analisar se crianças de 9 a 11 anos poderiam alcançar maior precisão e êxito no lance livre em função de diferentes pesos da bola no basquetebol. Participaram do presente estudo 54 crianças (idade: M=10.63, SD=0.55 de seis equipes de basquetebol. Os participantes jogaram quatro jogos com cada um das seguintes bolas: (a bola regulamentar (485 g, 69-71 cm, (b bola menos pesada (440 g, 69-71 cm, e (c bola mais pesada (540 g, 69-71 cm. Os procedimentos seguidos foram: (a definição das variáveis, (b formação dos observadores e obtenção da confiabilidade, (c controle das propriedades da bola e filmagem dos jogos, e (d gravação dos dados de observação. Os resultados revelaram diferenças estatísticas significativas para precisão (χ²=1,76; df=2; p=0,05 e êxito do lance livre (χ²=5,69; df=2; p=0,048. A precisão e êxito do lance livre foram mais elevados com a bola de 440 g em comparação com a bola de 540 g.

The rare earth element (REE) lanthanum (La) induces hormesis in plants.

Science.gov (United States)

Agathokleous, Evgenios; Kitao, Mitsutoshi; Calabrese, Edward J

2018-07-01

Lanthanum is a rare earth element (REE) which has been extensively studied due to its wide application in numerous fields with a potential accumulation in the environment. It has long been known for its potential to stimulate plant growth within a hormetic-biphasic dose response framework. This article provides evidence from a series of high resolution studies published within the last two decades demonstrating a substantial and significant occurrence of lanthanum-induced hormesis in plants. These findings suggest that hormetic responses should be built into the study design of hazard assessment study protocols and included in the risk assessment process. Hormesis also offers the opportunity to substantially improve cost benefit estimates for environmental contaminants, which have the potential to induce beneficial/desirable effects at low doses. Copyright © 2018 Elsevier Ltd. All rights reserved.

CDM criticisms: don't throw the baby out with the bathwater

Energy Technology Data Exchange (ETDEWEB)

Buen, Joerund

2012-07-01

CDM has delivered greater offset volumes than anticipated, mainly with money from the private sector in host countries (underlying project investment) and investor countries (carbon offset purchasing) and has built considerable institutional capacity. Criticisms have focused on high transaction costs and lack of scalability; additionality challenges and lack of net mitigation impact; preventing more ambitious targets and changes in emissions paths in developed and developing countries alike; excessive rents and perverse incentives; unbalanced regional distribution; low local sustainable development benefits; corruption and lack of transparency; and lack of technology transfer. While some of these criticisms are justified, others are outdated. Transaction costs have been drastically reduced. Excessive rents and perverse incentives in the CDM will be substantially reduced post-2012. Unbalanced regional distribution will be reduced by new rules; moreover, this is probably less of a problem than commonly thought. Some criticisms are erroneously founded. There is no evidence of CDM preventing more ambitious targets in developing countries while it could prevent changes in emissions paths in developed countries. Few CDM projects have serious known problems as regards sustainable development. Corruption and fraud seem limited; and technology transfer has never been a core CDM concern. Ironically, critics often neglect the elements that need to be improved. To ensure additionality, CDM rules must be tightened to exclude common practice projects and prevent host countries from changing their policies to cater for CDM projects. CDM's scalability and additionality challenges could be substantially reduced by discounting emission reductions. There could still be some non-additional projects, but the volume of the overall portfolio of projects would be additional.(Author)

Neuromuscular adaptations induced by adjacent joint training.

Science.gov (United States)

Ema, R; Saito, I; Akagi, R

2018-03-01

Effects of resistance training are well known to be specific to tasks that are involved during training. However, it remains unclear whether neuromuscular adaptations are induced after adjacent joint training. This study examined the effects of hip flexion training on maximal and explosive knee extension strength and neuromuscular performance of the rectus femoris (RF, hip flexor, and knee extensor) compared with the effects of knee extension training. Thirty-seven untrained young men were randomly assigned to hip flexion training, knee extension training, or a control group. Participants in the training groups completed 4 weeks of isometric hip flexion or knee extension training. Standardized differences in the mean change between the training groups and control group were interpreted as an effect size, and the substantial effect was assumed to be ≥0.20 of the between-participant standard deviation at baseline. Both types of training resulted in substantial increases in maximal (hip flexion training group: 6.2% ± 10.1%, effect size = 0.25; knee extension training group: 20.8% ± 9.9%, effect size = 1.11) and explosive isometric knee extension torques and muscle thickness of the RF in the proximal and distal regions. Improvements in strength were accompanied by substantial enhancements in voluntary activation, which was determined using the twitch interpolation technique and RF activation. Differences in training effects on explosive torques and neural variables between the two training groups were trivial. Our findings indicate that hip flexion training results in substantial neuromuscular adaptations during knee extensions similar to those induced by knee extension training. © 2017 The Authors. Scandinavian Journal of Medicine & Science In Sports Published by John Wiley & Sons Ltd.

Rumination impairs the control of stimulus-induced retrieval of irrelevant information, but not attention, control, or response selection in general.

Science.gov (United States)

Colzato, Lorenza S; Steenbergen, Laura; Hommel, Bernhard

2018-01-23

The aim of the study was to throw more light on the relationship between rumination and cognitive-control processes. Seventy-eight adults were assessed with respect to rumination tendencies by means of the LEIDS-r before performing a Stroop task, an event-file task assessing the automatic retrieval of irrelevant information, an attentional set-shifting task, and the Attentional Network Task, which provided scores for alerting, orienting, and executive control functioning. The size of the Stroop effect and irrelevant retrieval in the event-five task were positively correlated with the tendency to ruminate, while all other scores did not correlate with any rumination scale. Controlling for depressive tendencies eliminated the Stroop-related finding (an observation that may account for previous failures to replicate), but not the event-file finding. Taken altogether, our results suggest that rumination does not affect attention, executive control, or response selection in general, but rather selectively impairs the control of stimulus-induced retrieval of irrelevant information.

Left-liver hypertrophy after therapeutic right-liver radioembolization is substantial but less than after portal vein embolization.

Science.gov (United States)

Garlipp, Benjamin; de Baere, Thierry; Damm, Robert; Irmscher, Romy; van Buskirk, Mark; Stübs, Patrick; Deschamps, Frederic; Meyer, Frank; Seidensticker, Ricarda; Mohnike, Konrad; Pech, Maciej; Amthauer, Holger; Lippert, Hans; Ricke, Jens; Seidensticker, Max

2014-05-01

In patients with liver malignancies potentially amenable to curative extended right hepatectomy but insufficient size of the future liver remnant (FLR), portal vein embolization (PVE) of the tumor-bearing liver is used to induce contralateral liver hypertrophy but leaves the tumor untreated. Radioembolization (RE) treats the tumor in the embolized lobe along with contralateral hypertrophy induction. We performed a matched-pair analysis to compare the capacity for hypertrophy induction of these two modalities. Patients with right-hepatic secondary liver malignancies with no or negligible left-hepatic tumor involvement who were treated by right-lobar PVE (n = 141) or RE (n = 35) at two centers were matched for criteria known to influence liver regeneration following PVE: 1) baseline FLR/Total liver volume ratio (<25 versus ≥ 25%); 2) prior platinum-containing systemic chemotherapy; 3) embolization of segments 5-8 versus 4-8; and 4) baseline platelet count (<200 versus ≥ 200 Gpt/L).The primary endpoint was relative change in FLR volume from baseline to follow-up. Twenty-six matched pairs were identified. FLR volume increase from baseline to follow-up (median 33 [24-56] days after PVE or 46 [27-79] days after RE) was significant in both groups but PVE produced significantly more FLR hypertrophy than RE (61.5 versus 29%, P < 0.001). Time between treatment and follow-up was not correlated with the degree of contralateral hypertrophy achieved in both groups. Although group differences in patient history and treatment setting were present and some bias cannot be excluded, this was minimized by the matched-pair design, as remaining group differences after matching were found to have no significant influence on contralateral hypertrophy development. PVE induces significantly more contralateral hypertrophy than RE with therapeutic (nonlobectomy) doses. However, contralateral hypertrophy induced by RE is substantial and RE minimizes the risk of tumor progression in the

Do substantial BMI reduction episodes among Swedish schoolchildren have any impact on their final height?

Science.gov (United States)

Nilsen, Bente B; Yngve, Agneta; Werner, Bo

2018-02-06

This study investigated whether substantial body mass index (BMI) reductions in Swedish schoolchildren aged seven years to 19 years, caused by disease, healthy or unhealthy behaviour, had any impact on their final height. We used height and weight data on 6572 subjects from two nationally representative longitudinal samples of Swedish children born in 1973 and 1981. These provided information on their final height and any BMI reduction episodes. Of the 6572 subjects (50.9% boys), among individuals with information on final height, 1118 had a BMI reduction of 5% and BMI reduction of 10% or more. On a group level, there was no statistically significant difference in the final height of individuals with BMI reductions of 10% or more and those without. The findings were independent of age and the subject's BMI at the start of the reduction episode. However, there were a number of cases where a substantial BMI reduction probably had an impact on the subject's final height. Our study found no evidence that a substantial BMI reduction had any impact on final height on a group level, but further analyses of specific case studies are necessary to determine whether substantial BMI reduction might have an impact on final height. ©2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

A review on stray current-induced steel corrosion in infrastructure

NARCIS (Netherlands)

Chen, Zhipei; Koleva, D.A.; van Breugel, K.

2017-01-01

Metallic corrosion can cause substantial damage at various levels and in almost all types of infrastructure. For metallic corrosion to occur, a certain external environment and the presence of corrodents are the prerequisites. Stray current-induced corrosion, however, is a rather underestimated

Efeitos do posicionamento e quantidade de prática mental na aprendizagem do arremesso do dardo de salão Effects of position and amount of mental practice in dart saloon throwing learning

Directory of Open Access Journals (Sweden)

Thábata Viviane Brandão Gomes

2012-06-01

Full Text Available A prática mental parece contribuir no processo de aprendizagem motora, mas ainda não estão claros os efeitos do posicionamento e da quantidade de prática mental em relação à prática física, sendo este o objetivo do presente estudo. Setenta e dois universitários de ambos os sexos e novatos na tarefa foram distribuídos em seis grupos de prática combinada (física e mental para a aprendizagem do arremesso do dardo de salão. Na fase de aquisição, os sujeitos realizaram 50 tentativas de prática física e 18, 90 ou 180 tentativas de prática mental (conforme cada grupo antes ou após a prática física. Dez minutos após a fase de aquisição foram realizados os testes de retenção e transferência. Não foi observada diferença significante entre os grupos nos testes. Os resultados indicaram que a quantidade e o posicionamento da prática mental não influenciaram a aprendizagem do arremesso do dardo de salão.Mental practice seems to contribute to the motor learning process but it is still not clear the effects of position and amount of mental practice in relation to physical practice, which was the aim of this study. Seventy two undergraduate students of both sexes and novice in the task were assigned in six groups of combined practice (physical and mental for learning the dart saloon throwing. In acquisition phase, subjects performed 50 trials of physical practice and 18, 90 or 180 trials of mental practice (according to each experimental group before or after physical practice. Ten minutes after acquisition phase it was performed retention and transfer tests. The results showed that amount and the position of mental practice did not influence dart saloon throwing learning.

COMPOSITIONAL AND SUBSTANTIAL STRUCTURE OF THE MEDICAL DOCUMENT: FORMATION STAGES

Directory of Open Access Journals (Sweden)

Romashova Olga Vladimirovna

2015-03-01

Full Text Available The article deals with the compositional and substantial structure of the ambulatory medical record, or "case history", which has being formed for a long time. The author allocates the three main periods in the formation of this medical document: the first period (the beginning of the 19th century – 1920s is connected with the origin and formation; the second period (1920-1980s is marked by emergence of the normative legal acts regulating registration and maintaining; the third period (1980s – up to the present is associated with the cancellation of regulations and the introduction of the new order of the Ministry of Health of the USSR that changed the document's form and name. It is determined that the composition of the case history consists of the title page and the main part. The following processes take place in the course of ambulatory medical record's formation: strengthening formalization, increase in the number of pattern text fragments, increase in the text's volume, and the implementation of bigger number of functions. The author reveals the main (informative and cumulative, accounting and additional (scientific, controlling, legal, financial functions of the document. The implementation of these functions is reflected in the compositional and substantial structure of the document text and is conditioned by a number of extralinguistic factors.

Induced seismicity in geothermal reservoirs : A review of forecasting approaches

NARCIS (Netherlands)

Gaucher, Emmanuel; Schoenball, Martin; Heidbach, Oliver; Zang, Arno; Fokker, Peter A.; Van Wees, Jan Diederik; Kohl, Thomas

2015-01-01

In order to reach Europes 2020 and 2050 targets in terms of greenhouse gas emissions, geothermal resources will have to contribute substantially to meeting carbon-free energy needs. However, public opinion may prevent future large-scale application of deep geothermal power plants, because induced

Induced seismicity in geothermal reservoirs: A review of forecasting approaches

NARCIS (Netherlands)

Gaucher, E.; Schoenball, M.; Heidbach, O.; Zang, A.; Fokker, P.A.; Wees, J.D. van; Kohl, T.

2015-01-01

In order to reach Europes 2020 and 2050 targets in terms of greenhouse gas emissions, geothermal resources will have to contribute substantially to meeting carbon-free energy needs. However, public opinion may prevent future large-scale application of deep geothermal power plants, because induced

Dopamine receptors genes polymorphisms in Parkinson patients with levodopa-induced dyskinesia

NARCIS (Netherlands)

Pozhidaev, I.; Alifirova, V.M.; Freidin, M.B.; Zhukova, I.A.; Fedorenko, O.Y.; Osmanova, D.Z.; Mironova, Y.S.; Wilffert, B.; Ivanova, S.A.; Loonen, A.J.M.

2017-01-01

Introduction: Long-term levodopa treatment of Parkinson's disease (PD) is frequently complicated by spontaneously occur ring involuntary muscle movements called levodopa-induced dyskinesia (LID). LID are a substantial barrier to effective symptomatic management of Parkinson's disease (PD), as up to

Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin

NARCIS (Netherlands)

Middelkamp-Hup, Maritza A.; Pathak, Madhu A.; Parrado, Concepcion; Goukassian, David; Rius-Díaz, Francisca; Mihm, Martín C.; Fitzpatrick, Thomas B.; González, Salvador

2004-01-01

BACKGROUND: UV radiation induces damage to human skin. Protection of skin by an oral photoprotective agent would have substantial benefits. Objective We investigated the photoprotective effect of oral administration of an extract of the natural antioxidant Polypodium leucotomos (PL). METHODS: A

76 FR 32215 - Agency Information Collection Activities; Proposed Collection; Comment Request; Substantiation...

Science.gov (United States)

2011-06-03

... of such disease in the United States [(U.S.)], describes the role of a nutrient or dietary ingredient... substantiation for their claims in the scientific literature. The time it takes to assemble the necessary... based on emerging science, where conducting literature searches and understanding the literature takes...

CT-based three-dimensional kinematic comparison of dart-throwing motion between wrists with malunited distal radius and contralateral normal wrists

International Nuclear Information System (INIS)

Lee, S.; Kim, Y.S.; Park, C.S.; Kim, K.G.; Lee, Y.H.; Gong, H.S.; Lee, H.J.; Baek, G.H.

2014-01-01

Aim: To compare motion of the capitate, scaphoid, and lunate in wrists with a malunited distal radius and contralateral normal wrists during dart-throwing motion (DTM) by three-dimensional kinematic studies using computed tomography (CT) images. Materials and methods: CT was performed simultaneously on both wrists in six patients with a unilateral distal radius malunion at three stepwise positions simulating DTM. Using volume registration technique, the kinematic variables of helical axis motion of the capitate, scaphoid, and lunate were calculated and compared between both wrists. The helical motion of the capitate was also evaluated in a scaphoid- and lunate-based coordinate system. Results: Among the average rotation and translation of the scaphoid, lunate, and capitate during DTM, only the average rotation of the capitate was significantly different between the uninjured (88.9°) and the injured (70°) wrist (p = 0.0075). Rotation of the capitate relative to the scaphoid (26.3° versus 37.8°, p = 0.029) or lunate (39.2° versus 59.3°, p = 0.028) was smaller in the malunited wrist. The centres of helical axis motion of the three carpal bones were located more dorsally and radially in the injured wrist. Conclusions: The present study showed that decreased DTM in wrists with a distal radius malunion resulted from decreased midcarpal motion. The present study of the capitate, scaphoid, and lunate in wrists with distal radius malunion might be the first to present a 3D kinematic analysis of the effect of distal radius malunion on the carpal bones

Fulltext PDF

Indian Academy of Sciences (India)

Susheel Dharmadhikari

2018-03-10

Mar 10, 2018 ... studied neurological adaptations related to throwing and noted differences in brains of chimpanzees that correlated with variations in their throwing ability. It is thus clear that anatomy and biomechanics play critical roles in human throwing, and the ability to throw fast has evolved over time. There are also ...

21 CFR 101.43 - Substantial compliance of food retailers with the guidelines for the voluntary nutrition labeling...

Science.gov (United States)

2010-04-01

... FOR HUMAN CONSUMPTION FOOD LABELING Specific Nutrition Labeling Requirements and Guidelines § 101.43 Substantial compliance of food retailers with the guidelines for the voluntary nutrition labeling of raw fruit... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Substantial compliance of food retailers with the...

Substantial injuries influence ranking position in young elite athletes of athletics, cross-country skiing and orienteering.

Science.gov (United States)

von Rosen, P; Heijne, A

2018-04-01

The relationship between injury and performance in young athletes is scarcely studied. The aim of this study was therefore to explore the association between injury prevalence and ranking position among adolescent elite athletes. One hundred and sixty-two male and female adolescent elite athletes (age range 15-19), competing in athletics (n = 59), cross-country skiing (n = 66), and orienteering (n = 37), were monitored weekly over 22-47 weeks using a web-based injury questionnaire. Ranking lists were collected. A significant (P = .003) difference was found in the seasonal substantial injury prevalence across the ranked athletes over the season, where the top-ranked (median 3.6%, 25-75th percentiles 0%-14.3%) and middle-ranked athletes (median 2.3%, 25-75th percentiles 0%-10.0%) had a lower substantial injury prevalence compared to the low-ranked athletes (median 11.3%, 25-75th percentiles 2.5%-27.1%), during both preseason (P = .002) and competitive season (P = .031). Athletes who improved their ranking position (51%, n = 51) reported a lower substantial injury prevalence (median 0%, 25-75th percentiles 0%-10.0%) compared to those who decreased (49%, n = 49) their ranking position (md 6.7%, 25-75th percentiles 0%-22.5%). In the top-ranked group, no athlete reported substantial injury more than 40% of all data collection time points compared to 9.6% (n = 5) in the middle-ranked, and 17.3% (n = 9) in the low-ranked group. Our results provide supporting evidence that substantial injuries, such as acute and overuse injuries leading to moderate or severe reductions in training or sports performance, influence ranking position in adolescent elite athletes. The findings are crucial to stakeholders involved in adolescent elite sports and support the value of designing effective preventive interventions for substantial injuries. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Neighborhood-level social processes and substantiated cases of child maltreatment.

Science.gov (United States)

Molnar, Beth E; Goerge, Robert M; Gilsanz, Paola; Hill, Andrea; Subramanian, S V; Holton, John K; Duncan, Dustin T; Beatriz, Elizabeth D; Beardslee, William R

2016-01-01

Child maltreatment is a preventable public health problem. Research has demonstrated that neighborhood structural factors (e.g. poverty, crime) can influence the proportion of a neighborhood's children who are victims of maltreatment. A newer strategy is the identification of potentially modifiable social processes at the neighborhood level that can also influence maltreatment. Toward this end, this study examines neighborhood-level data (maltreatment cases substantiated by Illinois' child protection agency, 1995-2005, social processes measured by the Project on Human Development in Chicago Neighborhoods, U.S. Census data, proportions of neighborhoods on public assistance, and crime data) that were linked across clusters of contiguous, relatively homogenous Chicago, IL census tracts with respect to racial/ethnic and socioeconomic composition. Our analysis-an ecological-level, repeated cross-sectional design utilizing random-intercept logit models-with a sensitivity analysis using spatial models to control for spatial autocorrelation-revealed consistent associations between neighborhood social processes and maltreatment. Neighborhoods higher in collective efficacy, intergenerational closure, and social networks, and lower in disorder had lower proportions of neglect, physical abuse, and sexual abuse substantiated cases, controlling for differences in structural factors. Higher collective efficacy and social network size also predicted a lower proportion of substance-exposed infants. This research indicates that strategies to mobilize neighborhood-level protective factors may decrease child maltreatment more effectively than individual and family-focused efforts alone. Copyright © 2015 Elsevier Ltd. All rights reserved.

Visual Illusions and the Control of Ball Placement in Goal-Directed Hitting

Science.gov (United States)

Caljouw, Simone R.; Van der Kamp, John; Savelsbergh, Geert J. P.

2010-01-01

When hitting, kicking, or throwing balls at targets, online control in the target area is impossible. We assumed this lack of late corrections in the target area would induce an effect of a single-winged Muller-Lyer illusion on ball placement. After extensive practice in hitting balls to different landing locations, participants (N = 9) had to hit…

Substantial Churn In Health Insurance Offerings By Small Employers, 2014-15.

Science.gov (United States)

Vistnes, Jessica P; Rohde, Frederick; Miller, G Edward; Cooper, Philip F

2017-09-01

New data for 2014-15 from the Medical Expenditure Panel Survey-Insurance Component longitudinal survey show substantial churn in insurance offers by small employers (those with fifty or fewer workers), with 14.6 percent of employers that offered insurance in 2014 having dropped it in 2015 and 5.5 percent of those that did not offer it adding coverage. Project HOPE—The People-to-People Health Foundation, Inc.

Holi colours contain PM10 and can induce pro-inflammatory responses

OpenAIRE

Bossmann, Katrin; Bach, Sabine; H?flich, Conny; Valtanen, Kerttu; Heinze, Rita; Neumann, Anett; Straff, Wolfgang; S?ring, Katrin

2016-01-01

Background At Holi festivals, originally celebrated in India but more recently all over the world, people throw coloured powder (Holi powder, Holi colour, Gulal powder) at each other. Adverse health effects, i.e. skin and ocular irritations as well as respiratory problems may be the consequences. The aim of this study was to uncover some of the underlying mechanisms. Methods We analysed four different Holi colours regarding particle size using an Electric field cell counting system. In additi...

Management of chemotherapy-induced adverse effects in the treatment of colorectal cancer

NARCIS (Netherlands)

Jansman, FGA; Sleijfer, DT; de Graaf, JC; Coenen, JLLM; Brouwers, JRBJ

2001-01-01

The anticancer agents fluorouracil, raltitrexed, irinotecan and oxaliplatin show limited efficacy in the treatment of colorectal cancer and may be associated with substantial toxicity. Therefore, the prevention and reduction of chemotherapy-induced adverse effects is of major significance, in

Substantially parallel flux uncluttered rotor machines

Science.gov (United States)

Hsu, John S.

2012-12-11

A permanent magnet-less and brushless synchronous system includes a stator that generates a magnetic rotating field when sourced by polyphase alternating currents. An uncluttered rotor is positioned within the magnetic rotating field and is spaced apart from the stator. An excitation core is spaced apart from the stator and the uncluttered rotor and magnetically couples the uncluttered rotor. The brushless excitation source generates a magnet torque by inducing magnetic poles near an outer peripheral surface of the uncluttered rotor, and the stator currents also generate a reluctance torque by a reaction of the difference between the direct and quadrature magnetic paths of the uncluttered rotor. The system can be used either as a motor or a generator

Neuromuscular and technical abilities related to age in water-polo players.

Science.gov (United States)

De Siati, Fabio; Laffaye, Guillaume; Gatta, Giorgio; Dello Iacono, Antonio; Ardigò, Luca Paolo; Padulo, Johnny

2016-08-01

Testing is one of the important tasks in any multi-step sport programme. In most ball games, coaches assess motor, physical and technical skills on a regular basis in early stages of talent identification in order to further athletes' development. The purpose of the study was to investigate anthropometric variables and vertical jump heights as a free throw effectiveness predictor in water-polo players of different age groups. Two hundred and thirty-six young (10-18 years) male water-polo players partitioned into three age groups underwent anthropometric variables' measures and squat- and countermovement-jump tests, and performed water-polo free throws. Anthropometric variables, vertical jump heights and throw speed - as a proxy for free throw effectiveness - resulted different over age groups. Particularly, throw speed changed from 9.28 to 13.70 m · s(-1) (+48%) from younger to older players. A multiple-regression model indicated that body height, squat-jump height and throw time together explain 52% of variance of throw speed. In conclusion, tall height, high lower limb power and throwing quickness appeared to be relevant determinants for effective free throws. Such indications can help coaches during talent identification and development processes, even by means of novel training strategies. Further research is needed over different maturity statuses.

An absorptive single-pole four-throw switch using multiple-contact MEMS switches and its application to a monolithic millimeter-wave beam-forming network

International Nuclear Information System (INIS)

Lee, Sanghyo; Kim, Jong-Man; Kim, Yong-Kweon; Kwon, Youngwoo

2009-01-01

In this paper, a new absorptive single-pole four-throw (SP4T) switch based on multiple-contact switching is proposed and integrated with a Butler matrix to demonstrate a monolithic beam-forming network at millimeter waves (mm waves). In order to simplify the switching driving circuit and reduce the number of unit switches in an absorptive SP4T switch, the individual switches were replaced with long-span multiple-contact switches using stress-free single-crystalline-silicon MEMS technology. This approach improves the mechanical stability as well as the manufacturing yield, thereby allowing successful integration into a monolithic beam former. The fabricated absorptive SP4T MEMS switch shows insertion loss less than 1.3 dB, return losses better than 11 dB at 30 GHz and wideband isolation performance higher than 39 dB from 20 to 40 GHz. The absorptive SP4T MEMS switch is integrated with a 4 × 4 Butler matrix on a single chip to implement a monolithic beam-forming network, directing beam into four distinct angles. Array factors from the measured data show that the proposed absorptive SPnT MEMS switch can be effectively used for high-performance mm-wave beam-switching systems. This work corresponds to the first demonstration of a monolithic beam-forming network using switched beams

Gaining power and precision by using model-based weights in the analysis of late stage cancer trials with substantial treatment switching.

Science.gov (United States)

Bowden, Jack; Seaman, Shaun; Huang, Xin; White, Ian R

2016-04-30

In randomised controlled trials of treatments for late-stage cancer, it is common for control arm patients to receive the experimental treatment around the point of disease progression. This treatment switching can dilute the estimated treatment effect on overall survival and impact the assessment of a treatment's benefit on health economic evaluations. The rank-preserving structural failure time model of Robins and Tsiatis (Comm. Stat., 20:2609-2631) offers a potential solution to this problem and is typically implemented using the logrank test. However, in the presence of substantial switching, this test can have low power because the hazard ratio is not constant over time. Schoenfeld (Biometrika, 68:316-319) showed that when the hazard ratio is not constant, weighted versions of the logrank test become optimal. We present a weighted logrank test statistic for the late stage cancer trial context given the treatment switching pattern and working assumptions about the underlying hazard function in the population. Simulations suggest that the weighted approach can lead to large efficiency gains in either an intention-to-treat or a causal rank-preserving structural failure time model analysis compared with the unweighted approach. Furthermore, violation of the working assumptions used in the derivation of the weights only affects the efficiency of the estimates and does not induce bias or inflate the type I error rate. The weighted logrank test statistic should therefore be considered for use as part of a careful secondary, exploratory analysis of trial data affected by substantial treatment switching. ©2015 The Authors. Statistics inMedicine Published by John Wiley & Sons Ltd.

Substantiation for Approaches to Treatment of Latent Autoimmune Diabetes in Adults

Directory of Open Access Journals (Sweden)

T.M. Tykhonova

2014-10-01

Conclusions. Analysis of carbohydrate metabolism on the manifestation stage and over time development of latent autoimmune diabetes in adults as well as reduction of β-cells insulin-producing function associated with autoimmune insulitis and progressing while the development of this form of disease, substantiate the rational for insulin administration as this form of diabetes has been diagnosed. If patients with latent autoimmune diabetes in adults have metabolic syndrome clusters it is quite reasonable to add metformin to insulin.

Dark and bright vortex solitons in electromagnetically induced transparent media

International Nuclear Information System (INIS)

Wu Xuan; Xie Xiaotao; Yang Xiaoxue

2006-01-01

We show that dark and bright vortex solitons can exist in three-state electromagnetically induced transparent media under some appropriate conditions. We also analyse the stability of the dark and bright vortex solitons. This work may provide other research opportunities in nonlinear optical experiments and may result in a substantial impact on technology

Renal and endocrine changes in rats with inherited stress-induced arterial hypertension (ISIAH)

DEFF Research Database (Denmark)

Amstislavsky, Sergej; Welker, Pia; Frühauf, Jan-Henning

2006-01-01

Hypertensive inbred rats (ISIAH; inherited stress-induced arterial hypertension) present with baseline hypertension (>170 mmHg in adult rats), but attain substantially higher values upon mild emotional stress. We aimed to characterize key parameters related to hypertension in ISIAH. Kidneys, adre...

Technique of research of severe accidents and substantiation of safety of nuclear systems

International Nuclear Information System (INIS)

Ivanov, E.A.; Tchenov, S.V.

2001-01-01

Work is devoted to development of possible ways of solution of the problems of nuclear safety substantiation. We believe that safety in severe accidents is one of significant factors, which restrict value of nuclear industry in future power production. In connection with it we can conclude followed items: -) Substantiation of safety in severe accidents in nuclear system should be built on a deterministic way of guaranteed exception of heavy consequences; -) It is easy that this aim can be achieved by modeling in functions of common type; -) Main purpose of this work is to show that it is possible to estimate physical allowed state of system in emergency and find of trajectory of heaviest scenarios by optimization procedure; and -) In this work we have developed new method and computer code purposed for study of accident conditions of water cooled un-managed nuclear systems such as cooling ponds of spent fuel, experimental facilities etc. (authors)

Principles of geological substantiation for toxic waste disposal facilities sites selection

International Nuclear Information System (INIS)

Khrushchov, D. P.; Matorin, Eu. M.; Shekhunova, S. B.

2002-01-01

Industrial, domestic and military activities result in accumulation of toxic and hazardous waste. Disposal of these waste comprises two main approaches: technological processing (utilization and destruction) and landfill. According to concepts and programs of advanced countries technological solutions are preferable, but in fact over 70 % of waste are buried in storages, prevailingly of near surface type. The target of this paper is to present principles of geological substantiation of sites selection for toxic and hazardous waste isolation facilities location. (author)

26 CFR 301.6229(c)(2)-1T - Substantial omission of income (temporary).

Science.gov (United States)

2010-04-01

....6229(c)(2)-1T Substantial omission of income (temporary). (a) Partnership return—(1) General rule. (i) If any partnership omits from the gross income stated in its return an amount properly includible... omitted from gross income if information sufficient to apprise the Commissioner of the nature and amount...

On the reliability of retrieval-induced forgetting

Directory of Open Access Journals (Sweden)

Christopher eRowland

2014-11-01

Full Text Available Memory is modified through the act of retrieval. Although retrieving a target piece of information may strengthen the retrieved information itself, it may also serve to weaken retention of related information. This phenomenon, termed retrieval-induced forgetting, has garnered substantial interest for its implications as to why forgetting occurs. The present study attempted to replicate the seminal work by Anderson, Bjork, and Bjork (1994 on retrieval-induced forgetting, given the apparent sensitivity of the effect to certain deviations from the original paradigm developed to study the phenomenon. The study extends the conditions under which retrieval-induced forgetting has been examined by utilizing both a traditional college undergraduate sample (Experiment 1, along with a more diverse internet sample (Experiment 2. In addition, Experiment 3 details a replication attempt of retrieval-induced forgetting using Anderson and Spellman’s (1995 independent cue procedure. Retrieval-induced forgetting was observed when using the traditional retrieval practice paradigm with undergraduate (Experiment 1 and internet (Experiment 2 samples, though the effect was not found when using the independent cue procedure (Experiment 3. Thus, the study can provide an indication as to the robustness of retrieval-induced forgetting to deviations from the traditional college undergraduate samples that have been used in the majority of existing research on the effect.

Tests of the linearity assumption in the dose-effect relationship for radiation-induced cancer

International Nuclear Information System (INIS)

Cohen, A.F.; Cohen, B.L.

1978-01-01

The validity of the BEIR linear extrapolation to low doses of the dose-effect relationship for radiation induced cancer is tested by use of natural radiation making use of selectivity on type of cancer, sex, age group, geographic area, and time period. For lung cancer, a linear interpolation between zero dose-zero effect and the data from radon-induced cancers in miners over-estimates the total number of observed lung cancers in many countries in the early years of this century; the discrepancy is substantially increased if the 30-44 year age range and/or if only females are considered, and by the fact that many other causes of lung cancer are shown to have been important at that time. The degree to which changes of diagnostic efficiency with time can influence the analysis is considered at some length. It is concluded that the linear relationship substantially over-estimates effects of low radiation doses. A similar analysis is applied to leukemia induced by natural radiation, applying selectivity by age, sex, natural background level, and date, and considering other causes. It is concluded that effects substantially larger than those obtained from linear extrapolation are excluded. The use of the selectivities mentioned above is justified by the fact that the incidence of cancer or leukemia is an upper limit on the rate at which it is caused by radiation effects; in determining upper limits it is justifiable to select situations which minimize it. (author)

Linked expression of Ah receptor, ARNT, CYP1A1, and CYP1B1 in rat mammary epithelia, in vitro, is each substantially elevated by specific extracellular matrix interactions that precede branching morphogenesis.

Science.gov (United States)

Larsen, Michele Campaigne; Brake, Paul B; Pollenz, Richard S; Jefcoate, Colin R

2004-11-01

Cytochrome P4501B1 (CYP1B1), the major constitutively expressed CYP in the rat mammary gland, is induced by Ah-receptor (AhR) ligands, while CYP1A1 is predominantly expressed only after induction. These CYPs contribute to carcinogenic activation of polycyclic aromatic hydrocarbons (PAHs). AhR, ARNT, and CYP1B1 were only weakly expressed, even after 2,3,7,8-tetrachlorodibenzo-p-dioxin induction, when rat mammary epithelial cells (RMEC) were cultured on plastic. RMEC cultured on the extracellular matrix (ECM), Matrigel, or on a floating gel of collagen I demonstrated branching morphogenesis and substantially increased basal CYP1B1 and induced CYP1A1 expression, in parallel with large increases in AhR and ARNT expression. Branching was more pronounced in the Wistar Kyoto than in the Wistar Furth rat strain. Although EGF enhanced branching, neither strain nor growth factor treatment substantially impacted CYP expression. Increased AhR and ARNT expression is observed within 24 h of dispersal on Matrigel, substantially prior to branch formation. Culture on thin layers of collagen I, collagen IV, and laminin, respectively, failed to reproduce the branching morphogenesis or increases in AhR, ARNT, or CYP expression. However, adherent, gelled collagen I recapitulated the increased protein expression, without supporting branching. This increased protein expression was closely paralleled by enhanced expression of beta-catenin and E-cadherin, components of cell-cell adhesion complexes. A synthetic peptide that selectively antagonizes integrin-ECM interactions reduced branch formation, without diminishing AhR, ARNT, and CYP expression. These data demonstrate that early ECM surface adhesion interactions mediate AhR and ARNT expression, which enhances CYP expression, independent of branching morphogenesis.

The Impact of Family Engagement and Child Welfare Services on Maltreatment Re-reports and Substantiated Re-reports.

Science.gov (United States)

Fuller, Tamara; Zhang, Saijun

2017-08-01

Despite decades of debate about the most effective ways to intervene with families reported to child protective services (CPS), little evidence exists regarding the types of services or approach that reduce children's risk of additional maltreatment. The current study used data collected during a statewide experimental evaluation of CPS to examine the impact of numerous service variables, family engagement, and family characteristics on the risk of maltreatment re-reports and substantiated re-reports among families initially reported for neglect and risk of harm. The sample included 4,868 families with screened-in reports that were randomly assigned to receive either an investigation or an assessment. The results of the Cox regression analyses found that service duration, intensity, and breadth were unrelated to maltreatment re-report or substantiated re-reports, but caseworker ratings of the service-need match were associated with both. The provision of domestic violence services was related to decreased risk of maltreatment re-reports. Increased levels of family engagement were associated with lowered risk of both maltreatment re-reports and substantiated re-reports. Once the effects of services, engagement, and family characteristics were taken into account, CPS response pathway (investigation or assessment) had no relationship to maltreatment re-reports or substantiated re-reports.

Transfer of motor and perceptual skills from basketball to darts

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Rebecca eRienhoff

2013-09-01

Full Text Available The quiet eye is a perceptual skill associated with expertise and superior performance; however, little is known about the transfer of quiet eye across domains. We attempted to replicate previous skill-based differences in quiet eye and investigated whether transfer of motor and perceptual skills occurs between similar tasks. Throwing accuracy and quiet eye duration for skilled and less-skilled basketball players were examined in basketball free throw shooting and the transfer task of dart throwing. Skilled basketball players showed significantly higher throwing accuracy and longer quiet eye duration in the basketball free throw task compared to their less-skilled counterparts. Further, skilled basketball players showed positive transfer from basketball to dart throwing in accuracy but not in quiet eye duration. Our results raise interesting questions regarding the measurement of transfer between skills.

Information Technology & Applications Corporation v. United States: An Interested Party's "Substantial Chance" at APA Standing

National Research Council Canada - National Science Library

Slicker, Christina

2003-01-01

.... Building on CICA's "interested party" definition with Information Technology's refinement of "substantial chance" rule, the Federal Circuit has effectively translated "APA standing" into the language...

An Anion Conductance, the Essential Component of the Hydroxyl-Radical-Induced Ion Current in Plant Roots

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Igor Pottosin

2018-03-01

Full Text Available Oxidative stress signaling is essential for plant adaptation to hostile environments. Previous studies revealed the essentiality of hydroxyl radicals (HO•-induced activation of massive K+ efflux and a smaller Ca2+ influx as an important component of plant adaptation to a broad range of abiotic stresses. Such activation would modify membrane potential making it more negative. Contrary to these expectations, here, we provide experimental evidence that HO• induces a strong depolarization, from −130 to −70 mV, which could only be explained by a substantial HO•-induced efflux of intracellular anions. Application of Gd3+ and NPPB, non-specific blockers of cation and anion conductance, respectively, reduced HO•-induced ion fluxes instantaneously, implying a direct block of the dual conductance. The selectivity of an early instantaneous HO•-induced whole cell current fluctuated from more anionic to more cationic and vice versa, developing a higher cation selectivity at later times. The parallel electroneutral efflux of K+ and anions should underlie a substantial leak of the cellular electrolyte, which may affect the cell’s turgor and metabolic status. The physiological implications of these findings are discussed in the context of cell fate determination, and ROS and cytosolic K+ signaling.

Substantial nitrogen pollution embedded in international trade

Science.gov (United States)

Oita, Azusa; Malik, Arunima; Kanemoto, Keiichiro; Geschke, Arne; Nishijima, Shota; Lenzen, Manfred

2016-02-01

Anthropogenic emissions of reactive nitrogen to the atmosphere and water bodies can damage human health and ecosystems. As a measure of a nation’s contribution to this potential damage, a country’s nitrogen footprint has been defined as the quantity of reactive nitrogen emitted during the production, consumption and transportation of commodities consumed within that country, whether those commodities are produced domestically or internationally. Here we use global emissions databases, a global nitrogen cycle model, and a global input-output database of domestic and international trade to calculate the nitrogen footprints for 188 countries as the sum of emissions of ammonia, nitrogen oxides and nitrous oxide to the atmosphere, and of nitrogen potentially exportable to water bodies. Per-capita footprints range from under 7 kg N yr-1 in some developing countries to over 100 kg N yr-1 in some wealthy nations. Consumption in China, India, the United States and Brazil is responsible for 46% of global emissions. Roughly a quarter of the global nitrogen footprint is from commodities that were traded across country borders. The main net exporters have significant agricultural, food and textile exports, and are often developing countries, whereas important net importers are almost exclusively developed economies. We conclude that substantial local nitrogen pollution is driven by demand from consumers in other countries.

Main results of substantiation of the ecological safety of the Novovoronezh NPP-2 design

International Nuclear Information System (INIS)

Kopytov, I.I.; Kocher'yan, V.M.; Leonov, S.V.; Chionov, V.G.; Ehrnestova, L.S.

2005-01-01

Paper presents the results of the efforts to determine both the actual (hydrochemical, hydrobiological, geobotanical, soil, radiological) and the predicted parameters of the region ecology derived when substantiating the ecological safety of the Novovoronezh NPP-2 design [ru

Method for the substantial reduction of quenching effects in luminescence spectrometry

Science.gov (United States)

Demas, J.N.; Jones, W.M.; Keller, R.A.

1987-06-26

Method for reducing quenching effects in analytical luminescence measurements. Two embodiments of the present invention are described which relate to a form of time resolution based on the amplitudes and phase shifts of modulated emission signals. In the first embodiment, the measured modulated emission signal is substantially independent of sample quenching at sufficiently high frequencies. In the second embodiment, the modulated amplitude and the phase shift between the emission signal and the excitation source are simultaneously measured. Using either method, the observed modulated amplitude may be reduced to its unquenched value. 3 figs.

Estimating the costs of induced abortion in Uganda: A model-based analysis

Science.gov (United States)

2011-01-01

Background The demand for induced abortions in Uganda is high despite legal and moral proscriptions. Abortion seekers usually go to illegal, hidden clinics where procedures are performed in unhygienic environments by under-trained practitioners. These abortions, which are usually unsafe, lead to a high rate of severe complications and use of substantial, scarce healthcare resources. This study was performed to estimate the costs associated with induced abortions in Uganda. Methods A decision tree was developed to represent the consequences of induced abortion and estimate the costs of an average case. Data were obtained from a primary chart abstraction study, an on-going prospective study, and the published literature. Societal costs, direct medical costs, direct non-medical costs, indirect (productivity) costs, costs to patients, and costs to the government were estimated. Monte Carlo simulation was used to account for uncertainty. Results The average societal cost per induced abortion (95% credibility range) was $177 ($140-$223). This is equivalent to $64 million in annual national costs. Of this, the average direct medical cost was $65 ($49-86) and the average direct non-medical cost was $19 ($16-$23). The average indirect cost was $92 ($57-$139). Patients incurred $62 ($46-$83) on average while government incurred $14 ($10-$20) on average. Conclusion Induced abortions are associated with substantial costs in Uganda and patients incur the bulk of the healthcare costs. This reinforces the case made by other researchers--that efforts by the government to reduce unsafe abortions by increasing contraceptive coverage or providing safe, legal abortions are critical. PMID:22145859

Re-analysis of radiation-induced specific locus mutations in the mouse

International Nuclear Information System (INIS)

Abrahamson, S.; Wolff, S.

1976-01-01

It is stated that a re-analysis of published data on mouse mutation rates induced by x-and gamma rays suggests that the kinetics of induction can be analysed by fitting that data to a parabolic curve. This is interpreted to mean that a substantial proportion of the induced mutations results from gross chromosomal changes such as deletions, some of which are one-track and some of which are two-track. This analysis is based on the assumption that the shape of the dose curve, which in the female is concave upward, reflects the manner in which the mutations are induced rather than representing a one-track (linear) curve whose shape has been modified by differential repair. (author)

Videolaryngoscopes differ substantially in illumination of the oral cavity: A manikin study

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Barbe MA Pieters

2016-01-01

Full Text Available Background and Aims: Insufficient illumination of the oral cavity during endotracheal intubation may result in suboptimal conditions. Consequently, suboptimal illumination and laryngoscopy may lead to potential unwanted trauma to soft tissues of the pharyngeal mucosa. We investigated illumination of the oral cavity by different videolaryngoscopes (VLS in a manikin model. Methods: We measured light intensity from the mouth opening of a Laerdal intubation trainer comparing different direct and indirect VLS at three occasions, resembling optimal to less-than-optimal intubation conditions; at the photographer′s dark room, in an operating theatre and outdoors in bright sunlight. Results: Substantial differences in luminance were detected between VLS. The use of LED light significantly improved light production. All VLS produced substantial higher luminance values in a well-luminated environment compared to the dark photographer′s room. The experiments outside-in bright sunlight-were interfered with by direct sunlight penetration through the synthetic material of the manikin, making correct measurement of luminance in the oropharynx invalid. Conclusion: Illumination of the oral cavity differs widely among direct and indirect VLS. The clinician should be aware of the possibility of suboptimal illumination of the oral cavity and the potential risk this poses for the patient.

A comparison of the technique of the football quarterback pass between high school and university athletes.

Science.gov (United States)

Toffan, Adam; Alexander, Marion J L; Peeler, Jason

2017-07-28

The purpose of the study was to compare the most effective joint movements, segment velocities and body positions to perform the fastest and most accurate pass of high school and university football quarterbacks. Secondary purposes were to develop a quarterback throwing test to assess skill level, to determine which kinematic variables were different between high school and university athletes as well as to determine which variables were significant predictors of quarterback throwing test performance. Ten high school and ten university athletes were filmed for the study, performing nine passes at a target and two passes for maximum distance. Thirty variables were measured using Dartfish Team Pro 4.5.2 video analysis system, and Microsoft Excel was used for statistical analysis. University athletes scored slightly higher than the high school athletes on the throwing test, however this result was not statistically significant. Correlation analysis and forward stepwise multiple regression analysis was performed on both the high school players and the university players in order to determine which variables were significant predictors of throwing test score. Ball velocity was determined to have the strongest predictive effect on throwing test score (r = 0.900) for the high school athletes, however, position of the back foot at release was also determined to be important (r = 0.661) for the university group. Several significant differences in throwing technique between groups were noted during the pass, however, body position at release showed the greatest differences between the two groups. High school players could benefit from more complete weight transfer and decreased throw time to increase throwing test score. University athletes could benefit from increased throw time and greater range of motion in external shoulder rotation and trunk rotation to increase their throwing test score. Coaches and practitioners will be able to use the findings of this research to

Is Induced Abortion Really Declining in Armenia?

Science.gov (United States)

Jilozian, Ann; Agadjanian, Victor

2016-06-01

As in other post-Soviet settings, induced abortion has been widely used in Armenia. However, recent national survey data point to a substantial drop in abortion rates with no commensurate increase in modern contraceptive prevalence and no change in fertility levels. We use data from in-depth interviews with women of reproductive age and health providers in rural Armenia to explore possible underreporting of both contraceptive use and abortion. While we find no evidence that women understate their use of modern contraception, the analysis suggests that induced abortion might indeed be underreported. The potential for underreporting is particularly high for sex-selective abortions, for which there is growing public backlash, and medical abortion, a practice that is typically self-administered outside any professional supervision. Possible underreporting of induced abortion calls for refinement of both abortion registration and relevant survey instruments. Better measurement of abortion dynamics is necessary for successful promotion of effective modern contraceptive methods and reduction of unsafe abortion practices. © 2016 The Population Council, Inc.

Agmatine attenuates methamphetamine-induced hyperlocomotion and stereotyped behavior in mice.

Science.gov (United States)

Kitanaka, Nobue; Kitanaka, Junichi; Hall, F Scott; Uhl, George R; Watabe, Kaname; Kubo, Hitoshi; Takahashi, Hitoshi; Tanaka, Koh-ichi; Nishiyama, Nobuyoshi; Takemura, Motohiko

2014-04-01

We investigated whether pretreatment with the neurotransmitter/neuromodulator agmatine (decarboxylated L-arginine) affected methamphetamine (METH)-induced hyperlocomotion and stereotypy in male ICR mice. Agmatine pretreatment alone had no effects on locomotion or stereotypy, but it produced a dose-dependent attenuation of locomotion and the total incidence of stereotyped behavior induced by a low dose of METH (5 mg/kg). The stereotypy induced by this dose was predominantly characterized by stereotyped sniffing. By contrast, agmatine did not affect the total incidence of stereotypy induced by a higher dose of METH (10 mg/kg). However, the nature of stereotypy induced by this dose of METH was substantially altered; agmatine pretreatment significantly reduced stereotyped biting but significantly increased stereotyped sniffing and persistent locomotion. Agmatine pretreatment therefore appears to produce a rightward shift in the dose-response curve for METH. Pretreatment of mice with piperazine-1-carboxamidine (a putative agmatinase inhibitor) had no effect on locomotion or stereotypy induced by a low dose of METH, suggesting that endogenous agmatine may not regulate the METH action.

78 FR 889 - Finding of Substantial Inadequacy of Implementation Plan; Call for California State...

Science.gov (United States)

2013-01-07

... Resources Defense Council; and Physicians for Social Responsibility--Los Angeles, (``environmental and... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 [EPA-R09-OAR-2012-0721; FRL-9767-3] Finding of Substantial Inadequacy of Implementation Plan; Call for California State Implementation Plan Revision; South...

Rail-induced Traffic in China

Directory of Open Access Journals (Sweden)

Nan He

2017-11-01

Full Text Available The rapid development of China’s railway has exerted an enormous influence on the intercity passenger transport structure in recent years. However, it has not satisfied the passengers’ travel demand due to induced traffic. This paper is committed to solving such issue, with the aim of satisfying the current travel demand, and of anticipating the demand of the predicted traffic growth over the next 20 to 30 years. The paper has considered the increase in rail passenger kilometres caused by the growth of rail kilometres as rail-induced traffic. Based on the concept and former research of induced traffic, the panel data of 26 provinces and 3 municipalities of China between the year 2000 and 2014 were collected, and the elasticity models (including elasticity-based model, distributed lag model, high-speed rail (HSR elasticity model and rail efficiency model have been constructed. The results show the importance of model formation incorporation of rail-induced traffic. It is better to get the correct value in divided zones with different train frequencies or incorporation rail efficiency in cities or provinces. The lag time and rail types also need to be considered. In summary, the results analysis not only confirms the existence of rail-induced traffic, but also provides substantial recommendations to train operation planning.

Central and Peripheral Mechanisms of Antipsychotic Medication Induced Metabolic Dysregulation

Science.gov (United States)

2016-10-01

effects characterized by substantial weight gain, glucose intolerance, insulin resistance , hypertension and dyslipidemia as well as increased risks for...sufficiently powered to resolve potential effects of D2R absence on APDs’ effects on glucose tolerance, insulin resistance , glucose stimulated insulin ...Zachary Freyberg, to optimize the dietary conditions responsible for inducing the development of insulin resistance . Initial studies with standard 60

Measuring technique of super high temperature thermal properties of reactor core materials

International Nuclear Information System (INIS)

Ono, Akira; Baba, Tetsuya; Watanabe, Hideo; Matsumoto, Tsuyoshi

1998-01-01

In this study, thermal properties of reactor core materials used for water cooled reactors and FBR were tried to develop a technique to measure their melt states at less than 3,000degC in order to contribute more correct evaluation of the reactor core behavior at severe accident. Then, a thermal property measuring method of high temperature melt by using floating method was investigated and its fundamental design was begun to investigate under a base of optimum judgement on the air flow floating throw-down method. And, in order to measure emissivity of melt specimen surface essential for correct temperature measurement using the throw down method, a spectroscopic emissivity measuring unit using an ellipsometer was prepared and induced. On the thermal properties measurement using the holding method, a specimen container to measure thermal diffusiveness of the high temperature melts by using laser flashing method was tried to prepare. (G.K.)

Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems.

Science.gov (United States)

Luger, Anna-Luisa; Sauer, Benedikt; Lorenz, Nadja I; Engel, Anna L; Braun, Yannick; Voss, Martin; Harter, Patrick N; Steinbach, Joachim P; Ronellenfitsch, Michael W

2018-05-17

Inducible gene expression is an important tool in molecular biology research to study protein function. Most frequently, the antibiotic doxycycline is used for regulation of so-called tetracycline (Tet)-inducible systems. In contrast to stable gene overexpression, these systems allow investigation of acute and reversible effects of cellular protein induction. Recent reports have already called for caution when using Tet-inducible systems as the employed antibiotics can disturb mitochondrial function and alter cellular metabolism by interfering with mitochondrial translation. Reprogramming of energy metabolism has lately been recognized as an important emerging hallmark of cancer and is a central focus of cancer research. Therefore, the scope of this study was to systematically analyze dose-dependent metabolic effects of doxycycline on a panel of glioma cell lines with concomitant monitoring of gene expression from Tet-inducible systems. We report that doxycycline doses commonly used with inducible expression systems (0.01⁻1 µg/mL) substantially alter cellular metabolism: Mitochondrial protein synthesis was inhibited accompanied by reduced oxygen and increased glucose consumption. Furthermore, doxycycline protected human glioma cells from hypoxia-induced cell death. An impairment of cell growth was only detectable with higher doxycycline doses (10 µg/mL). Our findings describe settings where doxycycline exerts effects on eukaryotic cellular metabolism, limiting the employment of Tet-inducible systems.

Confidence Intervals: From tests of statistical significance to confidence intervals, range hypotheses and substantial effects

Directory of Open Access Journals (Sweden)

Dominic Beaulieu-Prévost

2006-03-01

Full Text Available For the last 50 years of research in quantitative social sciences, the empirical evaluation of scientific hypotheses has been based on the rejection or not of the null hypothesis. However, more than 300 articles demonstrated that this method was problematic. In summary, null hypothesis testing (NHT is unfalsifiable, its results depend directly on sample size and the null hypothesis is both improbable and not plausible. Consequently, alternatives to NHT such as confidence intervals (CI and measures of effect size are starting to be used in scientific publications. The purpose of this article is, first, to provide the conceptual tools necessary to implement an approach based on confidence intervals, and second, to briefly demonstrate why such an approach is an interesting alternative to an approach based on NHT. As demonstrated in the article, the proposed CI approach avoids most problems related to a NHT approach and can often improve the scientific and contextual relevance of the statistical interpretations by testing range hypotheses instead of a point hypothesis and by defining the minimal value of a substantial effect. The main advantage of such a CI approach is that it replaces the notion of statistical power by an easily interpretable three-value logic (probable presence of a substantial effect, probable absence of a substantial effect and probabilistic undetermination. The demonstration includes a complete example.

Substantial population structure of Plasmodium vivax in Thailand facilitates identification of the sources of residual transmission.

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Veerayuth Kittichai

2017-10-01

Full Text Available Plasmodium vivax transmission in Thailand has been substantially reduced over the past 10 years, yet it remains highly endemic along international borders. Understanding the genetic relationship of residual parasite populations can help track the origins of the parasites that are reintroduced into malaria-free regions within the country.A total of 127 P. vivax isolates were genotyped from two western provinces (Tak and Kanchanaburi and one eastern province (Ubon Ratchathani of Thailand using 10 microsatellite markers. Genetic diversity was high, but recent clonal expansion was detected in all three provinces. Substantial population structure and genetic differentiation of parasites among provinces suggest limited gene flow among these sites. There was no haplotype sharing among the three sites, and a reduced panel of four microsatellite markers was sufficient to assign the parasites to their provincial origins.Significant parasite genetic differentiation between provinces shows successful interruption of parasite spread within Thailand, but high diversity along international borders implies a substantial parasite population size in these regions. The provincial origin of P. vivax cases can be reliably determined by genotyping four microsatellite markers, which should be useful for monitoring parasite reintroduction after malaria elimination.

Substantial population structure of Plasmodium vivax in Thailand facilitates identification of the sources of residual transmission.

Science.gov (United States)

Kittichai, Veerayuth; Koepfli, Cristian; Nguitragool, Wang; Sattabongkot, Jetsumon; Cui, Liwang

2017-10-01

Plasmodium vivax transmission in Thailand has been substantially reduced over the past 10 years, yet it remains highly endemic along international borders. Understanding the genetic relationship of residual parasite populations can help track the origins of the parasites that are reintroduced into malaria-free regions within the country. A total of 127 P. vivax isolates were genotyped from two western provinces (Tak and Kanchanaburi) and one eastern province (Ubon Ratchathani) of Thailand using 10 microsatellite markers. Genetic diversity was high, but recent clonal expansion was detected in all three provinces. Substantial population structure and genetic differentiation of parasites among provinces suggest limited gene flow among these sites. There was no haplotype sharing among the three sites, and a reduced panel of four microsatellite markers was sufficient to assign the parasites to their provincial origins. Significant parasite genetic differentiation between provinces shows successful interruption of parasite spread within Thailand, but high diversity along international borders implies a substantial parasite population size in these regions. The provincial origin of P. vivax cases can be reliably determined by genotyping four microsatellite markers, which should be useful for monitoring parasite reintroduction after malaria elimination.

26 CFR 1.162-17 - Reporting and substantiation of certain business expenses of employees.

Science.gov (United States)

2010-04-01

... Individuals and Corporations § 1.162-17 Reporting and substantiation of certain business expenses of employees.... The term “ordinary and necessary business expenses” means only those expenses which are ordinary and..., reimbursements, or otherwise, exceeds the ordinary and necessary business expenses paid or incurred by the...

Collision-induced spectroscopy with long-range intermolecular interactions: A diagrammatic representation and the invariant form of the induced properties

International Nuclear Information System (INIS)

Kouzov, A. P.; Chrysos, M.; Rachet, F.; Egorova, N. I.

2006-01-01

Collision-induced properties of two interacting molecules a and b are derived by means of a general diagrammatic method involving M molecule-molecule and N photon-molecule couplings. The method is an extension of previous graphical treatments of nonlinear optics because it exhaustively determines interaction-induced polarization mechanisms in a trustworthy and handy fashion. Here we focus on long-range intermolecular interactions. Retardation effects are neglected. A fully quantum-mechanical treatment of the molecules is made whereas second quantization for the electromagnetic field, in the nonrelativistic approximation, is implicitly applied. The collision-induced absorption, Raman, and hyper-Raman processes are viewed and studied, through guiding examples, as specific cases N=1, 2, and 3, respectively. In Raman (N=2), the standard first-order (M=1) dipole-induced dipole term of the incremental polarizability, Δα, is the result of a coupling of the two photons with distinct molecules, a and b, which perturb each other via a dipole-dipole mechanism. Rather, when the two photons interact with the same molecule, a or b, the (N=2, M=1) graphs predict the occurrence of a nonlinear polarization mechanism. The latter is expected to contribute substantially to the collision-induced Raman bands by certain molecular gases

Extremely short duration high intensity interval training substantially improves insulin action in young healthy males

DEFF Research Database (Denmark)

Babraj, John A; Vollaard, Niels B J; Keast, Cameron

2009-01-01

BACKGROUND: Traditional high volume aerobic exercise training reduces cardiovascular and metabolic disease risk but involves a substantial time commitment. Extremely low volume high-intensity interval training (HIT) has recently been demonstrated to produce improvements to aerobic function...... cycle sprints per session). Aerobic performance (250-kJ self-paced cycling time trial), and glucose, insulin and NEFA responses to a 75-g oral glucose load (oral glucose tolerance test; OGTT) were determined before and after training. RESULTS: Following 2 weeks of HIT, the area under the plasma glucose......, to substantially improve insulin action in young sedentary subjects is remarkable. This novel time-efficient training paradigm can be used as a strategy to reduce metabolic risk factors in young and middle aged sedentary populations who otherwise would not adhere to time consuming traditional aerobic exercise...

Glucagon-like peptide-1 analogs against antipsychotic-induced weight gain

DEFF Research Database (Denmark)

Ebdrup, Bjørn H; Knop, Filip K; Ishøy, Pelle L

2012-01-01

between schizophrenia and overweight patients. DISCUSSION: Current interventions against antipsychotic-induced weight gain do not facilitate a substantial and lasting weight loss. GLP-1 analogues used in the treatment of type 2 diabetes are associated with significant and sustained weight loss...... are already compromised in normal weight patients with schizophrenia. Here we outline the current strategies against antipsychotic-induced weight gain, and we describe peripheral and cerebral effects of the gut hormone glucagon-like peptide-1 (GLP-1). Moreover, we account for similarities in brain changes...... in overweight patients. Potential effects of treating schizophrenia patients with antipsychotic-induced weight gain with GLP-1 analogues are discussed. CONCLUSIONS: We propose that adjunctive treatment with GLP-1 analogues may constitute a new avenue to treat and prevent metabolic and cerebral deficiencies...

Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice.

Science.gov (United States)

Nair, S S; Manalil, J J; Ramavarma, S K; Suseela, I M; Thekkepatt, A; Raghavamenon, A C

2016-02-01

Virgin coconut oil (VCO) is an unrefined kernal oil, prepared from Cocos nucifera L., having substantial nutritional and medicinal value. Experimental studies have suggested its antioxidant, anti-inflammatory, immunostimulatory and hypolipidemic effects. The present study assesses its effect on formalin-induced chronic inflammation and cyclophosphamide (CTX)-induced systemic toxicity in murine models. Oral administration of VCO effectively reduced formalin-induced paw oedema in mice with more or less similar efficacy as that of diclofenac. The CTX-induced hike in blood urea, creatinine, thiobarbituric acid reactive substances (TBARS) and liver marker enzymes in mice was marginally decreased by VCO (8 g/kg body weight) ingestion orally. The liver and kidney catalase, superoxide dismutase and glutathione peroxidase activities, together with cellular glutathione and TBARS levels, were found to be improved in these animals. Overall the study reveals the protective efficacy of VCO against secondary toxicity induced by CTX possibly through its antioxidant and anti-inflammatory properties. © The Author(s) 2015.

People attending pulmonary rehabilitation demonstrate a substantial engagement with technology and willingness to use telerehabilitation: a survey

Directory of Open Access Journals (Sweden)

Zachariah Seidman

2017-07-01

Conclusion: People attending metropolitan pulmonary rehabilitation, maintenance exercise classes and support groups had substantial technology engagement, with high device access and use, and good self-rated technology competence. The majority of participants were willing to use telerehabilitation, especially if they were regular users of technology devices. [Seidman Z, McNamara R, Wootton S, Leung R, Spencer L, Dale M, Dennis S, McKeough Z (2017 People attending pulmonary rehabilitation demonstrate a substantial engagement with technology and willingness to use telerehabilitation: a survey. Journal of Physiotherapy 63: 175–181

Long-Lasting Cortical Reorganization as the Result of Motor Imagery of Throwing a Ball in a Virtual Tennis Court

Science.gov (United States)

Cebolla, Ana M.; Petieau, Mathieu; Cevallos, Carlos; Leroy, Axelle; Dan, Bernard; Cheron, Guy

2015-01-01

In order to characterize the neural signature of a motor imagery (MI) task, the present study investigates for the first time the oscillation characteristics including both of the time-frequency measurements, event related spectral perturbation and intertrial coherence (ITC) underlying the variations in the temporal measurements (event related potentials, ERP) directly related to a MI task. We hypothesize that significant variations in both of the time-frequency measurements underlie the specific changes in the ERP directly related to MI. For the MI task, we chose a simple everyday task (throwing a tennis ball), that does not require any particular motor expertise, set within the controlled virtual reality scenario of a tennis court. When compared to the rest condition a consistent, long-lasting negative fronto-central ERP wave was accompanied by significant changes in both time frequency measurements suggesting long-lasting cortical activity reorganization. The ERP wave was characterized by two peaks at about 300 ms (N300) and 1000 ms (N1000). The N300 component was centrally localized on the scalp and was accompanied by significant phase consistency in the delta brain rhythms in the contralateral central scalp areas. The N1000 component spread wider centrally and was accompanied by a significant power decrease (or event related desynchronization) in low beta brain rhythms localized in fronto-precentral and parieto-occipital scalp areas and also by a significant power increase (or event related synchronization) in theta brain rhythms spreading fronto-centrally. During the transition from N300 to N1000, a contralateral alpha (mu) as well as post-central and parieto-theta rhythms occurred. The visual representation of movement formed in the minds of participants might underlie a top-down process from the fronto-central areas which is reflected by the amplitude changes observed in the fronto-central ERPs and by the significant phase synchrony in contralateral fronto

Substantial equivalence--an appropriate paradigm for the safety assessment of genetically modified foods?

International Nuclear Information System (INIS)

Kuiper, Harry A.; Kleter, Gijs A.; Noteborn, Hub P.J.M.; Kok, Esther J.

2002-01-01

Safety assessment of genetically modified food crops is based on the concept of substantial equivalence, developed by OECD and further elaborated by FAO/WHO. The concept embraces a comparative approach to identify possible differences between the genetically modified food and its traditional comparator, which is considered to be safe. The concept is not a safety assessment in itself, it identifies hazards but does not assess them. The outcome of the comparative exercise will further guide the safety assessment, which may include (immuno)toxicological and biochemical testing. Application of the concept of substantial equivalence may encounter practical difficulties: (i) the availability of near-isogenic parental lines to compare the genetically modified food with; (ii) limited availability of methods for the detection of (un)intended effects resulting from the genetic modification; and (iii) limited information on natural variations in levels of relevant crop constituents. In order to further improve the methodology for identification of unintended effects, new 'profiling' methods are recommended. Such methods will allow for the screening of potential changes in the modified host organism at different integration levels, i.e. at the genome level, during gene expression and protein translation, and at the level of cellular metabolism

Theoretical-and-Methodological Substantiation of Multilingual Model Activity in Kazakhstan Higher School Education System

Science.gov (United States)

Ospanova, Bikesh Revovna; Azimbayeva, Zhanat Amantayevna; Timokhina, Tatyana Vladimirovna; Seydakhmetova, Zergul Koblandiyevna

2016-01-01

The need of implementing the model of professional development in training an expert in the conditions of multilingualism is considered. The possibility of using the multilingual approach in the context of present day education with the use of innovative technologies of training is substantiated, the definition of "multilingual…

Substantiated childhood maltreatment and young adulthood cannabis use disorders: A pre-birth cohort study.

Science.gov (United States)

Abajobir, Amanuel Alemu; Najman, Jake Moses; Williams, Gail; Strathearn, Lane; Clavarino, Alexandra; Kisely, Steve

2017-10-01

This study investigates the association between exposure to prospectively-substantiated childhood maltreatment between 0 and 14 years of age and lifetime cannabis use, abuse and dependence reported at 21 years. Data were taken from 2526 (51.6% female) participants in the Mater Hospital-University of Queensland Study of Pregnancy, a pre-birth, prospective, cohort study. Prospectively-substantiated cases of childhood maltreatment, reported to the government child protection agencies between 0 and 14 years of age, were linked to CIDI DSM-IV self-report data from the 21-year follow-up. Exposure to any childhood maltreatment, and childhood neglect in particular, predicted subsequent cannabis abuse with adjusted odds ratios (AORs) of 1.79 and 2.62, respectively. Any childhood maltreatment, physical abuse, emotional abuse and neglect predicted cannabis dependence with AORs of 2.47, 2.81, 2.44 and 2.68, respectively. The associations for an early age of onset of cannabis abuse and dependence were significant and consistent for maltreated children. In addition, frequency of maltreatment substantiations predicted cannabis abuse, dependence and an early age of onset of these disorders. The AORs for cannabis ever use without any DSM-IV cannabis disorder were 1.78 for any maltreatment and 2.15 for emotional abuse. Any childhood maltreatment and neglect predicted lifetime ever cannabis use, as well as cannabis use disorder. There was little evidence for any interaction between gender and different forms of childhood maltreatment and its association with cannabis use disorders. Physical abuse, emotional abuse and neglect, as well as multiple episodes of maltreatment independently predicted cannabis use disorders. Copyright © 2017 Elsevier B.V. All rights reserved.

Specific macrophage subtypes influence the progression of rhabdomyolysis-induced kidney injury.

Science.gov (United States)

Belliere, Julie; Casemayou, Audrey; Ducasse, Laure; Zakaroff-Girard, Alexia; Martins, Frédéric; Iacovoni, Jason S; Guilbeau-Frugier, Céline; Buffin-Meyer, Bénédicte; Pipy, Bernard; Chauveau, Dominique; Schanstra, Joost P; Bascands, Jean-Loup

2015-06-01

Rhabdomyolysis can be life threatening if complicated by AKI. Macrophage infiltration has been observed in rat kidneys after glycerol-induced rhabdomyolysis, but the role of macrophages in rhabdomyolysis-induced AKI remains unknown. Here, in a patient diagnosed with rhabdomyolysis, we detected substantial macrophage infiltration in the kidney. In a mouse model of rhabdomyolysis-induced AKI, diverse renal macrophage phenotypes were observed depending on the stage of the disease. Two days after rhabdomyolysis, F4/80(low)CD11b(high)Ly6b(high)CD206(low) kidney macrophages were dominant, whereas by day 8, F4/80(high)CD11b(+)Ly6b(low)CD206(high) cells became the most abundant. Single-cell gene expression analyses of FACS-sorted macrophages revealed that these subpopulations were heterogeneous and that individual cells simultaneously expressed both M1 and M2 markers. Liposomal clodronate-mediated macrophage depletion significantly reduced the early infiltration of F4/80(low)CD11b(high)Ly6b(high)CD206(low) macrophages. Furthermore, transcriptionally regulated targets potentially involved in disease progression, including fibronectin, collagen III, and chemoattractants that were identified via single-cell analysis, were verified as macrophage-dependent in situ. In vitro, myoglobin treatment induced proximal tubular cells to secrete chemoattractants and macrophages to express proinflammatory markers. At day 30, liposomal clodronate-mediated macrophage depletion reduced fibrosis and improved both kidney repair and mouse survival. Seven months after rhabdomyolysis, histologic lesions were still present but were substantially reduced with prior depletion of macrophages. These results suggest an important role for macrophages in rhabdomyolysis-induced AKI progression and advocate the utility of long-term follow-up for patients with this disease. Copyright © 2015 by the American Society of Nephrology.

Eliminating the extinction-induced reflection enlargement in the XRD characterisations of textured films

International Nuclear Information System (INIS)

Tomov, I.

2003-01-01

This investigation throws additional light on the nature of secondary extinction (SE). A method is described for computing the correct integral breadth using the observed one, which is affected by SE. The method is applied for more precise measuring the integral breadths of reflections corresponding to the ideal directions of main texture components of electrodeposited silver films. Further, the effect of SE on the systematic error in integral breadth measurements is investigated in dependence on the reflectivity and pole density. (Abstract Copyright [2003], Wiley Periodicals, Inc.) [de

Eliminating the extinction-induced reflection enlargement in the XRD characterisations of textured films

CERN Document Server

Tomov, I

2003-01-01

This investigation throws additional light on the nature of secondary extinction (SE). A method is described for computing the correct integral breadth using the observed one, which is affected by SE. The method is applied for more precise measuring the integral breadths of reflections corresponding to the ideal directions of main texture components of electrodeposited silver films. Further, the effect of SE on the systematic error in integral breadth measurements is investigated in dependence on the reflectivity and pole density. (Abstract Copyright [2003], Wiley Periodicals, Inc.)

Involvement of activation-induced cytidine deaminase in skin cancer development.

Science.gov (United States)

Nonaka, Taichiro; Toda, Yoshinobu; Hiai, Hiroshi; Uemura, Munehiro; Nakamura, Motonobu; Yamamoto, Norio; Asato, Ryo; Hattori, Yukari; Bessho, Kazuhisa; Minato, Nagahiro; Kinoshita, Kazuo

2016-04-01

Most skin cancers develop as the result of UV light-induced DNA damage; however, a substantial number of cases appear to occur independently of UV damage. A causal link between UV-independent skin cancers and chronic inflammation has been suspected, although the precise mechanism underlying this association is unclear. Here, we have proposed that activation-induced cytidine deaminase (AID, encoded by AICDA) links chronic inflammation and skin cancer. We demonstrated that Tg mice expressing AID in the skin spontaneously developed skin squamous cell carcinoma with Hras and Trp53 mutations. Furthermore, genetic deletion of Aicda reduced tumor incidence in a murine model of chemical-induced skin carcinogenesis. AID was expressed in human primary keratinocytes in an inflammatory stimulus-dependent manner and was detectable in human skin cancers. Together, the results of this study indicate that inflammation-induced AID expression promotes skin cancer development independently of UV damage and suggest AID as a potential target for skin cancer therapeutics.

Substantially Evolutionary Theorizing in Designing Software-Intensive Systems

Directory of Open Access Journals (Sweden)

Petr Sosnin

2018-04-01

Full Text Available Useful inheritances from scientific experience open perspective ways for increasing the degree of success in designing of systems with software. One such way is a search and build applied theory that takes into account the nature of design and the specificity of software engineering. This paper presents a substantially evolutionary approach to creating the project theories, the application of which leads to positive effects that are traditionally expected from theorizing. Any implementation of the approach is based on a reflection by designers of an operational space of designing onto a semantic memory of a question-answer type. One of the results of such reflection is a system of question-answer nets, the nodes of which register facts of interactions of designers with accessible experience. A set of such facts is used by designers for creating and using the theory that belongs to the new subclass of Grounded Theories. This sub-class is oriented on organizationally behavioral features of a project’s work based on design thinking, automated mental imagination, and thought experimenting that facilitate increasing the degree of controlled intellectualization in the design process and, correspondingly, increasing the degree of success in the development of software-intensive systems.

Preventing overuse shoulder injuries among throwing athletes: a cluster-randomised controlled trial in 660 elite handball players.

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Andersson, Stig Haugsboe; Bahr, Roald; Clarsen, Benjamin; Myklebust, Grethe

2017-07-01

Shoulder problems are highly prevalent among elite handball players. Reduced glenohumeral rotation, external rotation weakness and scapula dyskinesis have been identified as risk factors. Evaluate the effect of an exercise programme designed to reduce the prevalence of shoulder problems in elite handball. 45 elite handball teams (22 female teams, 23 male teams, 660 players) were cluster randomised (22 teams, 331 players in the intervention group, 23 teams, 329 players in the control group) and followed for 1 competitive season (7 months). The Oslo Sports Trauma Research Center (OSTRC) Shoulder Injury Prevention Programme, an exercise programme to increase glenohumeral internal rotation, external rotation strength and scapular muscle strength, as well as improve kinetic chain and thoracic mobility, was delivered by coaches and captains 3 times per week as a part of the handball warm-up. The main outcome measures, prevalence of shoulder problems and substantial shoulder problems, were measured monthly. The average prevalence of shoulder problems during the season was 17% (95% CI 16% to 19%) in the intervention group and 23% (95% CI 21% to 26%) in the control group (mean difference 6%). The average prevalence of substantial shoulder problems was 5% (95% CI 4% to 6%) in the intervention group and 8% (95% CI 7% to 9%) in the control group (mean difference 3%). Using generalised estimating equation models, a 28% lower risk of shoulder problems (OR 0.72, 95% CI 0.52 to 0.98, p=0.038) and 22% lower risk of substantial shoulder problems (OR 0.78, 95% CI 0.53 to 1.16, p=0.23) were observed in the intervention group compared with the control group. The OSTRC Shoulder Injury Prevention Programme reduced the prevalence of shoulder problems in elite handball and should be included as a part of the warm-up. ISRCTN96217107. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Validity and Reliability of a Medicine Ball Explosive Power Test.

Science.gov (United States)

Stockbrugger, Barry A.; Haennel, Robert G.

2001-01-01

Evaluated the validity and reliability of a medicine ball throw test to evaluate explosive power. Data on competitive sand volleyball players who performed a medicine ball throw and a standard countermovement jump indicated that the medicine ball throw test was a valid and reliable way to assess explosive power for an analogous total-body movement…

A wireless sensor system for a biofeedback training of hammer throwers.

Science.gov (United States)

Wang, Ye; Wan, Bingjun; Li, Hua; Shan, Gongbing

2016-01-01

Hammer-throw has a long-standing history in track and field, but unlike some other sports events, men's hammer throw has not seen a new world record since 1986. One of the possible reasons for this stagnation could be the lack of real-time biomechanical feedback training. In this study, we proposed to establish scientifically described training targets and routes, which in turn required tools that could measure and quantify characteristics of an effective hammer-throw. Towards this goal, we have developed a real-time biomechanical feedback device-a wireless sensor system-to help the training of hammer-throw. The system includes two sensors-an infrared proximity sensor for tracing the hip vertical movement and a load cell for recording the wire tension during a hammer-throw. The system uses XBees for data transmission and an Arduino processor for data processing and system control. The results revealed that the wire tension measurement could supply sufficient key features for coaches to analyze hammer-throw and give real-time feedback for improving training efficiency.

Reduction of errors during practice facilitates fundamental movement skill learning in children with intellectual disabilities.

Science.gov (United States)

Capio, C M; Poolton, J M; Sit, C H P; Eguia, K F; Masters, R S W

2013-04-01

Children with intellectual disabilities (ID) have been found to have inferior motor proficiencies in fundamental movement skills (FMS). This study examined the effects of training the FMS of overhand throwing by manipulating the amount of practice errors. Participants included 39 children with ID aged 4-11 years who were allocated into either an error-reduced (ER) training programme or a more typical programme in which errors were frequent (error-strewn, ES). Throwing movement form, throwing accuracy, and throwing frequency during free play were evaluated. The ER programme improved movement form, and increased throwing activity during free play to a greater extent than the ES programme. Furthermore, ER learners were found to be capable of engaging in a secondary cognitive task while manifesting robust throwing accuracy performance. The findings support the use of movement skills training programmes that constrain practice errors in children with ID, suggesting that such approach results in improved performance and heightened movement engagement in free play. © 2012 The Authors. Journal of Intellectual Disability Research © 2012 Blackwell Publishing Ltd.

Pharmaceutical manufacturing facility discharges can substantially increase the pharmaceutical load to U.S. wastewaters

Science.gov (United States)

Scott, Tia-Marie; Phillips, Patrick J.; Kolpin, Dana W.; Colella, Kaitlyn M.; Furlong, Edward T.; Foreman, William T.; Gray, James L.

2018-01-01

Discharges from pharmaceutical manufacturing facilities (PMFs) previously have been identified as important sources of pharmaceuticals to the environment. Yet few studies are available to establish the influence of PMFs on the pharmaceutical source contribution to wastewater treatment plants (WWTPs) and waterways at the national scale. Consequently, a national network of 13 WWTPs receiving PMF discharges, six WWTPs with no PMF input, and one WWTP that transitioned through a PMF closure were selected from across the United States to assess the influence of PMF inputs on pharmaceutical loading to WWTPs. Effluent samples were analyzed for 120 pharmaceuticals and pharmaceutical degradates. Of these, 33 pharmaceuticals had concentrations substantially higher in PMF-influenced effluent (maximum 555,000 ng/L) compared to effluent from control sites (maximum 175 ng/L). Concentrations in WWTP receiving PMF input are variable, as discharges from PMFs are episodic, indicating that production activities can vary substantially over relatively short (several months) periods and have the potential to rapidly transition to other pharmaceutical products. Results show that PMFs are an important, national-scale source of pharmaceuticals to the environment.

PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE SNOWBALL THROWING TERHADAP HASIL BELAJAR SISWA PADA KONSEP SALING KETERGANTUNGAN DALAM EKOSISTEM DI KELAS VII SMP NEGERI 18 PEKANBARU TAHUN AJARAN 2014 / 2015

Directory of Open Access Journals (Sweden)

Jumiati Jumiati

2017-07-01

Full Text Available The aim of this research was to find out the effect of cooperative learning type snowballthrowing to improve student learning achievement on the reliance mutualin in theecosystem concept. The research was conducted at SMP Negeri 18 Pekanbaru at firstsemester in academic years 2014 / 2015. Design of the research was quasi-experimental,The Matching Only Pretest – Posttest Control Group Design. Sample of the research wastaken two classes with the number of students in each 40 people who were taken by usingsimple random sampling technique. The data were collected by using pretest, posttest andteacher’s and students’ activities observation sheets. The data analysis technique used inthis research was 2 sample independent t test, if the data were normal and homogen. Themean N-gain experimental class was 0.72 high category and the control class was 0.44medium category. Based on the result of statistical test that there were significantdifferences between the mean N-Gain experimental class and control class. Thereby canbe conluded that there were significant application of cooperative learning type snowballthrowing to improve student learning achievement on the reliance mutualin in theecosystem concept class VII SMPN 18 pekanbaru academic year 2014 / 2015.Key words : snowball throwing, learning achievement, ecosystem.

News Teaching Support: New schools network launched Competition: Observatory throws open doors to a select few Festival: Granada to host 10th Ciencia en Acción Centenary: Science Museum celebrates 100 years Award: Queen's birthday honour for science communicator Teacher Training: Training goes where it's needed Conference: Physics gets creative in Christchurch Conference: Conference is packed with ideas Poster Campaign: Bus passengers learn about universe Forthcoming events

Science.gov (United States)

2009-09-01

Teaching Support: New schools network launched Competition: Observatory throws open doors to a select few Festival: Granada to host 10th Ciencia en Acción Centenary: Science Museum celebrates 100 years Award: Queen's birthday honour for science communicator Teacher Training: Training goes where it's needed Conference: Physics gets creative in Christchurch Conference: Conference is packed with ideas Poster Campaign: Bus passengers learn about universe Forthcoming events

Further substantial improvement of interventional diagnosis and treatment via portal vein system

International Nuclear Information System (INIS)

Yang Weizhu; Chen Yongde

2006-01-01

Along with the development of interventional appliances and proficiency of operational skills, the interventional diagnosis and treatment via hepatic portal vein system have achieved great progress and improvement. However, in order to further exploit the advantages of interventional diagnosis and treatment, the review of the anatomical structures, normal aberrance of portal venous system were needed. Getting familiar with pathologic condition to discover the new interventional appliances and embolic agents, and then in term of conduct the research on a very tough substantial base in a down-to-earth manner were important. (authors)

77 FR 65169 - Extension of Certain Timber Sale Contracts; Finding of Substantial Overriding Public Interest

Science.gov (United States)

2012-10-25

... that are in breach, or (6) contracts when the purchaser's processing facility has not operated during... DEPARTMENT OF AGRICULTURE Forest Service Extension of Certain Timber Sale Contracts; Finding of Substantial Overriding Public Interest AGENCY: Forest Service, USDA. ACTION: Notice of contract extensions...

Lack of Substantial Post-Cessation Weight Increase in Electronic Cigarettes Users

Directory of Open Access Journals (Sweden)

Cristina Russo

2018-03-01

Full Text Available Minimization of post-cessation weight gain in quitters is important, but existing approaches (e.g., antismoking medications shows only limited success. We investigated changes in body weight in smokers who quit or reduced substantially their cigarette consumption by switching to electronic cigarettes (ECs use. Body weight and smoking/vaping history were extracted from medical records of smokers and ex-smokers to match three study groups: (1 regular EC users on at least two consecutive follow-up visits; (2 regular smokers (and not using ECs; (3 subjects who reported sustained smoking abstinence after completing a cessation program. Review of their medical records was conducted at two follow-up visits at 6- (F/U 6m and 12-months (F/U 12m. A total of 86 EC users, 93 regular smokers, and 44 quitters were studied. In the EC users study group, cigarettes/day use decreased from 21.1 at baseline to 1.8 at F/U 12m (p < 0.0001. Dual usage was reported by approximately 50% of EC users. Both within factor (time, p < 0.0001 and between factor (study groups, p < 0.0001 produced significant effect on weight (% change from baseline, with a significant 4.8% weight gain from baseline in the quitters study group at F/U 12m. For the EC users, weight gain at F/U 12m was only 1.5% of baseline. There was no evidence of post-cessation weight increase in those who reduced substantially cigarette consumption by switching to ECs (i.e., dual users and only modest post-cessation weight increase was reported in exclusive EC users at F/U 12m. By reducing weight gain and tobacco consumption, EC-based interventions may promote an overall improvement in quality of life.

Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting

NARCIS (Netherlands)

Slof-Op 't Landt, M. C. T.; Meulenbelt, I.; Bartels, M.; Suchiman, E.; Middeldorp, C. M.; Houwing-Duistermaat, J. J.; van Trier, J.; Onkenhout, E. J.; Vink, J. M.; van Beijsterveldt, C. E. M.; Brandys, M. K.; Sanders, N.; Zipfel, S.; Herzog, W.; Herpertz-Dahlmann, B.; Klampfl, K.; Fleischhaker, C.; Zeeck, A.; de Zwaan, M.; Herpertz, S.; Ehrlich, S.; van Elburg, A. A.; Adan, R. A. H.; Scherag, S.; Hinney, A.; Hebebrand, J.; Boomsma, D. I.; van Furth, E. F.; Slagboom, P. E.

2011-01-01

Twin studies suggest that genetic factors play a substantial role in anorexia nervosa (AN) and self-induced vomiting (SV), a key symptom that is shared among different types of eating disorders (EDs). We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of

Association study in eating disorders: TPH2 associates with anorexia nervosa and self induced vomiting

NARCIS (Netherlands)

Slof-Op 't Landt, M.C.T.; Meulenbelt, I.; Bartels, M.; Suchiman, E.; Middeldorp, C.M.; Houwing-Duistermaat, J.J.; van Trier, J.; Onkenhout, E.J.; Vink, J.M.; van Beijsterveldt, C.E.M.; Brandys, M.K.; Sanders, N.; Zipfel, S.; Herzog, W.; Herpertz-Dahlmann, B.; Klampfl, K.; Fleischhaker, C.; Zeeck, A.; Zwaan, M.; Herpertz, S.; Ehrlich, S.; van Elburg, A.A.; Adan, R.A.H.; Scherag, S.; Hinney, A.; Hebebrand, J.; Boomsma, D.I.; van Furth, E.F.; Slagboom, P.E.

2011-01-01

Twin studies suggest that genetic factors play a substantial role in anorexia nervosa (AN) and self-induced vomiting (SV), a key symptom that is shared among different types of eating disorders (EDs). We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of

Association study in eating disorders : TPH2 associates with anorexia nervosa and self-induced vomiting

NARCIS (Netherlands)

't Landt, M. C. T. Slof-Op; Meulenbelt, I.; Bartels, M.; Suchiman, E.; Middeldorp, C. M.; Houwing-Duistermaat, J. J.; van Trier, J.; Onkenhout, E. J.; Vink, J. M.; van Beijsterveldt, C. E. M.; Brandys, M. K.; Sanders, N.; Zipfel, S.; Herpertz-Dahlmann, B.; Klampfl, K.; Fleischhaker, C.; Zeeck, A.; de Zwaan, M.; Herpertz, S.; Ehrlich, S.; van Elburg, A. A.; Adan, R. A. H.; Scherag, S.; Hinney, A.; Hebebrand, J.; Boomsma, D. I.; van Furth, E. F.; Slagboom, P. E.; Herzog, W.

Twin studies suggest that genetic factors play a substantial role in anorexia nervosa (AN) and self-induced vomiting (SV), a key symptom that is shared among different types of eating disorders (EDs). We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of

Deformation-induced martensite and resistance to cavitation erosion

International Nuclear Information System (INIS)

Richman, R.H.

1995-01-01

Exposure to cavitating liquids can induce surface transformation in metastable alloys, notably the 18Cr-8Ni class of stainless steels. The question of whether such transformation contributes to erosion resistance has not been resolved. To address that issue, two metastable stainless steels (Types 301 and 304L) and a near-equiatomic NiTi alloy were subjected to cavitation. Magnetic measurements during and after cavitation erosion indicate that substantial reversion of deformation-induced martensite occurs in the highly deformed surface layers of the stainless steels. Thus, cyclic formation and reversion of martensite is deduced to be a non-trivial energy-adsorption mechanism in those steels. The extreme case of cyclic induction and essentially complete reversion of martensite is illustrated by superelastic NiTi, which is extraordinarily resistant to cavitation damage. (orig.)

Reducing errors benefits the field-based learning of a fundamental movement skill in children.

Science.gov (United States)

Capio, C M; Poolton, J M; Sit, C H P; Holmstrom, M; Masters, R S W

2013-03-01

Proficient fundamental movement skills (FMS) are believed to form the basis of more complex movement patterns in sports. This study examined the development of the FMS of overhand throwing in children through either an error-reduced (ER) or error-strewn (ES) training program. Students (n = 216), aged 8-12 years (M = 9.16, SD = 0.96), practiced overhand throwing in either a program that reduced errors during practice (ER) or one that was ES. ER program reduced errors by incrementally raising the task difficulty, while the ES program had an incremental lowering of task difficulty. Process-oriented assessment of throwing movement form (Test of Gross Motor Development-2) and product-oriented assessment of throwing accuracy (absolute error) were performed. Changes in performance were examined among children in the upper and lower quartiles of the pretest throwing accuracy scores. ER training participants showed greater gains in movement form and accuracy, and performed throwing more effectively with a concurrent secondary cognitive task. Movement form improved among girls, while throwing accuracy improved among children with low ability. Reduced performance errors in FMS training resulted in greater learning than a program that did not restrict errors. Reduced cognitive processing costs (effective dual-task performance) associated with such approach suggest its potential benefits for children with developmental conditions. © 2011 John Wiley & Sons A/S.

3D, Flash, Induced Current Readout for Silicon Sensors

Energy Technology Data Exchange (ETDEWEB)

Parker, Sherwood I. [Univ. of Hawaii, Honolulu, HI (United States)

2014-06-07

A new method for silicon microstrip and pixel detector readout using (1) 65 nm-technology current amplifers which can, for the first time with silicon microstrop and pixel detectors, have response times far shorter than the charge collection time (2) 3D trench electrodes large enough to subtend a reasonable solid angle at most track locations and so have adequate sensitivity over a substantial volume of pixel, (3) induced signals in addition to, or in place of, collected charge

26 CFR 1.6662-5T - Substantial and gross valuation misstatements under chapter 1 (temporary).

Science.gov (United States)

2010-04-01

..., DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Additions to the Tax, Additional... persons). (iii) Property. For purposes of this section, the term property refers to both tangible and... adjustments. For rules relating to the penalty imposed with respect to a substantial or gross valuation...

75 FR 69454 - Emergency Homeowners' Loan Program: Notice of Allocation of Funding for Substantially Similar...

Science.gov (United States)

2010-11-12

... assistance and provide security for such repayment by recordation of a HUD mortgage as a junior lien on the... current first lien mortgage loan payments for which the homeowner remains responsible. IV. Submission of.... Nondiscrimination and Civil Rights Requirements States operating existing programs that provide substantially...

What would happen to Superstorm Sandy under the influence of a substantially warmer Atlantic Ocean?

Science.gov (United States)

Lau, William K. M.; Shi, J. J.; Tao, W. K.; Kim, K. M.

2016-01-01

Based on ensemble numerical simulations, we find that possible responses of Sandy-like superstorms under the influence of a substantially warmer Atlantic Ocean bifurcate into two groups. In the first group, storms are similar to present-day Sandy from genesis to extratropical transition, except they are much stronger, with peak Power Destructive Index (PDI) increased by 50-80%, heavy rain by 30-50%, and maximum storm size (MSS) approximately doubled. In the second group, storms amplify substantially over the interior of the Atlantic warm pool, with peak PDI increased by 100-160%, heavy rain by 70-180%, and MSS more than tripled compared to present-day Superstorm Sandy. These storms when exiting the warm pool, recurve northeastward out to sea, subsequently interact with the developing midlatitude storm by mutual counterclockwise rotation around each other and eventually amplify into a severe Northeastern coastal storm, making landfall over the extreme northeastern regions from Maine to Nova Scotia.

Substantiating the Expediency of Costs on Introduction of the System of Economic Security of Enterprise

Directory of Open Access Journals (Sweden)

Melikhova Tetiana O.

2018-01-01

Full Text Available The article substantiates expediency of introduction of the system of economic security of enterprise on the basis of money flows. The methods proposed in the long-term period stipulate the use as sources of financing: accumulated conditional economic costs, accumulated conditional gross and net money flow; and as costs: cumulative advanced costs and the advanced value of fixed assets. The article suggests methods for calculation of: gross index of conditional yield; gross conditional income of project; gross conditional profitability; gross conditional profitability of money flow. The managerial decision on introduction of the system of economic security of enterprise in the short-term production period has been substantiated on the basis of calculations of the following indicators: gross profitability of annual depreciation; annual gross economic effect; index of conditional yield of the gross money flow; differences between the conditional gross cash flow and the depreciation deductions associated with the implementation of the enterprise’s economic security system.

Examination of Automation-Induced Complacency and Individual Difference Variates

Science.gov (United States)

Prinzel, Lawrence J., III; DeVries, Holly; Freeman, Fred G.; Mikulka, Peter

2001-01-01

Automation-induced complacency has been documented as a cause or contributing factor in many airplane accidents throughout the last two decades. It is surmised that the condition results when a crew is working in highly reliable automated environments in which they serve as supervisory controllers monitoring system states for occasional automation failures. Although many reports have discussed the dangers of complacency, little empirical research has been produced to substantiate its harmful effects on performance as well as what factors produce complacency. There have been some suggestions, however, that individual characteristics could serve as possible predictors of performance in automated systems. The present study examined relationship between the individual differences of complacency potential, boredom proneness, and cognitive failure, automation-induced complacency. Workload and boredom scores were also collected and analyzed in relation to the three individual differences. The results of the study demonstrated that there are personality individual differences that are related to whether an individual will succumb to automation-induced complacency. Theoretical and practical implications are discussed.

Effect of dose on radiation-induced conductivity in polymers

International Nuclear Information System (INIS)

Tyutnev, A.P.; Saenko, V.S.; Pozhidaev, E.D.; Ikhsanov, R.Sh.

2007-01-01

Numerical simulation of radiation-induced conductivity in polymers upon long-term irradiation on the basis of the generalized Rose-Fowler-Vaisberg model, which allows for both dipolar carrier transport and generation of radiation traps during irradiation, was performed. The unusual properties of radiation-induced conductivity, such as the appearance of a maximum on current transients, the absence of a steady state, and a substantial difference between these curves for the first and subsequent irradiation, are rationalized in terms of the formation of free radicals, the major feature of radiolysis in the chemical aspect. This interpretation does not require the involvement of degradation or crosslinking processes, unlike other interpretations that appear in the literature. With the use of low-density polyethylene as an example, it was shown that radiation-induced conductivity both upon pulse and continuous irradiation can satisfactorily be described with the unified set of parameters of the generalized Rose-Fowler-Vaisberg model [ru

To what extent can isotopes help substantiate natural attenuation of chlorinated ethenes?

DEFF Research Database (Denmark)

Badin, A.; Broholm, Mette Martina; Hunkeler, D.

to which isotopes could help substantiate natural attenuation of chlorinated ethenes at the field scale. Our work hence aims at exploring the latter based on data acquired in 2006 in a site located in Denmark which is contaminated with PCE and its end-products TCE, cDCE, and VC. Previous work on this site...... has enabled to demonstrate that PCE and TCE were undergoing reductive dechlorination while cDCE would be at least partially degraded through reductive dechlorination1. However, the magnitude of the contaminants attenuation by biodegradation was not evaluated. Based on simple modeling including...

34 CFR 692.41 - What standards may a State use to determine substantial financial need?

Science.gov (United States)

2010-07-01

... PARTNERSHIP PROGRAM Leveraging Educational Assistance Partnership Program How Does A State Select Students... establishes that are approved by the Secretary. A State may define substantial financial need in terms of... “independent student” as defined under section 480(d) of the HEA. However, for good cause shown, the Secretary...

An artificial neural network approach to laser-induced breakdown spectroscopy quantitative analysis

International Nuclear Information System (INIS)

D’Andrea, Eleonora; Pagnotta, Stefano; Grifoni, Emanuela; Lorenzetti, Giulia; Legnaioli, Stefano; Palleschi, Vincenzo; Lazzerini, Beatrice

2014-01-01

The usual approach to laser-induced breakdown spectroscopy (LIBS) quantitative analysis is based on the use of calibration curves, suitably built using appropriate reference standards. More recently, statistical methods relying on the principles of artificial neural networks (ANN) are increasingly used. However, ANN analysis is often used as a ‘black box’ system and the peculiarities of the LIBS spectra are not exploited fully. An a priori exploration of the raw data contained in the LIBS spectra, carried out by a neural network to learn what are the significant areas of the spectrum to be used for a subsequent neural network delegated to the calibration, is able to throw light upon important information initially unknown, although already contained within the spectrum. This communication will demonstrate that an approach based on neural networks specially taylored for dealing with LIBS spectra would provide a viable, fast and robust method for LIBS quantitative analysis. This would allow the use of a relatively limited number of reference samples for the training of the network, with respect to the current approaches, and provide a fully automatizable approach for the analysis of a large number of samples. - Highlights: • A methodological approach to neural network analysis of LIBS spectra is proposed. • The architecture of the network and the number of inputs are optimized. • The method is tested on bronze samples already analyzed using a calibration-free LIBS approach. • The results are validated, compared and discussed

CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain

NARCIS (Netherlands)

Krukowski, Karen; Eijkelkamp, Niels; Laumet, Geoffroy; Hack, C Erik; Li, Yan; Dougherty, Patrick M; Heijnen, Cobi J; Kavelaars, Annemieke

2016-01-01

Chemotherapy-induced peripheral neuropathy (CIPN), characterized by pain and numbness in hands and feet, is a common side effect of cancer treatment. In most patients, symptoms of CIPN subside after treatment completion. However, in a substantial subgroup, CIPN persists long into survivorship.

Hormone-induced protection against mammary tumorigenesis is conserved in multiple rat strains and identifies a core gene expression signature induced by pregnancy.

Science.gov (United States)

Blakely, Collin M; Stoddard, Alexander J; Belka, George K; Dugan, Katherine D; Notarfrancesco, Kathleen L; Moody, Susan E; D'Cruz, Celina M; Chodosh, Lewis A

2006-06-15

Women who have their first child early in life have a substantially lower lifetime risk of breast cancer. The mechanism for this is unknown. Similar to humans, rats exhibit parity-induced protection against mammary tumorigenesis. To explore the basis for this phenomenon, we identified persistent pregnancy-induced changes in mammary gene expression that are tightly associated with protection against tumorigenesis in multiple inbred rat strains. Four inbred rat strains that exhibit marked differences in their intrinsic susceptibilities to carcinogen-induced mammary tumorigenesis were each shown to display significant protection against methylnitrosourea-induced mammary tumorigenesis following treatment with pregnancy levels of estradiol and progesterone. Microarray expression profiling of parous and nulliparous mammary tissue from these four strains yielded a common 70-gene signature. Examination of the genes constituting this signature implicated alterations in transforming growth factor-beta signaling, the extracellular matrix, amphiregulin expression, and the growth hormone/insulin-like growth factor I axis in pregnancy-induced alterations in breast cancer risk. Notably, related molecular changes have been associated with decreased mammographic density, which itself is strongly associated with decreased breast cancer risk. Our findings show that hormone-induced protection against mammary tumorigenesis is widely conserved among divergent rat strains and define a gene expression signature that is tightly correlated with reduced mammary tumor susceptibility as a consequence of a normal developmental event. Given the conservation of this signature, these pathways may contribute to pregnancy-induced protection against breast cancer.

Pre-equilibrium emission of nucleons from reactions induced by medium-energy heavy ions

International Nuclear Information System (INIS)

Korolija, M.; Holuh, E.; Cindro, N.; Hilscher, D.

1984-01-01

Recent data on fast-nucleon emission in heavy-ion-induced reactions are analysed successfully in terms of pre-equilibrium models; it is shown that the relevant parameters of those models preserve the physical meaning they have in light-ion-induced reactions. The initial exciton number obtained from a Griffin-plot analysis and the initial number of degrees of freedom, which is the relevant parameter of the modified HMB model, appear to be approximately equal for a given reaction at a given energy. It is inferred that, for heavy-ion reactions, the determination of such a parameter is substantially dominated by the centre-of-mass energy per nucleon above the Coulomb barrier, in contrast with the results of nucleon-induced reactions

Substantial Fatigue Similarity of a New Small-Scale Test Rig to Actual Wheel-Rail System

NARCIS (Netherlands)

Naeimi, M.; Li, Z.; Petrov, R.H.; Dollevoet, R.P.B.J.; Sietsma, J.; Wu, J.

2014-01-01

The substantial similarity of fatigue mechanism in a new test rig for rolling contact fatigue (RCF) has been investigated. A new reduced-scale test rig is designed to perform controlled RCF tests in wheel-rail materials. The fatigue mechanism of the rig is evaluated in this study using a combined

Redefining transfusion-related acute lung injury: don't throw the baby out with the bathwater.

Science.gov (United States)

Peters, Anna L; Vlaar, Alexander P J

2016-09-01

Recently two articles have been published in TRANSFUSION in which the authors propose to change the current definition on transfusion-related acute lung injury (TRALI). It was proposed to view TRALI from the perspective of detectability versus nondetectability of leukoreactive alloantibodies (Transfusion 2015;55:1128-34). The authors argue that only cases in which leukoreactive alloantibodies can be detected should be defined as "true" TRALI in analogy with the understanding of the pathophysiology of heparin-induced thrombocytopenia. In the other article (Transfusion 2015;55:947-52), the authors propose to redefine possible TRALI to transfused acute respiratory distress syndrome (ARDS) as their study in intensive care unit patients did not show a relation between the number of transfusions and possible TRALI.We discuss these two propositions in light of the current evidence on pathophysiology of TRALI and possible TRALI. We argue that it is too early to redefine TRALI, as 1) factors, such as storage time of platelets, which induce TRALI in preclinical studies, have not yet been properly investigated in humans. Further research is needed on these agents before it is concluded that antibody-mediated TRALI is the only "true" TRALI. 2) In light of the current knowledge, it makes perfect sense that multiple transfusion is not related to possible TRALI: ARDS risk factors in these patients result in a very sensitive equilibrium in which even only one transfusion induces TRALI. Excluding possible TRALI from the TRALI definition would result in further underrecognition of TRALI induced by alloantibodies and interferes with exclusion of donors related to TRALI cases and thus TRALI prevention. © 2016 AABB.

Monte Carlo reactor calculation with substantially reduced number of cycles

International Nuclear Information System (INIS)

Lee, M. J.; Joo, H. G.; Lee, D.; Smith, K.

2012-01-01

A new Monte Carlo (MC) eigenvalue calculation scheme that substantially reduces the number of cycles is introduced with the aid of coarse mesh finite difference (CMFD) formulation. First, it is confirmed in terms of pin power errors that using extremely many particles resulting in short active cycles is beneficial even in the conventional MC scheme although wasted operations in inactive cycles cannot be reduced with more particles. A CMFD-assisted MC scheme is introduced as an effort to reduce the number of inactive cycles and the fast convergence behavior and reduced inter-cycle effect of the CMFD assisted MC calculation is investigated in detail. As a practical means of providing a good initial fission source distribution, an assembly based few-group condensation and homogenization scheme is introduced and it is shown that efficient MC eigenvalue calculations with fewer than 20 total cycles (including inactive cycles) are possible for large power reactor problems. (authors)

Induced pluripotent stem cells (iPSC)-derived retinal cells in disease modeling and regenerative medicine.

Science.gov (United States)

Rathod, Reena; Surendran, Harshini; Battu, Rajani; Desai, Jogin; Pal, Rajarshi

2018-02-12

Retinal degenerative disorders are a leading cause of the inherited, irreversible and incurable vision loss. While various rodent model systems have provided crucial information in this direction, lack of disease-relevant tissue availability and species-specific differences have proven to be a major roadblock. Human induced pluripotent stem cells (iPSC) have opened up a whole new avenue of possibilities not just in understanding the disease mechanism but also potential therapeutic approaches towards a cure. In this review, we have summarized recent advances in the methods of deriving retinal cell types from iPSCs which can serve as a renewable source of disease-relevant cell population for basic as well as translational studies. We also provide an overview of the ongoing efforts towards developing a suitable in vitro model for modeling retinal degenerative diseases. This basic understanding in turn has contributed to advances in translational goals such as drug screening and cell-replacement therapies. Furthermore we discuss gene editing approaches for autologous repair of genetic disorders and allogeneic transplantation of stem cell-based retinal derivatives for degenerative disorders with an ultimate goal to restore vision. It is pertinent to note however, that these exciting new developments throw up several challenges that need to be overcome before their full clinical potential can be realized. Copyright © 2018 Elsevier B.V. All rights reserved.

Structural and defects induced phenomena in γ-rays irradiated 6H-SiC

International Nuclear Information System (INIS)

Sibuyi, P.; Ngom, B.D.; Kotsedi, L.

2016-01-01

Damages and/or defects induced by γ-rays irradiation on 6H-SiC single crystals in channeled configuration towards 〈006〉/〈0012〉 crystallographic directions are reported in the range of 0–1200 kGy. Atomic force microscopy, X-rays diffraction, Raman and photoluminescence investigations were used to obtain a comprehensive set of informations on the nature and population distribution of the induced defects. Primarily, there was no carbon clusterization upon γ-rays irradiation and hence no formation of others SiC polytypes. In contrast, the γ-rays irradiation has induced an increase of the surface roughness at higher doses, which indicates a structural degradation. Larger doses induced an emergence of deeper shallow traps at energies greater than 350 meV below the bandgap. - Highlights: • No formation of others SiC polytypes. • The gamma rays irradiation has induced a slight surface amorphization. • A re-crystallization at lower and higher doses is noticed. • Larger doses induced a substantial internal stress.

Imaging femtosecond laser-induced electronic excitation in glass

International Nuclear Information System (INIS)

Mao Xianglei; Mao, Samuel S.; Russo, Richard E.

2003-01-01

While substantial progress has been achieved in understanding laser ablation on the nanosecond and picosecond time scales, it remains a considerable challenge to elucidate the underlying mechanisms during femtosecond laser material interactions. We present experimental observations of electronic excitation inside a wide band gap glass during single femtosecond laser pulse (100 fs, 800 nm) irradiation. Using a femtosecond time-resolved imaging technique, we measured the evolution of a laser-induced electronic plasma inside the glass and calculated the electron number density to be on the order of 10 19 cm -3

An unknown oxidative metabolism substantially contributes to soil CO2 emissions

Directory of Open Access Journals (Sweden)

T. Shahzad

2013-02-01

Full Text Available The respiratory release of CO2 from soils is a major determinant of the global carbon cycle. It is traditionally considered that this respiration is an intracellular metabolism consisting of complex biochemical reactions carried out by numerous enzymes and co-factors. Here we show that the endoenzymes released from dead organisms are stabilised in soils and have access to suitable substrates and co-factors to permit function. These enzymes reconstitute an extracellular oxidative metabolism (EXOMET that may substantially contribute to soil respiration (16 to 48% of CO2 released from soils in the present study. EXOMET and respiration from living organisms should be considered separately when studying effects of environmental factors on the C cycle because EXOMET shows specific properties such as resistance to high temperature and toxic compounds.

Characteristics of Induced Abortion in China in the 1990s

Institute of Scientific and Technical Information of China (English)

Xiao-chun QIAO

2007-01-01

Objective To understand the characteristics of induced abortion in China in the 1990s,and to find out the influential factors.Methods The overall number of induced abortions, calculate cohort induced abortion frequency, explore the impact of a child's sex and the number of previous children on induced abortions were estimated by using the data from the "National Population and Reproductive Health Survey" conducted by the National Family Planning Commission in November 1997.Results Induced abortions in China had their own characteristics, which were far different from other countries. The main difference was led by the fact that the country was driven by an implemented family planning program and nationwide population policies. The key cause of induced abortions was due to an inconsistency with the requirements of the family planning policy. However, as a result of effective and prevalent contraception, the rates of induced abortions were not quite high in the 1990s,when compared with other countries. Even though, in the early 1990s, the government had reinforced the family planning program through administration and legislation,unlike during the early 1980s when the one-child policy was implemented, the induced abortion rate and the number of induce abortions did not increase as the fertility rate substantially decreased.Concltsion This finding implies that the fertility declines in the 1990s were not caused by the number of induced abortions. The transition of the fertility ideology of the people has played an important role in the fertility decline, as institutional reform and socioeconomic development are implemented.

Effects induced by γ-radiation on the noise in junction field-effect transistors belonging to monolithic processes

International Nuclear Information System (INIS)

Manfredi, P.F.; Re, V.; Manfredi, P.F.; Speziali, V.; Re, V.; Manfredi, P.F.; Speziali, V.

1999-01-01

The effects of γ-rays on the noise characteristics of junction field-effect transistors belonging to three monolithic technologies have been investigated. A substantially different behavior of the radiation-induced noise in N and P -channel JFETs was observed. This may result in interesting design considerations. (authors)

Effect of top electrode material on radiation-induced degradation of ferroelectric thin film structures

Energy Technology Data Exchange (ETDEWEB)

Brewer, Steven J.; Bassiri-Gharb, Nazanin [G.W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 (United States); School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 (United States); Deng, Carmen Z.; Callaway, Connor P. [School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 (United States); Paul, McKinley K. [G.W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 (United States); Woodward Academy, College Park, Georgia 30337 (United States); Fisher, Kenzie J. [G.W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 (United States); Riverwood International Charter School, Atlanta, Georgia 30328 (United States); Guerrier, Jonathon E.; Jones, Jacob L. [Department of Materials Science and Engineering, North Carolina State University, Raleigh, North Carolina 27695 (United States); Rudy, Ryan Q.; Polcawich, Ronald G. [Army Research Laboratory, Adelphi, Maryland 20783 (United States); Glaser, Evan R.; Cress, Cory D. [Naval Research Laboratory, Washington, DC 20375 (United States)

2016-07-14

The effects of gamma irradiation on the dielectric and piezoelectric responses of Pb[Zr{sub 0.52}Ti{sub 0.48}]O{sub 3} (PZT) thin film stacks were investigated for structures with conductive oxide (IrO{sub 2}) and metallic (Pt) top electrodes. The samples showed, generally, degradation of various key dielectric, ferroelectric, and electromechanical responses when exposed to 2.5 Mrad (Si) {sup 60}Co gamma radiation. However, the low-field, relative dielectric permittivity, ε{sub r}, remained largely unaffected by irradiation in samples with both types of electrodes. Samples with Pt top electrodes showed substantial degradation of the remanent polarization and overall piezoelectric response, as well as pinching of the polarization hysteresis curves and creation of multiple peaks in the permittivity-electric field curves post irradiation. The samples with oxide electrodes, however, were largely impervious to the same radiation dose, with less than 5% change in any of the functional characteristics. The results suggest a radiation-induced change in the defect population or defect energy in PZT with metallic top electrodes, which substantially affects motion of internal interfaces such as domain walls. Additionally, the differences observed for stacks with different electrode materials implicate the ferroelectric–electrode interface as either the predominant source of radiation-induced effects (Pt electrodes) or the site of healing for radiation-induced defects (IrO{sub 2} electrodes).

Bowel injuries secondary to induced abortion: a dilemma

International Nuclear Information System (INIS)

Rehman, A.; Fatima, S.; Soomro, N.

2006-01-01

To study the pattern of bowel injuries incurred by induced abortion, and the morbidity and mortality associated with them. All patients with bowel injuries due to induced abortion. Detailed data of all the patients was collected and analyzed. A total of 22 patients, mostly young with an average age of 26.86 years, presented with bowel injuries following induced abortion. Severe hemorrhage occurred in 8(36.4%) patients while 11(50%) had ileal perforation; 9(40.9%) underwent primary repair and 2(9.1%) ileostomy formation. Two (9.1%) patients with jejunal perforation had primary repair, whereas two with both jejunal and ileal perforations underwent resections with anastomosis in one and ileostomy in another. Seven (31.8%) with large gut involvement had colostomy formation. Septicemia and wound infection occurred in 7(31.8%) patients each, faecal fistula and abdominal wound dehiscence in 3(13.6%), and pelvic abscess in 1(4.6%) patient. The total mortality in this series was 6(27.3%) patients. Iatrogenic injuries during induced abortion, most commonly caused by quacks, can be minimized substantially if the procedure is performed by qualified medical personnel in proper health care facilities. There is a need for radical overhauling of the mind set in our society together with legislation. (author)

Early evaluation of patient risk for substantial weight gain during olanzapine treatment for schizophrenia, schizophreniform, or schizoaffective disorder

Directory of Open Access Journals (Sweden)

Hardy Thomas A

2008-09-01

Full Text Available Abstract Background To make well informed treatment decisions for their patients, clinicians need credible information about potential risk for substantial weight gain. We therefore conducted a post-hoc analysis of clinical trial data, examining early weight gain as a predictor of later substantial weight gain. Methods Data from 669 (Study 1 and 102 (Study 2 olanzapine-treated patients diagnosed with schizophrenia, schizophreniform, or schizoaffective disorder were analyzed to identify and validate weight gain cut-offs at Weeks 1–4 that were predictive of substantial weight gain (defined as an increase of ≥ 5, 7, 10 kg or 7% of baseline weight after approximately 30 weeks of treatment. Baseline characteristics alone, baseline characteristics plus weight change from baseline to Weeks 1, 2, 3 or 4, and weight change from baseline to Weeks 1, 2, 3, or 4 alone were evaluated as predictors of substantial weight gain. Similar analyses were performed to determine BMI increase cut-offs at Weeks 1–4 of treatment that were predictive of substantial increase in BMI (1, 2 or 3 kg/m2 increase from baseline. Results At Weeks 1 and 2, predictions based on early weight gain plus baseline characteristics were more robust than those based on early weight gain alone. However, by Weeks 3 and 4, there was little difference between the operating characteristics associated with these two sets of predictors. The positive predictive values ranged from 30.1% to 73.5%, while the negative predictive values ranged from 58.1% to 89.0%. Predictions based on early BMI increase plus baseline characteristics were not uniformly more robust at any time compared to those based on early BMI increase alone. The positive predictive values ranged from 38.3% to 83.5%, while negative predictive values ranged from 42.1% to 84.7%. For analyses of both early weight gain and early BMI increase, results for the validation dataset were similar to those observed in the primary dataset

Surface modification of silica nanoparticles by UV-induced graft polymerization of methyl methacrylate.

Science.gov (United States)

Kim, Sooyeon; Kim, Eunhye; Kim, Sungsoo; Kim, Woosik

2005-12-01

In this study we modified the surface of silica nanoparticles with methyl methacrylate by UV-induced graft polymerization. It is a surface-initiated polymerization reaction induced by ultraviolet irradiation. The resulting organic-inorganic nanocomposites were near-monodisperse and fabricated without homopolymerization of the monomer. Substantial increase in mean particle size was observed by SEM image analysis after UV-induced grafting of methyl methacrylate onto pure silica particles. FT-Raman spectroscopy and X-ray photoelectron spectroscopy studies of these materials revealed the successful grafting of methyl methacrylate onto the silica surface. The formation of a covalent bond between the grafted PMMA chains and silica surface was indicated by FT-Raman spectra. Thermogravimetric analysis of the PMMA-grafted silica particles indicated the polymer contents in good agreement with SEM photographs.

Effect of upper body plyometric training on physical performance in healthy individuals: A systematic review.

Science.gov (United States)

Singla, Deepika; Hussain, M Ejaz; Moiz, Jamal Ali

2018-01-01

To determine the impact of upper body plyometric training (UBPT) on physical performance parameters such as strength, ball throwing speed, ball throw distance and power in healthy individuals. PubMed, Scopus, ResearchGate and ERIC databases were searched up to August 2017. Selection of articles was done if they described the outcomes of an upper body plyometric exercise intervention; included measures of strength, ball throwing speed, ball throw distance, or power; included healthy individuals; used a randomized control trial; and had full text available in English language. The exclusion criteria were unpublished research work and clubbing of UBPT with some other type(s) of training apart from routine sports training. PEDro scale was used to rate the quality of studies eligible for this review. Initially 264 records were identified and out of them only 11 articles met the eligibility criteria and were selected (PEDro score = 4 to 6). Though large to very small effects observed in improving ball throwing velocity, ball throwing distance, power and strength of upper limb muscles after UBPT, the results should be implemented with caution. Inconclusive results obtained preclude any strong conclusion regarding the efficacy of UBPT on physical performance in healthy individuals. Copyright © 2017 Elsevier Ltd. All rights reserved.

Technique of Substantiating Requirements for the Vision Systems of Industrial Robotic Complexes

Directory of Open Access Journals (Sweden)

V. Ya. Kolyuchkin

2015-01-01

Full Text Available In references, there is a lack of approaches to describe the justified technical requirements for the vision systems (VS of industrial robotics complexes (IRC. Therefore, an objective of the work is to develop a technique that allows substantiating requirements for the main quality indicators of VS, functioning as a part of the IRC.The proposed technique uses a model representation of VS, which, as a part of the IRC information system, sorts the objects in the work area, as well as measures their linear and angular coordinates. To solve the problem of statement there is a proposal to define the target function of a designed IRC as a dependence of the IRC indicator efficiency on the VS quality indicators. The paper proposes to use, as an indicator of the IRC efficiency, the probability of a lack of fault products when manufacturing. Based on the functions the VS perform as a part of the IRC information system, the accepted indicators of VS quality are as follows: a probability of the proper recognition of objects in the working IRC area, and confidential probabilities of measuring linear and angular orientation coordinates of objects with the specified values of permissible error. Specific values of these errors depend on the orientation errors of working bodies of manipulators that are a part of the IRC. The paper presents mathematical expressions that determine the functional dependence of the probability of a lack of fault products when manufacturing on the VS quality indicators and the probability of failures of IRC technological equipment.The offered technique for substantiating engineering requirements for the VS of IRC has novelty. The results obtained in this work can be useful for professionals involved in IRC VS development, and, in particular, in development of VS algorithms and software.

Role of CTA1R7K-COL-DD as a novel therapeutic mucosal tolerance-inducing vector for treatment of collagen-induced arthritis.

Science.gov (United States)

Hasselberg, Annemarie; Schön, Karin; Tarkowski, Andrej; Lycke, Nils

2009-06-01

To determine whether a cholera toxin-derived, novel immunomodulating fusion protein, CTA1R7K-COL-DD, carrying the class II major histocompatibility complex H-2q-restricted type II collagen peptide aa 259-274, can induce therapeutic tolerance and prevent collagen-induced arthritis (CIA) when administered intranasally in DBA/1 mice, and to assess whether ADP-ribosylation at the mucosal membranes exerts a regulatory function such that the outcome of tolerance or immune enhancement can be controlled. DBA/1 mice with CIA were treated intranasally with CTA1R7K-COL-DD. The therapeutic effect was monitored for 46 days after the onset of disease. Clinical scoring of disease, histologic examination of inflammation, and bone erosion were assessed, and cytokine levels were determined in the serum or supernatants from splenocytes stimulated with recall antigen. The protective effect of CTA1R7K-COL-DD resulted in roughly 60% of the mice having no clinical signs or histologic evidence of disease after treatment, and those with CIA had significantly milder disease with less bone erosion. The protective status was associated with lower serum titers of IgG1, IgG2a, IgG2b, and IgG3 anticollagen and a substantial decrease in the production of interleukin-6 (IL-6), IL-17, and interferon-gamma, while levels of IL-10 were markedly up-regulated both in the serum and at the T cell level. The enzymatically inactive mutant fusion protein CTA1R7K-COL-DD provided substantial therapeutic protection against CIA following intranasal administration. The mechanism behind the effect appears to be mediated by peptide-specific regulatory T cells induced by mucosal exposure to the peptide containing CTA1R7K-COL-DD vector. In addition, ADP-ribosylation at the mucosal membranes acts as a key regulator controlling mucosal tolerance or immunity.

Pentosan-derived water-soluble carbon nano dots with substantial fluorescence: Properties and application as a photosensitizer

Science.gov (United States)

Wu, Qiong; Li, Wei; Wu, Yanjiao; Huang, Zhanhua; Liu, Shouxin

2014-10-01

The hydrothermal carbonization of monosaccharides and polysaccharides is widely used in the production of carbonaceous material with a desired structure. However, the liquid products are regarded as waste and discarded. Here, we report a facile approach for the synthesis of water-soluble carbon nano dots (CNDs) with substantial fluorescence from the liquid by-products of the hydrothermal carbonization of pentosan, thus the by-products of pulp refining. The synthesized CNDs are monodispersed spheres with abundant oxygen-containing groups and they have an average size of 30 nm. Quantum yield measurements revealed CNDs with substantial green photoluminescence (PL) without passivation. Additionally, excitation was independent, pH-sensitive and stable. The use of CNDs as a photosensitizer in the CNDs/TiO2 system for methylene blue (MB) degradation under visible light irradiation is attractive. The spectral response range of the CNDs/TiO2 system can be widened from the UV region to a part of the visible light region (400-550 nm).

[From Bonghan system to primo vascular system:the thought on the substantial study on meridian points].

Science.gov (United States)

Lin, Dong; Huang, Xiaozhen; Zhuang, Wanyu; Lin, Lili

2017-01-12

Through the systematic analysis on the primo vascular system (PVS) in recent years, we believe that in recent years, more and more studies have indicated that PVS is distributed in reticulate structure in every part of body, such as vessels, lymphangions, nerves, brain, spinal cords and internal organs, and it contains a large amount of immunocytes and has involved in the physiological or pathological process of the immunity and circulation in the body. There are the evidences to prove that in morphology and cytobiology. But, nowadays, there is no way to explain its effect characters. On the basis of the study on living matter characteristics, a breakthrough is possibly made through the systematic cooperation even though it is the difficulty to detect the life function effect. It is especially displayed in the substantial study on meridian points. Hence, the study on the law of meridian point effects on the basis of clinical practice has to be focused on in the substantial study on meridian points.

Complex researches on substantiation of construction and seismic stability of large dams in seismic region

International Nuclear Information System (INIS)

Negmatullaev, S.Kh.; Yasunov, P.A.

2001-01-01

This article is devoted to complex researches on substantiation of construction and seismic stability of large dams (Nurec hydroelectric power station) in seismic region. Geological, seismological, model, and engineering investigations are discussed in this work. At construction of Nurec hydroelectric power station the rich experience is accumulated. This experience can be used in analogous seismically active regions at construction similar hydroelectric power stations.

Complementary sex determination substantially increases extinction proneness of haplodiploid populations.

Science.gov (United States)

Zayed, Amro; Packer, Laurence

2005-07-26

The role of genetic factors in extinction is firmly established for diploid organisms, but haplodiploids have been considered immune to genetic load impacts because deleterious alleles are readily purged in haploid males. However, we show that single-locus complementary sex determination ancestral to the haplodiploid Hymenoptera (ants, bees, and wasps) imposes a substantial genetic load through homozygosity at the sex locus that results in the production of inviable or sterile diploid males. Using stochastic modeling, we have discovered that diploid male production (DMP) can initiate a rapid and previously uncharacterized extinction vortex. The extinction rate in haplodiploid populations with DMP is an order of magnitude greater than in its absence under realistic but conservative demographic parameter values. Furthermore, DMP alone can elevate the base extinction risk in haplodiploids by over an order of magnitude higher than that caused by inbreeding depression in threatened diploids. Thus, contrary to previous expectations, haplodiploids are more, rather than less, prone to extinction for genetic reasons. Our findings necessitate a fundamental shift in approaches to the conservation and population biology of these ecologically and economically crucial insects.

Transfer of memory trace of cerebellum-dependent motor learning in human prism adaptation: a model study.

Science.gov (United States)

Nagao, Soichi; Honda, Takeru; Yamazaki, Tadashi

2013-11-01

Accumulating experimental evidence suggests that the memory trace of ocular reflex adaptation is initially encoded in the cerebellar cortex, and later transferred to the cerebellar nuclei for consolidation through repetitions of training. However, the memory transfer is not well characterized in the learning of voluntary movement. Here, we implement our model of memory transfer to interpret the data of prism adaptation (Martin, Keating, Goodkin, Bastian, & Thach, 1996a, 1996b), assuming that the cerebellar nuclear memory formed by memory transfer is used for normal throwing. When the subject was trained to throw darts wearing prisms in 30-40 trials, the short-term memory for recalibrating the throwing direction by gaze would be formed in the cerebellar cortex, which was extinguished by throwing with normal vision in a similar number of trials. After weeks of repetitions of short-term prism adaptation, the long-term memory would be formed in the cerebellar nuclei through memory transfer, which enabled one to throw darts to the center wearing prisms without any training. These two long-term memories, one for throwing with normal vision and the other for throwing wearing prisms, are assumed to be utilized automatically under volitional control. Moreover, when the prisms were changed to new prisms, a new memory for adapting to the new prisms would be formed in the cerebellar cortex, just to counterbalance the nuclear memory of long-term adaptation to the original prisms in a similar number of trials. These results suggest that memory transfer may occur in the learning of voluntary movements. Copyright © 2013 Elsevier Ltd. All rights reserved.

76 FR 41424 - Finding of Substantial Inadequacy of Implementation Plan; Call for Iowa State Implementation Plan...

Science.gov (United States)

2011-07-14

... modeling requirement for this SIP call should allow for the use of the modeling protocol developed by Iowa... is making a finding that the Iowa State Implementation Plan (SIP) is substantially inadequate to... ) in Muscatine County, Iowa. The specific SIP deficiencies needing revision are described below. EPA is...

Valsartan Protects Against Contrast-Induced Acute Kidney Injury in Rats by Inhibiting Endoplasmic Reticulum Stress-Induced Apoptosis.

Science.gov (United States)

Sun, Yan; Peng, Ping-An; Ma, Yue; Liu, Xiao-Li; Yu, Yi; Jia, Shuo; Xu, Xiao-Han; Wu, Si-Jing; Zhou, Yu-Jie

2017-01-01

Contrast-induced acute kidney injury (CI-AKI) is a serious complication of the administration of iodinated contrast media (CM) for diagnostic and interventional cardiovascular procedures and is associated with substantial morbidity and mortality. While the preventative measures can mitigate the risk of CI-AKI, there remains a need for novel and effective therapeutic approaches. The pathogenesis of CI-AKI is complex and not completely understood. CM-induced renal tubular cell apoptosis caused by the activation of endoplasmic reticulum (ER) stress is involved in CIAKI. We previously demonstrated that valsartan alleviated CM-induced human renal tubular cell apoptosis by inhibiting ER stress in vitro. However, the nephroprotective effect of valsartan on CI-AKI in vivo has not been investigated. Therefore, the aim of this study was to explore the protective effect of valsartan in a rat model of CI-AKI by measuring the amelioration of renal damage and the changes in ER stressrelated biomarkers. Our results showed that the radiocontrast agent meglumine diatrizoate caused significant renal insufficiency, renin-angiotensin system (RAS) activation, and renal tubular apoptosis by triggering ER stress through activation of glucose-regulated protein 78 (GRP78), activating transcription factor 4 (ATF4), caspase 12, CCAAT/enhancer-binding protein-homologous protein (CHOP) and c-Jun N-terminal protein kinase (JNK) (Pvalsartan significantly alleviated renal dysfunction, pathological injury, and apoptosis along with the inhibition of ER stressrelated biomarkers (PValsartan could protect against meglumine diatrizoate-induced kidney injury in rats by inhibiting the ER stress-induced apoptosis, making it a promising strategy for preventing CI-AKI. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Induced abortion and adolescent mental health.

Science.gov (United States)

Stotland, Nada L

2011-10-01

Induced abortion is widely believed - by the public, healthcare professionals, and policy-makers - to lead to adverse mental health sequelae. This belief is false, as it applies both to adult women and adolescents. However, it has been used to rationalize, and been quoted in, restrictive and intrusive legislation in several states and in proposed federal legislation. It is essential for gynecologists to have accurate information, as clinicians, for their patients, and, as key experts, for policy makers. New articles concluding that there are adverse psychological outcomes from induced abortion continue to be published. The methodological flaws in these articles are so serious as to invalidate those conclusions. Several recent scholarly analyses detail these flaws. Methodologically sound studies and reviews continue to demonstrate that psychosocial problems play a role in unwanted conception and the decision to abort unwanted pregnancies but are not the result of abortion. Clinicians may have to reassure patients making decisions about their pregnancies that abortion does not cause psychiatric illness. They can do so on the basis of recent analyses substantiating that finding. (C) 2011 Lippincott Williams & Wilkins, Inc.

Glycogen synthase kinase-3 inhibition sensitizes human induced pluripotent stem cells to thiol-containing antioxidants induced apoptosis.

Science.gov (United States)

Tu, Chengyi; Xu, Robert; Koleti, Meghana; Zoldan, Janet

2017-08-01

Inhibition of glycogen synthase kinase 3 (GSK3) is an extensively used strategy to activate Wnt pathway for pluripotent stem cell (PSC) differentiation. However, the effects of such inhibition on PSCs, besides upregulating the Wnt pathway, have rarely been investigated despite that GSK3 is broadly involved in other cellular activities such as insulin signaling and cell growth/survival regulation. Here we describe a previously unknown synergistic effect between GSK3 inhibition (e.g., Chir99021 and LY2090314) and various normally non-toxic thiol-containing antioxidants (e.g., N-acetylcysteine, NAC) on the induction of apoptosis in human induced pluripotent stem cells (iPSCs). Neither Chir99021 nor the antioxidants individually induced significant apoptosis, whereas their combined treatment resulted in rapid and extensive apoptosis, with substantial caspase 3 activity observed within 3h and over 90% decrease in cell viability after 24h. We confirmed the generality of this phenomenon with multiple independent iPSCs lines, various thiol-based antioxidants and distinct GSK3 inhibitors. Mechanistically, we demonstrated that rapamycin treatment could substantially reduce cell death, suggesting the critical role of mammalian target of rapamycin (mTOR). Akt dysregulation was also found to partially contribute to cell apoptosis but was not the primary cause. Further, this coordinated proapoptotic effect was not detected in mouse ESCs but was present in another human cells line: a breast cancer cell line (MDA-MB-231). Given the wide use of GSK3 inhibition in biomedical research: from iPSC differentiation to cancer intervention and the treatment of neuronal diseases, researchers can potentially take advantage of or avoid this synergistic effect for improved experimental or clinical outcome. Copyright © 2017. Published by Elsevier B.V.

36 CFR 51.55 - What must a concessioner do after substantial completion of the capital improvement?

Science.gov (United States)

2010-07-01

... together with, if requested by the Director, a written certification from a certified public accountant... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false What must a concessioner do after substantial completion of the capital improvement? 51.55 Section 51.55 Parks, Forests, and Public...

Structural and functional changes in catalase induced by near-UV radiation

International Nuclear Information System (INIS)

Zigman, S.; Schultz, J.B.; McDaniel, T.

1996-01-01

Part one of this study shows that exposure of purified beef liver catalase in buffered solutions to BL lamps that provide a mixture of 99% UVA and 1% UVB (to be labeled UV A ) alters its chemistry and enzymatic activity. Thus, its spectral absorbance lose detail, it aggregated and exhibited a lower isoelectric point and its enzymatic activity was substantially reduced. These photochemically induced changes were increased by irradiation in phosphate buffer or in physiological medium (minimal essential medium) containing riboflavin and tryptophan. Neither α-tocopherol nor deferoxamine were protective against these UV A -induced changes in pure catalase. We further investigated the effect of UV A radiation on the activity of catalase in cultured lens epithelial cells and the protective effects of antioxidants. (Author)

Charge imbalance induced by a temperature gradient in superconducting aluminum

International Nuclear Information System (INIS)

Mamin, H.J.; Clarke, J.; Van Harlingen, D.J.

1984-01-01

The quasiparticle transport current induced in a superconducting aluminum film by a temperature gradient has been measured by means of the spatially decaying charge imbalance generated near the end of the sample where the current is divergent. The magnitude and decay length of the charge imbalance are in good agreement with the predictions of a simple model that takes into account the nonuniformity of the temperature gradient. The inferred value of the thermopower in the superconducting state agrees reasonably well with the value measured in the normal state. Measurements of the decay length of charge imbalance induced by current injection yield a value of the inelastic relaxation time tau/sub E/ of about 2 ns. This value is substantially smaller than that obtained from other measurements for reasons that are not known

Mechanisms of two-color laser-induced field-free molecular orientation.

Science.gov (United States)

Spanner, Michael; Patchkovskii, Serguei; Frumker, Eugene; Corkum, Paul

2012-09-14

Two mechanisms of two-color (ω+2ω) laser-induced field-free molecular orientation, based on the hyperpolarizability and ionization depletion, are explored and compared. The CO molecule is used as a computational example. While the hyperpolarizability mechanism generates small amounts of orientation at intensities below the ionization threshold, ionization depletion quickly becomes the dominant mechanism as soon as ionizing intensities are reached. Only the ionization mechanism leads to substantial orientation (e.g., on the order of ≳0.1). For intensities typical of laser-induced molecular alignment and orientation experiments, the two mechanisms lead to robust, characteristic timings of the field-free orientation wave-packet revivals relative to the alignment revivals and the revival time. The revival timings can be used to detect the active orientation mechanism experimentally.

Evidence for induced radioresistance from survival and other end points: An introduction

International Nuclear Information System (INIS)

Joiner, M.C.

1994-01-01

A substantial body of data published during the past 30 years makes a strong case for the existence of cellular radioprotective mechanisms that can be up-regulated in response to exposure to small doses of ionizing radiation. Either these open-quotes inducedclose quotes mechanisms can protect against a subsequent exposure to radiation that may be substantially larger than the initial open-quotes primingclose quotes or open-quotes conditioningclose quotes dose, or they may influence the shape of the survival response to single doses so that small radiation exposures are more effective per unit dose than larger exposures above a threshold where the induced radioprotection is triggered. Evidence for these effects comes from studies in vitro with protozoa, algae, higher plant cells, insect cells, mammalian and human cells, and studies on animal models in vivo. Work at the molecular level is now confirming that changes in levels of some cytoplasmic and nuclear proteins, and the increased expression of some genes, may occur within a few hours or even minutes of irradiation. This would be sufficiently quick to explain the phenomenon of induced radioresistance although the precise mechanism, whether by repair, cell cycle control or some other process, remains yet undefined. 35 refs

Osteochondritis Dissecans of the Glenoid in a Major League Baseball Prospect: A Case Report.

Science.gov (United States)

Grau, Luis Carlos; Jose, Jean; Sama, Andrew Joseph; Baraga, Michael Gerald

2016-01-01

A 16-year-old Major League Baseball prospect presented with persistent shoulder pain associated with throwing. Magnetic resonance imaging (MRI) demonstrated a large osteochondritis dissecans lesion in the posterosuperior aspect of the glenoid. The patient was restricted from throwing and underwent therapy to improve range of motion and throwing mechanics. Eight months after initiating nonoperative treatment, an MRI arthrogram demonstrated a healed lesion. At follow-up 2 years after treatment, full relief of symptoms had persisted. Osteochondritis dissecans lesions of the glenoid are extremely rare, but have the potential to heal in overhead-throwing athletes. To our knowledge, this is the only case reported in the literature that demonstrates a healed osteochondritis dissecans lesion of the glenoid following nonoperative treatment.

How common is substantial weight gain after pregnancy?

Science.gov (United States)

Sumithran, Priya; Houlihan, Christine; Shub, Alexis; Churilov, Leonid; Pritchard, Natasha; Price, Sarah; Ekinci, Elif; Proietto, Joseph; Permezel, Michael

2017-11-20

Although population-based studies indicate that on average, women gain 1-2kg between pregnancies, women with obesity often attribute its development to childbearing. There is little contemporary data available regarding how commonly this occurs, particularly in women of different body mass index (BMI) categories. The aim of this study was to examine inter-pregnancy weight changes among women at a tertiary obstetric hospital in Melbourne, Australia. This was a retrospective review of data from the Birthing Outcomes System electronic record of 19,617 women aged 20 years or older, who delivered at least two consecutive singleton infants at ≥37 weeks' gestation at Mercy Hospital for Women between December 1994 and December 2015. A logistic regression model was used to assess the relationship between gain of ≥4kg/m 2 between pregnancies and maternal BMI category in the first pregnancy, adjusting for covariates of maternal age, inter-pregnancy interval, and socioeconomic status. Gain of ≥4kg/m 2 between the first two pregnancies occurred in 7.5% of normal weight women, 10.5% of overweight women, and 13.4% of women with obesity. One in five women who were normal weight in their first pregnancy increased to overweight or obese BMI categories in their second pregnancy. Substantial weight gain in relation to pregnancy affects a considerable proportion of women. Since inter-pregnancy weight gain is associated with several complications in the next pregnancy and longer term, avoiding excessive weight gain during and between pregnancies may prevent adverse health consequences in mothers and offspring. Copyright © 2017 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

Holi colours contain PM10 and can induce pro-inflammatory responses.

Science.gov (United States)

Bossmann, Katrin; Bach, Sabine; Höflich, Conny; Valtanen, Kerttu; Heinze, Rita; Neumann, Anett; Straff, Wolfgang; Süring, Katrin

2016-01-01

At Holi festivals, originally celebrated in India but more recently all over the world, people throw coloured powder (Holi powder, Holi colour, Gulal powder) at each other. Adverse health effects, i.e. skin and ocular irritations as well as respiratory problems may be the consequences. The aim of this study was to uncover some of the underlying mechanisms. We analysed four different Holi colours regarding particle size using an Electric field cell counting system. In addition, we incubated native human cells with different Holi colours and determined their potential to induce a pro-inflammatory response by quantifying the resulting cytokine production by means of ELISA (Enzyme Linked Immunosorbent Assay) and the resulting leukocyte oxidative burst by flow cytometric analysis. Moreover, we performed the XTT (2,3-Bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide) and Propidium iodide cytotoxicity tests and we measured the endotoxin content of the Holi colour samples by means of the Limulus Amebocyte Lysate test (LAL test). We show here that all tested Holi colours consist to more than 40 % of particles with an aerodynamic diameter smaller than 10 μm, so called PM10 particles (PM, particulate matter). Two of the analysed Holi powders contained even more than 75 % of PM10 particles. Furthermore we demonstrate in cell culture experiments that Holi colours can induce the production of the pro-inflammatory cytokines TNF-α (Tumor necrosis factor-α), IL-6 (Interleukine-6) and IL-1β (Interleukine-1β). Three out of the four analysed colours induced a significantly higher cytokine response in human PBMCs (Peripheral Blood Mononuclear Cells) and whole blood than corn starch, which is often used as carrier substance for Holi colours. Moreover we show that corn starch and two Holi colours contain endotoxin and that certain Holi colours display concentration dependent cytotoxic effects in higher concentration. Furthermore we reveal that in principle Holi

A Paleocene penguin from New Zealand substantiates multiple origins of gigantism in fossil Sphenisciformes

OpenAIRE

Mayr, Gerald; Scofield, R. Paul; De Pietri, Vanesa L.; Tennyson, Alan J. D.

2017-01-01

One of the notable features of penguin evolution is the occurrence of very large species in the early Cenozoic, whose body size greatly exceeded that of the largest extant penguins. Here we describe a new giant species from the late Paleocene of New Zealand that documents the very early evolution of large body size in penguins. Kumimanu biceae, n. gen. et sp. is larger than all other fossil penguins that have substantial skeletal portions preserved. Several plesiomorphic features place the ne...

Substantially Enhancing Quantum Coherence of Electrons in Graphene via Electron-Plasmon Coupling.

Science.gov (United States)

Cheng, Guanghui; Qin, Wei; Lin, Meng-Hsien; Wei, Laiming; Fan, Xiaodong; Zhang, Huayang; Gwo, Shangjr; Zeng, Changgan; Hou, J G; Zhang, Zhenyu

2017-10-13

The interplays between different quasiparticles in solids lay the foundation for a wide spectrum of intriguing quantum effects, yet how the collective plasmon excitations affect the quantum transport of electrons remains largely unexplored. Here we provide the first demonstration that when the electron-plasmon coupling is introduced, the quantum coherence of electrons in graphene is substantially enhanced with the quantum coherence length almost tripled. We further develop a microscopic model to interpret the striking observations, emphasizing the vital role of the graphene plasmons in suppressing electron-electron dephasing. The novel and transformative concept of plasmon-enhanced quantum coherence sheds new insight into interquasiparticle interactions, and further extends a new dimension to exploit nontrivial quantum phenomena and devices in solid systems.

Dammarane Sapogenins Ameliorates Neurocognitive Functional Impairment Induced by Simulated Long-Duration Spaceflight

Directory of Open Access Journals (Sweden)

Xiaorui Wu

2017-05-01

Full Text Available Increasing evidence indicates the occurrence of cognitive impairment in astronauts under spaceflight compound conditions, but the underlying mechanisms and countermeasures need to be explored. In this study, we found that learning and memory abilities were significantly reduced in rats under a simulated long-duration spaceflight environment (SLSE, which includes microgravity, isolation confinement, noises, and altered circadian rhythms. Dammarane sapogenins (DS, alkaline hydrolyzed products of ginsenosides, can enhance cognition function by regulating brain neurotransmitter levels and inhibiting SLSE-induced neuronal injury. Bioinformatics combined with experimental verification identified that the PI3K-Akt-mTOR pathway was inhibited and the MAPK pathway was activated during SLSE-induced cognition dysfunction, whereas DS substantially ameliorated the changes in brain. These findings defined the characteristics of SLSE-induced cognitive decline and the mechanisms by which DS improves it. The results provide an effective candidate for improving cognitive function in spaceflight missions.

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to a combination of lycopene, proanthocyanidins, vitamin C, vitamin E, selenium and beta-carotene and contribution to normal collagen formation (ID 1669) and protection, of the skin from UV-induced damage (ID 1669) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

DEFF Research Database (Denmark)

Tetens, Inge

claims in relation to a combination of lycopene, proanthocyanidins, vitamin C, vitamin E, selenium and beta-carotene and contribution to normal collagen formation and protection of the skin from UV-induced damage. The scientific substantiation is based on the information provided by the Member States...... in the consolidated list of Article 13 health claims and references that EFSA has received from Member States or directly from stakeholders. The food constituent that is the subject of the health claim is a combination of lycopene, proanthocyanidins, vitamin C, vitamin E, selenium, and beta-carotene. The Panel...... considers that the combination of lycopene, proanthocyanidins, vitamin C, vitamin E, selenium, and beta-carotene is sufficiently characterised....

Lethal and pre-lethal effects of a fungal biopesticide contribute to substantial and rapid control of malaria vectors.

Directory of Open Access Journals (Sweden)

Simon Blanford

Full Text Available Rapidly emerging insecticide resistance is creating an urgent need for new active ingredients to control the adult mosquitoes that vector malaria. Biopesticides based on the spores of entomopathogenic fungi have shown considerable promise by causing very substantial mortality within 7-14 days of exposure. This mortality will generate excellent malaria control if there is a high likelihood that mosquitoes contact fungi early in their adult lives. However, where contact rates are lower, as might result from poor pesticide coverage, some mosquitoes will contact fungi one or more feeding cycles after they acquire malaria, and so risk transmitting malaria before the fungus kills them. Critics have argued that 'slow acting' fungal biopesticides are, therefore, incapable of delivering malaria control in real-world contexts. Here, utilizing standard WHO laboratory protocols, we demonstrate effective action of a biopesticide much faster than previously reported. Specifically, we show that transient exposure to clay tiles sprayed with a candidate biopesticide comprising spores of a natural isolate of Beauveria bassiana, could reduce malaria transmission potential to zero within a feeding cycle. The effect resulted from a combination of high mortality and rapid fungal-induced reduction in feeding and flight capacity. Additionally, multiple insecticide-resistant lines from three key African malaria vector species were completely susceptible to fungus. Thus, fungal biopesticides can block transmission on a par with chemical insecticides, and can achieve this where chemical insecticides have little impact. These results support broadening the current vector control paradigm beyond fast-acting chemical toxins.

Substantiating the Target Level of Economic Security of Transport Enterprises and the Instrumentarium for Its Provision

Directory of Open Access Journals (Sweden)

Lebedko Sergiy A.

2017-10-01

Full Text Available The article is aimed at substantiating the methodology for assessing the economic security of transport enterprises, determining the target level and the instrumentarium for its provision. The proposed methodical approach to the assessment of the level of economic security of transport enterprises includes the determination of the level of counteracting threats and is based on the principles of integral estimation. The formed integrated indicator includes both indicators of counteracting the internal (human, managerial and technological, force majeure, financial and external threats (market, stakeholder, power-based, natural, infrastructural. Each measure of counteracting threats is determined by results of assessment of dynamics of the three indicators. A practical testing of the proposed approach is carried out in the case of transport enterprises. Based on the established equation of the regression relationship between the level of economic security and the financial strength, a target level of economic security of transport enterprises has been substantiated. The instrumentarium to provide a targeted level of economic security according to the threat types, including preventive and reactive measures, has been developed.

Universal Effectiveness of Inducing Magnetic Moments in Graphene by Amino-Type sp3-Defects

Directory of Open Access Journals (Sweden)

Tao Tang

2018-04-01

Full Text Available Inducing magnetic moments in graphene is very important for its potential application in spintronics. Introducing sp3-defects on the graphene basal plane is deemed as the most promising approach to produce magnetic graphene. However, its universal validity has not been very well verified experimentally. By functionalization of approximately pure amino groups on graphene basal plane, a spin-generalization efficiency of ~1 μB/100 NH2 was obtained for the first time, thus providing substantial evidence for the validity of inducing magnetic moments by sp3-defects. As well, amino groups provide another potential sp3-type candidate to prepare magnetic graphene.

Hydrogen-Induced Plastic Deformation in ZnO

Science.gov (United States)

Lukáč, F.; Čížek, J.; Vlček, M.; Procházka, I.; Anwand, W.; Brauer, G.; Traeger, F.; Rogalla, D.; Becker, H.-W.

In the present work hydrothermally grown ZnO single crystals covered with Pd over-layer were electrochemically loaded with hydrogen and the influence of hydrogen on ZnO micro structure was investigated by positron annihilation spectroscopy (PAS). Nuclear reaction analysis (NRA) was employed for determination of depth profile of hydrogen concentration in the sample. NRA measurements confirmed that a substantial amount of hydrogen was introduced into ZnO by electrochemical charging. The bulk hydrogen concentration in ZnO determined by NRA agrees well with the concentration estimated from the transported charge using the Faraday's law. Moreover, a subsurface region with enhanced hydrogen concentration was found in the loaded crystals. Slow positron implantation spectroscopy (SPIS) investigations of hydrogen-loaded crystal revealed enhanced concentration of defects in the subsurface region. This testifies hydrogen-induced plastic deformation of the loaded crystal. Absorbed hydrogen causes a significant lattice expansion. At low hydrogen concentrations this expansion is accommodated by elastic straining, but at higher concentrations hydrogen-induced stress exceeds the yield stress in ZnO and plastic deformation of the loaded crystal takes place. Enhanced hydrogen concentration detected in the subsurface region by NRA is, therefore, due to excess hydrogen trapped at open volume defects introduced by plastic deformation. Moreover, it was found that hydrogen-induced plastic deformation in the subsurface layer leads to typical surface modification: formation of hexagonal shape pyramids on the surface due to hydrogen-induced slip in the [0001] direction.

Wnt5a signaling is a substantial constituent in bone morphogenetic protein-2-mediated osteoblastogenesis

International Nuclear Information System (INIS)

Nemoto, Eiji; Ebe, Yukari; Kanaya, Sousuke; Tsuchiya, Masahiro; Nakamura, Takashi; Tamura, Masato; Shimauchi, Hidetoshi

2012-01-01

Highlights: ► Wnt5a is identified in osteoblasts in tibial growth plate and bone marrow. ► Osteoblastic differentiation is associated with increased expression of Wnt5a/Ror2. ► Wnt5a/Ror2 signaling is important for BMP-2-mediated osteoblastic differentiation. ► Wnt5a/Ror2 operates independently of BMP-Smad pathway. -- Abstract: Wnts are secreted glycoproteins that mediate developmental and post-developmental physiology by regulating cellular processes including proliferation, differentiation, and apoptosis through β-catenin-dependent canonical and β-catenin-independent noncanonical pathway. It has been reported that Wnt5a activates noncanonical Wnt signaling through receptor tyrosine kinase-like orphan receptor 2 (Ror2). Although it appears that Wnt5a/Ror2 signaling supports normal bone physiology, the biological significance of noncanonical Wnts in osteogenesis is essentially unknown. In this study, we identified expression of Wnt5a in osteoblasts in the ossification zone of the tibial growth plate as well as bone marrow of the rat tibia as assessed by immunohistochemistry. In addition, we show that osteoblastic differentiation mediated by BMP-2 is associated with increased expression of Wnt5a and Ror2 using cultured pre-osteoblasts, MC3T3-E1 cells. Silencing gene expression of Wnt5a and Ror2 in MC3T3-E1 cells results in suppression of BMP-2-mediated osteoblastic differentiation, suggesting that Wnt5a and Ror2 signaling are of substantial importance for BMP-2-mediated osteoblastic differentiation. BMP-2 stimulation induced phosphorylation of Smad1/5/8 in a similar fashion in both siWnt5a-treated cells and control cells, suggesting that Wnt5a was dispensable for the phosphorylation of Smads by BMP-2. Taken together, our results suggest that Wnt5a/Ror2 signaling appears to be involved in BMP-2-mediated osteoblast differentiation in a Smad independent pathway.

Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats.

Science.gov (United States)

Geurts, Aron M; Mattson, David L; Liu, Pengyuan; Cabacungan, Erwin; Skelton, Meredith M; Kurth, Theresa M; Yang, Chun; Endres, Bradley T; Klotz, Jason; Liang, Mingyu; Cowley, Allen W

2015-02-01

Environmental exposure of parents or early in life may affect disease development in adults. We found that hypertension and renal injury induced by a high-salt diet were substantially attenuated in Dahl SS/JrHsdMcwiCrl (SS/Crl) rats that had been maintained for many generations on the grain-based 5L2F diet compared with SS/JrHsdMcwi rats (SS/Mcw) maintained on the casein-based AIN-76A diet (mean arterial pressure, 116±9 versus 154±25 mm Hg; urinary albumin excretion, 23±12 versus 170±80 mg/d). RNAseq analysis of the renal outer medulla identified 129 and 82 genes responding to a high-salt diet uniquely in SS/Mcw and SS/Crl rats, respectively, along with minor genetic differences between the SS substrains. The 129 genes responding to salt in the SS/Mcw strain included numerous genes with homologs associated with hypertension, cardiovascular disease, or renal disease in human. To narrow the critical window of exposure, we performed embryo-transfer experiments in which single-cell embryos from 1 colony (SS/Mcw or SS/Crl) were transferred to surrogate mothers from the other colony, with parents and surrogate mothers maintained on their respective original diet. All offspring were fed the AIN-76A diet after weaning. Salt-induced hypertension and renal injury were substantially exacerbated in rats developed from SS/Crl embryos transferred to SS/Mcw surrogate mothers. Conversely, salt-induced hypertension and renal injury were significantly attenuated in rats developed from SS/Mcw embryos transferred to SS/Crl surrogate mothers. Together, the data suggest that maternal diet during the gestational-lactational period has substantial effects on the development of salt-induced hypertension and renal injury in adult SS rats. © 2014 American Heart Association, Inc.

Substantial proportion of global streamflow less than three months old

Science.gov (United States)

Jasechko, Scott; Kirchner, James W.; Welker, Jeffrey M.; McDonnell, Jeffrey J.

2016-02-01

Biogeochemical cycles, contaminant transport and chemical weathering are regulated by the speed at which precipitation travels through landscapes and reaches streams. Streamflow is a mixture of young and old precipitation, but the global proportions of these young and old components are not known. Here we analyse seasonal cycles of oxygen isotope ratios in rain, snow and streamflow compiled from 254 watersheds around the world, and calculate the fraction of streamflow that is derived from precipitation that fell within the past two or three months. This young streamflow accounts for about a third of global river discharge, and comprises at least 5% of discharge in about 90% of the catchments we investigated. We conclude that, although typical catchments have mean transit times of years or even decades, they nonetheless can rapidly transmit substantial fractions of soluble contaminant inputs to streams. Young streamflow is less prevalent in steeper landscapes, which suggests they are characterized by deeper vertical infiltration. Because young streamflow is derived from less than 0.1% of global groundwater storage, we conclude that this thin veneer of aquifer storage will have a disproportionate influence on stream water quality.

Fusion--fission hybrid concepts for laser-induced fusion

International Nuclear Information System (INIS)

Maniscalco, J.

1976-01-01

Fusion-fission hybrid concepts are viewed as subcritical fission reactors driven and controlled by high-energy neutrons from a laser-induced fusion reactor. Blanket designs encompassing a substantial portion of the spectrum of different fission reactor technologies are analyzed and compared by calculating their fissile-breeding and fusion-energy-multiplying characteristics. With a large number of different fission technologies to choose from, it is essential to identify more promising hybrid concepts that can then be subjected to in-depth studies that treat the engineering safety, and economic requirements as well as the neutronic aspects. In the course of neutronically analyzing and comparing several fission blanket concepts, this work has demonstrated that fusion-fission hybrids can be designed to meet a broad spectrum of fissile-breeding and fusion-energy-multiplying requirements. The neutronic results should prove to be extremely useful in formulating the technical scope of future studies concerned with evaluating the technical and economic feasibility of hybrid concepts for laser-induced fusion

Polyamine-Induced Rapid Root Abscission in Azolla pinnata.

Science.gov (United States)

Gurung, Sushma; Cohen, Michael F; Fukuto, Jon; Yamasaki, Hideo

2012-01-01

Floating ferns of the genus Azolla detach their roots under stress conditions, a unique adaptive response termed rapid root abscission. We found that Azolla pinnata plants exhibited dose-dependent rapid root abscission in response to the polyamines spermidine and spermine after a substantial time lag (>20 min). The duration of the time lag decreased in response to high pH and high temperature whereas high light intensity increased the time lag and markedly lowered the rate of abscission. The oxidation products of polyamines, 1,3-diaminopropane, β-alanine and hydrogen peroxide all failed to initiate root abscission, and hydroxyethyl hydrazine, an inhibitor of polyamine oxidase, did not inhibit spermine-induced root abscission. Exposure of A. pinnata to the polyamines did not result in detectable release of NO and did not affect nitrite-dependent NO production. The finding of polyamine-induced rapid root abscission provides a facile assay for further study of the mode of action of polyamines in plant stress responses.

Electronic excitation induced modifications of optical and morphological properties of PCBM thin films

Energy Technology Data Exchange (ETDEWEB)

Sharma, T. [Department of Physics and Materials Research Centre, Malaviya National Institute of Technology, Jaipur 302017 (India); Singhal, R., E-mail: rsinghal.phy@mnit.ac.in [Department of Physics and Materials Research Centre, Malaviya National Institute of Technology, Jaipur 302017 (India); Vishnoi, R. [Department of Physics and Materials Research Centre, Malaviya National Institute of Technology, Jaipur 302017 (India); Department of Physics, Vardhman (P.G.) College, Bijnor 246701, U.P. (India); Sharma, P. [Department of Physics and Materials Research Centre, Malaviya National Institute of Technology, Jaipur 302017 (India); Patra, A.; Chand, S. [National Physical Laboratory, Dr. K. S. Krishnan Marg, New Delhi 110012 (India); Lakshmi, G.B.V.S. [Inter University Accelerator Centre, Post Box No. 10502, New Delhi 110067 (India); Biswas, S.K. [Department of Metallurgical and Materials Engineering, Malaviya National Institute of Technology, Jaipur 302017 (India)

2016-07-15

Highlights: • Spin casted PCBM thin films are irradiated by 90 MeV Ni{sup 7+} ion beam. • The decrease in band gap was found after irradiation. • There is a decomposition of molecular bond due to ion irradiation. • Roughness is also found to be dependent on incident ion fluence. - Abstract: Phenyl C{sub 61} butyric acid methyl ester (PCBM) is a fullerene derivative and most commonly used in organic photovoltaic devices both as electron acceptor and transporting material due to high electron mobility. PCBM is easy to spin caste on some substrate as it is soluble in chlorobenzene. In this study, the spin coated thin films of PCBM (on two different substrate, glass and double sided silicon) were irradiated using 90 MeV Ni{sup 7+} swift heavy ion beam at low fluences ranging from 1 × 10{sup 9} to 1 × 10{sup 11} ions/cm{sup 2} to study the effect of ion beam irradiation. The pristine and irradiated PCBM thin films were characterized by UV–visible absorption spectroscopy and fourier transform infrared spectroscopy (FTIR) to investigate the optical properties before and after irradiation. These thin films were further analyzed using atomic force microscopy (AFM) to investigate the morphological modifications which are induced by energetic ions. The variation in optical band gap after irradiation was measured using Tauc’s relation from UV–visible absorption spectra. A considerable change was observed with increasing fluence in optical band gap of irradiated thin films of PCBM with respect to the pristine film. The decrease in FTIR band intensity of C{sub 60} cage reveals the polymerization reaction due to high energy ion impact. The roughness is also found to be dependent on incident fluences. This study throws light for the application of PCBM in organic solar cells in form of ion irradiation induced nanowires of PCBM for efficient charge carrier transportation in active layer.

Substantial secondary organic aerosol formation in a coniferous forest: observations of both day- and nighttime chemistry

OpenAIRE

A. K. Y. Lee; J. P. D. Abbatt; W. R. Leaitch; S.-M. Li; S. J. Sjostedt; S. J. Sjostedt; J. J. B. Wentzell; J. Liggio; A. M. Macdonald

2016-01-01

Substantial biogenic secondary organic aerosol (BSOA) formation was investigated in a coniferous forest mountain region at Whistler, British Columbia. A largely biogenic aerosol growth episode was observed, providing a unique opportunity to investigate BSOA formation chemistry in a forested environment with limited influence from anthropogenic emissions. Positive matrix factorization of aerosol mass spectrometry (AMS) measurement identifie...

A contemplation in negation and emphasizes of outstanding philosophers of Tehran philosophy school in immortality of subject in substantial movement.

Directory of Open Access Journals (Sweden)

mohamad khosravi farsani

2015-03-01

Full Text Available Agha Ali and Jelveh ,two of outstanding of Tehran philosophy school, have reconsidered Sandra's opinions in two opposite sides. Agha Ali is the claimant of negation and ambiguity in most of Sandra's opinions while emphasizing on transcendent theosophy foundations ,and he tries to make these ambiguities clear .However , Jelveh follows Avicenna's way and has the idea of criticizing Sandra .This article has chosen the problem Of immortality of subject in substantial movement between all debates of these two philosophers of the same age.in this essay we are going to survey Agha Ali's claims in his new explantation in one hand ,and survey and criticize the new explanation of Jelveh in negation Of substantial movement .One of the consequences of surveying and criticizing these two philosophers is that we recognize Agha Ali has succeeded in making Sadra's opinions clear by presenting a new explanation of substantial movement subject. However ,Jelveh has merged Sadra's opinions with Avicenna's instead of debilitating Sadra's opinions and stabilizing Avicenna's opinions.

Method and device for marine disposal of radioactive wastes

International Nuclear Information System (INIS)

Tsuda, Shigeo.

1978-01-01

Purpose: To provide the subject method and device wherein a unit thrown away can body formed by firmly tying a several drum vessels is thrown away in seawater thereby carrying out a throw-away operation rapidly, safely and highly efficiently. Method: In the hatch is stacked in multistage a unit throw-away can body formed by firmly tying four drums. A self-travelling suspended bedplate with a thrown away rail device runs on rails, and is fixed to a necessary position. An accomodation and throwing away operation control chamber applied with radiation protection is attached to this self-travelling suspended bedplate to perform surveillance of the interior of the chamber, and accommodation and throwing away operation is carried out by a picture image sent from a television camera and safe and accurate operations. (Nakamura, S.)

Predicting risk of substantial weight gain in German adults-a multi-center cohort approach.

Science.gov (United States)

Bachlechner, Ursula; Boeing, Heiner; Haftenberger, Marjolein; Schienkiewitz, Anja; Scheidt-Nave, Christa; Vogt, Susanne; Thorand, Barbara; Peters, Annette; Schipf, Sabine; Ittermann, Till; Völzke, Henry; Nöthlings, Ute; Neamat-Allah, Jasmine; Greiser, Karin-Halina; Kaaks, Rudolf; Steffen, Annika

2017-08-01

A risk-targeted prevention strategy may efficiently utilize limited resources available for prevention of overweight and obesity. Likewise, more efficient intervention trials could be designed if selection of subjects was based on risk. The aim of the study was to develop a risk score predicting substantial weight gain among German adults. We developed the risk score using information on 15 socio-demographic, dietary and lifestyle factors from 32 204 participants of five population-based German cohort studies. Substantial weight gain was defined as gaining ≥10% of weight between baseline and follow-up (>6 years apart). The cases were censored according to the theoretical point in time when the threshold of 10% baseline-based weight gain was crossed assuming linearity of weight gain. Beta coefficients derived from proportional hazards regression were used as weights to compute the risk score as a linear combination of the predictors. Cross-validation was used to evaluate the score's discriminatory accuracy. The cross-validated c index (95% CI) was 0.71 (0.67-0.75). A cutoff value of ≥475 score points yielded a sensitivity of 71% and a specificity of 63%. The corresponding positive and negative predictive values were 10.4% and 97.6%, respectively. The proposed risk score may support healthcare providers in decision making and referral and facilitate an efficient selection of subjects into intervention trials. © The Author 2016. Published by Oxford University Press on behalf of the European Public Health Association.

Predicting risk of substantial weight gain in German adults—a multi-center cohort approach

Science.gov (United States)

Bachlechner, Ursula; Boeing, Heiner; Haftenberger, Marjolein; Schienkiewitz, Anja; Scheidt-Nave, Christa; Vogt, Susanne; Thorand, Barbara; Peters, Annette; Schipf, Sabine; Ittermann, Till; Völzke, Henry; Nöthlings, Ute; Neamat-Allah, Jasmine; Greiser, Karin-Halina; Kaaks, Rudolf

2017-01-01

Abstract Background A risk-targeted prevention strategy may efficiently utilize limited resources available for prevention of overweight and obesity. Likewise, more efficient intervention trials could be designed if selection of subjects was based on risk. The aim of the study was to develop a risk score predicting substantial weight gain among German adults. Methods We developed the risk score using information on 15 socio-demographic, dietary and lifestyle factors from 32 204 participants of five population-based German cohort studies. Substantial weight gain was defined as gaining ≥10% of weight between baseline and follow-up (>6 years apart). The cases were censored according to the theoretical point in time when the threshold of 10% baseline-based weight gain was crossed assuming linearity of weight gain. Beta coefficients derived from proportional hazards regression were used as weights to compute the risk score as a linear combination of the predictors. Cross-validation was used to evaluate the score’s discriminatory accuracy. Results The cross-validated c index (95% CI) was 0.71 (0.67–0.75). A cutoff value of ≥475 score points yielded a sensitivity of 71% and a specificity of 63%. The corresponding positive and negative predictive values were 10.4% and 97.6%, respectively. Conclusions The proposed risk score may support healthcare providers in decision making and referral and facilitate an efficient selection of subjects into intervention trials. PMID:28013243

Recommendations for successful substantiation of new health claims in the European Union

DEFF Research Database (Denmark)

Pravst, Igor; Kušar, Anita; Žmitek, Katja

2018-01-01

Background While functional foods offer promise for public health and innovation in the food industry, the efficiency of such foods should be assured to protect consumers from misleading claims. Globally, many countries regulate the communication of the health effects of such foods to final...... consumers. Scope and approach In the European Union (EU), the use of health claims was harmonized in 2006. All claims need to be scientifically assessed by the European Food Safety Authority (EFSA) and pre-approved. Implementing the regulation has involved a steep learning curve for stakeholders, resulting...... recommendations should be seen as a starting point for researchers in the area of nutrition and food technology, and for those dealing with functional foods, including the food industry. Keywords Functional foods; Health claims; Food labelling; Substantiation; Regulation; European Union...

Experimental substantiation of methodic of 11-13 years old boxers’ coordination development

Directory of Open Access Journals (Sweden)

Yong Qiang Liu

2015-06-01

Full Text Available Purpose: experimental substantiation of methodic of junior boxers’ coordination training. Material: in the research 18 boxers of 11-13 year old age participated. In total, during 4 months 42 trainings were conducted. Total time of coordination load’s fulfillment at each training was 15-45 minutes. Results: dynamic of results in control tests was statistically confident in the tested parameters of movements. It proves effectiveness of usage the tasks with complex-coordination orientation, accented on impact on sensor-informational and motor systems of movements in junior boxers’ trainings. Conclusions: coordination training in boxing at initial stage shall include specialized varied means and methods, which would facilitate formation of motor condition and skills’ basis. Motor condition and skills are a reserve for further rising of coordination abilities’ level of junior sportsmen.

Molecular targets in radiation-induced blood-brain barrier disruption

International Nuclear Information System (INIS)

Nordal, Robert A.; Wong, C. Shun

2005-01-01

Disruption of the blood-brain barrier (BBB) is a key feature of radiation injury to the central nervous system. Studies suggest that endothelial cell apoptosis, gene expression changes, and alteration of the microenvironment are important in initiation and progression of injury. Although substantial effort has been directed at understanding the impact of radiation on endothelial cells and oligodendrocytes, growing evidence suggests that other cell types, including astrocytes, are important in responses that include induced gene expression and microenvironmental changes. Endothelial apoptosis is important in early BBB disruption. Hypoxia and oxidative stress in the later period that precedes tissue damage might lead to astrocytic responses that impact cell survival and cell interactions. Cell death, gene expression changes, and a toxic microenvironment can be viewed as interacting elements in a model of radiation-induced disruption of the BBB. These processes implicate particular genes and proteins as targets in potential strategies for neuroprotection

Corn silk induces nitric oxide synthase in murine macrophages.

Science.gov (United States)

Kim, Kyung A; Choi, Sang Kyu; Choi, Hye Seon

2004-12-31

Corn silk has been purified as an anticoagulant previously and the active component is a polysaccharide with a molecular mass of 135 kDa. It activates murine macrophages to induce nitric oxide synthase (NOS) and generate substantial amounts of NO in time and dose-dependent manners. It was detectable first at 15 h after stimulation by corn silk, peaked at 24 h, and undetectable by 48 h. Induction of NOS is inhibited by pyrolidine dithiocarbamate (PDTC) and genistein, an inhibitor of nuclear factor kappa B (NF-kappaB) and tyrosine kinase, respectively, indicating that iNOS stimulated by corn silk is associated with tyrosine kinase and NF-kappaB signaling pathways. IkappaB-alpha degradation was detectible at 10 min, and the level was restored at 120 min after treatment of corn silk. Corn silk induced nuclear translocation of NF-kappaB by phosphorylation and degradation of IkappaB-alpha.

Transforming growth factor-β synthesized by stromal cells and cancer cells participates in bone resorption induced by oral squamous cell carcinoma

International Nuclear Information System (INIS)

Nakamura, Ryosuke; Kayamori, Kou; Oue, Erika; Sakamoto, Kei; Harada, Kiyoshi; Yamaguchi, Akira

2015-01-01

Transforming growth factor beta (TGF-β) plays a significant role in the regulation of the tumor microenvironment. To explore the role of TGF-β in oral cancer-induced bone destruction, we investigated the immunohistochemical localization of TGF-β and phosphorylated Smad2 (p-Smad2) in 12 surgical specimens of oral squamous cell carcinoma (OSCC). These studies revealed TGF-β and p-Smad2 expression in cancer cells in all tested cases. Several fibroblasts located between cancer nests and resorbing bone expressed TGF-β in 10 out of 12 cases and p-Smad2 in 11 out of 12 cases. Some osteoclasts also exhibited p ∼ Smad2 expression. The OSCC cell line, HSC3, and the bone marrow-derived fibroblastic cell line, ST2, synthesized substantial levels of TGF-β. Culture media derived from HSC3 cells could stimulate Tgf-β1 mRNA expression in ST2 cells. Recombinant TGF-β1 could stimulate osteoclast formation induced by receptor activator of nuclear factor kappa-B ligand (RANKL) in RAW264 cells. TGF-β1 could upregulate the expression of p-Smad2 in RAW264 cells, and this action was suppressed by the addition of a neutralizing antibody against TGF-β or by SB431542. Transplantation of HSC3 cells onto the calvarial region of athymic mice caused bone destruction, associated with the expression of TGF-β and p-Smad2 in both cancer cells and stromal cells. The bone destruction was substantially inhibited by the administration of SB431542. The present study demonstrated that TGF-β synthesized by both cancer cells and stromal cells participates in the OSCC-induced bone destruction. - Highlights: • Cancer cell, fibroblastic cells, and osteoclasts at bone resorbing area by oral cancer exhibited TGF-β and p-Smad2. • TGF-β1 stimulated osteoclastogenesis induced by RAKL in RAW264 cell. • Xenograft model of oral cancer-induced bone resorption was substantially inhibited by SB431542. • TGF-β synthesized by both cancer cells and stromal cells participates in the OSCC-induced

Transforming growth factor-β synthesized by stromal cells and cancer cells participates in bone resorption induced by oral squamous cell carcinoma

Energy Technology Data Exchange (ETDEWEB)

Nakamura, Ryosuke [Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Japan); Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Japan); Kayamori, Kou [Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Japan); Oue, Erika [Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Japan); Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Japan); Sakamoto, Kei [Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Japan); Harada, Kiyoshi [Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Japan); Yamaguchi, Akira, E-mail: akira.mpa@tmd.ac.jp [Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (Japan)

2015-03-20

Transforming growth factor beta (TGF-β) plays a significant role in the regulation of the tumor microenvironment. To explore the role of TGF-β in oral cancer-induced bone destruction, we investigated the immunohistochemical localization of TGF-β and phosphorylated Smad2 (p-Smad2) in 12 surgical specimens of oral squamous cell carcinoma (OSCC). These studies revealed TGF-β and p-Smad2 expression in cancer cells in all tested cases. Several fibroblasts located between cancer nests and resorbing bone expressed TGF-β in 10 out of 12 cases and p-Smad2 in 11 out of 12 cases. Some osteoclasts also exhibited p ∼ Smad2 expression. The OSCC cell line, HSC3, and the bone marrow-derived fibroblastic cell line, ST2, synthesized substantial levels of TGF-β. Culture media derived from HSC3 cells could stimulate Tgf-β1 mRNA expression in ST2 cells. Recombinant TGF-β1 could stimulate osteoclast formation induced by receptor activator of nuclear factor kappa-B ligand (RANKL) in RAW264 cells. TGF-β1 could upregulate the expression of p-Smad2 in RAW264 cells, and this action was suppressed by the addition of a neutralizing antibody against TGF-β or by SB431542. Transplantation of HSC3 cells onto the calvarial region of athymic mice caused bone destruction, associated with the expression of TGF-β and p-Smad2 in both cancer cells and stromal cells. The bone destruction was substantially inhibited by the administration of SB431542. The present study demonstrated that TGF-β synthesized by both cancer cells and stromal cells participates in the OSCC-induced bone destruction. - Highlights: • Cancer cell, fibroblastic cells, and osteoclasts at bone resorbing area by oral cancer exhibited TGF-β and p-Smad2. • TGF-β1 stimulated osteoclastogenesis induced by RAKL in RAW264 cell. • Xenograft model of oral cancer-induced bone resorption was substantially inhibited by SB431542. • TGF-β synthesized by both cancer cells and stromal cells participates in the OSCC-induced

Shock-induced nanobubble collapse and its applications

Science.gov (United States)

Vedadi, Mohammad Hossein

The shock-induced collapse of nanobubbles in water is investigated using molecular dynamics simulations based on a reactive force field. Monitoring the collapse of a cavitation nanobubble, we observe a focused nanojet at the onset of bubble shrinkage and a water hammer shock wave upon bubble collapse. The nanojet length scales linearly with the nanobubble radius, as observed in experiments on micron-to-millimeter size bubbles. The shock induces dramatic structural changes, including an ice-VII-like structural motif at a particle velocity of approximately 1 km/s. The incipient ice VII formation and the calculated Hugoniot curve are in good agreement with experimental results. Moreover, a substantial number of positive and negative ions appear when the nanojet hits the distal side of the nanobubble and the water hammer shock forms. Furthermore, two promising applications of shock-induced nanobubble collapse have been explored. Our simulations of poration in lipid bilayers due to shock-induced collapse of nanobubbles reveal penetration of nanojets into lipid bilayers. The nanojet impact generates shear flow of water on bilayer leaflets and pressure gradients across them, which transiently enhance the bilayer permeability by creating nanopores through which water molecules translocate across the bilayer. The effects of nanobubble size and temperature on the porosity of lipid bilayers are examined. Finally, the shock-induced collapse of CO2-filled nanobubbles in water is investigated. The energetic nanojet and high-pressure water hammer shock formed during and after collapse of the nanobubble trigger mechano-chemical H2O-CO2 reactions, some of which lead to splitting of water molecules. The dominant pathways through which splitting of water molecules occur are identified.

Reactor antineutrino spectra and their application to antineutrino-induced reactions II

International Nuclear Information System (INIS)

Vogel, P.; Schenter, G.K.; Mann, F.M.; Schenter, R.E.

1980-12-01

The antineutrino and electron spectra associated with various nuclear fuels are calculated. There are substantial differences between the spectra of different uranium and plutonium isotopes. On the other hand, the dependence on the energy and flux of the fission inducing neutrons is very weak. The resulting spectra can be used for calculation of the antineutrino and electron spectra of an arbitrary nuclear reactor at various stages of its refueling cycle. The sources of uncertainties in the spectrum are identified and analyzed in detail. The exposure time dependence of the spectrum is also discussed. The resulting anti ν/sub e/ spectra are then used to calculate the averaged cross sections of the inverse neutron β decay, weak charged and neutral current induced deuteron disintegration, and the antineutrino-electron scattering

In situ enzymology of DNA replication and ultraviolet-induced DNA repair synthesis in permeable human cells

International Nuclear Information System (INIS)

Dresler, S.; Frattini, M.G.; Robinson-Hill, R.M.

1988-01-01

Using permeable diploid human fibroblasts, the authors have studied the deoxyribonucleoside triphosphate concentration dependences of ultraviolet- (UV-) induced DNA repair synthesis and semiconservative DNA replication. In both cell types (AG1518 and IMR-90) examined, the apparent K m values for dCTP, dGTP, and dTTP for DNA replication were between 1.2 and 2.9 μM. For UV-induced DNA repair synthesis, the apparent K m values were substantially lower, ranging from 0.11 to 0.44 μM for AG1518 cells and from 0.06 to 0.24 μM for IMR-90 cells. Recent data implicate DNA polymerase δ in UV-induced repair synthesis and suggest that DNA polymerases α and δ are both involved in semiconservative replication. They measured K m values for dGTP and dTTP for polymerases α and δ, for comparison with the values for replication and repair synthesis. The deoxyribonucleotide K m values for DNA polymerase δ are much greater than the K m values for UV-induced repair synthesis, suggesting that when polymerase δ functions in DNA repair, its characteristics are altered substantially either by association with accessory proteins or by direct posttranslational modification. In contrast, the deoxyribonucleotide binding characteristics of the DNA replication machinery differ little from those of the isolated DNA polymerases. The K m values for UV-induced repair synthesis are 5-80-fold lower than deoxyribonucleotide concentrations that have been reported for intact cultured diploid human fibroblasts. For replication, however, the K m for dGTP is only slightly lower than the average cellular dGTP concentration that has been reported for exponentially growing human fibroblasts. This finding is consistent with the concept that nucleotide compartmentation is required for the attainment of high rates of DNA replication in vivo

Development of a flood-induced health risk prediction model for Africa

Science.gov (United States)

Lee, D.; Block, P. J.

2017-12-01

Globally, many floods occur in developing or tropical regions where the impact on public health is substantial, including death and injury, drinking water, endemic disease, and so on. Although these flood impacts on public health have been investigated, integrated management of floods and flood-induced health risks is technically and institutionally limited. Specifically, while the use of climatic and hydrologic forecasts for disaster management has been highlighted, analogous predictions for forecasting the magnitude and impact of health risks are lacking, as is the infrastructure for health early warning systems, particularly in developing countries. In this study, we develop flood-induced health risk prediction model for African regions using season-ahead flood predictions with climate drivers and a variety of physical and socio-economic information, such as local hazard, exposure, resilience, and health vulnerability indicators. Skillful prediction of flood and flood-induced health risks can contribute to practical pre- and post-disaster responses in both local- and global-scales, and may eventually be integrated into multi-hazard early warning systems for informed advanced planning and management. This is especially attractive for areas with limited observations and/or little capacity to develop flood-induced health risk warning systems.

Polymorphisms of DRD2, DRD3, DRD4 and HTR2C genes in levodopa-induced dyskinesias in Parkinson's disease

NARCIS (Netherlands)

Ivanova, S.A.; Alifirova, V.M.; Fedorenko, O.Y.; Freidin, M.B.; Bokhan, N.A.; Zhukova, I.; Al Hadithy, A.F.Y.; Brouwers, J.R.B.J.; Wilffert, B.; Loonen, A.J.M.

2015-01-01

Levodopa-induced dyskinesias (LID) are involuntary muscle movements that occur as a consequence of chronic levodopa (L-DOPA) treatment. LID are a substantial barrier to effective symptomatic management of Parkinson's disease (PD), up to 45% of L-DOPA users develop LID within 5 years [1]. Clinical

Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases

DEFF Research Database (Denmark)

Reimers, J I; Bjerre, U; Mandrup-Poulsen, T

1994-01-01

Substantial in vitro evidence suggests that nitric oxide may be a major mediator of interleukin 1 (IL-1) induced pancreatic beta-cell inhibition and destruction in the initial events leading to insulin-dependent diabetes mellitus. Using NG-nitro-L-arginine methyl ester, an inhibitor of both...

Antibody-Directed Glucocorticoid Targeting to CD163 in M2-type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes

DEFF Research Database (Denmark)

Svendsen, Pia; Graversen, Jonas Heilskov; Etzerodt, Anders

2017-01-01

Increased consumption of high-caloric carbohydrates contributes substantially to endemic non-alcoholic fatty liver disease in humans, covering a histological spectrum from fatty liver to steatohepatitis. Hypercaloric intake and lipogenetic effects of fructose and endotoxin-driven activation...... changes in rats on a high-fructose diet. The diet induced severe non-alcoholic steatohepatitis (NASH)-like changes within a few weeks but the antibody-drug conjugate strongly reduced inflammation, hepatocyte ballooning, fibrosis, and glycogen deposition. Non-conjugated dexamethasone or dexamethasone...... seems to be a promising approach for safe treatment of fructose-induced liver inflammation....

Beam-induced temperature changes in HVEM irradiations

International Nuclear Information System (INIS)

Garner, F.A.; Thomas, L.E.; Gelles, D.S.

1975-01-01

The peak value of the temperature distribution induced by energy loss of 1.0 MeV electrons in traversing a typical HVEM irradiation specimen can be very substantial. The origin and various features of this distribution were analyzed for a variety of specimen geometries. The major parametric dependencies are shown to be relatively independent of specimen geometry, however, and allow the definition of a scaling relationship that can be employed to predict temperature rises in materials that cannot be measured directly. The use of this scaling relationship requires that the experimenter minimize perturbations of the heat flow due to proximity of the central hole in the specimen. An experimental method of determining directly the magnitude and distribution of beam-induced temperature profiles was developed which utilizes the order-disorder transformation in Fe 3 Al and Cu 3 Au. Scaling of experimentally determined temperature changes leads to more realistic estimates of the total temperature rise than are currently available in various literature tabulations. The factors which determine the optimum selection of irradiation parameters for a given experiment are also discussed

Evaluation of the standard normal variate method for Laser-Induced Breakdown Spectroscopy data treatment applied to the discrimination of painting layers

Science.gov (United States)

Syvilay, D.; Wilkie-Chancellier, N.; Trichereau, B.; Texier, A.; Martinez, L.; Serfaty, S.; Detalle, V.

2015-12-01

Nowadays, Laser-Induced Breakdown Spectroscopy (LIBS) is frequently used for in situ analyses to identify pigments from mural paintings. Nonetheless, in situ analyses require a robust instrumentation in order to face to hard experimental conditions. This may imply variation of fluencies and thus inducing variation of LIBS signal, which degrades spectra and then results. Usually, to overcome these experimental errors, LIBS signal is processed. Signal processing methods most commonly used are the baseline subtraction and the normalization by using a spectral line. However, the latter suggests that this chosen element is a constant component of the material, which may not be the case in paint layers organized in stratigraphic layers. For this reason, it is sometimes difficult to apply this normalization. In this study, another normalization will be carried out to throw off these signal variations. Standard normal variate (SNV) is a normalization designed for these conditions. It is sometimes implemented in Diffuse Reflectance Infrared Fourier Transform Spectroscopy and in Raman Spectroscopy but rarely in LIBS. The SNV transformation is not newly applied on LIBS data, but for the first time the effect of SNV on LIBS spectra was evaluated in details (energy of laser, shot by shot, quantification). The aim of this paper is the quick visualization of the different layers of a stratigraphic painting sample by simple data representations (3D or 2D) after SNV normalization. In this investigation, we showed the potential power of SNV transformation to overcome undesired LIBS signal variations but also its limit of application. This method appears as a promising way to normalize LIBS data, which may be interesting for in-situ depth analyses.

Glucagon-like peptide-1 analogs against antipsychotic-induced weight gain: potential physiological benefits

Science.gov (United States)

2012-01-01

Background Antipsychotic-induced weight gain constitutes a major unresolved clinical problem which may ultimately be associated with reducing life expectancy by 25 years. Overweight is associated with brain deterioration, cognitive decline and poor quality of life, factors which are already compromised in normal weight patients with schizophrenia. Here we outline the current strategies against antipsychotic-induced weight gain, and we describe peripheral and cerebral effects of the gut hormone glucagon-like peptide-1 (GLP-1). Moreover, we account for similarities in brain changes between schizophrenia and overweight patients. Discussion Current interventions against antipsychotic-induced weight gain do not facilitate a substantial and lasting weight loss. GLP-1 analogs used in the treatment of type 2 diabetes are associated with significant and sustained weight loss in overweight patients. Potential effects of treating schizophrenia patients with antipsychotic-induced weight gain with GLP-1 analogs are discussed. Conclusions We propose that adjunctive treatment with GLP-1 analogs may constitute a new avenue to treat and prevent metabolic and cerebral deficiencies in schizophrenia patients with antipsychotic-induced weight gain. Clinical research to support this idea is highly warranted. PMID:22891821

Glucagon-like peptide-1 analogs against antipsychotic-induced weight gain: potential physiological benefits

Directory of Open Access Journals (Sweden)

Ebdrup Bjørn H

2012-08-01

Full Text Available Abstract Background Antipsychotic-induced weight gain constitutes a major unresolved clinical problem which may ultimately be associated with reducing life expectancy by 25 years. Overweight is associated with brain deterioration, cognitive decline and poor quality of life, factors which are already compromised in normal weight patients with schizophrenia. Here we outline the current strategies against antipsychotic-induced weight gain, and we describe peripheral and cerebral effects of the gut hormone glucagon-like peptide-1 (GLP-1. Moreover, we account for similarities in brain changes between schizophrenia and overweight patients. Discussion Current interventions against antipsychotic-induced weight gain do not facilitate a substantial and lasting weight loss. GLP-1 analogs used in the treatment of type 2 diabetes are associated with significant and sustained weight loss in overweight patients. Potential effects of treating schizophrenia patients with antipsychotic-induced weight gain with GLP-1 analogs are discussed. Conclusions We propose that adjunctive treatment with GLP-1 analogs may constitute a new avenue to treat and prevent metabolic and cerebral deficiencies in schizophrenia patients with antipsychotic-induced weight gain. Clinical research to support this idea is highly warranted.

Throwing computing into reverse

Energy Technology Data Exchange (ETDEWEB)

Frank, Michael P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-09-01

For more than 50 years, computers have made steady and dramatic improvements, all thanks to Moore’s Law—the exponential increase over time in the number of transistors that can be fabricated on an integrated circuit of a given size. Moore’s Law owed its success to the fact that as transistors were made smaller, they became simultaneously cheaper, faster, and more energy efficient. The payoff from this win-win-win scenario enabled reinvestment in semiconductor fabrication technology that could make even smaller, more densely-packed transistors. And so this virtuous cycle continued, decade after decade. Now though, experts in industry, academia, and government laboratories anticipate that semiconductor miniaturization won’t continue much longer—maybe 10 years or so, at best. Making transistors smaller no longer yields the improvements it used to. The physical characteristics of small transistors forced clock speeds to cease getting faster more than a decade ago, which drove the industry to start building chips with multiple cores. But even multi-core architectures must contend with increasing amounts of “dark silicon,” areas of the chip that must be powered off to avoid overheating.

Pay as you throw

International Nuclear Information System (INIS)

Dahlen, Lisa; Lagerkvist, Anders

2010-01-01

Householders' response to weight-based billing for the collection of household waste was investigated with the aim of providing decision support for waste management policies. Three questions were addressed: How much and what kind of information on weight-based billing is discernible in generic Swedish waste collection statistics? Why do local authorities implement weight-based billing, and how do they perceive the results? and, Which strengths and weaknesses of weight-based billing have been observed on the local level? The study showed that municipalities with pay-by-weight schemes collected 20% less household waste per capita than other municipalities. Surprisingly, no part of this difference could be explained by higher recycling rates. Nevertheless, the majority of waste management professionals were convinced that recycling had increased as a result of the billing system. A number of contradicting strengths and weaknesses of weight-based billing were revealed.

Sensitivity Analysis for Assessing Effects of Tree Population Dynamics on Soil Bioturbation

Science.gov (United States)

Martin, Y. E.; Johnson, E. A.

2012-12-01

Bioturbation due to tree root throw is thought to be an important process in soil production and soil mixing. Despite progress in our understanding of root throw processes, the tree population dynamics affecting the occurrence and timing of root throw events remain much less well explained. Unfortunately, research about forest dynamics is not always undertaken from the perspective of those interested in tree death, tree topple and associated root throw. As a result, the necessary field data about tree population dynamics is often unavailable for many locations. The acquisition of such data would allow for improved interpretation of root throw observations and for incorporation within numerical models of tree root throw occurrence. The present study uses our earlier tree population dynamics model calibrated for subalpine forests in the Canadian Rockies to test the sensitivity of forest parameters within the model that determine tree death, tree topple, root throw and soil bioturbation. Crown wildfire disturbance is the primary driver of tree population dynamics, with wind throw being mainly of local importance. The recruitment and mortality of trees during multiple generations of forest determine the number of live trees on the landscape at any given time. Tree death may occur due to competition/thinning of trees between wildfire events or as a result of the wildfire itself. Unless trees die due to sudden wind throw events (as mentioned above, this is only of local significance in our study area), they remain standing for some time period after tree death and before tree topple; these trees are referred to as standing dead trees. The duration of this time window and several other factors influence if a tree breaks at its base or upheaves a relatively intact root plate with attached sediment. Our field research has also suggested that a minimum dbh is required before a root plate is large enough to upheave notable amounts of sediment. Modelling results in this study

Simple Multiplexing Hand-Held Control Unit

Science.gov (United States)

Hannaford, Blake

1989-01-01

Multiplexer consists of series of resistors, each shunted by single-pole, single-throw switch. User operates switches by pressing buttons or squeezing triggers. Prototype includes three switches operated successfully in over 200 hours of system operations. Number of switches accommodated determined by signal-to-noise ratio of current source, noise induced in control unit and cable, and number of bits in output of analog-to-digital converter. Because many computer-contolled robots have extra analog-to-digital channels, such multiplexer added at little extra cost.

Influence of judoka height when using the seoi nage technique

Directory of Open Access Journals (Sweden)

Sebastião Iberes Lopes Melo

2013-06-01

Full Text Available DOI: http://dx.doi.org/10.5007/1980-0037.2013v15n5p578 Judo techniques use the assumption of maximum efficiency with minimum energy expenditure, which means to try to use the strength of the opponent against himself, causing an imbalance that, associated with a technique, helps execute a throw. This study is aimed to evaluate the mechanical efficiency of the seoi nage technique applied to judokas (uke of different heights in relation to the thrower (tori. The knee and trunk angular variation of tori was compared with the total throw time, the time to perform each phase of the technique, and the behavior and vertical variation of the trajectory of tori’s center of mass (ΔCM. Ten throws using the seoi nage technique on three uke of shorter, equivalent, and taller statures compared to tori were cinematically analyzed. Theimages were recorded at 180 Hz using the Peak Motus System. The data was analyzed by descriptive statistics, ANOVA, and Tukey’s post-hoc (p < 0.05. The tori’s mechanical efficiency was greater when throwing a uke of a stature taller or of his same height, while the total throw time was shorter for a taller uke. The ΔCM of the tori was greater to throw a uke of a shorter stature. The conclusion is that the seoi nage technique is most effective when applied against opponents of heights equal to or taller than the tori.

The thrower's elbow.

Science.gov (United States)

Patel, Ronak M; Lynch, T Sean; Amin, Nirav H; Calabrese, Gary; Gryzlo, Stephen M; Schickendantz, Mark S

2014-07-01

Overhead throwing activities expose the elbow to tremendous valgus stress, making athletes vulnerable to a specific constellation of injuries. Although baseball players, in particular pitchers, are the athletes affected most commonly, overhead throwing athletes in football, volleyball, tennis, and javelin tossing also are affected. The purpose of this review is to review the anatomy, biomechanics, pathophysiology, and treatment of elbow disorders related to overhead throwing athletes. Although focus is on management of ulnar collateral ligament injuries, all common pathologies are discussed. Copyright © 2014 Elsevier Inc. All rights reserved.

Low dose radiation induced protein and its effect on expression of CD25 molecule in lymphocytes

International Nuclear Information System (INIS)

Lu Duicai; Su Liaoyuan

2001-01-01

Objective: To find the substantial basis for effects of low dose radiation, on development, extraction, and the biogical activity of the low-dose radiation-induced proteins, and the effects of LDR induced proteins on CD25 molecule expression of human lymphocytes. Methods: 1. Healthy Kumning male mice exposed to radiation of 226 Ra γ-rays at 5, 10 and 15 cGy respectively. The mice were killed 2 hours after exposure, the spleen cells were broken with ultrasonic energy and then ultra-centrifugalized at low temperature (4 degree C). The LDR-induced proteins were obtained in the supernatant solution. Then the changes of CD25 molecule was measured by flow cytometry (FCM) with immunofluorescence technique, which was used to reflect the effect of LDR induced proteins on CD25 molecule expression of human lymphocytes. Results: LDR induced proteins were obtained from spleen cells in mice exposed to 5-15 cGy whole body radiation. Conclusion: The expression of CD25 molecule of lymphocytes was increased significantly after use of LDR induced proteins. LDR induced proteins can enhance expression of CD25 molecule of lymphocytes slightly

Substantiation of the safety in the technical project of Belene NPP

International Nuclear Information System (INIS)

Boyadzhiev, A.

1990-01-01

The chapter contains an evaluation of the safety of Belene NPP project, based on an experts study of the corresponding volume of the Technical Project documentation of the main contractor and also on other related documents. The authors state that most of the remarks are constitutive, part of them requiring additional information or research. The general explicit conclusion is that the materials on the safety substantiation provided in the project are insufficient for making final statements on the safety of the NPP and there is a need for a detailed analysis and expertise. There are 12 topical conclusion paragraphs and each of them comprises a number of remarks. Among the remarks there are some related to the reactivity coefficient values in certain modes of operation, the problem of the mechanical safety and control system efficiency, the unacceptable operation at nominal power in case of stringent safety rules enforcement, the insufficiency of the PSA, the automatic control systems and the software codes not standing up to the contemporary requirements. (R.Ts.)

The contribution of benzene to smoking-induced leukemia.

Science.gov (United States)

Korte, J E; Hertz-Picciotto, I; Schulz, M R; Ball, L M; Duell, E J

2000-04-01

Cigarette smoking is associated with an increased risk of leukemia; benzene, an established leukemogen, is present in cigarette smoke. By combining epidemiologic data on the health effects of smoking with risk assessment techniques for low-dose extrapolation, we assessed the proportion of smoking-induced total leukemia and acute myeloid leukemia (AML) attributable to the benzene in cigarette smoke. We fit both linear and quadratic models to data from two benzene-exposed occupational cohorts to estimate the leukemogenic potency of benzene. Using multiple-decrement life tables, we calculated lifetime risks of total leukemia and AML deaths for never, light, and heavy smokers. We repeated these calculations, removing the effect of benzene in cigarettes based on the estimated potencies. From these life tables we determined smoking-attributable risks and benzene-attributable risks. The ratio of the latter to the former constitutes the proportion of smoking-induced cases attributable to benzene. Based on linear potency models, the benzene in cigarette smoke contributed from 8 to 48% of smoking-induced total leukemia deaths [95% upper confidence limit (UCL), 20-66%], and from 12 to 58% of smoking-induced AML deaths (95% UCL, 19-121%). The inclusion of a quadratic term yielded results that were comparable; however, potency models with only quadratic terms resulted in much lower attributable fractions--all models substantially overestimate low-dose risk, linear extrapolations from empirical data over a dose range of 10- to 100-fold resulted in plausible predictions.

Effect of amiodarone-induced hyperthyroidism on left ventricular outflow obstruction after septal myectomy for hypertrophic cardiomyopathy.

Science.gov (United States)

Pokorney, Sean D; Stone, Neil J; Passman, Rod; Oyer, David; Rigolin, Vera H; Bonow, Robert O

2010-12-01

Patients with obstructive hypertrophic cardiomyopathy who undergo septal myectomy are at risk for developing postoperative atrial fibrillation. Amiodarone is effective in treating this arrhythmia but is associated with multiple adverse effects, often with delayed onset. A novel case is described of a patient who developed type 2 amiodarone-induced hyperthyroidism that presented as recurrence of outflow obstruction after septal myectomy. The patient's symptoms and echocardiographic findings of outflow obstruction resolved substantially with the treatment of the amiodarone-induced hyperthyroidism. Amiodarone-induced hyperthyroidism of delayed onset can be a subtle diagnosis, requiring a high index of suspicion. In conclusion, recognition of this diagnosis in patients with recurrence of outflow obstruction by symptoms and cardiac imaging after septal myectomy may avoid unnecessary repeat surgical intervention. Copyright © 2010 Elsevier Inc. All rights reserved.

US -endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia

Energy Technology Data Exchange (ETDEWEB)

Nicolas, P.; Li, C.H.

1985-05-01

The potent opioid peptide US -endorphin is found in the brain and pituitary with two related fragments, US -endorphin-(1-27) and US -endorphin-(1-26). The fragments, retain substantial opioid-receptor binding activity but are virtually inactive analgesically. US -Endorphin-(1-27) inhibits US -endorphin-induced and etorphine-induced analgesia when coinjected intracerebroventricularly into mice. Antagonism by competition at the same site(s) is suggested from parallel shifts of the dose-response curves of etorphine or US -endorphin in the presence of US -endorphin-(1-27). Its potency is 4-5 times greater than that of the opiate antagonist naloxone. US -Endorphin-(1-26) does not antagonize the antinociceptive action of etorphine or US -endorphin in doses up to 500 pmol per animal.

Comparison of strategies for substantiating freedom from scrapie in a sheep flock.

Science.gov (United States)

Durand, Benoit; Martinez, Marie-José; Calavas, Didier; Ducrot, Christian

2009-04-30

The public health threat represented by a potential circulation of bovine spongiform encephalopathy agent in sheep population has led European animal health authorities to launch large screening and genetic selection programmes. If demonstrated, such a circulation would have dramatic economic consequences for sheep breeding sector. In this context, it is important to evaluate the feasibility of qualification procedures that would allow sheep breeders demonstrating their flock is free from scrapie. Classical approaches, based on surveys designed to detect disease presence, do not account for scrapie specificities: the genetic variations of susceptibility and the absence of live diagnostic test routinely available. Adapting these approaches leads to a paradoxical situation in which a greater amount of testing is needed to substantiate disease freedom in genetically resistant flocks than in susceptible flocks, whereas probability of disease freedom is a priori higher in the former than in the latter. The goal of this study was to propose, evaluate and compare several qualification strategies for demonstrating a flock is free from scrapie. A probabilistic framework was defined that accounts for scrapie specificities and allows solving the preceding paradox. Six qualification strategies were defined that combine genotyping data, diagnostic tests results and flock pedigree. These were compared in two types of simulated flocks: resistant and susceptible flocks. Two strategies allowed demonstrating disease freedom in several years, for the majority of simulated flocks: a strategy in which all the flock animals are genotyped, and a strategy in which only founders animals are genotyped, the flock pedigree being known. In both cases, diagnostic tests are performed on culled animals. The less costly strategy varied according to the genetic context (resistant or susceptible) and to the relative costs of a genotyping exam and of a diagnostic test. This work demonstrates that

Dopamine mediated iron release from ferritin is enhanced at higher temperatures: Possible implications for fever-induced Parkinson's disease

International Nuclear Information System (INIS)

Babincova, Melania; Babinec, Peter

2005-01-01

A new molecular mechanism is proposed to explain the pathogenesis of fever-induced Parkinson's disease. This proposal is based on dopamine and 6-hydroxydopamine-mediated free iron release from ferritin magnetic nanoparticles, which is enhanced at higher temperatures, and which may lead to substantial peroxidation and injury of lipid biomembranes of the substantia nigra in the brain

Genetic Correction and Hepatic Differentiation of Hemophilia B-specific Human Induced Pluripotent Stem Cells.

Science.gov (United States)

He, Qiong; Wang, Hui-Hui; Cheng, Tao; Yuan, Wei-Ping; Ma, Yu-Po; Jiang, Yong-Ping; Ren, Zhi-Hua

2017-09-27

Objective To genetically correct a disease-causing point mutation in human induced pluripotent stem cells (iPSCs) derived from a hemophilia B patient. Methods First, the disease-causing mutation was detected by sequencing the encoding area of human coagulation factor IX (F IX) gene. Genomic DNA was extracted from the iPSCs, and the primers were designed to amplify the eight exons of F IX. Next, the point mutation in those iPSCs was genetically corrected using CRISPR/Cas9 technology in the presence of a 129-nucleotide homologous repair template that contained two synonymous mutations. Then, top 8 potential off-target sites were subsequently analyzed using Sanger sequencing. Finally, the corrected clones were differentiated into hepatocyte-like cells, and the secretion of F IX was validated by immunocytochemistry and ELISA assay. Results The cell line bore a missense mutation in the 6 th coding exon (c.676 C>T) of F IX gene. Correction of the point mutation was achieved via CRISPR/Cas9 technology in situ with a high efficacy at about 22% (10/45) and no off-target effects detected in the corrected iPSC clones. F IX secretion, which was further visualized by immunocytochemistry and quantified by ELISA in vitro, reached about 6 ng/ml on day 21 of differentiation procedure. Conclusions Mutations in human disease-specific iPSCs could be precisely corrected by CRISPR/Cas9 technology, and corrected cells still maintained hepatic differentiation capability. Our findings might throw a light on iPSC-based personalized therapies in the clinical application, especially for hemophilia B.

Substantial improvements not seen in health behaviors following corner store conversions in two Latino food swamps

OpenAIRE

Ortega, Alexander N.; Albert, Stephanie L.; Chan-Golston, Alec M.; Langellier, Brent A.; Glik, Deborah C.; Belin, Thomas R.; Garcia, Rosa Elena; Brookmeyer, Ron; Sharif, Mienah Z.; Prelip, Michael L.

2016-01-01

Background The effectiveness of food retail interventions is largely undetermined, yet substantial investments have been made to improve access to healthy foods in food deserts and swamps via grocery and corner store interventions. This study evaluated the effects of corner store conversions in East Los Angeles and Boyle Heights, California on perceived accessibility of healthy foods, perceptions of corner stores, store patronage, food purchasing, and eating behaviors. Methods Household data ...

Noise-induced hearing loss in small-scale metal industry in Nepal.

Science.gov (United States)

Whittaker, J D; Robinson, T; Acharya, A; Singh, D; Smith, M

2014-10-01

There has been no previous research to demonstrate the risk of noise-induced hearing loss in industry in Nepal. Limited research on occupational noise-induced hearing loss has been conducted within small-scale industry worldwide, despite it being a substantial and growing cause of deafness in the developing world. The study involved a cross-sectional audiometric assessment, with questionnaire-based examinations of noise and occupational history, and workplace noise level assessment. A total of 115 metal workers and 123 hotel workers (control subjects) were recruited. Noise-induced hearing loss prevalence was 30.4 per cent in metal workers and 4.1 per cent in hotel workers, with a significant odds ratio of 10.3. Except for age and time in occupation, none of the demographic factors were significant in predicting outcomes in regression analyses. When adjusted for this finding, and previous noise-exposed occupations, the odds ratio was 13.8. Workplace noise was significantly different between the groups, ranging from 65.3 to 84.7 dBA in metal worker sites, and from 51.4 to 68.6 dBA in the control sites. Metal workers appear to have a greater risk of noise-induced hearing loss than controls. Additional research on occupational noise-induced hearing loss in Nepal and small-scale industry globally is needed.

Inducible transgenics. New lessons on events governing the induction and commitment in mammary tumorigenesis

International Nuclear Information System (INIS)

Hulit, James; Di Vizio, Dolores; Pestell, Richard G

2001-01-01

Breast cancer arises from multiple genetic events that together contribute to the established, irreversible malignant phenotype. The development of inducible tissue-specific transgenics has allowed a careful dissection of the events required for induction and subsequent maintenance of tumorigenesis. Mammary gland targeted expression of oncogenic Ras or c-Myc is sufficient for the induction of mammary gland tumorigenesis in the rodent, and when overexpressed together the rate of tumor onset is substantially enhanced. In an exciting recent finding, D'Cruz et al discovered tetracycline-regulated c-Myc overexpression in the mammary gland induced invasive mammary tumors that regressed upon withdrawal of c-Myc expression. Almost one-half of the c-Myc-induced tumors harbored K-ras or N-ras gene point mutations, correlating with tumor persistence on withdrawal of c-Myc transgene expression. These findings suggest maintenance of tumorigenesis may involve a second mutation within the Ras pathway

A review of factors influencing the incidence and severity of plaque-induced gingivitis.

Science.gov (United States)

Trombelli, L; Farina, R

2013-06-01

An individual variation in the gingival inflammatory response to the dental biofilm has been demonstrated. This variability can be observed between individuals with neither quantitative nor qualitative differences in plaque accumulation. The reported significant differences in gingival inflammatory response under quantitatively and/or qualitatively almost identical bacterial challenge suggest that the gingival response to plaque accumulation may be an individual trait, possibly genetic in origin. The most recent classification of periodontal diseases acknowledges that the clinical expression of plaque-induced gingival inflammation can be substantially modified by systemic factors, either inherent to the host or related to environmental influences. The aim of the present literature review is to describe (i) the factors influencing the development of plaque-induced gingivitis as well as (ii) those metabolic, environmental and systemic factors which have a direct impact on the etiopathogenetic pathway of plaque-induced gingivitis, thus altering the nature or course of the gingival inflammatory response to dental biofilm.

Are Composers Different? Historical Evidence on Conflict-induced Migration (1816-1997)

DEFF Research Database (Denmark)

Borowiecki, Karol

2012-01-01

In this paper we explore whether, and to what extent, the incidence of war affects the migration intensity of 164 prominent classical composers born after 1800. We model the aggregate stock of composers in a country and find that periods of war correspond negatively with the number of artists. We...... also find that conflict-induced migration intensity is considerably higher for composers than for the overall population and demonstrate that the share of composers in the overall population drops due to the incidence of war. We further find that the observed outmigration substantially diminishes...

Self-screening of the quantum confined Stark effect by the polarization induced bulk charges in the quantum barriers

International Nuclear Information System (INIS)

Zhang, Zi-Hui; Liu, Wei; Ju, Zhengang; Tiam Tan, Swee; Ji, Yun; Kyaw, Zabu; Zhang, Xueliang; Wang, Liancheng; Wei Sun, Xiao; Volkan Demir, Hilmi

2014-01-01

InGaN/GaN light-emitting diodes (LEDs) grown along the polar orientations significantly suffer from the quantum confined Stark effect (QCSE) caused by the strong polarization induced electric field in the quantum wells, which is a fundamental problem intrinsic to the III-nitrides. Here, we show that the QCSE is self-screened by the polarization induced bulk charges enabled by designing quantum barriers. The InN composition of the InGaN quantum barrier graded along the growth orientation opportunely generates the polarization induced bulk charges in the quantum barrier, which well compensate the polarization induced interface charges, thus avoiding the electric field in the quantum wells. Consequently, the optical output power and the external quantum efficiency are substantially improved for the LEDs. The ability to self-screen the QCSE using polarization induced bulk charges opens up new possibilities for device engineering of III-nitrides not only in LEDs but also in other optoelectronic devices.

Self-screening of the quantum confined Stark effect by the polarization induced bulk charges in the quantum barriers

Energy Technology Data Exchange (ETDEWEB)

Zhang, Zi-Hui; Liu, Wei; Ju, Zhengang; Tiam Tan, Swee; Ji, Yun; Kyaw, Zabu; Zhang, Xueliang; Wang, Liancheng; Wei Sun, Xiao, E-mail: exwsun@ntu.edu.sg, E-mail: volkan@stanfordalumni.org [LUMINOUS Centre of Excellence for Semiconductor Lighting and Displays, School of Electrical and Electronic Engineering, School of Physical and Mathematical Sciences, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (Singapore); Volkan Demir, Hilmi, E-mail: exwsun@ntu.edu.sg, E-mail: volkan@stanfordalumni.org [LUMINOUS Centre of Excellence for Semiconductor Lighting and Displays, School of Electrical and Electronic Engineering, School of Physical and Mathematical Sciences, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (Singapore); Department of Electrical and Electronics, Department of Physics, and UNAM-Institute of Material Science and Nanotechnology, Bilkent University, TR-06800 Ankara (Turkey)

2014-06-16

InGaN/GaN light-emitting diodes (LEDs) grown along the polar orientations significantly suffer from the quantum confined Stark effect (QCSE) caused by the strong polarization induced electric field in the quantum wells, which is a fundamental problem intrinsic to the III-nitrides. Here, we show that the QCSE is self-screened by the polarization induced bulk charges enabled by designing quantum barriers. The InN composition of the InGaN quantum barrier graded along the growth orientation opportunely generates the polarization induced bulk charges in the quantum barrier, which well compensate the polarization induced interface charges, thus avoiding the electric field in the quantum wells. Consequently, the optical output power and the external quantum efficiency are substantially improved for the LEDs. The ability to self-screen the QCSE using polarization induced bulk charges opens up new possibilities for device engineering of III-nitrides not only in LEDs but also in other optoelectronic devices.

THE USE OF TEACHING METHODS IN CLASS MAIN PART OF THE PHYSICAL EDUCATION

Directory of Open Access Journals (Sweden)

Enver Međedović

2008-08-01

Full Text Available Physical education as compulsory form of education has its own structure, which has different structure from the other subjects. The differences are especially spotted throw metodicalad mission, also throw working methods which are different, dipending of unit which has been done, method which will be used in main or simple part of class depends on aims and subject matters of cimesiolical operaters (these are simple teaching aids, it also dependes of age and sex, depends of relation between teacher and pupil and of course of laws on which is built this subject. Throw empirical researches on representativle sample of 56 home room teachers, it showed that the most used method is demonstrative and it also showed the importance of methods which are used in this subject. These results which are gained throw instrumental researches of questionnaire, are represented in charts, graphics and texts.

Radiostrontium-induced oncogenesis and the role of immunosuppression. Pt. 2

International Nuclear Information System (INIS)

Bierke, P.; Nilsson, A.

1990-01-01

The significance of depressed immune function for the development and progression of tumours induced by 90 Sr (mainly osteosarcomas and malignant lymphomas) was investigated in a series of experiments by comparing the tumour responses in normal mice with those in immunocompromised mice. The present paper (part II) reports on lympho-reticular (LR) and extraskeletal neoplastic lesions in male CBA/SU mice after exposure to different single doses of 90 Sr with or without additional immunosuppression by adult thymectomy (ATx) and/or prolonged antilymphocyteglobulin (ALG) treatment. Neoplastic lesions in bone were reported in part I. The status of the animal's immune system and responsive ability were examined in parallel experiments. The tumor yields were analysed in relation to the dosage of 90 Sr and the immunosuppressive treatments employed. Although the incidences and latency times of induced tumours were clearly dose-dependent, they were never significantly influenced by ATx/ALG treatments. Thus, no substantial support was gained for the theory that the immune system plays a controlling or modifying role in 90 Sr carcinogenesis. The results, which are in agreement with the bone tumour responses, suggest that 90 Sr induced tumours either do not express the antigens necessary for immune rejection or that the decline in immune responsiveness induced by ATx/ALG was of little consequence for tumour development and spread. The pathogenesis of 90 Sr induced malignant lymphomas (MLs) and their immunophenotypes are discussed. (orig.)

Shear-induced phase changes in mixtures

International Nuclear Information System (INIS)

Romig, K.D.; Hanley, H.J.M.

1986-01-01

A thermodynamic theory to account for the behavior of liquid mixtures exposed to a shear is developed. One consequence of the theory is that shear-induced phase changes are predicted. The theory is based on a thermodynamics that includes specifically the shear rate in the formalism and is applied to mixtures by a straightforward modification of the corresponding states, conformalsolution approach. The approach is general but is used here for a mixture of Lennard-Jones particles with a Lennard-Jones equation of state as a reference fluid. The results are discussed in the context of the Scott and Van Konynenberg phase classification. It is shown that the influence of a shear does affect substantially the type of the phase behavior. Results from the model mixture are equated loosely with those from real polymeric liquids

Mechanisms of cell death induced by infusion sets leachables in in vitro experimental settings.

Science.gov (United States)

Kozlovskaya, Luba; Stepensky, David

2015-01-30

Leachable materials that are released from infusion sets during their use can induce local and systemic toxic effects. We studied the mechanisms and kinetics of cell death induced by infusion sets leachates in vitro using L-929 and bEnd. 3 cells. Changes in cell morphology and metabolic activity were determined using light microscopy and the MTT test, respectively. Detailed analysis of the mechanisms of cell death was performed using membrane integrity and caspases 3 and 7 activity tests, annexin V-FITC/7-AAD analysis by FACS, and DAPI nuclear staining followed by confocal microscopy. Infusion sets released toxic leachables and induced toxic effects. Latex flashball was the most toxic part of the studied infusion sets, and it potently induced cell oncosis via increased permeability of the cell membrane. Latex-induced decrease in cells metabolic activity and cell death were not accompanied by activation of caspases 3 and 7, changes in nuclear morphology, or substantial annexin V-FITC cell staining. Leachables from the tube part of the infusion sets were less toxic, and induced some biochemical changes without altering the cells morphology. Further studies are needed to reveal the in vivo toxicity of infusion sets and its correlation with the results of in vitro toxicity studies. Copyright © 2014 Elsevier B.V. All rights reserved.

Multimodal exercise training in multiple sclerosis: A randomized controlled trial in persons with substantial mobility disability.

Science.gov (United States)

Sandroff, Brian M; Bollaert, Rachel E; Pilutti, Lara A; Peterson, Melissa L; Baynard, Tracy; Fernhall, Bo; McAuley, Edward; Motl, Robert W

2017-10-01

Mobility disability is a common, debilitating feature of multiple sclerosis (MS). Exercise training has been identified as an approach to improve MS-related mobility disability. However, exercise randomized controlled trials (RCTs) on mobility in MS have generally not selectively targeted those with the onset of irreversible mobility disability. The current multi-site RCT compared the efficacy of 6-months of supervised, multimodal exercise training with an active control condition for improving mobility, gait, physical fitness, and cognitive outcomes in persons with substantial MS-related mobility disability. 83 participants with substantial MS-related mobility disability underwent initial mobility, gait, fitness, and cognitive processing speed assessments and were randomly assigned to 6-months of supervised multimodal (progressive aerobic, resistance, and balance) exercise training (intervention condition) or stretching-and-toning activities (control condition). Participants completed the same outcome assessments halfway through and immediately following the 6-month study period. There were statistically significant improvements in six-minute walk performance (F(2158)=3.12, p=0.05, η p 2 =0.04), peak power output (F(2150)=8.16, pmobility disability. This is critical for informing the development of multi-site exercise rehabilitation programs in larger samples of persons with MS-related mobility disability. Copyright © 2017 Elsevier Inc. All rights reserved.

‘The prehistory of Asian collections in Paris’: Ting Chang, Travel, Collecting, and Museums of Asian Art in Nineteenth-Century Paris, Aldershot: Ashgate 2013

Directory of Open Access Journals (Sweden)

Partha Mitter

2014-12-01

Full Text Available The work deals with three major collectors of Asian art in Paris in the 19th century. Enrico Cernuschi and Émile Guimet (founder of Musée Guimet acquired their substantial collection through travelling abroad while Edmond Goncourt amassed his collection at home through dealers. As the author argues, the influential postcolonial critiques of museum collections as instruments of power and authority do not take into account labour and social relations, and somatic experiences of travels to Asia. Cross-cultural encounters between Europe and Asia led to subtle inversions of power, undermining European sense of superiority. Additionally, she throws light on extensive networks and complex political, commercial, monetary relations, especially bimetallism, as well as the material conditions that affect art collection.

Substantial soil organic carbon retention along floodplains of mountain streams

Science.gov (United States)

Sutfin, Nicholas A.; Wohl, Ellen

2017-07-01

Small, snowmelt-dominated mountain streams have the potential to store substantial organic carbon in floodplain sediment because of high inputs of particulate organic matter, relatively lower temperatures compared with lowland regions, and potential for increased moisture conditions. This work (i) quantifies mean soil organic carbon (OC) content along 24 study reaches in the Colorado Rocky Mountains using 660 soil samples, (ii) identifies potential controls of OC content based on soil properties and spatial position with respect to the channel, and (iii) and examines soil properties and OC across various floodplain geomorphic features in the study area. Stepwise multiple linear regression (adjusted r2 = 0.48, p sample depth, percent sand, distance from the channel, and relative elevation from the channel are significant predictors of OC content in the study area. Principle component analysis indicates limited separation between geomorphic floodplain features based on predictors of OC content. A lack of significant differences among floodplain features suggests that the systematic random sampling employed in this study can capture the variability of OC across floodplains in the study area. Mean floodplain OC (6.3 ± 0.3%) is more variable but on average greater than values in uplands (1.5 ± 0.08% to 2.2 ± 0.14%) of the Colorado Front Range and higher than published values from floodplains in other regions, particularly those of larger rivers.

Cat's claw oxindole alkaloid isomerization induced by common extraction methods

Directory of Open Access Journals (Sweden)

Samuel Kaiser

2013-01-01

Full Text Available Cat's claw oxindole alkaloids are prone to isomerization in aqueous solution. However, studies on their behavior in extraction processes are scarce. This paper addressed the issue by considering five commonly used extraction processes. Unlike dynamic maceration (DM and ultrasound-assisted extraction, substantial isomerization was induced by static maceration, turbo-extraction and reflux extraction. After heating under reflux in DM, the kinetic order of isomerization was established and equations were fitted successfully using a four-parameter Weibull model (R² > 0.999. Different isomerization rates and equilibrium constants were verified, revealing a possible matrix effect on alkaloid isomerization.

A Critical Appraisal of RAFT-Mediated Polymerization-Induced Self-Assembly

Science.gov (United States)

2016-01-01

Recently, polymerization-induced self-assembly (PISA) has become widely recognized as a robust and efficient route to produce block copolymer nanoparticles of controlled size, morphology, and surface chemistry. Several reviews of this field have been published since 2012, but a substantial number of new papers have been published in the last three years. In this Perspective, we provide a critical appraisal of the various advantages offered by this approach, while also pointing out some of its current drawbacks. Promising future research directions as well as remaining technical challenges and unresolved problems are briefly highlighted. PMID:27019522

Unaccounted Workload Factor: Game-Day Pitch Counts in High School Baseball Pitchers—An Observational Study

Science.gov (United States)

Zaremski, Jason L.; Zeppieri, Giorgio; Jones, Deborah L.; Tripp, Brady L.; Bruner, Michelle; Vincent, Heather K.; Horodyski, MaryBeth

2018-01-01

Background: Throwing injuries are common in high school baseball. Known risk factors include excessive pitch counts, year-round pitching, and pitching with arm pain and fatigue. Despite the evidence, the prevalence of pitching injuries among high school players has not decreased. One possibility to explain this pattern is that players accumulate unaccounted pitch volume during warm-up and bullpen activity, but this has not yet been examined. Hypotheses: Our primary hypothesis was that approximately 30% to 40% of pitches thrown off a mound by high school pitchers during a game-day outing are unaccounted for in current data but will be revealed when bullpen sessions and warm-up pitches are included. Our secondary hypothesis was that there is wide variability among players in the number of bullpen pitches thrown per outing. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Researchers counted all pitches thrown off a mound during varsity high school baseball games played by 34 high schools in North Central Florida during the 2017 season. Results: We recorded 13,769 total pitches during 115 varsity high school baseball starting pitcher outings. The mean ± SD pitch numbers per game were calculated for bullpen activity (27.2 ± 9.4), warm-up (23.6 ±8.0), live games (68.9 ±19.7), and total pitches per game (119.7 ± 27.8). Thus, 42.4% of the pitches performed were not accounted for in the pitch count monitoring of these players. The number of bullpen pitches thrown varied widely among players, with 25% of participants in our data set throwing fewer than 22 pitches and 25% throwing more than 33 pitches per outing. Conclusion: In high school baseball players, pitch count monitoring does not account for the substantial volume of pitching that occurs during warm-up and bullpen activity during the playing season. These extra pitches should be closely monitored to help mitigate the risk of overuse injury. PMID:29662911

Unaccounted Workload Factor: Game-Day Pitch Counts in High School Baseball Pitchers-An Observational Study.

Science.gov (United States)

Zaremski, Jason L; Zeppieri, Giorgio; Jones, Deborah L; Tripp, Brady L; Bruner, Michelle; Vincent, Heather K; Horodyski, MaryBeth

2018-04-01

Throwing injuries are common in high school baseball. Known risk factors include excessive pitch counts, year-round pitching, and pitching with arm pain and fatigue. Despite the evidence, the prevalence of pitching injuries among high school players has not decreased. One possibility to explain this pattern is that players accumulate unaccounted pitch volume during warm-up and bullpen activity, but this has not yet been examined. Our primary hypothesis was that approximately 30% to 40% of pitches thrown off a mound by high school pitchers during a game-day outing are unaccounted for in current data but will be revealed when bullpen sessions and warm-up pitches are included. Our secondary hypothesis was that there is wide variability among players in the number of bullpen pitches thrown per outing. Cross-sectional study; Level of evidence, 3. Researchers counted all pitches thrown off a mound during varsity high school baseball games played by 34 high schools in North Central Florida during the 2017 season. We recorded 13,769 total pitches during 115 varsity high school baseball starting pitcher outings. The mean ± SD pitch numbers per game were calculated for bullpen activity (27.2 ± 9.4), warm-up (23.6 ±8.0), live games (68.9 ±19.7), and total pitches per game (119.7 ± 27.8). Thus, 42.4% of the pitches performed were not accounted for in the pitch count monitoring of these players. The number of bullpen pitches thrown varied widely among players, with 25% of participants in our data set throwing fewer than 22 pitches and 25% throwing more than 33 pitches per outing. In high school baseball players, pitch count monitoring does not account for the substantial volume of pitching that occurs during warm-up and bullpen activity during the playing season. These extra pitches should be closely monitored to help mitigate the risk of overuse injury.

Progressive skeletal benefits of physical activity when young as assessed at the midshaft humerus in male baseball players.

Science.gov (United States)

Warden, S J; Weatherholt, A M; Gudeman, A S; Mitchell, D C; Thompson, W R; Fuchs, R K

2017-07-01

Physical activity benefits the skeleton, but there is contrasting evidence regarding whether benefits differ at different stages of growth. The current study demonstrates that physical activity should be encouraged at the earliest age possible and be continued into early adulthood to gain most skeletal benefits. The current study explored physical activity-induced bone adaptation at different stages of somatic maturity by comparing side-to-side differences in midshaft humerus properties between male throwing athletes and controls. Throwers present an internally controlled model, while inclusion of control subjects removes normal arm dominance influences. Throwing athletes (n = 90) and controls (n = 51) were categorized into maturity groups (pre, peri, post-early, post-mid, and post-late) based on estimated years from peak height velocity (10 years). Side-to-side percent differences in midshaft humerus cortical volumetric bone mineral density (Ct.vBMD) and bone mineral content (Ct.BMC); total (Tt.Ar), medullary (Me.Ar), and cortical (Ct.Ar) areas; average cortical thickness (Ct.Th); and polar Strength Strain Index (SSI P ) were assessed. Significant interactions between physical activity and maturity on side-to-side differences in Ct.BMC, Tt.Ar, Ct.Ar, Me.Ar, Ct.Th, and SSI P resulted from the following: (1) greater throwing-to-nonthrowing arm differences than dominant-to-nondominant arm differences in controls (all p benefits beginning prior to and continuing beyond somatic maturation and that a longer duration of exposure to physical activity has cumulative skeletal benefits. Thus, physical activity should be encouraged at the earliest age possible and be continued into early adulthood to optimize skeletal benefits.

Carvacrol attenuates N-nitrosodiethylamine induced liver injury in experimental Wistar rats

Directory of Open Access Journals (Sweden)

Balan Rajan

2015-06-01

Full Text Available Carvacrol is a main constituent in the essential oils of countless aromatic plants including Origanum Vulgare and Thymus vulgari, which has been assessed for substantial pharmacological properties. In recent years, notable research has been embarked on to establish the biological actions of Carvacrol for its promising use in clinical applications. The present study is an attempt to reveal the protective role of Carvacrol against N-Nitrosodiethylamine (DEN induced hepatic injury in male Wistar albino rats. DEN is an egregious toxin, present in numerous environmental factors, which enhances chemical driven liver damage by inducing oxidative stress and cellular injury. Administration of DEN (200 mg/kg bodyweight, I.P to rats results in elevated marker enzymes (in both serum and tissue. Carvacrol (15 mg/kg body weight suppressed the elevation of marker enzymes (in both serum and tissue and augmented the antioxidants levels. The hoisted activities of Phase I enzymes and inferior activities of Phase II enzymes were observed in DEN-administered animals, whereas Carvacrol treated animals showed improved near normal activity. Histological observations also support the protective role of Carvacrol against DEN induced liver damage. Final outcome from our findings intimate that Carvacrol might be beneficial in attenuating toxin induced liver damage.

Prevention of acute/severe hypoglycemia-induced neuron death by lactate administration.

Science.gov (United States)

Won, Seok Joon; Jang, Bong Geom; Yoo, Byung Hoon; Sohn, Min; Lee, Min Woo; Choi, Bo Young; Kim, Jin Hee; Song, Hong Ki; Suh, Sang Won

2012-06-01

Hypoglycemia-induced cerebral neuropathy can occur in patients with diabetes who attempt tight control of blood glucose and may lead to cognitive dysfunction. Accumulating evidence from animal models suggests that hypoglycemia-induced neuronal death is not a simple result of glucose deprivation, but is instead the end result of a multifactorial process. In particular, the excessive activation of poly (ADP-ribose) polymerase-1 (PARP-1) consumes cytosolic nicotinamide adenine dinucleotide (NAD(+)), resulting in energy failure. In this study, we investigate whether lactate administration in the absence of cytosolic NAD(+) affords neuroprotection against hypoglycemia-induced neuronal death. Intraperitoneal injection of sodium L-lactate corrected arterial blood pH and blood lactate concentration after hypoglycemia. Lactate administered without glucose was not sufficient to promote electroencephalogram recovery from an isoelectric state during hypoglycemia. However, supplementation of glucose with lactate reduced neuronal death by ∼80% in the hippocampus. Hypoglycemia-induced superoxide production and microglia activation was also substantially reduced by administration of lactate. Taken together, these results suggest an intriguing possibility: that increasing brain lactate following hypoglycemia offsets the decrease in NAD(+) due to overactivation of PARP-1 by acting as an alternative energy substrate that can effectively bypass glycolysis and be fed directly to the citric acid cycle to maintain cellular ATP levels.

From Lampedusa to Hamburg

DEFF Research Database (Denmark)

Meret, Susi; Jørgensen, Martin Bak

2014-01-01

As European countries throw up their walls and clamp down on refugees and migrants, the latter are increasingly responding with peaceful resistance.......As European countries throw up their walls and clamp down on refugees and migrants, the latter are increasingly responding with peaceful resistance....

Collision-induced polarizabilities of inert gas atoms

International Nuclear Information System (INIS)

Clarke, K.L.; Madden, P.A.; Buckingham, A.D.

1978-01-01

The use of polarizability densities to calculate collision-induced polarizabilities is investigated. One method for computing polarizabilities of inert gas diatoms employs atomic polarizability densities from finite-field Hartree-Fock calculations, together with classical equations for the polarization of dielectrics. It is shown that this model gives inaccurate values for both the local fields and the local response to non-uniform fields. An alternative method incorporating the same physical effects is used to compute the pair polarizabilities to first order in the interatomic interaction. To first order the pair contribution to the trace of the polarizability is negative at short range. The calculated anisotropy does not differ significantly from the DID value, whereas the polarizability density calculation gives a substantial reduction in the anisotropy. (author)

The association between substantiated childhood maltreatment, asthma and lung function: A prospective investigation.

Science.gov (United States)

Abajobir, Amanuel Alemu; Kisely, Steve; Williams, Gail; Strathearn, Lane; Suresh, Sadasivam; Najman, Jake Moses

2017-10-01

Asthma reflects multiple and likely complex causal pathways. We investigate the possibility that childhood maltreatment is one such causal pathway. Childhood maltreatment can be interpreted as a form of early life adversity and like other life adversities may predict a range of negative health outcomes, including asthma. A total of 3762 young adults (52.63% female) from the Mater Hospital-University of Queensland Study of Pregnancy (MUSP) participated in this study. MUSP is a prospective Australian birth cohort study of mothers consecutively recruited during their first antenatal clinic visit at Brisbane's Mater Hospital from 1981 to 1983. The study followed both mother-child dyads to the age of 21years after birth. Participants reported whether they had been diagnosed by a physician with asthma by the 21-year follow-up. Trained research assistants also performed gender- and height-standardized lung function tests using a Spirobank G spirometer system attached to a laptop computer. We linked this dataset with data obtained from the child protection services and which comprised all substantiated cases of childhood maltreatment in the MUSP cohort. Substantiations of childhood maltreatment included children in an age range of 0-14years. The experience of any childhood maltreatment, particularly emotional abuse, was independently associated with self-reported physician-diagnosed asthma by the 21-year follow-up. The association was no longer significant after adjustment for a range of confounders and covariates in neglected children. Childhood maltreatment, including multiple events, was not associated with lung function in adjusted models. Childhood maltreatment, including emotional abuse, was associated with lifetime ever asthma. This was in contrast to the absence of an association with objective measures of lung function. More research is indicated on the effect of childhood maltreatment on lung function using objective measures. In the meantime, there should be a

21 CFR 740.10 - Labeling of cosmetic products for which adequate substantiation of safety has not been obtained.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Labeling of cosmetic products for which adequate..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) COSMETICS COSMETIC PRODUCT WARNING STATEMENTS Warning Statements § 740.10 Labeling of cosmetic products for which adequate substantiation of safety has not been...

Results of induced atmosphere measurements from the Apollo program. [possible effects of the induced environment in the vicinity of manned spacecraft on future manned laboratory experiments

Science.gov (United States)

Naumann, R. J.

1974-01-01

Experiments on Apollo missions 15, 16, and 17 were utilized in an attempt to learn about the induced environment in the vicinity of manned spacecraft. Photographic sequences were examined to obtain scattered light data from the spacecraft-generated particulates during quiescence periods and after liquid dumps. The results allowed estimates of the obscuration factor and the clearing times after dumps. It was found that the clearing times were substantially longer than anticipated. The mass spectrometer detected a high molecular flux in lunar orbit which was induced by the spacecraft. It is shown that this is most likely caused by small ice crystals being continually produced in lunar orbit. Other data from the ultraviolet spectrometer and the stellar camera are also analyzed, and estimated values or upper limits are placed on the total scattering background, the size and number of particles generated, the velocity range, and the column density.

Large rainfall changes consistently projected over substantial areas of tropical land

Science.gov (United States)

Chadwick, Robin; Good, Peter; Martin, Gill; Rowell, David P.

2016-02-01

Many tropical countries are exceptionally vulnerable to changes in rainfall patterns, with floods or droughts often severely affecting human life and health, food and water supplies, ecosystems and infrastructure. There is widespread disagreement among climate model projections of how and where rainfall will change over tropical land at the regional scales relevant to impacts, with different models predicting the position of current tropical wet and dry regions to shift in different ways. Here we show that despite uncertainty in the location of future rainfall shifts, climate models consistently project that large rainfall changes will occur for a considerable proportion of tropical land over the twenty-first century. The area of semi-arid land affected by large changes under a higher emissions scenario is likely to be greater than during even the most extreme regional wet or dry periods of the twentieth century, such as the Sahel drought of the late 1960s to 1990s. Substantial changes are projected to occur by mid-century--earlier than previously expected--and to intensify in line with global temperature rise. Therefore, current climate projections contain quantitative, decision-relevant information on future regional rainfall changes, particularly with regard to climate change mitigation policy.

Monitoring failure rates of commercial implant brands; substantial equivalence in question?

Science.gov (United States)

Hujoel, Philippe; Becker, William; Becker, Burton

2013-07-01

The aim of this study was to report on the failure rates of two distinct dental implant systems in a clinical practice setting. Date of implant placement and loss were entered prospectively in a data registry system. Failure rates of two commercially pure titanium implants, one with a porous oxydized surface (POS) and the other with a chemically altered surface (CAS), were assessed using a quality control chart and survival analyses. A total of 860 POS and 759 CAS implants were placed. A warning of an increased failure rate of the CAS implant was identified by means of the quality control chart. Survival analyses indicated that the CAS implant failure rate was twice that of the POS implant (Hazard Ratio: 2.08; 95% CI: 1.33-3.28, P-value POS implant was associated with a non-significant 64% drop in the implant failure rate within less than a year (HR: 0.36; 95% CI: 0.12-1.14; P-value POS implant and an 8% failure with the CAS implant appears inconsistent with the assumption of substantial equivalence. © 2012 John Wiley & Sons A/S.

Smoke-induced seed germination in California chaparral

Science.gov (United States)

Keeley, J.E.; Fotheringham, C.J.

1998-01-01

smoke. While the mechanism behind smoke-induced germination is not known, it appears that smoke may be involved in overcoming different blocks to germination in different species. For example, in Emmenanthe penduliflora, NO2 in smoke was sufficient to induce germination, and most forms of physical or chemical scarification also induced germination. For Romneya coulteri, NO2 alone failed to induce germination, and scarified seeds required addition of gibberellic acid. In Dicentra chrysantha, none of these treatments, nor smoke alone, induced germination, but germination was triggered by a combination of soil burial followed by smoke treatment. Smoke-stimulated species differed substantially in the duration of smoke exposure required to induce germination, and this was inversely correlated with tolerance to smoke exposure. We suggest that such differences in response may affect postfire community structure.

Experimental study of ion-induced nucleation by radon decay

International Nuclear Information System (INIS)

He, F.; Hopke, P.K.

1993-01-01

In the environment, the presence of ions from natural radioactivity may increase the rate of new particle formation through ion-induced nucleation. A thermal diffusion cloud chamber (TDCC) has been built to experimentally study ion-induced nucleation where the ions are produced by gaseous radioactive sources. The critical supersaturation values and nucleation rates for methanol, ethanol, 1-propanol, and 1-butanol vapors on ions produced within the volume of the chamber by alpha decay of 222 Rn have been measured quantitatively at various radioactivity concentrations and supersaturations. The presence of ion tracks and the effect of an external electric field were also investigated. The alpha tracks and ion-induced nucleation formed by 222 Rn decay become visible at the critical supersaturation that is below the value needed for homogeneous nucleation. At this supersaturation, the nucleation rates increase substantially with increasing 222 Rn at low activity concentrations, but attain limiting values at higher concentrations. The experimental results indicate that the ionization by radon decay will promote ion-cluster formation and lower the free energy barriers. The formation of visible droplets is strongly dependent on the supersaturation. This study also confirms that the external electric field has a significant effect on the observed rates of nucleation

26 CFR 301.6621-2T - Questions and answers relating to the increased rate of interest on substantial underpayments...

Science.gov (United States)

2010-04-01

...) the expenditure was prepaid for tax avoidance purposes and not for a business purpose, or (iii) the... rate of interest on substantial underpayments attributable to certain tax motivated transactions... underpayments attributable to certain tax motivated transactions (temporary). The following questions and...

Hotel services for hypotonics in Ukraine: scientific-practical results of eco-nomic-organizational and marketing substantiation

Directory of Open Access Journals (Sweden)

Pereyaslova Yuliya

2015-10-01

Full Text Available The article is dedicated to economic-organizational and marketing substantiation of the newest for Ukraine hotel service for patients with hypotension. The necessity of proposition of the market of such services is an extremely actual direction not only in hotel economy but in medical service of the country’s population today. It confirms the social targeting of the hotel service offer at the existent market, responsibility before the society and the future competitiveness of such hotel.

Integrating fundamental movement skills in late childhood.

Science.gov (United States)

Gimenez, Roberto; Manoel, Edison de J; de Oliveira, Dalton Lustosa; Dantas, Luiz; Marques, Inara

2012-04-01

The study examined how children of different ages integrate fundamental movement skills, such as running and throwing, and whether their developmental status was related to the combination of these skills. Thirty children were divided into three groups (G1 = 6-year-olds, G2 = 9-year-olds, and G3 = 12-year-olds) and filmed performing three tasks: running, overarm throwing, and the combined task. Patterns were identified and described, and the efficiency of integration was calculated (distance differences of the ball thrown in two tasks, overarm throwing and combined task). Differences in integration were related to age: the 6-year-olds were less efficient in combining the two skills than the 9- and 12-year-olds. These differences may be indicative of a phase of integrating fundamental movement skills in the developmental sequence. This developmental status, particularly throwing, seems to be related to the competence to integrate skills, which suggests that fundamental movement skills may be developmental modules.

Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex

Directory of Open Access Journals (Sweden)

Christophe Heinrich

2014-12-01

Full Text Available The adult cerebral cortex lacks the capacity to replace degenerated neurons following traumatic injury. Conversion of nonneuronal cells into induced neurons has been proposed as an innovative strategy toward brain repair. Here, we show that retrovirus-mediated expression of the transcription factors Sox2 and Ascl1, but strikingly also Sox2 alone, can induce the conversion of genetically fate-mapped NG2 glia into induced doublecortin (DCX+ neurons in the adult mouse cerebral cortex following stab wound injury in vivo. In contrast, lentiviral expression of Sox2 in the unlesioned cortex failed to convert oligodendroglial and astroglial cells into DCX+ cells. Neurons induced following injury mature morphologically and some acquire NeuN while losing DCX. Patch-clamp recording of slices containing Sox2- and/or Ascl1-transduced cells revealed that a substantial fraction of these cells receive synaptic inputs from neurons neighboring the injury site. Thus, NG2 glia represent a potential target for reprogramming strategies toward cortical repair.

Study on DNA Damage Induced by Neon Beam Irradiation in Saccharomyces Cerevisiae

International Nuclear Information System (INIS)

Lu Dong; Li Wenjian; Wu Xin; Wang Jufang; Ma Shuang; Liu Qingfang; He Jinyu; Jing Xigang; Ding Nan; Dai Zhongying; Zhou Jianping

2010-01-01

Yeast strain Saccharomyces cerevisiae was irradiated with different doses of 85 MeV/u 20 Ne 10+ to investigate DNA damage induced by heavy ion beam in eukaryotic microorganism. The survival rate, DNA double strand breaks (DSBs) and DNA polymorphic were tested after irradiation. The results showed that there were substantial differences in DNA between the control and irradiated samples. At the dose of 40 Gy, the yeast cell survival rate approached 50%, DNA double-strand breaks were barely detectable, and significant DNA polymorphism was observed. The alcohol dehydrogenase II gene was amplified and sequenced. It was observed that base changes in the mutant were mainly transversions of T→G and T→C. It can be concluded that heavy ion beam irradiation can lead to change in single gene and may be an effective way to induce mutation.

Study on DNA Damage Induced by Neon Beam Irradiation in Saccharomyces Cerevisiae

Science.gov (United States)

Lu, Dong; Li, Wenjian; Wu, Xin; Wang, Jufang; Ma, Shuang; Liu, Qingfang; He, Jinyu; Jing, Xigang; Ding, Nan; Dai, Zhongying; Zhou, Jianping

2010-12-01

Yeast strain Saccharomyces cerevisiae was irradiated with different doses of 85 MeV/u 20Ne10+ to investigate DNA damage induced by heavy ion beam in eukaryotic microorganism. The survival rate, DNA double strand breaks (DSBs) and DNA polymorphic were tested after irradiation. The results showed that there were substantial differences in DNA between the control and irradiated samples. At the dose of 40 Gy, the yeast cell survival rate approached 50%, DNA double-strand breaks were barely detectable, and significant DNA polymorphism was observed. The alcohol dehydrogenase II gene was amplified and sequenced. It was observed that base changes in the mutant were mainly transversions of T→G and T→C. It can be concluded that heavy ion beam irradiation can lead to change in single gene and may be an effective way to induce mutation.

Chemotherapy-induced peripheral neuropathy in patients treated with taxanes and platinum derivatives

DEFF Research Database (Denmark)

Ewertz, Marianne; Qvortrup, Camilla; Eckhoff, Lise

2015-01-01

BACKGROUND: Chemotherapy with taxanes and platinum compounds has resulted in substantial survival benefits both in adjuvant and metastatic settings. However, as a side effect, such chemotherapy may cause peripheral neuropathy (CIPN) which may result in discontinuation of treatment...... or shortly after the infusion triggered by exposure to cold. Risks factors for CIPN include preexisting neuropathy, either from treatment with other neurotoxic agents, or from comorbid conditions. The incidence of CIPN is related to dose per cycle, cumulative dose, and duration of infusion. While cisplatin......-induced neuropathy is irreversible, CIPN induced by taxanes may persist for several years in about 30% of patients. Evidence from the literature is suggestive that CIPN is likely to be negatively associated with QoL. No agents have been identified to be recommended for the prevention of CIPN. For treatment of CIPN...

Taking aim at Müller-Lyer goalkeeper illusion: An illusion bias in action that originates from the target not being optically specified.

NARCIS (Netherlands)

Shim, J.; van der Kamp, J.; Rigby, B.R.; Lutz, R.; Poolton, J.M.; Masters, R.S.W.

2014-01-01

Van der Kamp and Masters (2008) reported that goalkeeper postures that mimic the Müller-Lyer (1889) illusion affect the location of handball penalty throws. In four experiments, we aimed to verify that the effects on throwing are consistent with an illusorybias(Experiments 1 and 2), and to examine

WWER-440 reactor thermal power increase. Up-to-date approaches to substantiation of the core heat-engineering reliability

International Nuclear Information System (INIS)

Vasilchenko, I.; Lushin, V.; Zubtsov, D.

2006-01-01

Increasing the Units power is an urgent problem for nuclear power plants with WWER-440 reactors. Improving the fuel assembly designs and calculated codes creates all prerequisites to fulfil this purpose. The decrease in the core power peaking is reached by using the profiled fuel assemblies, burnable absorber integrated into the fuel, the FA with the modernized interface attachment, modern calculated codes that allows to reduce conservatism of the RP safety substantiation. A wide spectrum of experimental study of behaviour of the fuel having reached burn-up (50-60) MW days / kg U under the transients and accident conditions was carried out, the post-irradiated examination of the fuel assemblies, fuel rods and fuel pellets with four and five annual operating fuel cycle were performed as well and confirmed the high reliability of the fuel, the presence of large margins of the fuel stack state that contributes to reactor operation at the increased power. The results of the carried out experiments on implementing the five and six annual fuel cycles show that the limiting fuel state as to its serviceability in the WWER-440 reactors is far from being reached. Presently there is an experience of the increased power operation of Kola NPP, Units 1, 2, 4 and Rovno NPP, Unit 2. The Loviisa NPP Units are operated at 109 % power. The Russian experts had gained an experience in substantiating the core operation at 108 % power for Paks NPP, Unit 4. In this paper the additional conditions for increasing the power of the Kola NPP, Units 1 and 2 and the main results of substantiation of increase in power of the Paks NPP, Unit 4 up to 1485 MW are presented in details

Challenges in Archiving and Sharing Video Data: Considering Moral, Pragmatic, and Substantial Arguments

Directory of Open Access Journals (Sweden)

Terhi Kirsi Korkiakangas

2014-05-01

Full Text Available Social science researchers are facing new challenges in data archiving and sharing. The challenges encountered for video data are different from those encountered for other types of qualitative data. I will consider these challenges with respect to the moral, pragmatic, and substantial arguments with which funding bodies justify data archiving and sharing. Throughout the article, I will draw on a recent Economic and Social Research Council funded project, “Transient Teams in the Operating Theatre,” in which our research team video recorded work activities in the operating theatre of a UK hospital, thereby dealing with highly sensitive footage. I will consider how video data, on most occasions, cannot be archived for re-use by the wider research community, but how new avenues could be developed so as to benefit from further research on such “unarchivable” datasets.

Separate and Combined Effects of Caffeine and Sodium-Bicarbonate Intake on Judo Performance.

Science.gov (United States)

Felippe, Leandro C; Lopes-Silva, João P; Bertuzzi, Rômulo; McGinley, Cian; Lima-Silva, Adriano E

2016-03-01

The combined supplementation of caffeine (CAF) and sodium bicarbonate (NaHCO3) may have a potential ergogenic effect during intermittent-exercise tasks such as judo; however, its effect in this sport has not been tested. To investigate the isolated and combined effects of CAF and NaHCO3 on judo performance. Ten judokas performed 4 supplementation protocols-NaHCO3, CAF, NaHCO3 + CAF, and placebo (PLA) (cellulose)-followed by 3 Special Judo Fitness Tests (SJFTs) interspaced with 5 min rest. In the first SJFT, the combined supplement (NaHCO3 + CAF) resulted in a higher number of throws than with PLA (24.4 ± 0.9 and 23.2 ± 1.5 throws, respectively, P = .02). There was no significant difference between conditions for the 2nd SJFT (P = .11). In the 3rd SJFT, NaHCO3 and NaHCO3 + CAF resulted in more throws than with PLA (23.7 ± 1.6, 24.4 ± 1.0, and 22.0 ± 1.6 throws, P = .001 and P = .03, respectively). When the total throws performed in the 3 SJFTs were summed, they were higher than PLA only for NaHCO3 + CAF (68.8 ± 4.4 and 72.7 ± 3.1 throws, respectively, P = .003). Postexercise plasma lactate after each SJFT was higher in all experimental conditions than with PLA (P = .001). There was no significant difference in rating of perceived exertion across the conditions (P = .18). The results of the current study show that the combined supplementation of NaHCO3 + CAF increases judo performance compared with PLA.

Grammatical Conception of Yuriy Shevel'ov: Nominative ↔ Vocative in the System of Substantial Categoriality

Directory of Open Access Journals (Sweden)

Anatoliy Zahnitko

2016-08-01

Full Text Available Background. Analysis of Yuriy Shevel'ov’s approaches to the interpretation of the morphological tier of language, as well as his examination of particular phenomena of this level – substantiality, verbality, and others – reflects not only the author's understanding itself of all the grammatical system as a whole, and morphological one in particular, but also represents the features of modification of scientific approaches in the history of linguistic thought of mid-twentieth century, its strengthening in the studies of the XX – XXI century. The researcher’s definition of nominative and vocative cases as interrelated within the categorical substantiality is of particular importance. Purpose: to determine the main components of interpretation of the status dimension of the nominative and vocative cases within morpho-substantial categoriality of Yuriy Shevel'ov with the definition of theoretical foundations and practical principles, revealing the patterns of establishing internal sentence dimension of the nominative and vocative cases. Results: In the case theory with reliance on the sequence of forms of dependencies in the internal sentence space Yuriy Shevel'ov distinguishes five cases: genitive, dative, accusative, ablative, locative. In the statement about the nominative as grammatically independent case the scientist relies on sentence. Two-dimensionality of grammatically independent case opposes to the one-dimensional grammatically dependent nominative that is traceable in syntactic positions of predicate and apposition. Yuriy Shevel'ov did not consider addressing that is not grammatically linked to the sentence with a specific expression as an individual case. The forms of vocative case show functional three-componentity, because in its functional-semantic paradigm it covers the function of the addressee – potential subject of action (primary function that is represented in formal grammar sentence structure by the main element of

Gut-Sourced Vasoactive Intestinal Polypeptide Induced by the Activation of α7 Nicotinic Acetylcholine Receptor Substantially Contributes to the Anti-inflammatory Effect of Sinomenine in Collagen-Induced Arthritis

Directory of Open Access Journals (Sweden)

MengFan Yue

2018-06-01

Full Text Available Sinomenine has long been used for the treatment of rheumatoid arthritis in China. However, its anti-inflammatory mechanism is still debatable because the in vitro minimal effective concentration (≥250 μM is hardly reached in either synovium or serum after oral administration at a therapeutic dose. Recent findings suggest that the α7 nicotinic acetylcholine receptor (α7nAChR might mediate the inhibitory effect of sinomenine on macrophage activation, which attracts us to explore the anti-arthritis mechanism of sinomenine by taking neuroendocrine-inflammation axis into consideration. Here, we showed that orally administered sinomenine ameliorated the systemic inflammation of collagen-induced arthritis (CIA rats, which was significantly diminished by either vagotomy or the antagonists of nicotinic acetylcholine receptors (especially the antagonist of α7nAChR, but not by the antagonists of muscarinic receptor. Sinomenine might bind to α7nAChR through interacting with the residues Tyr184 and Tyr191 in the pocket. In addition, the generation of vasoactive intestinal polypeptide (VIP from the gut of CIA rats and cultured neuron-like cells was selectively enhanced by sinomenine through the activation of α7nAChR-PI3K/Akt/mTOR pathway. The elevated levels of VIP in the serum and small intestine of rats were negatively correlated with the scores of joint destruction. The crucial role of VIP in the anti-arthritic effect of sinomenine was confirmed by using VIP hybrid, a non-specific antagonist of VIP receptor. Taken together, intestine-sourced VIP mediates the anti-arthritic effect of sinomenine, which is generated by the activation of α7nAChR.

Evolving paradigms in the treatment of opioid-induced bowel dysfunction.

Science.gov (United States)

Poulsen, Jakob Lykke; Brock, Christina; Olesen, Anne Estrup; Nilsson, Matias; Drewes, Asbjørn Mohr

2015-11-01

In recent years prescription of opioids has increased significantly. Although effective in pain management, bothersome gastrointestinal adverse effects are experienced by a substantial proportion of opioid-treated patients. This can lead to difficulties with therapy and subsequently inadequate pain relief. Collectively referred to as opioid-induced bowel dysfunction, these adverse effects are the result of binding of exogenous opioids to opioid receptors in the gastrointestinal tract. This leads to disturbance of three important gastrointestinal functions: motility, coordination of sphincter function and secretion. In the clinic this manifests in a wide range of symptoms such as reflux, bloating, abdominal cramping, hard, dry stools, and incomplete evacuation, although the most known adverse effect is opioid-induced constipation. Traditional treatment with laxatives is often insufficient, but in recent years a number of novel pharmacological approaches have been introduced. In this review the pathophysiology, symptomatology and prevalence of opioid-induced bowel dysfunction is presented along with the benefits and caveats of a suggested consensus definition for opioid-induced constipation. Finally, traditional treatment is appraised and compared with the latest pharmacological developments. In conclusion, opioid antagonists restricted to the periphery show promising results, but use of different definitions and outcome measures complicate comparison. However, an international working group has recently suggested a consensus definition for opioid-induced constipation and relevant outcome measures have also been proposed. If investigators within this field adapt the suggested consensus and include symptoms related to dysfunction of the upper gut, it will ease comparison and be a step forward in future research.

Irradiation strongly reduces tumorigenesis of human induced pluripotent stem cells

International Nuclear Information System (INIS)

Inui, Shoki; Minami, Kazumasa; Ito, Emiko; Imaizumi, Hiromasa; Mori, Seiji; Koizumi, Masahiko; Fukushima, Satsuki; Miyagawa, Shigeru; Sawa, Yoshiki; Matsuura, Nariaki

2017-01-01

Induced pluripotent stem (iPS) cells have demonstrated they can undergo self-renewal, attain pluripotency, and differentiate into various types of functional cells. In clinical transplantation of iPS cells, however, a major problem is the prevention of tumorigenesis. We speculated that tumor formation could be inhibited by means of irradiation. Since the main purpose of this study was to explore the prevention of tumor formation in human iPS (hiPS) cells, we tested the effects of irradiation on tumor-associated factors such as radiosensitivity, pluripotency and cell death in hiPS cells. The irradiated hiPS cells showed much higher radiosensitivity, because the survival fraction of hiPS cells irradiated with 2 Gy was < 10%, and there was no change of pluripotency. Irradiation with 2 and 4 Gy caused substantial cell death, which was mostly the result of apoptosis. Irradiation with 2 Gy was detrimental enough to cause loss of proliferation capability and trigger substantial cell death in vitro. The hiPS cells irradiated with 2 Gy were injected into NOG mice (NOD/Shi-scid, IL-2 Rγnull) for the analysis of tumor formation. The group of mice into which hiPS cells irradiated with 2 Gy was transplanted showed significant suppression of tumor formation in comparison with that of the group into which non-irradiated hiPS cells were transplanted. It can be presumed that this diminished rate of tumor formation was due to loss of proliferation and cell death caused by irradiation. Our findings suggest that tumor formation following cell therapy or organ transplantation induced by hiPS cells may be prevented by irradiation.

Room-Temperature Spin-Orbit Torque Switching Induced by a Topological Insulator

Science.gov (United States)

Han, Jiahao; Richardella, A.; Siddiqui, Saima A.; Finley, Joseph; Samarth, N.; Liu, Luqiao

2017-08-01

The strongly spin-momentum coupled electronic states in topological insulators (TI) have been extensively pursued to realize efficient magnetic switching. However, previous studies show a large discrepancy of the charge-spin conversion efficiency. Moreover, current-induced magnetic switching with TI can only be observed at cryogenic temperatures. We report spin-orbit torque switching in a TI-ferrimagnet heterostructure with perpendicular magnetic anisotropy at room temperature. The obtained effective spin Hall angle of TI is substantially larger than the previously studied heavy metals. Our results demonstrate robust charge-spin conversion in TI and provide a direct avenue towards applicable TI-based spintronic devices.

Opposite variations in maternal and neonatal thyroid function induced by iodine supplementation during pregnancy

DEFF Research Database (Denmark)

Nøhr, S B; Laurberg, P

2000-01-01

pregnancy, and 95 took no artificial iodine supplementation. Iodine supplementation (+I) induced opposite variations in thyroid function in the mother and the fetus. In +I mothers, TSH was 7.6% lower than in mothers with no supplementation (P ... in the +I group (P caused by opposite shifts in TSH frequency distribution in mothers and neonates. The association between iodine supplementation and high serum TSH in the neonates was further substantiated by an inverse correlation between thyroglobulin and TSH in cord blood...

That’s Not What I Joined to Do, Sir -- Understanding Military Culture and Ethos is Critical for the Correct Use of the Military Instrument of Power

Science.gov (United States)

2012-05-21

took over a decade and was ―like trying to stop a tank by throwing marshmallows at it. The military, like any huge bureaucracy, resists innovation...leadership, will be like ―throwing marshmallows against a tank.‖ The latter requires a re-evaluation by political leaders of the part the military

The Association between Motor Skill Competence and Physical Fitness in Young Adults

Science.gov (United States)

Stodden, David; Langendorfer, Stephen; Roberton, Mary Ann

2009-01-01

We examined the relationship between competence in three fundamental motor skills (throwing, kicking, and jumping) and six measures of health-related physical fitness in young adults (ages 18-25). We assessed motor skill competence using product scores of maximum kicking and throwing speed and maximum jumping distance. A factor analysis indicated…

Influence of ballistic bench press on upper body power output in professional rugby players.

Science.gov (United States)

West, Daniel J; Cunningham, Daniel J; Crewther, Blair T; Cook, Christian J; Kilduff, Liam P

2013-08-01

The use of heavy resistance exercise provides an effective preload stimulus for inducing postactivation potentiation (PAP) and increasing peak power output (PPO). However, this approach has limited application in many sporting situations (e.g., incorporation in a precompetition warm-up); and therefore, more practical strategies for inducing PAP need to be investigated. The aim of the present study was to compare the PPO changes after performing a preload stimulus of either a ballistic exercise or a traditional heavy resistance exercise. Twenty professional rugby union players completed 3 testing sessions, each separated by 48 hours. On the first occasion, subjects underwent a 3 repetition maximum (3RM)-bench press testing session. On the next 2 occasions, subjects performed a ballistic bench throw at baseline (30% of 1RM), followed by a preload stimulus of either heavy resistance training (HRT) (heavy bench press: 3 sets of 3 repetitions at 87% 1RM) or BBP (3 sets of 3 repetitions at 30% on 1RM) followed by ballistic bench throw after 8 minutes recovery. The trials were randomized and counterbalanced. Both preload stimuli protocols increased PPO compared with baseline (BBP baseline 892 ± 108 vs. 8 minutes 924 ± 119 W, p < 0.001; HRT baseline 893 ± 104 vs. 8 minutes 931 ± 116 W; p < 0.001). There were no conditional differences between PPO at 8 minutes (p = 0.141); moreover, the change in PPO from baseline was also similar between conditions (BBP Δ + 33 ± 18; HRT Δ + 38 ± 21 W; p = 0.112). In conclusion, a ballistic exercise provided an effective method of inducing PAP and increasing upper-body PPO; moreover, this elicited similar increases in PPO as a traditional heavy resistance exercise preloading stimulus.

EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the substantiation of a health claim related to high-fibre sourdough rye bread and reduction of post-prandial glycaemic responses pursuant to Article 13(5) of Regulation (EC) No 1924/2006

DEFF Research Database (Denmark)

Tetens, Inge

responses when compared with glucose. The Panel also notes that, when comparable amounts of available carbohydrates from different carbohydrate-containing foods are tested, almost any carbohydrate-containing food would induce a reduction of post-prandial blood glucose responses compared with glucose....... In addition, foods containing low amounts of, or no available carbohydrates, will also induce lower post-prandial blood glucose responses when compared with glucose. The Panel concludes that a cause and effect relationship has been established between the consumption of almost any food and a reduction of post...... on the scientific substantiation of a health claim related to high‑fibre sourdough rye bread and a reduction of post-prandial glycaemic responses. The Panel considers that the food, high-fibre sourdough rye bread, and its “comparator”, glucose, are sufficiently characterised in relation to the claimed effect...

Unconventional resource's production under desorption-induced effects

Directory of Open Access Journals (Sweden)

S. Sina Hosseini Boosari

2016-06-01

We have developed a numerical model to study the effect of changes in porosity, permeability and compaction on four major U.S. shale formations considering their Langmuir isotherm desorption behavior. These resources include; Marcellus, New Albany, Barnett and Haynesville Shales. First, we introduced a model that is a physical transport of single-phase gas flow in shale porous rock. Later, the governing equations are implemented into a one-dimensional numerical model and solved using a fully implicit solution method. It is found that the natural gas production is substantially affected by desorption-induced porosity/permeability changes and geomechancis. This paper provides valuable insights into accurate modeling of unconventional reservoirs that is more significant when an even small correction to the future production prediction can enormously contribute to the U.S. economy.

Wisdom, Uncertainty, and Ambiguity in Management Decisions Based on Experiences and the Trustworthiness of Research Methods to Substantiate Them

Directory of Open Access Journals (Sweden)

Ronald Jean Degen

2017-12-01

Full Text Available Wisdom, uncertainty, and ambiguity will always exist in management decisions. One danger for firms lies in managers making decisions based on faulty theories acquired through personal experiences or learned from the experiences of others. Often, these decisions don’t generate the expected outcome and may even put the future of the firm at risk. Managers, to avoid this risk, are required to become wiser, more discerning, and more appropriately skeptical toward personal theories or theories learned from management gurus that propose simplistic formulas and quick-fix remedies. In this paper, the author discusses the risk of decisions based on personal theories or theories learned from others, the business research methods used to substantiate these theories, the philosophical assumptions of business research, the strength and weaknesses of qualitative and quantitative research methods, the benefits of combining both methods, and the trustworthiness of research methods in general for substantiating the theories used by managers in their decision-making.