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Sample records for thomsen elin sundgaard

  1. Acrimony needs / Elin Kard

    Index Scriptorium Estoniae

    Kard, Elin

    2006-01-01

    "Acrimony needs" on Elin Kardi ühe maali pealkiri Tallinna Kunstihoones 8.04.-28.05.2006 eksponeeritud Elin Kardi, Marko Mäetamme, Marco Laimre ja Andres Tali ühisnäitusel "Vägivald ja propaganda". Töö viitab Taani riigilipu kaudu 2006. a. alguses lahvatanud nn. karikatuuriskandaalile, kui ajaleht Jyllands-Posten avaldas pilapildid prohvet Muhamedist, mis põhjustasid pahameeletormi moslemimaailmas

  2. Analysis of Thomsen parameters for finely layered VTI media

    International Nuclear Information System (INIS)

    Berryman, J.G.; Berge, P.A.

    1997-01-01

    The range of Thomsen's anisotropy parameters ε and δ for vertical transversely isotropic (VTI) media when the anisotropy is due to fine layering of isotropic elas-tic materials is considered. We show that ε lies in the range -3/8 ≤ ε ≤ 1/2 v p 2 > p-2 >-1 for finely layered media having constant density; smaller positive and all negative values of ε occur for media with large fluctuations in the Lamacute e parameter λ We show that sign(δ) = sign ( p -2 > - s -2 > s 2 /v p 2 >) for constant density media, so δ can be either positive or negative. Among all theoretically possible random media, posi-tive and negative δ are equally likely in finely layered media limited to two types of constituent layers. Lay-ered media having large fluctuations in Lamacute e λ are the ones most likely to have positive δ. Since Gassmann's results for fluid-saturated porous media show that the effects of fluids influence only the λ Lamacute e constant, not the shear modulus μ, these results suggest that positive δ occurring together with positive but small ε may be indicative of changing fluid content in layered earth

  3. The Thomsen-Friedenreich (T) simple mucin-type carbohydrate antigen in salivary gland carcinomas

    DEFF Research Database (Denmark)

    Therkildsen, M H; Mandel, U; Christensen, M

    1995-01-01

    The simple mucin-type T (Thomsen-Friedenreich) antigen is a marker of carcinomas, and has been related to aggressiveness of malignant tumours. We studied the expression of T, sialosyl-T, A and H blood group antigens in salivary gland carcinomas. The aim was to study whether the tumours, based on ...

  4. E-line: A new crystal collimator beam line for source size measurements at CHESS

    International Nuclear Information System (INIS)

    White, Jeffrey A.; Revesz, Peter; Finkelstein, Ken

    2007-01-01

    A new X-ray beam line has been constructed at cornell high energy synchrotron source (CHESS) to measure the vertical and horizontal source size of the positron particle beam. The cornell laboratory of elementary particle physics (LEPP) operates the storage ring (CESR) for X-ray generation for the CHESS user community by circulating electrons and their antimatter counterpart positrons in counter-rotating beams. As the laboratory reduces the emittances of particle beams to increase X-ray brilliance, there has been an increasing need for diagnostic tools to measure and monitor source size. A beam line front end that accesses the positron synchrotron light has been fitted with an experimental chamber and apparatus of compact design capable of horizontal and vertical source size measurement using the 'crystal collimator' technique, and an additional setup for vertical beam position monitoring using a luminescence-based X-ray video beam position monitoring system. The crystal collimators each consist of two Si(2 2 0) crystals in a dispersive (+,+) arrangement that diffract X-rays to a fluorescent material coated on a view port observed with a CCD camera. Measurements of the positron vertical beam size using the crystal collimation method at E-line are compared with measurements of visible synchrotron light at a remotely located dedicated port on the storage ring

  5. Julius Thomsen and 19th-century speculations on the complexity of atoms

    DEFF Research Database (Denmark)

    Kragh, Helge

    1982-01-01

    In the history of chemistry, the Danish chemist Julius Thomsen (1826-1909) is best known for his contributions to thermochemistry. Throughout his life, he was a pronounced atomist and a tireless advocate of neo-Proutian views as to the constitution of matter. On many occasions, especially in his ...... as to the constitution of matter, the periodic system and the noble gases, may be seen as typical of this vigorous trend in fin de si cle chemistry....

  6. The Thomsen-Friedenreich (T) simple mucin-type carbohydrate antigen in salivary gland carcinomas

    DEFF Research Database (Denmark)

    Therkildsen, M H; Mandel, U; Christensen, M

    1995-01-01

    The simple mucin-type T (Thomsen-Friedenreich) antigen is a marker of carcinomas, and has been related to aggressiveness of malignant tumours. We studied the expression of T, sialosyl-T, A and H blood group antigens in salivary gland carcinomas. The aim was to study whether the tumours, based...... on the expression of these structures, could be divided into new diagnostic groups that may later show prognostic significance. Formalin fixed paraffin-embedded tissue sections from 77 salivary gland carcinomas of different histological types were studied using immunohistology and monoclonal antibodies (MAbs...

  7. Development, Characterization, and Immunotherapeutic Use of Peptide Mimics of the Thomsen-Friedenreich Carbohydrate Antigen

    Directory of Open Access Journals (Sweden)

    Jamie Heimburg-Molinaro

    2009-08-01

    Full Text Available The tumor-associated carbohydrate Thomsen-Friedenreich antigen (TF-Ag; Galß1-3GalNAcα-O-Ser/Thr is overexpressed on the cell surface of several types of tumor cells, contributing to cancer cell adhesion and metastasis to sites containing TF-Ag-binding lectins. A highly specific immunoglobulin G3 monoclonal antibody (Ab developed to TF-Ag (JAA-F11 impedes TF-Ag binding to vascular endothelium, blocking a primary metastatic step and providing a survival advantage. In addition, in patients, even low levels of antibodies to TF-Ag seem to improve prognosis; thus, it is expected that vaccines generating antibodies toward TF-Ag would be clinically valuable. Unfortunately, vaccinations with protein conjugates of carbohydrate tumor-associated Ags have induced clinically inadequate immune responses. However, immunization using peptides that mimic carbohydrate Ags such as Lewis has resulted in both Ab and T-cell responses. Here, we tested the hypothesis that vaccinations with unique TF-Ag peptide mimics may generate immune responses to TF-Ag epitopes on tumor cells, useful for active immunotherapy against relevant cancers. Peptide mimics of TF-Ag were selected by phage display biopanning using JAA-F11 and rabbit anti-TF-Ag Ab and were analyzed in vitro to confirm TF-Ag peptide mimicry. In vitro, TF-Ag peptide mimics bound to TF-Ag-specific peanut agglutinin and blocked TF-Ag-mediated rolling and stable adhesion of cancer cells to vascular endothelium. In vivo, the immunization with TF-Ag-mimicking multiple antigenic peptides induced TFAg- reactive Ab production. We propose that this novel active immunotherapy approach could decrease tumor burden in cancer patients by specifically targeting TF-Ag-positive cancer cells and blocking metastasis.

  8. Preclinical Analysis of JAA-F11, a Specific Anti–Thomsen-Friedenreich Antibody via Immunohistochemistry and In Vivo Imaging

    Directory of Open Access Journals (Sweden)

    Loukia G. Karacosta

    2018-04-01

    Full Text Available The tumor specificity of JAA-F11, a novel monoclonal antibody specific for the Thomsen-Friedenreich cancer antigen (TF-Ag-alpha linked, has been comprehensively studied by in vitro immunohistochemical (IHC staining of human tumor and normal tissue microarrays and in vivo biodistribution and imaging by micro-positron emission tomography imaging in breast and lung tumor models in mice. The IHC analysis detailed herein is the comprehensive biological analysis of the tumor specificity of JAA-F11 antibody performed as JAA-F11 is progressing towards preclinical safety testing and clinical trials. Wide tumor reactivity of JAA-F11, relative to the matched mouse IgG3 (control, was observed in 85% of 1269 cases of breast, lung, prostate, colon, bladder, and ovarian cancer. Staining on tissues from breast cancer cases was similar regardless of hormonal or Her2 status, and this is particularly important in finding a target on the currently untargetable triple-negative breast cancer subtype. Humanization of JAA-F11 was recently carried out as explained in a companion paper “Humanization of JAA-F11, a Highly Specific Anti–Thomsen-Friedenreich Pancarcinoma Antibody and In Vitro Efficacy Analysis” (Neoplasia 19: 716-733, 2017, and it was confirmed that humanization did not affect chemical specificity. IHC studies with humanized JAA-F11 showed similar binding to human breast tumor tissues. In vivo imaging and biodistribution studies in a mouse syngeneic breast cancer model and in a mouse-human xenograft lung cancer model with humanized 124I- JAA-F11 construct confirmed in vitro tumor reactivity and specificity. In conclusion, the tumor reactivity of JAA-F11 supports the continued development of JAA-F11 as a targeted cancer therapeutic for multiple cancers, including those with unmet need.

  9. Miotonia de Thomsen: Considerações sobre sua terapêutica

    Directory of Open Access Journals (Sweden)

    Paulo Pinto Pupo

    1946-03-01

    com os trabalhos de Wölf, e que tem sido muito pouco discutida na literatura. Apresentam um caso de miotonia de Thomsen, em rapaz de 21 anos, 5.° entre 8 irmãos sadios, brasileiro descendente de italianos, que não tem qualquer outro antecedente mórbido pessoal ou familial. Sua miotonia é isolada, estacionária e evidente desde os primeiros anos de idade. Não tem qualquer moléstia para o lado dos aparelhos da vida vegetativa. Não há fenômenos miotônicos na musculatura cardíaca ou ocular. Não há distúrbios outros neurológicos, neurovegetativos ou psíquicos. A ação benéfica da quinina se fêz sempre com 1,0 gr. de sulfato de quinina dado por via oral. A miotonia desaparecia sempre, progressivamente, de 15 a 45 minutos após ingestão, e só voltava a reaparecer depois de 10 a 12 horas. A tolerância à quinina foi perfeita. Só foi possível se fazer provas dessa espécie dez dias seguidos, devido à dificuldade em obter quinina na época atual. A miotonia, e a ação antimiotônica da quinina, foram abundantemente documentadas com miogramas, ergogramas, eletromiogramas e filme cinematográfico. Concluem, indicando que o problema atual do tratamento da miotonia está somente em encontrar a dose mínima do sal de quinina que seja suficiente para eliminar o fenômeno miotônico e tolerável pelo paciente em administração prolongada. Aventa a hipótese de se fazer o tratamento com transfusão do sôro de doentes com miastenia grave e, por fim, relata já estar empregando os sais de quinina na terapêutica da cãibra dos esportistas.

  10. Inhibition of Spontaneous Breast Cancer Metastasis by Anti—Thomsen-Friedenreich Antigen Monoclonal Antibody JAA-F11

    Directory of Open Access Journals (Sweden)

    Jamie Heimburg

    2006-11-01

    Full Text Available Thomsen-Friedenreich antigen (TF-Ag is expressed in many carcinomas, including those of the breast, colon, bladder, prostate. TF-Ag is important in adhesion and metastasis and as a potential immunotherapy target. We hypothesized that passive transfer of JAAF11, an anti -TF-Ag monoclonal antibody, may create a survival advantage for patients with TIF-Ag -expressing tumors by cytotoxicity, blocking of tumor cell adhesion, inhibition of metastasis. This was tested using in vitro models of tumor cell growth; cytotoxicity assays; in vitro, ex vivo, in vivo models of cancer metastasis; and, finally, in vivo effects in mice with metastatic breast cancer. Unlike some anti-TF-Ag antibodies, JAA-F11 did not enhance breast carcinoma cell growth. JAA-F11 did not induce the killing of 4T1 tumor cells through complement-dependent cytotoxicity or apoptotic mechanisms. However, JAA-F11 blocked the stages of metastasis that involve the adhesion of human breast carcinoma cells to human endothelial cells (human umbilical vein endothelial cells and human bone marrow endothelial cells 60 in in vitro static adhesion models, in a perfused ex vivo model, in murine lung vasculature in an in vivo metastatic deposit formation assay. JAA-F11 significantly extended the median survival time of animals bearing metastatic 4T1 breast tumors and caused a > 50% inhibition of lung metastasis.

  11. Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and In Vitro Efficacy Analysis

    Directory of Open Access Journals (Sweden)

    Swetha Tati

    2017-09-01

    Full Text Available JAA-F11 is a highly specific mouse monoclonal to the Thomsen-Friedenreich Antigen (TF-Ag which is an alpha-O-linked disaccharide antigen on the surface of ~80% of human carcinomas, including breast, lung, colon, bladder, ovarian, and prostate cancers, and is cryptic on normal cells. JAA-F11 has potential, when humanized, for cancer immunotherapy for multiple cancer types. Humanization of JAA-F11, was performed utilizing complementarity determining regions grafting on a homology framework. The objective herein is to test the specificity, affinity and biology efficacy of the humanized JAA-F11 (hJAA-F11. Using a 609 target glycan array, 2 hJAA-F11 constructs were shown to have excellent chemical specificity, binding only to TF-Ag alpha-linked structures and not to TF-Ag beta-linked structures. The relative affinity of these hJAA-F11 constructs for TF-Ag was improved over the mouse antibody, while T20 scoring predicted low clinical immunogenicity. The hJAA-F11 constructs produced antibody-dependent cellular cytotoxicity in breast and lung tumor lines shown to express TF-Ag by flow cytometry. Internalization of hJAA-F11 into cancer cells was also shown using a surface binding ELISA and confirmed by immunofluorescence microscopy. Both the naked hJAA-F11 and a maytansine-conjugated antibody (hJAA-F11-DM1 suppressed in vivo tumor progression in a human breast cancer xenograft model in SCID mice. Together, our results support the conclusion that the humanized antibody to the TF-Ag has potential as an adjunct therapy, either directly or as part of an antibody drug conjugate, to treat breast cancer, including triple negative breast cancer which currently has no targeted therapy, as well as lung cancer.

  12. Información relevante que pasa a ser anecdótica: aerinita en las pinturas murales románicas de San Martín de Elines (Cantabria

    Directory of Open Access Journals (Sweden)

    M. Rosa Tera Saavedra

    2015-12-01

    Full Text Available Ante la dificultad de consultar datos materiales y analíticas provenientes de intervenciones existentes relacionadas con el Patrimonio Cultural, el presente artículo plantea la necesidad de establecer parámetros normalizados y accesibles que aglutinen información de memorias técnicas. Como ejemplo de la funcionalidad que podría derivarse de esta propuesta se analiza cómo podría beneficiar su uso en el caso de las pinturas románicas de San Martín de Elines (Cantabria cuya analítica de materiales presenta dos parámetros fuera del contexto geográfico donde están ubicadas y que las relaciona matéricamente con las pinturas románicas del Valle del Boí.

  13. Red blood cell Thomsen-Friedenreich antigen expression and galectin-3 plasma concentrations in Streptococcus pneumoniae-associated hemolytic uremic syndrome and hemolytic anemia.

    Science.gov (United States)

    Burin des Roziers, Nicolas; Chadebech, Philippe; Bodivit, Gwellaouen; Guinchard, Emmanuelle; Bruneel, Arnaud; Dupré, Thierry; Chevret, Laurent; Jugie, Myriam; Gallon, Philippe; Bierling, Philippe; Noizat-Pirenne, France

    2015-06-01

    Pneumococcal hemolytic uremic syndrome (P-HUS) is a rare but severe complication of invasive pneumococcal disease (IPD) in young children. Consensual biologic diagnosis criteria are currently lacking. A prospective study was conducted on 10 children with culture-confirmed IPD. Five presented with full-blown P-HUS, three had an incomplete form with hemolytic anemia and mild or no uremia (P-HA), and two had neither HUS nor HA. Thomsen-Friedenreich (T), Th, and Tk cryptantigens and sialic acid expression were determined on red blood cells (RBCs) with peanut (PNA), Glycine soja (SBA), Bandeiraea simplicifolia II, and Maackia amurensis lectins. Plasma concentrations of the major endogenous T-antigen-binding protein, galectin-3 (Gal-3), were analyzed. We found that RBCs strongly reacted with PNA and SBA lectins in all P-HUS and P-HA patients. Three P-HUS and three P-HA patients showed also concomitant Tk activation. Direct antiglobulin test (DAT) was positive in three P-HUS (one with anti-C3d and two with anti-IgG) and two P-HA patients (one with anti-C3d and one with anti-IgG). RBCs derived from the two uncomplicated IPD patients reacted with PNA but not with SBA lectin. Gal-3 plasma concentrations were increased in all P-HUS patients. The results indicate high levels of neuraminidase activity and desialylation in both P-HUS and P-HA patients. T-antigen activation is more sensitive than DAT for P-HUS diagnosis. Combining PNA and SBA lectins is needed to improve the specificity of T-antigen activation. High concentrations of Gal-3 in P-HUS patients suggest that Gal-3 may contribute to the pathogenesis of P-HUS. © 2014 AABB.

  14. Thomsen-Friedenreich (T) antigen as marker of myoepithelial and basal cells in the parotid gland, pleomorphic adenomas and adenoid cystic carcinomas. An immunohistological comparison between T and sialosyl-T antigens, alpha-smooth muscle actin and cytokeratin 14

    DEFF Research Database (Denmark)

    Therkildsen, M H; Mandel, U; Christensen, M

    1995-01-01

    was the only marker of cells in solid undifferentiated areas of adenoid cystic carcinomas. Our study supports the view, that modified "myoepithelial" cells in the tumours consist of a mixture of basal cells and myoepithelial cells. None of the investigated structures was in itself an ideal marker......Controversy centres on the role and identification of myoepithelial (MEC) and basal cells in salivary gland tumours, and recent studies suggest that both basal cells and myoepithelial cells participate in the formation of salivary gland tumours. We have correlated the expression of different well......-known markers of normal MEC/basal cells (i.e. alpha-smooth muscle actin and cytokeratin 14) with T (Thomsen-Friedenreich) antigen and its sialylated derivative: sialosyl-T antigen,) in 17 normal parotid glands and in two tumour types with MEC participation (i.e pleomorphic adenomas (PA) and adenoid cystic...

  15. Kodanikud ja valdkonnad : Veneetsia biennaal, näiteks / Elin Kard

    Index Scriptorium Estoniae

    Kard, Elin

    2007-01-01

    52. kaasaegse kunsti biennaal Veneetsias 10.06.-21.11.2007. Põhinäitusest "Think With The Senses - Feel With The Mind. Art In The Present Tense", kuraator Robert Storr. Ülevaade rahvuspaviljonidest Giardinis. Eestit esindab Marko Mäetamm isikunäitusega "Losers' Paradise", kuraator Mika Hannula

  16. Kommenteerimata jäänud geopoliitika, turumajandus ja amneesia Moskvas / Elin Kard

    Index Scriptorium Estoniae

    Kard, Elin

    2007-01-01

    Moskva 2. kaasaegse kunsti biennaalist. Oma töid eksponeerivad üle saja kunstniku 35 maalt. Pikemalt Jossif Bakshteini kuraatoriprojektist "Ainult kommentaarid? Kunst darvinistliku ühiskonna ajastul", Iara Boubnova kuraatoriprojektist "Ajalugu olevikus" ja Rosa Martinezi ning Fulva Edemci projektist "Pärast kõike"

  17. Studies on the specificity of immunological reactions of synthetic and natural Thomsen-Friedenreich antigens

    International Nuclear Information System (INIS)

    Hoeppner, W.

    1982-01-01

    A number of derivatives of disaccharide β-D-Gal-(1,3)-D-GalNAc, the carbohydrate component of T-antigen, and four different synthetic antigens having this disaccharide structure have been investigated. The immunological reactions with native human antibodies and rabbit immune antibodies have been studied in the haemagglutination inhibition test and in RIA. The findings are relevant to the use of synthetic carbohydrate antigens as model substances for immunological studies. (orig./MG) [de

  18. Aglutinina anti-T (Thomsen-Friedenreich na doença de Chagas

    Directory of Open Access Journals (Sweden)

    Marcos Palatnik

    1986-10-01

    Full Text Available Uma amostra de soros de pacientes e controles de uma área endêmica da Doença de Chagas do País foi titulada contra hemácias de grupo O tratadas pela neuraminidase (células OT ativadas e hemacias normais de grupo A e B (sistema ABO. Também foram feitos alguns testes de aglutinação de hemácias de pacientes com cardiomiopatia com as lectinas de amendoim (anti-T + anti-Tk e com anticorpo humano anti-T. O escore médio da aglutinina anti-T dos pacientes foi similar ao do grupo controle. En- tretanto, o escore médio dos indivíduos com a forma cardíaca íoi significantemente maior que o dos pacientes assintomáticos e também maior que o do grupo controle. A comparação entre indivíduos com sorologia diagnóstica positiva versus negativa foi não significante. Nem a sorologia para Chagas nem as variáveis raça, sexo, idade, idade ao quadrado, in-fecção intestinal parasitária, teor de proteínas do soro, volume globular eritrocitário (hema-tócrito, grau de palidez da mucosa bucal, cardíomiopatia e os termos de interação sexo x idade, sexo x idade ao quadrado, estão associados significativamente com o logaritmo do título ou com o logaritmo do escore de aglutinação. Os escores de aglutinação das aglutininas anti-A e anti-B do sistema de grupo sangüíneo ABO estão dentro da faixa de variação normal. As hemácias de pacientes com a forma cardíaca não são aglutinadas nem pelas lectinas de amendoim (antiT + anti-Tk e da soja (anti-T nem pela aglutinina anti-T de origem humana. A prova de Coombs direta foi negativa em todos os pacientes, demonstrando a aparente ausência de imunoglobulinas IgG e IgM na superfície eritrocitária. O fato de que o aumento dos níveis de anti-T só foi detectado em uma das formas clínicas da doença em pacientes da mesma área endêmica constitui um argumento contra a possibilidade de que a variação observada seja produzida por uma infecção concomitante.

  19. Hobusepea ja Rael Arteli galerii osalesid möödunud nädalavahetusel... / Elin Kard ; interv. Reet Varblane

    Index Scriptorium Estoniae

    Kard, Elin

    2008-01-01

    Galeriid osalesid Berliini Kunstiakadeemias IGBK (Internationale Gesellschaft der Bildenden Künste ehk Visuaalkunsti Rahvusvahelise Ühingu) korraldatud non-profit projektis "Art Swap Europe/Euroopa kunstivahetus". Projekti eesmärgist, mida see andis Hobusepea galeriile ja annab kunstnikele

  20. Sotsiaaltöö eriala üliõpilaste tagasivaade vaimse koolikiusamise kogemusele / Elin Kütt ; juhendaja Pille Kriisa

    Index Scriptorium Estoniae

    Kütt, Elin

    2013-01-01

    Kokkuvõte Lääne-Viru Rakenduskõrgkooli sotsiaaltöö eriala üliõpilase lõputööst, mille eesmärgiks oli uurida üliõpilaste koolikiusamise kogemusi ja kogemuse mõju praegusele elule ning seoseid kiusamiskogemuse ja sotsiaaltöö eriala valiku vahel

  1. Antonio Gramsci’de Entelektüelin Bir Eleştirisi Olarak Praksis Düşüncesi

    OpenAIRE

    AKKAYA, Aysun YARALI

    2014-01-01

    This study critically focuses on Antonio Gramsci's approach to the intellectuality, which explains the latter term through class. Thus, the term praxis which plays a fundamental role in Gramsci's critique of the definition of the intellectual is discussed. Gramsci criticize the perception of intellectual solely and simply as a person distinct and above from society. According to Gramsci, intellectual is not only a person of reflection but also a person of practice. Hence, Gramsci re...

  2. Tööõnnetuse või kutsehaiguse tõttu tekitatud kahju hüvitamise õiguslik reguleerimine : [bakalaureusetöö] / Elin Kangor ; Tartu Ülikool, õigusteaduskond ; juhendaja: Gaabriel Tavits

    Index Scriptorium Estoniae

    Kangor, Elin

    2000-01-01

    Tööõnnetuskindlustuse regulatsioon Eesti Vabariigis 1918-40, tööõnnetuste ja kutsehaiguste kehtiv seadusandlus, kontseptsioon, kohtupraktika kahju hüvitamise kohta, rahvusvahelised standardid (ILO, Euroopa Sotsiaalkindlustuskoodeks)

  3. Thomsen-Friedenreich (T) antigen as marker of myoepithelial and basal cells in the parotid gland, pleomorphic adenomas and adenoid cystic carcinomas. An immunohistological comparison between T and sialosyl-T antigens, alpha-smooth muscle actin and cytokeratin 14

    DEFF Research Database (Denmark)

    Therkildsen, M H; Mandel, U; Christensen, M

    1995-01-01

    Controversy centres on the role and identification of myoepithelial (MEC) and basal cells in salivary gland tumours, and recent studies suggest that both basal cells and myoepithelial cells participate in the formation of salivary gland tumours. We have correlated the expression of different well...

  4. Acquisition Quality Improvement Within Naval Facilities Engineering Command Southwest

    Science.gov (United States)

    2015-06-01

    support, encouragement, prayers, and the endless cups of coffee you surprised me with. I treasure you and have a lifetime to show you my gratitude. To...fund two of the three ELINS. A mod to delete the third ELIN was never performed. 43 (7) Some modifications referenced the incorrect authority. (8

  5. Riigivõimu ülesannete üleandmine eraõiguslikele isikutele vabakutseliste kohtutäiturite näitel : [bakalaureusetöö] / Elin Palts ; Tartu Ülikooli Õigusinstituut ; juhendajad: Jaanus Ots, Kaire Pikamäe

    Index Scriptorium Estoniae

    Palts, Elin

    2003-01-01

    Avaliku halduse reformi mõiste, avalike ülesannete eraõiguslikele isikutele üleandmise erinevad mudelid, täitevsüsteemi reform, avalik-õiguslike nõuete jaotamine kohtutäiturite vahel, lisateenuste osutamine kohtutäiturite poolt

  6. Raamat : [Tutvustus] / Livia Viitol

    Index Scriptorium Estoniae

    Viitol, Livia, 1953-

    1996-01-01

    Toona, Elin. Lotukata; Sagan Franȯise. Kurbus kummaline tunne. Killuke päikest jahedas vees; Vee, Elo. Võlavalgel; Plath Sylvia. Klaaskuppel; Pühakuteraamat : Nende elulood, teod ja ikonograafilised embleemid; Terhart, Franjo. Mina, Grace O'Malley

  7. Birma sõjavägi jätkab protestide mahasurumist toore jõuga / Karin Dean

    Index Scriptorium Estoniae

    Dean, Karin

    2007-01-01

    Sõjaväe ja meeleavaldajate kokkupõrgetest Birmas, armee rünnakutest kloostritele ja protestijatele, mille tulemusel on hukkunuid. ÜRO ja EL-i hukkamõistvast suhtumisest. Lisa: Sõjaväeline Birma

  8. Vælgeranalyse: NA får det svært med skat

    DEFF Research Database (Denmark)

    Thomsen, Søren Risbjerg

    2007-01-01

    ANALYSE: NAs skatteprogram - bl.a. om fjernelse af topskatten - afvises bredt af vælgerne, skriver professor Søren Risbjerg Thomsen. Udgivelsesdato: 28. maj 2007......ANALYSE: NAs skatteprogram - bl.a. om fjernelse af topskatten - afvises bredt af vælgerne, skriver professor Søren Risbjerg Thomsen. Udgivelsesdato: 28. maj 2007...

  9. Topics of Evolutionary Computation 2001

    DEFF Research Database (Denmark)

    Ursem, Rasmus Kjær

    This booklet contains the student reports from the course: Topics of Evolutionary Computation, Fall 2001, given by Thiemo Krink, Rene Thomsen and Rasmus K. Ursem......This booklet contains the student reports from the course: Topics of Evolutionary Computation, Fall 2001, given by Thiemo Krink, Rene Thomsen and Rasmus K. Ursem...

  10. Skred i marts: S minus seks mandater, SF plus ni

    DEFF Research Database (Denmark)

    Thomsen, Søren Risbjerg

    2008-01-01

    NYHED: "Tilslutningen til S går ad helvede til", skriver professor Søren Risbjerg Thomsen om snittet af meningsmålinger i marts.......NYHED: "Tilslutningen til S går ad helvede til", skriver professor Søren Risbjerg Thomsen om snittet af meningsmålinger i marts....

  11. Majs målinger: Dødt løb mellem blokkene

    DEFF Research Database (Denmark)

    Thomsen, Søren Risbjerg

    2009-01-01

    MÅNEDSSNIT: Maj tegner nogle langsigtede tendenser, som kan få betydning for begge blokke, skriver professor Søren Risbjerg Thomsen.......MÅNEDSSNIT: Maj tegner nogle langsigtede tendenser, som kan få betydning for begge blokke, skriver professor Søren Risbjerg Thomsen....

  12. 76 FR 381 - Notice of Availability of the Draft Environmental Impact Statement/Draft Environmental Impact...

    Science.gov (United States)

    2011-01-04

    [email protected] . Fax: (951) 697-5299. Mail: ATTN: Greg Thomsen, BLM California Desert District Office (CDDO... our mailing list, contact Greg Thomsen, telephone: (951) 697-5237; address: BLM California Desert... quality, biological resources, cultural resources, water resources, geological resources and hazards, land...

  13. Danskernes racisme

    DEFF Research Database (Denmark)

    Necef, Mehmet Ümit

    2010-01-01

    Jens Peter Frølund Thomsen, politolog fra Århus Universitet, har i bogen Konflikten om de nye danskere (2006) undersøgt danskernes holdninger til her-boende etniske minoriteter, herunder racismens omfang og dens former. Ar-tiklen diskuterer Thomsens definition på racisme og hans behandling af sin...

  14. Chest wall reconstruction with acellular dermal matrix (Strattice™) and a TRAM flap

    DEFF Research Database (Denmark)

    Brunbjerg, Mette Eline; Juhl, Alexander Andersen; Damsgaard, Tine Engberg

    2014-01-01

    Mette Eline Brunbjerg, Alexander Andersen Juhl, Tine E. Damsgaard. "Chest wall reconstruction with acellular dermal matrix (Strattice™) and a TRAM flap.” Acta Oncol. 2013 Jun;52(5):1052-4. Epub 2012 Oct 24. PMID: 23095144......Mette Eline Brunbjerg, Alexander Andersen Juhl, Tine E. Damsgaard. "Chest wall reconstruction with acellular dermal matrix (Strattice™) and a TRAM flap.” Acta Oncol. 2013 Jun;52(5):1052-4. Epub 2012 Oct 24. PMID: 23095144...

  15. Comment on “Geochemistry of buried river sediments from Ghaggar Plains, NW India: Multi-proxy records of variations in provenance, paleoclimate, and paleovegetation patterns in the late quaternary” by Ajit Singh, Debajyoti Paul, Rajiv Sinha, Kristina J. Thomsen, Sanjeev Gupta

    Science.gov (United States)

    Clift, Peter D.; Giosan, Liviu; East, Amy E.

    2016-01-01

    Singh et al. (2016) published a geochemical record of sediment compositions from the flood plain of the Ghaggar River in western India and use the changing provenance, particularly as traced by Nd isotope composition, to reconstruct how erosion patterns have changed over the past 100 k.y. In doing so they propose a link between climate change and erosion, and they argue for more erosion from the Higher Himalaya during warmer interglacial periods and more from the Lesser Himalaya during glacial intervals. While we support the concept of erosion patterns being climatically modulated we here take the opportunity to compare the data presented by Singh et al. (2016) to relevant published records within the region greater Ghaggar region and to open a balanced discussion on how climate and erosion are coupled in the western Himalaya.

  16. Comment on "A statistical comparison of solar wind sources of moderate and intense geomagnetic storms at solar minimum and maximum" by Zhang, J.-C., M. W. Liemohn, J. U. Kozyra, M. F. Thomsen, H. A. Elliott, and J. M. Weygand, JGR, 2006

    OpenAIRE

    Yermolaev, Yu. I.; Yermolaev, M. Yu.; Lodkina, I. G.

    2006-01-01

    Conditions in the solar wind resulting in magnetic storms on the Earth are a subject of long and intensive investigations. Recently Zhang et al. (2006), published a paper, where they used superposed epoch analyses method to study solar wind features during 549 geomagnetic storms. Unfortunately, the used methodical approach has not allowed to improve essentially understanding of relation of magnetic storms with conditions in the solar wind, and first of all for the following reasons: (1) they ...

  17. The Language of Objects

    DEFF Research Database (Denmark)

    Eskildsen, Kasper Risbjerg

    2012-01-01

    The Danish amateur scholar Christian Jürgensen Thomsen has often been described as a founder of modern “scientific” archaeology. Thomsen's innovation, this essay argues, reflects developments within neighboring fields, such as philology and history. He reacted against historians who limited...... themselves to histories of texts and therefore abandoned the earliest human history. Instead, he proposed a new history of objects, which included the entire history of humankind. Thomsen's work as director of the Royal Museum of Nordic Antiquities in Copenhagen was especially important for this renewal...

  18. Genetics Home Reference: myotonia congenita

    Science.gov (United States)

    ... stiffness, a phenomenon known as the warm-up effect. The two major types of myotonia congenita are known as Thomsen disease and Becker disease. These conditions are distinguished by the severity ...

  19. NA årsag til mere usikre meningsmålinger

    DEFF Research Database (Denmark)

    Thomsen, Søren Risbjerg

    2007-01-01

    ANALYSE: Det er nørdet men sandt: Meningsmålingerne er mere usikre end længe set, skriver professor Søren Risbjerg Thomsen. Årsag: NA. Udgivelsesdato: 11. september......ANALYSE: Det er nørdet men sandt: Meningsmålingerne er mere usikre end længe set, skriver professor Søren Risbjerg Thomsen. Årsag: NA. Udgivelsesdato: 11. september...

  20. Career guidance for Social Justice in Neo-Liberal Times

    DEFF Research Database (Denmark)

    Thomsen, Rie; Skovhus, Randi Boelskifte; Sultana, Ronald

    SIMPOSIO 16. Career guidance for Social Justice in Neo-Liberal Times (English) Ronald Sultana (Coord.), Tristram Hooley (Coord.), Rie Thomsen, Peter Plant, Roger Kjærgård, Marcelo Afonso Ribeiro, Randi Boelskifte Skovhus and Tron Inglar......SIMPOSIO 16. Career guidance for Social Justice in Neo-Liberal Times (English) Ronald Sultana (Coord.), Tristram Hooley (Coord.), Rie Thomsen, Peter Plant, Roger Kjærgård, Marcelo Afonso Ribeiro, Randi Boelskifte Skovhus and Tron Inglar...

  1. Therapeutic Inhibition of Pro-Inflammatory Signaling and Toxicity to Staphylococcal Enterotoxin B by a Synthetic Dimeric BB-Loop Mimetic of MyD88

    Science.gov (United States)

    2012-07-27

    data not shown). Cell viability ( metabolically active cells) was examined by measuring ATP content using a chemiluminescence method as described...Volume 7 | Issue 7 | e40773 8. Danner R L, Elin RJ, Hosseini JM, Wesley RA, Reilly JM, et al. (1991) Endotoxemia in human septic shock. Chest 99: 169

  2. Tiitelleht olgu asjalik / Oskar Kruus

    Index Scriptorium Estoniae

    Kruus, Oskar, 1929-2007

    2001-01-01

    Arvustus: Veskimägi, Kaljo-Olev. Kahte kappi on ühhetassa maja tarvis... : Eesti raamatukogude ajalugu. Tallinn : K.-O. Veskimägi, 2000 ; Toona, Elin. Rõõm teeb taeva taga tuld : Ernst Enno. Tartu : Ilmamaa, 2000

  3. On the use of visual methodologies in educational policy research

    African Journals Online (AJOL)

    of Charles Dickens' Oliver Twist, a social representation of the other in Vic- torian England. In fact, as Wehbi, Elin & El-Lahib (2010) argue, despite the international pro- motion of the rights-based agenda, the affected groups being supported by international development discourse tend to be absent or represented with ...

  4. Ilmus kogumik eesti naiste elulugusid inglise keeles

    Index Scriptorium Estoniae

    2006-01-01

    Carrying Linda's stones : an anthology of Estonian women's life stories / editors: Suzanne Stiver Lie, Lynda Malik, Ilvi Jõe-Cannon, Rutt Hinrikus ; foreword by H.E. Aldona Wos. Tallinn : Tallinn University Press, 2006. Sisaldab Elin Toona jt. elulugusid. Vt. ka SL Õhtuleht, 30. sept., lk. 27

  5. 9. VII avati Hobusepea galeriis...

    Index Scriptorium Estoniae

    2003-01-01

    Elin Kardi kureeritud näitus "Chart" - üks 2003. a. Eesti Maalikunstnike Liidu aastanäituse sarja projektidest. Väljas olevad tööd vahetuvad kord nädalas vastavalt saavutatud kohtadele publiku koostatavas "maalikunsti edetabelis"

  6. Vegetables, Coctails & Reflections / Marco Laimre

    Index Scriptorium Estoniae

    Laimre, Marko, 1968-

    2006-01-01

    Pealkirja "Vegetables, Coctails & Reflections" kandis Tallinna Kunstihoones 8.04.-28.05.2006 avatud Elin Kardi, Marko Mäetamme, Marco Laimre ja Andres Tali ühisnäitusel "Vägivald ja propaganda" Marco Laimre installatsioon. Marco Laimre esinemine raadiosaates "kunst.er" Klassikaraadios 16.04.2006

  7. Hetkebuklett kunstist Pärnus / Tiiu Leis

    Index Scriptorium Estoniae

    Leis, Tiiu

    1998-01-01

    Nelja maalikunstniku ئ Kostabi, Navitrolla, Van der Blut, Kaljo Simson ئ näitusest Caplini keskuses; Jelgava kunstnike (Lolita Zikmane, Kalvis Zuters, Edvin Kalnieks, Ieva Vitola) näitusest Linnagaleriis; näitus "Musik in der Kunzt" teatri palmisaalis, kus Urmas Uustal (1963), Elin Kard, Kristiina Väljamäe interpreteerivad muusikat installatsioonide, maalide ja söejooniste kaudu

  8. "ArtGenda" erobert Hamburg / Anders Härm

    Index Scriptorium Estoniae

    Härm, Anders, 1977-

    2002-01-01

    7.-23. VI Hamburgis Läänemere-äärsete linnade noorte kunstnike biennaal "ArtGenda". Eestist osalevad projektides rühmitus Valie Export Society (Killu Sukmit, Mari Laanemets, Kadi Estland), rühmitus Tiit Sokk (Ulvi Tiit, Marili Sokk), ESTO TV (Ken & Tolk, Andres Maimik), Elin Kard, Aivar Tõnso, Kiwa

  9. Review of Never Alone [game

    Directory of Open Access Journals (Sweden)

    Andrew Reinhard

    2015-01-01

    Full Text Available Review of Never Alone (Kisima Ingitchuna, an atmospheric platformer and puzzle game (built on the Unity engine released in late 2014 by Upper One Games and education company E-Line Media. It invites one or two players to explore a central story from the Iñupiat, Native Alaskans, with the rewards of additional storytelling by elders and community members.

  10. Nitrogen cycling in the soil-plant system along a precipitation gradient in the Kalahari sands

    CSIR Research Space (South Africa)

    Aranibar, JN

    2004-03-01

    Full Text Available cyclone Eline (Otter et al., 2002). The mean annual precipitation for all sites was estimated from long-term precipitation records (Swap et al., 2003; Griffiths, 1972; Bekker & De Wit, 1991; and data from the Botswana Meteoro- logical Department...

  11. Andres Tali sõnavõtt ettekannete päeval = Andres Tali's speech given on the lecture day / Andres Tali

    Index Scriptorium Estoniae

    Tali, Andres, 1956-

    2006-01-01

    Kaasaegse Kunsti Eesti Keskuse ettekannete päev "Kunstnike moraalsed valikud kultuurikonfliktides" 27.04.2006 Tallinna Kunstihoones. Oma installatsioonist "Pastoraalne pastishsh" ning videost "Vägivald ja propaganda - The Movie" samas 8.04.-28.05.2006 avatud Elin Kardi, Marko Mäetamme, Marco Laimre ja Andres Tali ühisnäitusel "Vägivald ja propaganda"

  12. EKL aastanäitus

    Index Scriptorium Estoniae

    2005-01-01

    "Tehnobia" Tallinna Kunstihoones 26. V-16. VII 2006. Kuraator Leonhard Lapin. Ideekavandid esitada Eesti Kunstnike Liidu büroosse 27. I 2006. "Kurja lilled/Flowers of evil" Hobusepea ja Draakoni galeriis 16. VIII-4. IX 2006. Projekti kuraator Elin Kard

  13. Data of evolutionary structure change: 1DDJB-2FODA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1DDJB-2FODA 1DDJ 2FOD B A SFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTR-...in>A 2FODA SLQYRSGSSWAHT E...line> 2FOD A 2FODA...A 347 ARG CA 265 2FOD A 2FODA... A 2FODA HCVDR---ELTFR

  14. Marko Mäetamme tekst ülekuulamiselt = Marko Mäetamm's confession, made during an interrogation / Marko Mäetamm

    Index Scriptorium Estoniae

    Mäetamm, Marko, 1965-

    2006-01-01

    Marko Mäetamme esinemine raadiosaates "kunst.er" Klassikaraadios 16.04.2006. Oma töödest Tallinna Kunstihoones 8.04.-28.05.2006 avatud Elin Kardi, Marko Mäetamme, Marco Laimre ja Andres Tali ühisnäitusel "Vägivald ja propaganda", Emergency Biennale'ist, osalemisest sellel

  15. Use of the FAO AquaCrop model in developing sowing guidelines ...

    African Journals Online (AJOL)

    2014-03-03

    Mar 3, 2014 ... sowing guidelines for rainfed maize in Zimbabwe. Teddious Mhizha1*, Sam Geerts2, Eline ... from intensification of production in rainfed farming sys- tems. Rockström et al. (2003) showed that it is ...... case, the degree of shading indicates the order of preference for sowing periods. For late sowing, short ...

  16. Mäss põhjusega : kortermaja Silodamil Amsterdamis / Klaske Havik

    Index Scriptorium Estoniae

    Havik, Klaske, 1975-

    2002-01-01

    Büroo MVRDV suurim elamuprojekt. Arhitektid Winy Maas, Jacob van Rijs, Nathalie de Vries, kaasa töötasid Frans de Witte, Willem Timmer, Eline Strijkers, Bernd Felsinger, Duzan Koepel. Viis võistlustöö kaasautorit. Hoone paikneb kai tipus, on ehitatud vette postide peale. Ill.: 7 plaani, 11 vaadet

  17. An acoustic eikonal equation for attenuating VTI media

    KAUST Repository

    Hao, Qi

    2016-09-06

    We present an acoustic eikonal equation governing the complex-valued travel time of P-waves in attenuating, transversely isotropic media with a vertical symmetry axis (VTI). This equation is based on the assumption that the Pwave complex-valued travel time is independent of the Swave velocity parameter v in Thomsen\\'s notation and the attenuation coefficient A in the Thomsen-type notation for attenuating VTI media. We combine perturbation theory and Shanks transform to develop practical approximations to the attenuating acoustic eikonal equation, capable of admitting analytical description of the attenuation in homogeneous media. For a horizontal, attenuating VTI layer, we also derive non-hyperbolic approximations for the real and imaginary parts of the complex-valued reflection travel time.

  18. Modeling of carbon dioxide absorption by aqueous ammonia solutions using the Extended UNIQUAC model

    DEFF Research Database (Denmark)

    Darde, Victor Camille Alfred; van Well, Willy J. M.; Stenby, Erling Halfdan

    2010-01-01

    An upgraded version of the Extended UNIQUAC thermodynamic model for the carbon dioxide-ammonia-water system has been developed, based on the original version proposed by Thomsen and Rasmussen. The original model was valid in the temperature range 0-110°C, the pressure range 0-10 MPa and the conce......An upgraded version of the Extended UNIQUAC thermodynamic model for the carbon dioxide-ammonia-water system has been developed, based on the original version proposed by Thomsen and Rasmussen. The original model was valid in the temperature range 0-110°C, the pressure range 0-10 MPa...

  19. Dét, der forsvinder, tager jeg med

    DEFF Research Database (Denmark)

    Auken, Sune; Skriver, Svend

    Bogen rummer en samlet og nuanceret fortolkning af udviklinger, sammenhænge og spændingsforhold fra værk til værk i Søren Ulrik Thomsens poesi og poetik fra City Slang (1981) til Det værste og det bedste (2002).......Bogen rummer en samlet og nuanceret fortolkning af udviklinger, sammenhænge og spændingsforhold fra værk til værk i Søren Ulrik Thomsens poesi og poetik fra City Slang (1981) til Det værste og det bedste (2002)....

  20. Physical modeling and analysis of P-wave attenuation anisotropy in transversely isotropic media

    Digital Repository Service at National Institute of Oceanography (India)

    Zhu, Y.; Tsvankin, I.; Dewangan, P.; Van Wijk, K.

    phase attenuation coefficient A governed by the Thomsen- style attenuation-anisotropy parameters H9280Q and H9254Q. Whereas the symmetry axis of the angle-dependent coefficient Aprac- tically coincides with that of the velocity function, the magni- tude... and Tsvankin H208492004, 2006H20850 introduced Thomsen-style attenuation parameters H9280Q, H9254Q, and H9253Q de- rived from the Q-matrix for transversely isotropic H20849TIH20850 media and used the new notation to obtain simple approximations for the angle...

  1. Paying for sex-only for people with disabilities?

    Science.gov (United States)

    Earp, Brian D; Moen, Ole Martin

    2016-01-01

    Thomsen (2015) argues that people with disabilities should be granted an exception to a general prohibition on paying for sex. In this response, we argue that Thomsen's call for an exception does not withstand careful scrutiny. The concerns that appear to motivate his argument point instead, we argue, to a case for legalization of prostitution, coupled with sensible health and safety regulations. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  2. Strength of the reversible, garbage-free 2 k ±1 multiplier

    DEFF Research Database (Denmark)

    Rotenberg, Eva; Cranch, James; Thomsen, Michael Kirkedal

    2013-01-01

    Recently, a reversible garbage-free 2 k ±1 constant-multiplier circuit was presented by Axelsen and Thomsen. This was the first construction of a garbage-free, reversible circuit for multiplication with non-trivial constants. At the time, the strength, that is, the range of constants obtainable...

  3. 75 FR 29338 - Energy Efficiency of Natural Gas Infrastructure and Operations Conference; Final Notice of Public...

    Science.gov (United States)

    2010-05-25

    ... [email protected] or call toll free 866-208-3372 (voice) or (202)-208-1659 (TTY), or send a FAX to (202... Thomsen, Ormat Technologies. Jeremy Barnes, GE Oil & Gas. 11:45 a.m.--Break for Lunch 12:45 p.m.--Panel 4...

  4. Corporate Ownership by Industrial Foundations

    DEFF Research Database (Denmark)

    Thomsen, Steen

    1999-01-01

    to be relatively inefficient since they lack monitoring by residual claimants and access to equity finance from the stock market. Nevertheless, empirical research (Thomsen 1996) has found that Danish foundation-owned companies do no worse in terms of profitability and growth than companies with dispersed ownership...

  5. A 72-year-old Danish puzzle resolved--comparative analysis of phenotypes in families with different-sized HOXD13 polyalanine expansions

    DEFF Research Database (Denmark)

    Kjær, Klaus Wilbrandt; Hansen, Lars; Eiberg, Hans

    2005-01-01

    to 22 and 24 residues, respectively. Two of these were previously described by Danish pioneers of human genetics, Tage Kemp and Oluf Thomsen. A clinical score was assigned to each limb based on manifestations assumed to represent different degrees of a duplication defect in hand rays 3-4 and foot rays 4...

  6. Reply to: “A response to some unwarranted criticisms of single-grain dating” by J.K. Feathers

    DEFF Research Database (Denmark)

    Thomsen, Kristina Jørkov; Murray, Andrew Sean; Buylaert, Jan-Pieter

    2017-01-01

    In the note “A response to some unwarranted criticisms of single-grain dating” Feathers raises many issues with both the approach and the conclusions of Thomsen et al. (2016). After careful consideration, we find we disagree with Feather's analysis and conclusions, and stand by the original concl...

  7. HOXD13 polyalanine tract expansion in classical synpolydactyly type Vordingborg

    DEFF Research Database (Denmark)

    Kjær, Klaus Wilbrandt; Hedeboe, Jess; Bugge, Merete

    2002-01-01

    of the family described by Thomsen, and detected a 9 triplet polyalanine expansion within HOXD13segregating with the disorder. The phenotypic spectrum in mutation carriers ranged from severe to inapparent bone malformations. In the latter case, only dermatoglyphics revealed the genetic status....

  8. Measuring anhedonia

    DEFF Research Database (Denmark)

    Rømer Thomsen, Kristine

    2015-01-01

    about pleasure, which is often, but not always accessible to conscious awareness." (Rømer Thomsen et al., 2015). This framework is in line with Treadway and Zald's (2011) proposal to differentiate between motivational and consummatory types of anhedonia, and stresses the need to combine traditional self...

  9. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (83rd, Phoenix, Arizona, August 9-12, 2000). Miscellaneous, Part III.

    Science.gov (United States)

    Association for Education in Journalism and Mass Communication.

    The Miscellaneous, part III section of the proceedings contains the following 11 papers: "The Relationship between Health and Fitness Magazine Reading and Eating-Disordered Weight-Loss Methods among High School Girls" (Steven R. Thomsen, Michelle M. Weber, and Lora Beth Brown); "A Practical Exercise for Teaching Ethical Decision…

  10. Data on the quantitative assessment pulmonary ground-glass opacification from coronary computed tomography angiography datasets

    DEFF Research Database (Denmark)

    Kühl, J Tobias; Kristensen, Thomas S; Thomsen, Anna F

    2017-01-01

    We assessed the CT attenuation density of the pulmonary tissue adjacent to the heart in patients with acute non-ST segment elevation myocardial infarction (J.T. Kuhl, T.S. Kristensen, A.F. Thomsen et al., 2016) [1]. This data was related to the level of ground-glass opacification evaluated by a r...

  11. Prediction of mineral scale formation in geothermal and oilfield operations using the Extended UNIQUAC model - Part II. Carbonate-scaling minerals

    DEFF Research Database (Denmark)

    Villafafila, Ada; Thomsen, Kaj; Stenby, Erling Halfdan

    2006-01-01

    Two additional parameters to account for the pressure dependency of solubility are added to the Extended UNIQUAC model presented by Thomsen and Rasmussen (1999). The improved model has been used for correlation and prediction of vapor-liquid-solid equilibrium for different carbonate systems (CaCO...

  12. Comparative effects of undigested and anaerobically digested ...

    African Journals Online (AJOL)

    EJIRO

    Magd et al., 2005). Improvement of environmental con- ditions and public health as well as the need to reduce cost of fertilizing crops are also important reasons for ..... Machin. Assoc. 51(4): 99-104. Thomsen IK (2000). C and N Transformations in 15N Cross-Labeled. Solid Ruminant Manure During Anaerobic Storage., ...

  13. Beretning for undersøgelse af bopladsområde med værkstedsaktivitet fra yngre jernalder/vikingetid, neolitiske anlæg fortrinsvis fra MN A III og en grav fra MN B II. Kalmergården (KU) 2000

    DEFF Research Database (Denmark)

    Bican, Josefine Franck

    2001-01-01

    anlæggelse er omtalt nedenfor i en separat beretning ved Lone Gebauer Thomsen (se bilag 2). Yngre jernalder/vikingetid er den periode, der var bedst repræsenteret på pladsen. Her var spor efter en markeds-/produktionsplads, der er registreret vha. 3735 detektorfund, hvor især sølvskatten (KU 2337) skal...

  14. Obsolescence – understanding the underlying processes

    NARCIS (Netherlands)

    Thomsen, A.F.

    2017-01-01

    Obsolescence, defined as the process of declining performance of buildings, is a serious threat for the value, the usefulness and the life span of built properties. Thomsen and van der Flier (2011) developed a model in which obsolescence is categorised on the basis of two distinctions, i.e. between

  15. Obsolescence : The underlying processes

    NARCIS (Netherlands)

    Thomsen, A.F.; Nieboer, N.E.T.; Van der Flier, C.L.

    2015-01-01

    Obsolescence, defined as the process of declining performance of buildings, is a serious threat for the value, the usefulness and the life span of housing properties. Thomsen and van der Flier (2011) developed a model in which obsolescence is categorised on the basis of two distinctions, namely

  16. Melancholia og endeligheden som vilkår

    DEFF Research Database (Denmark)

    Thomsen, Torsten Bøgh; Bøggild, Jacob

    2016-01-01

    I artiklen præsenterer professor Jacob Bøggild og Ph.d.-studerende Torsten Bøgh Thomsen en læsning af Lars von Triers film, Melancholia, fra 2011. Filmen udfoldes indledningsvist i forhold til Tarkovskijs film "Offeret" med inddragelse af perspektiver fra Maurice Blanchot og Søren Kierkegaard...

  17. 75 FR 49486 - Environmental Impacts Statements; Notice Of Availability

    Science.gov (United States)

    2010-08-13

    ... EIS, USFS, MN, South Fowl Lake Snowmobile Access Project, Proposing a Replacement Snowmobile Trail.... 20100310, Final EIS, BLM, CA, Chevron Energy Solutions Lucerne Valley Solar Project, Proposing To Develop a...: 09/13/2010, Contact: Greg Thomsen, 951-697-5237. EIS No. 20100311, Draft EIS, NRC, FL, Levy Nuclear...

  18. A Career that is Playing to Win

    Science.gov (United States)

    Reese, Susan

    2006-01-01

    As the gaming industry has expanded throughout the United States, job opportunities have grown along with revenue. Holly Thomsen with the American Gaming Association says that, not only has the casino part of the hospitality business grown dramatically, but it encompasses so much--hotels, restaurants, the gaming floor and the shows. He also states…

  19. Sulfuric Acid and Water: Paradoxes of Dilution

    Science.gov (United States)

    Leenson, I. A.

    2004-01-01

    On equilibrium properties of aqueous solutions of sulfuric acid, Julius Thomsen has marked that the heat evolved on diluting liquid sulfuric acid with water is a continuous function of the water used, and excluded absolutely the acceptance of definite hydrates as existing in the solution. Information about thermochemical measurement, a discussion…

  20. Eesti Maalikunstnike Liidu aastanäituste sari

    Index Scriptorium Estoniae

    2003-01-01

    "Nature morte" 2.-30. VI Kohtla-Järve Põlevkivimuuseumis (kuraator Lauri Sillak). "Chart" Tallinna Hobusepea galeriis 9. VII-4. VIII (Elin Kard). "Lõuna-Eesti maastikud" Viljandi Linnagaleriis 7. VIII-12. IX (Jaan Elken). "Hiiu märk" Kärdla kultuurikeskuse galeriis 12. VII-17. VIII (Andres Koort). "Ma olen käinud New Yorgis" Pärnu Linnagaleriis 11. XII 2003-4. I 2004 (Erki Kasemets). Registreerimise tähtajad

  1. Kaitseminister Jürgen Ligi : Eesti lööja saaks valusalt lüüa / Jürgen Ligi

    Index Scriptorium Estoniae

    Ligi, Jürgen, 1959-

    2007-01-01

    Kaitseminister Jürgen Ligi vastab online-intervjuus küsimustele, kuidas tekkis mõte palgaarmeest, kas see ei vähenda rahva kaitsetahet, miks ta peab palgaarmeed otstarbekaks, kas kaitseministril peaks olema sõjaväeline taust, miks ta näeb vajadust minna Eestis üle palgaarmeele, kui pikaks hindab ta Eesti kaitsejõudude iseseisvat vastupanu idanaabri sõjalise löögi korral

  2. Tiina Piisang sai preemia

    Index Scriptorium Estoniae

    2001-01-01

    III rahvusvaheline köitekunstisümpoosion 14.-21. XI Vilniuses. Avati näitus "Raamat". Preemiad: I - Anne Giordani, Prantsusmaa, II - Isabelle Poitras, Kanada, III - Tiina Piisang, ergutuspreemia - Duda Rimantas, Leedu. Eestist osalevad väljapanekul veel Silvi Kalda, Marje Kask, Külli Veelaid, Zhanna Zhuravel, Elin Kard, Piret Männa. Odette Drapeau Kanadast tutvustas kalanaha kasutamisvõimalusi raamatuköitmisel

  3. Iraan Suurbritannia vastu : kes paindus? / Francis Fukuyama

    Index Scriptorium Estoniae

    Fukuyama, Francis

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke 17. apr. lk. 7. Iraani sisepoliitikast seoses 15 Briti mereväejalaväelase arreteerimise ja vabastamisega, Iraani probleemist Islami Revolutsioonilise Kaardiväe (IRGC või Pasradan) ja sellega liidusuhetes olevate institutsioonidega nagu Basj sõjaväeline rühmitus. Autori arvates tahtsid mõned Iraani rühmitused teravdada vastasseisu Suurbritannia ja USA-ga

  4. Short outlines of books by Estonian authors : [annotations] / Rutt Hinrikus, Janika Kronberg

    Index Scriptorium Estoniae

    Hinrikus, Rutt, 1946-

    1998-01-01

    Laretei, Käbi. Eksiil; Toona, Elin. Lotukata; Park, Eeva. Naeru õpilane; Luik, Viivi. Inimese kapike; Laaman, Ilona. Vesi ahjus; Viiding, Juhan (Üdi, Jüri). Kogutud luuletused; Paju, Juhan. Katkenud romaan; Paju, Juhan. Hõõguv rist; Estonian short stories / toim. Kajar Pruul ja Darlene Reddaway; Traat, Mats. Kartaago kiirrong; Kauksi Ülle. Säng; Kross, Jaan. Paigallend; Puhvel, Madli. Symbol of dawn; Kaplinski, Jaan. Võimaluste võimalikkus; Kaplinski, Jaan. Usk on uskmatus

  5. Response of Velocity Anisotropy of Shale Under Isotropic and Anisotropic Stress Fields

    Science.gov (United States)

    Li, Xiaying; Lei, Xinglin; Li, Qi

    2018-03-01

    We investigated the responses of P-wave velocity and associated anisotropy in terms of Thomsen's parameters to isotropic and anisotropic stress fields on Longmaxi shales cored along different directions. An array of piezoelectric ceramic transducers allows us to measure P-wave velocities along numerous different propagation directions. Anisotropic parameters, including the P-wave velocity α along a symmetry axis, Thomsen's parameters ɛ and δ, and the orientation of the symmetry axis, could then be extracted by fitting Thomsen's weak anisotropy model to the experimental data. The results indicate that Longmaxi shale displays weakly intrinsic velocity anisotropy with Thomsen's parameters ɛ and δ being approximately 0.05 and 0.15, respectively. The isotropic stress field has only a slight effect on velocity and associated anisotropy in terms of Thomsen's parameters. In contrast, both the magnitude and orientation of the anisotropic stress field with respect to the shale fabric are important in controlling the evolution of velocity and associated anisotropy in a changing stress field. For shale with bedding-parallel loading, velocity anisotropy is enhanced because velocities with smaller angles relative to the maximum stress increase significantly during the entire loading process, whereas those with larger angles increase slightly before the yield stress and afterwards decrease with the increasing differential stress. For shale with bedding-normal loading, anisotropy reversal is observed, and the anisotropy is progressively modified by the applied differential stress. Before reaching the yield stress, velocities with smaller angles relative to the maximum stress increase more significantly and even exceed the level of those with larger angles. After reaching the yield stress, velocities with larger angles decrease more significantly. Microstructural features such as the closure and generation of microcracks can explain the modification of the velocity anisotropy

  6. Stressede børn

    DEFF Research Database (Denmark)

    Tonseberg, Signe; Thomsen, Pernille

    2016-01-01

    Stressede børn får det bedre, når deres krop får lov at tale. Fysioterapeut Pernille Thomsen lærer børn at bruge kroppen, så de trives bedre. Og der er ingen hokuspokus, for det hele bygger på naturvidenskabelig forskning i kroppens hormoner og stress.......Stressede børn får det bedre, når deres krop får lov at tale. Fysioterapeut Pernille Thomsen lærer børn at bruge kroppen, så de trives bedre. Og der er ingen hokuspokus, for det hele bygger på naturvidenskabelig forskning i kroppens hormoner og stress....

  7. A linearized dispersion relation for orthorhombic pseudo-acoustic modeling

    KAUST Repository

    Song, Xiaolei

    2012-11-04

    Wavefield extrapolation in acoustic orthorhombic anisotropic media suffers from wave-mode coupling and stability limitations in the parameter range. We introduce a linearized form of the dispersion relation for acoustic orthorhombic media to model acoustic wavefields. We apply the lowrank approximation approach to handle the corresponding space-wavenumber mixed-domain operator. Numerical experiments show that the proposed wavefield extrapolator is accurate and practically free of dispersions. Further, there is no coupling of qSv and qP waves, because we use the analytical dispersion relation. No constraints on Thomsen\\'s parameters are required for stability. The linearized expression may provide useful application for parameter estimation in orthorhombic media.

  8. Flere spillere, mange bolde, ingen mål?

    DEFF Research Database (Denmark)

    Thomsen, Rie

    2006-01-01

    This article, made by Rie Thomsen, PhD student, The Guidance Research Unit, The Danish University of Education, is an analysis of the role of the guidance counsellor in relation to the process of validation. The article seeks answers to the following questions: • Which actors are ‘on the playing ...... field' as regards guidance and competence assessment? • How do they perceive the role of guidance in connection with the assessment of skills and competencies? • Is it possible to categorise these various roles? Read the whole article here.......This article, made by Rie Thomsen, PhD student, The Guidance Research Unit, The Danish University of Education, is an analysis of the role of the guidance counsellor in relation to the process of validation. The article seeks answers to the following questions: • Which actors are ‘on the playing...

  9. Det levende, det, der er her nu - Panelsamtale om Antropocæn

    DEFF Research Database (Denmark)

    Thomsen, Torsten Bøgh

    2015-01-01

    Samtale om klimakrise, økologi og det antropocæne mellem professor i geologi og leder af Geologisk Museum, Minik Rosing, bioetiker og medlem af etisk råd Mickey Gjerris og PhD-stipendiat og forsker i økologisk kulturkritik ved Syddansk Universitet, Torsten Bøgh Thomsen. Debatten blev oprindeligt ...... afholdt på Open Air Academy som en del af Dagbladet Informations serie af debatarrangementer. Efterfølgende transkriberet til tidsskriftet Ny Jord af debattens moderator, Jeppe Carstensen.......Samtale om klimakrise, økologi og det antropocæne mellem professor i geologi og leder af Geologisk Museum, Minik Rosing, bioetiker og medlem af etisk råd Mickey Gjerris og PhD-stipendiat og forsker i økologisk kulturkritik ved Syddansk Universitet, Torsten Bøgh Thomsen. Debatten blev oprindeligt...

  10. Commentary on: "Comprehensive transcriptional analysis of early-stage urothelial carcinoma." Hedegaard J, Lamy P, Nordentoft I, Algaba F, Høyer S, Ulhøi BP, Vang S, Reinert T, Hermann GG, Mogensen K, Thomsen MB, Nielsen MM, Marquez M, Segersten U, Aine M, Höglund M, Birkenkamp-Demtröder K, Fristrup N, Borre M, Hartmann A, Stöhr R, Wach S, Keck B, Seitz AK, Nawroth R, Maurer T, Tulic C, Simic T, Junker K, Horstmann M, Harving N, Petersen AC, Calle ML, Steyerberg EW, Beukers W, van Kessel KE, Jensen JB, Pedersen JS, Malmström PU, Malats N, Real FX, Zwarthoff EC, Ørntoft TF, Dyrskjøt L. Cancer Cell. 2016 Jul 11;30(1):27-42.

    Science.gov (United States)

    Lee, Byron H

    2017-09-01

    Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas and showed that NMIBC can be subgrouped into 3 major classes with basal- and luminal-like characteristics and different clinical outcomes. Large differences in biological processes such as the cell cycle, epithelial-mesenchymal transition, and differentiation were observed. Analysis of transcript variants revealed frequent mutations in genes encoding proteins involved in chromatin organization and cytoskeletal functions. Furthermore, mutations in well-known cancer driver genes (e.g., TP53 and ERBB2) were primarily found in high-risk tumors, together with APOBEC-related mutational signatures. The identification of subclasses in NMIBC may offer better prognostication and treatment selection based on subclass assignment. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Pre Stack Depth Migration (Psdm) Anisotropi Vti (Vertical Tilted Isotropy) Untuk Pencitraan Struktur Bawah Permukaan

    OpenAIRE

    Priambodo, Panji Aziz; Maryanto, Sukir; Nurudin, Hasan

    2013-01-01

    Medium isotropi jarang ditemukan di lapisan bumi sehingga perlu dilakukan pendekatan secara anisotropi untuk menghasilkan pemodelan yang baik. Medium anisotropi dapat menyebabkan efek pada data seismik contohnya efek hockey sticks sehingga perlu ditangani secara anisotropi. Jenis anisotropi yang digunakan adalah VTI (Vertical Transverse Isotropy). Secara teori parameter medium anisotropi disebut dengan parameter Thomsen yang terdiri dari delta (δ) dan epsilon (ε). Dengan melakukan PSDM anisot...

  12. Prediction of Mineral Scale Formation in Geothermal and Oilfield Operations using the Extended UNIQUAC Model. Part I: Sulphate Scaling Minerals

    DEFF Research Database (Denmark)

    Garcia, Ada V.; Thomsen, Kaj; Stenby, Erling Halfdan

    2005-01-01

    Pressure parameters are added to the Extended UNIQUAC model presented by Thomsen and Rasmussen (1999). The improved model has been used for correlation and prediction of solid-liquid equilibrium (SLE) of scaling minerals (CaSO4, CaSO4·2H2O, BaSO4 and SrSO4) at temperatures up to 300°C and pressur...

  13. Marine Search, Rescue and Emergency Preparedness Study.

    Science.gov (United States)

    1975-09-01

    Ramsey , Contra Costa County, Admn. Bldg., Martinez, Ca. 228-3000 (Also coronor office) U/W: Contra Costa County Sheriff’s Underwater Diving Team Above...SAR responsibility at resource - Rangers SAR TEAM: Tyler Co, Sheriff’s Ofc. Texas Parks & Wildlife Game Wardens Woodville, Tx. 75979 Tyler & Jasper Cos... Tyler Co. Hosp , 1100 W. Bluff, Woodville 75979 283-2521 (14 mi.) j TOWN BLUFF DAM COE - Thomas R. Thomsen, Park Ranger, Dam Project Office, Woodville

  14. FORSKER: ALT FOREGÅR LIGE NU

    DEFF Research Database (Denmark)

    Bek-Thomsen, Jakob

    2015-01-01

    I løbet af de sidste årtier har vi endegyldigt taget afsked med industrisamfundets opdeling af tiden i otte timers arbejde, otte timers fritid og otte timers søvn. Og vi er ved at bevæge os ind i en verden, hvor nuet er afgørende. Idehistoriker Jakob Bek-Thomsen sætter tiden i et historisk perspe...

  15. Electronic and vibrational Raman spectroscopy of Nd0.5Sr0.5MnO3 ...

    Indian Academy of Sciences (India)

    77, 715 (1996). [8] G Zhao, K Conder, H Keller and K A Muller, Nature (London) 381, 676 (1996). [9] C H Booth, F Bridges, G H Kwei, J M Lawrence, A L Cornelius and J J Neumeier,. Phys. Rev. Lett. 80, 853 (1998). [10] M N Iliev, M V Abrashev, H-G Lee, V N Popov, Y Y Sun, C Thomsen, R L Meng and C W Chu, Phys. Rev.

  16. Digital Crafting and the Challenge to Material Practices

    DEFF Research Database (Denmark)

    Ramsgaard Thomsen, Mette

    2014-01-01

    Mette Ramsgard Thomsen will examine how architecture is influenced by new digital design—the production tools as well as the digital practices that are informing our societies culturally, socially and technologically. Focusing on the tectonic possibilities of textiles to create lighter and more...... responsive environments, she will discuss her collaborations with partners from the fields of computer graphics, human computer interaction, robotics, artificial intelligence....

  17. Conservation in a cup of water: estimating biodiversity and population abundance from environmental DNA.

    Science.gov (United States)

    Lodge, David M; Turner, Cameron R; Jerde, Christopher L; Barnes, Matthew A; Chadderton, Lindsay; Egan, Scott P; Feder, Jeffrey L; Mahon, Andrew R; Pfrender, Michael E

    2012-06-01

    Three mantras often guide species and ecosystem management: (i) for preventing invasions by harmful species, 'early detection and rapid response'; (ii) for conserving imperilled native species, 'protection of biodiversity hotspots'; and (iii) for assessing biosecurity risk, 'an ounce of prevention equals a pound of cure.' However, these and other management goals are elusive when traditional sampling tools (e.g. netting, traps, electrofishing, visual surveys) have poor detection limits, are too slow or are not feasible. One visionary solution is to use an organism's DNA in the environment (eDNA), rather than the organism itself, as the target of detection. In this issue of Molecular Ecology, Thomsen et al. (2012) provide new evidence demonstrating the feasibility of this approach, showing that eDNA is an accurate indicator of the presence of an impressively diverse set of six aquatic or amphibious taxa including invertebrates, amphibians, a fish and a mammal in a wide range of freshwater habitats. They are also the first to demonstrate that the abundance of eDNA, as measured by qPCR, correlates positively with population abundance estimated with traditional tools. Finally, Thomsen et al. (2012) demonstrate that next-generation sequencing of eDNA can quantify species richness. Overall, Thomsen et al. (2012) provide a revolutionary roadmap for using eDNA for detection of species, estimates of relative abundance and quantification of biodiversity. © 2012 Blackwell Publishing Ltd.

  18. Flow requirements in the Hafnia modifications of the Mapleson circuits during spontaneous respiration.

    Science.gov (United States)

    Christensen, K N; Thomsen, A; Hansen, O; Jørgensen, S

    1978-01-01

    The Mapleson A, B, C and D circuits can be changed into non-polluting circuits by employing continuous gas evacuation directly from the circuit, via an ejector flowmeter (Jørgensen 1974); Mapleson A and C circuits with this modification have been described previously as the Hafnia A and C circuits (Christensen 1976, Thomsen & Jørgensen 1976). If evacuation from a closed reservoir is employed, total removal of the expired and surplus gases from the operating theatre is obtained (Jørgensen & Thomsen 1976). There will be resistance to expiration in all the circuits with a relief valve for the discharge of surplus gas. If surplus gas is continuously removed directly from the anaesthetic circuit, the patient breathes in an air compartment at ambient pressure, as long as the removal rate equals the inflow of fresh gas. The relief valve is only included in the circuit to ensure that high pressures do not develop. As in any other circuit, the relief valve remains open except during controlled ventilation. A dumping valve may also be included as a safeguard against low pressures (Jørgensen & Thomsen 1976). The flow requirements of the Hafnia B and D circuits and the corresponding Mapleson circuits have been studied in conscious, spontaneously breathing subjects, and the results are discussed in relation to the flow requirements of other semi-closed system.

  19. Miks on Savisaar ja proua Bush Birma kallal / Mai Loog

    Index Scriptorium Estoniae

    Loog, Mai, 1960-

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke 29. mai lk. 7. Birma sõjaväeline valitsus otsustas taas pikendada aasta võrra Nobeli rahupreemia laureaadi ja demokraatliku opositsiooni liidri Aung San Suu Kyi 11-aastast koduaresti, mille vastu astusid välja USA senaatorid presidendiproua Laura Bushi juhtimisel kui ka Tallinna linnapea Edgar Savisaar koos Pariisi ja Rooma linnapeadega. Birma hunta plaanitavast konstitutsioonist, kus aatomienergia on pandud riigikaitse ja julgeoleku alla. Venemaa aatomienergia agentuuri Rosatomi lepingust Birma huntaga aatomienergia tootmiseks

  20. Negotiating a new day: parents' contributions to supporting students' school functioning after exposure to trauma

    OpenAIRE

    Grell; Røkholt E; Schultz JH; Langballe Å

    2016-01-01

    Eline Grelland Røkholt,1 Jon-Håkon Schultz,2,3 Åse Langballe2 1Department of Allied Health, Bereavement Support Center, Akershus University Hospital, Lørenskog, 2Norwegian Center for Violence and Traumatic Stress Studies, Oslo, 3Department of Education, University of Tromsø, the Arctic University of Norway, Tromsø, Norway Abstract: Parents are advised to get their children back to school soon after exposure to trauma, so that they may receive social su...

  1. Short Outlines of Books by Estonian Authors / Janika Kronberg, Rutt Hinrikus

    Index Scriptorium Estoniae

    Kronberg, Janika, 1963-

    2009-01-01

    Arvustus: Karusoo, Merle. Kui ruumid on täis : Eesti rahva elulood teatritekstides 1982-2005. Tallinn : Varrak, 2008 ; Aleksejev, Tiit. Palveränd. Tallinn : Varrak, 2008 ; Saat, Mari. Lasnamäe lunastaja. Tallinn : Tuum, 2008 ; Tarand, Mari. Ajapildi sees. Tartu : Ilmamaa, 2008 ; Ojamaa, Liisi. Jõgi asfaldi all. Tallinn : Varrak, 2008 ; Kaalep, Ain. Muusad ja maastikud. Luuletused aastaist 1945-2008. Tallinn : Tänapäev, 2008 ; Toona, Elin. Ella. Tallinn : Kultuurileht, 2008 ; Hellerma, Kärt. Sinine missa. Valik reisikirju. Tallinn : Tuum, 2008 ; Raud, Rein. Vend. Tallinn : Tuum, 2008 ; Kruusa, Kalju. Pilvedgi mindgi liigutavadgi. Tallinn : Koma, 2008

  2. Romansk Forum Nr. 20 - 2005

    OpenAIRE

    2005-01-01

    Boulos, Miriam Stendal og Elin Beate Tobiassen: En guise de présentation. 7-9 Le roman français de l'après-guerre Barstad, Guri Ellen: Imitation méthodique et exercice spirituel dans Les ames fortes de Jean Giono. 13-18 Sjursen, Nina: Faits divers, faits historiques dans l'univers fictionnel d'Albert Camus. 19-28 Ulriksen, Solveig Schult: Céline D'un chateau l'autre. 29-37 Bjørsnøs, Annlaug: Ce que peut faire la forme: jeux narratifs et discursifs dans Les Belles images de Sim...

  3. Claim of Status and Foreign Customs in the Medieval Funerary Record. Apropos of Two Examples of Cantabria

    Directory of Open Access Journals (Sweden)

    Enrique GUTIÉRREZ CUENCA

    2017-07-01

    Full Text Available Description and interpretation of two funerary contexts from 12th-13th Centuries Cantabria: the burials with «golden spurs» in San Martín de Elines and the grave with incense pots in Santa María de la Ascensión of Castro Urdiales. The first case connects with the development of noble cavalry in Castile in 13th Century, whereas in the second one the reasons for the presence of a funerary custom unconnected with the local tradition are analysed.

  4. Betydelsen av taktil massage i omvårdnaden av dementa patienter- En systematisk litteraturstudie

    OpenAIRE

    Wetterström, Marina; Swan, Emelie

    2008-01-01

    Syftet med denna systematiska litteraturstudie var att se vilka effekter taktil massage ger hos personer med demens. Sökning av artiklar har gjorts på databaserna CINAHL, ELIN@Dalarna och PubMed där sökorden dementia, massage, nursing, older people, Therapeutic touch och touch användes i olika kombinationer. Litteraturstudien består av kvantitativa och kvalitativa artiklar. Artiklarna skulle vara vetenskapliga och inte publicerade före 1995, de skulle även svara på syfte och frågeställning. F...

  5. Intro / Johannes Saar

    Index Scriptorium Estoniae

    Saar, Johannes, 1965-

    2006-01-01

    Kolmest projektist Tallinna Kunstihoones: 8.04.-28.05. 2006 avatud Elin Kardi, Marko Mäetamme, Marco Laimre ja Andres Tali Ühisnäitusest "Vägivald ja propaganda", selle raames 26.04.-09.05. avatud Emergency Biennale'ist, rahvusvahelisest rändnäitusest Tšetšeenia toetuseks (Tallinnas ühinesid biennaaliga Jüri Ojaver, Neeme Külm, Marco Laimre, Marko Mäetamm), 27.04. toimunud Kaasaegse Kunsti Eesti Keskuse 4. ettekannete päevast "Kunstnike moraalsed valikud kultuurikonfliktides" sarjast "Lisandusi eesti kunstiloole"

  6. Vägivald ja propaganda

    Index Scriptorium Estoniae

    2006-01-01

    8. IV-28. V Tallinna Kunstihoones Elin Kardi, Marco Laimre, Marko Mäetamme ja Andres Tali näitus "Vägivald ja propaganda". 26. IV-7. V näituse raames emergency biennale, rahvusvaheline rändnäitus Tšetšeenia toetuseks. 27. IV Kaasaegse Kunsti Eesti Keskuse IV ettekannete päev "Kunstniku moraalsed valikud liberaalse demokraatia ja islami kokkupõrgetes". Esinevad Margit Sutrop, Johannes Saar, Marek Järvik, Ene-Liis Semper & Eero Epner ning näitusel "Vägivald ja propaganda" osalevad kunstnikud

  7. Profession Dilemmas in the art educational field

    Directory of Open Access Journals (Sweden)

    Eva Lutnæs

    2015-10-01

    Full Text Available The anthology Kunstner eller lærer? Profesjonsdilemmaer i musikk- og kunst­­pedagogisk utdanning (Artist or teacher? Profession Dilemmas in the music and art educational fields is edited by Elin Angelo and Signe Kalsnes. The reviewer concludes there is a label identity construction through the use of terms, including how you choose to position yourself and how you are categorised by others, which makes the book a very valuable contribution to the discussion of the professional dilemma and professional identity of students, teachers and researchers in the art educational fields.

  8. Short outlines of books by Estonian authors / Rutt Hinrikus, Janika Kronberg

    Index Scriptorium Estoniae

    Hinrikus, Rutt, 1946-

    2000-01-01

    Andres Ehin. Alateadvus on alatasa purjus; Peeter Torop. Kultuurimärgid; Matt Barker. Sarah' jalad; Jaan Isotamm. Mina Johnny B.; Jaan Kaplinski. Silm. Hektor; Jaan Kaplinski. Kevad kahel rannikul ehk tundeline teekond Ameerikasse; Rein Raud. Pisiasjad, mis omavad tähtsust; Kerttu Rakke. Kalevipoeg; Elin Toona. Rõõm teeb taeva taga tuld; Veera Saar. Neid ammuseid aegu; Toomas Vint. Nädalavahetusel. Mängides; Varjatud ilus haigus : valik sajandilõpu eesti luuletajaid / koostanud Kajar Pruul; Viiu Härm. Duubel kaks

  9. A study of asthma severity in adult twins

    DEFF Research Database (Denmark)

    Thomsen, Simon Francis; van der Sluis, Sophie; Kyvik, Kirsten Ohm

    2012-01-01

    Introduction: The tendency to develop asthma runs in families, but whether the severity of asthma symptoms is inherited is not known. Objectives: The aim of this study was to examine whether genetic factors influence the variation in the severity of asthma. Methods: Of a sample of 21 133 adult tw...... of asthma symptoms and objectively measured asthma-related traits, respectively, seem to differ. Please cite this paper as: Thomsen SF, van der Sluis S, Kyvik KO and Backer V. A study of asthma severity in adult twins. Clin Respir J 2011; DOI:10.1111/j.1752-699X.2011.00273.x....

  10. Testing the potential of an elevated temperature IRSL signal from K-feldspar

    DEFF Research Database (Denmark)

    Buylaert, Jan-Pieter; Murray, A.S.; Thomsen, Kristina Jørkov

    2009-01-01

    Thomsen, K.J., Murray, A.S., Jain, M., Bøtter-Jensen, L. [2008. Laboratory fading rates of various luminescence signals from feldspar-rich sediment extracts. Radiat. Meas. 43, 1474–1486] have identified a number of feldspar signals which show significantly less anomalous fading than......; detection in the blue–violet region). It is the latter signal that is of interest in this paper. We test such a post-IR IR dating protocol on K-feldspar extracts from a variety of locations and depositional environments and compare the results with those from the conventional IR at 50 °C protocol. Based...

  11. Difference in allelic expression of the CLCN1 gene and the possible influence on the myotonia congenita phenotype

    DEFF Research Database (Denmark)

    Dunø, Morten; Colding-Jørgensen, Eskild; Grunnet, Morten

    2004-01-01

    to be a consequence of a dominant-negative effect. However, a subset of CLCN1 mutations can cause both recessive and dominant MC. We have identified two recessive and two dominant MC families segregating the common R894X mutation. Real-time quantitative RT-PCR did not reveal any obvious association between the total......Mutations in the CLCN1 gene, encoding a muscle-specific chloride channel, can cause either recessive or dominant myotonia congenita (MC). The recessive form, Becker's myotonia, is believed to be caused by two loss-of-function mutations, whereas the dominant form, Thomsen's myotonia, is assumed...

  12. CITA works

    DEFF Research Database (Denmark)

    Ramsgaard Thomsen, Mette; Tamke, Martin; Ayres, Phil

    2015-01-01

    readers with insights into our design-led practice-based architectural research which queries how computation challenges the way we think, design and build architecture. With essays by Professor Mette Ramsgaard Thomsen (Head of CITA), and Dr. Jane Burry (Head of the Spatial Information Architecture...... Laboratory, RMIT) the work is contextualised within the field of digital architectural design practice. These essays also identify the emerging questions and maturing methods that continue to inform CITA’s research within this territory. CITA works marks the first 10 years of our research effort...... and acknowledges the institutions, practices, companies and individuals that have participated, contributed and collaborated with us along the way....

  13. MICCAI ´06 - Workshop on Biophotonics Imaging for Diagnostics and Treatment, October 6, 2006 proceedings, 9th MICCAI Conference

    DEFF Research Database (Denmark)

    Ersbøll, Bjarne Kjær; Jørgensen, Thomas Martini

    2006-01-01

    of Medical Biophysics, University of Toronto, Canada 41 Biomedical applications of terahertz technology / Vincent Wallace, Teraview, United Kingdom 43 The physical principles of chemical recognition in terahertz spectral imaging / Peter Uhd Jepsen and Stewart J. Clark, COM, DTU, Denmark 51 A bidimensional...... interstitial diffuse optical spectroscopy / Anthony Kim et al., Sunnybrook Research Institute, Dept of Medical Biophysics, Toronto, Canada 83 Optical coherence tomography in dermatology / Jakob Thomsen et al., OPL, Risø National Laboratory, Denmark 93 The intrinsic dimension of multispectral images / Cicero...

  14. Architectural Knitted Surfaces

    DEFF Research Database (Denmark)

    Mossé, Aurélie

    2010-01-01

    WGSN reports from the Architectural Knitted Surfaces workshop recently held at ShenkarCollege of Engineering and Design, Tel Aviv, which offered a cutting-edge insight into interactive knitted surfaces. With the increasing role of smart textiles in architecture, the Architectural Knitted Surfaces...... workshop brought together architects and interior and textile designers to highlight recent developments in intelligent knitting. The five-day workshop was led by architects Ayelet Karmon and Mette Ramsgaard Thomsen, together with Amir Cang and Eyal Sheffer from the Knitting Laboratory, in collaboration...

  15. Denmark: Welfare Society, Social Justice and the Role of Career Guidance

    DEFF Research Database (Denmark)

    Thomsen, Rie

    Denmark: Welfare Society, Social Justice and the Role of Career Guidance Dr. Rie Thomsen, Aarhus University in Copenhagen, Denmark Denmark is a welfare state in Scandinavia and amongst the most equal countries in the world but it has dropped from being the most equal country in the world to number...... 11 in 10 years. This presentation considers what social justice means for educational and vocational guidance in Denmark. It covers the development in the Danish career guidance system for young people and show how the service has become more targeted towards marginalised youth. Finally different...

  16. Noncommutative analysis, operator theory and applications

    CERN Document Server

    Cipriani, Fabio; Colombo, Fabrizio; Guido, Daniele; Sabadini, Irene; Sauvageot, Jean-Luc

    2016-01-01

    This book illustrates several aspects of the current research activity in operator theory, operator algebras and applications in various areas of mathematics and mathematical physics. It is addressed to specialists but also to graduate students in several fields including global analysis, Schur analysis, complex analysis, C*-algebras, noncommutative geometry, operator algebras, operator theory and their applications. Contributors: F. Arici, S. Bernstein, V. Bolotnikov, J. Bourgain, P. Cerejeiras, F. Cipriani, F. Colombo, F. D'Andrea, G. Dell'Antonio, M. Elin, U. Franz, D. Guido, T. Isola, A. Kula, L.E. Labuschagne, G. Landi, W.A. Majewski, I. Sabadini, J.-L. Sauvageot, D. Shoikhet, A. Skalski, H. de Snoo, D. C. Struppa, N. Vieira, D.V. Voiculescu, and H. Woracek.

  17. Short outlines of books by Estonian authors / Brita Melts, Rutt Hinrikus, Maire Iro and Maret Vaher

    Index Scriptorium Estoniae

    2013-01-01

    Arvustus: Pärtna, Maarja. Läved ja tüved. Tallinn : Eesti Keele Sihtasutus, 2013 ; Sauter, Peeter. Ära jäta mind rahule. Tallinn : P. Sauter, 2012 ; Viiding, Elo. Teised. Tallinn : Tuum, 2012 ; Mathura. Kumalasepäev. Lelle : Allikaäärne, 2012 ; Kadastik, Mart. Kevad saabub sügisel. Tallinn : Varrak, 2013 ; Mutt, Mihkel. Kooparahvas läheb ajalukku. Tallinn : Fabian, 2012 ; Hargla, Indrek. Apteeker Melchior ja Pirita kägistaja. Tallinn : Varrak, 2013 ; Raud, Rein. Rekonstruktsioon. Tallinn : Mustvalge Kirjastus, 2012 ; Toona, Elin. Into exile : a life story of war and peace. Woodsville (N.H.) : Lakeshore Press, 2013 ; Berg, Maimu. Moemaja. Tartu : Petrone Print, 2012 ; Kareva, Doris, Rooste, Jürgen. Elutants. Tallinn : Verb, 2013 ; Ehin, Kristiina. Paleontoloogi päevaraamat. Tartu : Petrone Print, 2013 ; Maria Lee. Stereomeetria. Tallinn : Verb, 2012

  18. Microprocessor Control of Low Speed VSTOL Flight.

    Science.gov (United States)

    1979-06-08

    FARAMETERSm REil"! I RED B-Y YOIUR PROGiRAM. ALOIN IT IAL C. ALCU-LAT 1 CI * MAY B:E MADE HERE (IF YOU DEFINE THE REOU’IRED PARAMETER-:). *IN ADDI rICON...UILONI, 4. E84) XLO-N1E’=PLON( 1, 1 )*XLON1+AL:IN(2,, 1 )*XLOIN2-+ALO--NC3, 1 )*XLOIN’.:3+ ALOiN (4, 1 )*XLO--N4 XLOIN 1 E’=XLOIN 1 [’+EBLON ( 1, 1 ) *ULflN...1 +E:LCJN (2, 1 ) *ULiJN2+ELIN (*3-, 1 ) *ILCNS-- XLON2DE=ALON(5, 1 )*XLON~I-ALON(4, 1 )*XLON2+ ALOIN (7, 1 )*XLON:3.+ALO-N(c8, 1 )*XLOiN4 XL0IN2-E’=X

  19. Features of 10-M-long, 50-MM-Twin-aperture LHC dipole magnet prototypes

    International Nuclear Information System (INIS)

    Devred, A.

    1998-03-01

    In 1991, the Laboratoire Europeen pour la Physique des particules (CERN) has launched the fabrication in industry of seven 10-m long, 50-mm-twin-aperture dipole magnet prototypes for the Large Hadron Collider (LHC). Three of these prototypes were built in Italy, in collaboration with the Istituto Nazionale di Fisica Nucleare (INFN, by Ansaldo Energia Spa, two were built in Germany by Noell GmbH, one was built in France by a consortium constituted by Jeumont Industries and GEC Alsthom, and the last one was built by a consortium constituted by Elin in Austria and Holec in the Netherlands. In this paper, we review the design and specific features of the seven LHC dipole magnet prototypes. (author)

  20. Cenozoic structures and the tectonic evolution of the eastern North Sea

    DEFF Research Database (Denmark)

    Clausen, O.R.; Nielsen, S.B.; Egholm, D.L.

    2011-01-01

    Abundant seismic sections and well data from the Cenozoic succession in the eastern North Sea area generally reveal normal faulting, salt tectonics and localized tectonic inversion. However, inferences on the Cenozoic dynamic evolution of the region require thorough analysis of interactions between...... or cover tectonism took place. Our objectives are thus 1) to analyze the interaction between basement and cover structures, and if possible 2) to relate the structures to the regional tectonic evolution. The Zechstein evaporites pinch out onto the Ringkøbing-Fyn High, which in the eastern North Sea...... including decompaction in the Central Graben along the Arne-Elin trend shows that two phases of basement related inversion took place duringthe Paleocene-Eocene and the Oligocene. Halokinetics and differential compaction across the Paleogene inversion structure explain later tectonic signals...

  1. Features of 10-M-long, 50-MM-Twin-aperture LHC dipole magnet prototypes

    Energy Technology Data Exchange (ETDEWEB)

    Devred, A. [CEA Saclay, 91 - Gif-sur-Yvette (France). Dept. d`Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l`Instrumentation Associee]|[CERN, Laboratoire Europeen pour la Physique des Particules, Geneva (Switzerland)

    1998-03-01

    In 1991, the Laboratoire Europeen pour la Physique des particules (CERN) has launched the fabrication in industry of seven 10-m long, 50-mm-twin-aperture dipole magnet prototypes for the Large Hadron Collider (LHC). Three of these prototypes were built in Italy, in collaboration with the Istituto Nazionale di Fisica Nucleare (INFN, by Ansaldo Energia Spa, two were built in Germany by Noell GmbH, one was built in France by a consortium constituted by Jeumont Industries and GEC Alsthom, and the last one was built by a consortium constituted by Elin in Austria and Holec in the Netherlands. In this paper, we review the design and specific features of the seven LHC dipole magnet prototypes. (author) 21 refs.

  2. Säg något intressant! : En kvalitativ studie av marknadskommunikation på Facebook

    OpenAIRE

    Johansson, Elin; Johansson, Hanna; Nilsson, Camilla

    2011-01-01

    ABSTRACT Elin Johansson, Hanna Johansson, Camilla Nilsson Say something interesting! A qualitative study of marketing communication on Facebook                               Pages: 36 With the emergence of social media, new ways has been created for companies to reach out to its audience. From being dependent on journalists to provide information, companies today have the ability to self-publish information in the open media channels. The use of social media should not replace traditional mar...

  3. Global changes in Staphylococcus aureus gene expression during human prosthetic joint infection

    DEFF Research Database (Denmark)

    Xu, Yijuan; Nielsen, Per Halkjær; Nielsen, Jeppe Lund

    2016-01-01

    Global changes in Staphylococcus aureus gene expression during human prosthetic joint infection Xu, Yijuan1; Nielsen, Per H.1; Nielsen, Jeppe L.1; Thomsen, Trine R. 1,2; Nielsen, Kåre L.1 and the PRIS study group 1: Center for Microbial Communities, Department of Biotechnology, Chemistry and Envi......Global changes in Staphylococcus aureus gene expression during human prosthetic joint infection Xu, Yijuan1; Nielsen, Per H.1; Nielsen, Jeppe L.1; Thomsen, Trine R. 1,2; Nielsen, Kåre L.1 and the PRIS study group 1: Center for Microbial Communities, Department of Biotechnology, Chemistry...... and Environmental Engineering, Aalborg University, Denmark 2: Danish Technological Institute, Aarhus, Denmark Aim: ”The aim of this study was to gain insight into the in vivo expression of virulence and metabolic genes of Staphylococcus aureus in a prosthetic joint infection in a human subject” Method: ”Deep RNA...... sequencing (RNA-seq) was used for transcriptome profile of joint fluid obtained from a patient undergoing surgery due to acute S. aureus prosthetic joint infection. The S. aureus gene expression in the infection was compared with exponential culture of a S. aureus isolate obtained from the same sample using...

  4. Extended UNIQUAC model for thermodynamic modeling of CO2 absorption in aqueous alkanolamine solutions

    DEFF Research Database (Denmark)

    Faramarzi, Leila; Kontogeorgis, Georgios; Thomsen, Kaj

    2009-01-01

    The extended UNIQUAC model [K. Thomsen, R Rasmussen, Chem. Eng. Sci. 54 (1999) 1787-1802] was applied to the thermodynamic representation of carbon dioxide absorption in aqueous monoethanolamine (MEA), methyldiethanolamine (MDEA) and varied strength mixtures of the two alkanolamines (MEA-MDEA). F......The extended UNIQUAC model [K. Thomsen, R Rasmussen, Chem. Eng. Sci. 54 (1999) 1787-1802] was applied to the thermodynamic representation of carbon dioxide absorption in aqueous monoethanolamine (MEA), methyldiethanolamine (MDEA) and varied strength mixtures of the two alkanolamines (MEA...... alkanolamine systems (MEA-water and MDEA-water). The two just mentioned types of data cover the full concentration range of alkanolamines from extremely dilute to almost pure. The experimental freezing point depression data down to the temperature of -20 degrees C are used. Experimental excess enthalpy (H......-E) data of the binary MEA-water and MDEA-water systems at 25, 40, 65 and 69 degrees C are used as well. In order to enhance the calculation of the infinite dilution activity coefficients of MEA and MDEA, the pure alkanolamines vapor pressure data in a relevant temperature range (up to almost 230 degrees C...

  5. Disability, sex rights and the scope of sexual exclusion.

    Science.gov (United States)

    Liberman, Alida

    2017-11-03

    In response to three papers about sex and disability published in this journal, I offer a critique of existing arguments and a suggestion about how the debate should be reframed going forward. Jacob M. Appel argues that disabled individuals have a right to sex and should receive a special exemption to the general prohibition of prostitution. Ezio Di Nucci and Frej Klem Thomsen separately argue contra Appel that an appeal to sex rights cannot justify such an exemption. I argue that Appel's argument fails, but not (solely) for the reasons Di Nucci and Thomsen propose, as they have missed the most pressing objection to Appel's argument: Appel falsely presumes that we never have good reasons to restrict someone's sexual liberty rights. More importantly, there is a major flaw in the way that all three authors frame their positive accounts. They focus on disability as a proxy for sexual exclusion, when these categories should be pulled apart: some are sexually excluded who are not disabled, while some who are disabled are not sexually excluded. I conclude that it would be less socially harmful and more productive to focus directly on sexual exclusion per se rather than on disability as a proxy for sexual exclusion. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  6. Binding of galectin-1 to breast cancer cells MCF7 induces apoptosis and inhibition of proliferation in vitro in a 2D- and 3D- cell culture model.

    Science.gov (United States)

    Geiger, Pamina; Mayer, Barbara; Wiest, Irmi; Schulze, Sandra; Jeschke, Udo; Weissenbacher, Tobias

    2016-11-08

    Galectin-1 (gal-1) belongs to the family of β-galactoside-binding proteins which primarily recognizes the Galβ1-4GlcNAc sequences of oligosaccharides associated with several cell surface glycoconjugates. The lectin recognizes correspondent glycoepitopes on human breast cancer cells. Galectin-1 is expressed both in normal and malignant tissues. Lymphatic organs naturally possessing high rates of apoptotic cells, express high levels of Galectin-1. Furthermore galectin-1 can initiate T cell apoptosis. Binding of galectin-1 to trophoblast tumor cells presenting the oncofetal Thomsen-Friedenreich (TF) carbohydrate antigen inhibits tumor cell proliferation. In this study we examined the impact galectin-1 has in vitro on cell proliferation, apoptotic potential and metabolic activity of MCF-7 and T-47D breast cancer cells in dependence to their expression of the Thomsen-Friedenreich (TF) tumor antigen. For proliferation and apoptosis assays cells were grown in presence of 10, 30 and 60 μg gal-1/ml medium. Cell proliferation was determined by a BrdU uptake ELISA. Detection of apoptotic cells was done by M30 cyto death staining, in situ nick translation and by a nucleosome ELISA method. Furthermore we studied the impact galectin-1 has on the metabolic activity of MCF-7 and T-47D cells in a homotypic three-dimensional spheroid cell culture model mimicking a micro tumour environment. Gal-1 inhibited proliferation of MCF-7 cells (strong expression of the TF epitope) but did not significantly change proliferation of T-47D cells (weak expression of the TF epitope). The incubation of MCF-7 cells with gal-1 raised number of apoptotic cells significantly. Treating the spheroids with 30 μg/ml galectin-1 in addition to standard chemotherapeutic regimes (FEC, TAC) resulted in further suppression of the metabolic activity in MCF-7 cells whereas T-47D cells were not affected. Our results demonstrate that galectin-1 can inhibit proliferation und metabolic cell activity and induce

  7. An acoustic eikonal equation for attenuating transversely isotropic media with a vertical symmetry axis

    KAUST Repository

    Hao, Qi

    2016-11-21

    Seismic-wave attenuation is an important component of describing wave propagation. Certain regions, such as gas clouds inside the earth, exert highly localized attenuation. In fact, the anisotropic nature of the earth induces anisotropic attenuation because the quasi P-wave dispersion effect should be profound along the symmetry direction. We have developed a 2D acoustic eikonal equation governing the complex-valued traveltime of quasi P-waves in attenuating, transversely isotropic media with a vertical-symmetry axis (VTI). This equation is derived under the assumption that the complex-valued traveltime of quasi P-waves in attenuating VTI media are independent of the S-wave velocity parameter υS0 in Thomsen\\'s notation and the S-wave attenuation coefficient AS0 in Zhu and Tsvankin\\'s notation. We combine perturbation theory and Shanks transform to develop practical approximations to the acoustic attenuating eikonal equation, capable of admitting an analytical description of the attenuation in homogeneous media. For a horizontal-attenuating VTI layer, we also derive the nonhyperbolic approximations for the real and imaginary parts of the complex-valued reflection traveltime. These equations reveal that (1) the quasi SV-wave velocity and the corresponding quasi SV-wave attenuation coefficient given as part of Thomsen-type notation barely affect the ray velocity and ray attenuation of quasi P-waves in attenuating VTI media; (2) combining the perturbation method and Shanks transform provides an accurate analytic eikonal solution for homogeneous attenuating VTI media; (3) for a horizontal attenuating VTI layer with weak attenuation, the real part of the complex-valued reflection traveltime may still be described by the existing nonhyperbolic approximations developed for nonattenuating VTI media, and the imaginary part of the complex-valued reflection traveltime still has the shape of nonhyperbolic curves. In addition, we have evaluated the possible extension of the

  8. Dancing-drawing fields of presence in SeaUnSea

    DEFF Research Database (Denmark)

    Ramsgaard Thomsen, Mette

    2008-01-01

    Dance and architecture have much in common as both are concerned with practices of space. For a dancer, the act of choreography occurs through the unfolding of spaces by means of gesture and embodied movement, whereas for an architect, space is the medium through which form emerges and habitation...... is constructed. For both, the first space of experience is the space of the body. This essay is a writing out of the interstices of these two disciplines as they touch and inform each other in the process and production of SeaUnSea, an interactive dance installation which premiered at Siobhan Davies Studios...... as part of Dance Umbrella in London, October 2006. SeaUnSea is a collaboration between the authors, choreographer Carol Brown and architect Mette Ramsgard Thomsen, working with programmer Chiron Mottram....

  9. A distrofia miotônica ou miotonia atrófica: estudo sintético-crítico

    Directory of Open Access Journals (Sweden)

    Enzo Azzi

    1953-03-01

    Full Text Available O autor, baseado em algumas observações clínicas pessoais, individualiza os elementos principais (atróficos, miotônicos, neurendócrino-vegetativos que se referem à distrofia miotônica, insistindo sôbre a riqueza dos sintomas infundíbulo-hipofisários observados (distrofia adiposogenital, policitemia, perturbações do sono, constante hipoplasia da sela turca que falam em favor de uma meiopragia diencéfalo-hipofisária como mecanismo fisiopatogênico da doença. O autor discute também o problema das relações entre distrofia miotônica e miotonia de Thomsen, concluindo, com base em um de seus casos, pela identidade fundamental das duas formas e, portanto, pela sua unificação.

  10. Use of anti-TNFs for difficult-to-treat urticaria: response to Cooke et al

    Directory of Open Access Journals (Sweden)

    Thomsen SF

    2015-11-01

    Full Text Available Simon Francis Thomsen,1,2 Freja Lærke Sand1,2 1Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark; 2Department of Biomedical Sciences, University of Copenhagen, Copenhagen, DenmarkWe read with interest the recent paper by Cooke et al about the use of biologic agents for intractable urticaria.1 Particularly, the authors reckon that the evidence supporting the use of anti-TNFs is limited by the small numbers of patients in non-controlled studies, often with urticarial disorders not typical of chronic urticaria such as vasculitis and delayed pressure urticaria. However, we want to draw the authors’ and readers’ attention to our report from 2013 about the use of adalimumab and etanercept in 20 patients with chronic urticaria with or without angioedema2 (updated in 2015 with an additional five patients.3View original article by Cooke et al 

  11. The Inter Facility Testing of a Standard Oscillating Water Column (OWC) Type Wave Energy Converter (WEC)

    DEFF Research Database (Denmark)

    Andersen, Morten Thøtt; Thomsen, Jonas Bjerg

    will be refereed to as The Round Robin Programme. The rationale for the work is based on the MaRINET proposal: A key aspect of the standardisation of device testing is that results from independent trials will be compatible between different test centres. Even when similar procedures are followed this may...... not be guaranteed. A specially selected test programme will, therefore, be implemented at certain MaRINET facilities to investigate this matter. Due to budget restrictions only laboratory scale centres can be considered but the open water operators will be consulted continuously during the formalisation...... at Aalborg University, Sohngaardsholmsvej 57, DK-9000 Aalborg. For further information regarding the content of this report please contact Morten Thøtt Andersen (mta@civil.aau.dk) or Jonas Bjerg Thomsen (jbt@civil.aau.dk) from the Department of Civil Engineering....

  12. EURISOL-DS METEX: CERN SAFETY COMMISSION RECOMMENDATIONS

    CERN Document Server

    J.Gulley (CERN: SC/GS)

    Following a request from M. Lindroos (CERN, AB Department) a visit to the EURISOL mercury target experiment atIPUL (Institute of Physics of University of Latvia) outside Riga in Latvia was organized for 17th September 2008 with J.Gulley (CERN Safety Commission, chemical safety expert) accompanied by K. Samec (CERN, AB Department) and K.Thomsen (Paul Scherrer Institute, PSI). The aim of the visit was to provide general recommendations to IPUL on healthand safety issues related to the use of mercury, with the objective being to reduce exposure to acceptable levels, sofar as is reasonably practicable. An in‐depth process safety study using a systematic risk assessment/hazardidentification technique was outside the scope of the study.

  13. Atopic diseases in twins born after assisted reproduction

    DEFF Research Database (Denmark)

    Jäderberg, Ida; Thomsen, Simon F; Kyvik, Kirsten Ohm

    2012-01-01

    Jäderberg I, Thomsen SF, Kyvik KO, Skytthe A, Backer V. Atopic diseases in twins born after assisted reproduction. Paediatric and Perinatal Epidemiology 2012; 26: 140-145. We examined the risk of atopic diseases in twins born after assisted reproduction. Data on atopic diseases and assisted...... reproduction in 9694 twin pairs, 3-20 years of age, from the Danish Twin Registry were collected via multidisciplinary questionnaires. The risk of atopic diseases in twins born after assisted reproduction was compared with the risk in twins born after spontaneous conception using logistic regression...... and variance components analysis. Children born after assisted reproduction did not have a different risk of atopic outcomes (adjusted odds ratios [95% confidence intervals] for asthma: 0.95 [0.85, 1.07], P = 0.403; hay fever: 1.01 [0.86, 1.18], P = 0.918; and atopic dermatitis: 1.02 [0.81, 1.11], P = 0...

  14. The Gambling Reducing Slot Machine

    DEFF Research Database (Denmark)

    Callesen, Mette Buhl; Thomsen, Kristine Rømer; Linnet, Jakob

    2007-01-01

    and willingness to continue gambling. The results may have important implications for understanding how to reduce gambling behavior in pathological gamblers.   [1] Griffiths, M. 1999. Gambling Technologies: Prospects for Problem Gambling. Journal of Gambling Studies, vol. 15(3), pp. 265-283.    ......  The Gambling Reducing Slot Machine - Preliminary results Mette Buhl Callesen, Kristine Rømer Thomsen, Jakob Linnet and Arne Møller The PET Centre, Aarhus University Hospital and Centre of Functionally Integrative Neuroscience, Aarhus, Denmark   Slot machines are among the most addictive forms...... of gambling due to their specific structural characteristics. These include a high event frequency (number of games per minute), a high frequency of small wins and near misses, and auditory as well as visual feedback that reinforce extended gambling behavior [1].   This study focused on gambling behavior...

  15. Pathological Gambling in Parkinson's Disease

    DEFF Research Database (Denmark)

    Callesen, Mette Buhl; Linnet, Jakob; Thomsen, Kristine Rømer

    Pathological Gambling in Parkinson’s Disease Mette Buhl Callesen, Jakob Linnet, Kristine Rømer Thomsen, Albert Gjedde, Arne Møller PET Center, Aarhus University Hospital and Center of Functionally Integrative Neuroscience, Aarhus University.   The neurotransmitter dopamine is central to many...... aspects of human functioning, e.g., reward, learning, and addiction, including Pathological Gambling (PG), and its loss is key to Parkinson’s Disease (PD). PD is a neurodegenrative disorder caused by progressive loss of dopamine-producing cells in the midbrain [1]. One type of treatment of PD symptoms...... occupancy in the striatum in baseline and gambling situations. We will test the hypothesis that PD patients with PG secondary to dopamine agonism release more dopamine during gambling than PD patients without PG, pathological gamblers, and healthy controls. The behavioral subproject 2 uses a slot machine...

  16. Subjectivity in Self-Historicization

    DEFF Research Database (Denmark)

    Folkmann, Mads Nygaard; Jensen, Hans-Christian

    2015-01-01

    The article looks into the flexible and strategically motivated “subjective” selection of historical references in the design and mediation of Camping – a set of living room furniture designed by Jesper K. Thomsen and launched by the retailer Normann Copenhagen in 2009 under the heading “New Danish...... Modern”. Thus, the case is an example of how design history constitutes a discursive and material reservoir which design actors can employ and engage with for their own purposes. Starting out in a formal description of the design, the article analyzes how Camping in its design and mediation deliberately...... play on the consumption of meaning and in this bypasses the stated cultural frame and symbolic meaning of Danish Modern. Camping entails a meaning structure and self-conscious meaning reflection that can be regarded as a discrete and downplayed version of the experimental design that e.g. can be seen...

  17. Use of next generation sequencing to detect biofilm bacteria in a patient with pedicle screw loosening after spine surgery

    DEFF Research Database (Denmark)

    Xu, Yijuan; Thomsen, Trine Rolighed; Lorenzen, Jan

    2016-01-01

    implant-related infection is believed to be linked to pedicle screw loosening after spine surgery. Low-grade bacterial infection can be hard to diagnose and may be undetected by conventional culture based methods. Next generation sequencing (NGS) could help to uncover hidden bacterial infections...... (v.1.20).” Results: “Clinically there were no signs of local or general infection. Serum parameters were normal (C-reactive protein 0.7 mg/L, WBC 6.2 Gpt/L) at revision surgery. No other infectious foci were noticed. Histology showed no signs of infection. Routine microbial culturing was negative......Title: Use of next generation sequencing to detect biofilm bacteria in a patient with pedicle screw loosening after spine surgery: a case report Yijuan Xu1, Trine Rolighed Thomsen1,2, Jan Lorenzen1, Kathrin Chamaon3, Per Trobisch4, Steffen Drange3 1. Danish Technological Institute, Aarhus, Denmark...

  18. On the conceptual distinction of general causality orientations

    DEFF Research Database (Denmark)

    Olesen, Martin Hammershøj

    electronic questionnaires of dispositional personality traits (NEO-FFI) and general causality orientations (GCOS). Proposed separate latent models and alternative shared latent models of the underlying individual differences constructs had been developed in a previous exploratory study (Olesen, Thomsen......, Schnieber & Tønnesvang, under review). The models were tested using confirmatory factor analyses. Results showed that all three causality orientations were distinct from but closely related to personality traits. Hence, integrative efforts are suggested in relation to comprehensive personality frameworks......This study investigates the conceptual overlap and distinction between individual differences in the Five-Factor Model and Self-determination theory. Participants were 223 adults (age mean=43.74; 60.09% women), who originated in a Danish national probability sample. The participants completed...

  19. MicroRNA expression in nodal and extranodal Diffuse Large B-cell Lymphoma

    DEFF Research Database (Denmark)

    Mandrup, Charlotte; Petersen, Anders; Højfeldt, Anne Dirks

    MicroRNA expression in nodal and extranodal Diffuse Large B-cell Lymphoma   C. Mandrup1, A. Petersen1, A. D. Hoejfeldt1, H. F. Thomsen1, J. Madsen1, J. Dahlgaard1, P. Johansen2, A. Bukh1, K. Dybkaer1 and H. E Johnsen1. 1Department of Hematology, 2Pathological Institute, Aalborg Hospital, Aarhus...... University Hospital, Aalborg, Denmark Introduction: The aim of this project was to analyse microRNA (miRNA) expression in nodal and extranodal diffuse large B-cell lymphoma (DLBCL). Manifestation at diagnosis may be nodal and/or extranodal. At present, there are no known determinants for none...... of the manifestations, and no way to predict the potential progression from nodal to extranodal disease. miRNA are small regulatory RNA molecules with core function to repress/cleave sequence complementary mRNA targets. Abnormalities in miRNA genetics and expression are known to affect initiation and development...

  20. Elastic full-waveform inversion of transmission data in 2D VTI media

    KAUST Repository

    Kamath, Nishant

    2014-08-05

    Full-waveform inversion (FWI) has been implemented mostly for isotropic media, with extensions to anisotropic models typically limited to acoustic approximations. Here, we develop elastic FWI for transmitted waves in 2D heterogeneous VTI (transversely isotropic with a vertical symmetry axis) media. The model is parameterized in terms of the P- and S-wave vertical velocities and the P-wave normal-moveout and horizontal velocities. To test the FWI algorithm, we introduce Gaussian anomalies in the Thomsen parameters of a homogeneous VTI medium and perform FWI of transmission data for different configurations of the source and receiver arrays. The inversion results strongly depend on the acquisition geometry and the aperture because of the parameter trade-offs. In contrast to acoustic FWI, the elastic inversion helps constrain the S-wave vertical velocity, which for our model is decoupled from the other parameters.

  1. BOOK REVIEW: Silvio Waisbord:Reinventing Professionalism: Journalism and News in a Global Perspective

    DEFF Research Database (Denmark)

    Thomsen, Line Hassall

    2015-01-01

    Has new media made us all journalists now? What makes someone a journalist anyway? Is journalism a profession? And if so, what makes a journalist professional? Today, as traditional journalism is challenged by the ever-changing and ever-increasing media market, journalists and journalism...... researchers are constantly questioning the professionalism of journalism. Silvio Waisbord's new book provides an excellent exploration of answers to questions such as these. I was particularly curious to read Waisbord's book, having just finished my PhD thesis (Thomsen, 2013) about the professional values...... of broadcast journalists. During the writing of my PhD, I had searched in vain for a current reference book that provided a thorough review of the history, meanings and expectations of professionalism in journalism today...

  2. Electronic Properties of High-Tc Superconductors. The Normal and the Superconducting State of High-Tc Materials. Proceedings of the International Winter School held in Kirchberg, Tyrol on March 7 - 14, 1992

    Science.gov (United States)

    1992-03-14

    Obermayer, and K.F. Renk, Solid State Commun. 78, 65 (1991). [6] R. Liu, C. Thomsen, W. Kress, M. Cardona, B. Gegenheimer, F.W. de Wette, J. Prade , A.D...Kampf, Angew Cheinie 100. 604 (1988) 9 J1 Prade . A D Kulkarni, F.W~de Wette. U.Schrbder, and W.Kress. Phys Rev B 39, 2771 (1989) 10 P Uiini in ’Oxygen...sv’qten15 at tempe-iratimC 7. Willi the aid of’ V q. (3), resvealing to thle anisotropic case yields 2 2 /2 2 - A if-k 4A’f~k11 M~ire kil 211o) Ini

  3. The Study of Prehistoric Artefacts in National Context: Belgian Archaeologists and the Problem of Ancient Stone Implements

    Directory of Open Access Journals (Sweden)

    Matthew R. Goodrum

    2013-09-01

    Full Text Available During the early nineteenth century European archaeologists were formulating new ideas about the significance of ancient stone artefacts. Some, such as Christian Thomsen in Copenhagen, believed that in Scandinavia, a Stone Age had preceded the Bronze and Iron Ages. In France some excavations had retrieved stone artefacts from deep levels of peat and cave deposits that suggested that these objects were of very great antiquity. While the collection and study of stone artefacts occurred across much of Europe, there were regional variations in their interpretation. Assisted by local institutions and motivated by patriotism, Belgian archaeologists who participated in this research, had much in common with their colleagues elsewhere in Europe, but the nature of local archaeological sites and the ideas of local researchers had an impact on the development and contributions of Belgian prehistoric archaeology.

  4. Medicolegal investigation of political killings in El Salvador.

    Science.gov (United States)

    Thomsen, J L; Gruschow, J; Stover, E

    1989-06-17

    An axiom of Thomas Hobbes states that "people are never more helpless than when the force meant to protect their rights turns against them." Hobbes' axiom holds true today, with Amnesty International reporting that hundreds of thousands have been murdered by their governments. This article examines the medicolegal aspects of an investigation into the deaths of two Salvadoran peasants who were reportedly tortured and executed by soldiers in February 1988. One of the authors, Thomsen, participated in the investigation as a court-ordered expert, and as a representative of the American Association for the Advancement of Science and of a Salvadoran legal aid organization. His necropsy findings are reported with observations and comments. The article concludes with suggestions for initiatives that might be undertaken by individual physicians and institutions to improve the quality and impartiality of medicolegal investigations into political killings.

  5. Making Sense of Facebook

    DEFF Research Database (Denmark)

    Aaen, Janus Holst

    2015-01-01

    The objective of this paper is to discuss a methodological design developed to analyse self-governed student Facebook groups as a part of a larger study of the use of ICT in Danish secondary schools (Mathiasen. Aaen, Dalsgaard, Degn & Thomsen, 2014). The paper will discuss how this methodological...... setup can help the researcher gain in-depth knowledge of the students’ use of Facebook groups, looking past the traditional dichotomy between online and offline as well as the distinction between school-related and non-school-related communication. The paper will address the potential shortcomings...... of the design as well as how the approach can be further developed, and suggests 1) broadening the scope of the study from the Facebook group as a singular medium to include other media used by the students and 2) extending the study to include the voice of students by engaging them as co-researchers....

  6. Negotiating Family Tracking

    DEFF Research Database (Denmark)

    Albrechtslund, Anders; Bøge, Ask Risom; Sonne Damkjær, Maja

    This presentation explores the question: What motivates the use of tracking technologies in families, and how does the use transform the relations between parent and child? The purpose is to investigate why tracking technologies are used in families and how these technologies potentially change...... the relation between parents and children. The use of tracking technologies in families implicate negotiations about the boundaries of trust and intimacy in parent-child relations which can lead to strategies of resistance or modification (Fotel and Thomsen, 2004; Rooney, 2010; Steeves and Jones, 2010......). In the presentation, we report from a qualitative study that focuses on intergenerational relations. The study draws on empirical data from workshops with Danish families as well as individual and group interviews. We aim to gain insights about the sharing habits and negotiations in intimate family relations...

  7. Urban sharing culture

    DEFF Research Database (Denmark)

    Fjalland, Emmy Laura Perez

    In urban areas sharing cultures, services and economies are rising. People share, rent and recycle their homes, cars, bikes, rides, tools, cloths, working space, knowhow and so on. The sharing culture can be understood as mobilities (Kesselring and Vogl 2013) of goods, values and ideas reshaping...... our cities. The sharing economy has the power to democratise access the urban space, resources and raw materials (Steen Nielsen 2008; Harvey 2000); it holds the ability to change the current dominant understandings and structures of economy and growth (Steen Nielsen 2008); solve emerging environmental...... and trust. (Thomsen 2013; Bauman 2000; Beck 1992; Giddens 1991). The sharing economy is currently hyper trendy but before claiming capitalism as dead we need to understand the basics of the sharing economies and cultures asking who can share and what will we share. Furthermore it is crucial to study what...

  8. Laboratory Experiments Enabling Electron Beam use in Tenuous Space Plasmas

    Science.gov (United States)

    Miars, G.; Leon, O.; Gilchrist, B. E.; Delzanno, G. L.; Castello, F. L.; Borovsky, J.

    2017-12-01

    A mission concept is under development which involves firing a spacecraft-mounted electron beam from Earth's magnetosphere to connect distant magnetic field lines in real time. To prevent excessive spacecraft charging and consequent beam return, the spacecraft must be neutralized in the tenuous plasma environment of the magnetosphere. Particle-In-Cell (PIC) simulations suggest neutralization can be accomplished by emitting a neutral plasma with the electron beam. Interpretation of these simulations also led to an ion emission model in which ion current is emitted from a quasi-neutral plasma as defined by the space charge limit [1,2]. Experiments were performed at the University of Michigan's Plasmadynamics and Electric Propulsion Laboratory (PEPL) to help validate the ion emission model. A hollow cathode plasma contactor was used as a representative spacecraft and charged with respect to the chamber walls to examine the effect of spacecraft charging on ion emission. Retarding Potential Analyzer (RPA) measurements were performed to understand ion flow velocity as this parameter relates directly to the expected space charge limit. Planar probe measurements were also made to identify where ion emission primarily occurred and to determine emission current density levels. Evidence of collisions within the plasma (particularly charge exchange collisions) and a simple model predicting emitted ion velocities are presented. While a detailed validation of the ion emission model and of the simulation tools used in [1,2] is ongoing, these measurements add to the physical understanding of ion emission as it may occur in the magnetosphere. 1. G.L. Delzanno, J.E. Borovsky, M.F. Thomsen, J.D. Moulton, and E.A. MacDonald, J. Geophys. Res. Space Physics 120, 3647, 2015. 2. G.L. Delzanno, J.E. Borovsky, M.F. Thomsen, and J.D. Moulton, J. Geophys. Res. Space Physics 120, 3588, 2015. ________________________________ * This work is supported by Los Alamos National Laboratory.

  9. Evaluation of the Jones jig appliance for distal molar movement.

    Science.gov (United States)

    Brickman, C D; Sinha, P K; Nanda, R S

    2000-11-01

    The purpose of this study was to determine the effects of the Jones jig appliance on distal movement of maxillary molars and reciprocal effects on premolars and maxillary incisors. Cephalometric radiographs before and after orthodontic treatment of 72 consecutively treated patients, 46 females and 26 males, were measured to define treatment changes attributed to the Jones jig. Comparative measurements were made on a matched sample of 35 patients (20 females and 15 males) treated with cervical headgear by the same clinician. Both series of patients were treated to correct an Angle Class II molar relationship. The molar correction in the Jones jig patients consisted primarily of molar distal movement. Dental, soft tissue, and skeletal changes were evaluated and compared for significant differences between techniques. The results from the Jones jig sample showed the mean maxillary first molar distal movement was 2.51 mm, with distal tipping of 7.53 degrees. The mean reciprocal mesial movement of the maxillary premolar was 2.0 mm, with mesial tipping of 4.76 degrees. The maxillary first molar extruded 0.14 mm; the maxillary premolar extruded 1.88 mm. The maxillary second molars were also moved distally 2.02 mm and tipped distally 7.89 degrees. The longitudinal assessment (initial to completion of orthodontic treatment) showed significant differences between the Jones jig sample and the cervical headgear sample for lower lip to E-line and SNA. The Jones jig sample showed a mean decrease in lower lip to E-line of 0.25 mm versus 1.20 mm (P jig sample versus 1.20 degrees (P jig sample and cervical headgear sample did not show significant differences of the final position in either linear or angular measurements of the maxillary first molars and corresponding premolar-incisor anchor units. The Jones jig appliance demonstrated treatment results comparable with those of the sample treated with cervical headgear. The Jones jig sample demonstrated effective distal molar

  10. Synthetic digital radiographs using exposure computer models of Voxels / EGS4 Phantoms

    International Nuclear Information System (INIS)

    Kenned, Roberto; Vieira, Jose W.; Lima, Fernando R.A.; Loureiro, Eduardo

    2008-01-01

    The objective of this work is to produce synthetic digital radiographs from synthetic phantoms with the use of a Computational Model of Exposition (MCE). The literature explains a model consisted on a phantom, a Monte Carlo code and an algorithm of a radioactive source. In this work it was used the FAX phantom (Female Adult voXel), besides the EGS4 system code Eletron Shower-range version 4) and an external source, similar to that used in diagnostic radiology. The implementation of MCE creates files with information on external energy deposited in the voxels of fantoma used, here called EnergiaPorVoxel.dat. These files along with the targeted phantom (fax.sgi) worked as data entry for the DIP software (Digital Imaging Processing) to build the synthetic phantoms based on energy and the effective dose. This way you can save each slice that is the stack of pictures of these phantoms synthetics, which have been called synthetic digital radiography. Using this, it is possible to use techniques of emphasis in space to increase the contrast or elineate contours between organs and tissues. The practical use of these images is not only to allow a planning of examinations performed in clinics and hospitals and reducing unnecessary exposure to patients by error of radiographic techniques. (author)

  11. A comparison of sole carbon source utilization patterns and phospholipid fatty acid profiles to detect changes in the root microflora of hydroponically grown crops.

    Science.gov (United States)

    Khalil, S; Bååth, E; Alsanius, B; Englund, J E; Sundin, P; Gertsson, U E; Jensén, P

    2001-04-01

    Sole carbon source utilization (SCSU) patterns and phospholipid fatty acid (PLFA) profiles were compared with respect to their potential to characterize root-inhabiting microbial communities of hydroponically grown crops. Sweet pepper (Capsicum annum cv. Evident), lettuce (Lactuca sativa cv. Grand Rapids), and four different cultivars of tomato (Lycopersicon esculentum cvs. Gitana, Armada, Aromata, and Elin) were grown in 1-L black plastic beakers placed in a cultivation chamber with artificial light. In addition to the harvest of the plants after 6 weeks, plants of one tomato cultivar, cv. Gitana, were also harvested after 4 and 8 weeks. The cultivation in this study was performed twice. Principal component analysis was used to analyze the data. Both characterization methods had the ability to discriminate between the root microflora of different plant species, cultivars, and one tomato cultivar at different ages. Differences in both SCSU patterns and PLFA profiles were larger between plant species than between cultivars, but for both methods the largest differences were between the two cultivations. Still, the differences between treatments were always due to differences in the same PLFAs in both cultivations. This was not the case for the SCSU patterns when different plant ages were studied. Furthermore, PLFA profiles showed less variation between replicates than did SCSU patterns. This larger variation observed among the SCSU data indicates that PLFA may be more useful to detect changes in the root microflora of hydroponically grown crops than the SCSU technique.

  12. The case for small-scale domestic cannabis cultivation.

    Science.gov (United States)

    Decorte, Tom

    2010-07-01

    The shift to (inter)regional production, trade and domestic cultivation has become an irreversible international trend. Until now, the focus of most empirical work has been on large-scale, commercially oriented and professionally organized segments of the cannabis industry, often based on police data and on the perspective of law enforcement agencies. This paper offers a review of recent Dutch-language research that focuses on cannabis cultivation. Empirical studies were identified through literature searches using relevant search terms and Web of Science, Elin, Social Science Research Network and Elsevier ScienceDirect. The paper presents the main findings of Dutch and Belgian empirical work on the factors that stimulated the import substitution process on the cannabis market, aspects related to quality and potency issues, typologies of cannabis growers, and (unintended) effects of pursued policies. In the light of this (selective) review the author offers some commentary and analysis concerning the claims made by different stakeholders, and concludes with some reflections on future research and on policy implications. The author outlines the importance of small-scale, independent or ideologically oriented cannabis cultivation as an under-researched market segment. The author also makes a case for greater toleration of small-scale cannabis cultivation, to secure the least worst of cannabis markets. Copyright (c) 2010 Elsevier B.V. All rights reserved.

  13. Uue põlvkonna ootel : Eesti näitekirjandus 2009 / Ott Karulin

    Index Scriptorium Estoniae

    Karulin, Ott, 1980-

    2010-01-01

    Ülevaade 2009. aasta eesti näitekirjandusest. Pikemalt käsitletakse järgmisi autoreid ja nende näidendeid/näidendikogumikke ning lavastusi: Madis Kõiv "Küüni täitmine", "Näidendid III", "Kolmekesi toas"; Andrus Kivirähk "Vombat", "Ingel, ingel vii mind taeva", "Vassiljev ja Bubõr tegid siia ...", "Limpa ja mereröövlid", "Vanamehed seitsmendalt"; Mart Kivastik "Käsu Hansu ajalootund"; Urmas Lennuk "Igavene kapten", koos Andry Ervaldiga "Jäneste kirik", dramatiseering N. Leskovi "Mtsenski maakonna leedi Machbeth'ist"; Urmas Vadi "Ballettmeister"; Andres Noormets "Öö", "Vaikus ja karjed" (kuuldemängud); Roy Strider "Mässajad"; Uku Uusberg "Pea vahetus"; Tooma Kall "Prügikast 3 ehk Eesti masurka"; Enn Vetemaa "Väike näidendiraamat VI", "Gustav Naani hiilgus ja viletsus", "Ühekäeline bandiit"; Merle Karusoo "Sigma Tau-C705"; Arvo Valton-Vallikivi "Stsenaariumid. Näidendid" ; Silvia Soro "Nähtmatu varandus"; Martin Algus "Postmodernsed leibkonnad"

  14. An Evaluation of the Errors in Cephalometric Measurements on Scanned Lateral Cephalometric Images using Computerized Cephalometric Program and Conventional Tracings

    Directory of Open Access Journals (Sweden)

    Priteshkumar Sureshchand Ganna

    2014-01-01

    Full Text Available Aim and objective: The aim of this study was to compare the cephalometric measurements using Nemoceph software with manual tracings. Materials and methods: The sample consisted of 60 lateral Cephalometric radiographs of patients randomly selected from the existing records of patients of Department of Orthodontics and Dentofacial Orthopedics, KVG Dental College and Hospital, Sullia, Dakshina Kannada. Nineteen angular and 11 linear measurements were analyzed on each radiograph. All the lateral cephalographs were hand-traced and the same Cephalographs were then scanned and were then digitally traced with Nemoceph software. The results were then tabulated in Microsoft excel. The level of significance (p-value was 0.05 and was set at p < 0.05. Paired t-test was performed using SPSS software for comparison between tracing done by manual method and by Nemoceph software. Results: Significant differences were found between the two methods for five (four angular and one linear out of 30 measurements. Those five were saddle angle, articular angle, upper lip to E-Line, Frankfort horizontal to lower incisor axis angle and lower incisor axis to mandibular plane angle. Conclusion: Both angular and linear measurements were accurate and reliable. Except, few measurements showing highly significant differences, the validity of the measurements with the Nemoceph software and with the conventional method were highly correlated.

  15. Genitofemoral neuralgia: adding to the burden of chronic vulvar pain

    Directory of Open Access Journals (Sweden)

    Verstraelen H

    2015-11-01

    Full Text Available Hans Verstraelen,1 Eline De Zutter,1 Martine De Muynck2 1Department of Obstetrics and Gynaecology, Vulvovaginal Disease Clinic, Ghent University Hospital, Ghent, Belgium; 2Department of Physical Medicine and Rehabilitation, Ghent University Hospital, Ghent, Belgium Abstract: The vulva is a particularly common locus of chronic pain with neuropathic characteristics that occurs in women of any age, though most women with neuropathic type chronic vulvar pain will remain undiagnosed even following multiple physician visits. Here, we report on an exemplary case of a middle-aged woman who was referred to the Vulvovaginal Disease Clinic with debilitating vulvar burning and itching over the right labium majus that had been persisting for 2 years and was considered intractable. Careful history taking and clinical examination, followed by electrophysiological assessment through somatosensory evoked potentials was consistent with genitofemoral neuralgia, for which no obvious cause could be identified. Adequate pain relief was obtained with a serotonin–noradrenaline reuptake inhibitor and topical gabapentin cream. We briefly discuss the epidemiology, diagnosis, and treatment of genitofemoral neuralgia and provide a series of clues to guide clinicians in obtaining a presumptive diagnosis of specific neuropathic pain syndromes that may underlie chronic vulvar pain. We further aim to draw attention to the tremendous burden of chronic, unrecognized vulvar pain. Keywords: vulvar pain, genitofemoral nerve, neuropathic pain, vulvodynia, vulvar disease

  16. Kuidas sünnib pealkiri? / Pärt Lias

    Index Scriptorium Estoniae

    Lias, Pärt

    2002-01-01

    Pealkiri, pühendus, moto, joonealune märge, ees- ja järelsõna on teose teksti manused, mis ei kuulu otse teksti, kuid selgitavad, täiendavad ja täpsustavad seda. Gerard Genette on need teksti lisandid koondanud üldnimetuse paratekstid alla. Eesti kirjanikud vastavad Pärt Liase küsimusele oma teoste pealkirjade saamisloo kohta: Aimee Beekman, Henn-Kaarel Hellat, Joel Sang ja Arvo Mägi (4); Lennart Meri, Heino Kiik ja Fanny de Sivers (5); Helga Nõu, Ülle Kauksi, Maie Kalda ja Cornelius Hasselblatt (6); Debora Vaarandi, Vaino Vahing, Arved Viirlaid ja Wimberg (7); Vahur Afanasjev, Matt Barker, Andrus Kivirähk, Jürgen Rooste ja Contra (8); Elin Toona, Jaak Rähesoo, Enn Soosaar, Juhan Peegel ja Toomas Kall (9); Kerttu Rakke, Aare Pilv, Aarne Ruben, Indrek Hargla, Jan Kaus ja Karen Orlau (10); Ene Mihkelson, Mats Traat ja Boriss Baljasnõi (11); Maimu Berg, Ain Kaalep, Enn Nõu ja Madis Kõiv (12)

  17. Wigs, laughter, and subversion: Charles Busch and strategies of drag performance.

    Science.gov (United States)

    Niles, Richard

    2004-01-01

    This paper examines the strategies of drag performer/ playwright Charles Busch. His performance aesthetic is explored and shown to be subversive even though its initial impulse is to entertain. Basing my arguments on the work of Judith Butler, Elin Diamond, and others, I argue that drag queens like Busch can not only entertain but also make audiences question and criticize through drag's power to create a Brechtian alienation effect and historicize the subject. After showing how he can be viewed as a drag queen, I give a brief biography and discuss such contested terms as "camp" and "gay sensibility." I then focus on Busch's staged reading of Ibsen's Hedda Gahler andA Doll's House, both done in one afternoon at Theatre for The New City (6 May 2000). By examining the performance of Busch and his fellow actors, I demonstrate how a contemporary relevancy is achieved by having the roles played by a female impersonator whose acting choices are filtered through a gay sensibility. The ongoing dialectic between spectator and performer creates a historicized moment in performance that underscores the gender dynamics in unexpected and stimulating ways.

  18. Dealing with grief related to loss by death and chronic pain: An integrated theoretical framework. Part 1

    Directory of Open Access Journals (Sweden)

    Bodil Furnes

    2010-05-01

    Full Text Available Bodil Furnes, Elin DysvikUniversity of Stavanger, Faculty of Social Sciences, Department of Health Studies, Stavanger, NorwayObjective: Based on the present authors’ research and several approaches to grief related to loss by death and nonmalignant chronic pain, the paper suggests a new integrated theoretical framework for intervention in clinical settings.Methods: An open qualitative review of the literature on grief theories was performed searching for a new integrated approach in the phenomenological tradition. We then investigated the relationship between grief, loss and chronic nonmalignant pain, looking for main themes and connections and how these could be best understood in a more holistic manner.Results: Two main themes were formulated, “relearning the world” and “adaptation”. Between these themes a continuous movement emerged involving experience such as: “despair and hope”, “lack of understanding and insight”, “meaning disruption and increased meaning”, and “bodily discomfort and reintegrated body”. These were identified as paired subthemes.Conclusions: Grief as a distinctive experience means that health care must be aimed at each individual experience and situation. Grief experience and working with grief are considered in terms of relearning the world while walking backwards and living forwards, as described in our integrated model. We consider that this theoretical framework regarding grief should offer an integrated foundation for health care workers who are working with people experiencing grief caused by death or chronic pain.Keywords: health care, loss, grief

  19. Galeriid - Tallinna kunstisoonel / Andri Ksenofontov

    Index Scriptorium Estoniae

    Ksenofontov, Andri, 1962-

    2005-01-01

    Valgusfestival Tallinnas, Angelika Schneideri joonistuste näitus "Valgest mustani" Estonia Kontserdisaali fuajees, Liina Vedleri näitus "Raskolnikova saar" EKA galeriis, Maria Valdma näitus "Fiktsioonid" Tallinna Linnagaleriis, Eveli Variku näitus "Armuke" Kunstihoone galeriis, Tarmo Roosimöldri näitus "Paus" ning Kaarina Ormio, Jaan Pärnamäe ja Elin T. Sorenseni installatsioon "Mäng" G-galeriis, šveitsi-soome fotograafi Peter Strebeli näitus "Maroko Anti-Atlase mäestiku motiivid" Kiek in de Kökis, Jaan Künnapi Tallinna panoraam näitusel "Tallinn, inimesed ja linn 1878-2002" Raevangla Fotomuuseumis, TPÜ üliõpilaste fotonäitus "Fotofinish" fotokeldris Lee, TPÜ kunstiosakonna üliõpilaste näitus "Tehnika ja lüürika" Viviann Napa galeriis, näitus "Juugendstiil Lätis", Pille Kivihalli, Maarja Unduski ja Tiina Piisangu näitus "Altar raamatule" rahvusraamatukogus, Toomas Keldri mälestusnäitus disaini- ja arhitektuurigaleriis, Irina Ishina näitus Vene saatkonna galeriis, Vladimir Baciu näitus Haus galeriis, Vassili Gretshko näitus Artline'i galeriis, Jana Wiebe ja Tjika Rebase "Surnuaia kogumik vol. 1" Hobusepea galeriis, Kadi Kurema näitus "Imeasjad" Ühispanga galeriis ja "Pisiasjad" Galeriis 36

  20. Local effect of celecoxib on peripheral nerve repair combined with silicone tubulization in rat

    Directory of Open Access Journals (Sweden)

    Mohammadi Rahim

    2013-10-01

    Full Text Available 【Abstract】Objective: To assess local effect of celecoxib on nerve regeneration in a rat sciatic nerve transection model. Methods: Forty-five male healthy white Wistar rats were randomly divided into three experimental groups (n=15 for each: sham-oper ation (SHAM, control (SIL and celecoxib treated (SIL/CLX groups. In SHAM group after anesthesia left sciatic nerve was exposed and after homeostasis muscle was sutured. In SIL group the left sciatic nerve was exposed in the same way and transected proximal to tibioperoneal bifurcation leaving a 10 mm gap. Proximal and distal stumps were each inserted into a silicone tube and filled with 10 µl phosphate buffered solution. In SIL/CLX group defect was bridged using a silicone tube filled with 10 µl celecoxib (0.1 g/L. Results: Functional study and gastrocnemius muscle mass confirmed faster and better recovery of regenerated axons in SIL/CLX than in SIL group(P<0.05. Morphometric indices of regenerated fibers showed number and diameter of the my elinated fibers in SIL/CLX were significantly greater than those in control group. In immunohistochemistry, location of reactions to S-100 in SIL/CLX was clearly more positive than that in SIL group. Conclusion: Response to local treatment of celecoxib demonstrates that it influences and improves functional recovery of peripheral nerve regeneration. Key words: Peripheral nerve; Sciaticnerve; Celecoxib; Nerve regeneration

  1. Eesti kunsti näitused Ameerikas

    Index Scriptorium Estoniae

    2006-01-01

    23. II-12. III New Yorgis ÜRO peakorteris näitus "Käemaastikud/Handscapes". Vaadata on fotod, maalid ja installatsioonid. Kuraator Elin Kard, osalevad Jüri Ojaver, Ülle Marks, Jüri Kass, Alice Kask. 24. III-21. IV New Yorgi Eesti Majas Eesti Kultuurifondi ja Eesti kultuuripäevade näitus "Lõõm 06. Kunstidialoog: New York - Estonia". Jaanika Peerna kureeritud näitusel osalevad eesti ja ameerika kunstnikud Peeter Kolk, Dianne Bowen, Külliki Talp, Ilse Leetaru, Mark Kostabi, Paul Indrek Kostabi, Kristjan Jüris, Erika Roots, Endel Uiga, J. Peerna, Victoria Schultz, Leevi Ernits, Kristiana Pärn, Naima Rauam, Patrick Kikut, Ave Barker, Epp Kuhn, Triinu Jenas. Avamisel esilinastub J. Peenra ja Annette Solakoglu (sünd. 1968, Rootsi) lühifilm "Lõõm 06". Phoenixi Cathedral Center for the Artsis oli 3. II-1. III Anne Parmasto maalinäitus Charlotte'i aed"

  2. Reactive transport simulation via combination of a multiphase-capable transport code for unstructured meshes with a Gibbs energy minimization solver of geochemical equilibria

    Science.gov (United States)

    Fowler, S. J.; Driesner, T.; Hingerl, F. F.; Kulik, D. A.; Wagner, T.

    2011-12-01

    We apply a new, C++-based computational model for hydrothermal fluid-rock interaction and scale formation in geothermal reservoirs. The model couples the Complex System Modelling Platform (CSMP++) code for fluid flow in porous and fractured media (Matthai et al., 2007) with the Gibbs energy minimization numerical kernel GEMS3K of the GEM-Selektor (GEMS3) geochemical modelling package (Kulik et al., 2010) in a modular fashion. CSMP++ includes interfaces to commercial file formats, accommodating complex geometry construction using CAD (Rhinoceros) and meshing (ANSYS) software. The CSMP++ approach employs finite element-finite volume spatial discretization, implicit or explicit time discretization, and operator splitting. GEMS3K can calculate complex fluid-mineral equilibria based on a variety of equation of state and activity models. A selection of multi-electrolyte aqueous solution models, such as extended Debye-Huckel, Pitzer (Harvie et al., 1984), EUNIQUAC (Thomsen et al., 1996), and the new ELVIS model (Hingerl et al., this conference), makes it well-suited for application to a wide range of geothermal conditions. An advantage of the GEMS3K solver is simultaneous consideration of complex solid solutions (e.g., clay minerals), gases, fluids, and aqueous solutions. Each coupled simulation results in a thermodynamically-based description of the geochemical and physical state of a hydrothermal system evolving along a complex P-T-X path. The code design allows efficient, flexible incorporation of numerical and thermodynamic database improvements. We demonstrate the coupled code workflow and applicability to compositionally and physically complex natural systems relevant to enhanced geothermal systems, where temporally and spatially varying chemical interactions may take place within diverse lithologies of varying geometry. Engesgaard, P. & Kipp, K. L. (1992). Water Res. Res. 28: 2829-2843. Harvie, C. E.; Møller, N. & Weare, J. H. (1984). Geochim. Cosmochim. Acta 48

  3. Plasma Transport and Magnetic Flux Circulation in Saturn's Magnetosphere

    Science.gov (United States)

    Neupane, B. R.; Delamere, P. A.; Ma, X.; Wilson, R. J.

    2017-12-01

    Radial transport of plasma in the rapidly rotating magnetospheres is an important dynamical process. Radial transport is due to the centrifugally driven interchange instability and magnetodisc reconnection, allowing net mass to be transported outward while conserving magnetic flux. Using Cassini Plasma Spectrometer instrument (CAPS) data products (e.g., Thomsen et al., [2010]; Wilson et al., [2017]) we estimate plasma mass and magnetic flux transport rates as functions of radial distance and local time. The physical requirement for zero net magnetic flux transport provides a key benchmark for assessing the validity of our mass transport estimate. We also evaluate magnetodisc stability using a two-dimensional axisymmetric equilibrium model [Caudal, 1986]. Observed local properties (e.g., specific entropy and estimates of flux tube mass and entropy content) are compared with modeled equilibrium conditions such that departures from equilibrium can be correlated with radial flows and local magnetic field structure. Finally, observations of specific entropy indicate that plasma is non-adiabatic heated during transport. However, the values of specific entropy are well organized in inner magnetosphere (i.e. L<10), and become widely scattered in the middle magnetosphere, suggesting that the transport dynamics of the inner and middle magnetosphere are different.

  4. Spectrum of Nondystrophic Skeletal Muscle Channelopathies in Children.

    Science.gov (United States)

    Al-Ghamdi, Fouad; Darras, Basil T; Ghosh, Partha S

    2017-05-01

    The nondystrophic skeletal muscle channelopathies are a group of disorders caused by mutations of various voltage-gated ion channel genes, including nondystrophic myotonia and periodic paralysis. We identified patients with a diagnosis of muscle channelopathy from our neuromuscular database in a tertiary care pediatric center from 2005 to 2015. We then performed a retrospective review of their medical records for demographic characteristics, clinical features, investigations, treatment, and follow-up. Thirty-three patients were identified. Seventeen had nondystrophic myotonia. Seven of them had chloride channelopathy (four Becker disease and three Thomsen disease). Warm-up phenomenon and muscle hypertrophy were common clinical manifestations in this subgroup. Ten patients had sodium channelopathy (four paramyotonia congenita and six other sodium channel myotonia). Stiffness of the facial muscles was an important presenting symptom, and eyelid myotonia was a common clinical finding in this subgroup. The majority of these patients had electrical myotonia. Mexiletine was effective in controlling the symptoms in patients who had received treatment. Sixteen children had periodic paralysis (four hyperkalemic periodic paralysis, eight hypokalemic periodic paralysis, and four Andersen-Tawil syndrome). Acetazolamide was commonly used to prevent paralytic attacks and was found to be effective. Nondystrophic muscle channelopathies present with diverse clinical manifestations (myotonia, muscle hypertrophy, proximal weakness, swallowing difficulties, and periodic paralysis). Cardiac arrhythmias are potentially life threatening in Andersen-Tawil syndrome. Timely identification of these disorders is helpful for effective symptomatic management and genetic counseling. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. The treatment effects of Invisalign orthodontic aligners: a systematic review.

    Science.gov (United States)

    Lagravère, Manuel O; Flores-Mir, Carlos

    2005-12-01

    The authors conducted a systematic review of the literature to determine the treatment effects of the Invisalign orthodontic system (Align Technology), Santa Clara, Calif.). The authors reviewed clinical trials that assessed Invisalign's treatment effects in nongrowing patients. They did not consider trials involving surgical or other simultaneous fixed or removable orthodontic treatment interventions. The authors searched electronic databases (PubMed, MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, Evidence Based Medicine Reviews, EMBASE Excerpta Medica, Thomsen's ISI Web of Science and LILACS) with the help of a senior health sciences librarian. They used "Invisalign" as the sole search term, and 22 documents appeared in the combined search. Thereafter, they used "clinical trials," "humans" and "Invisalign treatment effects" as abstract selection criteria. Only two published articles met these inclusion criteria, though after reading the actual articles, the authors determined that they did not adequately evaluate Invisalign treatment effects. Both articles identified methodological issues. The inadequately designed studies the authors found represented only a lower level of evidence (level II). Therefore, the authors found that no strong conclusions could be made regarding the treatment effects of Invisalign appliances. Future prospective randomized clinical trials are required to support, with sound scientific evidence, the claims about Invisalign's treatment effects. Clinicians will have to rely on their Invisalign clinical experience, the opinions of experts and the limited published evidence when using Invisalign appliances.

  6. Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR

    Directory of Open Access Journals (Sweden)

    Stefan Hutter

    2016-04-01

    Full Text Available Galectins (gal are members of the mammalian β-galactoside-binding proteins and recognize Galβ1-4GlcNAc and Galβ1-4GalNac (Thomsen-Friedenreich antigen (TF sequences of several cell surface oligosaccharides. In this study, gal-1, -2, -3 and -13 were investigated systematically in the trophoblast and decidua compartment of intrauterine growth restriction (IUGR placentas and normal third trimester control placentas and stratified by fetal gender and gestational age. Within this study, 29 third trimester placentas after delivery were analyzed. Fetal gender was equally divided within both groups, and immunohistochemical staining was analyzed according to fetal gender and gestational age. Double immune-fluorescence with trophoblast-specific markers was used to identify galectin-expressing cells at the feto-maternal interface in the decidua. Gal-3 was significantly downregulated only in the extravillous trophoblast of IUGR placentas. In contrast, expressions of gal-2 and gal-13 were downregulated in both villous and extravillous trophoblast cells of IUGR placentas. In addition, gal-2 and gal-13 showed a highly correlated expression scheme in the placenta. There are significant gender-specific expression patterns for single prototype galectins with downregulation of gal-2 and gal-13 of male gender placentas in cases of IUGR. Gal-3 as the chimera type galectin shows only little gender-specific differences in expression, which disappear in IUGR cases.

  7. Relationship between fasting glucose, vitamin D and PTH in early postmenopausal women

    DEFF Research Database (Denmark)

    við Streym, Susanna; Rejnmark, Lars; Vestergaard, Peter

      Abstract Relationship between fasting glucose, vitamin D and PTH in early postmenopausal women Súsanna við Streym Thomsen (1), Lars Rejnmark (1), Peter Vestergaard (1), Christine Brot (2), Pia Eiken (3), Pernille Hermann (4) Leif Mosekilde (1). (1) Department of Medicine and Endocrinology C...... adjusted for Body Mass Index (BMI), body composition, PTH and physical activity in postmenopausal women. Design: Cross-sectional study in postmenopausal women.  Material and Methods: Data are based on analyses from the Danish Osteoporosis Prevention Study (DOPS), which is a cohort study in early.......036, but not with 25OHD (b=0.001 ±0.002 (SE), 2p=0.643).     The mean and SEM for Glucose was 4.72 mmol/l (± 0.02) and 25OHD 25.1 ng/ml (± 0.3). Conclusion: The apparent relationship between fasting blood glucose and serum 25OHD seems to be mediated by serum PTH, BMI and physical activity. As 25OHD is known...

  8. Dynamic exit-channel pathways of the microsolvated HOO-(H2O) + CH3Cl SN2 reaction: Reaction mechanisms at the atomic level from direct chemical dynamics simulations

    Science.gov (United States)

    Yu, Feng

    2018-01-01

    Microsolvated bimolecular nucleophilic substitution (SN2) reaction of monohydrated hydrogen peroxide anion [HOO-(H2O)] with methyl chloride (CH3Cl) has been investigated with direct chemical dynamics simulations at the M06-2X/6-31+G(d,p) level of theory. Dynamic exit-channel pathways and corresponding reaction mechanisms at the atomic level are revealed in detail. Accordingly, a product distribution of 0.85:0.15 is obtained for Cl-:Cl-(H2O), which is consistent with a previous experiment [D. L. Thomsen et al. J. Am. Chem. Soc. 135, 15508 (2013)]. Compared with the HOO- + CH3Cl SN2 reaction, indirect dynamic reaction mechanisms are enhanced by microsolvation for the HOO-(H2O) + CH3Cl SN2 reaction. On the basis of our simulations, further crossed molecular beam imaging experiments are highly suggested for the SN2 reactions of HOO- + CH3Cl and HOO-(H2O) + CH3Cl.

  9. Sound construction of risk indicators

    DEFF Research Database (Denmark)

    Sørensen, Peter Borgen; Kjær, Christian; Thomsen, Marianne

    that governs the method: HotSpot Driven Aggregation of Risk Indicators (HoSDARI) as described in Sørensen et al. (2008). The purpose of the risk assessment is to protect a defined target that has some value for protection. The target has a number of realizations each defined as a Protection Unit (PU...... indicator values for each of them that can help to find hotspots in risk level. The focus is xenobiotics, but the methodology is useful for many other risk-related problems.   References Sørensen, P.B.; Brüggemann, R; Thomsen M.; Gyldenkærne S.; Kjær C (2008). Aggregation of risk indicators for time trend......  In spite of the great effort in the area of environmental risk assessment of chemicals, a critical amount of uncertainty is still a reality due to high complexity of the governing risk problem. Unexpected adverse effects may thus take place event though the risk assessment predicts no-risk. Some...

  10. Complex Biological Systems Analysis of Cell Cycling Models in Carcinogenesis: I. The essential roles of modifications in the c-Myc, TP53/p53, p27 and hTERT modules in Cancer Initiation and Progression

    CERN Document Server

    Prisecaru, V I

    2004-01-01

    A new approach to the integration of results from a modular, complex biological systems analysis of nonlinear dynamics in cell cycling network transformations that are leading to carcinogenesis is proposed. Carcinogenesis is a complex process that involves dynamically inter-connected biomolecules in the intercellular, membrane, cytosolic, nuclear and nucleolar compartments that form numerous inter-related pathways referred to as networks. One such network module contains the cell cyclins whose functions are essential to cell cycling and division. Cyclins are proteins that also link to several critical pro-apoptotic and other cell cycling/division components, such as: c-Myc, p27, the tumor suppressor gene TP53 and its product-- the p53 protein with key roles in controlling DNA repair, inducing apoptosis and activating p21 (which can depress cell cyclins if activated), mdm2(with its biosynthesis activated by p53 and also, in its turn, inhibiting p53), p21, the Thomsen-Friedenreich antigen(T- antigen),Rb,Bax, Ba...

  11. Taus at ATLAS

    Energy Technology Data Exchange (ETDEWEB)

    Demers, Sarah M. [Yale Univ., New Haven, CT (United States). Dept. of Physics

    2017-12-06

    The grant "Taus at ATLAS" supported the group of Sarah Demers at Yale University over a period of 8.5 months, bridging the time between her Early Career Award and her inclusion on Yale's grant cycle within the Department of Energy's Office of Science. The work supported the functioning of the ATLAS Experiment at CERN's Large Hadron Collider and the analysis of ATLAS data. The work included searching for the Higgs Boson in a particular mode of its production (with a W or Z boson) and decay (to a pair of tau leptons.) This was part of a broad program of characterizing the Higgs boson as we try to understand this recently discovered particle, and whether or not it matches our expectations within the current standard model of particle physics. In addition, group members worked with simulation to understand the physics reach of planned upgrades to the ATLAS experiment. Supported group members include postdoctoral researcher Lotte Thomsen and graduate student Mariel Pettee.

  12. Dynamic exit-channel pathways of the microsolvated HOO-(H2O) + CH3Cl SN2 reaction: Reaction mechanisms at the atomic level from direct chemical dynamics simulations.

    Science.gov (United States)

    Yu, Feng

    2018-01-07

    Microsolvated bimolecular nucleophilic substitution (S N 2) reaction of monohydrated hydrogen peroxide anion [HOO - (H 2 O)] with methyl chloride (CH 3 Cl) has been investigated with direct chemical dynamics simulations at the M06-2X/6-31+G(d,p) level of theory. Dynamic exit-channel pathways and corresponding reaction mechanisms at the atomic level are revealed in detail. Accordingly, a product distribution of 0.85:0.15 is obtained for Cl - :Cl - (H 2 O), which is consistent with a previous experiment [D. L. Thomsen et al. J. Am. Chem. Soc. 135, 15508 (2013)]. Compared with the HOO - + CH 3 Cl S N 2 reaction, indirect dynamic reaction mechanisms are enhanced by microsolvation for the HOO - (H 2 O) + CH 3 Cl S N 2 reaction. On the basis of our simulations, further crossed molecular beam imaging experiments are highly suggested for the S N 2 reactions of HOO - + CH 3 Cl and HOO - (H 2 O) + CH 3 Cl.

  13. Coherent gigahertz phonons in Ge₂Sb₂Te₅ phase-change materials.

    Science.gov (United States)

    Hase, Muneaki; Fons, Paul; Kolobov, Alexander V; Tominaga, Junji

    2015-12-09

    Using ≈40 fs ultrashort laser pulses, we investigate the picosecond acoustic response from a prototypical phase change material, thin Ge2Sb2Te5 (GST) films with various thicknesses. After excitation with a 1.53 eV-energy pulse with a fluence of ≈5 mJ cm(-2), the time-resolved reflectivity change exhibits transient electronic response, followed by a combination of exponential-like strain and coherent acoustic phonons in the gigahertz (GHz) frequency range. The time-domain shape of the coherent acoustic pulse is well reproduced by the use of the strain model by Thomsen et al 1986 (Phys. Rev. B 34 4129). We found that the decay rate (the inverse of the relaxation time) of the acoustic phonon both in the amorphous and in the crystalline phases decreases as the film thickness increases. The thickness dependence of the acoustic phonon decay is well modeled based on both phonon-defect scattering and acoustic phonon attenuation at the GST/Si interface, and it is revealed that those scattering and attenuation are larger in crystalline GST films than those in amorphous GST films.

  14. Sensitivity analysis for elastic full-waveform inversion in VTI media

    KAUST Repository

    Kamath, Nishant

    2014-08-05

    Multiparameter full-waveform inversion (FWI) is generally nonunique, and the results are strongly influenced by the geometry of the experiment and the type of recorded data. Studying the sensitivity of different subsets of data to the model parameters may help in choosing an optimal acquisition design, inversion workflow, and parameterization. Here, we derive the Fréchet kernel for FWI of multicomponent data from a 2D VTI (tranversely isotropic with a vertical symmetry axis) medium. The kernel is obtained by linearizing the elastic wave equation using the Born approximation and employing the asymptotic Green\\'s function. The amplitude of the kernel (‘radiation pattern’) yields the angle-dependent energy scattered by a perturbation in a certain model parameter. The perturbations are described in terms of the P- and S-wave vertical velocities and the P-wave normal-moveout and horizontal velocities. The background medium is assumed to be homogeneous and isotropic, which allows us to obtain simple expressions for the radiation patterns corresonding to all four velocities. These patterns help explain the FWI results for multicomponent transmission data generated for Gaussian anomalies in the Thomsen parameters inserted into a homogeneous VTI medium.

  15. Pneumococcal Induced T-activation with Resultant Thrombotic Microangiopathy

    Directory of Open Access Journals (Sweden)

    J.W. Oliver

    2010-01-01

    Full Text Available Thrombotic microangiopathies are disorders resulting from platelet thromboses forming in the microvasculature with resultant schistocyte forms. Hemolytic uremic syndrome (HUS is a microangiopathic hemolytic anemia often complicated by acute renal failure in children. HUS is typically caused by bacterial infection, most commonly enterohemorrhagic Escherichia coli. Neuraminidase-producing organisms, such as Streptococcus pneumoniae have also been reported as potential etiologies. The pathogenesis in these cases involves cleavage of sialic acid residues from the surfaces of erythrocytes, platelets, and glomerular capillary endothelial cells, exposing the Thomsen-Friedenreich antigen, a process known as T-activation. We describe a 2-year-old girl who presented with pneumococcal pneumonia and sepsis ultimately resulting in a thrombotic microangiopathy with acute renal failure, most consistent with HUS. The patient's direct antiglobulin test was positive. Polyagglutination was observed with human adult serum, but not with umbilical cord serum. Her red blood cells (RBCs were reactive against peanut and soybean lectins, but not Salvia sclarea or Salvia horminum lectins. These findings are consistent with T-activation. Clinicians should be cognizant of the possibility of T-activation with resultant HUS in patients infected with neuraminidase-producing bacteria. Such patients may be difficult to identify using monoclonal typing antisera, as these typically do not have anti-T antibodies. Whether such patients are at risk for transfusion-associated hemolysis is debatable.

  16. Control of the heart rate of rat embryos during the organogenic period

    Directory of Open Access Journals (Sweden)

    Ritchie HE

    2016-11-01

    Full Text Available Helen E Ritchie,1 Carolina Ragnerstam,2 Elin Gustafsson,2 Johanna M Jonsson,2 William S Webster2 1Discipline of Biomedical Science, Sydney Medical School, University of Sydney, Lidcombe, 2Department of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, NSW, Australia Abstract: The aim of this study was to gain insight into whether the first trimester embryo could control its own heart rate (HR in response to hypoxia. The gestational day 13 rat embryo is a good model for the human embryo at 5–6 weeks gestation, as the heart is comparable in development and, like the human embryo, has no functional autonomic nerve supply at this stage. Utilizing a whole-embryo culture technique, we examined the effects of different pharmacological agents on HR under normoxic (95% oxygen and hypoxic (20% oxygen conditions. Oxygen concentrations ≤60% caused a concentration-dependent decrease in HR from normal levels of ~210 bpm. An adenosine agonist, AMP-activated protein kinase (AMPK activator and KATP channel opener all caused bradycardia in normoxic conditions; however, putative antagonists for these systems failed to prevent or ameliorate hypoxia-induced bradycardia. This suggests that the activation of one or more of these systems is not the primary cause of the observed hypoxia-induced bradycardia. Inhibition of oxidative phosphorylation also decreased HR in normoxic conditions, highlighting the importance of ATP levels. The β-blocker metoprolol caused a concentration-dependent reduction in HR supporting reports that β1-adrenergic receptors are present in the early rat embryonic heart. The cAMP inducer colforsin induced a positive chronotropic effect in both normoxic and hypoxic conditions. Overall, the embryonic HR at this stage of development is responsive to the level of oxygenation, probably as a consequence of its influence on ATP production. Keywords: embryonic heart rate, embryo, bradycardia, in vitro, ATP, hypoxia

  17. Loneliness, loss, and social support among cognitively intact older people with cancer, living in nursing homes – a mixed-methods study

    Directory of Open Access Journals (Sweden)

    Drageset J

    2015-09-01

    Full Text Available Jorunn Drageset,1,2 Geir Egil Eide,2,3 Elin Dysvik,4 Bodil Furnes,4 Solveig Hauge51Faculty of Health and Social Sciences, Bergen University College, Bergen, Norway; 2Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; 3Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway; 4Department of Health Studies, Faculty of Social Sciences, University of Stavanger, Stavanger, Norway; 5Faculty of Health and Social Studies and Centre for Caring Research – Southern Norway, Telemark University College, Porsgrunn, NorwayBackground: Loneliness is a significant psychosocial effect following a cancer diagnosis and may prevent people from engaging in social activities, thus creating difficulties in interpersonal relationships. This study investigated loneliness and social support among cognitively intact nursing home residents with cancer by using a quantitatively driven mixed-methods design with sequential supplementary qualitative components.Methods: The quantitative component consisted of face-to-face interviews of 60 nursing home residents (≥65 years using the one-item Loneliness Scale and the Social Provisions Scale. The supplementary psychosocial component consisted of qualitative research interviews about experiences related to loneliness with nine respondents.Results: The quantitative results indicated that reassurance of worth was associated with loneliness. The experience of loneliness was identified by the following: loneliness that was dominated by a feeling of inner pain, feeling of loss, and feeling small. Loneliness was alleviated by the following: being engaged in activities, being in contact with other people, and occupying oneself.Conclusion: Enhancing the lives of nursing home residents with cancer requires attending to the residents’ experience of loneliness and social relationships in a targeted and individualized manner. This might require screening all nursing home residents

  18. Nursing interventions in stroke care delivery: An evidence-based clinical review.

    Science.gov (United States)

    Theofanidis, Dimitrios; Gibbon, Bernard

    2016-12-01

    Generally, nursing interventions during the acute stages following a stroke aim at preventing secondary brain injury (intracranial hypertension), maintaining the airways (due to paralysis of the pharynx muscles), providing general body support (vital signs, fluid and electrolyte balance), and anticipating the occurrence of complications (atelectasis and pneumonia). This literature review is to prioritize nursing interventions for acute stroke and to update nursing roles and input considering recommended levels of evidence of care to date. A systematic review was undertaken, and databases searched were Electronic Library Information Navigator (ELIN), Medline and the Cumulative Index to Nursing and Allied Health Literature from 1990 to 2015, using the OVID interface. The search originally yielded 400 articles of which 65 were selected for analysis and 12 of these included evidence synthesis (class I-IV, level A-Good Clinical Practice [GCP]). To facilitate early patient recovery, advanced nursing care should include the routine practice of a wide range of specific nursing interventions such as continence management, pressure area care, swallowing management, and early mobilization. Other important nursing interventions include the prevention of pulmonary thromboembolism and early antiplatelet therapy. For over 20 years, it has been established that specialized stroke care save lives, reduce disability, shorten length of stay, and generally have been associated with improved patient outcomes. Highly specialized nursing input is of paramount importance in achieving optimum patient outcomes and high quality of interdisciplinary care, providing a comprehensive, interactive, and holistic approach for both acute stroke and rehabilitation. Copyright © 2016 Society for Vascular Nursing, Inc. Published by Elsevier Inc. All rights reserved.

  19. Review: Assessment of completeness of reporting in intervention studies using livestock: an example from pain mitigation interventions in neonatal piglets.

    Science.gov (United States)

    O'Connor, A; Anthony, R; Bergamasco, L; Coetzee, J F; Dzikamunhenga, R S; Johnson, A K; Karriker, L A; Marchant-Forde, J N; Martineau, G P; Millman, S T; Pajor, E A; Rutherford, K; Sprague, M; Sutherland, M A; von Borell, E; Webb, S R

    2016-04-01

    Accurate and complete reporting of study methods, results and interpretation are essential components for any scientific process, allowing end-users to evaluate the internal and external validity of a study. When animals are used in research, excellence in reporting is expected as a matter of continued ethical acceptability of animal use in the sciences. Our primary objective was to assess completeness of reporting for a series of studies relevant to mitigation of pain in neonatal piglets undergoing routine management procedures. Our second objective was to illustrate how authors can report the items in the Reporting guidElines For randomized controLled trials for livEstoCk and food safety (REFLECT) statement using examples from the animal welfare science literature. A total of 52 studies from 40 articles were evaluated using a modified REFLECT statement. No single study reported all REFLECT checklist items. Seven studies reported specific objectives with testable hypotheses. Six studies identified primary or secondary outcomes. Randomization and blinding were considered to be partially reported in 21 and 18 studies, respectively. No studies reported the rationale for sample sizes. Several studies failed to report key design features such as units for measurement, means, standard deviations, standard errors for continuous outcomes or comparative characteristics for categorical outcomes expressed as either rates or proportions. In the discipline of animal welfare science, authors, reviewers and editors are encouraged to use available reporting guidelines to ensure that scientific methods and results are adequately described and free of misrepresentations and inaccuracies. Complete and accurate reporting increases the ability to apply the results of studies to the decision-making process and prevent wastage of financial and animal resources.

  20. Bone and Soft Tissue Changes after Two-Jaw Surgery in Cleft Patients

    Directory of Open Access Journals (Sweden)

    Yung Sang Yun

    2015-07-01

    Full Text Available BackgroundOrthognathic surgery is required in 25% to 35% of patients with a cleft lip and palate, for whom functional recovery and aesthetic improvement after surgery are important. The aim of this study was to examine maxillary and mandibular changes, along with concomitant soft tissue changes, in cleft patients who underwent LeFort I osteotomy and sagittal split ramus osteotomy (two-jaw surgery.MethodsTwenty-eight cleft patients who underwent two-jaw surgery between August 2008 and November 2013 were included. Cephalometric analysis was conducted before and after surgery. Preoperative and postoperative measurements of the bone and soft tissue were compared.ResultsThe mean horizontal advancement of the maxilla (point A was 6.12 mm, while that of the mandible (point B was -5.19 mm. The mean point A-nasion-point B angle was -4.1° before surgery, and increased to 2.5° after surgery. The mean nasolabial angle was 72.7° before surgery, and increased to 88.7° after surgery. The mean minimal distance between Rickett's E-line and the upper lip was 6.52 mm before surgery and 1.81 mm after surgery. The ratio of soft tissue change to bone change was 0.55 between point A and point A' and 0.93 between point B and point B'.ConclusionsPatients with cleft lip and palate who underwent two-jaw surgery showed optimal soft tissue changes. The position of the soft tissue (point A' was shifted by a distance equal to 55% of the change in the maxillary bone. Therefore, bone surgery without soft tissue correction can achieve good aesthetic results.

  1. Quality Of Life and Nursing: a Position Paper

    Directory of Open Access Journals (Sweden)

    Antigoni Fountouki

    2010-01-01

    Full Text Available Introduction: This paper presents a historical review of quality assurance in nursing with terminologicaldefinitions. General issues involving the evaluation of quality of care are discussed and key questions tackled.Aims: The aims of this paper were to critically discuss and analyze the essence of quality as a construct with highrelevance to nursing practice. Also, to look at quality through a series of important benchmark questions such aswho evaluates, who is the evaluated, what is evaluated, whose interests are involved.Methods: An online search in Medline, CINHAL, PsycINFO, ELIN, Embase, and the Cochrane Database ofSystematic Reviews was conducted. Retrieved studies were screened to meet certain inclusion criteria, i.e.relevance, significant meanings in correspondence with this paper’s aims and of interest to an international nursingreadership.Results: Data were abstracted from each paper and tabulated for further discussion and data synthesis. Nurses havebeen fervent supporters of quality assurance as it provides feedback to the profession about its practices andeffectiveness of care. The hospital, as an independent organization in the health care industry, sees nursing as theprovider closest to the consumer so is very concerned with the quality of nursing care. Nurses see through the lensof the customer and understand his or her wants and needs and therefore understand business better than otherproviders.Conclusions: The main conclusion of this position paper is that a major underlying reason for quality of careevaluation is the measurement of costs. As the goal for every successful manager is to minimise costs whilemaintaining quality. This equates nursing evaluation to the evaluation of a business model- a parallel which doesnot appeal to the caring profession of nursing.

  2. Do ultra-orphan medicinal products warrant ultra-high prices? A review

    Directory of Open Access Journals (Sweden)

    Picavet E

    2013-06-01

    Full Text Available Eline Picavet,1 David Cassiman,2 Steven Simoens1 1Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium; 2Department of Hepatology, University Hospital Leuven, Leuven, Belgium Abstract: Ultra-orphan medicinal products (ultra-OMPs are intended for the treatment, prevention, or diagnosis of ultra-rare diseases, ie, life-threatening or chronically debilitating diseases that affect less than one per 50,000 individuals. Recently, high prices for ultra-OMPs have given rise to debate on the sustainability and justification of these prices. The aim of this article is to review the international scientific literature on the pricing of ultra-OMPs and to provide an overview of the current knowledge on the drivers of ultra-OMP pricing. The pricing process of ultra-OMPs is a complex and nontransparent issue. Evidence in the literature seems to indicate that ultra-OMPs are priced according to rarity and what the manufacturer believes the market will bear. Additionally, there appears to be a trend between the price of an ultra-OMP and the number of available alternatives. Patients, third-party payers, and pharmaceutical companies could benefit from more transparent pricing strategies. With a view to containing health care costs, it is likely that cost-sharing strategies, such as performance-based risk sharing arrangements, will become increasingly more important. However, it is vital that any measures for price control are consistent with the intended goals of the incentives to promote the development of new OMPs. Ideally, a balance must be struck between attaining affordable prices for ultra-OMPs and securing a realistic return on investment for the pharmaceutical industry. Keywords: ultra-orphan medicinal product, ultra-rare disease, pricing

  3. Asthma, chronic obstructive pulmonary disease, or both? Diagnostic labeling and spirometry in primary care patients aged 40 years or more

    Directory of Open Access Journals (Sweden)

    Melbye H

    2011-11-01

    Full Text Available Hasse Melbye1, Elin Drivenes1, Lene G Dalbak2, Tone Leinan1, Svein Høegh-Henrichsen2, Anders Østrem21General Practice Research Unit, Department of Community Medicine, University of Tromsø, 2General Practice Research Unit, Department of Health and Society, University of Oslo, NorwayAims: To describe symptoms and lung function in patients registered with asthma or chronic obstructive pulmonary disease (COPD in primary care and to examine how spirometry findings fit with general practitioners’ (GPs diagnoses.Methods: Patients aged ≥40 years with a diagnosis of asthma or COPD registered in the electronic medical record during the previous 5 years were recruited at seven GP offices in Norway in 2009–2010. Registered diagnosis, spirometry results, comorbidity, and reported symptoms were compared.Results: Among 376 patients, 62% were women. Based on Global Initiative for Chronic Obstructive Lung Diseases criteria, a spirometry diagnosis of COPD could be made in 68.1% of the patients with a previous COPD diagnosis and in 17.1% of those diagnosed with asthma only (P < 0.001. The κ agreement between last clinical diagnosis of COPD and COPD based on spirometry was 0.50. A restrictive spirometry pattern was found in 19.4% and more frequently in patients diagnosed with both asthma and COPD (23.9% than in patients diagnosed with COPD only (6.8%, P = 0.003.Conclusion: The ability of GPs to differentiate between asthma and COPD seems to have considerably improved during the last decade, probably due to the dissemination of spirometry and guidelines for COPD diagnosis. A diagnosis of COPD that cannot be confirmed by spirometry represents a challenge in clinical practice, in particular when a restrictive pattern on spirometry is found.Keywords: asthma, COPD, diagnosis, primary care

  4. Negotiating a new day: parents' contributions to supporting students' school functioning after exposure to trauma

    Directory of Open Access Journals (Sweden)

    Grell

    2016-04-01

    Full Text Available Eline Grelland Røkholt,1 Jon-Håkon Schultz,2,3 Åse Langballe2 1Department of Allied Health, Bereavement Support Center, Akershus University Hospital, Lørenskog, 2Norwegian Center for Violence and Traumatic Stress Studies, Oslo, 3Department of Education, University of Tromsø, the Arctic University of Norway, Tromsø, Norway Abstract: Parents are advised to get their children back to school soon after exposure to trauma, so that they may receive social support and restore the supportive structure of everyday life. This study explores parents' experiences of supporting adolescents in regaining school functioning after the July 2011 massacre at Utøya summer camp in Norway. One year after the attack, 87 parents of 63 young people who survived the massacre were interviewed using qualitative interviews. The qualitative data were analyzed using thematic analysis. All parents were actively supportive of their children, and described a demanding process of establishing new routines to make school attendance possible. Most parents described radical changes in their adolescents. The struggle of establishing routines often brought conflict and frustration into the parent–adolescent relationship. Parents were given general advice, but reported being left alone to translate this into action. The first school year after the trauma was described as a frustrating and lonely struggle: their adolescents were largely unable to restore normal daily life and school functioning. In 20% of the cases, school–home relationships were strained and were reported as a burden because of poor understanding of needs and insufficient educational adaptive measures; a further 20% reported conflict in school–home relationships, while 50% were either positive or neutral. The last 10%, enrolled in apprenticeship, dropped out, or started working, instead of finishing school. Implications for supporting parents with traumatized adolescent students are indicated. Keywords

  5. Aus dem Land des roten Drachen

    Directory of Open Access Journals (Sweden)

    Thomas Krause

    2009-01-01

    Full Text Available Rezensierte Werke: Thomas Glyn Watkin, The Legal History of Wales, Cardiff: University of Wales Press 2007, X, 332 p., ISBN 978-0-7083-2064-8; Legal Wales: its Past, its Future. Essays dedicated to Professor Dafydd Jenkins on his ninetieth birthday, ed. by Thomas Glyn Watkin, Cardiff: Welsh Legal History Society 2001, XI, 181 p., ISBN 0-9541637-0-2; The Trial of Dic Penderyn and other Essays, ed. by Thomas Glyn Watkin, Cardiff: Welsh Legal History Society 2003, X, 196 p., ISBN 0-9541637-1-0; Y Cyfraniad Cymreig – Welsh Contributions to Legal Development, ed. by Thomas Glyn Watkin, Bangor: Welsh Legal History Society 2005, XI, 231 p., ISBN 0-9541637-2-9; Sir William Jones, An Essay of the Law of Bailments, 1781, ed. by David J. Ibbetson, Bangor: Welsh Legal History Society 2007, ISBN 0-9541637-3-7; Tair Colofn Cyfraith = The Three Columns of Law in Medieval Wales: Homicide, Theft and Fire, ed. by T.M. Charles-Edwards and Paul Russell, Bangor: Welsh Legal History Society 2007, ISBN 978-0-9541637-4-7; Sara Elin Roberts, The Legal Triads of Medieval Wales, Cardiff: University of Wales Press 2007, XV, 461 p., ISBN 978-0-7083-2107-2; Richard W. Ireland, A Want of Order…, Cardiff: University of Wales Press 2007, XIII, 302 p., ISBN 978-0-7083-1945-1; Sharon Howard, Law and Disorder in Early Modern Wales: Crime and Authority in the Denbighshire Courts, c. 1660–1730, Cardiff: University of Wales Press 2008, XXII, 295 p., ISBN 978-0-7083-1994-9

  6. Therapeutic elements in a self-management approach: experiences from group participation among people suffering from chronic pain

    Directory of Open Access Journals (Sweden)

    Furnes B

    2014-08-01

    Full Text Available Bodil Furnes,1 Gerd Karin Natvig,1,2 Elin Dysvik1 1Department of Health Studies, Faculty of Social Sciences, University of Stavanger, Stavanger, Norway; 2Department of Global Public Health and Primary Care, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway Objective: Chronic pain is a complex, multifaceted subjective experience that involves the whole person. Self-management is the dynamic and continuous process of adapting one’s situation to the cognitive, behavioral, and emotional responses necessary to maintain a satisfactory quality of life. Approaches based on cognitive behavioral therapy (CBT are described as appropriate in assisting people suffering from chronic pain because they challenge maladaptive beliefs and behaviors in relation to pain. This study aimed to explore patients’ experiences of therapeutic elements from group participation in a chronic pain management program. Methods: A qualitative research design with a phenomenological hermeneutic approach was used. Six months after participation in the 8-week course, 34 participants formulated and submitted written reports based on open-ended questions related to their group participation and self-help achievement. These reports were analyzed by elements of qualitative content analysis. Results: The analysis resulted in two subthemes: “The significance of active involvement in gaining new insight” and “The significance of community and group support.” These were abstracted in the main theme: “Successful self-management is related to several significant contributions in the group.” Conclusion: An active role with writing, self-revelation, and exchanges of thoughts and feelings in the group seemed to be the key tools for success. In addition, group support and access to other group members’ experiences were significant therapeutic elements. We suggest that successful self-management requires knowledge of essential therapeutic elements. In a CBT

  7. Miotonia congênita: relato de sete pacientes Congenital myotonia: report of seven patients

    Directory of Open Access Journals (Sweden)

    Helga C. A. Azevedo

    1996-12-01

    Full Text Available Miotonia é o fenômeno da diminuição da velocidade de relaxamento muscular após contração, estímulo mecânico ou elétrico. As miotonias congênitas são afecções hereditárias e não apresentam distrofia muscular. Atualmente, a tendência é agrupá-las como doenças de canais iônicos, juntamente com as paralisias periódicas. Foram acompanhados sete pacientes, seis do sexo masculino e um do sexo feminino, com idade entre 16 e 48 anos (média 27 anos e início dos sintomas entre 1 e 10 anos (média S anos, que apresentavam fenômeno miotônico desencadeado por contração intensa e hipertrofia muscular global. Três pacientes foram diagnosticados como miotonia generalizada tipo Becker por apresentarem herança autossômica recessiva e/ou episódios transitórios de fraqueza muscular. Dois pacientes correspondiam à miotonia congênita de Thomsen, com padrão de herança autossômica dominante e/ou ausência de episódios de fraqueza ou fatores de piora. Dois pacientes apresentavam miotonia flutuante, piorando com o frio e/ou ingestão de potássio. O diagnóstico clínico foi confirmado através de exames complementares (eletroneuromiografia, biópsia muscular e estudo do DNA. Cada paciente fez uso de diferentes drogas, no sentido de procurar o máximo de melhora da miotonia. Houve cinco relatos de melhora com difenil-hidantoína, um com carbamazepina, três com acetazolamida, um com bloqueador de canal de cálcio, um com beta-adrenérgico, um com tiazídico e nenhum com quinidina/procainamida.Myotonia is the phenomenon of decrease of muscular relaxation rate, after either a contraction or a mechanical or electrical stimulus. Congenital myotonias are hereditary affections and do not present muscular dystrophy. The current trend is to group them as ionic channels diseases, together with the periodic paralysis.The authors accompanied the cases of seven patients, six males and one female, with ages ranging from 16 to 48 years (average 27

  8. SCN4A variants and Brugada syndrome: phenotypic and genotypic overlap between cardiac and skeletal muscle sodium channelopathies.

    Science.gov (United States)

    Bissay, Véronique; Van Malderen, Sophie C H; Keymolen, Kathelijn; Lissens, Willy; Peeters, Uschi; Daneels, Dorien; Jansen, Anna C; Pappaert, Gudrun; Brugada, Pedro; De Keyser, Jacques; Van Dooren, Sonia

    2016-03-01

    SCN5A mutations involving the α-subunit of the cardiac voltage-gated muscle sodium channel (NaV1.5) result in different cardiac channelopathies with an autosomal-dominant inheritance such as Brugada syndrome. On the other hand, mutations in SCN4A encoding the α-subunit of the skeletal voltage-gated sodium channel (NaV1.4) cause non-dystrophic myotonia and/or periodic paralysis. In this study, we investigated whether cardiac arrhythmias or channelopathies such as Brugada syndrome can be part of the clinical phenotype associated with SCN4A variants and whether patients with Brugada syndrome present with non-dystrophic myotonia or periodic paralysis and related gene mutations. We therefore screened seven families with different SCN4A variants and non-dystrophic myotonia phenotypes for Brugada syndrome and performed a neurological, neurophysiological and genetic work-up in 107 Brugada families. In the families with an SCN4A-associated non-dystrophic myotonia, three patients had a clinical diagnosis of Brugada syndrome, whereas we found a remarkably high prevalence of myotonic features involving different genes in the families with Brugada syndrome. One Brugada family carried an SCN4A variant that is predicted to probably affect function, one family suffered from a not genetically confirmed non-dystrophic myotonia, one family was diagnosed with myotonic dystrophy (DMPK gene) and one family had a Thomsen disease myotonia congenita (CLCN1 variant that affects function). Our findings and data suggest a possible involvement of SCN4A variants in the pathophysiological mechanism underlying the development of a spontaneous or drug-induced type 1 electrocardiographic pattern and the occurrence of malignant arrhythmias in some patients with Brugada syndrome.

  9. A new parameterization for waveform inversion in acoustic orthorhombic media

    KAUST Repository

    Masmoudi, Nabil

    2016-05-26

    Orthorhombic anisotropic model inversion is extra challenging because of the multiple parameter nature of the inversion problem. The high number of parameters required to describe the medium exerts considerable trade-off and additional nonlinearity to a full-waveform inversion (FWI) application. Choosing a suitable set of parameters to describe the model and designing an effective inversion strategy can help in mitigating this problem. Using the Born approximation, which is the central ingredient of the FWI update process, we have derived radiation patterns for the different acoustic orthorhombic parameterizations. Analyzing the angular dependence of scattering (radiation patterns) of the parameters of different parameterizations starting with the often used Thomsen-Tsvankin parameterization, we have assessed the potential trade-off between the parameters and the resolution in describing the data and inverting for the parameters. The analysis led us to introduce new parameters ϵd, δd, and ηd, which have azimuthally dependent radiation patterns, but keep the scattering potential of the transversely isotropic parameters stationary with azimuth (azimuth independent). The novel parameters ϵd, δd, and ηd are dimensionless and represent a measure of deviation between the vertical planes in orthorhombic anisotropy. Therefore, these deviation parameters offer a new parameterization style for an acoustic orthorhombic medium described by six parameters: three vertical transversely isotropic (VTI) parameters, two deviation parameters, and one parameter describing the anisotropy in the horizontal symmetry plane. The main feature of any parameterization based on the deviation parameters, is the azimuthal independency of the modeled data with respect to the VTI parameters, which allowed us to propose practical inversion strategies based on our experience with the VTI parameters. This feature of the new parameterization style holds for even the long-wavelength components of

  10. Compulsive exercise: links, risks and challenges faced

    Directory of Open Access Journals (Sweden)

    Lichtenstein MB

    2017-03-01

    Full Text Available Mia Beck Lichtenstein,1 Cecilie Juul Hinze,2 Bolette Emborg,3 Freja Thomsen,2 Simone Daugaard Hemmingsen4 1Department of Psychology, Faculty of Health Sciences, University of Southern Denmark, 2Research Unit for Telepsychiatry and E-mental Health, Mental Health Services in the Region of Southern Denmark, Odense, 3Department of Public Health, Aarhus University, Aarhus, 4Research Unit, Child and Adolescent Psychiatry, Mental Health Services in the Region of Southern Denmark, Odense, Denmark Abstract: Compulsive exercise is a condition described since 1970s. It is characterized by a craving for physical training, resulting in uncontrollable excessive exercise behavior with harmful consequences, such as injuries and impaired social relations. It has not been accepted as a mental disorder in either International Classification of Diseases or Diagnostic and Statistical Manual of Mental Disorders. The aim of this literature review was to critically examine the research on links (comorbidity, risks (negative consequences, and challenges faced (problems in a treatment context. This review found that compulsive exercise is associated with eating disorder pathology, perfectionism, neuroticism, narcissism, and obsessive compulsive traits. The most prominent negative consequences were injuries, social impairment, and depression, but more research is needed to uncover the potential dysfunction resulting from compulsive exercise. As the condition is not recognized as a psychiatric disorder, studies on treatment interventions are sparse. Problems with compliance have been reported; therefore, motivational interviewing has been proposed as a treatment approach, in combination with cognitive behavioral therapy. This review summarizes and discusses findings on links/comorbidity, risks/negative consequences, and treatment challenges. We suggest that future studies should pay attention to both prevention and counseling in sports settings, where compulsive exercise

  11. Does marriage protect against hospitalization with pneumonia? A population-based case-control study

    Directory of Open Access Journals (Sweden)

    Mor A

    2013-10-01

    Full Text Available Anil Mor, Sinna P Ulrichsen, Elisabeth Svensson, Klara Berencsi, Reimar W Thomsen Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark Background: To reduce the increasing burden of pneumonia hospitalizations, we need to understand their determinants. Being married may decrease the risk of severe infections, due to better social support and healthier lifestyle. Patients and methods: In this population-based case-control study, we identified all adult patients with a first-time pneumonia-related hospitalization between 1994 and 2008 in Northern Denmark. For each case, ten sex- and age-matched population controls were selected from Denmark's Civil Registration System. We performed conditional logistic regression analysis to estimate the odds ratios (ORs for pneumonia hospitalization among persons who were divorced, widowed, or never married, as compared with married persons, adjusting for age, sex, 19 different comorbidities, alcoholism-related conditions, immunosuppressant use, urbanization, and living with small children. Results: The study included 67,162 patients with a pneumonia-related hospitalization and 671,620 matched population controls. Compared with controls, the pneumonia patients were more likely to be divorced (10% versus 7% or never married (13% versus 11%. Divorced and never-married patients were much more likely to have previous diagnoses of alcoholism-related conditions (18% and 11%, respectively compared with married (3% and widowed (6% patients. The adjusted OR for pneumonia-related hospitalization was increased, at 1.29 (95% confidence interval [CI]: 1.25-1.33 among divorced; 1.15 (95% CI: 1.12-1.17 among widowed; and 1.33 (95% CI: 1.29-1.37 among never-married individuals as compared with those who were married. Conclusion: Married individuals have a decreased risk of being hospitalized with pneumonia compared with never-married, divorced, and widowed patients

  12. Identification of a single-nucleotide insertion in the promoter region affecting the sodC promoter activity in Brucella neotomae.

    Directory of Open Access Journals (Sweden)

    Dina A Moustafa

    Full Text Available Brucella neotomae is not known to be associated with clinical disease in any host species. Previous research suggested that B. neotomae might not express detectable levels of Cu/Zn superoxide dismutase (SOD, a periplasmic enzyme known to be involved in protecting Brucella from oxidative bactericidal effects of host phagocytes. This study was undertaken to investigate the genetic basis for the disparity in SOD expression in B. neotomae. Our Western blot and SOD enzyme assay analyses indicated that B. neotomae does express SOD, but at a substantially reduced level. Nucleotide sequence analysis of region upstream to the sodC gene identified a single-nucleotide insertion in the potential promoter region. The same single-nucleotide insertion was also detected in the sodC promoter of B. suis strain Thomsen, belonging to biovar 2 in which SOD expression was undetectable previously. Examination of the sodC promoter activities using translational fusion constructs with E. coli β-galactosidase demonstrated that the B. neotomae and B. suis biovar 2 promoters were very weak in driving gene expression. Site-directed mutation studies indicated that the insertion of A in the B. neotomae sodC promoter reduced the promoter activity. Increasing the level of SOD expression in B. neotomae through complementation with B. abortus sodC gene did not alter the bacterial survival in J774A.1 macrophage-like cells and in tissues of BALB/c and C57BL/6 mice. These results for the first time demonstrate the occurrence of a single-nucleotide polymorphism affecting promoter function and gene expression in Brucella.

  13. Second world renewable energy assembly (WREA) 2007; 2. Weltversammlung fuer Erneuerbare Energien (WREA) 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    Within the Second World Renewable Energy Assembly at 19th to 21st November, 2007, in Bonn (Federal Republic of Germany), the following lectures were held: (1) How to motivate common people, scientists, companies and policy makers for renewable energy (Volker Thomsen); (2) Renewables 2007 Global Status Report (Eric Martinot); (3) Renewable Energy in Africa (Ibrahim Togola); (4) Legislation, the great challenge for renewable energies in Latin America (Mauro Passos); (5) Building Strategic North American Alliances to Maximize the Implementation of Renewable Energy (Jose Etcheverry); (6) Renewable Energy and Sustainable Development (Shi DingHuan); (7) Renewable Energies in EU27 (Wolfgang Palz); (8) The health costs of conventional energies (Susanne Weber-Mosdorf); (9) The need for a EU-wide Moratorium on Incentives for Agrofuels and Imports of Agrofuels (Sergio Oceransky); (10) The nuclear power is no solution (Eike Schwarz); (11) Carbon Trading - a critical conversation on climate change, privatisation and power (Jutta Kil); (12) The culminating energy insecurity (Joerg Schindler); (13) 100 % Renewables Scenarios an Overview (Harry Lehmann); (14) ICLEI's Local Renewables Initiative What local governments can do to promote the generation and use of renewable energy (Monika Zimmermann); (15) 100 % Projects for cities, countries and regions - an overview (Michael Stoehr); (16) Conceptualizing RE Strategies (Heinz-Wolfgang Boehnke); (17) Negawatts and Micropower: The Coming Electrical Revolution (Amory Lovins); (18) Renewable Energies, Sustainability and World Trade - Overcoming the double standard (Doerte Fouquet); (19) Financing strategies for Renewable Energies in Latin America and The Caribbean (Pablo Rosenthal); (20) Overcoming the Double-Standards: Subsidies for Nuclear and Fossil Energy (Doug Koplow); (21) The prepossession of international institutions for energy (Hans-Josef Fell); (22) The bias of the international energy institutions: The case of IAEO

  14. Correlations between measures of executive attention and cortical thickness of left posterior middle frontal gyrus - a dichotic listening study

    Directory of Open Access Journals (Sweden)

    Lundervold Arvid

    2009-10-01

    Full Text Available Abstract Background The frontal lobe has been associated to a wide range of cognitive control functions and is also vulnerable to degeneration in old age. A recent study by Thomsen and colleagues showed a difference between a young and old sample in grey matter density and activation in the left middle frontal cortex (MFC and performance on a dichotic listening task. The present study investigated this brain behaviour association within a sample of healthy older individuals, and predicted a positive correlation between performance in a condition requiring executive attention and measures of grey matter structure of the posterior left MFC. Methods A dichotic listening forced attention paradigm was used to measure attention control functions. Subjects were instructed to report only the left or the right ear syllable of a dichotically presented consonant-vowel syllable pair. A conflict situation appears when subjects are instructed to report the left ear stimulus, caused by the conflict with the bottom-up, stimulus-driven right ear advantage. Overcoming this processing conflict was used as a measure of executive attention. Thickness and volumes of frontal lobe regions were derived from automated segmentation of 3D magnetic resonance image acquisitions. Results The results revealed a statistically significant positive correlation between the thickness measure of the left posterior MFC and performance on the dichotic listening measures of executive attention. Follow-up analyses showed that this correlation was only statistically significant in the subgroup that showed the typical bottom-up, stimulus-driven right ear advantage. Conclusion The results suggest that the left MFC is a part of an executive attention network, and that the dichotic listening forced attention paradigm may be a feasible tool for assessing subtle attentional dysfunctions in older adults.

  15. Traveltime approximations and parameter estimation for orthorhombic media

    KAUST Repository

    Masmoudi, Nabil

    2016-05-30

    Building anisotropy models is necessary for seismic modeling and imaging. However, anisotropy estimation is challenging due to the trade-off between inhomogeneity and anisotropy. Luckily, we can estimate the anisotropy parameters Building anisotropy models is necessary for seismic modeling and imaging. However, anisotropy estimation is challenging due to the trade-off between inhomogeneity and anisotropy. Luckily, we can estimate the anisotropy parameters if we relate them analytically to traveltimes. Using perturbation theory, we have developed traveltime approximations for orthorhombic media as explicit functions of the anellipticity parameters η1, η2, and Δχ in inhomogeneous background media. The parameter Δχ is related to Tsvankin-Thomsen notation and ensures easier computation of traveltimes in the background model. Specifically, our expansion assumes an inhomogeneous ellipsoidal anisotropic background model, which can be obtained from well information and stacking velocity analysis. We have used the Shanks transform to enhance the accuracy of the formulas. A homogeneous medium simplification of the traveltime expansion provided a nonhyperbolic moveout description of the traveltime that was more accurate than other derived approximations. Moreover, the formulation provides a computationally efficient tool to solve the eikonal equation of an orthorhombic medium, without any constraints on the background model complexity. Although, the expansion is based on the factorized representation of the perturbation parameters, smooth variations of these parameters (represented as effective values) provides reasonable results. Thus, this formulation provides a mechanism to estimate the three effective parameters η1, η2, and Δχ. We have derived Dix-type formulas for orthorhombic medium to convert the effective parameters to their interval values.

  16. The Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) NASA Mission-of- Opportunity - Up and Operational

    Science.gov (United States)

    McComas, D. J.

    2008-12-01

    *Presented on behalf of the entire TWINS Team Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) is a NASA Explorer Mission-of-Opportunity to stereoscopically image the Earth's magnetosphere for the first time [McComas et al., 2008]. TWINS extends our understanding of magnetospheric structure and processes by providing simultaneous Energetic Neutral Atom (ENA) imaging from two widely separated locations. TWINS observes ENAs from 1-100 keV with high angular (~4° x 4°) and time (~1-minute) resolution. The TWINS Ly-α monitor measures the geocoronal hydrogen density to aid in ENA analysis while environmental sensors provide contemporaneous measurements of the local charged particle environments. By imaging ENAs with identical instruments from two widely spaced, high-altitude, high-inclination spacecraft, TWINS enables three-dimensional visualization of the large-scale structures and dynamics within the magnetosphere for the first time. As of the summer of 2008, both TWINS instruments are finally on orbit and operational and stereo imaging of the magnetosphere has begun. This talk briefly summarizes the TWINS mission and instruments and shows some of the 'first-light' observations. More information about TWINS and access to these data are available at http://twins.swri.edu. Reference: McComas, D.J., F. Allegrini, J. Baldonado, B. Blake, P. C. Brandt, J. Burch, J. Clemmons, W. Crain, D. Delapp, R. DeMajistre, D. Everett, H. Fahr, L. Friesen, H. Funsten, J. Goldstein, M. Gruntman, R. Harbaugh, R. Harper, H. Henkel, C. Holmlund, G. Lay, D. Mabry, D. Mitchell, U. Nass, C. Pollock, S. Pope, M. Reno, S. Ritzau, E. Roelof, E. Scime, M. Sivjee, R. Skoug, T. S. Sotirelis, M. Thomsen, C. Urdiales, P. Valek, K. Viherkanto, S. Weidner, T. Ylikorpi, M. Young, J. Zoennchen, The Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) NASA Mission-of-Opportunity, Submitted to Space Science Reviews, 2008.

  17. Circulating tumor cells in patients with metastatic castration resistant prostate cancer: exploratory findings at a tertiary referral hospital

    Directory of Open Access Journals (Sweden)

    Fosså SD

    2014-09-01

    Full Text Available Sophie D Fosså,1 Siri L Hess,1 Elisabeth Paus,2 Elin Borgen3 1National Resource Center for Late Effects after Cancer Treatment, 2Department of Medical Biochemistry, 3Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Radiumhospital, Oslo, Norway Objectives: In patients with metastatic castration-resistant prostate cancer (mCRPC, the finding of less than five circulating tumor cells (CTCs/7.5 mL blood before start of cytotoxic treatment or shortly thereafter indicates prolonged survival. In this descriptive pilot study, we investigated whether this association depends on the sequence of the therapeutic attempts. Patients and methods: CTCs were determined in 41 mCRPC patients before and 2–3 months after starting first-line treatment with docetaxel (group 1 or second-line treatment with either radium-223 (group 2 or placebo/best supportive care (group 3. A "favorable" CTC count was defined as <5 CTC/7.5 mL blood. The results were related to overall survival. Results: Pretreatment, six of ten men in group 1, three of 19 in group 2, and three of 12 patients in group 3 had a favorable CTC count, leading to a significant difference between first- and second-line therapy (P=0.04. Decrease of pretreatment elevated CTCs to a favorable CTC count was significantly more often observed in patients on first-line therapy (three of four patients than on second-line treatment (two of 26 men (P=0.03. A favorable CTC count before or shortly after treatment start was observed in nine of ten patients on first-line and in eight of 31 men on second-line therapy (P=0.01. A favorable CTC count pretreatment or 2–3 months after therapy start was associated with beneficial overall survival in the three groups combined and in each group analyzed separately. Conclusion: In mCRPC, a favorable CTC count before or 2–3 months after start of therapy is associated with length of overall survival, though such favorable CTC counts are observed

  18. The Virtual Care Climate Questionnaire: Development and Validation of a Questionnaire Measuring Perceived Support for Autonomy in a Virtual Care Setting.

    Science.gov (United States)

    Smit, Eline Suzanne; Dima, Alexandra Lelia; Immerzeel, Stephanie Annette Maria; van den Putte, Bas; Williams, Geoffrey Colin

    2017-05-08

    to be reasonably valid and reliable. As a result, the current version may cautiously be used in future research and practice to measure perceived support for autonomy within a virtual care climate. Future research efforts are required that focus on further investigating the virtual climate care questionnaire's divergent validity, on determining the virtual climate care questionnaire's validity and reliability when used in the context of Web-based interventions aimed at improving nonaddictive or other health behaviors, and on developing and validating a short form virtual climate care questionnaire. ©Eline Suzanne Smit, Alexandra Lelia Dima, Stephanie Annette Maria Immerzeel, Bas van den Putte, Geoffrey Colin Williams. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 08.05.2017.

  19. Self-Management and Self-Efficacy in Patients With Acute Spinal Cord Injuries: Protocol for a Longitudinal Cohort Study.

    Science.gov (United States)

    van Diemen, Tijn; Scholten, Eline Wm; van Nes, Ilse Jw; Geertzen, Jan Hb; Post, Marcel Wm

    2018-02-26

    People with recently acquired spinal cord injury (SCI) experience changes in physical, social and psychological aspects of their lives. In the last decades, attention has grown for aspects of self-management and self-efficacy in SCI research. However, we still do not know what the self-management and self-efficacy outcomes of first rehabilitation are and whether utilizing these skills may prevent secondary health conditions (SHCs) and increase participation and psychological adjustment early after SCI. To describe the course and determinants of self-management and self-efficacy during and after first SCI rehabilitation; and to determine theory-based associations between self-management and self-efficacy with SHCs, participation and psychological adjustment. Multicenter prospective longitudinal cohort study. All people with a newly acquired SCI admitted to one of the 8 specialized SCI rehabilitation centers in the Netherlands will be considered for inclusion in this study. Main assessments will take place during the first and last week of admission and 3, 6 and 12 months after discharge. The target sample is 250 participants. The primary outcomes are self-management (knowledge and execution of self-care) and self-efficacy (confidence in the ability to manage the consequences of SCI and of self-care). Secondary outcome measures are SHCs, participation and psychological adjustment to SCI. The first results with the complete set of data are expected in June 2019. This protocol describes the SELF-SCI cohort study investigating self-management and self-efficacy of initial inpatient SCI rehabilitation. Second, associations will be investigated with SHCs, participation and psychological adjustment early after onset of SCI, until 1 year after discharge. The results will be used to test theories about motivation to perform health-promoting behaviors and adjustment to SCI. ©Tijn van Diemen, Eline WM Scholten, Ilse JW van Nes, SELF-SCI Group, Jan HB Geertzen, Marcel WM Post

  20. The Jurassic of Denmark and Greenland: Middle Jurassic – Early Cretaceous rifting of the Danish Central Graben

    Directory of Open Access Journals (Sweden)

    Møller, Jens J.

    2003-10-01

    Full Text Available During the Jurassic - Early Cretaceous, the Danish Central Graben developed as a N-S- to NNW- SSE-trending graben bounded by the Ringkøbing-Fyn High towards the east and the Mid North Sea High towards the west. The graben consists of a system of half-grabens and evolved by faultcontrolled subsidence; three main rift pulses have been recognised. The first pulse ranged from the Callovian to the Early Oxfordian, the second pulse was initiated in the latest Late Kimmeridgian and lasted for most of the Early Volgian, and the third and final pulse occurred within the Ryazanian in the Early Cretaceous. The first pulse was characterised by subsidence along N-S-trending faults. The most pronounced fault-controlled subsidence occurred in the east, especially along N-S-striking segments of the boundary fault to the Ringkøbing-Fyn High. During this period, minor salt movements occurred with the development of salt pillows. The activity along the N-S-trending faults ceased during the Oxfordian. During the second pulse, in Early Volgian times, subsidence was concentrated along new NNW-SSE-trending faults and the main depocentre shifted westward, being most marked within the Tail End Graben, the Arne-Elin Graben, and the Feda Graben. This tectonic event was accompanied by the accumulation of a relatively thick sediment load resulting in the development of salt diapirs, especially within the Salt Dome Province. The third tectonic pulse was essentially a reactivation of the NNW-SSE-trending structures and there is clear evidence of subsidence controlled by faulting and salt movements. Despite the overall extensional tectonic regime, local compressional tectonics resulted in thrusting. For instance, the Gert Ridge is interpreted to have formed by readjustment at the boundary fault between two subsiding blocks. The structural framework during graben evolution controlled, to some degree, the distribution of reservoir sandstones. Reservoir sandstones associated

  1. Examining Environmental Gradients with Remotely Sensed Data - the ESA GlobPermafrost project

    Science.gov (United States)

    Bartsch, Annett; Grosse, Guido; Kääb, Andreas; Westermann, Sebastian; Strozzi, Tazio; Wiesmann, Andreas; Duguay, Claude; Seifert, Frank Martin; Obu, Jaroslav; Nitze, Ingmar; Heim, Birgit; Haas, Antoni; Widhalm, Barbara

    2017-04-01

    , Claude R; Grosse, Guido; Günther, Frank; Heim, Birgit; Högström, Elin; Kääb, Andreas; Keuper, Frida; Lanckman, Jean-Pierre; Lantuit, Hugues; Lauknes, Tom Rune; Leibman, Marina O; Liu, Lin; Morgenstern, Anne; Necsoiu, Marius; Overduin, Pier Paul; Pope, Allen; Sachs, Torsten; Séjourné, Antoine; Streletskiy, Dmitry A; Strozzi, Tazio; Ullmann, Tobias; Ullrich, Matthias S; Vieira, Goncalo; Widhalm, Barbara (2014): Requirements for monitoring of permafrost in polar regions - A community white paper in response to the WMO Polar Space Task Group (PSTG), Version 4, 2014-10-09. Austrian Polar Research Institute, Vienna, Austria, 20 pp, hdl:10013/epic.45648.d001

  2. Older patients' experiences during care transition

    Directory of Open Access Journals (Sweden)

    Rustad EC

    2016-05-01

    Full Text Available Else Cathrine Rustad,1–4 Bodil Furnes,1 Berit Seiger Cronfalk,2,5,6 Elin Dysvik1 1Department of Health Studies, Faculty of Social Sciences, University of Stavanger, Stavanger, Norway; 2Faculty of Health and Caring Sciences, Stord Haugesund University College, Stord, Norway; 3Research Network on Integrated Health Care in Western Norway, Helse Fonna Local Health Authority, Haugesund, Norway; 4Department of Clinical Medicine, Helse Fonna Local Health Authority, Haugesund, Norway; 5Palliative Research Center, Ersta Sköndal University College, Stockholm, Sweden; 6Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden Background: A fragmented health care system leads to an increased demand for continuity of care across health care levels. Research indicates age-related differences during care transition, with the oldest patients having experiences and needs that differ from those of other patients. To meet the older patients’ needs and preferences during care transition, professionals must understand their experiences.Objective: The purpose of the study was to explore how patients ≥80 years of age experienced the care transition from hospital to municipal health care services.Methods: The study has a descriptive, explorative design, using semistructured interviews. Fourteen patients aged ≥80 participated in the study. Qualitative content analysis was used to describe the individuals’ experiences during care transition.Results: Two complementary themes emerged during the analysis: “Participation depends on being invited to plan the care transition” and “Managing continuity of care represents a complex and challenging process”.Discussion: Lack of participation, insufficient information, and vague responsibilities among staff during care transition seemed to limit the continuity of care. The patients are the vulnerable part of the care transition process, although they possess important

  3. The 12-item Self-Report World Health Organization Disability Assessment Schedule (WHODAS) 2.0 Administered Via the Internet to Individuals With Anxiety and Stress Disorders: A Psychometric Investigation Based on Data From Two Clinical Trials.

    Science.gov (United States)

    Axelsson, Erland; Lindsäter, Elin; Ljótsson, Brjánn; Andersson, Erik; Hedman-Lagerlöf, Erik

    2017-12-08

    subfactors to facilitate comparisons between studies. Clinicaltrials.gov NCT02540317; https://clinicaltrials.gov/ct2/show/NCT02540317 (Archived by WebCite at http://www.webcitation.org/6vQEdYAem); Clinicaltrials.gov NCT02314065; https://clinicaltrials.gov/ct2/show/NCT02314065 (Archived by WebCite at http://www.webcitation.org/6vQEjlUU8). ©Erland Axelsson, Elin Lindsäter, Brjánn Ljótsson, Erik Andersson, Erik Hedman-Lagerlöf. Originally published in JMIR Mental Health (http://mental.jmir.org), 08.12.2017.

  4. NASA's Earth Observations of the Global Environment: Our Changing Planet and the View from Space

    Science.gov (United States)

    King, michael D.

    2005-01-01

    A birds eye view of the Earth from afar and up close reveals the power and magnificence of the Earth and juxtaposes the simultaneous impacts and powerlessness of humankind. The NASA Electronic Theater presents Earth science observations and visualizations in an historical perspective. See the latest spectacular images from NASA remote sensing missions like TRMM, SeaWiFS, Landsat 7, Terra, and Aqua, which will be visualized and explained in the context of global change and man s impact on our world s environment. See visualizations of global data sets currently available from Earth orbiting satellites, including the Earth at night with its city lights. Shown in high resolution are visualizations of tropical cyclone Eline and the resulting flooding of Mozambique. See flybys of Cape Town, South Africa with its dramatic mountains and landscape, as well as satellite imagery of fires that occurred globally, with a special emphasis on fires in the western US during summer 2001, and how new satellite tools can be used to help fight these disasters from spreading further. See where and when lightning occurs globally, and how dramatic urbanization has been in the desert southwest since 1910. Spectacular visualizations of the global atmosphere and oceans are shown. Learn when and where carbon is absorbed by vegetation on the land and ocean as the product of photosynthesis. See demonstrations of the 3-dimensional structure of hurricanes and cloud structures derived from recently launched Earth-orbiting satellites, and how hurricanes can modify the sea surface temperature in their wake. See massive dust storms in the Middle East as well as dust transport sweeping from north Africa across the Atlantic to the Caribbean and Amazon basin. Learn where and how much the temperature of the Earth s surface has changed during the 20th century, as well as how sea ice has decreased over the Arctic region, how sea level has and is likely to continue to change, and how glaciers have

  5. The Synthesis of N-Acetyllactosamine Functionalized Dendrimers, and the Functionalization of Silica Surfaces Using Tunable Dendrons and beta-Cyclodextrins

    Science.gov (United States)

    Ennist, Jessica Helen

    Galectin-3 is beta-galactoside binding protein which is found in many healthy cells. In cancer, the galectin-3/tumor-associated Thomsen-Friedenreich antigen (TF antigen) interaction has been implicated in heterotypic and homotypic cellular adhesion and apoptotic signaling pathways. However, a stronger mechanistic understanding of the role of galectin-3 in these processes is needed. N-acetyllactosamine (LacNAc) is a non-native ligand for galectin-3 which binds with comparable affinity to the TF antigen and therefore an important ligand to study galectin-3 mediated processes. To study galectin-3 mediated homotypic cellular aggregation, four generations of polyamidoamine (PAMAM) dendrimers were functionalized with N-acetyllactosamine using a four-step chemoenzymatic route. The enzymatic step controlled the regiochemistry of the galactose addition to N-acetylglucosamine functionalized dendrimers using a recombinant beta-1,4-Galactosyltransferase-/UDP-4'-Gal Epimerase Fusion Protein (lgtB-galE). Homotypic cellular aggregation, which is promoted by the presence of galectin-3 as it binds to glycosides at the cell surface, was studied using HT-1080 fibrosarcoma, A549 lung, and DU-145 prostate cancer cell lines. In the presence of small LacNAc functionalized PAMAM dendrimers, galectin-3 induced cancer cellular aggregation was inhibited. However, the larger glycodendrimers induced homotypic cellular aggregation. Additionally, novel poly(aryl ether) dendronized silica surfaces designed for reversible adsorbtion of targeted analytes were synthesized, and characterization using X-ray Photoelectron Spectroscopy (XPS) was performed. Using a Cu(I) mediated cycloaddition "click" reaction, beta-cyclodextrin was appended to dendronized surfaces via triazole formation and also to a non-dendronized surface for comparison purposes. First generation G(1) dendrons have more than 6 times greater capacity to adsorb targeted analytes than slides functionalized with monomeric beta

  6. Defining carbohydrate specificity of Ricinus communis agglutinin as Gal beta 1-->4GlcNAc (II) > Gal beta 1-->3GlcNAc (I) > Gal alpha 1-->3Gal (B) > Gal beta 1-->3GalNAc (T).

    Science.gov (United States)

    Wu, J H; Herp, A; Wu, A M

    1993-03-01

    To define carbohydrate specificity of Ricinus communis agglutinin (RCA1), the combining site of RCA1 was further characterized by quantitative precipitin (QPA) and precipitin-inhibition assays (QPIA). Among the oligosaccharides tested for QPIA, Gal beta 1-->4GlcNAc (II, human blood group type II precursor sequence) was found to be 7.1 times more active than Gal beta 1-->3GalNAc (T, Thomsen-Friedenreich sequence) and about 1.7 times more active than the other three disaccharides tested--Gal beta 1-->4Man, Gal beta 1-->3DAra and Gal beta 1-->6GalNAc. Gal alpha 1-->4Gal, the receptor of the uropathogenic E. coli ligand was 3.6 times less active than the II sequence. These results indicate that the beta 1-->4 linkage of the terminal Gal to subterminal GlcNAc is important as this beta 1-->4GlcNAc sequence is at least 1.6 times more active than other types of disaccharides. Among the glycoproteins examined for QPA, native and desialized bovine submandibular glycoproteins, native and desialized human plasma alpha 1-acid glycoproteins, as well as crude hog stomach mucin and its three mild acid hydrolyzed products reacted well with the lectin. These glycoproteins precipitated over 75% of the lectin nitrogen added indicating that RCA1 has the ability to recognize Gal beta 1-->4/3GlcNAc and/or the related residues at the non-reducing ends and at positions in the interior of the chains. However, Tn (GalNAc alpha 1-->Ser/Thr sequence) rich glycoproteins such as desialized ovine submandibular glycoprotein and desialized armadillo salivary glycoprotein, in which over 90% of the carbohydrate side chains are Tn determinants with none or only a trace of I/II or T determinants, precipitated poorly with RCA1. From the present and previous results obtained, the carbohydrate specificity of RCA1 can be constructed and summarized in decreasing order by lectin determinants as follows: II (Gal beta 1-->4GlcNAc) > I (Gal beta 1-->3GlcNAc) > E (Gal alpha 1-->4Gal) and B (Gal alpha 1-->3Gal

  7. Role of nanostructured gold surfaces on monocyte activation and Staphylococcus epidermidis biofilm formation

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    Svensson S

    2014-02-01

    Full Text Available Sara Svensson,1,2 Magnus Forsberg,1,2 Mats Hulander,1,2 Forugh Vazirisani,1,2 Anders Palmquist,1,2 Jukka Lausmaa,2,3 Peter Thomsen,1,2 Margarita Trobos1,21Department of Biomaterials, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; 2BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden; 3SP Technical Research Institute of Sweden, Borås, SwedenAbstract: The role of material surface properties in the direct interaction with bacteria and the indirect route via host defense cells is not fully understood. Recently, it was suggested that nanostructured implant surfaces possess antimicrobial properties. In the current study, the adhesion and biofilm formation of Staphylococcus epidermidis and human monocyte adhesion and activation were studied separately and in coculture in different in vitro models using smooth gold and well-defined nanostructured gold surfaces. Two polystyrene surfaces were used as controls in the monocyte experiments. Fluorescent viability staining demonstrated a reduction in the viability of S. epidermidis close to the nanostructured gold surface, whereas the smooth gold correlated with more live biofilm. The results were supported by scanning electron microscopy observations, showing higher biofilm tower formations and more mature biofilms on smooth gold compared with nanostructured gold. Unstimulated monocytes on the different substrates demonstrated low activation, reduced gene expression of pro- and anti-inflammatory cytokines, and low cytokine secretion. In contrast, stimulation with opsonized zymosan or opsonized live S. epidermidis for 1 hour significantly increased the production of reactive oxygen species, the gene expression of tumor necrosis factor-α (TNF-α, interleukin-1β (IL-1β, IL-6, and IL-10, as well as the secretion of TNF-α, demonstrating the ability of the cells to elicit a response and actively phagocytose prey. In addition, cells cultured on the smooth

  8. ELVIS: Multi-Electrolyte Aqueous Activity Model for Geothermal Solutions

    Science.gov (United States)

    Hingerl, F. F.; Wagner, T.; Driesner, T.; Kulik, D. A.; Kosakowski, G.

    2011-12-01

    pressure, temperature, and composition. The new model, called ELVIS, combines an electrostatic framework developed by Helgeson and coworkers [1] with non- electrostatic concepts derived from the EUNIQUAC model [2]. ELVIS has significantly less fitting parameters than the Pitzer approach, but is sufficiently accurate in predicting mineral solubility within experimental error. Results of first parameterizations of ELVIS to geothermal solutions (dilute to concentrated brines from ambient conditions to ~300°C and ~800bars) will be presented. [1] Helgeson, H. H., Kirkham, D. H., Flowers, G. C. (1981), Am. J. Sc. 281, 1249-1516. [2] Thomsen, K., Rasmussen, P., Gani, R. (1996), Chem. Eng. Sc. 51, 3675-3683.

  9. Ultrasonic Seismic Wave Elastic Moduli and Attenuation, Petro physical Models and Work Flows for Better Subsurface Imaging Related to Monitoring of Sequestrated Supercritical CO2 and Geothermal Energy Exploration

    Science.gov (United States)

    Harbert, W.; Delaney, D.; Mur, A. J.; Purcell, C.; Zorn, E.; Soong, Y.; Crandall, D.; Haljasmaa, I.

    2016-12-01

    present approaches to incorporate these laboratory results into well log calibrated MATLAB based Gassmann-Biot fluid substitution models incorporating compliant porosity, Thomsen parameters models that utilize orthorhombic velocity anisotropy to predict seismic responses.

  10. Seismic velocity anisotropy of phyllosilicate-rich rocks: characteristics inferred from experimental and crack-model studies of biotite-rich schist

    Science.gov (United States)

    Nishizawa, O.; Kanagawa, K.

    2010-07-01

    's extended Thomsen approach.

  11. In situ seismic anisotropy around deep earthquakes in Japan subduction slabs using Japan Meteorological Agency moment tensors

    Science.gov (United States)

    Li, J.; Zheng, Y.; Thomsen, L.

    2017-12-01

    Knowing the in situ seismic anisotropy around deep earthquakes in slabs is important in understanding deep-earthquake mechanism as it may provide critically needed information about the rock fabric where deep earthquakes occur. It has been recognized for about 50 years that many deep earthquakes are not double-couple (DC) events. Previously we showed that in situ anisotropy around deep earthquakes could explain such observed non-DC events. Traditionally, the shear wave splitting method has been used to infer such anisotropy around deep earthquakes but this is challenging because it will need many crossing ray paths for the method to localize the anisotropic region (Long 2013). In this abstract, we adopt the same procedure to obtain anisotropy in the Pacific slab under Japan using moment tensors provided by the Japan Meteorological Agency using the F-net data. We directly probe the in situ anisotropy within the subducting slabs using the radiation patterns (represented by the moment tensors) of deep earthquakes (with depth greater than 60 km). By assuming a group of shear dislocation events embedded in a common tilted transversely isotropic (TTI) medium, we used the moment tensors as our input data to invert for the anisotropy in Mariana-Japan-Kuril subducting zone. The TTI medium is characterized by the P and S wave velocities along the symmetry axis (described by two free angles) and three Thomsen parameters. We divided the deep earthquake events into 9 groups by their spatial proximity using the k-means clustering method (Hartigan and Wong 1979). These 9 groups include 2 intermediate-depth groups (depth from 60 km to 300 km) and 7 deep-focus groups (depth greater than 300 km). Our inversion results show that the inverted TTI symmetry axes are perpendicular to the slab interface for two intermediate-depth groups (consistent with dehydration metamorphic reactions) and parallel to the slab interface for 7 deep-focus group. The shear wave anisotropy is best resolved

  12. Danish Register of chronic obstructive pulmonary disease

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    Lange P

    2016-10-01

    Full Text Available Peter Lange,1,2 Sandra Søgaard Tøttenborg,1 Anne Dichmann Sorknæs,3 Jørgen Steen Andersen,4 Mette Søgaard,5 Henrik Nielsen,5 Reimar Wernich Thomsen,5 Katrine Abildtrup Nielsen6 1Section of Social Medicine, Department of Public Health, University of Copenhagen, 2Lung Diseases Department, Respiratory Medicine Section, Lung Diseases Department, Hvidovre Hospital, University of Copenhagen, Copenhagen, 3Medical Department, Odense Universitetshospital–Svendborg Hospital, Svendborg, 4Danish College of General Practitioners, Copenhagen, 5Department of Clinical Epidemiology, Aarhus University Hospital, 6Registry Support Centre of Clinical Quality and Health Informatics (West, Århus, Denmark Aim of database: The Danish Register of Chronic Obstructive Pulmonary Disease (DrCOPD is a nationwide database aiming to describe the quality of treatment of all patients with chronic obstructive pulmonary disease (COPD in Denmark. Study population: DrCOPD comprises data on all patients with a diagnosis of COPD. In the hospital setting, both in- and outpatients are included. In the setting of the general practice (GP, DrCOPD aims to include all patients with a COPD diagnosis who attend an annual control visit for COPD. Main variables: DrCOPD includes information on forced expiratory volume in 1 second, smoking status, body mass index, dyspnea, treatment modalities such as rehabilitation, smoking cessation, medical treatment, and the use of noninvasive ventilation during hospitalization due to exacerbations. The outcome variables include frequency of readmission and death 30 days after discharge from hospital. Descriptive data: Since 2008, the registration in the Danish hospitals has gradually become more comprehensive. In 2014, ~90% of 16,106 eligible patients had complete data sets that showed an improvement in the processes describing quality of care, including increased offering of smoking cessation, rehabilitation, and correct treatment with inhaled

  13. The impact of comorbidity on cancer survival: a review

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    Søgaard M

    2013-11-01

    Full Text Available Mette Søgaard,1 Reimar Wernich Thomsen,1 Kristine Skovgaard Bossen,2 Henrik Toft Sørensen,1 Mette Nørgaard1 1Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; 2Danish Cancer Society, Copenhagen, Denmark Background: A number of studies have shown poorer survival among cancer patients with comorbidity. Several mechanisms may underlie this finding. In this review we summarize the current literature on the association between patient comorbidity and cancer prognosis. Prognostic factors examined include tumor biology, diagnosis, treatment, clinical quality, and adherence. Methods: All English-language articles published during 2002–2012 on the association between comorbidity and survival among patients with colon cancer, breast cancer, and lung cancer were identified from PubMed, MEDLINE and Embase. Titles and abstracts were reviewed to identify eligible studies and their main results were then extracted. Results: Our search yielded more than 2,500 articles related to comorbidity and cancer, but few investigated the prognostic impact of comorbidity as a primary aim. Most studies found that cancer patients with comorbidity had poorer survival than those without comorbidity, with 5-year mortality hazard ratios ranging from 1.1 to 5.8. Few studies examined the influence of specific chronic conditions. In general, comorbidity does not appear to be associated with more aggressive types of cancer or other differences in tumor biology. Presence of specific severe comorbidities or psychiatric disorders were found to be associated with delayed cancer diagnosis in some studies, while chronic diseases requiring regular medical visits were associated with earlier cancer detection in others. Another finding was that patients with comorbidity do not receive standard cancer treatments such as surgery, chemotherapy, and radiation therapy as often as patients without comorbidity, and their chance of

  14. Mathematical modelling of anisotropy of illite-rich shale

    Science.gov (United States)

    Chesnokov, E.M.; Tiwary, D.K.; Bayuk, I.O.; Sparkman, M.A.; Brown, R.L.

    2009-01-01

    singularity point may even vanish. The Thomsen parameters are helpful in fluid type indication in shale. An indicator of gas-filled aligned cracks is ?? > ??. If aligned cracks in illite-rich shale are brine-filled, ?? ?? and decreased values of Vp/Vs in the vertical direction as in the case of gas-filled cracks. In the presence of vertically aligned cracks, shales exhibit distinctly revealed features of orthorhombic symmetry. The results have important applications where seismic measurements are applied to predict the maturity state of the shale. ?? 2009 The Authors Journal compilation ?? 2009 RAS.

  15. Animal models of chronic wound care: the application of biofilms in clinical research

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    Trøstrup H

    2016-11-01

    Full Text Available Hannah Trøstrup,1 Kim Thomsen,1 Henrik Calum,2 Niels Høiby,1,3 Claus Moser1 1Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, 2Department of Clinical Microbiology, Copenhagen University Hospital, Hvidovre, 3Institute for Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark Abstract: Chronic wounds are a substantial clinical problem affecting millions of people worldwide. Pathophysiologically, chronic wounds are stuck in the inflammatory state of healing. The role of bacterial biofilms in suppression and perturbation of host response could be an explanation for this observation. An inhibiting effect of bacterial biofilms on wound healing is gaining significant clinical attention over the last few years. There is still a paucity of suitable animal models to recapitulate human chronic wounds. The etiology of the wound (venous insufficiency, ischemia, diabetes, pressure has to be taken into consideration as underlying pathophysiological mechanisms and comorbidities display tremendous variation in humans. Confounders such as infection, smoking, chronological age, sex, medication, metabolic disturbances, and renal impairment add to the difficulty in gaining systematic and comparable studies on nonhealing wounds. Relevant hypotheses based on clinical or in vitro observations can be tested in representative animal models, which provide crucial tools to uncover the pathophysiology of cutaneous skin repair in infectious environments. Disposing factors, species of the infectious agent(s, and time of establishment of the infection are well defined in suitable animal models. In addition, several endpoints can be involved for evaluation. Animals do not display chronic wounds in the way that humans do. However, in many cases, animal models can mirror the pathological conditions observed in humans, although discrepancies between human and animal wound repair are obvious. The use of animal models should

  16. Health service use among children with and without eczema, asthma, and hay fever

    Directory of Open Access Journals (Sweden)

    Hammer-Helmich L

    2016-09-01

    Full Text Available Lene Hammer-Helmich,1,2 Allan Linneberg,1,3,4 Simon Francis Thomsen,5,6 Line Tang,1 Charlotte Glümer1,7 1Research Center for Prevention and Health, The Capital Region of Denmark, Copenhagen, 2Department of Real World Evidence and Epidemiology, H. Lundbeck A/S, Valby, 3Department of Clinical Experimental Research, Rigshospitalet, 4Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 5Department of Dermatology, Bispebjerg Hospital, 6Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 7Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark Background: Atopic diseases, for example, eczema, asthma, and hay fever, are among the most common chronic diseases of childhood. Knowledge on health service use among children with atopic disease is limited. This study aimed to investigate the total use and costs of health services for children with and without eczema, asthma, and hay fever in a Danish general population. Methods: We conducted a health survey with four complete birth cohorts from the City of Copenhagen. Individual questionnaire data on eczema, asthma, and hay fever for children aged 3, 6, 11, and 15 years were linked to register information on use and costs of health services and prescribed medication and parental education. In total 9,720 children participated (50.5%. Results: We found increased health service use (number of additional consultations per year [95% confidence interval] among children with current eczema symptoms (1.77 [1.29–2.26], current asthma symptoms (2.53 [2.08–2.98], and current hay fever symptoms (1.21 [0.74–1.67], compared with children without these symptoms. We also found increased use of prescribed medication and most subtypes of health services. Current asthma symptoms and current eczema symptoms, but not current hay fever symptoms, increased the health

  17. Partial melting of carbonated pelite at 3-7 GPa and deep cycling of CO2 and H2O in subduction zones

    Science.gov (United States)

    Tsuno, K.; Dasgupta, R.; Danielson, L. R.; Righter, K.

    2011-12-01

    The exchange of water and carbon dioxide between the Earth's crustal rocks and the interior is important for understanding geochemical and geophysical evolution of the planet on geologic timescale. Subduction of pelitic sediments is a key mechanism for volatile introduction to the mantle but the high-pressure behavior of H2O+ CO2 bearing sediments is only constrained for alumina-rich, low-Mg# bulk compositions [1, 2]. However, the ocean-floor sediments for many subduction zones that contain both water and CO2 are alumina-poor and have higher Mg#. To constrain the melting behavior of a model alumina poor carbonated pelite, we performed new experiments. Piston cylinder (3 GPa) and multianvil (5 and 7 GPa) experiments were conducted between 800 and 1150 °C, using a model sediment composition containing 1 wt.% H2O and 5 wt.% CO2 (trace vapor-present at subsolidus conditions). The choice of the bulk composition was aimed to model the loss of siliceous hydrous fluid during the shallow part of subduction. We determined the solidus temperatures between 800 and 850 °C at 3 GPa, 900 and 950 °C at 5 GPa, and calcio-carbonatitic, in contrast to the previous experimental results in alumina-rich and low Mg# bulk composition [1, 2], which showed the stability of Al-rich trachyitic silicate melt at near-solidus temperatures up to 5 GPa, and replaced by carbonate melt only at ≥5.5 GPa. Carbonate-silicate melt immiscibility was observed at 5 GPa, 1100 °C in our study. The phengite-out boundary is located between 850 and 900 °C at 3 GPa, between 1000 and 1100 °C at 5 GPa, and calcio-carbonatitic melt, are likely to be released from relatively hot subducting slabs. The observation of carbonate melt inclusion in cpx and garnet in deeply subducted carbonate-rich sediments [3] might be explained by our experimental results that carbonatite is the stable near-solidus sediment melt at deep sub-arc depths. [1] Thomsen, T.B. and Schmidt, M.W. 2008, EPSL 267, 17-31. [2] Grassi, D. and

  18. Lung perfusion and emphysema distribution affect the outcome of endobronchial valve therapy

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    Thomsen C

    2016-06-01

    Full Text Available Christian Thomsen,1 Dorothea Theilig,2 Dominik Herzog,1 Alexander Poellinger,2 Felix Doellinger,2 Nils Schreiter,3 Vera Schreiter,2 Dirk Schürmann,1 Bettina Temmesfeld-Wollbrueck,1 Stefan Hippenstiel,1 Norbert Suttorp,1 Ralf-Harto Hubner1 1Department of Internal Medicine/Infectious Diseases and Respiratory Medicine, 2Institute of Radiology, 3Institute of Nuclear Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany Abstract: The exclusion of collateral ventilation (CV and other factors affect the clinical success of endoscopic lung volume reduction (ELVR. However, despite its benefits, the outcome of ELVR remains difficult to predict. We investigated whether clinical success could be predicted by emphysema distribution assessed by computed tomography scan and baseline perfusion assessed by perfusion scintigraphy. Data from 57 patients with no CV in the target lobe (TL were retrospectively analyzed after ELVR with valves. Pulmonary function tests (PFT, St George’s Respiratory Questionnaire (SGRQ, and 6-minute walk tests (6MWT were performed on patients at baseline. The sample was grouped into high and low levels at the median of TL perfusion, ipsilateral nontarget lobe (INL perfusion, and heterogeneity index (HI. These groups were analyzed for association with changes in outcome parameters from baseline to 3 months follow-up. Compared to baseline, patients showed significant improvements in PFT, SGRQ, and 6MWT (all P≤0.001. TL perfusion was not associated with changes in the outcome. High INL perfusion was significantly associated with increases in 6MWT (P=0.014, and high HI was associated with increases in forced expiratory volume in 1 second (FEV1, (P=0.012. Likewise, there were significant correlations for INL perfusion and improvement of 6MWT (r=0.35, P=0.03 and for HI and improvement in FEV1 (r=0.45, P=0.001. This study reveals new attributes that associate with positive outcomes for patient selection prior to ELVR

  19. Improving Neuromuscular Monitoring and Reducing Residual Neuromuscular Blockade With E-Learning: Protocol for the Multicenter Interrupted Time Series INVERT Study.

    Science.gov (United States)

    Thomsen, Jakob Louis Demant; Mathiesen, Ole; Hägi-Pedersen, Daniel; Skovgaard, Lene Theil; Østergaard, Doris; Engbaek, Jens; Gätke, Mona Ring

    2017-10-06

    -learning module was implemented in 6 anesthesia departments on 21 November 2016. Currently, we are collecting postintervention data. The final dataset will include data from more than 10,000 anesthesia procedures. We expect to publish the results in late 2017 or early 2018. With a dataset consisting of thousands of general anesthesia procedures, the INVERT study will assess whether an e-learning module can increase anesthetists' use of neuromuscular monitoring. Clinicaltrials.gov NCT02925143; https://clinicaltrials.gov/ct2/show/NCT02925143 (Archived by WebCite® at http://www.webcitation.org/6s50iTV2x). ©Jakob Louis Demant Thomsen, Ole Mathiesen, Daniel Hägi-Pedersen, Lene Theil Skovgaard, Doris Østergaard, Jens Engbaek, Mona Ring Gätke. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 06.10.2017.

  20. Insulin aspart pharmacokinetics: an assessment of its variability and underlying mechanisms.

    Science.gov (United States)

    Rasmussen, Christian Hove; Røge, Rikke Meldgaard; Ma, Zhulin; Thomsen, Maria; Thorisdottir, Rannveig Linda; Chen, Jian-Wen; Mosekilde, Erik; Colding-Jørgensen, Morten

    2014-10-01

    Insulin aspart (IAsp) is used by many diabetics as a meal-time insulin to control post-prandial glucose levels. As is the case with many other insulin types, the pharmacokinetics (PK), and consequently the pharmacodynamics (PD), is associated with clinical variability, both between and within individuals. The present article identifies the main physiological mechanisms that govern the PK of IAsp following subcutaneous administration and quantifies them in terms of their contribution to the overall variability. CT scanning data from Thomsen et al. (2012) are used to investigate and quantify the properties of the subcutaneous depot. Data from Brange et al. (1990) are used to determine the effects of insulin chemistry in subcutis on the absorption rate. Intravenous (i.v.) bolus and infusion PK data for human insulin are used to understand and quantify the systemic distribution and elimination (Pørksen et al., 1997; Sjöstrand et al., 2002). PK and PD profiles for type 1 diabetics from Chen et al. (2005) are analyzed to demonstrate the effects of IAsp antibodies in terms of bound and unbound insulin. PK profiles from Thorisdottir et al. (2009) and Ma et al. (2012b) are analyzed in the nonlinear mixed effects software Monolix® to determine the presence and effects of the mechanisms described in this article. The distribution of IAsp in the subcutaneous depot show an initial dilution of approximately a factor of two in a single experiment. Injected insulin hexamers exist in a chemical equilibrium with monomers and dimers, which depends strongly on the degree of dilution in subcutis, the presence of auxiliary substances, and a variety of other factors. Sensitivity to the initial dilution in subcutis can thus be a cause of some of the variability. Temporal variations in the PK are explained by variations in the subcutaneous blood flow. IAsp antibodies are found to be a large contributor to the variability of total insulin PK in a study by Chen et al. (2005), since only

  1. Nationwide trends in glucose-lowering drug use, Denmark, 1999–2014

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    Christensen DH

    2016-10-01

    Full Text Available Diana Hedevang Christensen,1 Jørgen Rungby,2,3 Reimar Wernich Thomsen1 1Department of Clinical Epidemiology, Aarhus University Hospital, Denmark; 2Department of Pharmacology, University of Aarhus, Aarhus, Denmark; 3Department of Endocrinology, Gentofte University Hospital, Copenhagen, Denmark Purpose: The objective of this study was to examine nationwide population-based time trends in the utilization of all glucose-lowering drugs in Denmark from 1999 to 2014. Methods: Based on nationwide data from the Register of Medicinal Products Statistics, we retrieved sales statistics on glucose-lowering drugs and reported the total number of users and the prevalence of users per 1,000 inhabitants in 1-year intervals for all glucose-lowering drug classes. Results: The annual prevalence of glucose-lowering drug users increased more than twofold from 19 per 1,000 inhabitants in 1999 (n=98,362 to 41 per 1,000 in 2014 (n=233,230. Metformin use increased more than sevenfold during the period and was used by 30 of 1,000 inhabitants in 2014, while the prevalence of insulin use increased 1.8-fold to 13 per 1,000 in 2014. After peaking in 2007, use of sulfonylurea halved to 6 per 1,000 in 2014. Newer drug classes including the glucagon-like peptide 1 receptor agonists, the dipeptidylpeptidase-4 inhibitors, and the sodium–glucose cotransporter 2 inhibitors had reached a considerable position by 2014, with 4 per 1,000, 6 per 1,000, and 0.8 per 1,000 inhabitants, respectively; however, the use of glucagon-like peptide 1 receptor agonists and sodium–glucose cotransporter 2 inhibitors in elderly people remained low. Thiazolidinediones decreased to virtually no use (0.03 per 1,000 in 2014. Conclusion: The use of glucose-lowering drugs has doubled during 1999–2014. The pattern of glucose-lowering drug use has changed substantially reflecting the recommendations of metformin as first-line treatment. The newer glucose-lowering drug classes have been well received

  2. The Danish Centre for Strategic Research in Type 2 Diabetes (DD2 study: implementation of a nationwide patient enrollment system

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    Nielsen JS

    2012-09-01

    Full Text Available Jens Steen Nielsen,1 Reimar W Thomsen,2 Charlotte Steffensen,2 Jens S Christiansen31Department of Endocrinology M, Odense University Hospital, Odense, 2Department of Clinical Epidemiology, 3Department of Endocrinology, Aarhus University Hospital, Aarhus, DenmarkAbstract: This paper aims to describe the patient enrollment system and implementation strategy for the new nationwide Danish Centre for Strategic Research in Type 2 Diabetes (DD2 project. The paper will also describe the design, current content, and pilot testing of the DD2 registration form. The challenge of the DD2 project was to construct a registration system functioning in the entire Danish health care system, where new type 2 diabetes patients are initially met, and with the capacity to enroll 200 newly diagnosed diabetes patients per week nationwide. This requires a fast and simple registration that is part of everyday clinical practice in hospital outpatient clinics and general practitioner (GP clinics. The enrollment system is thus built on a tested, rational design where patients need only one visit and only specific limited data about physical activity, anthropometric measures, and family history of diabetes are collected during a brief patient interview. Later, supplemental data will be extracted by computerized linkage with existing databases. The feasibility of this strategy was verified in a pilot study. For maximum flexibility, three different ways to fill in the DD2 registration form were provided and an interactive webpage was constructed. The DD2 project also involves collection of blood and urine samples from each diabetes patient, to be stored in a biobank. Clinicians may obtain the samples themselves or refer patients to the nearest clinical biochemical department. GPs have the additional option of referring patients to the nearest hospital outpatient diabetes clinic to obtain interview data, clinical data, and samples. At present, the enrollment system is in use at

  3. Incidence and outcomes of patients hospitalized with COPD exacerbation with and without pneumonia

    Directory of Open Access Journals (Sweden)

    Søgaard M

    2016-03-01

    Full Text Available Mette Søgaard,1 Morten Madsen,1 Anders Løkke,2 Ole Hilberg,2 Henrik Toft Sørensen,1 Reimar W Thomsen1 1Department of Clinical Epidemiology, 2Department of Respiratory Medicine, Aarhus University Hospital, Aarhus C, Denmark Background: Pneumonia may be a major contributor to hospitalizations for chronic obstructive pulmonary disease (COPD exacerbation and influence their outcomes.Methods: We examined hospitalization rates, health resource utilization, 30-day mortality, and risk of subsequent hospitalizations for COPD exacerbations with and without pneumonia in Denmark during 2006–2012.Results: We identified 179,759 hospitalizations for COPD exacerbations, including 52,520 first-time hospitalizations (29.2%. Pneumonia was frequent in first-time exacerbations (36.1%, but declined in successive exacerbations to 25.6% by the seventh or greater exacerbation. Pneumonic COPD exacerbations increased 20% from 0.92 per 1,000 population in 2006 to 1.10 per 1,000 population in 2012. Nonpneumonic exacerbations decreased by 6% from 1.74 per 1,000 population to 1.63 per 1,000 population during the same period. A number of markers of health resource utilization were more prevalent in pneumonic exacerbations than in nonpneumonic exacerbations: length of stay (median 7 vs 4 days, intensive care unit admission (7.7% vs 12.5%, and several acute procedures. Thirty-day mortality was 12.1% in first-time pneumonic COPD exacerbations versus 8.3% in first-time nonpneumonic cases (adjusted HR [aHR] 1.20, 95% confidence interval [CI] 1.17–1.24. Pneumonia also predicted increased mortality associated with a second exacerbation (aHR 1.14, 95% CI 1.11–1.18, and up to a seventh or greater exacerbation (aHR 1.10, 95% CI 1.07–1.13. In contrast, the aHR of a subsequent exacerbation was 8%–13% lower for patients with pneumonic exacerbations.Conclusions: Pneumonia is frequent among patients hospitalized for COPD exacerbations and is associated with increased health care

  4. Comparative efficacy of combination bronchodilator therapies in COPD: a network meta-analysis

    Directory of Open Access Journals (Sweden)

    Huisman EL

    2015-09-01

    Full Text Available Eline L Huisman,1 Sarah M Cockle,2 Afisi S Ismaila,3,4 Andreas Karabis,1 Yogesh Suresh Punekar2 1Mapi Group, Real World Strategy and Analytics and Strategic Market Access, Houten, the Netherlands; 2Value Evidence and Outcomes, GlaxoSmithKline, Uxbridge, UK; 3Value Evidence and Outcomes, GlaxoSmithKline R&D, Research Triangle Park, NC, USA; 4Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada Background: Several new fixed-dose combination bronchodilators have been recently launched, and assessing their efficacy relative to each other, and with open dual combinations is desirable. This network meta-analysis (NMA assessed the efficacy of umeclidinium and vilanterol (UMEC/VI with that of available dual bronchodilators in single/separate inhalers. Methods: A systematic literature review identified randomized controlled trials of ≥10 weeks among chronic obstructive pulmonary disease patients (≥40 years, assessing the efficacy of combination bronchodilators in single or separate inhalers. Comparative assessment was conducted on change from baseline in trough forced expiratory volume in 1 second (FEV1, St George’s Respiratory Questionnaire (SGRQ total scores, transitional dyspnea index (TDI focal scores, and rescue medication use at 12 weeks and 24 weeks using an NMA within a Bayesian framework. Results: A systematic literature review identified 77 articles of 26 trials comparing UMEC/VI, indacaterol/glycopyrronium (QVA149, formoterol plus tiotropium (TIO 18 µg, salmeterol plus TIO, or indacaterol plus TIO, with TIO and placebo as common comparators at 12 weeks and approximately 24 weeks. The NMA showed that at 24 weeks, efficacy of UMEC/VI was not significantly different compared with QVA149 on trough FEV1 (14.1 mL [95% credible interval: -14.2, 42.3], SGRQ total score (0.18 [-1.28, 1.63], TDI focal score (-0.30 [-0.73, 0.13], and rescue medication use (0.02 [-0.27, 0.32]; compared with salmeterol plus

  5. Personalized Web-Based Advice in Combination With Well-Child Visits to Prevent Overweight in Young Children: Cluster Randomized Controlled Trial.

    Science.gov (United States)

    van Grieken, Amy; Vlasblom, Eline; Wang, Lu; Beltman, Maaike; Boere-Boonekamp, Magda M; L'Hoir, Monique P; Raat, Hein

    2017-07-27

    used to evaluate the primary outcomes at 36 months of age. At 36 months, we observed no differences between health-related behaviors of children, BMI or the percentage of children having overweight or obesity in the control and intervention group (P>.05). An analysis of the intervention effect revealed that boys benefited from eating breakfast daily, non-Dutch children spent more time being active or playing outdoors, children of low-educated parents and of overweight and obese mothers spent less time watching TV or using the computer, and children of normal weight mothers drank less sweetened beverages (Pchildren's BMI. We conclude that the E-health4Uth Healthy Toddler intervention may be useful for pediatric health care professionals in terms of providing parents with personalized information regarding their child's health-related behaviors. Netherlands Trial Register: NTR1831; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1831 (Archived by WebCite at http://www.webcitation.org/6mm5YFOB0). ©Amy van Grieken, Eline Vlasblom, Lu Wang, Maaike Beltman, Magda M Boere-Boonekamp, Monique P L'Hoir, Hein Raat. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 27.07.2017.

  6. The reporting characteristics of bovine respiratory disease clinical intervention trials published prior to and following publication of the REFLECT statement.

    Science.gov (United States)

    Totton, Sarah C; Cullen, Jonah N; Sargeant, Jan M; O'Connor, Annette M

    2018-02-01

    The goal of the REFLECT Statement (Reporting guidElines For randomized controLled trials in livEstoCk and food safeTy) (published in 2010) was to provide the veterinary research community with reporting guidelines tailored for randomized controlled trials for livestock and food safety. Our objective was to determine the prevalence of REFLECT Statement reporting of items 1-19 in controlled trials published in journals between 1970 and 2017 examining the comparative efficacy of FDA-registered antimicrobials against naturally acquired BRD (bovine respiratory disease) in weaned beef calves in Canada or the USA, and to compare the prevalence of reporting before and after 2010, when REFLECT was published. We divided REFLECT Statement, items 3, 5, 10, and 11 into subitems, because each dealt with multiple elements requiring separate assessment. As a result, 28 different items or subitems were evaluated independently. We searched MEDLINE ® and CABI (CAB Abstracts ® and Global Health ® ) (Web of Science™) in April 2017 and screened 2327 references. Two reviewers independently assessed the reporting of each item and subitem. Ninety-five references were eligible for the study. The reporting of the REFLECT items showed a point estimate for the prevalence ratio >1 (i.e. a higher proportion of studies published post-2010 reported this item compared to studies published pre-2010), apart from items 10.3, i.e., item 10, subitem 3 (who assigned study units to the interventions), 13 (the flow of study units through the study), 16 (number of study units in analysis), 18 (multiplicity), and 19 (adverse effects). Fifty-three (79%) of 67 studies published before 2010 and all 28 (100%) papers published after 2010 reported using a random allocation method in either the title, abstract, or methods (Prevalence ratio = 1.25; 95% CI (1.09,1.43)). However, 8 studies published prior to 2010 and 7 studies published post-2010 reported the term "systematic randomization" or variations of

  7. Comparative efficacy of long-acting muscarinic antagonist monotherapies in COPD: a systematic review and network meta-analysis

    Directory of Open Access Journals (Sweden)

    Ismaila AS

    2015-11-01

    Full Text Available Afisi Segun Ismaila,1,2 Eline L Huisman,3 Yogesh Suresh Punekar,4 Andreas Karabis31Value Evidence and Outcomes, GlaxoSmithKline, Research Triangle Park, NC, USA; 2Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; 3Real World Strategy and Analytics, Mapi Group, Houten, the Netherlands; 4Value Evidence and Outcomes, GlaxoSmithKline, Uxbridge, UKBackground: Randomized, controlled trials comparing long-acting muscarinic antagonist (LAMA efficacy in COPD are limited. This network meta-analysis (NMA assessed the relative efficacy of tiotropium 18 µg once-daily (OD and newer agents (aclidinium 400 µg twice-daily, glycopyrronium 50 µg OD, and umeclidinium 62.5 µg OD.Methods: A systematic literature review identified randomized, controlled trials of adult COPD patients receiving LAMAs. A NMA within a Bayesian framework examined change from baseline in trough forced expiratory volume in 1 second (FEV1, transitional dyspnea index focal score, St George’s Respiratory Questionnaire score, and rescue medication use.Results: Twenty-four studies (n=21,311 compared LAMAs with placebo/each other. Aclidinium, glycopyrronium, tiotropium, and umeclidinium, respectively, demonstrated favorable results versus placebo, for change from baseline (95% credible interval in 12-week trough FEV1 (primary endpoint: 101.40 mL [77.06–125.60]; 117.20 mL [104.50–129.90]; 114.10 mL [103.10–125.20]; 136.70 mL [104.20–169.20]; 24-week trough FEV1 (128.10 mL [84.10–172.00]; 135.80 mL [123.10–148.30]; 106.40 mL [95.45–117.30]; 115.00 mL [74.51–155.30]; 24-week St George’s Respiratory Questionnaire score (-4.60 [-6.76 to -2.54]; -3.14 [-3.83 to -2.45]; -2.43 [-2.92 to -1.93]; -4.69 [-7.05 to -2.31]; 24-week transitional dyspnea index score (1.00 [0.41–1.59]; 1.01 [0.79–1.22]; 0.82 [0.62–1.02]; 1.00 [0.49–1.51]; and 24-week rescue medication use (data not available; -0.41 puffs/day [-0.62 to -0.20]; -0.52 puffs/day [-0

  8. Clinical and molecular diagnosis of a Costa Rican family with autosomal recessive myotonia congenita (Becker disease carrying a new mutation in the CLCN1 gene

    Directory of Open Access Journals (Sweden)

    Fernando Morales

    2008-03-01

    Full Text Available Myotonia congenita is a muscular disease characterized by myotonia, hypertrophy, and stiffness. It is inherited as either autosomal dominant or recessive known as Thomsen and Becker diseases, respectively. Here we confirm the clinical diagnosis of a family diagnosed with a myotonic condition many years ago and report a new mutation in the CLCN1 gene. The clinical diagnosis was established using ocular, cardiac, neurological and electrophysiological tests and the molecular diagnosis was done by PCR, SSCP and sequencing of the CLCN1 gene. The proband and the other affected individuals exhibited proximal and distal muscle weakness but no hypertrophy or muscular pain was found. The myotatic reflexes were lessened and sensibility was normal. Electrical and clinical myotonia was found only in the sufferers. Slit lamp and electrocardiogram tests were normal. Two affected probands presented diminution of the sensitive conduction velocities and prolonged sensory distal latencies. The clinical spectrum for this family is in agreement with a clinical diagnosis of Becker myotonia. This was confirmed by molecular diagnosis where a new disease-causing mutation (Q412P was found in the family and absent in 200 unaffected chromosomes. No latent myotonia was found in this family; therefore the ability to cause this subclinical sign might be intrinsic to each mutation. Implications of the structure-function-genotype relationship for this and other mutations are discussed. Adequate clinical diagnosis of a neuromuscular disorder would allow focusing the molecular studies toward the confirmation of the initial diagnosis, leading to a proper clinical management, genetic counseling and improving in the quality of life of the patients and relatives. Rev. Biol. Trop. 56 (1: 1-11. Epub 2008 March 31.La miotonía congénita es una enfermedad muscular caracterizada por miotonía, hipertrofia y rigidez. Se presenta con dos patrones de herencia, autosómica dominante en cuyo

  9. EDITORIAL: The 24th Nordic Semiconductor Meeting The 24th Nordic Semiconductor Meeting

    Science.gov (United States)

    Páll Gunnlaugsson, Haraldur; Nylandsted Larsen, Arne; Uhrenfeldt, Christian

    2012-03-01

    AndersenAalborg University, Aalborg, Denmark Pia BomholtAarhus University, Aarhus, Denmark Hafliði P GíslasonUniversity of Iceland, Reykjavik, Iceland Haraldur Páll GunnlaugssonAarhus University, Aarhus, Denmark John HansenAarhus University, Aarhus, Denmark Britta JohansenAarhus University, Aarhus, Denmark Volodymyr KhranovskyyLinköping University, Linköping, Sweden Arne Nylandsted LarsenAarhus University, Denmark Helge MalmbekkUniversity of Oslo, Oslo, Norway Erik Stensrud MarsteinInstitute for Energy Technology, Kjeller, Norway Antonio MartiUniversidad Politécnica de Madrid, Madrid, Spain Torben MølholtUniversity of Iceland, Reykjavik, Iceland Sveinn ÓlafssonUniversity of Iceland, Reykjavik, Iceland Thomas PedersenTechnical University of Denmark, Kgs. Lyngby, Denmark Thomas Garm PedersenAalborg University, Aalborg, Denmark Dirch Hjorth PetersenTechnical University of Denmark, Kgs. Lyngby, Denmark Vincent QuemenerUniversity of Oslo, Oslo, Norway Henry RadamsonKTH Royal Institute of Technology, Kista, Sweden Bahman RaeissiUniversity of Oslo, Oslo, Norway Jonatan SlotteAalto University, Aalto, Finland Xin SongUniversity of Oslo, Oslo, Norway Einar Örn SveinbjörnssonUniversity of Iceland, Reykjavik, Iceland Mikael SyväjärviLinköping University, Linköping, Sweden Chi Kwong TangUniversity of Oslo, Oslo, Norway Erik V ThomsenTechnical University of Denmark, Kgs. Lyngby, Denmark Christian UhrenfeldtAarhus University, Aarhus, Denmark Hans Ulrik UlriksenAalborg University, Aalborg, Denmark Muhammad UsmanKTH Royal Institute of Technology, Kista, Sweden Lasse VinesUniversity of Oslo, Oslo, Norway Ulrich WahlUnidade de Física e Aceleradores, Sacavém, Portugal Helge WemanNTNU, Trondheim, Norway Gerd WeyerAarhus University, Denmark

  10. On the footprint of anisotropy on isotropic full waveform inversion: the Valhall case study

    Science.gov (United States)

    Prieux, Vincent; Brossier, Romain; Gholami, Yaser; Operto, Stéphane; Virieux, Jean; Barkved, O. I.; Kommedal, J. H.

    2011-12-01

    The validity of isotropic approximation to perform acoustic full waveform inversion (FWI) of real wide-aperture anisotropic data can be questioned due to the intrinsic kinematic inconsistency between short- and large-aperture components of the data. This inconsistency is mainly related to the differences between the vertical and horizontal velocities in vertical-transverse isotropic (VTI) media. The footprint of VTI anisotropy on 2-D acoustic isotropic FWI is illustrated on a hydrophone data set of an ocean-bottom cable that was collected over the Valhall field in the North Sea. Multiscale FWI is implemented in the frequency domain by hierarchical inversions of increasing frequencies and decreasing aperture angles. The FWI models are appraised by local comparison with well information, seismic modelling, reverse-time migration (RTM) and source-wavelet estimation. A smooth initial VTI model parameterized by the vertical velocity V0 and the Thomsen parameters δ and ɛ were previously developed by anisotropic reflection traveltime tomography. The normal moveout (?) and horizontal (?) velocity models were inferred from the anisotropic models to perform isotropic FWI. The VNMO models allows for an accurate match of short-spread reflection traveltimes, whereas the Vh model, after updating by first-arrival traveltime tomography (FATT), allows for an accurate match of first-arrival traveltimes. Ray tracing in the velocity models shows that the first 1.5 km of the medium are sampled by both diving waves and reflections, whereas the deeper structure at the reservoir level is mainly controlled by short-spread reflections. Starting from the initial anisotropic model and keeping fixed δ and ɛ models, anisotropic FWI allows us to build a vertical velocity model that matches reasonably well the well-log velocities. Isotropic FWI is performed using either the NMO model or the FATT model as initial model. In both cases, horizontal velocities are mainly reconstructed in the first

  11. IR-RF dating on K-feldspar: tracing environmental changes in the Middle Pleistocene?

    Science.gov (United States)

    Kreutzer, Sebastian; Frouin, Marine; Krishna Murari, Madhav; Fuchs, Markus; Mercier, Norbert

    2017-04-01

    In Quaternary sciences, luminescence dating (OSL, TL, RF) yielded paramount importance due to its capability to trace the geomorphological process itself. However, every method has its own limitation and, e.g., the choice of a mineral depends on its local availability and mineral specific characteristic. Since quartz has been proved as reliable dosimeter, but its usual dose saturation level of ca. 150 Gy might be not sufficient in particular cases, feldspar grains are preferred for dating events where higher saturation limits are desired or quartz is not available. However, feldspar suffers from anomalous fading and the efforts undertaken during the last decades to overcome this challenge varied in their success. By contrast, infrared radiofluorescence (IR-RF) of K-feldspar (Trautmann et al., 1999) seems to offer a promising alternative, but until date it has been rarely applied. Likely reasons for this lack of attention are a shortage of commercially available measurement equipment until the recent past and serious methodological doubts that had been raised in the literature (e.g., Buyleart et al., 2012). At the IRAMAT-CRP2A the formerly proposed IR-RF single aliquot regenerative dose (SAR) protocol approach (IRSAR, Erfurt et al., 2003) for K-feldspar grains have been adapted and enhanced (Frouin et al., 2015; Huot et al., 2015; Frouin et al., 2017) using (a) sample adapted bleaching settings and (b) a stimulation at higher temperatures. Together with more recent methodological findings, we present the advantage and the limitations of using the IR-RF dating approach for establishing reliable chronologies on believed Middle Pleistocene sediments. References. Buylaert, J.P., Jain, M., Murray, A.S., Thomsen, K.J., Lapp, T., 2012. IR-RF dating of sand-sized K-feldspar-extracts: A test of accuracy. Radiation Measurements 47, 759-765. Erfurt, G., Krbetschek, M.R., 2003. IRSAR - A single-aliquot regenerative-dose dating protocol applied to the infrared radiofluorescence

  12. Brittle Creep of Tournemire Shale: Orientation, Temperature and Pressure Dependences

    Science.gov (United States)

    Geng, Zhi; Bonnelye, Audrey; Dick, Pierre; David, Christian; Chen, Mian; Schubnel, Alexandre

    2017-04-01

    Time and temperature dependent rock deformation has both scientific and socio-economic implications for natural hazards, the oil and gas industry and nuclear waste disposal. During the past decades, most studies on brittle creep have focused on igneous rocks and porous sedimentary rocks. To our knowledge, only few studies have been carried out on the brittle creep behavior of shale. Here, we conducted a series of creep experiments on shale specimens coming from the French Institute for Nuclear Safety (IRSN) underground research laboratory located in Tournemire, France. Conventional tri-axial experiments were carried under two different temperatures (26˚ C, 75˚ C) and confining pressures (10 MPa, 80 MPa), for three orientations (σ1 along, perpendicular and 45˚ to bedding). Following the methodology developed by Heap et al. [2008], differential stress was first increased to ˜ 60% of the short term peak strength (10-7/s, Bonnelye et al. 2016), and then in steps of 5 to 10 MPa every 24 hours until brittle failure was achieved. In these long-term experiments (approximately 10 days), stress and strains were recorded continuously, while ultrasonic acoustic velocities were recorded every 1˜15 minutes, enabling us to monitor the evolution of elastic wave speed anisotropy. Temporal evolution of anisotropy was illustrated by inverting acoustic velocities to Thomsen parameters. Finally, samples were investigated post-mortem using scanning electron microscopy. Our results seem to contradict our traditional understanding of loading rate dependent brittle failure. Indeed, the brittle creep failure stress of our Tournemire shale samples was systematically observed ˜50% higher than its short-term peak strength, with larger final axial strain accumulated. At higher temperatures, the creep failure strength of our samples was slightly reduced and deformation was characterized with faster 'steady-state' creep axial strain rates at each steps, and larger final axial strain

  13. The Danish Cardiac Rehabilitation Database

    Directory of Open Access Journals (Sweden)

    Zwisler AD

    2016-10-01

    Full Text Available Ann-Dorthe Zwisler,1 Henriette Knold Rossau,1 Anne Nakano,2,3 Sussie Foghmar,4 Regina Eichhorst,5 Eva Prescott,6 Charlotte Cerqueira,7 Anne Merete Boas Soja,4 Gunnar H Gislason,8–10 Mogens Lytken Larsen,5 Ulla Overgaard Andersen,11 Ida Gustafsson,4 Kristian K Thomsen,12 Lene Boye Hansen,13 Signe Hammer,14 Lone Viggers,15 Bo Christensen,16 Birgitte Kvist,17 Cecilie Lindström Egholm,18 Ole May19 On behalf of the Working Group of Preventive Cardiology and Rehabilitation, Danish Society of Cardiology, and the Working Group of Cardiac Clinical Registries, Danish Society of Cardiology 1Danish Centre for Rehabilitation and Palliative Care, Odense University Hospital and University of Southern Denmark, Odense, 2Department of Clinical Epidemiology, Aarhus University Hospital, 3Registry Support Centre (West – Clinical Quality Improvement & Health Informatics, Aarhus, 4Department of Cardiology, Copenhagen University Hospital, Hvidovre, 5Department of Cardiology, Aalborg University Hospital, Aalborg, 6Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, 7Registry Support Centre (East – Epidemiology and Biostatistics, Research Centre for Prevention and Health, the Capital Region of Denmark, Glostrup, 8Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, 9The Danish Heart Foundation, Copenhagen, 10The National Institute of Public Health, University of Southern Denmark, 11Department of Cardiology, Holbaek Hospital, University of Copenhagen, Copenhagen, 12Department of Cardiology, Hospital of Southwest Jutland, Esbjerg, 13Department of Cardiology, Gentofte Hospital, Gentofte, 14Department of Occupational Therapy and Physiotherapy, Herlev Hospital, Herlev, 15Department of Nutrition, Regional Hospital West Jutland, Holstebro, 16Department of General Medicine, School of Public Health, Aarhus University, Aarhus, 17Department of Health Care and Prevention, Municipality of Frederikshavn, Frederikshavn, 18

  14. Reconstruction of glacier fluctuations in the Mont-Blanc massif, western Alps: a multi-­-method approach

    Science.gov (United States)

    Lehmann, Benjamin; Valla, Pierre G.; King, Georgina E.; Ivy-Ochs, Susan; Christl, Marcus; Herman, Frederic

    2017-04-01

    , mineralogical properties and environmental conditions. Premilary OSL results from rock slices show increasing exposure age (i.e., deeper bleaching of the OSL signal) with sample elevation. Moreover, our results reveal that the bleaching of the OSL signal is occuring within the first 1-3 cm below the rock surface, potentially offering high resolution to date the latest exposure following short-lived glacier fluctuations. REFERENCES Coutterand S., Buoncristani J-.-F. (2006), Pal.og.ographie du dernier maximum glaciaire du Pléistocene récent de la région du Massif du Mont Blanc, France, Quaternaire, 17, (1), 2006, p. 35-.-4. Gosse, J.C, and F.M. Phillips (2001). Terrestrial in situ cosmogenic nuclides: theory and application. Quaternary Science Reviews, 20, 1475-1560. Le Roy, M., Nicolussi, K., Deline, P.,Astrade, L., Edouard, J-L., Miramont, C., Arnaud, F. (2015), Calendar dated glacier variations in the western European Alps during the Neoglacial: the Mer de Glace record, Mont Blanc massif, Quaternary Science Review 108 (2015) 1-22, doi:10.1016. Sohbati, R., Murray A., Jain M., Buylaert J.-P., and Thomsen K. (2011), Investigating the resetting of OSL signals in rock surfaces, Geochronometria, 38 (3), 249_258, doi:10.2478/s13386-011-0029-2. Vincent, C., Harter M., Gilbert A., Berthier D., Six D., (2014). Future fluctuations of Mer de Glace, French Alps, assessed using a parameterized model calibrated with past thickness changes. Annals of Glaciology, 55, 15-24. Wirsig C., Zasadni J., Christl M., Akçar N., Ivy-Ochs S. (2016), Dating the onset of LGM ice surface lowering in the High Alps. Quaternary Science Reviews 143 37-50.

  15. Passive margin high altitude low relief surfaces: old or new? Testing the glacial/periglacial buzzsaw hypothesis on the landscape of Southern Norway.

    Science.gov (United States)

    Berthling, Ivar

    2015-04-01

    investigated on local scales. We test the periglacial 'buzzsaw' by spatial and temporal upscaling from current periglacial solifluction landforms and process rates. Berthling, I., and Etzelmüller, B., 2011, The concept of cryo-conditioning in landscape evolution: Quaternary Research, v. 75, no. 2, p. 378-384. French, H. M., 2007, The Periglacial Environment, John Wiley & Sons, 458 pp Gołędowski, B., Egholm, D. L., Nielsen, S. B., Clausen, O. R., and McGregor, E. D., 2013, Cenozoic erosion and flexural isostasy of Scandinavia: Journal of Geodynamics, v. 70, p. 49-57. LidmarBergstrom, K., Ollier, C. D., and Sulebak, J. R., 2000, Landforms and uplift history of southern Norway: Global and Planetary Change, v. 24, no. 3-4, p. 211-231. Nielsen, S. B., Gallagher, K., Leighton, C., Balling, N., Svenningsen, L., Jacobsen, B. H., Thomsen, E., Nielsen, O. B., Heilmann-Clausen, C., Egholm, D. L., Summerfield, M. A., Clausen, O. R., Piotrowski, J. A., Thorsen, M. R., Huuse, M., Abrahamsen, N., King, C., and Lykke-Andersen, H., 2009, The evolution of western Scandinavian topography: A review of Neogene uplift versus the ICE (isostasy-climate-erosion) hypothesis: Journal of Geodynamics, v. 47, no. 2-3, p. 72-95.

  16. Editörden

    Directory of Open Access Journals (Sweden)

    Nadir Arıcan

    2007-04-01

    Full Text Available Değerli Adli Bilimci’ler, Dergimizin ilk baskısının yapıldığı 1996 yılından 2006 yılı sonuna kadar 11 ciltten oluşan dizisini ara vermeden kesintisiz olarak yayınlanma başarısını gösteren Adli Tıp Bülteni Yayın Kurulu adına saygı ile selamlıyoruz. Dergimizin 12. cildinin ilk sayısı, yayın kurulundaki görev değişikliği ile elinize ulaşıyor. “Adli Tıp Bülteni”ni tüm olumsuz koşullara karşın, siz alana emek veren adli bilimcilerin de büyük desteği ile yayın hayatım başarı ile sürdürdü. Bu başarıda başta editörlerimiz sayın Prof. Dr. Serpil Salaçin ve sayın Prof. Dr. Şebnem Korur Fincancı ile yayın kurulunda görev almış meslektaşlarımıza teşekkür ediyor ve desteklerinin artarak devam edeceğini ümit ediyoruz. Adli Tıp Bülteni, ilk editörü sayın Prof. Dr. Serpil Salaçin’in bültenin 1. sayısında belirttiği amaca uygun olarak, her geçen gün daha da güçlenerek yayın hayatını sürdürmektedir. Yayın akışında zaman zaman kesintiler olsa da, amacı doğrultusunda “alanındaki bilgi akışını sağlama ve bilimsel gelişmelerin önemli bir parçası olma özelliğini” Adli Tıp Uzmanları Derneği’nin resmi bilimsel yayın organı kimliği ile devam ettirmektedir. Hedefleri doğrultusunda uluslararası indekslerce taranan bir dergi olma yolunda ilk adımını atan dergimizin bu alandaki çalışmaları sayın Prof. Dr. Şebnem Korur Fincancı tarafından yürütülmektedir. Görevini genç meslektaşına devretmiş olsa da alanımızdaki uluslar arası deneyimi ile Adli Tıp Bülteni’ni çok farklı noktalara taşıyacağı inancındayım. Bu alanda yapacağı katkılardan dolayı sayın hocama biz kez daha teşekkür etmek istiyorum. Bundan böyle Adli Tıp Bülteni’ne yayınlanmak üzere gönderdiğiniz çalışmalarınızın değerlendirmesini daha hızlı yapabilmek ve baskı aşamasına getirmek amacı ile iletişimi elektronik ortamda yapmaya

  17. MKE Kurumu Yapımı Tabanca Mermileriyle Yapılan Atışlarda El Üzerinde Kalan Atış Artıklarının Alevsiz Atomik Absorpsiyon Spektrofotometri Yöntemiyle Tespiti

    Directory of Open Access Journals (Sweden)

    Muhammet Can

    2005-04-01

    ekonomik olması nedeniyle atış artıklarının analizinde ve sonuçlarm yorumlanmasında en uygun yöntem olduğu kanaatine varıldı. Anahtar kelimeler: Alevsiz Atomik Absorpsiyon Spektrofotometri, atış artıkları, atış yapan elin tespiti, Makine Kimya Endüstrisi Kurumu.

  18. Kadının ve Kaderin “Tırpan”ı Swath Of Woman And Fate

    Directory of Open Access Journals (Sweden)

    Salim DURUKOĞLU

    2013-07-01

    ğımız beyin fırtınasının, belleğimizde açığa çıkaracağı romanların başında Tırpan romanı gelir. Kadın ve kader kavramlarını önce buluşturan sonra ayrıştıran Tırpan romanı; kaderin yaşanmadan önce değil yaşandıktan sonra açığa çıkacağına ve genelde insanın özelde kadının kaderini kendi yazabileceğine duyulan saf inançla kaleme alınan; insanın, özellikle ve öncelikle kadının kaderini / kadersizliğini roman türünün olanakları içinde sorgulayan, sınıf çatışmasından, Marksist ideolojinin nefes alışlarına, feminist bakış açılarına kadar genişleyen, tezli yapıtlardan biri ve belki de ilk akla gelenidir. Zihnimizde geçmişte kullanılan bir imgeden miras, elinde tırpan, can biçen Azrail motifi ile de buluşan tırpan silueti, bu romanda bir tarım aleti olmanın çok ötesinde bir işlev üstlenir. Tırpan, Azrail’in elinden kadının eline geçer ve kadın, varlık ve özgürlük alanına saygı duymayan erkeği bu alet ile cezalandırırken, kaderine sahip çıkmış, kaderini kendi elleriyle ve tırpan marifetiyle de yazmış olur. Yazarın elinde tırpan amaç ve araç işlevini koruyacak ancak sonuçları itibarıyla, Bolşevik devrimin orak, çekiç nesnesi gibi, kadın devriminin sembol nesnesine dönüşecektir. Kızların, zorla evlendirilmelerine karşı edilgen bir tepki olarak kendini asmalarını direniş değil kaçış olarak gören, bunun yerine savaşçı, etken ve eylemci bir kadın ruhu ile zihniyeti yaratmak isteyen yazar; son tahlilde bu kurgu üzerinden kaderci Türk toplumuna ve bahusus Türk kadınına kaderine sahip çıkabileceği, hayatına yön verebileceği inancını aşılamak ister, bir bilinç değişimi teklif ve telkin eder.

  19. Cultural Memory of the 1970s Turkey the Psychological Effects of State Oppression on the Imprisoned Individual in the March 12th Novel ‘Büyük Gözaltı’ 1970’li Yıllar Türkiye’sinin Kültürel Hafızası 12 Mart Romanı 'Büyük gözaltı'nda Devlet Baskısının Mahkȗm Birey Üzerinde Beliren Psikolojik Etkileri

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    Ahmet ALVER

    2012-09-01

    ın ilk romanı olan Büyük Gözaltı, Türkiye’de 12 Mart 1971 askeri müdahelesi sonrası, yazarın kendisi de dahil olmak üzere birçok sol görüşlü entellektüelin tecrübe ettiği döneme dair acı gerçekleri yansıtır. Roman, 1970 yıllar Türkiye’sinde, askeri müdahele sonrasında sol eğilimli yüzlerce, binlerce akademisyen, yazar, gazeteci, siyasetçi, üniversite öğrencisi ve aktivistin mahkum olduğu, zulme ve işkenceye maruz kaldığı bir dönemin kültürel hafızasını kaydetmesi yönüyle önemli bir rol oynamaktadır. Bu makale Büyük Gözaltı romanında, Michael Foucault’un felsefi ve sosyoloji teorileriyle açıkladığı güç ile ceza ilişkisini, totaliter bir yapıya sahip iktidarın aşırı gücünün, romanın tutuklu kahramanı üzerinde oluşturduğu psikolojik etkileri, bu güç karşısındaki direnç girişimi ve bir süre sonra maruz kaldığı bu güce boyun eğmek zorunda kalarak kendi kendisinin sorgulayıcısı ve suçlayıcısı olma sürecinin sürrealist açıdan incelemektedir. Çalışmada, kahraman suçluluk veya masumiyetinin sorgulanmasından ziyade, orantısız güç denkleminde muktedir olanın gücü karşısında kendi zayıf konumuna karşı göstermiş olduğu psikolojik reaksiyonun sürreal sonuçları ve belirtileri ele alınır.

  20. Impact of vegetation and ecosystems on chlorine(-36) cycling and its modeling: from simplified approaches towards more complex biogeochemical tools

    Science.gov (United States)

    Thiry, Yves; Redon, Paul-Olivier; Gustafsson, Malin; Marang, Laura; Bastviken, David

    2013-04-01

    al., 2012), average Cl residence time in forest soils calculated for Clin and Clorg together was 5-fold higher that the residence time estimated for Clin alone (Redon et al., 2011), locally, Cl amount taken up by certain vegetation types can be larger than annual atmospheric deposits, the Cl in excess being recycled mainly by throughfall (Thiry, 2010), root uptake and chlorine transformation rates in soils are essential to calibrate dynamic compartment models since those processes control the persistence of chlorine in the whole system but data are still deficient for different land uses (Van den Hoof & Thiry, 2012). References: Bastviken, D., Thomsen, F., Svensson, T., Karlsson, S., Sandén, P., Shaw, G., Matucha, M., and Öberg, G. (2007). Chloride retention in forest soil by microbial uptake and by natural chlorination of organic matter. Geochim. Cosmochim. Acta, 71: 3182-3192. Gustavsson, M., Karlsson, S.,Öberg, G.,Sandén, P.,Svensson, T.,Valinia, S.,Thiry, Y. and Bastviken, D. (2012). Organic matter chlorination rates in different boreal soils: the role of soil organic matter content. Environmental Science & Technology, 46 (3): 1504-1510 Thiry, Y., 2010. Contribution à l'étude du cycle biogéochimique du chlore en écosystème forestier: cas d'un peuplement de pin sylvestre. Rapport Andra n° ENV.NT.ASTR.10.0068. IAEA (2010). Handbook of parameter values for the prediction of radionuclide transfer to humans in terrestrial and freshwater environments. Technical Report Series n° 472, Vienna, Austria. Öberg, G. (1998). Chloride and organic chlorine in soil. Acta hydrochimica et hydrobiologica, 26 (3): 137-144. Redon, P-O., Abdelouas, A., Bastviken, D., Cecchini, S. Nicolas, M. and Thiry, Y. (2011). Chloride and organic chlorine in forest soils: storage, residence times, and influence of ecological conditions. Environmental Science & Technology, 45: 7202-7208. Redon, P-O., Jolivet, C., Saby, N., Abdelouas, A.and Thiry, Y. (2012). Occurrence of natural organic

  1. EDITORIAL: Focus on Carbon Nanotubes

    Science.gov (United States)

    2003-09-01

    .4 nm single-walled carbon nanotubes templated in the channels of AlPO4-5 single crystals Z K Tang, N Wang, X X Zhang, J N Wang, C T Chan and Ping Sheng Lattice dynamics and symmetry of double wall carbon nanotubes M Damnjanovic, E Dobardzic, I Milosevic, T Vukovic and B Nikolic Optical characterization of single-walled carbon nanotubes synthesized by catalytic decomposition of alcohol Shigeo Maruyama, Yuhei Miyauchi, Yoichi Murakami and Shohei Chiashi Christian Thomsen, Technische Universität Berlin, Germany Hiromichi Kataura, Tokyo Metropolitan University, Japan

  2. HOW TO DATE YENISEI INSCRIPTIONS? YENİSEY YAZITLARI NASIL TARİHLENDİRİLEBİLİR?

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    Erhan AYDIN

    2012-06-01

    Full Text Available Yenisei inscriptions are inscriptions along the Yenisei River having a total number of 250 and thought to have been erected by the Kyrgyz. Among these inscriptions, although the first discovered one was Uybat III (E 32 Inscription, not much had been known about the characteristics of the alphabet and who they belonged to until the inscriptions remained from the Second East Turkic Khanate was found in 1889 by N. Yadrintsev. After the decipherment of the letters in this alphabet by Thomsen, researches mostly focused on the Mongolian area, and attempts were also made to read these inscriptions. In this sense, we should mention the names Radloff, S. Ye. Malov and H. N. Orkun. None of the Yenisei inscriptions bear a date. Maybe they did not have advanced calendar systems to be used in the inscriptions. The common characteristic of almost every inscription is that they mention, rather than historical events, what the hero of the inscription did, why he died, and longing for family members, homeland, sky and sun as told from his mouth; as a result, they did not caught the attention of researches apart from scientists on Turkish language. In this article, 170 inscriptions, whose texts are available, have been analyzed in detail, and our attention has been devoted to the narrations in the texts which might be dated. It has been attempted to determine at least when a few of the inscriptions were erected Yenisey yazıtları, Yenisey Irmağı boyunca, Kırgızlar tarafından dikildiği sanılan ve bugün toplam sayısı 250’ye yaklaşan yazıtlardır. Bu yazıtlardan Uybat III (E 32 Yazıtı ilk bulunan yazıt olduğu hâlde N. Yadrintsev tarafından 1889 yılında II. Doğu Türk Kağanlığı’ndan kalan yazıtlar bulununcaya kadar bu yazıtların kimlere ait olduğu ve alfabenin niteliği hakkında pek bir şey bilinmiyordu. Thomsen’in bu alfabedeki harfleri çözmesinden sonra çalışmalar, daha çok Moğolistan bölgesi üzerinde yo

  3. Stress-Induced Seismic Anisotropy Revisited Nouveau regard sur l'anisotropie sismique induite par les contraintes

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    Rasolofosaon P.

    2006-12-01

    S-wave polarized in the coordinate planes. The nearly exhaustive collection of experimental data on seismic anisotropy in rocks (considered as transverse isotropic by Thomsen (1986 show that elliptical anisotropy is more an exception than a rule. Since stress-induced anisotropy is essentially elliptical when restricted to transversely isotropic media, as a consequence this work clearly shows that stress can be practically excluded as a unique direct cause of elastic anisotropy in rocks. Ce résumé contient des formules (*** qui ne peuvent s'afficher à l'écran Un principe général esquissé par P. Curie (1894 concernant l'influence de la symétrie sur les phénomènes physiques dit, en langage actuel, que le groupe de symétrie des causes est un sous-groupe du groupe de symétrie des effets. Par exemple, en ce qui concerne l'anisotropie sismique induite par les contraintes, la symétrie la plus complexe présentée par un milieu initialement isotrope, sous contrainte triaxiale, est orthorhombique ou orthotrope, caractérisée par trois plans de symétrie orthogonaux deux à deux (Nur, 1971. À d'autres égards, Schwartz et al. (1994 ont montré que deux modèles de roches très différents, un modèle fissuré et un modèle granulaire faiblement consolidé, conduisent toujours à une anisotropie elliptique quand ils sont soumis à une contrainte uniaxiale. La question posée est la suivante : est-ce que ce résultat est vrai pour tous les modèles de roches ? et, plus généralement, est-ce que les roches initialement isotropes, quand elles sont soumises à une contrainte triaxiale, forment un sous-ensemble bien défini des milieux orthorhombiques ? Sous l'hypothèse d'hyperélasticité isotrope non linéaire du troisième ordre (c'est-à-dire absence d'hystérésis, et existence d'une fonction d'énergie élastique développée au troisième ordre dans les composantes de la déformation, il est démontré que l'anisotropie de l'onde qP induite par les contraintes est toujours

  4. Evidence for microbial activity in the formation of carbonate-hosted Zn-Pb deposits

    Science.gov (United States)

    Kucha, H.; Raith, J.

    2009-04-01

    composed of Zn-calcite cores and ZnS rims, oxysulphides, thiosulphates, vaesite and chalcedonic silica. Bacterial microtextures in all of the above mentioned deposits are as a rule associated with oxysulphides i.e. compounds with mixed and intermediate sulphur valences (Kucha et al., 1989). The origin of oxysulphides is probably related either directly to incomplete bacterial reduction of the sulphatic sulphur, or reaction of bacterial H2S with sulphatic S present in the fluids. Some of peloids are composed of oxysulphides (Kucha & Stumpfl, 1992; Kucha, 2003). Therefore, an interpretation of the S isotopic signature of bacterial textures should consider not only microbial community structure, but also the oxidative part of the sulphur cycle proceeding through compounds with mixed sulphur valences. References Druschel GK, Labrenz M, Thomsen-Ebert T, Fowler DA, Banfield JF (2002) Geochemical modelling of ZnS in biofilms: An example of ore depositional processes. Economic Geology, v 97, 1319-1329. Fallick, AE, Ashton JH, Boyce AJ, Ellam RM, Russell MJ (2001) Bacteria were responsible fort he magnitude of the world-class hydrothermal base metal sulphide orebody at Navan, Ireland. Economic Geology, v 96, 885 - 890. Haranczyk Cz (1993) Sulphur isotope models of genesis of the Silesian-Cracov Zn-Pb ore deposits. Geological Quarterly, v 37, 307 - 322. Kucha H (1988) Biogenic and non-biogenic concentration of sulfur and metals in the carbonate-hosted Ballinalack Zn-Pb deposit, Ireland. Min. Pet., 38, 171-187. Kucha H, Wouters R, Arkens O (1989) Determination of sulfur and iron valence by microprobe. Scanning Microscopy, 3, no 1, 89-97. Kucha H, Van der Biest J, Viaene W (1990) Peloids in strata bound Zn-Pb deposits and their genetic importance. Min. Deposita, 25, 132-139. Kucha H, Stumpfl EF (1992) Thiosulphates as precursors of banded sphalerite and pyrite at Bleiberg, Austria. Min. Mag., 56, 165-172. Kucha H (2003) Mississippi Valley Type Zn-Pb deposits of Upper Silesia, Poland

  5. RUMELIAN OTTOMAN VOLUNTEERS IN BRITISH P.O.W. CAMPS (1916-1923 *BRİTANYA İMPARATORLUĞU SAVAŞ KAMPLARINDA ESİR DÜŞEN BATI RUMELİ ASILLI OSMANLI GÖNÜLLÜLERİ (1916-1923

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    Redžep ŠKRİJELJ

    2016-11-01

    ye gönderilmiş ve o bölgede İngilizlerin eline esir düşmüştür. Savaşın sonunda Britanya iktidarı 3 bin Müslüman gönüllüyü Rumeli’den İstanbul’a tehcir etmiş, onlar da evlerine geri dönebilmek için Yugoslav Hükûmeti Konsolosluğuna başvurmak zorunda kalmıştır. Uzun süren bu ağır savaş, esirler için hayatta kalma mücadelesi idi. Çok sayıda savaş gazisi Makedonya, Kosova ve Sancak’a yaralı ve hasta durumda dönerek parasızlığa ve açlığa mahkûm olmuştur. Gönüllülerin geri dönüşleri uzun yıllar sürmüştür. Yeni kurulan Sırp, Hırvat ve Sloven Krallığı içinde yaşayan eski Müslüman gönüllülerin daha sonraki yıllarda Çetnik birlikleri tarafından katledilmiştir. Savaş gazilerinin büyük bölümü Mısır’da bulunan Britanya askerî kamplarından ağır fiziksel yaralarla ve psikolojik travmalarla geri dönmüştür. The low success on the Eastern Front had shown the year of 1916 as the most difficult for Austria-Hungary. The strenghtening of the Antanta which was additionally supported by Italy and Romania resulted in dispersing of the Austrian-Hungarian Army on the fronts, and was forced to fight on multiple theaters of war and needed more manpower. Since Imperial Germany transfered all of its troops to the Western Front, Austria-Hungary was forced to request the company of their Ottoman allies to successfully accomplish their war efforts. The improvement of Austro-Hungarian military positions requested a ruthless war propaganda during the period between the fall of 1916 and the spring of 1917 when the XV Ottoman Corpse containing 10 thousand volunteers and recruits has left for the Galician Front. The Ottoman Military explained their excursion to Galicia as a defensive effort against a possible Russian invasion of the Balkan Peninsula. Circumstances which included bad organization, poor discipline, lack of clothes, hunger, a great number of injured and disabled soldiers, lack of vaccines against

  6. Limitations of Expert Evidence

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    Serpil Salaçin

    1997-10-01

    Full Text Available Limitations of Expert Evidence Edited by Stephen Leadbeatter MB ChB MCRPath ISBN 1 86016 029 8 Printed in Great Britain by Cathedral Print Services Ltd, Salisbury, 1996 Kitap 25 Ekim 1994 te The Royal College of Physicians ve The Royal College of Pathologists tarafından düzenlenen konferanstan sonra hekimlere ve avukatlara konuyu tartışmaya açmak için basılmış. Bilirkişi görüşünün temel filozofisinin, bu görevi yapanlar ve bu hizmeti alanların yapabileceklerinin sınırlarının tartışılması amaçlanmış.Seksen altı sayfadan oluşan kitabın fiatı on iki İngiliz Sterlini. Kitap üç bölüm ve bunların altında toplanan on ana başlıktan oluşmakta. Elinize aldığınızda küçük boyutu ve anlaşılır dili ile hemen okunup bitirelecek kitaplardan sanılıyor. En azından ben böyle düşünmüştüm. Ancak daha L A Tuınberg ve A J Bellinham’ın ön yazısında ben çarpıldım. Değerli yazarların kaleme aldığı başlıklar ve gündeme getirdiği tartışmaların tüm Adli Bilimlerle uğraşanların dikkatle okuması gereken cinsten olduğu kanısındayım. Birinci bölüm The Legal Perspective iki anabaşlıktan oluşuyor, The Criminal legal perspective Honour Judje Martin Stephens tarafından yazılmış,bilirkişi olarak görev yapabilmek için belgelenmiş bir eğitim olması gerektiği, mahkemelerde ya da yazılı raporlarda verilebilecek görüşlerin incelikleri tartışılmış. Bu bölümün ikinci anabaşlığı The civil legal perspective avukat Jennifer Cummin tarafından yazılmış. Toplum gözünde bilirkişinin anlamı ve mahkemenin bilirkişi görüşünü değişmez bilimsel doğru gibi algılayarak düştüğü bilimsel yanılgı ve raporlardaki kavram farkı dile getirilmiş. İkinci Bölüm The Medical And Scientific Perspective başlığı altında Roger C Evans MD Clinical evidence başlığında toplumun hasta tedavisi ve bilirkişilik hizmetinden beklentilerinin unrealistik olduğu ve

  7. Persistent Neck and Shoulder Pains among Computer Office Workers: A Longitudinal Study

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    Farideh Sadeghian

    2012-11-01

    S, Gray A. Prevalence and impact of musculoskeletal disorders in New Zealand nurses, postal workers and office workers. Aust N Z J Public Health 2009;33(5:437-41. 14. Eltayeb S, Staal JB, Hassan A, de Bie RA. Work Related Risk Factors for Neck, Shoulder and Arms Complaints: A Cohort Study Among Dutch Computer Office Workers. J Occup Rehabil 2009;19(4:315-22. 15. Lassen CF, Mikkelsen S, Kryger AI, Anders JH. Risk factors for persistent elbow, forearm and hand pain among computer workers. Scand J Work Environ Health 2005;31(2:122-31. 16. Coggon D. Occupational medicine at a turning point. Occup Environ Med 2005;62(5:281-3. 17. Kuorinka I, Jonsson B, Kilbom A, Vinterberg H, Biering-Sørensen F, Andersson G, et al. Standardised Nordic questionnaires for the analysis of musculoskeletal symptoms. Appl Ergon 1987;18(3:233-7. 18. Iwakiri K, Mori I, Sotoyama M, Horiguchi K, Ochiai T, Jonai H, et al. [Survey on visual and musculoskeletal symptoms in VDT workers]. Sangyo Eiseigaku Zasshi 2004;46(6:201-12. (Full Text in Japanese 19. Choobineh A, Nouri E, Arjmandzadeh A, Mohamadbaigi A. Musculoskeletal Disorders among Bank Computer Operators. Iran Occup Health 2006;3(3,4:12-7. 20. Tornqvist EW, Kilbom Å, Vingård E, Alfredsson L, Hagberg M, Theorell T, et al. The influence on seeking care because of neck and shoulder disorders from work-related exposures. Epidemiology 2001;12(5:537-45. 21. Andersen JH, Kaergaard A, Frost P, Thomsen JF, Bonde JP, Fallentin N, et al. Physical, psychosocial, and individual risk factors for neck shoulder pain with pressure tenderness in the muscles among workers performing monotonous, repetitive work. Spine 2002;27(6:660-7. 22. Kaergaard A, Andersen JH. Musculoskeletal disorders of theneck and shoulders in female sewing machine operators: prevalence, incidence, and prognosis. Occup Environ Med. 2000;57(8:528-34. 23. Miranda H, Viikari-Juntura E, Martikainen R, Riihimäki H. A prospective study on knee pain and its risk factors. Osteoarthritis

  8. NARRATIVE: A short history of my life in science A short history of my life in science

    Science.gov (United States)

    Manson, Joseph R.

    2010-08-01

    institute directed by Professor Wolfgang Ernst. The story of how this particular collaboration developed is interesting because it illustrates again how important personal contacts and social interactions are in the progress of science. In 2007 I was contacted by Bodil Holst, then of the TU-Graz and now at the Technical University of Bergen in Norway, about the possibility of having one of her very bright graduate students visit Clemson for a few months as a part of his work in analyzing some He atom scattering data that they had taken on silica glass surfaces. A decade earlier Holst had been a postdoctoral research associate at the Toennies laboratory in Göttingen during several of the summers I was also there and, although we never worked directly together at that time, we had many interesting discussions about science and other subjects. The student, Wolfram Steurer, arrived in Clemson in the middle of the fall semester with his belongings in a bag that was smaller than the guitar he carried strapped over his back. He immediately created for himself a place in our department, and by the time he left three months later we had developed some rudimentary ideas of how to analyze the data he had, and we also suspected that this data might reveal some new aspects of the dynamics of glass surfaces that had not been realized before. Wolfram delved into this problem with a vengeance, and shortly afterwards we began a series of papers involving Holst, Ernst and Steurer and the Graz graduate students, Andreas Apfolter and Mattias Koch, as well as Elin Søndergård of the French CNRS laboratory located at the St Gobain Corporation's research facilities in Paris. It was this initial contact with Holst a decade earlier that eventually led to a productive period of research on glass surfaces, something that I would have never predicted beforehand, but a collaboration that shows every sign of continuing into the future to produce new and interesting results. So, this brings the history

  9. A Glimpse of the Very Early Universal Web

    Science.gov (United States)

    2001-05-01

    important ingredient in the cosmological models is the dark matter that is believed to contribute about 95% of the mass of the universe. The present confirmation of the predictions of the models therefore also indirectly confirms that it is the dark matter that controls the formation of structures in the universe. However, there is still a long way to go before it will be possible to make a more detailed comparison between observations and predictions, e.g., from PR Photo 19e/01 to PR Photo 19a/01 ! Asked about what they consider the most important consequence of their observations, the team responds: " We have shown that we now have an observational method with which we may study the cosmic web in the early universe, and the VLT is a great tool for such studies. The way forward is now pretty clear - we just have to find those faint and distant LEGOs and then do the spectral observations from which we may determine how they are distributed in space ". More information The research described in this press release is the subject of a scientific article by the team, "Detection of a redshift 3.04 filament" , to appear as a Letter to the Editor in the European journal Astronomy & Astrophysics. Notes [1] The team consists of Palle Møller , Johan Fynbo (both at ESO, Garching) and Bjarne Thomsen (Institute of Physics and Astronomy, Aarhus, Denmark). [2] In astronomy, the redshift denotes the fraction by which the lines in the spectrum of an object are shifted towards longer wavelengths. The observed redshift of a distant hydrogen cloud or galaxy gives a direct estimate of the apparent recession velocity as caused by the universal expansion. Since the expansion rate increases with the distance, the velocity is itself a function (the Hubble relation) of the distance to the object. The higher the redshift of an object, the more distant it is and the longer is the look-back time, i.e. the earlier is the corresponding epoch. [3] See also ESO Press Release 13/99 and ESO Press Release 08

  10. Dergilerden Özetler

    Directory of Open Access Journals (Sweden)

    Mete Korkut Gülmen

    1997-10-01

    olmuştur. Ebeveynden yaşayan asemptomatik iyileşen kız kardeşin alınması için adli makamları ikna eden bu çalışmalar sonuçlandığında teşhis kuvvetlenmiştir. AİLE İÇİ ŞİDDET: ADLİ HEKİMLERİN ROLÜ VAR MI? Domestic violence: Do forensic physicians have a role? MM Stark, DJ Jones, J Howitt J Clinical Forensic Med 1997;4:59-63. Güney Londra’da altı ayı aşkın bir sürede aile içi şiddete uğrayan olgularda adli hekimin rolü incelenmiştir. Çalışmanın amacı aile içi şiddetin karakteristik özelliklerini belirlemek, kişilerin öncelikli olarak koruyucu hekimlik birimleri veya diğer benzer organizasyonlarla bağlantılarını sağlamanın ve adli hekim ile kişinin rutin takibini yapan pratisyen hekim arasında doğrudan iletişim kurmanın önemini vurgulamaktır. Çalışmanın sonuç kısmında adli hekimin kişinin iznini alarak kurban ve saldırgandaki (her nekadar pek çoğunda minör yaralanmalar olsa da yaralanmaları belgelemesinin vazgeçilmez rolü, tıbbi tedavide gerekli bilgileri vererek ve koruyucu hekimlik görevini de üstlenerek destek üniteler konusunda gerekli yönlendirmeyi sağlamadaki önemi belirtilmiştir. İŞKENCE MAĞDURLARINDA KRONİK AĞRI Chronic Pain in Torture Survivors AB Thomsen, JB Madsen, KS Nielsen, EJ Eriksen Torture 1997;7(4:118-21. İşkence, yaşamı pek çok farklı şekilde zorlayan ağır sekeller ile ilişkili olabilir. Ağrı işkence kurbanlarında çoğunlukla işkenceden pek çok yıl sonra etkinlik kazanan ve sıkça görülen bir şikayettir. Seçilmiş işkence kurbanlarından oluşan bir grupta titiz bir ağrı analizi hastalarda çeşitli lokalizasyonlarda ağrı şikayetleri olduğunu göstermiştir. Ağrı nosiseptif, vis- eral veya nöropatik olarak tanımlanmıştır. Çalışmadaki bütün hastalar işkence kurbanlarında görülene çok benzer teşhis edilemeyen nöropatik ağrılardan yakınmaktadır. Bu ağrılar ile fiziksel şiddetin dört tipinde ortak olarak

  11. Dergilerden Özetler

    Directory of Open Access Journals (Sweden)

    Şebnem Korur Fincancı

    1999-04-01

    ;112(3:159-62. Yara yaşını belirlemek amacıyla, otoklavda tutulduktan sonra ABC tekniği kullanılarak parafin blok kesitlerinde endotelyal adhezyon molekülü VCAM-1 (CD 106 araştırılmıştır. Damarlar PECAM-1 (CD 31 ile işaretlendikten sonra, VCAM-1 pozitif damarların yüzdesi belirlenmiştir. Örneklerin % 18’inde sağlam cilt endotelyal hücrelerinde VCAM-1 için düşük pozitif boyanma reaksiyonu gözlenmiştir. Yaralı ciltte araştırılan olguların % 51’inde VCAM-1 belirgindir. Yaralanmadan en erken 3 saat, en geç 3,5 gün sonra kuvvetli pozitif boyanma reaksiyonları gözlenmiştir. VCAM-1 için immünhistokimyasal sonuçlar yaralı ve sağlam ciltlerde anlamlı farklılık göstermiştir (P < 0.01. Birkaç olguda postmortem cilt yaralarında VCAM-1 (n = 6 düşük yoğunluklu olarak izlenmiş ve VCAM-l’in ortalamadan kuvvetli pozitifliğe kadar yara vitalitesinin göstergesi olduğu kabul edilmiştir. Özellikle selektinler gibi başka adhezyon moleküllerinin ortaya çıkış düzeyi de değerlendirmeye alınırsa, VCAM-1 adli uygulamada yara yaşını belirlemek amacıyla kullanılabilir. ERKEN POSTMORTEM İNTERVALDE POSTMORTEM KAN TROMBOSİT SAYISI NEDEN VE NASIL DEĞİŞMEKTEDİR? How and why does the platelet count in postmortem blood change during the early postmortem interval? Thomsen H, Kaatsch HJ, Krisch B. Forensic Sci Int 1999 May 17;101(3:185-94. Postmortem kanda trombosit sayısındaki erken postmortem değişiklikleri ve bu değişikliğin nedenlerini trombosotleri sayarak, in vitro hipostatik testler uygulayarak, postmortem kan örneklerinde volüme göre eritrosit yüzdesini belirleyerek, immunohisto- kimya (anti-CD6l, anti-fibrinogen, ve immunoelect- ron mikroskopisi ile (anti-CD62, anti-CD63, anti- thrombospondin inceledik. Başlangıçta gözlenen trombosit sayısındaki artışın hipostatik duruma bağlı olduğu saptandı. Trombosit sayısında izleyen dönemde, devam eden hipostaza rağmen devamlılık göstermeyen düşüş olmas

  12. Journal Abstracts

    Directory of Open Access Journals (Sweden)

    Mete Korkut Gülmen

    1996-07-01

    IMLILIĞI ÖLÜMLERİ VE IIIV VE HEPATİT B ENFEKSİYONLARI SIKLIĞI Drug addict deaths in north and west London and prevalence of HIV and Hepatitis B infection Paterson SC, Vanesis P, Claydon SM. Science Justice 1996;36:85-88. Londra’nın Kuzey ve Batısında 1987-92 yılları arasında uyuşturucu bağımlılığından ölen 176 kişide yapılan bir çalışmada, dokuz kişide HIV, sekiz kişide hepatit B, ve iki kişide her iki enfeksiyon da pozitif bulundu; kişilerin %63’ünde enjeksiyon izleri saptandı. 176 ölümün 155’i direkt olarak uyuşturucu zehirlenmesine bağlanırken, 38’i uyuşturucuların sindirim yolu ile alımı sonrası oluşan komplikasyonlarla ilintili bulundu ve 23’ünün ise ilaçlarla bağlantısız sebeplerden öldüğü saptandı. HIV pozitif olduklarını bilen bağımlılarda diğer popülasyona oranla intihar sayısında hiçbir artış saptanmadı. POSTMORTEM ÖRNEKLERDE, KARBAMAT PESTİSİD ve METOMİL ANALİZİ The analysis of methomyl, a carbamate pesticide, in post-mortem samples Tsatsakis A, Tsakalof A, Michalodimitrakis E. Science Justice 1996;36(l:4l-45. Otopsi doku ve sıvı örneklerindeki, karbamat pesti- sid, metomil’in kantitatif tayini için analitik metotlar ve ekstraksiyon yöntemleri incelendi. Olgu çalışmasındaki analitik sonuçlar metomil’in vücuttaki hızlı metabolizmasını gösterdi. ALKOLİK POPÜLASYONDAKİ ADLİ OTOPSİLERDE GÖRÜLEN MENTAL HASTALIKLAR Mental disease in forensic autopsy population of alcoholics ThomsenJL. Science Justice 1996; 36: 89-92. Kopenhag’da beş yıllık bir sürede adli tıbbi muayenesi yapılan alkolik olgular retrospektif olarak değerlendirildi. Alkoliklerdeki mental hastalıkların sıklığı, alkolik olmayan kontrol gnıbu ile karşılaştırıldı. 2298 ölüm olgusunda, alkoliklerde genel nervozite ve affektif ünipo- lar düzensizliklerin daha yüksek bir frekansta olduğu tesbit edildi. Tekrarlanan intihar girişimlerine alkoliklerde daha sık rastlan