WorldWideScience

Sample records for thousand year history

  1. How does one do the history of disability in antiquity? One thousand years of case studies.

    Science.gov (United States)

    Laes, Christian

    2011-01-01

    Exploring literary sources from the first century BCE up to the eleventh century CE, this article demonstrates how the history of disabilities in antiquity can go further than just collecting 'interesting case histories'. Using a model developed by Michel Vovelle, the sources are interpreted on different levels, taking into account both the cultural context in which the text arose and the intentions of the author.

  2. "Lou soil", a fertile anthropogenic soil with thousands of years of cultivating history

    Science.gov (United States)

    Zhou, J.; Liang, B.; Yan, J.; Zhao, W.

    2012-12-01

    Chinese farmers have a very long history of using manures in their fields. Owing to the long-term addition of manures, an anthropogenic layer was formed on the top of original soil profile (drab soil) in Guanzhong Plains on the south edge of the Loess Plateau, North China. This soil is named the Manural Loessial soil (or Lou soil, "Lou" means the different stories of a building in Chinese). The depth of anthropogenic layer is in range of about 30 to 100 cm depth, which has a close relationship with the soil productivity. This fertile agricultural soil has sustained the agriculture in the region for millenniums. We had determined the organic carbon (SOC) in 7 soil profiles, and found that the depths of anthropogenic layer of were in range of 40 to 71 cm (averaging 59 cm). And the anthropogenic layer became shallower as the profile was far from the village due to less manure application. The organic C stocks in this layer accounted for 69% of organic C stocks in 0-100 cm soil profiles. Organic C stocks in Lou soil was higher than that in the newly cultivated soil developed from loess parent materials. Our 30-day incubation experiment found that addition of synthetic N fertilizer significantly increased the decomposition of SOC in the soils. However, The decomposition rate of SOC in the soil added with manure and inorganic fertilizers for 18-yr (MNPK soil) was significantly lower than in the soils added without fertilizer or inorganic fertilizers (NF soil, and NPK soils). The half-life of the organic C in MNPK soils was also slower than the NF soil, and NPK soil. It indicates that long-term combined application of manure and inorganic fertilizers improves the stabilization of soil organic C. Long-term cultivation has not only increased organic C stocks, but also stabilization of organic C in soil profile. It provides us a unique sample to study the mechanism of accumulation and stabilization of organic C in soil to balance agricultural production and C sequestration

  3. Ten Thousand Years of Solitude?

    International Nuclear Information System (INIS)

    Benford, G.; Pasqualetti, M.J.

    1991-03-01

    This report documents the authors work as an expert team advising the US Department of Energy on modes of inadvertent intrusion over the next 10,000 years into the Waste Isolation Pilot Project (WIPP) nuclear waste repository. Credible types of potential future accidental intrusion into the WIPP are estimated as a basis for creating warning markers to prevent inadvertent intrusion. A six-step process is used to structure possible scenarios for such intrusion, and it is concluded that the probability of inadvertent intrusion into the WIPP repository over the next ten thousand years lies between one and twenty-five percent. 3 figs., 5 tabs

  4. Ten Thousand Years of Solitude

    Energy Technology Data Exchange (ETDEWEB)

    Benford, G. (Los Alamos National Lab., NM (USA) California Univ., Irvine, CA (USA). Dept. of Physics); Kirkwood, C.W. (Los Alamos National Lab., NM (USA) Arizona State Univ., Tempe, AZ (USA). Coll. of Business Administration); Harry, O. (Los Alamos National Lab., NM (USA)); Pasqualetti, M.J. (Los Alamos National Lab., NM (USA) Arizona State Univ., Tempe, AZ (USA))

    1991-03-01

    This report documents the authors work as an expert team advising the US Department of Energy on modes of inadvertent intrusion over the next 10,000 years into the Waste Isolation Pilot Project (WIPP) nuclear waste repository. Credible types of potential future accidental intrusion into the WIPP are estimated as a basis for creating warning markers to prevent inadvertent intrusion. A six-step process is used to structure possible scenarios for such intrusion, and it is concluded that the probability of inadvertent intrusion into the WIPP repository over the next ten thousand years lies between one and twenty-five percent. 3 figs., 5 tabs.

  5. The thousand-year history of the Slovak Karst inferred from pollen in bat guano inside the Domica Cave (Slovakia)

    Czech Academy of Sciences Publication Activity Database

    Svitavská-Svobodová, Helena; Andreas, M.; Krištůfek, Václav; Beneš, J.; Novák, J.

    2015-01-01

    Roč. 50, č. 1 (2015), s. 49-61 ISSN 1211-9520 R&D Projects: GA MŠk LC06066 Institutional support: RVO:67985939 ; RVO:60077344 Keywords : bat * pollen * guano Subject RIV: EF - Botanics; EF - Botanics (BC-A) Impact factor: 1.433, year: 2015

  6. Sixty thousand years of magmatic volatile history before the caldera-forming eruption of Mount Mazama, Crater Lake, Oregon

    Science.gov (United States)

    Wright, Heather Michelle; Bacon, Charles R.; Vazquez, Jorge A.; Sisson, Thomas W.

    2012-12-01

    The well-documented eruptive history of Mount Mazama, Oregon, provides an excellent opportunity to use pre-eruptive volatile concentrations to study the growth of an explosive silicic magmatic system. Melt inclusions (MI) hosted in pyroxene and plagioclase crystals from eight dacitic-rhyodacitic eruptive deposits (71-7.7 ka) were analyzed to determine variations in volatile-element concentrations and changes in magma storage conditions leading up to and including the climactic eruption of Crater Lake caldera. Temperatures (Fe-Ti oxides) increased through the series of dacites, then decreased, and increased again through the rhyodacites (918-968 to ~950 to 845-895 °C). Oxygen fugacity began at nickel-nickel-oxide buffer (NNO) +0.8 (71 ka), dropped slightly to NNO +0.3, and then climbed to its highest value with the climactic eruption (7.7 ka) at NNO +1.1 log units. In parallel with oxidation state, maximum MI sulfur concentrations were high early in the eruptive sequence (~500 ppm), decreased (to ~200 ppm), and then increased again with the climactic eruption (~500 ppm). Maximum MI sulfur correlates with the Sr content (as a proxy for LREE, Ba, Rb, P2O5) of recharge magmas, represented by basaltic andesitic to andesitic enclaves and similar-aged lavas. These results suggest that oxidized Sr-rich recharge magmas dominated early and late in the development of the pre-climactic dacite-rhyodacite system. Dissolved H2O concentrations in MI do not, however, correlate with these changes in dominant recharge magma, instead recording vapor solubility relations in the developing shallow magma storage and conduit region. Dissolved H2O concentrations form two populations through time: the first at 3-4.6 wt% (with a few extreme values up to 6.1 wt%) and the second at ≤2.4 wt%. CO2 concentrations measured in a subset of these inclusions reach up to 240 ppm in early-erupted deposits (71 ka) and are below detection in climactic deposits (7.7 ka). Combined H2O and CO2

  7. Durable Glass For Thousands Of Years

    International Nuclear Information System (INIS)

    Jantzen, C.

    2009-01-01

    The durability of natural glasses on geological time scales and ancient glasses for thousands of years is well documented. The necessity to predict the durability of high level nuclear waste (HLW) glasses on extended time scales has led to various thermodynamic and kinetic approaches. Advances in the measurement of medium range order (MRO) in glasses has led to the understanding that the molecular structure of a glass, and thus the glass composition, controls the glass durability by establishing the distribution of ion exchange sites, hydrolysis sites, and the access of water to those sites. During the early stages of glass dissolution, a 'gel' layer resembling a membrane forms through which ions exchange between the glass and the leachant. The hydrated gel layer exhibits acid/base properties which are manifested as the pH dependence of the thickness and nature of the gel layer. The gel layer ages into clay or zeolite minerals by Ostwald ripening. Zeolite mineral assemblages (higher pH and Al 3+ rich glasses) may cause the dissolution rate to increase which is undesirable for long-term performance of glass in the environment. Thermodynamic and structural approaches to the prediction of glass durability are compared versus Ostwald ripening.

  8. DURABLE GLASS FOR THOUSANDS OF YEARS

    Energy Technology Data Exchange (ETDEWEB)

    Jantzen, C.

    2009-12-04

    The durability of natural glasses on geological time scales and ancient glasses for thousands of years is well documented. The necessity to predict the durability of high level nuclear waste (HLW) glasses on extended time scales has led to various thermodynamic and kinetic approaches. Advances in the measurement of medium range order (MRO) in glasses has led to the understanding that the molecular structure of a glass, and thus the glass composition, controls the glass durability by establishing the distribution of ion exchange sites, hydrolysis sites, and the access of water to those sites. During the early stages of glass dissolution, a 'gel' layer resembling a membrane forms through which ions exchange between the glass and the leachant. The hydrated gel layer exhibits acid/base properties which are manifested as the pH dependence of the thickness and nature of the gel layer. The gel layer ages into clay or zeolite minerals by Ostwald ripening. Zeolite mineral assemblages (higher pH and Al{sup 3+} rich glasses) may cause the dissolution rate to increase which is undesirable for long-term performance of glass in the environment. Thermodynamic and structural approaches to the prediction of glass durability are compared versus Ostwald ripening.

  9. Doctors and baldness: a five thousand year old challenge.

    Science.gov (United States)

    Campo, Daniele; D'Acunzo, Valeria

    2016-02-01

    The history of trichology follows a thread that continually intersects with that of the history of medicine in general. Even Hippocrates believed that the approach to baldness should be of a medical nature. This confrontation between doctors and hair loss, which has lasted for five thousand years, begins with the invocations of the head physicians in the Egyptian era and ends with the recent institution of postgraduate Master's degrees at Faculties of Medicine and Surgery. The biggest names in medicine concerned themselves with trichology beginning with Hippocrates, who dealt with the topic in his most famous work: the Aphorisms. Even the most celebrated doctors of the Roman era, such as Galen and Pliny the Elder, did not disdain considering hair loss, leaving important scientific contributions before passing on the baton to their distinguished colleagues of the Byzantine Empire. The narrative then flows through the most prestigious institutions of the Middle Ages, such as the Salerno School of Medicine and the Siena Accademia del Fisiocritici where, at the end of the 1600s, the distinguished anatomical describer Marcello Malpighi also taught trichology, and left his contribution to "Hair Science" with a fine description of the hair follicle in the pages of his Opera Posthuma. At the turn of the late Middle Ages and the early modern era, barbers formed the primordial nucleus of surgery and at the same time became the ones to concern themselves with hair loss. In the 1800s, several doctors published the first texts dealing with the anatomy and physiology of the hair and taking into account the principal forms of alopecia, but at the therapeutic level did not yet propose anything scientifically valid. Until a few decades ago trichology still lent itself to various commercial speculations. It was not until the twentieth century that the pathogenetic mechanisms of baldness were clarified in a scientific manner. With this knowledge, the pharmaceutical industry has been

  10. One thousand years of fires: Integrating proxy and model data

    Science.gov (United States)

    Kehrwald, Natalie; Aleman, Julie C.; Coughlan, Michael; Courtney Mustaphi, Colin J.; Githumbi, Esther N.; Magi, Brian I.; Marlon, Jennifer R.; Power, Mitchell J.

    2016-01-01

    The current fires raging across Indonesia are emitting more carbon than the annual fossil fuel emissions of Germany or Japan, and the fires are still consuming vast tracts of rainforest and peatlands. The National Interagency Fire Center (www.nifc.gov) notes that 2015 is one worst fire years on record in the U.S., where more than 9 million acres burned -- equivalent to the combined size of Massachusetts and New Jersey. The U.S. and Indonesian fires have already displaced tens of thousands of people, and their impacts on ecosystems are still unclear. In the case of Indonesia, the burning peat is destroying much of the existing soil, with unknown implications for the type of vegetation regrowth. Such large fires result from a combination of fire management practices, increasing anthropogenic land use, and a changing climate.

  11. Thirty thousand-year-old evidence of plant food processing

    Czech Academy of Sciences Publication Activity Database

    Revedin, A.; Aranguren, B.; Becattini, R.; Longo, L.; Marconi, E.; Mariotti Lippi, M.; Skakun, N.; Sinitsyn, A.; Spiridonova, E.; Svoboda, Jiří

    2010-01-01

    Roč. 107, č. 44 (2010), s. 18815-18819 ISSN 0027-8424 Institutional research plan: CEZ:AV0Z80010507 Keywords : flour * Upper Paleolithic * grindstones * diet * starch grains Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Archaeology Impact factor: 9.771, year: 2010 http://www.pnas.org/content/pnas/107/44/18815.full.pdf

  12. Twenty years and twenty thousand contact lens patients.

    OpenAIRE

    Dixon, J M

    1981-01-01

    A self contained non commercial private office laboratory staffed by office personnel has been used to prepare contact lenses for private office patients. These lenses include hard contact lenses of various materials and various designs. During the past ten years extended wear hydrophilic soft lenses have been prepared in the same manner as hard lenses, all custom made with lens powers, base curves, diameters, and thickness designed according to the needs of each patient. This has provided st...

  13. Twenty years and twenty thousand contact lens patients.

    Science.gov (United States)

    Dixon, J M

    1981-01-01

    A self contained non commercial private office laboratory staffed by office personnel has been used to prepare contact lenses for private office patients. These lenses include hard contact lenses of various materials and various designs. During the past ten years extended wear hydrophilic soft lenses have been prepared in the same manner as hard lenses, all custom made with lens powers, base curves, diameters, and thickness designed according to the needs of each patient. This has provided strict medical supervision and lens maintenance with maximum convenience for patients and the ophthalmologist.

  14. One Thousand Pediatric Liver Transplants During Thirty Years: Lessons Learned.

    Science.gov (United States)

    Venick, Robert S; Farmer, Douglas G; Soto, Jose R; Vargas, Jorge; Yersiz, Hasan; Kaldas, Fady M; Agopian, Vatche G; Hiatt, Jonathan R; McDiarmid, Sue V; Busuttil, Ronald W

    2018-02-02

    Pediatric liver transplantation (pLTx) has been the standard of care for children with liver failure since the 1980s. This study examined the world's largest single-center experience and aimed to identify unique preoperative predictors of early graft and patient survival for primary transplantation (1°-pLTx) and retransplantation (Re-pLTx). We conducted an IRB-approved, retrospective study of all consecutive, isolated pLTx patients 18 years of age or younger. Twenty-eight demographic, laboratory, and perioperative variables were analyzed as potential outcome predictors. Univariate and multivariate analyses were performed using log-rank test and Cox's proportional hazards model. There were 806 children who received 1,016 isolated pLTx between February1984 and June 2017. Median follow-up was 12 years. Leading indications for pLTx were cholestatic liver disease (40%), re-pLTx (21%), and fulminant hepatic failure (14%). Seventy-three percent received cadaveric whole grafts. Overall graft and patient survival rates at 0.5, 1, 5, 10, and 20 years were: 76%, 73%, 67%, 63%, 53%, and 87%, 86%, 81%, 78%, 69%, respectively. Relative to 1°-pLTx, re-pLTx recipients were significantly older, larger, with worse renal function, and more likely to be awaiting pLTx in an ICU. Independent significant predictors of graft survival for 1°-pLTx included weight, transplantation era, and renal replacement therapy; for re-pLTx, warm ischemia time and time between 1°-pLTx and re-pLTx. Independent significant predictors of patient survival were renal function, mechanical ventilation, and etiology of liver disease. This is the largest reported single-center experience of pLTx with substantial follow-up time and a large re-pLTx experience. Important transplant predictors of graft survival include weight, renal function, modern era, warm ischemia time, and time between primary transplantation and re-pLTx. Renal function, mechanical ventilation, and underlying cause of liver disease affect

  15. One hundred thousand years back and forth: When archaeology meets radioactive waste

    International Nuclear Information System (INIS)

    Holtorf, Cornelius; Hoegberg, Anders

    2012-01-01

    This presentation discussed the final repository of radioactive waste as an issue at the interface of the sciences and the humanities. Archaeologists have learned that a hundred thousand years ago abstract thought and symbolism by humans began. Since then many communities of human beings have succeeded each other. They often intended to leave a mark for eternity, but they established in fact the truism that nothing ages faster than the future. Archaeologists and historians are promoting remembering, learning and understanding of history for contemporary and future generations. Disposal sites of nuclear waste constitute a special case of heritage. We are creating a very distinctive kind of heritage that in the future may be remembered or forgotten, just like any other heritage we create. The presentation addressed what the realms of heritage and radioactive waste disposal can learn from each other regarding making provisions for the future. Rubbish reflects the conditions from which it originates. The final deposition of radioactive waste is by nature a question of historical consciousness and future uses of the past, of memory and forgetting, and of future didactics of history. Heritage studies as well as history and archaeology are thus inherently relevant. Similarities between archaeology and RWM were thus pointed out, for instance the long time frames, specific sites, dealing with the meaning of rubbish, the fact that we both like to think we are doing something good for future generations,.. But there also are differences, notably that archaeology works with precious objects one wishes to keep. How will the future use our present, which is their past, for their own future? The meaning people give to information is important, and meaning is a continuous process of reinterpreting

  16. DITTY - a computer program for calculating population dose integrated over ten thousand years

    International Nuclear Information System (INIS)

    Napier, B.A.; Peloquin, R.A.; Strenge, D.L.

    1986-03-01

    The computer program DITTY (Dose Integrated Over Ten Thousand Years) was developed to determine the collective dose from long term nuclear waste disposal sites resulting from the ground-water pathways. DITTY estimates the time integral of collective dose over a ten-thousand-year period for time-variant radionuclide releases to surface waters, wells, or the atmosphere. This document includes the following information on DITTY: a description of the mathematical models, program designs, data file requirements, input preparation, output interpretations, sample problems, and program-generated diagnostic messages

  17. DITTY - a computer program for calculating population dose integrated over ten thousand years

    Energy Technology Data Exchange (ETDEWEB)

    Napier, B.A.; Peloquin, R.A.; Strenge, D.L.

    1986-03-01

    The computer program DITTY (Dose Integrated Over Ten Thousand Years) was developed to determine the collective dose from long term nuclear waste disposal sites resulting from the ground-water pathways. DITTY estimates the time integral of collective dose over a ten-thousand-year period for time-variant radionuclide releases to surface waters, wells, or the atmosphere. This document includes the following information on DITTY: a description of the mathematical models, program designs, data file requirements, input preparation, output interpretations, sample problems, and program-generated diagnostic messages.

  18. The ten-thousand year fever: rethinking human and wild primate malarias

    National Research Council Canada - National Science Library

    Cormier, Loretta A

    2011-01-01

    "Malaria is one of the oldest recorded diseases in human history, and its 10,000-year relationship to primates can teach us why it will be one of the most serious threats to humanity in the 21st century...

  19. Pieces of a thousand stories: repatriation of the history of Aboriginal Sydney

    Directory of Open Access Journals (Sweden)

    Peter Read

    2010-09-01

    Full Text Available The on-line project A History of Aboriginal Sydney, based at the University of Sydney, takes existing educational and Australian Indigenous digital initiatives in a new direction. By dividing Sydney into six geographical areas, we are creating a knowledge base of post-invasion Aboriginal history, incorporating different forms of tagging, timeline and digital mapping to provide multiple paths to information in text, videos, still images and, in the future, three dimensional reconstructions of former living areas. After eighteen months research we are maintaining a balance between unearthing new and forgotten material, incorporating it into our developing database, and exploring the potential of digital mapping, animation and 3D historical reconstruction for educational and research purposes. With close Indigenous consultation, especially the Aboriginal Educational Consultative Groups, we hope to digitally construct the Aboriginal history of Sydney and return it to the people who have been deprived of so much of their history for so long.

  20. Specific Chemical and Genetic Markers Revealed a Thousands-Year Presence of Toxic Nodularia spumigena in the Baltic Sea.

    Science.gov (United States)

    Cegłowska, Marta; Toruńska-Sitarz, Anna; Kowalewska, Grażyna; Mazur-Marzec, Hanna

    2018-04-04

    In the Baltic Sea, diazotrophic cyanobacteria have been present for thousands of years, over the whole brackish water phase of the ecosystem. However, our knowledge about the species composition of the cyanobacterial community is limited to the last several decades. In the current study, the presence of species-specific chemical and genetic markers in deep sediments were analyzed to increase the existing knowledge on the history of toxic Nodularia spumigena blooms in the Baltic Sea. As chemical markers, three cyclic nonribosomal peptides were applied: the hepatotoxic nodularin, which in the sea was detected solely in N. spumigena , and two anabaenopeptins (AP827 and AP883a) characteristic of two different chemotypes of this species. From the same sediment samples, DNA was isolated and the gene involved in biosynthesis of nodularin, as well as the phycocyanin intergenic spacer region (PC-IGS), were amplified. The results of chemical and genetic analyses proved for the first time the thousands-year presence of toxic N. spumigena in the Baltic Sea. They also indicated that through all this time, the same two sub-populations of the species co-existed.

  1. Is the fossil fuel hangover going to last for hundreds of thousands of years? (Invited)

    Science.gov (United States)

    Zeebe, R. E.

    2013-12-01

    Paleorecords show that the Paleocene-Eocene Thermal Maximum (PETM, 56 Ma) was associated with massive carbon release and global warming >5 K. The PETM is considered the best paleo-analog for massive carbon release and may provide insight into future changes in climate and ocean chemistry. Surprisingly, the paleorecords indicate little, if any decline in, for instance, stable carbon isotope values after 50 kyr. Similar durations of the PETM main phase can be inferred from oxygen isotope records (indicating temperature) and surface ocean carbonate chemistry proxies. The inferred main phase duration of > 50 kyr is also independent of the age model applied. Conventional carbon-cycle/climate models forced with an initial carbon input pulse over ~10 kyr fail to reproduce the long duration of the PETM without invoking additional, slow carbon release over more than 50 kyr. However, potential carbon sources and climate feedbacks that could amplify and prolong the warming have hitherto remained elusive. In this presentation, I will suggest plausible mechanisms for the long duration of the PETM based on first-principle calculations. If such mechanisms are also applicable to the future, the fossil fuel hangover (i.e. magnitude and duration of future warming), could last for hundreds of thousands of years.

  2. Long Island Sound Water Temperatures During the Last Two Thousand Years

    Science.gov (United States)

    Warren, C. E.; Varekamp, J. C.; Thomas, E.

    2010-12-01

    The Long Island Sound (LIS), sometimes called the “urban sea”, is a large estuary in the heavily populated coastal zone between New York City and the Connecticut - Rhode Island border. LIS has seen dramatic environmental shifts since colonial times, including major changes in aquatic food extraction, land use, contaminant and nutrient inputs, and climate change. Annual seasonal hypoxic/anoxic events, especially common in westernmost LIS, have been identified as potentially severe stressors for LIS biota including valuable fisheries species such as lobsters and shellfish. These conditions develop when the Sound becomes stratified in midsummer and oxygen consumption from the oxidation of organic matter exceeds oxygen resupply from the atmosphere or photosynthesis. Severity, lateral extent and frequency of hypoxia/anoxia is influenced by the amount of organic matter available for oxidation, both marine organic matter (produced by algal blooms in response to influx of N-rich effluents from waste water treatment plants) and terrestrial organic matter. These events are also influenced by the severity of stratification, determined by differences in density from temperature and salinity gradients of surface and bottom waters. Studies of cores in western and central LIS, dated using Hg-pollution profiles, 210Pb - 137Cs, and 14C, indicate that eutrophication and hypoxia have occurred in LIS only over the last ~150 years, with the possible exception of the Narrows (closest to NY) where it may have occurred before colonial times. Salinity decreased as well over the last 150 years, possibly due to changes in land use or deflection of fresh water from the Hudson River. Temperature variability in LIS over the last few thousand years has not been clearly documented, as several paleotemperature proxies are difficult to use in estuarine settings. Oxygen isotope values of carbonate microfossils are influenced by salinity fluctuations, and Mg/Ca values in these shells may be

  3. The Öland limestone - A Swedish stone used for more than one thousand years

    Science.gov (United States)

    Schouenborg, Björn; Wickström, Linda; Mikaelsson, Jan

    2016-04-01

    The second largest island in Sweden is the home of the "Öland limestone", a condensed and bedded limestone whose origin dates back to Lower Ordovician, i.e. about 480 M years ago. Öland is a part of the palaeocontinent Baltica that, at the time, was situated at low latitudes with deposition of the calcareous sediments in a cool water environment. The limestone on Öland represents a proximal ramp tectonic setting, with the oldest sediments deposited in the west and younger sediments deposited towards east and southeast. Fluctuating sea-levels have created erosional hard grounds such as the Flowery sheet. These hardgrounds are recognised by their vivid colours and trace fossils, and can be traced all over Baltica, but is maybe best represented on Öland. Ordovician limestones are present in many places in Sweden, but it is the occurrence on Öland that is the most renowned in a building stone perspective. One reason for this is the favourable trading location, an island off the Swedish East coast in middle of the trading routes between the Baltic countries and the continent. Other reasons are the pleasant aesthetical values with numerous orthoceratites and other fossils. The limestones on Öland differ in colour. From the red varieties (with oxidized iron) to brownish and grey. The bedding is mostly in the cm-scale which easily enables very exploitable thickness of slabs. Every mm limestone represents about 1000 years of deposition. The limestone has most likely been used in a very crude way for many thousand years, but archaeological evidence of a more industrialized usage is just a little more than 1000 years. It is known from the literature that the first official Swedish king, Gustav Vasa (16th century), desired this stone. At the time it was called "Öland marble", and the king "imported" specialists to process it further at the Royal Stone workshop on northern Öland. Remnants of tools and working sites still remain in an outdoor museum. Export of the

  4. The Holy Grail: Deterministic prediction of corrosion damage thousands of years into the future

    International Nuclear Information System (INIS)

    Macdonald, Digby D.

    2003-01-01

    This paper summarises work being carried out by the author, under Department of Energy (DoE) sponsorship, to develop general corrosion models for Alloy C-22 HLNW canisters in a Yucca Mountain type repository. Two models have been developed to date: (1) the General Corrosion Model (GCM), which yields the corrosion potential and corrosion rate at a specified state point (i.e. a point on the evolutionary path), and (2) the Accumulated Damage Model (ADM), which integrates the corrosion rate calculated for closely spaced state points along the evolutionary path to yield the corrosion loss over the history of the repository. The GCM is based upon the Point Defect Model (PDM) for the steady state growth of passive films on metal surfaces and upon the general Butler-Volmer equation for the kinetics of redox reactions (hydrogen evolution and oxygen reduction), both of which are combined within the framework of the Mixed Potential Model (MPM) to yield the desired corrosion potential and corrosion rate. Importantly, the solution of the constitutive equations contained within the MPM is constrained by the conservation of charge, thereby imparting a high degree of determinism to the predictions. Application of the ADM to evolutionary paths defined by the repository temperature, and assuming that the canisters are always in contact with saturated brine under ambient oxygen pressure conditions, yields a corrosion loss of about 1.7 mm over the 10 000-year service life of the repository. It is estimated that complete loss of the 2 cm Alloy C-22 wall would require an exposure time of about 200 000 years and that the corrosion loss after 1 000 000 years would be slightly less than 9 cm. (authors)

  5. Three Thousand Years of Continuity in the Maternal Lineages of Ancient Sheep (Ovis aries) in Estonia

    Science.gov (United States)

    Rannamäe, Eve; Lõugas, Lembi; Speller, Camilla F.; Valk, Heiki; Maldre, Liina; Wilczyński, Jarosław; Mikhailov, Aleksandr; Saarma, Urmas

    2016-01-01

    Although sheep (Ovis aries) have been one of the most exploited domestic animals in Estonia since the Late Bronze Age, relatively little is known about their genetic history. Here, we explore temporal changes in Estonian sheep populations and their mitochondrial genetic diversity over the last 3000 years. We target a 558 base pair fragment of the mitochondrial hypervariable region in 115 ancient sheep from 71 sites in Estonia (c. 1200 BC–AD 1900s), 19 ancient samples from Latvia, Russia, Poland and Greece (6800 BC–AD 1700), as well as 44 samples of modern Kihnu native sheep breed. Our analyses revealed: (1) 49 mitochondrial haplotypes, associated with sheep haplogroups A and B; (2) high haplotype diversity in Estonian ancient sheep; (3) continuity in mtDNA haplotypes through time; (4) possible population expansion during the first centuries of the Middle Ages (associated with the establishment of the new power regime related to 13th century crusades); (5) significant difference in genetic diversity between ancient populations and modern native sheep, in agreement with the beginning of large-scale breeding in the 19th century and population decline in local sheep. Overall, our results suggest that in spite of the observed fluctuations in ancient sheep populations, and changes in the natural and historical conditions, the utilisation of local sheep has been constant in the territory of Estonia, displaying matrilineal continuity from the Middle Bronze Age through the Modern Period, and into modern native sheep. PMID:27732668

  6. Five thousand years of tropical lake sediment DNA records from Benin

    Science.gov (United States)

    Bremond, L.; Favier, C.; Ficetola, G. F.; Tossou, M. G.; Akouégninou, A.; Gielly, L.; Giguet-Covex, C.; Oslisly, R.; Salzmann, U.

    2017-08-01

    Until now, sedimentary DNA (sedDNA) studies have only focused on cold and temperate regions were DNA is relatively well preserved. Consequently, the tropics, where vegetation is hyperdiverse and natural archives are rare, have been neglected and deserve attention. In this study, we used next-generation sequencing to barcode sedDNA from Lake Sele, localized in the tropical lowlands of Benin (Africa), and compared the taxonomic diversity detected by DNA analyses with pollen assemblages. Plant sedDNA was successfully amplified from 33 of the 34 successfully extracted samples. In total, 43 taxa were identified along the 5000 years spanned by the sediment: 22 taxa were identified at the family level and 21 at the genus level. The plant diversity recovered through sedDNA from Lake Sele showed a specific local signal and limited overlapping with pollen. Introduced plants, grown and cultivated close to the water, such as sweet potato, were also well recorded by sedDNA. It appears, therefore, to be a promising approach to studying past diversity in tropical regions, and could help in tracking the introduction and history of agriculture. This is the first time this method has been used in the field of domestication and dissemination of several specific crops, and the results are very encouraging.

  7. Three Thousand Years of Continuity in the Maternal Lineages of Ancient Sheep (Ovis aries) in Estonia.

    Science.gov (United States)

    Rannamäe, Eve; Lõugas, Lembi; Speller, Camilla F; Valk, Heiki; Maldre, Liina; Wilczyński, Jarosław; Mikhailov, Aleksandr; Saarma, Urmas

    2016-01-01

    Although sheep (Ovis aries) have been one of the most exploited domestic animals in Estonia since the Late Bronze Age, relatively little is known about their genetic history. Here, we explore temporal changes in Estonian sheep populations and their mitochondrial genetic diversity over the last 3000 years. We target a 558 base pair fragment of the mitochondrial hypervariable region in 115 ancient sheep from 71 sites in Estonia (c. 1200 BC-AD 1900s), 19 ancient samples from Latvia, Russia, Poland and Greece (6800 BC-AD 1700), as well as 44 samples of modern Kihnu native sheep breed. Our analyses revealed: (1) 49 mitochondrial haplotypes, associated with sheep haplogroups A and B; (2) high haplotype diversity in Estonian ancient sheep; (3) continuity in mtDNA haplotypes through time; (4) possible population expansion during the first centuries of the Middle Ages (associated with the establishment of the new power regime related to 13th century crusades); (5) significant difference in genetic diversity between ancient populations and modern native sheep, in agreement with the beginning of large-scale breeding in the 19th century and population decline in local sheep. Overall, our results suggest that in spite of the observed fluctuations in ancient sheep populations, and changes in the natural and historical conditions, the utilisation of local sheep has been constant in the territory of Estonia, displaying matrilineal continuity from the Middle Bronze Age through the Modern Period, and into modern native sheep.

  8. Four-thousand-year-old gold artifacts from the Lake Titicaca basin, southern Peru.

    Science.gov (United States)

    Aldenderfer, Mark; Craig, Nathan M; Speakman, Robert J; Popelka-Filcoff, Rachel

    2008-04-01

    Artifacts of cold-hammered native gold have been discovered in a secure and undisturbed Terminal Archaic burial context at Jiskairumoko, a multicomponent Late Archaic-Early Formative period site in the southwestern Lake Titicaca basin, Peru. The burial dates to 3776 to 3690 carbon-14 years before the present (2155 to 1936 calendar years B.C.), making this the earliest worked gold recovered to date not only from the Andes, but from the Americas as well. This discovery lends support to the hypothesis that the earliest metalworking in the Andes was experimentation with native gold. The presence of gold in a society of low-level food producers undergoing social and economic transformations coincident with the onset of sedentary life is an indicator of possible early social inequality and aggrandizing behavior and further shows that hereditary elites and a societal capacity to create significant agricultural surpluses are not requisite for the emergence of metalworking traditions.

  9. Thousand-year-long Chinese time series reveals climatic forcing of decadal locust dynamics.

    Science.gov (United States)

    Stige, Leif Christian; Chan, Kung-Sik; Zhang, Zhibin; Frank, David; Stenseth, Nils C

    2007-10-09

    For >1,000 years, Chinese officials have recorded the annual abundance of the oriental migratory locust Locusta migratoria manilensis, with the ultimate aim of predicting locust outbreaks. Linking these records with temperature and precipitation reconstructions for the period 957-1956, we show that decadal mean locust abundance is highest during cold and wet periods. These periods coincide with above-average frequencies of both floods and droughts in the lower Yangtze River, phenomena that are associated with locust outbreaks. Our results imply differential ecological responses to interdecadal and interannual climatic variability. Such frequency-dependent effects deserve increased attention in global warming studies.

  10. Fourteen Thousand Solar Systems and Growing: Results From the Starchitect Online Game at One Year

    Science.gov (United States)

    Harold, J. B.

    2015-12-01

    Starchitect (www.starchitect.net) is an online, end-to-end stellar and planetary evolution game designed to teach players about a variety of astronomy and planetary topics. Supported by NASA and NSF, and developed at the National Center for Interactive Learning at the Space Science Institute, the game uses the "sporadic play" model of games such as Farmville, where players might only take actions a few times a day, but continue playing for months. This framework is a natural fit for teaching about the evolution of stars and planets. Starchitect's systems evolve at a million years a minute, so that while massive stars will supernova almost immediately, lower mass stars like our sun will live for weeks of game time, possibly evolving life before passing through a red giant stage and ending their lives as white dwarfs. The game has now been live for over a year, playable both on Facebook and externally, and over 14,000 solar systems have been created by over 11,000 players. Since the game itself is heavily instrumented we now have access to a wealth of data that can be used to examine how people are playing the game and what tasks they are successfully engaging with. Through an embedded quiz game we are even in the position to assess the prior knowledge of our audience and execute pre/post assessments tied to game play. This paper will briefly describe the game and its educational strategies, then summarize some of our current results.

  11. Last nine-thousand years of temperature variability in Northern Europe

    Directory of Open Access Journals (Sweden)

    H. Seppä

    2009-09-01

    Full Text Available The threat of future global warming has generated a major interest in quantifying past climate variability on centennial and millennial time-scales. However, palaeoclimatological records are often noisy and arguments about past variability are only possible if they are based on reproducible features in several reliably dated datasets. Here we focus on the last 9000 years, explore the results of 36 Holocene pollen-based July mean and annual mean temperature reconstructions from Northern Europe by stacking them to create summary curves, and compare them with a high-resolution, summary chironomid-based temperature record and other independent palaeoclimate records. The stacked records show that the "Holocene Thermal Maximum" in the region dates to 8000 to 4800 cal yr BP and that the "8.2 event" and the "Little Ice Age" at 500–100 cal yr BP are the clearest cold episodes during the Holocene. In addition, a more detailed analysis of the last 5000 years pinpoints centennial-scale climate variability with cold anomalies at 3800–3000 and 500–100 cal yr BP, a long, warmer period around 2000 cal yr BP, and a marked warming since the mid 19th century. The colder (warmer anomalies are associated with increased (decreased humidity over the northern European mainland, consistent with the modern high correlation between cold (warm and humid (dry modes of summer weather in the region. A comparison with the key proxy records reflecting the main forcing factors does not support the hypothesis that solar variability is the cause of the late-Holocene centennial-scale temperature changes. We suggest that the reconstructed anomalies are typical of Northern Europe and their occurrence may be related to the oceanic and atmospheric circulation variability in the North Atlantic – North-European region.

  12. The impact of low level radioactive waste on humans and environment the next 100 thousands years

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, E.; Saetre, P.; Lindborg, T.; Norden, S.; Kautsky, U. [Svensk Kaernbraenslehantering AB - SKB (Sweden); Loefgren, A. [Ecoanalytica, Stockholm (Sweden)

    2014-07-01

    A safety assessment for the extension of the low level repository of operational waste (SFR) has been performed (SR-PSU). The repository (both existing and planned extension) is situated c 60 - 120 m below the surface in archaean granitoid rock. SR-PSU evaluates the risk to humans and the environment for the next 100 000 years. During this time period considerable changes are expected in the surface environment due climate change and its effects on shore line displacement, terrestrialisation of lakes and expansion of forest and agricultural land. In this paper specific approaches and results for the surface ecosystems (i.e. biosphere) are presented. The transport and accumulation of radionuclides in marine, lake, and terrestrial ecosystems are modelled and expose of future human populations during present conditions, greenhouse warming, and peri-glacial climate conditions are estimated taking into account different habits and diets of future humans. A new radionuclide transport model was developed to improve the representation of C-14 in the ecosystem modelling. In SR-PSU it is shown that the primary release from the repository via the geosphere to the biosphere is focused to a small area that will be a mire in about 1000 year. The radionuclides can thereafter be transported to downstream lakes and sea ecosystems. The aquatic systems can be utilised for fish and water whereas the mire can either be utilised directly by e.g. collecting, mushroom berries, hay, or hunting, or the mire can be transformed to a small agricultural area and utilised for crops. Important dose contributing radionuclides from SFR are Cl-36, Mo-93, C-14, Ni-59 and I-129 and in some of the scenarios the dose is close to the regulatory limit of 14 μSv/y (i.e. the risk 10{sup -6}). For Non-human biota (NHB) doses are estimated with a novel implementation of the ERICA tool in Ecolego. Generally the same radionuclides contributes to dose to NHB (reference organisms and site -specific organisms) as

  13. Linking two thousand years of European historical records with environmental change recorded in a high Alpine ice core

    Science.gov (United States)

    Bohleber, Pascal; Spaulding, Nicole; Mayewski, Paul; Kurbatov, Andrei; Hoffmann, Helene; Erhardt, Tobias; Fischer, Hubertus; More, Alexander; Loveluck, Christopher; Luongo, Matthew; Kabala, Jakub; McCormick, Michael

    2016-04-01

    Its extraordinary network of historical and archaeological records makes Europe exceptionally promising for investigating environmental change and human response over the last two thousand years. Among natural proxy archives, ice core records offer a wide range of environmental reconstructions including natural and human source histories of the chemistry of the atmosphere. To link these robust environmental records with historical evidence of past civilizations remains a great challenge, however. In central Europe the unique target for a comparison for environmental change recorded in ice cores and human activity is the small firn saddle of Colle Gnifetti (4550 m above sea level on the Italian-Swiss border). Its exceptionally low net accumulation make Colle Gnifetti (CG) the only feasible site in the Alps for retrieving a long-term ice core record beyond the last century. However, at CG rapid annual layer thinning eventually limits conventional cm-resolution analysis to multi-annual signals and hampers dating by annual layer counting beyond a few hundred years. Thereby, a crucial gap is introduced to the sub-seasonal time scale of events typically recorded in written archives. In our ongoing project we pioneer correlating the CG environmental ice core archive with a unique compilation of European historical records provided through the Harvard Initiative for the Science of the Human Past and the Digital Atlas of Roman and Medieval Civilization. For this purpose, state-of-the-art glacio-chemical analysis was performed on a newly recovered CG ice core, including continuous flow analysis chemistry and stable isotopes. A crucial contribution comes from the application of LA-ICP-MS (laser ablation ion coupled plasma mass spectrometry) to meter long sections of frozen ice samples, developed and operated by the University of Maine's Climate Change Institute, offering glacio-chemical records up to 100 μm in resolution. The new methods significantly improves sampling

  14. Ten-year survival and prognostic markers in one thousand patients with advanced heart failure. A single-centre analysis.

    Science.gov (United States)

    Lesny, Peter; Luknar, Milan; Matejka, Martin; Varga, Ivan; Solik, Peter; Wimmerova, Sona; Goncalvesova, Eva

    2016-06-01

    Patients with advanced heart failure (HF) represent a pool of candidates for heart transplantation and long-term mechanical circulatory support devices. The aim of our study was to determine simple and reliable markers of one-year mortality for selection of the most suitable patients for heart replacement therapy. One thousand consecutive patients with HF (mean age 49 ± 10.9 years; 86.8% males) referred to a single tertiary centre from January 1998 to January 2010 in order to assess the indication for heart transplantation were enrolled. Kaplan-Meier survival analysis was performed. Independent mortality predictors were established using logistic regression analysis. The mean follow-up was 4.3 ± 2.7 years (range 1-12 years). Cumulative survival was as follows: 1-year survival 83%, 3-year 63%, 5-year 50%, 7-year 39%, and 10-year 23%. Independent predictors of 1-year mortality included coronary artery disease, left ventricular diastolic diameter >79 mm, plasma sodium 240 mg/day. Short-term prognosis of HF patient can be estimated based on simple parameters. Patients with signs of poor prognosis should be referred to tertiary centres to be considered for heart replacement therapy.

  15. Fifty-thousand-year vegetation and climate history of Noel Kempff Mercado National Park, Bolivian Amazon

    Science.gov (United States)

    Burbridge, Rachel E.; Mayle, Francis E.; Killeen, Timothy J.

    2004-03-01

    Pollen and charcoal records from two large, shallow lakes reveal that throughout most of the past 50,000 yr Noel Kempff Mercado National Park, in northeastern lowland Bolivia (southwestern Amazon Basin), was predominantly covered by savannas and seasonally dry semideciduous forests. Lowered atmospheric CO 2 concentrations, in combination with a longer dry season, caused expansion of dry forests and savannas during the last glacial period, especially at the last glacial maximum. These ecosystems persisted until the mid-Holocene, although they underwent significant species reassortment. Forest communities containing a mixture of evergreen and semideciduous species began to expand between 6000 and 3000 14C yr B.P. Humid evergreen rain forests expanded to cover most of the area within the past 2000 14C yr B.P., coincident with a reduction in fire frequencies. Comparisons between modern pollen spectra and vegetation reveal that the Moraceae-dominated rain forest pollen spectra likely have a regional source area at least 2-3 km beyond the lake shore, whereas the grass- and sedge-dominated savanna pollen spectra likely have a predominantly local source area. The Holocene vegetation changes are consistent with independent paleoprecipitation records from the Bolivian Altiplano and paleovegetation records from other parts of southwestern Amazonia. The progressive expansion in rain forests through the Holocene can be largely attributed to enhanced convective activity over Amazonia, due to greater seasonality of insolation in the Southern Hemisphere tropics driven by the precession cycle according to the Milankovitch Astronomical Theory.

  16. Landscape change and human response during a thousand years of climatic fluctuation and volcanism: Skaftafell, Southeast Iceland

    Directory of Open Access Journals (Sweden)

    Ives, Jack D.

    1991-06-01

    Full Text Available climatic fluctuation and volcanism: Skaftafell, Southeast Iceland ABSTRACT- The ancient farm of Skaftafell, dating from the Saga Period in Icelandic history is taken as the center-piece for depiction of climatic and landscape change from the earliest settlement in the ninth century AD to the present. The study of landscape evolution is divided into four main periods: 1 the Saga Period, AD 874-1350; 2 the beginning of glacier advance and volcanic activity, AD 1350-1500; 3 the Little Ice Age, AD 1500-1900; and 4 the Modern Period, AD 1900-1990. Is/laps have been produced to represent each period; they show the positions of farms which have survived far more than a thousand years, and churches that have been overwhelmed by catastrophic geomorphic processes, the positions of the glacier termini, melt water rivers, and main pasture lands. These reconstructions are based upon a mixture of physical evidence and folklore and historical documentation. Landscape evaluation is also described through the eyes of historic personalities who lived at Skaftafell. Survival of a rich culture in this region is remarkable in face of a series of almost overwhelming disasters. Today the biggest threat, or challenge and opportunity for sustainable development, is the vast influx of tourists to this region, one of the most isolated in the world. They are drawn to Skaftafell through the establishment of a National Park in one of the most scenically dramatic and beautiful landscapes in the world.

    [es] La antigua granja de Skaftafell, que data del período de Sagas de la Historia islandesa se ha tomado como el eje en torno al cual gira la explicación de los cambios climáticos y paisajísticos que han tenido lugar desde el primitivo asentamiento del siglo IX hasta el presente. El estudio de la evolución del paisaje se divide en cuatro períodos principales: 1 El Período de Sagas, 874-1350; 2 El principio del avance glaciar y la actividad volcánica, 1350

  17. East African megadroughts between 135 and 75 thousand years ago and bearing on early-modern human origins.

    Science.gov (United States)

    Scholz, Christopher A; Johnson, Thomas C; Cohen, Andrew S; King, John W; Peck, John A; Overpeck, Jonathan T; Talbot, Michael R; Brown, Erik T; Kalindekafe, Leonard; Amoako, Philip Y O; Lyons, Robert P; Shanahan, Timothy M; Castañeda, Isla S; Heil, Clifford W; Forman, Steven L; McHargue, Lanny R; Beuning, Kristina R; Gomez, Jeanette; Pierson, James

    2007-10-16

    The environmental backdrop to the evolution and spread of early Homo sapiens in East Africa is known mainly from isolated outcrops and distant marine sediment cores. Here we present results from new scientific drill cores from Lake Malawi, the first long and continuous, high-fidelity records of tropical climate change from the continent itself. Our record shows periods of severe aridity between 135 and 75 thousand years (kyr) ago, when the lake's water volume was reduced by at least 95%. Surprisingly, these intervals of pronounced tropical African aridity in the early late-Pleistocene were much more severe than the Last Glacial Maximum (LGM), the period previously recognized as one of the most arid of the Quaternary. From these cores and from records from Lakes Tanganyika (East Africa) and Bosumtwi (West Africa), we document a major rise in water levels and a shift to more humid conditions over much of tropical Africa after approximately 70 kyr ago. This transition to wetter, more stable conditions coincides with diminished orbital eccentricity, and a reduction in precession-dominated climatic extremes. The observed climate mode switch to decreased environmental variability is consistent with terrestrial and marine records from in and around tropical Africa, but our records provide evidence for dramatically wetter conditions after 70 kyr ago. Such climate change may have stimulated the expansion and migrations of early modern human populations.

  18. An eighty years long history

    Directory of Open Access Journals (Sweden)

    Gianfranco Fabbio

    2013-12-01

    Full Text Available An eighty years long historyAnnals of Silvicultural Research (ASR take over and are the on line follow-up of the former Annali. The Annali are a body of 36 volumes issued since 1970 from the Experimental Institute of Silviculture, then Forestry Research Centre of the Consiglio per la Ricerca e la sperimentazione in Agricoltura (CRA. They originate from the series of Papers of the same Institution (n. 15-18, 1968-69 and formerly of the Royal Station of Silviculture in Firenze (n. 1-14, 1932-67. The history of Annals dates therefore back to 80 years ago and covers quite completely the activity of our Institution since its early establishment in Firenze in 1922.Institutional duty of the Annali was the scientific dissemination of research trials’ outcomes and findings to the manifold stakeholders’ levels and was aimed at an effective transfer of knowledge and innovation in the practice of forestry. The Annali housed original research papers produced inside and in cooperation with researchers outside on the subject-matters of forest ecology, silviculture of semi-natural forests and forest plantations for environmental restoration and wood/ non-wood productions, tree farming and agro-forestry, forest mensuration and stand dynamics, dendro-ecology, conservation and valorization of genetic resources and levels and types of biodiversity, protection and provision of forest ecosystems services, maintenance of their multifunctional role, up to the more recent theme of the adaptive management framed within the environmental change in progress and related issues of forests’ mitigation & carbon sequestration/ stocking ability.A review of research topics and thematic volumes handled throughout the eighty years highlights the attention paid towards the national emerging subject-matters, since the Experiments on the introduction of exotic species in Italy by Pavari and De Philippis (1941, to its conclusive follow-up forty years later Role of exotic species

  19. Seven thousand years of records on the mining and utilization of metals from lake sediments in central China.

    Science.gov (United States)

    Lee, Celine S L; Qi, Shi-Hua; Zhang, Gan; Luo, Chun-Ling; Zhao, Lu Y L; Li, Xiang-Dong

    2008-07-01

    A 268 cm section of sediment core from Liangzhi Lake in Hubei province in central China was used to assess the use and accumulation of metals in the lake in the past 7,000 years. The concentrations of trace metals, including Cu, Pb, Ni, and Zn, and major elements, Ca, Fe, and Mg, in a 14C- dated segment of sediment core were analyzed. Historical trends on the input of metals to Liangzhi Lake from around 5000 BC to the present were recorded in the sediments, representing about 7,000 years of history on the mining and utilization of metals in central China. The concentrations of Cu, Ni, Pb, and Zn increased gradually from about 3000 +/- 328 BC, indicating the start of the Bronze Age in ancient China. During the period 467 +/- 257 to 215 +/- 221 AD, there was a rapid increase in the concentrations of these metals in the sediments, indicating enormous inputs of these metals at that time. This era corresponded to China's Warring States Period (475- 221 BC) and the early Han Dynasty (206 BC-220 AD), during which copper and lead were extensively used in making bronze articles such as vessels, tools, and weapons. From 1880 +/- 35 AD to the early 1900s, there was also a significant increase in the concentrations of metals such as Cu, Ni, and Pb, which probably reflected the metal emissions and utilization during the early period of industrial development and weapon manufacture during the wars in China. The Pb isotopic analysis showed that the surface and subsurface sediments had lower 206Pb/207Pb and 208Pb/ 207Pb ratios than the deeper layers, reflecting the additional input of Pb from mining activities that took place during the Bronze Age era and in modern times. This study provides direct evidence of the environmental impact of the mining and utilization of metals in the last 7,000 years in one of the important regions of Chinese civilization.

  20. WFIRST: Extragalactic Science over Twelve Billion Years of Cosmic History

    Science.gov (United States)

    Dickinson, Mark; Robertson, Brant; Ferguson, Henry C.; Furlanetto, Steve; Greene, Jenny; Madau, Piero; Marrone, Dan; Shapley, Alice; Stark, Daniel P.; Wechsler, Risa; Woosley, Stan; WFIRST-EXPO Science Investigation Team

    2018-01-01

    WFIRST’s infrared multiband imaging and spectroscopy from space over thousands of square degrees will revolutionize our understanding of galaxy formation and evolution. When combined with unique guest observer programs that provide ultradeep IR imaging and spectroscopy over areas >100x larger than achieved by Hubble Space Telescope, WFIRST will provide the first complete picture of star formation and stellar mass build-up in galaxies over twelve billion years of cosmic history. The WFIRST Extragalactic Potential Observations (WFIRST-EXPO) Science Investigation Team has identified a host of guest observer and archival programs where WFIRST can transform our views of the connections between the star formation, environment, morphology, stellar mass, and dark matter halo properties of galaxies, and determined how WFIRST can singularly probe the connection between early galaxies and the process of cosmic reionization. We present these WFIRST capabilities, and discuss how the science from WFIRST relates to other major forthcoming space- and ground-based facilities.

  1. Oxygen - A Four Billion Year History

    DEFF Research Database (Denmark)

    Canfield, Donald Eugene

    The air we breathe is twenty-one percent oxygen, an amount higher than on any other known world. While we may take our air for granted, Earth was not always an oxygenated planet. How did it become this way? Oxygen is the most current account of the history of atmospheric oxygen on Earth. Donald...... Canfield--one of the world's leading authorities on geochemistry, earth history, and the early oceans--covers this vast history, emphasizing its relationship to the evolution of life and the evolving chemistry of the Earth. With an accessible and colorful first-person narrative, he draws from a variety...... the records of oxygen concentrations through time. Readers learn about the great oxidation event, the tipping point 2.3 billion years ago when the oxygen content of the Earth increased dramatically, and Canfield examines how oxygenation created a favorable environment for the evolution of large animals. He...

  2. Nine thousand years of upper montane soil/vegetation dynamics from the summit of Caratuva Peak, Southern Brazil

    Science.gov (United States)

    Scheer, Maurício B.; Pereira, Nuno Veríssimo; Behling, Hermann; Curcio, Gustavo R.; Roderjan, Carlos V.

    2014-12-01

    Biodiversity loss, climate change, and increased freshwater consumption are some of the main environmental problems on Earth. Mountain ecosystems can reduce these threats by providing several positive influences, such as the maintenance of biodiversity, water regulation, and carbon storage, amongst others. The knowledge of the history of these environments and their response to climate change is very important for management, conservation, and environmental monitoring programs. The genesis of the soil organic matter of the current upper montane vegetation remains unclear and seems to be quite variable depending on location. Some upper montane sites in the very extensive coastal Sea Mountain Range present considerable organic matter from the late Pleistocene and other from only the Holocene. Our study was carried out on three soil profiles (two cores in grassland and one in forest) on the Caratuva Peak of the Serra do Ibitiraquire (a sub-range of Sea Mountain Range - Serra do Mar) in Southern Brazil. The δ13C isotopic analyses of organic matter in soil horizons were conducted to detect whether C3 or C4 plants dominated the past communities. Complementarily, we performed a pollen analysis and 14C dating of the humin fraction to obtain the age of the studied horizons. Except for a short and probably drier period (between 6000 and 4500 cal yr BP), C3 plants, including ombrophilous grasses and trees, have dominated the highlands of the Caratuva Peak (Pico Caratuva), as well as the other uppermost summits of the Serra do Ibitiraquire, since around 9000 cal yr BP. The Caratuva region represents a landscape of high altitude grasslands (campos de altitude altomontanos or campos altomontanos) and upper montane rain/cloud forests with soils that most likely contain some organic matter from the late Pleistocene, as has been reported in Southern and Southeastern Brazil for other sites. However, our results indicate that the studied deposits (near the summit) are from the early

  3. History of 10 years of KEPCO

    International Nuclear Information System (INIS)

    1985-10-01

    This book is the history of Korea power engineering company for 10 years. It describes the background of establishment of the company and development of nuclear energy and engineering, the procession of the establishment, the course of development in three parts of period, organization of the company, the progression of the business in the nuclear energy, hydraulic power and thermal power, development of technique and manpower and management for prospect of the company.

  4. Forty Thousand Years of Advertisement

    Directory of Open Access Journals (Sweden)

    Konstantin Lidin

    2006-05-01

    Full Text Available The roots of advertisement are connected with reclamations, claims and arguments. No surprise that many people treat it with distrust, suspicion and irritation.Nobody loves advertisement (except its authors and those who order it, nobody watches it, everybody despises it and get annoyed because of it. But newspapers, magazines, television and city economy in general cannot do without it. One keeps on arguing whether to prohibit advertisement, to restrict its expansion, to bring in stricter regulations on advertisement…If something attracts attention, intrigues, promises to make dreams true and arouses desire to join - it should be considered as advertisement. This definition allows saying with no doubts: yes, advertisement did existed in the most ancient strongest cultures. Advertisement is as old as the humane civilization. There have always been the objects to be advertised, and different methods appeared to reach those goals.Advertisement techniques and topics appear, get forgotten and appear again in other places and other times. Sometimes the author of advertisement image has no idea about his forerunners and believes he is the discoverer. A skillful designer with high level of professionalism deliberately uses images from past centuries. The professional is easily guided by historical prototypes.But there is another type of advertisement, its prototypes cannot be found in museums. It does not suppose any respect, because it is built on scornful attitude towards the spectator.However, basically the advertisement is made by professional designers, and in this case ignorance is inadmissible. Even if we many times appeal to Irkutsk designers to work on raising their cultural level of advertisements, anyhow, orders will be always made by those who pay. Unless Its Majesty Ruble stands for Culture, those appeals are of no use.

  5. Oxygen - A Four Billion Year History

    DEFF Research Database (Denmark)

    Canfield, Donald Eugene

    The air we breathe is twenty-one percent oxygen, an amount higher than on any other known world. While we may take our air for granted, Earth was not always an oxygenated planet. How did it become this way? Oxygen is the most current account of the history of atmospheric oxygen on Earth. Donald...... of fields, including geology, paleontology, geochemistry, biochemistry, animal physiology, and microbiology, to explain why our oxygenated Earth became the ideal place for life. Describing which processes, both biological and geological, act to control oxygen levels in the atmosphere, Canfield traces...... the records of oxygen concentrations through time. Readers learn about the great oxidation event, the tipping point 2.3 billion years ago when the oxygen content of the Earth increased dramatically, and Canfield examines how oxygenation created a favorable environment for the evolution of large animals. He...

  6. 40 CFR 68.42 - Five-year accident history.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Five-year accident history. 68.42... (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Hazard Assessment § 68.42 Five-year accident history. (a) The owner or operator shall include in the five-year accident history all accidental releases from...

  7. 300 Years of Community History in Architecture

    Science.gov (United States)

    Schelling, Gloria

    2004-01-01

    Easttown Township chose to celebrate its tercentenary to create a greater awareness of local history. In this article, the author discusses how she incorporated this celebration into her art classroom. With history and architecture as the theme, sixth-grade art students researched homes and buildings in the township dating back as early as the…

  8. IQ in childhood and atherosclerosis in middle-age: 40 Year follow-up of the Newcastle Thousand Families Cohort Study.

    Science.gov (United States)

    Roberts, Beverly A; Batty, G David; Gale, Catharine R; Deary, Ian J; Parker, Louise; Pearce, Mark S

    2013-12-01

    Carotid intima-media thickness (IMT) is a known precursor to coronary heart disease (CHD) and other relevant health outcomes such as stroke and cognitive impairment. In addition, higher childhood intelligence has been associated with lower risk of coronary heart disease events in later life, although the mechanisms of effect are unclear. We therefore examined the association between childhood intelligence and atherosclerosis using carotid IMT as a marker of the atherosclerotic process. Participants were 412 members of the Newcastle Thousand Families Study, a prospective cohort study of all 1142 births in the city of Newcastle in May and June 1947, who took an IQ test and English and arithmetic tests at age 11 years. Study members participated in a medical examination and lifestyle assessment at age 49-51 years during which IMT was measured using ultrasound techniques. Individuals with higher childhood IQ score had a lower mean IMT in middle-age. A standard deviation higher score in childhood overall IQ was associated with a 0.053 mm (95% CI -0.102, -0.004) lower IMT in men and a 0.039 mm (95% CI -0.080, -0.002) lower IMT in women. Similar levels of association were found for the English and arithmetic tests. After adjustment for a range of covariates including education, the size of effect was undiminished in men but increased in women. In the present study, higher childhood IQ scores were associated with a lower degree of atherosclerosis by middle-age. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  9. The Orgueil meteorite: 150 years of history

    Science.gov (United States)

    Gounelle, Matthieu; Zolensky, Michael E.

    2014-10-01

    The goal of this paper is to summarize 150 yr of history of a very special meteorite. The Orgueil meteorite fell near Montauban in southwestern France on May 14, 1864. The bolide, which was the size of the full Moon, was seen across Western France, and almost immediately made the news in local and Parisian newspapers. Within a few weeks of the fall, a great diversity of analyses were performed under the authority of Gabriel Auguste Daubrée, geology professor at the Paris Museum, and published in the Comptes Rendus de l'Académie des Sciences. The skilled scientists reported the presence of iron sulfides, hydrated silicates, and carbonates in Orgueil. They also characterized ammonium salts which are now gone, and observed sulfates being remobilized at the surface of the stone. They identified the high water and carbon contents, and noted similarities with the Alais meteorite, which had fallen in 1806, 300 km away. While Daubrée and his colleagues noted the similarity of the Orgueil organic matter with some terrestrial humus, they were cautious not to make a direct link with living organisms. One century later, Nagy and Claus were less prudent and announced the discovery of "organized" elements in some samples of Orgueil. Their observations were quickly discredited by Edward Anders and others who also discovered that some pollen grains were intentionally placed into the rock back in the 1860s. Orgueil is now one of the most studied meteorites, indeed one of the most studied rocks of any kind. Not only does it contain a large diversity of carbon-rich compounds, which help address the question of organo-synthesis in the early solar system but its chemical composition is also close to that of the Sun's photosphere and serves as a cosmic reference. Secondary minerals, which make up 99% of the volume of Orgueil, were probably formed during hydrothermal alteration on the parent-body within the first few million years of the solar system; their study is essential to our

  10. The centuries-old and thousand- year oscillations of uranium distribution in the Lake Baikal sediments, according to the neutron-fission (n,f)-autoradiography

    Science.gov (United States)

    Kirichenko, Ivan; Zhmodik, Sergey; Belyanin, Dmitriy; Khlistov, Oleg

    2016-04-01

    The trace elements local distribution data, particularly (U, P, Br, Mo, BiSi et. all) in a lake and oceans bottom sediments reflects the conditions of those sediments formation, and correlates with changes in paleoclimatic conditions. In papers [Colman et all, 1995; Goldberg et all, 2000, etc.] established that the concentrations of some elements contained in the bottom sediments of Lake Baikal, in particular BiSi, Sr / Ba, Sr / Rb, Ti, U et al., reflect changes in insolation caused by periodic oscillations parameters Earth's orbit (Milankovitch cycles). At the same time, a bottom sediments of the largest continental lake (Lake Baikal), can keep a record of changes less periodicity. Our research focuses on the study of the spatial distribution of uranium with high resolution in the bottom sediments of Lake Baikal. The purpose of this research is determination the centure-old and thousand- old year oscillations in the concentration of uranium in the sediments of Lake Baikal. Fragments of the lake sediment columns taken from the axial part of the Akademicheskiy Ridge in Lake Baikal (stations coordinates St -8 (53 32'15"N 107 56'25"E); - and St11 - (53 33'51"N 108 00'05"E) were studied using complex of local analysis methods, such as: n, f - and n, β-autoradiography, SEM. The distributions of uranium and phosphorus in the authigenic component of sediments along the whole columns length (with the resolution of 10 micron which corresponds to the time resolution of about six months) have been studied by the autoradiography method. Statistical data analysis (Fourier and wavelet analysis) were used for detection oscillations in the uranium concentration Three main different factors of concentrators were established for uranium and phosphorus in the sediments of the Academic mountain range:1) sedimentation, 2) nutrient,3) diagenetic. The periodicity (range from 100 to 1,000 years), in the distribution of authigenic uranium in the sediment column were identified by

  11. The impact of low and intermediate-level radioactive waste on humans and the environment over the next one hundred thousand years.

    Science.gov (United States)

    Kautsky, Ulrik; Saetre, Peter; Berglund, Sten; Jaeschke, Ben; Nordén, Sara; Brandefelt, Jenny; Keesmann, Sven; Näslund, Jens-Ove; Andersson, Eva

    2016-01-01

    In order to assess the potential radiological risk to humans and the environment from a geological repository for radioactive waste, a safety assessment must be performed. This implies that the release and transfer of radionuclides from the repository into the surface environment are calculated and that the effects in the biosphere are evaluated for an assessment period up to one hundred thousand years according to Swedish regulations. This paper discusses the challenges associated with the modelling of surface ecosystems over such long time scales, using the recently completed assessment for the extension of the existing repository for the low- and intermediate-level nuclear waste (called SFR) in Forsmark, Sweden as an applied example. In the assessment, natural variation and uncertainties in climate during the assessment period were captured by using a set of climate cases, primarily reflecting different expectations on the effects of global warming. Development of the landscape at the site, due to post-glacial isostatic rebound, was modelled, and areas where modelling indicated that radionuclides could discharge into the biosphere were identified. Transfers of surface water and groundwater were described with spatially distributed hydrological models. The projected release of radionuclides from the bedrock was then fed into a biosphere radionuclide transport model, simulating the transport and fate of radionuclides within and between ecosystems in the landscape. Annual doses for human inhabitants were calculated by combining activity concentrations in environmental media (soil, water, air and plants) with assumptions on habits and land-use of future human inhabitants. Similarly, dose rates to representative organisms of non-human biota were calculated from activity concentrations in relevant habitats, following the ERICA methodology. In the main scenario, the calculated risk for humans did not exceed the risk criteria or the screening dose rate for non

  12. 40 CFR 68.168 - Five-year accident history.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Five-year accident history. 68.168 Section 68.168 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.168 Five-year accident history...

  13. History, Archaeology and the Bible Forty Years after "Historicity"

    DEFF Research Database (Denmark)

    In History, Archaeology and the Bible Forty Years after “Historicity”, Hjelm and Thompson argue that a ‘crisis’ broke in the 1970s, when several new studies of biblical history and archaeology were published, questioning the historical-critical method of biblical scholarship. The crisis formed...... articles from some of the field’s best scholars with comprehensive discussion of historical, archaeological, anthropological, cultural and literary approaches to the Hebrew Bible and Palestine’s history. The essays question: “How does biblical history relate to the archaeological history of Israel...

  14. The Antarctic ice core chronology (AICC2012: an optimized multi-parameter and multi-site dating approach for the last 120 thousand years

    Directory of Open Access Journals (Sweden)

    D. Veres

    2013-08-01

    Full Text Available The deep polar ice cores provide reference records commonly employed in global correlation of past climate events. However, temporal divergences reaching up to several thousand years (ka exist between ice cores over the last climatic cycle. In this context, we are hereby introducing the Antarctic Ice Core Chronology 2012 (AICC2012, a new and coherent timescale developed for four Antarctic ice cores, namely Vostok, EPICA Dome C (EDC, EPICA Dronning Maud Land (EDML and Talos Dome (TALDICE, alongside the Greenlandic NGRIP record. The AICC2012 timescale has been constructed using the Bayesian tool Datice (Lemieux-Dudon et al., 2010 that combines glaciological inputs and data constraints, including a wide range of relative and absolute gas and ice stratigraphic markers. We focus here on the last 120 ka, whereas the companion paper by Bazin et al. (2013 focuses on the interval 120–800 ka. Compared to previous timescales, AICC2012 presents an improved timing for the last glacial inception, respecting the glaciological constraints of all analyzed records. Moreover, with the addition of numerous new stratigraphic markers and improved calculation of the lock-in depth (LID based on δ15N data employed as the Datice background scenario, the AICC2012 presents a slightly improved timing for the bipolar sequence of events over Marine Isotope Stage 3 associated with the seesaw mechanism, with maximum differences of about 600 yr with respect to the previous Datice-derived chronology of Lemieux-Dudon et al. (2010, hereafter denoted LD2010. Our improved scenario confirms the regional differences for the millennial scale variability over the last glacial period: while the EDC isotopic record (events of triangular shape displays peaks roughly at the same time as the NGRIP abrupt isotopic increases, the EDML isotopic record (events characterized by broader peaks or even extended periods of high isotope values reached the isotopic maximum several centuries before

  15. The history of Korean Institute Chemical Engineers for fifteen years

    International Nuclear Information System (INIS)

    2012-12-01

    This book reports the history of Korean Institute of Chemical Engineers with commemorative message, three congratulatory address and photos for fifty years. Nest, it consists of five chapters, which deals with development this institute by chronological classification. It reports the development history by activity such as education, research, publishing branch, international activity, data, woman, and executive office. It records challenge of chemical engineering, remembrance for past presidents and appendixes on history and a list of members.

  16. A brief 100 year history of carbon.

    Science.gov (United States)

    Kemp, Terence J

    2017-09-01

    Elemental carbon has been known from time immemorial in its forms of diamond and graphite, while the Industrial Revolution was powered by coal. The molecular structures of diamond and graphite were established following the inception of X-ray crystallography while the complex natures of charcoal and coal have been investigated for 100 years. Recent developments in activated charcoal are described in an article in this issue of Science Progress. However, no-one could have guessed that carbon would have presented such structural surprises as those of C60 fullerene, carbon nanotubes, and graphene. Materials science has benefited from the discovery of carbon fibres, and our understanding of the spectroscopy and bonding in the simplest carbon molecule, C2, has reached new depths.

  17. Uroradiology in 117 year history of radiology

    International Nuclear Information System (INIS)

    Naumov, N.

    2013-01-01

    Full text: Introduction: ‘In order to understand the present and see the future, you must know the past'. This motto, used by Professor Jean-Franois Moreau in his presentation ‘A Century uroradiology in Europe 1896 -1996’, is the occasion, with his consent and participation to complement the presentation not only with what comes as a change in our profession in recent years, but also to celebrate milestones in the development of uroradiology in Bulgaria. One of the major health problems in Europe, not only in the late 19th century, but today is renal calculi. For this reason, five months after the described by Wilhelm Conrad Roentgen X- rays attempts to use them in medical practice by urologists namely in seeking opportunities to demonstrate calculi began. What you will learn: This justifies the first phase, covering 1896-1929, has not only uroradiology but of radiology as a whole, in which it is a hobby of the urologists. Summarizing the main points as in the technical development of radiological equipment, but above all the introduction of diagnostic methods, some of which have not lost their relevance and today, this period naturally ends with one of the most epochal discoveries in medicine and first diagnostic method combining morphological with functional diagnostics - excretory urography . The second step, covering the period of 1929-1960, is characterized by increasing further improvement of the equipment, but also of the applied diagnostic methods, as the urologist is still leading in applying these methods, but now with the technical assistance of the radiologist. After World War II, this approach began to change, besides the appearance of chapters on uroradiology in major guidelines in diagnostic radiology, new methods have been developed, and including vascular contrast diagnostic are made and implemented by radiologists. The third stage, cover the period 1960-1980, entitled ‘Fathers of uroradiology’ account entry of CT low-osmolar nonionic

  18. Synthetic detergents: 100 years of history.

    Science.gov (United States)

    Kogawa, Ana Carolina; Cernic, Beatriz Gamberini; do Couto, Leandro Giovanni Domingos; Salgado, Hérida Regina Nunes

    2017-09-01

    In the year 2016 the synthetic detergents complete 100 years and in this story they evolved as cleaners. They are already part of the routine of thousands of people worldwide. For a higher power of cleaning of the detergent, today, are added phosphates, the main responsible for environmental problems. After 100 years of synthetic detergents, the effect of the combination of various cleaners on the environment is a gap. Legislation and guidelines about the other components of the formula of cleaners still missing. Even the term biodegradable can be best placed on the diversity of products currently entitled biodegradable. A lot attitudes can still be taken to continuously improve the relationship between the parties involved, animals, plants, waters and men, so that in another 100 years continues to exist this interaction with the environment without destroying it. The marketing used by synthetic detergent companies evolved a lot over the years and showed maturity to deal with changes in theories and strategies for promotion and even with the constant social reform that its consumer lived, accompanying them intelligently to be able to capture their changing needs and desires, and so assemble the best way to connect to them. This paper focuses on the subject synthetic detergents as well as (i) types and applications, (ii) threats, (iii) sustainability, (iv) legislation, (v) packaging and (vi) marketing strategies.

  19. Fifty years of IAA History Symposia (1967-2016)

    Science.gov (United States)

    Skoog, A. Ingemar; Hall, R. Cargill

    2017-05-01

    The International Academy of Astronautics (IAA) Symposia on the History of Rocketry and Astronautics have been held annually at the International Astronautical Congresses since 1967. During these past 50 years nearly 800 papers have been presented and subsequently published in the proceedings. With a 20-year rule imposed for historical presentations, the first 10 symposia concentrated on pre-World War II and early 1950s activities. A surprisingly large number of papers on early, less well-known Soviet-Russian contributions to rocketry and astronautics were presented in the first symposia, despite the ongoing Space Race between the U.S and USSR. Another important element in these symposia involved memoir papers offered by pre- and post-war rocket and astronautics pioneers from many countries, and the participation of many of these pioneers in person. In sum, the history of national space and rocket projects from some 40 countries were presented over the years in IAA History Symposia. These 50 symposia have provided a platform for scholars and professional and non-professional historians to meet and discuss the history of rocketry and astronautics, and to personally interview many space pioneers, most of whom today are deceased. Their personal recollections have since been shared with a large audience. Over time, IAA history papers divided into recognizable periods: ancient times through the 19th century, and the 20th and 21st centuries, which separate among actions and events that took place before 1945, in 1945 to 1957, and after 1957 (which marked the beginning of the space age). Proceedings of the IAA History Symposia have been published in English, ultimately in the History Series of the American Astronautical Society (AAS) and its publishing arm, Univelt Inc., under an agreement secured with the IAA. This paper presents an overview of the IAA History Symposia. It examines the early years of the history committee and its first symposium, the evolution of

  20. A History of the Rhodesian Stock Exchange: The Formative Years ...

    African Journals Online (AJOL)

    or Register. DOWNLOAD FULL TEXT Open Access DOWNLOAD FULL TEXT Subscription or Fee Access. A History of the Rhodesian Stock Exchange: The Formative Years, 1946-1952. George Karekwaivenani. Abstract. No Abstract Available Zambezia (2003), XXX (i): 9-34. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT

  1. Brain Science and Teaching: A Forty-Year Personal History

    Science.gov (United States)

    Kirby, Linda Faye

    2016-01-01

    This paper is the sharing of a record, the personal history of an educator pursuing an interest in knowledge of the brain. Over the years, this fascination sparked the idea to create a course for teachers based on brain science, with a twist. Certain course assignments would require teachers to interpret knowledge of the brain in the context of…

  2. The Littlest Historians: Early Years Programming in History Museums

    Science.gov (United States)

    Leftwich, Mariruth; Haywood, Clare

    2016-01-01

    Working with children under five years old and the adults that accompany them is a rapidly growing area within the museum and wider cultural sector, with important emphasis being placed on early learning in both the United Kingdom and United States. For history museums in particular, early learning offers a unique set of questions and challenges,…

  3. Breaking the 20 Year Rule: Very Modern History at GCSSE

    Science.gov (United States)

    Culpin, Chris

    2005-01-01

    History is the study of the past; some of the past is more recent than a glance over many schemes of work might lead us to think. Chris Culpin makes the case for ignoring the 20 year rule and tackling head on--and, crucially, "historically"--the big issues of the very recent past. He shows that critical historical study is precisely what…

  4. Exploring 350 Years of Jewish American History on the Internet

    Science.gov (United States)

    Berson, Michael J.; Cruz, Barbara C.

    2005-01-01

    The recent Library of Congress exhibition, From Haven to Home: 350 Years of Jewish Life in America, has sparked renewed interest in the history of Jews in the United States. The collection featured more than 200 documents, images, and artifacts that chronicle the Jewish American experience. In exhibit from September through December 2004, From…

  5. Four thousand years of atmospheric Pb, Cd and Zn deposition recorded by the ombrotrophic peat bog of Penido Vello (northwestern Spain)

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Cortizas, A.; Pontevedra-Pombal, X.; Novoa-Munoz, J.C.; Garcia-Rodeja, E. [Universidad de Santiago de Compostila, Santiago de Compostela (Spain). Dept. de Edafologia y Quimica Agricola

    1997-12-01

    The Northwest Iberian Peninsula is a mid-latitude oceanic region with areas where different types of bogs are frequent or abundant. The ombrotrophic nature of some bogs make them suitable for the study of accumulation patterns of heavy metals. One of these bogs, Penido Vello, was sampled to a depth of 2.5 m and analyzed in detail for its physico-chemical properties and Pb, Zn and Cd concentrations. Ash and organic carbon content, Ca/Mg molar ratios and a number of other characteristics support an ombrotrophic interpretation of the core. Concentrations of Pb, Zn and Cd were measured, showing important variations in the core. While Zn and Cd are concentrated mainly in the upper sections of the core with minor changes with depth, the Pb profile shows significant peaks in the deeper layers suggesting pre-industrial atmospheric pollution. Enrichment factors (EFs) calculated by normalising to Al correlated well with those calculated by normalising to Ti. Maximum EFs are 33.56 and 52 for Pb, Zn and Cd respectively. While for Pb these values are comparable to those obtained by other authors, maximum Zn EFs are greater than those mentioned in the literature and may be attributed to the emissions of a nearby coal-burning power plant. At least for Pb the accumulation pattern suggests that atmospheric pollution can be dated back some 2800 years, and that pollution increased steadily since the Iron Age to reach considerably elevated levels, up to 5 times the `background`, during the Roman Empire. Changes in Pb emissions through times are in good accord with the prehistorical and historical record of the Iberian Peninsula. 54 refs., 8 figs., 1 tab.

  6. 50-year-old history of the Korean physical society

    International Nuclear Information System (INIS)

    2002-12-01

    This book introduces the root of Korean physics, the dawning of Korean physics, foundation and childhood of Korean physics society, growth of Korean physics society, revival of Korean physics society, corporation Korean physics society, leap of Korean physics society and challenges towards future. It also deals with 50-year-old history of the Korean physical society according to committees, special interest groups, branches in cities and provinces, branches in universities, laboratories, society bureau, and commemoration business to celebrate 50th anniversary.

  7. Carbon prices for the next thousand years

    Energy Technology Data Exchange (ETDEWEB)

    Gerlagh, Reyer [Tilburg Univ. (Netherlands). Dept. of Economics; Liski, Matti [Aalto Univ., Helsinki (Finland). School of Economics

    2012-06-15

    Climate is a persistent asset, bar none: changes in climate-related stocks have consequences spanning over centuries or possibly millennia to the future. To reconcile the discounting of such far-distant impacts and realism of the shorter-term decisions, we consider hyperbolic time-preferences in a climate-economy model. Time-changing utility discount rates have unexplored general-equilibrium effects: carbon prices exceed the pure carbon externality costs - the Pigouvian tax level - by multiple factors in our quantitative assessment. The climateeconomy model is rich in details but can be solved in closed-form yielding Markov carbon prices dependent on climate system parameters, damage estimates, technology parameters, and both short- and long-term time preferences. The equilibrium time discount rate is endogenous, and it can justify high carbon taxes as advocated by Stern while maintaining the realism of the macroeconomic outcome, thus providing a solution for the dilemma centering the carbon tax-discount rate debate. The welfare ranking of the policy alternatives is unambiguous: enforcing the Pigouvian tax decreases a consistently-defined welfare measure vis-a-vis the Markov equilibrium.

  8. Total Hip Arthroplasty – over 100 years of operative history

    Directory of Open Access Journals (Sweden)

    Stephen Richard Knight

    2011-11-01

    Full Text Available Total hip arthroplasty (THA has completely revolutionised the nature in which the arthritic hip is treated, and is considered to be one of the most successful orthopaedic interventions of its generation (1. With over 100 years of operative history, this review examines the progression of the operation from its origins, together with highlighting the materials and techniques that have contributed to its development. Knowledge of its history contributes to a greater understanding of THA, such as the reasons behind selection of prosthetic materials in certain patient groups, while demonstrating the importance of critically analyzing research to continually determine best operative practice. Finally, we describe current areas of research being undertaken to further advance techniques and improve outcomes.

  9. A two-billion-year history for the lunar dynamo.

    Science.gov (United States)

    Tikoo, Sonia M; Weiss, Benjamin P; Shuster, David L; Suavet, Clément; Wang, Huapei; Grove, Timothy L

    2017-08-01

    Magnetic studies of lunar rocks indicate that the Moon generated a core dynamo with surface field intensities of ~20 to 110 μT between at least 4.25 and 3.56 billion years ago (Ga). The field subsequently declined to <~4 μT by 3.19 Ga, but it has been unclear whether the dynamo had terminated by this time or just greatly weakened in intensity. We present analyses that demonstrate that the melt glass matrix of a young regolith breccia was magnetized in a ~5 ± 2 μT dynamo field at ~1 to ~2.5 Ga. These data extend the known lifetime of the lunar dynamo by at least 1 billion years. Such a protracted history requires an extraordinarily long-lived power source like core crystallization or precession. No single dynamo mechanism proposed thus far can explain the strong fields inferred for the period before 3.56 Ga while also allowing the dynamo to persist in such a weakened state beyond ~2.5 Ga. Therefore, our results suggest that the dynamo was powered by at least two distinct mechanisms operating during early and late lunar history.

  10. History, Archaeology and the Bible Forty Years after "Historicity"

    DEFF Research Database (Denmark)

    the discourse of the Copenhagen school’s challenge of standing positions, which—together with new achievements in archaeological research—demand that the regional history of ancient Israel, Judaea and Palestine be reconsidered in all its detail. This volume examines the major changes that have taken place...... articles from some of the field’s best scholars with comprehensive discussion of historical, archaeological, anthropological, cultural and literary approaches to the Hebrew Bible and Palestine’s history. The essays question: “How does biblical history relate to the archaeological history of Israel...... and Palestine?” and “Can we view the history of the region independently of a biblical perspective?” by looking at the problem from alternative angles and questioning long-held interpretations....

  11. Thousands of kilometres to visit CERN

    CERN Multimedia

    2003-01-01

    Students from the Columbus high school in the state of Mississippi with their physics teacher Ken Wester (left at rear) and Michel Della Negra, CMS spokesman (in front).An American school at CERN ? Unusual, to say the least... Yet 15 students from the class of Ken Wester, physics teacher in the Columbus High School, Mississippi, didn't hesitate to travel thousands of kilometres to come to CERN. Ken Wester participated last year in CERN's High School Teacher programme. Enthralled by his visit, he has organised the trip for his final year students to visit CERN. The 18-year-olds arrived on the 10th March and spent two days at the laboratory, visiting the CMS construction site and the AD antimatter factory, before leaving on a tour of Switzerland and Germany.

  12. Modern history of weather service for one hundred years

    International Nuclear Information System (INIS)

    2004-07-01

    This book describes meteorological history of Korea for a century. It consists of eleven chapters, which deals with the ancient history of meteorologic services, the beginning of modem history of meteorologic services from 1894 to 1910, meteorologic services in Japanese colonial era, meteorologic services in the U. S Military Government in Korea from 1945 to 1948, transition period from 1948 to 1950, Korean war period from 1950 to 1953, foundation construction period from 1953 to 1960, growth period in 1970s'. period of development in 1980s' foundation construction period for advanced technologies of meteorologic services in 1990s' and leaping period of meteorologic services in 2000s'.

  13. Brighter than a thousand suns

    International Nuclear Information System (INIS)

    Jungk, Robert

    2016-01-01

    This fascinating tangible report applies to all, who live face to face with the greatest danger of the 20th century. It describes the history of the atomic bomb as ''a history of real men'', who were in the summer 1939 yet able to prevent the construction of atomic bombs and the opportunity pass unused: They were moralically and politically out of touch with the threatening new invention. Jungk spreads an overwhelming material, opens up hitherto inaccessible sources, and explains in exciting way the dilemma of famous scientists, who fluctuate between the urge to research and moral distress. What has begun in the the twenties as collegial team work of young scientists, developed to a tragedy. Researchers, who felt committed alone to the scientific progress, saw very soon torn into the tension of power politics, and many of them begun to recognize that they have, how the American atomic physicists Oppenheimer expresses himself, done ''the work of the devil''. Despite sharp attacks Jungk is no moral damnation judgement. He wants to know his book understood as contribution to the large conversation, ''which may perhaps prepare a future without fear''.

  14. History of Korean Chemical Society for 50 years

    International Nuclear Information System (INIS)

    1999-05-01

    This book records the history of Korean Chemical Society from 1946 to 1996, which is divided into five chapters. The first chapter breaks the history into periodic characteristics. The second chapter introduces committee and executive office like chemical education committee and international cooperation committee. The third chapter lists the department of KCS such as departments of organic chemistry, inorganic chemistry, industrial chemistry, biochemistry and physical chemistry. The fourth chapter reports each branch of KCS. The last chapter has a chronological table and articles of association and organizations.

  15. Toward a 530,000-year Hydroclimate History for the Southern Half of the Australasian Monsoon

    Science.gov (United States)

    Gagan, M. K.; Scroxton, N. G.; Kimbrough, A. K.; Krause, C.; Hantoro, W. S.; Ayliffe, L. K.; Dunbar, G. B.; Cheng, H.; Edwards, R. L.; Hellstrom, J. C.; Shen, C. C.; Scott-Gagan, H.; Suwargadi, B. W.; Rifai, H.

    2015-12-01

    Speleothem 18O/16O records have revealed key aspects of past hydroclimates in the northern Australasian monsoon domain on orbital to millennial scales, but much less is known about the southern half of the monsoon system. We aim to develop a hydroclimate history for the southern Australasian monsoon based on speleothems from southwest Sulawesi and Flores, Indonesia (latitudes 5-9oS), which extend back to ~530 kyr BP and 90 kyr BP, respectively. To date, the 18O/16O record for Sulawesi covers glacial terminations TIV (~340 kyr BP), TIII (~245 kyr BP) and TI (~18 kyr BP). The details of each termination are different, however two important hydroclimate patterns are emerging. First, the 18O/16O record shows sharp weakening of the monsoon immediately before each termination. This surprisingly robust pattern marks a southern extension of the northern 'weak monsoon interval', and reinforces the idea that southward monsoon displacement is a fundamental feature of terminations. Second, monsoon intensification around Sulawesi lags the rise in atmospheric CO2 and Antarctic temperature by several thousand years, but parallels the 18O/16O decrease in atmospheric O2. Our finding extends that of Wang et al. (2008) and Cheng et al. (2009) who noted the influence of the low-latitude hydrological cycle on the 18O/16O of tropical transpiration, and its potential for correlating ice core and paleomonsoon records. Further south, the 90-kyr 18O/16O record for Flores shows clear precession-scale antiphasing with China, and southerly positioning of the summer monsoon rainfall belt during Heinrich stadials. Heinrich stadials 5, 4, 2 and 1 occur during wetter intervals in Flores that accompanied relatively high southern summer insolation. Intriguingly, these events are associated with abrupt atmospheric CH4 signals that may be due to increased Southern Hemisphere CH4 production related to intensification of monsoon rainfall over southern tropical land areas (Rhodes et al., 2014).

  16. The Early Years of Organized Chiropractic Orthopedics, 1954–1973: A Social History

    Science.gov (United States)

    Green, Bart N.; Johnson, Claire D.

    2009-01-01

    Objective: This paper presents the origins and development of the organized chiropractic orthopedics movement in the United States from 1954–1973. Methods: Hand searches of early periodicals were performed and information was organized chronologically to create a timeline. Context for the timeline was provided by extracting pertinent information from audio recordings of interviews. Relevant background information was located using the cumulative index of the journal Chiropractic History and searching the MANTIS database. Historical Features: After World War I, The advent of third party reimbursement for health care created a new environment for health care practitioners. For doctors of chiropractic, this event provided the impetus to begin the postgraduate chiropractic orthopedics program over 50 years ago. In 1954, Alvin A. Hancock, DC and F. Maynard Lipe, DC successfully launched an active orthopedics movement after several earlier attempts failed during the 1940s and early 1950s. The movement generated from the desire to train and certify chiropractors to manage personal injury and workers’ compensation low back injuries. In addition to developing interdisciplinary educational programs, the chiropractic orthopedics group was responsible for producing a research agenda, some of the profession’s early orthopedic-focused research, and for starting the National Council on Chiropractic Orthopedics of the National Chiropractic Association, which later became the American Chiropractic Association Council on Orthopedics. These organizations produced thousands of specialists in chiropractic orthopedics, later known as Diplomates of the American Board of Chiropractic Orthopedists. Conclusion: Several orthopedics interest groups were formed and credentialing processes were created to qualify doctors as recognized chiropractic orthopedics specialists. The popularity of this movement resulted in the inclusion of orthopedics into core chiropractic college curricula and

  17. 195-Year History of Mykolayiv Observatory: Events and People

    Directory of Open Access Journals (Sweden)

    Shulga, O.V.

    2017-01-01

    Full Text Available The basic stages of the history of the Mykolaiv Astronomical Observatory are shown. The main results of the Observatory activities are presented by the catalogs of star positions, major and minor planets in the Solar system, space objects in the Earth orbit. The information on the qualitative and quantitative structure of the Observatory, cooperation with the observatories of Ukraine and foreign countries as well as major projects carried out in the Observatory is provided.

  18. [A 43-year-old woman with 18 years history of parkinsonism].

    Science.gov (United States)

    Sugita, Y; Yokochi, M; Ida, A; Mori, H; Shirai, T; Imai, H; Mizuno, Y

    1996-10-01

    We report a 43-year-old woman who died after 18 years history of parkinsonism. She was well until 25 years of the age (1976) when she noted a difficulty in stepping her feet. In the next year, she started to drag her feet. She was treated with levodopa with good response, however, she developed dyskinesia when she was 33 years of the age. She was evaluated in another hospital in 1984. She showed normal intelligence, normal ocular movement, masked face, small voice, small step gait, stooped posture, freezing of the gait, retropulsion, and cogwheel rigidity in limbs. No tremor or ataxia was noted. She received left ventrolateral thalamotomy at that time. Rigidity on the right side markedly reduced, however, she continued to show bradykinesia and motor fluctuations. On August 1 of 1994, she developed fever of 40 degrees C and dyspnea. On the next day, she expired from acute respiratory distress. She was able to walk unsupported until just before her last admission. The patient was discussed in a neurological CPC. The chief discussant arrived at the conclusion that this patient had Lewy body-positive young onset Parkinson's disease. Opinions were divided into two groups, i.e., young onset Lewy-body positive Parkinson's disease and Lewy-body negative young onset parkinsonism. Post-mortem examination revealed moderate loss of pigmented neurons in the substantia nigra more in the ventro-lateral part. Lewy bodies were found in the remaining neurons. Lewy bodies were more frequently seen in the locus coeruleus, although neuronal loss was less prominent in the locus coeruleus. The dorsal vagal motor nucleus showed moderate loss of neurons. Otherwise, the central nervous system was unremarkable. To our knowledge, this patient had the second youngest age of the onset so far reported in the literature for Lewy-body positive typical Parkinson's disease.

  19. Concluding remarks: Reflections on the forty year's history of TNF

    International Nuclear Information System (INIS)

    Martin, L.W.

    1994-01-01

    The History of NATO's TNF policy is much wider than it may first appear, for NATO TNF policy has been the heart of the whole nuclear question since shortly after it was first so dramatically posed in 1945. Admittedly the ultimate foundation of deterrence has been the overarching balance of strategic nuclear weapons between the two Superpowers. These have provided the strategic open-quotes monitorclose quotes of ultimately unacceptable damage that inspires cautious behavior at lower levels of conflict. But if the strategic weapons inculcate the caution, it has been with TNF that the opposing blocs have chiefly tried to harness nuclear weapons to particular situations and manipulate them to their advantage. The key characteristic of nuclear weapons that distinguishes them from all others is their virtually unlimited destructive potential. Powers disposing of large strategic nuclear forces cannot readily, perhaps ever, be deprived of an ultimate capacity to do outrageous harm. If they are to be defeated, it must therefore be by outmaneuvering them so that they yield the essential prizes without recourse to their worst possibilities. If nuclear weapons are to be used in this process, whether actually or by latent influence on particular issues, it must be in some limited form. NATO's TNF policy constitutes the best example of this so far in nuclear history

  20. Understanding World Economic History

    Science.gov (United States)

    Whaples, Robert

    2013-01-01

    One joy of studying history is discovering people living meaningful lives and behaving in unusual ways that are startling to the modern reader--young or old. Why did pre-modern people living hundreds or even thousands of years ago do things so differently than we do? Robert Whaples states that Economic historians conclude that the key difference…

  1. 5000 years of geometry mathematics in history and culture

    CERN Document Server

    Scriba, Christoph J

    2015-01-01

    The present volume provides a fascinating overview of geometrical ideas and perceptions from the earliest cultures to the mathematical and artistic concepts of the 20th century. It is the English translation of the 3rd edition of the well-received German book “5000 Jahre Geometrie,” in which geometry is presented as a chain of developments in cultural history and their interaction with architecture, the visual arts, philosophy, science, and engineering. Geometry originated in the ancient cultures along the Indus and Nile Rivers and in Mesopotamia, experiencing its first “Golden Age” in Ancient Greece. Inspired by the Greek mathematics, a new germ of geometry blossomed in the Islamic civilizations. Through the Oriental influence on Spain, this knowledge later spread to Western Europe. Here, as part of the medieval Quadrivium, the understanding of geometry was deepened, leading to a revival during the Renaissance. Together with parallel achievements in India, China, Japan and the ancient American cultur...

  2. Bismarck in the Bush: Year 12 Write Zambia's History for Zambian Students

    Science.gov (United States)

    Gray, Peter

    2011-01-01

    Peter Gray explains how his Year 12 students came to research and write a resource on the history of Zambia, for history teachers "in" Zambia. The construction of the resource stretched the Year 12 students in new ways: the Internet was useless and there were no easy digests in A-Level textbooks to get them started. They would have to…

  3. Forty years of solitude: life-history divergence and behavioural isolation between laboratory lines of Drosophila melanogaster.

    Science.gov (United States)

    Boake, C R B; McDonald, K; Maitra, S; Ganguly, R

    2003-01-01

    The study of the early stages of speciation can benefit from examination of differences between populations of known history that have been separated for a short time, such as a few thousands of generations. We asked whether two lines of Drosophila melanogaster that were isolated more than 40 years ago have evolved differences in life-history characters, or have begun to evolve behavioural or postzygotic isolation. One line, which is resistant to DDT, showed lower egg production and a shorter lifespan than a susceptible line. These differences are not a pleiotropic effect of resistance because they are not attributable to the chromosome that contains the resistance factors. The two lines have begun to become behaviourally isolated. Again, the isolation is not attributable to genes on the chromosome that contains resistance factors. The lines show only prezygotic isolation; there is no evidence of reduced fitness of F1 or F2 hybrids. These lines and others like them, should be excellent subjects for analyses of genetic changes that could lead to speciation.

  4. Fifty years of CERN history in the spotlight

    CERN Document Server

    2004-01-01

    The programme of events for CERN's Golden Jubilee year was officially unveiled at a press conference on 8 March. The first of these events took place the following day, when the Swiss commemorative postage stamp issued in the Laboratory's honour went on sale in post offices throughout Switzerland.

  5. A case of astrocytoma, 19 year history after BNCT

    International Nuclear Information System (INIS)

    Kamano, Shuji

    2006-01-01

    A 39-year-old man had received Boron Neutron Capture Therapy (BNCT) in 1987 for a Grade II Astrocytoma. He gradually exacerbated and received a second operation in 1994. The mass taken in the second operation is almost competent with radiation necrosis. Following that, he shows no signs of recurrence. Currently, he has returned to full time employment in physical labor. This case suggests effectiveness of BNCT for rather low-grade astrocytomas. (author)

  6. Reciis 8 years: A history of innovation and challenges

    OpenAIRE

    Trigueiros, Umberto

    2015-01-01

    With the edition of this volume 9, paragraph 2, the Electronic Journal of Communication, Information & Innovation in Health - Reciis - complete eight years of foundation this June 2015. One of the most scientific journals young Fiocruz, the publication of the Institute of Communication and Scientific and Technological Information in Health - Icict - celebrates its eighth anniversary in a position of continued consolidation of its innovative editorial design and growing academic recognitio...

  7. Exploring Medieval European Society with Chess: An Engaging Activity for the World History Classroom

    Science.gov (United States)

    Pagnotti, John; Russell, William B., III

    2012-01-01

    In a typical high school World History course, the teacher must teach thousands of years of human history in one year, thus making it the most comprehensive history course offered in school. Given the extended content requirements in a World History course, individual topics are given little time before the class must "move on" to the…

  8. 60 years of UJV Rez - a look back at the history of nuclear energy

    International Nuclear Information System (INIS)

    Vercak, Vladimir

    2015-01-01

    The 60-year history of the Institute is outlined. The concluding section shows the current potential of the UJV Rez. a. s. company (and the UJV Group) as the successor to the former state-owned Nuclear Research Institute. (orig.)

  9. History of Publications from the American Otological Society: A Celebration of the 150-Year History of the American Otological Society.

    Science.gov (United States)

    Lustig, Lawrence R

    2018-04-01

    : The American Otological Society (AOS) has been on the forefront of advancing the science of auditory and vestibular physiology, and art of ear medicine since its founding in 1868. For 150 years, through its publications, the AOS has provided a critical forum to debate these advances, highlighting treatment successes and failures, and served a place to celebrate its history. This historical review provides an overview of the publications of the AOS since its founding: the Transactions of the annual meeting from 1868 through 2006, Treatises on Otosclerosis (1928-1935), the History of the Society from the 100 and 125th anniversary, and the sponsored Society journals-American Journal of Otology (1879-1883, 1979-2000) and Otology & Neurotology (2001-present).

  10. L'etat, c'est moi. Fifty years of history and philosophy of evolutionary biology.

    Science.gov (United States)

    Ruse, Michael

    2016-01-01

    I reflect on my fifty-year history as a philosopher of biology, showing how it has taken me from rather narrow analytic studies, through the history of ideas, and now on to issues to do with science and religion. I argue that moral concerns were and still are a major motivation behind what I do and write. Copyright: © 2016 by Fabrizio Serra editore, Pisa · Roma.

  11. What history tells us VII. Twenty-five years ago: the production of ...

    Indian Academy of Sciences (India)

    2006-11-13

    Nov 13, 2006 ... Home; Journals; Journal of Biosciences; Volume 31; Issue 5. What history tells us VII. Twenty-five years ago: the production of mouse embryonic stem cells. Michel Morange. Series Volume 31 Issue 5 December 2006 pp 537-541. Fulltext. Click here to view fulltext PDF. Permanent link:

  12. Screening history of women with cervical cancer: a 6-year study in Aarhus, Denmark.

    Science.gov (United States)

    Ingemann-Hansen, O; Lidang, M; Niemann, I; Dinesen, J; Baandrup, U; Svanholm, H; Petersen, Lk

    2008-04-08

    To identify possible weaknesses in cervical screening in Aarhus County, 10 years after the programme was introduced, screening histories were examined. A major problem for the screening programme was that 31% of women were never screened and 61% under-screened, the latter group being significantly dominated by older women and high-stage tumours.

  13. History as a Foreign Language: Can We Teach Year 11 Pupils to Write with Flair?

    Science.gov (United States)

    Simmonds, Claire

    2016-01-01

    Disappointed that the use of the "PEEL" writing scaffold had led her Year 11 students to write some rather dreary essays, Claire Simmonds reflected that a lack of specific training on historical writing might be to blame. Drawing on genre theory and the work of the history teaching community, Simmonds attempted to theorise the…

  14. History through First-Year Secondary School Spanish Textbooks: A Content Analysis

    Science.gov (United States)

    Holley-Kline, Sam

    2013-01-01

    Although enrollments in secondary school Spanish have risen over the past few decades, the Spanish-speaking world (Latin America, in particular) tends to be underrepresented or absent in history textbooks. Given that not all students who take entry-level Spanish classes will continue to more advanced levels, the first-year Spanish textbook may be…

  15. 500 years of Tantrasangraha-A Landmark in the History of Astronomy

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 4. 500 Years of Tantrasangraha – A Landmark in the History of Astronomy. B S Shylaja. Book Review Volume 8 Issue 4 April 2003 pp 66-68. Fulltext. Click here to view fulltext PDF. Permanent link:

  16. The natural history of levator avulsion one year following childbirth: a prospective study

    NARCIS (Netherlands)

    Delft, K. van; Thakar, R.; Sultan, A.H.; Hout, J. in't; Kluivers, K.B.

    2015-01-01

    OBJECTIVE: To explore the natural history of levator avulsion in primipara 1 year postpartum and correlate this to pelvic floor dysfunction (PFD). DESIGN: Observational longitudinal cohort study. SETTING: District General University Hospital. POPULATION OR SAMPLE: Nullipara at 36 weeks of gestation,

  17. 450 Years of Chicano History in Pictures/450 Anos del Pueblo Chicano.

    Science.gov (United States)

    Chicano Communications Center, Albuquerque, NM.

    For use with junior and senior high school students, this book presents more than 250 drawings and pictures, with an introduction and brief texts in English and Spanish, depicting 450 years of Chicano history. The book covers: Mexico before the Spanish Conquests, Spain's colonization of the Southwest, the United States war on Mexico, events in the…

  18. A Spectrum is Worth a Thousand Pictures

    Science.gov (United States)

    Gelderman, Richard F.

    2006-12-01

    A wise astronomer once pointed out that if a picture is worth a thousand words, then a spectrum is worth a thousand pictures. Unfortunately, spectra are rarely emphasized in the introductory astronomy courses and few students exit such a course with any meaningful understanding or appreciation of spectroscopy. Part of the problem is lack of background knowledge; the typical introductory astronomy student has little experience with spectroscopy or atomic physics. Another issue is that spectra are not pretty pictures and are not intuitively understandable. We present and discuss a series of “minds-on” exercises and activities built into a college-level “stars, galaxies, and cosmology” intro astronomy course. The lessons are structured to help students improve their ability to recognize patterns and improve their ability to really see the details in front of them. Another goal is for students to realize there is “more than meets the eye” to learn how to discover “hidden” diagnostics, such as different sources of light their eyes see as white light. A curriculum that emphasizes spectroscopy also provides the opportunity to stress the story of the “Harvard Women,” a tale that bridges gender gaps and often humanizes scientists in the eyes of non-science majors. Finally, with a solid foundation in spectroscopy, students are better prepared to understand exciting topics such as Hubble’s Law and the importance of primordial nucleosynthesis.

  19. Europe on fire three thousand years ago: Arson or climate?

    Science.gov (United States)

    Zennaro, Piero; Kehrwald, Natalie; Marlon, Jennifer; Ruddiman, William F.; Brücher, Tim; Agostinelli, Claudio; Dahl-Jensen, Dorthe; Zangrando, Roberta; Gambaro, Andrea; Barbante, Carlo

    2015-06-01

    The timing of initiation of human impacts on the global climate system is actively debated. Anthropogenic effects on the global climate system are evident since the Industrial Revolution, but humans may have altered biomass burning, and hence the climate system, for millennia. We use the specific biomarker levoglucosan to produce the first high-temporal resolution hemispheric reconstruction of Holocene fire emissions inferred from ice core analyses. Levoglucosan recorded in the Greenland North Greenland Eemian ice core significantly increases since the last glacial, resulting in a maximum around ~2.5 ka and then decreasing until the present. Here we demonstrate that global climate drivers fail to explain late Holocene biomass burning variations and that the levoglucosan maximum centered on ~2.5 ka may be due to anthropogenic land clearance.

  20. Smoking duration, respiratory symptoms, and COPD in adults aged ≥45 years with a smoking history

    Science.gov (United States)

    Liu, Yong; Pleasants, Roy A; Croft, Janet B; Wheaton, Anne G; Heidari, Khosrow; Malarcher, Ann M; Ohar, Jill A; Kraft, Monica; Mannino, David M; Strange, Charlie

    2015-01-01

    Background The purpose of this study was to assess the relationship of smoking duration with respiratory symptoms and history of chronic obstructive pulmonary disease (COPD) in the South Carolina Behavioral Risk Factor Surveillance System survey in 2012. Methods Data from 4,135 adults aged ≥45 years with a smoking history were analyzed using multivariable logistic regression that accounted for sex, age, race/ethnicity, education, and current smoking status, as well as the complex sampling design. Results The distribution of smoking duration ranged from 19.2% (1–9 years) to 36.2% (≥30 years). Among 1,454 respondents who had smoked for ≥30 years, 58.3% were current smokers, 25.0% had frequent productive cough, 11.2% had frequent shortness of breath, 16.7% strongly agreed that shortness of breath affected physical activity, and 25.6% had been diagnosed with COPD. Prevalence of COPD and each respiratory symptom was lower among former smokers who quit ≥10 years earlier compared with current smokers. Smoking duration had a linear relationship with COPD (Psmoking status and other covariates. While COPD prevalence increased with prolonged smoking duration in both men and women, women had a higher age-adjusted prevalence of COPD in the 1–9 years, 20–29 years, and ≥30 years duration periods. Conclusion These state population data confirm that prolonged tobacco use is associated with respiratory symptoms and COPD after controlling for current smoking behavior. PMID:26229460

  1. Smoking duration, respiratory symptoms, and COPD in adults aged ≥45 years with a smoking history.

    Science.gov (United States)

    Liu, Yong; Pleasants, Roy A; Croft, Janet B; Wheaton, Anne G; Heidari, Khosrow; Malarcher, Ann M; Ohar, Jill A; Kraft, Monica; Mannino, David M; Strange, Charlie

    2015-01-01

    The purpose of this study was to assess the relationship of smoking duration with respiratory symptoms and history of chronic obstructive pulmonary disease (COPD) in the South Carolina Behavioral Risk Factor Surveillance System survey in 2012. Data from 4,135 adults aged ≥45 years with a smoking history were analyzed using multivariable logistic regression that accounted for sex, age, race/ethnicity, education, and current smoking status, as well as the complex sampling design. The distribution of smoking duration ranged from 19.2% (1-9 years) to 36.2% (≥30 years). Among 1,454 respondents who had smoked for ≥30 years, 58.3% were current smokers, 25.0% had frequent productive cough, 11.2% had frequent shortness of breath, 16.7% strongly agreed that shortness of breath affected physical activity, and 25.6% had been diagnosed with COPD. Prevalence of COPD and each respiratory symptom was lower among former smokers who quit ≥10 years earlier compared with current smokers. Smoking duration had a linear relationship with COPD (Psmoking status and other covariates. While COPD prevalence increased with prolonged smoking duration in both men and women, women had a higher age-adjusted prevalence of COPD in the 1-9 years, 20-29 years, and ≥30 years duration periods. These state population data confirm that prolonged tobacco use is associated with respiratory symptoms and COPD after controlling for current smoking behavior.

  2. [History of viral hepatitis].

    Science.gov (United States)

    Fonseca, José Carlos Ferraz da

    2010-01-01

    The history of viral hepatitis goes back thousands of years and is a fascinating one. When humans were first infected by such agents, a natural repetitive cycle began, with the capacity to infect billions of humans, thus decimating the population and causing sequelae in thousands of lives. This article reviews the available scientific information on the history of viral hepatitis. All the information was obtained through extensive bibliographic review, including original and review articles and consultations on the internet. There are reports on outbreaks of jaundice epidemics in China 5,000 years ago and in Babylon more than 2,500 years ago. The catastrophic history of great jaundice epidemics and pandemics is well known and generally associated with major wars. In the American Civil War, 40,000 cases occurred among Union troops. In 1885, an outbreak of catarrhal jaundice affected 191 workers at the Bremen shipyard (Germany) after vaccination against smallpox. In 1942, 28,585 soldiers became infected with hepatitis after inoculation with the yellow fever vaccine. The number of cases of hepatitis during the Second World War was estimated to be 16 million. Only in the twentieth century were the main agents causing viral hepatitis identified. The hepatitis B virus was the first to be discovered. In this paper, through reviewing the history of major epidemics caused by hepatitis viruses and the history of discovery of these agents, singular peculiarities were revealed. Examples of this include the accidental or chance discovery of the hepatitis B and D viruses.

  3. Teaching Thousands with Cloud-based GIS

    Science.gov (United States)

    Gould, Michael; DiBiase, David; Beale, Linda

    2016-04-01

    Teaching Thousands with Cloud-based GIS Educators often draw a distinction between "teaching about GIS" and "teaching with GIS." Teaching about GIS involves helping students learn what GIS is, what it does, and how it works. On the other hand, teaching with GIS involves using the technology as a means to achieve education objectives in the sciences, social sciences, professional disciplines like engineering and planning, and even the humanities. The same distinction applies to CyberGIS. Understandably, early efforts to develop CyberGIS curricula and educational resources tend to be concerned primarily with CyberGIS itself. However, if CyberGIS becomes as functional, usable and scalable as it aspires to be, teaching with CyberGIS has the potential to enable large and diverse global audiences to perform spatial analysis using hosted data, mapping and analysis services all running in the cloud. Early examples of teaching tens of thousands of students across the globe with cloud-based GIS include the massive open online courses (MOOCs) offered by Penn State University and others, as well as the series of MOOCs more recently developed and offered by Esri. In each case, ArcGIS Online was used to help students achieve educational objectives in subjects like business, geodesign, geospatial intelligence, and spatial analysis, as well as mapping. Feedback from the more than 100,000 total student participants to date, as well as from the educators and staff who supported these offerings, suggest that online education with cloud-based GIS is scalable to very large audiences. Lessons learned from the course design, development, and delivery of these early examples may be useful in informing the continuing development of CyberGIS education. While MOOCs may have passed the peak of their "hype cycle" in higher education, the phenomenon they revealed persists: namely, a global mass market of educated young adults who turn to free online education to expand their horizons. The

  4. International year of Chemistry 2011. A guide to the history of clinical chemistry.

    Science.gov (United States)

    Kricka, Larry J; Savory, John

    2011-08-01

    This review was written as part of the celebration of the International Year of Chemistry 2011. In this review we provide a chronicle of the history of clinical chemistry, with a focus on North America. We outline major methodological advances and trace the development of professional societies and journals dedicated to clinical chemistry. This review also serves as a guide to reference materials for those interested in the history of clinical chemistry. The various resources available, in sound recordings, videos, moving images, image and document archives, museums, and websites dedicated to diagnostic company timelines, are surveyed. These resources provide a map of how the medical subspecialty of clinical chemistry arrived at its present state. This information will undoubtedly help visionaries to determine in which direction clinical chemistry will move in the future.

  5. [Summarization of the modern history of 60 years of infectious diseases].

    Science.gov (United States)

    Feng, Qiu-ji

    2010-01-01

    During 60 years of establishment of the new China, the research on the modern history of infectious diseases went through 4 stages, that is the stage of materials arrangement and difficult beginning, the stage of gradual development within the frame of the history of medicine, the stage of structured development and multiple visual angles, and the stage of complete development with multiple levels. Many achievements were obtained, such as the research group increasing gradually, a more logical knowledge structure of scholars, emergence of the aim of human solicitude, and wider research viewpoints. However, there were some weaknesses, such as the shortage of further research of achievements, the regional imbalance of research, simplex diseases, and little attention paid to the activities of missionaries.

  6. Juvenile osteochondritis dissecans: a 5-year review of the natural history using clinical and MRI evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, Jacqueline A.; Cook, Jane V.; Warren, Mary E. [Radiology Department, Queen Mary' s Hospital for Children, Epsom and St Helier NHS Trust, Carshalton, Surrey SM5 1AA (United Kingdom); Churchill, Mark A. [Orthopaedic Department, Queen Mary' s Hospital for Children, Epsom and St Helier NHS Trust, Carshalton (United Kingdom)

    2003-06-01

    Although MRI prognostic features for juvenile osteochondritis dissecans (JOCD) have been determined, the natural history of JOCD on serial MRI has not been fully documented. To document the natural history of JOCD on serial MRI and to correlate this with arthroscopy and clinical outcome over a 5-year follow-up. Twenty-one knees in 19 patients (15 boys, 4 girls; age range 5-15 years) with JOCD underwent MRI and clinical follow-up over 5 years. Lesions were classified as stable or unstable on MRI and compared with clinical and arthroscopic data. On 5-year follow-up, 17 of 19 patients were asymptomatic and 2 of 19 had minimal pain. Fourteen arthroscopies were performed on 11/21 knees. One of twenty-one had fragment fixation. On initial MRI, eight knees had marked fragmentation, high signal at the fragment/bone interface and incomplete defects in the hyaline cartilage (MRI stage III-stable), but no tear. Of these, five had arthroscopy, all confirming intact cartilage. One of twenty-one knees was unstable (MRI stage IVb) with a detached osteochondral fragment, requiring surgery. Despite extensive subchondral bone changes on MRI, all cases with intact cartilage (95%) improved with conservative treatment. Early MRI allows prompt diagnosis and institution of conservative treatment. This results in healing and avoidance of surgery in most patients. (orig.)

  7. The continuous time random walk, still trendy: fifty-year history, state of art and outlook

    Science.gov (United States)

    Kutner, Ryszard; Masoliver, Jaume

    2017-03-01

    In this article we demonstrate the very inspiring role of the continuous-time random walk (CTRW) formalism, the numerous modifications permitted by its flexibility, its various applications, and the promising perspectives in the various fields of knowledge. A short review of significant achievements and possibilities is given. However, this review is still far from completeness. We focused on a pivotal role of CTRWs mainly in anomalous stochastic processes discovered in physics and beyond. This article plays the role of an extended announcement of the Eur. Phys. J. B Special Issue [ctrw-50-years-on">http://epjb.epj.org/open-calls-for-papers/123-epj-b/1090-ctrw-50-years-on] containing articles which show incredible possibilities of the CTRWs. Contribution to the Topical Issue "Continuous Time Random Walk Still Trendy: Fifty-year History, Current State and Outlook", edited by Ryszard Kutner and Jaume Masoliver.

  8. Plant and equipment division laboratory services series: a ten-year building-maintenance cost history

    Energy Technology Data Exchange (ETDEWEB)

    Keesee, H.F.

    1976-09-01

    Maintaining a multifacility national laboratory in a safe, reliable condition is a complex management responsibility in terms of budgets, costs, and proper utilization of personnel and material resources. Increasing wage rates and material costs, combined with decreased budgets and aging facilities, create unusual challenges to maintenance managers. A ten-year history of building-maintenance costs, a brief description of the maintenance program, analyses of personnel requirements, cost increase indexes, unit costs, cost controls, procedures, and a brief discussion of alterations and improvements are presented.

  9. Plant and equipment division laboratory services series: a ten-year building-maintenance cost history

    International Nuclear Information System (INIS)

    Keesee, H.F.

    1976-09-01

    Maintaining a multifacility national laboratory in a safe, reliable condition is a complex management responsibility in terms of budgets, costs, and proper utilization of personnel and material resources. Increasing wage rates and material costs, combined with decreased budgets and aging facilities, create unusual challenges to maintenance managers. A ten-year history of building-maintenance costs, a brief description of the maintenance program, analyses of personnel requirements, cost increase indexes, unit costs, cost controls, procedures, and a brief discussion of alterations and improvements are presented

  10. A Host of Histories: Helping Year 9s Explore Multiple Narratives through the History of a House

    Science.gov (United States)

    Waters, David

    2014-01-01

    Described by the author Monica Ali as a building that 'sparks the imagination and sparks conversations', 19 Princelet Street, now a Museum of Diversity and Immigration, captivated the imagination of teacher David Waters. He was struck by the building's potential not merely for exploring the diverse histories of migrant communities in London, but…

  11. [Review and reflection of the research of history of plague in modern China in recent 25 years].

    Science.gov (United States)

    Shangguan, D Y

    2016-05-01

    Influenced by the research on history of disease abroad, the research on the history of plague in modern China began in 1989. For the recent 25 years, the related researches on plague mainly took place in Guangzhou, Hong Kong, the Northeast and Shanxi, supplemented by other places, showing its clear regional characteristic, with diversified research views, methods and application of materials. As an important content of research on disease history, the research of history of plague in modern China revealed obvious defects, viz. mainly traditional and one-way or linear research, reflecting the research was still at the borderland. Of late years, some scholars began to break through the limitation of traditional historical concept and method, and try to apply the interdisciplinary view for widening the research scope. With the promotion of this academic concept, the research of plague history began " to regard history by a bottom-up approach" , and paid more attention to the living space.

  12. Grading of Pupils in History: One-Year Research in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Vomáčková Helena

    2017-08-01

    Full Text Available Introduction: The aim of the research was to point to a wide range of factors of the pupils’ grading in History classes and to find out if this grading on the given sample corresponds with the context of the independently selected variables: pupils’ weight, inclination to the Socratic type of values, type of family, and parents’ education. Methods: A sample of 1819 7th grade pupils was made up of the pupils of randomly addressed primary schools willing to cooperate. In the course of one school year, a questionnaire survey was carried out on this sample: each of the 14 regions of the Czech Republic was represented by 5 to 9% of the respondents. Data were evaluated at a 5% level of significance by means of the Chi-squared test. Results: In all the monitored cases, a statistically significant link was demonstrated between the dependent variable (pupils’ grading and independent variables, i.e. the results in History have a wide-spectrum effect. Discussion: The research findings correspond with the results obtained by other scholars, and external factors (independent variables significantly affect the pupils’ school success regardless of their mental and intellectual dispositions. Limitations: School success is simply monitored through numerical grading of pupils, which does not always and completely reflect the pupils’ progress in terms of their development. It was not a longitudinal survey but only a single one-year research from which no major conclusions can be drawn. Conclusions: It was confirmed that the results of pupils in History, or their historical knowledge, represent a broad-spectrum matter in which the multiplication effect of external influences must be counted. In the future, research should be carried out in longer time ranges and with a greater emphasis on the causality of the phenomena.

  13. Parental depressive history, parenting styles, and child psychopathology over 6 years: The contribution of each parent's depressive history to the other's parenting styles.

    Science.gov (United States)

    Kopala-Sibley, Daniel C; Jelinek, Caitlin; Kessel, Ellen M; Frost, Allison; Allmann, Anna E S; Klein, Daniel N

    2017-10-01

    The link between parental depressive history and parenting styles is well established, as is the association of parenting with child psychopathology. However, little research has examined whether a depressive history in one parent predicts the parenting style of the other parent. As well, relatively little research has tested transactional models of the parenting-child psychopathology relationship in the context of parents' depressive histories. In this study, mothers and fathers of 392 children were assessed for a lifetime history of major depression when their children were 3 years old. They then completed measures of permissiveness and authoritarianism and their child's internalizing and externalizing symptoms when children were 3, 6, and 9 years old. The results showed that a depressive history in one parent predicted the other parent's permissiveness. Analyses then showed that child externalizing symptoms at age 3 predicted maternal permissiveness and authoritarianism and paternal permissiveness at age 6. Maternal permissiveness at age 6 predicted child externalizing symptoms at age 9. No relationships in either direction were found between parenting styles and child internalizing symptoms. The results highlight the importance of considering both parents' depressive histories when understanding parenting styles, and support transactional models of parenting styles and child externalizing symptoms.

  14. Parental depressive history, parenting styles, and child psychopathology over six years: The contribution of each parent’s depressive history to the other’s parenting styles

    Science.gov (United States)

    Kopala-Sibley, Daniel C.; Jelinek, Caitlin; Kessel, Ellen; Frost, Allison; Allmann, Anna E.S.; Klein, Daniel N.

    2017-01-01

    The link between parental depressive history and parenting styles is well established, as is the association of parenting with child psychopathology. However, little research has examined whether a depressive history in one parent predicts the parenting style of the other parent. As well, relatively little research has tested transactional models of the parenting-child psychopathology relationship in the context of parents’ depressive histories. In this study, mothers and fathers of 392 children were assessed for a lifetime history of major depression when their children were 3 years old. They then completed measures of permissiveness and authoritarianism and their child’s internalizing and externalizing symptoms when children were 3, 6, and 9 years old. Results showed that a depressive history in one parent predicted the other parent’s permissiveness. Analyses then showed that child externalizing symptoms at age 3 predicted maternal permissiveness and authoritarianism and paternal permissiveness at age 6. Maternal permissiveness at age 6 predicted child externalizing symptoms at age 9. No relationships in either direction were found between parenting styles and child internalizing symptoms. Results highlight the importance of considering both parents’ depressive histories when understanding parenting styles, and support transactional models of parenting styles and child externalizing symptoms. PMID:28414019

  15. 500,000 Years of Environmental History in Eastern Anatolia: The PALEOVAN Drilling Project

    Directory of Open Access Journals (Sweden)

    Clemens Glombitza, and Jens Kallmeyer

    2012-09-01

    Full Text Available International Continental Scientific Drilling Program (ICDP drilled a complete succession of the lacustrine sediment sequence deposited during the last ~500,000 years in Lake Van, Eastern Anatolia (Turkey. Based on a detailed seismic site survey, two sites at a water depth of up to 360 m were drilled in summer 2010, and cores were retrieved from sub-lake-floor depths of 140 m (Northern Basin and 220 m (Ahlat Ridge. To obtain a complete sedimentary section, the two sites were multiple-cored in order to investigate the paleoclimate history of a sensitive semi-arid region between theBlack, Caspian, and Mediterranean seas. Further scientific goals of the PALEOVAN project are the reconstruction of earthquake activity, as well as the temporal, spatial, and compositional evolution of volcanism as reflected in the deposition of tephra layers. The sediments host organic matter from different sources and hence composition, which will be unravelled using biomarkers. Pathways for migration of continental and mantle-derived noble gases will be analyzed in pore waters. Preliminary 40Ar/39Ar single crystal dating of tephra layers and pollen analyses suggest that the AhlatRidge record encompasses more than half a million years of paleoclimate and volcanic/geodynamic history, providing the longest continental record in the entire Near East to date.

  16. 500,000 Years of Environmental History in Eastern Anatolia: The PALEOVAN Drilling Project

    Science.gov (United States)

    Litt, T.; Anselmetti, F. S.; Baumgarten, H.; Beer, J.; Cagatay, N.; Cukur, D.; Damci, E.; Glombitza, C.; Haug, G.; Heumann, G.; Kallmeyer, H.; Kipfer, R.; Krastel, S.; Kwiecien, O.; Meydan, A. F.; Orcen, S.; Pickarski, N.; Randlett, M.-E.; Schmincke, H.-U.; Schubert, C. J.; Sturm, M.; Sumita, M.; Stockhecke, M.; Tomonaga, Y.; Vigliotti, L.; Wonik, T.; Paleovan Scientific Team

    2012-09-01

    International Continental Scientific Drilling Program (ICDP) drilled a complete succession of the lacustrine sediment sequence deposited during the last ~500,000 years in Lake Van, Eastern Anatolia (Turkey). Based on a detailed seismic site survey, two sites at a water depth of up to 360 m were drilled in summer 2010, and cores were retrieved from sub-lake-floor depths of 140 m (Northern Basin) and 220 m (Ahlat Ridge). To obtain a complete sedimentary section, the two sites were multiple-cored in order to investigate the paleoclimate history of a sensitive semi-arid region between the Black, Caspian, and Mediterranean seas. Further scientific goals of the PALEOVAN project are the reconstruction of earthquake activity, as well as the temporal, spatial, and compositional evolution of volcanism as reflected in the deposition of tephra layers. The sediments host organic matter from different sources and hence composition, which will be unravelled using biomarkers. Pathways for migration of continental and mantle-derived noble gases will be analyzed in pore waters. Preliminary 40Ar/39Ar single crystal dating of tephra layers and pollen analyses suggest that the Ahlat Ridge record encompasses more than half a million years of paleoclimate and volcanic/geodynamic history, providing the longest continental record in the entire Near East to date. doi:10.2204/iodp.sd.14.02.2012

  17. Essay-writing module for second-year students of history

    Directory of Open Access Journals (Sweden)

    Carstens, Adelia

    2008-12-01

    Full Text Available Increasing evidence from corpus, discourse and genre analysis has indicated that there is significant variation between disciplines in the way that they structure their discourses, in particular their written genres. Therefore, discipline-specific approaches in language teaching have gained much support in recent years. However, few studies have thus far given a systematic account of relationships between disciplinary purposes and writing conventions, or have used such information as input for course design. This article analyses the purposes of historical writing, and relates these to the salient concepts, genres and modes found in historical discourse. In particular, the discursive and lexicogrammatical choices that are available to the historian for the construal of time, cause and effect, and judgement or evaluation are explored. One particular aspect of evaluation, viz. engagement, is teased out in more detail to demonstrate the pedagogical value of corpus-based genre analysis. The findings underscore the assumption that disciplinary purposes shape texts in a discipline, and show that there is a clear relationship between the main purposes of a subject-field and its writing conventions – at least as far as History is concerned. A genre-based syllabus for a writing course aimed at second-year students of history is subsequently proposed, and a preview is given of the follow-up research that is envisaged to evaluate the effect of the intervention as well as to compare it with the effect of a generic intervention.

  18. Tokamaks: from A D Sakharov to the present (the 60-year history of tokamaks)

    International Nuclear Information System (INIS)

    Azizov, E A

    2012-01-01

    The paper is prepared on the basis of the report presented at the session of the Physical Sciences Division of the Russian Academy of Sciences (RAS) at the Lebedev Physical Institute, RAS on 25 May 2011, devoted to the 90-year jubilee of Academician Andrei D Sakharov - the initiator of controlled nuclear fusion research in the USSR. The 60-year history of plasma research work in toroidal devices with a longitudinal magnetic field suggested by Andrei D Sakharov and Igor E Tamm in 1950 for the confinement of fusion plasma and known at present as tokamaks is described in brief. The recent (2006) agreement among Russia, the EU, the USA, Japan, China, the Republic of Korea, and India on the joint construction of the international thermonuclear experimental reactor (ITER) in France based on the tokamak concept is discussed. Prospects for using the tokamak as a thermonuclear (14 MeV) neutron source are examined. (conferences and symposia)

  19. The joint impact of family history of myocardial infarction and other risk factors on 12-year coronary heart disease mortality

    NARCIS (Netherlands)

    Boer, J M; Feskens, E.J.; Verschuren, W M Monique; Seidell, J C; Kromhout, D.

    1999-01-01

    We investigated the impact of family history of myocardial infarction on 12-year coronary heart disease mortality. Men and women with a family history had an increased risk for coronary heart disease death, irrespective of other risk factors (RR = 1.58; 95% CI = 1.17-2.13 and RR = 2.12; 95% CI =

  20. How the world survived the population bomb: lessons from 50 years of extraordinary demographic history.

    Science.gov (United States)

    Lam, David

    2011-11-01

    The world population will reach 7 billion in late 2011, a demographic milestone that is causing renewed attention to the challenges caused by population growth. This article looks at the last 50 years of demographic change, one of the most extraordinary periods in demographic history. During this period, world population grew at rates that have never been seen before and will almost surely never be seen again. There were many concerns about the potential impact of rapid population growth in the 1960s, including mass starvation in countries such as India, depletion of nonrenewable resources, and increased poverty in low-income countries. The actual experience was very different. World food production increased faster than world population in every decade since the 1960s, resource prices fell during most of the period, and poverty declined significantly in much of the developing world. The article considers the economic and demographic explanations for the surprising successes of this important period in demographic history. It also looks at regions that have been less successful, especially Africa, and at the lessons for dealing with the important challenges that still remain.

  1. ENVIRONMENTAL RADIATION MONITORING IN THE CHERNOBYL EXCLUSION ZONE - HISTORY AND RESULTS 25 YEARS AFTER

    Energy Technology Data Exchange (ETDEWEB)

    Farfan, E.; Jannik, T.

    2011-10-01

    This article describes results of the radiation environmental monitoring performed in the Chernobyl Exclusion Zone (ChEZ) during the period following the 1986 Chernobyl Nuclear Power Plant accident. This article presents a brief overview of five comprehensive reports generated under Contract No. DE-AC09-96SR18500 (Washington Savannah River Company LLC, Subcontract No. AC55559N, SOW No. ON8778) and summarizes characteristics of the ChEZ and its post-accident status and the history of development of the radiation monitoring research in the ChEZ is described. This article addresses characteristics of the radiation monitoring in the ChEZ, its major goals and objectives, and changes of these goals and objectives in the course of time, depending on the tasks associated with the phase of mitigation of the ChNPP accident consequences. The results of the radiation monitoring in the ChEZ during the last 25 years are also provided.

  2. Emotional intelligence: a theoretical and empirical review of its first 15 years of history.

    Science.gov (United States)

    Fernández-Berrocal, Pablo; Extremera, Natalio

    2006-01-01

    The term Emotional Intelligence (EI) was first introduced in the scientific literature in 1990. Since then, the development of models of EI and research in this field has increased substantially. In this manuscript, a theoretical and empirical review of the first 15 years of history of EI is presented. First, the broad interest on this concept is shown through qualitative and quantitative indexes. Then, current theoretical models of EI: the mental ability model; the Bar-On Model of Emotional-Social Intelligence; and Goleman's model of EI are described in depth. Finally, authors give relevant keys about future considerations for research on EI. Specifically, authors 1) propose some ideas concerning the measurement of the construct and the use of ability and self-reported measures; 2) discuss the learning, development, and training potential of EI; and 3) consider the cross-cultural validity of EI.

  3. Intraocular pressure 1 year after vitrectomy in eyes without a history of glaucoma or ocular hypertension

    Directory of Open Access Journals (Sweden)

    Fang Y

    2017-11-01

    Full Text Available Yuan Fang,1 Qingqing Long,1 Xiaoqian Wang,2 Rui Jiang,1 Xinghuai Sun1,3–5 1Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, 2Department of Ophthalmology, Jiangyin Bright Eye Hospital, Jiangyin, Jiangsu, 3State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, 4Key Laboratory of Myopia, NHFPC (Fudan University, 5Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, People’s Republic of China Objective: The aim of this study was to investigate the incidence, risk factors, and treatment of elevated intraocular pressure (IOP 1 year after vitrectomy in eyes without a history of glaucoma or ocular hypertension.Patients and methods: This retrospective study comprised 256 eyes from 256 consecutive patients without a history of glaucoma or ocular hypertension who underwent vitrectomy and were followed up for 1 year. The incidence of elevated IOP at 1 year after vitrectomy was calculated. We compared the characteristics of patients with or without elevated IOP to identify possible risk factors for elevated IOP. The treatments used to control IOP were recorded and analyzed.Results: A total of 50 patients (19.5% had elevated IOP after vitrectomy at the 1-year follow-up. Tamponade was a significant risk factor for elevated IOP (P<0.05. The cumulative rates of elevated IOP in eyes with air, balanced salt solution, sulfur hexafluoride, perfluoropropane (C3F8, and silicone oil as the tamponade were 0, 10.8%, 5.9%, 19.8%, and 28.4%, respectively (P<0.05. About 68% of cases of elevated IOP occurred within 1 month after vitrectomy. At 1 year after vitrectomy, 29 patients (58.0% had stopped their IOP-lowering drugs and 21 (42.0% patients were continuing these drugs. About 65% of ocular hypertension patients who received silicone oil tamponade had not stopped IOP-lowering drugs

  4. Family history of psychosis and outcome of people with schizophrenia in rural China: 14-year follow-up study.

    Science.gov (United States)

    Ran, Mao-Sheng; Xiao, Yunyu; Zhao, Xinyi; Zhang, Tian-Ming; Yu, Yue-Hui; Mao, Wen-Jun; Lin, Fu-Rong; Liu, Bo; Chan, Cecilia Lai-Wan

    2018-02-01

    This study examined the differences in 14-year outcomes of persons with schizophrenia with and without family history of psychosis in a rural community in China. All participants with schizophrenia (n=510) aged 15 years and older were identified in a 1994 epidemiological investigation of 123,572 people and followed up in 2004 and 2008 in Xinjin County, Chengdu, China. Individuals with positive family history of schizophrenia had significantly younger age of first onset than those with negative family history of schizophrenia in 1994 and 2004. Compared with individuals with negative family history of schizophrenia, those with positive family history of schizophrenia had significantly higher rate of homelessness and lower rate of death due to other reasons in 10-year (2004) and 14-year follow-up (2008). There were no significantly differences of mean scores on PANSS, SDSS and GAF in 2008 between positive and negative family history groups. The positive family history of schizophrenia is strongly related to younger age of onset, and may predict a poorer long-term outcome (e.g., higher rate of homelessness) in persons with schizophrenia in the rural community. The findings have implications for further studies on specific family-related mechanisms on clinical treatment and rehabilitation, as well as for planning and delivering of community-based mental health services. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Persistent urinary incontinence and delivery mode history: a six-year longitudinal study.

    Science.gov (United States)

    MacArthur, Christine; Glazener, Cathryn M A; Wilson, P Don; Lancashire, Robert J; Herbison, G Peter; Grant, Adrian M

    2006-02-01

    To investigate the prevalence of persistent and long term postpartum urinary incontinence and associations with mode of first and subsequent delivery. Longitudinal study. Maternity units in Aberdeen (Scotland), Birmingham (England) and Dunedin (New Zealand). Women (4214) who returned postal questionnaires three months and six years after the index birth. Symptom data were obtained from both questionnaires and obstetric data from case-notes for the index birth and the second questionnaire for subsequent births. Logistic regression investigated the independent effects of mode of first delivery and delivery mode history. Urinary incontinence-persistent (at three months and six years after index birth) and long term (at six years after index birth). The prevalence of persistent urinary incontinence was 24%. Delivering exclusively by caesarean section was associated with both less persistent (OR=0.46, 95% CI 0.32-0.68) and long term urinary incontinence (OR=0.50, 95% CI 0.40-0.63). Caesarean section birth in addition to vaginal delivery, however, was not associated with significantly less persistent incontinence (OR 0.93, 95% CI 0.67-1.29). There were no significant associations between persistent or long term urinary incontinence and forceps or vacuum extraction delivery. Other significantly associated factors were increasing number of births and older maternal age. The risk of persistent and long term urinary incontinence is significantly lower following caesarean section deliveries but not if there is another vaginal birth. Even when delivering exclusively by caesarean section, the prevalence of persistent symptoms (14%) is still high.

  6. 1,100,000 year history of Siberian permafrost based on U-Pb chronology of speleothems

    Science.gov (United States)

    Vaks, Anton; Mason, Andrew J.; Breitenbach, Sebastian F. M.; Kononov, Alexander M.; Osintcev, Alexander V.; Henderson, Gideon M.

    2014-05-01

    We have used U-Pb dating of the speleothems from Siberian Ledyanaya Lenskaya Cave for tracing of permafrost thawing events during the last 1.1 million years. Rain and snowmelt waters can penetrate into caves only when the soil and subsoil temperatures are above 0° C and permafrost above the cave is discontinuous or absent. Therefore, speleothems in regions currently affected by permafrost provide a tracer of past permafrost thawing events. Ledyanaya Lenskaya Cave is located at 60° 22'N-116° 57'E, on the southern boundary of continuous permafrost zone, with no present-day water seepage in the cave. Temperatures in the region range from -32° C (January) to +18° C (July), with mean annual temperature of ~-6° C. U-Th dating of speleothems from this cave in a previous study [1] showed that the youngest speleothem growth period occurred at 427±23 thousand years ago (ka), during the early Marine Isotope Stage (MIS) 11. During this episode global temperature was 1.5° C higher than pre-industrial levels, and ~0.7° C above the present. In the current study two horizons at the base of a stalagmite were dated using U-Pb chronology [2]. Isochron ages of 1074.1 +7.9/-6.9 ka and 951.4 +3.6/-4.4 ka were obtained. Timing of these permafrost thawing events correlates with events of exceptionally high Pacific Warm Pool sea surface temperature (~+30° C)[3]. During these warm episodes the average global temperature was 1.2-1.3° C higher than pre-industrial temperatures. These findings put the threshold of thawing of the continuous permafrost near its southern boundary slightly lower than it was found previously. The dating work is still in process and is now focusing on growth periods older than MIS-11 but younger than 950 ka. The oldest horizon of the stalagmite grew on the bedrock. This layer was probably amongst the first vadose speleothems that formed after the cave was uplifted above the groundwater table (associated with the nearby Lena River). Today the cave is ~50

  7. Polycythemia vera: the natural history of 1213 patients followed for 20 years. Gruppo Italiano Studio Policitemia.

    Science.gov (United States)

    1995-11-01

    To reassess the natural history of polycythemia vera and to obtain reliable estimates of both incidence of thrombosis and survival for use in defining the sample size for therapeutic clinical trials. Retrospective cohort study of patients with polycythemia who had been followed for 20 years. 11 Italian hematology institutions. 1213 patients with polycythemia vera, which was diagnosed according to criteria established by the Polycythemia Vera Study Group and commonly used in clinical practice. All-cause mortality, venous and arterial thrombosis, and hematologic and nonhematologic neoplastic disease. Myocardial infarction and stroke were classified as major thrombotic events, and venous and peripheral arterial thrombosis were considered minor thrombotic events. The number of patients who died and the number of those who had major thrombotic events (combined end point) were used as a comprehensive measure of the benefit-risk ratio associated with the use of myelosuppressive agents. 634 fatal and nonfatal arterial and venous thromboses were recorded in 485 patients (41%); 36% of these episodes occurred during follow-up in 230 patients (19%), and 64% occurred either at presentation or before diagnosis. Thrombotic events occurred more frequently in the 2 years preceding diagnosis, suggesting a causal relation between the latent myeloproliferative disorder and the vascular event. The incidence of thrombosis during follow-up was 3.4%/y; older patients or those with a history of thrombosis had a higher risk for thrombosis. Overall mortality was 2.9/100 patients per year; thrombotic events and hematologic or nonhematologic cancers had similar effects on mortality. Patients receiving chemotherapy died three to four times more frequently than those not receiving chemotherapy. The increased risk for cancer in patients receiving myelosuppressive agents was seen approximately 6 years after diagnosis. In addition, the combined end point, computed as the sum of the hardest

  8. One hundred million years of mantle geochemical history suggest the retiring of mantle plumes is premature

    Science.gov (United States)

    Konter, Jasper G.; Hanan, Barry B.; Blichert-Toft, Janne; Koppers, Anthony A. P.; Plank, Terry; Staudigel, Hubert

    2008-11-01

    Linear chains of intraplate volcanoes and their geochemistry provide a record of mantle melting through geological time. The isotopic compositions of their lavas characterize their mantle sources, and their ages help backtrack these volcanoes to their original, eruptive source regions. Such data may shed light on a much-debated issue in Earth Sciences: the origin of intraplate volcanism and its underlying mantle and lithosphere dynamics. We show here that three major Western Pacific Seamount groups, ˜ 50-100 million years in age, display distinct Sr, Nd, Hf, and Pb isotopic signatures that can be traced back in time, both geographically and geochemically, to three separate, recently-active intraplate volcanoes in the South Pacific Cook-Austral Islands. Their unique 100 million year history, which shows a persistent geochemical fingerprint, suggests formation from large volumes of laterally fixed, long-lived source regions. Such longevity is unlikely to be attained in the relatively dynamic upper mantle. Therefore, these sources are likely anchored deep in the mantle, isolated from homogenization by mantle convection, and imply a primary origin from deep mantle plumes rather than resulting from lithosphere extension.

  9. The history of South American tropical precipitation for the past 25,000 years.

    Science.gov (United States)

    Baker, P A; Seltzer, G O; Fritz, S C; Dunbar, R B; Grove, M J; Tapia, P M; Cross, S L; Rowe, H D; Broda, J P

    2001-01-26

    Long sediment cores recovered from the deep portions of Lake Titicaca are used to reconstruct the precipitation history of tropical South America for the past 25,000 years. Lake Titicaca was a deep, fresh, and continuously overflowing lake during the last glacial stage, from before 25,000 to 15,000 calibrated years before the present (cal yr B.P.), signifying that during the last glacial maximum (LGM), the Altiplano of Bolivia and Peru and much of the Amazon basin were wetter than today. The LGM in this part of the Andes is dated at 21,000 cal yr B.P., approximately coincident with the global LGM. Maximum aridity and lowest lake level occurred in the early and middle Holocene (8000 to 5500 cal yr B.P.) during a time of low summer insolation. Today, rising levels of Lake Titicaca and wet conditions in Amazonia are correlated with anomalously cold sea-surface temperatures in the northern equatorial Atlantic. Likewise, during the deglacial and Holocene periods, there were several millennial-scale wet phases on the Altiplano and in Amazonia that coincided with anomalously cold periods in the equatorial and high-latitude North Atlantic, such as the Younger Dryas.

  10. A Portrait of One Hundred Thousand and One Galaxies

    Science.gov (United States)

    2002-08-01

    significant lensing effect for one of the galaxy clusters in the field ( CL0053-37 , see PR Photo 18d/02 ); the images of background galaxies around this cluster were noticeably distorted in the direction tangential to the cluster center. Based on the measured degree of distortion, a map of the distribution of (dark) matter in this direction was constructed ( PR Photo 18e/02 ). The separation of unlensed foreground (bluer) and lensed background galaxies (redder) greatly profited from the photometric measurements done by Gieren's group in the course of their work on the Cepheids in NGC 300. Assuming that the lensed background galaxies lie at a mean redshift of 1.0, i.e. a distance of 8 billion light-years, a mass of about 2 x 10 14 solar masses was obtained for the CL0053-37 cluster. This lensing analysis in the NGC 300 field is part of the Garching-Bonn Deep Survey (GaBoDS) , a weak gravitational lensing survey led by Peter Schneider (IAEF). GaBoDS is based on exposures made with the WFI and until now a sky area of more than 12 square degrees has been imaged during very good seeing conditions. Once complete, this investigation will allow more insight into the distribution and cosmological evolution of galaxy cluster masses, which in turn provide very useful information about the structure and history of the Universe. One hundred thousand galaxies ESO PR Photo 18f/02 ESO PR Photo 18f/02 [Preview - JPEG: 400 x 526 pix - 93k] [Full-Res - JPEG: 756 x 994 pix - 1.0M] Caption : PR Photo 18f/02 shows a group of galaxies , seen on the NGC 300 images. They are all quite red and their similar colours indicate that they must be about equally distant. They probably constitute a distant cluster, now in the stage of formation. Technical information about this photo is available below. ESO PR Photo 18g/02 ESO PR Photo 18g/02 [Preview - JPEG: 469 x 400 pix - xxk] [Full-Res - JPEG: 1055 x 899 pix - 968k] Caption : PR Photo 18g/02 shows an area in the outer regions of NGC 300. Disks of spiral

  11. THE SOUTHERN FRAGMENT OF THE SIBERIAN CRATON: “LANDSCAPE” HISTORY OVER TWO BILLION YEARS

    Directory of Open Access Journals (Sweden)

    Arkady M. Stanevich

    2010-01-01

    Full Text Available In the state-of-the-art geology, concepts of evolution of interrelated geodynamic and biotic events throughout the history of the Earth have been developed (Fig. 1. Research results on sediments, bio-stratigraphy and geodynamics of the southern fragment of the Siberian craton (SSC, Fig. 2 provide for more or less reliable assessments of the status and evolution of ancient landscapes and biotas from the Lower Proterozoic to the Cenozoic.In the Lower Proterozoic, the geodynamic regime of the Urik-Iyskiy graben was similar to those of the westernpacific island-arc systems, which resulted in the orogen formation and established post-orogen granitoids of 1.86 bln years of age. At the beginning of the Early Riphean, volcano-sedimentary masses were accumulated in continental basins (Fig. 2, 3A. Collision orogenesis also resulted in the occurrence of the terrigeno-volcanogenic complex of the Akitkanskaya suite in the Western Pribaikalie and the transecting Irelskiy granitoids, aged 1.86 bln years, at the edge of the craton. Later on, most probably before the Riphean, peneplanation took place, and a shallow peripheral sea was formed with highly-mature sediments of the Purpolskaya suite. Different environments are reconstructed in the KodarUdokan zone. Sediments of the Udokanskaya suite, varying in thicknesses from 11 to 14 km, suggest a complicated evolution of sedimentation in the peripheral marine basin. Dozens of radiochronological datings of granitoids of the Chuiskiy and Kodarskiy complex which transect the Udokanskaya suite are within the range from 1.7 to 2.0 bln years. From the deposit composition and texture, it can be suggested that the middle, Chineiskaya sub-suite was formed under island-arc conditions; and glacial phenomena occurred in the late Udokan time.Further geological history of the SSC can be described only within the period after the Late Riphean sedimentations (see Fig. 3Б, В. The SSC evolution in the Neo-Proterozoic began with

  12. Big History or the 13800 million years from the Big Bang to the Human Brain

    Science.gov (United States)

    Gústafsson, Ludvik E.

    2017-04-01

    Big History is the integrated history of the Cosmos, Earth, Life, and Humanity. It is an attempt to understand our existence as a continuous unfolding of processes leading to ever more complex structures. Three major steps in the development of the Universe can be distinguished, the first being the creation of matter/energy and forces in the context of an expanding universe, while the second and third steps were reached when completely new qualities of matter came into existence. 1. Matter comes out of nothing Quantum fluctuations and the inflation event are thought to be responsible for the creation of stable matter particles in what is called the Big Bang. Along with simple particles the universe is formed. Later larger particles like atoms and the most simple chemical elements hydrogen and helium evolved. Gravitational contraction of hydrogen and helium formed the first stars und later on the first galaxies. Massive stars ended their lives in violent explosions releasing heavier elements like carbon, oxygen, nitrogen, sulfur and iron into the universe. Subsequent star formation led to star systems with bodies containing these heavier elements. 2. Matter starts to live About 9200 million years after the Big Bang a rather inconspicous star of middle size formed in one of a billion galaxies. The leftovers of the star formation clumped into bodies rotating around the central star. In some of them elements like silicon, oxygen, iron and many other became the dominant matter. On the third of these bodies from the central star much of the surface was covered with an already very common chemical compound in the universe, water. Fluid water and plenty of various elements, especially carbon, were the ingredients of very complex chemical compounds that made up even more complex structures. These were able to replicate themselves. Life had appeared, the only occasion that we human beings know of. Life evolved subsequently leading eventually to the formation of multicellular

  13. Twelve-year history of late-life depression and subsequent feelings to God.

    Science.gov (United States)

    Braam, Arjan W; Schaap-Jonker, Hanneke; van der Horst, Marleen H L; Steunenberg, Bas; Beekman, Aartjan T F; van Tilburg, Willem; Deeg, Dorly J H

    2014-11-01

    Growing evidence shows several possible relations between religiousness and late-life depression. Emotional aspects of religiousness such as facets of the perceived relationship with God can be crucial in this connection. The aim of the current study was to examine the association between the course of late-life depression and feelings about God and religious coping. Longitudinal survey study; naturalistic; 12-year follow-up. Longitudinal Aging Study Amsterdam; population-based, in three regions in The Netherlands. A subsample of 343 respondents (mean age: 77.2 years), including all respondents with high levels of depressive symptoms at any measurement cycle between 1992 and 2003 (assessed by using the Center for Epidemiologic Studies Depression Scale and the Diagnostic Interview Schedule) and a random sample of nondepressed respondents who completed a postal questionnaire in 2005. Scales on God Image and Religious Coping. Twelve-year depression course trajectories serve as predicting variables and are specified according to recency and seriousness. Persistent and emergent depression are significantly associated with fear of God, feeling wronged by God, and negative religious coping. In terms of negative religious coping, significant associations were observed after adjustment for concurrent depression with a history of repeated minor depression and previous major depression. Late-life depression seems to maintain a pervasive relationship over time with affective aspects of religiousness. Religious feelings may parallel the symptoms of anhedonia or a dysphoric mood and could represent the experience of an existential void. Copyright © 2014 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

  14. The European Society of Human Genetics: beginnings, early history and development over its first 25 years.

    Science.gov (United States)

    Harper, Peter S

    2017-05-10

    The European Society of Human Genetics (ESHG) was founded on 15 March 1967, after preliminary discussions at the International Human Genetics Congress in Chicago the previous year and in Copenhagen in early 1967. Its initial meeting was held on 18-19 November 1967, also in Copenhagen, and annual meetings have been held from that time until the present, apart from years in which the International Congress of Human Genetics was also being held. The character of the Society during its early years was strongly influenced by its founding and permanent Secretary, Jan Mohr, head of the Copenhagen Institute of Medical Genetics, whose records are archived in the Tage Kemp/Jan Mohr Archive, now part of the Danish National Archives. These records show Jan Mohr's determination to keep the activities of the Society limited to the holding of an annual meeting to enhance contacts between European human geneticists, and to resist expansion to other activities. Pressures for a wider role of ESHG became irresistible in the late 1980s and a revised constitution, adopted in 1991, reshaped the Society into a more conventional and less restrictive structure. This has allowed it to play a wider and increasingly influential role in the development of human and medical genetics across Europe, with its own Journal, a range of committees covering different aspects of the field and a series of valuable reports on specific important topics, to be described in a forthcoming article on the Society's more recent history.European Journal of Human Genetics advance online publication, 10 May 2017; doi:10.1038/ejhg.2017.34.

  15. Coolmine Therapeutic Community, Dublin: a 40-year history of Ireland's first voluntary drug treatment service.

    Science.gov (United States)

    Butler, Shane

    2016-02-01

    To document the evolution over 40 years (from 1973 to 2013) of Coolmine Therapeutic Community (Ireland's first voluntary drug treatment service) against a background of broader drug policy developments in the Republic of Ireland and elsewhere during this period. Data were gathered by means of archival research within Coolmine, complemented by semi-structured interviews with former clients, current and former Coolmine management and staff, and representatives of outsider stakeholder interests. Coolmines's history has three phases: (1) an early and uncontentious phase, in which external authorities provided financial support for Coolmine without questioning its work practices or outcomes; (2) a middle, controversial phase, in which Coolmine struggled for survival in an external policy environment now dominated by harm reduction strategies; and (3) a final phase in which, through the use of conventional corporate governance, Coolmine management sought to repair its damaged reputation by introducing evidence-based clinical practices. Coolmine Therapeutic Community was established when drug treatment services in Ireland were in their infancy, and its changing fortunes over subsequent decades reflected changing perceptions of what constitutes appropriate addiction treatment-and in particular the role to be played by former addicts within addiction treatment systems-as well as changing perceptions of funding relationships between statutory authorities and voluntary providers of health and social services. © 2015 Society for the Study of Addiction.

  16. A 36-year history of fatal road rage in Marion County, Oregon: 1963-1998.

    Science.gov (United States)

    Batten, P J; Penn, D W; Bloom, J D

    2000-03-01

    This paper documents the 36-year history, with five examples, of fatal road rage in Marion County, Oregon. Relevant details (all that were available) from each case are presented. Alcohol intoxication was present in four of our five cases. We include two deaths by gunshot at close range, two deaths as a result of a motor vehicle traffic accident, and one natural death. All subjects were males. Three were Caucasian and two were Hispanic. The three subjects in Cases 1, 2 and 3 were complete strangers to the occupants of the other involved vehicles. The subjects in Cases 4 and 5 (along with the occupants of their own vehicles) were acquaintances of the occupants of the involved vehicle. There appears to be no previous forensic, medical or psychiatric literature on road rage as such. We present an initial psychiatric evaluation of the perpetrators of this type of fatal assault. There are no specific statutes in Oregon, at the state or county levels, regarding road rage. However, the city of Gresham, Oregon, recently enacted an ordinance regarding road rage. We stress the need for further study of this phenomenon, especially through the use of the psychological-psychiatric autopsy.

  17. [500 Years of Reformation: The History of Martin Luther's Pathography and its Ethical Implications].

    Science.gov (United States)

    Braun, Birgit; Loew, Thomas

    2017-10-01

    Introduction In the context of the 500th anniversary of the Reformation, it is time to take a survey of the history of Martin Luther's (1483-1546) pathography and to deduce possible conclusions from it for psychiatric practice. Results In a 1035-page work written in German between 1937 and 1941, the Dane Paul Reiter retrospectively diagnosed Luther as manic-depressive. In 1956, Grossmann was unable to prove persistent synchronicity of depressive mood and reduced motivation in Luther in the key years 1527 and 1528, which led him to conclude that Luther had a cyclothymic personality with a pyknic constitution. Discussion One very central source of Luther's life's work may have arisen from the tension between emotional constraints and crises of faith, on the one hand, and resilience and trust in God, on the other. Conclusion Luther can be used as an example of the importance of religiousness as a curative resource for the psyche. Georg Thieme Verlag KG Stuttgart · New York.

  18. The natural history of dental caries lesions: a 4-year observational study.

    Science.gov (United States)

    Ferreira Zandoná, A; Santiago, E; Eckert, G J; Katz, B P; Pereira de Oliveira, S; Capin, O R; Mau, M; Zero, D T

    2012-09-01

    Dental caries is a ubiquitous disease affecting all age groups and segments of the population. It is known that not all caries lesions progress to cavitation, but little is known regarding the progression pattern of caries lesions. This study's purpose was to evaluate the natural history of dental caries using a standardized, visually based system, the International Caries Detection and Assessment System (ICDAS). The study population consisted of 565 consenting children, who were enrolled and examined at baseline and at regular intervals over 48 months with ICDAS and yearly bitewing radiographs. Of these, 338 children completed all examinations. Not all lesions cavitated at the same rate, differing by surface type and baseline ICDAS severity score and activity status. With increasing severity, the percentage of lesions progressing to cavitation increased: 19%, 32%, 68%, and 66% for ICDAS scores 1, 2, 3, and 4, respectively. Lesions on occlusal surfaces were more likely to cavitate, followed by buccal pits, lingual grooves, proximal surfaces, and buccal and lingual surfaces. Cavitation was more likely on molars, followed by pre-molars and anterior teeth. Predictors of cavitation included age, gender, surfaces and tooth types, and ICDAS severity/activity at baseline. In conclusion, characterization of lesion severity with ICDAS can be a strong predictor of lesion progression to cavitation.

  19. Shaping the History of Education? : The first 50 years of Paedagogica Historica

    NARCIS (Netherlands)

    Dekker, Jeroen J.H.; Simon, Frank

    2016-01-01

    In 1961 the Centre for the Study of the History of Education at Ghent University, Belgium published the first issue of the multilingual journal Paedagogica Historica: International Journal of the History of Education. This book celebrates its fiftieth volume. In fourteen contributions written by

  20. Case Report-The 46 year old man with a 5 month history of vomiting

    African Journals Online (AJOL)

    history of vomiting. Dalitso Segula1,2 Victoria Mwandiambira3, Will. Howson1, Theresa J Allain1. 1. Department of Medicine, University of Malawi College of Medicine,. Blantyre ... He had a history of moderate alcohol consumption (< 20 units per .... accident, stress and Parkinson's disease1,2and rheumatologic disorders ...

  1. Thousands of cold anti-atoms produced at CERN

    CERN Multimedia

    2002-01-01

    The antimatter factory delivers its first major results. ATHENA has just produced thousands of anti-atoms. This is the result of techniques developed by ATRAP and ATHENA, the two collaborations aiming to study antihydrogen.

  2. Reconstructing the tectonic history of Fennoscandia from its margins: The past 100 million years

    International Nuclear Information System (INIS)

    Muir Wood, R.

    1995-12-01

    In the absence of onland late Mesozoic and Cenozoic geological formations the tectonic history of the Baltic Shield over the past 100 million years can most readily be reconstructed from the thick sedimentary basins that surround Fennoscandia on three sides. Tectonic activity around Fennoscandia through this period has been diverse but can be divided into four main periods: a. pre North Atlantic spreading ridge (100-60 Ma) when transpressional deformation on the southern margins of Fennoscandia and transtensional activity to the west was associated with a NNE-SSW maximum compressive stress direction; b. the creation of the spreading ridge (60-45 Ma) when there was rifting along the western margin; c. the re-arrangement of spreading axes (45-25 Ma) when there was a radial compression around Fennoscandia, and d. the re-emergence of the Iceland hot-spot (25-0 Ma) when the stress-field has come to accord with ridge or plume 'push'. Since 60 Ma the Alpine plate boundary has had little influence on Fennoscandia. The highest levels of deformation on the margins of Fennoscandia were achieved around 85 Ma, 60-55 Ma, with strain-rates around 10 -9 /year. Within the Baltic Shield long term strain rates have been around 10 -1 1/year, with little evidence for evidence for significant deformations passing into the shield from the margins. Fennoscandian Border Zone activity, which was prominent from 90-60 Ma, was largely abandoned following the creation of the Norwegian Sea spreading ridge, and with the exception of the Lofoten margin, there is subsequently very little evidence for deformation passing into Fennoscandia. Renewal of modest compressional deformation in the Voering Basin suggest that the 'Current Tectonic Regime' is of Quaternary age although the orientation of the major stress axis has remained approximately consistent since around 10 Ma. The past pattern of changes suggest that in the geological near-future variations are to be anticipated in the magnitude rather

  3. Reconstructing the tectonic history of Fennoscandia from its margins: The past 100 million years

    Energy Technology Data Exchange (ETDEWEB)

    Muir Wood, R. [EQE International Ltd (United Kingdom)

    1995-12-01

    In the absence of onland late Mesozoic and Cenozoic geological formations the tectonic history of the Baltic Shield over the past 100 million years can be reconstructed from the thick sedimentary basins that surround Fennoscandia on three sides. Tectonic activity around Fennoscandia through this period has been diverse but can be divided into four main periods: a. pre North Atlantic spreading ridge (100-60 Ma) when transpressional deformation on the southern margins of Fennoscandia and transtensional activity to the west was associated with a NNE-SSW maximum compressive stress direction; b. the creation of the spreading ridge (60-45 Ma) when there was rifting along the western margin; c. the re-arrangement of spreading axes (45-25 Ma) when there was a radial compression around Fennoscandia, and d. the re-emergence of the Iceland hot-spot (25-0 Ma) when the stress-field has come to accord with ridge or plume `push`. Since 60 Ma the Alpine plate boundary has had little influence on Fennoscandia. The highest levels of deformation on the margins of Fennoscandia were achieved around 85 Ma, 60-55 Ma, with strain-rates around 10{sup -9}/year. Within the Baltic Shield long term strain rates have been around 10{sup -1}1/year, with little evidence for significant deformations passing into the shield from the margins. Fennoscandian Border Zone activity, which was prominent from 90-60 Ma, was largely abandoned following the creation of the Norwegian Sea spreading ridge, and with the exception of the Lofoten margin, there is subsequently little evidence for deformation passing into Fennoscandia. Renewal of modest compressional deformation in the Voering Basin suggest that the `Current Tectonic Regime` is of Quaternary age although the orientation of the major stress axis has remained consistent since around 10 Ma. The past pattern of changes suggest that in the geological near-future variations are to be anticipated in the magnitude rather than the orientation of stresses.

  4. Science Outreach for the Thousands: Coe College's Playground of Science

    Science.gov (United States)

    Watson, D. E.; Franke, M.; Affatigato, M.; Feller, S.

    2011-12-01

    Coe College is a private liberal arts college nestled in the northeast quadrant of Cedar Rapids, IA. Coe takes pride in the outreach it does in the local community. The sciences at Coe find enjoyment in educating the children and families of this community through a diverse set of venues; from performing science demonstrations for children at Cedar Rapids' Fourth of July Freedom Festival to hosting summer forums and talks to invigorate the minds of its more mature audiences. Among these events, the signature event of the year is the Coe Playground of Science. On the last Thursday of October, before Halloween, the science departments at Coe invite nearly two thousand children from pre elementary to high school ages, along with their parents to participate in a night filled with science demos, haunted halls, and trick-or-treating for more than just candy. The demonstrations are performed by professors and students alike from a raft of cooperative departments including physics, chemistry, biology, math, computer science, nursing, ROTC, and psychology. This event greatly strengthens the relationships between institution members and community members. The sciences at Coe understand the importance of imparting the thrill and hunger for exploration and discovery into the future generations. More importantly they recognize that this cannot start and end at the collegiate level, but the American public must be reached at younger ages and continue to be encouraged beyond the college experience. The Playground of Science unites these two groups under the common goal of elevating scientific interest in the American people.

  5. HUBBLE FINDS THOUSANDS OF GASEOUS FRAGMENTS SURROUNDING DYING STAR

    Science.gov (United States)

    2002-01-01

    Resembling a bizarre setting from a science fiction movie, dramatic images sent back by NASA's Hubble Space Telescope have surprised astronomers by uncovering thousands of gigantic tadpole-shaped objects surrounding a dying star. Dubbed 'cometary knots' because their glowing heads and gossamer tails superficially resemble comets, they are probably the result of a dying star's final outbursts. Though ground-based telescopic observations have hinted at such objects, they have not previously been seen in such abundance, say researchers. The knots were detected by Hubble astronomer C. Robert O'Dell and graduate student Kerry P. Handron of Rice University in Houston, Texas, while exploring the Helix nebula, a ring of glowing gases blown off the surface of a sunlike star late in its life. O'Dell expects the gaseous knots, which are each several billion miles across, will eventually dissipate and vanish into the cold emptiness of interstellar space. However, he speculates that if the objects contract to form permanent solid bodies, they may contribute to a fraction (less than ten percent) of the missing mass of our galaxy, simply because of their sheer abundance around a typical dying star. (This so-called dark matter is a known source of gravity that affects the motions of stars in the galaxy). The mysterious 'space pods' came into view as O'Dell used Hubble's Wide Field Planetary Camera 2 to survey the Helix nebula, located 450 light-years away in the constellation Aquarius and the closest planetary nebula to Earth -- so close that its angular size is almost half that of the full Moon. The most visible cometary knots all lie along the inner edge of the ring, at a distance of trillions of miles from the central star. Their comet-like tails, each stretching a hundred billion miles, form a radial pattern around the star like the spokes on a wagon wheel. Though previous ground-based observations show a spoke pattern in the Helix, and some structure, O'Dell emphasizes that

  6. Workshop Physics and Related Curricula: "A 25-Year History of Collaborative Learning Enhanced by Computer Tools for Observation and Analysis"

    Science.gov (United States)

    Laws, Priscilla W.; Willis, Maxine C.; Sokoloff, David R.

    2015-01-01

    This article describes the 25-year history of development of the activity-based Workshop Physics (WP) at Dickinson College, its adaptation for use at Gettysburg Area High School, and its synergistic influence on curricular materials developed at the University of Oregon and Tufts University and vice versa. WP and these related curricula: 1) are…

  7. Visual Thinking in Teaching History: Reading the Visual Thinking Skills of 12 Year-Old Pupils in Istanbul

    Science.gov (United States)

    Dilek, Gulcin

    2010-01-01

    This study aims to explore the visual thinking skills of some sixth grade (12-13 year-old) primary pupils who created visual interpretations during history courses. Pupils drew pictures describing historical scenes or events based on visual sources. They constructed these illustrations by using visual and written primary and secondary sources in…

  8. The natural history of Charcot-Marie-Tooth type 1A in adults: a 5-year follow-up study

    NARCIS (Netherlands)

    Verhamme, Camiel; van Schaik, Ivo N.; Koelman, Johannes H. T. M.; de Haan, Rob J.; de Visser, Marianne

    2009-01-01

    Charcot-Marie-Tooth type 1A is the most prevalent hereditary demyelinating polyneuropathy. The aim of this study was to investigate the natural history of the disease in adults during a 5-year follow-up and to compare the changes over time with those found in normal ageing. In a cohort of 46 adult

  9. One million years of glaciation and denudation history in west Greenland

    DEFF Research Database (Denmark)

    Strunk, Astrid; Knudsen, Mads Faurschou; Egholm, David L.

    2017-01-01

    The influence of major Quaternary climatic changes on growth and decay of the Greenland Ice Sheet, and associated erosional impact on the landscapes, is virtually unknown beyond the last deglaciation. Here we quantify exposure and denudation histories in west Greenland by applying a novel Markov...

  10. A Break with History : Fifteen Years of Inequality Reduction in Latin America

    OpenAIRE

    World Bank

    2011-01-01

    In 2004 the World Bank released a regional report titled 'Inequality in Latin America: Breaking with History?' Analyzing data from the early 1990s to the early 2000s, a period in which many countries in the region were experiencing increasing inequality, this study raised the question of whether Latin America could reverse its historical pattern of high and persistent inequality. The repor...

  11. Histories of Cyprus : the disputed years of Ottoman Rule 1571-1878

    OpenAIRE

    Smilden, Jan-Erik

    2007-01-01

    Summary Greek Cypriots and Turkish Cypriots have their respective versions of the history of Cyprus during the Ottoman rule from 1571 to 1878. This thesis examines how this period is presented and constructed by present Greek Cypriot and Turkish Cypriot historians.

  12. Genetic differentiation and spatial structure of Geosmithia morbida, the causal agent of thousand cankers disease in black walnut (Juglans nigra)

    Czech Academy of Sciences Publication Activity Database

    Hadziabdic, D.; Vito, L.; Windham, M. T.; Pscheidt, J. W.; Trigiano, R. N.; Kolařík, Miroslav

    2014-01-01

    Roč. 60, č. 2 (2014), s. 75-87 ISSN 0172-8083 Institutional support: RVO:61388971 Keywords : Thousand cankers disease * Juglans nigra * Geosmithia morbida Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.682, year: 2014

  13. Rewriting rural community and dictatorial history through magical realism in Márquez’s One Hundred Years of Solitude

    Directory of Open Access Journals (Sweden)

    Abdullah Abu Shahid

    2015-05-01

    Full Text Available Márquez was greatly influenced by his grandmother’s story-telling ability, and was highly indebted to the socio-political history of Latin America, particularly Colombia. In One Hundred Years of Solitude, he wants to reconstruct the lost world of childhood by using magical realism which gives expression to the world-view of a rural people who live in isolation from modern world. By retelling the official history from the perspective of the oppressed, he reveals the fact that history is never factual and impartial but serves the interest of those who write it. Through the banana company massacre and the subsequent hide and seek over the number of dead workers, Márquez exposes the way official history becomes fabricated and distorted by authorities, and fails to provide the original occurrences. He was disgusted with the political violence and civil wars which had distraught people; he was also against capitalism, scientific and technological inventions, and so-called modernization, which are the means through which foreign culture brings corruption and brutality, dominates, exploits and oppresses the natives, and threatens the native culture and identity. By employing magical realism, he was able to recreate Colombian history to protest against the way capitalism dominated the socio-political and economic structure of the region.

  14. Impacts and tectonism in Earth and moon history of the past 3800 million years

    Science.gov (United States)

    Stothers, Richard B.

    1992-01-01

    The moon's surface, unlike the Earth's, displays a comparatively clear record of its past bombardment history for the last 3800 Myr, the time since active lunar tectonism under the massive premare bombardment ended. From Baldwin's (1987) tabulation of estimated ages for a representative sample of large lunar craters younger than 3800 Ma, six major cratering episodes can be discerned. These six bombardment episodes, which must have affected the Earth too, appear to match in time the six major episodes of orogenic tectonism on Earth, despite typical resolution errors of +/- 100 Myr and the great uncertainties of the two chronologies. Since more highly resolved events during the Cenozoic and Mesozoic Eras suggest the same correlation, it is possible that large impacts have influenced plate tectonics and other aspects of geologic history, perhaps by triggering flood basalt eruptions.

  15. Receiver architecture of the thousand-element array (THEA)

    NARCIS (Netherlands)

    Kant, G.W.; Kokkeler, Andre B.J.; Smolders, A.B.; Gunst, A.W.

    2000-01-01

    As part of the development of a new international radio-telescope SKA (Square Kilometre Array), an outdoor phasedarray prototype, the THousand Element Array (THEA), is being developed at NFRA. THEA is a phased array with 1024 active elements distributed on a regular grid over a surface of

  16. 47 CFR 52.20 - Thousands-block number pooling.

    Science.gov (United States)

    2010-10-01

    ... aligned with any particular telecommunication industry segment, and shall comply with the same neutrality... 47 Telecommunication 3 2010-10-01 2010-10-01 false Thousands-block number pooling. 52.20 Section 52.20 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES...

  17. From hundreds to thousands: Widening the normal human Urinome

    Directory of Open Access Journals (Sweden)

    Laura Santucci

    2014-12-01

    The data are related to Santucci et al. (in press [1] and available both here and at ChorusProject.org under project name “From hundreds to thousands: widening the normal human Urinome”. The material supplied to Chorus Progect.org includes technical MS spectra data only.

  18. Testing Convergence Versus History: Convergence Dominates Phenotypic Evolution for over 150 Million Years in Frogs.

    Science.gov (United States)

    Moen, Daniel S; Morlon, Hélène; Wiens, John J

    2016-01-01

    Striking evolutionary convergence can lead to similar sets of species in different locations, such as in cichlid fishes and Anolis lizards, and suggests that evolution can be repeatable and predictable across clades. Yet, most examples of convergence involve relatively small temporal and/or spatial scales. Some authors have speculated that at larger scales (e.g., across continents), differing evolutionary histories will prevent convergence. However, few studies have compared the contrasting roles of convergence and history, and none have done so at large scales. Here we develop a two-part approach to test the scale over which convergence can occur, comparing the relative importance of convergence and history in macroevolution using phylogenetic models of adaptive evolution. We apply this approach to data from morphology, ecology, and phylogeny from 167 species of anuran amphibians (frogs) from 10 local sites across the world, spanning ~160 myr of evolution. Mapping ecology on the phylogeny revealed that similar microhabitat specialists (e.g., aquatic, arboreal) have evolved repeatedly across clades and regions, producing many evolutionary replicates for testing for morphological convergence. By comparing morphological optima for clades and microhabitat types (our first test), we find that convergence associated with microhabitat use dominates frog morphological evolution, producing recurrent ecomorphs that together encompass all sampled species in each community in each region. However, our second test, which examines whether and how much species differ from their inferred optima, shows that convergence is incomplete: that is, phenotypes of most species are still somewhat distant from the estimated optimum for each microhabitat, seemingly because of insufficient time for more complete adaptation (an effect of history). Yet, these effects of history are related to past ecologies, and not clade membership. Overall, our study elucidates the dominant drivers of

  19. The discovery of radium 100 years ago and the impact on the early history of nuclear science

    International Nuclear Information System (INIS)

    Adloff, J.P.

    1999-01-01

    One hundred years ago, Pierre and Marie Curie reawakened the topic of uranic rays and discovered two radioelements, polonium in July 1898 and radium in December. The circumstances of these events which announced the beginning of radiochemistry are reviewed at the light of the laboratory notebooks and the publications of the authors. The role of radium in the early history of radioactivity and nuclear sciences is emphasized. (author)

  20. The discovery of radium 100 years ago and the impact on the early history of nuclear science

    Energy Technology Data Exchange (ETDEWEB)

    Adloff, J.P. [University Louis Pasteur, 63 Rue Saint Urbain 67100 Strasbourg (France)

    1999-09-01

    One hundred years ago, Pierre and Marie Curie reawakened the topic of uranic rays and discovered two radioelements, polonium in July 1898 and radium in December. The circumstances of these events which announced the beginning of radiochemistry are reviewed at the light of the laboratory notebooks and the publications of the authors. The role of radium in the early history of radioactivity and nuclear sciences is emphasized. (author)

  1. [Martin Luther's somatic diseases. A short life-history 450 years after his death].

    Science.gov (United States)

    Iversen, O H

    1996-12-10

    The article contains a short life-history of the religious reformer Martin Luther (1483-1546) with main emphasis on his many somatic diseases. The list comprises varicose ulcer, angina pectoris with anxiety, obesity, hypertension arterialis, Ménière's disease with vertigo, tinnitus and fainting fits, gastralgia, constipation with anal ulcers and haemorrhoids with bleeding, urolithiasis, arthritis urica, Roemheld's syndrome, and cataract in one eye. Mentally he had a manic-depressive cast of personality, and a tendency to emotional lability. In spite of this he had an enormous capacity for work.

  2. A clinical procedures curriculum for undergraduate medical students: the eight-year history of a third-year immersive experience

    Directory of Open Access Journals (Sweden)

    Laura Thompson

    2016-05-01

    Full Text Available Background: Procedural skills training is a critical component of medical education, but is often lacking in standard clinical curricula. We describe a unique immersive procedural skills curriculum for medical students, designed and taught primarily by emergency medicine faculty at The Ohio State University College of Medicine. Objectives: The primary educational objective of this program was to formally introduce medical students to clinical procedures thought to be important for success in residency. The immersion strategy (teaching numerous procedures over a 7-day period was intended to complement the student's education on third-year core clinical clerkships. Program design: The course introduced 27 skills over 7 days. Teaching and learning methods included lecture, prereading, videos, task trainers, peer teaching, and procedures practice on cadavers. In year 4 of the program, a peer-team teaching model was adopted. We analyzed program evaluation data over time. Impact: Students valued the selection of procedures covered by the course and felt that it helped prepare them for residency (97%. The highest rated activities were the cadaver lab and the advanced cardiac life support (97 and 93% positive endorsement, respectively. Lectures were less well received (73% positive endorsement, but improved over time. The transition to peer-team teaching resulted in improved student ratings of course activities (p<0.001. Conclusion: A dedicated procedural skills curriculum successfully supplemented the training medical students received in the clinical setting. Students appreciated hands-on activities and practice. The peer-teaching model improved course evaluations by students, which implies that this was an effective teaching method for adult learners. This course was recently expanded and restructured to place the learning closer to the clinical settings in which skills are applied.

  3. Uniform Supersonic Chemical Reactors: 30 Years of Astrochemical History and Future Challenges.

    Science.gov (United States)

    Potapov, Alexey; Canosa, André; Jiménez, Elena; Rowe, Bertrand

    2017-07-17

    The interstellar medium is of great interest to us as the place where stars and planets are born and from where, probably, the molecular precursors of life came to Earth. Astronomical observations, astrochemical modeling, and laboratory astrochemistry should go hand in hand to understand the chemical pathways to the formation of stars, planets, and biological molecules. We review here laboratory experiments devoted to investigations on the reaction dynamics of species of astrochemical interest at the temperatures of the interstellar medium and which were performed by using one of the most popular techniques in the field, CRESU. We discuss new technical developments and scientific ideas for CRESU, which, if realized, will bring us one step closer to understanding of the astrochemical history and the future of our universe. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. The Hospital de Santiago in Cuenca: an institution with 800 years history

    Directory of Open Access Journals (Sweden)

    Julián Solís García del Pozo

    2018-04-01

    Full Text Available The Hospital de Santiago in the city of Cuenca is one of the Spanish healthcare institutions that has maintained its activity for a longer time. Initially, this hospital was an institution for the redemption of captives in a border area of the kingdom of Castile with Al-Andalus, later it functioned as a hospital for the sick poor, maintaining its assistance activity despite the different destructions that the building has gone throughout its history. Currently, the hospital is a geriatric residence. Historical studies on hospitals have extended their scope of action, leaving the particular scope of institutional functioning and entering into areas as the hospital's relationship with the political, religious, social and economic environment. From this point of view, the hospital in Cuenca is still a little-explored ground to study these relationships in a city in interior Spain during a large part of the historical stages it has gone through, and especially from the Modern Age.

  5. 500-year periodicity of political instability in the history of ancient Egypt and China. Androgens at work?

    Science.gov (United States)

    Páles, Emil; Mikulecký, Miroslav

    2008-08-01

    DISCOVERY: A periodicity of 500 years has been discovered in the political history of ancient Egypt and documented by means of inferential statistics. Periods of chaos and waning of central power (some of them called "intermediate periods") recurred every 500 years. Input for the computation is the mean duration of ruling dynasties calculated per each half century. Fisher's periodogram analysis and Halberg's cosinor regression have been used. A highly significant (p ancient Egypt as well as China between 3000 and 500 B. C. culminated each 500 years synchronously. No local events, confined to Egypt or China alone, can serve as an explanation. The rhythm of "dark ages" seems to continue beyond Egyptian and ancient Chinese history into the modern era and seems to be world-wide. It is a surprising fact, that this periodicity has been known already to the priests of Babylon, who ascribed this to the maleficient influence of god Nergal. The same periodicity has been described by the Chinese philosopher Mencius in the 3rd century B.C. and attributed to the will of tian (heaven). Egyptians elevated their war god Seth every 500 years and European kings assumed masculine nicknames. This recurring cultural pattern of aggressiveness and strife resembles overall traits of male psyche or mid-life crisis. We suggest to look for an unknown cosmophysical factor impacting the neuroendocrine system of man by raising the levels of androgens periodically. EXPLANATION HYPOTHESES: Sun impacts global weather on Earth, but there is no known significant periodicity of 500 years in solar activity. The Wheeler weather cycle almost fits the cycle of Egyptian political history. But his cold-dry periods seem to lag behind the periods of social destabilization and hence can not cause them. An alternative view (based on idealistic rather than materialistic presuppositions) is, that periodic long-term shifts of archetypes take place within the collective unconscious of mankind independently of

  6. Revegetation after strip cutting and block clearcutting in northern hardwoods: a 10-year history

    Science.gov (United States)

    C. Wayne Martin; Hornbeck James W.; Hornbeck James W.

    1989-01-01

    Changes in the density and biomass of trees, shrubs, and herbs were measured periodically over 10 years following a progressive strip cutting and block clearcutting of northern hardwoods. At 10 years after clearcutting, yellow birch was the most numerous commercial or uncommercial tree on the block clearcut; sugar maple on the strip cut. Pin cherry dominated the...

  7. China's brick history and conservation

    DEFF Research Database (Denmark)

    Shu, C. X.; Cantisani, E.; Fratini, F.

    2017-01-01

    . This study focuses on Shanghai as a representative city in that transitional period, aims at addressing the true condition of the modern changes in China's brick history and the heritage today. The paper presents the first results of an interdisciplinary investigation. Fourteen brick samples and one sample......Fired bricks have been used for construction purposes in China for at least two thousand years. Since the mid-19th century the manufacture of bricks has shifted from an old to a new system. The unique Chinese blue brick has been gradually replaced by the European red brick and other modern products...

  8. Language outcomes of 7-year-old children with or without a history of late language emergence at 24 months.

    Science.gov (United States)

    Rice, Mabel L; Taylor, Catherine L; Zubrick, Stephen R

    2008-04-01

    The aim of this study was to investigate the language outcomes of 7-year-old children with and without a history of late language emergence at 24 months. One hundred twenty-eight children with a history of late language emergence (LLE) at 24 months and 109 children with a history of normal language emergence (NLE) at 24 months participated in direct behavioral assessment of multiple dimensions of language at 7 years. The children were recruited from a prospective cohort study of 1,766 epidemiologically ascertained 24-month-old singleton children. The group mean for the LLE children was within the typical range on an omnibus measure of general language ability and measures of specific dimensions of language. However, a greater percentage of LLE children, relative to NLE children, performed below normative expectations on a measure of general language ability (20% versus 11%), speech (7% versus 2%), syntax (18% versus 8%), and morphosyntax (9%-23% versus 2%-14%), but not vocabulary or semantics. The results provide support for growth models of language impairment that predict that late onset of language foretells a protracted growth difference for some LLE children relative to NLE children, particularly for syntax and morphosyntax.

  9. Publication trends for articles related to the history of anesthesia: a 10-year analysis from six journals.

    Science.gov (United States)

    Mulita, Avenir; Liu, Xiaoxia; Desai, Sukumar P

    2013-04-01

    Anesthesia historians believe they have difficulty in getting their work published in peer reviewed journals devoted to anesthesiology. To test the hypothesis of whether such publication bias exists, we conducted a review of all articles published in six journals. We examined all articles published between January 2001 and December 2010. In order to enable comparison among journals, articles were categorized as major or minor. We also examined whether there were trends in publication over this period. During this 10-year period, 30,600 articles were published in these journals (range, 2573 to 8563 articles). Of all articles published, only 382 (1.25%, range, 0.41% to 2.87%) were related to the history of anesthesia. The proportion of all articles related to history showed a significant difference with time (Particles (Particles published shows no obvious difference over the 10-year period (P=.25), but a significant difference among journals (P=.005). For major articles, there was a significant effect with time (P=.046) and journal (Particles revealed no significant effect with time (P=.15), but significant differences among journals (P=.02). Our analysis of 30,600 articles published in six mainstream journals devoted to anesthesiology found that considerable differences exist in the proportion and number of articles that were related to history of anesthesia.

  10. Parental depressive history, parenting styles, and child psychopathology over six years: The contribution of each parent’s depressive history to the other’s parenting styles

    OpenAIRE

    Kopala-Sibley, Daniel C.; Jelinek, Caitlin; Kessel, Ellen; Frost, Allison; Allmann, Anna E.S.; Klein, Daniel N.

    2017-01-01

    The link between parental depressive history and parenting styles is well established, as is the association of parenting with child psychopathology. However, little research has examined whether a depressive history in one parent predicts the parenting style of the other parent. As well, relatively little research has tested transactional models of the parenting-child psychopathology relationship in the context of parents’ depressive histories. In this study, mothers and fa...

  11. The Atomic Testing Museum: Presenting the History and Preservation of a 50 Year Journey

    International Nuclear Information System (INIS)

    Troy E, Wade II

    2009-01-01

    The Nevada Test Site (NTS) is one of the premier test and evaluation sites belonging to the National Nuclear Security Administration (NNSA), a part of the Department of Energy. Founded in 1950, it is a major domestic location for the testing of nuclear components and nuclear weapons destined for the stockpile, the nuclear deterrent of the United States. From 1951 until 1992 there were 100 atmospheric and 828 underground nuclear tests conducted at the NTS. Those tests resulted in the development of a nuclear deterrent that helped prevent a world war and played a major role in the final defeat of the Soviet Union in the Cold War. Those tests lead to the development of yield measurement techniques that allowed the United States Government to take the lead in the negotiations of the Comprehensive Nuclear Test Ban Treaty (CTBT), which took effect in 1992, ending the requirement to do routine nuclear tests. This paper describes the walk through the history of the NTS' Cold War battlefield. (authors)

  12. Reproductive history, socioeconomic status and disability in the women aged 65 years or older in Turkey.

    Science.gov (United States)

    Akin, Belgin; Ege, Emel; Koçoğlu, Deniz; Arslan, Selda Y; Bilgili, Naile

    2010-01-01

    Pregnancy and childbirth are an important physiological and emotional phenomenon in their lives for most women and studies have shown that this process may have a significant impact on their health at later ages. The objective of the study is to examine the relationship between functional disabilities in women over the age of 65 and their reproductive history and socioeconomic status. This is a cross-sectional study. The study group consisted of 543 women aged 65 or over. A general questionnaire and the Brief Disability Questionnaire (BDQ) were used to collect data with face-to-face interview in home visits. Of the women 79.2% have disability. First childbirth was experienced at the average age of 19.6+/-3.3 and the average age at which the women experienced their last delivery was 32.5+/-6.3. Parity was 4.1+/-1.7. Advanced age, being widowed and illiterate, less income, being outside of the middle class and having more than four children are important determinants for later life disability. The study highlights the importance of focusing not just on the short-term effects of childbearing and socioeconomic factors, but also of taking into account the possibility of long-term effects on disability in older women.

  13. Prolonged Unilateral Disuse Osteopenia 14 Years Post External Fixator Removal: A Case History and Critical Review

    Directory of Open Access Journals (Sweden)

    Karen M. Knapp

    2010-01-01

    Full Text Available Disuse osteopenia is a complication of immobilisation, with reversal generally noted upon remobilisation. This case report focuses on a patient who was seen 18 years following a road traffic collision when multiple fractures were sustained. The patient had an external fixator fitted for a tibia and fibula fracture, which remained in situ for a period of 4 years. Following removal, the patient was mobilised but, still required a single crutch to aid walking. Fourteen years post removal of the fixator, the patient had a DXA scan which, demonstrated a T-score 2.5 SD lower on the affected hip. This places the patient at an increased risk of hip fracture on this side, which requires monitoring. There appear to be no current studies investigating prolonged disuse-osteopenia in patients following removal of long-term external fixators. Further research is required to quantify unilateral long-term effects to bone health and fracture risk in this population.

  14. Twenty years of the journal of product innovation management : History, participants and knowledge stock and flows

    NARCIS (Netherlands)

    Moenaert, R.K.; Griffin, A.; Biemans, W.

    2007-01-01

    The Journal of Product Innovation Management (JPIM) serves as a marketplace for science-based, innovative ideas that are produced and consumed by scholars and businesspeople. Now that JPIM has existed for 20 years, two intriguing questions emerge: (1) How has the journal evolved over time in terms

  15. The history of fifty years of institute of electrical engineers 1947-1996

    International Nuclear Information System (INIS)

    1997-07-01

    This book starts with the survey of a century of Korea electrical industry. It includes a business of electric power and electrical machinery industry. Next, it deals with the survey of fifty years of Korea institute electrical engineers. Then, it enumerates the articles of association, organization, board members, the role of the administrative organization, study and institute business activities in detail.

  16. Twenty years of the Journal of product innovation management : History, participants, and knowledge stock and flows

    NARCIS (Netherlands)

    Biemans, Wim; Griffin, Abbie; Moenaert, Rudy

    The Journal of Product Innovation Management (JPIM) serves as a marketplace for science-based, innovative ideas that are produced and consumed by scholars and businesspeople. Now that JPIM has existed for 20 years, two intriguing questions emerge: (1) How has the journal evolved over time in terms

  17. Natural history of hip instability in infants (without subluxation or dislocation): a three year follow-up.

    Science.gov (United States)

    Pruszczynski, Blazej; Harcke, H Theodore; Holmes, Laurens; Bowen, J Richard

    2014-10-28

    The natural history of hip instability (without subluxation or dislocation) and treatment in infants remain controversial. We performed a retrospective cohort case-only study with blinded, prospectively collected data to assess normalization of the acetabular index in consecutive untreated infant hips with sonography instability. Consecutive hips meeting inclusion criteria were followed by sonography/radiography and data analyzed using tabular and regression models. In 48 hips, acetabular index measured by radiography normalized within 3 years of age without treatment. Normalization by age occurred: 7 months in 35%, 12 months in 67%, 18 months in 75%, 24 months in 81%, and 36 months in 100%. Two patterns of normalization of the acetabular index were observed: group I showed ossification in a physiological range of normal by 7 months of age, and group II had delayed ossification with later normalization of the acetabular index measurement. Breech presentation (p =0.013) and cesarean delivery (p =0.004) statistically directly correlated with a later normalization. The natural history of infant hip instability (without subluxation or dislocation), which is reduced at rest and unstable with stress as diagnosed by the Harcke method of sonography, has spontaneous normalization of the acetabular index within 3 years of age. We suggest three patterns of acetabular ossification in unstable infants' hips: (I) normal ossification, (II) delayed ossification with normalization of the acetabular index by age 3 years, and (III) defective secondary centers of ossification with an upward tilt of the lateral acetabular rim in adolescence.

  18. Vegetation history and human impact during the last 300 years recorded in a German peat deposit

    OpenAIRE

    van der Linden, M.; Vickery, E.; Charman, D.J.; Broekens, P.; van Geel, B.

    2008-01-01

    A peat core from the Barschpfuhl kettlehole mire in north-east Germany was analysed for multiproxy indicators (plant macrofossils, pollen/non-pollen microfossils, testate amoebae, colorimetric humification, carbon/nitrogen ratios, bulk density, loss on ignition), to investigate the effects of climate change and human impact on vegetation and peat accumulation during the last c. 300 years. 14C wiggle-match dating was applied for high-precision dating. Testate amoebae assemblages were used to r...

  19. 40 years of progress in NDT - History as a guide to the future

    Energy Technology Data Exchange (ETDEWEB)

    Farley, Mike [Chairman, International Committee for NDT (ICNDT) and Secretariat: The British Institute of NDT, Newton Building, St George' s Avenue, Northampton NN2 6JB (United Kingdom)

    2014-02-18

    The paper is focussed on the progress which has been made over 40 years in the science, technology and application of NDT/NDE both during manufacture and in-service, from the perspective of the author and his background in the energy industries in the UK. New techniques not dreamt of 40 years ago and new technology such as personal computers, lasers and robotics which are now common-place in everyday life have transformed some aspects of NDT. But other aspects have remained unchanged, including the continued use of the more basic NDT methods and the challenges of recruitment, training, certification and motivation of personnel. There have been major changes in the world scene over 40 years including the globalization of trade, the emergence of new countries as industrial powers, and the ageing of safety critical infrastructure. These have impacted on NDT business and on the activities of the international NDT community (including ICNDT, the International Committee for NDT). The paper concludes by introducing the activities championed by ICNDT to promote the understanding of the importance of NDT, to support the development of NDT Societies around the world, to educate users on the correct use of personnel certification and to pursue the objective of global harmonisation and recognition of third party certification.

  20. 40 years of progress in NDT - History as a guide to the future

    Science.gov (United States)

    Farley, Mike

    2014-02-01

    The paper is focussed on the progress which has been made over 40 years in the science, technology and application of NDT/NDE both during manufacture and in-service, from the perspective of the author and his background in the energy industries in the UK. New techniques not dreamt of 40 years ago and new technology such as personal computers, lasers and robotics which are now common-place in everyday life have transformed some aspects of NDT. But other aspects have remained unchanged, including the continued use of the more basic NDT methods and the challenges of recruitment, training, certification and motivation of personnel. There have been major changes in the world scene over 40 years including the globalization of trade, the emergence of new countries as industrial powers, and the ageing of safety critical infrastructure. These have impacted on NDT business and on the activities of the international NDT community (including ICNDT, the International Committee for NDT). The paper concludes by introducing the activities championed by ICNDT to promote the understanding of the importance of NDT, to support the development of NDT Societies around the world, to educate users on the correct use of personnel certification and to pursue the objective of global harmonisation and recognition of third party certification.

  1. 40 years of progress in NDT - History as a guide to the future

    International Nuclear Information System (INIS)

    Farley, Mike

    2014-01-01

    The paper is focussed on the progress which has been made over 40 years in the science, technology and application of NDT/NDE both during manufacture and in-service, from the perspective of the author and his background in the energy industries in the UK. New techniques not dreamt of 40 years ago and new technology such as personal computers, lasers and robotics which are now common-place in everyday life have transformed some aspects of NDT. But other aspects have remained unchanged, including the continued use of the more basic NDT methods and the challenges of recruitment, training, certification and motivation of personnel. There have been major changes in the world scene over 40 years including the globalization of trade, the emergence of new countries as industrial powers, and the ageing of safety critical infrastructure. These have impacted on NDT business and on the activities of the international NDT community (including ICNDT, the International Committee for NDT). The paper concludes by introducing the activities championed by ICNDT to promote the understanding of the importance of NDT, to support the development of NDT Societies around the world, to educate users on the correct use of personnel certification and to pursue the objective of global harmonisation and recognition of third party certification

  2. A 10-year review of the dose history of radiation workers in the University of Surrey

    International Nuclear Information System (INIS)

    Parami, V.K.

    1991-09-01

    This thesis presents data on internally and externally received doses for radiation workers whose records are kept at the Safety Office of the University of Surrey for the period 1981-1990. The distribution of doses by range is presented and analysed. The patterns of the collective equivalent dose (CED) and the average individual equivalent dose (IED) over the 10-year period are presented. The annual CED is very low, so that even the total for the 10-year period is less than 1 man-Sv. Likewise, the annual average IED is extremely low, well below the average annual dose to the U.K. population from overall sources of ionising radiation. Some relevant aspects of the 1990 ICRP Recommendations are examined and the impact of these to the 'practices' and sources of ionising radiation in the University is given consideration. The results of the 10-year review provide more evidence of over designation of radiation workers in the University. A recommendation is made to reduce the number of workers who are routinely monitored and justification and options are presented. This study is viewed as a useful database which could be of particular importance in the procedure of optimisation of radiation protection in the University of Surrey and U.K. establishments for higher education as a whole. (author)

  3. Climate history at Aurora Basin North, East Antarctica: A 2,000 year isotopic record

    Science.gov (United States)

    Moy, Andrew; van Ommen, Tas; McConnel, Joe; Curran, Mark; Phipps, Steven; Masson-Delmotte, Valérie; Orsi, Anaïs; Touzeau, Alexandra; Roberts, Jason; Dahl-Jensen, Dorthe; Popp, Trevor; Svensson, Anders; Landais, Amaelle; Vance, Tessa; Liu, Yaping; Arienzo, Monica

    2017-04-01

    In Antarctica, a reasonable coverage of ice core records exist for the last couple of hundred years, however there is poor spatial coverage of high-resolution climate data over the last 2000 years, particularly from East Antarctica (EA). The aim of the Aurora Basin North (ABN) ice core drilling project is to provide a 2000 year climate record from a data sparse area of EA to add to the IPICS 2k array and the PAGES Antarctica2k projects. ABN is a 303m ice core from EA, 550km inland and about half way between the coastal Law Dome and inland Dome C sites. Contiguous measurements of water stable isotope ratios (d18O and dD) have been performed along the entire length of the ABN ice core and provides a climate record at seasonal to decadal resolution for this region of EA spanning the past 2000 years. The isotopic variability at ABN shows clear annual cycles in the upper 50 m and longer-term variability on decadal to centennial timescales. The ABN record shows no long-term isotopic trend over the 2,000 year record length, similar to the four isotopic ice core records used in EA for the PAGES Antarctic 2k temperature reconstruction (PAGES2k, 2013). Mean ABN isotopic values (d18O -40.70 per mille, and dD -321.1 per mille) fall along the modern Antarctic spatial isotope/elevation and isotope/distance from the ocean relationships. The second order isotope parameter, deuterium excess (d) displays a relatively stable record (mean value of 4.4 per mille), with occasional sharp transitions to values as high as 8-10 per mille and as low as 0-1 per mille =. The large deuterium excess variations may reflect changes in moisture origin and evaporation conditions (SST, relative humidity). The isotopic variability at ABN therefore potentially reflects a mix of changes in transport and local climate (acting on precipitation intermittency and distillation strength), as well as local elevation changes. A comparison of the preliminary dated ABN isotope record with the Law Dome isotopic

  4. Modern history of women in sports. Twenty-five years of Title IX.

    Science.gov (United States)

    Lopiano, D A

    2000-04-01

    The impact of federal anti-discrimination laws such as Title IX and the Amateur Sports Act have opened the doors of sport participation opportunity to girls and women in sports over the last 25 years. Such participation has created new and more lucrative consumer markets for sporting goods manufactures, as well as college and professional sports teams. The prospect of economic gain has created significant social changes: Women are now being encouraged to participate in sports and embrace the resulting benefits, and the general public is showing increased support for gender equity in sports.

  5. The history of healthcare quality: The first 100 years 1860–1960

    Directory of Open Access Journals (Sweden)

    Brenda Helen Sheingold

    2014-01-01

    Full Text Available In the 21st Century, health care systems across the world are focusing policy efforts on improving the quality of healthcare delivered to their population. In contrast, healthcare quality improvement in earlier time periods arose from a series of seemingly unrelated incidents and developments. In this paper, we sequentially review key international historical events that improved health care quality during the years 1860–1960, including innovation in health care financing, care delivery and workforce diversity. The modern nursing workforce of today continues to encounter many of these same challenges across the globe.

  6. 35Year Research History of Cytotoxicity and Cancer: a Quantitative and Qualitative Analysis.

    Science.gov (United States)

    Farghadani, Reyhaneh; Haerian, Batoul Sadat; Ebrahim, Nader Ale; Muniandy, Sekaran

    2016-01-01

    Cancer is the leading cause of morbidity and mortality worldwide, characterized by irregular cell growth. Cytotoxicity or killing tumor cells that divide rapidly is the basic function of chemotherapeutic drugs. However, these agents can damage normal dividing cells, leading to adverse effects in the body. In view of great advances in cancer therapy, which are increasingly reported each year, we quantitatively and qualitatively evaluated the papers published between 1981 and December 2015, with a closer look at the highly cited papers (HCPs), for a better understanding of literature related to cytotoxicity in cancer therapy. Online documents in the Web of Science (WOS) database were analyzed based on the publication year, the number of times they were cited, research area, source, language, document type, countries, organizationenhanced and funding agencies. A total of 3,473 publications relevant to the target key words were found in the WOS database over 35 years and 86% of them (n=2,993) were published between 20002015. These papers had been cited 54,330 times without self citation from 1981 to 2015. Of the 3,473 publications, 17 (3,557citations) were the most frequently cited ones between 2005 and 2015. The topmost HCP was about generating a comprehensive preclinical database (CCLE) with 825 (23.2%) citations. One third of the remaining HCPs had focused on drug discovery through improving conventional therapeutic agents such as metformin and ginseng. Another 33% of the HCPs concerned engineered nanoparticles (NPs) such as polyamidoamine (PAMAM) dendritic polymers, PTX/SPIOloaded PLGAs and cell derived NPs to increase drug effectiveness and decrease drug toxicity in cancer therapy. The remaining HCPs reported novel factors such as miR205, Nrf2 and p27 suggesting their interference with development of cancer in targeted cancer therapy. In conclusion, analysis of 35year publications and HCPs on cytotoxicity in cancer in the present report provides opportunities for

  7. One hundred and fifty years of Coulomb stress history along the California-Nevada border, USA

    Science.gov (United States)

    Verdecchia, Alessandro; Carena, Sara

    2015-02-01

    The region north of the Garlock Fault between the Sierra Nevada and Death Valley has experienced at least eight Mw ≥ 6 earthquakes in historical times, beginning with the 1872, Mw 7.5, Owens Valley earthquake. Furthermore, since 1978, the Long Valley Caldera has been undergoing periods of unrest, with earthquake swarms and resurgence. Our goal is to determine whether the 1872 Owens Valley earthquake and the caldera unrest have influenced the evolution of seismicity in the area. We model the evolution of coseismic, postseismic, and interseismic Coulomb stress change (Coulomb failure stress (ΔCFS)) in the region due to both Mw ≥ 6 earthquakes and caldera inflation in the last 150 years. Our results show that the 1872 Owens Valley earthquake has an important influence on subsequent events, strongly encouraging faulting in northern Owens Valley while inhibiting it elsewhere. There is also a correlation between caldera inflation and seismicity in northern Owens Valley, evidenced by the west-to-east migration of earthquakes from the Long Valley Caldera toward the White Mountains immediately following the 1978 caldera inflation event. Finally, we show that a total ΔCFS increase of up to 30 bars in the last 150 years has occurred on part of the White Mountains fault, making it a possible candidate for the next major earthquake in this region.

  8. Association of American Veterinary Medical Colleges (AAVMC): 50 Years of History and Service.

    Science.gov (United States)

    Maccabe, Andrew T; Crawford, Lester; Heider, Lawrence E; Hooper, Billy; Mann, Curt J; Pappaioanou, Marguerite

    2015-01-01

    The mission of the Association of American Veterinary Medical Colleges (AAVMC) is to advance the quality of academic veterinary medicine. Founded in 1966 by the 18 US colleges of veterinary medicine and 3 Canadian colleges of veterinary medicine then in existence, the AAVMC is celebrating 50 years of public service. Initially, the AAVMC comprised the Council of Deans, the Council of Educators, and the Council of Chairs. In 1984, the tri-cameral structure was abandoned and a new governing structure with a board of directors was created. In 1997, the AAVMC was incorporated in Washington, DC and a common application service was created. Matters such as workforce issues and the cost of veterinary medical education have persisted for decades. The AAVMC is a champion of diversity in the veterinary profession and a strong advocate for One Health. The AAVMC has adopted a global perspective as more international colleges of veterinary medicine have earned COE accreditation and become members.

  9. Urinary incontinence persisting after childbirth: extent, delivery history, and effects in a 12-year longitudinal cohort study.

    Science.gov (United States)

    MacArthur, C; Wilson, D; Herbison, P; Lancashire, R J; Hagen, S; Toozs-Hobson, P; Dean, N; Glazener, C

    2016-05-01

    To investigate the extent of persistent urinary incontinence (UI) 12 years after birth, and association with delivery-mode history and other factors. Twelve-year longitudinal cohort study. Maternity units in Aberdeen, Birmingham, and Dunedin. Women who returned questionnaires 3 months and 12 years after index birth. Data on all births over a period of 12 months were obtained from the units and then women were contacted by post. Persistent UI reported at 12 years, with one or more previous contact. Of 7879 women recruited at 3 months, 3763 (48%) responded at 12 years, with 2944 also having responded at 6 years; non-responders had similar obstetric characteristics. The prevalence of persistent UI was 37.9% (1429/3763). Among those who had reported UI at 3 months, 76.4% reported it at 12 years. Women with persistent UI had lower SF12 quality of life scores. Compared with having only spontaneous vaginal deliveries (SVDs), women who delivered exclusively by caesarean section were less likely to have persistent UI (odds ratio, OR 0.42, 95% CI 0.33-0.54). This was not the case in women who had a combination of caesarean section and SVD births (OR 1.01, 95% CI 0.78-1.30). Older age at first birth, greater parity, and overweight/obesity were associated with persistent UI. Of 54 index primiparae with UI before pregnancy, 46 (85.2%) had persistent UI. This study, demonstrating that UI persists to 12 years in about three-quarters of women, and that risk was only reduced with caesarean section if women had no other delivery mode, has practice implications. A longitudinal study of 3763 women showed a prevalence of persistent UI 12 years after birth of 37.9%. © 2015 Royal College of Obstetricians and Gynaecologists.

  10. A 300-year history of Pacific Northwest windstorms inferred from tree rings

    Science.gov (United States)

    Knapp, Paul A.; Hadley, Keith S.

    2012-07-01

    Hurricane-force winds are frequently allied with mid-latitude cyclones yet little is known about their historical timing and geographic extent over multiple centuries. This research addresses these issues by extending the historical record of major mid-latitude windstorms along North America's Pacific Northwest (PNW) coast using tree-ring data collected from old-growth (> 350 years), wind-snapped trees sampled at seven coastal sites in Oregon, USA. Our objectives were to: 1) characterize historical windstorm regimes; 2) determine the relationship between high-wind events (HWEs) and phases of the PDO, ENSO and NPI; and 3) test the hypothesis that PNW HWEs have migrated northward. We based our study on the identification of tree-growth anomalies resulting from windstorm-induced canopy changes corresponding to documented (1880-2003) and projected HWEs (1701-1880). Our methods identified all major windstorm events recorded since the late 1800s and confirmed that variations in coastal tree-growth are weakly related to temperature, precipitation, and drought, but are significantly related to peak wind speeds. These results suggest wind-induced changes in canopy conditions control tree growth at all sites. Comparisons between the tree-ring record and the PDO, NPI, and ENSO revealed a significant positive correlation between HWEs and neutral to warm PDO conditions and a slightly weaker correlation with the NPI. ENSO events were not significantly related to the occurrence of HWEs. Latitudinal groupings of our sites revealed a gradual and non-significant northerly shift of HWEs until the late 19th century followed by a significant northward shift during the past 120 years. These results mark the application of dendroanemology as a method for characterizing windstorm regimes for multiple centuries.

  11. A History of the Environmental Management Advisory Board: 20 Years of Service and Partnership - 13219

    International Nuclear Information System (INIS)

    Ellis, Kristen; Schmitt, Elizabeth

    2013-01-01

    The Environmental Management Advisory Board (EMAB or Board) was chartered under the Federal Advisory Committee Act (FACA) in 1992 to provide the Assistant Secretary for Environmental Management (EM) with independent and external advice, information, and recommendations on corporate issues relating to accelerated site clean-up and risk reduction throughout the EM complex. Over the course of the past 20 years, the composition and focus of the Board have varied widely to address the changing needs of the program. EMAB began as the Environmental Restoration and Waste Management Advisory Committee, formed to provide advice on an EM Programmatic Environmental Impact Statement. In 1994, the Board was restructured to function more as an executive-level, limited member advisory board whose membership provides insight of leading industry experts and the viewpoints of representatives from critical stakeholder constituencies. Throughout the 20 years of its existence, EMAB has covered a wide variety of topics and produced nearly 200 recommendations. These recommendations have resulted in several policy changes and improvements within EM. Most recently, EMAB has been credited for its contribution to the EM Energy Park Initiative, forerunner of the DOE Asset Revitalization Initiative; creation of the EM Offices of Communications and External Affairs; improvement of acquisition and project management strategies and culture; and several recommendations related to the Waste Treatment Plant and the tank waste programs at Hanford and the Savannah River Site. The wealth of experience and knowledge the Assistant Secretary can leverage through utilization of the Board continues to support fulfillment of EM's mission. In commemoration of EMAB's 20. anniversary, this paper will provide further context for the evolution of the Board, the role FACA plays in its administration, and a look at the members' current objectives and EM's expectations for the future. (authors)

  12. A personal perspective: 100-year history of the humoral theory of transplantation.

    Science.gov (United States)

    Terasaki, Paul I

    2012-04-27

    The humoral theory states that antibodies cause the rejection of allografts. From 1917 to 1929, extensive efforts were made to produce antibodies against tumors. It was finally realized that the antibodies were produced against the transplant antigens present on transplantable tumors, not against the tumor-specific antigens. To get around this problem, inbred mouse strains were developed, leading to identification of the transplant antigens determined by the H-2 locus of mice. The antibodies were hemagglutinating and cytotoxic antibodies. The analogous human leukocyte antigen system was established by analysis of lymphocytotoxic alloantibodies that were made by pregnant women, directed against mismatched antigens of the fetus. The human leukocyte antigen antibodies were then found to cause hyperacute rejection, acute rejection, and chronic rejection of kidneys. Antibodies appeared in almost all patients after rejection of kidneys. With Luminex single antigen bead technology, donor-specific antibodies could be identified before rise in serum creatinine and graft failure. Antibodies were shown to be predictive of subsequent graft failure in kidney, heart, and lung transplants: patients without antibodies had superior 4-year graft survival compared with those who did have antibodies. New evidence that antibodies are also associated with chronic failure has appeared for liver and islet transplants. Four studies have now shown that removal or reduction of antibodies result in higher graft survival. If removal of antibodies prevents chronic graft failure, final validation of the humoral theory can be achieved.

  13. Dentition and Life History of a 16-year-old Known-age Free-living Male Lion Panthera leo (Linnaeus, 1758 from the Kruger National Park

    Directory of Open Access Journals (Sweden)

    I.J. Whyte

    1988-10-01

    Full Text Available Wear in the dentition of a known-age, free-living, 16-year-old male lion is described and compared to existing age-determination techniques. Aspects of his life history are described as they are in some contrast to what is known of male lions' life history strategies.

  14. 2000 Years of Grazing History and the Making of the Cretan Mountain Landscape, Greece.

    Directory of Open Access Journals (Sweden)

    Isabelle Jouffroy-Bapicot

    Full Text Available Understanding the processes that led to the recent evolution of Mediterranean landscapes is a challenging question that can be addressed with paleoecological data. Located in the White Mountains of Crete, Asi Gonia peat bog constitutes an exceptional 2000-years-long sedimentary archive of environmental change. In this study, we document the making of the White Mountains landscape and assess human impact on ecosystem trajectories. The paleoenvironmental reconstruction is based on high-resolution analyses of sediment, pollen, dung fungal spores and charcoal obtained from a 6-m core collected from the bog. Multiproxy analyses and a robust chronological control have shed light on anthropogenic and natural processes that have driven ecological changes, giving rise to the present-day Mediterranean ecosystem. Our results suggest that sediment accumulation began during the transition from the Hellenistic to the Roman period, likely due to watershed management. The evolution of the peat bog as well as vegetation dynamics in the surrounding area were linked to past climate changes but were driven by human activities, among which breeding was of great importance. Charcoal analysis reveals that fire was largely used for the construction and maintenance of sylvo-agropastoral areas. Pollen data allow the identification of three main vegetation assemblages: 1 evergreen oak forest (before ca. 850 AD, 2 heather maquis (ca. 850 to 1870 AD, 3 phrygana/steppe landscape. Rapid changes between phases in vegetation development are associated with tipping-points in ecosystem dynamics resulting from anthropogenic impact. The modern ecosystem did not get established until the 20th century, and it is characterized by biodiversity loss along with a dramatic drying of the peat bog.

  15. Climatic history of the northeastern United States during the past 3000 years

    Science.gov (United States)

    Marlon, Jennifer R.; Pederson, Neil; Nolan, Connor; Goring, Simon; Shuman, Bryan; Robertson, Ann; Booth, Robert; Bartlein, Patrick J.; Berke, Melissa A.; Clifford, Michael; Cook, Edward; Dieffenbacher-Krall, Ann; Dietze, Michael C.; Hessl, Amy; Hubeny, J. Bradford; Jackson, Stephen T.; Marsicek, Jeremiah; McLachlan, Jason; Mock, Cary J.; Moore, David J. P.; Nichols, Jonathan; Peteet, Dorothy; Schaefer, Kevin; Trouet, Valerie; Umbanhowar, Charles; Williams, John W.; Yu, Zicheng

    2017-10-01

    Many ecosystem processes that influence Earth system feedbacks - vegetation growth, water and nutrient cycling, disturbance regimes - are strongly influenced by multidecadal- to millennial-scale climate variations that cannot be directly observed. Paleoclimate records provide information about these variations, forming the basis of our understanding and modeling of them. Fossil pollen records are abundant in the NE US, but cannot simultaneously provide information about paleoclimate and past vegetation in a modeling context because this leads to circular logic. If pollen data are used to constrain past vegetation changes, then the remaining paleoclimate archives in the northeastern US (NE US) are quite limited. Nonetheless, a growing number of diverse reconstructions have been developed but have not yet been examined together. Here we conduct a systematic review, assessment, and comparison of paleotemperature and paleohydrological proxies from the NE US for the last 3000 years. Regional temperature reconstructions (primarily summer) show a long-term cooling trend (1000 BCE-1700 CE) consistent with hemispheric-scale reconstructions, while hydroclimate data show gradually wetter conditions through the present day. Multiple proxies suggest that a prolonged, widespread drought occurred between 550 and 750 CE. Dry conditions are also evident during the Medieval Climate Anomaly, which was warmer and drier than the Little Ice Age and drier than today. There is some evidence for an acceleration of the longer-term wetting trend in the NE US during the past century; coupled with an abrupt shift from decreasing to increasing temperatures in the past century, these changes could have wide-ranging implications for species distributions, ecosystem dynamics, and extreme weather events. More work is needed to gather paleoclimate data in the NE US to make inter-proxy comparisons and to improve estimates of uncertainty in reconstructions.

  16. Climatic history of the northeastern United States during the past 3000 years

    Directory of Open Access Journals (Sweden)

    J. R. Marlon

    2017-10-01

    Full Text Available Many ecosystem processes that influence Earth system feedbacks – vegetation growth, water and nutrient cycling, disturbance regimes – are strongly influenced by multidecadal- to millennial-scale climate variations that cannot be directly observed. Paleoclimate records provide information about these variations, forming the basis of our understanding and modeling of them. Fossil pollen records are abundant in the NE US, but cannot simultaneously provide information about paleoclimate and past vegetation in a modeling context because this leads to circular logic. If pollen data are used to constrain past vegetation changes, then the remaining paleoclimate archives in the northeastern US (NE US are quite limited. Nonetheless, a growing number of diverse reconstructions have been developed but have not yet been examined together. Here we conduct a systematic review, assessment, and comparison of paleotemperature and paleohydrological proxies from the NE US for the last 3000 years. Regional temperature reconstructions (primarily summer show a long-term cooling trend (1000 BCE–1700 CE consistent with hemispheric-scale reconstructions, while hydroclimate data show gradually wetter conditions through the present day. Multiple proxies suggest that a prolonged, widespread drought occurred between 550 and 750 CE. Dry conditions are also evident during the Medieval Climate Anomaly, which was warmer and drier than the Little Ice Age and drier than today. There is some evidence for an acceleration of the longer-term wetting trend in the NE US during the past century; coupled with an abrupt shift from decreasing to increasing temperatures in the past century, these changes could have wide-ranging implications for species distributions, ecosystem dynamics, and extreme weather events. More work is needed to gather paleoclimate data in the NE US to make inter-proxy comparisons and to improve estimates of uncertainty in reconstructions.

  17. 150 Years of Coulomb Stress History Along the California-Nevada Border, USA.

    Science.gov (United States)

    Carena, S.; Verdecchia, A.

    2014-12-01

    The temporal and spatial correlation among earthquakes in diffuse plate boundary zones is not well understood yet. The region north of the Garlock fault between the Sierra Nevada and Death Valley is part of a diffuse plate boundary zone, which absorbs a significant fraction of the plate motion between Pacific and North America. This area has experienced at least eight Mw ≥ 6 earthquakes in historical times, beginning with the 1872 Mw 7.5 Owens Valley earthquake. Furthermore, since 1978 Long Valley caldera has been undergoing periods of unrest, with earthquake swarms and resurgence. Our goal is to determine whether the 1872 Owens Valley earthquake has influenced the seismicity and volcanic activity in the area. We model the evolution of coseismic, interseismic and postseismic Coulomb stress (ΔCFS) in the region due to both earthquakes and caldera activity in the last 150 years. Our results show that the 1872 Owens Valley earthquake strongly encourages faulting in northern Owens Valley. In addition, there is a correlation among smaller events, in the form of a west-to-east migration of earthquakes from Long Valley caldera toward the White Mountains immediately following the 1978 caldera inflation event. The last event in this sequence, the 1986 Mw 6.3 Chalfant Valley earthquake, controls the location of over 80% of its own aftershocks, which occur in areas of positive ΔCFS and reach Mw 5.7. We also calculate the cumulative ΔCFS on several major active faults in the region. Stresses up to 30 bars and 10 bars respectively have accumulated on the White Mountains (Central section) and Deep Springs faults, comparable to the expected stress drop in an average earthquake. Because no surface ruptures more recent than 1.8 ka have been identified on these faults [dePolo, 1989; Lee et al., 2001], we consider them as likely candidates for the next major earthquake in the region.

  18. 2000 Years of Grazing History and the Making of the Cretan Mountain Landscape, Greece.

    Science.gov (United States)

    Jouffroy-Bapicot, Isabelle; Vannière, Boris; Iglesias, Virginia; Debret, Maxime; Delarras, Jean-François

    2016-01-01

    Understanding the processes that led to the recent evolution of Mediterranean landscapes is a challenging question that can be addressed with paleoecological data. Located in the White Mountains of Crete, Asi Gonia peat bog constitutes an exceptional 2000-years-long sedimentary archive of environmental change. In this study, we document the making of the White Mountains landscape and assess human impact on ecosystem trajectories. The paleoenvironmental reconstruction is based on high-resolution analyses of sediment, pollen, dung fungal spores and charcoal obtained from a 6-m core collected from the bog. Multiproxy analyses and a robust chronological control have shed light on anthropogenic and natural processes that have driven ecological changes, giving rise to the present-day Mediterranean ecosystem. Our results suggest that sediment accumulation began during the transition from the Hellenistic to the Roman period, likely due to watershed management. The evolution of the peat bog as well as vegetation dynamics in the surrounding area were linked to past climate changes but were driven by human activities, among which breeding was of great importance. Charcoal analysis reveals that fire was largely used for the construction and maintenance of sylvo-agropastoral areas. Pollen data allow the identification of three main vegetation assemblages: 1) evergreen oak forest (before ca. 850 AD), 2) heather maquis (ca. 850 to 1870 AD), 3) phrygana/steppe landscape. Rapid changes between phases in vegetation development are associated with tipping-points in ecosystem dynamics resulting from anthropogenic impact. The modern ecosystem did not get established until the 20th century, and it is characterized by biodiversity loss along with a dramatic drying of the peat bog.

  19. A 30-year history of earthquake crisis communication in California and lessons for the future

    Science.gov (United States)

    Jones, L.

    2015-12-01

    The first statement from the US Geological Survey to the California Office of Emergency Services quantifying the probability of a possible future earthquake was made in October 1985 about the probability (approximately 5%) that a M4.7 earthquake located directly beneath the Coronado Bay Bridge in San Diego would be a foreshock to a larger earthquake. In the next 30 years, publication of aftershock advisories have become routine and formal statements about the probability of a larger event have been developed in collaboration with the California Earthquake Prediction Evaluation Council (CEPEC) and sent to CalOES more than a dozen times. Most of these were subsequently released to the public. These communications have spanned a variety of approaches, with and without quantification of the probabilities, and using different ways to express the spatial extent and the magnitude distribution of possible future events. The USGS is re-examining its approach to aftershock probability statements and to operational earthquake forecasting with the goal of creating pre-vetted automated statements that can be released quickly after significant earthquakes. All of the previous formal advisories were written during the earthquake crisis. The time to create and release a statement became shorter with experience from the first public advisory (to the 1988 Lake Elsman earthquake) that was released 18 hours after the triggering event, but was never completed in less than 2 hours. As was done for the Parkfield experiment, the process will be reviewed by CEPEC and NEPEC (National Earthquake Prediction Evaluation Council) so the statements can be sent to the public automatically. This talk will review the advisories, the variations in wording and the public response and compare this with social science research about successful crisis communication, to create recommendations for future advisories

  20. Online Art History: Design, Development, and Review of an Interactive Course.

    Science.gov (United States)

    Schmidt, M.; Blackmon, W. H.; Rehak, D. R.; Bajzek, D.

    Carnegie Mellon Online has been used to deliver several university courses to thousands of students at Carnegie Mellon University (Pittsburgh, Pennsylvania) over the last 2 years. This paper describes the experiences gained from redesigning an introductory art history course using Carnegie Mellon Online to deliver supplemental course content. The…

  1. An 11 000-year-long record of fire and vegetation history at Beaver Lake, Oregon, central Willamette Valley

    Science.gov (United States)

    Walsh, Megan K.; Pearl, Christopher A.; Whitlock, Cathy; Bartlein, Patrick J.; Worona, Marc A.

    2010-01-01

    High-resolution macroscopic charcoal and pollen analysis were used to reconstruct an 11??000-year-long record of fire and vegetation history from Beaver Lake, Oregon, the first complete Holocene paleoecological record from the floor of the Willamette Valley. In the early Holocene (ca 11??000-7500 calendar years before present [cal??yr??BP]), warmer, drier summers than at present led to the establishment of xeric woodland of Quercus, Corylus, and Pseudotsuga near the site. Disturbances (i.e., floods, fires) were common at this time and as a result Alnus rubra grew nearby. High fire frequency occurred in the early Holocene from ca 11??200-9300??cal??yr??BP. Riparian forest and wet prairie developed in the middle Holocene (ca 7500??cal??yr??BP), likely the result of a decrease in the frequency of flooding and a shift to effectively cooler, wetter conditions than before. The vegetation at Beaver Lake remained generally unchanged into the late Holocene (from 4000??cal??yr??BP to present), with the exception of land clearance associated with Euro-American settlement of the valley (ca 160??cal??yr BP). Middle-to-late Holocene increases in fire frequency, coupled with abrupt shifts in fire-episode magnitude and charcoal composition, likely indicate the influence anthropogenic burning near the site. The paleoecological record from Beaver Lake, and in particular the general increase in fire frequency over the last 8500??years, differs significantly from other low-elevation sites in the Pacific Northwest, which suggests that local controls (e.g., shifts in vegetation structure, intensification of human land-use), rather than regional climatic controls, more strongly influenced its environmental history. ?? 2010 Elsevier Ltd.

  2. 1972-1997, Twenty-five years of energy and environmental history : lessons learned.

    Energy Technology Data Exchange (ETDEWEB)

    Drucker, H.

    1997-12-17

    Given the events of the past 25 years concerning energy and environmental issues and our reaction to them, what lessons can we learn? First, the individual American consumer wants and expects energy to be a stable commodity with low prices and easy availability. As evidenced by the heated debate over increasing the federal gasoline tax by $.05 per gallon (which would still leave Americans paying only one-third of what Europeans pay for gasoline), increases in energy prices elicit very strong public and political opposition. As further evidence, it has been argued that the general public support of the Gulf War was due, in part, to a recognition of the need to maintain a stable source of cheap oil from the region. The American public wants to maintain the benefits of cheap and abundant energy and expects its political leaders to make it happen. A second lesson is that if constraints on the energy supply do occur (e.g., the OPEC-imposed oil embargo) ardor environmental impacts from energy use do appear to be significant (e.g., SO{sub 2} and CO{sub 2} emissions), the preference is for a technology fix rather than a behavioral change. This is evidenced by our reliance on moving low-sulfur coal more than 1,000 miles from Wyoming to burn in Illinois power plants rather than reducing the demand for electricity with energy-efficient measures in residential, commercial, and industrial activities. National research programs to produce an automobile that gets 80+ miles per gallon take higher priority over working to get people to use mass transit to reduce their driving mileage. Americans expect that advanced technology can be relied upon to come up with solutions to energy and environmental problems without having to change their lifestyles. The experience with natural gas, in which a regulatory change (deregulation) was combined with technology developments (horizontal drilling and improved gas turbines for electricity generation) to increase available supply and hold

  3. Genome-wide genotype and sequence-based reconstruction of the 140,000 year history of modern human ancestry.

    Science.gov (United States)

    Shriner, Daniel; Tekola-Ayele, Fasil; Adeyemo, Adebowale; Rotimi, Charles N

    2014-08-13

    We investigated ancestry of 3,528 modern humans from 163 samples. We identified 19 ancestral components, with 94.4% of individuals showing mixed ancestry. After using whole genome sequences to correct for ascertainment biases in genome-wide genotype data, we dated the oldest divergence event to 140,000 years ago. We detected an Out-of-Africa migration 100,000-87,000 years ago, leading to peoples of the Americas, east and north Asia, and Oceania, followed by another migration 61,000-44,000 years ago, leading to peoples of the Caucasus, Europe, the Middle East, and south Asia. We dated eight divergence events to 33,000-20,000 years ago, coincident with the Last Glacial Maximum. We refined understanding of the ancestry of several ethno-linguistic groups, including African Americans, Ethiopians, the Kalash, Latin Americans, Mozabites, Pygmies, and Uygurs, as well as the CEU sample. Ubiquity of mixed ancestry emphasizes the importance of accounting for ancestry in history, forensics, and health.

  4. A 16-year-old girl with anti-NMDA-receptor encephalitis and family history of psychotic disorders.

    Science.gov (United States)

    Cleland, Neil; Lieblich, Samuel; Schalling, Martin; Rahm, Christoffer

    2015-12-01

    Autoimmune NMDA-R encephalitis (ANRE) shares clinical features with schizophrenia. Recent research also indicates that both disorders are associated with dysfunction of the N-Methyl-D-Aspartate glutamate receptors (NMDA-R) subunit 1. We present the case of Ms A, 16 years old. Ms A presented with acute personality change, bizarre behaviour, delusional ideas and atypical seizures. She had a family history of psychotic disorders, and autistic traits diagnosed in childhood. She was initially diagnosed with a psychotic disorder. Delayed testing of CSF indicated ANRE. As the patient was a Jehovah's witness the treating team was unable to use gammaglobulin therapy; they instead relied on combined plasmapheresis and rituximab. To exclude the possibility that the affected members of this family shared a gene coding for an abnormal configuration of the NMDA receptor subunit 1 we sequenced the region of the GRIN1 gene in DNA extracted from blood in both Ms A and her grandmother. Ms A's condition improved dramatically, though her long-term memory is still demonstrably impaired. No genetic abnormality was detected. This case emphasizes how important it is, for a first episode psychosis, to exclude ANRE and other autoimmune synaptic encephalitides, even in the face of significant family history, and if seronegative, the importance of testing for CSF autoantibodies.

  5. HISTORY OF FORESTS IN THE MIDDLE IRTYSH AREA DURING THE IRON AGE (2500 YEARS AGO – PRESENT

    Directory of Open Access Journals (Sweden)

    М. А. Kharitonenkov

    2017-12-01

    Full Text Available Based on a complex chronological analysis of palynological, archaeological and historical data, the reconstruction of the history of forest ecosystems in one of the major historical and geographical regions of Western Siberia, the Middle Irtysh region, is presented. The main stages of transformation in the region’s forests have been traced, starting from the early Iron Age (2500 years agi. The role of various aspects in the traditional economy, as well as the major migration processes in the formation of modern natural zonality of the region, is analyzed. The data of three new palynological sequences laid on the territory of the present subtaiga and forest steppe in the Middle Irtysh region and significantly reduced the unevenness of the palynological study of the West Siberian Plain is published for the first time.

  6. Voices of young people with a history of specific language impairment (SLI) in the first year of post-16 education.

    Science.gov (United States)

    Palikara, Olympia; Lindsay, Geoff; Dockrell, Julie E

    2009-01-01

    Giving young people more and better opportunities to have their voices heard is a key feature of current educational policy and research internationally and in the UK. To examine the views of young people with a history of specific language impairment (SLI) as they entered post-16 education. A total of 54 students identified as having SLI at 8 years of age were followed up through primary and secondary school to post-16 destinations. Most had been educated in mainstream schools. The young people were interviewed individually in relation to their perceptions of their special educational needs, their views on service provision, the role of family and friends as support systems, and their aspirations and barriers to future education at the early stages of post-16 education, training and work. The young people were able to offer accurate accounts of their history of special educational needs and to explore issues related to their development. Most young people were aware of the specific difficulties they experienced and had positive views about the support offered to them during their schooling. All the young people had at least one person in their family or friendship circle to whom they could talk about their joys and concerns, and friendships were an important and positive element in their lives. Additionally, most had a positive view of their post-16 courses, with comparable numbers hoping to undertake further study or training, or to go into work. They also had optimistic hopes for their futures five years ahead. The current study has demonstrated that young people with a history of SLI have an awareness of their difficulties and of the impact that these needs have on different aspects of their lives. They were also able to provide valuable views of service provision, both in terms of evaluating the support they received and suggesting ways of improving it. Ascertaining the views of younger children with SLI and including them in decision-making about their

  7. TAU: a design for a thousand astronomical unit voyage

    International Nuclear Information System (INIS)

    Eubanks, D.; Alvis, J.; Bechler, E.; Lyon, W. III; McFarlane, D.; Palmrose, D.; Schmitz, P.

    1987-01-01

    The Jet Propulsion Lab. (JPL) has proposed a deep-space probe to travel to a distance of one thousand astronomical units -25 times further from the Sun than Pluto. In order to achieve this goal within the lifetime of the investigators, the mission time is set at a maximum of 50 yr. The JPL proposal postulates a design in which the probe is under powered thrust for the first 10 yr of the mission and coasts for the next 40 yr. A continuous high specific impulse, Isp (the ratio of thrust to propellant mass flow rate), low thrust propulsion system (either magnetoplasmadynamic (MPD) or ion thrusters) is required in order to achieve this goal. This in turn necessitates electrical power in the megawatt range. The only power source that is practical for this situation is a nuclear reactor. It was a this point that the Nuclear Engineering Dept. at Texas A and M Univ. began its ongoing work, looking into several areas of the proposal in which a more detailed description was needed. These areas of interest were power, propulsion, heavy lift launch capabilities, and trajectory analysis. In addition to all of the boundaries previously outlined, the technology level is assumed to be that of 1995, 8 yr from now

  8. Slow Processing Speed Predicts Falls in Older Adults With a Falls History: 1-Year Prospective Cohort Study.

    Science.gov (United States)

    Davis, Jennifer C; Best, John R; Khan, Karim M; Dian, Larry; Lord, Stephen; Delbaere, Kim; Hsu, Chun Liang; Cheung, Winnie; Chan, Wency; Liu-Ambrose, Teresa

    2017-05-01

    A previous fall is a strong predictor of future falls. Recent epidemiologic data suggest that deficits in processing speed predict future injurious falls. Our primary objective was to determine a parsimonious predictive model of future falls among older adults who experienced ≥1 fall in the past 12 months based on the following categories: counts of (1) total, (2) indoor, (3) outdoor or (4) non-injurious falls; (5) one mild or severe injury fall (yes vs no); (6) an injurious instead of a non-injurious fall; and (7) an outdoor instead of an indoor fall. 12-month prospective cohort study. Vancouver Falls Prevention Clinic, Canada (www.fallsclinic.ca). Two-hundred and eighty-eight community-dwelling older adults aged ≥70 years with a history of ≥1 fall resulting in medical attention in the previous 12 months. We employed principal component analysis to reduce the baseline predictor variables to a smaller set of five factors (i.e., processing speed, working memory, emotional functioning, physical functioning and body composition/fall risk profile). Second, we used the extracted five factors as predictors in regression models predicting the incidence of falls over a 12-month prospective observation period. We conducted regression analyses for the seven falls-related categories (defined above). Among older adults with a falls history, processing speed was the most consistent predictor of future falls; poorer processing speed predicted a greater number of total, indoor, outdoor, and non-injurious falls, and a greater likelihood of experiencing at least one mild or severe injurious fall (all P values factor, a trainable factor, was independently associated with the most costly type of falls-injurious falls. © 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society.

  9. Emotional eating, marital status and history of physical abuse predict 2-year weight loss in weight loss surgery patients.

    Science.gov (United States)

    Wedin, Sharlene; Madan, Alok; Correll, Jennifer; Crowley, Nina; Malcolm, Robert; Karl Byrne, T; Borckardt, Jeffrey J

    2014-12-01

    Weight loss surgery (WLS) is an effective weight loss treatment for individuals with severe obesity. Psychosocial factors can affect short-term WLS outcomes. This study sought to identify psychosocial predictors of medium-term outcomes. In this prospective study, 250 consecutive WLS candidates were evaluated between January 1, 2010 and December 31, 2010. Each completed baseline medical, surgical, and psychological evaluations as part of standard of care. Two hundred and four patients had surgery (81.6%). Successful surgical outcome was defined as ≥50% excess weight loss two years post-surgery. Comparison of study sample (n=80) and those lost to follow-up (n=124) revealed negligible differences across baseline characteristics. At follow-up, 60% (n=48) of the sample was classified as a success with an average of 72.58% (std dev=13.01%) excess weight lost. The remaining 40% (n=32) was classified as a failure with an average of 33.98% (std dev=13.19%) excess weight lost. Logistic regression revealed that pre-surgical marital status, emotional eating, and history of physical abuse were independently associated with outcome variables, pemotionally driven disordered eating patterns are associated with 7.4 times increased odds of medium-term WLS success. A history of physical abuse is associated with an 84% decreased odds of successful medium-term outcomes. Further research that studies both the quality and impact of spousal support on weight loss as well as longer-term effects of emotional eating on outcomes is needed. Addressing longer-standing consequence of abuse may improve WLS outcomes. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Mille modis morimur: We die in a thousand ways.

    Science.gov (United States)

    Banfalvi, Gaspar

    2017-02-01

    Dying cells subjected to apoptotic programs are engulfed by neighboring cells or by professional phagocytes, without inflammation or immunological reactions in the tissue where apoptosis takes place. Apoptotic cells release danger-associated project signals to their neighbours, through different molecular patterns, stimulate antigen production and immune responses. Microenvironmental effects with several functional consequences indicate that cell death is a complex process and may take place in several ways. This idea is expressed by the title of the Special Issue and by the title of the guest editorial "Mille modis morimur" meaning that not only multicellular organisms, but also single cells may die in a thousand ways. This idea is demonstrated by the papers serving as examples for cell death. Apoptosis was induced by clary sage oil in Candida cells. Heavy metal (Gd) induced cell motility and apoptosis was found in mammalian cells. RNA oxidation enhanced the reversion frequency of apoptosis in yeast mutants. The frequency of apoptotic micronucleus formation increased in a concentration-dependent manner by methotrexate. The antioxidant coenzyme Q10 protected renal proximal tubule cells against nicotine-induced apoptosis. The synergy of 2-deoxy-D-glucose combined with berberine induced lysosome/autophagy. The mitochondrial apoptotic pathway could be regulated by glucocorticoid receptor in collaboration with Bcl-2 family proteins in developing T cells. Cylindrospermopsin induced biochemical changes led to apoptosis in plants. Mechanisms of stress seriously impacted the risk of apoptosis. Transcriptional control of apoptotic cell clearance was achieved by macrophage nuclear receptors. Finally, the clinical aspects of apoptosis-induced lymphopenia were reviewed in sepsis and other severe injuries. These examples not only support the view of many ways of cell death, but predict further potential ways to induce or reduce the risk of cell death.

  11. History of head trauma in a 6-year-old boy: maybe more than meets the eye (and head).

    Science.gov (United States)

    Scherl, Leslie; Douglass, Laurie; Augustyn, Marilyn

    2013-01-01

    the details from the story. Currently, he does not have good memory recall. Before the trauma, he did not attend a preschool program but stayed home with his mother full time. Eddie's first formal schooling has been kindergarten this year. When they moved, the neurosurgeon recommended he start school at the end of September given his head trauma in August. He had a recent computed tomography completed 3 months ago showing the epidural hematoma had completely resolved and the study was otherwise normal. His mother reports he had an evaluation the spring before the accident for a kindergarten screening test and was reported as "excellent." Eddie's birth and medical history are otherwise unremarkable except for some seasonal allergies. He has not had a loss in language skill, although his mother reports he did not speak during his hospitalization. He would just stare and nod his head if someone would ask him a question. No family history of any learning or behavioral difficulties on either side of the family. Eddie has 2 older brothers, 10 and 7 years of age, with no learning issues.What would you do next?

  12. One-Year Follow-Up of Suicidal Adolescents: Parental History of Mental Health Problems and Time to Post-Hospitalization Attempt

    Science.gov (United States)

    King, Cheryl A.; Kerr, David C. R.; Passarelli, Michael N.; Foster, Cynthia Ewell; Merchant, Christopher R.

    2010-01-01

    This longitudinal study of recently hospitalized suicidal youth examined parental mental health history in addition to several indices of adolescent functioning as risk factors for time-to-suicide attempt over a 1-year period. Participants were 352 adolescents (253 girls, 99 boys; ages 13-17 years) who participated in self-report and interview…

  13. A history of mathematics

    CERN Document Server

    Boyer, Carl B

    1989-01-01

    "Boyer and Merzbach distill thousands of years of mathematics into this fascinating chronicle. From the Greeks to Godel, the mathematics is brilliant; the cast of characters is distinguished; the ebb and flow of ideas is everywhere evident. And, while tracing the development of European mathematics, the authors do not overlook the contributions of Chinese, Indian, and Arabic civilizations. Without doubt, this is--and will long remain--a classic one-volume history of mathematics and mathematicians who create it." --William Dunham Author, Journey Through Genius, The Great Theorems of Mathematics "When we read a book like A History of Mathematics, we get the picture of a mounting structure, ever taller and broader and more beautiful and magnificent--and with a foundation, moreover, that is as untainted and as functional now as it was when Thales worked out the first geometrical theorems nearly 26 centuries ago." --From the Foreword by Isaac Asimov "One of the most useful and comprehensive general introductions t...

  14. Hypothyroidism in a five-year-old boy with rhabdomyolysis and recent history of cardiac tamponade: a case report

    Directory of Open Access Journals (Sweden)

    Lorenzana Claudia

    2011-10-01

    Full Text Available Abstract Introduction Cardiac tamponade is a rare manifestation of hypothyroidism, and a less rare cause of pericardial effusion. The accumulation of the pericardial fluid is gradual, and often does not compromise cardiac hemodynamic function. There is a relationship between the severity and chronicity of the disease with the presence of pericardial effusion. There are few cases describing associated pericardial tamponade published in the literature. When a tamponade occurs, a concomitant provocative factor such as a viral pericarditis may be related. Our patient's case appears to be the youngest patient described so far. Case presentation We report the case of a previously healthy five-year-old Hispanic (non-indigenous boy who developed rhabdomyolysis with a history of a recent pericardial effusion and tamponade two months before that required the placement of a percutaneous pericardial drainage. Pericardial effusion was considered to be viral. Later on readmission, clinical primary hypothyroidism was diagnosed and thought to be associated with the previous cardiac tamponade. He developed rhabdomyolysis, which was considered to be autoimmune and was treated with steroids. The level of creatine phosphate kinase and creatine kinase MB fraction returned to within the reference rangeone week after our patient was started on steroids and three weeks after he was started on thyroid hormones. Conclusions Physicians should consider hypothyroidism as a differential diagnosis in patients with pericardial effusion. Pericardial effusion may progress and cause a cardiac tamponade with hemodynamic instability. The fact that our patient did not have any manifestations of hypothyroidism might have delayed diagnosis.

  15. Human radiation studies: Remembering the early years. Oral history of Biochemist Waldo E. Cohn, Ph.D

    International Nuclear Information System (INIS)

    1995-01-01

    In September 1994, the Department of Energy began an oral history project as part of the Openess initiative on the documentation of the human radiation experiments. This paper presents the oral history of Waldo E Cohn, Ph.D., a Biochemist who worked for the Oak Ridge National Laboratory and the Manhattan Project

  16. 52 years of Kahl pilot nuclear power station. A special chapter in German technology history come to an end

    International Nuclear Information System (INIS)

    Hackel, Walter

    2011-01-01

    Since October 2010, the site of the former Kahl Experimental Nuclear Power Station (VAK) has been returned to the desired green-field condition. A special chapter in the German history of the use of nuclear power, which has played a major role in the technical and economic development of this energy resource, has come to an end after 52 years. When nuclear power pioneer Heinrich Mandel ordered VAK from AEG in 1958, the mood associated with using this source of energy was different from what it is now. Politicians of all parties were euphoric about the use of nuclear power, while power plant operators were more reluctant. Finally, also RWE was convinced and planned the construction of VAK as a joint venture with the Bayernwerk AG (now E.ON) utility in Grosswelzheim, Bavaria. The objective was clear: 'The order was placed so that the atomic power plant to be built could be used to accumulate experience in planning, operation, in capital cost and operating cost.' After a construction period of only 29 months, VAK was commissioned on November 13, 1960 as the first German nuclear power plant. The US-designed boiling water reactor had been designed for a power of 16,000 kilowatt. After synchronization with the power grid, the first electricity produced from nuclear power in Germany was fed into the interconnected grid system on June 17, 1961. In its 25 years of operation, VAK proved to be a valuable experimental facility. The plant was decommissioned on November 25, 1985 as planned. In order to maintain its experimental character also beyond the operating phase, the operators had agreed from the beginning to demolish VAK completely to green-field conditions immediately after the end of operations. This became official on May 17, 2010, when the plant was released from the scope of the Atomic Energy Act and was granted a permit for demolition under conventional building law. (orig.)

  17. ICDP project DeepCHALLA: reconstructing East African climate change and environmental history over the past 250,000 years

    Science.gov (United States)

    Verschuren, Dirk; Van Daele, Maarten; Wolff, Christian; Waldmann, Nicolas; Meyer, Inka; Ombori, Titus; Peterse, Francien; O'Grady, Ryan; Schnurrenberger, Doug; Olago, Daniel

    2017-04-01

    Sediments on the bottom of Lake Challa, a 92-meter deep crater lake on the border of Kenya and Tanzania near Mt. Kilimanjaro, contain a uniquely long and continuous record of past climate and environmental change. The near-equatorial location and exceptional quality of this natural archive provide great opportunities to study tropical climate variability at both short (inter-annual to decadal) and long (glacial-interglacial) time scales; and the influence of this climate variability on the region's freshwater resources, the functioning of terrestrial ecosystems, and the history of the East African landscape in which modern humans (our species, Homo sapiens) evolved and have lived ever since. Supported in part by the International Continental Scientific Drilling Programme (ICDP), the DeepCHALLA project has now recovered the sediment record of Lake Challa down to 214.8 meter below the lake floor, with almost certain 100% cover of the uppermost 121.3 meter (ca.150,000 year BP to present) and estimated 85% cover over the lower part of the sequence, down to the lowermost distinct reflector in the available seismic stratigraphy. This reflector represents a 2 meter thick layer of volcanic sand and silt deposited ca.250,000 years ago, and overlies still older silty lacustrine clays deposited during early lake development. Down-hole logging produced continuous profiles of in-situ sediment composition that confer an absolute depth scale to both the recovered cores and their three-dimensional representation in seismic stratigraphy. As readily observed through the transparent core liners, Lake Challa sediments are finely laminated throughout most of the recovered sequence. Combined with the great time span, the exquisite temporal resolution of these sediments promises to greatly increase our understanding of tropical climate and ecosystem dynamics, and create a long-awaited equatorial counterpart to the high-latitude climate records extracted from the ice sheets of Greenland

  18. The History of Development of Land Registration and Ownership Rights in Kosovo, Legal Challenges During the Years 1912-2014

    Directory of Open Access Journals (Sweden)

    LL.M. Blerta Rudi

    2014-06-01

    Full Text Available Knowing that the registration of ownership rights is very important institute for legal and economic system of Kosovo, for its constitutive effect in gaining of ownership rights, protection of property rights of the owner and which enables effective management of the land, in order to understand its development, is necessary to turn back to history. Regarding to this, Kosovo is not known for an early origin and consolidated system of land registration until Twentieth Century; even afterwards, its development was influenced by many socio-economic and political factors. The review of the historical development of land records deserves a detailed study in Kosovo due to its complexity through the years, so in order to understand more accurately the footsteps of regimes, it is necessary to examine periods until 1912, 1912-1999 and 1999 till now days, because the elaboration of normative acts that arranged registration over the years, enable the readers to create a clear overview related to advances and characteristics of each stage of its development,therefore the differences and similiarities can be noticed clearly through descriptive and comparison method. Especially postwar period is characterized by major advances and essential changes as: Approval of Constitution and abrogation of old system. These changes contained fairly challenges, but important is that the situation normalized and is moving towards positive trends of legislative development. Actually, in Kosovo, property rights are receiving deserved attention, but it is somewhat worrying the emphasizing lack of the review of the registration, reason that encouraged me to elaborate this topic in order to gain more knowledge about the institute of registration system and complexities that accompanies it.

  19. The Ability of a Single BMD and Fracture History Assessment to Predict Fracture Over 25 Years in Postmenopausal Women: The Study of Osteoporotic Fractures.

    Science.gov (United States)

    Black, Dennis M; Cauley, Jane A; Wagman, Rachel; Ensrud, Kristine; Fink, Howard A; Hillier, Teresa A; Lui, Li-Yung; Cummings, Steven R; Schousboe, John T; Napoli, Nicola

    2018-03-01

    The ability of bone mineral density (BMD) and other risk factors to predict fracture risk is well-established for as long as 5 to 10 years. However, their value to predict risk over a longer term has not been directly studied. We investigated whether a single assessment of femoral neck BMD and fracture history can predict fracture risk over 20 to 25 years. We used data from the Study of Osteoporotic Fractures (SOF) that assessed BMD and risk factors in 7959 women age ≥67 (mean = 73.4) in 1988-1990. Follow-up for fractures continued for 25 years for hip fracture, and for 20 years for any nonvertebral fracture. Using age-adjusted proportional hazards models, we analyzed the relationships between a single baseline assessment of femoral neck BMD, fracture history and age, and 20-25-year fracture incidence. The 25-year cumulative incidence of hip fracture was 17.9%; 20-year incidence of any nonvertebral fracture was 46.2%. The 25-year hip fracture incidence was highest in those ≥80 years old (22.6%) compared to 13.9% in women aged hip fracture risk to 25 years: 29.6% risk in the lowest BMD quartile versus 7.6% with the highest relative hazard (RH) = 4.9 (95% CI, 4.1 to 6.0). Femoral neck BMD predicted hip fracture with little degradation over time from RH/SD = 2.6 (2.2 to 3.0) for 0 to 5 years to RH/SD = 1.8 (1.4 to 2.4) for 20 to 25 years. Lifetime hip fracture risk was similar (∼30%) regardless of age from 67 to >80 years. History of hip fracture predicted hip fractures only slightly better than history of nonvertebral fracture (RH = 1.6 [95% CI, 1.1 to 2.2] versus RH = 1.4 [95% CI, 1.2 to 1.5], respectively). Fracture history remained strongly predictive up to 25 years. We conclude that a single BMD and fracture history assessment can predict fracture risk over 20 to 25 years. Long-term risk of hip fracture remains extremely high in the oldest age groups, supporting risk assessment and consideration of treatment even in the oldest

  20. Balkan Wars in Social Studies and History Course Books Instructed at Primary and Secondary Education between 1997 and 2012 Years

    OpenAIRE

    KÖSE, Meliha

    2014-01-01

    1912-1913 Balkan Wars ended with important social, economical, cultural and political results for both Southeast Europe and Ottoman Empire. It is a significant turning point for the history of Turkey as well as World History. Balkan Wars had important effects on from dawn of Modern Turkey to starting of national struggle war and coming fore of national identity wars. That’s why It is a point to be emphasized how Balkan Wars are taught in both Turkish and Balkan history books. Primary educatio...

  1. History of Overweight/Obesity as Predictor of Care Received at 1-year Follow-Up in Adolescents With Anorexia Nervosa or Atypical Anorexia Nervosa.

    Science.gov (United States)

    Kennedy, Grace A; Forman, Sara F; Woods, Elizabeth R; Hergenroeder, Albert C; Mammel, Kathleen A; Fisher, Martin M; Ornstein, Rollyn M; Callahan, S Todd; Golden, Neville H; Kapphahn, Cynthia J; Garber, Andrea K; Rome, Ellen S; Richmond, Tracy K

    2017-06-01

    Previous research has indicated that patients with anorexia nervosa (AN) or atypical AN with premorbid history of overweight/obesity have greater weight loss and longer illness duration than patients with no such history. However, little is known about the association of premorbid overweight/obesity and receiving inpatient medical care during treatment for an eating disorder. Using logistic regression, we sought to determine if history of overweight/obesity was associated with receiving inpatient medical care in a sample of 522 patients (mean age 15.5 years, 88% female) with AN/atypical AN. Binary results demonstrated greater percent weight loss (27.4% vs. 16.2%) and higher percent median body mass index (%mBMI, 99.8% vs. 85.2%) at presentation in those with a history of overweight/obesity (p Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  2. History of Antibiotics Research.

    Science.gov (United States)

    Mohr, Kathrin I

    2016-01-01

    For thousands of years people were delivered helplessly to various kinds of infections, which often reached epidemic proportions and have cost the lives of millions of people. This is precisely the age since mankind has been thinking of infectious diseases and the question of their causes. However, due to a lack of knowledge, the search for strategies to fight, heal, and prevent the spread of communicable diseases was unsuccessful for a long time. It was not until the discovery of the healing effects of (antibiotic producing) molds, the first microscopic observations of microorganisms in the seventeenth century, the refutation of the abiogenesis theory, and the dissolution of the question "What is the nature of infectious diseases?" that the first milestones within the history of antibiotics research were set. Then new discoveries accelerated rapidly: Bacteria could be isolated and cultured and were identified as possible agents of diseases as well as producers of bioactive metabolites. At the same time the first synthetic antibiotics were developed and shortly thereafter, thousands of synthetic substances as well as millions of soil borne bacteria and fungi were screened for bioactivity within numerous microbial laboratories of pharmaceutical companies. New antibiotic classes with different targets were discovered as on assembly line production. With the beginning of the twentieth century, many of the diseases which reached epidemic proportions at the time-e.g., cholera, syphilis, plague, tuberculosis, or typhoid fever, just to name a few, could be combatted with new discovered antibiotics. It should be considered that hundred years ago the market launch of new antibiotics was significantly faster and less complicated than today (where it takes 10-12 years in average between the discovery of a new antibiotic until the launch). After the first euphoria it was quickly realized that bacteria are able to develop, acquire, and spread numerous resistance mechanisms

  3. One thousand cases of severe occupational contact dermatitis

    DEFF Research Database (Denmark)

    Schwensen, Jakob Ferløv; Friis, Ulrik Fischer; Menné, Torkil

    2013-01-01

    dermatitis. Females at high riskwere cooks, butchers, beauticians, bakers, and hairdressers, ranging from 23.3 to 96.8 cases per 10 000 workers per year. Males at high risk were painters, cooks, mechanics, locksmiths, and bakers, ranging from 16.5 to 32.3 cases per 10000 workers per year. Conclusions...

  4. Natural History of Intrameniscal Signal Intensity on Knee MR Images: Six Years of Data from the Osteoarthritis Initiative

    Science.gov (United States)

    Roemer, Frank W.; Guermazi, Ali; Turkiewicz, Aleksandra; Englund, Martin

    2016-01-01

    Purpose To assess the natural history of intrameniscal signal intensity on magnetic resonance (MR) images of the medial compartment. Materials and Methods Both knees of 269 participants (55% women, aged 45–55 years) in the Osteoarthritis Initiative without radiographic knee osteoarthritis (OA) and without medial meniscal tear at baseline were studied. One radiologist assessed 3-T MR images from baseline and 24-, 48-, and 72-month follow-up for intrameniscal signal intensity and tears. A complementary log-log model with random effect was used to evaluate the risk of medial meniscal tear, adjusting for age, sex, body mass index, and knee side. Results At baseline, linear intrameniscal signal intensity in the medial compartment was present in 140 knees (26%). Once present, regression only in a single knee was observed. In 31 knees (19%) with linear intrameniscal signal intensity at any of the first three time points, the signal intensity progressed to a tear in the same segment, and in a single knee, the tear occurred in an adjacent segment. The corresponding number of tears without prior finding of intrameniscal signal intensities was 11 (3%). In the adjusted model, the hazard ratio for developing medial meniscal tear was 18.2 (95% confidence interval: 8.3, 39.8) if linear intrameniscal signal intensity was present, compared when there was no linear signal intensity. There was only one of 43 knees with injury reported in conjunction with the incident tear. Conclusion In middle-aged persons without OA, linear intrameniscal signal intensity on MR images is highly unlikely to resolve and should be considered a risk factor for medial degenerative meniscal tear. © RSNA, 2015 Online supplemental material is available for this article. PMID:26172533

  5. The ventricular system of the brain: a comprehensive review of its history, anatomy, histology, embryology, and surgical considerations.

    Science.gov (United States)

    Mortazavi, M M; Adeeb, N; Griessenauer, C J; Sheikh, H; Shahidi, S; Tubbs, R I; Tubbs, R S

    2014-01-01

    The cerebral ventricles have been recognized since ancient medical history. Their true function started to be realized more than a thousand years later. Their anatomy and function are extremely important in the neurosurgical panorama. The literature was searched for articles and textbooks of different topics related to the history, anatomy, physiology, histology, embryology and surgical considerations of the brain ventricles. Herein, we summarize the literature about the cerebral ventricular system.

  6. Tracing the 4000 year history of organic thin films: From monolayers on liquids to multilayers on solidsa)

    Science.gov (United States)

    Greene, J. E.

    2015-03-01

    The recorded history of organic monolayer and multilayer thin films spans approximately 4000 years. Fatty-acid-based monolayers were deposited on water by the ancients for applications ranging from fortune telling in King Hammurabi's time (˜1800 BC, Mesopotamia) to stilling choppy waters for sailors and divers as reported by the Roman philosopher Pliny the Elder in ˜78 AD, and then much later (1774) by the peripatetic American statesman and natural philosopher Benjamin Franklin, to Japanese "floating-ink" art (suminagashi) developed ˜1000 years ago. The modern science of organic monolayers began in the late-1800s/early-1900s with experiments by Lord Rayleigh and the important development by Agnes Pockels, followed two decades later by Irving Langmuir, of the tools and technology to measure the surface tension of liquids, the surface pressure of organic monolayers deposited on water, interfacial properties, molecular conformation of the organic layers, and phase transitions which occur upon compressing the monolayers. In 1935, Katherine Blodgett published a landmark paper showing that multilayers can be synthesized on solid substrates, with controlled thickness and composition, using an apparatus now known as the Langmuir-Blodgett (L-B) trough. A disadvantage of LB films for some applications is that they form weak physisorbed bonds to the substrate. In 1946, Bigelow, Pickett, and Zisman demonstrated, in another seminal paper, the growth of organic self-assembled monolayers (SAMs) via spontaneous adsorption from solution, rather than from the water/air interface, onto SiO2 and metal substrates. SAMs are close-packed two-dimensional organic crystals which exhibit strong covalent bonding to the substrate. The first multicomponent adsorbed monolayers and multilayer SAMs were produced in the early 1980s. Langmuir monolayers, L-B multilayers, and self-assembled mono- and multilayers have found an extraordinarily broad range of applications including controlled wetting

  7. Tracing the 4000 year history of organic thin films: From monolayers on liquids to multilayers on solids

    Energy Technology Data Exchange (ETDEWEB)

    Greene, J. E. [University of Illinois, Urbana, Illinois 61801 (United States); Linköping University, 581 83 Linköping (Sweden); National Taiwan University of Science and Technology, Taipei 10607, Taiwan (China)

    2015-03-15

    The recorded history of organic monolayer and multilayer thin films spans approximately 4000 years. Fatty-acid-based monolayers were deposited on water by the ancients for applications ranging from fortune telling in King Hammurabi's time (∼1800 BC, Mesopotamia) to stilling choppy waters for sailors and divers as reported by the Roman philosopher Pliny the Elder in ∼78 AD, and then much later (1774) by the peripatetic American statesman and natural philosopher Benjamin Franklin, to Japanese “floating-ink” art (suminagashi) developed ∼1000 years ago. The modern science of organic monolayers began in the late-1800s/early-1900s with experiments by Lord Rayleigh and the important development by Agnes Pockels, followed two decades later by Irving Langmuir, of the tools and technology to measure the surface tension of liquids, the surface pressure of organic monolayers deposited on water, interfacial properties, molecular conformation of the organic layers, and phase transitions which occur upon compressing the monolayers. In 1935, Katherine Blodgett published a landmark paper showing that multilayers can be synthesized on solid substrates, with controlled thickness and composition, using an apparatus now known as the Langmuir-Blodgett (L-B) trough. A disadvantage of LB films for some applications is that they form weak physisorbed bonds to the substrate. In 1946, Bigelow, Pickett, and Zisman demonstrated, in another seminal paper, the growth of organic self-assembled monolayers (SAMs) via spontaneous adsorption from solution, rather than from the water/air interface, onto SiO{sub 2} and metal substrates. SAMs are close-packed two-dimensional organic crystals which exhibit strong covalent bonding to the substrate. The first multicomponent adsorbed monolayers and multilayer SAMs were produced in the early 1980s. Langmuir monolayers, L-B multilayers, and self-assembled mono- and multilayers have found an extraordinarily broad range of applications including

  8. A decision-tree-based method for reconstructing disturbance history in the Russia boreal forests over 30 years

    Science.gov (United States)

    Chen, D.; Loboda, T. V.

    2012-12-01

    The boreal forest is one of the largest biomes on Earth and carries crucial significance in numerous aspects. Located in the high latitude region of the Northern Hemisphere, it is predicted that the boreal forest is subject to the highest level of influence under the changing climate, which may impose profound impacts on the global carbon and energy budget. Of the entire boreal biome, approximately two thirds consists of the Russian boreal forest, which is also the largest forested zone in the world. Fire and logging have been the predominant disturbance types in the Russian boreal forest, which accelerate the speed of carbon release into the atmosphere. To better understand these processes, records of past disturbance are in great need. However, there has been no comprehensive and unbiased multi-decadal record of forest disturbance in this region. This paper illustrates a method for reconstructing disturbance history in the Russia boreal forests over 30 years. This method takes advantage of data from both Landsat, which has a long data record but limited spatial coverage, and the Moderate Resolution Spectroradiometer (MODIS), which has wall-to-wall spatial coverage but limited period of observations. We developed a standardized and semi-automated approach to extract training and validation data samples from Landsat imagery. Landsat data, dating back to 1984, were used to generate maps of forest disturbance using temporal shifts in Disturbance Index through the multi-temporal stack of imagery in selected locations. The disturbed forests are attributed to logging or burning causes by means of visual examination. The Landsat-based disturbance maps are then used as reference data to train a decision tree classifier on 2003 MODIS data. This classifier utilizes multiple direct MODIS products including the BRDF-adjusted surface reflectance, a suite of vegetation indices, and land surface temperature. The algorithm also capitalizes on seasonal variability in class

  9. Tracing the 5000-year recorded history of inorganic thin films from ˜3000 BC to the early 1900s AD

    Science.gov (United States)

    Greene, J. E.

    2014-12-01

    Gold is very likely the first metal discovered by man, more than 11 000 years ago. However, unlike copper (˜9000 BC), bronze (˜3500 BC), and wrought iron (˜2500-3000 BC), gold is too soft for fabrication of tools and weapons. Instead, it was used for decoration, religious artifacts, and commerce. The earliest documented inorganic thin films were gold layers, some less than 3000 Å thick, produced chemi-mechanically by Egyptians approximately 5000 years ago. Examples, gilded on statues and artifacts (requiring interfacial adhesion layers), were found in early stone pyramids dating to ˜2650 BC in Saqqara, Egypt. Spectacular samples of embossed Au sheets date to at least 2600 BC. The Moche Indians of northern Peru developed electroless gold plating (an auto-catalytic reaction) in ˜100 BC and applied it to intricate Cu masks. The earliest published electroplating experiments were ˜1800 AD, immediately following the invention of the dc electrochemical battery by Volta. Chemical vapor deposition (CVD) of metal films was reported in 1649, atmospheric arc deposition of oxides (Priestley) in the mid-1760s, and atmospheric plasmas (Siemens) in 1857. Sols were produced in the mid-1850s (Faraday) and sol-gel films synthesized in 1885. Vapor phase film growth including sputter deposition (Grove, 1852), vacuum arc deposition ("deflagration," Faraday, 1857), plasma-enhanced CVD (Barthelot, 1869) and evaporation (Stefan, Hertz, and Knudsen, 1873-1915) all had to wait for the invention of vacuum pumps whose history ranges from ˜1650 for mechanical pumps, through ˜1865 for mercury pumps that produce ballistic pressures in small systems. The development of crystallography, beginning with Plato in 360 BC, Kepler in 1611, and leading to Miller indices (1839) for describing orientation and epitaxial relationships in modern thin film technology, was already well advanced by the 1780s (Haüy). The starting point for the development of heterogeneous thin film nucleation theory was

  10. Potiguar tourism that came to lose 100 thousand landings!

    Directory of Open Access Journals (Sweden)

    Maria Valéria Araujo

    2016-08-01

    Full Text Available The Case Study "The Rio Grande do Norte tourism which has suffered a loss of '100,000 arrivals'" describes a peculiar and challenging scenario in which the tourist destination of Natal lies. Thus, this case study presents the investment history of Natal into tourism as well as discuss the decisions that should be taken by the current Tourism Secretary of Natal faced with the difficulties regarding the reduced of this destination among international tourists. This reduction took place mainly after the global economic crisis with a reduction of charter flights for (from Natal. Infrastructure and public safety issues also contributed to a reduction in the number of visitors to the city. Within this context a reflection on the scenario in which Natal lies with the objective of demonstrating the importance of the implementation of public policies, tourism marketing, an analysis of internal and external environments of the destination, and the establishment of competitive advantages is proposes. For the preparation of this case study realistic about tourism data was collected from newspapers, magazines and scientific papers. This case study can be applied in Graduate or postgraduate courses in Business Administration, Marketing and Tourism.

  11. [Family history of liver cancer increases the risk of liver cancer incidence: a 20-year prospective cohort study in Qidong, China].

    Science.gov (United States)

    Sun, Yan; Tu, Hong; Lu, Peixin; Wang, Jinbing; Wu, Yan; Zhang, Qinan; Qian, Gengsun; Chen, Taoyang

    2014-10-01

    To evaluate whether first-degree family history of liver cancer plays a role in liver cancer incidence by prospective evaluation of a patient cohort in Qidong, China over a 20-year period. In May 1992, 708 hepatitis B surface antigen (HBsAg) carriers and 730 HBsAg-negadve controls from Qidong city were enrolled for participation in a prospective cohort study ending in November 2012.Follow-up was carried out every 6 to 12 months, and evaluations included serum assays to measure concentrations of alpha fetoprotein (AFP), HBsAg and alanine aminotransferase (ALT), as well as abdominal ultrasound to assess liver disease.The relationship between baseline (study entry) information of patients with first-degree family history of liver cancer and liver cancer incidence during the two decades of study was statistically assessed. There were 172 newly diagnosed liver cancer cases in the cohort during 25 753 person-years (py) of follow-up, representing an incidence of 667.88/100 000 py.The incidence rates of liver cancer among participants with or without liver cancer family history were 1 244.36/100 000 py and 509.70/100 000 py respectively, and the between-group difference reached the threshold for statistical significance (P less than 0.01, Relative Risk (RR):2.44, 95% Confidence Interval (CI):1.80-3.31).The incidence rates of liver cancer among participants who had a sibling with liver cancer and participants who had a parent with liver cancer were not significantly different (P > 0.05), but the liver cancer incidence among participants who had a mother with liver cancer was significantly higher than that of participants who had a father with liver cancer (P history, 56.52% (39/69) were diagnosed before 50 years old, and this rate was significantly higher than that of participants without a family history of liver cancer (40.78%, 42/103, P less than 0.05).The incidence rate of liver cancer among the participants who were family history-positive and HBsAg-positive was

  12. Twenty-Five year (1982-2007) history of lodgepole pine dwarf mistletoe animal vectors and ethephon control on the Fraser Experimental Forest in Colorado

    Science.gov (United States)

    Thomas. Nicholls

    2009-01-01

    This is a summary of the 25-year history of studies of mammal and bird vectors of lodgepole pine dwarf mistletoe (Arceuthobium americanum), ethephon control of dwarf mistletoe, and the ecology of the most important dwarf mistletoe vector, the gray jay (Persisoreus canadensis), on the USDA Forest Service, Fraser Experimental Forest...

  13. CAC-RA1 1958-1998. The first years of the Constituyentes Atomic Center (CAC). History of the first Argentine nuclear reactor (RA-1)

    International Nuclear Information System (INIS)

    Forlerer, Elena; Palacios, Tulio A.

    1998-01-01

    After giving the milestones of the development of the Constituyentes Atomic Center since 1957, the history of the construction of the first nuclear reactor (RA-1) in Argentina, including the local fabrication of its fuel elements, is surveyed. The RA-1 reached criticality on January 17, 1958. The booklet commemorates the 40th year of the reactor operation

  14. Triumphs Show: What Makes Art History? Year 7 Exploit the Resources of the Victoria and Albert Museum's Medieval Gallery to Create and Curate Their Own Answer

    Science.gov (United States)

    Copsey, Sarah

    2014-01-01

    What do 14 Year 7 students, an art teacher, a history teacher and the Victoria and Albert Museum have in common? They are all part of the "Stronger Together" Museum Champion project run by The Langley Academy and the River & Rowing Museum and supported by Arts Council England, designed to engage students, teachers and museum staff…

  15. Two thousand years of geomagnetic field direction over central Europe revealed by indirect measurements

    Science.gov (United States)

    Márton, Péter

    2010-04-01

    Supplemented by 32 new directions, the Hungarian archaeomagnetic data set now consists of 217 archaeologically dated directions ranging in age from 300 BC to 1800 AD. From this data set, reference curves of secular variation of the geomagnetic field direction were computed using hierarchical modelling and curve estimation by moving average technique. Thanks to some of the new data, the gap in the earlier reference curves around 500 AD has now been filled up. For comparison's sake, directional records of comparable length from central Europe were also processed by the same curve building method. For this purpose, all dated directional data (declination and inclination with statistics) were drawn from the GEOMAGIA50 database for France, Germany, the Ukraine and Moldavia, Bulgaria and Italy and transferred via their virtual geomagnetic poles to a reference point of their respective countries. The resulting reference curves, including those for Hungary, show more or less similar temporal behaviour to the corresponding CALS7K.2 model curves (also available from the GEOMAGIA50 database), but significant deviations from the low-order CALS7K.2 predictions are also discernible owing to the likely presence of additional higher-order complications in the regional field. Therefore, the regional field and its secular variation are suggested to be approximated by the reference rather than the predicted curves. At any other location within the study area, the direction of the regional field can be obtained by spatial interpolation from the reference curves as illustrated by isogonic and isoclinic maps shown for selected times. Local time-series of interpolated directions for other central European countries lacking reference curves might serve as master curves for magnetic dating.

  16. The ten-thousand year fever: rethinking human and wild primate malarias

    National Research Council Canada - National Science Library

    Cormier, Loretta A

    2011-01-01

    ... relationships between culture and environment that shape the trajectory of a parasite. She argues against the entrenched distinction between human and non-human malarias, using ethnoprimatology to develop a new understanding of cross-species exchange...

  17. The ten-thousand year fever: rethinking human and wild primate malarias

    National Research Council Canada - National Science Library

    Cormier, Loretta A

    2011-01-01

    .... In this pathbreaking book Loretta Cormier integrates a wide range of data from molecular biology, ethnoprimatology, epidemiology, ecology, anthropology, and other fields to reveal the intimate...

  18. High-level-waste containment for a thousand years: unique technical and research problems

    International Nuclear Information System (INIS)

    Davis, M.S.

    1982-01-01

    In the United States the present policy for disposal of high level nuclear wastes is focused on isolation of solidified wastes in a mined geologic repository. Safe isolation is to be achieved by utilizing both natural and man-made barriers which will act in concert to assure the overall conservative performance of the disposal system. The incorporation of predictable man-made barriers into the waste disposal strategy has generated some new and unique problems for the scientific community

  19. A thousand years of earthquakes in France. Catalogue of epicenters parameters and references

    International Nuclear Information System (INIS)

    Lambert, J.; Levret-Albaret, A.; Cushing, M.

    1996-11-01

    Considered as negligible at the worldwide scale and weak at the European scale, the seismicity of the French territory is typical of intra-continental areas with low level of crustal deformations. Therefore, the feedback period of major seismic events is long, and the seismic risk and its consequences on buildings is complex to evaluate. In todays context of urban areas development and because the number of industrial installations and collective equipments is increasing, the protection against this natural disaster even for small magnitude earthquakes is becoming a more and more important task. This statement led the French authorities to take great care of the seismic risk when the French electronuclear program started. Because of the incomplete geophysical, tectonic and seismic data available, a huge program of seismicity revision started in 1975 and has been carried out by the French Bureau of Geologic and Mining Research (BRGM) with the joint financial help of Electricite de France (EdF) and the French Institute for Protection and Nuclear Safety (IPSN). This work has led to the creation of the specific SIRENE database for the collection French historical macro-seismic data. This book is a catalogue of the major characteristics of historical French earthquakes (geographic coordinates, intensities, observations linked and datings) with respect to macro-seismic epicenters. This catalogue is completed by a bibliographic index, a list of references, and statistical diagrams. (J.S.)

  20. Traditional medicinal plant use in Northern Peru: tracking two thousand years of healing culture.

    Science.gov (United States)

    Bussmann, Rainer W; Sharon, Douglas

    2006-11-07

    This paper examines the traditional use of medicinal plants in Northern Peru, with special focus on the Departments of Piura, Lambayeque, La Libertad, Cajamarca, and San Martin. Northern Peru represents the center of the old Central Andean "Health Axis," stretching from Ecuador to Bolivia. The roots of traditional healing practices in this region go at least as far back as the Moche period (AC 100-800). Although about 50% of the plants in use reported in the colonial period have disappeared from the popular pharmacopoeia, the plant knowledge of the population is much more extensive than in other parts of the Andean region. 510 plant species used for medicinal purposes were collected, identified and their vernacular names, traditional uses and applications recorded. The families best represented were Asteraceae with 69 species, Fabaceae (35), Lamiaceae (25), and Solanaceae (21). Euphorbiaceae had twelve species, and Apiaceae and Poaceae 11 species. The highest number of species was used for the treatment of "magical/ritual" ailments (207 species), followed by respiratory disorders (95), problems of the urinary tract (85), infections of female organs (66), liver ailments (61), inflammations (59), stomach problems (51) and rheumatism (45). Most of the plants used (83%) were native to Peru. Fresh plants, often collected wild, were used in two thirds of all cases, and the most common applications included the ingestion of herb decoctions or the application of plant material as poultices.

  1. Dispersal of thermophilic Desulfotomaculum endospores into Baltic Sea sediments over thousands of years

    DEFF Research Database (Denmark)

    Rezende, Julia Rosa de; Kjeldsen, Kasper Urup; Hubert, Casey RJ

    2013-01-01

    S rRNA and of the dissimilatory (bi)sulfite reductase (dsrAB) genes within the endospore-forming SRB genus Desulfotomaculum. The thermophilic Desulfotomaculum community in Aarhus Bay sediments consisted of at least 23 species-level 16S rRNA sequence phylotypes. In two cases, pairs of identical 16S r......RNA and dsrAB sequences in Arctic surface sediment 3000km away showed that the same phylotypes are present in both locations. Radiotracer-enhanced most probable number analysis revealed that the abundance of endospores of thermophilic SRB in Aarhus Bay sediment was ca. 104 per cm3 at the surface and decreased...... in water masses preceding sedimentation. The sources of these thermophiles remain enigmatic, but at least one source may be common to both Aarhus Bay and Arctic sediments....

  2. The ten-thousand year fever: rethinking human and wild primate malarias

    National Research Council Canada - National Science Library

    Cormier, Loretta A

    2011-01-01

    .... She also shows how current human-environment interactions, including deforestation and development, create the potential for new forms of malaria to threaten human populations. This book is a model of interdisciplinary integration that will be essential reading in fields from anthropology and biology to public health"--Provided by publisher.

  3. A Simple Physics-Based Model Predicts Oil Production from Thousands of Horizontal Wells in Shales

    KAUST Repository

    Patzek, Tadeusz

    2017-10-18

    Over the last six years, crude oil production from shales and ultra-deep GOM in the United States has accounted for most of the net increase of global oil production. Therefore, it is important to have a good predictive model of oil production and ultimate recovery in shale wells. Here we introduce a simple model of producing oil and solution gas from the horizontal hydrofractured wells. This model is consistent with the basic physics and geometry of the extraction process. We then apply our model thousands of wells in the Eagle Ford shale. Given well geometry, we obtain a one-dimensional nonlinear pressure diffusion equation that governs flow of mostly oil and solution gas. In principle, solutions of this equation depend on many parameters, but in practice and within a given oil shale, all but three can be fixed at typical values, leading to a nonlinear diffusion problem we linearize and solve exactly with a scaling

  4. Jane Smiley’s A Thousand Acres (1991 and Archival Reimaginations of Eco-Cosmopolitanism

    Directory of Open Access Journals (Sweden)

    Scott Hicks

    2013-05-01

    Full Text Available This article blurs the boundaries of literature, agriculture, public history, grassroots political activism, and public policymaking in order to problematize the current eco-cosmopolitan trajectory of ecocritical theory, a trajectory promulgated by Ursula K. Heise in important essays and books. Foregrounding the voices of grassroots environmentalists as well as the public-relations campaigns of multinational agribusiness trade groups, materials collected in the special collections of Iowa State University, the article resituates Smiley’s prizewinning novel and offers a complication of current conceptualizations of eco-cosmopolitanism. The article aims to show the struggles of rural people to embrace a planetary consciousness—a global awareness that can paradoxically foreground as well as participate in the continued ecological devastation of the landscapes these activists hold dear. These local voices underscore the challenges human subjects face in articulating and narrating environmental relationships—even despite their intimate proximity to these landscapes. Just as Thousand Acres’s mastery of a complex environmentalist voice is hard won, so too is that of dozens of rural people across the world. The challenges they face demand the close attention of the environmental humanities, not only to deeply engage appropriate texts, but to engage them with a framework that expands the orchestra and zeros in on the critical problems of global agriculture, planetary health, and human rights.

  5. What Do We Learn from 40 Years of History? Issues in VET Teacher Education from Kangan to Today

    Science.gov (United States)

    Harris, Roger

    2017-01-01

    Francesca Beddie asserts that "history … currently plays little part in governmental processes and does not meet its potential as a contributor to wider policy debate." Adopting a book-ends approach in analysing two critical periods of time four decades apart--1974-81 and 2011-16--this paper examines key issues in Australian VET teacher…

  6. Recognizing history in range ecology: 100 years of science and management on the Santa Rita Experimental Range

    Science.gov (United States)

    Nathan F. Sayre

    2003-01-01

    At the centennial of the Santa Rita Experimental Range, historical analysis is called for on two levels. First, as a major site in the history of range ecology, the Santa Rita illuminates past successes and failures in science and management and the ways in which larger social, economic, and political factors have shaped scientific research. Second, with the turn away...

  7. Yearly hypertension screening in women with a history of pre-eclampsia : a cost-effectiveness analysis

    NARCIS (Netherlands)

    Drost, J T; Grutters, J P C; van der Wilt, G-J; van der Schouw, Y T|info:eu-repo/dai/nl/073449253; Maas, A H E M

    2015-01-01

    BACKGROUND: Women with a history of preeclampsia are at increased risk for future hypertension and cardiovascular disease (CVD); until now it is not clear whether preventive measures are needed. METHODS: A decision-analytic Markov model was constructed to evaluate healthcare costs and effects of

  8. Past 20,000-year history of Himalayan aridity: Evidence from oxygen isotope records in the Bay of Bengal

    Digital Repository Service at National Institute of Oceanography (India)

    Chauhan, O.S.

    Late Quaternary climate history of the Himalayas is inferred from sea surface salinity (SSS) changes determined from the oxygen isotope in planktonic foraminifers, in a turbidity-free, 14C-dated core from the Bay of Bengal. The heaviest d18O...

  9. LIAS light – Towards the ten thousand species milestone

    Directory of Open Access Journals (Sweden)

    Gerhard Rambold

    2014-01-01

    Full Text Available Over the past 12 years, the lichen trait database LIAS light as a component of the LIAS information system, has grown to a considerable pool of descriptive data based on 71 different qualitative, quantitative, and text characters, for nearly 10.000 lichen taxa, being phylogenetically arranged according to the MycoNet classification. It includes information on morphological, ecological and chemical traits. Multilinguality or internationalization options have become a central challenge of the project. At present, 18 language versions of the database and web interface exist. LIAS light data are accessible in DELTA format and to be used locally and web browser-based, via NaviKey applet.

  10. Depositional history and tectonic regimes within and in the margins of the Fennoscandian shield during the last 1300 million years

    International Nuclear Information System (INIS)

    Paulamaeki, S.; Kuivamaeki, A.

    2006-05-01

    This report is a literature review, which describes the occurrences of Meso- and Neoproterozoic and Phanerozoic sedimentary rocks in Finland and their depositional history The report also summarizes the tectonic and magmatic events within and in the margins of the Fennoscandian Shield during the last 1200 - 1300 million years. Mesoproterozoic (Middle Riphean) and Neoproterozoic (Late Vendian) sandstones and siltstones are presently found only in some tectonically protected basins, e.g., Satakunta and Muhos grabens, Bothnian Sea basin and Bothnian Bay basin, or in the impact structures, but they may have originally distributed over a much larger area. During the Lower and Middle Cambrian, arenaceous and argillaceous sediments were probably deposited in most of the western, southern and central Finland. During the Ordovician, carbonates were deposited in an epicontinental sea with repeated transgressions and regressions. In several occasions, the Bothnian Sea and Aaland Sea basins, as well as southern and south-western Finland were covered by the sea, and in the Middle Ordovician, the sea reached as far as central Finland. No Late Palaeozoic (Silurian to Permian) sedimentary rocks have been recognized. The apatite fission track studies indicate, however, that extensive Silurian to Devonian deposits most likely covered large parts of the Fennoscandian Shield, with an estimated thickness of 3 - 4 km in Sweden and ca. 1 km in Finland. In eastern Lapland, the clay bed of Akanvaara was deposited in early Tertiary (Eocene) under marine conditions. The Mesoproterozoic tectonics was dominated by the Sveconorwegian orogeny (ca. 1250 - 900 Ma), which mainly affected the present south-western Sweden and southern Norway. In Finland, the 'Postjotnian' olivine diabases, dated at 1270 - 1250 Ma, are considered to be connected to the initial rifting at the onset of the orogeny. After the Sveconorwegian orogeny, the Fennoscandian Shield was part of the worldwide supercontinent

  11. Bitola Destination for Cultural Tourism – 7000 Years of History – (From Gurgur through to Heraclea Bitola)

    OpenAIRE

    Dimitrov, Nikola

    2015-01-01

    Bitola is a major city in the country with several millennium history. It is a city which played hundreds of important historical events, town center of provinces, cities that were born, lived or resided important historical figures, and the city its cultural - historical heritage tourist successfully managed. In Bitola, today, are the most important tourist valorized cultural - historical monuments, events and ambient parts. Bitola, the more tourism fairs in Europe...

  12. Case Study: A Picture Worth a Thousand Words? Making a Case for Video Case Studies

    Science.gov (United States)

    Pai, Aditi

    2014-01-01

    A picture, they say, is worth a thousand words. If a mere picture is worth a thousand words, how much more are "moving pictures" or videos worth? The author poses this not merely as a rhetorical question, but because she wishes to make a case for using videos in the traditional case study method. She recommends four main approaches of…

  13. Histories of terrestrial planets

    International Nuclear Information System (INIS)

    Benes, K.

    1981-01-01

    The uneven historical development of terrestrial planets - Mercury, Venus, Earth, Moon and Mars - is probably due to the differences in their size, weight and rotational dynamics in association with the internal planet structure, their distance from the Sun, etc. A systematic study of extraterrestrial planets showed that the time span of internal activity was not the same for all bodies. It is assumed that the initial history of all terrestrial planets was marked with catastrophic events connected with the overall dynamic development of the solar system. In view of the fact that the cores of small terrestrial bodies cooled quicker, their geological development almost stagnated after two or three thousand million years. This is what probably happened to the Mercury and the Moon as well as the Mars. Therefore, traces of previous catastrophic events were preserved on the surface of the planets. On the other hand, the Earth is the most metamorphosed terrestrial planet and compared to the other planets appears to be atypical. Its biosphere is significantly developed as well as the other shell components, its hydrosphere and atmosphere, and its crust is considerably differentiated. (J.P.)

  14. Hypnotherapy for irritable bowel syndrome: an audit of one thousand adult patients.

    Science.gov (United States)

    Miller, V; Carruthers, H R; Morris, J; Hasan, S S; Archbold, S; Whorwell, P J

    2015-05-01

    Gut-focused hypnotherapy improves the symptoms of irritable bowel syndrome (IBS) with benefits being sustained for many years. Despite this, the technique has not been widely adopted by healthcare systems, possibly due to relatively small numbers in published studies and uncertainty about how it should be provided. To review the effect of hypnotherapy in a large cohort of refractory IBS patients. One thousand IBS patients fulfilling Rome II criteria, mean age 51.6 years (range 17-91 years), 80% female, receiving 12 sessions of hypnotherapy over 3 months, were studied. The primary outcome was a 50 point reduction in the IBS Symptom Severity Score. The fall in scores for Noncolonic Symptoms, Quality of Life and Anxiety or Depression, were secondary outcomes. The Federal Drug Administration's recommended outcome of a 30% or more reduction in abdominal pain was also recorded. Overall, 76% met the primary outcome which was higher in females (females: 80%, males: 62%, P hypnotherapy is an effective intervention for refractory IBS. © 2015 John Wiley & Sons Ltd.

  15. BITOLA DESTINATION FOR CULTURAL TOURISM – 7000 YEARS OF HISTORY – (FROM GURGUR THROUGH TO HERACLEA BITOLA

    Directory of Open Access Journals (Sweden)

    Nikola V. Dimitrov

    2015-01-01

    Full Text Available Bitola is a major city in the country with several millennium history. It is a city which played hundreds of important historical events, town center of provinces, cities that were born, lived or resided important historical figures, and the city its cultural - historical heritage tourist successfully managed. In Bitola, today, are the most important tourist valorized cultural - historical monuments, events and ambient parts. Bitola, the more tourism fairs in Europe, successfully launched its cultural - historical heritage and cultural events, becoming the most avant-garde tourist destination in cultural tourism in the Balkans.

  16. Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994

    International Nuclear Information System (INIS)

    1995-05-01

    Dr. George Voelz was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). This oral history covers Dr. Voelz's research on Manhattan Engineering District plutonium workers, the acute and long term effects of radiation, his inhalation studies, and his activities at the 1961 INL reactor accident (SL-1 Reactor). After a brief biographical sketch, Dr. Voelz his remembrances on tissue studies of plutonium workers, the plutonium injection studies of 1945-1946, the controlled environmental radioiodine tests of 1963-1968, and tracer studies with human volunteers at Los Alamos. Dr. Voelz states his opinions concerning misconceptions about the Los Alamos Human Radiation Experiments

  17. First Episode of Psychosis in a Middle-Aged Patient with a 14-Year History of Conversion Disorder

    Directory of Open Access Journals (Sweden)

    Vaios Peritogiannis

    2014-01-01

    Full Text Available We present a case of a middle-aged male patient with a long history of conversion disorder and histrionic personality, who presented with newly onset psychotic symptoms while being engaged to treatment with a community mental health team in a primary care setting. The symptoms could not be attributed to an organic cause. After a short course of olanzapine treatment which caused adverse effects, the symptomatology responded well to low dose amisulpride. Conversion symptoms were stable throughout the psychotic episode. This case illustrates the complex interplay between disorders classified in different categories (somatoform versus psychotic disorders.

  18. Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-01

    Dr. George Voelz was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). This oral history covers Dr. Voelz`s research on Manhattan Engineering District plutonium workers, the acute and long term effects of radiation, his inhalation studies, and his activities at the 1961 INL reactor accident (SL-1 Reactor). After a brief biographical sketch, Dr. Voelz his remembrances on tissue studies of plutonium workers, the plutonium injection studies of 1945-1946, the controlled environmental radioiodine tests of 1963-1968, and tracer studies with human volunteers at Los Alamos. Dr. Voelz states his opinions concerning misconceptions about the Los Alamos Human Radiation Experiments.

  19. Marital history from age 15 to 40 years and subsequent 10-year mortality: a longitudinal study of Danish males born in 1953

    DEFF Research Database (Denmark)

    Lund, Rikke; Holstein, Bjørn Evald; Osler, Merete

    2004-01-01

    BACKGROUND: The aims of the present study are to analyse the association between marital status at age 24, 29, 34, and 39 years and subsequent mortality in a cohort of men born in 1953 (sensitive period); to study the impact of number of years married, number of years divorced/widowed, and number...... a strong protective effect of being married compared with never being married or divorced/widowed at every age. The association increased in strength with increasing age. Number of years divorced was associated with increased mortality risk in a dose-dependent manner at age 34 and 39 years. One or more...... and cumulated marital periods, especially cumulated periods divorced/widowed are strong independent predictors of mortality among younger males....

  20. History of radiation protection in the Czech Republic. Ten years of the National Radiation Protection Institute, 1995-2005

    International Nuclear Information System (INIS)

    Drabkova, A.

    2006-01-01

    The first part of the publication, highlighting the history of radiation protection in the country which today is the Czech Republic, is divided into the following sections: Inception of the field of science and applications 'Protection from ionizing radiation'; Beginnings of work with ionizing radiation in the Czech lands; Formulation of the first health physics and radiation protection requirements in the Czech lands; Beginnings of institutionalization of radiation protection in Czechoslovakia after World War II; The Clinic and Institute of Occupational Medicine in Prague; Institute of Occupational Hygiene and Occupational Diseases in Prague and the regional Institute of Occupational Hygiene and Occupational Diseases in Bratislava; Peaceful uses of atomic energy in Czechoslovakia; First man-made radioisotopes in Czechoslovakia; Health rules and standards applicable to work with ionizing radiation; The responsibilities of the Ministry of Health in the area of health physics and radiation protection within peaceful uses of atomic energy in the Czech Socialist Republic; Research Institute of Health Physics; Institute of Occupational Hygiene and Prevention of Occupational Diseases in the Mining and Processing of Radioactive Raw Materials; Health physics and radiation protection in sectorial and national research plans; Health Physics Centre, Institute of Hygiene and Epidemiology; National Radiation Protection Institute (as a subsidiary of the State Office for Nuclear Safety). The second part of the publication gives details of the recent history of the National Radiation Protection Institute. (P.A.)

  1. Sixty-Five Million Years of Change in Temperature and Topography Explain Evolutionary History in Eastern North American Plethodontid Salamanders.

    Science.gov (United States)

    Barnes, Richard; Clark, Adam Thomas

    2017-07-01

    For many taxa and systems, species richness peaks at midelevations. One potential explanation for this pattern is that large-scale changes in climate and geography have, over evolutionary time, selected for traits that are favored under conditions found in contemporary midelevation regions. To test this hypothesis, we use records of historical temperature and topographic changes over the past 65 Myr to construct a general simulation model of plethodontid salamander evolution in eastern North America. We then explore possible mechanisms constraining species to midelevation bands by using the model to predict plethodontid evolutionary history and contemporary geographic distributions. Our results show that models that incorporate both temperature and topographic changes are better able to predict these patterns, suggesting that both processes may have played an important role in driving plethodontid evolution in the region. Additionally, our model (whose annotated source code is included as a supplement) represents a proof of concept to encourage future work that takes advantage of recent advances in computing power to combine models of ecology, evolution, and earth history to better explain the abundance and distribution of species over time.

  2. Materials for the history of the Ospedale Maggiore of Milan: the Chapter resolutions of the years 1456-1498

    Directory of Open Access Journals (Sweden)

    Giuliana Albini

    2011-04-01

    Full Text Available The history of charity and assistance in Milan at the end of the Middle Ages has as basic term of reference the documentary sources of the Ospedale Maggiore, the new great hospital result of a long process of reform that took place in the course of the 15th century. The Chapter of the Ospedale Maggiore became a management centre which planned and controlled the activities of other charitable-attendance structures, the most important of them represented in the corporative administrative body of the Ospedale Maggiore itself. The Ospedale Maggiore Chapter left evidence of its meetings and decisions in more than 3000 proceedings, registered in seven records. The board resolutions of the Ospedale Maggiore of Milan are a basic source for the history of hospitals of all Lombardy. Moreover, they shed light on economic, social and political dynamics of the Duchy of Milan at the end of Quattrocento: the organization of the Ospedale Maggiore board highlights on politics and strategies of the ruling groups of Milan and of the Sforza dynasty as well. Object of this work is the edition, in the form of regestum, of the Ospedale Maggiore Chapter resolutions; a map of the country estate, land, farms, mills, of the Ospedale Maggiore, is edited too.

  3. [Value of history and clinical and laboratory data for the diagnosis of dehydration due to acute diarrhea in children younger than 5 years].

    Science.gov (United States)

    Pruvost, Isabelle; Dubos, François; Aurel, Marie; Hue, Valérie; Martinot, Alain

    2008-04-01

    Acute diarrhea is frequent, costly because of the number of hospital admissions required, and sometimes serious, even fatal to children in France. The clinical diagnosis of dehydration is difficult, but essential to determine management. To summarize the published data on the value of clinical history, clinical signs and laboratory results for diagnosing dehydration during acute diarrhea in young (1 month-5 years) non-malnourished children. Four databases (Medline, INIST, Ovid, and Cochrane) were searched through November 2006, with the key words "dehydration" subcategories "diagnosis, or etiology, or history", "diarrhea" subcategory "diagnosis", and age limits "infant or preschool child". We selected the articles and reviews that included as an endpoint for dehydration "weight gain > 5% after recovery" (the gold standard). Thirteen studies were selected. No single clinical history item, clinical sign or laboratory value was sufficient to discriminate between children with and without dehydration. The reproducibility of clinical signs varied substantially between studies. Persistent skin folds and signs of vasoconstriction contributed the most information, with good specificity but sensitivity number of subjects. The diagnosis of dehydration due to acute diarrhea in young children depends on the number of signs present, since no individual element of clinical history, clinical picture or laboratory tests distinguished dehydration. Other studies are necessary.

  4. Thousand Questions

    DEFF Research Database (Denmark)

    2012-01-01

    (perhaps as an expanded Turing test) on its listeners. These questions are extracted in real-time from Twitter with the keyword search of the ‘?’ symbol to create a spatio-temporal experience. The computerized voice the audience hears is a collective one, an entanglement of humans and non...

  5. PEAT ACCRETION HISTORIES DURING THE PAST 6000 YEARS IN MARSHES OF THE SACRAMENTO - SAN JOAQUIN DELTA, CALIFORNIA, USA

    Energy Technology Data Exchange (ETDEWEB)

    Drexler, J Z; de Fontaine, C S; Brown, T A

    2009-07-20

    Peat cores were collected in 4 remnant marsh islands and 4 drained, farmed islands throughout the Sacramento - San Joaquin Delta of California in order to characterize the peat accretion history of this region. Radiocarbon age determination of marsh macrofossils at both marsh and farmed islands showed that marshes in the central and western Delta started forming between 6030 and 6790 cal yr BP. Age-depth models for three marshes were constructed using cubic smooth spline regression models. The resulting spline fit models were used to estimate peat accretion histories for the marshes. Estimated accretion rates range from 0.03 to 0.49 cm yr{sup -1} for the marsh sites. The highest accretion rates are at Browns Island, a marsh at the confluence of the Sacramento and San Joaquin rivers. Porosity was examined in the peat core from Franks Wetland, one of the remnant marsh sites. Porosity was greater than 90% and changed little with depth indicating that autocompaction was not an important process in the peat column. The mean contribution of organic matter to soil volume at the marsh sites ranges from 6.15 to 9.25% with little variability. In contrast, the mean contribution of inorganic matter to soil volume ranges from 1.40 to 8.45% with much greater variability, especially in sites situated in main channels. These results suggest that marshes in the Delta can be viewed as largely autochthonous vs. allochthonous in character. Autochthonous sites are largely removed from watershed processes, such as sediment deposition and scour, and are dominated by organic production. Allochthonous sites have greater fluctuations in accretion rates due to the variability of inorganic inputs from the watershed. A comparison of estimated vertical accretion rates with 20th century rates of global sea-level rise shows that currently marshes are maintaining their positions in the tidal frame, yet this offers little assurance of sustainability under scenarios of increased sea-level rise in

  6. The History of Stuttering by 7 Years of Age: Follow-Up of a Prospective Community Cohort

    Science.gov (United States)

    Kefalianos, Elaina; Onslow, Mark; Packman, Ann; Vogel, Adam; Pezic, Angela; Mensah, Fiona; Conway, Laura; Bavin, Edith; Block, Susan; Reilly, Sheena

    2017-01-01

    Purpose: For a community cohort of children confirmed to have stuttered by the age of 4 years, we report (a) the recovery rate from stuttering, (b) predictors of recovery, and (c) comorbidities at the age of 7 years. Method: This study was nested in the Early Language in Victoria Study. Predictors of stuttering recovery included child, family, and…

  7. Local History, Local Complexities: The First-Year Writing Curriculum at the University of Louisiana at Lafayette

    Science.gov (United States)

    Ratliff, Clancy

    2013-01-01

    This profile describes a new WPA's choice to work incrementally to assess an inherited, fledgling First-Year Writing curriculum at the University of Louisiana at Lafayette and change it over a three-year period with continual stakeholder involvement. The methods used for assessment were two rounds of instructor surveys and three rounds of direct…

  8. Emergency peripartum hysterectomy and risk factors by mode of delivery and obstetric history: a 10-year review from Helsinki University Central Hospital.

    Science.gov (United States)

    Macharey, Georg; Ulander, Veli-Matti; Kostev, Karel; Väisänen-Tommiska, Mervi; Ziller, Volker

    2015-11-01

    This study aims to estimate the occurrence of emergency peripartum hysterectomy (EPH) and to quantify its risk factors in connection with the mode of delivery and the obstetric history of patients at the Helsinki University Central Hospital, Finland. In a retrospective, matched case-control study we identified 124 cases of EPH from 2000 to 2010 at our hospital. These were matched with 248 control patients. The incidence rate of EPH was 9.9/10,000. Patients whose current delivery was vaginal, and had a cesarean section (CS) in their history had a six-fold risk for EPH. Women who underwent their first CS had a nine times higher risk, while patients who currently underwent CS and had a history of previous CS, had a 22 times higher risk. Those who experienced prostaglandin-E1 induction had a five-fold risk. Maternal age >35 years, previous curettage, and twin pregnancy were identified as significant risk factors. In 41 cases, interventions to reduce bleeding were performed. Obstetric emergency training and guidelines for massive hemorrhage should be established in any delivery department. Moreover, all possible precautions should be taken to avoid the first CS if it is obstetrically unnecessary. Induction with prostaglandin-E1, maternal age >35 years, previous curettage, twin pregnancies, and early gestation were identified as risk factors for EPH.

  9. Species delimitation and phylogenetic reconstruction of the sinipercids (Perciformes: Sinipercidae) based on target enrichment of thousands of nuclear coding sequences.

    Science.gov (United States)

    Song, Shuli; Zhao, Jinliang; Li, Chenhong

    2017-06-01

    The sinipercids are freshwater fishes endemic to East Asia, mainly in China. Phylogenetic studies on the sinipercids have made great progress in the last decades, but interspecific relationships and evolutionary history of the sinipercids remain unresolved. Lack of distinctive morphological characters leads to problems in validating of some species, such as Siniperca loona. Moreover, genetic data are needed to delimitate species pairs with explicit hypothesis testing, such as in S. chuatsi vs. S. kneri and Coreoperca whiteheadi vs. C. liui. Here we reconstructed phylogeny of the sinipercids with an unprecedented scale of data, 16,943 loci of single-copy coding sequence data from nine sinipercid species, eight putative sister taxa and two outgroups. Targeted sequences were collected using gene enrichment and Illumina sequencing, yielding thousands of protein coding sequences and single nucleotide polymorphisms (SNPs) data. Maximum likelihood and coalescent species tree analyses resulted in identical and highly supported trees. We confirmed that the centrarchids are sister to the sinipercids. A monophyletic Sinipercidae with two genera, Siniperca and Coreoperca was also supported. Different from most previous studies, S. scherzeri was found as the most basal taxon to other species of Siniperca, which consists of two clades: a clade having S. roulei sister to S. chuatsi and S. kneri, and a clade consisting S. loona sister to S. obscura and S. undulata. We found that both S. loona and C. liui are valid species using Bayes factor delimitation (BFD ∗ ) based on SNPs data. Species delimitation also provided decisive support for S. chuatsi and S. kneri being two distinct species. We calibrated a chronogram of the sinipercids based on 100 loci and three fossil calibration points using BEAST, and reconstructed ancestral ranges of the sinipercids using Lagrange Analysis (DEC model) and Statistical Dispersal-Vicariance Analysis (S-DIVA) implemented in RASP. Divergence time

  10. LHC Computing Grid Project Launches intAction with International Support. A thousand times more computing power by 2006

    CERN Multimedia

    2001-01-01

    The first phase of the LHC Computing Grid project was approved at an extraordinary meeting of the Council on 20 September 2001. CERN is preparing for the unprecedented avalanche of data that will be produced by the Large Hadron Collider experiments. A thousand times more computer power will be needed by 2006! CERN's need for a dramatic advance in computing capacity is urgent. As from 2006, the four giant detectors observing trillions of elementary particle collisions at the LHC will accumulate over ten million Gigabytes of data, equivalent to the contents of about 20 million CD-ROMs, each year of its operation. A thousand times more computing power will be needed than is available to CERN today. The strategy the collabortations have adopted to analyse and store this unprecedented amount of data is the coordinated deployment of Grid technologies at hundreds of institutes which will be able to search out and analyse information from an interconnected worldwide grid of tens of thousands of computers and storag...

  11. Efficacy of the Incredible Years group parent program with families in Head Start who self-reported a history of child maltreatment.

    Science.gov (United States)

    Hurlburt, Michael S; Nguyen, Katherine; Reid, Jamila; Webster-Stratton, Carolyn; Zhang, Jinjin

    2013-08-01

    A prevention form of the Incredible Years (IY) parenting program was offered to parents who had children enrolled in Head Start, regardless of whether they reported having a history of child maltreatment. This study compared whether parenting practices and child behavioral outcomes differed in families who self reported a history of child maltreatment relative to families who did not. A site-randomized controlled trial of the IY parenting program was conducted in 64 classrooms in seven Head Start centers in Seattle, Washington. Families of 481 children took part in the study, with 335 in the IY condition and 146 in the control condition. Parenting practices and child behavior were measured by blinded raters through in-home observations and self-report questionnaires prior to the start of the IY program, in the spring after the IY program had concluded, and 12-18 months after study enrollment when children were in kindergarten. Analyses examine the impact of the IY program on parenting practices and children's behavior, exploring whether the program had differential impacts for parents with and without a self-reported history of child maltreatment. The IY program resulted in improvements along many parenting dimensions and on characteristics of observed child behavior. Program impacts were similar for parents who did and did not report a history of child maltreatment. However, parents with a reported history of prior maltreatment had greater initial room for improvement in areas such as harsh/critical parenting, nurturing/supportive parenting, and discipline competence than parents without such a history. The IY parenting program has positive impacts for parents who self-reported a history of child maltreatment. While similar benefits were observed for both groups of parents in this study, results support delivering evidence-based parenting programs of longer duration and higher intensity than often used by agencies serving parents in contact with child welfare

  12. "History, Theory and Ethics of Medicine": The Last Ten Years. A Survey of Course Content, Methods and Structural Preconditions at Twenty-nine German Medical Faculties.

    Science.gov (United States)

    Schildmann, Jan; Bruns, Florian; Hess, Volker; Vollmann, Jochen

    2017-01-01

    Objective: "History, Theory, Ethics of Medicine" (German: "Geschichte, Theorie, Ethik der Medizin", abbreviation: GTE) forms part of the obligatory curriculum for medical students in Germany since the winter semester 2003/2004. This paper presents the results of a national survey on the contents, methods and framework of GTE teaching. Methods: Semi-structured questionnaire dispatched in July 2014 to 38 institutions responsible for GTE teaching. Descriptive analysis of quantitative data and content analysis of free-text answers. Results: It was possible to collect data from 29 institutes responsible for GTE teaching (response: 76%). There is at least one professorial chair for GTE in 19 faculties; two professorial chairs or professorships remained vacant at the time of the survey. The number of students taught per academic year ranges from 350. Teaching in GTE comprises an average of 2.18 hours per week per semester (min: 1, max: 6). Teaching in GTE is proportionally distributed according to an arithmetic average as follows: history: 35.4%, theory 14.7% and ethics 49.9%. Written learning objectives were formulated for GTE in 24 faculties. The preferred themes of teaching in history, theory or ethics which according to respondents should be taught comprise a broad spectrum and vary. Teaching in ethics (79 from a max. of 81 possible points) is, when compared to history (61/81) and theory (53/81), attributed the most significance for the training of medical doctors. Conclusion: 10 years after the introduction of GTE the number of students and the personnel resources available at the institutions vary considerably. In light of the differences regarding the content elicited in this study the pros and cons of heterogeneity in GTE should be discussed.

  13. Sustaining Change: Successes, Challenges, and Lessons Learned from Twenty Years of Empowering Students through Community-Based Learning Capstones

    Science.gov (United States)

    Kerrigan, Seanna M.

    2015-01-01

    More than four thousand students engage in the community-based learning capstone program every year by enrolling in one of 240 senior-level courses that culminate their undergraduate education. In this article, the author shares the context and history of the program, its foundational principles and processes, and the nuts-and-bolts details of the…

  14. Reconstructing and analyzing China's fifty-nine year (1951–2009 drought history using hydrological model simulation

    Directory of Open Access Journals (Sweden)

    Z. Y. Wu

    2011-09-01

    Full Text Available The 1951–2009 drought history of China is reconstructed using daily soil moisture values generated by the Variable Infiltration Capacity (VIC land surface macroscale hydrology model. VIC is applied over a grid of 10 458 points with a spatial resolution of 30 km × 30 km, and is driven by observed daily maximum and minimum air temperature and precipitation from 624 long-term meteorological stations. The VIC soil moisture is used to calculate the Soil Moisture Anomaly Percentage Index (SMAPI, which can be used as a measure of the severity of agricultural drought on a global basis. We have developed a SMAPI-based drought identification procedure for practical uses in the identification of both grid point and regional drought events. As a result, a total of 325 regional drought events varying in time and strength are identified from China's nine drought study regions. These drought events can thus be assessed quantitatively at different spatial and temporal scales. The result shows that the severe drought events of 1978, 2000 and 2006 are well reconstructed, which indicates that the SMAPI is capable of identifying the onset of a drought event, its progression, as well as its termination. Spatial and temporal variations of droughts in China's nine drought study regions are studied. Our result shows that on average, up to 30% of the total area of China is prone to drought. Regionally, an upward trend in drought-affected areas has been detected in three regions (Inner Mongolia, Northeast and North from 1951–2009. However, the decadal variability of droughts has been weak in the rest of the five regions (South, Southwest, East, Northwest, and Tibet. Xinjiang has even been showing steadily wetter since the 1950s. Two regional dry centres are discovered in China as the result of a combined analysis on the occurrence of drought events from both grid points and drought study regions. The first centre is located in the area partially covered by the North

  15. Heathlands, fire and grazing. A palaeoenvironmental view of Las Hurdes (Cáceres, Spain history during the last 1200 years

    Directory of Open Access Journals (Sweden)

    Daniel Abel-Schaad

    2014-08-01

    Full Text Available Aim of study. The diachronic study of vegetation change through palynological analysis of sedimentary deposits is an essential tool both to design sound strategies on landscape  management and to understand its anthropogenic dynamics.Area of study. La Meseguera mire (Ladrillar, Cáceres, Spain is located in the Hurdes region in the western part of Iberian Central System and started to develop at the beginning of the Islamic period (ca. 770 cal AD, in an area widely dominated by heathland.  Material and methods. Pollen, non-pollen palynomorphs and charcoal accumulation rate (CHAR combined with historical data are useful indicators to assess the increasing role of human influence on vegetation.Main results. The use of fire and livestock husbandry represents the main drivers of landscape change in the course of the history. The establishment of forest afforestation plans, from the middle of 20th century, changed substantially the regional features. The sporadic presence of beech pollen is detected until 16th century, which implies the most western location in the Iberian Central Mountain System.Research highlights. The integration of pollen analysis and historical data is an essential tool when studying the changes in Holocene vegetation. These changes have been mainly driven by anthropogenic disturbances, more specifically by fire and livestock husbandry.Key Words: Anthropogenic dynamics; Central Mountain System; microcharcoals; non-pollen palynomorphs.  

  16. The natural history of a mistreated ipsilateral Galeazzi and Monteggia lesion: report of a case 39 years post-injury.

    Science.gov (United States)

    Kontakis, George M; Pasku, Dritan; Pagkalos, Joseph; Katonis, Pavlos G

    2008-08-01

    Galeazzi injury combined with ipsilateral Monteggia lesion is extremely rare. A 45-year-old male patient with a mistreated Galeazzi lesion combined with an ipsilateral Monteggia fracture at the age of 6 is presented. Thirty-nine years post-injury his elbow was asymptomatic and stable and his distal radioulnar and radiocarpal joints were also asymptomatic. The strength of the limb was equal to the unaffected contralateral upper limb and he was able to work manually as a waiter for the last 20 years without any problem. The only obvious defect was a 30 degrees lack of elbow flexion and a 10 degrees lack of forearm pronation in comparison to the normal side.

  17. Country Report: Civic and Citizenship Education in Italy: Thousands of Fragmented Activities Looking for a Systematization

    Directory of Open Access Journals (Sweden)

    Olga Bombardelli

    2017-07-01

    Full Text Available Purpose: In the present paper we describe how civic and citizenship education takes place in Italy, trying to identify strengths and weaknesses, with the aims both of understanding the situation and of identifying possible measures for improvement. Methods: The methodology implies an analysis of the official guidelines by the Ministry in this field, a short view of the research publications of the last 30 years, the informal observation of the daily teaching at school from the personal experience of the authors in Italy. Findings: First of all we study the concept of civic and citizenship education, and focus on the curriculum of civic and citizenship education (aims, teaching approaches, taught time, methods and means in the school system, including the school culture and the experiences of participation inside school; we investigate the teacher training and role, the informal and non-formal influences in this educational field, and conclude dealing with the student assessment, and the evaluation of the outcomes. In the daily practice there are thousands of activities for civic and citizenship education, but a systematic design is lacking.

  18. Effects of yearling sale purchase price, exercise history, lameness, and athletic performance on purchase price of Thoroughbreds at 2-year-old in-training sales.

    Science.gov (United States)

    Preston, Stephanie A; Brown, Murray P; Chmielewski, Terese L; Trumble, Troy N; Zimmel, Dana N; Hernandez, Jorge A

    2012-12-01

    To determine the effects of yearling sale purchase price, exercise history, lameness, and athletic performance (speed) on purchase price of 2-year-old in-training Thoroughbreds and to compare the distance exercised within 60 days prior to 2-year-old in-training sales between horses with high yearling sale purchase prices versus those with low yearling sale purchase prices and between horses with lameness during training and those without lameness during training. Prospective study. 51 Thoroughbreds. Thoroughbreds purchased at a yearling sale were trained prior to resale at 2-year-old in-training sales. Amount of exercise and lameness status during training and speed of horses at 2-year-old in-training sales were determined. Data were analyzed via the Wilcoxon rank sum test and ANOVA. Median purchase price of horses at 2-year-old in-training sales was $37,000. The 2-year-old in-training sale purchase price was associated with yearling sale purchase price and distance galloped within 60 days prior to and speed recorded at 2-year-old in-training sales. Horses with high yearling sale purchase prices typically had high 2-year-old in-training sale purchase prices, had low distances galloped within 60 days prior to 2-year-old in-training sales, and were classified as fast at 2-year-old in-training sales. Lameness alone was not associated with 2-year-old in-training sales purchase price. However, lameness was associated with a low distance galloped before 2-year-old in-training sales, particularly for horses with a high yearling sale purchase price; this finding suggested that yearling sale purchase price can affect training management decisions for horses with lameness.

  19. Attention problems among children with a positive family history of alcohol abuse or dependence and controls. Prevalence and course for the period from preteen to early teen years.

    Science.gov (United States)

    Barnow, Sven; Schuckit, Marc; Smith, Tom; Spitzer, Carsten; Freyberger, Harald-J

    2007-01-01

    This longitudinal study investigated the scope and course of attention problems over a period of time from preteen (ages 7-12 years) to early teen years (ages 13-17 years). We compared symptoms in subjects with and without a family history (FH) of alcohol abuse or dependence from among families without evidence of antisocial personality disorder. Evaluations of attention problems for the offspring were based on the Child Behavior Checklist and a validated semistructured interview carried out with the mother. The findings indicate no higher risk for attention problems and attention-deficit hyperactivity disorder (ADHD)-like symptoms in the children of families with an alcohol use disorder. Regarding the course of problems, the ADHD symptom count tended to decrease over time, especially for children without a FH of alcohol abuse or dependence. Further research will be needed to determine whether results can be replicated with families from different social strata and including subjects with the antisocial personality disorder.

  20. Suicides in the Canton of Lucerne over 5 years: subjects with and without psychiatric history and diagnosis.

    Science.gov (United States)

    Frei, Andreas; Bucher, Toralf; Walter, Marc; Ajdacic-Gross, Vladeta

    2013-03-25

    The majority of suicides had never had contact with the mental health care system. The aim of this study is to investigate the specific characteristics of this particular group. Coroners' files were examined for all 256 suicide victims in the Canton of Lucerne between 2002 and 2006, together with the data from the files of the public psychiatric institutions for individuals who had been registered as patients. The sociodemographic, suicidological and clinical variables of suicides who had been psychiatric patients were compared with those of other suicides. Within the latter group, suicides with remarks on their mental state in the coroner's files ("police diagnosis") were compared with suicides without such remarks. Assisted suicides (24/256 [9.4%]) were excluded from the comparative analysis. 151 (65.1%) of the remaining 232 suicides had never been registered by a public psychiatric service; 40 (26.5%) of these had a "police diagnosis". In the regression analysis intoxication as a suicide method, announcement of suicide and impaired health characterised suicides with an established psychiatric diagnosis, whereas suicides without a psychiatric diagnosis were more likely to be retired. Among the latter, those without a "police diagnosis" were more likely to have left a suicide note. Unexpectedly, the only difference between suicide methods with and without former contact with the mental health system was poisoning. Within the latter group, the subgroup without "police diagnosis" left more suicide notes. Further qualitative analyses of suicide notes might be useful in improving understanding of the motives of suicides without a manifest psychiatric history.

  1. Mental health indicators fifty years later: A population-based study of men with histories of child sexual abuse.

    Science.gov (United States)

    Easton, Scott D; Kong, Jooyoung

    2017-01-01

    Childhood sexual abuse (CSA) is a widely acknowledged trauma that affects a substantial number of boys/men and has the potential to undermine mental health across the lifespan. Despite the topic's importance, few studies have examined the long-term effects of CSA on mental health in middle and late life for men. Most empirical studies on the effects of CSA have been conducted with women, non-probability samples, and samples of young or emerging adults with inadequate control variables. Based on complex trauma theory, the current study investigated: a) the effect of CSA on mental health outcomes (depressive symptoms, somatic symptom severity, hostility) in late life for men, and b) the moderating effects of childhood adversities and masculine norms in the relationship between CSA and the three mental health outcomes. Using a population-based sample from the 2004-2005 Wisconsin Longitudinal Study, multivariate analyses found that CSA was positively related to both depressive and somatic symptoms and increased the likelihood of hostility for men who reported a history of CSA. Both childhood adversities and masculine norms were positively related to the three outcomes for the entire sample. Among CSA survivors, childhood adversities exerted a moderating effect in terms of depressive symptoms. Mental health practitioners should include CSA and childhood adversities in assessment and treatment with men. To more fully understand the effects of CSA, future studies are needed that use longitudinal designs, compare male and female survivors, and examine protective mechanisms such as social support. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history

    Directory of Open Access Journals (Sweden)

    Norman Ruthven Saunders

    2014-12-01

    Full Text Available Careful examination of relevant literature shows that many of the most cherished concepts of the blood-brain barrier are incorrect. These include an almost mythological belief in its immaturity that is unfortunately often equated with absence or at least leakiness in the embryo and fetus. The original concept of a blood-brain barrier is often attributed to Ehrlich; however, he did not accept that permeability of cerebral vessels was different from other organs. Goldmann is often credited with the first experiments showing dye (trypan blue exclusion from the brain when injected systemically, but not when injected directly into it. Rarely cited are earlier experiments of Bouffard and of Franke who showed methylene blue and trypan red stained all tissues except the brain. The term blood-brain barrier Blut-Hirnschranke is often attributed to Lewandowsky, but it does not appear in his papers. The first person to use this term seems to be Stern in the early 1920s. Studies in embryos by Stern & colleagues, Weed and Wislocki showed results similar to those in adult animals. These were well-conducted experiments made a century ago, thus the persistence of a belief in barrier immaturity is puzzling. As discussed in this review, evidence for this belief, is of poor experimental quality, often misinterpreted and often not properly cited. The functional state of blood-brain barrier mechanisms in the fetus is an important biological phenomenon with implications for normal brain development. It is also important for clinicians to have proper evidence on which to advise pregnant women who may need to take medications for serious medical conditions. Beliefs in immaturity of the blood-brain barrier have held the field back for decades. Their history illustrates the importance of taking account of all the evidence and assessing its quality, rather than selecting papers that supports a preconceived notion or intuitive belief. This review attempts to right the

  3. Lifestyle and health status in a sample of Swedish women four years after pregnancy: a comparison of women with a history of normal pregnancy and women with a history of gestational diabetes mellitus.

    Science.gov (United States)

    Persson, Margareta; Winkvist, Anna; Mogren, Ingrid

    2015-03-13

    Despite the recommendations to continue the regime of healthy food and physical activity (PA) postpartum for women with previous gestational diabetes mellitus (GDM), the scientific evidence reveals that these recommendations may not be complied to. This study compared lifestyle and health status in women whose pregnancy was complicated by GDM with women who had a normal pregnancy and delivery. The inclusion criteria were women with GDM (ICD-10: O24.4 A and O24.4B) and women with uncomplicated pregnancy and delivery in 2005 (ICD-10: O80.0). A random sample of women fulfilling the criteria (n = 882) were identified from the Swedish Medical Birth Register. A questionnaire was sent by mail to eligible women approximately four years after the pregnancy. A total of 444 women (50.8%) agreed to participate, 111 diagnosed with GDM in their pregnancy and 333 with normal pregnancy/delivery. Women with previous GDM were significantly older, reported higher body weight and less PA before the index pregnancy. No major differences between the groups were noticed regarding lifestyle at the follow-up. Overall, few participants fulfilled the national recommendations of PA and diet. At the follow-up, 19 participants had developed diabetes, all with previous GDM. Women with previous GDM reported significantly poorer self-rated health (SRH), higher level of sick-leave and more often using medication on regular basis. However, a history of GDM or having overt diabetes mellitus showed no association with poorer SRH in the multivariate analysis. Irregular eating habits, no regular PA, overweight/obesity, and regular use of medication were associated with poorer SRH in all participants. Suboptimal levels of PA, and fruit and vegetable consumption were found in a sample of women with a history of GDM as well as for women with normal pregnancy approximately four years after index pregnancy. Women with previous GDM seem to increase their PA after childbirth, but still they perform their PA at

  4. Environmental change in Crete : a 9000-year record of Holocene vegetation history and the effect of the Santorini eruption

    NARCIS (Netherlands)

    Bottema, S.; Sarpaki, A

    Palynological investigations were carried out in the coastal lowland of northwestern Crete, in the area of Lake Kournas. Results comprise the longest continuous vegetation record ( 9000 radiocarbon years) for Crete. From about 8500 to 7500 BP, open deciduous-oak forest occurred and appears to

  5. A Brief History of International Latin American Student Fraternities: A Movement That Lasted 86 Years (1889-1975)

    Science.gov (United States)

    Fajardo, Oliver

    2015-01-01

    An international Latin American student fraternity movement preceded the current Latino Greeks that are seen on college campuses today. This document provides new information that has not been published. The movement lasted 86 years and primarily served wealthy international Latin American students who came to the United States to study and, once…

  6. The rise and fall of traditional forest management in southern Moravia: A history of the past 700 years

    Czech Academy of Sciences Publication Activity Database

    Müllerová, Jana; Szabó, Péter; Hédl, Radim

    2014-01-01

    Roč. 331, Nov 1 (2014), s. 104-115 ISSN 0378-1127 R&D Projects: GA MŠk(CZ) EE2.3.20.0267 EU Projects: European Commission(XE) 278065 - LONGWOOD Institutional support: RVO:67985939 Keywords : archival sources * coppicing * GIS Subject RIV: EF - Botanics Impact factor: 2.660, year: 2014

  7. Restricted Consonant Inventories of 2-Year-Old Finnish Children with a History of Recurrent Acute Otitis Media

    Science.gov (United States)

    Haapala, Sini; Niemitalo-Haapola, Elina; Raappana, Antti; Kujala, Tiia; Kujala, Teija; Jansson-Verkasalo, Eira

    2015-01-01

    Many children experience recurrent acute otitis media (RAOM) in early childhood. In a previous study, 2-year-old children with RAOM were shown to have immature neural patterns for speech sound discrimination. The present study further investigated the consonant inventories of these same children using natural speech samples. The results showed…

  8. The natural history of cervical cancer in chinese women: results from an 11-year follow-up study in china using a multistate model.

    Science.gov (United States)

    Zhang, Shao-Kai; Kang, Le-Ni; Chang, Irene J; Zhao, Fang-Hui; Hu, Shang-Ying; Chen, Wen; Shi, Ju-Fang; Zhang, Xun; Pan, Qin-Jing; Li, Shu-Min; Qiao, You-Lin

    2014-07-01

    It is important to understand the natural history of cervical cancer, which has implications for cancer prevention and management. However, a dearth of studies on the long-term development of cervical cancer exists in China. We investigated the natural history of cervical cancer in Chinese women by creating a multistate model using 11 years of follow-up data from the Shanxi Province Cervical Cancer Screening Study I conducted from 1999 to 2010. In 1999, a total of 1,997 eligible women, ages 35 to 45 years, were enrolled in Xiangyuan County, Shanxi Province. Participants were followed up in 2005 and 2010, respectively. The average time a subject spent in CIN1 before transiting into another state was 1.4693 years [95% confidence interval (CI): 1.1215-1.9251] and the average time a subject spent in CIN2 was 2.9822 years (95% CI: 1.9790-4.4938). A subject's transition probability from CIN1 to normal increased with time. However, the transition probability from CIN1 to CIN2 was relatively lower, with 3-, 5-, and 10-year transition probabilities of 0.1415, 0.1066, and 0.0437. Comparison of 5-year transition probabilities between CIN2 to normal/CIN1 and CIN2 to CIN3(+) yielded a ratio of 2.74. Women with CIN1 had a substantial tendency for regression. Similarly, women with CIN2 had a higher probability of regression to normal/CIN1 than progression to CIN3(+). Findings in this study may have significant implications for the development and evaluation of formal cervical cancer preventive strategies in China. This study may serve as a valuable reference to future research on other multistate cancer processes. ©2014 American Association for Cancer Research.

  9. THE CHALLENGES OF INSTITUTIONALIZATION AND IMPLEMENTATION OF HISTORY-CRITICAL PEDAGOGY IN EARLY YEARS OF BASIC EDUCATION ITAIPULÂNDIA-PR

    Directory of Open Access Journals (Sweden)

    Celso Sidinei Balzan

    2013-12-01

    Full Text Available This paper is situated within the history of education and its purpose is to investigate the challenges of institutionalization of historical-critical pedagogy (PHC at the early elementary school years in municipal network Itaipulândia-PR. In it, we try to analyze briefly articulated with the proposals and actions carried out over several years, especially in 2010 itaipulandiense educational trajectory. These achievements currently make up the municipal public education policy that includes training programs that articulate with better working conditions, teaching and learning. Based on documents and literature review, discuss and seek to understand how the teachers of this county propositions developed from the study of the major challenges that the historical-critical pedagogy faces in Brazilian education, using experiences, educational programs and projects of State Governments and federal. In addressing the specific conditions that focus on education, the school and the organization of the teaching work through the analysis of its historical and educational history, we intend to analyze the process of institutionalization and implementation of this pedagogical trend in the early years of basic education in the municipality of Itaipulândia.

  10. The History of Neurosurgery at the National Hospital, Queen Square, London, with Some Personal Recollections from 1948 Onwards: The Early Years.

    Science.gov (United States)

    Powell, Michael P

    2017-07-01

    The National Hospital, Queen Square, London was founded as a charitable institution in 1860, becoming the first dedicated neuroscience hospital in the world. Sir Victor Horsley, the first neurosurgeon was appointed in 1886, and since that time, Queen Square neurosurgeons have been prominent on the World neurosurgical stage, including Sir Wylie McKissock and Prof Lindsay Symon, inter alia. This article gives the history taken from both published records and personal stories, recorded by a neurosurgeon who has worked at the hospital for thirty five years. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Treatment history and outcome of 24 deliveries worldwide after autotransplantation of cryopreserved ovarian tissue, including two new Danish deliveries years after autotransplantation

    DEFF Research Database (Denmark)

    Macklon, Kirsten T; Jensen, Annette Klüver; Loft, Anne

    2014-01-01

    PURPOSE: To report another two successful pregnancies and deliveries resulting from autotransplanted cryopreserved ovarian tissue several years after the autotransplantation procedure took place. Further, to review the literature on the treatment history, number of live births and their outcome so......'s lymphoma. Both suffered from premature ovarian insufficiency after treatment. Because of a pregnancy wish they later had pieces of thawed cortical tissue transplanted to the remaining ovary and the anterior abdominal wall. PubMed was searched for reports of deliveries resulting from cryopreserved ovarian...

  12. Preparing for Adulthood: Thousands Upon Thousands of New Cells are Born in the Hippocampus During Puberty and Most Survive with Effortful Learning

    Directory of Open Access Journals (Sweden)

    Daniel Martin Curlik, II

    2014-04-01

    Full Text Available The dentate gyrus of the hippocampal formation generates new granule neurons throughout life. The number of neurons produced each day is inversely related to age, with thousands more produced during puberty than during adulthood, and many fewer produced during senescence. In adulthood, approximately half of these cells undergo apoptosis shortly after they are generated. Most of these cells can be rescued from death by effortful and successful learning experiences (Gould et al., 1999; Waddell and Shors, 2008; Curlik and Shors, 2010. Once rescued, the newly-generated cells differentiate into neurons, and remain in the hippocampus for at least several months (Leuner et al., 2004. Here, we report that many new hippocampal cells also undergo cell death during puberty. Because the juvenile brain is more plastic than during adulthood, and because many experiences are new, we hypothesized that a great number of cells would be rescued by learning during puberty. Indeed, adolescent rats that successfully acquired the trace eyeblink response retained thousands more cells than animals that were not trained, and those that failed to learn. Because the hippocampus generates thousands more cells during puberty than during adulthood, these results support the idea that the adolescent brain is especially responsive to learning. This enhanced response can have significant consequences for the functional integrity of the hippocampus. Such a massive increase in cell proliferation is likely an adaptive response as the young animal must emerge from the care of its mother to face the dangers, challenges, and opportunities of adulthood.

  13. 100 years from the invention of X-rays. From the history of the radiology in Slovakia

    International Nuclear Information System (INIS)

    Kutarna, A.

    1996-01-01

    The survey of the development of radiology after the First World War (after disintegration of Austro-Hungarian Monarchy) as well as after the Second World War in Slovakia is given. Attention is dedicated to the development of radiodiagnostic and radiotherapeutic methods in Slovakia, as well as to personal occupation of the heads of radiologic clinics. In the last decade radiologic working-places and the departments are equipped with modern and efficient techniques. While in the year 1962 a number of the radiologists was about 90 doctors, in the year 1995 a number more than 360 doctors was registered from which are 80 doctors of radiotherapy. A number of radiologic assistants is about 1200. In Slovak hospitals are about 370 departments of radiology and more than 300 radiodiagnostic working-places and 12 departments of radiotherapy. 29 refs

  14. The Russian Orthodox and Catholic Church in 1980 – the 1990th Years: to History of Relationship

    Directory of Open Access Journals (Sweden)

    Larisa A. Koroleva

    2014-06-01

    Full Text Available In article relationship of Russian Orthodox Church and Catholic in 1980 – the 1990th years is considered. Dialogue development between them had not only internal political, but also foreign policy value. One of the most painful questions in relationship of Russian Orthodox Church and the question of the uniatsky church earlier existing in the territory of Ukraine and Belarus and restored in the second half of the 1980th years was Catholic. Divergences in a number of theological questions remained. In particular, it belonged to the doctrine confirmed with the Second Vatican Cathedral about Papal infallibility and a primacy of the Roman High priest. Peacekeeping activity was that sphere where the Russian Orthodox and Catholic churches most successfully cooperated though rivalry was present and here.

  15. Genomic analysis of 6,000-year-old cultivated grain illuminates the domestication history of barley.

    Science.gov (United States)

    Mascher, Martin; Schuenemann, Verena J; Davidovich, Uri; Marom, Nimrod; Himmelbach, Axel; Hübner, Sariel; Korol, Abraham; David, Michal; Reiter, Ella; Riehl, Simone; Schreiber, Mona; Vohr, Samuel H; Green, Richard E; Dawson, Ian K; Russell, Joanne; Kilian, Benjamin; Muehlbauer, Gary J; Waugh, Robbie; Fahima, Tzion; Krause, Johannes; Weiss, Ehud; Stein, Nils

    2016-09-01

    The cereal grass barley was domesticated about 10,000 years before the present in the Fertile Crescent and became a founder crop of Neolithic agriculture. Here we report the genome sequences of five 6,000-year-old barley grains excavated at a cave in the Judean Desert close to the Dead Sea. Comparison to whole-exome sequence data from a diversity panel of present-day barley accessions showed the close affinity of ancient samples to extant landraces from the Southern Levant and Egypt, consistent with a proposed origin of domesticated barley in the Upper Jordan Valley. Our findings suggest that barley landraces grown in present-day Israel have not experienced major lineage turnover over the past six millennia, although there is evidence for gene flow between cultivated and sympatric wild populations. We demonstrate the usefulness of ancient genomes from desiccated archaeobotanical remains in informing research into the origin, early domestication and subsequent migration of crop species.

  16. Human radiation studies: Remembering the early years. Oral history of biophysicist Robert Edmund Rowland, Ph.D., January 27, 1995

    International Nuclear Information System (INIS)

    1995-06-01

    This report provides a transcript of an oral interview with Dr. Robert Edmund Rowland by representatives of the US DOE Office of Human Radiation Research on January 27, 1995. Dr. Rowland was involved with the study of radium in the human body since 1950 and relates his knowledge of over 40 years of study of radium in the human body including dial painters, inmates of Elgin State Hospital, and other treated therapeutically with radium

  17. The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history.

    Science.gov (United States)

    Saunders, Norman R; Dreifuss, Jean-Jacques; Dziegielewska, Katarzyna M; Johansson, Pia A; Habgood, Mark D; Møllgård, Kjeld; Bauer, Hans-Christian

    2014-01-01

    Careful examination of relevant literature shows that many of the most cherished concepts of the blood-brain barrier are incorrect. These include an almost mythological belief in its immaturity that is unfortunately often equated with absence or at least leakiness in the embryo and fetus. The original concept of a blood-brain barrier is often attributed to Ehrlich; however, he did not accept that permeability of cerebral vessels was different from other organs. Goldmann is often credited with the first experiments showing dye (trypan blue) exclusion from the brain when injected systemically, but not when injected directly into it. Rarely cited are earlier experiments of Bouffard and of Franke who showed methylene blue and trypan red stained all tissues except the brain. The term "blood-brain barrier" "Blut-Hirnschranke" is often attributed to Lewandowsky, but it does not appear in his papers. The first person to use this term seems to be Stern in the early 1920s. Studies in embryos by Stern and colleagues, Weed and Wislocki showed results similar to those in adult animals. These were well-conducted experiments made a century ago, thus the persistence of a belief in barrier immaturity is puzzling. As discussed in this review, evidence for this belief, is of poor experimental quality, often misinterpreted and often not properly cited. The functional state of blood-brain barrier mechanisms in the fetus is an important biological phenomenon with implications for normal brain development. It is also important for clinicians to have proper evidence on which to advise pregnant women who may need to take medications for serious medical conditions. Beliefs in immaturity of the blood-brain barrier have held the field back for decades. Their history illustrates the importance of taking account of all the evidence and assessing its quality, rather than selecting papers that supports a preconceived notion or intuitive belief. This review attempts to right the wrongs. Based on

  18. The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history

    Science.gov (United States)

    Saunders, Norman R.; Dreifuss, Jean-Jacques; Dziegielewska, Katarzyna M.; Johansson, Pia A.; Habgood, Mark D.; Møllgård, Kjeld; Bauer, Hans-Christian

    2014-01-01

    Careful examination of relevant literature shows that many of the most cherished concepts of the blood-brain barrier are incorrect. These include an almost mythological belief in its immaturity that is unfortunately often equated with absence or at least leakiness in the embryo and fetus. The original concept of a blood-brain barrier is often attributed to Ehrlich; however, he did not accept that permeability of cerebral vessels was different from other organs. Goldmann is often credited with the first experiments showing dye (trypan blue) exclusion from the brain when injected systemically, but not when injected directly into it. Rarely cited are earlier experiments of Bouffard and of Franke who showed methylene blue and trypan red stained all tissues except the brain. The term “blood-brain barrier” “Blut-Hirnschranke” is often attributed to Lewandowsky, but it does not appear in his papers. The first person to use this term seems to be Stern in the early 1920s. Studies in embryos by Stern and colleagues, Weed and Wislocki showed results similar to those in adult animals. These were well-conducted experiments made a century ago, thus the persistence of a belief in barrier immaturity is puzzling. As discussed in this review, evidence for this belief, is of poor experimental quality, often misinterpreted and often not properly cited. The functional state of blood-brain barrier mechanisms in the fetus is an important biological phenomenon with implications for normal brain development. It is also important for clinicians to have proper evidence on which to advise pregnant women who may need to take medications for serious medical conditions. Beliefs in immaturity of the blood-brain barrier have held the field back for decades. Their history illustrates the importance of taking account of all the evidence and assessing its quality, rather than selecting papers that supports a preconceived notion or intuitive belief. This review attempts to right the wrongs

  19. The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart.

    Science.gov (United States)

    Venter, Carina; Maslin, Kate; Patil, Veeresh; Kurukulaaratchy, Ramesh; Grundy, Jane; Glasbey, Gillian; Twiselton, Roger; Dean, Taraneh; Arshad, Syed Hasan

    2016-12-01

    The aim of this study was to explore the natural history of peanut allergy in childhood in two birth cohorts from the same geographical region in the South of England. The FAIR birth cohort was established on the Isle of Wight (UK) between 2001 and 2002 (n = 969). Children were followed up prospectively, skin prick tested (SPT) to peanut allergens at 1, 2, 3 and 10 years and food challenges performed. The Isle of Wight (IOW) birth cohort was established in 1989 (n = 1456). SPTs were performed at 1, 2, 4 and 10 years. Peanut allergy was based on positive SPT and a good clinical history. In the FAIR cohort, the prevalence of sensitization to peanut was 0.4%, 2.0%, 2.0% and 2.4% at 1, 2, 3 and 10 years, respectively. At 10 years of age, 12 of 828 (1.5%) children were diagnosed with peanut allergy. One child (8%) outgrew her peanut allergy between 3 and 10 years and two children (15%) presented with new onset peanut allergy. Over the first 10 years of life, 13 of 934 (1.4%) children were diagnosed with peanut allergy. In the IOW cohort, 6 of 1034 (0.58%) were diagnosed with peanut allergy at 10 years. We found no significant differences between the FAIR and the IOW birth cohort for any of the time points studied. Peanut allergy appears to be stable over the first 10 years of life in our cohorts. There was no significant difference in peanut sensitization or clinical peanut allergy between 1989 and 2001. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  20. An Analysis of the History of Taiwanese Character and Moral Education (1949-2014 and Its Implications for the 12-Year Basic Education

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    Chih-Hua Fang

    2015-12-01

    Full Text Available The purpose of this paper was to analyze the history of character and moral education (CME during the past 65 years in Taiwan to form a complete image of CME and provide suggestions for the formulation and implementation of the 12-Year Basic Education Curriculum Guidelines. Concretely, the researchers reviewed the documents and literature of CME and divided the history from 1949 to 2014 into three phases - the Martial Law Phase, the Post-Martial Law Phase, and the 9-Year Curriculum Phase. During the Martial Law Phase, although CME was taught as a stand-alone subject, it played a role in transmitting political ideology. During the Post-Martial Law Phase, the goal was to implement a student-centered curriculum, but the period was too short to achieve total transformation. During the 9-Year Curriculum Phase, CME was omitted from the Curriculum Guidelines and replaced by the ‘Character and Moral Education Improving Project’ proclaimed by the Ministry of Education. As a result, CME was passively infused into the curriculum during this phase. Finally, the researchers proposed several suggestions as follows: The centrality of CME should be emphasized in the National Curriculum Guidelines to correspond to the public’s expectations and current international trends. Concrete contents of CME should be actively incorporated into the Curriculum Guidelines of each learning area in order to ensure effective integration and applicable transformation. Also, CME should be fully implemented in the 12-Year Basic Education Plan and include values of social justice and multiple developmental strategies.

  1. OSL Dating and GPR Mapping of Palaeotsunami Inundation: A 4000-Year History of Indian Ocean Tsunamis as recorded in Sri Lanka

    Science.gov (United States)

    Premasiri, Ranjith; Styles, Peter; Shrira, Victor; Cassidy, Nigel; Schwenninger, Jean-Luc

    2015-12-01

    To evaluate and mitigate tsunami hazard, as long as possible records of inundations and dates of past events are needed. Coastal sediments deposited by tsunamis (tsunamites) can potentially provide this information. However, of the three key elements needed for reconstruction of palaeotsunamis (identification of sediments, dating and finding the inundation distance) the latter remains the most difficult. The existing methods for estimating the extent of a palaeotsunami inundation rely on extensive excavation, which is not always possible. Here, by analysing tsunamites from Sri Lanka identified using sedimentological and paleontological characteristics, we show that their internal dielectric properties differ significantly from surrounding sediments. The significant difference in the value of dielectric constant of the otherwise almost indistinguishable sediments is due to higher water content of tsunamites. The contrasts were found to be sharp and not to erode over thousands of years; they cause sizeable electromagnetic wave reflections from tsunamite sediments, which permit the use of ground-penetrating radar (GPR) to trace their extent and morphology. In this study of the 2004 Boxing Day Indian Ocean tsunami, we use GPR in two locations in Sri Lanka to trace four identified major palaeotsunami deposits for at least 400 m inland (investigation inland was constrained by inaccessible security zones). The subsurface extent of tsunamites (not available without extensive excavation) provides a good proxy for inundation. The deposits were dated using the established method of optically stimulated luminescence (OSL). This dating, partly corroborated by available historical records and independent studies, contributes to the global picture of tsunami hazard in the Indian Ocean. The proposed method of combined GPR/OSL-based reconstruction of palaeotsunami deposits enables estimates of inundation, recurrence and, therefore, tsunami hazard for any sandy coast with

  2. Danish Breast Cancer Cooperative Group--DBCG: History, organization, and status of scientific achievements at 30-year anniversary

    DEFF Research Database (Denmark)

    Blichert-Toft, M.; Christiansen, Peter; Mouridsen, H.T.

    2008-01-01

    treatment programmes including in situ lesions and primary invasive breast cancer. Probands are subdivided into risk groups based on a given risk pattern and allocated to various treatment programmes accordingly. The scientific initiatives are conducted in the form of register- and cohort analysis...... on a risk scale. The main achievements resulted in a reduction of relative risk of death amounting up to 20% and increased 5-year overall survival ascending from 60% to roughly 80%. This article is partly based on a Danish paper to be published in the Centenary Jubilee book of the Danish Surgical Society...

  3. Journal of Innovation in Health Informatics: building on the 20-year history of a BCS Health peer review journal

    Directory of Open Access Journals (Sweden)

    Simon de Lusignan

    2015-02-01

    Full Text Available After 20-years as Informatics in Primary Care the journal is renamed Journal of Innovation in Health Informatics. The title was carefully selected to reflect that:(1 informatics provides the opportunity to innovate rather than simply automates;(2 implementing informatics solutions often results in unintended consequences, and many implementations fail and benefits and innovations may go unrecognised;(3 health informatics is a boundary spanning discipline and is by its very nature likely to give rise to innovation.Informatics is an innovative science, and informaticians need to innovate across professional and discipline boundaries.

  4. Invited review: reproductive physiology in commercial and premium pig breeds – history of 30-year-long cooperation

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    J. Rátky

    2017-08-01

    Full Text Available Cooperation of the Hungarian Research Institute for Animal Breeding and Nutrition (ATK with the German Leibniz Institute for Farm Animal Biology (FBN goes back many decades. In 1988 the two departments of reproductive biology began a joint project concerning on ovulation investigation in Landrace pigs. This joint project laid the foundation for further joint projects and has existed for almost 30 years. Over the years, the main focus has always been on the events of the female reproductive tract in pigs, i.e., follicular growth, ovulation, transport of gametes in the oviduct, fertilization and early embryonic development. Nearly all studies were done under in vivo circumstances and using different clinical and endocrinological methods, enabling us to obtain more profound knowledge of the dynamics of reproductive processes. Even results considered to be basic scientific achievements were available for utilization in the daily practice of porcine reproductive management. Since the end of the 1990s, the common projects have been gradually shifted to the physiology of the Hungarian indigenous pig breed Mangalica. Research partners were convinced that modern utilization of indigenous pig breeds would open new doors for premium pork production. In addition to the Mangalica breed, this principal was broadened to non-European fatty-type native pig breeds as well and resulted in long-term, intercontinental scientific cooperation.

  5. Natural History of Parkinson's Disease in the Province of Segovia: Disability in a 20 Years Longitudinal Study.

    Science.gov (United States)

    Duarte, Jacinto; García Olmos, Luis Miguel; Mendoza, Amelia; Martínez Pueyo, Ángel; Clavería, Luis Erik

    2015-01-01

    Parkinson's disease mainly affects the elderly population causing a progressive functional disability with motor, psychic, and cognitive deterioration. This study was carried out to evaluate disability caused by Parkinson's disease by analyzing the median time to reach Hoehn and Yahr stage III and to investigate predictor variables based on a 20-year longitudinal follow-up study. We examined 273 patients with Parkinson's disease recruited between 1978 and 1998. We performed a survival analysis using the Kaplan-Meier method to determine the time to disability and we used a Cox regression model to adjust prognosis factors. The median time to reach Hoehn and Yahr stage III was 7.73 years (95% CI: 5.95-8.05). Independent predictors of disability were: age at onset, the hazard ratio (HR) = 1.10, 95% CI: 1.08-1.12; UPDRS II (activities of daily living) HR = 1.08, 95% CI: 1.03-1.14; and akinesia and rigidity at onset HR = 1.55, 95% CI: 1.07-2.24. Patients with Parkinson's disease evolve gradually toward disability, and prognostic factors of this evolution were identified. © 2015 S. Karger AG, Basel.

  6. Research on history of Chinese seismology

    Science.gov (United States)

    Feng, Rui; Wu, Yuxia

    2010-06-01

    The history of Chinese seismology can be traced back to four thousand years before and divided into four stages, i.e., primitive knowledge, worship of nature, perceptual knowledge and scientific research. The second stage ran in the whole Qin-Han dynasties, and the fourth stage began from Emperor Kangxi in Qing Dynasty and continued to the present. So far China has made four great contributions to seismological development of the world, i.e., the invention of Heng Zhang’s seismoscope, great amount of historical records of earthquakes of four thousand years, most abundant anomaly data before earthquakes, and successful practice of earthquake prediction in Haicheng. However, the seismological research in China at present is still on the junior and developing stage. Now we have been carrying on some recessively historical load in our mind such as the subconsciousness of absolute obedience, habit of phenomenological study as well as the methods of philosophical analysis without sincerity. For constructing a high-level Chinese culture in seismological research, we need to pay attention to combining the phenomenological research with experiment, observation and theory study. It is also suggested to take the appropriated measures matched with the present research level in seismology, as well as to promote coexisting and merging of multi-cultures.

  7. Increasing Incidence of Colorectal Cancer in Adolescents and Young Adults Aged 15-39 Years in Western Australia 1982-2007: Examination of Colonoscopy History.

    Science.gov (United States)

    Troeung, Lakkhina; Sodhi-Berry, Nita; Martini, Angelita; Malacova, Eva; Ee, Hooi; O'Leary, Peter; Lansdorp-Vogelaar, Iris; Preen, David B

    2017-01-01

    To examine trends in colorectal cancer (CRC) incidence and colonoscopy history in adolescents and young adults (AYAs) aged 15-39 years in Western Australia (WA) from 1982 to 2007. Descriptive cohort study using population-based linked hospital and cancer registry data. Five-year age-standardized and age-specific incidence rates of CRC were calculated for all AYAs and by sex. Temporal trends in CRC incidence were investigated using Joinpoint regression analysis. The annual percentage change (APC) in CRC incidence was calculated to identify significant time trends. Colonoscopy history relative to incident CRC diagnosis was examined and age and tumor grade at diagnosis compared for AYAs with and without pre-diagnosis colonoscopy. CRC-related mortality within 5 and 10 years of incident diagnosis were compared for AYAs with and without pre-diagnosis colonoscopy using mortality rate ratios (MRRs) derived from negative binomial regression. Age-standardized CRC incidence among AYAs significantly increased in WA between 1982 and 2007, APC = 3.0 (95% CI 0.7-5.5). Pre-diagnosis colonoscopy was uncommon among AYAs (6.0%, 33/483) and 71% of AYAs were diagnosed after index (first ever) colonoscopy. AYAs with pre-diagnosis colonoscopy were older at CRC diagnosis (mean 36.7 ± 0.7 years) compared to those with no prior colonoscopy (32.6 ± 0.2 years), p  < 0.001. At CRC diagnosis, a significantly greater proportion of AYAs with pre-diagnosis colonoscopy had well-differentiated tumors (21.2%) compared to those without (5.6%), p  = 0.001. CRC-related mortality was significantly lower for AYAs with pre-diagnosis colonoscopy compared to those without, for both 5-year [MRR = 0.44 (95% CI 0.27-0.75), p  = 0.045] and 10-year morality [MRR = 0.43 (95% CI 0.24-0.83), p  = 0.043]. CRC incidence among AYAs in WA has significantly increased over the 25-year study period. Pre-diagnosis colonoscopy is associated with lower tumor grade at CRC diagnosis

  8. Increasing Incidence of Colorectal Cancer in Adolescents and Young Adults Aged 15–39 Years in Western Australia 1982–2007: Examination of Colonoscopy History

    Directory of Open Access Journals (Sweden)

    Lakkhina Troeung

    2017-07-01

    Full Text Available AimsTo examine trends in colorectal cancer (CRC incidence and colonoscopy history in adolescents and young adults (AYAs aged 15–39 years in Western Australia (WA from 1982 to 2007.DesignDescriptive cohort study using population-based linked hospital and cancer registry data.MethodFive-year age-standardized and age-specific incidence rates of CRC were calculated for all AYAs and by sex. Temporal trends in CRC incidence were investigated using Joinpoint regression analysis. The annual percentage change (APC in CRC incidence was calculated to identify significant time trends. Colonoscopy history relative to incident CRC diagnosis was examined and age and tumor grade at diagnosis compared for AYAs with and without pre-diagnosis colonoscopy. CRC-related mortality within 5 and 10 years of incident diagnosis were compared for AYAs with and without pre-diagnosis colonoscopy using mortality rate ratios (MRRs derived from negative binomial regression.ResultsAge-standardized CRC incidence among AYAs significantly increased in WA between 1982 and 2007, APC = 3.0 (95% CI 0.7–5.5. Pre-diagnosis colonoscopy was uncommon among AYAs (6.0%, 33/483 and 71% of AYAs were diagnosed after index (first ever colonoscopy. AYAs with pre-diagnosis colonoscopy were older at CRC diagnosis (mean 36.7 ± 0.7 years compared to those with no prior colonoscopy (32.6 ± 0.2 years, p < 0.001. At CRC diagnosis, a significantly greater proportion of AYAs with pre-diagnosis colonoscopy had well-differentiated tumors (21.2% compared to those without (5.6%, p = 0.001. CRC-related mortality was significantly lower for AYAs with pre-diagnosis colonoscopy compared to those without, for both 5-year [MRR = 0.44 (95% CI 0.27–0.75, p = 0.045] and 10-year morality [MRR = 0.43 (95% CI 0.24–0.83, p = 0.043].ConclusionCRC incidence among AYAs in WA has significantly increased over the 25-year study period. Pre-diagnosis colonoscopy is associated

  9. One thousand thermal cycles of magnesium chloride hexahydrate as a promising PCM for indoor solar cooking

    International Nuclear Information System (INIS)

    El-Sebaii, A.A.; Al-Heniti, S.; Al-Agel, F.; Al-Ghamdi, A.A.; Al-Marzouki, F.

    2011-01-01

    Research highlights: → Solar cookers must contain a PCM for cooking indoors. → MgCl 2 .6H 2 O when it cycled in a sealed container. → MgCl 2 .6H 2 O shows maximum of 0.1-3.5 o C of supercooling. → MgCl 2 .6H 2 O is a promising PCM for thermal energy storage. -- Abstract: Cooking is the major necessity for people all over the world. It accounts for a major share of energy consumption in developing countries. There is a critical need for the development of alternative, appropriate, affordable methods of cooking for use in developing countries. There is a history for solar cooking since 1650 where they are broadly divided into direct or focusing type, box-type and indirect or advanced solar cookers. The advanced solar cookers have the advantage of being usable indoors and thus solve one of the problems, which impede the social acceptance of solar cookers. The advanced type solar cookers are employing additional solar units that increase the cost. Therefore, the solar cooker must contain a heat storage medium to store thermal energy for use during off-sunshine hours. The main aim of this paper is to investigate the influence of the melting/solidification fast thermal cycling of commercial grade magnesium chloride hexahydrate (MgCl 2 .6H 2 O) on its thermo-physical properties; such as melting point and latent heat of fusion, to be used as a storage medium inside solar cookers. One thousand cycles have been performed in a sealed container under the extra water principle. The thermo-physical properties are measured using the differential scanning calorimetric technique. It is indicated that MgCl 2 .6H 2 O with the extra water principle and hermetically sealing of the container is a promising phase change material (PCM) for cooking indoors and during law intensity solar radiation periods. It is also found from the melting/solidification behavior of MgCl 2 .6H 2 O that it is solidify almost without supercooling; except in few cases where it showed maximum of 0

  10. A 58-Year-Old Woman with Left-Sided Weakness and a History of a Pediatric Brain Tumor: A Case Report

    Directory of Open Access Journals (Sweden)

    Shaakir Hasan

    2018-03-01

    Full Text Available Background: An uncommon but well-established complication of cranial irradiation is secondary neoplasm. This case presentation documents a radiation-induced malignant glioma 55 years after being diagnosed with “cerebral sarcoma,” now defined as atypical meningioma. This not only represents the longest reported latency period for a patient initially receiving over 30 Gy, but also provides a valuable historical perspective of neuro-oncology. Clinical Presentation: A 58-year-old female presenting with progressive left-sided upper and lower extremity weakness with a past medical history significant for “cerebral sarcoma” was diagnosed with glioblastoma multiforme. This patient had previously been treated with resection and adjuvant radiation therapy via a 280-kVP orthovoltage machine and received 3,390 rad to the posterior three-quarters of the skull for “cerebral sarcoma.” Conclusion: A comprehensive investigation of the past medical history helped uncover a mysterious pediatric diagnosis, helped drive the management 5 decades later, and serves as a reminder that seemingly safe interventions may still cause harm.

  11. Clinical and diagnosis characteristics of breast cancers in women with a history of radiotherapy in the first 30years of life: A French multicentre cohort study.

    Science.gov (United States)

    Demoor-Goldschmidt, C; Supiot, S; Oberlin, O; Helfre, S; Vigneron, C; Brillaud-Meflah, V; Bernier, V; Laprie, A; Ducassou, A; Claude, L; Mahé, M A; de Vathaire, F

    2017-08-01

    Irradiation (>3Gy) to the breast or axillae before 30years of age increases the risk of secondary breast cancer (SBC). The purpose of this article is to describe the clinical characteristics of SBC and the way of diagnosis in young women (before the age of national screening) in France who had received previous radiotherapy for a childhood or a young adulthood cancer. This retrospective, multicentre study reviewed the medical records of women with SBC before the age of the national screening who had received irradiation (≥3Gy) on part or all of the breast before 30years of age, for any type of tumour except BC. A total of 121 SBC were detected in 104 women with previous radiotherapy. Twenty percent of SBC were detected during regular breast screening and 16% of the women had a regular radiological follow-up. Our results points out that the main proportion of childhood cancer survivors did not benefit from the recommended breast cancer screening. This result is comparable to other previously published studies in other countries. A national screening programme is necessary and should take into account the patient's age, family history, personal medical history and previous radiotherapy to reduce the number of SBC diagnosed at an advanced stage. Copyright © 2017. Published by Elsevier B.V.

  12. Twenty years history and the future of Asian-Pacific Association of Laser Medicine and Surgery (APLMS)

    Science.gov (United States)

    Atsumi, Kazuhiko

    2005-07-01

    In 1986, APLMS was established to promote the various activities of Laser Medicine Surgery in the Asia-pacific regions. The purpose of APLMS is not only to deliver academic information but also technological, industrial and social ones. Until now, the 9 congresses had been taken place in the different countries in Asia-Pacific regions. As the results of the 18years" efforts, the organizations of each country on laser medicine and surgery have been established, and the network of researchers and clinicians has been completed. The next challenges are proposed such as education, training, and standardization of methods. To establish guidelines and regulation for laser medicine and surgery, and to transfer technology are also important issues.

  13. Association Between History of Multiple Concussions and Health Outcomes Among Former College Football Players: 15-Year Follow-up From the NCAA Concussion Study (1999-2001).

    Science.gov (United States)

    Kerr, Zachary Y; Thomas, Leah C; Simon, Janet E; McCrea, Michael; Guskiewicz, Kevin M

    2018-04-01

    Previous research has examined associations between concussion history and adverse health outcomes among former professional football players. Less is known about the potential effects of concussion among former college football players without additional exposure at the professional level. To examine the association between concussion and adverse health outcomes in a cohort of former college football players without exposure to professional football, 15 years after their playing careers ended. Cross-sectional study; Level of evidence, 3. A sample of 204 former collegiate football players (23.4% of eligible athletes with available contact information)-all of whom played at least 1 season of football from 1999 to 2001 in the National Collegiate Athletic Association (NCAA) and had no professional football exposure-completed a general health survey that assessed lifetime concussion history and included the following: the Veterans RAND 36 Item Health Survey, containing a physical composite score (PCS) and mental composite score (MCS); the depression module of the Patient Health Questionnaire; and the 4-item CAGE alcohol dependence questionnaire (for "cutting down, annoyance by criticism, guilty feeling, and eye-openers"). Multivariable binomial regression models estimated adjusted prevalence ratios (PRs) with 95% CIs while controlling for demographics and playing history covariates through forward selection model building. Most participants reported a concussion history (84.3%). Overall, 22.1% and 39.2% of participants reported a PCS and an MCS concussions (PR, 2.5; 95% CI, 1.3-4.9). Controlling for body mass index (BMI), the prevalence of moderate/severe depression was higher among those reporting ≥3 versus 0 concussions (PR, 4.2; 95% CI, 1.0-16.3). Controlling for BMI, the prevalence of having a PCS concussions (PR, 2.6; 95% CI, 1.3-5.0) but not 0 concussions (PR, 1.5; 95% CI, 0.6-3.6). No associations were found for alcohol dependence. Associations between a

  14. Archaeological Discoveries in the People’s Republic of China and Their Contribution to the Understanding of Chinese History

    Directory of Open Access Journals (Sweden)

    Xingcan Chen

    2009-11-01

    Full Text Available More than eight decades ago, the distinguished Chinese scholar Hu Shi (1891–1962 wrote an essay titled ‘My Views on Ancient History’, in which he said: My outlook regarding ancient history is, for the present, we should shorten the study of ancient history by two or three thousand years, and start our researches from the Book of Odes. When archaeology has become well developed, then we can slowly extend [our understanding of ancient history before the Eastern Zhou dynasty, using excavated historical evidence. Today, over eighty years later, Chinese history before the Eastern Zhou dynasty has been steadily reconstructed, step by step, from archaeological discoveries, without which, even the well-recognized deserved brilliance of ancient history, since the Eastern Zhou dynasty, would be dimmed.

  15. What Is the Natural History of "Asymptomatic" Pseudotumours in Metal-on-Metal Hip Arthroplasty? Minimum 4-Year Metal Artifact Reduction Sequence Magnetic Resonance Imaging Longitudinal Study.

    Science.gov (United States)

    Kwon, Young-Min; Liow, Ming Han Lincoln; Dimitriou, Dimitris; Tsai, Tsung-Yuan; Freiberg, Andrew A; Rubash, Harry E

    2016-09-01

    Metal Artifact Reduction Sequence Magnetic Resonance Imaging (MARS-MRI) is an important cross-sectional imaging modality in detection of metal-on-metal (MoM) hip arthroplasty (HA) pseudotumours. Potential evolution of pseudotumours detected by MARS-MRI in "asymptomatic" patients with MoMHA arthroplasty beyond 2 years remains largely unknown. The aims of this longitudinal study were to (1) determine the natural history of pseudotumours in "asymptomatic" MoMHA patients under MARS-MRI surveillance and (2) characterize MRI feature(s) associated with progressive pseudotumours. A total of 37 MoMHA (32 patients, mean 56 years old) with pseudotumours on MARS-MRI were evaluated longitudinally using a standardized MARS-MRI protocol. Serum cobalt and chromium levels, pseudotumour size, thickness of the cyst wall, and MRI signal intensity of the abnormality were recorded and analyzed. At minimum of 4-year follow-up (range 49-54 months), 4 Type II pseudotumours (11%) demonstrated MRI evidence of progression. Five Type I pseudotumours (14%) were found to have "regressed." No measurable MRI progression was detected in remaining patients (75%). MRI features associated with progressive pseudotumours included the presence of increased cystic wall thickness and "atypical" mixed fluid signal. MRI pseudotumour progression was not associated with metal ion levels. The natural history of type I cystic pseudotumours continues to be nonprogressive in most "asymptomatic" MoMHA patients at minimum 4 years, suggesting the importance of patient symptoms and MRI characteristic features in the clinical decision-making process. Routine follow-up MARS-MRI evaluation of "asymptomatic" patients with low-grade cystic pseudotumours in the absence of interval clinical changes may not be indicated. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Natural history of peanut allergy and predictors of resolution in the first 4 years of life: A population-based assessment.

    Science.gov (United States)

    Peters, Rachel L; Allen, Katrina J; Dharmage, Shyamali C; Koplin, Jennifer J; Dang, Thanh; Tilbrook, Kate P; Lowe, Adrian; Tang, Mimi L K; Gurrin, Lyle C

    2015-05-01

    There are no prospectively collected data available on the natural history of peanut allergy in early childhood. Previous studies of predictors of tolerance development have been biased by failure to challenge high-risk children when IgE antibody levels are high, therefore potentially introducing bias to persistent allergy. We sought to describe the natural history of peanut allergy between 1 and 4 years of age and develop thresholds for skin prick test (SPT) results and specific IgE (sIgE) levels measured at age 1 and 4 years that have 95% positive predictive value (PPV) or negative predictive value for the persistence or resolution of peanut allergy. One-year-old infants with challenge-confirmed peanut allergy (n = 156) from the population-based, longitudinal HealthNuts Study (n = 5276) were followed up at 4 years of age with repeat oral food challenges, SPTs, and sIgE measurements (n = 103). Challenges were undertaken in all peanut-sensitized children at 1 and 4 years of age, irrespective of risk profile. Peanut allergy resolved in 22% (95% CI, 14% to 31%) of children by age 4 years. Decreasing wheal size predicted tolerance, and increasing wheal size was associated with persistence. Thresholds for SPT responses and sIgE levels at age 1 year with a 95% PPV for persistent peanut allergy are an SPT-induced response of 13 mm or greater and an sIgE level of 5.0 kU/L or greater. Thresholds for SPT and sIgE results at age 4 years with a 95% PPV for persistent peanut allergy are an SPT response of 8 mm or greater and an sIgE level of 2.1 kU/L or greater. Ara h 2, tree nut, and house dust mite sensitization; coexisting food allergies; eczema; and asthma were not predictive of persistent peanut allergy. These thresholds are the first to be generated from a unique data set in which all participants underwent oral food challenges at both diagnosis and follow-up, irrespective of SPT and sIgE results. Copyright © 2015 American Academy of Allergy, Asthma & Immunology

  17. Detailed history of atmospheric trace elements from the Quelccaya ice core (Southern Peru) during the last 1200 years

    Science.gov (United States)

    Uglietti, C.; Gabrielli, P.; Thompson, L. G.

    2013-12-01

    The recent increase in trace element concentrations, for example Cr, Cu, Zn, Ag, Pb, Bi, and U, in polar snow and ice has provided compelling evidence of a hemispheric change in atmospheric composition since the nineteenth century. This change has been concomitant with the expansion of the Industrial Revolution and points towards an anthropogenic source of trace elements in the atmosphere. There are very few low latitude trace element ice core records and these are believed to be sensitive to perturbations of regional significance. To date, these records have not been used to document a preindustrial anthropogenic impact on atmospheric composition at low latitudes. Ice cores retrieved from the tropical Andes are particularly interesting because they have the potential to reveal detailed information about the evolution and environmental consequences of mineral exploitation related to the Pre Inca Civilizations, the Inca Empire (1438-1533 AD) and the subsequent Spanish invasion and dominance (1532-1833 AD). The chemical record preserved in the ice of the Quelccaya ice cap (southern Peruvian Andes) offers the exceptional opportunity to geochemically constrain the composition of the tropical atmosphere at high resolution over the last ~1200 years. Quantification of twenty trace elements (Ag, Al, As, Bi, Cd, Co, Cr, Cu, Fe, Mn, Mo, Pb, Rb, Sb, Sn, Ti, Tl, U, V, and Zn) was performed by ICP-SFMS over 105 m of the Quelccaya North Dome core (5600 m asl, 128.57 m) by analyzing 2450 samples. This provides the first atmospheric trace element record in South America spanning continuously and at high resolution for the time period between 1990 and 790 AD. Ag, As, Bi, Cd, Cr, Co, Cu, Mn, Mo, Sb, Sn, Pb and Zn show increases in concentration and crustal enrichment factor starting at different times between 1450 and 1550 AD, in concomitance with the expansions of the Inca Empire and, subsequently, the Spanish Empire well before the inception of the Industrial Revolution. This

  18. Coral Bleaching Susceptibility Is Decreased following Short-Term (1–3 Year Prior Temperature Exposure and Evolutionary History

    Directory of Open Access Journals (Sweden)

    Joshua A. Haslun

    2011-01-01

    Full Text Available Coral exposed to short periods of temperature stress (≥1.0°C above mean monthly maximum and/or increased frequencies of high temperatures may bolster resilience to global warming associated with climate change. We compared Montastraea cavernosa (Linnaeus, 1767; Cnidaria, Scleractinia, Faviidae from the Florida Keys National Marine Sanctuary (FKNMS and the Flower Garden Banks National Marine Sanctuary (FGBNMS. Thermal stress has been reported frequently within the FKNMS; however, corals in the FGBNMS experience nominal exposures to similar stressors. Corals were exposed to three temperatures (27°C, 31°C, and 35°C for 72 h. Colonies from the FKNMS lost significantly fewer viable and necrotic zooxanthellae under conditions of acute stress (35°C than the FGBNMS colonies. This indicates that the FKNMS corals are less temperature-sensitive than those in the FGBNMS. The observed differences point to greater prior temperature exposure and adaptation in the former versus the latter site when correlated to previous years of thermal exposure.

  19. Limiting bacterial contamination of enteral nutrient solutions: 6-year history with reduction of contamination at two institutions.

    Science.gov (United States)

    Fagerman, K E

    1992-02-01

    Running enteral nutrient solution (ENS) bacterial contamination logs that were collected over a 6-year time frame are presented. At hospital A, reconstituted ENS were prepared by the pharmacy department in bulk and were frozen in the final container. These solutions were cultured and counted after 12 hours of storage at room temperature to stimulate this institution's hang time. Major reductions in ENS bacterial counts occurred after improvements in sanitation, a reduction in solution hang time, the conversion to the use of sterile water for dilution and reconstitution of ENS, and most dramatically, after the incorporation of a preservative (potassium sorbate) to reconstituted ENS. At hospital B, ENS usage consisted of canned feedings that were prepared by nursing personnel and were transferred to the feeding container at the bedside. Reductions in final counts of contamination of ENS occurred after procedural changes, which included container changes every 24 hours, use of sterile water for dilution, cleansing of can lids with alcohol swabs before use, rinsing and air drying of intermittent feeding containers between feedings, and limiting feeding container fills to 4-hour hang time quantities. At both institutions, the value of an ongoing three-class enteral quality control program with a defined acceptance/rejection criteria was demonstrated in that ENS contamination was reduced to acceptable levels comparable with federal standards for milk and dairy products.

  20. The past 5000 years history of solar modulation of cosmic radiation from 10Be and 14C studies

    International Nuclear Information System (INIS)

    Oeschger, H.

    1990-01-01

    10 Be is produced in a similar way as 14 C by the interaction of cosmic radiation with the nuclei in the atmosphere. Assuming that the 10 Be and 14 C variation are proportional and considering the different behaviour in the Earth system, the 10 Be concentrations in ice cores can be compared with the 14 C variations in tree rings. A high correlation is found for the short-term variations ( 14 C-Suess-wiggles). They reflect with a high probability production rate variations. More problematic is the interpretation of the long-term trends of 14 C and 10 Be. Several explanations are discussed. The reconstructed CO 2 concentrations in ice cores indicate a rather constant value (280±10 p.p.m. by volume) during the past few millenia. Measurements on the ice core from Byrd Station, Antarctica, during the period 9000 to 6000 year BP indicate a decrease that might be explained by the extraction of CO 2 from the atmosphere-ocean system to build the terrestrial biomass pool during the climatic optimum. (author)

  1. The Changing Role of the Hawaiian Volcano Observatory within the Volcanological Community through its 100 year history

    Science.gov (United States)

    Kauahikaua, J. P.; Poland, M. P.

    2011-12-01

    When Thomas Jaggar, Jr., founded the Hawaiian Volcano Observatory in 1912, he wanted to "keep and publish careful records, invite the whole world of science to co-operate, and interest the business man." After studying the disastrous volcanic eruption at Martinique and Naples and the destructive earthquakes at Messina and the Caribbean Ocean, he saw observatories with these goals as a way to understand and mitigate these hazards. Owing to frequent eruptions, ease of access, and continuous record of activity (since January 17, 1912), Kilauea Volcano has been the focus for volcanological study by government, academic, and international investigators. New volcano monitoring techniques have been developed and tested on Hawaiian volcanoes and exported worldwide. HVO has served as a training ground for several generations of volcanologists; many have contributed to volcano research and hazards mitigation around the world. In the coming years, HVO and the scientific community will benefit from recent upgrades in our monitoring network. HVO had the first regional seismic network in the US and it will be fully digital; continuous GPS, tilt, gravity, and strain data already complement the seismic data; an array of infrared and visual cameras simultaneously track geologic surface changes. Scientifically, HVO scientists and their colleagues are making great advances in understanding explosive basaltic eruptions, volcanic gas emission and dispersion and its hazards, and lava flow mechanics with these advanced instruments. Activity at Hawaiian volcanoes continues to provide unparalleled opportunities for research and education, made all the more valuable by HVO's scientific legacy.

  2. Natural history of snoring and other sleep-disordered breathing (SDB) symptoms in 7-year-old New Zealand children: a follow-up from age 3.

    Science.gov (United States)

    Luo, Rebekah; Schaughency, Elizabeth; Gill, Amelia I; Dawes, Patrick J D; Galland, Barbara C

    2015-09-01

    We aimed to examine the natural history of snoring and associated symptoms in a community sample of New Zealand children at ages 3 and 7 years, and identify factors associated with habitual snoring at age 7 years. Parent/s of children (n = 839) who completed the community survey about their child's sleep and breathing at age 3 years were re-contacted via mail 4 years later when children were aged 7 years. Parents were asked to complete a follow-up questionnaire which included items relating to their child's sleep and health, and family demographic information. There was a 54.8% (n = 460) response rate. At follow-up, habitual snoring was prevalent in 9.2% of the sample, similar to the 11.3% reported at age 3 years. However, habitual snoring status changed over time; 36.2% (n = 21/58) remained habitual snorers; 63.8% (n = 37/58) were no longer snoring habitually, while 5.3% (n = 21/397) had started habitual snoring since the initial survey. Overall, the reported severity of SDB-related symptoms decreased over time, regardless of initial habitual snoring status. Nonetheless, habitual snoring at follow-up was significantly associated with mouth breathing, sleeping with the neck extended, sweating profusely, night waking, and parent-reported child irritability. Our findings highlight the dynamic nature of SDB, where habitual snoring and related symptoms can develop, remain present, or resolve at different times, over early-mid-childhood years. Given the dynamic nature of habitual snoring over the early childhood years, pediatricians should continue to screen for snoring and sleep apnea on an annual basis throughout childhood.

  3. Sapiens a brief history of humankind

    CERN Document Server

    Harari, Yuval Noah

    2015-01-01

    From a renowned historian comes a groundbreaking narrative of humanity’s creation and evolution—a #1 international bestseller—that explores the ways in which biology and history have defined us and enhanced our understanding of what it means to be “human.” One hundred thousand years ago, at least six different species of humans inhabited Earth. Yet today there is only one—homo sapiens. What happened to the others? And what may happen to us? Most books about the history of humanity pursue either a historical or a biological approach, but Dr. Yuval Noah Harari breaks the mold with this highly original book that begins about 70,000 years ago with the appearance of modern cognition. From examining the role evolving humans have played in the global ecosystem to charting the rise of empires, Sapiens integrates history and science to reconsider accepted narratives, connect past developments with contemporary concerns, and examine specific events within the context of larger ideas. Dr. Harari also comp...

  4. Comparison of elemental carbon in lake sediments measured by three different methods and 150-year pollution history in Eastern China.

    Science.gov (United States)

    Han, Y M; Cao, J J; Yan, B Z; Kenna, T C; Jin, Z D; Cheng, Y; Chow, Judith C; An, Z S

    2011-06-15

    Concentrations of elemental carbon (EC) were measured in a 150 yr sediment record collected from Lake Chaohu in Anhui Province, eastern China, using three different thermal analytical methods: IMPROVE_A thermal optical reflectance (TOR), STN_thermal optical transmittance (TOT), and chemothermal oxidation (CTO). Distribution patterns for EC concentrations are different among the three methods, most likely due to the operational definition of EC and different temperature treatments prescribed for each method. However, similar profiles were found for high-temperature EC fractions among different methods. Historical soot(TOR) (high-temperature EC fractions measured by the IMPROVE_A TOR method) from Lake Chaohu exhibited stable low concentrations prior to the late 1970s and a sharp increase thereafter, corresponding well with the rapid industrialization of China in the last three decades. This may suggest that high-temperature thermal protocols are suitable for differentiating between soot and other carbon fractions. A similar soot(TOR) record was also obtained from Lake Taihu (~200 km away), suggesting a regional source of soot. The ratio of char(TOR) (low-temperature EC fraction measured by the IMPROVE_A TOR method, after correction for pyrolysis) to soot(TOR) in Lake Chaohu shows an overall decreasing trend, consistent with gradual changes in fuel use from wood burning to increasing fossil fuel combustions. Average higher char(TOR)/soot(TOR) was observed in Lake Taihu than in Lake Chaohu in the past 150 years, consistent with the longer and more extensive industrialization around the Taihu region.

  5. Lifetime Smoking History and Cause-Specific Mortality in a Cohort Study with 43 Years of Follow-Up.

    Directory of Open Access Journals (Sweden)

    Niloofar Taghizadeh

    Full Text Available In general, smoking increases the risk of mortality. However, it is less clear how the relative risk varies by cause of death. The exact impact of changes in smoking habits throughout life on different mortality risks is less studied.We studied the impact of baseline and lifetime smoking habits, and duration of smoking on the risk of all-cause mortality, mortality of cardiovascular diseases (CVD, chronic obstructive pulmonary disease (COPD, any cancer and of the four most common types of cancer (lung, colorectal, prostate, and breast cancer in a cohort study (Vlagtwedde-Vlaardingen 1965-1990, with a follow-up on mortality status until 2009, n = 8,645. We used Cox regression models adjusted for age, BMI, sex, and place of residence. Since previous studies suggested a potential effect modification of sex, we additionally stratified by sex and tested for interactions. In addition, to determine which cause of death carried the highest risk we performed competing-risk analyses on mortality due to CVD, cancer, COPD and other causes.Current smoking (light, moderate, and heavy cigarette smoking and lifetime persistent smoking were associated with an increased risk of all-cause, CVD, COPD, any cancer, and lung cancer mortality. Higher numbers of pack years at baseline were associated with an increased risk of all-cause, CVD, COPD, any cancer, lung, colorectal, and prostate cancer mortality. Males who were lifetime persistent pipe/cigar smokers had a higher risk of lung cancer [HR (95% CI = 7.72 (1.72-34.75] as well as all-cause and any cancer mortality. A longer duration of smoking was associated with a higher risk of COPD, any and lung cancer [HR (95% CI = 1.06 (1.00-1.12, 1.03 (1.00-1.06 and 1.10 (1.03-1.17 respectively], but not with other mortality causes. The competing risk analyses showed that ex- and current smokers had a higher risk of cancer, CVD, and COPD mortality compared to all other mortality causes. In addition, heavy smokers had a higher

  6. Factors controlling the geochemical evolution of fumarolic encrustations, Valley of Ten Thousand Smokes, Alaska

    Science.gov (United States)

    Kodosky, L.G.; Keith, T.E.C.

    1993-01-01

    Factor and canonical correlation analysis of geochemical data from eight fossil fumaroles suggest that six major factors controlled the formation and evolution of fumarolic encrustations on the 1912 ash-flow sheet in the Valley of Ten Thousand Smokes (VTTS). The six-factor solution model explains a large proportion (low of 74% for Ni to high of 99% for Si) of the individual element data variance. Although the primary fumarolic deposits have been degraded by secondary alteration reactions and up to 75 years of weathering, the relict encrustations still preserve a signature of vapor-phase element transport. This vapor-phase transport probably occurred as halide or oxyhalide species and was significant for As, Sb and Br. At least three, and possibly four, varied temperature leaching events affected the fumarolic deposits. High-temperature gases/liquids heavily altered the ejecta glass and mineral phases adjacent to the fumarolic conduit. As the fumaroles cooled. Fe-rich acidic condensate leached the ejecta and primary fumarolic deposits and resulted in the subsequent precipitation of Fe-hydroxides and/or Fe-oxides. Low- to ambient-temperature leaching and hydration reactions generated abundant hydrated amorphous phases. Up to 87% of the individual element data variance is apparently controlled by the chemistry of the ejecta on which the relict encrustations are found. This matrix chemistry factor illustrates that the primary fumarolic minerals surrounding the active VTTS vents observed by earlier workers have been effectively removed by the dissolution reactions. Element enrichment factors calculated for the VTTS relict encrustations support the statistical factor interpretations. On the average, the relict encrustations are enriched, relative to visibly unaltered matrix protolith, in As, Br, Cr, Sb, Cu, Ni, Pb, Fe, and LOI (an indirect measure of sample H2O content). ?? 1993.

  7. Eusociality in history.

    Science.gov (United States)

    Betzig, Laura

    2014-03-01

    For more than 100,000 years, H. sapiens lived as foragers, in small family groups with low reproductive variance. A minority of men were able to father children by two or three women; and a majority of men and women were able to breed. But after the origin of farming around 10,000 years ago, reproductive variance increased. In civilizations which began in Mesopotamia, Egypt, India, and China, and then moved on to Greece and Rome, kings collected thousands of women, whose children were supported and guarded by thousands of eunuchs. Just a few hundred years ago, that trend reversed. Obligate sterility ended, and reproductive variance declined. For H. sapiens, as for other organisms, eusociality seems to be an effect of ecological constraints. Civilizations rose up in lake and river valleys, hemmed in by mountains and deserts. Egalitarianism became an option after empty habitats opened up.

  8. The Galex Time Domain Survey. I. Selection And Classification of Over a Thousand Ultraviolet Variable Sources

    Science.gov (United States)

    Gezari, S.; Martin, D. C.; Forster, K.; Neill, J. D.; Huber, M.; Heckman, T.; Bianchi, L.; Morrissey, P.; Neff, S. G.; Seibert, M.; hide

    2013-01-01

    We present the selection and classification of over a thousand ultraviolet (UV) variable sources discovered in approximately 40 deg(exp 2) of GALEX Time Domain Survey (TDS) NUV images observed with a cadence of 2 days and a baseline of observations of approximately 3 years. The GALEX TDS fields were designed to be in spatial and temporal coordination with the Pan-STARRS1 Medium Deep Survey, which provides deep optical imaging and simultaneous optical transient detections via image differencing. We characterize the GALEX photometric errors empirically as a function of mean magnitude, and select sources that vary at the 5 sigma level in at least one epoch. We measure the statistical properties of the UV variability, including the structure function on timescales of days and years. We report classifications for the GALEX TDS sample using a combination of optical host colors and morphology, UV light curve characteristics, and matches to archival X-ray, and spectroscopy catalogs. We classify 62% of the sources as active galaxies (358 quasars and 305 active galactic nuclei), and 10% as variable stars (including 37 RR Lyrae, 53 M dwarf flare stars, and 2 cataclysmic variables). We detect a large-amplitude tail in the UV variability distribution for M-dwarf flare stars and RR Lyrae, reaching up to absolute value(?m) = 4.6 mag and 2.9 mag, respectively. The mean amplitude of the structure function for quasars on year timescales is five times larger than observed at optical wavelengths. The remaining unclassified sources include UV-bright extragalactic transients, two of which have been spectroscopically confirmed to be a young core-collapse supernova and a flare from the tidal disruption of a star by dormant supermassive black hole. We calculate a surface density for variable sources in the UV with NUV less than 23 mag and absolute value(?m) greater than 0.2 mag of approximately 8.0, 7.7, and 1.8 deg(exp -2) for quasars, active galactic nuclei, and RR Lyrae stars

  9. Studying Ancient History.

    Science.gov (United States)

    Barrow, Robin

    1982-01-01

    Defends the value and relevance of the study of ancient history and classics in history curricula. The unique homogeneity of the classical period contributes to its instructional manageability. A year-long, secondary-level course on fifth-century Greece and Rome is described to illustrate effective approaches to teaching ancient history. (AM)

  10. Peat accretion histories during the past 6,000 years in marshes of the Sacramento-San Joaquin delta, CA, USA

    Science.gov (United States)

    Drexler, Judith Z.; de Fontaine, Christian S.; Brown, Thomas A.

    2009-01-01

    The purpose of this study was to determine how vertical accretion rates in marshes vary through the millennia. Peat cores were collected in remnant and drained marshes in the Sacramento-San Joaquin Delta of California. Cubic smooth spline regression models were used to construct age-depth models and accretion histories for three remnant marshes. Estimated vertical accretion rates at these sites range from 0.03 to 0.49 cm year-1. The mean contribution of organic matter to soil volume at the remnant marsh sites is generally stable (4.73% to 6.94%), whereas the mean contribution of inorganic matter to soil volume has greater temporal variability (1.40% to 7.92%). The hydrogeomorphic position of each marsh largely determines the inorganic content of peat. Currently, the remnant marshes are keeping pace with sea level rise, but this balance may shift for at least one of the sites under future sea level rise scenarios.

  11. Using Stochastically Downscaled Climate Models and Multiproxy Lake Sediment Data to Connect Climatic Variations Over the Past 1000 Years and the History of Prehistoric Maize Farming in Utah

    Science.gov (United States)

    Thomson, M. J.; MacDonald, G. M.

    2015-12-01

    We are investigating the relationship between climatic variations over the past 1000 years and the history of prehistoric maize farming expansion and decline in the American Southwest, with a focus on Utah. We are examining both the downscaled climate models and high resolution analyses of lake cores and dendrochronological data matched with occupation information. We are testing the specific utility of stochastically downscaled general circulation models (viz. ECHO-G) to reconstruct local conditions for sites with documented prehistoric dryland farming through the so-called Medieval Climate Anomaly (MCA) and transition to the Little Ice Age (LIA). We are testing our model-based reconstructions with proxies of temperature and aridity from three subalpine lake sediment cores transecting Utah. We compare the patterns of climate change from the downscaled models and the paleoclimate records to a database of 837 radiocarbon dates over 169 locations of archaeological Native American maize-farmer site occupations in Utah.

  12. Differences in various biochemical and clinical parameters with respect to family history of Non Communicable Diseases in fourth year MBBS students of Karachi, Pakistan

    Science.gov (United States)

    Basit, Khalid Abdul; Fawwad, Asher; Munir, Muhammad Asadullah; Siddiqui, Iftikhar Ahmed; Siddiqui, Sidra; Basit, Abdul

    2015-01-01

    Objective: To observe the differences of various biochemical and clinical parameters with respect to Family History (FH) of Non-communicable Diseases (NCDs) in fourth year Bachelor of Medicine, Bachelor of Surgery (MBBS) students. Methods: This observational study was conducted at Baqai Institute of Diabetology & Endocrinology from December 2013 to January 2014. Total 50 medical students from Dow University of Health Sciences (DUHS) participated in the study. Statistical Package for Social Sciences (SPSS) version 13 was used to analyze the data. For cross tabulation and mean comparison z-test and t test were applied. Results: Out of 50 subjects, there were 26 (52%) females. Mean age of the study population was 21.56 ± 0.90 years. Mean serum cholesterol levels with positive FH of NCDs was significantly higher than negative FH of NCDs (p=0.005). Mean value of low density lipoprotein (LDL) of positive family history of NCDs was found higher than those with negative FH (p=0.006) being statistically significant. The insulin levels in subjects with positive FH of NCDs were higher than subjects with negative FH of NCDs (p=0.685). However, serum leptin and plasma renin showed no significant difference with the negative FH of NCDs being higher compared to positive FH of NCDs (p=0.068) and (p=0.884) respectively. However, Waist circumference, Body mass index and central obesity in subjects with positive FH of NCDs shows increasing trend but no statistically significant difference (p > 0.05) was observed. Conclusion: In our study of various biochemical and clinical parameters with respect to FH of NCDs, Serum Cholesterol and LDL levels were observed higher and statistically significant. PMID:26430439

  13. Putting the Pieces Together: Using Jane Smiley's "A Thousand Acres" in Sociology of Families.

    Science.gov (United States)

    Hall, Kelley J.

    2000-01-01

    Addresses the use of fiction to teach undergraduate students about sociological theories and concepts. Discusses how "A Thousand Acres" (Jane Smiley) was used in a sociology of families course. Includes descriptions of the plot and themes in the book and the group work and paper assigned in conjunction with Smiley's novel. (CMK)

  14. Sadako and the Thousand Paper Cranes: The Dialogic Narrative in the Educational Act

    Science.gov (United States)

    Al-Jafar, Ali A.

    2016-01-01

    This study used the story of "Sadako and the thousand paper cranes" by Coerr (1977) to discover similarities between the events of August 1945 in Hiroshima and the events of August 1990 in Kuwait. The participants in a children's literature class at Kuwait University folded paper cranes and wrote in their journals to answer two…

  15. Outcome of dental implants in patients with and without a history of periodontitis: a 5-year pragmatic multicentre retrospective cohort study of 1727 patients.

    Science.gov (United States)

    Gianserra, Rodolfo; Cavalcanti, Raffaele; Oreglia, Francesco; Manfredonia, Massimo Francesco; Esposito, Marco

    2010-01-01

    To evaluate the outcome of dental implants placed in patients with a history of periodontitis. Patients with no or mild history of periodontitis served as controls. A total of 1727 patients were consecutively treated in four private practices. Patients were divided into three groups according to their initial periodontal conditions assessed with a modified periodontal screening and recording (PSR) index: 630 patients were in the severe periodontitis (SP) group, 839 in the moderate periodontitis (MP) group, and 258 had no periodontitis (NP). Patients requiring periodontal treatment were treated prior to implantation. Various implant systems and procedures were used. In total, 3260 implants and 1707 implant-supported prostheses were placed in the SP group, 2813 implants and 1744 implant-supported prostheses in the MP group, and 647 implants and 424 implant-supported prostheses in the NP group. Mixed implant–tooth supported prostheses (98 prostheses in 89 patients) were not considered. Outcome measures were prosthesis and implant survival. Two-hundred and fifty patients were lost to follow-up 5 years after loading. Regarding prosthesis failures, 13 prostheses could not be placed or failed in 13 patients of the SP group (0.8%), 11 prostheses could not be placed or failed in 9 patients of the MP group (0.7%), and 3 prostheses failed in 3 patients of the NP group (0.9%). For implant failures, 130 (4.5%) implants failed in the SP group, 74 (3.1%) implants failed in the MP group, and 15 (3.0%) implants failed in the NP group. Most of the implant failures (90%) occurred before implant loading. Fitting a logistic regression for early implant failures and total implant failures, taking into account the clustering of implants in patients, there were no statistically significant differences between the three PSR groups (P > 0.05). Owing to the retrospective nature of this study, conclusions need to be interpreted with caution. A previous history of periodontal disease may not

  16. Canadian petroleum history bibliography

    Energy Technology Data Exchange (ETDEWEB)

    Cass, D.

    2003-09-27

    The Petroleum History Bibliography includes a list of more than 2,000 publications that record the history of the Canadian petroleum industry. The list includes books, theses, films, audio tapes, published articles, company histories, biographies, autobiographies, fiction, poetry, humour, and an author index. It was created over a period of several years to help with projects at the Petroleum History Society. It is an ongoing piece of work, and as such, invites comments and additions.

  17. An 800-year fire history

    Science.gov (United States)

    Stanley G. Kitchen

    2010-01-01

    "Fire in the woods!" The words are a real heart stopper. Yet in spite of its capacity to destroy, fire plays an essential role in shaping plant communities. Knowledge of the patterns of fire over long time periods is critical for understanding this role. Trees often retain evidence of nonlethal fires in the form of injuries or scars in the annual growth rings...

  18. Analytic versus systemic group therapy for women with a history of child sexual abuse: 1-year follow-up of a randomized controlled trial.

    Science.gov (United States)

    Elkjaer, Henriette; Kristensen, Ellids; Mortensen, Erik L; Poulsen, Stig; Lau, Marianne

    2014-06-01

    This randomized prospective study examines durability of improvement in general symptomatology, psychosocial functioning and interpersonal problems, and compares the long-term efficacy of analytic and systemic group psychotherapy in women 1 year after completion of treatment for childhood sexual abuse. Women (n = 106) randomly assigned to analytic or systemic psychotherapy completed the Symptom Checklist-90-R, Global Assessment of Functioning, Global Life Quality, Registration Chart Questionnaire, and Flashback Registration at pre-treatment, post-treatment, and at a 1-year follow-up. Post-treatment gains were significant for both treatment modalities on all measures, but significantly larger after systemic therapy. Significant treatment response was maintained 1-year post-treatment, but different trajectories were observed: 1 year after treatment completion, improvements for analytic therapy were maintained, whereas they decreased after systemic therapy, resulting in no statistically significant difference in gains between the groups at the 1-year follow-up. Despite maintaining significant gains, more than half of the patients remained above cut-off for caseness concerning general symptomatology at post-treatment and at 1-year follow-up. The findings stress the importance of long-term follow-up data in effect studies. Different trajectories were associated with the two treatments, but improvement in the two treatment groups did not differ significantly at the 1-year follow-up. Implications of the difference in trajectories for treatment planning are discussed. Both analytic and systemic group therapy proved efficient in improving general symptomatology, psychosocial functioning, and interpersonal problems in women with a history of CSA and gains were maintained at a 1-year follow-up. Despite maintaining statistically significant gains at the 1-year follow-up, 54% of the patients remained above the cut-off for caseness with respect to general symptomatology, which

  19. Ongoing hydrothermal heat loss from the 1912 ash-flow sheet, Valley of Ten Thousand Smokes, Alaska

    Science.gov (United States)

    Hogeweg, N.; Keith, T.E.C.; Colvard, E.M.; Ingebritsen, S.E.

    2005-01-01

    The June 1912 eruption of Novarupta filled nearby glacial valleys on the Alaska Peninsula with ash-flow tuff (ignimbrite), and post-eruption observations of thousands of steaming fumaroles led to the name 'Valley of Ten Thousand Smokes' (VTTS). By the late 1980s most fumarolic activity had ceased, but the discovery of thermal springs in mid-valley in 1987 suggested continued cooling of the ash-flow sheet. Data collected at the mid-valley springs between 1987 and 2001 show a statistically significant correlation between maximum observed chloride (Cl) concentration and temperature. These data also show a statistically significant decline in the maximum Cl concentration. The observed variation in stream chemistry across the sheet strongly implies that most solutes, including Cl, originate within the area of the VTTS occupied by the 1912 deposits. Numerous measurements of Cl flux in the Ukak River just below the ash-flow sheet suggest an ongoing heat loss of ???250 MW. This represents one of the largest hydrothermal heat discharges in North America. Other hydrothermal discharges of comparable magnitude are related to heat obtained from silicic magma bodies at depth, and are quasi-steady on a multidecadal time scale. However, the VTTS hydrothermal flux is not obviously related to a magma body and is clearly declining. Available data provide reasonable boundary and initial conditions for simple transient modeling. Both an analytical, conduction-only model and a numerical model predict large rates of heat loss from the sheet 90 years after deposition.

  20. Assessment of visual perception in adolescents with a history of central coordination disorder in early life - 15-year follow-up study.

    Science.gov (United States)

    Kiebzak, Wojciech; Kowalski, Ireneusz M; Domagalska, Małgorzata; Szopa, Andrzej; Dwornik, Michał; Kujawa, Jolanta; Stępień, Agnieszka; Sliwiński, Zbigniew

    2012-11-09

    Central nervous system damage in early life results in both quantitative and qualitative abnormalities of psychomotor development. Late sequelae of these disturbances may include visual perception disorders which not only affect the ability to read and write but also generally influence the child's intellectual development. This study sought to determine whether a central coordination disorder (CCD) in early life treated according to Vojta's method with elements of the sensory integration (S-I) and neuro-developmental treatment (NDT)/Bobath approaches affects development of visual perception later in life. The study involved 44 participants aged 15-16 years, including 19 diagnosed with moderate or severe CCD in the neonatal period, i.e. during the first 2-3 months of life, with diagnosed mild degree neonatal encephalopathy due to perinatal anoxia, and 25 healthy people without a history of developmental psychomotor disturbances in the neonatal period. The study tool was a visual perception IQ test comprising 96 graphic tasks. The study revealed equal proportions of participants (p < 0.05) defined as very skilled (94-96), skilled (91-94), aerage (71-91), poor (67-71), and very poor (0-67) in both groups. These results mean that adolescents with a history of CCD in the neonatal period did not differ with regard to the level of visual perception from their peers who had not demonstrated psychomotor development disorders in the neonatal period. Early treatment of children with CCD affords a possibility of normalising their psychomotor development early enough to prevent consequences in the form of cognitive impairments in later life.

  1. Nutritional and metabolic programming during the first thousand days of life

    Directory of Open Access Journals (Sweden)

    Massimo Agosti

    2017-06-01

    Full Text Available The latest scientific acquisitions are demonstrating what has already been hypothesized for more than twenty years about the development of the state of health/illness of individuals. Indeed, certain stimuli, if applied to a sensible phase of development, are able to modify, through epigenetic mechanisms, gene expression of DNA, resulting in adaptive modifications of phenotype to the environment, which may reflect negatively on the health of every individual. This concept, applied to nutrition, has opened up important prospects for research in this area. The nutritional history of an individual, linked to the development of a healthy state, would begin very early. In fact, since the pregnancy and for the next two years (for a total of about 1000 days, the maternal eating habits, the type of breastfeeding and then the main stages of nutrition in the evolutionary phase represent those sensitive moments, essential for the development of important endocrine, metabolic, immunological alterations, better known as metabolic syndrome. This condition would represent the physiopathogenetic basis for explaining a series of disorders, known as non communicable diseases (NCDs such as obesity, diabetes, hypertension, cardiovascolar disease and all those conditions that today affect the health of most industrialized countries and through the years are emerging especially in developing countries (South America, Asia, where new environmental conditions and increased food availability are changing food habits, with far-reaching public health impacts. This paper analyzes these new nutritional perspectives and the main implications of what has been termed the 1000-day theory.

  2. The history of the tetracyclines.

    Science.gov (United States)

    Nelson, Mark L; Levy, Stuart B

    2011-12-01

    The history of the tetracyclines involves the collective contributions of thousands of dedicated researchers, scientists, clinicians, and business executives over the course of more than 60 years. Discovered as natural products from actinomycetes soil bacteria, the tetracyclines were first reported in the scientific literature in 1948. They were noted for their broad spectrum antibacterial activity and were commercialized with clinical success beginning in the late 1940s to the early 1950s. The second-generation semisynthetic analogs and more recent third-generation compounds show the continued evolution of the tetracycline scaffold toward derivatives with increased potency as well as efficacy against tetracycline-resistant bacteria, with improved pharmacokinetic and chemical properties. Their biologic activity against a wide spectrum of microbial pathogens and their uses in mammalian models of inflammation, neurodegeneration, and other biological systems indicate that the tetracyclines will continue to be successful therapeutics in infectious diseases and as potential therapeutics against inflammation-based mammalian cell diseases. © 2011 New York Academy of Sciences.

  3. A History of Court and Commoner Clothing in Vietnam

    Directory of Open Access Journals (Sweden)

    Liam C. Kelley

    2016-09-01

    Full Text Available Trần Quang Đức. Ngàn năm áo mũ: Lich sử trang phục Việt Nam giai đoạn 1009–1945 [One thousand years of caps and robes: A history of Vietnamese clothing in the period 1009–1945]. TP Hồ Chí Minh: Nhã Nam, 2013. ISBN: 1467557900. Đức documents in incredible detail the history of the sartorial decisions made at various Vietnamese courts, from Quyền’s time until the end of the Nguyễn dynasty. Based on an extensive examination of Vietnamese, Chinese, European, and even Korean sources—most of which only briefly mention clothing in various periods—Đức has succeeded in producing a comprehensive overview of the clothing of Vietnamese rulers and their officials; when possible, he also comments on the dress of other segments of society, such as the military and commoners. One Thousand Years of Caps and Robes devotes a chapter to each Vietnamese dynasty: the Lý, the Trần, the Lê, the Tây Sơn, and the Nguyễn. Đức begins each chapter with an overview of the history of that dynasty’s styles of court dress and then goes into a detailed description of exactly which types of cap and robe the ruler and his officials wore, and in what ways these caps and robes extended previous practices or were innovations. He follows his examination of court dress with a discussion of military and commoner attire. The chapter introductions provide a concise history of changes in court clothing across time, while the detailed discussions of the caps and robes from each period offer a deeper level of understanding...

  4. [Nested species subsets of amphibians and reptiles in Thousand Island Lake].

    Science.gov (United States)

    Wang, Xi; Wang, Yan-Ping; Ding, Ping

    2012-10-01

    Habitat fragmentation is a main cause for the loss of biological diversity. Combining line-transect methods to survey the amphibians and reptiles on 23 islands on Thousand Island Lake in Zhejiang province, along with survey data on nearby plant species and habitat variables collected by GIS, we used the"BINMATNEST (binary matrix nestedness temperature calculator)" software and the Spearman rank correlation to examine whether amphibians and reptiles followed nested subsets and their influencing factors. The results showed that amphibians and reptiles were significantly nested, and that the island area and habitat type were significantly associated with their nested ranks. Therefore, to effectively protect amphibians and reptiles in the Thousand Islands Lake area we should pay prior attention to islands with larger areas and more habitat types.

  5. Forty-two years of Revista Mexicana de Astronomía y Astrofísica: Some history and musings on the future

    Science.gov (United States)

    Allen, C.; Torres-Peimbert, S.

    2017-07-01

    After 42 years of continuously publishing the Revista Mexicana de Astronomía y Astrofísica, we cast a short retrospective view on its history and we share our plans for the future. RMxAA was founded in 1974. Founding editors were P. Pishmish, E. Mendoza and S. Torres-Peimbert. RMxAA has published original research papers in all areas of astronomy, astrophysics and related fields. Until 1994 RMxAA also published the proceedings of astronomical conferences held in México and Latin America. Since 1995 a Series devoted exclusively to such proceedings was founded, RMxAC, Revista Mexicana de Astronomía y Astrofísica (Serie de Conferencias). All papers submitted to RMxAA are sent to internationally recognized experts to be strictly refereed. RMxAA is included in Current Contents, Science Citation Index and other relevant international indexes. Both publications are fully integrated into the ADS. Their contents have always been freely available to the general public. All this ensures a wide international visibility, comparable to that of the best astronomical journals. The impact factor of RMxAA has varied over the years, mostly as a consequence of small number statistics. The average impact factor is about 2.4, far larger than that of all but a few Latin American scientific journals. The editorial independence of RMxAA, the fact that there are no page charges for authors, and that the printed version is distributed free of charge to astronomical libraries all over the world motivate us to look forward with optimism to many more years of publication. In view of recent developments in the scientific publishing field, we have applied to obtain the DOI for the published papers, and are in the process of becoming an all-electronic publication.

  6. Analysis of results of checks IMRT in almost a thousand patients

    International Nuclear Information System (INIS)

    Richart, J.; Doval, S.; Perez-Calatayud, J.; Depieaggio, M.; Rodriguez, S.; Santos, M.

    2013-01-01

    Since November 2006 IMRT treatments being made in the mode of sliding-window in our Hospital. The major sites of application of this technique are: head and neck, prostate, and gynecological. Specific checks are performed of each plan both yield and analysis ionometric extent in which a dummy was exported IMRT plan. Over one thousand patients, the objective of this work is the presentation and analysis of results. (Author)

  7. Effects of habitat fragmentation on avian nest predation risk in Thousand Island Lake, Zhejiang Province

    OpenAIRE

    Jiji Sun; Siyu Wang; Yanping Wang; Deyu Shao; Ping Ding

    2011-01-01

    To investigate the effects of habitat fragmentation on avian nest predation risk, we placed 726 artificial ground nests with chicken or quail (Coturnix japonica) eggs on 16 islands in edge and interiorlocations in Thousand Island Lake from April to August 2010. We compared nest predation rates between nests with different egg types and between the nests located at different distances from the edge. We also evaluated the relationships between nest predation and island area, isolation, shape in...

  8. CHWs get credit: a 10-year history of the first college-credit certificate for community health workers in the United States.

    Science.gov (United States)

    Love, Mary Beth; Legion, Vicki; Shim, Janet K; Tsai, Cindy; Quijano, Vickie; Davis, Catherine

    2004-10-01

    Community health workers have become increasingly important in the U.S. health care system, playing a significant role in basic health promotion and care coordination; however, their status and visibility have not kept pace with their wider use. A major impediment has been the absence of systematic preparation-the field needs standardized education in programs that emphasize the actual skills and knowledge used by community health workers, programs that attract and retain nontraditional students from underserved communities and that foster professional advancement. This article chronicles the 10-year history of the first college credit-bearing community health worker certificate program in the country to address this need. Systematic research resulted in a program centered on the core competencies universally practiced by community health workers regardless of their topical focus. The certificate program combines performance-based methods with popular education into an innovative pedagogical approach that teaches skills, while solidifying, contextualizing, and enhancing crucial experiential knowledge. Program outcomes validate the approach.

  9. Rediscovery of the 220-year-old holotype of the Banded Iguana, Brachylophus fasciatus (Brongniart, 1800) in the Paris Natural History Museum

    Science.gov (United States)

    Ineich, Ivan; Fisher, Robert N.

    2016-01-01

    The Paris Natural History Museum herpetological collection (MNHN-RA) has seven historical specimens of Brachylophus spp. collected late in the 18th and early in the 19th centuries. Brachylophus fasciatus was described in 1800 by Brongniart but its type was subsequently considered as lost and never present in MNHN-RA collections. We found that 220 year old holotype among existing collections, registered without any data, and we show that it was donated to MNHN-RA from Brongniart’s private collection after his death in 1847. It was registered in the catalogue of 1851 but without any data or reference to its type status. According to the coloration (uncommon midbody saddle-like dorsal banding pattern) and morphometric data given in its original description and in the subsequent examination of the type in 1802 by Daudin and in 1805 by Brongniart we found that lost holotype in the collections. Another MNHN-RA specimen has Horn Islands (Wallis and Futuna) as the collection location but we show that most of the collections given to MNHN-RA by its collector, Louis Arnoux, have mixed localities in the MNHN-RA catalogues. We thus conclude that the locality is wrong and that the species never inhabited those islands located west of Western Samoa and north-east of Fiji.

  10. Rediscovery of the 220-year-old holotype of the Banded Iguana, Brachylophus fasciatus (Brongniart, 1800) in the Paris Natural History Museum.

    Science.gov (United States)

    Ineich, Ivan; Fisher, Robert N

    2016-07-15

    The Paris Natural History Museum herpetological collection (MNHN-RA) has seven historical specimens of Brachylophus spp. collected late in the 18th and early in the 19th centuries. Brachylophus fasciatus was described in 1800 by Brongniart but its type was subsequently considered as lost and never present in MNHN-RA collections. We found that 220 year old holotype among existing collections, registered without any data, and we show that it was donated to MNHN-RA from Brongniart's private collection after his death in 1847. It was registered in the catalogue of 1851 but without any data or reference to its type status. According to the coloration (uncommon midbody saddle-like dorsal banding pattern) and morphometric data given in its original description and in the subsequent examination of the type in 1802 by Daudin and in 1805 by Brongniart we found that lost holotype in the collections. Another MNHN-RA specimen has Horn Islands (Wallis and Futuna) as the collection location but we show that most of the collections given to MNHN-RA by its collector, Louis Arnoux, have mixed localities in the MNHN-RA catalogues. We thus conclude that the locality is wrong and that the species never inhabited those islands located west of Western Samoa and north-east of Fiji.

  11. The Comparative Reliability and Feasibility of the Past-Year Canadian Diet History Questionnaire II: Comparison of the Paper and Web Versions

    Directory of Open Access Journals (Sweden)

    Geraldine Lo Siou

    2017-02-01

    Full Text Available Advances in technology-enabled dietary assessment include the advent of web-based food frequency questionnaires, which may reduce costs and researcher burden but may introduce new challenges related to internet connectivity and computer literacy. The purpose of this study was to evaluate the intra- and inter-version reliability, feasibility and acceptability of the paper and web Canadian Diet History Questionnaire II (CDHQ-II in a sub-sample of 648 adults (aged 39–81 years recruited from Alberta’s Tomorrow Project. Participants were randomly assigned to one of two groups: (1 paper, web, paper; or (2 web, paper, web over a six-week period. With few exceptions, no statistically significant differences in mean nutrient intake were found in the intra- and inter-version reliability analyses. The majority of participants indicated future willingness to complete the CDHQ-II online, and 59% indicated a preference for the web over the paper version. Findings indicate that, in this population of adults drawn from an existing cohort, the CDHQ-II may be administered in paper or web modalities (increasing flexibility for questionnaire delivery, and the nutrient estimates obtained with either version are comparable. We recommend that other studies explore the feasibility and reliability of different modes of administration of dietary assessment instruments prior to widespread implementation.

  12. The Comparative Reliability and Feasibility of the Past-Year Canadian Diet History Questionnaire II: Comparison of the Paper and Web Versions

    Science.gov (United States)

    Lo Siou, Geraldine; Csizmadi, Ilona; Boucher, Beatrice A.; Akawung, Alianu K.; Whelan, Heather K.; Sharma, Michelle; Al Rajabi, Ala; Vena, Jennifer E.; Kirkpatrick, Sharon I.; Koushik, Anita; Massarelli, Isabelle; Rondeau, Isabelle; Robson, Paula J.

    2017-01-01

    Advances in technology-enabled dietary assessment include the advent of web-based food frequency questionnaires, which may reduce costs and researcher burden but may introduce new challenges related to internet connectivity and computer literacy. The purpose of this study was to evaluate the intra- and inter-version reliability, feasibility and acceptability of the paper and web Canadian Diet History Questionnaire II (CDHQ-II) in a sub-sample of 648 adults (aged 39–81 years) recruited from Alberta’s Tomorrow Project. Participants were randomly assigned to one of two groups: (1) paper, web, paper; or (2) web, paper, web over a six-week period. With few exceptions, no statistically significant differences in mean nutrient intake were found in the intra- and inter-version reliability analyses. The majority of participants indicated future willingness to complete the CDHQ-II online, and 59% indicated a preference for the web over the paper version. Findings indicate that, in this population of adults drawn from an existing cohort, the CDHQ-II may be administered in paper or web modalities (increasing flexibility for questionnaire delivery), and the nutrient estimates obtained with either version are comparable. We recommend that other studies explore the feasibility and reliability of different modes of administration of dietary assessment instruments prior to widespread implementation. PMID:28208819

  13. EnviroInfo 2016. Environmental informatics. Stability, continuity, innovation. Current trends and future perspectives based on 30 years of history. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Wohlgemuth, Volker; Fuchs-Kittowski, Frank; Wittmann, Jochen (eds.) [Hochschule fuer Technik und Wirtschaft, Berlin (Germany)

    2016-07-01

    This book covers selected keynotes, short papers and work in progress papers of the 30th edition of the long standing and established international and interdisciplinary conference series on leading environmental information and communication technologies (Envirolnfo 2016). The conference was held in September 14 - 16, 2016 at the Hochschule fiir Technik und Wirtschaft Berlin (HTW Berlin), University of Applied Sciences. Basic topics that were covered under the central focus ''Environmental Informatics - Current trends and future perspectives based on 30 years of history'' were applications of geographical information systems, environmental modelling and simulation, risk management, material and energy flow management, climate change, tools and database applications and other aspects with regard to the main topic ICT and the environment. Due to the interdisciplinary character of environmental informatics, one important goal of this conference was to bring experts from industry, research and education together to exchange ideas and proposals for solution of urgent problems and needs in the field on environmental protection and it's IT-support. Three papers are separately analyzed for this database.

  14. 60 Years of Southwestern Archaeology, A History of the Pecos Conference, by Richard B. Woodbury, University of New Mexico Press, Albuquerque, 1993.

    OpenAIRE

    Reyman, Jonathan E.

    1993-01-01

    Among the least commendable characteristics of the New Archaeology is a marked anti-historical perspective. The history of archaeology and much, if not most, of earlier theory, method, and the results of fieldwork are considered not worth knowing or irrelevant, especially for graduate education: "graduate courses in anthropology should cease being histories of thought" (Schiffer 1976:193). Regrettably, New Archaeologists generally ad...

  15. The Intricacies of Education about the Holocaust in Poland. Ten Years after the Jedwabne Debate, What Can Polish School Students Learn about the Holocaust in History Classes?

    Science.gov (United States)

    Ambrosewicz-Jacobs, Jolanta; Szuchta, Robert

    2014-01-01

    In many European countries, disparities have grown between history and the memory of the Holocaust. Debates on Polish-Jewish relations during the Holocaust and empirical studies in the field of education reveal that there is a gap between research and education. The emphasis in this paper is on the content of new history textbooks published after…

  16. Job insecurity and the use of antidepressant medication among Danish employees with and without a history of prolonged unemployment: a 3.5-year follow-up study

    DEFF Research Database (Denmark)

    Rugulies, R; Thielen, K; Nygaard, E

    2010-01-01

    A study was undertaken to investigate whether job insecurity predicts incident use of antidepressant medication and whether the association is modified by a history of prolonged unemployment.......A study was undertaken to investigate whether job insecurity predicts incident use of antidepressant medication and whether the association is modified by a history of prolonged unemployment....

  17. IgG4-related retroperitoneal fibrosis and sclerosing cholangitis independent of autoimmune pancreatitis. A recurrent case after a 5-year history of spontaneous remission.

    Science.gov (United States)

    Miura, Hideaki; Miyachi, Yasutaka

    2009-07-06

    A new clinicopathological concept of IgG4-related sclerosing disease affecting various organs has recently been proposed in relation to autoimmune pancreatitis. This report describes the case of IgG4-related retroperitoneal fibrosis and sclerosing cholangitis independent of autoimmune pancreatitis, which recurred after a long period of spontaneous remission. An 80-year-old Japanese man presented with obstructive jaundice owing to a hepatic hilum bile duct stricture. Coincidentally, a soft tissue mass surrounding the abdominal aorta, suggesting retroperitoneal fibrosis, was identified. Unexpectedly, spontaneous regression of obstructive jaundice together with retroperitoneal fibrosis occurred. The presence of high serum IgG4 concentrations measured later led us to consider a possible association with autoimmune pancreatitis; however, there were no clinical features confirming autoimmune pancreatitis. After a 5-year history of spontaneous clinical remission, there was an elevation of serum IgG4 levels and renal dysfunction owing to bilateral hydronephrosis caused by a reemergence of the retroperitoneal mass. Evaluation by endoscopic retrograde cholangiopancreatography revealed a biliary stricture, suggesting sclerosing cholangitis which was observed without the presence of any pancreatic duct abnormality. The subsequent excellent results obtained using steroid therapy, namely the decrease in serum IgG4 levels and the regression of the retroperitoneal mass, strongly suggested that the present case was an IgG4-related sclerosing disease. Aside from high serum IgG4 concentrations, markedly elevated levels of serum IgE was found retrospectively, although the clinical significance remains unknown. When we encounter fibrotic diseases of unknown etiology, we should measure serum IgG4 concentrations and monitor the disease activity over long periods even after achieving clinical remission.

  18. Contamination history of suspended river sediments accumulated in oxbow lakes over the last 25 years. Morava river (Danube catchment area), Czech Republic

    International Nuclear Information System (INIS)

    Babek, O.

    2008-01-01

    Background, aims, and scope Embankment of meandering river systems in many industrial areas results in the formation of artificial oxbow lakes that may act as perennial or intermittent traps for river sediments. Their deposits can be dated using a combination of historical and stratigraphic data, providing a good means to study historical records of contamination transported by rivers. Contamination history over the last few decades is of special significance for Central and Eastern Europe as it can reflect high pollutant levels in the second half of the twentieth century and the subsequent improvement after the fall of the Iron Curtain. The purpose of this study was to investigate recent sediments of an oxbow lake of the Morava River, Czech Republic, their stratigraphic records, sediment architecture, and history of contamination. Materials and methods Seven ground-penetrating radar (GPR) profiles and three sediment cores up to 4 m deep were studied. The stratigraphy of the cores was inferred from visible-light spectrophotometry, X-ray radiography, grain size analysis, and semiquantitative modal analysis of sandy fractions. The sediments were dated using the 137 Cs mass activity and combinations of stratigraphic and historical data. The cores were sampled for concentrations of heavy metals and persistent organic pollutants. Wet sampled, lyophilized, and sieved sediments were extracted and analyzed for heavy metals by inductively coupled plasma mass spectrometry (ICP-MS) of aqua regia leachate and for persistent organic pollutants by gas chromatography (GC-ECD and GC-MS). Results Three distinct sedimentary sequences (S1, S2, and S3) were identified. The basal sequence S1 represents river channel sediments deposited before the formation of the oxbow lake, most likely before the 1930s. The boundary between the S1 and S2 sequence correlates with the level of sediment dredging from 1981 evidenced from historical data. The overlying sequences S2 and S3 represent a

  19. Control of geomorphic processes on Be-10 concentrations in individual clasts : complexity of the exposure history in Gobi-Altay range (Mongolia)

    OpenAIRE

    Vassallo, R.; Ritz, J. F.; Carretier, Sébastien

    2011-01-01

    The dating of alluvial landforms by cosmogenic nuclides requires distinguishing the pre-deposition inheritance from the post-deposition history of the clasts in the studied marker. Moreover, estimating catchment-scale erosion rates from the concentrations of cosmogenic nuclides in active alluvia requires a good knowledge of the local/regional relationships between rock exhumation and transport through space and time. This is still poorly known for timescales of tens of thousand years. In orde...

  20. Radial velocities for the HIPPARCOS-Gaia Hundred-Thousand-Proper-Motion project

    Science.gov (United States)

    de Bruijne, J. H. J.; Eilers, A.-C.

    2012-10-01

    Context. The Hundred-Thousand-Proper-Motion (HTPM) project will determine the proper motions of ~113 500 stars using a ~23-year baseline. The proper motions will be based on space-based measurements exclusively, with the Hipparcos data, with epoch 1991.25, as first epoch and with the first intermediate-release Gaia astrometry, with epoch ~2014.5, as second epoch. The expected HTPM proper-motion standard errors are 30-190 μas yr-1, depending on stellar magnitude. Aims: Depending on the astrometric characteristics of an object, in particular its distance and velocity, its radial velocity can have a significant impact on the determination of its proper motion. The impact of this perspective acceleration is largest for fast-moving, nearby stars. Our goal is to determine, for each star in the Hipparcos catalogue, the radial-velocity standard error that is required to guarantee a negligible contribution of perspective acceleration to the HTPM proper-motion precision. Methods: We employ two evaluation criteria, both based on Monte-Carlo simulations, with which we determine which stars need to be spectroscopically (re-)measured. Both criteria take the Hipparcos measurement errors into account. The first criterion, the Gaussian criterion, is applicable to nearby stars. For distant stars, this criterion works but returns overly pessimistic results. We therefore use a second criterion, the robust criterion, which is equivalent to the Gaussian criterion for nearby stars but avoids biases for distant stars and/or objects without literature radial velocity. The robust criterion is hence our prefered choice for all stars, regardless of distance. Results: For each star in the Hipparcos catalogue, we determine the confidence level with which the available radial velocity and its standard error, taken from the XHIP compilation catalogue, are acceptable. We find that for 97 stars, the radial velocities available in the literature are insufficiently precise for a 68.27% confidence

  1. 75 FR 68351 - Thousand Springs Wind Park, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Science.gov (United States)

    2010-11-05

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-1887-000] Thousand Springs Wind Park, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... proceeding of Thousand Springs Wind Park, LLC's application for market-based rate authority, with an...

  2. Direct Mutagenesis of Thousands of Genomic Targets using Microarray-derived Oligonucleotides

    DEFF Research Database (Denmark)

    Bonde, Mads; Kosuri, Sriram; Genee, Hans Jasper

    2015-01-01

    Multiplex Automated Genome Engineering (MAGE) allows simultaneous mutagenesis of multiple target sites in bacterial genomes using short oligonucleotides. However, large-scale mutagenesis requires hundreds to thousands of unique oligos, which are costly to synthesize and impossible to scale...... operons in E. coli using this method, which we call Microarray-Oligonucleotide (MO)-MAGE. The resulting mutant library was characterized by high-throughput sequencing to show that all attempted insertions were estimated to have occurred at an average frequency of 0.02 % per loci with 0.4 average...

  3. Teaching-service integration and social impact in 50 years of public health history School of Dentistry of the “Universidade Estadual Paulista Júlio de Mesquita Filho”

    Directory of Open Access Journals (Sweden)

    Nemre Adas Saliba

    2009-12-01

    Full Text Available To verify the projects and programs developed during the course of 50-year history of School of Dentistry Aracatuba of the “Universidade Estadual Paulista Júlio de Mesquita Filho” (State of São Paulo -Brazil, in the public health area, in agreement with the dental models of attendance and considering the background and the progress of the Public Health policies in Brazil, with the aim of reporting on the experience of integrating teaching-service, professional education and the social impact. A documentary research of a descriptive nature was conducted, by consulting the institutional files of the Dental Faculty, considering; official texts, reports, documents, databases and publications, with reference to the period from 1957 to 2007. The descriptive analysis demonstrated that the main actions developed were: Campaign for home filters, Campaign for construction of Wells and Sewages, Campaign for Fluoridation of the Araçatuba and Area Water Supply, Epidemiologic Surveys, Extramural Dental services, Extension projects; Attendance to pregnant women, the elderly and children, Oral cancer prevention program, Program for Heterogeneous Fluoride control, Creation of master’s degree program, Municipal health counselor training courses, Training of State of São Paulo Family Health Program community agents and teams, Advisory services to municipalities and production of didactic-pedagogic materials for health education. Several programs have been and are being developed, with successful health practices in the area, accompanying the progress of health policies and promoting professional education with integration of the university into the local health and community services.

  4. Natural history of motor neuron disease in adult onset GM2-gangliosidosis: A case report with 25 years of follow-up

    Directory of Open Access Journals (Sweden)

    Mauro Scarpelli

    2014-01-01

    GM2-gangliosidosis can manifest as a motor neuron disease with a slowly progressive course. The correct knowledge of the natural history can be really important to achieve the diagnosis, design new therapies and evaluate clinical trials.

  5. Spinocellular carcinoma from warts in a HPV infection natural history lasting 49 years. Virus strategy or host choice? Implications for researches and therapeutic vaccines.

    Science.gov (United States)

    Criscione, S M

    2011-11-01

    There is a very strong evidence that progression (also to cancer) in variable percentages of cases infected by HPV, HBV, HCV, and HIV depends on host immune response. A large number of observations demonstrate that virus set up a postulated "active strategy" to modify host reactions or to avoid it. But in all those infections it also seems that antigen load (viral RNA or DNA), chronic activation of immune response and time elapsing from the primary infection play a pivotal role in determining clearing or persisting outcomes. My wife's HPV and cancer natural history, lasting 49 years, started at the age of 10 years with facial warts and progressed to CIN 2/3, cervical in situ carcinoma, perineal warts, perianal carcinoma, inguinal lymph nodes, and invasion of bones and muscular structures, until death is paradigmatic: a progressive immune failure was detected in her scaling up all those clinical features, ending in a massive apoptosis of her lymphocytes collected by leukapheresis and cultured with HPV antigens E6/E7, with the aim of obtaining antigen presenting cells and CD8+ specific T lymphocytes. From this experience, a concept of "host choice to reach a tolerance (mainly by a Tregs mediated anergy) or symbiotic-like state" arises, underlining all the affected host's immune-responses to virus persistence (and to consequent tumors). It might be then postulated as the hallmark of a long-term host/parasites co-evolution, and considered a "normal" reaction when the host faces overwhelming numbers of non-self cancer cells (high antigen loads) preceded by persistent virus infections (chronic activation). This happens in patients who do not clear HPV or other viruses soon enough after infection. These observations may lead to a better understanding of many phenomena that are actually difficult to explain or still are open questions. The auto-limiting host's immune-responses are likely to be aimed to avoid risks arising mainly in the protection of "self" (autoimmunity

  6. Test-based age-of-acquisition norms for 44 thousand English word meanings.

    Science.gov (United States)

    Brysbaert, Marc; Biemiller, Andrew

    2017-08-01

    Age of acquisition (AoA) is an important variable in word recognition research. Up to now, nearly all psychology researchers examining the AoA effect have used ratings obtained from adult participants. An alternative basis for determining AoA is directly testing children's knowledge of word meanings at various ages. In educational research, scholars and teachers have tried to establish the grade at which particular words should be taught by examining the ages at which children know various word meanings. Such a list is available from Dale and O'Rourke's (1981) Living Word Vocabulary for nearly 44 thousand meanings coming from over 31 thousand unique word forms and multiword expressions. The present article relates these test-based AoA estimates to lexical decision times as well as to AoA adult ratings, and reports strong correlations between all of the measures. Therefore, test-based estimates of AoA can be used as an alternative measure.

  7. The cytoplasm of living cells: a functional mixture of thousands of components

    International Nuclear Information System (INIS)

    Sear, Richard P

    2005-01-01

    Inside every living cell is the cytoplasm: a fluid mixture of thousands of different macromolecules, predominantly proteins. This mixture is where most of the biochemistry occurs that enables living cells to function, and it is perhaps the most complex liquid on earth. Here we take an inventory of what is actually in this mixture. Recent genome-sequencing work has given us for the first time at least some information on all of these thousands of components. Having done so we consider two physical phenomena in the cytoplasm: diffusion and possible phase separation. Diffusion is slower in the highly crowded cytoplasm than in dilute solution. Reasonable estimates of this slow-down can be obtained and their consequences explored; for example, monomer-dimer equilibria are established approximately 20 times more slowly than in a dilute solution. Phase separation in all except exceptional cells appears not to be a problem, despite the high density and so strong protein-protein interactions present. We suggest that this may be partially a by-product of the evolution of other properties, and partially a result of the huge number of components present

  8. Enhanced annotations and features for comparing thousands of Pseudomonas genomes in the Pseudomonas genome database.

    Science.gov (United States)

    Winsor, Geoffrey L; Griffiths, Emma J; Lo, Raymond; Dhillon, Bhavjinder K; Shay, Julie A; Brinkman, Fiona S L

    2016-01-04

    The Pseudomonas Genome Database (http://www.pseudomonas.com) is well known for the application of community-based annotation approaches for producing a high-quality Pseudomonas aeruginosa PAO1 genome annotation, and facilitating whole-genome comparative analyses with other Pseudomonas strains. To aid analysis of potentially thousands of complete and draft genome assemblies, this database and analysis platform was upgraded to integrate curated genome annotations and isolate metadata with enhanced tools for larger scale comparative analysis and visualization. Manually curated gene annotations are supplemented with improved computational analyses that help identify putative drug targets and vaccine candidates or assist with evolutionary studies by identifying orthologs, pathogen-associated genes and genomic islands. The database schema has been updated to integrate isolate metadata that will facilitate more powerful analysis of genomes across datasets in the future. We continue to place an emphasis on providing high-quality updates to gene annotations through regular review of the scientific literature and using community-based approaches including a major new Pseudomonas community initiative for the assignment of high-quality gene ontology terms to genes. As we further expand from thousands of genomes, we plan to provide enhancements that will aid data visualization and analysis arising from whole-genome comparative studies including more pan-genome and population-based approaches. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  9. Nuclear Fractionation Reveals Thousands of Chromatin-Tethered Noncoding RNAs Adjacent to Active Genes

    Directory of Open Access Journals (Sweden)

    Michael S. Werner

    2015-08-01

    Full Text Available A number of long noncoding RNAs (lncRNAs have been reported to regulate transcription via recruitment of chromatin modifiers or bridging distal enhancer elements to gene promoters. However, the generality of these modes of regulation and the mechanisms of chromatin attachment for thousands of unstudied human lncRNAs remain unclear. To address these questions, we performed stringent nuclear fractionation coupled to RNA sequencing. We provide genome-wide identification of human chromatin-associated lncRNAs and demonstrate tethering of RNA to chromatin by RNAPII is a pervasive mechanism of attachment. We also uncovered thousands of chromatin-enriched RNAs (cheRNAs that share molecular properties with known lncRNAs. Although distinct from eRNAs derived from active prototypical enhancers, the production of cheRNAs is strongly correlated with the expression of neighboring protein-coding genes. This work provides an updated framework for nuclear RNA organization that includes a large chromatin-associated transcript population correlated with active genes and may prove useful in de novo enhancer annotation.

  10. Leveraging the Thousands of Known Planets to Inform TESS Follow-Up

    Science.gov (United States)

    Ballard, Sarah

    2017-10-01

    The Solar System furnishes our most familiar planetary architecture: many planets, orbiting nearly coplanar to one another. However, a typical system of planets in the Milky Way orbits a much smaller M dwarf star, and these stars furnish a different blueprint in key ways than the conditions that nourished evolution of life on Earth. With ensemble studies of hundreds-to-thousands of exoplanets, I will describe the emerging links between planet formation from disks, orbital dynamics of planets, and the content and observability of planetary atmospheres. These quantities can be tied to observables even in discovery light curves, to enable judicious selection of follow-up targets from the ground and from space. After TESS exoplanet discoveries start in earnest, the studies of individual planets with large, space-based platforms comprise the clear next step toward understanding the hospitability of the Milky Way to life. Our success hinges upon leveraging the many thousands of planet discoveries in hand to determine how to use these precious and limited resources.

  11. Writing American Indian History

    Science.gov (United States)

    Noley, Grayson B.

    2008-01-01

    The purpose of this paper is to critique the manner in which history about American Indians has been written and propose a rationale for the rethinking of what we know about this subject. In particular, histories of education as regards the participation of American Indians is a subject that has been given scant attention over the years and when…

  12. An analysis of gamma ray burst time histories

    Science.gov (United States)

    Lestrade, John Patrick; Karr, Gerald R.

    1994-01-01

    Gamma ray burst time histories, ranging in durations from milliseconds to thousands of seconds, are as varied as the number of bursts. They show a wide array of structures from those that are very smooth to those that contain a seemingly uncountable number of spikes riding on top of other spikes. These profiles have tantalized researchers for years - they obviously hold important information on the nature of GRB's, but to date no one has been successful in analyzing them. For the past year the author has been working on algorithms to analyze these data. Two approaches have been followed in this investigation. The first is an attempt to quantify the amount of structure, or spikiness, in a profile. The second involves applying the latest theorems on chaos and fractals with the aim of extracting useful information from what seems to be a random collection of shot noise.

  13. Histories electromagnetism

    International Nuclear Information System (INIS)

    Burch, Aidan

    2004-01-01

    Working within the HPO (History Projection Operator) Consistent Histories formalism, we follow the work of Savvidou on (scalar) field theory [J. Math. Phys. 43, 3053 (2002)] and that of Savvidou and Anastopoulos on (first-class) constrained systems [Class. Quantum Gravt. 17, 2463 (2000)] to write a histories theory (both classical and quantum) of Electromagnetism. We focus particularly on the foliation-dependence of the histories phase space/Hilbert space and the action thereon of the two Poincare groups that arise in histories field theory. We quantize in the spirit of the Dirac scheme for constrained systems

  14. Neurotoxicity in breast cancer survivors a parts per thousand yen10 years post-treatment is dependent on treatment type

    NARCIS (Netherlands)

    Stouten-Kemperman, Myrle M.; de Ruiter, Michiel B.; Koppelmans, Vincent; Boogerd, Willem; Reneman, Liesbeth; Schagen, Sanne B.

    2015-01-01

    Adjuvant chemotherapy (CT) for breast cancer (BC) is associated with very late side-effects on brain function and structure. However, little is known about neurotoxicity of specific treatment regimens. To compare neurotoxicity profiles after different treatment strategies, we used neurocognitive

  15. A record of the last 460 thousand years of upper ocean stratification from the central Walvis Ridge, South Atlantic

    NARCIS (Netherlands)

    Scussolini, P.; Peeters, F.J.C.

    2013-01-01

    The upper branch of the Atlantic Meridional Overturning Circulation predominantly enters the Atlantic Ocean through the southeast, where the subtropical gyre is exposed to the influence of the Agulhas leakage (AL). To understand how the transfer of Indian Ocean waters via the AL affected the upper

  16. Weapons of Maths Instruction: A Thousand Years of Technological Stasis in Arrowheads from the South Scandinavian Middle Mesolithic

    Directory of Open Access Journals (Sweden)

    Kevan Edinborough

    2005-11-01

    Full Text Available This paper presents some results from my doctoral research into the evolution of bow-arrow technology using archaeological data from the south Scandinavian Mesolithic (Edinborough 2004. A quantitative approach is used to describe the morphological variation found in samples taken from over 3600 armatures from nine Danish and Swedish lithic assemblages. A linked series of statistical techniques determines the two most significant metric variables across the nine arrowhead assemblages in terms of the cultural transmission of arrowhead technology. The resultant scatterplot uses confidence ellipses to reveal highly distinctive patterns of morphological variation that are related to population-specific technological traditions. A population-level hypothesis of a socially constrained transmission mechanism is presented that may explain the unusually long period of technological stasis demonstrated by six of the nine arrowhead phase-assemblages.

  17. Immigration Enforcement Actions: Fiscal Year 2011

    Data.gov (United States)

    Department of Homeland Security — Each year, the Department of Homeland Security (DHS) undertakes immigration enforcement actions involving hundreds of thousands of foreign nationals. These actions...

  18. Immigration Enforcement Actions: Fiscal Year 2004

    Data.gov (United States)

    Department of Homeland Security — Each year, the Department of Homeland Security (DHS) undertakes immigration enforcement actions involving hundreds of thousands of foreign nationals. These actions...

  19. Immigration Enforcement Actions: Fiscal Year 2012

    Data.gov (United States)

    Department of Homeland Security — Each year, the Department of Homeland Security (DHS) undertakes immigration enforcement actions involving hundreds of thousands of foreign nationals. These actions...

  20. Immigration Enforcement Actions: Fiscal Year 2010

    Data.gov (United States)

    Department of Homeland Security — Each year, the Department of Homeland Security (DHS) undertakes immigration enforcement actions involving hundreds of thousands of foreign nationals. These actions...

  1. Combined Effects of Family History of Cardiovascular Disease and Serum C-reactive Protein Level on the Risk of Stroke: A 9.2-year Prospective Study among Mongolians in China.

    Science.gov (United States)

    Zhu, Zheng Bao; Huangfu, Xin Feng; Zhong, Chong Ke; Zhou, Yi Peng; Tian, Yun Fan; Buren, Batu; Xu, Tian; Wang, Ai Li; Li, Hong Mei; Zhang, Ming Zhi; Zhang, Yong Hong

    2017-09-01

    We aimed to evaluate the combined effect of a family history of cardiovascular disease (CVD) and high serum C-reactive protein (CRP) on the stroke incidence in an Inner Mongolian population in China. A prospective cohort study was conducted from June 2002 to July 2012, with 2,544 participants aged 20 years and over from Inner Mongolia, China. We categorized participants into four groups based on the family history of CVD and CRP levels. We adjusted for age; sex; smoking; drinking; hypertension; body mass index; waist circumference; and blood glucose, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels. Compared with the group with no family history of CVD/low CRP levels, the group with family history of CVD/high CRP levels had a hazard ratio (HR) of 1.78 [95% confidence interval (CI), 1.03-3.07; P = 0.039] of stroke, and an HR of 2.14 (95% CI, 1.09-4.20; P = 0.027) of ischemic stroke. The HRs of hemorrhagic stroke for the other three groups were not statistically significant (all P > 0.05). Participants with both a family history of CVD and high CRP levels had the highest stroke incidence, suggesting that high CRP levels may increase stroke risk, especially of ischemic stroke, among individuals with a family history of CVD. Copyright © 2017 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

  2. Ranking economic history journals

    DEFF Research Database (Denmark)

    Di Vaio, Gianfranco; Weisdorf, Jacob Louis

    2010-01-01

    This study ranks-for the first time-12 international academic journals that have economic history as their main topic. The ranking is based on data collected for the year 2007. Journals are ranked using standard citation analysis where we adjust for age, size and self-citation of journals. We also...... compare the leading economic history journals with the leading journals in economics in order to measure the influence on economics of economic history, and vice versa. With a few exceptions, our results confirm the general idea about what economic history journals are the most influential for economic...... history, and that, although economic history is quite independent from economics as a whole, knowledge exchange between the two fields is indeed going on....

  3. Marine Environmental History

    DEFF Research Database (Denmark)

    Poulsen, Bo

    2012-01-01

    This essay provides an overview of recent trends in the historiography of marine environmental history, a sub-field of environmental history which has grown tremendously in scope and size over the last c. 15 years. The object of marine environmental history is the changing relationship between...... human society and natural marine resources. Within this broad topic, several trends and objectives are discernable. The essay argue that the so-called material marine environmental history has its main focus on trying to reconstruct the presence, development and environmental impact of past fisheries...... and whaling operations. This ambition often entails a reconstruction also of how marine life has changed over time. The time frame rages from Paleolithicum to the present era. The field of marine environmental history also includes a more culturally oriented environmental history, which mainly has come...

  4. Ranking Economic History Journals

    DEFF Research Database (Denmark)

    Di Vaio, Gianfranco; Weisdorf, Jacob Louis

    This study ranks - for the first time - 12 international academic journals that have economic history as their main topic. The ranking is based on data collected for the year 2007. Journals are ranked using standard citation analysis where we adjust for age, size and self-citation of journals. We...... also compare the leading economic history journals with the leading journals in economics in order to measure the influence on economics of economic history, and vice versa. With a few exceptions, our results confirm the general idea about what economic history journals are the most influential...... for economic history, and that, although economic history is quite independent from economics as a whole, knowledge exchange between the two fields is indeed going on....

  5. Environmental changes, forest history and human impact in the southern part of Valdai Hills (European Russia) during the last 7000 years

    Science.gov (United States)

    Novenko, Elena; Tsyganov, Andery; Pisarchuk, Natalia; Kozlov, Daniil

    2017-04-01

    Understanding the long-term ecological dynamics of swampy boreal forest is essential for assessment of the possible responses and feedbacks of forest ecosystems to climate change and natural disturbance. The multi-proxy record from the Central Forest State Natural Biosphere Reserve (CFSNBR), locate on the South of Valdai Hills, provides important new data on the forest history, human impact, paludification dynamics and environmental changes in the central part of the East European Plain during the Holocene. The results of peat humification, pollen, plant macrofossil, micro charcoal and testate amoeba analyses from forest pealand show that between 7000 and 4000 cal yr BP the southern part of Valdai Hills was occupied by broad-leaved forests. Spruce occurred in forest communities as small admixture and gradually increased its abundance. After 4000 cal yr BP spruce rapidly become the main forest forming species, however broad-leaved trees took place in plant cover. Despite significant climatic fluctuation, mixed broad-leaved-spruce forests persisted in vegetation until 900 cal yr BP and then were replaced by waterlogged herbal spruce forests. The extensive Sphagnum spruce forests are recent plant communities and were formed during the last 100 years that could be explain by changes in water balance of the territory due to both climate and anthropogenic factors. According to reconstruction of Mid- and Late Holocene climate changes, warm and relatively dry period of the Holocene Thermal Maximum (7000-5500 cal yr BP) was followed by climate cooling that included several relatively cold phases at about 5000, 3500, 2000, 1200 cal yr BP and warm intervals at about 2600, 1500 and 900 cal yr BP. The distinct cooling was reconstructed between 800 and 400 cal yr BP, apparently, correlated with the Little Ice Age. Climate dynamics appeared as significant changes of environmental conditions at local ecosystem. Warming phases are indicated by high peat humification and organic

  6. Naître à dix ans d’écart… Born ten years apart : social history and the generational approach

    Directory of Open Access Journals (Sweden)

    Catherine Omnès

    2009-06-01

    Full Text Available Après un bref aperçu sur la place de l'approche générationnelle dans l'historiographie française, la contribution entend montrer la fécondité du concept de génération démographique en histoire sociale. En comparant les trajectoires de deux cohortes d'ouvrières parisiennes nées au début du XXe siècle, à dix ans d'écart, elle souligne comment s'opère la différenciation générationnelle à des moments clés du cycle de vie (formation, temps de la fécondité, retraite par une interaction entre le contexte institutionnel (réactivation de l'apprentissage, développement de l’État-Providence, réformes des retraites, le marché du travail et les choix individuels. Plus largement, par son éclairage sur les progrès de la scolarisation,  sur les arbitrages entre fécondité et activité et sur l'apprentissage de la retraite, elle amène à une relecture de la société française, de ses rigidités et de ses mutations.This paper stresses the place of generational studies by French historians. White must have focused on historical generations (« génération du feu », we concentrate here on demographic generations; its purpose is to underline the fruitfulness of the category in social history. Drawing upon evidence from the life course of two cohorts of Parisian working women born ten years apart before the Worfd War I, the author emphasizes the differences existing between the two generations at various tuming points (getting occupational training, starting a family, retiring. The differenciation is caused by interactions between the labor market, individual choices and the institutional context (further education, the developping Welfare State, the reform of the system of retirement. Coupled with a study of the advances in public Schooling, negociations between fecondity and professional activity and preparation for retirement, our interpretation leads to a reappraisal of French society, seen in both its rigidities and its

  7. How do climate and human impact affect Sphagnum peatlands under oceanic-continental climatic conditions? 2000 years of fire and hydrological history of a bog in Northern Poland

    Science.gov (United States)

    Marcisz, Katarzyna; Tinner, Willy; Colombaroli, Daniele; Kołaczek, Piotr; Słowiński, Michał; Fiałkiewicz-Kozieł, Barbara; Lamentowicz, Mariusz

    2014-05-01

    Climate change affects many natural processes and the same applies to human impact For instance climate change and anthropogenic activities may cause increased fire activity or change peatland dynamics. Currently it is still unknown how Sphagnum peatlands in the oceanic-continental transition zone of Poland may respond to combined effects of heat waves, drought and fire. The aim of the study was to reconstruct the last 2000 years palaeohydrology and fire history at Linje bog in Northern Poland. The main task was to determine the drivers of fire episodes, particularly to identify climatic and anthropogenic forcing. A two-meter peat core was extracted and subsampled with a high resolution. Micro- and macroscopic charcoal analyses were applied to determine past fire activity and the results compared with palaeohydrological reconstructions based on testate amoeba analysis. Palynological human indicators were used to reconstruct human activity. A depth-age model including 20 14C dates was constructed to calculate peat accumulation rates and charcoal influx. We hypothesised that: 1) fire frequency in Northern Poland was determined by climatic conditions (combination of low precipitation and heat waves), as reflected in peatland water table, and that 2) past fire episodes in the last millennium were intensified by human activity. Furthermore climate may have influenced human activity over harvest success and the carrying capacity. Our study shows that fire was important for the studied ecosystem, however, its frequency has increased in the last millennium in concomitance with land use activities. Landscape humanization and vegetation opening were followed by a peatland drying during the Little Ice Age (from ca. AD 1380). Similarly to other palaeoecological studies from Poland, Linje peatland possessed an unstable hydrology during the Little Ice Age. Increased fire episodes appeared shortly before the Little Ice Age and most severe fires were present in the time when

  8. Paleoceanographic history of the Guaymas Basin, Gulf of California, during the past 15,000 years based on diatoms, silicoflagellates, and biogenic sediments

    Science.gov (United States)

    Barron, J.A.; Bukry, D.; Dean, W.E.

    2005-01-01

    High-resolution records of calcium carbonate, biogenic opal, diatoms, and silicoflagellates from western Guaymas Basin gravity core GGC55 and piston core JPC56 and eastern Guaymas Basin DSDP Site 480 reveal a complex paleoceanographic history of the central Gulf of California during the past 15,000 years. Prior to ??? 6.2 ka, the eastern and western Guaymas Basin proxy records were remarkably similar. After conditions similar to those of today during the B??lling-Allerod, the Younger Dryas (YD) saw a major drop in diatom production, coincident with increased calcium carbonate and tropical microfossils suggestive of El Nin??o-like conditions. Biosiliceous productivity began increasing during the latter part of the YD, but it was only during the earliest Holocene (11.6 to 11.0 ka) that conditions similar to those of the B??lling-Allerod returned to the central Gulf. Between around 11.0 and 6.2 ka, tropical diatoms and silicoflagellates were virtually absent from the central Gulf, as relatively cooler and fresher surface waters resembling those of the modern northern Gulf were present in the central Gulf. Beginning at about 6.2 ka, tropical diatoms and silicoflagellates began increasing in the central Gulf, and coccoliths returned to western Gulf sediments. The onset of modern-day monsoon conditions in the American Southwest required the presence of warm SSTs in the northern Gulf, which probably did not occur until after about 5.4 ka, when tropical diatoms and silicoflagellates became relatively common in the central Gulf. Modern east-west contrasts, which arise from late winter-early spring coastal upwelling on the mainland side and lower diatom productivity on the western side of the Gulf, commenced between 6.2 and 5.4 ka, possibly due to a shift in the direction of late winter-early spring winds more towards the southeast, or down the axis of the Gulf. This proposed wind shift might have ultimately been due to a late Holocene strengthening of ENSO-like conditions

  9. Refrigeration a history

    CERN Document Server

    Gantz, Carroll

    2015-01-01

    For thousands of years, humans coped with heat by harvesting and storing natural ice and devising natural cooling systems that utilized ventilation and evaporation. By the mid 1800s, people began developing huge refrigeration machines to manufacture ice. By the early 1900s, engineers developed electric domestic refrigerators, which by 1927 were affordable convenient household appliances. By then, an increasingly sophisticated public demanded more modern-looking appliances than engineers could produce, and a new breed of designers entered the manufacturing world to provide them. During the Depr

  10. Robotics. Programmable self-assembly in a thousand-robot swarm.

    Science.gov (United States)

    Rubenstein, Michael; Cornejo, Alejandro; Nagpal, Radhika

    2014-08-15

    Self-assembly enables nature to build complex forms, from multicellular organisms to complex animal structures such as flocks of birds, through the interaction of vast numbers of limited and unreliable individuals. Creating this ability in engineered systems poses challenges in the design of both algorithms and physical systems that can operate at such scales. We report a system that demonstrates programmable self-assembly of complex two-dimensional shapes with a thousand-robot swarm. This was enabled by creating autonomous robots designed to operate in large groups and to cooperate through local interactions and by developing a collective algorithm for shape formation that is highly robust to the variability and error characteristic of large-scale decentralized systems. This work advances the aim of creating artificial swarms with the capabilities of natural ones. Copyright © 2014, American Association for the Advancement of Science.

  11. A microneedle array able to inject tens of thousands of cells simultaneously

    Science.gov (United States)

    Teichert, Gregory H.; Burnett, Sandra; Jensen, Brian D.

    2013-09-01

    This paper presents a biological microelectromechanical system for injecting foreign particles into thousands of cells simultaneously. The system inserts an array of microneedles into a monolayer of cells, and the foreign particles enter the cells by diffusion. The needle array is fabricated using a series of deep reactive ion etches and produces about 4 million needles that average 1 μm in diameter and 8 μm in length with 10 μm spacing. The insertion of the needles is controlled through a compliant suspension. The compliant suspension was designed to provide for needle motion into the cells while restraining rotations or transverse motions that could result in tearing of the cell membranes. Testing was performed using propidium iodide, a membrane impermeable dye, injected into HeLa cells. Average cell survivability was found to be 97.7%, and up to 97.9% of the surviving cells received the propidium iodide.

  12. A microneedle array able to inject tens of thousands of cells simultaneously

    International Nuclear Information System (INIS)

    Teichert, Gregory H; Jensen, Brian D; Burnett, Sandra

    2013-01-01

    This paper presents a biological microelectromechanical system for injecting foreign particles into thousands of cells simultaneously. The system inserts an array of microneedles into a monolayer of cells, and the foreign particles enter the cells by diffusion. The needle array is fabricated using a series of deep reactive ion etches and produces about 4 million needles that average 1 μm in diameter and 8 μm in length with 10 μm spacing. The insertion of the needles is controlled through a compliant suspension. The compliant suspension was designed to provide for needle motion into the cells while restraining rotations or transverse motions that could result in tearing of the cell membranes. Testing was performed using propidium iodide, a membrane impermeable dye, injected into HeLa cells. Average cell survivability was found to be 97.7%, and up to 97.9% of the surviving cells received the propidium iodide. (paper)

  13. 3D DOCUMENTATION AND DATA MANAGEMENT IN THE DAZU THOUSAND-HAND BODHISATTVA STATUE IN CHINA

    Directory of Open Access Journals (Sweden)

    M. L. Hou

    2016-06-01

    Full Text Available Recently different types 3D data of many cultural heritage are collected, however, how to store and manage these data problem. This paper presents a new solution regarding cultural 3D information fine reconstruction and data management based on 3D modeling. These data were stored with the file system and database, which improved the efficiency of data retrieval; on this basis, hyper-fine 3D models of cultural relics were established. Fine 3D information model based on this method can be used for 3D statistics, virtual restoration and change detection, etc. It can provide a scientific basis for the field of conservation and restoration of cultural relics, but can also provide a reference for fine 3D reconstruction to be applied to other cultural relics. Finally, the Dazu Thousand-hand Bodhisattva has been taken as an example, which verified the feasibility and effectiveness of the program.

  14. The Subaltern Voice in A Thousand Splendid Suns by Khaled Khosseini

    Directory of Open Access Journals (Sweden)

    Soraya Soraya

    2015-11-01

    Full Text Available Life in Afghanistan puts female as the second sex and the victims of patriarchy. In the eye of Orientalism, women are the east. Thus, they can be colonized and suppressed (the subaltern. This study was designed to answer the question how was the voice of the subaltern being represented by the characters in the novel A Thousand Splendid Suns by Khaled Khosseini. Library research was applied in this study. Data were  analyzed using postcolonial theory, specifically from Gayatri Spivak. The conclusion presents that both characters, Mariam and Laila is the representation of the subaltern who created voice to fight against the oppression. Between Mariam, the symbol of traditional woman, and Laila, the symbol of modern woman, only Laila who can reach the freedom. However, it is impossible to achieve without the courage and sacrifice of Mariam 

  15. Gender Discrimination in Orhan Pamuk's 'Snow' and Khaled Hosseini's 'A Thousand Splendid Suns'

    Directory of Open Access Journals (Sweden)

    Iis Sugianti

    2018-03-01

    Full Text Available Women's life without discrimination or violence is the freedom and entitlement of women's rights. The objective of the study is to achieve the idea. Dealing with it, the researcher applies feminism approach proposed by Damewood's theory of gender discrimination. Gender discrimination refers to the practice of granting or denying rights or privilege to a person based on his/her gender that is longstanding and acceptable to both genders. The novel `Snow` and `A Thousand Splendid Suns` focus on gender discrimination, violence, oppression, and struggle to fight against them. The researcher explores how gender discrimination, patriarchy culture and most of violence and oppression happened in family and country. The phenomenon of violence is not only a discrimination done by husbands who do gender discrimination in family, but also a fight done by a wife to fight against them, it depends on its case. In `Snow`, the women character faced many problems related to their headscarves. They are discriminated by their government and parents. Kadife is depicted as a brave woman. She tries to defend women‟s right in Kars to keep on using their headscarves. While in A `Thousand Splendid Suns`, the limitation of women`s activity happened. Women are banned to get education and they should stay at home. Mariam and Laila get oppression and violence by their husband. Their struggle is shown in the murder of their husband, Rasheed. The unstable practice of gender discrimination was continuously preserved by the culture, not religion. It was like a patriarchal culture that is one of clear examples of the women phenomena in the world and it can be in the form of prohibition and limitation of the role of women in the public area.

  16. An exponential growth of computational phantom research in radiation protection, imaging, and radiotherapy: a review of the fifty-year history.

    Science.gov (United States)

    Xu, X George

    2014-09-21

    Radiation dose calculation using models of the human anatomy has been a subject of great interest to radiation protection, medical imaging, and radiotherapy. However, early pioneers of this field did not foresee the exponential growth of research activity as observed today. This review article walks the reader through the history of the research and development in this field of study which started some 50 years ago. This review identifies a clear progression of computational phantom complexity which can be denoted by three distinct generations. The first generation of stylized phantoms, representing a grouping of less than dozen models, was initially developed in the 1960s at Oak Ridge National Laboratory to calculate internal doses from nuclear medicine procedures. Despite their anatomical simplicity, these computational phantoms were the best tools available at the time for internal/external dosimetry, image evaluation, and treatment dose evaluations. A second generation of a large number of voxelized phantoms arose rapidly in the late 1980s as a result of the increased availability of tomographic medical imaging and computers. Surprisingly, the last decade saw the emergence of the third generation of phantoms which are based on advanced geometries called boundary representation (BREP) in the form of Non-Uniform Rational B-Splines (NURBS) or polygonal meshes. This new class of phantoms now consists of over 287 models including those used for non-ionizing radiation applications. This review article aims to provide the reader with a general understanding of how the field of computational phantoms came about and the technical challenges it faced at different times. This goal is achieved by defining basic geometry modeling techniques and by analyzing selected phantoms in terms of geometrical features and dosimetric problems to be solved. The rich historical information is summarized in four tables that are aided by highlights in the text on how some of the most

  17. An exponential growth of computational phantom research in radiation protection, imaging, and radiotherapy: A review of the fifty-year history

    Science.gov (United States)

    Xu, X. George

    2014-01-01

    Radiation dose calculation using models of the human anatomy has been a subject of great interest to radiation protection, medical imaging, and radiotherapy. However, early pioneers of this field did not foresee the exponential growth of research activity as observed today. This review article walks the reader through the history of the research and development in this field of study which started some 50 years ago. This review identifies a clear progression of computational phantom complexity which can be denoted by three distinct generations. The first generation of stylized phantoms, representing a grouping of less than dozen models, was initially developed in the 1960s at Oak Ridge National Laboratory to calculate internal doses from nuclear medicine procedures. Despite their anatomical simplicity, these computational phantoms were the best tools available at the time for internal/external dosimetry, image evaluation, and treatment dose evaluations. A second generation of a large number of voxelized phantoms arose rapidly in the late 1980s as a result of the increased availability of tomographic medical imaging and computers. Surprisingly, the last decade saw the emergence of the third generation of phantoms which are based on advanced geometries called boundary representation (BREP) in the form of Non-Uniform Rational B-Splines (NURBS) or polygonal meshes. This new class of phantoms now consists of over 287 models including those used for non-ionizing radiation applications. This review article aims to provide the reader with a general understanding of how the field of computational phantoms came about and the technical challenges it faced at different times. This goal is achieved by defining basic geometry modeling techniques and by analyzing selected phantoms in terms of geometrical features and dosimetric problems to be solved. The rich historical information is summarized in four tables that are aided by highlights in the text on how some of the most well

  18. [History of Polish botanical and mycological researches on sheets of land of Antarctic and Sub-Antarctic in the years 1977-2009].

    Science.gov (United States)

    Köhler, Piotr; Olech, Maria

    2011-01-01

    The work includes a description of the period from the moment of setting up Polish Polar Station on King George Island (1977) to the end of International Polar Year IV in 2009. Researches on flower plants focused, among others, on plants' morphology, morphological composition of the pollen and anatomical ultra-structure of the leaves. There were also carried out biochemical and other searches for the internal mutability. Within physiological studies one concentrated on the problem of reaction to temperature stress. Biological researches focused mainly on solving taxonomic and bio-geographic problems. Finally, were published several monographs and, among others, the first in history complete description of moss' flora of the whole of Antarctic (2008). Research works over algae included also such issues as floristics, bio-geography, taxonomy and ecology (for instance, the rookery's impact on distribution of algae, or the influence of inanimate factors on dynamics of condensing the Diatoma in different water and soil-bound tanks). Up till now, within mycological investigations has been identified a variety of lichen fungi that for the most part of Antarctic are a novelty. There were scientifically described new for science genera and species of Western Antarctic. Lichenological studies were made in the field of taxonomy, geography, lichenometry, biochemistry of lichens, lichenoindication, ecophysiology and from the point of analysis of base metals' content. There were also described new for science species. Since 1991, were published the results of searches for the base metals' content and vestigial chemical elements in lichens' thallus. Ecophysiological researches concerned both micro-climatic conditions' impact on primary production and lichens' adaptation to a very cold climate. One discovered a mechanism of two-phase hydratization/dehydratization of lichens' thallus. On the ground of palaeobotanical analyzes was reconstructed a development of flora in Western

  19. Atmospheric Deposition History of Trace Metals and Metalloids for the Last 200 Years Recorded by Three Peat Cores in Great Hinggan Mountain, Northeast China

    Directory of Open Access Journals (Sweden)

    Kunshan Bao

    2015-03-01

    , even after the ban of leaded gasoline use in China. Emissions from coal and leaded gasoline combustions in northern China are regarded as one of the major sources of anthropogenic Pb input in this region; meanwhile, the long-distance transportation of Pb-bearing aerosols from Mongolia should be also taken into consideration. The reconstructed history of TMs’ pollution over the past ca. 200 years is in agreement with the industrial development in China and clearly illustrates the influence of human activities on local rural environments. This study shows the utility of taking multi-cores to show the heterogeneity in peat accumulation and applying PCA, EF and Pb isotope methods in multi-proxies analyses for establishing a high resolution geochemical metal record from peatland.

  20. 60 Years of Southwestern Archaeology, A History of the Pecos Conference, by Richard B. Woodbury, University of New Mexico Press, Albuquerque, 1993.

    Directory of Open Access Journals (Sweden)

    Jonathan E. Reyman

    1993-11-01

    Full Text Available Among the least commendable characteristics of the New Archaeology is a marked anti-historical perspective. The history of archaeology and much, if not most, of earlier theory, method, and the results of fieldwork are considered not worth knowing or irrelevant, especially for graduate education: "graduate courses in anthropology should cease being histories of thought" (Schiffer 1976:193. Regrettably, New Archaeologists generally adopted this perspective and attitude, and partly because they did not pay attention to the history of archaeology, they tended to confirm Santayana's "hypothesis" about the consequences of forgetting the past: many of the arguments and accompanying rancor in the current debate between New Archaeologists and Post-Processualists resound the confrontation of a quarter century ago between New Archaeologists - "the louts" as Florence Hawley Ellis called them (p. 307, this volume and their predecessors. Furthermore, because the antihistorical bias became so widely adopted, it was difficult to publish on the history of archaeology, at least in the United States.

  1. Role of adiposity and lifestyle in the relationship between family history of diabetes and 20-year incidence of type 2 diabetes in US women

    NARCIS (Netherlands)

    van 't Riet, E.; Dekker, J.M.; Sun, Q.; Nijpels, G.; Hu, F.B.; van Dam, R.M.

    2010-01-01

    OBJECTIVE - To evaluate to what extent the association between family history of diabetes and risk of type 2 diabetes can be explained by excess adiposity and lifestyle risk factors. RESEARCH DESIGN AND METHODS - We analyzed data from 73,227 women who participated in the Nurses' Health Study cohort.

  2. Entangled histories

    International Nuclear Information System (INIS)

    Cotler, Jordan; Wilczek, Frank

    2016-01-01

    We introduce quantum history states and their mathematical framework, thereby reinterpreting and extending the consistent histories approach to quantum theory. Through thought experiments, we demonstrate that our formalism allows us to analyze a quantum version of history in which we reconstruct the past by observations. In particular, we can pass from measurements to inferences about ‘what happened’ in a way that is sensible and free of paradox. Our framework allows for a richer understanding of the temporal structure of quantum theory, and we construct history states that embody peculiar, non-classical correlations in time. (paper)

  3. Population structure of Geosmithia morbida, the causal agent of thousand cankers disease of walnut trees in the United States

    Science.gov (United States)

    Marcelo M. Zerillo; Jorge Ibarra Caballero; Keith Woeste; Andrew D. Graves; Colleen Hartel; Jay W. Pscheidt; Jadelys Tonos; Kirk Broders; Whitney Cranshaw; Steven J. Seybold; Ned Tisserat

    2014-01-01

    The ascomycete Geosmithia morbida and the walnut twig beetle Pityophthorus juglandis are associated with thousand cankers disease of Juglans (walnut) and Pterocarya (wingnut). The disease was first reported in the western United States (USA) on several Juglans species, but...

  4. Conceptual History, Cultural History, Social History

    Directory of Open Access Journals (Sweden)

    Viktor Zhivov (†

    2014-10-01

    Full Text Available V. M. Zhivov’s introduction to Studies in Historical Semantics of the Russian Language in the Early Modern Period (2009, translated here for the first time, offers a critical survey of the historiography on Begriffsgeschichte, the German school of conceptual history associated with the work of Reinhart Koselleck, as well as of its application to the study of Russian culture.  By situating Begriffsgeschichte in the context of late-nineteenth and early twentieth-century European philosophy, particularly hermeneutics and phenomenology, the author points out the important, and as yet unacknowledged, role that Russian linguists have played in the development of a native school of conceptual history.  In the process of outlining this alternative history of the discipline, Zhivov provides some specific examples of the way in which the study of “historical semantics” can be used to analyze the development of Russian modernity.

  5. The History of Secondary Education in History of Education

    Science.gov (United States)

    McCulloch, Gary

    2012-01-01

    "History of Education" has published a steady stream of papers on the history of secondary education over the first 40 years of its existence. This corpus of research has been generated in the context of renewed interest in the history of secondary education that has been stimulated by developments in social and historical inquiry as…

  6. Intellectual History

    DEFF Research Database (Denmark)

    In the 5 Questions book series, this volume presents a range of leading scholars in Intellectual History and the History of Ideas through their answers to a brief questionnaire. Respondents include Michael Friedman, Jacques le Goff, Hans Ulrich Gumbrecht, Jonathan Israel, Phiip Pettit, John Pocock...

  7. Mud Volcanoes - Analogs to Martian Cones and Domes (by the thousands !)

    Science.gov (United States)

    Allen, C.; Oehler, D.

    2010-12-01

    Mud volcanoes are mounds formed by low temperature slurries of gas, liquid, sediments and rock that erupt to the surface from depths of meters to kilometers. They are common on Earth, with estimates of thousands onshore and tens of thousands offshore. Mud volcanoes occur in basins with rapidly-deposited accumulations of fine-grained sediments. Such settings are ideal for concentration and preservation of organic materials, and mud volcanoes typically occur in sedimentary basins that are rich in organic biosignatures. Domes and cones, cited as possible mud volcanoes by previous authors, are common on the northern plains of Mars. Our analysis of selected regions in southern Acidalia Planitia has revealed over 18,000 such features, and we estimate that more than 40,000 occur across the area. These domes and cones strongly resemble terrestrial mud volcanoes in size, shape, morphology, associated flow structures and geologic setting. Geologic and mineralogic arguments rule out alternative formation mechanisms involving lava, ice and impacts. We are studying terrestrial mud volcanoes from onshore and submarine locations. The largest concentration of onshore features is in Azerbaijan, near the western edge of the Caspian Sea. These features are typically hundreds of meters to several kilometers in diameter, and tens to hundreds of meters in height. Satellite images show spatial densities of 20 to 40 eruptive centers per 1000 km2. Many of the features remain active, and fresh mud flows as long as several kilometers are common. A large field of submarine mud volcanoes is located in the Gulf of Cadiz, off the Atlantic coasts of Morocco and Spain. High-resolution sonar bathymetry reveals numerous km-scale mud volcanoes, hundreds of meters in height. Seismic profiles demonstrate that the mud erupts from depths of several hundred meters. These submarine mud volcanoes are the closest morphologic analogs yet found to the features in Acidalia Planitia. We are also conducting

  8. Mud Volcanoes - Analogs to Martian Cones and Domes (by the Thousands!)

    Science.gov (United States)

    Allen, Carlton C.; Oehler, Dorothy

    2010-01-01

    Mud volcanoes are mounds formed by low temperature slurries of gas, liquid, sediments and rock that erupt to the surface from depths of meters to kilometers. They are common on Earth, with estimates of thousands onshore and tens of thousands offshore. Mud volcanoes occur in basins with rapidly-deposited accumulations of fine-grained sediments. Such settings are ideal for concentration and preservation of organic materials, and mud volcanoes typically occur in sedimentary basins that are rich in organic biosignatures. Domes and cones, cited as possible mud volcanoes by previous authors, are common on the northern plains of Mars. Our analysis of selected regions in southern Acidalia Planitia has revealed over 18,000 such features, and we estimate that more than 40,000 occur across the area. These domes and cones strongly resemble terrestrial mud volcanoes in size, shape, morphology, associated flow structures and geologic setting. Geologic and mineralogic arguments rule out alternative formation mechanisms involving lava, ice and impacts. We are studying terrestrial mud volcanoes from onshore and submarine locations. The largest concentration of onshore features is in Azerbaijan, near the western edge of the Caspian Sea. These features are typically hundreds of meters to several kilometers in diameter, and tens to hundreds of meters in height. Satellite images show spatial densities of 20 to 40 eruptive centers per 1000 square km. Many of the features remain active, and fresh mud flows as long as several kilometers are common. A large field of submarine mud volcanoes is located in the Gulf of Cadiz, off the Atlantic coasts of Morocco and Spain. High-resolution sonar bathymetry reveals numerous km-scale mud volcanoes, hundreds of meters in height. Seismic profiles demonstrate that the mud erupts from depths of several hundred meters. These submarine mud volcanoes are the closest morphologic analogs yet found to the features in Acidalia Planitia. We are also conducting

  9. Indications for and pregnancy outcomes of cervical cerclage: 11-year comparison of patients undergoing history-indicated, ultrasound-indicated, or rescue cerclage.

    Science.gov (United States)

    Chan, Lucia L K; Leung, T W; Lo, T K; Lau, W L; Leung, W C

    2015-08-01

    To review and compare pregnancy outcomes of patients undergoing history-indicated, ultrasound-indicated, or rescue cerclage. Case series with internal comparison. A regional obstetric unit in Hong Kong. Women undergoing cervical cerclage at Kwong Wah Hospital between 1 January 2001 and 31 December 2011. Cervical cerclage. Pregnancy outcomes including miscarriage, gestational age at delivery, birth weight, and duration of pregnancy prolongation. Overall, 47 patients were included. Nine (19.1%) pregnancies resulted in miscarriage. The median gestational age at delivery was 35.7 weeks. Among the 23 patients who had history-indicated cerclage, only four (17.4%) had three or more previous second-trimester miscarriages or preterm deliveries. Among the 15 patients who had ultrasound-indicated cerclage, preoperative cervical length of ≤1.5 cm was associated with shorter prolongation of pregnancy, compared with that of >1.5 cm (median, 12.1 vs 18.4 weeks; P=0.009). Among the nine women who had rescue cerclage, those who underwent the procedure before 20 weeks of gestation delivered earlier than those underwent cerclage later (median, 22.5 vs 34.1 weeks; P=0.048). Patients eligible for the Royal College of Obstetricians and Gynaecologists-recommended history-indicated cerclage remain few. The majority of patients may benefit from serial ultrasound monitoring of cervical length with or without ultrasound-indicated cerclage.

  10. Transcription Factors Bind Thousands of Active and InactiveRegions in the Drosophila Blastoderm

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xiao-Yong; MacArthur, Stewart; Bourgon, Richard; Nix, David; Pollard, Daniel A.; Iyer, Venky N.; Hechmer, Aaron; Simirenko, Lisa; Stapleton, Mark; Luengo Hendriks, Cris L.; Chu, Hou Cheng; Ogawa, Nobuo; Inwood, William; Sementchenko, Victor; Beaton, Amy; Weiszmann, Richard; Celniker, Susan E.; Knowles, David W.; Gingeras, Tom; Speed, Terence P.; Eisen, Michael B.; Biggin, Mark D.

    2008-01-10

    Identifying the genomic regions bound by sequence-specific regulatory factors is central both to deciphering the complex DNA cis-regulatory code that controls transcription in metazoans and to determining the range of genes that shape animal morphogenesis. Here, we use whole-genome tiling arrays to map sequences bound in Drosophila melanogaster embryos by the six maternal and gap transcription factors that initiate anterior-posterior patterning. We find that these sequence-specific DNA binding proteins bind with quantitatively different specificities to highly overlapping sets of several thousand genomic regions in blastoderm embryos. Specific high- and moderate-affinity in vitro recognition sequences for each factor are enriched in bound regions. This enrichment, however, is not sufficient to explain the pattern of binding in vivo and varies in a context-dependent manner, demonstrating that higher-order rules must govern targeting of transcription factors. The more highly bound regions include all of the over forty well-characterized enhancers known to respond to these factors as well as several hundred putative new cis-regulatory modules clustered near developmental regulators and other genes with patterned expression at this stage of embryogenesis. The new targets include most of the microRNAs (miRNAs) transcribed in the blastoderm, as well as all major zygotically transcribed dorsal-ventral patterning genes, whose expression we show to be quantitatively modulated by anterior-posterior factors. In addition to these highly bound regions, there are several thousand regions that are reproducibly bound at lower levels. However, these poorly bound regions are, collectively, far more distant from genes transcribed in the blastoderm than highly bound regions; are preferentially found in protein-coding sequences; and are less conserved than highly bound regions. Together these observations suggest that many of these poorly-bound regions are not involved in early

  11. The Anthropocene era. The Earth, the history and us

    International Nuclear Information System (INIS)

    Bonneuil, Christophe; Fressoz, Jean-Baptiste

    2013-01-01

    As some scientists state that the Earth entered the Anthropocene era which is an anthropogenic geological revolution: the traces of our urban, consumption, chemical and nuclear era will remain in the planet geological archives for thousands and even millions of years, and will result in huge difficulties for human societies. Between science and history, the authors give an overview of a development model which has become unsustainable: studies which highlighted the impossibility of an indefinite growth in the 1970's have been ignored, and instead of taking the three dimensions involved in sustainable development (economy, social, environment), into account, environment tends to become only a new item in firm accounting (markets of eco-systemic services, the biosphere, hydrosphere and atmosphere about to become simple subsystems of the financial and merchandising sphere)

  12. A genomic history of Aboriginal Australia

    KAUST Repository

    Malaspinas, Anna-Sapfo

    2016-09-20

    The population history of Aboriginal Australians remains largely uncharacterized. Here we generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama-Nyungan languages) and 25 Papuans from the New Guinea Highlands. We find that Papuan and Aboriginal Australian ancestors diversified 25-40 thousand years ago (kya), suggesting pre-Holocene population structure in the ancient continent of Sahul (Australia, New Guinea and Tasmania). However, all of the studied Aboriginal Australians descend from a single founding population that differentiated ∼10-32 kya. We infer a population expansion in northeast Australia during the Holocene epoch (past 10,000 years) associated with limited gene flow from this region to the rest of Australia, consistent with the spread of the Pama-Nyungan languages. We estimate that Aboriginal Australians and Papuans diverged from Eurasians 51-72 kya, following a single out-of-Africa dispersal, and subsequently admixed with archaic populations. Finally, we report evidence of selection in Aboriginal Australians potentially associated with living in the desert. © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved

  13. Evolving T-cell vaccine strategies for HIV, the virus with a thousand faces

    Energy Technology Data Exchange (ETDEWEB)

    Korber, Bette [Los Alamos National Laboratory

    2009-01-01

    HIV's rapid global spread and the human suffering it has left in its wake have made AIDS a global heath priority for the 25 years since its discovery. Yet its capacity to rapidly evolve has made combating this virus a tremendous challenge. The obstacles to creating an effective HIV vaccine are formidable, but there are advances in the field on many fronts, in terms of novel vectors, adjuvants, and antigen design strategies. SIV live attenuated vaccine models are able to confer protection against heterologous challenge, and this continues to provide opportunities to explore the biological underpinnings of a protective effect (9). More indirect, but equally important, is new understanding regarding the biology of acute infection (43), the role of immune response in long-term non-progression (6,62, 81), and defining characteristics of broadly neutralizing antibodies (4). In this review we will focus on summarizing strategies directed towards a single issue, that of contending with HIV variation in terms of designing aT-cell vaccine. The strategies that prove most effective in this area can ultimately be combined with the best strategies under development in other areas, with the hope of ultimately converging on a viable vaccine candidate. Only two large HIV vaccine efficacy trials have been completed and both have failed to prevent infection or confer a benefit to infected individual (23,34), but there is ample reason to continue our efforts. A historic breakthrough came in 1996, when it was realized that although the virus could escape from a single antiretroviral (ARV) therapy, it could be thwarted by a combination of medications that simultaneously targeted different parts of the virus (HAART) (38). This revelation came after 15 years of research, thought, and clinical testing; to enable that vital progress the research and clinical communities had to first define and understand, then develop a strategy to counter, the remarkable evolutionary potential of the

  14. Portraying User Interface History

    DEFF Research Database (Denmark)

    Jørgensen, Anker Helms

    2008-01-01

    The user interface is coming of age. Papers adressing UI history have appeared in fair amounts in the last 25 years. Most of them address particular aspects such as an in­novative interface paradigm or the contribution of a visionary or a research lab. Contrasting this, papers addres­sing UI...... history at large have been sparse. However, a small spate of publications appeared recently, so a reasonable number of papers are available. Hence this work-in-progress paints a portrait of the current history of user interfaces at large. The paper first describes a theoretical framework recruited from...... history. Next the paper analyses a selected sample of papers on UI history at large. The analysis shows that the current state-of-art is featured by three aspects: Firstly internalism, in that the papers adress the tech­nologies in their own right with little con­text­ualization, secondly whiggism...

  15. SWAP-Assembler: scalable and efficient genome assembly towards thousands of cores.

    Science.gov (United States)

    Meng, Jintao; Wang, Bingqiang; Wei, Yanjie; Feng, Shengzhong; Balaji, Pavan

    2014-01-01

    There is a widening gap between the throughput of massive parallel sequencing machines and the ability to analyze these sequencing data. Traditional assembly methods requiring long execution time and large amount of memory on a single workstation limit their use on these massive data. This paper presents a highly scalable assembler named as SWAP-Assembler for processing massive sequencing data using thousands of cores, where SWAP is an acronym for Small World Asynchronous Parallel model. In the paper, a mathematical description of multi-step bi-directed graph (MSG) is provided to resolve the computational interdependence on merging edges, and a highly scalable computational framework for SWAP is developed to automatically preform the parallel computation of all operations. Graph cleaning and contig extension are also included for generating contigs with high quality. Experimental results show that SWAP-Assembler scales up to 2048 cores on Yanhuang dataset using only 26 minutes, which is better than several other parallel assemblers, such as ABySS, Ray, and PASHA. Results also show that SWAP-Assembler can generate high quality contigs with good N50 size and low error rate, especially it generated the longest N50 contig sizes for Fish and Yanhuang datasets. In this paper, we presented a highly scalable and efficient genome assembly software, SWAP-Assembler. Compared with several other assemblers, it showed very good performance in terms of scalability and contig quality. This software is available at: https://sourceforge.net/projects/swapassembler.

  16. Jupiter’s atmospheric jet streams extend thousands of kilometres deep

    Science.gov (United States)

    Kaspi, Y.; Galanti, E.; Hubbard, W. B.; Stevenson, D. J.; Bolton, S. J.; Iess, L.; Guillot, T.; Bloxham, J.; Connerney, J. E. P.; Cao, H.; Durante, D.; Folkner, W. M.; Helled, R.; Ingersoll, A. P.; Levin, S. M.; Lunine, J. I.; Miguel, Y.; Militzer, B.; Parisi, M.; Wahl, S. M.

    2018-03-01

    The depth to which Jupiter’s observed east–west jet streams extend has been a long-standing question. Resolving this puzzle has been a primary goal for the Juno spacecraft, which has been in orbit around the gas giant since July 2016. Juno’s gravitational measurements have revealed that Jupiter’s gravitational field is north–south asymmetric, which is a signature of the planet’s atmospheric and interior flows. Here we report that the measured odd gravitational harmonics J3, J5, J7 and J9 indicate that the observed jet streams, as they appear at the cloud level, extend down to depths of thousands of kilometres beneath the cloud level, probably to the region of magnetic dissipation at a depth of about 3,000  kilometres. By inverting the measured gravity values into a wind field, we calculate the most likely vertical profile of the deep atmospheric and interior flow, and the latitudinal dependence of its depth. Furthermore, the even gravity harmonics J8 and J10 resulting from this flow profile also match the measurements, when taking into account the contribution of the interior structure. These results indicate that the mass of the dynamical atmosphere is about one per cent of Jupiter’s total mass.

  17. THE STUDY OF SIMPLIFICATION AND EXPLICITATION TECHNIQUES IN KHALED HOSSEINI'S “A THOUSAND SPLENDID SUNS”

    Directory of Open Access Journals (Sweden)

    Reza Kafipour

    2016-12-01

    Full Text Available Teaching and learning strategies help facilitate teaching and learning. Among them, simplification and explicitation strategies are those which help transferring the meaning to the learners and readers of a translated text. The aim of this study was to investigate explicitation and simplification in Persian translation of novel of Khaled Hosseini's “A Thousand Splendid Suns”. The study also attempted to find out frequencies of simplification and explicitation techniques used by the translators in translating the novel. To do so, 359 sentences out of 6000 sentences in original text were selected by systematic random sampling procedure. Then the percentage and total sums of each one of the strategies were calculated. The result showed that both translators used simplification and explicitation techniques significantly in their translation whereas Saadvandian, the first translator, significantly applied more simplification techniques in comparison with Ghabrai, the second translator. However, no significant difference was found between translators in the application of explicitation techniques. The study implies that these two translation strategies were fully familiar for the translators as both translators used them significantly to make the translation more understandable to the readers.

  18. The development of laser-plasma interaction program LAP3D on thousands of processors

    Directory of Open Access Journals (Sweden)

    Xiaoyan Hu

    2015-08-01

    Full Text Available Modeling laser-plasma interaction (LPI processes in real-size experiments scale is recognized as a challenging task. For explorering the influence of various instabilities in LPI processes, a three-dimensional laser and plasma code (LAP3D has been developed, which includes filamentation, stimulated Brillouin backscattering (SBS, stimulated Raman backscattering (SRS, non-local heat transport and plasmas flow computation modules. In this program, a second-order upwind scheme is applied to solve the plasma equations which are represented by an Euler fluid model. Operator splitting method is used for solving the equations of the light wave propagation, where the Fast Fourier translation (FFT is applied to compute the diffraction operator and the coordinate translations is used to solve the acoustic wave equation. The coupled terms of the different physics processes are computed by the second-order interpolations algorithm. In order to simulate the LPI processes in massively parallel computers well, several parallel techniques are used, such as the coupled parallel algorithm of FFT and fluid numerical computation, the load balance algorithm, and the data transfer algorithm. Now the phenomena of filamentation, SBS and SRS have been studied in low-density plasma successfully with LAP3D. Scalability of the program is demonstrated with a parallel efficiency above 50% on about ten thousand of processors.

  19. A Sociolinguistic Study of Fagunwa/Soyinka’s The Forest of a Thousand Daemons

    Directory of Open Access Journals (Sweden)

    Idowu Odebode

    2012-09-01

    Full Text Available This study takes a sociolinguistic approach to analyze The Forest of a Thousand Daemons, a translation of the Yoruba text, Ogboju Ode Ninu Igbo Irunmale (1938 which was authored by Daniel Olorunfemi Fagunwa, the greatest Yoruba novelist and translated by Wole Soyinka, a literary icon cum Nobel laureate. The work is premised on the fact that many literary and linguistic attempts at Fagunwa’s work have failed to benchmark the text with the speech act theory and the VARIES model simultaneously as we have done in this study. Fifteen excerpts from the text served as our data. Each datum is subjected to content and quantitative analyses based on relevant sociolinguistic variables of vocation (occupation, sex, age, religion, geography (ethnicity, age, education and socio-economic status. The data were further dissected according to the speech act theory by Austin (1962 in a bid to ascertain the validity of their illocutionary force(s. The study indicates that social institutions affect language (choice and use a great deal and language, in turn, performs different illocutionary acts among various heterogeneous social groups in a speech community like the Yoruba, which is replicated in the text.

  20. Genomics and introgression: discovery and mapping of thousands of species-diagnostic SNPs using RAD sequencing

    Science.gov (United States)

    Hand, Brian K.; Hether, Tyler D; Kovach, Ryan P.; Muhlfeld, Clint C.; Amish, Stephen J.; Boyer, Matthew C.; O’Rourke, Sean M.; Miller, Michael R.; Lowe, Winsor H.; Hohenlohe, Paul A.; Luikart, Gordon

    2015-01-01

    Invasive hybridization and introgression pose a serious threat to the persistence of many native species. Understanding the effects of hybridization on native populations (e.g., fitness consequences) requires numerous species-diagnostic loci distributed genome-wide. Here we used RAD sequencing to discover thousands of single-nucleotide polymorphisms (SNPs) that are diagnostic between rainbow trout (RBT, Oncorhynchus mykiss), the world’s most widely introduced fish, and native westslope cutthroat trout (WCT, O. clarkii lewisi) in the northern Rocky Mountains, USA. We advanced previous work that identified 4,914 species-diagnostic loci by using longer sequence reads (100 bp vs. 60 bp) and a larger set of individuals (n = 84). We sequenced RAD libraries for individuals from diverse sampling sources, including native populations of WCT and hatchery broodstocks of WCT and RBT. We also took advantage of a newly released reference genome assembly for RBT to align our RAD loci. In total, we discovered 16,788 putatively diagnostic SNPs, 10,267 of which we mapped to anchored chromosome locations on the RBT genome. A small portion of previously discovered putative diagnostic loci (325 of 4,914) were no longer diagnostic (i.e., fixed between species) based on our wider survey of non-hybridized RBT and WCT individuals. Our study suggests that RAD loci mapped to a draft genome assembly could provide the marker density required to identify genes and chromosomal regions influencing selection in admixed populations of conservation concern and evolutionary interest.

  1. Human radiation studies: Remembering the early years: Oral history of radiation biologist Marvin Goldman, Ph.D., conducted December 22, 1994

    International Nuclear Information System (INIS)

    1995-09-01

    This report provides a transcript of an interview of Dr. Marvin Goldman by representatives of DOE's Office of Human Radiation Experiments. Dr. Goldman was chosen for this interview because of his work on bone-seeking radionuclides. After a brief biographical sketch Dr. Goldman related his experiences concerning his training and work at Rochester University, his work at Brookhaven National Laboratory, his participation in the Beagle Studies at University of California at Davis, his work with the Chernobyl Nuclear Plant Accident, his consultation work with Russian authorities on the health and ecological effects in their history, and finally his opinions and recommendations on human radiation research and the environmental cleanup of DOE sites

  2. Squamous cell carcinoma of the oral cavity and oropharynx in patients aged 18-45 years: A case-control study to evaluate the risk factors with emphasis on stress, diet, oral hygiene, and family history.

    Science.gov (United States)

    Dholam, K P; Chouksey, G C

    2016-01-01

    Increasing incidence of squamous cell carcinoma (SCC) of the oral cavity and oropharynx is reported in young adults. However, there is a paucity regarding etiology and risk factors. To evaluate the exposure potential carcinogenic factors among a sample aged 45 years and younger, diagnosed with SCC of the oral cavity and oropharynx. Eighty-five case samples aged 18-45 years, diagnosed with SCC of the oral cavity and oropharynx were compared with 85 controls who had never had cancer, matched for age and sex. This study was conducted by questionnaire-based interviews. Questionnaire contained items about exposure to the following risk factors: Caries prevalence, oral hygiene status, dental trauma, dental visit, stress, family history of cancer, environmental exposure to potential carcinogens, diet, body mass index (BMI), habits such as smoking, tobacco chewing, betel quid/pan, or supari. Odds ratios (ORs) of oral and pharyngeal cancer and the corresponding 95% confidence intervals were estimated using multiple logistic regression models. Pstress, dental trauma, low BMI, family history of cancer, exposure to environmental carcinogens, and habit of placement of quid for 11-20 years. An increased risk of oral and pharyngeal cancer was seen in cases who had poor oral hygiene, stress, dental trauma, low BMI, family history of cancer, exposure to environmental carcinogens, and habit of placement of quid.

  3. Family History

    Science.gov (United States)

    Your family history includes health information about you and your close relatives. Families have many factors in common, including their genes, ... as heart disease, stroke, and cancer. Having a family member with a disease raises your risk, but ...

  4. Paranthropus boisei: fifty years of evidence and analysis.

    Science.gov (United States)

    Wood, Bernard; Constantino, Paul

    2007-01-01

    Paranthropus boisei is a hominin taxon with a distinctive cranial and dental morphology. Its hypodigm has been recovered from sites with good stratigraphic and chronological control, and for some morphological regions, such as the mandible and the mandibular dentition, the samples are not only relatively well dated, but they are, by paleontological standards, reasonably-sized. This means that researchers can trace the evolution of metric and nonmetric variables across hundreds of thousands of years. This paper is a detailed review of half a century's worth of fossil evidence and analysis of P. boisei and traces how both its evolutionary history and our understanding of its evolutionary history have evolved during the past 50 years. (c) 2007 Wiley-Liss, Inc.

  5. Geochemistry of waters in the Valley of Ten Thousand Smokes region, Alaska

    Science.gov (United States)

    Keith, T.E.C.; Thompson, J.M.; Hutchinson, R.A.; White, L.D.

    1992-01-01

    Meteoric waters from cold springs and streams outside of the 1912 eruptive deposits filling the Valley of Ten Thousand Smokes (VTTS) and in the upper parts of the two major rivers draining the 1912 deposits have similar chemical trends. Thermal springs issue in the mid-valley area along a 300-m lateral section of ash-flow tuff, and range in temperature from 21 to 29.8??C in early summer and from 15 to 17??C in mid-summer. Concentrations of major and minor chemical constituents in the thermal waters are nearly identical regardless of temperature. Waters in the downvalley parts of the rivers draining the 1912 deposits are mainly mixtures of cold meteoric waters and thermal waters of which the mid-valley thermal spring waters are representative. The weathering reactions of cold waters with the 1912 deposits appear to have stabilized and add only subordinate amounts of chemical constituents to the rivers relative to those contributed by the thermal waters. Isotopic data indicate that the mid-valley thermal spring waters are meteoric, but data is inconclusive regarding the heat source. The thermal waters could be either from a shallow part of a hydrothermal system beneath the 1912 vent region or from an incompletely cooled, welded tuff lens deep in the 1912 ash-flow sheet of the upper River Lethe area. Bicarbonate-sulfate waters resulting from interaction of near-surface waters and the cooling 1953-1968 southwest Trident plug issue from thermal springs south of Katmai Pass and near Mageik Creek, although the Mageik Creek spring waters are from a well-established, more deeply circulating hydrothermal system. Katmai caldera lake waters are a result of acid gases from vigorous drowned fumaroles dissolving in lake waters composed of snowmelt and precipitation. ?? 1992.

  6. The valley of ten thousand Smokes, Katmai, Klaska: A unique geochemistry laboratory

    Science.gov (United States)

    Papike, J. J.

    1992-04-01

    During June 6-8, 1912, a new vent (Novarupta) near Mt. Katmai in the Aleutian Range of Alaska released the largest volcanic eruption of this century and the largest rhyolitic eruption in nearly twenty centuries. Spectacular fumaroles developed in the ash-flow sheet prompting Robert F. Griggs, who discovered the steaming valley in 1916, to name it the Valley of Ten Thousand Smokes (VTTS). The Katmai Scientific Drilling Project was developed to advance understanding of the physical and chemical processes involved with explosive volcanism, through an interdisciplinary investigation of the Novarupta Vent and fissure fumaroles present in the ash-flow sheet. Novarupta Vent represents a unique target for subsurface geophysical and coring studies of structures and lithologies produced by explosive volcanism ( PANEL ON VOLCANIC STUDIES AT KATMAI, National Academy of Sciences, 1989). Scientific expeditions sponsored by the Department of Energy, the National Science Foundation, and the U.S. Geological Survey were conducted during the summers of 1989 and 1990. Most of the surface studies are now complete and drilling is planned for 1994, contingent on successful completion of the National Environmental Policy Act process. One of the main objectives of this ambitious study is to determine the source, mechanisms, and thermal and chemical conditions of the fumarolic transport of elements that occurred following ash-flow emplacement. As part of the surface investigation, prior to drilling, a detailed geochemical study has been initiated involving the mass flux of nearly fifty major, minor, and trace elements using samples from fumarolic deposits located in distal (rhyolitic) and proximal (dacitic and andesitic) portions of the ash-flow sheet. Significant enrichments are observed in S, Br, Cl, F, Zn, Pb, Cu, Sn, Cr, Ni, As, Sb and Au in various portions of the fossil fumaroles. These enrichments correlate well with those determined in active, high-temperature fumarolic sublimates

  7. School of History

    Directory of Open Access Journals (Sweden)

    V. I. Ukolova

    2014-01-01

    Full Text Available The current international processes and events, world politics at the beginning of the 21 century have once again clearly demonstrated that their meaning often emerges through the historical context without which the understanding of what is happening is hardly possible. Rector of MGIMO A.V. Torkunov in his talk on International relations as an educational discipline remarked that "as for sciences the basis of professionalism is mathematical skills and competencies, for international relations such a basis is history". Historical disciplines are taught at MGIMO from the very start of education process. MGIMO is one of the leading centers of research in the fields of history, political sciences and humanities. Here, in different years academics E.V. Tarle, L.N. Ivanov, V.G. Trukhanovskiy, A.L. Narochnitskiy and other prominent scholars and historians taught. Historical School of MGIMO has united important areas of historical science: the history of political processes in the twentieth century, modern history, the history of international relations and diplomacy, historical regional studies and cultural studies, oriental, philosophy and theory of history. The best traditions of the MGIMO historical school incorporated by its founders, make the foundation of its development at present. In 1992, the Department of MGIMO world and national history was established. The principle innovation was the combination of two components - historical education and historical science. This made it possible to present the story of Russia as an important part of the world history, opened up prospects for the implementation of comparative history, the synthesis of specific historical approaches and generalized global vision of civilization and human development. The historical school has realised a number of research projects, including "Alexander Nevsky" and the multi-volume "Great Victory", the work continues on a research project "Russia in the Modern World", and

  8. The exhibition Namibia-Germany: a shared/divided history. Resistance, violence, memory

    Directory of Open Access Journals (Sweden)

    Clara Himmelheber

    2014-10-01

    Full Text Available The year 2004 was the centenary of the outbreak of a colonial war in former German South West Africa in which thousands of Africans were killed by the colonial power. Although of crucial importance for Namibia, the war had not entered public memory in Germany. The exhibition aimed at presenting colonial history, as well as the contemporary relationships between the two countries, showing a ‘shared’ and a ‘divided’ history. The exhibition created a public debate, which certainly supported the initiative of the German Minister of Economic Co-operation and Development to deliver an apology at the commemoration in August 2004 in Namibia. The article is a post-reflection of one of the co-curators on the exhibition putting it into a larger context and reviewing it concurrently.

  9. Sea-level rise and landscape change influence mangrove encroachment onto marsh in the Ten Thousand Islands region of Florida, USA

    Science.gov (United States)

    Krauss, Ken W.; From, Andrew S.; Doyle, Thomas W.; Doyle, Terry J.; Barry, Michael J.

    2011-01-01

    The Ten Thousand Islands region of southwestern Florida, USA is a major feeding and resting destination for breeding, migrating, and wintering birds. Many species of waterbirds rely specifically on marshes as foraging habitat, making mangrove encroachment a concern for wildlife managers. With the alteration of freshwater flow and sea-level rise trends for the region, mangroves have migrated upstream into traditionally salt and brackish marshes, mirroring similar descriptions around the world. Aside from localized freezes in some years, very little seems to be preventing mangrove encroachment. We mapped changes in mangrove stand boundaries from the Gulf of Mexico inland to the northern boundary of Ten Thousand Islands National Wildlife Refuge (TTINWR) from 1927 to 2005, and determined the area of mangroves to be approximately 7,281 hectares in 2005, representing an 1,878 hectare increase since 1927. Overall change represents an approximately 35% increase in mangrove coverage on TTINWR over 78 years. Sea-level rise is likely the primary driver of this change; however, the construction of new waterways facilitates the dispersal of mangrove propagules into new areas by extending tidal influence, exacerbating encroachment. Reduced volume of freshwater delivery to TTINWR via overland flow and localized rainfall may influence the balance between marsh and mangrove as well, potentially offering some options to managers interested in conserving marsh over mangrove.

  10. Portraying User Interface History

    DEFF Research Database (Denmark)

    Jørgensen, Anker Helms

    2008-01-01

    history. Next the paper analyses a selected sample of papers on UI history at large. The analysis shows that the current state-of-art is featured by three aspects: Firstly internalism, in that the papers adress the tech­nologies in their own right with little con­text­ualization, secondly whiggism...... in that they largely address prevailing UI techno­logies, and thirdly history from above in that they focus on the great deeds of the visionaries. The paper then compares this state-of-art in UI history to the much more mature fields history of computing and history of technology. Based hereon, some speculations......The user interface is coming of age. Papers adressing UI history have appeared in fair amounts in the last 25 years. Most of them address particular aspects such as an in­novative interface paradigm or the contribution of a visionary or a research lab. Contrasting this, papers addres­sing UI...

  11. Environmental history

    DEFF Research Database (Denmark)

    Pawson, Eric; Christensen, Andreas Aagaard

    2017-01-01

    Environmental history is an interdisciplinary pursuit that has developed as a form of conscience to counter an increasingly powerful, forward-looking liberal theory of the environment. It deals with the relations between environmental ideas and materialities, from the work of the geographers Geor...... for solutions and policies, is the agenda for an engaged environmental history from now on.......Environmental history is an interdisciplinary pursuit that has developed as a form of conscience to counter an increasingly powerful, forward-looking liberal theory of the environment. It deals with the relations between environmental ideas and materialities, from the work of the geographers George...... risks”. These are exposed by environmental history’s focus on long-run analysis and its narrative form that identifies the stories that we tell ourselves about nature. How a better understanding of past environmental transformations helps to analyse society and agency, and what this can mean...

  12. Music as therapy in early history.

    Science.gov (United States)

    Thaut, Michael H

    2015-01-01

    The notion of music as therapy is based on ancient cross-cultural beliefs that music can have a "healing" effect on mind and body. Explanations for the therapeutic mechanisms in music have almost always included cultural and social science-based causalities about the uses and functions of music in society. However, it is also important to note that the view of music as "therapy" was also always strongly influenced by the view and understanding of the concepts and causes of disease. Magical/mystical concepts of illness and "rational" medicine probably lived side by side for thousands of years. Not until the late-nineteenth and early-twentieth centuries were the scientific foundations of medicine established, which allowed the foundations of music in therapy to progress from no science to soft science and most recently to actual brain science. Evidence for "early music therapy" will be discussed in four broad historical-cultural divisions: preliterate cultures; early civilizations in Mesopotamia, Egypt, Israel; Greek Antiquity; Middle Ages, Renaissance, and Baroque. In reviewing "early music therapy" practice, from mostly unknown periods of early history (using preliterate cultures as a window) to increasingly better documented times, including preserved notation samples of actual "healing" music, five theories and applications of early music therapy can be differentiated. © 2015 Elsevier B.V. All rights reserved.

  13. A short history of veterinary education in Australia: the 120-year transition from education for a trade to education for a profession.

    Science.gov (United States)

    Caple, I W

    2011-08-01

    World Veterinary Year in 2011 celebrates the 250th anniversary of the establishment of the first modern veterinary school at Lyon in France. To put veterinary education in Australia in its historical context, the veterinary school at Lyon was established nine years before the British had discovered the east coast of Australia in 1770, and 27 years before a shipment of convicts transported from overcrowded gaols in England had arrived in Sydney in 1788. This paper discusses the development of veterinary education in Australia from that time to the present day. © 2011 The Author. Australian Veterinary Journal © 2011 Australian Veterinary Association.

  14. Introducing Labor History.

    Science.gov (United States)

    Whitmer, John Dale

    1997-01-01

    Provides a brief overview for including labor history in the social studies curriculum. Notes the broad range of subjects (geography, history, economics, music, and art) and approaches (women's history, social history, oral history) that encompass labor history. (MJP)

  15. The Challenge of World History

    Science.gov (United States)

    Saldana, Cristobal T.

    2012-01-01

    The author started teaching world history during his first year of teaching at Harlingen High School. To be given such an assignment, because of the breadth of the course, in one's first year might be considered a great misfortune. However, looking back, the author would not have preferred it any other way. World history quickly became his…

  16. Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials?

    Directory of Open Access Journals (Sweden)

    Ioannidis John PA

    2008-05-01

    Full Text Available Abstract Antidepressants, in particular newer agents, are among the most widely prescribed medications worldwide with annual sales of billions of dollars. The introduction of these agents in the market has passed through seemingly strict regulatory control. Over a thousand randomized trials have been conducted with antidepressants. Statistically significant benefits have been repeatedly demonstrated and the medical literature is flooded with several hundreds of "positive" trials (both pre-approval and post-approval. However, two recent meta-analyses question this picture. The first meta-analysis used data that were submitted to FDA for the approval of 12 antidepressant drugs. While only half of these trials had formally significant effectiveness, published reports almost ubiquitously claimed significant results. "Negative" trials were either left unpublished or were distorted to present "positive" results. The average benefit of these drugs based on the FDA data was of small magnitude, while the published literature suggested larger benefits. A second meta-analysis using also FDA-submitted data examined the relationship between treatment effect and baseline severity of depression. Drug-placebo differences increased with increasing baseline severity and the difference became large enough to be clinically important only in the very small minority of patient populations with severe major depression. In severe major depression, antidepressants did not become more effective, simply placebo lost effectiveness. These data suggest that antidepressants may be less effective than their wide marketing suggests. Short-term benefits are small and long-term balance of benefits and harms is understudied. I discuss how the use of many small randomized trials with clinically non-relevant outcomes, improper interpretation of statistical significance, manipulated study design, biased selection of study populations, short follow-up, and selective and distorted

  17. Matematikkens historie

    DEFF Research Database (Denmark)

    Hansen, Vagn Lundsgaard

    2009-01-01

    Matematikkens historie i syv kapitler: 1. Matematik i støbeskeen; 2. Matematikkens græske arv; 3. Den gyldne tidsalder for hinduer og arabere; 4. Matematik i Kina; 5. Renæssancens matematik; 6. Regning med infinitesimaler ser dagens lys; 7. Matematik i det tyvende århundrede.......Matematikkens historie i syv kapitler: 1. Matematik i støbeskeen; 2. Matematikkens græske arv; 3. Den gyldne tidsalder for hinduer og arabere; 4. Matematik i Kina; 5. Renæssancens matematik; 6. Regning med infinitesimaler ser dagens lys; 7. Matematik i det tyvende århundrede....

  18. Under Connecticut Skies: Exploring 100 Years of Astronomy at Van Vleck Observatory in Middletown, Connecticut

    Science.gov (United States)

    Kilgard, Roy E.; Williams, Amrys; Erickson, Paul; Herbst, William; Redfield, Seth

    2017-01-01

    Under Connecticut Skies examines the history of astronomy at Van Vleck Observatory, located on the campus of Wesleyan University in Middletown, Connecticut. Since its dedication in June of 1916, Van Vleck has been an important site of astronomical research, teaching, and public outreach. Over a thousand visitors pass through the observatory each year, and regular public observing nights happen year-round in cooperation with the Astronomical Society of Greater Hartford. Our project explores the place-based nature of astronomical research, the scientific instruments, labor, and individuals that have connected places around the world in networks of observation, and the broader history of how observational astronomy has linked local people, amateur observers, professional astronomers, and the tools and objects that have facilitated their work under Connecticut’s skies over the past 100 years. Our research team has produced a historical exhibition to help commemorate the observatory’s centennial that opened to the public in May of 2016. Our work included collecting, documenting, and interpretting this history through objects, archival documents, oral histories, photographs, and more. The result is both a museum and a working history "laboratory" for use by student and professional researchers. In addition to the exhibit itself, we have engaged in new interpretive programs to help bring the history of astronomy to life. Future work will include digitization of documents and teaching slides, further collection of oral histories, and expanding the collection to the web for use by off-site researches.

  19. A history of childhood trauma is associated with slower improvement rates: Findings from a one-year follow-up study of patients with a first-episode psychosis.

    Science.gov (United States)

    Aas, Monica; Andreassen, Ole A; Aminoff, Sofie R; Færden, Ann; Romm, Kristin L; Nesvåg, Ragnar; Berg, Akiah O; Simonsen, Carmen; Agartz, Ingrid; Melle, Ingrid

    2016-05-04

    The aim of this study was to investigate whether childhood trauma was associated with more severe clinical features in patients with first-episode psychosis, both at the initial assessment and after one year. Ninety-six patients with a first-episode of a DSM-IV diagnosis of psychosis, in addition to 264 healthy controls from the same catchment area, were recruited to the TOP NORMENT study. A history of childhood trauma was obtained using the Childhood Trauma Questionnaire (CTQ). Function and symptom severity were measured using the Global Assessment of Functioning (GAF) Scale divided into function (GAF-F) and symptoms (GAF-S), the Positive and Negative Syndrome Scale (PANSS) and the Young Mania Rating Scale (YMRS). All clinical assessments were completed at two time points: At an initial assessment within the first year of initiating treatment for psychosis and after one year. Childhood trauma was associated with significantly reduced global functioning and more severe clinical symptoms at both baseline and follow-up, whereas emotional neglect was associated with a significantly reduced improvement rate for global functioning (GAF-F) over the follow-up period. Our data indicate that patients with first-episode psychosis who report a history of childhood trauma constitute a subgroup characterized by more severe clinical features over the first year of treatment, as well as slower improvement rates.

  20. ICDP Project DeepCHALLA: Reconstructing 250,000 Years of Climate Change and Environmental History on the East African Equator

    Science.gov (United States)

    Wolff, C.; Verschuren, D.; Van Daele, M. E.; Waldmann, N.; Meyer, I.; Lane, C. S.; Van der Meeren, T.; Ombori, T.; Kasanzu, C.; Olago, D.

    2017-12-01

    Sediments on the bottom of Lake Challa, a 92-m deep crater lake on the border of Kenya and Tanzania near Mt. Kilimanjaro, contain a uniquely long and continuous record of past climate and environmental change in easternmost equatorial Africa. Supported in part by the International Continental Scientific Drilling Programme (ICDP), the DeepCHALLA project has now recovered this sediment record down to 214.8 m below the lake floor, with 100% recovery of the uppermost 121.3 m (the last 160 kyr BP) and ca.85% recovery of the older part of the sequence, down to the lowermost distinct reflector identified in seismic stratigraphy. This acoustic basement represents a ca.2-m thick layer of coarsely laminated, diatom-rich organic mud mixed with volcanic sand and silt deposited 250 kyr ago, overlying an estimated 20-30 m of unsampled lacustrine deposits representing the earliest phase of lake development. Down-hole logging produced profiles of in-situ sediment composition that confer an absolute depth- scale to both the recovered cores and the seismic stratigraphy. An estimated 74% of the recovered sequence is finely laminated (varved), and continuously so over the upper 72.3 m (the last 90 kyr). All other sections display at least cm-scale lamination, demonstrating persistence of a tranquil, profundal depositional environment throughout lake history. The sequence is interrupted only by 32 visible tephra layers 2 to 9 mm thick; and by several dozen fine-grained turbidites up to 108 cm thick, most of which are clearly bracketed between a non-erosive base and a diatom-laden cap. Tie points between sediment markers and the corresponding seismic reflectors support a preliminary age model inferring a near-constant rate of sediment accumulation over at least the last glacial cycle (140 kyr BP to present). This great time span combined with the exquisite temporal resolution of the Lake Challa sediments provides great opportunities to study past tropical climate dynamics at both short

  1. Case report of a 3-year-old girl with pleuropulmonary blastoma and family history of a tumor predisposition syndrome with c. 2830 gene mutation in DICER1

    Directory of Open Access Journals (Sweden)

    Y. Puckett

    2015-08-01

    Full Text Available Pleuropulmonary blastoma (PPB is a childhood mesenchymal pleural-based tumor that is associated with a germline mutation in DICER1 gene in familial PPB. It occurs most commonly in children between the ages of 2 and 5. Approximately 25% of patients have familial cancer syndrome which can include different combinations of PPB, lung cysts, thyroid tumors, cystic nephroma, Wilms tumor, embryonal rhabdomyosarcoma, ovarian Sertoli-Leydig cell tumors, juvenile granulosa cell tumor, gynandroblastoma, medulloblastoma, other childhood central nervous system tumors, nasal chondral mesenchymal hamartoma, and small bowel polyps. Our case report presents a child diagnosed with PPB with maternal history of bilateral ovarian Sertoli-Leydig cell tumors and papillary carcinoma of the thyroid. Molecular analysis performed on the patient and mother showed a specific gene change (c. 2830 in the DICER1 gene. The patient underwent surgical resection of the tumor and five cycles of chemotherapy. Despite this aggressive treatment, she eventually succumbed to brain metastases and was made comfort care after suffering a massive brain hemorrhage several months after the initial diagnosis of her disease.

  2. [Henri Beckquerel's discovery of radioactivity, and history of nuclear medicine. 100 years in the shadow or on the shoulder of Röntgen].

    Science.gov (United States)

    Rootwelt, K

    1996-12-10

    In 1896 Henri Becquerel discovered that uranium emitted penetrating rays similar to X-rays. His finding started a series of discoveries that were rewarded with numerous Nobel prizes. Marie and Pierre Curie found that thorium was radioactive too, and discovered and described two new elements, polonium and radium. They also found that radioactive radiation could be separated into alpha, beta and gamma rays. In 1993 their daughter Irene Joliot-Curie and her husband Frederic Joliot managed to produce radioactivity artificially by bombarding atomic nuclei with alpha particles. Enrico Fermi did likewise, but bombarded the nuclei with neutrons. In the cyclotron invented by Ernest Lawrence, radioactive isotopes were produced by proton bombardment. The ability to produce radioisotopes of different elements initiated a variety of tracer studies in biology and medicine. The number of studies increased exponentially when the nuclear reactor in Oak Ridge, US, was opened for radionuclide production in 1946. This article summarises the history of the application of radionuclides in science and medicine internationally and in Norway until now.

  3. LANDSAT-derived 28-year history of phytoplankton blooms in Western Lake Erie shows changes in peak bloom timing and challenges due to phytoplankton species variability

    Science.gov (United States)

    Ho, J. C.; Michalak, A. M.; Stumpf, R. P.

    2016-02-01

    Information on historical phytoplankton blooms can yield insight that can be used to tackle present-day challenges in inland waters. Thus far, attempts to use historical information to understand long-term changes relevant for present-day management have been stymied by a limited historical record in many freshwater systems. For Lake Erie, we augment the existing record based on MERIS imagery that begins in 2002 by gleaning information on the spatial extent and timing of blooms for 1984-2001 from LANDSAT 5 imagery. Despite limitations stemming from LANDSAT's long revisit period and regular cloudiness obscuring scenes, we demonstrate that remotely-sensed historical data add relevant context for addressing current blooms by documenting the presence, magnitude, and timing of past blooms. Comparing the remotely-sensed history to the sparse in situ data taken during this period, we find that new information can be gleaned about historical bloom presence, magnitude, and seasonality despite LANDSAT's limitations. We also find that the remotely-sensed record shows systematic differences in the remotely sensed signal as a function of the colony size of the dominant phytoplankton species present, providing a note of caution for using remote sensing to monitor water quality in systems with multiple phytoplankton regime shifts.

  4. Ildens historier

    DEFF Research Database (Denmark)

    Lassen, Henrik Roesgaard

    have been written by Andersen. In several chapters the curiously forgotten history of fire-lighting technology is outlined, and it is demonstrated that "Tællelyset" is written by a person with a modern perspective on how to light a candle - among other things. The central argument in the book springs...

  5. Business History

    DEFF Research Database (Denmark)

    Hansen, Per H.

    2012-01-01

    This article argues that a cultural and narrative perspective can enrich the business history field, encourage new and different questions and answers, and provide new ways of thinking about methods and empirical material. It discusses what culture is and how it relates to narratives. Taking...

  6. Phylogeography of the walnut twig beetle, Pityophthorus juglandis, the vector of thousand cankers disease in North American walnut trees

    Science.gov (United States)

    Paul F. Rugman-Jones; Steven J. Seybold; Andrew D. Graves; Richard. Stouthamer

    2015-01-01

    Thousand cankers disease (TCD) of walnut trees (Juglans spp.) results from aggressive feeding in the phloem by the walnut twig beetle (WTB), Pityophthorus juglandis, accompanied by inoculation of its galleries with a pathogenic fungus, Geosmithia morbida. In 1960, WTB was only known from four U.S. counties...

  7. Efficacy of Heat Treatment for the Thousand Cankers Disease Vector and Pathogen in Small Black Walnut Logs

    Science.gov (United States)

    A. E. Mayfield; S. W. Fraedrich; A. Taylor; P. Merten; S. W. Myers

    2014-01-01

    Thousand cankers disease, caused by the walnut twig beetle (Pityophthorus juglandis Blackman) and an associated fungal pathogen (Geosmithia morbida M. Kolarõ´k, E. Freeland, C. Utley, and N. Tisserat), threatens the health and commercial use of eastern black walnut (Juglans nigra L.), one of the most economically...

  8. RUMD: A general purpose molecular dynamics package optimized to utilize GPU hardware down to a few thousand particles

    DEFF Research Database (Denmark)

    Bailey, Nicholas; Ingebrigtsen, Trond; Hansen, Jesper Schmidt

    2017-01-01

    RUMD is a general purpose, high-performance molecular dynamics (MD) simulation package running on graphical processing units (GPU’s). RUMD addresses the challenge of utilizing the many-core nature of modern GPU hardware when simulating small to medium system sizes (roughly from a few thousand up...

  9. The formative years of relativity the history and meaning of Einstein's Princeton lectures : featuring Einstein's classic text The meaning of relativity in its historical context

    CERN Document Server

    Gutfreund, Hanoch

    2017-01-01

    First published in 1922 and based on lectures delivered in May 1921, Albert Einstein's The Meaning of Relativity offered an overview and explanation of the then new and controversial theory of relativity. The work would go on to become a monumental classic, printed in numerous editions and translations worldwide. Now, The Formative Years of Relativity introduces Einstein's masterpiece to new audiences. This beautiful volume contains Einstein's insightful text, accompanied by important historical materials and commentary looking at the origins and development of general relativity. Hanoch Gutfreund and Jurgen Renn provide fresh, original perspectives, placing Einstein's achievements into a broader context for all readers. In this book, Gutfreund and Renn tell the rich story behind the early reception, spread, and consequences of Einstein's ideas during the formative years of general relativity in the late 1910s and 1920s. They show that relativity's meaning changed radically throughout the nascent years of it...

  10. A short note from the history of traditional music of the Serbs in Vojvodina: To mark two hundred years of the first recorded wedding song

    Directory of Open Access Journals (Sweden)

    Karin Vesna

    2016-01-01

    Full Text Available The well-known wedding song 'Odbi se grana od jorgovana' dates back to 1815 when it was recorded by Franciszek Mirecki. It was sung to him by a woman who was Vuk Stefanović Karadžić's informant (Dević, 1991: 129. Specific in its character and melodic pattern, the wedding song held an important position in the wedding ceremony of native Serbs in the region of present-day Vojvodina. In the year of 2015 it had been exactly two hundred years since it was first notated.

  11. Obesity History and Daily Patterns of Physical Activity at Age 60-64 Years: Findings From the MRC National Survey of Health and Development.

    Science.gov (United States)

    Cooper, Rachel; Huang, Lei; Hardy, Rebecca; Crainiceanu, Adina; Harris, Tamara; Schrack, Jennifer A; Crainiceanu, Ciprian; Kuh, Diana

    2017-10-01

    The aim of this study was to investigate associations of current body mass index (BMI) and obesity history with daily patterns of physical activity. At age 60-64, participants from a British birth cohort study wore accelerometers for 5 days. Accelerometry counts were log-transformed and mean log-counts were used to derive a summary variable indicating total daily log-activity counts. Among those with complete data (n = 1,388) the associations of current BMI and age of first obesity were examined with: (a) total daily log-activity counts and (b) total log-activity counts in four segments of the day. Higher current BMI and younger age at obesity were strongly associated with lower levels of total daily activity at age 60-64 even after adjustment for sex, socioeconomic factors, and health status. The fully-adjusted mean difference in total daily log-activity counts was -581.7 (95% confidence interval: -757.2, -406.3) when comparing BMI ≥35 kg/m2 with <25 kg/m2, representing an 18.4% difference. Participants who had been obese since early adulthood had the lowest levels of activity (mean difference in total daily log-activity counts was -413.1 (-638.1, -188.2) when comparing those who were obese by age 26 or 36 with those who were never obese, representing a 13.1% difference). Obese older adults may require targeted interventions and additional support to improve their daily activity levels. As younger generations with greater lifetime exposure to obesity reach old age the proportion of adults achieving sufficient levels of activity to realize its associated health benefits is likely to decline. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America.

  12. Examining the Impact of Prior Criminal Justice History on 2-Year Recidivism Rates: A Comparison of Drug Court Participants and Program Referrals.

    Science.gov (United States)

    Shannon, Lisa M; Jackson Jones, Afton; Newell, Jennifer; Neal, Connie

    2018-02-01

    Drug courts seek to break the cycle of substance use and crime by providing a community-based intervention to individuals with criminal justice involvement and substance-related issues. This study examined recidivism over a 2-year follow-up period as well as factors associated with recidivism for a sample of drug court participants (i.e., graduates and terminators) and a non-equivalent comparison group (i.e., individuals referred/assessed for the program who did not enter). In the 2-year follow-up window, fewer drug court graduates had any convictions compared with program terminators and referrals; specifically, fewer drug court graduates had drug trafficking convictions compared with program terminators and referrals. Fewer graduates were arrested and incarcerated in jail and/or prison in the 2-year follow-up; furthermore, graduates had spent less time incarcerated compared with program terminators and referrals. Demographics (i.e., age, race, marital status) and prior criminal justice system involvement were associated with recidivism; however, these factors had differential impacts for the three groups (i.e., graduates, terminators, and referrals). Drug court shows promise as a community-based intervention that helps keep individuals out of the criminal justice system during a 2-year follow-up period.

  13. From Performance to Decision Processes in 33 Years: A History of Organizational Behavior and Human Decision Processes under James C. Naylor.

    Science.gov (United States)

    Weber

    1998-12-01

    For the past 33 years, Organizational Behavior and Human Decision Processes has thrived under a single editor. That editor, James C. Naylor, is retiring from his long stewardship. This article chronicles the course of the journal under Jim's direction and marks some of the accomplishments and changes over the past three decades that go to his credit. Copyright 1998 Academic Press.

  14. Physical development and medical history of children who were treated antenatally with corticosteroids to prevent respiratory distress syndrome: a 10- to 12-year follow-up

    NARCIS (Netherlands)

    Smolders-de Haas, H.; Neuvel, J.; Schmand, B.; Treffers, P. E.; Koppe, J. G.; Hoeks, J.

    1990-01-01

    Potential side effects of antenatal administration of corticosteroids to prevent neonatal respiratory distress syndrome were studied in 10- to 12-year-old children whose mothers had participated in a randomized, double-blind, placebo-controlled trial of betamethasone. The children had a general

  15. Fossil and active fumaroles in the 1912 eruptive deposits, Valley of ten thousand smokes, Alaska

    Science.gov (United States)

    Keith, T.E.C.

    1991-01-01

    Fumaroles in the ash-flow sheet emplaced during the 1912 eruption of Novarupta were intensely active throughout the Valley of Ten Thousand Smokes (VTTS) when first studied in 1917. Fumarole temperatures recorded in 1919 were as hot as 645??C. Influx of surface waters into the hot ash-flow sheet provided the fluid flow to sustain the fumaroles but also enhanced cooling so that by the mid-1930's vigorous activity survived only in the vent region. Configuration and distribution of high-temperature fissure fumaroles tens of meters long, that are prevalent in the middle and upper VTTS, were controlled largely by sintering and degree of welding, which in turn controlled fracturing and permeability of the ash-flow tuff. One fracture type developed parallel to the enclosing valley walls during compaction of the ash-flow sheet. Another type extends across the VTTS nearly perpendicular to the flow direction. A third type of randomly oriented fractures developed as cooling contraction cracks during vapor-phase devitrification. In distal parts of the ash-flow sheet where the tuff is nonwelded, prominent fumaroles have irregular funnel-shaped morphologies. Fumarole distribution in the nonwelded part of the ash-flow sheet is concentrated above pre-emplacement river channels. The hottest, longest-lived fumaroles occurred in the upper VTTS near the 1912 vent where the ash-flow sheet is thicker, more indurated, and on average more mafic (richer in dacite and andesite) in contrast to the thinner, nonwelded rhyolitic tuff in the distal part of the sheet. Fumarolic activity was less intense in the distal part of the tuff because of lower emplacement temperatures, more diffuse fumarole conduits in the nonwelded tuff, and the thinness of the ash-flow sheet. Chemical leaching of ash-flow tuff by hot rising fluids took place adjacent to fumarolic conduits in deep parts of the fumaroles. Deposition of incrustation minerals, the components of which were carried upward by fumarolic gases

  16. Business History as Cultural History

    DEFF Research Database (Denmark)

    Lunde Jørgensen, Ida

    The paper engages with the larger question of how cultural heritage becomes taken for granted and offers a complimentary view to the anthropological ʻCopenhagen School’ of business history, one that draws attention to the way corporate wealth directly and indirectly influences the culture available...

  17. Linking growth to environmental histories in central Baltic young-of-the-year sprat, Sprattus sprattus : an approach based on otolith microstructure analysis and hydrodynamic modelling

    DEFF Research Database (Denmark)

    Baumann, H.; Hinrichsen, H.H.; Voss, R.

    2006-01-01

    Otolith microstructure analysis and hydrodynamic modelling were combined to study growth patterns in young-of-the-year (YoY) sprat, Sprattus sprattus, which were sampled in October 2002 in the central Baltic Sea. The observed 'window of survival', approximated by the distribution of back-calculat......Otolith microstructure analysis and hydrodynamic modelling were combined to study growth patterns in young-of-the-year (YoY) sprat, Sprattus sprattus, which were sampled in October 2002 in the central Baltic Sea. The observed 'window of survival', approximated by the distribution of back......-calculated days of first feeding (DFF), was narrow compared to the extended spawning season of sprat in the Baltic Sea (mean +/- SD = 22 June +/- 14.1 days) and indicated that only individuals born in summer survived until October 2002. Within the group of survivors, individuals born later in the season exhibited...

  18. Publication of the Korea-WHO Cooperation History - 70 Years of Working Together for Heath: World Health Organization and the Republic of Korea.

    Science.gov (United States)

    Cho, Heeyeon; Lee, Dong Woo; Choe, Young June; Choe, Seung Ah; Park, No Yai

    2017-03-01

    The World Health Organization (WHO) have been in collaborative efforts with the Republic of Korea in keeping of and for better health for all for the past decades. From the control of parasites to building of community health system in rural places, the works has now resulted in healthier Korea than ever, and has transformed the role of engaging as the world leader in contribution of health and development. Seventy years of independence, war, and poverty, transforming from a recipient country of official development assistance to a significant donor to the global society, we have emphasized the importance of international cooperation and the role of WHO in the past years in Korea and neighboring countries. Looking back of the past is meaningful to diagnose the present problems, and to foresee the future of our world.

  19. A brief history of space and time: the scope-year index as a patent value indicator based on families and renewals

    OpenAIRE

    Bruno Van Pottelsberghe; Nicolas van Zeebroeck

    2008-01-01

    The renewal of patents and their geographical scope for protection constitute two essential dimensions in a patent’s life, and probably the most frequently used patent value indicators. The intertwining of these dimensions (the geographical scope of protection may vary over time) makes their analysis complex, as any measure along one dimension requires an arbitrary choice on the second. This paper proposes a new indicator of patent value, the Scope-Year index, combining the two dimensions. Th...

  20. Stratigraphic and microfossil evidence for a 4500-year history of Cascadia subduction zone earthquakes and tsunamis at Yaquina River estuary, Oregon, USA

    Science.gov (United States)

    Graehl, Nicholas A; Kelsey, Harvey M.; Witter, Robert C.; Hemphill-Haley, Eileen; Engelhart, Simon E.

    2015-01-01

    intervals.The comparison of the Yaquina Bay earthquake record to similar records at other Cascadia coastal sites helps to define potential patterns of rupture for different earthquakes, although inherent uncertainty in dating precludes definitive statements about rupture length during earthquakes. We infer that in the first half of the last millennia, the northern Oregon part of the subduction zone had a different rupture history than the southern Oregon part of the subduction zone, and we also infer that at ca. 1.6 ka, two earthquakes closely spaced in time together ruptured a length of the megathrust that extends at least from southwestern Washington to southern Oregon.

  1. Observing Children Learning History.

    Science.gov (United States)

    Blake, David W.

    1981-01-01

    Compares the suitability of two kinds of history curricula for the varying levels of cognitive development of 9- to 11-year-olds. Fifteen British students studied the Victorian Era using transcripts of original documents, while 15 classmates used standard textbooks. The documents seemed to give students greater awareness of the evidence sources.…

  2. Atmospheric refraction : a history

    NARCIS (Netherlands)

    Lehn, WH; van der Werf, S

    2005-01-01

    We trace the history of atmospheric refraction from the ancient Greeks up to the time of Kepler. The concept that the atmosphere could refract light entered Western science in the second century B.C. Ptolemy, 300 years later, produced the first clearly defined atmospheric model, containing air of

  3. User Interface History

    DEFF Research Database (Denmark)

    Jørgensen, Anker Helms; Myers, Brad A

    2008-01-01

    User Interfaces have been around as long as computers have existed, even well before the field of Human-Computer Interaction was established. Over the years, some papers on the history of Human-Computer Interaction and User Interfaces have appeared, primarily focusing on the graphical interface era...

  4. Sommerferiens historie

    DEFF Research Database (Denmark)

    Lützen, Karin

    2011-01-01

    Summer holiday is a pleasure which did not become available to many people until the 20th Century. The article describes the early mountain rambles of the bourgeoisie and their holidays in seaside boarding houses. Outdoor pursuits and stays in boarding houses at bathing resorts also became...... pattern. Finally, the history of the special holiday camps is told, which were established by American Jews because they were excluded from many hotels....

  5. River history.

    Science.gov (United States)

    Vita-Finzi, Claudio

    2012-05-13

    During the last half century, advances in geomorphology-abetted by conceptual and technical developments in geophysics, geochemistry, remote sensing, geodesy, computing and ecology-have enhanced the potential value of fluvial history for reconstructing erosional and depositional sequences on the Earth and on Mars and for evaluating climatic and tectonic changes, the impact of fluvial processes on human settlement and health, and the problems faced in managing unstable fluvial systems. This journal is © 2012 The Royal Society

  6. Natural History of Dependency in the Elderly: A 24-Year Population-Based Study Using a Longitudinal Item Response Theory Model.

    Science.gov (United States)

    Edjolo, Arlette; Proust-Lima, Cécile; Delva, Fleur; Dartigues, Jean-François; Pérès, Karine

    2016-02-15

    We aimed to describe the hierarchical structure of Instrumental Activities of Daily Living (IADL) and basic Activities of Daily Living (ADL) and trajectories of dependency before death in an elderly population using item response theory methodology. Data were obtained from a population-based French cohort study, the Personnes Agées QUID (PAQUID) Study, of persons aged ≥65 years at baseline in 1988 who were recruited from 75 randomly selected areas in Gironde and Dordogne. We evaluated IADL and ADL data collected at home every 2-3 years over a 24-year period (1988-2012) for 3,238 deceased participants (43.9% men). We used a longitudinal item response theory model to investigate the item sequence of 11 IADL and ADL combined into a single scale and functional trajectories adjusted for education, sex, and age at death. The findings confirmed the earliest losses in IADL (shopping, transporting, finances) at the partial limitation level, and then an overlapping of concomitant IADL and ADL, with bathing and dressing being the earliest ADL losses, and finally total losses for toileting, continence, eating, and transferring. Functional trajectories were sex-specific, with a benefit of high education that persisted until death in men but was only transient in women. An in-depth understanding of this sequence provides an early warning of functional decline for better adaptation of medical and social care in the elderly. © The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  7. The growth and evolution of cardiovascular magnetic resonance: a 20-year history of the Society for Cardiovascular Magnetic Resonance (SCMR) annual scientific sessions.

    Science.gov (United States)

    Lee, Daniel C; Markl, Michael; Dall'Armellina, Erica; Han, Yuchi; Kozerke, Sebastian; Kuehne, Titus; Nielles-Vallespin, Sonia; Messroghli, Daniel; Patel, Amit; Schaeffter, Tobias; Simonetti, Orlando; Valente, Anne Marie; Weinsaft, Jonathan W; Wright, Graham; Zimmerman, Stefan; Schulz-Menger, Jeanette

    2018-01-31

    The purpose of this work is to summarize cardiovascular magnetic resonance (CMR) research trends and highlights presented at the annual Society for Cardiovascular Magnetic Resonance (SCMR) scientific sessions over the past 20 years. Scientific programs from all SCMR Annual Scientific Sessions from 1998 to 2017 were obtained. SCMR Headquarters also provided data for the number and the country of origin of attendees and the number of accepted abstracts according to type. Data analysis included text analysis (key word extraction) and visualization by 'word clouds' representing the most frequently used words in session titles for 5-year intervals. In addition, session titles were sorted into 17 major subject categories to further evaluate research and clinical CMR trends over time. Analysis of SCMR annual scientific sessions locations, attendance, and number of accepted abstracts demonstrated substantial growth of CMR research and clinical applications. As an international field of study, significant growth of CMR was documented by a strong increase in SCMR scientific session attendance (> 500%, 270 to 1406 from 1998 to 2017, number of accepted abstracts (> 700%, 98 to 701 from 1998 to 2018) and number of international participants (42-415% increase for participants from Asia, Central and South America, Middle East and Africa in 2004-2017). 'Word clouds' based evaluation of research trends illustrated a shift from early focus on 'MRI technique feasibility' to new established techniques (e.g. late gadolinium enhancement) and their clinical applications and translation (key words 'patient', 'disease') and more recently novel techniques and quantitative CMR imaging (key words 'mapping', 'T1', 'flow', 'function'). Nearly every topic category demonstrated an increase in the number of sessions over the 20-year period with 'Clinical Practice' leading all categories. Our analysis identified three growth areas 'Congenital', 'Clinical Practice', and 'Structure

  8. Signs of reactive attachment disorder and disinhibited social engagement disorder at age 12 years: Effects of institutional care history and high-quality foster care.

    Science.gov (United States)

    Humphreys, Kathryn L; Nelson, Charles A; Fox, Nathan A; Zeanah, Charles H

    2017-05-01

    Two disorders of attachment have been consistently identified in some young children following severe deprivation in early life: reactive attachment disorder and disinhibited social engagement disorder. However, less is known about whether signs of these disorders persist into adolescence. We examined signs of reactive attachment disorder and disinhibited social engagement disorder at age 12 years in 111 children who were abandoned at or shortly after birth and subsequently randomized to care as usual or to high-quality foster care, as well as in 50 comparison children who were never institutionalized. Consistent with expectations, those who experienced institutional care in early life had more signs of reactive attachment disorder and disinhibited social engagement disorder at age 12 years than children never institutionalized. In addition, using a conservative intent-to-treat approach, those children randomized to foster care had significantly fewer signs of reactive attachment disorder and disinhibited social engagement disorder than those randomized to care as usual. Analyses within the ever institutionalized group revealed no effects of the age of placement into foster care, but number of caregiving disruptions experienced and the percentage of the child's life spent in institutional care were significant predictors of signs of attachment disorders assessed in early adolescence. These findings indicate that adverse caregiving environments in early life have enduring effects on signs of attachment disorders, and provide further evidence that high-quality caregiving interventions are associated with reductions in both reactive attachment disorder and disinhibited social engagement disorder.

  9. To the History of Financial and Economic Activity of the Volga River Transport During the NEP and the First Five-Year Period

    Directory of Open Access Journals (Sweden)

    Gomanenko Olesya Aleksandrovna

    2016-04-01

    Full Text Available The Volga transport for 10 years (1923-1934 was influenced by all those changes which happened in the national economy of the country during the periods of the New Economic Policy and its transition to the forced industrialization. Since 1923 attempts of its delivery to concession in connection with the project of creation of the Volga-Don-Azov Sea hydraulic engineering constructions by means of the Western firms and banks took place. In 1929 those attempts ended without any results. Most likely, threat of outflow from the USSR of scarce currency in the form of profits of concessionaires was the main cause. That threat moved promises of foreign firms to significantly modernize and expand the Volga transport with all its coastal infrastructure, and also to promote creation of “new freights” in a zone of operations of the Volga fleet. Up to its reorganization in 1934 the Volga fleet constantly experienced the financial and technical difficulties caused by wear of watercrafts, low tariffs for a cargo transportation, etc. However, these low tariffs allowed the large new enterprises and constructions of the first five-year plans period to reduce their transport expenses. It favorably affected the process of industrialization of the Volga region and other ones. Losses on freight transportation were offset by the Volga water transport due to passenger traffic by increasing the high efficiency of passenger capacity of ships, an intensification of a passenger traffic and increase of a passenger tariff.

  10. A history of Guy's, King's and St. Thomas' hospitals from 1649 to 2009: 360 years of innovation in science and surgery.

    Science.gov (United States)

    Agha, Riaz; Agha, Maliha

    2011-01-01

    Much has been achieved in the scientific and surgical fields over the last 360 years. Some institutions have contributed disproportionately to these advances. The medical schools and hospitals of Guy's (est. 1721), King's (est. 1840) and St. Thomas' (est. 1173) seem to provide a focus and a catalyst for much innovation and creativity dating back to 1608. This review sets to provide an overview of the major contributors to surgical advances at these institutions over the last 360 years and what factors affected unique to these institutions contributed to the climate of discovery. It is based on a lecture given to the Osler Club of London (est. 1928) at the Royal College of Physicians in London on 4 November 2010. It is the author's premise that the people and the discoveries they made within these institutions within three square miles of London changed the practice and understanding of science and healthcare as we know it today. Copyright © 2011 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

  11. Curators and Australian art history

    OpenAIRE

    Andrew Sayers

    2011-01-01

    Most Australians do not read art history, but they do look at art in museums. There, visitors experience displays that embody art histories. The enthusiasms and research interests of curators combine with collection strengths to create these art histories. In this process, particular artists, ideas and mediums are privileged. Drawing on personal experience this talk looked at some examples of influential curators, displays, exhibitions and collecting programs over the last thirty years. In th...

  12. The natural history of takotsubo syndrome: a two-year follow-up study with myocardial sympathetic and perfusion G-SPECT imaging

    Energy Technology Data Exchange (ETDEWEB)

    Sestini, Stelvio; Mazzeo, Christian; Castagnoli, Antonio [Nuclear Medicine Unit, N.O.P. - S. Stefano, U.S.L. Toscana Centro, Deptartment of Diagnostic Imaging, Prato (Italy); Pestelli, Francesco; Leoncini, Mario; Bellandi, Francesco [Cardiovascular Unit, N.O.P. - S. Stefano, U.S.L, Toscana Centro, Deptartment of Internal Medicine, Prato (Italy); Mansi, Luigi [Nuclear Medicine Unit, University II Naples, Deptartment of Diagnostic Imaging, Naples (Italy); Carrio, Ignasi [Hospital Sant Pau, Nuclear Medicine, Barcelona (Spain)

    2017-02-15

    To investigate changes in sympathetic activity, perfusion, and left ventricular (LV) functionality in takotsubo cardiomyopathy (TTC) patients from onset (T{sub 0}) to post-onset conditions at 1 month (T{sub 1}), 1-2 years (T{sub 2}, T{sub 3}). Twenty-two patients (70 ± 11 years) underwent serial gated single photon emission tomography (G-SPECT) studies with {sup 123}I-mIBG and {sup 99m}Tc-Sestamibi. Statistics were performed using ANOVA/Sheffe post-hoc, correlation test, and receiver operating characteristic (ROC) curve analysis (p < 0.05). Patients presented at T{sub 0} with LV ballooning and reduced early-late mIBG uptake (95%, 100%), left ventricular ejection fraction (LVEF){sub G-SPECT} (86%) and perfusion (77 %). Adrenergic dysfunction was greater in apex, it overlaps with contractile impairment, and both were more severe than perfusion defect. During follow-up, LVEF{sub G-SPECT}, contractility, and perfusion were normal, while 82% and 90% of patients at T{sub 1} and 50% at T{sub 2} and T{sub 3} continued to show a reduced apical early-late mIBG distribution. These patients presented at T{sub 0}-T{sub 1} with greater impairment of adrenergic function, contractility, and perfusion. A relationship was present within innervation and both perfusion and contractile parameters at T{sub 0} and T{sub 1}, and between the extent of adrenergic defect at T{sub 3} and both the defect extent and age at T{sub 0} (cut-off point 42.5%, 72 years). Outcome for TTC is not limited to a reversible contractile and perfusion abnormalities, but it includes residual adrenergic dysfunction, depending on the level of adrenergic impairment and age of patients at onset. The number of patients, as well as degree of perfusion abnormalities were found to be higher than those previously reported possibly depending on the time-interval between hospital admission and perfusion scan. (orig.)

  13. Adjacent segment pathology: natural history or effect of anterior cervical discectomy and fusion? A 10-year follow-up radiological multicenter study using an evaluation scale of the ageing spine.

    Science.gov (United States)

    Pesce, Alessandro; Wierzbicki, Venceslao; Piccione, Emanuele; Frati, Alessandro; Raco, Antonino; Caruso, Riccardo

    2017-05-01

    Aim of this study is to compare late degenerative MRI changes in a subset of patients operated on with ACDF to a second subset of patients presenting indication to ACDF but never operated on. Patients from both subgroups received surgical indication according to the same criteria. Both subgroups underwent a cervical spine MRI in 2004-2005 and 10 years later in 2015. These MRI scans were retrospectively evaluated with a cervical spine ageing scale. Comparing the two subset of patients both suffering from clinically relevant single-level disease returns no statistically significant difference in the degenerative condition of posterior ligaments, presence of degenerative spondylolisthesis, foraminal stenosis, diameter of the spinal canal, Modic alteration, and intervertebral discs degeneration at 10-year follow-up. The adjacent segment degeneration represents, in the present cohort, a result of the natural history of cervical spondylosis rather than a consequence of fusion.

  14. A history of the Water Resources Branch of the United States Geological Survey: volume 4, years of World War II, July 1, 1939 to June 30, 1947

    Science.gov (United States)

    Follansbee, Robert

    1939-01-01

    This period extends from July 1, 1939, to June 30, 1947, and is called the years of World War II, although it was not until December 1941 that the United States entered the war which began in Europe in September 1939. By the beginning of the period, it was evident that this country might be drawn into the conflict and a rearmament program including the draft act , effective in September 1940, was started and prosecuted vigorously prior to December 1941, when the attack on Pearl Harbor forced us into the war. Although the war was not officially ended by June 1947, President Truman proclaimed the end of hostilities on December 31, 1946, thus terminating some of his war-time powers, and by further action terminated other war-time powers as of June 30, 1947.

  15. Climate history of the Tibetan Plateau for the last 1500 years as inferred from stable carbon isotopes in three-rings

    International Nuclear Information System (INIS)

    Helle, G.; Schleser, G.H.; Braeuning, A.

    2002-01-01

    For the south-eastern part of Tibet, i.e. Qamdo, a carbon isotope chronology from spruce and juniper trees, covering the last 400 and 1600 years, respectively, has been developed. Juniper tree-rings were sampled in pentad blocks, whereas the spruce chronology is annually resolved in order enable appropriate calibration of isotope data with the short instrumental temperature record available. The chronology shows a number of different climatic phases which have their analogues in Europe and North America. A short warm phase between 1200 and 1300AD appears to correspond to the Mediaeval Warm Period and a larger cool phase from about 1450 to 1600AD appears to correspond to the Little Ice Age with a short recurring episode around 1850. The current results suggest that the observed events may have occurred over the entire Northern Hemisphere, though they do not seem to have been contemporaneous with Europe and North America. (author)

  16. A hundred-year of Karl Jaspers' General Psychopathology (Allgemeine Psychopathologie)--1913-2013: a pivotal book in the history of psychiatry.

    Science.gov (United States)

    Nardi, Antonio Egidio; Freire, Rafael Christophe; Machado, Sergio; Silva, Adriana Cardoso; Crippa, José Alexandre

    2013-07-01

    After a hundred-years of its publication, the Karl Jaspers' book, General Psychopathology, is still an indispensable book to psychiatrists and for all those who study psychopathology. It's a clear delineation of the phenomenological method for describing the symptoms of mental disorders that remains unmatched until nowadays. The book focuses on the relevance of phenomenological and hermeneutical methods in psychopathology. Although this work is grounded in the clinical thought and practices of the late nineteenth and early twentieth centuries, Jaspers' delineation of psychiatric methods in this work is still evaluated as unmatched to this day, a work that is indispensable to contemporary psychiatry. Jaspers also contributed with important articles and book reviews to psychiatric periodicals during the first two decades of the twentieth century.

  17. The Chronic Encephalopathy of Parry Romberg Syndrome and En Coupe De Sabre with a 31-Year-History in a West Indian Woman: Clinical, Immunologic and Neuroimaging Abnormalities.

    Science.gov (United States)

    Seegobin, Karan; Abdool, Kamille; Ramcharan, Kanterpersad; Dyaanand, Haramnauth; Rampersad, Fidel

    2016-09-30

    We describe a case of Parry Romberg syndrome/ en coupe de sabre in a woman whose disease started as seizures at age 8 but was diagnosed at the age 39. During these 31 years she got married, completed a first degree at university, had two successful pregnancies and has been gainfully employed. The features of generalized tonic-clonic seizures, autoimmune abnormalities, ocular abnormalities, morphea en coup de sabre and brain imaging abnormalities were present. Areas of parietal lobe cerebral calcification were encountered on the computed tomographic scan and bilateral periventricular white matter changes on the magnetic resonance imaging with frontal, temporal and parietal lobe brain atrophy ipsilateral to the facial hemiatrophy. Clinical, immunologic and neuroradiological abnormalities are discussed. In some cases, this illness can run a benign and stable course.

  18. The chronic encephalopathy of Parry Romberg Syndrome and en coupe de sabre with a 31-year-history in a West Indian woman: clinical, immunologic and neuroimaging abnormalities

    Directory of Open Access Journals (Sweden)

    Karan Seegobin

    2016-09-01

    Full Text Available We describe a case of Parry Romberg syndrome/ en coupe de sabre in a woman whose disease started as seizures at age 8 but was diagnosed at the age 39. During these 31 years she got married, completed a first degree at university, had two successful pregnancies and has been gainfully employed. The features of generalized tonic-clonic seizures, autoimmune abnormalities, ocular abnormalities, morphea en coup de sabre and brain imaging abnormalities were present. Areas of parietal lobe cerebral calcification were encountered on the computed tomographic scan and bilateral periventricular white matter changes on the magnetic resonance imaging with frontal, temporal and parietal lobe brain atrophy ipsilateral to the facial hemiatrophy. Clinical, immunologic and neuroradiological abnormalities are discussed. In some cases, this illness can run a benign and stable course.

  19. Experience and Life History. Roskilde University Life History Project Paper.

    Science.gov (United States)

    Salling Olesen, Henning

    The Life History Project at Denmark's Roskilde University is a 5-year research project that was initiated in 1998 to examine learning and participation in adult and continuing education from a life history perspective. The project was designed to build on a broad range of qualitative interview studies and case studies into learning processes. The…

  20. Internal prostatic architecture on transrectal ultrasonography predicts future prostatic growth: natural history of prostatic hyperplasia in a 15-year longitudinal community-based study.

    Science.gov (United States)

    Fukuta, Fumimasa; Masumori, Naoya; Mori, Mitsuru; Tsukamoto, Taiji

    2011-05-01

    From 1992 to 1993, we conducted a cross-sectional community-based study to clarify the prevalence of benign prostatic hyperplasia in Japanese men aged 40-79. Based on the results, we hypothesized that the internal prostatic architecture (IPA) on transrectal ultrasonography (TRUS) would predict future prostatic growth. We investigated the changes in prostate volume (PV) over time and validated our hypothesis on predictors for future prostatic growth. Of 319 participants in the initial study, the PV of 104 men was evaluated by TRUS with approximately a 15-year follow-up in the current study. We categorized prostates into three groups based on the IPA: group 1, invisible transition zone (TZ); group 2, visible TZ with an unclear border; and group 3, visible TZ with a clear border. Overall PV significantly increased from 17.4  ml to 23.9  ml (P  <  0.001). The median PV changes by age decade (40s, 50s, 60s, and 70s) were 5.5, 5.6, 8.6, and 11.1  ml, respectively. Those by baseline PV < 20  ml, 20-25  ml, and ≥ 25  ml were 5.3, 9.8, and 14.7  ml, respectively. Those by baseline IPA for group 1, group 2, and group 3 were 4.7, 6.5, and 17.3  ml, respectively. Multiple linear regression analysis indicated that PV (P  =  0.027) and the IPA (P  <  0.001) at baseline were independent predictors for future prostatic growth. This was the first study by longitudinal community-based study that the PV in Japanese men increased during 15 years. The IPA on TRUS is useful for predicting future prostatic growth. Copyright © 2010 Wiley-Liss, Inc.

  1. History of human activity in last 800 years reconstructed from combined archive data and high-resolution analyses of varved lake sediments from Lake Czechowskie, Northern Poland

    Science.gov (United States)

    Słowiński, Michał; Tyszkowski, Sebastian; Ott, Florian; Obremska, Milena; Kaczmarek, Halina; Theuerkauf, Martin; Wulf, Sabine; Brauer, Achim

    2016-04-01

    The aim of the study was to reconstruct human and landscape development in the Tuchola Pinewoods (Northern Poland) during the last 800 years. We apply an approach that combines historic maps and documents with pollen data. Pollen data were obtained from varved lake sediments at a resolution of 5 years. The chronology of the sediment record is based on varve counting, AMS 14C dating, 137Cs activity concentration measurements and tephrochronology (Askja AD 1875). We applied the REVEALS model to translate pollen percentage data into regional plant abundances. The interpretation of the pollen record is furthermore based on pollen accumulation rate data. The pollen record and historic documents show similar trends in vegetation development. During the first phase (AD 1200-1412), the Lake Czechowskie area was still largely forested with Quercus, Carpinus and Pinus forests. Vegetation was more open during the second phase (AD 1412-1776), and reached maximum openness during the third phase (AD 1776-1905). Furthermore, intensified forest management led to a transformation from mixed to pine dominated forests during this period. Since the early 20th century, the forest cover increased again with dominance of the Scots pine in the stand. While pollen and historic data show similar trends, they differ substantially in the degree of openness during the four phases with pollen data commonly suggesting more open conditions. We discuss potential causes for this discrepancy, which include unsuitable parameters settings in REVEALS and unknown changes in forest structure. Using pollen accumulation data as a third proxy record we aim to identify the most probable causes. Finally, we discuss the observed vegetation change in relation the socio-economic development of the area. This study is a contribution to the Virtual Institute of Integrated Climate and Landscape Evolution Analysis - ICLEA- of the Helmholtz Association and National Science Centre, Poland (grant No. 2011/01/B/ST10

  2. Sexual Orientation Microaggressions: "Death by a Thousand Cuts" for Lesbian, Gay, and Bisexual Youth

    Science.gov (United States)

    Nadal, Kevin L.; Issa, Marie-Anne; Leon, Jayleen; Meterko, Vanessa; Wideman, Michelle; Wong, Yinglee

    2011-01-01

    In recent years, there has been a growth of literature examining the mental health impacts of microaggressions, which are defined as subtle forms of discrimination toward oppressed groups. The current study utilized a qualitative focus group method and directed content analysis to categorize several types of sexual orientation microaggressions…

  3. RUMD: A general purpose molecular dynamics package optimized to utilize GPU hardware down to a few thousand particles

    Directory of Open Access Journals (Sweden)

    Nicholas P. Bailey, Trond S. Ingebrigtsen, Jesper Schmidt Hansen, Arno A. Veldhorst, Lasse Bøhling, Claire A. Lemarchand, Andreas E. Olsen, Andreas K. Bacher, Lorenzo Costigliola, Ulf R. Pedersen, Heine Larsen, Jeppe C. Dyre, Thomas B. Schrøder

    2017-12-01

    Full Text Available RUMD is a general purpose, high-performance molecular dynamics (MD simulation package running on graphical processing units (GPU's. RUMD addresses the challenge of utilizing the many-core nature of modern GPU hardware when simulating small to medium system sizes (roughly from a few thousand up to hundred thousand particles. It has a performance that is comparable to other GPU-MD codes at large system sizes and substantially better at smaller sizes.RUMD is open-source and consists of a library written in C++ and the CUDA extension to C, an easy-to-use Python interface, and a set of tools for set-up and post-simulation data analysis. The paper describes RUMD's main features, optimizations and performance benchmarks.

  4. Is an Inuit Literary History Possible?

    Science.gov (United States)

    Martin, Keavy

    2010-01-01

    In 1921, the Greenlandic anthropologist Knud Rasmussen set out to travel twenty thousand miles by dog team across Inuit Nunaat--the Inuit homeland. During this three-year journey--the famous Fifth Thule Expedition--Rasmussen was struck by the similarities in the language and culture of Inuit communities across the entire Arctic. Considering the…

  5. Variability in terrigenous sediment supply offshore of the Rio de la Plata (Uruguay) recording the continental climatic history over the past 1200 years

    Science.gov (United States)

    Perez, L.; García-Rodríguez, F.; Hanebuth, T. J. J.

    2015-04-01

    The continental shelf adjacent to the Río de la Plata (RdlP) exhibits extremely complex hydrographic and ecological characteristics which are of great socio-economic importance. Since the long-term environmental variations related to the atmospheric (wind fields), hydrologic (freshwater plume), and oceanographic (currents and fronts) regimes are little known, the aim of this study is to reconstruct the changes in the terrigenous input into the inner continental shelf during the Late Holocene period (associated with the RdlP sediment discharge) and to unravel the climatic forcing mechanisms behind them. To achieve this, we retrieved a 10 m long sediment core from the RdlP mud depocenter at a depth of 57 m (GeoB 13813-4). The radiocarbon age control indicated an extremely high sedimentation rate of 0.8 cm per year, encompassing the past 1200 years (750-2000 AD). We used element ratios (Ti / Ca, Fe / Ca, Ti / Al, Fe / K) as regional proxies for the fluvial input signal, and the variations in relative abundance of salinity-indicative diatom groups (freshwater vs. marine-brackish) to assess the variability in terrigenous water and sediment discharge. Ti / Ca, Fe / Ca, Ti / Al, Fe / K and the freshwater diatom group showed the lowest values between 850 and 1300 AD, while the highest values occurred between 1300 and 1850 AD. The variations in the sedimentary record can be attributed to such regional and global climatic episodes as the Medieval Climatic Anomaly (MCA) and the Little Ice Age (LIA), both of which had a significant impact on rainfall and wind patterns over the region. During the MCA, a northward migration of the Intertropical Confluence Zone (ITCZ) could explain the lowest element ratios (indicative of a lower terrigenous input) and a marine-dominated diatom record, both indicative of a reduced RdlP freshwater plume. In contrast during the LIA, the southward migration of the ITCZ accompanied by El Niño-like state conditions may have led to an expansion of

  6. Variability in terrigenous sediment supply offshore of the Río de la Plata (Uruguay) recording the continental climatic history over the past 1200 years

    Science.gov (United States)

    Perez, Laura; García-Rodríguez, Felipe; Hanebuth, Till J. J.

    2016-03-01

    The continental shelf adjacent to the Río de la Plata (RdlP) exhibits extremely complex hydrographic and ecological characteristics which are of great socioeconomic importance. Since the long-term environmental variations related to the atmospheric (wind fields), hydrologic (freshwater plume), and oceanographic (currents and fronts) regimes are little known, the aim of this study is to reconstruct the changes in the terrigenous input into the inner continental shelf during the late Holocene period (associated with the RdlP sediment discharge) and to unravel the climatic forcing mechanisms behind them. To achieve this, we retrieved a 10 m long sediment core from the RdlP mud depocenter at 57 m water depth (GeoB 13813-4). The radiocarbon age control indicated an extremely high sedimentation rate of 0.8 cm per year, encompassing the past 1200 years (AD 750-2000). We used element ratios (Ti / Ca, Fe / Ca, Ti / Al, Fe / K) as regional proxies for the fluvial input signal and the variations in relative abundance of salinity-indicative diatom groups (freshwater versus marine-brackish) to assess the variability in terrigenous freshwater and sediment discharges. Ti / Ca, Fe / Ca, Ti / Al, Fe / K and the freshwater diatom group showed the lowest values between AD 850 and 1300, while the highest values occurred between AD 1300 and 1850. The variations in the sedimentary record can be attributed to the Medieval Climatic Anomaly (MCA) and the Little Ice Age (LIA), both of which had a significant impact on rainfall and wind patterns over the region. During the MCA, a weakening of the South American summer monsoon system (SAMS) and the South Atlantic Convergence Zone (SACZ), could explain the lowest element ratios (indicative of a lower terrigenous input) and a marine-dominated diatom record, both indicative of a reduced RdlP freshwater plume. In contrast, during the LIA, a strengthening of SAMS and SACZ may have led to an expansion of the RdlP river plume to the far north, as

  7. Macroalgal diversity along an inshore-offshore environmental gradient in the Jakarta Bay - Thousand Islands reef complex, Indonesia

    Science.gov (United States)

    Draisma, Stefano G. A.; Prud'homme van Reine, Willem F.; Herandarudewi, Sekar M. C.; Hoeksema, Bert W.

    2018-01-01

    The Jakarta Bay - Thousand Islands reef complex extends to more than 80 km in northwest direction from the major conurbation Jakarta (Indonesia) along a pronounced inshore to offshore environmental gradient. The present study aims to determine to what extent environmental factors can explain the composition of macroalgal communities on the reefs off Jakarta. Therefore, the presence-absence of 67 macroalgal taxa was recorded for 27 sampling sites along the inshore-offshore disturbance gradient and analysed with substrate variables and water quality variables. The macroalgal richness pattern matches the pattern of other reef taxa. The 27 sites could be assigned to one of four geographical zones with 85% certainty based on their macroalgal taxon assemblages. These four zones (i.e., Jakarta Bay and, respectively, South, Central, and North Thousand Islands) had significantly different macroalgal assemblages, except for the North and South zones. Along the nearshore gradient there was a greater shift in taxon composition than within the central Thousand Islands. The patterns of ten habitat and water quality variables resembled the macroalgal diversity patterns by 56%. All ten variables together explained 69% of the variation in macroalgal composition. Shelf depth, % sand cover, gelbstoff/detrital material, chlorophyll a concentration, seawater surface temperature, and % dead coral cover were the best predictors of seaweed flora composition. Furthermore, 44 macroalgal species represented new records for the area. The present study provides important baseline data of macroalgae in the area for comparison in future biodiversity assessments in the area and elsewhere in the region.

  8. Physical Activity Frequency on the 10-Year Acute Coronary Syndrome (ACS) Prognosis; The Interaction With Cardiovascular Disease History and Diabetes Mellitus: The GREECS Observational Study.

    Science.gov (United States)

    Papataxiarchis, Evangelos; Panagiotakos, Demosthenes B; Notara, Venetia; Kouvari, Matina; Kogias, Yannis; Stravopodis, Petros; Papanagnou, George; Zombolos, Spyros; Mantas, Yannis; Pitsavos, Christos

    2016-10-01

    The association between physical activity, diabetes mellitus (DM), and long-term acute coronary syndrome (ACS) prognosis was evaluated. The GREECS study included 2,172 consecutive ACS patients from six Greek hospitals (2003-2004). In 2013-2014, a 10-year follow up was performed with 1,918 patients. Physical activity was categorized in never, rarely (monthly basis), 1-2 and ≥ 3 times/week. Multi-adjusted analysis revealed that 1-2 and ≥ 3 times/week vs. no physical activity had a protective effect on ACS incidence (OR = 0.63 95% CI 0.38, 1.05) and (OR = 0.63 95% CI 0.40, 0.99) respectively, only in patients without prior baseline CVD event. In a subgroup analysis, with DM as strata in these patients, engagement in physical activity (i.e., 1-2 times/week) had a significant protective effect among patients with diabetes (OR = 0.51, 95% CI 0.27, 0.96, p = .037). These findings revealed the beneficial role of exercise in secondary ACS prevention, even in DM patients. Public health-oriented policies should incorporate regular physical activity as a key protective factor in disease prognosis.

  9. Testosterone-receptor positive hepatocellular carcinoma in a 29-year old bodybuilder with a history of anabolic androgenic steroid abuse: a case report.

    Science.gov (United States)

    Solbach, Philipp; Potthoff, Andrej; Raatschen, Hans-Jürgen; Soudah, Bisharah; Lehmann, Ulrich; Schneider, Andrea; Gebel, Michael J; Manns, Michael P; Vogel, Arndt

    2015-05-20

    Continuous use of anabolic androgenic steroid in high-doses is associated with substantial health risks, including hepatocellular adenoma. Malignant transformation from hepatocellular adenoma to hepatocellular carcinoma after anabolic androgenic steroid abuse has been rarely reported. The morphological distinction of adenoma from well-differentiated hepatocellular carcinoma is challenging and requires elaborated imaging techniques and histology. We report about a 29-year old male professional bodybuilder who presented with mid-epigastric pain at the emergency unit. Ultrasound showed a severe hepatomegaly with multiple lesions. Contrast-enhanced ultrasound revealed a heterogeneous pattern with signs of hepatocellular carcinoma. CT scan of the abdomen confirmed multiple hypervascular lesions and central areas of necrosis without contrast enhancement. Subsequent diagnostics included fine needle aspiration (FNA) of suspicious lesions and mini-laparoscopy to establish the diagnosis of a β-catenin and testosterone-receptor positive hepatocellular carcinoma embedded in multiple adenomas. The patient was subsequently treated by liver transplantation and remains tumor-free 27 month after surgery. Hepatocellular carcinoma occurring in association with anabolic androgenic steroid abuse should sensitize physicians and especially professional bodybuilders for the harmful use of high doses of steroids.

  10. Natural history of Helicobacter pylori infection in childhood: eight-year follow-up cohort study in an urban community in northeast of Brazil.

    Science.gov (United States)

    Queiroz, Dulciene M; Carneiro, Jessica G; Braga-Neto, Manuel B; Fialho, Andrea B C; Fialho, Andre M; Goncalves, Maria H B; Rocha, Gifone A; Rocha, Andreia M C; Braga, Lucia L B

    2012-02-01

    Helicobacter pylori infection is acquired predominantly in childhood. There is also evidence that children loss the infection. Therefore, factors that account for children remain infected need to be investigated because once established the infection persists throughout the life unless treated. This study aimed to evaluate the H. pylori infection in children of a low-income community at baseline and 8years later to determine the predictor factors linked to the maintenance, acquisition, and loss of the infection using regression models of generalized estimating equations. H. pylori status was determined by (13) C-urea breath test. Data from 37.7% (133/353) of the children were available. No difference between the characteristics of the included and nonincluded children was observed. The prevalence of infection increased from 53.4 to 64.7%. Thirty-nine children (29.3%) remained noninfected, 47.4% remained infected, 17.3% became infected, and 6.0% lost the infection. Factors associated with to remain infected compared with to remain noninfected included the age, increased number of children in the household, and the use of well water instead of municipal water. The acquisition of the infection was associated with the male gender. Factors linked to remain and to gain H. pylori infection in a poor region were increased number of children in the household and the male gender. Also, the acquisition rates were higher than the loss rates, which lead to an increase in the infection prevalence with age. © 2011 Blackwell Publishing Ltd.

  11. History of echinostomes (Trematoda).

    Science.gov (United States)

    Toledo, Rafael; Radev, Valentin; Kanev, Ivan; Gardner, Scott L; Fried, Bernard

    2014-10-01

    Echinostomatidae (Trematoda) is the largest family within the class Trematoda. Members of this family have been studied for many years in relation to their utility as basic research models in biodiversity and systematics and also as experimental models in parasitology since they offer many advantages. Echinostomes have contributed significantly to numerous developments in many areas studied by parasitologists and experimental biologists. In this review, we examine the history of the echinostomebased studies from the beginnings to the present. For this purpose, we have divided the history of echinostomes into four periods (i.e. 18(th) and 19(th) centuries, first half of the 20(th) century, second half of the 20(th) century and the late 20(th) and 21(th) century) according to the types of studies performed in each of them. Moreover, we also briefly review the history of echinostome infections in humans.

  12. User Interface History

    DEFF Research Database (Denmark)

    Jørgensen, Anker Helms; Myers, Brad A

    2008-01-01

    User Interfaces have been around as long as computers have existed, even well before the field of Human-Computer Interaction was established. Over the years, some papers on the history of Human-Computer Interaction and User Interfaces have appeared, primarily focusing on the graphical interface era...... and early visionaries such as Bush, Engelbart and Kay. With the User Interface being a decisive factor in the proliferation of computers in society and since it has become a cultural phenomenon, it is time to paint a more comprehensive picture of its history. This SIG will investigate the possibilities...... of  launching a concerted effort towards creating a History of User Interfaces. ...

  13. Criminal Justice History

    Directory of Open Access Journals (Sweden)

    Thomas Krause

    2005-01-01

    Full Text Available This review article discusses studies on the history of crime and the criminal law in England and Ireland published during the last few years. These reflect the ›history of crime and punishment‹ as a more or less established sub-discipline of social history, at least in England, whereas it only really began to flourish in the german-speaking world from the 1990s onwards. By contrast, the legal history of the criminal law and its procedure has a strong, recently revived academic tradition in Germany that does not really have a parallel in the British Isles, whose legal scholars still evidence their traditional reluctance to confront penal subjects.

  14. History of Korean Neurosurgery.

    Science.gov (United States)

    Hwang, Sung-nam

    2015-08-01

    The year 2012 was the 50th anniversary of the Korean Neurosurgical Society, and in 2013, the 15th World Congress of Neurosurgery took place in Seoul, Korea. Thus, it is an appropriate occasion to introduce the world to the history of the Korean Neurosurgical Society and the foundation, development, and growth of Korean neurosurgery. Historical materials and pictures were collected and reviewed from the history book and photo albums of the Korean Neurosurgical Society. During the last 50 years, the Korean Neurosurgical Society and Korean neurosurgery have developed and grown enormously not only in quantity but also in quality. In every aspect, the turning point from the old to the new era of the Korean Neurosurgical Society and Korean neurosurgery was the year 1980. Copyright © 2015. Published by Elsevier Inc.

  15. [(Neurological CPC-59). A 65-year-old man with a history of gastric cancer who presented progressive loss of vision, memory loss and consciousness disturbance].

    Science.gov (United States)

    Nohara, C; Matsumine, H; Suzuki, K; Saito, A; Ohtaka, M; Mori, H; Suda, K; Kondo, T; Hayakawa, M; Kanai, J; Mizuno, Y

    1997-11-01

    We report a 65-year-old man with progressive loss of vision and consciousness disturbance. The patient was well until his age of 63 when he was found to have a gastric cancer. He was treated by the tumor resection and chemotherapy; he was apparently well, but hepatic metastases were found in the next year (1996). In June, 1996, he noted an onset of blurred vision more on the left. He was admitted to the ophthalmology service of our hospital on July 14, 1996. His vision was 0.8 on the right and 0.15 on the left. He was treated with oral prednisolone with slight improvement. He was also found to have IgM kappa-type monoclonal gammopathy; Bence-Jones protein was positive and a bone marrow aspiration revealed that approximately 10% of bone marrow cells were atypical plasma cells. His vision had progressively got worse and he became blind by the end of October 1996. A chest X-ray and cranial CT scan revealed multiple abnormal nodular densities. In the middle of November 1996, he became confused, disoriented and agitated. His mental symptoms had progressively became worse, and a neurologic consultation was asked on December 10, 1996. Neurologic examination revealed that he was somnolent with decreased attention to his surroundings. He showed marked disorientation and memory loss. Higher cerebral functions appeared intact. He was able to recognize only light and dark. Pupils were moderately dilated with very sluggish light reflex remained. Vertical gaze was moderately restricted and horizontal nystagmus was noted upon left and right lateral gaze. The remaining of the neurologic examination were unremarkable. General physical examination revealed hepatosplenomegaly; the liver was palpable by 3 cm below the right costal margin. Laboratory examination revealed anemia (Hb10.1 g/dl) and thrombocytopenia (43,000/microliter). A cranial CT scan and MRI revealed a mass lesion in involving the chiasmatic and bilateral hypothalamic areas. The tumor showed intense homogeneous

  16. About the science-theoretical measuring of history of revolutionary shocks in Russia (to the 100 year of February and October, 1917

    Directory of Open Access Journals (Sweden)

    Andrey V. Ishin

    2017-01-01

    Full Text Available The article is devoted the comprehension of the science-theoretical tool of research of revolutionary shocks in Russia. The 100-years-old anniversary of revolutionary shocks in Russia pulls out before researchers the vital task of complex comprehension of reasons, character and consequences of revolution. Scientific tasks which stood before the scientists of soviet epoch lay mainly inplane illumination of event of revolution and Civil war as displays of fight of «leading revolutionary class» — proletariat at the head with bolshevist communist party with «regressive classes» — bourgeoisie, squires, clergy, the «kulak». Within the framework of this main approach, researchers succeeded to form the fully integral scientific picture of social and political conflict of 1917-1922 years, on the whole to expose his motive forces, leading political actors, to trace the dynamics of events.However and presently to a full degree the task of comprehensive scientific analysis of structural-functional features of becoming and evolution of organs of power saves the actuality, which functioned within the framework of the different political modes, including modes of antibolshevist orientation. The important element of search is an exposure of specific of mutual relations of public institutions, basic directions of policy, historical factors which stipulated acceptance and practical realization of important administrative decisions.Іnstitucional approach must organically complement dominant to this day in scientific literature historical-event approach. Institucional approach consists in that a look to the social and political process is inplane not «from» (as in the historical-event measuring outside, and, vice versa, «from within». In obedience to this approach, research attention applies foremost on subsoil and on organization of administrative mechanisms, internal logic of acceptance both key and, on the face of it, second-rate decisions

  17. Maternal age, alcohol abuse history, and quality of parenting as moderators of the effects of prenatal alcohol exposure on 7.5-year intellectual function.

    Science.gov (United States)

    Jacobson, Sandra W; Jacobson, Joseph L; Sokol, Robert J; Chiodo, Lisa M; Corobana, Raluca

    2004-11-01

    In contrast to the extensive literature documenting IQ deficits in patients with fetal alcohol syndrome, effects on IQ have not generally been reported for children with alcohol-related neurodevelopmental disorder (ARND). This study examined the role of maternal age, MAST, and quality of parenting in moderating the effects of prenatal alcohol exposure on the WISC-III IQ test in moderate-to-heavily exposed children. A total of 337 inner-city African American children whose mothers were recruited prenatally were administered the WISC-III at 7.5 years. Alcohol exposure was assesed with a timeline follow-back interview administered at every prenatal clinic visit. Moderating effects of the three risk factors were examined by adding interaction terms to regression analyses and dichotomizing the moderators and performing separate regressions on the two groups. Prenatal alcohol exposure was related to WISC-III Freedom from Distractibility but not to Full Scale IQ for the sample as a whole. However, among children born to older mothers, an alcohol effect emerged on Full Scale IQ and five of seven composite IQ scores. Similarly, adverse effects were seen among children of MAST-positive mothers and children whose parents provided less optimal cognitive stimulation. Each additional ounce of absolute alcohol consumed per day during pregnancy was associated with a 2.9-point decrease in Full Scale IQ and a 5.6-point decrement on Freedom from Distractibility. This study is the first to demonstrate IQ effects among children with ARND born to older and MAST-positive mothers, particularly in relation to first-trimester drinking. These findings suggest that there are subgroups of more vulnerable and severely affected children whose intellectual performance is compromised. A moderate- to heavy-drinking mother who has given birth to an unaffected child when she was younger needs to be warned that her risk of having an adversely affected child increases as she grows older.

  18. 8800 years of high-altitude vegetation and climate history at the Rutor Glacier forefield, Italian Alps. Evidence of middle Holocene timberline rise and glacier contraction

    Science.gov (United States)

    Badino, Federica; Ravazzi, Cesare; Vallè, Francesca; Pini, Roberta; Aceti, Amelia; Brunetti, Michele; Champvillair, Elena; Maggi, Valter; Maspero, Francesco; Perego, Renata; Orombelli, Giuseppe

    2018-04-01

    Sedimentary archives at or near the timberline ecotone in Alpine glaciated areas contain records to study Holocene climate change and the interplay between climate, ecosystems, and humans. We focused on records of timberline and glacier oscillations in the Rutor Glacier forefield (Western Italian Alps) in the last 8800 years. Human activity in this area was negligible for most of the Holocene. We adopted an integrative stratigraphic approach including proxies for glacier advance and timberline estimation, sedimentary events, and reconstructed temperatures. Changes in timberline ecotone correlate to climate until the Middle Ages. Pollen-stratigraphic evidence of a primary plant succession highlights a lag beween local deglaciation and the first reliable 14C age. The radiocarbon chronology points to a prolonged phase of glacier contraction between 8.8 and 3.7 ka cal BP. Even later the glacier remained within its LIA limits. Between 8.4 and 4 ka cal BP MAT-inferred TJuly fluctuated near 12.4 °C, ca. 3.1 °C higher than today. During this period, a Pinus cembra forest belt grew at 2600 m asl with an upper limit of tree groves placed 434 ± 310 m above the current open forest limit. This Holocene phase of thermal maximum ended between 3.98 and 3.51 ± 70 ka cal BP and with a substantial rearrangement of forest composition; temperature reconstruction shows a decrease of 1.8 °C. This climate deterioration concluded the Subboreal thermal optimum, mirroring glacial advances widely documented in the Alps. The Rutor Glacier advanced at ca. AD 1093 ± 65, and remained inside the LIA maximum extent. The LIA started since AD 1594, and culminated between AD 1751 and 1864.

  19. Profissão nutricionista: 70 anos de história no Brasil Profession of dietician: 70 years of history in Brazil

    Directory of Open Access Journals (Sweden)

    Francisco de Assis Guedes de Vasconcelos

    2011-08-01

    Full Text Available OBJETIVO: Realizar análise histórica dos 70 anos da profissão de nutricionista no Brasil, procurando analisar a expansão do número de cursos de graduação em nutrição e de nutricionistas no país e a identidade do nutricionista brasileiro no contexto atual. MÉTODOS: A base empírica foi constituída pelas estatísticas do número de profissionais e de cursos disponibilizadas pelo Conselho Federal de Nutricionistas e pelos dados da pesquisa "Inserção Profissional dos Nutricionistas no Brasil", realizada em 2005, pelo Conselho Federal de Nutricionistas. RESULTADOS: Em agosto de 2009, existiam 391 Cursos de Nutrição no Brasil (324 privados e 67 públicos, com 49 185 vagas anuais. Em junho de 2009, existiam 60 554 nutricionistas registrados no País, perfazendo uma relação de um nutricionista para cada 3 162 habitantes. De acordo com pesquisa do Conselho Federal de Nutricionistas, em 2005, o nutricionista brasileiro apresentava o seguinte perfil: 96,5% do sexo feminino; 79,4% entre 20 e 40 anos; 53,6% solteiros; 79,1% de cor branca; 41,7% atuando em nutrição clínica; 32,2% em alimentação coletiva; 9,4% em ensino (docência; 8,8% em saúde coletiva; 4,1% em nutrição esportiva e 3,7% em indústria de alimentos. CONCLUSÃO: A análise aponta intensa elevação do número de cursos e de profissionais e diversificação das áreas de atuação do nutricionista. Além das sete grandes áreas de atuação reconhecidas pelo Conselho Federal de Nutricionistas, observa-se dentro delas um amplo processo de divisão dos seus objetos de trabalho. É provável que, nos próximos anos, em função do lançamento de maior número de profissionais, ocorra uma redistribuição geográfica dos nutricionistas, modificações no mercado de trabalho e áreas de atuação profissional.OBJECTIVE: This study made a historical analysis of the 70 years of the profession of dietician in Brazil, attempted to analyze the increase in the number of

  20. Phylogeographic history of grey wolves in Europe.

    Science.gov (United States)

    Pilot, Małgorzata; Branicki, Wojciech; Jedrzejewski, Włodzimierz; Goszczyński, Jacek; Jedrzejewska, Bogumiła; Dykyy, Ihor; Shkvyrya, Maryna; Tsingarska, Elena

    2010-04-21

    While it is generally accepted that patterns of intra-specific genetic differentiation are substantially affected by glacial history, population genetic processes occurring during Pleistocene glaciations are still poorly understood. In this study, we address the question of the genetic consequences of Pleistocene glaciations for European grey wolves. Combining our data with data from published studies, we analysed phylogenetic relationships and geographic distribution of mitochondrial DNA haplotypes for 947 contemporary European wolves. We also compared the contemporary wolf sequences with published sequences of 24 ancient European wolves. We found that haplotypes representing two haplogroups, 1 and 2, overlap geographically, but substantially differ in frequency between populations from south-western and eastern Europe. A comparison between haplotypes from Europe and other continents showed that both haplogroups are spread throughout Eurasia, while only haplogroup 1 occurs in contemporary North American wolves. All ancient wolf samples from western Europe that dated from between 44,000 and 1,200 years B.P. belonged to haplogroup 2, suggesting the long-term predominance of this haplogroup in this region. Moreover, a comparison of current and past frequencies and distributions of the two haplogroups in Europe suggested that haplogroup 2 became outnumbered by haplogroup 1 during the last several thousand years. Parallel haplogroup replacement, with haplogroup 2 being totally replaced by haplogroup 1, has been reported for North American grey wolves. Taking into account the similarity of diets reported for the late Pleistocene wolves from Europe and North America, the correspondence between these haplogroup frequency changes may suggest that they were associated with ecological changes occurring after the Last Glacial Maximum.