L’audizione di Paolo Sylos Labini dinanzi alla Commissione parlamentare sui problemi del monopolio: quali insegnamenti per il presente. (Paolo Sylos Labini's Testimony at the Italian Parliamentary Inquiry Commission on Competition: Lessons for the Present

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Pierluigi Sabbatini

2016-06-01

Full Text Available The author underlines the contributions of Sylos Labini's testimony at the Italian Parliamentary Inquiry Commission on Competition, held in 1962. He focuses on issues of antitrust enforcement, in terms of: accountability, prioritization of Antitrust interventions and checks on market power. Text of the speech given at the conference "Paolo Sylos Labini e la politica delle riforme", held at Sapienza University of Rome on 04 December 2015, organized by the Accademia dei Lincei and Economia civile.

[The written nursing reports of the asylum "Paolo Pini" of Milan, from 1944 to 1947].

Science.gov (United States)

Negri, Marina; Marchesini, Vanna; De Valerio, Silvio; Soro, Emiliana

2017-01-01

The work provides the analysis of the nursing reports written by the nursing staff on duty at the asylum "Paolo Pini" from 1944 to 1947. description of the nursing report evolution, analyses of the quantitative and qualitative matters. Study of the evolution of the records: enhancement of the description of the patient, integration between medical and nursing assistance, assumption of responsi- bility (for instance through the signature). A sampling of 355 medical records has been analysed. The nursing records have been identified according to the theoretical model of Marisa Cantarelli. They have been compared with the current standard reported in literature. If recognizable signatures were present, they have been checked in the archives of the Province of Milan. 219 records concerning nursing assistance have been selected. The record changed during the years assuming a definite structure, and became a pre printed form; its use spread in all the wards of the hospital. The record deals with nursing assistance needs, and improves during the years becoming more and more detailed and regular. During the analysed time frame, the nursing reports at "Paolo Pini" improve and become more exhaustive and regular; they prove to be part of the medical record, showing a good integration between doctors and nurses activities. The evolution of this tool confirms the need of highlighting and improving the assistance practice.

1983 James B. Macelwane Awards: Donald J. DePaolo

Science.gov (United States)

Wasson, John T.; DePaolo, Donald J.

We honor Don DePaolo with the Macelwane Award for several key contributions to the earth sciences. While a graduate student at Caltech Don recognized that the study of an isotopic parent—daughter pair having the same volatility and the same host phases could eliminate many of the ambiguities that had plagued previous attempts to apply isotopic data to the study of mantle reservoirs and that the 147Sm-143Nd system was such a geochemically coherent pair.Following Gunter Lugmair's pioneering work on meteorites, Don was one of the first to work out laboratory techniques for the study of Sm and Nd; these techniques and the high-precision mass spectrometers of the Wasserburg lab allowed Don and Jerry to demonstrate in several key papers that there were at least two major mantle reservoirs and to examine earth structural models that could account for the observations. Don continues to contribute new ideas to this area; for example, in a paper in press he discusses the use of 176Lu-176Hf results to place constraints on the rate of crustal recycling.

Paolo Sarpi and the first Copernican tidal theory.

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Naylor, Ron

2014-12-01

Despite his demanding religious responsibilities, Paolo Sarpi maintained an active involvement in science between 1578 and 1598- as his Pensieri reveal. They show that from 1585 onwards he studied the Copernican theory and recorded arguments in its favour. The fact that for 1595 they include an outline of a Copernican tidal theory resembling Galileo's Dialogue theory is well known. But examined closely, Sarpi's theory is found to be different from that of the Dialogue in several important respects. That Sarpi was a Copernican by 1592 is revealed by other of his pensieri, whereas at that time we know that Galileo was not. The examination of Sarpi's tidal theory and of the work of Galileo in this period indicates that the theory Sarpi recorded in 1595 was of his own creation. The appreciation that the theory was Sarpi's and that Galileo subsequently came to change his views on the Copernican theory and adopted the tidal theory has major implications for our understanding of the significance of Sarpi's contribution to the Scientific Revolution. Moreover, it appears that several of the most significant theoretical features of the tidal theory published by Galileo in the Dialogue - and which proved of lasting value - were in reality Sarpi's.

Ethical perspectives and ramifications of the Paolo Macchiarini case.

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Teixeira da Silva, Jaime A

2017-01-01

The Paolo Macchiarini case has several ethical ramifications. Professor Macchiarini, formerly of the Karolinska Institutet (KI), became famous for the tracheal surgeries he conducted between 2008 and 2014. His rapid rise to fame was followed by an almost equally rapid fall from grace as official reports, articles in newspapers and television programmes revealed several aspects related to misconduct in his curriculum vitae, professional practices and publishing-related activity. Formal misconduct reports issued by four KI co-workers in late 2014, then again in 2016, coupled with social scandals, including the tricking of a famous US television newscaster into a false marriage, a previous arrest in Italy for apparent bribery, and acute narcissism, all tainted Macchiarini's legend. In the short space of just two years, Macchiarini was no longer remembered for the revolutionary changes he had claimed to have brought about in stem cell research and regenerative medicine. Instead, at least seven dead patients later, Macchiarini faces potential aggravated manslaughter charges and an uphill battle to save his published research, now shrouded in scandal and scientific doubt, from being retracted and scratched out from the list of verified medical science. This paper examines some of the possible ethical ramifications of the Macchiarini case.

The ALICE HMPID detector with the three project leaders: Paolo Martinengo, Eugenio Nappid and Francois Piuz

CERN Multimedia

Saba, A.

2006-01-01

With an active area of about 11m^2 covered with CsI, the HMPID is the largest application of this technology so far. This development started at CERN within the RD26 project under the leadership of Francois Piuz (CERN), now retired. It took fifteen years of research and development to master the method to the current scale and efficiency. During the construction phase the project was led by Eugenio Nappid (INFN Bari, Italy). In August 2006 Paolo Martinengo (CERN) took over the leadership and he will lead the project during the commissioning and exploitation phase.

La fiaccola e la maschera: didascalie in immagini per il pensiero. Un esemplare pendant di Paolo De Matteis / The torch and the mask: captions by images for thought. A pair of paintings by Paolo De Matteis

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Alessandro Rossi

2015-12-01

Full Text Available Abstract  Sintesi caleidoscopica dell’eros latino, le Metamorfosi di Ovidio sono state fondamentale riferimento sin dall’antichità per molti pittori che ne hanno ripreso i temi, cimentandosi anche nel non facile compito di rappresentare nella fissità della realizzazione pittorica la narrazione di ciò che, per definizione, è in movimento: la metamorfosi. Un pendant di dipinti, diviso ora fra Italia e Stati Uniti, raffigurante Apollo e Dafne e Pan e Siringa, rappresenta un significativo caso studio per dare avvio a una riflessione sui sottili rapporti che intercorrono fra l’invenzione del soggetto dovuta al poeta Ovidio, la modalità teorica con cui debba essere rappresentato tale soggetto, elaborata dal filosofo e committente inglese Conte di Shaftesbury e la realizzazione artistica di tale teoria dovuta al pittore cilentano Paolo De Matteis. Scopo ultimo della riflessione è quello di meglio comprendere, tanto storicamente quanto fenomenologicamente, l’intelligenza propria di un linguaggio pittorico che struttura dall’interno le immagini, rendendo efficace la loro capacità di mostrare sia ciò che le parole narrano sia ciò che il pensiero teorizza.   A kaleidoscopic synthesis of the Latin eros, Ovid’s Metamorphoses have been a fundamental point of reference, since ancient times, for the many painters who drew their subject-matter from this text and also undertook the far from simple task of using the static nature of the pictorial medium to represent the narration of what is – by definition – in motion: metamorphosis. A pair of paintings, now divided between Italy and the United States, depicting Apollo and Daphne and Pan and Syrinx, offers a significant case study for an initial reflection on the subtle relationships between the invention of a subject, a text by the poet Ovid, the theoretical mode of representing such a subject, devised by the English philosopher and patron, the Earl of Shaftesbury, and the artistic

The Body as a Frontier: Paolo Volponi and Tiziano Scarpa

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Francesca Negro

2011-06-01

Full Text Available This paper proposes an analysis of some texts by Paolo Volponi and Tiziano Scarpa in which the body reveals the alienation of the protagonist. By the analysis of the texts we reflect on the concept of the Persona as the complex concept of human being in which the physical body, the juridical essence and the sensible entity are unified. The body is a porous barrier, a threshold that the authors use to discover the points of contact and separation with the external world, it’s man’s first space and his first language. In the age of the Body fabrication” some concepts as “the senses feast” by Kristeva, and as the one of Somatisation derive from a recent analysis of the human body and of its relations with the representation of human sensibility. These works describe cases of alienation by mean of a sort of body language, activated by the illness or other specific circumstances, the paper then tries to reconstruct the last changes related to the body concept and to analyse the literary examples in relation to recent theories on fragmentation and dissociative disorders (corps sans organes- Deleuze Guattari The description of this fragmented condition reveals the necessity to rebuild a human integrity, to construct a new concept of human physiology based on an organic vision of the human being. The current dilatation and deflagration of the intimacy then seems to be a strategy to overpass the limits of conscious communication, to impose a new holistic concept of human sensibility

Chromosomenindividualität or Entmischung? The debate between Paolo Della Valle and Edmund B. Wilson.

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Volpone, Alessandro

2015-01-01

At the beginning of the twentieth century, the Italian cytologist Paolo Della Valle developed a theory of instable chromosomes (teoria dei cromosomi labili). He radically criticized the so-called Sutton-Boveri hypothesis (Martins and Martins, Genetics and Molecular Biology, 22:261-271, 1999), focusing on numerical constancy in the species and individuality. On the basis of bibliographical review and personal observations, he maintained that the chromosomes were neither stable bodies, nor permanent structures, but transitory cellular materials, resulting from the periodical rearrangement of the chromatin during the cell division. German and English-speaking biologists reacted. The paper shows some content of the argumentations used by Thomas H. Montgomery and especially Edmund B. Wilson. The discussion was characterized by the same data which is interpretedby different scholars in different ways. And the point is that no one of them had the decisive test to demonstrate his own point of view. Wilson simply invoked on his behalf a certain 'common sense', defending at least a 'high degree of constancy'. The debate waned along with the reception of Morgan's chromosome theory of heredity, but only the advent of molecular biology definitively stated the nature of chromosomes as permanent structures of the cell.

Genetics Home Reference: Angelman syndrome

Science.gov (United States)

... Gentile JK, Tan WH, Horowitz LT, Bacino CA, Skinner SA, Barbieri-Welge R, Bauer-Carlin A, Beaudet ... article on PubMed Central Tan WH, Bacino CA, Skinner SA, Anselm I, Barbieri-Welge R, Bauer-Carlin ...

Réflexions sur le texte (pseudo-littéraire chez Paolo Mantegazza : Un giorno a Madera. Una pagina dell'igiene d'amore

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Edwige Comoy Fusaro

2011-01-01

Full Text Available En 1868, à l'âge de trente-sept ans, l'anthropologue italien Paolo Mantegazza, auteur de nombreux ouvrages de divulgation scientifique, inaugure une nouvelle stratégie de communication avec la publication d'un roman, Un jour à Madère (Un giorno a Madera. En s'adressant au public plus restreint et plus cultivé des romans, Mantegazza tente d'élargir son audience à de nouvelles couches de la population. Cependant, ses motivations restent inchangées. Le genre pseudo-scientifique dissimulait des visées morales : la santé du corps étant liée à la santé morale, ses livres de divulgation véhiculaient essentiellement une ligne de conduite, un décalogue des bonnes mœurs. Avec le nouveau genre pseudo-romanesque, l'auteur dissimule sous la forme alléchante de la fiction narrative des visées médicales, plus précisément prophylactiques. Dans les deux cas, néanmoins, formes et savoirs sont instrumentalisés : la déontologie scientifique et l'esthétique du texte littéraire s'inclinent devant l'idéologie.Nel 1868, il trentasettenne antropologo monzese Paolo Mantegazza, già autore di numerosi libri di divulgazione scientifica, inaugura con la pubblicazione di un romanzo, Un giorno a Madera, una nuova strategia di comunicazione. Rivolgendosi al pubblico dei romanzi, più limitato e più colto, Mantegazza cerca di allargare il proprio lettorato. Tuttavia le sue motivazioni rimangono incambiate. Il genere pseudo-scientifico dissimulava fini moralistici : essendo la salute del corpo legata alla salute morale, i libri di divulgazione trasmettevano essenzialmente un modus operandi, un decalogo dei buoni costumi. Con il nuovo genere pseudo-romanzesco, l'autore dissimula sotto la forma allettante della finzione narrativa fini medici, nella fattispecie profilattici. In ambedue i casi, però, forme e saperi vengono strumentalizzati : la deontologia scientifica e l'estetica del testo letterario cedono il passo all'ideologia.

[The ideas that are seen. Form and perception in Goethe and Paolo Bozzi].

Science.gov (United States)

Giacomoni, Paola

2013-01-01

This article presents a comparative analysis of Paolo Bozzi's experimental phenomenology and of J.W. Goethe's morphological method, which is considered one of the Italian scholar's sources of inspiration. Starting from Bozzi's education within the Gestalt psychology tradition, under the guidance of Gaetano Kanizsa, and taking into account also the recent interest shown for Bozzi by several exponents of the analytic tradition, this work draws attention to the basic features of the methodology adopted by the perceptologist in his work. In this regard, what proves to be fundamental is the role played by the various techniques of inter-observation by means of an active and practical approach to the material, rather than a purely contemplative one. Bozzi's interest in Goethe's naturalistic writings, from the morphological ones to the Farbenlehre (Theory of colours), makes it possible to highlight significant analogies and conceptual continuities with Goethe's epistemology. First of all, a link between these two styles of research is provided by the subject "form," or Gestalt, and its direct, accurate observation, as well as its presence in non-conventional contexts and its non-metaphysical character. Furthermore, it is evident that both authors employ a conception of experiment that is repeatable, conducted almost always in conditions that are open and not of the laboratory. Not less relevant is their scientific style, in which the distinction between the context of discovery and the context of justification plays no role. At the same time the extraordinary communication skills of both authors play a crucial role: their non-academic way of writing accompanied by a sense of rigour and correctness makes the results outstanding and unique.

«A Ca’ Giustinian fu tutto diverso». La mostra di Paolo Veronese a Venezia (1939 / «A Ca’ Giustinian fu tutto diverso» (At Ca’ Giustiniani eveything was different. Paolo Veronese exhibition in Venice (1939

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Matilde Cartolari

2016-12-01

Full Text Available La mostra di Paolo Veronese si svolse a Venezia nel 1939 sotto la direzione di Rodolfo Pallucchini. Promuovendo una ricognizione materiale e critica dell’opera del maestro, la mostra fu l’occasione per effettuare una massiccia campagna di restauri ad opera del bergamasco Mauro Pellicioli e della sua squadra di collaboratori. Agendo sul duplice fronte della museografia e del restauro, Pallucchini si pose in dialogo con le parallele definizioni elaborate in sede istituzionale da Guglielmo Pacchioni e Giulio Carlo Argan. Il presente saggio intende offrire, attraverso materiale archivistico inedito, un’analisi del ruolo della mostra di Veronese nel contesto nazionale e internazionale, ricostruendo con un approccio interdisciplinare le dinamiche teoriche e operative che ne animarono lo svolgimento. Veronese exhibition took place in Venice in 1939 under the direction of Rodolfo Pallucchini. While promoting both material and critical examination of Veronese’s work, the exhibition was an opportunity to undertake a massive restoration, performed by Mauro Pellicioli and his team of collaborators. Pallucchini’s museographical and conservative program was in close relation with the theories promoted by Guglielmo Pacchioni and Giulio Carlo Argan in public administration. This paper intends to offer, through unpublished archival evidence, a detailed analysis of Veronese exhibition in relation to national and international context, in order to understand with an interdisciplinary approach both its theoretical and practical aspects.

27 August 2013 - Signature of an Agreement between KTO Karatay University in Turkey represented by the Dean of Engineering Professor Ali Okatan, CERN represented by Director for Research and Computing Dr Sergio Bertolucci and ALICE Collaboration represented by ALICE Collaboration Spokesperson Dr Paolo Giubellino.

CERN Multimedia

Maximilien Brice

2013-01-01

27 August 2013 - Signature of an Agreement between KTO Karatay University in Turkey represented by the Dean of Engineering Professor Ali Okatan, CERN represented by Director for Research and Computing Dr Sergio Bertolucci and ALICE Collaboration represented by ALICE Collaboration Spokesperson Dr Paolo Giubellino.

Book review. Semeiologia Clinica Veterinaria. (a cura di Paolo Ciaramella

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Manuel Graziani

2014-09-01

Full Text Available Il grado di specializzazione raggiunto nel settore clinico veterinario non è dissimile da quello presente in campo umano, soprattutto se si pensa agli animali d'affezione che sono oramai considerati parte integrante di una società moderna e civile in cui anche il fattore benessere animale ha acquisito importanza non secondaria, in particolare nell'allevamento degli animali da reddito. In questo contesto è sempre più richiesta la figura di uno specialista competente e aggiornato, in grado di risolvere in modo adeguato le problematiche che gli vengono proposte, in un mercato in concorrenza che non contempla imperizia, inesperienza e ignoranza professionale. Lo studio della semeiologia clinica è uno dei primi passi di questo lungo e affascinate cammino che permette di apprendere un metodo di analisi sistematico, affidabile, efficiente e accurato per educare il futuro medico veterinario verso le procedure della buona pratica clinica. La semeiotica insegna ad allenare i propri sensi: a guardare attraverso l'osservazione diretta e indiretta, a sentire ascoltando suoni o rumori, a percepire sensazioni tattili e, non da ultimo, a saper discernere con cognizione e competenza quando ricorrere alle indagini strumentali e di laboratorio; sempre e comunque nella consapevolezza che non possono in nessun modo sostituire l'esame fisico diretto del paziente. Paolo Ciaramella, professore ordinario di Clinica Medica Veterinaria all'Università Federico II di Napoli, presenta così il volume che ha curato: "L'idea di questo libro ha preso forma durante un simposio di medicina interna tenutosi a Torino nel 2008. Con alcuni colleghi presenti si pensò alla possibilità di elaborare un nuovo testo di Semeiotica Medica che potesse ampliare e aggiornare il glorioso Messieri e Moretti, non tanto perché esso avesse perduto il suo valore intrinseco, quanto piuttosto perché nel corso degli anni sono cambiate la patologia animale e con essa la semeiotica e la clinica

Forme di mercato e sistema finanziario. Spunti dalla testimonianza di Sylos Labini alla Commissione parlamentare di inchiesta sui limiti posti alla concorrenza nel campo economico. (Market structure and financial system. Suggestions from Paolo Sylos Labini

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Mario Tonveronachi

2016-03-01

Full Text Available The article builds on the Proceedings of a 1962 Italian Parliamentary enquiry commission on competition, to examine the impact of different market structures on the financial system. The author focuses in particular on the evolution of the banking sector in Italy. Text of the speech given at the conference "Paolo Sylos Labini e la politica delle riforme", held at Sapienza University of Rome on 04 December 2015, organized by the Accademia dei Lincei with Economia Civile.

Should the definition of "sleep hygiene" be antedated of a century? A historical note based on an old book by Paolo Mantegazza, rediscovered. To place in a new historical context the development of the concept of sleep hygiene.

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Gigli, Gian Luigi; Valente, Mariarosaria

2013-05-01

The article contains a historical note on the concept of sleep hygiene, developed in 1977 by Peter Hauri, who developed a set of sleep-promoting rules, considered the fundament for sleep-hygiene techniques. Somnologists, unanimously ascribed to Hauri the fatherhood of the lucky term, while numerous books included at least a section on sleep hygiene. "Inadequate sleep hygiene" was included as a nosological entity in the International Classification of Sleep Disorders. This article intends to demonstrate that the concept of sleep hygiene was developed many years before, thanks to the pioneering work of Paolo Mantegazza, a scientist and a professor in the Medical School of the University of Pavia, Italy. After presenting briefly the history of the University of Pavia and illustrating the profile of Paolo Mantegazza, the article presents the original book published by Mantegazza in 1864 (second edition in 1865). The authors report extensive citations of Mantegazza's original book dealing with sleep hygiene. Mantegazza's indications, compared with Hauri's rules show important similarities. The authors support the view that the fatherhood of sleep hygiene should be acknowledged to Mantegazza and antedated to 1864. Hauri keeps the merit of giving more solid scientific roots to the concept of sleep hygiene and of inserting it in the frame of modern sleep medicine.

Forme di mercato e sistema finanziario. Spunti dalla testimonianza di Sylos Labini alla Commissione parlamentare di inchiesta sui limiti posti alla concorrenza nel campo economico. (Market structure and financial system. Suggestions from Paolo Sylos Labi

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Mario Tonveronachi

2016-04-01

Full Text Available The article builds on the Proceedings of a 1962 Italian Parliamentary enquiry commission on competition, to examine the impact of different market structures on the financial system. The author focuses in particular on the evolution of the banking sector in Italy. Text of the speech given at the conference "Paolo Sylos Labini e la politica delle riforme", held at Sapienza University of Rome on 04 December 2015, organized by the Accademia dei Lincei with Economia Civile. JEL codes: B31, K21, G28 

Postmodernističke parodijske strategije u romanu Epitaf carskog gurmana Veljka Barbijerija

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Dubravka Brunčić

2014-03-01

Full Text Available Strategies of Postmodern Parody in Veljko Barbieri's Novel Epitaph for a Royal Gourmet The article analyzes features of parodic discourse of Barbieri's novel Epitaph of a Royal Gourmet through L. Hutcheon’s theoretical concepts. It explores different parodic subversive strategies (parody of the diary genre, problematizing of the fictionality of historiographic representation, interpolating of gastronomical sublite-rary genres through which ambivalent politics of postmodern representation are manifested in this novel.

Paolo Carta, Il Poeta e la Polis – Colpa e responsabilità in Wystan H. Auden, Padoue, CEDAM, 2003, 170 p., Index des noms, 15 €.

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Marie GAILLE-NIKODIMOV

2005-04-01

Full Text Available Il Poeta e la « Polis » – Colpa e responsabilità in Wystan H. Auden est un livre absolument singulier. Il ne faut pas se fier aux apparences d’un titre qui, pour tout lecteur de Platon, résonne de manière plaisamment familière. Il ne s’agit en rien d’un commentaire de l’exclusion des poètes hors de la cité, évoquée dans l’analyse de la tyrannie au livre VIII de La République. Phénomène inhabituel dans le champ de la réflexion politique, Paolo Carta s’intéresse, en tant qu’historien de la pens...

Can biosemiotics be a "science" if its purpose is to be a bridge between the natural, social and human sciences?

Science.gov (United States)

Brier, Søren

2015-12-01

Central to the attempt to develop a biosemiotics has been the discussion of what it means to be scientific. In Marcello Barbieri's latest argument for leaving Peircean biosemiotics and creating an alternative code-biology the definition of what it means to be scientific plays a major role. For Barbieri "scientific knowledge is obtained by building machine-like models of what we observe in nature". Barbieri interestingly claims that - in combination with the empirical and experimental basis - mechanism is virtually equivalent to the scientific method. The consequences of this statement seem to be that the optimal type of knowledge science can produce about living system is to model them as machines. But the explicit goal of a Peircean semiotically based biosemiotics is (also) to model living systems as cognitive and communicative systems working on the basis of meaning and signification. These two concepts are not part of the mechanistic models of natural science today, not even of cognitive science. Barbieri tries to solve this problem by introducing a new concept of biological meaning that is separate from the Peircean biosemiotics and then add Peirce's semiotics on top. This article argues why this view is inconsistent on the grounds that Peirce's semiotic paradigm only gives meaning in its pragmaticist conception of a fallibilist view of science, which again is intrinsic connected to its non-mechanistic metaphysics of Tychism, Synechism and Agapism. The core of the biosemiotic enterprise is to establish another type of trans- and interdisciplinary wissenschaft than the received view of "science". Copyright © 2015. Published by Elsevier Ltd.

Teste Albumasare cum Sibylla: astrology and the Sibyls in medieval Europe.

Science.gov (United States)

Smoller, Laura Ackerman

2010-06-01

In the 1480s Dominican humanist Filippo de' Barbieri published an illustration of a supposedly ancient female seer called the 'Sybilla Chimica', whose prophetic text repeated the words of the ninth-century astrologer Abu Ma'shar. In tracing the origins of Barbieri's astrological Sibyl, this article examines three sometimes interlocking traditions: the attribution of an ante-diluvian history to the science of the stars, the assertion of astrology's origins in divine revelation, and the belief in the ancient Sibyls' predictions of the birth of Christ and other Christian truths. Medieval authors from the twelfth century on began to cite these traditions together, thereby simultaneously authorizing the use of astrology to predict religious changes and blurring the categories of natural and supernatural as applied to human understanding. This blending of astrology and prophecy appears notably in works by such authors as John of Paris, John of Legnano, Johannes Lichtenberger, and Marsilio Ficino. Ultimately the trajectory that produced Barbieri's astrological Sibyl would lead to a wave of astrological apocalyptic predictions in the sixteenth and seventeenth centuries, as well as to the harnessing of astrology for the defense of the faith in the form of an astrological natural theology, sacralizing science as well as nature.

Giovanni Paolo Marana’s Turkish Spy and the Police of Louis XIV: the Fear of Being Secretly Observed by Trained Agents in Early Modern Europe

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Aleksandra Porada

2014-05-01

Full Text Available Giovanni Paolo Marana’s epistolary novel, entitled l’Espion du Grand-Seigneur and published for the first time in the 1680s, was a pioneering work of a genre that was to flourish much later, namely spy story. The story features an Arab who comes to Paris in 1637 and spends the next 45 years collecting information about French government’s activity without being ever identified by French counter-intelligence. The main character was an undercover agent of a Muslim empire, who watched Christians with contempt - and yet the book that pretended to be just a bunch of his letters, accidentally found and translated from Arabic by Marana, was a bestseller in late seventeenth- and then eighteenth-century Western Europe. The paper presents the fates of the work and discusses the reasons of its huge success. Apart from the fact that the novel was written in a brilliant style, and published at the time when the ongoing Habsburg-Turkish war had triggered intensive interest in the Muslim East, one of these reasons was the fact that it was published in the time when in France a modern police force was created. Its tasks included collecting information about political opinions, religious practices and intimate lives of the Sun King’s subjects. The new feeling of being observed by the government’s men and informers certainly prepared the ground for the success of the first spy story of the West.

Structural studies on a non-toxic homologue of type II RIPs from ...

Indian Academy of Sciences (India)

2015-11-28

Nov 28, 2015 ... bond of a specific adenine in 28 S rRNA (Endo and Tsurugi. 1987; Barbieri et .... model. The structures were refined using Refmac. (Murshudov et al. 1997) from the ...... kine expression in treated spleen cells of rats. Mol. Cell.

Peter Greenaway klaarib kunstiajalooga arveid / Johannes Saar

Index Scriptorium Estoniae

Saar, Johannes, 1965-

2009-01-01

Peter Greenaway multimeediainstallatsioon seeriast "Üheksa klassikalist maali" Paolo Veronese maalist "Kaana pulm" San Giorgio Maggiore kloostris Venezias 6. juunist 13. septembrini. Kloostri söögisaali otsaseinal on Paolo Veronese maali "Kaana pulm" 2007. a. valminud koopia

ALICE honours two Italian suppliers

CERN Multimedia

2006-01-01

From left to right: Robert Terpin (MIPOT), Pier Luigi Bellutti (ITC), Andrea Zanotti, President of ITC, Luciano Bosisio (Trieste University), Gennady Zinovjev (Kiev), Catherine Decosse (CERN), Lodovico Riccati, ALICE Collaboration Board Chair (INFN Torino), Paolo Giubellino (INFN Torino), Mario Zen, Director of ITC, Maurizio Boscardin (ITC), Paolo Tonella (ITC), Jurgen Schukraft, ALICE Spokesperson (CERN), Giacomo Vito Margagliotti (Trieste University), Nevio Grion (INFN Trieste), Marco Bregant (INFN Trieste) Front row from left to right: Paolo Traverso (ITC), Federico Carminati, ALICE Computing Project Leader (CERN), and Jean-Robert Lutz, ITS-SSD Project leader (IPHC Strasbourg).

Comment on ‘An educational path for the magnetic vector potential and its physical implications’

International Nuclear Information System (INIS)

Heras, José A

2014-01-01

In their recent paper, Barbieri et al (2013 Eur. J. Phys. 34 1209) proposed an educational path for the magnetic vector potential. In this comment I point out that this educational path involves several inconsistencies and is therefore unattractive from a pedagogical point of view. (letters and comments)

Reply to Comment on ‘An educational path for the magnetic vector potential and its physical implications’

International Nuclear Information System (INIS)

Barbieri, S; Cavinato, M; Giliberti, M

2014-01-01

In this reply we respond to the comment made by Heras on our paper (Barbieri et al 2013 Eur. J. Phys. 34 1209), in which we presented an educational path on the magnetic vector potential A, aimed at undergraduate students and pre-service physics teachers. (letters and comments)

[Again on language of biology].

Science.gov (United States)

Morchio, di Renzo

2004-01-01

Some time ago I proposed in an Editorial in this journal some considerations on the language of biology. I concluded that, to realize an autonomy of such a language (and therefore of biology), we have to develop a valid language for biology. In such a context, it seemed to me that the term "metaphors" referred to the concepts concerning the information carried by genetic code, was a reasonable one. However, Barbieri's article in this issue of Rivista di Biologia / Biology Forum calls for a reply. Of course, we do not know very much in this field, even if we have some evidence that a sequence of bases on a DNA is not determined only by chance. In any case we can exclude that nature in this occasion has "invented" a code. Nature doesn't "invent" anything: it only follows its rules, that we name "laws of nature". Barbieri quotes the Morse code, but forgets to say that such a code is "conventional" in the sense that it is valid only because it is the result of an "agreement" between Morse and the users of that code. There is nothing more unnatural than a "code": with whom nature should actually have to "reach an agreement"? As a matter of fact, we interpret as "information" what happens by law of nature. Also Barbieri's thesis that genes and proteins are molecular artifacts, assembled by external agents, whereas generally molecules are determined by their bonds, i.e. by internal factors, is a disputable one. It is examined how much an external structure plays a role in ordinary chemical reactions. The "information" of physics is not a semantic information. For such information we can refer to history of literature, telegraphic offices, genetics or biochemistry.

El dintel 3 del templo IV de Tikal : análisis iconográfico y simbólico de la representación /

OpenAIRE

Morselli Barbieri, Simonetta

2013-01-01

 tesis que para obtener el grado de Doctorado en Historia, presenta Simonetta Morselli Barbieri ; tutores principales de tesis Manuel Hermann Lejarazú, Ma. Teresa Uriarte Castañeda, Gerardo Bustos Trejo. 275 páginas : ilustraciones. Doctorado en Historia Universidad Nacional Autónoma de México, 2013 Programa de Posgrado en Historia

Wider than the Sky

Science.gov (United States)

Barbieri, Richard

2015-01-01

More has been learned about the human brain in the past few decades than in the whole prior history of humanity. In this article Richard Barbieri considers learning and the brain from a few different perspectives. He begins by examining the practice of neuroscience itself and what was understood about the brain before neuroscience. This leads to a…

2508-IJBCS-Article-Paolo Lesse

African Journals Online (AJOL)

hp

Il ressort de l'étude que les premiers écrits sur la ... problèmes d'alimentation, de variabilités climatiques, des textes règlementaires, de conflits et de disponibilités .... sud sahélien (Bernus, 1995). ..... les précipitations moyennes globales, il.

La riforma della società per azioni nel pensiero di Sylos Labini e dei suoi contemporanei (Corporate Law Reform in Sylos Labini’s Thought and His Contemporaries’

Directory of Open Access Journals (Sweden)

Mario Stella Richter

2016-06-01

Full Text Available he article describes corporate law in Italy in the Postwar period, as viewed by Paolo Sylos Labini and Tullio Ascarelli. This is the revised version of a speech given at the conference "Paolo Sylos Labini e la politica delle riforme", held at Sapienza University of Rome on 04 December 2015, organized by the Accademia dei Lincei and Economia civile.

Scaling Laws for Heterogeneous Wireless Networks

Science.gov (United States)

2009-09-01

planned and the size of communication networks that are fundamentally understood. On the one hand, wireline networks (like the Internet) have grown from...Franceschetti, Marco D. Migliore, and Paolo Minero . The capacity of wireless networks: Information-theoretic and physical limits. In Proceedings of the...Allerton Conference on Communication, Control, and Computing, September 2007. [12] Massimo Franceschetti, Marco D. Migliore, and Paolo Minero . The

Data of cost-optimal solutions and retrofit design methods for school renovation in a warm climate.

Science.gov (United States)

Zacà, Ilaria; Tornese, Giuliano; Baglivo, Cristina; Congedo, Paolo Maria; D'Agostino, Delia

2016-12-01

"Efficient Solutions and Cost-Optimal Analysis for Existing School Buildings" (Paolo Maria Congedo, Delia D'Agostino, Cristina Baglivo, Giuliano Tornese, Ilaria Zacà) [1] is the paper that refers to this article. It reports the data related to the establishment of several variants of energy efficient retrofit measures selected for two existing school buildings located in the Mediterranean area. In compliance with the cost-optimal analysis described in the Energy Performance of Buildings Directive and its guidelines (EU, Directive, EU 244,) [2], [3], these data are useful for the integration of renewable energy sources and high performance technical systems for school renovation. The data of cost-efficient high performance solutions are provided in tables that are explained within the following sections. The data focus on the describe school refurbishment sector to which European policies and investments are directed. A methodological approach already used in previous studies about new buildings is followed (Baglivo Cristina, Congedo Paolo Maria, D׳Agostino Delia, Zacà Ilaria, 2015; IlariaZacà, Delia D'Agostino, Paolo Maria Congedo, Cristina Baglivo; Baglivo Cristina, Congedo Paolo Maria, D'Agostino Delia, Zacà Ilaria, 2015; Ilaria Zacà, Delia D'Agostino, Paolo Maria Congedo, Cristina Baglivo, 2015; Paolo Maria Congedo, Cristina Baglivo, IlariaZacà, Delia D'Agostino,2015) [4], [5], [6], [7], [8]. The files give the cost-optimal solutions for a kindergarten (REF1) and a nursery (REF2) school located in Sanarica and Squinzano (province of Lecce Southern Italy). The two reference buildings differ for construction period, materials and systems. The eleven tables provided contain data about the localization of the buildings, geometrical features and thermal properties of the envelope, as well as the energy efficiency measures related to walls, windows, heating, cooling, dhw and renewables. Output values of energy consumption, gas emission and costs are given for a

L’etica dell’economista

Directory of Open Access Journals (Sweden)

Alessandro Roncaglia

2016-03-01

Full Text Available The author, following the teachings and example of Paolo Sylos Labini, explores the social role of economists, underling how a useful economist is an ethically committed economist, who pursues the common good. Text of the speech given at the conference "Paolo Sylos Labini e la politica delle riforme", held at Sapienza University of Rome on 04 December 2015, organized by the Accademia dei Lincei with Economia Civile.

La riforma della società per azioni nel pensiero di Sylos Labini e dei suoi contemporanei (Corporate Law Reform in Sylos Labini’s Thought and His Contemporaries’

Directory of Open Access Journals (Sweden)

Mario Stella Richter

2016-07-01

Full Text Available The article describes corporate law in Italy in the Postwar period, as viewed by Paolo Sylos Labini and Tullio Ascarelli.This is the revised version of a speech given at the conference "Paolo Sylos Labini e la politica delle riforme", held at Sapienza University of Rome on 04 December 2015, organized by the Accademia dei Lincei and Economia civile.JEL code: B31; K21; K23

Perché le riforme negli anni sessanta hanno avuto scarso successo: il caso della riforma tributaria. (Why reforms had limited success in the sixties: the case of the tax reform

Directory of Open Access Journals (Sweden)

Antonio Pedone

2016-04-01

Full Text Available The article provides a portrait of Paolo Sylos Labini as a reformer, inspired by the aim to change society through gradual “structural reforms” that reduce inequalities and enlarge freedom.Text of the speech given at the conference "Paolo Sylos Labini e la politica delle riforme", held at Sapienza University of Rome on 04 December 2015, organized by the Accademia dei Lincei with Economia Civile. JEL Codes: H20, B31, N34

L’etica dell’economista (The ethical economist

Directory of Open Access Journals (Sweden)

Alessandro Roncaglia

2016-04-01

Full Text Available The author, following the teachings and example of Paolo Sylos Labini, explores the social role of economists, underling how a useful economist is an ethically committed economist, who pursues the common good. Text of the speech given at the conference "Paolo Sylos Labini e la politica delle riforme", held at Sapienza University of Rome on 04 December 2015, organized by the Accademia dei Lincei with Economia Civile. JEL Codes: A11, A13, B31

ALICE honours two Italian suppliers

CERN Multimedia

2006-01-01

During the ALICE week held in Bologna from 19 to 23 June, the Collaboration recognized two of its top suppliers. From left to right: Robert Terpin (MIPOT), Pier Luigi Bellutti (ITC), Andrea Zanotti, President of ITC, Luciano Bosisio (Trieste University), Gennady Zinovjev (Kiev), Catherine Decosse (CERN), Lodovico Riccati, ALICE Collaboration Board Chair (INFN Torino), Paolo Giubellino (INFN Torino), Mario Zen, Director of ITC, Maurizio Boscardin (ITC), Paolo Tonella (ITC), Jurgen Schukraft, ALICE Spokesperson (CERN), Giacomo Vito Margagliotti (Trieste University), Nevio Grion (INFN Trieste), Marco Bregant (INFN Trieste). Front row from left to right: Paolo Traverso (ITC), Federico Carminati, ALICE Computing Project Leader (CERN), and Jean-Robert Lutz, ITS-SSD Project leader (IPHC Strasbourg). It is in the picturesque city of Bologna that the ALICE Collaboration has rewarded two Italian suppliers, Istituto Trentino di Cultura ITC-irst (Trento) and MIPOT (Cormons), both involved in the construction of the Sili...

Mööbel suvekodusse / Aili Ermel

Index Scriptorium Estoniae

Ermel, Aili

2008-01-01

2008. a. Milano messil "Salone Internazionale del Mobile" oli mööblit, mis projekteeritud ekstra õuele, aga oli ka sellist, mis sobib suvel õue ja talvel tuppa. Mööbel firmalt Cappellini, Gervason (disainer Paola Navone), Horm (disainer Mario Bellini), Zanotta (disainerid Gae Aulenti, Prospero Rasulo, Emaf Progetti, Roberto Barbieri), EMU (disainer Patricia Urquiola), Moroso (disainerid Nipa Doshi, Jonhatan Levien, Edward Van Vliet), Cassina (Tokujin Yoshioka) ja RODA. 14 värv. ill

Sylos Labini: sociologo e meridionalista (Sylos Labini: Sociologist and scholar of the Mezzogiorno

Directory of Open Access Journals (Sweden)

Alessandro Cavalli

2016-04-01

Full Text Available The article focuses on the sociological approach of Paolo Sylos Labini, describing the analysis of the Italian dualism that covers not only the economic but also the social and civic imbalances between North and South of the country. Text of the speech given at the conference "Paolo Sylos Labini e la politica delle riforme", held at Sapienza University of Rome on 04 December 2015, organized by the Accademia dei Lincei with Economia Civile.JEL Codes:  B31, A14, Z13

The French Jesuit Mission to Thailand in the 1680s and the Establishment of a Major Astronomical Observatory

Science.gov (United States)

Soonthornthum, Boonrucksar; Orchiston, Wayne; Komonjinda, Siramas

2012-09-01

The first great Thai ruler to encourage the adoption of Western culture and technology was King Narai, and his enlightened attitude led to the rapid development of Thailand. King Narai also had a passion for astronomy, and he pursued this interest by allowing French Jesuit missionaries to set up a large modern well-equipped astronomical observatory in Lopburi Province between AD 1685 and 1687. This was known as the Wat San Paolo Observatory, and King Narai and the missionaries observed a total lunar eclipse on 10 December 1685 and a partial solar eclipse on 30 April 1688. These observations and others made at Wat San Paolo Observatory during the 1680s marked the start of modern scientific astronomy in Thailand. In this paper we discuss King Narai's scientific and other interests, the founding of the Wat San Paolo Observatory, the missionaries who conducted the astronomical programs, their instruments and their observations. We also describe the surviving ruins of the Observatory and their interpretation as a site of national scientific importance in Thailand.

O estágio emergente das práticas ambientais no desenvolvimento de produto das organizações inovadoras : um estudo exploratório

OpenAIRE

Leandro Jose Morilhas

2007-01-01

A cada dia, a preocupação ambiental torna-se mais relevante no contexto empresarial, seja por meio de pressões de consumidores, governos, ONGs, entre outros, devendo estar presente em todas as ações, processos e procedimentos organizacionais, dentre estes o de desenvolvimento de produtos. Considerando que tal processo envolve de modo geral, às áreas de marketing, engenharia e manufatura, este trabalho, a partir de conceitos de gestão ambiental apresentados por Barbieri (2006), Tachizawa (2005...

Volumi di Paolo Sommaiolo e Annamaria Sapienza

DEFF Research Database (Denmark)

Chemi, Tatiana

1999-01-01

Review of the volume by P.S. on the Music-Hall productions in Naples during the XIX and XX century; review of the volume by A.S. on the mechanisms of parody in the XIX century Italian opera.......Review of the volume by P.S. on the Music-Hall productions in Naples during the XIX and XX century; review of the volume by A.S. on the mechanisms of parody in the XIX century Italian opera....

Sem dança não tem força nenhuma: Creating indigenous spaces in São Paulo urban area

Directory of Open Access Journals (Sweden)

Sofia Venturoli

2016-08-01

Full Text Available L’articolo presenta alcune tappe fondamentali, politiche e culturali, del processo di formazione dell’associazione indigena Pankararé a San Paolo, Brasile. L’articolo si svolge attraverso le parole di uno dei protagonisti della costruzione del nucleo urbano Pankararé, la leader della associazione Alaìde Pereira Xavier Feitosa. Il racconto di Alaide si muove tra la zona urbana di San Paolo e la terra d’origine situata nello stato di Bahia, per ripercorrere il cammino di costruzione di spazi indigeni e rivendicazioni di cittadinanza differenziata che definiscono la loro legittimità nei percorsi della memoria e nelle pratiche rituali.

L’attualità di Bruno de Finetti nella crisi in corso dell’economia e della teoria economica

Directory of Open Access Journals (Sweden)

Felice Roberto Pizzuti

2016-10-01

Full Text Available (A note on the contributions by Augusto Graziani and Paolo Sylos Labini on the endogenous nature of money supplyThe article compares the analyses of money supply by Augusto Graziani and Paolo Sylos Labini. Both authors criticised neoclassical monetary theory highlighting the endogenous nature of money supply. However, they explained the sources of money supply differently, in view of their different approach towards the Classical, heterodox neoclassical and Keynesian traditions. The analysis of both authors' works highlights the fecundity of a stage in Italy's economic thought that would seed into several promising developments.JEL Classification: H55, D64, B31

Inovações sustentáveis e vantagem competitiva : um estudo qualitativo no setor hoteleiro em Fortaleza-CE

OpenAIRE

Cardoso, Márcia Lopes

2014-01-01

A presente pesquisa tem por objetivo analisar como a adoção de inovações visando à sustentabilidade influencia a obtenção de vantagem competitiva das empresas do setor hoteleiro de Fortaleza. Para a construção do arcabouço teórico foram utilizados autores clássicos, como Barbieri, Gallouj, Porter, Schumpeter, Tidd, Bessant e Pavitt, entre outros; e periódicos internacionais atuais. O estudo adotou o modelo conceitual proposto Chen, Lai e Wen (2006) e Hansen, Grosse-Dunker e...

Pedestrian Inattention Blindness While Playing Pokémon Go as an Emerging Health-Risk Behavior: A Case Report.

Science.gov (United States)

Barbieri, Stefania; Vettore, Gianna; Pietrantonio, Vincenzo; Snenghi, Rossella; Tredese, Alberto; Bergamini, Mauro; Previato, Sara; Stefanati, Armando; Gaudio, Rosa Maria; Feltracco, Paolo

2017-04-01

positive and negative effects of video games, which are becoming a source of public health concern. Health care providers should be aware of their chief role in these possible prevention strategies, based on their direct interactions with road incident victims. ©Stefania Barbieri, Gianna Vettore, Vincenzo Pietrantonio, Rossella Snenghi, Alberto Tredese, Mauro Bergamini, Sara Previato, Armando Stefanati, Rosa Maria Gaudio, Paolo Feltracco. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 01.04.2017.

Greenaway Kaana pulmas / Jaan Elken

Index Scriptorium Estoniae

Elken, Jaan, 1954-

2009-01-01

Peter Greenaway Paolo Veronese maalist "Kaana pulm" tehtud visioonist San Giorgio Maggiore kloostris Venezias ja Peter Greenaway esinemisest 3. 06. Projekti demonstreeriti sünkroonselt 53. Veneetsia biennaaliga

77 FR 61755 - Performance Review Board Members

Science.gov (United States)

2012-10-11

... JULIET COHEN GARY CONNOR SUZI COX VIRGINIA DANIEL KATHERINE DEL VECCHIO PAOLO DELPHIN-RITTMON MIRIAM DEVOSS ELIZABETH DICKINSON ELIZABETH ERNEY JOAN GABRIEL EDWARD GOLDHABER BEN GOTTLICH VICKI HENDERSON...

Paolo Sylos Labini: Reflections of a Classical Economist

Directory of Open Access Journals (Sweden)

Giulia Zacchia

2016-06-01

Full Text Available The article provides a review of Sylos Labini’s memories, collected here on occasion of the tenth anniversary of his passing away. The author reports on the proceedings of two conferences in memory of Sylos Labini held in Rome, on 18 November 2015 at the Lincean Academy and on 4 December 2015 at Sapienza University. Sylos Labini stipulated that the goal of economic development is not just to satisfy human needs, but to cater civil development itself, in accordance with Adam Smith’s fundamental lesson. In his view, economic development and civil development interact in a circular manner in the long run. Considering the developmental issues of Italy’s Mezzogiorno, Sylos Labini highlights that the nature of the problem is not only economic, but rather many issues arise from unreasonable links between politics, economy, and society. Accordingly, he provided policy suggestions that are not limited to the economic and industrial fields (such as water supply projects, irrigation infrastructures, and investments for the creation of modern industries, but he also identified three priority areas of social policy: measures to contrast the mafias, crime in public procurement, and corruption; a reform of the public administration; and investments in education, universities, and research. JEL: B31; A11; N14; A12

Donato D'Urbino

Index Scriptorium Estoniae

2005-01-01

Itaalia arhitektide-disainerite Jonathan De Pasi, Donato D'Urbino, Paolo Lomazzi ja Carla Scolari kavandatud ning Itaalia firmas Zanotta S.p.A. toodetud täispuhutavast plastikust tugitoolist "Blow" (1967)

B-decay anomalies in Pati-Salam SU(4)

Science.gov (United States)

Barbieri, Riccardo; Tesi, Andrea

2018-03-01

Attempts to incorporate in a coherent picture the B-decay anomalies presumably observed in b→ c and b→ s semi-leptonic decays have to face the absence of signals in other related experiments, both at low and at high energies. By extending and making more precise the content of Barbieri et al. (Eur Phys J C 77(1):8, 2017), we describe one such attempt based on the Pati-Salam SU(4) group, that unifies colour and the B- L charge, in the context of a new strongly interacting sector, equally responsible for producing a pseudo-Goldstone Higgs boson.

Bound-state perturbation theory and annihilation effects in positronium

International Nuclear Information System (INIS)

Abbasabadi, A.; Repko, W.W.

1987-01-01

Working in Coulomb gauge and using the lowest-order equation proposed by Barbieri and Remiddi it is calculated, in the one-loop order of perturbation theory, the decay rate and the energy shift of the ground states of parapositronium and orthopositronium, respectively. Our result for the decay rate agrees with that of Harris and Brown. For contribution of one-photon-annihilation channel to the energy shift, it is confirmed the result of Karplus and Klein. These results are derived completely within the bound-state formalism and avoid the necessity of performing on-mass-shell wave function and vertex renormalization subtractions

Pronto chi parla. Cesare e le intercettazioni telefoniche

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Paolo Caponi

2010-03-01

Full Text Available Pronto chi parla. Cesare e le intercettazioni telefoniche (Ugo Guspini, L’orecchio del regime. Le intercettazioni telefoniche al tempo del fascismo, Milano, Mursia, 1973, pp. 262 di Paolo Caponi

Veneetsia biennaali uued juhid / Maria-Kristiina Soomre

Index Scriptorium Estoniae

Soomre, Maria-Kristiina, 1978-

2002-01-01

Veneetsia biennaali senine president Paolo Barratta ja biennaali komitee astusid tagasi. Uueks biennaali presidendiks on määratud Franco Bernabe. 2003. a. kunstibiennali eest vastutavaks saab ilmselt kunstikriitik Robert Hughes (s. 1938 Austraalias)

Maria Rizzarelli, Una terra che è solo visione. La poesia di Pasolini tra cinema e pittura

Directory of Open Access Journals (Sweden)

Paolo Lago

2016-11-01

Full Text Available La contaminazione tra scrittura e visione, la «natura anfibologica» tra parola e immagine, secondo una definizione dello stesso autore, risulta fondamentale nell’intera opera letteraria di Pier Paolo Pasolini.

Interaction and Mindreading

DEFF Research Database (Denmark)

Michael, John Andrew

2011-01-01

In recent years, a number of theorists have developed approaches to social cognition that highlight the centrality of social interaction as opposed to mindreading (e.g. Gallagher and Zahavi 2008; Gallagher 2001, 2007, 2008; Hobson 2002; Reddy 2008; Hutto 2004; De Jaegher 2009; De Jaegher and Di...... Paolo 2007; Fuchs and De Jaegher 2009; De Jaegher, Di Paolo and Gallagher 2010). There are important differences among these approaches, as I will discuss, but they are united by their commitment to the claim that various embodied and extended processes sustain social understanding and interaction...... will give reasons for being skeptical about. I will then present an alternative and moderate version of interactionism, according to which the embodied and extended processes that interactionists emphasize actually complement mindreading and may even contribute as an input to mindreading....

Pasolini fifty years ago: «Mi è tornata la fantasia del narratore»

Directory of Open Access Journals (Sweden)

Alfredo Barberis

2014-05-01

Full Text Available An interview with Pier Paolo Pasolini by Alfredo Barberi, published by «il Giorno» in 1964 and since then only republished once in a now exrtemely rare collection by Oronzo Panageli.

De syv kirker

DEFF Research Database (Denmark)

Bekker-Nielsen, Tønnes

2000-01-01

Siden renæssancen har det været skik, at pilgrimme til Rom foretager vandringen rundt til de "syv kirker": Peterskirken, S. Paolo, S. Sebastiano, Laterankirken, S. Maria Maggiore, S. Croce og S. Lorenzo....

Ilu: ülendav, paheline, hirmutav / Jaan Ruus, Viive Ruus

Index Scriptorium Estoniae

Ruus, Jaan, 1938-2017

2015-01-01

Vastukaja Aurelia Aasa arvustusele ("Idülliline lugu kahetsusest ja igatsusest", Sirp, 9. okt., 2015) filmile "Noorus", režissöör ja stsenarist Paolo Sorrentino. "Noorus" kui järg filmile "Kohutav ilu"

Reconfortante historia de las luchas laborales en los puertos del Caribe colombiano

Directory of Open Access Journals (Sweden)

Renán Vega Cantor

2005-05-01

Full Text Available Puertos, sociedad y conflicto en el Caribe colombiano, 1850-1930. Sergio Paolo Solano de las Aguas. Observatorio del Caribe Colombiano, Ministerio de Cultura, Universidad de Cartagena, Bogotá, 2003, 116 págs.

Pärnu saab esimese kõrghoone?

Index Scriptorium Estoniae

2006-01-01

Pärnu kesklinna jõeäärse ala rahvusvahelise arhitektuurikonkursi võidutöö "Flood", mille autoriteks on itaalia arhitektid Francesco De Luca, Paolo Gori, Romolo Nati, Antonio Capasso ja Giuliana Mancinelli Bonafaccia. Ill.: 3 vaadet

Pärnu polutshit pervoje võsotnoje zdanije?

Index Scriptorium Estoniae

2006-01-01

Pärnu kesklinna jõeäärse ala rahvusvahelise arhitektuurikonkursi võidutöö "Flood", mille autoriteks on itaalia arhitektid Francesco De Luca, Paolo Gori, Romolo Nati, Antonio Capasso ja Giuliana Mancinelli Bonafaccia. Ill.: 3 vaadet

Toward a Better Implementation of the Audio-Lingual Approach

Science.gov (United States)

Valdman, Albert

1970-01-01

Revised version of a paper presented at the Fifth Symposium of the PILEI, Programa Interamericano de Linguistica y Ensenanza de Idiomas (Inter-American Program on Linguistics and Foreign Language Instruction), Sao Paolo, Brazil, January 11, 1969. (DS)

Interpolating Polynomial Macro-Elements with Tension Properties

Science.gov (United States)

2000-01-01

Univ. Calgary, 1978. Paolo Costantini Dipartimento di Matematica " Roberto Magari" Via del Capitano 15 53100 Siena, Italy costantini~unisi. it Carla...Manni Dipartimento di Matematica Via Carlo Alberto 10 10123 Torino, Italy manniDdm .unito. it

Jugando a jugar

Directory of Open Access Journals (Sweden)

Andrés García Londoño

2000-01-01

Full Text Available El pan y el circo. La experiencia lúdica en una sociedad de mercado. Paolo Vignolo. Instituto Distrital de Cultura y Turismo-Tercer Mundo Editores. Sanrafé de Bogotá, 1997, 212 págs.

Pärnu südalinna kavandatakse 17-korruselist uhket ärikeskust / Kristjan Jõevere

Index Scriptorium Estoniae

Jõevere, Kristjan

2006-01-01

Pärnu südalinna planeerimise ideekonkursi võitis töö "Flood", autorid eesti ja itaalia arhitektid Francesco De Luca, Paolo Gori, Romolo Nati, Mauro Olevano, Kerttu Koll, Antonio Capasso, Giuliana Mancinelli Bonafaccia ja Helen Sooväli

Camillo Faverzani (éditeur), Part[h]enope. Naples et les arts / Napoli ...

African Journals Online (AJOL)

User

arte e della storia hanno il loro teatro di elezione, è facile pronosticare al mito di Partenope, affascinante e ingombrante, attraente e irritante, un lungo futuro. Franco Arato. (Università di Torino). Paolo Sortino, Elisabeth, Torino, Einaudi, 2011, ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences. VINCENZO IERARDI. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 623-636 Article. Klebsiella pneumoniae antibiotic resistance identified by atomic force microscopy · VINCENZO IERARDI PAOLO DOMENICHINI SILVIA REALI GIAN MARCO ...

Cooperation-Induced Topological Complexity: A Promising Road to Fault Tolerance and Hebbian Learning

Science.gov (United States)

2012-03-16

Information Science Directorate, United States Army Research Office, Durham, NC, USA 4 Istituto di Fisiologia Clinica del Consiglio Nazionale delle...Vadim Uritsky, Catholic University of America at NASA Goddard Space Flight Center, USA *Correspondence: Paolo Allegrini , Istituto di Fisiologia Clinica

Tulev aasta toob kaheksanda "Baltoscandali" / M. T.

Index Scriptorium Estoniae

M. T.

2005-01-01

8.-9. dets. on Rakvere teatris Johan Simonsi lavastus "Hääled" mille autor on Pier Paolo Pasolini. Neljas rollis belgia-hollandi näitleja Jeroen Willems. Samadel päevadel on Rakveres 28.06.-2.07.2006 toimuva teatrifestivali tutvustus

General background and approach to multibody dynamics for space applications

Science.gov (United States)

Santini, Paolo; Gasbarri, Paolo

2009-06-01

Multibody dynamics for space applications is dictated by space environment such as space-varying gravity forces, orbital and attitude perturbations, control forces if any. Several methods and formulations devoted to the modeling of flexible bodies undergoing large overall motions were developed in recent years. Most of these different formulations were aimed to face one of the main problems concerning the analysis of spacecraft dynamics namely the reduction of computer simulation time. By virtue of this, the use of symbolic manipulation, recursive formulation and parallel processing algorithms were proposed. All these approaches fall into two categories, the one based on Newton/Euler methods and the one based on Lagrangian methods; both of them have their advantages and disadvantages although in general, Newtonian approaches lend to a better understanding of the physics of problems and in particular of the magnitude of the reactions and of the corresponding structural stresses. Another important issue which must be addressed carefully in multibody space dynamics is relevant to a correct choice of kinematics variables. In fact, when dealing with flexible multibody system the resulting equations include two different types of state variables, the ones associated with large (rigid) displacements and the ones associated with elastic deformations. These two sets of variables have generally two different time scales if we think of the attitude motion of a satellite whose period of oscillation, due to the gravity gradient effects, is of the same order of magnitude as the orbital period, which is much bigger than the one associated with the structural vibration of the satellite itself. Therefore, the numerical integration of the equations of the system represents a challenging problem. This was the abstract and some of the arguments that Professor Paolo Santini intended to present for the Breakwell Lecture; unfortunately a deadly disease attacked him and shortly took him

Proceedings of the Nautical Almanac Office Sesquicentennial Symposium Held in Washington, The District of Columbia on March 3-4, 1999

Science.gov (United States)

1999-03-01

This is not quite true, for the fifteenth-century Florentine astrono - mer Paolo Toscanelli recorded the night-to-night positions of several comets on...enormously successful Astrono - mische Nachrichten. Later in the nineteenth century, particularly with the development of telegraphic communication, more rapid

A new approach to Franciscan political thought

Directory of Open Access Journals (Sweden)

Roberto Lambertini

2010-06-01

Full Text Available This essay debates Paolo Evangelisti’s book, and emphasizes – in comparison with the opinions of Ovidio Capitani and Giacomo Todeschini – his political approach to the reasoning of the Franciscans about the State building in kingdom of Aragon.

Overexpression of gamma-tubulin in non small cell lung cancer

Czech Academy of Sciences Publication Activity Database

Maounis, N.; Mahera, E.; Dráberová, Eduarda; Chorti, M.; Riga, D.; Trakas, N.; Demonakou, M.; Emmanouilidou, A.; Dráber, Pavel; Katsetos, C.D.

2010-01-01

Roč. 57, č. 1 (2010), s. 227-227 ISSN 0309-0167. [International Congress of the International Academy of Pathology /28./. 10.10.10.-15.10.10, San Paolo] Institutional research plan: CEZ:AV0Z50520514 Subject RIV: EB - Genetics ; Molecular Biology

From Self-Organized to Extended Criticality

Science.gov (United States)

2012-04-26

Texas, Denton, TX, USA 2 Centro EXTREME, Scuola Superiore Sant’Anna, Pisa, Italy 3 Istituto di Fisiologia Clinica-CNR, Pisa, Italy 4 Department of Physics...Netherlands Klaus Linkenkaer-Hansen, Center for Neurogenomics and Cognitive Research, Netherlands *Correspondence: Paolo Allegrini , Istituto di Fisiologia

Mari Koger : avatud magamistoaga korter pööningukorrusel / Gitte Hint

Index Scriptorium Estoniae

Hint, Gitte

2003-01-01

Korter Nõmmel renoveeritud puumajas (arhitekt Hannes Niineväli). Sisearhitekt Mari Koger, tema kommentaarid. Söögilaua alumiiniumist valatud jalgade autor on Taavi Aunre. Söögilauda valgustab Alberto Meda ja Paolo Rizzatto disainitud lamp Titania. Ill.: plaan, 8 värv. vaadet

Sugli studi medievali e il mutamento digitale On the medieval studies and the digital change

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Redazione Reti Medievali (a cura di

2004-12-01

Full Text Available

La sezione raccoglie tre brevi comunicazioni, tenute nell’ambito del seminario Medium-Evo. Gli studi medievali e il mutamento digitale (Firenze, 2001 e dedicate rispettivamente ai periodici e alle forme di comunicazione del sapere (Giorgio Chittolini, al problema del reperimento delle risorse e della repertoriazione delle fonti (Paolo Delogu, ai contraccolpi dell’uso del mezzo informatico sulla scrittura della storia (Giuseppe Sergi.

This section includes three short papers - presented at the seminar on Medium-Evo. Gli studi medievali e il mutamento digitale (Firenze, 2001 (Medium-Evo. Medieval studies and the digital change - which are respectively focused on periodicals, different types of learning communication (Giorgio Chittolini, problems linked to document searching and filing (Paolo Delogu, backlashes  coming from the use of computer in writing history (Giuseppe Sergi.

Networks in Cell Biology

Science.gov (United States)

Buchanan, Mark; Caldarelli, Guido; De Los Rios, Paolo; Rao, Francesco; Vendruscolo, Michele

2010-05-01

Introduction; 1. Network views of the cell Paolo De Los Rios and Michele Vendruscolo; 2. Transcriptional regulatory networks Sarath Chandra Janga and M. Madan Babu; 3. Transcription factors and gene regulatory networks Matteo Brilli, Elissa Calistri and Pietro Lió; 4. Experimental methods for protein interaction identification Peter Uetz, Björn Titz, Seesandra V. Rajagopala and Gerard Cagney; 5. Modeling protein interaction networks Francesco Rao; 6. Dynamics and evolution of metabolic networks Daniel Segré; 7. Hierarchical modularity in biological networks: the case of metabolic networks Erzsébet Ravasz Regan; 8. Signalling networks Gian Paolo Rossini; Appendix 1. Complex networks: from local to global properties D. Garlaschelli and G. Caldarelli; Appendix 2. Modelling the local structure of networks D. Garlaschelli and G. Caldarelli; Appendix 3. Higher-order topological properties S. Ahnert, T. Fink and G. Caldarelli; Appendix 4. Elementary mathematical concepts A. Gabrielli and G. Caldarelli; References.

La ‘scrittura del caso’ come strategia di ricerca per le professioni educative

Directory of Open Access Journals (Sweden)

Elisabetta Biffi

2014-12-01

Full Text Available The current paper explores the practice of case writing in educational and pedagogical work, focusing on its use by education professionals as a research and self-reflective strategy. This analysis of the pedagogical case write-up (Riva, 2007 as a clinical research procedure (Demetrio, 2008 is theoretically informed by the hermeneutic phenomenological approach (Van Manen, 1990; 2002 and by the psychoanalytical tradition of clinical case writing (Barbieri, 2005; Ferro, 1999; Semi, 1992. Both approaches provide valuable resources for professionals engaging in case writing, a practice that requires a research stance and a reflective and critical outlook, including and indeed all the more so when it involves telling educational stories.

Academic Training: 2004 - 2005 ACADEMIC TRAINING PROGRAMME

CERN Multimedia

Françoise Benz

2004-01-01

1st Term - 01 October to 17 December 2004 REGULAR LECTURE PROGRAMME New Trends in Fusion Research by A. Fasoli, EPFL, Lausanne, CH 11, 12, 13 October Physics at e+e- linear collider by K. Desch, DESY, Hamburg, D 15, 16, 17, 18, 19 November LECTURE SERIES FOR POSTGRADUATE STUDENTS Standard Model by R. Barbieri, CERN-PH-TH 6, 7, 8, 9 10 December The lectures are open to all those interested, without application. The abstract of the lectures, as well as any change to the above information (title, dates, time, place etc) will be published in the CERN Bulletin, the WWW, and by notices before each term and for each series of lectures.

Simple simulation schemes for CIR and Wishart processes

DEFF Research Database (Denmark)

Pisani, Camilla

2013-01-01

We develop some simple simulation algorithms for CIR and Wishart processes. The main idea is the splitting of their generator into the sum of the square of an Ornstein-Uhlenbeck matrix process and a deterministic process. Joint work with Paolo Baldi, Tor Vergata University, Rome...

supp4.doc

Indian Academy of Sciences (India)

Naresh Duvva,a Ravi Kumar Kanaparthi,a Jaipal Kandhadi,a Gabriele Marotta,b Paolo Salvatori,b Filippo De Angelis,*b Lingamallu Giribabu*a. aInorganic & Physical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500607, India. bComputational Laboratory for Hybrid/Organic Photovoltaics ...

The relational model is dead, SQL is dead, and i don't feel so good myself

DEFF Research Database (Denmark)

Atzeni, Paolo; Jensen, Christian S .; Orsi, Giorgio

2013-01-01

on Conceptual Modeling. The panelists include: Paolo Atzeni (Università Roma Tre, Italy), Umeshwar Dayal (HP Labs, USA), Christian S. Jensen (Aarhus University, Denmark), and Sudha Ram (University of Arizona, USA). Quotations from movies are used as a playful though effective way to convey the dramatic changes...

Os imigrantes italianos em São Paulo, na perspectiva de Alcântara Machado

Directory of Open Access Journals (Sweden)

Vera Lúcia de Oliveira

2004-12-01

Full Text Available Il libro Brás, Bexiga e Barra Funda, di Alcântara Machado, pubblicato nel 1927, tratta della vit di alcuni quartieri poplari di San Paolo (indicati nel titolo dell´opera, obitari da immigranti italiani. Il narratore rappresenta questo universo - ora con simpatia ora con ironia - rivelando, in modo chiaro o tra le righe, gli sterotipi in voga in quel periodo sugli italiani arrivati da poco, che non conoscevano ancora la lingua e le tradizioni del Brasile, ma desideravano raggiungere rapidamente una posizione social ed economica elevata, per conquistare un posto nella nuova società. Nell´articolo si propone una lettura dello scontro fra gli immigranti e la società brasiliana, scontro filtrato nei racconti che presentano - con straordinaria vivacità - il quotidiano dei quartieri popolari di San Paolo, proprio nel momento in cui vari gruppi di immigranti stanno vivendo il processo di integrazione e assimilazione.

ALICE physicists receive 2014 Lise Meitner Prize

CERN Multimedia

Jeanneret, Guillaume

2014-01-01

September 3rd, 2014: ALICE collaboration members Johanna Stachel (Heidelberg University, Germany), Peter Braun-Munzinger (GSI, Germany), Paolo Giubellino (INFN Turin, Italy, and CERN) and Jürgen Schukraft (CERN) were presented the 2014 Lise Meitner Prize at a private ceremony held in the Globe of Science and Innovation.

Meta 2: Lingua Franca Design and Integration Language

Science.gov (United States)

2011-08-01

Banca Intesa/San Paolo. He was the founder and Scientific Director of the Project on Advanced Research on Architectures and Design of Electronic...34Platform-Based Design and Frameworks: Metropolis and Metro II" in Model-Based Design for Embedded Systems, Boca Raton, Fl: CRC Press , Taylor and

Health education as education of the oppressed

Directory of Open Access Journals (Sweden)

NC van Wyk

1999-09-01

Full Text Available Paolo Freire’s theory of critical thinking shows remarkable similarities to the principles supported by health education. In his capacity as Brazilian educationalist, Freire emphasized man’s active participation in his own development. Without this active involvement, growth and development become quite impossible to attain.

A critical analysis of Pier Paolo Pasolini’s African Oresteia

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K. Michaelis

1996-04-01

Full Text Available Pasolini's Appunti per un’Orestiade africana (1970 is a metaphorical film, inspired by the Greek legend of Orestes, in which Pasolini views postcolonial African history through the lens of mythology. His portrait of the birth of “modern” Africa is an attempt to narrate the passage from past to present and to salvage "prehistory" through his dream of the unification of the rational, democratic state and the irrational, primal slate of being. It is, however, a dream punctuated by contradictions and paradoxes, a dream which Pasolini will later abandon. Yet it is significant in the overall development of Pasolini's genre.

Academic Training: 2004 - 2005 ACADEMIC TRAINING PROGRAMME

CERN Multimedia

Françoise Benz

2004-01-01

1st Term - 01 October to 17 December 2004 REGULAR LECTURE PROGRAMME New Trends in Fusion Research by A. Fasoli, EPFL, Lausanne, CH 11, 12, 13 October Physics at e+e- linear collider by K. Desch, DESY, Hamburg, D 15, 16, 17, 18, 19 November LECTURE SERIES FOR POSTGRADUATE STUDENTS Standard Model by R. Barbieri, CERN-PH-TH 6, 7, 8, 9 10 December The lectures are open to all those interested, without application. The abstract of the lectures, as well as any change to the above information (title, dates, time, place etc) will be published in the CERN Bulletin, the WWW, and by notices before each term and for each series of lectures. ENSEIGNEMENT ACADEMIQUE ACADEMIC TRAINING Françoise Benz 73127 academic.training@cern.ch

Pop & rock, Retro, Etno, Jazz / Lauri Sommer

Index Scriptorium Estoniae

Sommer, Lauri, 1973-

2001-01-01

John Frusciante heliplaadi To Record Only Water in Ten Days, Titiyo heliplaadi Come Along, Alizee heliplaadi Gourmandises, Mati Nuude heliplaadi Parimad I/II, Filmi "For Love Or Country" soundtrack-albumi, ansambli Cabaret Voltaire heliplaadi Remixed, Paolo Fresu heliplaadi Sonos' E Memoria, Michael Mantleri heliplaadi Hide and Seek lühitutvustus

Capability through Participatory Democracy: Sen, Freire, and Dewey

Science.gov (United States)

Glassman, Michael; Patton, Rikki

2014-01-01

This paper explores possible important relationships and sympathies between Amartya Sen's Capabilities Approach framework for understanding the human condition and the educational ideas of John Dewey and Paolo Freire. All three focus on the importance of democratic values in a fair, well-functioning society, while Sen and Freire especially…

Baltoscandal tuleb "Häältega" / Inna Grünfeldt

Index Scriptorium Estoniae

Grünfeldt, Inna, 1961-

2005-01-01

8.-9. dets. on Rakvere teatris Johan Simonsi lavastus "Hääled" mille autor on Itaalia režissöör ja kirjanik Pier Paolo Pasolini. Neljas rollis belgia-hollandi näitleja Jeroen Willems. Samadel päevadel oli Rakveres 28.06.-2.07.2006 toimuva teatrifestivali tutvustus

"Luce profuga" di Valerio Aioli e "La badante". "Un amore ...

African Journals Online (AJOL)

The novels Luce profuga by Valerio Aiolli (2001) and La badante. Un amore volontario by Paolo Teobaldi (2004) are exceptions because they present migrants in a positive way and show that it is possible for some Italians to overcome their prejudices towards foreigners, and that the encounter with alterity can have positive ...

Multimodal Integration of High Resolution EEG and Functional Magnetic Resonance: a Simulation Study

Science.gov (United States)

2001-10-25

Luca Romani3, Paolo Maria Rossini2, and Febo Cincotti4 1 Dip. Fisiologia umana e Farmacologia, Università "La Sapienza", Rome, 2 “AFAR", Ospedale...Organization Name(s) and Address(es) Dip. Fisiologia umana e Farmacologia, Università "La Sapienza", Rome Performing Organization Report Number Sponsoring

Summer Conference on General Topology and Applications (10th) Held in Amsterdam on 15-18 August 1994

Science.gov (United States)

1994-08-18

topology. Joint work by: I. Juhisz and Z. Szentmiid6ssy. Room: KC1.37 Time: TUE 16:40-1 7:00 ABSTRACTS 89 Forcing and Normality, II LUcia R. Junqueira...Gerard A. Venema (Calvin College, Grand Rapids, MI, USA) J. Vermeer (TU Delft, Delft, the Netherlands) Paolo Vitolo (Universita della Basilicata, Potenza

The Identity of Discord: The Paradoxical Discourse of Sperone ...

African Journals Online (AJOL)

L'umanista padovano Sperone Speroni (1500-1588) scrisse il Dialogo della discordia tra il 1537 e il 1540 e lo incluse nella sua prima edizione dei Dialoghi, pubblicata a Venezia nel 1542 da Paolo Manuzio. In quest'opera Speroni critica la natura stessa della ricerca epistemologica e fenomenologica. Come si dimostra in ...

The reformer, the prince, and the infidel, between Aragon and Silesia (XIV-XV Centuries

Directory of Open Access Journals (Sweden)

Ludovic Viallet

2010-06-01

Full Text Available On the ground of Paolo Evangelisti’s book, this essay dwells upon the use of the some concepts (e.g., the ideas of Passio Christi and Mistical Body, of reform, regarding social control and identity symbols, and of the sacred, in the context of the Franciscan thought about the State building.

Filmens migrasjon til en digital plattform

DEFF Research Database (Denmark)

Fetveit, Arild

2011-01-01

in The Virtual Life of Film, and Paolo Cherchi Usai in The Death of Cinema, the article comments on entries in the debate from Henry Jenkins, Noël Carroll, John Bolton, Stephen Prince, Tom Gunning and others. The article argues in favor of a multi-dimensional concept of “film”. It rejects the idea...

Conmemoración de Charles Darwin (1882

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Paolo Mantegazza

2014-07-01

Full Text Available Tres semanas después de la muerte del biólogo y naturalista inglés, Paolo Mantegazza pronunció el 21 de mayo de 1882 su "Conmemoración de Charles Darwin celebrada en el Real Instituto de Estudios Superiores en Florencia". Traducción de Juan Pérez Andrés.

La costruzione e la decorazione della Sala Maria Luigia nella Biblioteca Palatina di Parma

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Maria Carla Ramazzini Calciolari

2011-01-01

Full Text Available Si ripercorre la storia di una commissione pubblica, la nuova sala della Biblioteca Palatina di Parma, cercando di ricostruire i rapporti intercorsi tra il Bibliotecario Pezzana, l'architetto di Corte Nicolò Bettoli e il Direttore dell'Accademia di Belle Arti Paolo Toschi, e di individuare i modelli culturali, architettonici ed artistici di riferimento.

A new intelligent approach for air traffic control using gravitational ...

Indian Academy of Sciences (India)

Therefore, poor management of this congestion may lead to a lot of flight delays, increase of operational errors by air traffic control personnel ... the PLT [8–11], and decreasing the duration of scheduling. [12, 13]. Hansen [3], Hu ...... [14] Hu X-B and Paolo E D 2009 An efficient genetic algorithm with uniform crossover for air ...

Veils, Caps and Hats: The Language of Headgear between the ...

African Journals Online (AJOL)

L'autrice tratta l'uso del copricapo nel Medievo e all'inizio dell'Età moderna, con continui riferimenti ai testi di San Paolo e alle prediche quattrocentesche dei frati minori dell'osservanza francescana. Viene altresì considerato l'impiego della mantellina, del velo e del piumaggio, tipiche della moda del tempo, in relazione alle ...

A new high-altitude species of centipede from the Andes of Ecuador (Chilopoda, Geophilomorpha, Schendylidae).

Science.gov (United States)

Pereira, Luis Alberto

2018-01-18

Pectiniunguis aequatorialis sp. nov. (Chilopoda: Geophilomorpha: Schendylidae) is described and illustrated on the basis of specimens collected in the Cayambe-Coca Ecological Reserve in the High Andes of Ecuador. The new species is characterized by having ventral pore-fields on the anterior region of the trunk only, a trait that is shared by a single Neotropical congener: Pectiniunguis ascendens Pereira, Minelli Barbieri, 1994 to which it is similar and is compared taxonomically. This is only the second report of a species of the genus Pectiniunguis Bollman, 1889 from mainland Ecuador. The other taxon is Pectiniunguis roigi Pereira, Foddai Minelli, 2001, so far only known from the type locality, Limoncocha (Sucumbíos Province), and herein reported for the first time from Parque Nacional Sumaco Napo-Galeras (Napo Province).

The image of the city Sao Paolo – identity and crisis

Directory of Open Access Journals (Sweden)

Roberto Rocco

2003-01-01

Full Text Available Although Brazil is renowned worldwide for its fascinating 20th century modernist architecture, the ongoing contemporary architecture is increasingly moving away from former avant-garde and cosmopolitan ideals as well as physical form. In São Paulo, the country’s largest city, high quality and typical architectural design has been crumbling before the onslaught of poorly articulated consumer demands and the property market for decades. The phenomenon of the neoclassical style is causing increasing revolt from representatives of the urban elite, the reasons being loss of aesthetic values, no knowledge of identity and hurt national pride.

Panorama dell´italiano in San Paolo nel contesto plurilinguistico brasiliano

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Loredana de Stauber Caprara

2004-12-01

Full Text Available O italiano, ou variedades dialetizadas de italiano, no início do século XX era falado aproximadamente pela metade da população de São Paulo. Posteriormente, por diferentes motivos, entre os quais a chegada de outros grupos étinicos e diminuição progressiva de onda imigratória italiana, essa porcentagem diminuiu muito. Agora, quase quarenta anos após o fim do movimento imigratório, a permanência do italiano em São Paulo depende do ensino formal em cursos livres, às vezes com contribuições financeiras italianas, em escolas e universidades públicas brasileiras. Para a atualização linguistica deve-se considerar o suvsídio de RAI International.

Fourth International Congress on Industrial and Applied Mathematics. Book of Abstracts

Science.gov (United States)

1999-01-01

Dipartimento di Matematica , Universita’ di Pavia, Italy) Logarithmic Sobolev inequalities for kinetic semiconductor equations In this paper we analyze the...terms of Whitney forms. FERNANDES, Paolo (Istituto per la Matematica Applicata del Consiglio Nazionale delle Ricerche, Italy) Dealing with realistic... Matematica dell Universita di Pavia, Italy. PERUGIA, Ilaria (Diaprtimento di Matematica , Universita’ di Pavia - Italy) An adaptive field-based method

A Criterion to Identify Maximally Entangled Four-Qubit State

International Nuclear Information System (INIS)

Zha Xinwei; Song Haiyang; Feng Feng

2011-01-01

Paolo Facchi, et al. [Phys. Rev. A 77 (2008) 060304(R)] presented a maximally multipartite entangled state (MMES). Here, we give a criterion for the identification of maximally entangled four-qubit states. Using this criterion, we not only identify some existing maximally entangled four-qubit states in the literature, but also find several new maximally entangled four-qubit states as well. (general)

Los Requena, una enigmática familia de pintores del Renacimiento. A propósito de Gaspar Requena el Joven

Directory of Open Access Journals (Sweden)

Ferrer Orts, Albert

2009-06-01

Full Text Available Recent exhibitions produced by the Foundation La Luz de las Imágenes in Valencian dioceses has allowed for numerous works of art to be seen, admired and studied under optimal conditions. In this context we offer an approach to the workshop of the Requena family, painters active in the Kingdom of Valencia between approximately 1531 and 1605. These artists, in their uneven production, owed much to Paolo da San Leocadio, the Hernandos and particularly, Joan de Joanes.

Las recientes exposiciones que viene realizando la Fundación “La Luz de las Imágenes” en el ámbito de las distintas diócesis valencianas no sólo ha acercado al público numerosas obras de arte en condiciones de ser vistas y admiradas, sino que también ha posibilitado su estudio. En ese contexto presentamos un acercamiento al taller de los Requena; una familia de pintores activa en el Reino de Valencia entre 1531 y 1605 aproximadamente que, en su desigual producción, deja entrever las innegables deudas con Paolo da San Leocadio, los Hernandos y, particularmente, Joan de Joanes.

Deflating Autonomy: Human Interactivity in the Emerging Social World

DEFF Research Database (Denmark)

Cowley, Stephen; Gahrn-Andersen, Rasmus

2015-01-01

This article critiques recent enactivist attempts to bridge an epistemological divide between the individual and the social (i.e. to fill in the posited macro-micro gap). Its central claim is that an inflated view of ‘autonomy’ leads to error. Scrutinising two contributions, we find that methodol......This article critiques recent enactivist attempts to bridge an epistemological divide between the individual and the social (i.e. to fill in the posited macro-micro gap). Its central claim is that an inflated view of ‘autonomy’ leads to error. Scrutinising two contributions, we find...... that methodological solipsism taints Varela’s model: It induces De Jaegher & Di Paolo to ascribe social knowledge to perturbances – contingencies whose logic arises from the closed organization of an individual (De Jaegher & Di Paolo, 2007) and Steiner & Stewart to posit that the pre......-dispositions of an organizationally closed world prompt individuals to “receive” shared norms (Steiner & Stewart, 2009). On our deflated view, neither organizational closure nor participatory sense making apply to most human cognition. Rather, we invoke a developmental process based on the recursive self-maintenance that is found...

KM-Appunti : 5. KM e "nuova" logica

OpenAIRE

Bogliolo, Domenico

2002-01-01

Paolo Bisogno leaved many tracks that must be catalogued. One of his research paths, Knowledge Management, is a sort of “Science of knowledge organization” if we decide to join the idea of knowledge with practical, managerial and directional components. We will try to outline here an operative and epistemologic layout of knowledge modelling and categorizing, helping us in understanding new knowledge boundaries of KM.

For information: Geneva University

CERN Multimedia

2005-01-01

Ecole de physique Département de physique nucléaire et corspusculaire 24, Quai Ernest-Ansermet 1211 GENEVE 4 TéL: (022) 379 62 73 Fax: (022) 379 69 92 Lundi 5 décembre COLLOQUE DE PHYSIQUE at 17:00 - Stückelberg Auditorium ARCHEOLOGY OF THE UNIVERSE WITH THE COSMIC MICROWAVE BACKGROUND by Prof. Paolo de Bernardis / Université de Rome 'La Sapienza'

Interrogatorio del prof. Sylos Labini

Directory of Open Access Journals (Sweden)

Paolo Sylos Labini

2015-06-01

Full Text Available The article is a slightly edited reproduction of Paolo Sylos Labini’s 1962 testimony at the “Commission on the limits to competition” of the Italian Parliament. Sylos Labini recalls here his oligopoly theory, but he also extends his remarks to a full range of necessary structural reforms for Italy at the time. JEL codes: L13, D43, G30

Linking orogen and peripheral foreland basin: conceptual model and application to the Southalpine-Dinaric (Friuli) orocline

Science.gov (United States)

Heberer, Bianca; Neubauer, Franz

2010-05-01

Surface uplift and rock exhumation within an orogen are generally a consequence of convergence, and can often be linked with subsidence in a peripheral foreland. Since vertical loads act on the entire lithosphere, these processes can, therefore, be considered as plate-scale processes. Here, we propose a conceptual model for this linkage for the Friuli orocline and its surrounding units. The Friuli orocline stretches from the ENE-trending Southern Alps to the SE-trending Dinarides. There, two Neogene stages of convergence and associated deformation can be differentiated: (1) a Mid-Late Miocene phase of increased surface uplift and intra-orogenic subsidence of sedimentary basins reflecting intra-orogenic crustal-scale folding. Depocentres are e.g. the flexural Belluno, Ljubljana and Klagenfurt basins. (2) A second stage of convergence during Late Pliocene-Pleistocene times led to overall surface uplift in the orogen and contemporaneous pronounced subsidence in the peripheral foreland basin (Venetian platform and the northern Adriatic Sea). We propose, that the spatially variable extent of subsidence originates in variably strong orogen-basin coupling, i.e. weak coupling during stage 1 vs. strong coupling during stage 2. This interpretation is based on the apatite fission track age pattern, the distribution of intra-orogenic Neogene sediment basins and subsidence analyses in the foreland basin (Barbieri et al., 2007). Available low-temperature thermochronological data for the Southern Alps and the NW Dinarides are sparse, in contrast to a dense network of primarily apatite fission track ages north of the Periadriatic lineament (e.g. summarized by Luth & Willingshofer, 2008). AFT ages adjacent to the eastern Periadriatic Lineament mainly range from 15 to 25 Ma (Hejl, 1997; Fodor et al., 2008). Detrital studies on Oligocene to Miocene sediments from the Venetian foreland basin yielded dominant age groups clustering roughly around 20 and 30 Ma (Stefani et al., 2008

Convite à Leitura: Considerações Sobre a Narrativa de Paolo Nori

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Doris Nátia Cavallari

2010-12-01

Full Text Available Este texto é um convite à leitura de um autor pouco conhecido no Brasil e trata principalmente de suas primeiras produções, que tem como protagonista Learco Ferrari, um escritor em crise com a sua produção literária.

Reconstructing multiple identities: portuguese and afro-portuguese immigrantes in São Paolo

Directory of Open Access Journals (Sweden)

Demartini, Zeila de Brito Fabri

2006-11-01

Full Text Available In the 1970s and 1980s, migratory flows of Portuguese and luso-Africans from old Portuguese African colonies towards to São Paulo were the result of the pressures of difficult and complex African and Portuguese politics. Three very different cultural experiences were in play: that of the portuguese colony, the african context, and the Brazilian character of the destination, Sao Paulo. This paper explores the migrant's complex displacement experiences, the insertion of the migrant into the new context and the conflicts of identity that this migratory process entailed. We concentrate on the recent past, which has not been extensively researched. We use a method we call "summarized life-histories", which seemed appropriate, as we didn’t know what the immigrants would tell us. We present a number of specific cases to exemplify our analysis. Through them, we can see that memories refer to events, people and places from the three continents, through the conscious and unconscious construction of multiple identities.

Can Biosemiotics be a “Science” if its Purpose is to be a Bridge between the Natural, Social and Human Sciences?

DEFF Research Database (Denmark)

Brier, Søren

2015-01-01

to be that the optimal type of knowledge science can produce about living system is to model them as machines. But the explicit goal of a Peircean semiotically based biosemiotics is (also) to model living systems as cognitive and communicative systems working on the basis of meaning and signification. These two concepts...... are not part of the mechanistic models of natural science today, not even of cognitive science. Barbieri tries to solve this problem by introducing a new concept of biological meaning that is separate from the Peircean biosemiotics and then add Peirce's semiotics on top. This article argues why this view...... is inconsistent on the grounds that Peirce's semiotic paradigm only gives meaning in its pragmaticist conception of a fallibilist view of science, which again is intrinsic connected to its non-mechanistic metaphysics of Tychism, Synechism and Agapism. The core of the biosemiotic enterprise is to establish another...

Research Area 3: Mathematics (3.1 Modeling of Complex Systems)

Science.gov (United States)

2017-10-31

Title: RESEARCH AREA 3: MATHEMATICS (3.1 Modeling of Complex Systems). Proposal should be directed to Dr. John Lavery Report Term: 0-Other Email ...Paolo Rosso Email : prosso@dsic.upv.es values of the profile characteristics taken by the users), intersection (they represent the relationship between...accuracy, especially when adding fully connected layers at the end of the network. This work has resulted in the writing of a manuscript for the Journal

Accounting for intimate partner violence perpetration. A cross-cultural comparison of English and Brazilian male substance users' explanations

OpenAIRE

Radcliffe, Polly; Flávia Pires Lucas d'Oliveira, Ana; Lea, Susan; dos Santos Figueiredo, Wagner; Gilchrist, Gail

2016-01-01

Abstract Introduction and Aims This paper describes how substance use features in the accounts of intimate partner violence (IPV) perpetrators in treatment in England and Brazil. The aim of the research was to better understand cross cultural constructions of IPV perpetration amongst men in treatment for substance use. Design and Methods Semi?structured interviews were conducted with 40 men in community substance use treatment in Sao Paolo, Brazil and London and the South East of England who ...

Book Reviews

OpenAIRE

Redactie KITLV

2004-01-01

-Bill Maurer, Mimi Sheller, Consuming the Caribbean: From Arawaks to Zombies. New York: Routledge, 2003. ix + 252 pp. -Norman E. Whitten, Jr., Richard Price ,The root of roots: Or, how Afro-American anthropology got its start. Chicago: Prickly Paradigm Press/University of Chicago Press, 2003. 91 pp., Sally Price (eds) -Holly Snyder, Paolo Bernardini ,The Jews and the expansion of Europe to the West, 1450-1800. New York: Berghahn Books, 2001. xv + 567 pp., Norman Fiering (eds) -Bridget Brereto...

STUDIO AZZURRO: TRES DÉCADAS DE EXPERIMENTACIÓN EN LA CREACIÓN AUDIOVISUAL Y LOS ESPACIOS SENSORIALES.

OpenAIRE

VALDALISO CASANOVA, TERESA

2016-01-01

[EN] Studio Azzurro is, probably, the main exponent in the field of research, experimentation and artistic hybridization with regard to the audio-visual language and the new technologies, inside the current Italian scene. Founded in Milan in 1982 by three artists, Paolo Rosa, Fabio Cirifino and Leonardo Sangiorgi, from the beginning they have opted for the collaborative team work, distancing themselves from the opinions of the critique and from the art market. Characterized by a militant past...

Le minoranze islamiche nella Bulgaria post-comunista: ingerenze statali e libertà confessionale

Directory of Open Access Journals (Sweden)

Paola Fantelli

2011-03-01

Full Text Available Contributo segnalato dal Prof. Paolo Moneta, ordinario di Diritto ecclesiastico nella facoltà di Giurisprudenza dell’’Università di Pisa SOMMARIO: 1. Profili istituzionali delle relazioni tra Stato e confessioni religiose nella Bulgaria post-comunista: la posizione dell’Islam. 2. Le ingerenze del Governo bulgaro nell’organizzazione interna delle rappresentanze islamiche secondo la Corte di Strasburgo. 3. Alcune osservazioni sull’ingresso della Bulgaria nell’U.E. e sulle problematiche dell’Islam bulgaro – balcanico.

MEchatronic REspiratory System SImulator for Neonatal Applications (MERESSINA project: a novel bioengineering goal

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Scaramuzzo RT

2013-08-01

Full Text Available Rosa T Scaramuzzo,1,2 Massimiliano Ciantelli,1 Ilaria Baldoli,3 Lisa Bellanti,3 Marzia Gentile,1 Francesca Cecchi,3 Emilio Sigali,1 Selene Tognarelli,3 Paolo Ghirri,1–4 Stefano Mazzoleni,3 Arianna Menciassi,3 Armando Cuttano,1 Antonio Boldrini,1–4 Cecilia Laschi,3 Paolo Dario3 1Centro di Formazione e Simulazione Neonatale "NINA," UO Neonatologia, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy; 2Istituto di Scienze della Vita, 3The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy; 4Università di Pisa, Pisa, Italy Abstract: Respiratory function is mandatory for extrauterine life, but is sometimes impaired in newborns due to prematurity, congenital malformations, or acquired pathologies. Mechanical ventilation is standard care, but long-term complications, such as bronchopulmonary dysplasia, are still largely reported. Therefore, continuous medical education is mandatory to correctly manage devices for assistance. Commercially available breathing function simulators are rarely suitable for the anatomical and physiological realities. The aim of this study is to develop a high-fidelity mechatronic simulator of neonatal airways and lungs for staff training and mechanical ventilator testing. The project is divided into three different phases: (1 a review study on respiratory physiology and pathophysiology and on already available single and multi-compartment models; (2 the prototyping phase; and (3 the on-field system validation. Keywords: simulation, lung, newborn, continuous medical education, respiratory system

Geo morphological analysis of risk in the Joao Paolo formation (Manaus - AM, Brazil)

International Nuclear Information System (INIS)

Cassiano, K; Amazonas, A; Costa, R.

2010-01-01

This study aims to examine the geo system , the physiology and the geomorphology of the risk areas in public housing of Joao Paulo formation. This formation was built on a small plateau on a series of valleys, where are occupied by houses and passageways of different levels of infrastructure. There is a predominance of a yellow soil with a high level of weathering as well as a little vegetation. These characteristics associated with high rainfall and lack of infrastructure contribute to generate different type of soils

Our Energy For The Country Project Started Our Via Bona

International Nuclear Information System (INIS)

Anon

2014-01-01

Slovenske Elektrarne received the main Via Bona award for its complex and extraordinary approach to responsible business. Non-profit fund Pontis has been granting this award since 1998 to companies voluntarily contributing to the mitigation of negative trends and the improvement of positive business aspects beyond legislative requirements. We won with our Energy for the Country programme. The award was given to Paolo Ruzzini, SE CEO and Chairman of the Board of Directors by Andrej Kiska, the new Slovak President.

Tendenze interpuntorie in giovani narratori

OpenAIRE

Spinelli, Silvia

2016-01-01

Il saggio si concentra sull’analisi dei fenomeni interpuntori all’interno di alcuni romanzi scritti da giovani autori italiani e pubblicati dopo l’anno duemila: 100 colpi di spazzola prima di andare a dormire, di Melissa P. (2003), La ragazza dei miei sogni di Roberto Dimitri (2007), La solitudine dei numeri primi di Paolo Giordano (2008), La Panzanella di Giulia Villoresi (2009), Acciaio di Silvia Avallone (2010) e Troppa umana speranza di Alessandro Mari (2011). L’analisi comparata dei roma...

Chronostatigraphy of limistone sequency of north Brazilian coast based on data from stronium isotope

International Nuclear Information System (INIS)

Takaki, T.; Rodrigues, R.

1987-01-01

The strontium isotope composition of marine limestones can be a valuable tool for stratigraphic correlation, in addition to other techniques usually employed for this purpose. The technique can render particularly important in sequences where the fossil assemblage do not present good stratigraphic resolution. As examples, data from Mesozoic and Cenozoic limestone sequences of north Brazilian coast are here presented. Data on strontium isotope composition are compared to those obtained by De Paolo and Ingram in another geographic locations. (author) [pt

El fútbol y el héroe posmoderno

OpenAIRE

Pahuacho, Alonso

2016-01-01

The aim of this article is to reveal, through a critical analysis of the discourse,how the leading football player Paolo Guerrero has been built up in differentsporting newspaper articles as a new national hero who is able to incarnate acertain archetypical value (bravery), and introduce him as a lucky essence fromthe Peruvian national character. Through a thoughtful examination of the several discursive strategies often used by the sports press, this virtue is deconstructed in order to find ...

Reservsõjaväelasele Leo Kunnasele anti Stalkeri romaaniauhind / Kalev Kask, Kaarel Kressa

Index Scriptorium Estoniae

Kask, Kalev

2009-01-01

Eesti Ulmeühingu Stalkeri-nimelised auhinnad jaotusid järgmiselt: algupärase romaani auhind - Leo Kunnas (romaani "Gort Ashryn" 1. osa "Enne viimast sõda"), algupärase jutu auhind - Indrek Hargla ("Minu päevad Liinaga", ilm. Looming, 2008, nr. 8), algupärase lühijutu auhind - Laur Kraft ("Ultima Cthule", ilm. võrguajakirjas Algernon), tõlkeromaani auhind - Sergei Lukjanenko ("Öine Vahtkond"), kogumiku auhind - Poul Anderson ("Taevarahvas"), tõlkejutu auhind - Paolo Bacigalup ("Flööditüdruk")

Concept City: Roma ri-vista e vissuta ne La dolce vita e La grande bellezza

OpenAIRE

Martini, Alessia

2015-01-01

A partire dagli anni del neorealismo, Roma è stata una location particolarmente amata dai registi italiani che hanno utilizzato con finalità simboliche diversi luoghi della città—dalle borgate ai monumenti del centro—al fine di raccontare un preciso momento storico e una precisa situazione sociale. In questo articolo prenderò in considerazione due film ambientati a Roma, La dolce vita di Federico Fellini (1960) e La grande bellezza di Paolo Sorrentino (2013), per analizzare le valenze che la ...

Urban policies and citizenship. Some mechanisms for the production of urban space in the city of Sao Paulo

Directory of Open Access Journals (Sweden)

Roberto Rocco

1997-01-01

Full Text Available The article deals with the historical reasons for the present conditions in the city of Sao Paolo, attempts at managing the place, preparation of the master plan, problems with establishment of particular mechanisms for creating urban space and reasons for success or failure of particular endeavours. An important aspect in solving physical problems of future development is prevention of social and physical segregation. Urban policies are presented with three types of measures. In conclusion, two examples of policy implementation are shown.

Italy: A Post-Biopolitical Laboratory. From Pasolini’s "Il romanzo delle stragi” to De Cataldo’s Romanzo criminale

OpenAIRE

Fabbri, Lorenzo

2011-01-01

On March 29, 1969, from the pages of Tempo, Pier Paolo Pasolini asks: “Do Novelistic Lives Still Exist?”. In this article, Pasolini wonders whether the novel is still a contemporary literary form or if it is rather something which belongs to the past. He concludes that, as long as the real retains its novelistic structure, the novel will not become outdated. But why did Pasolini pose the question of the novelistic in such a time in Italian history? Pasolini was compelled by the unde...

Dark fragments: contrasting corporealities in Pasolini's La ricotta

OpenAIRE

Murphy, Jill

2014-01-01

The short film La ricotta (Pier Paolo Pasolini, 1963) tells the story of Stracci, an extra working on a film of the life of Christ, which is presented in part via tableaux vivants of Mannerist paintings. Pasolini’s film is replete with formal, stylistic and narrative binaries. In this article, I examine a particularly emphatic binary in the film in the form of the abstract, ethereal corporeality of the Mannerist paintings versus the raw and bawdy corporeality of Stracci. I show that through t...

La politicidad de la producción como fundamento técnico del marxismo obrerista (y post-obrerista)

OpenAIRE

Fagioli, Andrea

2013-01-01

En sus trabajos de este comienzo del siglo XXI, los filósofos italianos Paolo Virno y Antonio Negri - autores que llamamos post-obreristas por la continuidad con el núcleo del pensamiento del obrerismo - proponen una genealogía de las formas de producir contemporáneas. Una genealogía que considera la conflictividad obrera como el motor del desarrollo capitalista. Esta conflictividad viene a ser el impulso a los cambios productivos, como los que socavaron poderosamente la forma de producir a l...

A Social Media-Based Acute Alcohol Consumption Behavior (NekNomination): Case Series in Italian Emergency Departments.

Science.gov (United States)

Barbieri, Stefania; Feltracco, Paolo; Lucchetta, Vittorio; Gaudio, Rosa Maria; Tredese, Alberto; Bergamini, Mauro; Vettore, Gianna; Pietrantonio, Vincenzo; Avato, Francesco Maria; Donato, Daniele; Boemo, Deris Gianni; Nesoti, Maria Vittoria; Snenghi, Rossella

2018-01-31

1.6% (7/450) of cases; binge drinking and other alcoholic games caused 23.3% (105/450) and 23.8% (107/450) of hospitalizations, respectively. On admission, 44.2% (199/450) of patients were assigned a red or yellow color code requiring immediate medical attention; about 14% of them required additional medical assistance (after being in the ED) or hospitalization, some in semi-intensive care units. Our study shows that the increased numbers of hospitalizations due to alcohol intoxication in the adolescent age group, as a consequence of NekNominate or other drinking games, is alarming and represents a serious public health issue. The potential markers of improper use of social networks must be clearly identified, including categories at risk of alcohol abuse, in order to develop intervention and prevention strategies in terms of education and awareness, which may help in averting potentially fatal episodes. ©Stefania Barbieri, Paolo Feltracco, Vittorio Lucchetta, Rosa Maria Gaudio, Alberto Tredese, Mauro Bergamini, Gianna Vettore, Vincenzo Pietrantonio, Francesco Maria Avato, Daniele Donato, Deris Gianni Boemo, Maria Vittoria Nesoti, Rossella Snenghi. Originally published in the Interactive Journal of Medical Research (http://www.i-jmr.org/), 31.01.2018.

Proceedings of the 20th ASPA Congress, Bologna, June 11-13, 2013

Directory of Open Access Journals (Sweden)

Guest Editors: A. Piva, P. Bosi, A. Bonaldo, F. Sirri, A. Badiani, G. Biagi, R. Davoli, G. Martelli, A. Meluzzi, P. Trevisi

2013-06-01

Full Text Available The 20th Congress of the Animal Science and Production Association (ASPA, is held in the prestigious home of the oldest university of the world: Bologna. The anniversary also celebrates the 40th year of the founding of the Society and is an occasion to remember the past and plan for the future of Animal Sciences in Italy. In this Congress, 137 oral presentations and 155 posters are presented, for a total of 292 scientific contributions. The Congress sessions with their relative number of papers are listed as follows: Animal breeding and genetics 109, Nutrition and feeding 45, Dairy production 42, Animal welfare, health and behaviour 39, Meat quality 35, Poultry and rabbit production 11 and Aquaculture 11. I would like to point out that 3 main lectures will be presented in the Animal breeding and genetics, Nutrition and feeding and Animal welfare, health and behaviour sessions, respectively. I would thank, first of all, Prof. Vincenzo Russo, Honorary President of the Congress and Emeritus of ASPA, for the contribution of the University of Bologna in organizing this event. I would also thank all the members of the Scientific Committee, Prof. Andrea Piva (Chairperson, Prof. Anna Badiani, Prof. Giacomo Biagi, Dr. Alessio Bonaldo, Prof. Paolo Bosi, Prof. Roberta Davoli, Prof. Luca Fontanesi, Prof. Giovanna Martelli, Prof. Adele Meluzzi, Dr. Attilio Mordenti, Prof. Luca Sardi, Dr. Federico Sirri, Dr. Paolo Trevisi, and of the Organizing Committee, Prof. Claudio Cavani (Chairperson, Prof. Stefania Dall’Olio, Prof. Andrea Formigoni, Prof. Pier Giorgio Monetti, Prof. Leonardo Nanni Costa, Dr. Massimiliano Petracci, Prof. Giuliano Zaghini, Dr. Paolo Zambonelli. A special thanks to the secretary of the Congress, MV Congressi. Indeed, I would like to congratulate and thank all those who have organized the meeting and have collaborated in reviewing the summaries for what they have done for ASPA and the Italian Animal Science. A special thanks to Prof

Moneta e Credito: storia e prospettive di una rivista (Money And Credit: History And Prospects Of A Magazine

Directory of Open Access Journals (Sweden)

Alessandro Roncaglia

2009-12-01

Full Text Available Con questo numero speciale si apre una nuova stagione della storia della nostra rivista. In una fase di ristrutturazioni interne, la Banca Nazionale del Lavoro ha concordato la cessione della proprietà della rivista stessa e della sua consorella Quarterly Review all' Associazione Paolo Sylos Labini, mantenendo un collegamento tramite una sponsorizzazione. In questo modo è stato possibile salvare due riviste con una storia lunga e prestigiosa, conservandone intatto l'orientamento verso la ricerca e il dibattito scientifico nel campo della teoria e della politica economica, con attenzione particolare ma non esclusiva per gli aspetti monetari e finanziari e senza alcuna preconcetta scelta di campo tra le diverse scuole di pensiero. With this special issue opens a new era in the history of our magazine. In a period of internal restructuring, the Banca Nazionale del Lavoro agreed on the transfer of ownership of the magazine itself and all of its sister Quarterly Review 'Association Paolo Sylos Labini, while maintaining a connection via a sponsorship. In this way it was possible to save two magazines with a long and prestigious history, keeping intact the orientation towards research and scientific debate in the field of economic theory and policy, with particular but not exclusive attention to the monetary and financial aspects and without any preconceived choice of field between the different schools of thought.  JEL Codes: E44, G01 

Una lettera a Sylos Labini. (A letter to Sylos Labini

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Franco Modigliani

2014-10-01

Full Text Available The letter, dated 14 September 1956, starts a decade long correspondence between Franco Modigliani and Paolo Sylos Labini. Here Modigliani discusses at length a first draft of Sylos Labini’s book on oligopoly theory. Differently from Modigliani’s well known 1958 review of the book, Modigliani focuses here not mainly on the structure of oligopoly industries, but especially on the macroeconomic implications of Sylos Labini’s model. The letter is reproduced with Sylos Labini’s annotated comments on Modigliani’s remarks. JEL codes: B31, D43, E13

Prefazione al quinto volume di GERBERTVS

Science.gov (United States)

Sigismondi, Costantino

The act of the symposia dedicated to Gerbert of Aurillac in Rome on May 10, 2013 and May 12, 2014 are here published with contributions from Wojciech Janusiewicz on Gerbert and Poland, Flavio G. Nuvolone on Gerbert and Boethius, Gerbert and the violence, Marek Otisk on the use of Boethius Arithmetica in X century, Paolo Colona on the Poet Petrarca (XIV century) and Astronomy. Costantino Sigismondi contributes with several works dealing with history of astronomy and observational astronomy, especially the one of variable stars with naked eye, for the great didactical value of such observations.

History of the early dipteran systematics in Italy: from Lyncei to Battista Grassi.

Science.gov (United States)

Baccetti, B

2008-12-01

This presentation starts with Galileo's discovery of the microscope and the first Lyncei. Giovanni Heckius and Francesco Stelluti demonstrated different kinds of mosquitoes. Later, in Florence, the Academy of Cimento solved the problem of mosquito reproduction with the discoveries of Francesco Redi, Pietro Paolo da Sangallo, Giuseppe Del Papa and Giovanni Maria Lancisi in the 18th century. In 19th century Eugenio Ficalbi reviewed the Italian Culicids. Once Battista Grassi solved the cycle of Anopheles and Plasmodia, further researches followed by Golgi, Celli, Marchiafava, Bastianelli and Bignami, as well as by Roland Ross.

Confocal scanning microscopy

DEFF Research Database (Denmark)

Bariani, Paolo

This report is based on a metrological investigation on confocal microscopy technique carried out by Uffe Rolf Arlø Theilade and Paolo Bariani. The purpose of the experimental activity was twofold a metrological instrument characterization and application to assessment of rough PP injection moulded...... replicated topography. Confocal microscopy is seen to be a promising technique in metrology of microstructures. Some limitations with respect to surface metrology were found during the experiments. The experiments were carried out using a Zeiss LSM 5 Pascal microscope owned by the Danish Polymer Centre...

Selected Abstracts of the 2nd International Workshop “Intensive Care of the Newborn”; Verona (Italy); March 9-10, 2018

OpenAIRE

--- Various Authors

2018-01-01

Selected Abstracts of the 2nd International Workshop “Intensive Care of the Newborn”; Verona (Italy); March 9-10, 2018CONGRESS PRESIDENTPaolo Biban  Guest Editor: Paolo BibanABS 1. DOES DELAYED CORD CLAMPING (DCC) AFFECT UMBILICAL CORD pH IN PRETERM INFANTS? • V.M. Samedi, L. Irvine, S. Thomas, D. Kowal, J. Rabi, A. Stritzke, N. Singhal, A. Abou MehremABS 2. SNAP-PE SCORE. MORBIDITY AND MOR­TALI­TY INDEX IN NICUs • A. Konstantinidi, R. Sokou, S. Parastatidou, A. Tsantes, N. IacovidouABS 3. EA...

Influence of cooking process on protein fractions in cooked ham and mortadella

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G. Vonghia

2011-03-01

Full Text Available The mortadella is a pork meat sausage (in natural or artificial bowel accurately triturated and mixed with little backfat cubes, salt, sodium nitrate and nitrite, spices and peppercorns, and then cooked in oven for many hours. The cooked ham is obtained from an anatomically completed piece of meat; the working process provides the addiction of salt and spices, the brine, the bones removal, the churning and the pressing, so the cured meat is first packed in a mould provided for this purpose, then cooked and after cooled and packed. The meat cooking is the last step in the cooked sausage production technology, and let us obtain a stable and eatable product. The effect of the heat and the lenght of processing are the main responsibles for modifications in water- and salt-soluble protein fractions. Indeed myofibrils denature themselves after cooking and consequently their solubility decreases; particularly the denaturation begins over 30°C in the myosin chain, instead the actin solubility begins to decrease over 60°C, being the actin more stable than myosin (Barbieri et al., 1997...

Testing SUSY

CERN Document Server

Cassel, S; Ross, G G

2010-01-01

If SUSY provides a solution to the hierarchy problem then supersymmetric states should not be too heavy. This requirement is quantified by the Barbieri-Giudice fine tuning measure that provides a quantitative test of SUSY as a solution to the hierarchy problem. The measure is useful in correlating the impact of the various experimental measurements relevant to the search for supersymmetry and also in identifying the most sensitive measurements for testing SUSY. In this paper we apply the measure to the CMSSM, computing it to two-loop order and taking account of current experimental limits and the constraint on dark matter abundance. Using this we determine the present limits on the CMSSM parameter space and identify the measurements at the LHC that are most significant in covering the remaining parameter space. Without imposing the LEP Higgs mass bound we show that the smallest fine tuning (1:14.5) consistent with a saturation of the relic density within the 1$\\sigma$ WMAP bounds corresponds to a Higgs mass o...

Academic Training: 2004 - 2005 ACADEMIC TRAINING PROGRAMME

CERN Multimedia

Françoise Benz

2004-01-01

1st Term - 01 October to 17 December 2004 REGULAR LECTURE PROGRAMME New Trends in Fusion Research by A. Fasoli, EPFL, Lausanne, CH 11, 12, 13 October Physics at e+e- linear collider by K. Desch, DESY, Hamburg, D 15, 16, 17, 18, 19 November LECTURE SERIES FOR POSTGRADUATE STUDENTS Standard Model by R. Barbieri, CERN-PH-TH 6, 7, 8, 9 10 December The lectures are open to all those interested, without application. The abstract of the lectures, as well as any change to the above information (title, dates, time, place etc) will be published in the CERN Bulletin, the WWW, and by notices before each term and for each series of lectures. ENSEIGNEMENT ACADEMIQUE ACADEMIC TRAINING Françoise Benz 73127 academic.training@cern.ch If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form a...

2004-2005 Academic Training Programme: Electroweak Theory and the Standard Model

CERN Multimedia

Françoise Benz

2004-01-01

6, 7, 8, 9 and 10 December LECTURE SERIES 6, 7, 8, 9, 10 December from 11:00 to 12:00 - Main Auditorium, bldg. 500 on 6, 7, 8, 10 December, TH Auditorium, bldg. 4 3-006 on 9 December Electroweak Theory and the Standard Model R. BARBIERI / CERN-PH-TH There is a natural splitting in four sectors of the theory of the ElectroWeak (EW) Interactions, at pretty different levels of development /test. Accordingly, the 5 lectures are organized as follows, with an eye to the future: Lecture 1: The basic structure of the theory; Lecture 2: The gauge sector; Lecture 3: The flavor sector; Lecture 4: The neutrino sector; Lecture 5: The EW symmetry breaking sector. Transparencies available at: http://agenda.cern.ch/fullAgenda.php?ida=a042577 ENSEIGNEMENT ACADEMIQUE ACADEMIC TRAINING Françoise Benz 73127 academic.training@cern.ch If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can ...

2004-2005 Academic Training Programme: Electroweak Theory and the Standard Model

CERN Multimedia

Françoise Benz

2004-01-01

6, 7, 8, 9 and 10 December LECTURE SERIES 6, 7, 8, 9, 10 December from 11:00 to 12:00 - Main Auditorium, bldg. 500 on 6, 7, 8, 10 December, TH Auditorium, bldg. 4 3-006 on 9 December Electroweak Theory and the Standard Model R. BARBIERI / CERN-PH-TH There is a natural splitting in four sectors of the theory of the ElectroWeak (EW) Interactions, at pretty different levels of development /test. Accordingly, the 5 lectures are organized as follows, with an eye to the future: Lecture 1: The basic structure of the theory; Lecture 2: The gauge sector; Lecture 3: The flavor sector; Lecture 4: The neutrino sector; Lecture 5: The EW symmetry breaking sector. ENSEIGNEMENT ACADEMIQUE ACADEMIC TRAINING Françoise Benz 73127 academic.training@cern.ch Si vous désirez participer à l'un des cours suivants, veuillez en discuter avec votre superviseur et vous inscrire électroniquement en direct depuis les pages de description des cours dans le Web que vous trouvez &ag...

Ni escolásticos ni jansenistas: Filosofía moral en el Nápoles de la Contrarreforma

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Luna-Fabritius, Adriana

2016-06-01

Full Text Available This article reveals key elements of the Neapolitan intellectual map of the Counter-Reformation one of the most complex and fascinating of the Italian history at the dawn of the Enlightenment. The main objective is to resettle the place of both Jansenism and Scholastics to the Neapolitan intellectual history of the first half of the eighteenth Century. This article places the Letters addressed to the Father General of the Society of Jesus written by the patrician Genoese and political philosopher Paolo Mattia Doria in the context of the Inquisition’s trial against the atheists-atomists (1688-1697, whose echoes were heard all the way to the first decades of the eighteenth Century.Este artículo revela elementos clave del mapa intelectual napolitano de la era de la Contrarreforma, que fue uno de los más complejos y fascinantes de la historia Italiana en los albores de la Ilustración. El objetivo es restablecer el lugar tanto del jansenismo como de la Escolástica para la historia intelectual napolitana de la primera mitad del siglo XVIII. Para ello, este artículo sitúa las Cartas dirigidas al Padre General del Compañía de Jesús (1731 del patricio genovés y filósofo político Paolo Mattia Doria en el contexto del juicio de la Inquisición a los ateístas-atomistas de 1688-1697, cuyos ecos se escucharon aún durante las primeras décadas del siglo XVIII.

25 years of service at CERN

CERN Multimedia

2014-01-01

The 28 staff members having achieved 25 years of service at CERN in 2014 were invited by the Director-General to a reception in their honour on 25 November 2014.       Alberto AIMAR IT   Patrick BERLINGHI  GS   Horst  BREUKER  PH   Paolo  CHIGGIATO  TE   Jorgen  CHRISTIANSEN PH   Ivan  DELOOSE  IT   Martine   DESNYDER-IVESDAL  PH   Laurent  DUCIMETIERE   TE   Bruno  DUPUY  BE   Alan James  FINDLAY  BE   Jean-Jacques   GRAS BE   Michael  HAUSCHILD PH   Erk  JENSEN  BE   Michael  LAMONT&...

El cine poesía en Pasolini, Bolaño y Scherson

OpenAIRE

Patricia Espinosa H

2015-01-01

En el presente trabajo se plantea que Una novelita lumpen de Roberto Bolaño y su transposición cinematográfica El futuro de Alicia Scherson actualizan elementos de "Cine de poesía" de Pier Paolo Pasolini. Si bien Bolaño y Scherson desmontan la oposición pasoliniana entre "lenguaje de poesía" y "lenguaje de prosa" por medio de la hibridación de géneros, coinciden con el cineasta italiano en cuanto a rechazar la estandarización de las formas de narrar. Este fenómeno se caracteriza por el predom...

Theatrical Complicity as a Medium of Emancipation

DEFF Research Database (Denmark)

Nielsen, Thomas Rosendal

2015-01-01

How do we find a solution when we ourselves are the problem? This is the question posed by two contemporary performances that frame the spectator as an accomplice in the exploitation and representation of suffering and violence in a globalized and mediatized world: Sálo (2010), based on Pier Paolo...... are analysed and compared as elaborately structured games of observation, where the spectators are made to observe their own acts of spectating as complicity in the reproduction of violence caused by theatrical representation. Jaques Rancière’s paradox of the spectator and Josette Féral’s concept...

La Reggenza et les autorisations : l’application des lois sur les fidéicommis et la mainmorte dans la Toscane des Lorraines (1737-1765

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Lara Marchi

2010-05-01

Full Text Available Date de soutenance : le 19 décembre 2009 à l’ÉHESS 54 Boulevard. Raspail, Paris.Composition du juryMonsieur Gérard Delille, Directeur d’études à l’éHESS (Directeur de thèse, Monsieur Eric Brian, Directeur d’études à l’ÉHESS et Directeur scientifique adjoint de l’INSHS du CNRS, Monsieur Marcello Verga, Professeur à Université de Sciences Politiques« Cesare Alfieri » de Florence, Monsieur Paolo Malanima, Directeur de l’Istituto di Studi sulle Società del Mediterraneo du CNR de Naples et Profes...

Music and medicine

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Donatella Lippi

2010-08-01

Full Text Available Donatella Lippi1, Paolo Roberti di Sarsina2, John Patrick D’Elios11History of Medicine, Department of Anatomy, Histology, and Forensic Medicine, University of Florence, Florence, Italy; 2Health Local Unit, Department of Mental Health, Bologna, ItalyAbstract: Healing sounds have always been considered in the past an important aid in medical practice, and nowadays, medicine has confirmed the efficacy of music therapy in many diseases. The aim of this study is to assess the curative power of music, in the frame of the current clinical relationship.Keywords: history of medicine, medical humanities, healing music

L'espace du mouvement: Une analyse des conflits dans les interactions entre institutrice et eleves d'une ecole maternelle

Science.gov (United States)

Galvão, Izabel

1995-01-01

The research described in this article, winner of the Gottfried Hausmann Prize for 1994, was carried out in a kindergarten in São Paolo, Brazil, using the theory developed by Henri Wallon. The aim was to examine how primary school children are affected in their development by: (a) unnecessary restrictions placed on their physical movements during lessons; and (b) failure to organize the classroom space in a way that assists the learning process. The author concludes that these factors lead to tensions in the classroom which could be avoided through a different approach to movement and space.

2013 CIME Course Vector-valued Partial Differential Equations and Applications

CERN Document Server

Marcellini, Paolo

2017-01-01

Collating different aspects of Vector-valued Partial Differential Equations and Applications, this volume is based on the 2013 CIME Course with the same name which took place at Cetraro, Italy, under the scientific direction of John Ball and Paolo Marcellini. It contains the following contributions: The pullback equation (Bernard Dacorogna), The stability of the isoperimetric inequality (Nicola Fusco), Mathematical problems in thin elastic sheets: scaling limits, packing, crumpling and singularities (Stefan Müller), and Aspects of PDEs related to fluid flows (Vladimir Sverák). These lectures are addressed to graduate students and researchers in the field.

The biggest investment in the history of Slovakia

International Nuclear Information System (INIS)

Anon

2009-01-01

On 11 June 2009 the General Director and Chairman of the Board of Directors of Slovenske elektrarne Paolo Ruzzini and the Prime Minister of the Slovak Republic Robert Fico announced the signature of contracts with the main suppliers for the completion of units 3 and 4 of Mochovce Nuclear Power Plant. Planned investment of Eur 2.775 billion by 2013 for the Mochovce completion is an important commitment for us and especially in this time, such investment can mitigate the impact of global slowdown in economic growth which impacts Slovakia but also other economies of the world. (author)

Garoto-propaganda Casas Bahia: configuração e estratégia

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João, Aléxon Gabriel

2015-01-01

O fio condutor da análise dos anúncios é a construção discursiva, passando pelos princípios norteadores de Bakhtin que entende o texto como um suporte material que dialoga em diferentes níveis com o consumidor. Além do teórico russo, foram incorporados os conceitos de Eliseo Verón, Patrick Charaudeau e Paolo Fabbri. No caso do Garoto-propaganda Casas Bahia, a forma, o estilo e a maneira de anunciar os produtos da empresa parecem apontar para estratégias e movimentos muito peculiares que favor...

La ayahuasca te da tu arte

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Paolo del Aguila

2014-09-01

Full Text Available Para Paolo del Águila, descendiente del pueblo asháninka, la creatividad es un don de las plantas. Durante su primera experiencia visionaria, la ayahuasca personificada en el cuerpo de anciana le entregó unos pinceles y un estilo propio, liberándolo de las disputas y los convencionalismos que había encontrado en la escuela de arte en Pucallpa. Desde entonces, pintura y vida son indisociables y su objetivo como artista es comunicar al público las experiencias espirituales que le acontecieron en un ámbito normalmente invisible que él se esfuerza por visibilizar.

Páginas iniciais

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Ficha catalográfica e sumário bilíngue

2013-09-01

Full Text Available REDES, Santa Cruz do Sul, v. 18, nº 2, p. 1 - 273, maio/ago. 2013. ISSN: 1982-6745 Editores Virginia Elisabeta Etges Silvio Cezar Arend Sumário/Summary A EFETIVIDADE DA COLABORAÇÃO ENTRE ORGANIZAÇÕES DO ARRANJO PRODUTIVO LOCAL (APL: EXPERIÊNCIAS DOS PROCESSOS LOGÍSTICOS NAS INDÚSTRIAS DO VALE DA ELETRÔNICA DE MINAS GERAIS – BRASIL THE EFFECTIVENESS OF COLLABORATION INTER-COMPANIES: EXPERIENCES OF LOGISTIC PROCESSES IN THE INDUSTRIES OF THE ELECTRONIC VALLEY OF MINAS GERAIS – BRAZIL Ricardo Silveira Martins Osmar Vieira de Souza Filho IDENTIFICAÇÃO DE CLUSTERS INDUSTRIAIS: UMA APLICAÇÃO DE ÍNDICES DE ESPECIALIZAÇÃO E CONCENTRAÇÃO, E ALGUMAS CONSIDERAÇÕES IDENTIFICATION OF INDUSTRIAL CLUSTERS: AN APPLICATION OF INDICES OF SPECIALIZATION AND CONCENTRATION, AND SOME CONSIDERATIONS Autenir Carvalho de Rezende Bernardo Palhares Campolina Diniz CAPACIDADES LOCAIS: POR UMA NOVA ECONOMIA DOS TERRITÓRIOS PRODUTIVOS LOCAL CAPACITIES: FOCUSING ON A NEW ECONOMY FOR PRODUCTIVE TERRITORIES Giancarlo Corò Paolo Gurisatti ANÁLISE CRÍTICA DA INFLUÊNCIA DO CAPITALISMO TRANSNACIONAL SOBRE AS INSTITUIÇÕES E ORGANIZAÇÕES CRITICAL ANALYSIS OF THE INFLUENCE OF TRANSNATIONAL CAPITALISM ON INSTITUTIONS AND ORGANIZATIONS José G. Vargas-Hernández REDES SOCIAIS E GOVERNANÇA DEMOCRÁTICA: O CASO DE UMA INSTITUIÇÃO FEDERAL DE ENSINO SUPERIOR DE MINAS GERAIS – BRASIL NETWORKS AND DEMOCRATIC GOVERNANCE: THE CASE OF A PUBLIC INSTITUTION OF HIGHER EDUCATION OF MINAS GERAIS – BRAZIL Edimilson Eduardo da Silva Fábio Costa Lasmar José Roberto Pereira DE MATRIZ CONSERVADORA A UMA POSTURA PROGRESSISTA: CATOLICISMO SOCIAL NO RIO GRANDE DO SUL (RS - BRASIL FROM A CONSERVATIVE MATRIX TO A PROGRESSIVE ATTITUDE: SOCIAL CATHOLICISM IN RIO GRANDE DO SUL (RS - BRAZIL Olgário Paulo Vogt Roberto Radünz DO PREJUÍZO À TRANSGRESSÃO: O DISCURSO SOBRE O MOVIMENTO GREVISTA NA IMPRENSA INJURY TO THE TRANSGRESSION: THE DISCOURSE ON STRIKE IN THE PRESS

The impossible interview with the man of the hidden biological structures. Interview by Paolo Mazzarello.

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Golgi, Camillo

2006-12-01

This paper presents an "impossible interview" to Professor Camillo Golgi, placed in time in December 1906. The Italian Professor Golgi from Pavia has been awarded the Nobel Prize for Physiology or Medicine ex aequo with the Spanish anatomist Santiago Ramón y Cajal. Both scientists have obtained the award for their work on the anatomy of the nervous system. However, they have opposite views on the mechanisms underlying nervous functions. Golgi believes that the axons stained by his "black reaction" form a continuous anatomical or functional network along which nervous impulses propagate. Ramón y Cajal is the paladin of the neuron theory, a hypothesis questioned by Golgi in his Nobel lecture of Tuesday, December 11. After the ceremony, an independent journalist has interviewed Professor Golgi in the Grand Hotel in Stockholm. Excerpts about his education, his main scientific discoveries, and his personal life are here given (reconstructing the "impossible interview" on the basis of Golgi's original writings).

Teoria dell’occupazione: due impostazioni a confronto. (The theory of employment: two approaches compared

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Alessandro Roncaglia

2014-10-01

Full Text Available Introducing the publication of a long 1956 letter by Franco Modigliani (FM to Paolo Sylos Labini (PSL on the draft of PSL’s book, Oligopoly and Technical Progress, the paper critically reviews the theoretical background of FM’s comments, showing how the pre-Keynesian roots dominate the so-called neoclassical synthesis as well as its shaky foundations. The paper also discusses FM’s interpretation of PSL’s oligopoly theory, as well as their collaboration (and differences on policy issues, such as their opposition to the 100% money wage indexation adopted in Italy from the mid-1970s to the mid-1980s. 

5th Paris-Princeton Lectures on Mathematical Finance

CERN Document Server

Benth, Fred Espen; Guasoni, Paolo; Manolarakis, Konstantinos; Muhle-Karbe, Johannes; Nee, Colm; Protter, Philip

2013-01-01

The current volume presents four chapters touching on some of the most important and modern areas of research in Mathematical Finance: asset price bubbles (by Philip Protter); energy markets (by Fred Espen Benth); investment under transaction costs (by Paolo Guasoni and Johannes Muhle-Karbe); and numerical methods for solving stochastic equations (by Dan Crisan, K. Manolarakis and C. Nee).The Paris-Princeton Lecture Notes on Mathematical Finance, of which this is the fifth volume, publish cutting-edge research in self-contained, expository articles from renowned specialists. The aim is to produce a series of articles that can serve as an introductory reference source for research in the field.

Colliding worlds: A journey in time and space through the solar system (Farinella Prize Lecture)

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Marchi, S.

2017-09-01

The evolution of the interiors, surfaces, and atmospheres of solid bodies in the solar system is affected by interplanetary collisions. From Mercury to the outskirts of the solar system, collisions with leftover planetesimals -asteroids, comets and their debris- provide a primary evolutionary process. Impact craters mark this evolution and provide a diagnostic tool, which coupled with modeling and, when possible, sample analysis, allow us to unravel the ancient history of the solar system. In this prize talk, I will present a few selected cutting-edge research topics at the frontier between modeling and space exploration that without any doubt would have deeply interested the curious mind of Paolo Farinella.

Remembering John M. Olson (1929-2017).

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Blankenship, Robert E; Brune, Daniel C; Olson, Jon C

2018-02-19

Here we provide reflections of and a tribute to John M. Olson, a pioneering researcher in photosynthesis. We trace his career, which began at Wesleyan University and the University of Pennsylvania, and continued at Utrech in The Netherlands, Brookhaven National Laboratory, and Odense University in Denmark. He was the world expert on pigment organization in the green photosynthetic bacteria, and discovered and characterized the first chlorophyll-containing protein, which has come to be known as the Fenna-Matthews-Olson (FMO) protein. He also thought and wrote extensively on the origin and early evolution of photosynthesis. We include personal comments from Brian Matthews, Raymond Cox, Paolo Gerola, Beverly Pierson and Jon Olson.

Amministrare lo studio dell'italiano: l'Ufficio Scolastico del Consolato Generale d'Italia a San Paolo

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Alessandro Dell'Aira

2006-08-01

Full Text Available Questo articolo riprende in parte una questione generale già affrontata sulla rivista, e cioè il buon uso delle tecnologie dell'informazione e della comunicazione in ambito culturale e didattico. La questione riguarda soprattutto gli stili di insegnamento/apprendimento, di formazione e di amministrazione. Ci si sofferma sullo stile di gestione di un ufficio pubblico in una situazione amministrativa atipica, esercitata su un territorio vastissimo a favore di un'utenza dislocata sul territorio in modo non omogeneo. La conclusione è che l'uso agile e sistematico della rete globale e delle tecnologie informatiche e telematiche può aiutare gli Uffici scolastici italiani all'estero a gestire in contesti complessi i principali problemi connessi con la distanza dall'Italia, sia per l'insegnamento della lingua italiana nei corsi, sia per la formazione iniziale e continua dei docenti.

Selected Lectures of the 2nd International Workshop “Intensive Care of the Newborn”; Verona (Italy; March 9-10, 2018

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--- Various Authors

2018-03-01

Full Text Available Selected Lectures of the 2nd International Workshop “Intensive Care of the Newborn”; Verona (Italy; March 9-10, 2018 CONGRESS PRESIDENT Paolo Biban  Guest Editor: Paolo BibanLECT 1. RESUSCITATION OF EXTREMELY PREMATURE INFANTS: HOW TO IMPROVE EVEN FURTHER • J.M. PerlmanLECT 2. MAINTAINING NORMAL TEMPERATURE IN THE NEWLY BORN: NOT A TRIVIAL GAME • J. WyllieLECT 3. PRESENT AND FUTURE OF SURFACTANT AD­MINISTRATION IN PRETERM INFANTS WITH RESPIRATORY DISTRESS SYNDROME (RDS • A. KribsLECT 4. CONTINUOUS POSITIVE AIRWAY PRES­SURE (CPAP, SURFACTANT, OR BOTH? A DILEMMA STILL WAITING TO BE SOLVED • D. De LucaLECT 5. NON-INVASIVE RESPIRATORY SUPPORT AND RESPIRATORY DISTRESS SYNDROME (RDS: IS NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE (nCPAP ALWAYS ENOUGH? • G. Lista, I. BresestiLECT 6. NEURALLY ADJUSTED VENTILATORY ASSIST (NAVA IN THE NEWBORN: A NEW STANDARD OF CARE? • H. SteinLECT 7. HIGH-FREQUENCY, MULTI-FREQUENCY OSCIL­LA­TION, JET VENTILATION: WHERE ARE WE? • J.J. PillowLECT 8. SURVIVAL AND NEURODEVELOPMENTAL OUT­COME IN PERIVIABLE INFANTS • N. YoungeLECT 9. PATHOPHYSIOLOGY AND TREATMENT OF SEPTIC SHOCK IN NEONATES • H.R. WongLECT 10. CLINICAL METABOLOMICS IN NEONATAL SEPSIS • V. FanosLECT 11. OPTIMIZING EARLY NUTRITION SUPPORT IN VERY LOW BIRTH WEIGHT (VLBW INFANTS • T. SenterreLECT 12. LONG-TERM ADVERSE EFFECTS OF EARLY GROWTH ACCELERATION OR CATCH-UP GROWTH • A. SinghalLECT 13. ROLE OF NEAR INFRARED SPECTROSCOPY DURING NEONATAL TRANSITION • B. UrlesbergerLECT 14. HEART RATE CHARACTERISTICS AS PHYSIO­MARKERS FOR DETECTION OF SEPSIS AND OTHER DISEASES • K.D. FairchildLECT 15. ENHANCED CARDIORESPIRATORY MONI­TORING OF THE PRETERM INFANT DURING STABILIZA­TION IN THE DELIVERY ROOM • E. Dempsey

Current and emerging treatments for the management of osteogenesis imperfecta

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Elena Monti

2010-08-01

Full Text Available Elena Monti1, Monica Mottes1, Paolo Fraschini2, PierCarlo Brunelli3, Antonella Forlino4, Giacomo Venturi1, Francesco Doro1, Silvia Perlini1, Paolo Cavarzere1, Franco Antoniazzi11Department of Life Sciences and Reproduction, Pediatric Clinic University of Verona, Verona, Italy; 2Istituto Di Ricovero e Cura a Carattere Scientifico, ‘E. Medea’, Associazione La Nostra Famiglia, Bosisio Parini (LC, Italy; 3Divisione di Ortopedia Pediatrica, Spedali Civili, Brescia, Italy; 4Department of Biochemistry “A. Castellani”, University of Pavia, ItalyAbstract: Osteogenesis imperfecta (OI is the most common bone genetic disorder and it is characterized by bone brittleness and various degrees of growth disorder. Clinical severity varies widely; nowadays eight types are distinguished and two new forms have been recently described although not yet classified. The approach to such a variable and heterogeneous disease should be global and therefore multidisciplinary. For simplicity, the objectives of treatment can be reduced to three typical situations: the lethal perinatal form (type II, in which the problem is survival at birth; the severe and moderate forms (types III–IX, in which the objective is ‘autonomy’; and the mild form (type I, in which the aim is to reach ‘normal life’. Three types of treatment are available: non-surgical management (physical therapy, rehabilitation, bracing and splinting, surgical management (intramedullary rod positioning, spinal and basilar impression surgery and medical-pharmacological management (drugs to increase the strength of bone and decrease the number of fractures as bisphosphonates or growth hormone, depending on the type of OI. Suggestions and guidelines for a therapeutic approach are indicated and updated with the most recent findings in OI diagnosis and treatment.Keywords: osteogenesis imperfecta, bone genetic disorder, bone brittleness, “brittle bone disease”, connective tissue malfunction, short

Division B Commission 6: Astronomical Telegrams

Science.gov (United States)

Yamaoka, H.; Green, D. W. E.; Samus, N. N.; Aksnes, K.; Gilmore, A. C.; Nakano, S.; Sphar, T.; Tichá, J.; Williams, G. V.

2016-04-01

IAU Commission 6 ``Astronomical Telegrams'' had a single business meeting during Honolulu General Assembly of the IAU. It took place on Tuesday, 11 August 2015. The meeting was attended by Hitoshi Yamaoka (President), Daniel Green (Director of the Central Bureau for Astronomical Telegrams, CBAT, via Skype), Steven Chesley (JPL), Paul Chodas (JPL), Alan Gilmore (Canterbury University), Shinjiro Kouzuma (Chukyo University), Paolo Mazzali (Co-Chair of the Supernova Working Group), Elena Pian (Scuola Normale Superiore di Pisa), Marion Schmitz (chair IAU Working Group Designations + NED), David Tholen (University of Hawaii), Jana Ticha (Klet Observatory), Milos Tichy (Klet Observatory), Giovanni Valsecchi (INAF\\slash Italy), Gareth Williams (Minor Planet Center). Apologies: Nikolai Samus (General Catalogue of Variable Stars, GCVS).

Progress in biogas II - Biogas production from agricultural biomass and organic residues. Pt. 2. Proceedings; Progress in Biogas II - Biogasproduktion aus landwirtschaftlicher Biomasse und organischen Reststoffen. T. 2. Tagungsband

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-08-12

Within the International Congress at the University of Hohenheim (Stuttgart, Federal Republic of Germany) from 29th March to 1st April, 2011, beside numerous poster presentations the following lectures were held: (1) Coverage of digestate storage tanks: why it is necessary and technical solutions (Paolo Balsari); (2) Digestate Standard in the United Kingdom (David Collins); (3) Unraveling the causes of nitrogen losses from the bioslurry and strategies for value addition (Steven Nyanzi); (4) Biological nitrogen removal from the liquid phase of anaerobic digestate of livestock effluents and energy crops (Francesco Fatone); (5) Ammonium loss of digestate during drying (Claudia Maurer); (6) Innovative process of gaining efficient fertilizers from digestates (Daniel Schloz).

VARIACIONES SRAFFIANAS: HOMENAJE A ERNEST LLUCH

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Alfons Barceló

2006-07-01

Full Text Available No era Ernest Lluch individuo propenso a adoptar un singular libro de cabecera, ni a seguir con fidelidad las huellas de un único maestro. Pero, por supuesto, tenía su personal esquema devalores y sus escalas de preferencias. Y uno de los autores que sin discusión estaba presente en su galería privada de economistas ilustres fue Piero Sraffa (1898-1983. Creo que también habríacolocado en esa división de honor a François Quesnay, Adam Smith, David Ricardo, Karl Marx, Knut Wicksell, John M. Keynes, Joseph A.Schumpeter, Maurice H. Dobb, Wassily Leontief, John K. Galbraith, Paolo Sylos Labini y Albert O. Hirschman.

Robotic exploration of the solar system

CERN Document Server

Ulivi, Paolo

In Robotic Exploration of the Solar System, Paolo Ulivi and David Harland provide a comprehensive account of the design and managment of deep-space missions, the spacecraft involved - some flown, others not - their instruments, and their scientific results. This third volume in the series covers launches in the period 1997 to 2003 and features: - a chapter entirely devoted to the Cassini-Huygens mission to Saturn; - coverage of planetary missions of the period, including the Deep Space 1 mission and the Stardust and Hayabusa sample returns from comets and asteroids; - extensive coverage of Mars exploration, the failed 1999 missions, Mars Odyssey, Mars Express, and the twin rovers Spirit and Opportunity. The story will continue in Part 4.

1st October 2011 - President of India P. Devisingh Patil at LHC Point 2, welcomed by CERN Director-General R. Heuer.

CERN Multimedia

Maximilien Brice

2011-01-01

The Indian president, Pratibha Devising Patil, visited CERN on 1 October 2011. During her tour she saw, top right, the ALICE experiment (with from left to right Paolo Giubellino, ALICE spokesperson, Chitra Narayanan, Indian Ambassador to Switzerland, Rolf Heuer, CERN’s director-general, Christy Fernandez, secretary to the president, Rajeev Shukla, Indian minister of state for parliamentary affairs, Tapan Nayak, ALICE and VECC, and Felicitas Pauss, CERN’s head of international relations); top left, went underground with Vinod Chohan, from the Accelerator Beam Lines & Areas group, far left, and (back to camera) Steve Myers, director of accelerators and technology at CERN; bottom left, greeted Indian physicists at CERN; finally posing with Indian members of the ALICE and CMS collaborations and Indian officials.

Discussing epigenetics in Southern California: a report from the International Symposium on Epigenetic Control and Cellular Plasticity, UCI, December 15-16, 2011.

Science.gov (United States)

Rattner, Barbara P

2012-04-01

With the goal of discussing how epigenetic control and chromatin remodeling contribute to the various processes that lead to cellular plasticity and disease, this symposium marks the collaboration between the Institut National de la Santé et de la Recherche Médicale (INSERM) in France and the University of California, Irvine (UCI). Organized by Paolo Sassone-Corsi (UCI) and held at the Beckman Center of the National Academy of Sciences at the UCI campus December 15-16, 2011, this was the first of a series of international conferences on epigenetics dedicated to the scientific community in Southern California. The meeting also served as the official kick off for the newly formed Center for Epigenetics and Metabolism at the School of Medicine, UCI (http://cem.igb.uci.edu).

Cultural Alimentation in Latin America

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Freire

1973-01-01

Le Prof. Paolo Freire(nom?) a dirigé en Brésil un plan national d'alphabétisatation d'adultes. La base de sa méthode est d'essayer de ne pas rester sur la mécanique du mot, mais de le relier avec la réalité sociale et donner un réveillement critique de la conscience populaire en face de la réalité historique du pays. Il était professeur d'histoire et de philosophie de Récife, puis exilé et depuis il était prof. à Harvard, a travaillé à l'Unesco et est maintenant conseiller spécial à l'Office d'Education du centre oecuménique des églises

Francisco de Goya en San Nicolás de los Loreneses de Roma 1770

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Navarrete Prieto, Benito

2002-09-01

Full Text Available La aparición del Cuaderno Italiano de Goya y su posterior estudio por parte de Jesús Urrea, Manuela Mena, Juliet Wilson, Paolo Mangiante, Rogelio Buendía y Arturo Ansón ha venido a desvelar un periodo fascinante en la formación del joven Goya, pudiendo rastrear, no solo los elementos que constituyeron sus fuentes en el periodo de aprendizaje, sino los propios orígenes de su arte y sobre todo constituirse en instrumento para fechar y autentificar obras del artista de su época juvenil entre las que destaca el Aníbal vencedor, felizmente hallado por Urrea y con el que Goya concurrió al premio de la Academia de Parma en 1771....

Discurso e prática religiosa nas Comunidades Eclesiais de Base italianas e brasileiras: um estudo comparativo com base na teoria da mudança social de Max Weber (Speech and religious practice in the Basic Ecclesial Communities in Italy and Brazil

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Marinete Luzia Francisca de Souza

2011-12-01

Full Text Available Este estudo é uma reflexão sobre  o discurso e a prática nas comunidades Eclesiais de Base no Brasil e na Itália. Buscamos demonstrar, a partir de uma pesquisa empírica e teórica, as relações entres duas Comunidades Eclesiais de Base, a Comunidade San Paolo (Roma-IT e a Prelazia de São Félix (Mato Gross-BR, demonstrando que estas baseiam-se em dois elementos: resultam das discussões  advindas do Concílio Vaticano II e estão fortemente ligadas a seus líderes. E, ainda, que tais comunidades ligam-se por fortes laços simbólicos. Este fato permitiu-nos concluir  que a Teologia da Libertação empenhou-se em promover mudanças sociais e em criar um corpo simbólico que a corroborasse. Tais análises foram sustentadas pela teoria da transformação social de Max Weber e, ainda, pelos estudos  de Karl Mannheim e de  Glock e Stark. Palavras-chaves:Transformação social, Teologia da Libertação, prática, discurso. Abstract This study is a reflection of the discourse and practice on the Basic Ecclesial communities in Brazil and Italy. We try to show, from an empirical and theoretical research, the relations between two Christian Base Communities: the San Paolo Community (Rome – IT and the Prelature of São Félix (BR – Mato Grosso, based on two factors: the result of discussions arising out of Vatican II, and the strong link to its leaders. Such communities bind by strong symbolic ties that really allowed us to conclude that Liberation Theology endeavored to promote social changes and to create a symbolic body that corroborates it. Such analysis was supported by the theory of social transformation of Max Weber, by the studies of Karl Mannheim and Glock and Stark. Keywords: Social Transformation; Liberation Theology, Practice, Discourse.

Il paesaggio di Matera nell'interpretazione cinematografica / Matera landscape in the cinematographic interpretation

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Angelo Bencivenga

2016-05-01

Full Text Available Una definizione classica inquadra il paesaggio come natura percepita attraverso una cultura. Sulla "storicità" del paesaggio, alcuni autori hanno sottolineato la capacità del cinema di registrare le trasformazioni del territorio e allo stesso tempo di orientare lo sguardo su di esso. La Basilicata, a partire dal secondo dopoguerra, è stata terra di cinema; più di quaranta produzioni cinematografiche sono state realizzate sul suolo lucano. Una tendenza dominante, da Il Vangelo secondo Matteo di Pier Paolo Pasolini a Cristo si è fermato a Eboli di Francesco Rosi, ha messo in luce la condizione di miseria e arretratezza della Basilicata, influenzata da autori come Carlo Levi ed Ernesto De Martino. Interessante è il caso di Matera che, da espressione cinematografica di tale tendenza interpretativa, è diventata teatro di opere filmiche - come The Passion di Mel Gibson - che hanno contribuito a formare l'immagine di una città quasi mistica e culturalmente attiva. A classical definition of landscape is "nature perceived through a culture". On the "historicity" of the landscape, some authors have underlined the cinema’s capacity  to register the transformations of the territory and, at the same time, to direct the gaze on it. Since the end of the Second World War, the Basilicata region has been a film location; more than forty full length movies have been shot in Basilicata. Most of them, from The gospel according to St. Matthew by Pier Paolo Pasolini to Christ stopped at Eboli by Francesco Rosi, have shown the misery and the backwardness of Basilicata, inspired by the works of some authors as Carlo Levi and Ernesto De Martino. Matera is an interesting case study: from expression of this cinematic representation, in the last years it has become the location of some movies - like The Passion by Mel Gibson - that have had an important role in building the image of Matera as an almost mystic and culturally dynamic city.

Le celebrazioni del mondo contadino e le pratiche del teatro in ambiente naturale: un confronto

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Anna Bianchi

2013-03-01

Full Text Available This paper develops a chapter of my dissertation, L’arte del percepire: esperienze contemporanee di Teatro nella Natura in Italia (The art of perception: contemporary Italian experiences of Theatre in theNature. I propose a particular point of view over these theatre practices: I claim that they can beapproached and analytically compared to some features of rural teatrality and rituality, such asidentified by Paolo Toschi in his classical book, Le origini del teatro italiano, a ground study for understanding the connections between theatre and folklore. Actually we can identify long-lastingdevices (procession, singing, storytelling, dance, ritual which were typical of rural teatrality andrituality, and which occur, as well, in contemporary theatre practices in the nature, despite the radicaldifferences that separate popular tradition from contemporary theatre research

Care and Conversing in Dialogical Systems

DEFF Research Database (Denmark)

Steffensen, Sune Vork

2012-01-01

positions, a theory of dialogical systems is developed, on the basis of current thinking within the enactive program (e.g. De Jaegher and Di Paolo, 2007), the distributed language movement (e.g. Cowley, 2011b), and values-realizing theory (e.g. Hodges, 2009). Dialogical systems are systems of co......This article promotes a point of view on human interaction in terms of dialogical systems. The approach draws on recent, so-called third wave, developments in cognitive science. After an introduction to three waves in cognitive science, and their counterparts in linguistics, the article is placed......-present human beings engaged in interactivity that bring forth situated behavioural coordination (or a communicative, structural coupling). Dialogical systems, however, have emergent properties irreducible to individual actions or microsocial norms. Among the emergent properties one find a tendency to establish...

Leituras semióticas de Pinóquio

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Rafael Giardini Lenzi

2013-12-01

Full Text Available Esta resenha faz breve exposição do conteúdo de Pinocchio: nuove avventure tra segni e linguaggi, organizado por Paolo Fabbri e Isabella Pezzini, que apresenta dez artigos e um tautograma que tratam do tema Pinóquio, alternando entre elementos do texto original, elementos presentes em variações do romance e abordagens sobre a tradução ou a variação em si, sob a óptica da semiótica discursiva. A perseverança e forte proliferação do tema Pinóquio, originalmente ou sob outros pontos de vista trazidos pelos meios de comunicação, estabelece o texto como uma fábula da atualidade que sempre atraiu o olhar científico.

11 March 2009 - Italian Minister of Education, University and Research M. Gelmini, visiting ATLAS and CMS underground experimental areas and LHC tunnel with Director for Research and Scientific Computing S. Bertolucci. Signature of the guest book with CERN Director-General R. Heuer and S. Bertolucci at CMS Point 5.

CERN Multimedia

Maximilien Brice

2009-01-01

Members of the Ministerial delegation: Cons. Amb. Sebastiano FULCI, Consigliere Diplomatico Dott.ssa Elisa GREGORINI, Segretario Particolare del Ministro Dott. Massimo ZENNARO, Responsabile rapporti con la stampa Prof. Roberto PETRONZIO, Presidente dell’INFN (Istituto Nazionale di Fisica Nucleare) Dott. Luciano CRISCUOLI, Direttore Generale della Ricerca, MIUR Dott. Andrea MARINONI, Consulente scientifico del Ministro CERN delegation present throughout the programme: Prof. Sergio Bertolucci, Director for Research and Scientific Computing Prof. Fabiola Gianotti, ATLAS Collaboration Spokesperson Prof. Paolo Giubellino, ALICE Deputy Spokesperson, Universita & INFN, Torino Prof. Guido Tonelli, CMS Collaboration Deputy Spokesperson, INFN Pisa Dr Monica Pepe-Altarelli, LHCb Collaboration CERN Team Leader Guests in the ATLAS exhibition area: Dr Marcello Givoletti\tPresident of CAEN Dr Davide Malacalza\tPresident of ASG Ansaldo Superconductors and users: Prof. Clara Matteuzzi, LHCb Collaboration, Universita' d...

Introduzione

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Alessandro Roncaglia

2010-03-01

Full Text Available Con questo numero, Moneta e Credito riprende la sua regolare cadenza trimestrale dopo l'interruzione connessa al passaggio di proprietà dalla Banca Nazionale del Lavoro alla Associazione Paolo Sylos Labini. Abbiamo tentato di colmare tale interruzione con i numeri speciali per il 2008 e per il 2009 usciti nei mesi scorsi: nel primo caso con gli indici dei primi sessant'anni di vita delle riviste e due articoli introduttivi di ricostruzione del loro percorso (Roncaglia, 2008a e 2008b, nel secondo caso con una raccolta di articoli pubblicati negli ultimi anni su temi connessi alla crisi finanziaria ed economica che sarebbe poi esplosa e una breve introduzione per inquadrare questi contributi nel dibattito teorico più recente.   JEL Codes:  E44, G01 

Discussing epigenetics in Southern California

Science.gov (United States)

2012-01-01

With the goal of discussing how epigenetic control and chromatin remodeling contribute to the various processes that lead to cellular plasticity and disease, this symposium marks the collaboration between the Institut National de la Santé et de la Recherche Médicale (INSERM) in France and the University of California, Irvine (UCI). Organized by Paolo Sassone-Corsi (UCI) and held at the Beckman Center of the National Academy of Sciences at the UCI campus December 15–16, 2011, this was the first of a series of international conferences on epigenetics dedicated to the scientific community in Southern California. The meeting also served as the official kick off for the newly formed Center for Epigenetics and Metabolism at the School of Medicine, UCI (http://cem.igb.uci.edu). PMID:22414797

Pasolini's Edipo Re: myth, play, and autobiography.

Science.gov (United States)

Pipolo, Tony

2013-08-01

The pervasive influence of the Oedipus complex on world culture is a given, yet throughout the long history of motion pictures only one major filmmaker has tackled the literary source that inspired Freud. The film, Edipo Re, directed by Italian poet, novelist, and social and political activist Pier Paolo Pasolini, not only reconstructs the myth and adapts Sophocles' tragedy, but uses both as a basis of cinematic autobiography. This paper is a detailed analysis of the formal, stylistic, and thematic dimensions of this film, illustrating the complex manner in which Pasolini interweaves myth, play, and autobiography into a unique cinematic achievement. This analysis is followed by speculations on the implications of the film's structure and techniques and on what they reveal about Pasolini's character, his sexual profile, and the ignominious murder that ended his life.

New ideas to improve searches for μ+ → e+γ

International Nuclear Information System (INIS)

Cooper, M.D.

1997-11-01

Searching for decays that change total lepton family number is an excellent method to explore potential physics beyond the Standard Model because those processes are predicted to be zero except when new physics is present. Essentially all extensions of the Standard Model that introduce new, heavy particles predict the existence of these rare decays, though the most probable channel is highly model dependent. Recently, the prejudice has grown within the physics community that supersymmetry is an extension that is likely to be related to nature. Barbieri, Hall, and Strumia show that rare decays are signatures for grand unified supersymmetry and calculate the rates for μ + → e + γ and related processes for a wide range of parameters of these models. They conclude that μ + → e + γ has the largest rate by more than two orders of magnitude, and it ranges between the current experimental limit and 10 -14 . Hence, there is continuing interest in the community for an experiment that could have a sensitivity near 10 -14 . Lessons are drawn from the experience of the MEGA experiment in searching for μ + to e + γ. In light of that experience, some ideas are evaluated regarding new searches that might take place in the ERA of a source of low-energy muons associated with a muon collider

SDS-PAGE in conjunction with match lane statistical analysis for the detection of meat adulteration

International Nuclear Information System (INIS)

Hegazy, R.A.; Nassef, A.E.

2003-01-01

Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of seven meat types and two component mixtures of them were made. Banding patterns of resulting denstograms in conjunction with cluster analysi and match lane statistical analysis were used for the detection of meat adulteration. The use of beef as a reference meat have resulted in a clear distinction from goat, pork, chicken, turkey, camel meats and their mixture and camel meat. The use of pork meat as a reference was more assurate because of the low degrees of matching with all meats and their mixtures and consequently high abilities of differentiations. The purpose of identification. the purpose of identification of meat species arises from the desire of human, in general, to confirm what he eat ? for moslems the establisment that meat is free from pork type is most important. Another economic purpose is the detection of adulteration of valuable meat by less valuable types. Several attempts in different laboratories were done to serve this object but most of analytical techniques. Barbieri and formi (1999) were able to detect 5% of meat type in mixtures by isolelectric focusing and 1% of meat type by PCR technique in beef, pork, chicken and turkey meats. By crossover immunoelectrophoresis technique, zanon and vianello (1998) were also to detect a limit of 5% of specific meat in mixuters of beef, pork, mutton/lamb, horse and chicken meats

Paolo Lago, La nave, lo spazio e l’altro. L’eterotopia della nave nella letteratura e nel cinema

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Marina Guglielmi

2017-05-01

Full Text Available L’eterotopia, quando si radica nel progetto critico di uno studioso, può assumere la fisionomia di un “rovello” personale. Lo è stato per Michel Foucault che nel 1966 ha cristallizzato in una definizione e in una prima tassonomia i «luoghi reali fuori da tutti i luoghi» (Utopie, eterotopie, Napoli, Cronopio, 2006: 13, i contro-spazi «che si oppongono a tutti gli altri e sono destinati a cancellarli, a compensarli, a neutralizzarli o a purificarli» (ibid.: 12.

Sense-making with a little help from my friends

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Tom Froese

2012-12-01

Full Text Available The work of Ezequiel Di Paolo and Hanne De Jaegher has helped to transform the enactive approach from relative obscurity into a hotly debated contender for the future science of social cognition and cognitive science more generally. In this short introduction I situate their contributions in what I see as important aspects of the bigger picture that is motivating and inspiring them as well as the rest of this young community. In particular, I sketch some of the social issues that go beyond mere academic debate, including how the methods and assumptions that inform orthodox cognitive science are intrinsically related to the critical state of affairs in our world today. I conclude with some personal recollections in order to give an idea of the context in which their ideas, and mine as well, came to fruition.

Morning akinesia in Parkinson's disease: challenges and solutions

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Tambasco N

2016-06-01

Full Text Available Nicola Tambasco,1 Simone Simoni,1 Pasquale Nigro,1 Federico Paolini Paoletti,1 Erica Marsili,1 Paolo Calabresi1,2 1Neurology Clinic, Azienda Ospedaliera – Università di Perugia, Perugia, 2Neurophysiology Department, IRCCS Fondazione Santa Lucia, Rome, Italy Abstract: Motor complications of Parkinson's disease (PD have been reported to occur after a few years of treatment with levodopa (L-dopa. Morning akinesia is a delayed ON of the first L-dopa daily dose, occurring in almost 60% of patients on dopaminergic treatment. This is primarily a motor symptom, but has been recently recognized as being correlated with nonmotor fluctuations. Sleep disorders and gastrointestinal dysfunction might be the underlying mechanisms. Over the past 30 years, several pharmacological and nonpharmacological approaches have been investigated. Keywords: Parkinson's disease, morning akinesia, motor fluctuation, L-dopa 

Quando la libertà prevale sulla morale: la pubblicità

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Nicola Colaianni

2018-02-01

ABSTRACT: This article examines the case Sekmadienis v. Lithuania, where the European Court of human rights found that the advertisements by a clothing company, despite using models and captions referring to “Jesus” and “Mary”, did not offend public morals. Nevertheless the balancing in favour, for once, of freedom of expression is due not to a revirement but, essentially, to two factors: the advertisements neither were gratuitously offensive nor incited hatred and, on the other hand, domestic authorities did not provide sufficient justifications for why such use of religious symbols would had been contrary to public morals. Therefore, it’s an assertion not of secularism in front of religion but – the author says quoting Pier Paolo Pasolini - a new laicity, that does not compete with religion: the advertising laicity, born in middle-class entropy.

Political space and boundaries in the late medieval juridical science

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Paolo Marchetti

2006-06-01

Full Text Available In what Paolo Grossi calls «the sapiential Middle Ages» jurists engaged themselves in defining a set of rules aiming at the settlement of boundary disputes, which previously were not established by any normative text. The Corpus Iuris concerns nearly exclusively boundary disputes between private individuals. References to texts of the Roman law were meant to give ‘authority’ to resolutions often based upon customary praxis. The norms elaborated by Middle Ages jurists are thus given a formal legal shape; yet, they are linked to a perception of the boundaries between communities that was affected by the displacements, the customs, the common needs of everyday life. On the other side the existence of actual neat demarcations was linked to the exertion of certain rights and privileges rather than to an exclusive and absolute political claim.

La tutela del risparmio nel pensiero e nell'azione del Governatore Baffi (The defence of savings: Governor Baffi’s belief and achievements

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M. Sarcinelli

2013-10-01

Full Text Available Ten years after his death and twenty after his resignation from Banca d’Italia governorship, Paolo Baffi’s ideas and achievements as regards the protection of savings and the fight against a high and volatile inflation in the turbulent 1970s are reviewed. Against the backdrop of the constitutional precepts in this field, the proposals to shorten maturities and to index bond coupons, first advanced in the well known address Baffi delivered at Accademia Nazionale dei Lincei, were translated into Treasury decisions on public debt at his instigation. Moreover, in the concluding remarks he pronounced at the Banca d’Italia General Meeting of Shareholders between 1976 and 1979 there are many hints at problems and solutions that have become prominent in the 1980s and 1990s.  JEL Codes: B31, E58 

Pasolini y Zurita: torturas alimentarias

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Magda Sepúlveda Eriz

2015-12-01

Full Text Available La película Saló de Pier Paolo Pasolini y el libro Zurita de Raúl Zurita comparten la representación de la violencia sobre los cuerpos como un efecto de la alianza que se produce entre la política y la ley, propia de los estados totalitarios. En ellos, toda la política se ejerce mediante leyes que no tan solo norman los espacios públicos, sino también los privados, lo que incluye las actividades sexuales, alimentarias y de defecación, entre otras. Ambos autores discuten esta práctica de la ley ejercida en espacios cerrados. Pasolini hace del palacio que encierra a los prisioneros una metonimia de todo tipo de nación y Zurita liga los territorios de las naciones latinoamericanas a ejercicios de exterminio.

Is all Quiet on the Eastern Front? Semiosis and the Deeper Structure of the Border of Trieste

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Matteo Colombi

2011-05-01

Full Text Available The article deals with Trieste as centre of the troubled eastern Italian border. Ivan Verč claims that Trieste’s border area has been "not semiotized" by Italian culture: the complexity of what lays beyond being reduced to a generic Slavic East. This hypothesis is interpreted on the one hand on the background of Trieste’s history in the 19th and 20th century. On the other hand it is reconsidered through the reflections of the Triestine psychoanalyst Paolo Fonda: the absence of conscious semiosis is the product of intense fears and desires that pervade the construction of ethnic identities in Trieste. Fonda’s exhortation to a more balanced depressive position (Melanie Klein recalls the pleading of other intellectuals (e.g. Verč for a not naïf but dynamic concept of cultural dialogue.

Comparative Perspectives on the Changing Business of Journalism and Its Implications for Democracy

DEFF Research Database (Denmark)

Nielsen, Rasmus Kleis; Frank, Esser; David, Levy

2013-01-01

The last decade has seen tremendous change in the commercial news media that play a central role in political processes in democracies around the world, as well as considerable progress in cross-national comparative media research. But despite the impact of Daniel C. Hallin and Paolo Mancini’s book......-conceptions, and of news content). In this piece, we call for further institutionally and system-oriented mixed-methods comparative research to advance our understanding of how current changes are impacting journalism, the news media, and ultimately politics in different settings. We suggest that existing conceptions...... Comparing Media Systems, empirical research into the institutional and systemic preconditions of journalism and news production has not kept pace with the rapid changes in the media, nor with the advances made in other areas of comparative media research (such as studies of news media use, journalists’ role...

Introduzione

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Alessandro Roncaglia

2010-07-01

Full Text Available Con questo numero, Moneta e Credito prosegue la sua nuova vita dopo l’interruzione connessa al passaggio di proprietà dalla Banca Nazionale del Lavoro all’Associazione Paolo Sylos Labini. Tale interruzione è stata colmata con i numeri speciali per il 2008 e per il 2009 usciti negli ultimi mesi dell’anno scorso. Il numero speciale per il 2008 contiene gli indici dei primi sessant’anni di vita delle riviste e due articoli introduttivi di ricostruzione del loro percorso (Roncaglia, 2008a e 2008b; quello per il 2009 presenta una selezione di articoli pubblicati negli ultimi anni su temi connessi alla crisi finanziaria ed economica che sarebbe poi esplosa, con una breve introduzione per inquadrare questi contributi nel dibattito teorico più recente.  JEL Codes:  F3, G1, N1,  B5

On the performance of joint iterative detection and decoding in coherent optical channels with laser frequency fluctuations

Science.gov (United States)

Castrillón, Mario A.; Morero, Damián A.; Agazzi, Oscar E.; Hueda, Mario R.

2015-08-01

The joint iterative detection and decoding (JIDD) technique has been proposed by Barbieri et al. (2007) with the objective of compensating the time-varying phase noise and constant frequency offset experienced in satellite communication systems. The application of JIDD to optical coherent receivers in the presence of laser frequency fluctuations has not been reported in prior literature. Laser frequency fluctuations are caused by mechanical vibrations, power supply noise, and other mechanisms. They significantly degrade the performance of the carrier phase estimator in high-speed intradyne coherent optical receivers. This work investigates the performance of the JIDD algorithm in multi-gigabit optical coherent receivers. We present simulation results of bit error rate (BER) for non-differential polarization division multiplexing (PDM)-16QAM modulation in a 200 Gb/s coherent optical system that includes an LDPC code with 20% overhead and net coding gain of 11.3 dB at BER = 10-15. Our study shows that JIDD with a pilot rate ⩽ 5 % compensates for both laser phase noise and laser frequency fluctuation. Furthermore, since JIDD is used with non-differential modulation formats, we find that gains in excess of 1 dB can be achieved over existing solutions based on an explicit carrier phase estimator with differential modulation. The impact of the fiber nonlinearities in dense wavelength division multiplexing (DWDM) systems is also investigated. Our results demonstrate that JIDD is an excellent candidate for application in next generation high-speed optical coherent receivers.

Naturalness made easy: two-loop naturalness bounds on minimal SM extensions

Energy Technology Data Exchange (ETDEWEB)

Clarke, Jackson D.; Cox, Peter [ARC Centre of Excellence for Particle Physics at the Terascale,School of Physics, University of Melbourne,Melbourne, 3010 (Australia)

2017-02-24

The main result of this paper is a collection of conservative naturalness bounds on minimal extensions of the Standard Model by (vector-like) fermionic or scalar gauge multiplets. Within, we advocate for an intuitive and physical concept of naturalness built upon the renormalisation group equations. In the effective field theory of the Standard Model plus a gauge multiplet with mass M, the low scale Higgs mass parameter is a calculable function of (MS)-bar input parameters defined at some high scale Λ{sub h}>M. If the Higgs mass is very sensitive to these input parameters, then this signifies a naturalness problem. To sensibly capture the sensitivity, it is shown how a sensitivity measure can be rigorously derived as a Bayesian model comparison, which reduces in a relevant limit to a Barbieri-Giudice-like fine-tuning measure. This measure is fully generalisable to any perturbative EFT. The interesting results of our two-loop renormalisation group study are as follows: for Λ{sub h}=Λ{sub Pl} we find “10% fine-tuning” bounds on the masses of various gauge multiplets of M

Swift: 10 Years of Discovery

Science.gov (United States)

2014-12-01

The conference Swift: 10 years of discovery was held in Roma at La Sapienza University on Dec. 2-5 2014 to celebrate 10 years of Swift successes. Thanks to a large attendance and a lively program, it provided the opportunity to review recent advances of our knowledge of the high-energy transient Universe both from the observational and theoretical sides. When Swift was launched on November 20, 2004, its prime objective was to chase Gamma-Ray Bursts and deepen our knowledge of these cosmic explosions. And so it did, unveiling the secrets of long and short GRBs. However, its multi-wavelength instrumentation and fast scheduling capabilities made it the most versatile mission ever flown. Besides GRBs, Swift has observed, and contributed to our understanding of, an impressive variety of targets including AGNs, supernovae, pulsars, microquasars, novae, variable stars, comets, and much more. Swift is continuously discovering rare and surprising events distributed over a wide range of redshifts, out to the most distant transient objects in the Universe. Such a trove of discoveries has been addressed during the conference with sessions dedicated to each class of events. Indeed, the conference in Rome was a spectacular celebration of the Swift 10th anniversary. It included sessions on all types of transient and steady sources. Top scientists from around the world gave invited and contributed talks. There was a large poster session, sumptuous lunches, news interviews and a glorious banquet with officials attending from INAF and ASI. All the presentations, as well as several conference pictures, can be found in the conference website (http://www.brera.inaf.it/Swift10/Welcome.html). These proceedings have been collected owing to the efforts of Paolo D’Avanzo who has followed each paper from submission to final acceptance. Our warmest thanks to Paolo for all his work. The Conference has been made possible by the support from La Sapienza University as well as from the ARAP

Long-term survival in elderly patients with a do-not-intubate order treated with noninvasive mechanical ventilation

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Riario-Sforza GG

2011-04-01

Full Text Available Paolo Scarpazza1, Cristoforo Incorvaia2, Paolo Amboni3, Giuseppe di Franco1, Stefania Raschi1, Pierfranco Usai1, Monica Bernareggi1, Cristiano Bonacina1, Chiara Melacini1, Roberta Cattaneo1, Serena Bencini1, Chiara Pravettoni2, Gian Galeazzo Riario-Sforza2, Gianni Passalacqua4, Walter Casali11Divisione di Broncopneumotisiologia, Ospedale Civile, Vimercate, Italy; 2Pulmonary Rehabilitation, Istituti Clinici di Perfezionamento, Milan, Italy; 3Clinical Chemistry Laboratory, Ospedali Riuniti, Bergamo, Italy; 4Allergy and Respiratory Diseases, University Of Genoa, Genoa, ItalyBackground: Noninvasive mechanical ventilation (NIMV is an effective tool in treating patients with acute respiratory failure (ARF, since it reduces both the need for endotracheal intubation and the mortality in comparison with nonventilated patients. A particular issue is represented by the outcome of NIMV in patients referred to the emergency department for ARF and with a do-not-intubate (DNI status because of advanced age or excessively critical conditions. This study evaluated long-term survival in a group of elderly patients with acute hypercapnic ARF who had a DNI order and who were successfully treated by NIMV.Methods: The population consisted of 54 patients with a favorable outcome after NIMV for ARF. They were followed up for 3 years by regular control visits, with at least one visit every 4 months, or as needed according to the patient’s condition. Of these, 31 continued NIMV at home and 23 were on long-term oxygen therapy (LTOT alone.Results: A total of 16 of the 52 patients had not survived at the 1-year follow-up, and another eight patients died during the 3-year observation, with an overall mortality rate of 30.8% after 1 year and 46.2% after 3 years. Comparing patients who continued NIMV at home with those who were on LTOT alone, 9 of the 29 patients on home NIMV died (6 after 1 year and 3 after 3 years and 15 of the 23 patients on LTOT alone died (10 after 1

ALICE physicists receive 2014 Lise Meitner Prize

CERN Multimedia

Katarina Anthony

2014-01-01

On Wednesday, 3 September, four ALICE physicists were presented with the European Physical Society's 2014 Lise Meitner Prize for their outstanding contributions to nuclear physics (see here).   ALICE collaboration members Johanna Stachel (Heidelberg University, Germany), Peter Braun-Munzinger (GSI, Germany), Paolo Giubellino (INFN Turin, Italy, and CERN) and Jürgen Schukraft (CERN) were presented with their awards at a private ceremony held in the Globe of Science and Innovation. In addition to members of the ALICE collaboration, the ceremony was attended by members of the CERN Management including the Director-General, Rolf Heuer, as well as the EPS Nuclear Physics Board Chair, Douglas MacGregor, and the EPS Lise Meitner Prize Committee Chair, Victor Zamfir. For more information, please see "EPS honours CERN's heavy-ion researchers".  From left to right: Douglas MacGregor (EPS); Prize recipients Jürgen Schukraft,&a...

Fish positions relative to neighbours modulate the hydrodynamic advantages of schooling

DEFF Research Database (Denmark)

Steffensen, John Fleng

2012-01-01

) and Paolo Domenici (CNR, Italy) Schooling behaviour is a widespread phenomenon shared by a large number of fish species. One of the most common benefits of swimming in a school is the hydrodynamic and energetic advantage obtained by its members. Fish occupying non-frontal positions can benefit from the flow...... generated by the caudal movement of fish swimming in the front. While previous work has demonstrated that trailing fish show a lower tail beat frequency (TBF) than leading fish , the extent to which schooling provides hydrodynamic advantages compared to swimming alone has not been quantified. We quantified...... of distances along the direction of locomotion, spanning one body length (BL) in the front (+1 BL) and behind (-1 BL) a neighbouring fish. We found a significant reduction in the mean TBF of fish when swimming in a school versus solitary fish . Furthermore, the TBF of the focal fish decreased linearly between...

[Postpartum depression, neonatal hospitalization, and educational intervention]. [Article in Italian] • Depressione post partum, ospedalizzazione neonatale ed intervento educativo

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Melania Picciau

2014-06-01

Full Text Available Postpartum depression (PPD is a non-psychotic depressive disease with varying severity, from moderate to severe, which originates after the 4th week from giving birth. At our hospital, a clinical approach to help mothers in a delicate period of their life was performed in 2 phases, in the first week of life during hospitalization of the newborn and after the 4th-6th week after delivery. The main instrument in use for the screening of PPD and used also in our study was the Edinburgh Postnatal Depression Scale (EPDS. Results are presented concerning in particular the correlations between EPDS and variables such as maternal characteristics and lenght of neonatal hospitalization. Articoli Selezionati del Congresso “Medicina Narrativa e Comunicazione nella Pratica Clinica” · Cagliari · 14 Aprile 2014 Guest Editors: Massimiliano Zonza, Vassilios Fanos, Gian Paolo Donzelli

Il tempo perturbante di uno sguardo

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Piero Zanini

2010-06-01

Full Text Available Nell’autunno del 1973 Pier Paolo Pasolini viene invitato a partecipare ad una rubrica televisiva intitolata Io e …, nella quale intellettuali, poeti, registi, musicisti, scrittori sono chiamati a scegliere e a parlare di un’opera d’arte a cui tengono in modo particolare. Dopo un crescendo di ripensamenti intorno al tema da trattare (una pietra, un muretto, una fontana Pasolini sceglie infine di concentrare la sua attenzione sulla forma della città, a partire da due luoghi tanto a lui familiari quanto tra loro radicalmente diversi: la medievale Orte, la fascista Sabaudia. Il risultato della sua partecipazione alla trasmissione è una sorta di ‘scritto corsaro’ per immagini, Pasolini e… la forma della città1, un documento importante e complesso per comprendere la “sostanza di Pasolini” [Contini, 1988] in quel momento particolare della sua vita che sono i primi anni Settanta.

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DEFF Research Database (Denmark)

Hansen, Annette Skovsted

This paper argues that development assistance contributed to the globalization of the 20th century by financing truly global networks of people. By focusing on the networks financed by development assistance bound by the national histories of Denmark and Japan, I illustrate how the people who...... experiences of place, however, when it is often the same people who experience many different places? Along with many other so-called donors in the 1950s, Denmark and Japan chose to invest in the education of own and other nationals involved in development and thereby financed personal connections between...... individuals throughout the world. Development assistance , where there are two or three links only between a Bangladeshi farmer, a street child in Sao Paolo and the President of the United States, the Queen of Denmark, or a suburban house wife in Japan, who has never left the Osaka area, but mothered a United...

Ricerca, tutela e valorizzazione del patrimonio archeologico: opinioni a confronto / Research, protection and enhancement of archaeological heritage: comparing different point of views

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Carmelo Grasso

2016-12-01

We publish here the speeches, reviewed by the authors, presented on the 7th of April 2016 at the workshop in honor of Claudia Giontella, dedicated to the social, cultural, political and economic challenges that archeology is called to face in this new century. The first two speeches examine the Italian protection system in the light of some recent innovations: after showing the activity of the “Comando Carabinieri per la Tutela del Patrimonio Culturale”, Carmelo Grasso illustrates the creation in 2015 of a new national task force, operating in situations of natural disasters and wars (“Caschi Blu della Cultura”, while Mario Pagano evaluates the Reform of MiBACT. Then, Paolo Güll discusses theoretical and methodological issues concerning preventive archeology, and Francesca Sogliani focuses on activities that have been promoted to enhance archeological heritage in Basilicata, also in sight of Matera European Cultural Capital 2019.

Red, White and Black: Colors of Beauty, Tints of Health and Cosmetic Materials in Early Modern English Art Writing.

Science.gov (United States)

Sammern, Romana

2015-01-01

Alongside Richard Haydocke's translation of Giovanni Paolo Lomazzo's treatise on painting (1598), the article examines concepts of color concerning cosmetics, painting and complexion as they relate to aesthetics, artistic and medical practice in the sixteenth and seventeenth centuries. Beginning with white and red as ideal colors of beauty in Agnolo Firenzuola's Discourse on the beauty of women (1541), the essay places color in relation to major issues in art, medicine and empiricism by discussing beauty as a quality of humoral theory and its colors as visual results of physiological processes. Challenging the relation of art and nature, gender and production, Lomazzo's account of complexion and Haydocke's additions on cosmetic practices and face-painting provide key passages that shed light on the relation of cosmetics colors, art writing and artistic practices at the convergence of the body, art and medicine in the context of the emerging English virtuosi around 1600.

Temporary Residences: a becoming project

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Luisa Ingaramo

2012-04-01

Full Text Available Among the experimental actions fostered so far by the Compagnia di San Paolo through its Housing Program, committed in handling the complex and fragmented housing discomfort issue, the Temporary Dwellings initiative represents a unique and innovative experience, as it actually offers the chance to activate a proper managerial direction around and about the real estate development processes. In particular, the Temporary Dwellings action is marked by two key aspects: a structured co-planning vision and projects selected through a requests for proposal system. The process in the whole aims on the one hand at reaching an high transparent level of decision making , while, on the other hand, at developing a continuous and mutual monitoring and matching activity between the Housing Program and the group of cross-curricular experts teamed up in the project: technicians, designers, managers, psychologists, contractors, and the other local stakeholders.

34th UIT Heat Transfer Conference 2016

International Nuclear Information System (INIS)

2017-01-01

The annual UIT Heat Transfer Conference of the “Unione Italiana di Termofluidodinamica” aims at promoting cooperation in the field of heat transfer and thermal sciences, by bringing together scientists and engineers working in related areas. Several issues of interest are addressed, namely natural, forced and mixed convection, conduction, radiation, multi-phase fluid dynamics and interface phenomena, computational fluid dynamics, micro- and nano-scales, efficiency in energy systems, environmental technologies and buildings, heat transfer in fire engineering. The 34th UIT Conference was held in Ferrara (FE), Italy, 4–6 July, 2015 in the spaces of the Scientific and Technological Center of The University of Ferrara. The response has been enthusiastic: 61 abstracts, 36 oral and 18 poster presentations, 48 papers published on the Proceedings To encourage the debate, the Conference Program has scheduled ample poster sessions and invited lectures from the best experts in the field along with a few of the most talented researchers. Keynote Lectures were given by Professor Giovanni S. Barozzi (University of Modena), Professor Paolo Di Marco (University of Pisa) and Professor Nicola Bianco (University of Napoli Federico II). This special volume collects a selection of the scientific contributions discussed during this conference; these works give a good overview of the state-of-the art Italian research in the field of Heat Transfer related topics. I would like to thank sincerely the authors for presenting their works at the conference and in this special issue. I would also like to extend my thanks to the Scientific Committee and the authors for their accurate review process of each paper for this special issue. Special thanks go to the organizing committee. Professor Stefano Piva (president of The Organizing Committee) About UIT (Unione Italiana Termofluidodinamica) The Italian Union of Thermal-Fluid Dynamics (UIT) was founded in Bologna on December 19, 1984

Una nota sui contributi di Augusto Graziani e di Paolo Sylos Labini al dibattito sulla natura dell’offerta di moneta

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Stefano Figuera

2016-10-01

Full Text Available (What do we know about money in Italy, since 1861? Results from new time seriesThe article reconstructs yearly time series of the main monetary aggregates for Italy. It extends extant literature by considering a longer time span (covering from national unity to 2014 and more detailed disaggregation, as well as improve the quality of the series for the older period. Finally, the new series are used to estimate the long-run determinants of money demand.JEL Classification: B14, E51, E52, E58

ALICE on the move

CERN Multimedia

CERN Bulletin

2011-01-01

A new management, new modules for its sub-detectors and an increased capacity to probe the properties of the quark-gluon plasma. The new year bodes well for ALICE and ion physics as quarks and gluons prepare to unveil their most profound mysteries.   Installation of one of the new EMCal modules in the detector. Paolo Giubellino, the new ALICE spokesperson, talks with enthusiasm about what has already been done by the ALICE collaboration and what is yet to come. He has recently taken over from Jurgen Schukraft, who led the collaboration from its earliest beginnings. “We had a very exciting first year of operation, with many interesting results coming up in a very short space of time,” says Giubellino, a heavy-ion-physics expert from the Italian National Institute for Nuclear Physics (see box for details). “The Christmas technical stop wasn’t a break for us as we upgraded the detector, completing the installation of the electromagnetic calorimeter (E...

Augmenting painted architectures for communicating cultural heritage

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Alberto Sdegno

2015-07-01

Full Text Available The paper presents a research under development at the University of Trieste to analyze a painted architecture by Paolo Veronese and to present the results using AR systems (Augmented Reality Systems. The canvas was painted in 1573 and it is now at the Gallerie dell’Accademia Museum in Venice. The aim of the research was to transform a two-dimensional work of art in a three dimensional one, allowing all the visitors of a museum to enter the space of the representation and perceive it in a more direct way. After the geometrical analysis of the picture, we started the digital restitution of the perspective references and proceed to model the virtual scene using Boolean primitives and applying all the textures to render the scene in a very realistic way. The further step was to convert the model into a dynamic form with AR algorithms and associate it with spatial references to allow users to do a virtual experience of it.

Factors influencing choice of chemotherapy in metastatic colorectal cancer (mCRC

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Rossi L

2013-11-01

Full Text Available Luigi Rossi, Foteini Vakiarou, Federica Zoratto, Loredana Bianchi, Anselmo Papa, Enrico Basso, Monica Verrico, Giuseppe Lo Russo, Salvatore Evangelista, Guilia Rinaldi, Francesca Perrone-Congedi, Gian Paolo Spinelli, Valeria Stati, Davide Caruso, Alessandra Prete, Silverio TomaoDepartment of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, ItalyAbstract: Management of metastatic colorectal cancer requires a multimodal approach and must be performed by an experienced, multidisciplinary expert team. The optimal choice of the individual treatment modality, according to disease localization and extent, tumor biology, and patient clinical characteristics, will be one that can maintain quality of life and long-term survival, and even cure selected patients. This review is an overview of the different therapeutic approaches available in metastatic colorectal cancer, for the purpose of defining personalized therapeutic algorithms according to tumor biology and patient clinical features.Keywords: metastatic colorectal cancer, patient clinical features, tumor biology, multidisciplinary approach

Note & Recensioni

Directory of Open Access Journals (Sweden)

2014-12-01

Full Text Available VolumiVito Campanelli, Web Aesthetics. How Digital Media Affect Culture and Society; Id., Remix It Yourself. Analisi socio-estetica delle forme comunicative del Web [Emanuele Crescimanno] • Jean-François Bordron, Image et vérité. Essais sur les dimensions iconiques de la connaissance [Veronica Estay Stange] • Stéphane Dumas, Les peaux créatrices – Esthétique de la sécrétion [Marc-Vincent Howlett]NoteQuidam veritatis effectus. A proposito di A Plea for Balance in Philosophy. Essays in honour of Paolo Parrini [Fabrizio Desideri] • A Single Face to Capture the Whole World: Literary Shapes and Shadows. An Interview With Tolm Coibin [Fabrizia Abbate] •Convegno Le sensible a l’oeuvre: savoirs du corps entre esthetique et neurosciences, Parigi, 15 Maggio 2014 [Jessica Murano] 

The European Physical Society Conference on High Energy Physics

Science.gov (United States)

2017-07-01

The European Physical Society Conference on High Energy Physics (EPS- HEP) is one of the major international conferences that review the field. It takes place every other year since 1971. It is organized by the High Energy and Particle Physics Division of the European Physical Society in cooperation with an appointed European Local Institute of Research or an internationally recognized University or Academy Body. EPS-HEP 2017 was held on 5-12 July in Venice, Italy at Palazzo del Cinema and Palazzo del Casinò, located in the Lido island. The conference has been organized by the Istituto Nazionale di Fisica Nucleare (INFN) and by the Department of Physics and Astronomy of the University of Padova. Editorial Board: Paolo Checchia, Mauro Mezzetto, Giuseppina Salente, Michele Doro, Livia Conti, Caterina Braggio, Chiara Sirignano, Andrea Dainese, Martino Margoni, Roberto Rossin, Pierpaolo Mastrolia, Patrizia Azzi, Enrico Conti, Marco Zanetti, Luca Martucci, Sofia Talas Lucano Canton.

Tendenze interpuntorie in giovani narratori

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Silvia Spinelli

2016-12-01

Full Text Available Il saggio si concentra sull’analisi dei fenomeni interpuntori all’interno di alcuni romanzi scritti da giovani autori italiani e pubblicati dopo l’anno duemila: 100 colpi di spazzola prima di andare a dormire, di Melissa P. (2003, La ragazza dei miei sogni di Roberto Dimitri (2007, La solitudine dei numeri primi di Paolo Giordano (2008, La Panzanella di Giulia Villoresi (2009, Acciaio di Silvia Avallone (2010 e Troppa umana speranza di Alessandro Mari (2011. L’analisi comparata dei romanzi sotto il profilo interpuntorio consente di mettere in luce alcuni aspetti interessanti: da un lato, la vicinanza con altre forme di scrittura (prevalentemente giornalistica attraverso l’impiego prevalente di punto fermo e virgola; dall’altro, la buona tenuta di alcuni elementi interpuntori caduti in disuso altrove ma qui ampiamente presenti, come il punto e virgola. Risulta, infine, ancora più interessante notare come tali utilizzi siano trasversali e riguardino l’intero corpus: non vi sono, infatti, distinzioni legate ai sottogeneri di appartenenza dei romanzi.

Aux origines de la science moderne

CERN Document Server

Rossi, Paolo

1999-01-01

Aux origines de la science moderne. " Lorsque l'on aborde l'étude d'une pensée qui n'est plus la nôtre, il est important de chercher à oublier ce que nous savons ou croyons savoir. " Pour appréhender cette période fondatrice que fut la Révolution scientifique du XVIIe siècle en Europe, Paolo Rossi nous replonge dans des atmosphères intellectuelles et des modes de pensée depuis longtemps disparus. Des secrets hermétiques aux calculs mathématiques, de la magie au magnétisme et des cabinets de curiosité aux premières académies des sciences défilent ainsi des notions et des individus qui, remis en toute simplicité dans le contexte de leur époque, retrouvent une épaisseur et un sens nouveaux. Ainsi racontée sous la forme d'une histoire des idées, l'histoire des sciences devient accessible à tous.

A First

CERN Multimedia

2004-01-01

The first International Grid Networking Workshop (GNEW2004) was held at CERN from March 15 to 16. The workshop was jointly organised by CERN/DataTAG, DANTE, INRIA and TERENA in Europe, ESnet and Internet2 in the USA and was sponsored by Cisco Systems. 81 people from 55 different academic institutes and 10 representatives of 7 private sector companies took part in the GNEW2004 workshop. Some of the members of the DataTAG Project team with an American colleague. From left to right: Martin Fluckiger, Stan Cannon, Paolo Moroni, Sylvain Ravot (Caltech), Elise Guyot, Daniel Davids, Olivier Martin, Rosy Mondardini and Edoardo Martelli. "The main lesson learnt from the workshop was that the traditional Internet-type shared packet switched network infrastructures are unlikely to be sufficient to meet the needs of future, data-intensive Grids such as the one CERN and its partners are developing for LHC Computing Grid (LCG). So-called "end to end" solutions, similar to those for telephone networks, using optically swi...

Indian President visits CERN

CERN Multimedia

Katarina Anthony

2011-01-01

On 1 October, her Excellency Mrs Pratibha Devisingh Patil, President of India, picked CERN as the first stop on her official state visit to Switzerland. Accompanied by a host of Indian journalists, a security team, and a group of presidential delegates, the president left quite an impression when she visited CERN’s Point 2!   Upon arrival, Pratibha Patil was greeted by CERN Director General Rolf Heuer, as well as senior Indian scientists working at CERN, and various department directors. After a quick overview of the Organization, Rolf Heuer and the President addressed India’s future collaboration with CERN. India is currently an Observer State of the Organization, and is considering becoming an Associate Member State. A short stop in LHC operations gave Steve Myers and the Accelerator team the opportunity to take the President on a tour through the LHC tunnel. From there, ALICE’s Tapan Nayak and Spokesperson Paolo Giubellino took Pratibha Patil to the experiment&am...

ALICE’s wonderland reveals the heaviest antimatter ever observed

CERN Multimedia

CERN Bulletin

2011-01-01

Producing and observing antiparticles is part of everyday life for many physics laboratories around the world, including CERN. However, recreating and observing the anti-nuclei of complex atoms is a much more difficult task. Analysing data collected in a run of just one month, ALICE has recently found evidence of the formation of four anti-nuclei of Helium 4, the heaviest antimatter ever created in a laboratory.   The STAR experiment at RHIC came first and published the result in March: they presented evidence of 18 anti-nuclei of Helium 4 collected over several years of data taking. “ALICE came second but it's amazing to see how fast the results came,” exclaims Paolo Giubellino, the experiment’s spokesperson. “We were able to confirm the observation of 4He anti-nuclei with data collected in November 2010.” Scientists agree on the fact that antimatter was created in the Big Bang together with matter. However, today we do not observe antimatter outsid...

FUTURE PERSPECTIVES IN MELANOMA RESEARCH. Meeting report from the “Melanoma Research: a bridge from Naples to the World. Napoli, December 5th–6 th2011”

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Ascierto Paolo A

2012-07-01

Full Text Available Abstract After more than 30 years, landmark progress has been made in the treatment of cancer, and melanoma in particular, with the success of new molecules such as ipilimumab, vemurafenib and active specific immunization. After the first congress in December 2010, the second edition of “Melanoma Research: a bridge from Naples to the World” meeting, organized by Paolo A. Ascierto (INT, Naples, Italy, Francesco M. Marincola (NIH, Bethesda, USA, and Nicola Mozzillo (INT, Naples, Italy took place in Naples, on 5–6 December 2011. We have identified four new topics of discussion: Innovative Approaches in Prevention, Diagnosis and Surgical Treatment, New Pathways and Targets in Melanoma: An Update about Immunotherapy, and Combination Strategies. This international congress gathered more than 30 international faculty members and was focused on recent advances in melanoma molecular biology, immunology and therapy, and created an interactive atmosphere which stimulated discussion of new approaches and strategies in the field of melanoma.

Future perspectives in melanoma research. Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6th-7 th2010"

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Maio Michele

2011-03-01

Full Text Available Abstract Progress in understanding the molecular basis of melanoma has made possible the identification of molecular targets with important implications in clinical practice. In fact, new therapeutic approaches are emerging from basic science and it will be important to implement their rapid translation into clinical practice by active clinical investigation. The first meeting of Melanoma Research: a bridge Naples-USA, organized by Paolo A. Ascierto (INT, Naples, Italy and Francesco Marincola (NIH, Bethesda, USA took place in Naples, on 6-7 December 2010. This international congress gathered more than 30 international and Italian faculty members and was focused on recent advances in melanoma molecular biology, immunology and therapy, and created an interactive discussion across Institutions belonging to Government, Academy and Pharmaceutical Industry, in order to stimulate new approaches in basic, translational and clinical research. Four topics of discussion were identified: New pathways in Melanoma, Biomarkers, Clinical Trials and New Molecules and Strategies.

REFLEXÕES TEÓRICO-METODOLÓGICAS SOBRE A CIÊNCIA JURÍDICA E SEU OBJETO / THEORETICAL AND METHODOLOGICAL REFLECTIONS ON JURISPRUDENCE AND HIS SUBJECT

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Luis Fernando Sgarbossa

2015-04-01

Full Text Available The present article proposes to problematize, from an interdisciplinary dialog that focuses on the fields of Anthropology, History and Sociology, the object and the methods of contemporary Jurisprudence, looking for the redeeming of the value of thoughts from authors such as Eugen Ehrlich and Julius Hermann Von Kirchmann. The article makes some critical reflections on the reductionist conception of law based on positivism, in legalism and statism, advocating a broad concept of law, recognized as a rich human and social phenomenon. On the basis of the thought of Paolo Grossi, it proposes a ransom of ordinamental vision of law, in place of merely compulsory existing conception. The study presents a criticism to the purely technological approach of law, for the sake of a methodological reset that boosts the juridical science, and argues that the withdrawal of myths, as the legal monism, may contribute to the future Jurisprudence not to succumb in front of the strict positivism, the officialism and the strict technicality.

The Metaphoros metamorphosis

CERN Multimedia

Anaïs Schaeffer

2012-01-01

In the last issue of the Bulletin, the Director-General announced the name of the winner of the architectural competition for the design of the sections of the CERN site adjacent to the route de Meyrin. In this issue, we invite you to take a detailed look at the winning project.   The route de Meyrin, between the Globe (on the right) and the Reception (behind the giant screen), as designed by Studio Bürgi. (Photo: Studio Bürgi sis - Camorino). "Metaphoros" is the name of the winning project submitted by the Ticino architects' office Studio Bürgi in the competition for the design of the sections of the CERN site adjacent to the route de Meyrin. “Metaphoros is derived from the Greek,” explains Paolo Bürgi, the landscape architect who heads the project. “It conveys the idea of transport, travel and communication, which are some of CERN’s defining characteristics!” The aim of the Meta...

Discovery Mondays: 'Separating science from fiction'

CERN Multimedia

2006-01-01

Photo credit: ESA/NASA, the AVO project and Paolo PadovaniDoes the imaginary word of fiction always end up becoming scientific reality? What futuristic visions can we extrapolate from today's technologies? Here is a short quiz to test your knowledge. Can YOU tell truth from fiction? True False The laser swords featuring in the Star Wars films really exist. Time travel is possible using black holes. You could eat a cake of antimatter. Levitation vehicles really exist. Dan Brown is a space alien. How can you distinguish truth from fiction, dreams from reality, real science and technology from the sci-fi fantasies so realistically described in novels, television and cinema? You are invited to come and discuss these questions at a Discovery Monday at the very frontiers of science..... Join us at Microcosm (Reception, Building 33, Meyrin site), on Monday, 4 September from 7:30 p.m. to 9 p.m. Entrance Free The event will be conducted in French. http://www.cern.ch/LundisDecouverte/ ...

GIANFRANCO BETTETINI, Il timpano dell’occhio. Gli intrecci e i giochi dei suoni e delle immagini, Milano, Bompiani, 2009

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Alessandro Bratus

2013-12-01

Full Text Available Il timpano dell’occhio di Gianfranco Bettetini è uno studio dedicato all’analisi semiotica dei testi audiovisivi. Nel volume l’autore si propone di indagare gli effetti che l’azione «strutturalmente sinergica e compatta» (p. 9 di suono e immagine produce sullo spettatore. Lungo tale percorso, Bettetini affronta un nodo cruciale degli studi attuali sulla comunicazione audiovisiva, offrendo allo stesso tempo un prezioso compendio della letteratura semiotica sull’argomento. Nella prima parte del volume lo studioso definisce le linee essenziali di un nuovo approccio metodologico che integra, con la sociologia e la psicologia, il quadro delle discipline che si sono occupate sistematicamente di analisi del testo filmico dal secondo dopoguerra in avanti. Nella seconda parte l’autore prende in esame quattro lungometraggi: Caterina va in città (2003 di Paolo Virzì, Notturno Bus (2007 di Davide Marengo, Il flauto magico (2007 di Kenneth Branagh e La fine del mondo – Ministoria della musica in un tempo (1969 dello stesso Bettetini.

Particle physics seminar: Muon radiography of volcanoes and the MU-RAY project

CERN Multimedia

Université de Genève

2011-01-01

UNIVERSITE DE GENEVE Ecole de physique Département de physique nucléaire et corspusculaire 24, Quai Ernest-Ansermet 1211 GENEVE 4 Tél: (022) 379 62 73 Fax: (022) 379 69 92   Wednesday 25  May 2011 PARTICLE PHYSICS SEMINAR at 17.00 hrs – Stückelberg Auditorium Muon radiography of volcanoes and the MU-RAY project Par Prof. Paolo Strolin, Università Federico II and INFN, Napoli Thanks to their penetration power, high energy muons generated in the interactions of cosmic rays with the Earth’s atmosphere offer the possibility to perform “muon radiographies” of geological structures and in particular volcanoes. The principle is similar to that of the imaging of the interior of human body through the observation of the absorption of X rays. Muon radiography has been first applied in 1970 to the search of unknown burial chambers in the Chefren’s pyramid. In the years 2000, the technique has been ...

Selected Abstracts of the 2nd International Workshop “Intensive Care of the Newborn”; Verona (Italy; March 9-10, 2018

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--- Various Authors

2018-03-01

Full Text Available Selected Abstracts of the 2nd International Workshop “Intensive Care of the Newborn”; Verona (Italy; March 9-10, 2018CONGRESS PRESIDENTPaolo Biban  Guest Editor: Paolo BibanABS 1. DOES DELAYED CORD CLAMPING (DCC AFFECT UMBILICAL CORD pH IN PRETERM INFANTS? • V.M. Samedi, L. Irvine, S. Thomas, D. Kowal, J. Rabi, A. Stritzke, N. Singhal, A. Abou MehremABS 2. SNAP-PE SCORE. MORBIDITY AND MOR­TALI­TY INDEX IN NICUs • A. Konstantinidi, R. Sokou, S. Parastatidou, A. Tsantes, N. IacovidouABS 3. EARLY PERINATAL INTERVENTIONS IM­PROVES NEONATAL OUTCOMES • A. Ansary, R. Lee, S. KinmondABS 4. DILATED CARDIOMYOPATHY AND VITAMIN D DEFICIENCY: CASE REPORT IN A PRETERM INFANT • A. Proto, S. Fiocchi, I. Gatelli, L. Ilardi, S. MartinelliABS 5. SURVEY ON PERINATAL PALLIATIVE CARE ACROSS ITALY: PRELIMINARY RESULTS • M.E. Cavicchiolo, F. Rusalen, F. Benini, P. LagoABS 6. PLASMA ERYTHROPOIETIN AND FETO-NEONATAL ASPHYXIA IN TERM AND PRETERM NEWBORNS • F. Dituri, L. Orfeo, A. Di PaoloABS 7. A CHALLENGING CASE OF CONGENITAL INFANTILE FIBROSARCOMA • A. Ganarin, F. DeCorti, P. Dall’Igna, N. Doglioni, A. Berizzi, G. Bisogno, E. Baraldi, P.G. GambaABS 8. BIRTH ASPHYXIA IN LIMITED-RESOURCE SETTINGS: ASSOCIATED FACTORS AND OUT­COMES IN RURAL AFGHANISTAN • R. Baiocchi, M. Usuelli, P. Crosignani, E. Bruni, K. Picucci, M. Valenti, M. Langer, G. StradaABS 9. NEONATAL HEMORRHAGE FOLLOWING MA­TER­NAL LOW MOLECULAR WEIGHT HEPA­RIN (LMWH ADMINISTRATION • A. Konstantinidi, R. Sokou, S. Parastatidou, G. Patsouras, E. Isaakidou, K. Lampropoulou, K. Adamopoulos, A. Tsantes, N. IacovidouABS 10. NEONATAL/INFANTILE PINOCYTOSIS. AN UN­USU­AL CASE OF HAEMOLYTIC ANEMIA • R. Sokou, G. Patsouras, K. Lampropoulou, E. Tavoulari, K. Adamopoulos, M. Theodoraki, M. Kollia, A. KonstantinidiABS 11. THROMBOCYTOSIS IN NEONATES WITH NEONATAL ABSTINENCE SYNDROME THAT WERE HOSPITALIZED AT THE NICU OF GENERAL HOSPITAL OF NIKAIA • R. Sokou, E. Isaakidou, G. Patsouras, K

New ribosome-inactivating proteins with polynucleotide:adenosine glycosidase and antiviral activities from Basella rubra L. and bougainvillea spectabilis Willd.

Science.gov (United States)

Bolognesi, A; Polito, L; Olivieri, F; Valbonesi, P; Barbieri, L; Battelli, M G; Carusi, M V; Benvenuto, E; Del Vecchio Blanco, F; Di Maro, A; Parente, A; Di Loreto, M; Stirpe, F

1997-12-01

New single-chain (type 1) ribosome-inactivating proteins (RIPs) were isolated from the seeds of Basella rubra L. (two proteins) and from the leaves of Bougainvillea spectabilis Willd. (one protein). These RIPs inhibit protein synthesis both in a cell-free system, with an IC50 (concentration causing 50% inhibition) in the 10(-10) M range, and by various cell lines, with IC50S in the 10(-8)-10(-6) M range. All three RIPs released adenine not only from rat liver ribosomes but also from Escherichia coli rRNA, polyadenylic acid, herring sperm DNA, and artichoke mottled crinkle virus (AMCV) genomic RNA, thus being polynucleotide:adenosine glycosidases. The proteins from Basella rubra had toxicity to mice similar to that of most type 1 RIPs (Barbieri et al., 1993, Biochim Biophys Acta 1154: 237-282) with an LD50 (concentration that is 50% lethal) Bougainvillea spectabilis had an LD50 > 32 mg.kg-1. The N-terminal sequence of the two RIPs from Basella rubra had 80-93% identity, whereas it differed from the sequence of the RIP from Bougainvillea spectabilis. When tested with antibodies against various RIPs, the RIPs from Basella gave some cross-reactivity with sera against dianthin 32, and weak cross-reactivity with momordin I and momorcochin-S, whilst the RIP from Bougainvillea did not cross-react with any antiserum tested. An RIP from Basella rubra and one from Bougainvillea spectabilis were tested for antiviral activity, and both inhibited infection of Nicotiana benthamiana by AMCV.

Performance and Metabolic Demand of a New Repeated-Sprint Ability Test in Basketball Players: Does the Number of Changes of Direction Matter?

Science.gov (United States)

Zagatto, Alessandro M; Ardigò, Luca P; Barbieri, Fabio A; Milioni, Fabio; Dello Iacono, Antonio; Camargo, Bruno H F; Padulo, Johnny

2017-09-01

Zagatto, AM, Ardigò, LP, Barbieri, FA, Milioni, F, Dello Iacono, A, Camargo, BHF, and Padulo, J. Performance and metabolic demand of a new repeated-sprint ability test in basketball players: does the number of changes of direction matter? J Strength Cond Res 31(9): 2438-2446, 2017-This study compared 2 repeated-sprint ability (RSA) tests in basketball players. Both tests included 10 × 30-m sprints, with the difference that the previously validated test (RSA2COD) featured 2 changes of direction (COD) per sprint, whereas the experimental test (RSA5COD) featured 5 CODs per sprint. Test performances and metabolic demands were specifically assessed in 20 basketball players. First, RSA5COD test-retest reliability was investigated. Then, RSA2COD, RSA5COD sprint times, peak speeds, oxygen uptake (V[Combining Dot Above]O2) and posttest blood lactate concentration [La] were measured. The RSA5COD results showed to be reliable. RSA2COD performance resulted better than the RSA5COD version (p 0.05). Over whole bout, the RSA2COD was more demanding than the RSA5COD, considering overall metabolic power requirement (i.e., VO2-driven + [La]-driven components). Given that RSA5COD (a) mimics real game-play as sprint distance and action change frequency/direction and (b) has the same metabolic expenditure per task completion as metabolic cost, RSA5COD is a valuable option for players and coaches for training basketball-specific agility and assessing bioenergetic demands.

Treatment of secondary hyperparathyroidism: the clinical utility of etelcalcetide

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Cozzolino M

2017-06-01

Full Text Available Mario Cozzolino,1 Andrea Galassi,1 Ferruccio Conte,1 Michela Mangano,1 Luca Di Lullo,2 Antonio Bellasi1,3 1Department of Health Sciences, Renal Division, University of Milan, ASST Santi Paolo e Carlo, San Paolo Hospital, Milan, 2U.O.C. Nefrologia e Dialisi, Ospedale L. Parodi Delfino, Colleferro, Roma, 3Sant’Anna Hospital, ASST-Lariana, Como, Italy Abstract: Secondary hyperparathyroidism (SHPT, a very frequent, severe, and worsening complication of chronic kidney disease, is characterized by high serum parathyroid hormone (PTH, parathyroid gland hyperplasia, and disturbances in mineral metabolism. Clinically, SHPT shows renal osteodystrophy, vascular calcification, cardiovascular damage, and fatal outcome. Calcium-sensing receptor (CaSR is the main physiological regulator of PTH secretion; its activation by calcium rapidly inhibits PTH. Another important player in regulating mineral metabolism is vitamin D receptor (VDR, which is under the influence of vitamin D and influences the intestinal absorption of calcium and phosphate, PTH gene expression, and bone calcium mobilization. Serum phosphate levels influence fibroblast growth factor 23 (FGF-23 production, a phosphatonin that modulates serum phosphate reabsorption, PTH synthesis, and vitamin D production. Current therapeutic approaches consist of 1 phosphate intake control by diet or phosphate binders, 2 vitamin D by VDR activation, and 3 calcimimetic agents that activate CaSR. Recently, a new long-acting peptide (etelcalcetide belonging to the calcimimetics class was approved for intravenous use in hemodialysis patients with SHPT. Etelcalcetide binds directly to CaSR, by a sulfide bond, inhibiting the production and secretion of PTH by parathyroid glands. After intravenous administration in rats, etelcalcetide is quickly distributed to the tissues and eliminated by kidneys, while in uremic animals the nonrenal excretion is only 1.2%. In hemodialysis patients, the treatment itself is the

Unknown Angels by Giuseppe Groppelli in Zadar and the Former Altar of St Anastasia in the Cathedral

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Damir Tulić

2016-01-01

. Giuseppe and his younger brother, Paolo Groppelli, led the family workshop from 1708, producing and signing sculptures together. Therefore, the newly discovered statues produced by Giuseppe are a significant contribution to his personal 174 Damir Tulić: Nepoznati anđeli Giuseppea Groppellija u Zadru... Ars Adriatica 6/2016. (155-174 oeuvre. It is difficult to distinguish between his statues and those by his brother, but it is generally believed that Paolo was a better artist. It is therefore important to compare the two sculptures, as they are believed to have been made independently. Paolo’s statue of Our Lady of the Rosary (1708 was originally located in the former Benedictine church of Santa Croce at Giudecca in Venice, and acquired early in the 19th century for the parish church of Veli Lošinj. If one compares the phisiognomy of the Christ Child by Paolo to that of Giuseppe’s signed sculpture of angel-putto in Zadar, one can observe considerable similarities (Figs. 5 and 6. However, Paolo’s sculptures are somewhat subtler and softer than Giuseppe’s. The workshop of Giuseppe and Paolo Gropelli has also been credited with two large marble angels on the main altar of the parish church in Concadirame near Treviso, as they show great similarity in style to the angels in Ljubljana’s cathedral, made around 1710 (Figs. 7, 8, 9, and 10. The oeuvre of Giuseppe and Paolo Gropelli can also be extended to two kneeling marble angels at the altar of the Holy Sacrament in the Venetian church of Santa Maria Formosa, with their marble surface somewhat damaged (Figs. 11 and 12. Coming back to the former main altar in Zadar’s church of St Donatus, it should be emphasized that it was erected following the last will of Archbishop Vettore Priuli (1688-1712, that contains a clearly expressed desire that the altar should be decorated as lavishly as possible. As the construction contract has been lost and the appearance of the altar remains unknown, it can only be supposed what

Algebraic diagrammatic construction formalism with three-body interactions

Science.gov (United States)

Raimondi, Francesco; Barbieri, Carlo

2018-05-01

Background: Self-consistent Green's function theory has recently been extended to the basic formalism needed to account for three-body interactions [Carbone, Cipollone, Barbieri, Rios, and Polls, Phys. Rev. C 88, 054326 (2013), 10.1103/PhysRevC.88.054326]. The contribution of three-nucleon forces has so far been included in ab initio calculations on nuclear matter and finite nuclei only as averaged two-nucleon forces. Purpose: We derive the working equations for all possible two- and three-nucleon terms that enter the expansion of the self-energy up to the third order, thus including the interaction-irreducible (i.e., not averaged) diagrams with three-nucleon forces that have been previously neglected. Methods: We employ the algebraic diagrammatic construction up to the third order as an organization scheme for generating a nonperturbative self-energy, in which ring (particle-hole) and ladder (particle-particle) diagrams are resummed to all orders. Results: We derive expressions of the static and dynamic self-energy up to the third order, by taking into account the set of diagrams required when either the skeleton or nonskeleton expansions of the single-particle propagator are assumed. A hierarchy of importance among different diagrams is revealed, and a particular emphasis is given to a third-order diagram [see Fig. 2(c)] that is expected to play a significant role among those featuring an interaction-irreducible three-nucleon force. Conclusion: A consistent formalism to resum at infinite order correlations induced by three-nucleon forces in the self-consistent Green's function theory is now available and ready to be implemented in the many-body solvers.

Materials and structures technology insertion into spacecraft systems: Successes and challenges

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Rawal, Suraj

2018-05-01

Over the last 30 years, significant advancements have led to the use of multifunctional materials and structures technologies in spacecraft systems. This includes the integration of adaptive structures, advanced composites, nanotechnology, and additive manufacturing technologies. Development of multifunctional structures has been directly influenced by the implementation of processes and tools for adaptive structures pioneered by Prof. Paolo Santini. Multifunctional materials and structures incorporating non-structural engineering functions such as thermal, electrical, radiation shielding, power, and sensors have been investigated. The result has been an integrated structure that offers reduced mass, packaging volume, and ease of integration for spacecraft systems. Current technology development efforts are being conducted to develop innovative multifunctional materials and structures designs incorporating advanced composites, nanotechnology, and additive manufacturing. However, these efforts offer significant challenges in the qualification and acceptance into spacecraft systems. This paper presents a brief overview of the technology development and successful insertion of advanced material technologies into spacecraft structures. Finally, opportunities and challenges to develop and mature next generation advanced materials and structures are presented.

The XX century architectural heritage in the Marche region. The Masters’ drawings and designs.

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Ramona Quattrini

2010-12-01

Full Text Available In the history of architecture, Marche is often considered as a region that did not take part in the big developments of national architecture. Hence it’s meaningful to examine the architectonic events of the Region in the XX century and how much the Marche region has been the object of work by the great masters of the past century. A list of architects - called ‘masters’ – has been selected: Franco Albini, Gae Aulenti, Carlo Aymonino, Ernesto Basile, BBPRGuido Canella, Giancarlo De Carlo, Luigi Figini, Massimiliano Fuksas, Roberto Gabetti, Ignazio Gardella, Giorgio Grassi, Vittorio Gregotti, Adalberto Libera, Giovanni Michelucci, Gaetano Minnucci, Carlo Mollino, Luigi Moretti, Pier Luigi Nervi, Giuseppe Pagano, Edoardo Persico, Marcello Piacentini, Renzo Piano, Gio Ponti, Paolo Portoghesi, Franco Purini, Ludovico Quaroni, Mario Ridolfi, Aldo Rossi, Giuseppe Samonà, Antonio Sant’Elia; Alberto Sartoris, Carlo Scarpa, Giuseppe Terragni, Gino Valle, Vittoriano Viganò, Marco Zanuso, The research is a meaningful census of the works of the 20th century, whether they have been realized or not (projects, competitions, studies etc. and assigned to the masters listed above.

Venous and arterial thrombosis: Two aspects of the same disease?

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Paolo Prandoni

2009-01-01

Full Text Available Paolo PrandoniDepartment of Cardiothoracic and Vascular Sciences, Thromboembolism Unit, University Hospital of Padua Padua, ItalyAbstract: An increasing body of evidence suggests the likelihood of a link between venous and arterial thrombosis. The two vascular complications share several risk factors, such as age, obesity, diabetes mellitus, blood hypertension, hypertriglyceridemia, and metabolic syndrome. Moreover, there are many examples of conditions accounting for both venous and arterial thrombosis, such as the antiphospholipid antibody syndrome, hyperhomocysteinemia, malignancies, infections, and the use of hormonal treatment. Finally, several recent studies have consistently shown that patients with venous thromboembolism are at a higher risk of arterial thrombotic complications than matched control individuals. We, therefore, speculate the two vascular complications are simultaneously triggered by biological stimuli responsible for activating coagulation and inflammatory pathways in both the arterial and the venous system. Future studies are needed to clarify the nature of this association, to assess its extent, and to evaluate its implications for clinical practice.Keywords: venous thromboembolism, deep vein thrombosis, pulmonary embolism, myocardial infarction, ischemic stroke, atherosclerosis

Anonimi, “Ges al meu grat non sui joglar” (BdT 461.126, “Per zo no·m voil desconortar” (BdT 461.193, “Va, cobla: al Juge de Galur” (BdT 461.246, “Seigner Juge, ben aug dir a la gen” (BdT 461.217, “Ges per li diz non er bons prez sabuz” (BdT 461.133

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Giuseppe Noto

2012-09-01

Full Text Available My paper provides a new critical edition, with critical apparatus, comment and translation of a set of anonymous ‘coblas’, copied as a sequence in the anthology present at ff. 55-66 in chansonnier P: BdT 461.126; BdT 461.193; BdT 461.246; BdT 461.217; BdT 461.133 (all of which are unica. I will examine in particular the attributions suggested so far for one or more of these ‘coblas’ (a name that has frequently been put forward is that of Paolo Lanfranchi da Pistoia, author of the sonnet in ‘cobla’ form copied in P immediately preceding the poems discussed here and address the hypothesis put forward by several scholars (and upheld with convincing evidence by Stefano Asperti that the sequence under consideration points to the strong presence of a Tuscan tradition in chansonnier P, clearly contributing, among other things, to outline a “fundamental coherence” (Asperti between some aspects of Dante’s literary culture and this particular songbook.

The opioid overdose epidemic: opportunities for pharmacists

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Wu LT

2017-07-01

Full Text Available Li-Tzy Wu,1–4 Udi E Ghitza,5 Anne L Burns,6 Paolo Mannelli,1 1Department of Psychiatry and Behavioral Sciences, 2Department of Medicine, 3Duke Clinical Research Institute, Duke University School of Medicine, 4Center for Child and Family Policy, Sanford School of Public Policy, Duke University, Durham, NC, 5Center for Clinical Trials Network, National Institute on Drug Abuse, Bethesda, MD, 6American Pharmacists Association, Washington, DC, USA The USA is experiencing an opioid overdose epidemic. It has been driven largely by prescription opioids and intensified by a surge of illicit opioids (e.g., heroin and fentanyl.1,2 Drug-involved overdose, mainly opioids (e.g., prescription opioids and heroin, is a leading cause of accidental death in the USA. The opioid overdose epidemic has been escalating consistently for over a decade.2 Every day, an estimated 91 Americans die from opioid-related overdose.3 Opioid overdose appears to have disproportionally affected men, adults aged 25–64 years, and non-Hispanic whites.2

Brasile 1960: Gli anni della svolta per Alberto Moravia

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Simone Casini

2016-06-01

Full Text Available Alberto Moravia arrived in Brazil in the summer of 1960 to preside the Congress of the PEN Club. He had recently finished La noia, his eleventh novel, the one that most directly is connected to his first novel, Gli indifferenti (1929, and it marks a decisive turning point in his artistic, intellectual, and human course. The essay reconstructs the life and work of the 50-year-old writer, in which a 10-year research is summarized and concluded, opening a new phase. Rereading the articles written for Il Corriere della Sera and the review of the Quarto de despejo by Carolina de Jesus, we focused on the origin and acute reflection of Moravia about Brazil in those years (Brasilia, Bahia, Rio, between past and future. The experience of Brazil, for the writer, who in those following years will attempt new paths in the intellectual and literary field, and new goals for his travels, always more oriented, in the company of Dacia Maraini and Pier Paolo Pasolini, toward the Third World.

50 Years of nuclear power plants in Slovakia

International Nuclear Information System (INIS)

Dobak, D.; Moncekova, M.; Pritrsky, R.

2007-01-01

The publication was prepared to celebration of semi-centennial anniversary of nuclear power plants in Slovakia and presents a free sequel of book '40 years of nuclear power plants in Slovakia'. It contains memories of the observers that are valuable and merits spreading theirs ideas. There are photos in the publication that up to now were not disclosed and that have a unique value not due to their age only. At the same time, the publication expresses an admiration, regard and acknowledgement to all who joined their life with nuclear power. This book contains the following headings: (1) Speech, Lubomir Jahnatek (Minister of Economy of the Slovak Republic); (2) Speech, Jozef Valach; (3) Speech, Paolo Ruzzini; (4) Historic aspects of A1 NPP; (5) Historic Aspects of V1 NPP; (6) Historic Aspects of V2 NPP; (7) A remembrance to Mochovce; (8) Historic Aspects of VYZ; (9) Nuclear power as an integral part of the Slovak power engineering; (10) Under control of supervision; (12) The state health regulation performance in nuclear installations; (13) JAVYS in the Slovak energy sector

The LHC's suppliers come up trumps

CERN Multimedia

2006-01-01

Four of the LHC Project's most exceptional suppliers have just been honoured in the fifth Golden Hadron awards ceremony. For the first time, a CERN team was among the prize-winners. The CERN main workshop (Mechanical and Materials Engineering group, TS/MME) received the Golden Hadron Award at the prize-giving ceremony held at the Globe. From left to right, Saïd Atieh (TS/MME), Vincent Vuillemin (TS/MME group leader), Michel Caccioppoli (TS/MME), Lyn Evans (LHC Project Leader), Marc Polini (TS/MME-MS section leader), Jean-Luc Gayraud (Cegelec), Jean-Paul Bacher (TS/MME-AS section leader) and Paolo Ciriani (head of the TS Department). Flexible, responsive, committed... all fitting adjectives to describe the recipients of the fifth Golden Hadron awards. The prizes, designed to honour the LHC Project's best suppliers, were awarded to a total of four suppliers, including two that are involved in the final accelerator assembly work: proof, if it were needed, that the project has now entered its final phase. Drak...

["Fabulous things". Drug narratives about coca and cocaine in the 19th century].

Science.gov (United States)

Wahrig, Bettina

2009-12-01

This contribution focuses on the history of Coca leaves and Cocaine in the second half of 19th century Europe. Even though, to date, no direct link has been established between the activities of the Milano physician Paolo Mantegazza, and the Göttingen chemist Friedrich Wöhler, it is not a mere coincidence that both published their findings in the same year, namely, 1859. Mantegazza authored the first treatise claiming that Coca had psychoactive qualities and touted its broad therapeutic faculties; he claimed that it should be introduced into European pharmacotherapy. In Wöhler's laboratory, cocaine was isolated from leaves by his pupil Alfred Niemann; later, Wilhelm Lossen refined and corrected Niemann's results. Narratives about medicinal drugs often streamline history into a story that starts with multiple meanings and impure matters and ends with well-defined substances, directed at clear-cut diseases and symptoms. In the case of Coca, however, the pure substance triggered no such process well into the 1880s, whereas the leaves continued to circulate as an exotic, pluripotent drug whose effects where miraculous and yet difficult to establish.

A tool for assessing the quality of nursing handovers: a validation study.

Science.gov (United States)

Ferrara, Paolo; Terzoni, Stefano; Davì, Salvatore; Bisesti, Alberto; Destrebecq, Anne

2017-08-10

Handover, in particular between two shifts, is a crucial aspect of nursing for patient safety, aimed at ensuring continuity of care. During this process, several factors can affect quality of care and cause errors. This study aimed to assess quality of handovers, by validating the Handoff CEX-Italian scale. The scale was translated from English into Italian and the content validity index was calculated and internal consistency assessed. The scale was used in several units of the San Paolo Teaching Hospital in Milan, Italy. A total of 48 reports were assessed (192 evaluations). The median score was 6, interquartile range (IQR) [5;7] and was not influenced by specific (p=0.21) or overall working experience (p=0.13). The domains showing the lowest median values (median=6, IQR [4;8]) were context, communication, and organisation. Night to morning handovers obtained the lowest scores. CVI-S was 0.96, Cronbach's alpha was 0.79. The Handoff CEX-Italian scale is valid and reliable and it can be used to assess the quality of nurse handovers.

Early Solar System Alkali Fractionation Events Recorded by K-Ca Isotopes in the Yamato-74442 LL-Chondritic Breccia

Science.gov (United States)

Tatsunori, T.; Misawa, K.; Okano, O.; Shih, C.-Y.; Nyquist, L. E.; Simon, J. I.; Tappa, M. J.; Yoneda, S.

2015-01-01

Radiogenic ingrowth of Ca-40 due to decay of K-40 occurred early in the solar system history causing the Ca-40 abundance to vary within different early-former reservoirs. Marshall and DePaolo ] demonstrated that the K-40/Ca-40 decay system could be a useful radiogenic tracer for studies of terrestrial rocks. Shih et al. [3,4] determined 40K/40Ca ages of lunar granitic rock fragments and discussed the chemical characteristics of their source materials. Recently, Yokoyama et al. [5] showed the application of the K-40/Ca-40 chronometer for high K/Ca materials in ordinary chondrites (OCs). High-precision calcium isotopic data are needed to constrain mixing processes among early solar system materials and the time of planetesimal formation. To better constrain the solar system calcium isotopic compositions among astromaterials, we have determined the calcium isotopic compositions of OCs and an angrite. We further estimated a source K/Ca ratio for alkali-rich fragments in a chondritic breccia using the estimated solar system initial Ca-40/Ca-44.

The sources of 14th century Italian texts of Abacus: the echoes of an ongoing debate

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Eva Caianiello

2013-12-01

Full Text Available The most common opinion among historians of mathematics is that Fibonacci’s Liber Abaci – or at least the first eleven chapters – was the precursor of the Italian textual tradition of the Abacus and, with respect to the origin of Abacus algebra in Italian, the Libro di ragioni from Paolo Gerardi (1328 was the oldest text on algebra so far known. These ideas have been challenged by many works of J. Høyrup. He maintains that Fibonacci was not a precursor, but only an important exponent of pre-existing Abacus tradition and that the first algebra text in Italian was the Tractatus Algorismi by Jacopo da Firenze. In particular, he articulated all his positions in his book, Jacopo da Firenze’s Tractatus Algorismi Abbacus and Early Italian Culture, which has been the subject of a debate. The author of this article tries to summarize the central theses of Høyrup and explain the different positions taken by the participants in the debate. She will also explain her position in a few cases and her final point of view.

CERN technology in the service of medicine

CERN Multimedia

2001-01-01

The prototype of the first module of the LInac BOster (LIBO) has been constructed and tested at CERN. This new medical accelerator offers new perspectives in deep-seated tumour treatment.   Accelerator technology developed at CERN is set to bring about important advances in cancer therapy. The linac booster - LIBO - project aims to build a 3GHz proton linear accelerator to boost to 200 MeV the energy of the beam from 50-70 MeV cyclotrons, existing in several hospitals and laboratories. This will allow deep-seated tumours to be treated (see box). The prototype of the first LIBO module has just passed high power RF tests at CERN. Two members of the LIBO collaboration, Riccardo Zennaro and Paolo Berra, with the first LIBO module installed in the LIL tunnel. The LIBO idea goes back to 1993 when it was conceived by CERN's Ugo Amaldi, founder of Italy's TERA foundation. From the beginning, Mario Weiss, a former CERN staff member has led the project. A decisive step was taken in 1998 when a collaboration...

The Project Serapis: High Resolution Seismic Imagingof The Campi Flegrei Caldera Structure

Science.gov (United States)

Zollo, A.; Virieux, J.; Capuano, P.; Chiarabba, C.; de Franco, R.; Makris, J.; Michelini, A.; Musacchio, G.; Serapis Group

expected NE-SW and SE-NW structural trends and it has been designed to get 2D/3D images of the crustal structure at a regional scale. A denser 2D network of 35 OBSs has been deployed in the bay of Pozzuoli aimed at detecting and modeling reflected/converted waves from 1 the possible shallow to deep discontinuities beneath the Campi Flegrei caldera. The main target of this particular receiver lay-out is the detailed imaging of the magma chamber top, expected at 4-5 km depth, according to temperature measurements in wells and sparse seismic observations. About 5000 shots have been performed dur- ing the SERAPIS experiment, at an average spatial spacing of 125 m, for a total ship travel path of 620 km. All of the seismic lines have been re-sampled at least twice, using a staggered configuration, which results in a smaller source spacing (less than 65m). In the gulf of Pozzuoli the source array had a geometry of a 5x5 km grid, slightly shifted south with respect to the OBS array. Seismic signals produced by air- guns have been well detected up to 50-60 km distance and the whole Campi Flegrei, Ischia and Procida on-land networks have recorded high quality seismograms pro- duced by the gridded source array in the bay of Pozzuoli. Due to the extended and very dense source and receiver arrays used for SERAPIS, this campaign can provide an innovative contribution to the accurate reconstruction of the Campi Flegrei caldera structure and to the definition of its feeding system at depth. *SERAPIS group: Auger Emmanuel, Bernard Marie-Lise, Bobbio Antonella, Bonagura Mariateresa, Cantore Luciana, Convertito Vincenzo, D'Auria Luca, De Matteis Raffaella, Emolo Anto- nio, Festa Gaetano, Gasparini Paolo, Giberti Grazia, Herrero Andre, Improta Luigi, Lancieri Maria Flora, Nielsen Stefan, Nisii Vincenzo, Russo Guido, Satriano Clau- dio, Simini Mariella, Vassallo Maurizio, Bruno Pier Paolo, Buonocunto Ciro, Capello Marco, Del Pezzo Edoardo, Galluzzo Danilo, Gaudiosi Germana, Giuliana Alessio

Humiliation and love. Villaggio, Benigni and the cultural politics of emotions

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Francesco Ricatti

2014-12-01

Full Text Available Umiliazione e amore: Villaggio, Benigni e la politica culturale delle emozioniLa forte dicotomia emotiva fra eroismo e codardia ha svolto un ruolo importante nella costruzione ed evoluzione dell’identità nazionale italiana. Questo articolo considera le opere più influenti di Paolo Villaggio e Roberto Benigni, e il loro ruolo nello sviluppo di una alternativa emotiva a tale dicotomia. I loro film si concentrano principalmente su una singola emozione: l’umiliazione nel caso di Villaggio, e l’amore nel caso di Benigni. È attraverso questa attenzione ad una singola emozione che questi autori e interpreti sono riusciti a costruire dei personaggi che, pur tipicamente italiani, non possono essere facilmente ricondotti né alla categoria dell’eroe né a quella del codardo. L’articolo sostiene l’importanza politica di questa alternativa emotiva, e nota come il suo progressivo indebolimento sia coinciso con l’incapacità della sinistra italiana di elaborare una risposta efficace alle politiche fortemente emotive di Berlusconi. L’articolo dimostra l’importanza di studiare i complessi rapporti fra comicità, emozioni e politica nella storia culturale e politica italiana.

Psychiatric comorbidity and suicide risk in patients with chronic migraine

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Maurizio Pompili

2010-04-01

Full Text Available Maurizio Pompili1,2, Gianluca Serafini1, Daniela Di Cosimo1, Giovanni Dominici1, Marco Innamorati1, David Lester3, Alberto Forte1, Nicoletta Girardi1, Sergio De Filippis4, Roberto Tatarelli1, Paolo Martelletti41Department of Neurosciences, Mental Health and Sensory Functions, Suicide Prevention Center, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy; 2McLean Hospital, Harvard Medical School, Boston,  Massachusetts, USA; 3The Richard Stockton College of New Jersey, USA; 4Department of Medical Sciences, Second School of Medicine, Sant’Andrea Hospital, Sapienza University of Rome, Rome, ItalyAbstract: The aim of this study was to explore the impact of mental illness among patients with migraine. We performed MedLine and PsycINFO searches from 1980 to 2008. Research has systematically documented a strong bidirectional association between migraine and psychiatric disorders. The relationship between migraine and psychopathology has often been clinically discussed rather than systematically studied. Future research should include sound methodologically-based studies focusing on the interplay of factors behind the relationship between migraine, suicide risk, and mental illness.Keywords: headache, migraine, suicide*, psychiatric disorders

Treatment of obese patients with binge eating disorder using topiramate: a review

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Paolo Leombruni

2009-07-01

Full Text Available Paolo Leombruni, Luca Lavagnino, Secondo FassinoDepartment of Neurosciences, Psychiatry Section, University of Torino, Centre for Eating Disorders and Obesity, Torino, ItalyAbstract: Topiramate is an anticonvulsant drug used for the treatment of epilepsy and prophylaxis of migraine. Some authors have proposed its use as a mood stabilizer and have reported its efficacy in reducing impulsiveness and improving mood regulation, possibly via its antagonism to glutamatergic transmission in the lateral hypothalamus, although this indication is still controversial. Weight loss is a side effect consistently reported in the medical literature in patients treated with topiramate. Given its potential role in stabilizing mood and reducing impulse control problems and weight, topiramate has been proposed as a treatment for obese patients with binge eating disorder (BED. The aim of this paper is to review published data on the efficacy and safety of topiramate for the treatment of obese subjects with BED. Although the evidence is preliminary, topiramate appears to be a relatively safe and effective treatment for obese subjects with BED. Limitations of the studies and future directions for research are discussed.Keywords: topiramate, binge eating disorder, obesity

Dealing with incidents of serious disciplinary problems amongst learners: A comparative study between South Africa and selected countries

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Charl C. Wolhuter

2013-11-01

Full Text Available Teachers in South African schools battle with problems in learner discipline. Research indicates that teachers are at a loss as to handling these situations. The aim of this article is to survey incidents of serious learner misconduct in a representative selection of education systems abroad to extract any guidelines that might be applicable to South African schools. Eight education systems were surveyed: Brazil, England, Turkey, Singapore, Malaysia, China, Australia and New Zealand. The international systems surveyed in this article developed promising models, namely the National Safe Schools Framework (NSSF in Australia, the Response Early Intervention and Assessment Community Health (REACH programme in Singapore, the National Education Plan in the state of São Paolo, Brazil, and the two models in the category of positive disciplinary approaches in New Zealand, namely the Respectful Schools: Restorative Practices in Education and the New Zealand Minister of Education’s Positive Behaviour for [a] Learning Action Plan. A study of these international practices and underlying principles for dealing with discipline in pedagogical situations (Christian or secular could provide guidelines for South African teachers and education authorities.

Discussion on ``Foundations of the Second Law''

Science.gov (United States)

Silbey, Robert; Ao, Ping; Beretta, Gian Paolo; Cengel, Yunus; Foley, Andrew; Freedman, Steven; Graeff, Roderich; Keck, James C.; Lloyd, Seth; Maroney, Owen; Nieuwenhuizen, Theodorus M.; Weissman, Michael

2008-08-01

This article reports an open discussion that took place during the Keenan Symposium "Meeting the Entropy Challenge" (held in Cambridge, Massachusetts, on October 4, 2007) following the short presentations—each reported as a separate article in the present volume—by Seth Lloyd, Owen Maroney, Silviu Guiasu, Ping Ao, Jochen Gemmer, Bernard Guy, Gian Paolo Beretta, Speranta Gheorghiu-Svirschevski, and Dorion Sagan. All panelists and the audience were asked to address the following questions • Why is the second law true? Is it an inviolable law of nature? If not, is it possible to develop a perpetual motion machine of the second kind? • Are second law limitations objective or subjective, real or apparent, due to the nature of physical states or the representation and manipulation of information? Is entropy a physical property in the same sense as energy is universally understood to be an intrinsic property of matter? • Does the second law conflict with quantum mechanics? Are the differences between mechanical and thermodynamic descriptions of physical phenomena reconcilable? Does the reversible law of motion of hamiltonian mechanics and quantum mechanics conflict with the empirical observation of irreversible phenomena?

Atti del seminario internazionale "Immagini d'Italia e d'Europa nella letteratura e nella documentazione di viaggio nel XVIII e nel XIX secolo", (Firenze, 1999-2001

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Renato Pasta

2003-01-01

Full Text Available Renato Pasta, Introduzione. Paolo Marchetti, I giuristi e i confini. L'elaborazione giuridica della nozione di confine tra Medioevo ed età moderna. Jürgen Osterhammel, Atlantic Slavery: A Problem of Cross-Boundary History. Hans Erich Boedeker, "Europe" in the Discourse of the Sciences of State in 18th Century Germany. Sergueï Karp, Les recherches récentes (1990-2000 des relations culturelles franco-russes au XVIIIe siècle. Ananij Gerasimovič Ivanov, Il sistema amministrativo russo nella regione dei Mari dalla seconda metà del XVI al XVIII secolo. Il voevoda. Giulia Cecere, L' «Oriente d'Europa»: un'idea in movimento (sec. XVIII. Un contributo cartografico. Natividad Planas, Conflits de compétence aux frontières. Le contrôle de la circulation des hommes et des marchandises dans le royaume de Majorque au XVIIe siècle. Augustin Hernando, Identidad y representación de Europa en la docencia e investigación geográfica española. Teresa Isenburg, Separare ed Unire. Appunti sulle frontiere brasiliane fra Otto e Novecento: il caso della Guiana britannica

Dress as Civic Celebration in Late Sixteenth-Century Venice: The Woodcuts of Cesare Vecellio’s Habiti antichi et moderni and the Paintings of Paolo Veronese

OpenAIRE

Jones, Ann; Rosenthal, Margaret

2014-01-01

In this essay, we discuss words and images in sixteenth-century Venice in two forms: the prose commentary and woodcuts in Cesare Vecellio's Degli habiti antichi et moderni di diverse parti del mondo (Venice, 1590), and the paintings of Paulo Veronese from 1550 to 1578. Our theoretical framework is the analysis of ideology as it is materialized in the making, wearing and representation of clothing. We study three kinds of dress in Venice: the red silks worn by wealthy merchants, the black wool...

Successes emerge in search for cleaner processes

International Nuclear Information System (INIS)

Anon.

1992-01-01

Faced with mounting public and regulatory pressures, many chemical producers have long adopted pollution reduction efforts. But increasingly, firms are eyeing fundamental process changes to achieve cleaner technologies. In addition to environmental benefits, the promised economic payoffs are clear: higher yields and an escape from soaring waste treatment and disposal costs. Having such technologies, says Paolo Galli, Montecatini's (Milan) director/corporate research, is a tremendous tool. It's becoming an increasingly important competitive element. Indeed, suggests David Hyde, ICI's (London) manager/environmental technology, everyone is looking to use cleaner technologies for a competitive advantage. A number of leading technology groups, including UOP (Des Plaines, IL), are working on replacing hydrofluoric acid (HF) with solid catalysts in alkylation processes. Although it is technologically tough to replace HF or alternative sulfuric acid technology, the rewards could be huge in producing high-octane fuel additives. Catalytica (Mountain View, CA), for one, is building a pilot plant with partners Neste (Helsinki) and Du Pont's Conoco. The company has developed a process to manufacture high-purity DMC by direct synthesis from carbom monoxide, methanol, and oxygen. The medium-pressure process uses a copper salts catalyst system; EniChem says the only significant by-product is carbon dioxide, and there are no chlorinated impurities

PhD Dissertations

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Redazione Reti Medievali (a cura di

2004-06-01

Full Text Available Report of PhD Dissertations. Francesco Barone Istituzioni, società ed economia a Catania nel tardo medioevo (XIV-XV secolo, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004   Laura Berti Ceroni Il territorio e le strutture di Cesarea e Classe tra tarda antichità e alto medioevo in rapporto con Ravenna, Tesi di dottorato di ricerca in Storia e Informatica, Università degli studi di Bologna, 2002-2003.   Marco Bicchierai Poppi dalla signoria dei conti Guidi al vicariato del Casentino (1360-1480, Tesi di dottorato in Storia medievale (XIV ciclo, Università degli Studi di Firenze, 2004   Emanuela Garimberti Spatiosa ad habitandum loca. Luoghi e identità nella Historia Langobardorum di Paolo Diacono, Tesi di dottorato in Storia medievale (XV ciclo, Università degli Studi di Bologna, 2004   Lorenzo Tanzini Sistemi normativi e pratiche istituzionali a Firenze dalla fine del XIII all’inizio del XV secolo, Tesi di dottorato di ricerca in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004   Stefania Tarquini Pellegrinaggio e asseto urbano di Roma, Tesi di dottorato di ricerca in Storia dei centri, delle vie e della cultura dei pellegrinaggi nel Medioevo euro mediterraneo (XV ciclo, Università degli studi di Lecce, 2003

Nonmotor symptoms in Parkinson's disease: classification and management

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Erro R

2015-01-01

Full Text Available Roberto Erro,1,2 Gabriella Santangelo,3,4 Paolo Barone,5 Carmine Vitale4,6 1Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom; 2Dipartimento di Scienze Neurologiche e del Movimento, Università di Verona, Verona, Italy; 3Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy; 4IDC Hermitage – Capodimonte, Naples, Italy; 5University of Salerno, Center for Neurodegenerative diseases – CEMAND, Salerno, Italy; 6University of Naples "Parthenope," Department of Motor Sciences, Naples, Italy Abstract: Despite the emphasis on the motor phenotype of Parkinson's disease (PD, it has been increasingly recognized that PD patients experience several nonmotor symptoms (NMS, which have even greater significance when assessed by quality-of-life measures and institutionalization rates. The burden of NMS tends to increase with age and disease severity and, in the very advanced stage of disease, NMS such as urinary problems, drooling, somnolence, psychosis, and dementia dominate the clinical phenotype. Moreover, the dopaminergic treatment used for the motor symptoms of PD can arise or worsen a number of NMS, including orthostatic hypotension, nausea, sleep disturbances, hallucinations, or impulsive compulsive behaviors. Here we review the most common NMS of PD with a focus on their pharmacological management. Keywords: disease management, PD, NMS

Prediction of site-specific interactions in antibody-antigen complexes: the proABC method and server.

KAUST Repository

Olimpieri, Pier Paolo

2013-06-26

MOTIVATION: Antibodies or immunoglobulins are proteins of paramount importance in the immune system. They are extremely relevant as diagnostic, biotechnological and therapeutic tools. Their modular structure makes it easy to re-engineer them for specific purposes. Short of undergoing a trial and error process, these experiments, as well as others, need to rely on an understanding of the specific determinants of the antibody binding mode. RESULTS: In this article, we present a method to identify, on the basis of the antibody sequence alone, which residues of an antibody directly interact with its cognate antigen. The method, based on the random forest automatic learning techniques, reaches a recall and specificity as high as 80% and is implemented as a free and easy-to-use server, named prediction of Antibody Contacts. We believe that it can be of great help in re-design experiments as well as a guide for molecular docking experiments. The results that we obtained also allowed us to dissect which features of the antibody sequence contribute most to the involvement of specific residues in binding to the antigen. AVAILABILITY: http://www.biocomputing.it/proABC. CONTACT: anna.tramontano@uniroma1.it or paolo.marcatili@gmail.com SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Characterization of an abandoned pastoral area in the Northern Apennines, Italy

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Argenti G

2006-01-01

Full Text Available This paper reports the first results of an investigation carried out within the research project "Study and improvement of woods and shrubbery derived from abandoned agricultural areas" (RiSelvItalia Project. Changes occurred in the past 50 years in the pastoral area of S. Paolo in Alpe (Appennino Romagnolo, Northern Apennines, Italy were described on the grounds of photo-interpretation of three sets of aerial photos (1955, 1976, 1997. A high reduction of the surface of sowable lands and pastures (from 80% to 33% was pointed out, together with an increase of shrubbery (from 5% to 18% and woods (from 0 to 42%. The characterization of woods, shrubbery and pastures was performed through structural transects and phyto-sociological investigations. Thus it was possible to reconstruct the dynamic series of vegetation, from grasslands belonging to the association Centaureo bracteatae-Brometum erecti (Festuco-Brometea to woods referable to the association Aceri obtusati-quercetum cerridis (Querco-Fagetea. Investigations on meadows revealed also a good quality of pastures, not only in open grasslands (mean pastoral value - VP - of 30, but even in partially shrubby areas (VP 21. Some guidelines for a multi-purpose exploitation of the site are suggested, taking into account not only economic aspects, but also the conservation of environment and landscape.

A unified approach to model uptake kinetics of trace elements in complex aqueous – solid solution systems

International Nuclear Information System (INIS)

Thien, Bruno M.J.; Kulik, Dmitrii A.; Curti, Enzo

2014-01-01

Highlights: • There are several models able to describe trace element partitioning in growing minerals. • To describe complex systems, those models must be embedded in a geochemical code. • We merged two models into a unified one suitable for implementation in a geochemical code. • This unified model was tested against coprecipitation experimental data. • We explored how our model reacts to solution depletion effects. - Abstract: Thermodynamics alone is usually not sufficient to predict growth-rate dependencies of trace element partitioning into host mineral solid solutions. In this contribution, two uptake kinetic models were analyzed that are promising in terms of mechanistic understanding and potential for implementation in geochemical modelling codes. The growth Surface Entrapment Model (Watson, 2004) and the Surface Reaction Kinetic Model (DePaolo, 2011) were shown to be complementary, and under certain assumptions merged into a single analytical expression. This Unified Uptake Kinetics Model was implemented in GEMS3K and GEM-Selektor codes ( (http://gems.web.psi.ch)), a Gibbs energy minimization package for geochemical modelling. This implementation extends the applicability of the unified uptake kinetics model to accounting for non-trivial factors influencing the trace element partitioning into solid solutions, such as the changes in aqueous solution composition and speciation, or the depletion effects in closed geochemical systems

Sport, biopolitics and critique of political economy

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Milorad Gačević

2012-07-01

Full Text Available In this text we tried to point out the relationship between labour and biopolitical mechanisms of power in the context of the current situation in elite sport. In the first part we present developments inside left-oriented theories of sport, especially the need for critical research based on specific aspects of criticism of political economy. We then review brief the current situation in contemporary sport, mainly about parallel evolution of the capitalist commodification of sport and the emergence of the application of biopolitically directed practices, where we have tried to implement a short overview of Foucault’s concepts in the field of sport studies. The third part deals with the connection between Paolo Virno’s biopolitical studies and Marx’s labour power. In conclusion, we raise the possibility of applying Virno’s settings to treat sport practice in the context of its appropriation by capitalism, characterised by the intensification of strategies and techniques for controlling sportsman life. According to Virno’s settings we have tried to show influence to a life of sportsman in the aim of bio-potency, the ability/power to produce a labour force, while this force is treated like labour exchanged in the market in the context of capitalist commodification of modern sport.

Tracing the fate of sulfamethoxazole and its metabolites in subsurface: conceptualization and modelling

Science.gov (United States)

Rodriguez-Escales, Paula; Sanchez-Vila, Xavier

2016-04-01

The degradation of low adsorptive SMX in subsurface porous media is spatially and temporally variable. It depends on various environmental factors such as in situ redox potential, availability of nutrients, local soil characteristics, and temperature. Its degradation is better under anoxic conditions and by co-metabolism processes. In this work, we first develop a conceptual model of degradation of SMX under different redox conditions (denitrification and iron reducing conditions), characterizing the metabolite formation in each condition, and second, we construct a mathematical model that allows reproducing different experiments of SMX degradation reported in the literature. The model was validated using the experimental data from Barbieri et al. (2012), Nödler et al. (2012) and Mohatt et al. (2011). The model reproduces the reversible degradation of SMX under the presence of nitrous acid as an intermediate product of denitrification (it is the conjugate acid of nitrite), as well as, the metabolite formation (4-nitro-SMX and desamino SMX). In those experiments degradation was mediated by the transient formation of a diazonium cation, which was considered responsible of the substitution of the amine radical by a nitro radical, forming the 4-nitro-SMX. On the other hand, both the diazonium compound and the methanol present in the experiment produced a deamination in the SMX, producing desamino-SMX. The formation of these metabolites was unstable and they were retransformed to SMX. Concerning the iron conditions, SMX was degraded due to the oxidation of iron (Fe2+), which was previously oxidized from goethite due to the degradation of a pool of labile organic carbon. As the oxidation of iron occurred on the goethite surface, the best model to reproduce the SMX reduction was a power law rate. Our work is an attempt to properly formulate the degradation process of an emerging compound considering the real degradation mechanisms, rather than using an upscaled black

5th National Congress of the Italian Society of Physiotherapy

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Alessandro Aina

2016-10-01

Full Text Available Table of contents S1 Criteria for exercises selection in subjects with low back pain Alessandro Aina S2 Recent advances in pathophysiology and treatment of myofascial trigger points Marco Barbero S3 Rehabilitation of scapular dyskinesia Barbara Cagnie S4 Musculoskeletal rehabilitation in subjects affected by neurological disorders Elena Castelli S5 Which examination tests suggest the best candidates for manual therapy Chad Cook S6 Case study: the role of the measurements for the identification of targets and guidance of the treatment Silvano Ferrari S7 Assessment of joint mobility: state of the art Andrea Foglia, Paolo Bizzarri S8 Core stabilization exercises in the treatment of urinary incontinence Donatella Giraudo S9 Preventing surgical subacromial decompression through rotator cuff rehabilitation Chris Littlewood S10 Methodological aspects of Clinical Prediction Rules in the rehabilitation of Low Back Pain Paolo Pillastrini S11 Interpretability of outcome measures in musculoskeletal rehabilitation Daniele Piscitelli S12 Conservative treatment of the misalignment of the spine: state of the art and perspectives Michele Romano S13 Balance training in subjects with musculoskeletal disorders Andrea Tettamanti S14 Dosage of manual therapy: principles for clinical practice Carla Vanti S15 Are there speed limits in post-surgery lower limb rehabilitation? Stefano Vercelli S16 Classification of predominant neuropathic, nociceptive or central sensation pain Lennard Voogt P1 A wearable proprioceptive stabilizer (Equistasi® for rehabilitation of balance disorders in multiple sclerosis patients: preliminary results of a randomized, double-blind, versus placebo controlled study Aceto Maria, Spina Emanuele, Paone Paolo, Silvestre Francesco, Carotenuto Antonio, Cerillo Ilaria, Orefice Giuseppe P2 Effect of repeated neck retraction movements on strength and EMG activity of the upper limbs, range of motion and cervical posture Bassi Raffaele, Fiorito Serena

Reconsidering Written Language

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Gopal P. Sarma

2015-07-01

Full Text Available A number of elite thinkers in Europe during the 16th and 17th centuries pursued an agenda which historian Paolo Rossi calls the “quest for a universal language,” a quest which was deeply interwoven with the emergence of the scientific method. From a modern perspective, one of the many surprising aspects of these efforts is that they relied on a diverse array of memorization techniques as foundational elements. In the case of Leibniz’s universal calculus, the ultimate vision was to create a pictorial language that could be learned by anyone in a matter of weeks and which would contain within it a symbolic representation of all domains of contemporary thought, ranging from the natural sciences, to theology, to law. In this brief article, I explore why this agenda might have been appealing to thinkers of this era by examining ancient and modern memory feats. As a thought experiment, I suggest that a society built entirely upon memorization might be less limited than we might otherwise imagine, and furthermore, that cultural norms discouraging the use of written language might have had implications for the development of scientific methodology. Viewed in this light, the efforts of Leibniz and others seem significantly less surprising. I close with some general observations about cross-cultural origins of scientific thought.

Narrativity and enaction: the social nature of literary narrative understanding.

Science.gov (United States)

Popova, Yanna B

2014-01-01

This paper proposes an understanding of literary narrative as a form of social cognition and situates the study of such narratives in relation to the new comprehensive approach to human cognition, enaction. The particular form of enactive cognition that narrative understanding is proposed to depend on is that of participatory sense-making, as developed in the work of Di Paolo and De Jaegher. Currently there is no consensus as to what makes a good literary narrative, how it is understood, and why it plays such an irreplaceable role in human experience. The proposal thus identifies a gap in the existing research on narrative by describing narrative as a form of intersubjective process of sense-making between two agents, a teller and a reader. It argues that making sense of narrative literature is an interactional process of co-constructing a story-world with a narrator. Such an understanding of narrative makes a decisive break with both text-centered approaches that have dominated both structuralist and early cognitivist study of narrative, as well as pragmatic communicative ones that view narrative as a form of linguistic implicature. The interactive experience that narrative affords and necessitates at the same time, I argue, serves to highlight the active yet cooperative and communal nature of human sociality, expressed in the many forms than human beings interact in, including literary ones.

GPU-powered model analysis with PySB/cupSODA.

Science.gov (United States)

Harris, Leonard A; Nobile, Marco S; Pino, James C; Lubbock, Alexander L R; Besozzi, Daniela; Mauri, Giancarlo; Cazzaniga, Paolo; Lopez, Carlos F

2017-11-01

A major barrier to the practical utilization of large, complex models of biochemical systems is the lack of open-source computational tools to evaluate model behaviors over high-dimensional parameter spaces. This is due to the high computational expense of performing thousands to millions of model simulations required for statistical analysis. To address this need, we have implemented a user-friendly interface between cupSODA, a GPU-powered kinetic simulator, and PySB, a Python-based modeling and simulation framework. For three example models of varying size, we show that for large numbers of simulations PySB/cupSODA achieves order-of-magnitude speedups relative to a CPU-based ordinary differential equation integrator. The PySB/cupSODA interface has been integrated into the PySB modeling framework (version 1.4.0), which can be installed from the Python Package Index (PyPI) using a Python package manager such as pip. cupSODA source code and precompiled binaries (Linux, Mac OS/X, Windows) are available at github.com/aresio/cupSODA (requires an Nvidia GPU; developer.nvidia.com/cuda-gpus). Additional information about PySB is available at pysb.org. paolo.cazzaniga@unibg.it or c.lopez@vanderbilt.edu. Supplementary data are available at Bioinformatics online. © The Author(s) 2017. Published by Oxford University Press.

Terracina - terra di briganti, tappa prediletta dai (grand- turisti

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Clemens Arts

2012-05-01

Full Text Available Terracina: bandit territory and resort cherished by (grand- touristsFor travellers who left the Eternal City, Terracina was one of the first stages, and almost an obligatory one, on their way to Naples and further south. The charming fishing town on the Tyrrhenian Sea situated on the Via Appia offered to those who had crossed the boring and bothersome Pontine Marshes a glimpse of the lushest Mediterranean vegetation and views. Yet another aspect of Terracina’s historical background is the protracted terrifying presence of notorious bandits such as Fra Diavolo and Gasbarrone.This article questions the imagological implications of these mytho-cultural assets of Terracina in literature, with a focus on ‘Romantic’ early Nineteen Century travel literature at large (Irving Washington, Stendhal, in which the point of view is mostly from a visitor's perspective, whereas authoritative studies, e.g. by Eric Hobsbawm, have rightly stressed the crucial importance of the insiders’ point of view as well.As an excursus from this cultural and historical context Pier Paolo Pasolini’s delicious ‘Terracina’ comes in to offer just such an insider’s point of view, telling the story of two Roman ‘ragazzi di vita’ – or ‘briganti’, as the villagers call them – who become tourists themselves and get fatally attracted by the idyllic Terracina seascape.

Narrativity and Enaction: The Social Nature of Literary Narrative Understanding

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Yanna B. Popova

2014-08-01

Full Text Available This paper proposes an understanding of literary narrative as a form of social cognition and situates the study of such narratives in relation to the new comprehensive approach to human cognition, enaction. The particular form of enactive cognition that narrative understanding is proposed to depend on is that of participatory sense-making, as developed in the work of Di Paolo and De Jaegher. Currently there is no consensus as to what makes a good literary narrative, how it is understood, and why it plays such an irreplaceable role in human experience. The proposal thus identifies a gap in the existing research on narrative by describing narrative as a form of intersubjective process of sense-making between two agents, a teller and a reader. It argues that making sense of narrative literature is an interactional process of co-constructing a story-world with a narrator. Such an understanding of narrative makes a decisive break with both text-centered approaches that have dominated both structuralist and early cognitivist study of narrative, as well as pragmatic communicative ones that view narrative as a form of linguistic implicature. The interactive experience that narrative affords and necessitates at the same time, I argue, serves to highlight the active yet cooperative and communal nature of human sociality, expressed in the many forms than human beings interact in, including literary ones.

Calcium Isotopic Composition of Bulk Silicate Earth

Science.gov (United States)

Kang, J.; Ionov, D. A.; Liu, F.; Zhang, C.; Zhang, Z.; Huang, F.

2016-12-01

Ca isotopes are used to study the accretion history of the Earth and terrestrial planets, but, Ca isotopic composition of the Bulk Silicate Earth (BSE) remains poorly constrained [1]. To better understand the Ca isotopic composition of BSE, we analyzed 22 well studied peridotite xenoliths from Tariat (Mongolia), Vitim (southern Siberia) and Udachnaya (Siberian Craton). These samples include both fertile and highly depleted garnet and spinel peridotites that show no or only minor post-melting metasomatism or alteration. Ca isotope measurements were done on a Triton-TIMS using double spike method at the Guangzhou Institute of Geochemistry, CAS. The data are reported as δ44/40Ca (relative to NIST SRM 915a). Results for geostandards are consistent with those from other laboratories. 2 standard deviations of SRM 915a analyses are 0.13‰ (n=48). δ44/40Ca of both and fertile and refractory peridotites range from 0.79 to 1.07‰ producing an average of 0.93±0.12‰ (2SD). This value defines the Ca isotopic composition of the BSE, which is consistent with the average δ44/40Ca of oceanic basalts ( 0.90‰)[2,3]. [1] Huang et al (2010) EPSL 292; [2] Valdes et al (2014) EPSL 394; [3]DePaolo (2004) RMG 55.

Sedimentologie and stratigraphic s aspects of conglomeratic sandstones belong to the channel between of the Pirambora and Botucatu formations (mesozoic basin of Parana)district of Sao Paolo Brazil

International Nuclear Information System (INIS)

Caetano Chang, M.

1998-01-01

The interest of present study is concerned to the sedimentogenic characterization of fluvial conglomeratic sandstones that occur close to the top of Piramboia Formation.These deposits are interpreted as braided channel bar facies, deposited on alluvial fans at the border of desertic environment. The sandstones are fine to coarse, with variable percentage of gravel. These are dominantly quart zones and median scale trough cross-bedded. (author)

Suicide risk in depression and bipolar disorder: Do impulsiveness-aggressiveness and pharmacotherapy predict suicidal intent?

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Maurizio Pompili

2008-03-01

Full Text Available Maurizio Pompili1,2, Marco Innamorati3, Michele Raja4, Ilaria Falcone2, Giuseppe Ducci5, Gloria Angeletti2, David Lester6, Paolo Girardi2, Roberto Tatarelli2, Eleonora De Pisa21McLean Hospital, Harvard Medical School, Boston, MA, USA; 2Department of Psychiatry, Sant’Andrea Hospital, “Sapienza” University of Rome, Italy; 3Università Europea di Roma, Italy; 4Diagnostic and Therapeutic Psychiatric Services, Department of Mental Health, Santo Spirito Hospital, Rome, Italy; 5Diagnostic and Therapeutic Psychiatric Services, Department of Mental Health, San Filippo Neri Hospital, Rome, Italy; 6Center for the Study of Suicide, Blackwood, NJ, USAAbstract: The aims of the present study were to examine clinical, personality, and sociodemographic predictors of suicide risk in a sample of inpatients affected by major affective disorders. The participants were 74 inpatients affected by major depressive disorder or bipolar disorder-I. Patients completed a semi-structured interview, the Beck Hopelessness Scale, the Aggression Questionnaire, the Barratt Impulsiveness Scale, and the Hamilton scales for depression and anxiety. Over 52% of the patients were high suicide risks. Those at risk reported more severe depressive-anxious symptomatology, more impulsivity and more hostility. Impulsivity, the use of antidepressants, anxiety/somatization, and the use of mood stabilizers (a negative predictor resulted in accurate predicting of suicide intent. Impulsivity and antidepressant use were the strongest predictors even after controlling for several sociodemographic and clinical variables.Keywords: suicide, mood disorders, pharmacotherapy, impulsiveness, aggressiveness

The role of asenapine in the treatment of manic or mixed states associated with bipolar I disorder

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Pompili M

2011-05-01

Full Text Available Maurizio Pompili1,2, Paola Venturini1, Marco Innamorati1, Gianluca Serafini1, Ludovica Telesforo1, David Lester3, Roberto Tatarelli1, Paolo Girardi11Department of Neurosciences, Mental Health and Sensory Functions, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy; 2McLean Hospital, Harvard Medical School, Boston, MA, USA; 3The Richard Stockton College of New Jersey, Pomona, NJ, USABackground: Bipolar disorders (BD are of particular public health significance as they are prevalent, severe and disabling, and often associated with elevated risks of premature mortality. The aim of this concise overview is to investigate the role of asenapine in the treatment of manic and mixed states associated with BD type 1 disorder.Method: MedLine, Excerpta Medica and PsycINFO searches were performed to identify papers in English published over the past 7 years. Search terms were "asenapine", "manic" OR "mixed states", "bipolar I disorder". Subjects included in this study suffered from BD type 1 disorder.Results: To date, only four studies of asenapine for the treatment of manic or mixed episodes associated with BD type 1 have been published.Conclusion: Research indicates that asenapine is generally well-tolerated, and that asenapine is efficacious and not inferior to olanzapine in the treatment of mixed or manic episodes associated with BD type 1 in the short-term and long-term.Keywords: asenapine, bipolar disorder, side effects

Is placebo useful in the treatment of major depression in clinical practice?

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Marchesi C

2013-06-01

Full Text Available Carlo Marchesi, Chiara De Panfilis, Matteo Tonna, Paolo Ossola University of Parma, Department of Neuroscience, Psychiatric Unit, Parma, Italy Background: For many years, placebo has been defined by its inert content and use in clinical trials. In recent years, several studies have demonstrated its effect in the treatment of major depression. The aim of this paper is to present the conclusions of recent meta-analyses of the placebo effect in major depression, to explain the mechanism by which placebo exerts its effect, and to discuss whether placebo can be used in the treatment of patients with major depression in clinical practice. Recent meta-analyses have demonstrated that the placebo effect is estimated to account for 67% of the treatment effect in patients receiving antidepressants, and furthermore that placebo is as effective as antidepressants in patients with mild to moderate major depression (reporting a Hamilton Depression Rating Scale score lower than 25, whereas placebo is less effective than antidepressants in severely depressed patients. However, several limitations make the translation of these conclusions into clinical practice impracticable. Clinicians should learn from the "placebo lesson" to maximize the nonspecific effects of treatment when they prescribe an antidepressant, particularly in less severely depressed patients, who show a higher placebo response in randomized controlled trials. This strategy can increase the antidepressant effect and may reduce nonadherence with treatment. Keywords: placebo effect, major depressive disorder, subthreshold depressive disorder, antidepressants

Motor learning in Sport. A short stroll into a (unfamiliar world. [Aprendizaje motor en el deporte: Un corto paseo por un mundo (desconocido].

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Luis Miguel Ruiz

2015-01-01

Full Text Available It was in 1990 when Quest published an issue about “Usefulness of motor learning research for physical educators”. Several scholars tried to give an answer to this question, while motor learning researchers were in favour of this kind of scientific knowledge (Singer, 1990, Magill, 1990 pedagogues were more sceptical (Locke, 1990; Hoffman, 1990. Is it still a question that needs an answer? Does motor learning and expertise research useful for coaches and teachers? To quote J. von Uexkül “perhaps it would be a good idea to give a short stroll into the world of this (unfamiliar world”. Recently the philosophy of mind and philosophy of sport has begun to focus on sport expertise (Breivik, 2007; Moe, 2005. Today we are witnessing a change of the explanatory model of motor skill acquisition. Computational and computer metaphor is rejected and dynamic, sensorimotor, extended and enactive positions are the fashionable approaches (Araujo, 2013; Aviles et al., 2014; Clark and Chalmers, 2011; Davids, 2015; Froese and Di Paolo, 2011; Noë, 2010. In some cases these positions are coincidences but not in others. All of the researchers are agree upon the need to consider the mutuality of human beings and their surroundings. The computer metaphor, which at the time was the paradigm of any explanation, is now beginning to be seen as an overcome idea(Moe, 2005; Varela, Thompson and Rosch, 2005.

Optimising the weighting of the water retention index using sensitivity analysis

Science.gov (United States)

Becker, William; Vandecasteele, Ine

2015-04-01

A robust composite indicator was developed to assess the capacity of the landscape to regulate and retain water passing through it at Pan-European scale. The "Water Retention Index" (WRI) takes into account the role of interception by vegetation, the water-holding capacity of the soil, and the relative capacity of the bedrock to allow percolation of water, as well as the influence of soil sealing and slope gradient. A delicate issue in composite indicators is however the relative weighting of each variable used in the indicator - strong correlations and skewness are known to cause unequal influence of the input variables, even though the weighting coefficients are equal (Paruolo et al, 2013). To understand the effects of the weightings in the WRI, penalised splines were used to calculate the first order sensitivity index of each variable used in the construction of the WRI, allowing the true influence of each input to be determined. Furthermore, the weighting coefficients were optimised using an iterative nonlinear algorithm to find the coefficients which resulted in the most equal influence of each input to the indicator. In principle, this approach can be used to improve the weighting of many different kinds of composite indicator, the results of which are often used as the basis for important policy decisions at the European level. Paruolo, Paolo, Michaela Saisana, and Andrea Saltelli. "Ratings and rankings: voodoo or science?." Journal of the Royal Statistical Society: Series A (Statistics in Society) 176.3 (2013): 609-634.

Il Peccato Originale nella tradizione cristiana e nella letteratura russa

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Stefano M. Capilupi

2011-11-01

Full Text Available Le tre tappe essenziali della storia religiosa dell’uomo nella tradizione cristiana, prese nel loro aspetto dogmatico così come quest’ultimo viene comunemente inteso, risultano le seguenti: creazione del Paradiso Terrestre, Peccato Originale come causa della morte, redenzione attraverso l’incarnazione di Dio (che si considera necessaria per il ritorno del mondo alla sua condizione originaria. In questa veste anselmiana le 'ricette' della concezione ortodossa della salvezza per i personaggi di Dostoevskij non risultano sufficienti. La fede – secondo una delle interpretazioni teologiche più profonde delle parole dell’apostolo Paolo – è in realtà ‘‘skólops tè sarkì”, ‘‘ago” di domande ‘‘nella carne” (2 Cor. 12, 7. Tento in questa sede di chiarire la problematica del Peccato Originale in Dostoevskij alla luce dei rapporti fra teologia, patristica e liturgia d’Oriente (che dovrebbero negare, in teoria, teologumeni prettamente occidentali, come quello dell’ereditarietà della colpa e teologia, patristica e liturgia d’Occidente, in relazione per altro con l’esegesi scientifica dell’Antico e del Nuovo Testamento. Un fondo supplementare d’indagine ci è dato dalle riflessioni dei pensatori russi che hanno vissuto e operato al confine fra i secoli XIX e XX. In conclusione la stessa ortodossia russa nella sua complessità si rivelerà una singolare intersezione fra le tradizioni cristiane d’Oriente e d’Occidente.

Modelling sulfamethoxazole degradation under different redox conditions

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Sanchez-Vila, X.; Rodriguez-Escales, P.

2015-12-01

Sulfamethoxazole (SMX) is a low adsorptive, polar, sulfonamide antibiotic, widely present in aquatic environments. Degradation of SMX in subsurface porous media is spatially and temporally variable, depending on various environmental factors such as in situ redox potential, availability of nutrients, local soil characteristics, and temperature. It has been reported that SMX is better degraded under anoxic conditions and by co-metabolism processes. In this work, we first develop a conceptual model of degradation of SMX under different redox conditions (denitrification and iron reducing conditions), and second, we construct a mathematical model that allows reproducing different experiments of SMX degradation reported in the literature. The conceptual model focuses on the molecular behavior and contemplates the formation of different metabolites. The model was validated using the experimental data from Barbieri et al. (2012) and Mohatt et al. (2011). It adequately reproduces the reversible degradation of SMX under the presence of nitrite as an intermediate product of denitrification. In those experiments degradation was mediated by the transient formation of a diazonium cation, which was considered responsible of the substitution of the amine radical by a nitro radical, forming the 4-nitro-SMX. The formation of this metabolite is a reversible process, so that once the concentration of nitrite was back to zero due to further advancement of denitrification, the concentration of SMX was fully recovered. The forward reaction, formation of 4-nitro SMX, was modeled considering a kinetic of second order, whereas the backward reaction, dissociation of 4-nitro-SMX back to the original compound, could be modeled with a first order degradation reaction. Regarding the iron conditions, SMX was degraded due to the oxidation of iron (Fe2+), which was previously oxidized from goethite due to the degradation of a pool of labile organic carbon. As the oxidation of iron occurred on the

Introducción a la historiografía sobre la «lengua» de Italia de la orden de San Juan de Jerusalén en la Edad Moderna

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Angelantonio SPAGNOLETTI

2009-12-01

Full Text Available RESUMEN: Organizar racionalmente los cientos de títulos dedicados a la Lengua de Italia de la orden de San Juan publicados entre los siglos XVI y XX resulta complicado, siendo más útil una aproximación cronológica. El principal punto de referencia se sitúa en las historias generales clásicas del siglo XVI ampliamente documentadas, con espíritu aristocrático y laudatorio hacia la orden (Giacomo Bosio, 1594-1602, Bartolomeo Dal Pozzo, 1589 continuadas en el XVIII (Giandonato Rogadeo, 1782, que culminan con Paolo Maria Paciauli (1780, autor de una construcción teórica que desde la Edad Media delineaba los rasgos de la civilización de la Europa católica. La idea de que los caballeros de la orden de Malta encarnaban los principios espirituales y aristocráticos exigibles a la nobleza italiana destinada al gobierno de las distintas unidades políticas de la península itálica, queda reflejada en muchos escritos de estos siglos. Por otra parte, la defensa de privilegios y derechos propios, junto a las relaciones de los hechos de armas, especialmente de las naves maltesas, y los ruoli o listados de caballeros y sus dignidades, constituyen una parte importante de las ediciones relativas a la orden. Tras casi haber desaparecido su poder político en el siglo XIX, y manteniéndose una línea historiogràfica centrada en aspectos heráldicos y genealógicos, ha sido preciso esperar hasta fines del siglo XX para que la historiografía académica ponga sus ojos en unos archivos preciosos para el estudio del mundo rural, de las relaciones de poder y otros muchos aspectos descuidados en las historias tradicionales de la orden de Malta.ABSTRACT: The essay of a rational organization of hundreds of titles devoted to Tongue of Italy of the Order of Saint John of Jerusalem is a difficult task, and a chronological approach seems to be more useful. The main reference point is located in classic general histories from the XVIth century (Giacomo Bosio

PhD Dissertations Tesi di dottorato

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Redazione Reti Medievali (a cura di

2004-06-01

Full Text Available

Report of PhD Dissertations.

Francesco Barone

Istituzioni, società ed economia a Catania nel tardo medioevo (XIV-XV secolo, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004

Laura Berti Ceroni

Il territorio e le strutture di Cesarea e Classe tra tarda antichità e alto medioevo in rapporto con Ravenna, Tesi di dottorato di ricerca in Storia e Informatica, Università degli studi di Bologna, 2002-2003.

Marco Bicchierai

Poppi dalla signoria dei conti Guidi al vicariato del Casentino (1360-1480, Tesi di dottorato in Storia medievale (XIV ciclo, Università degli Studi di Firenze, 2004

Emanuela Garimberti

Spatiosa ad habitandum loca. Luoghi e identità nella Historia Langobardorum di Paolo Diacono, Tesi di dottorato in Storia medievale (XV ciclo, Università degli Studi di Bologna, 2004

Lorenzo Tanzini

Sistemi normativi e pratiche istituzionali a Firenze dalla fine del XIII all’inizio del XV secolo, Tesi di dottorato di ricerca in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004

Stefania Tarquini

Pellegrinaggio e asseto urbano di Roma, Tesi di dottorato di ricerca in Storia dei centri, delle vie e della cultura dei pellegrinaggi nel Medioevo euro mediterraneo (XV ciclo, Università degli studi di Lecce, 2003

Segnalazione di tesi di dottorato.

Francesco Barone

Istituzioni, società ed economia a Catania nel tardo medioevo (XIV-XV secolo, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004

Laura Berti Ceroni

List of participants of the VI School on Cosmic Rays and Astrophysics 17-25 November 2015, Chiapas, Mexico

International Nuclear Information System (INIS)

2017-01-01

Lecturers: 1.- Oscar Saavedra San Martín Università di Torino and Istituto Nazionale di FisicaNucleare (INFN, Italy) 2.- Mario Rodríguez Cahuantzi Benemérita Universidad Autónoma de Puebla (BUAP) 3.- Alberto Carramiñana Instituto Nacional de Astrofísica, Óptica y Electrónica (INAOE, Mexico) 4.- Marco Casolino Rikagaku Kenkyusho, Research Institute (RIKEN, Japan) and INFN (Italy) 5.- Paolo Desiati Wisconsin IceCube Particle Astrophysics Center (WIPAC), Department of Astronomy (Madison, USA) 6.- Paolo Lipari Sezione Roma I dell’ INFN, Universita’ degli Studi “La Sapienza” c/o Istituto di Fisica (Italy) 7.- Juan Carlos Arteaga Velázquez Instituto de Física y Matemáticas of Universidad Michoacana de San Nicolás de Hidalgo (IFM-UMSNH, Mexico) 8.- Karen Salomé Caballero Mora Facultad de Ciencias en Física y Matemáticas, Universidad Autónoma de Chiapas (FCFM-UNACH, Mexico) 9.- Pat Harding Los Alamos National Laboratory (LANL, USA) 10.- Omar Miranda Romagnoli Departamento de Física, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-Mexico) 11.- Pierluigi Belli INFN Roma Tor Vergata (Italy) 12.- Giuseppe Di Sciascio Departament of Physics (INFN, Italy) 13.- César Álvarez Ochoa FCFM-UNACH, Mexico 14.- Luis Villaseñor IFM-UMSNH, Mexico 15.- Jorge Romo FCFM-UNACH, Mexico 16.- Lukas Nellen Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México (ICN-UNAM, Mexico) Students: 1.- Ibrahim Torres, INAOE, Mexico 2.-Andrea Correa, Escuela Politécnica Nacional, Ecuador 3.- Humberto Martínez Huerta, CINVESTAV, Mexico 4.- Iván Antonio Cárdenas Muñoz, Universidad de Sonora, Mexico 5.- Juan Antonio Salazar Contreras, Escuela de Ciencias Físicas y Matemáticas, Universidad de San Carlos de Guatemala, USAC, Guatemala 6.- Pravda Linda Flor Cabrera Vogel, USAC, Guatemala 7.- Luis Guillermo García Ordóñez, USAC, Guatemala 8.- Marco Antonio Morales Ovalle, USAC, Guatemala 9.- Joshua Raphael L�

Length of hospitalization is associated with selected biomarkers (albumin and lymphocytes) and with co-morbidities: study on 4000 patients.

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Pontiroli, Antonio E; Loreggian, Lara; Rovati, Marco P L; De Patto, Elena; Folini, Laura; Raveglia, Federico; De Simone, Matilde; Baisi, Alessandro; Cioffi, Ugo

2017-01-01

Low albumin levels and low lymphocyte counts are intra hospital conditions that exert a negative influence on prognosis, healing and length of hospitalization. The study aimed to analyze the correlation between low blood levels of albumin, low lymphocytes, and length of stay. The secondary aim was to identify other co-morbidities associated with prolonged hospital stay. Retrospective pilot study was conducted by analyzing anamnestic and biochemical data, related to 4038 patients admitted to ten wards of Hospital San Paolo (Milan), collected from July 1 st 2012 to December 31 st 2012. A statistical analysis was carried out using the Correlation method, Multivariate Analysis and Regression. Lymphocyte count and co-morbidities were evaluated in the whole cohort, albumin levels in 1437 patients. In the whole sample, low albumin levels and low lymphocyte counts were directly correlated to longer hospitalizations. The stratification of the results by department and diagnosis suggests that there is a higher correlation in certain subpopulations, and albumin shows a greater correlation with length of stay than lymphocytes. Also advanced age, high platelets, type of diagnosis, male gender and emergency admission led to longer hospitalizations. A routine check of albumin, lymphocytes and a spectrum of significant variables can provide precious information which can eventually lead to a shorter hospital stay. Knowledge of the general health status of a patient and the possibility to estimate his/her length of hospital stay are essential information for Clinical Governance, and for the improvement of internal services of hospitals on a large scale.

Connective tissue diseases and noninvasive evaluation of atherosclerosis

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Ardita G

2014-06-01

Full Text Available Giorgio Ardita, Giacomo Failla, Paolo Maria Finocchiaro, Francesco Mugno, Luigi Attanasio, Salvatore Timineri, Michelangelo Maria Di SalvoCardiovascular Department, Angiology Unit, Ferrarotto Hospital, Catania, ItalyAbstract: Connective tissue diseases (CTDs are associated with increased risk of cardiovascular disease due to accelerated atherosclerosis. In patients with autoimmune disorders, in addition to traditional risk factors, an immune-mediated inflammatory process of the vasculature seems to contribute to atherogenesis. Several pathogenetic mechanisms have been proposed, including chronic inflammation and immunologic abnormalities, both able to produce vascular damage. Macrovascular atherosclerosis can be noninvasively evaluated by ultrasound measurement of carotid or femoral plaque. Subclinical atherosclerosis can be evaluated by well-established noninvasive techniques which rely on ultrasound detection of carotid intima-media thickness. Flow-mediated vasodilatation and arterial stiffness are considered markers of endothelial dysfunction and subclinical atherosclerosis, respectively, and have been recently found to be impaired early in a wide spectrum of autoimmune diseases. Carotid intima-media thickness turns out to be a leading marker of subclinical atherosclerosis, and many studies recognize its role as a predictor of future vascular events, both in non-CTD individuals and in CTD patients. In rheumatic diseases, flow-mediated dilatation and arterial stiffness prove to be strongly correlated with inflammation, disease damage index, and with subclinical atherosclerosis, although their prognostic role has not yet been conclusively shown. Systemic lupus erythematosus, rheumatoid arthritis, and likely antiphospholipid syndrome are better associated with premature and accelerated atherosclerosis. Inconclusive results were reported in systemic sclerosis.Keywords: rheumatic disease, subclinical atherosclerosis, arterial stiffness

Comparative effectiveness of liraglutide in the treatment of type 2 diabetes

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Rigato M

2014-03-01

Full Text Available Mauro Rigato, Gian Paolo Fadini Department of Medicine, University Hospital of Padova, Padova, Italy Abstract: Type 2 diabetes is characterized by a progressive decline in beta cell function, with consequent worsening of glycemic control. The ideal antihyperglycemic treatment should achieve good and sustained glycemic control, with a low risk of hypoglycemia and no weight gain. This paper reviews the efficacy and tolerability of liraglutide, a glucagon-like peptide-1 receptor agonist approved for the treatment of type 2 diabetes. Once-daily injection of liraglutide (at doses of 1.2 mg and 1.8 mg, as monotherapy or in combination with one or two oral antihyperglycemic agents, was associated with greater improvements in glycemic control compared with active comparators or placebo in several controlled, randomized Phase III trials, including the six trials of the LEAD (Liraglutide Effect and Action in Diabetes program. Liraglutide also improved beta cell function, body weight, systolic blood pressure, and lipid profile, thereby achieving many of the goals of ideal antihyperglycemic therapy. Liraglutide was generally well tolerated in the Phase III trials. The most common adverse events were nausea, vomiting, and diarrhea, usually of mild to moderate intensity. The observed rate of pancreatitis was low and comparable with that of the general diabetic population. In conclusion, although most trials were relatively short and focused on surrogate endpoints, liraglutide emerges as an effective and well tolerated treatment for type 2 diabetes, carrying a low risk of hypoglycemia, weight loss, and possible reduction of cardiovascular risk. Keywords: body weight, hypoglycemia, cardiovascular, incretin

"Media, politics and science policy: MS and evidence from the CCSVI Trenches".

Science.gov (United States)

Pullman, Daryl; Zarzeczny, Amy; Picard, André

2013-02-12

In 2009, Dr. Paolo Zamboni proposed chronic cerebrospinal venous insufficiency (CCSVI) as a possible cause of multiple sclerosis (MS). Although his theory and the associated treatment ("liberation therapy") received little more than passing interest in the international scientific and medical communities, his ideas became the source of tremendous public and political tension in Canada. The story moved rapidly from mainstream media to social networking sites. CCSVI and liberation therapy swiftly garnered support among patients and triggered remarkable and relentless advocacy efforts. Policy makers have responded in a variety of ways to the public's call for action. We present three different perspectives on this evolving story, that of a health journalist who played a key role in the media coverage of this issue, that of a health law and policy scholar who has closely observed the unfolding public policy developments across the country, and that of a medical ethicist who sits on an expert panel convened by the MS Society of Canada and the Canadian Institutes of Health Research to assess the evidence as it emerges. This story raises important questions about resource allocation and priority setting in scientific research and science policy. The growing power of social media represents a new level of citizen engagement and advocacy, and emphasizes the importance of open debate about the basis on which such policy choices are made. It also highlights the different ways evidence may be understood, valued and utilized by various stakeholders and further emphasizes calls to improve science communication so as to support balanced and informed decision-making.

Photogrammetry: an accurate and reliable tool to detect thoracic musculoskeletal abnormalities in preterm infants.

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Davidson, Josy; dos Santos, Amelia Miyashiro N; Garcia, Kessey Maria B; Yi, Liu C; João, Priscila C; Miyoshi, Milton H; Goulart, Ana Lucia

2012-09-01

To analyse the accuracy and reproducibility of photogrammetry in detecting thoracic abnormalities in infants born prematurely. Cross-sectional study. The Premature Clinic at the Federal University of São Paolo. Fifty-eight infants born prematurely in their first year of life. Measurement of the manubrium/acromion/trapezius angle (degrees) and the deepest thoracic retraction (cm). Digitised photographs were analysed by two blinded physiotherapists using a computer program (SAPO; http://SAPO.incubadora.fapesp.br) to detect shoulder elevation and thoracic retraction. Physical examinations performed independently by two physiotherapists were used to assess the accuracy of the new tool. Thoracic alterations were detected in 39 (67%) and in 40 (69%) infants by Physiotherapists 1 and 2, respectively (kappa coefficient=0.80). Using a receiver operating characteristic curve, measurement of the manubrium/acromion/trapezius angle and the deepest thoracic retraction indicated accuracy of 0.79 and 0.91, respectively. For measurement of the manubrium/acromion/trapezius angle, the Bland and Altman limits of agreement were -6.22 to 7.22° [mean difference (d)=0.5] for repeated measures by one physiotherapist, and -5.29 to 5.79° (d=0.75) between two physiotherapists. For thoracic retraction, the intra-rater limits of agreement were -0.14 to 0.18cm (d=0.02) and the inter-rater limits of agreement were -0.20 to -0.17cm (d=0.02). SAPO provided an accurate and reliable tool for the detection of thoracic abnormalities in preterm infants. Copyright © 2011 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

Giuseppe Sergi. The portrait of a positivist scientist.

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Cerro, Giovanni

2017-12-30

Giuseppe Sergi (1841-1936) was one of the most important anthropologists and psychologists of the age of positivism and this article focuses on three domains of his scientific research: degeneration, eugenics and race. His concept of degeneration is defined as the development of special forms of human adaptation to the environment. This issue is closely related to his theory of the "stratification of character", which had a profound impact on Italian psychiatry and criminal anthropology in the late nineteenth century. Thus, special emphasis is placed on the differences between Sergi and Cesare Lombroso regarding their definitions of criminality and genius. Concerning eugenics, the article analyzes Sergi's key role in the Italian context, discussing his eugenic program based on both repression and education. His remedies against the spread of degeneration included not only radical and repressive measures, but also the improvement of popular education and the living conditions of the working class. In the field of physical anthropology, the article examines Sergi's morphological method of classifying ethnic groups. Although sharply criticized in Italy and abroad, this method had two major effects. First, it led to the definitive split between Sergi and Paolo Mantegazza and to the foundation of the Societá Romana di Antropologia in 1893. Second, it was the starting point for Sergi's theory of Mediterranean "stock", which claimed that European populations were of African origin in contrast to contemporary theories of Aryan supremacy. The article ends with a look at the heated debate over Sergi's Mediterraneanism during the period of Fascism.

The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation

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Paolo Gelosa

2007-11-01

Full Text Available Paolo Gelosa1, Mauro Cimino2, Alice Pignieri1, Elena Tremoli1,3, Uliano Guerrini1, Luigi Sironi11Department of Pharmacological Sciences, University of Milan, Italy; 2Institute of Pharmacological Sciences, Carlo Bo University of Urbino, Italy; 3Monzino Cardiologic Center IRCCS, Milan, ItalyAbstract: Statin-induced inhibition of HMG-CoA reductase reduces cholesterol production and prevents the formation of many non-steroidal isoprenoid compounds, such as farnesylpyrophosphate and geranylgeranylpyrophosphate, that act as lipid attachments for the post-translational modification of various proteins, including the G-proteins and transcription factors involved in a number of cell processes. However, the blockade of isoprenylation elicited by statin treatment also has biological effects on cell function that go beyond the decrease in cholesterol synthesis: these are the so-called “pleiotropic” effects that mainly relate to vascular function. Endothelial dysfunction is an independent predictor of cardiovascular events that correlates with inflammation markers/mediators and robust predictors of cardiovascular diseases such as increased high-sensitivity C-reactive protein levels. The results of in vivo and in vitro studies indicate that the statins have beneficial effects unrelated to cholesterol lowering, such as improving endothelial function, increasing myocardial perfusion, and enhancing the availability of nitric oxide. This review describes the pleiotropic effects of statins that may be involved in modulating/preventing endothelial dysfunction and inflammatory processes, as well as the cellular and molecular mechanisms through which they improve endothelial function.Keywords: statins; inflammation; endothelial dysfunction; nitric oxide; HMG-CoA reductase

Nanoparticle–allergen complexes for allergen immunotherapy

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Di Felice G

2017-06-01

Full Text Available Gabriella Di Felice,1 Paolo Colombo2 1National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, 2Institute of Biomedicine and Molecular Immunology, National Research Council, Palermo, Italy Abstract: Allergen-specific immunotherapy was introduced in clinical settings more than 100 years ago. It remains the only curative approach to treating allergic disorders that ameliorates symptoms, reduces medication costs, and blocks the onset of new sensitizations. Despite this clinical evidence and knowledge of some immunological mechanisms, there remain some open questions regarding the safety and efficacy of this treatment. This suggests the need for novel therapeutic approaches that attempt to reduce the dose and frequency of treatment administration, improving patient compliance, and reducing costs. In this context, the use of novel adjuvants has been proposed and, in recent years, biomedical applications using nanoparticles have been exploited in the attempt to find formulations with improved stability, bioavailability, favorable biodistribution profiles, and the capability of targeting specific cell populations. In this article, we review some of the most relevant regulatory aspects and challenges concerning nanoparticle-based formulations with immunomodulatory potential, their related immunosafety issues, and the nature of the nanoparticles most widely employed in the allergy field. Furthermore, we report in vitro and in vivo data published using allergen/nanoparticle systems, discuss their impact on the immune system in terms of immunomodulatory activity and the reduction of side effects, and show that this strategy is a novel and promising tool for the development of allergy vaccines. Keywords: allergy, nanocarriers, immunotoxicity, immune modulation, immunotherapy, allergens

Endoscopic treatment of cerebrospinal fluid leaks with the use of lower turbinate grafts: a retrospective review of 125 cases.

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Cassano, Michele; Felippu, Alexandre

2009-12-01

Endoscopic transnasal approaches to the skull base have revolutionized the treatment of cerebrospinal fluid (CSF) fistulae, making repair less invasive and more effective compared with craniotomy or extracranial techniques. This study evaluated, retrospectively, the results of endoscopic repair of dural defects with the use of mucoperiostal grafts taken from the lower turbinate. Between January 1997 and January 2007, 125 cases of anterior skull base CSF fistulae were treated endoscopically at the Instituto Felippu de Otorrinolaringologia, Sao Paolo, Brazil, and at the Department of Otolaryngology of the University Hospital "Ospedali Riuniti", Foggia, Italy. Fistula closure was achieved by overlay apposition of a lower turbinate mucoperiostal graft fixated with fibrin glue and Surgicell. The etiology of the fistula was accidental trauma in 41 cases, iatrogenic trauma in 29, skull base tumour in 12, and spontaneous in 43. The site of the defect was the sphenoid sinus in 43 patients, the cribriform plate in 42, the anterior ethmoid roof in 21, the posterior ethmoid roof in 17, and the posterior wall of the frontal sinus in 2. The success rate at first attempt was 94.4%; the 7 cases of postoperative recurrent CSF leakage involved patients presenting with spontaneous fistula and elevated intracranial pressure; 5 of these had a body-mass index > 30 and 3 suffered from diabetes mellitus. In our hands, the success rate of endoscopic fistula repair was high, even in defects larger than 2 cm. Success rates may be further improved with accurate diagnosis of elevated intracranial pressure, a contributing factor to failure of spontaneous fistula repair.

„This is just a fucking movie. Also fahrt ab damit!“ Eine Rezensionsreise durch Abel Ferraras Film ‚Pasolini‘, anlässlich des 40. Todestages von Pier Paolo Pasolini

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Angela Oster

2015-06-01

Full Text Available Das Leben Pasolinis ist bereits zu wiederholten Malen der Gegenstand von Texten und Filmen gewesen. Aufgrund des skandalträchtigen Todes des Linksintellektuellen – er wurde unter nie genau geklärten Umständen 1975 ermordet – ranken sich viele Mythen um den letzten Tag Pasolinis. Genau diesen 'ultimo giorno' verfilmt Abel Ferrara (1914 und setzt dabei eigene Akzente. Mit literar- und dokumentargenauer Perspektive bietet Ferrara gleichwohl innovative Interpretationen in Hinblick auf einen der wichtigsten Künstler Italiens.

Cardiotoxic effects of the novel approved anti-ErbB2 agents and reverse cardioprotective effects of ranolazine

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De Lorenzo C

2018-04-01

Full Text Available Claudia De Lorenzo,1,2,* Rolando Paciello,1,2,* Gennaro Riccio,3 Domenica Rea,4 Antonio Barbieri,4 Carmela Coppola,4 Nicola Maurea4 1Department of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Naples, Italy; 2Ceinge, Biotecnologie Avanzate s.c.a.r.l., Naples, Italy; 3Department of Pharmacy, Federico II University, Naples, Italy; 4Division of Cardiology, Istituto Nazionale Tumori – Irccs Fondazione G. Pascale, Naples, Italy *These authors contributed equally to this work Purpose: Pertuzumab, a novel anti-epidermal growth factor receptor 2 humanized monoclonal antibody, and trastuzumab-emtansine (TDM1, a novel antibody–drug conjugate made up of trastuzumab covalently linked to the highly potent microtubule inhibitory agent DM1, have been recently approved by the US Food and Drug Administration for increasing the efficiency and safety of breast cancer therapy with trastuzumab. We investigated for the first time the potential cardiotoxic effects of pertuzumab and TDM1, which are not yet fully elucidated, and we tested whether ranolazine could blunt their cardiotoxicity.Methods: The cardiotoxic effects were tested in vitro on rat cardiomyoblasts, human fetal cardiomyocytes, adult-like cardiomyocytes, and in vivo on a mouse model.Results: All the treated cardiac cell lines were significantly affected by treatment with the tested drugs. Surprisingly, TDM1 showed stronger inhibitory effects on cardiac cells with respect to trastuzumab and pertuzumab by more significantly reducing the cell viability and by changing the morphology of these cells. TDM1 also affected the beating phenotype of adult-like cardiomyocytes in vitro and reduced fractional shortening and ejection fraction in vivo in a mouse model. We also found that ranolazine attenuated not only the cardiotoxic side effects of trastuzumab but also those of pertuzumab and TDM1, when used in combinatorial treatments both in vitro and in vivo, as

Antineoplastic-related cardiotoxicity, morphofunctional aspects in a murine model: contribution of the new tool 2D-speckle tracking

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Coppola C

2016-11-01

Full Text Available Carmela Coppola,1 Gennaro Riccio,1 Antonio Barbieri,2 Maria Gaia Monti,3 Giovanna Piscopo,1 Domenica Rea,2 Claudio Arra,2 Carlo Maurea,1 Claudia De Lorenzo,4,5 Nicola Maurea1 1Division of Cardiology, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”, IRCCS, Naples, Italy; 2Animal Facility Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”, IRCCS, Naples, Italy; 3Department of Translational Medical Sciences, University Federico II, Naples, Italy; 4Department of Molecular Medicine and Medical Biotechnology, University Federico II, Naples, Italy; 5CEINGE Biotecnologie Avanzate, Naples, Italy Objective: Considering that global left ventricular systolic radial strain is a sensitive technique for the early detection of left ventricular dysfunction due to antineoplastics and the analysis of segmental myocardial contractility, we evaluated this technique for early detection of trastuzumab-related cardiotoxicity by comparing it with cardiac structural damage.Methods: Groups of six mice were injected with trastuzumab or doxorubicin, used either as single agents or in combination. Cardiac function was evaluated by transthoracic echocardiography measurements before and after treatment for 2 or 7 days, by using a Vevo 2100 high-resolution imaging system. After echocardiography, mice were euthanized, and hearts were processed for histological evaluations, such as cardiac fibrosis, apoptosis, capillary density, and inflammatory response.Results: Trastuzumab-related cardiotoxicity was detected early by 2D strain imaging. Radial strain was reduced after 2 days in mice treated with trastuzumab alone (21.2%±8.0% vs 40.5%±4.8% sham; P<0.01. Similarly, trastuzumab was found to induce apoptosis, capillary density reduction, and inflammatory response in cardiac tissue after 2 days of treatment, in a fashion similar to doxorubicin. On the contrary, fractional

Chiral three-nucleon forces and the evolution of correlations along the oxygen isotopic chain

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Cipollone, A.; Barbieri, C.; Navrátil, P.

2015-07-01

Background: Three-nucleon forces (3NFs) have nontrivial implications on the evolution of correlations at extreme proton-neutron asymmetries. Recent ab initio calculations show that leading-order chiral interactions are crucial to obtain the correct binding energies and neutron driplines along the O, N, and F chains [A. Cipollone, C. Barbieri, and P. Navrátil, Phys. Rev. Lett. 111, 062501 (2013), 10.1103/PhysRevLett.111.062501]. Purpose: Here we discuss the impact of 3NFs along the oxygen chain for other quantities of interest, such has the spectral distribution for attachment and removal of a nucleon, spectroscopic factors, and radii. The objective is to better delineate the general effects of 3NFs on nuclear correlations. Methods: We employ self-consistent Green's function (SCGF) theory which allows a comprehensive calculation of the single-particle spectral function. For the closed subshell isotopes, 14O, 16O, 22O, 24O, and 28O, we perform calculations with the Dyson-ADC(3) method, which is fully nonperturbative and is the state of the art for both nuclear physics and quantum chemistry applications. The remaining open-shell isotopes are studied using the newly developed Gorkov-SCGF formalism up to second order. Results: We produce complete plots for the spectral distributions. The spectroscopic factors for the dominant quasiparticle peaks are found to depend very little on the leading-order (NNLO) chiral 3NFs. The latter have small impact on the calculated matter radii, which, however, are consistently obtained smaller than experiment. Similarly, single-particle spectra tend to be too spread with respect to the experiment. This effect might hinder, to some extent, the onset of correlations and screen the quenching of calculated spectroscopic factors. The most important effect of 3NFs is thus the fine tuning of the energies for the dominant quasiparticle states, which governs the shell evolution and the position of driplines. Conclusions: Although present chiral

La inocencia de Giulio. Andreotti no fue absuelto

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Giulio Cavalli

2016-01-01

Full Text Available Desde su espectáculo solista Kabum!... come un paio di impossibilità (2006, estrenado bajo la dirección artística de Paolo Rossi, la dramaturgia de Giulio Cavalli (Milán, 1977 se ha caracterizado por tener una fuerte orientación cívica. Dos de sus obras de ese mismo año, 2006, pueden dar cuenta de ello: (Re Carlo (non torna dalla battaglia di Poitiers, sobre los trágicos hechos ocurridos durante la reunión del G8 en Génova en 2001, y Linate 8 ottobre 2001: la strage, sobre el acccidente aéreo que costó la vida a 118 pesonas. Aunque posteriormente ha ampliado su teatro a otros temas, como en Bambini a dondolo (2007, un drama sobre el turismo sexual infantil, han sido sus intensos espectáculos sobre la mafia los que han acabado por darle no solo una mayor repercusión, sino también la obligación de vivir desde entonces bajo escolta policial antes las continuas amenazas y planes de asesinato por parte de la 'Ndrangheta. Entre las obras de esta temática destacan Do ut Des (2009 o la que aquí presentamos, L'innocenza di Giulio (2011, más tarde convertida en libro con el título L'innocenza di Giulio: Andreotti e la mafia (Milán: Chiarelettere, 2012. Para su último proyecto, L’amico degli eroi, sobre las conexiones con la mafia de Marcello dell'Utri, ha contado, al igual que en los anteriores, con el acompañamiento musical de Cisco Bellotti.

Imaginary politics: Climate change and making the future

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Manjana Milkoreit

2017-11-01

Full Text Available Climate change places major transformational demands on modern societies. Transformations require the capacity to collectively envision and meaningfully debate realistic and desirable futures. Without such a collective imagination capacity and active deliberation processes, societies lack both the motivation for change and guidance for decision-making in a certain direction of change. Recent arguments that science fiction can play a role in societal transformation processes is not yet supported by theory or empirical evidence. Advancing the argument that fiction can support sustainability transformations, this paper makes four contributions. First, building on the imaginary concept, I introduce and define the idea of socio-climatic imaginaries. Second, I develop a theory of imagination as linked cognitive-social processes that enable the creation of collectively shared visions of future states of the world. This theory addresses the dynamics that bridge imagination processes in the individual mind and collective imagining that informs social and political decision-making. Third, emphasizing the political nature of creating and contesting imaginaries in a society, I introduce the role of power and agency in this theory of collective imagination. I argue that both ideational and structural power concepts are relevant for understanding the potential societal influence of climate fiction. Finally, the paper illuminates these different forms of transformational power and agency with two brief case studies: two climate fiction novels. I contrast a dystopian and utopian science fiction novel – Paolo Bacigalupi’s The Water Knife (2015 and Kim Stanley Robinson's Green Earth (2015. The two books are very similar in their power/agency profile, but the comparison provides initial insights into the different roles of optimistic and pessimistic future visions.

Narrative medicine to improve the management and quality of life of patients with COPD: the first experience applying parallel chart in Italy

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Banfi P

2018-01-01

Full Text Available Paolo Banfi,1 Antonietta Cappuccio,2 Maura E Latella,3 Luigi Reale,2 Elisa Muscianisi,3 Maria Giulia Marini2 1Pneumological Rehabilitation, IRCCS Fondazione Don Gnocchi Onlus, Milan, Italy; 2Healthcare Area, Fondazione ISTUD, Milan, Italy; 3Medical Department, Novartis Farma Spa, Origgio, Italy Purpose: Poor adherence to therapy and the failure of current smoking cessation programs demonstrate that the current management of COPD can be improved, and it is necessary to educate physicians about new approaches for taking care of patients. Parallel chart is a narrative medicine tool that improves the doctor–patient relationship by asking physicians to write about their patients’ lives, thereby encouraging reflective thoughts on care. Patients and methods: Between October 2015 and March 2016, 50 Italian pulmonologists were involved in the collection of parallel charts of anonymous patients with COPD. The narratives were analyzed according to the Grounded Theory methodology. Results: In the 243 parallel charts collected, the patients (mean age 69 years, 68% men are described as still active and as a resource for their families (71%. The doctor–patient relationship started as difficult in 50% of cases, and younger age and smoking were the main risk factors. The conversations turned positive in 78% of narratives, displaying deeper mutual knowledge, trust for the clinicians’ ability to establish effective therapy (92%, support efforts to quit smoking (63%, or restore patients’ activities (78%.Conclusion: All the physicians concurred that the adoption of innovative parallel charts was useful for improving clinical care and worthy of official inclusion in protocols for the management of COPD. Keywords: narrative medicine, COPD, doctor–patient relationship, quality of life

Book review. Conoscere gli animali familiari. Francesca Bellini, Alessia Liverini, Vincenzo Rosa

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Manuel Graziani

2014-03-01

Full Text Available Conoscere gli animali familiari è la settima uscita della collana diretta da Paolo Polidori "produzioni animali e sicurezza alimentare" sulla ricerca nell'ambito della nutrizione e alimentazione animale, zootecnia, ispezione degli alimenti di origine animale, clinica medica e parassitologia veterinaria con risvolti di natura tecnica, scientifica e pratica. Il volume, redatto da medici veterinari in servizio presso differenti Aziende Sanitarie italiane, è un sintetico manuale su domesticazione, cura sanitaria, etnografia e addestramento del proprio cane (o gatto. Gli autori partono dall'assunto che i proprietari scelgono il cane per lo più sulla base del gusto visivo o sulla consuetudine tramandata in famiglia, senza un'esaustiva conoscenza degli aspetti riguardanti l'origine dell'animale, la sua attitudine prevalente, le sue patologie ricorrenti e le eventuali predisposizioni genetiche nei confronti di una determinata patologia. Puntano l'accento sin dalle prime battute sul cambiamento culturale che ha modificato anche il rapporto uomo-animale sotto l'aspetto sociale, effettuale e giuridico. L'animale da semplice "res" si è da tempo affermato come un essere diverso ma senziente, quindi destinatario di tutele, con diritti contemplati dalle carte costituzionali di diversi Paesi. Per questo motivo chi detiene un animale domestico deve prepararsi ad un impegno non riducibile al possesso di un oggetto, al punto di risponderne penalmente per eventuali sofferenze fisiche o psicologiche, per l'abbandono (anche solo temporaneo o per l'incuria. Conoscere gli animali familiari fornisce nozioni scientifiche e sanitarie alla portata di tutti, utili soprattutto nelle occasioni in cui i proprietari dovranno recarsi dal veterinario o affrontare visite legate alla profilassi e alle vaccinazioni di routine.

Scholars and scientists in the history of the lymphatic system.

Science.gov (United States)

Natale, Gianfranco; Bocci, Guido; Ribatti, Domenico

2017-09-01

The discovery of the lymphatic system has a long and fascinating history. The interest in anatomy and physiology of this system paralleled that of the blood cardiocirculatory system and has been maybe obscured by the latter. Paradoxically, if the closed blood system appeared open in Galen's anatomy and physiology, and took a very long time to be correctly described in terms of pulmonary and general circulation by ibn Al-Nafis/Michael Servetus/Realdo Colombo and William Harvey, respectively, the open lymphatic system was incorrectly described as a closed circuit connected with arteries and veins. In ancient times only macroscopic components of the lymphatic system have been described, although misinterpreted, including lymph nodes and lacteals, the latter being easily identified because of their milk-like content. For about 15 centuries the dogmatic acceptance of Galen's notions did not allow a significant progress in medicine. After Vesalius' revolution in anatomical studies, new knowledge was accumulated, and the 17th century was the golden age for the investigation of the lymphatic system with several discoveries: gut lacteals (Gaspare Aselli), cloacal bursa (Hieronimus Fabricius of Acquapendente), reservoir of the chyle (Jean Pecquet), extra-intestinal lymphatic vessels (Thomas Bartholin and Olaus Rudbeck dispute), hepatic lymph circulation (Francis Glisson). In the Enlightenment century Frederik Ruysch described the function of lymphatic valves, and Paolo Mascagni provided a magnificent iconography of the lymphatic network in humans. In recent times, Leonetto Comparini realized three-dimensional reconstructions of the liver lymphatic vessels, and Kari Alitalo discovered the lymphatic growth factor/receptor system. Far from a complete understanding of its anatomy and function, the lymphatic system still needs to be profoundly examined. © 2017 Anatomical Society.

Information letter 2. Information about operation of plants SE-NPP Bohunice and SE-VYZ during February 2005

International Nuclear Information System (INIS)

2005-03-01

In this leaflet results of exploitation of four units of the Bohunice V-1 and V-2 NPPs are presented. The electricity and heat production in February 2005 are reviewed. Within a February 2005 the electricity was produced: 217 GWh (block 1), 281 GWh (block 2), 277 GWh (block 3), 282 GWh (block 4), totally 1057 GWh, and 2271 GWh within a January - February 2005. The heat production in February 2005 was 266 506 GJ, and within a January - February 2005 it was produced 531 849 GJ of heat. On February 17 Slovak minister of economy Pavol Rusko and general director of ENEL Paolo Scaroni signed the agreement on acquisition of 66 per cent of Slovenske elektrarne (SE) by Italian ENEL for 840 million Eur. SE has capacity of around 7 GW (83 per cent of total Slovakian capacity). In 2004 SE generated 26 TWh of electricity. Processing and storage of radioactive wastes in Decommissioning of Nuclear Installations and Spent Fuel and Rad-waste Management (SE-VYZ) is presented. Since beginning of this year 58 fibre-concrete containers have been filled up in Bohunice processing centre of radioactive wastes. Twenty-three pieces of fibre-concrete containers were processed into fibre-concrete containers in Bohunice processing centre of radioactive wastes (BSC RAO) in February 2005. Twenty fibre-concrete containers were stored into Republic storage of radioactive wastes (RU RAO). Total number in RU RAO reached 830 pieces of fibre-concrete containers, which represent 11.53 per cent of storage capacity (7200 containers). Bohunice processing centre of radioactive wastes was put into active operation just before five years

Management of chemotherapy-induced nausea and vomiting by risk profile: role of netupitant/palonosetron

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Lorusso V

2016-06-01

Full Text Available Vito Lorusso National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Bari, Italy Abstract: As recommended by most recent antiemetic guidelines, the optimal prophylaxis of chemotherapy-induced nausea and vomiting (CINV requires the combination of 5-HT3 receptor antagonist (RA with an NK1-RA. Moreover, the major predictors of acute and delayed CINV include: young age, female sex, platinum- or anthracycline-based chemotherapy, nondrinker status, emesis in the earlier cycles of chemotherapy, and previous history of motion/morning sickness. Despite improved knowledge of the pathophysiology of CINV and advances in the availability of active antiemetics, an inconsistent compliance with their use has been reported, thereby resulting in suboptimal control of CINV in several cases. In this scenario, a new antiemetic drug is now available, which seems to be able to guarantee better prophylaxis of CINV and improvement of adherence to guidelines. In fact, netupitant/palonosetron (NEPA is a ready-to-use single oral capsule, combining an NK1-RA (netupitant and a 5-HT3-RA (palonosetron, which is to be taken 1 hour before the administration of chemotherapy, ensuring the coverage from CINV for 5 days. We reviewed the role of NEPA in patients at high risk of CINV receiving highly emetogenic chemotherapy. In these patients, NEPA plus dexamethasone, as compared to standard treatments, achieved superior efficacy in all primary and secondary end points during the acute, delayed, and overall phases, including nausea assessment. Moreover, these results were also achieved in female patients receiving anthracycline plus cyclophosphamide-based chemotherapy. NEPA represents a real step forward in the prophylaxis of CINV. Keywords: NEPA, netupitant, NK1, CINV, vomiting, risk factors

Soft qualities in healthcare. Method and tools for soft qualities design in hospitals' built environments.

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Capolongo, S; Bellini, E; Nachiero, D; Rebecchi, A; Buffoli, M

2014-01-01

The design of hospital environments is determined by functional requirements and technical regulations, as well as numerous protocols, which define the structure and system characteristics that such environments need to achieve. In order to improve people's well-being and the quality of their experience within public hospitals, design elements (soft qualities) are added to those 'necessary' features. The aim of this research has been to experiment a new design process and also to create health care spaces with high environmental quality and capable to meet users' emotional and perceptual needs. Such needs were investigated with the help of qualitative research tools and the design criteria for one of these soft qualities - colour - were subsequently defined on the basis of the findings. The colour scheme design for the new San Paolo Hospital Emergency Department in Milan was used as case study. Focus groups were fundamental in defining the project's goals and criteria. The issues raised have led to believe that the proper procedure is not the mere consultation of the users in order to define the goals: users should rather be involved in the whole design process and become co-agents of the choices that determine the environment characteristics, so as to meet the quality requirements identified by the users themselves. The case study has shown the possibility of developing a designing methodology made by three steps (or operational tools) in which users' groups are involved in the choices, loading to plan the environments where compliance with expectations is already implied and verified by means of the process itself. Thus, the method leads to the creation of soft qualities in Healthcare.

As Técnicas de Reintegração Cromática na Pintura: revisão historiográfica

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Ana Bailão

2011-12-01

Full Text Available Laura Mora, Paolo Mora e Paul Philippot escreveram, por ocasião da primeira edição de Conservation des peintures murales, em 1975, que o tratteggio nunca tinha sido publicado em nenhuma revista técnica e que, apesar de ser praticado desde 1945, consideravam que ainda não tinha sido devidamente entendido, motivo pelo qual tentavam-no descrever detalhadamente. No inicio da segunda década do século XXI, várias são as situações, no caso concreto da reintegração cromática, em que persistem problemas de terminologia e alguma confusão acerca das técnicas de reintegração aplicadas em pintura, quer no discurso escrito, quer no discurso oral. Por esse motivo, o principal objectivo deste artigo é esclarecer a origem e os procedimentos originais de execução de algumas técnicas de reintegração cromática, as que normalmente se usam em pintura de cavalete em Portugal, tentando recorrer às fontes originais e a estudos específicos sobre o tema, bem como anotar particularidades na evolução das mesmas. O segundo propósito deste texto é facultar esta informação em língua portuguesa, algo inexistente até agora. Com base na interpretação das fontes bibliográficas concluiu-se que a mesma técnica pode ser praticada de modo diferente consoante a nacionalidade do conservador-restaurador, contribuindo para a evolução das técnicas existentes e para o aparecimento de outras.

Syncope in old people. The importance of multiparametric monitor in OBI evaluation

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Alessandro Riccardi

2006-10-01

Full Text Available Syncope is a common clinical entity, and it causes up to 3% of admission in the Emergency Department. The evaluation of syncope begins with a careful history, physical examination, and electrocardiography, with a correct identification of etiology at the presentation in up to 50% of cases. Moreover, the underlying cause of syncope remains unidentified in a elevated percentage of patients. The application of Standard Guidelines and the institution of the Observation Unit (OBI with continuous monitoring improves patients management, chiefly in the geriatric population (> 65 years old. In older patients the clinical features of syncope are less defined, and the medical history has a limited value. The management in the OBI of this group of patient with continuous monitoring could become the best approach. The ECG monitoring can detect life-threatening arrhythmias in older patients with apparent non cardiac syncope. In the firs six months of 2005 the Emergency Department of the Ospedale San Paolo (Savona evaluated 164 patients > 65 years old with diagnosis of syncope/pre-syncope. During monitoring we detected events of arrhythmia in 12 patients (7,3%, including ventricular tachycardia in 2, atrial fibrillation in 4, paroxysmal atrial flutter in 2, paroxysmal supraventricular tachycardia in 1, asystole in 1 and third-degree atrioventricular block in 2 patients. We briefly describe 2 of this case: in both cases the first suggestion indicates a possible non cardiac etiology, but the subsequent monitoring shows episodes of potentially fatal arrhythmia. Both an early discharge and an in non-monitorized bed admission wouldn’t have preserved the two patient by a sudden cardiac death.

Spatial analysis of homicides in South East Brazil: An assessment of differential risk between men, women, and the youth / Analyse des homicides dans la région du Sud-Est du Brésil : une évaluation des risques différentiels chez les hommes, les femmes et les jeunes

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Diniz Alves Alexandre Magno

2012-10-01

Full Text Available Cette étude se base sur une perspective géographique et analyse l’évolution dans l’espace et dans le temps des taux moyens de morts par homicide dans la région du Sud-Est du Brésil, entre 2001 et 2008, chez les hommes, les femmes, les jeunes entre 15 et 29 ans, et l’ensemble de la population. Les résultats mettent en évidence que ce phénomène touche de manière asymétrique les jeunes hommes, tandis que chez les femmes les taux moyens sont les plus bas. L’analyse dans l’espace a souligné qu’il existe des zones avec des taux d’homicide élevés et stabilisés dans le temps, comme les régions métropolitaines de Rio de Janeiro et Vitória. En revanche, l’étude a montré qu’entre les régions métropolitaines de Belo Horizonte (RMBH, Campinas et San Paolo, les dynamiques sont différentes. This study is based on a geographical perspective and explores the spatial and temporal evolution of average homicide rates in Southeast Brazil, between 2001 and 2008 for different subpopulations (male, female, youth, and total population. Results show that this phenomenon affects asymmetrically young males, while women have the lowest average rates. Spatial analysis pinpoints consolidated areas with high homicide rates, such as the metropolitan areas of Rio de Janeiro and Vitoria. On the other hand, different dynamics can be observed among the metropolitan areas of Belo Horizonte (BHMA, Campinas and Sao Paulo.

Energy Frontier Research Centers: A View from Senior EFRC Representatives (2011 EFRC Summit, panel session)

International Nuclear Information System (INIS)

Drell, Persis; Armstrong, Neal; Carter, Emily; DePaolo, Don; Gunnoe, Brent

2011-01-01

A distinguished panel of scientists from the EFRC community provide their perspective on the importance of EFRCs for addressing critical energy needs at the 2011 EFRC Summit. Persis Drell, Director at SLAC, served as moderator. Panel members are Neal Armstrong (Director of the Center for Interface Science: Solar Electric Materials, led by the University of Arizona), Emily Carter (Co-Director of the Combustion EFRC, led by Princeton University. She is also Team Leader of the Heterogeneous Functional Materials Center, led by the University of South Carolina), Don DePaolo (Director of the Center for Nanoscale Control of Geologic CO2, led by LBNL), and Brent Gunnoe (Director of the Center for Catalytic Hydrocarbon Functionalization, led by the University of Virginia). The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss 'Science for our Nation's Energy Future.' In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate

Targeted dual-color silica nanoparticles provide univocal identification of micrometastases in preclinical models of colorectal cancer

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Soster M

2012-09-01

Full Text Available Marco Soster,1,* Riccardo Juris,2,* Sara Bonacchi,2 Damiano Genovese,2 Marco Montalti,2 Enrico Rampazzo,2 Nelsi Zaccheroni,2 Paolo Garagnani,2 Federico Bussolino,3,4 Luca Prodi,2 Serena Marchiò1,4 1Institute for Cancer Research and Treatment, Laboratory of Tumor Microenvironment and University of Torino, Department of Oncological Sciences, Candiolo, 2University of Bologna, Department of Chemistry "G.Ciamician", Bologna, 3Institute for Cancer Research and Treatment, Laboratory of Vascular Oncology and University of Torino, Department of Oncological Sciences, Candiolo, 4APAvadis Biotechnologies, BioIndustry Park S Fumero, Colleretto Giacosa, Italy*These authors equally contributed to the workBackground and methods: Despite the recent introduction of targeted bio-drugs, the scarcity of successful therapeutic options for advanced colorectal cancer remains a limiting factor in patient management. The efficacy of curative surgical interventions can only be extended through earlier detection of metastatic foci, which is dependent on both the sensitivity and specificity of the diagnostic tools.Results: We propose a high-performance imaging platform based on silica-poly(ethylene glycol nanoparticles doped with rhodamine B and cyanine 5. Simultaneous detection of these dyes is the basis for background subtraction and signal amplification, thus providing high-sensitivity imaging. The functionalization of poly(ethylene glycol tails on the external face of the nanoparticles with metastasis-specific peptides guarantees their homing to and accumulation at target tissues, resulting in specific visualization, even of submillimetric metastases.Conclusions: The results reported here demonstrate that our rationally designed modular nanosystems have the ability to produce a breakthrough in the detection of micrometastases for subsequent translation to clinics in the immediate future.Keywords: colorectal cancer, imaging platform, luminescent targeting

Cariogram outcome after 90 days of oral treatment with Streptococcus salivarius M18 in children at high risk for dental caries: results of a randomized, controlled study

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Di Pierro F

2015-10-01

Full Text Available Francesco Di Pierro,1 Alberto Zanvit,2 Piero Nobili,2 Paolo Risso,3 Carlo Fornaini4 1Scientific Department, Velleja Research, 2Stomatology Institute, Milan, Italy; 3Department of Health Science, University of Genoa, Genoa, Italy; 4Teleo Laboratory, Faculty of Dentistry, University of Nice, Nice, France Abstract: Dental caries is the most common chronic disease of childhood. Cariogram is a well-recognized algorithm-based software program based on different caries-related risk factors and intended to aid clinicians in performing more objective and consistent dental caries risk assessments. This type of approach precedes the diagnosis of caries and allows the dentist to identify at-risk patients and then take appropriate preventive measures before caries develop further. One of the etiological factors favoring the development of dental caries is the mutans streptococci. These acidogenic dental plaque inhabitants can be effectively antagonized by the activity of bacteriocins released by the probiotic Streptococcus salivarius M18 (salivarius M18. Moreover, salivarius M18 after colonizing the human oral mucosa produces the enzymes dextranase and urease that are able to counteract plaque formation and saliva acidity, respectively. Seventy-six subjects at high risk of dental caries were randomized and then either treated or not treated for 90 days with an oral formulation containing the oral probiotic salivarius M18 (Carioblis®. The results indicate that the use of salivarius M18 increases the chances of avoiding new dental caries development in children, and its application could be proposed as a new tool in the dentist's armory to be adopted in subjects considered at high risk on the basis of their Cariogram outcome. Keywords: BLIS M18, caries prediction, dextranase, urease, Streptococcus mutans, Streptococcus sobrinus, plaque, salivary pH, bacteriocins

Nanopatterned acellular valve conduits drive the commitment of blood-derived multipotent cells

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Di Liddo R

2016-10-01

Full Text Available Rosa Di Liddo,1,2 Paola Aguiari,3 Silvia Barbon,1,2 Thomas Bertalot,1 Amit Mandoli,1 Alessia Tasso,1 Sandra Schrenk,1 Laura Iop,3 Alessandro Gandaglia,3 Pier Paolo Parnigotto,2 Maria Teresa Conconi,1,2 Gino Gerosa31Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 2Foundation for Biology and Regenerative Medicine, Tissue Engineering and Signaling ONLUS, 3Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy Abstract: Considerable progress has been made in recent years toward elucidating the correlation among nanoscale topography, mechanical properties, and biological behavior of cardiac valve substitutes. Porcine TriCol scaffolds are promising valve tissue engineering matrices with demonstrated self-repopulation potentiality. In order to define an in vitro model for investigating the influence of extracellular matrix signaling on the growth pattern of colonizing blood-derived cells, we cultured circulating multipotent cells (CMC on acellular aortic (AVL and pulmonary (PVL valve conduits prepared with TriCol method and under no-flow condition. Isolated by our group from Vietnamese pigs before heart valve prosthetic implantation, porcine CMC revealed high proliferative abilities, three-lineage differentiative potential, and distinct hematopoietic/endothelial and mesenchymal properties. Their interaction with valve extracellular matrix nanostructures boosted differential messenger RNA expression pattern and morphologic features on AVL compared to PVL, while promoting on both matrices the commitment to valvular and endothelial cell-like phenotypes. Based on their origin from peripheral blood, porcine CMC are hypothesized in vivo to exert a pivotal role to homeostatically replenish valve cells and contribute to hetero- or allograft colonization. Furthermore, due to their high responsivity to extracellular matrix nanostructure signaling, porcine CMC could be useful for a preliminary

Large-spot subthreshold transpupillary thermotherapy for chronic serous macular detachment

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Giuseppe Lo Giudice

2011-03-01

Full Text Available Giuseppe Lo Giudice1, Valentina de Belvis2, Marco Tavolato1, Alessandro Galan11San Paolo Ophthalmic Center, San Antonio Hospital, Padova, Italy; 2Paediatric Low Vision Center, Paediatric Rare Eye Disease Center, Department of Paediatrics, University of Padova, ItalyPurpose: To report the effect of subthreshold transpupillary thermotherapy (TTT in treating serous detachment of the neurosensory retina secondary to chronic central serous chorioretinopathy (CCSC.Methods: Seven eyes from five patients with CCSC, persistent serous detachment of the neurosensory retina and a clinical course of between 12 and 60 months were treated. All eyes received large-spot TTT guided by indocyanine green angiography (ICGA. Subthreshold TTT was performed using an 810 nm diode laser with a spot size of 3.0 mm (power was set at 350 mW. Treatment was applied for 60 seconds to the areas of choroidal hyperfluorescence on ICGA.Results: The mean number of TTT sessions was 1.4 ± 0.5. All eyes were followed up for at least 6 months (mean 9.6 ± 3.2 standard deviation; range 6–12 months. The mean logarithm of the minimum angle of resolution best-corrected visual acuity was significantly better compared with baseline. All TTT-treated eyes had stable or improved vision (P < 0.001. Mean optical coherence tomography (OCT central foveal thickness was significantly lower in all patients (P < 0.001 compared with pretreatment OCT, with a reduction in subretinal fluid and resolution of serous detachment associated with anatomical fovea restoration. No patient had any treatment-related side effects.Conclusion: Modified subthreshold TTT appears to have a beneficial effect in treating patients with CCSC and persistent neurosensory detachment. The encouraging results and lack of visually significant complications suggest that further investigation is warranted.Keywords: central serous chorioretinopathy, indocyanine green angiography, neurosensory detachment, transpupillary

Biocompatible nanocomposite for PET/MRI hybrid imaging

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Locatelli E

2012-12-01

Full Text Available Erica Locatelli,1 Larraitz Gil,2 Liron Limor Israel,3 Lorena Passoni,4,5 Maria Naddaka,1 Andrea Pucci,1 Torsten Reese,6 Vanessa Gomez-Vallejo,2 Paolo Milani,5,7 Michela Matteoli,4,8 Jordi Llop,2 Jean Paul Lellouche,3 Mauro Comes Franchini11Department of Industrial Chemistry “Toso Montanari”. University of Bologna, Italy; 2Radiochemistry Department, Molecular Imaging Unit, CIC biomaGUNE, San Sebastián, Guipúzcoa, Spain; 3Department of Chemistry, Nanomaterials Research Centre, Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel; 4Department of Medical Biotechnology and Translational Medicine, University of Milano, Italy; 5Fondazione Filarete, Milano, Italy; 6Imaging Department, Molecular Imaging Unit, CIC biomaGUNE, San Sebastián, Guipúzcoa, Spain; 7CIMAINA and Department of Physics, University of Milano, Italy; 8Humanitas Clinical and Research Center, Rozzano, ItalyAbstract: A novel nanocarrier system was designed and developed with key components uniquely structured at the nanoscale for early cancer diagnosis and treatment. In order to perform magnetic resonance imaging, hydrophilic superparamagnetic maghemite nanoparticles (NPs were synthesized and coated with a lipophilic organic ligand. Next, they were entrapped into polymeric NPs made of biodegradable poly(lactic-co-glycolic acid linked to polyethylene glycol. In addition, resulting NPs have been conjugated on their surface with a 2,2'-(7-(4-((2-aminoethylamino-1-carboxy-4-oxobutyl-1,4,7-triazonane-1,4-diyldiacetic acid ligand for subsequent 68Ga incorporation. A cell-based cytotoxicity assay has been employed to verify the in vitro cell viability of human pancreatic cancer cells exposed to this nanosystem. Finally, in vivo positron emission tomography-computerized tomography biodistribution studies in healthy animals were performed.Keywords: maghemite nanoparticles, organic coating, polymeric nanoparticles, magnetic resonance imaging

Conflits de civilisation et pulsion de mort. La Médée de Pasolini, un paradigme actuel

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Sonia Rovito

2017-01-01

Full Text Available Cette communication a pour objet la lecture textuelle du film Médée de Pier Paolo Pasolini. Elle fait référence au conflit entre une culture du sacré, du magique, du rituel, incarnée par Médée, et une culture du profane, du rationnel, de l’historique, représentée par Jason au cours de son héroïque et destructive entreprise de s’emparer de la Toison d’Or et de séduction de la femme. Avec un regard aux lectures d’anthropologie et de psychanalyse des archétypes et des mythes, effectuées par le réalisateur dans la période de préparation de son film, et grâce à sa rencontre avec le Traité des Religions de Mircea Eliade, on met en évidence les motivations les plus profondes de l'effet de déflagration d’un monde, le monde archaïque de la Colchide, mais aussi de celui des origines, dans lequel Jason fut élevé et éduqué. Ce monde a été soumis à la violence d’une hybris incapable à reconnaître le rapport avec les matrices inconscientes, mais en même temps structurées, d’une civilisation antécédente et plus puissante. En ce sens, la vengeance de Médée représente pour Pasolini la révélation désespérée et incoercible d’une lois violée qui, avec la force de son atroce revanche, interroge la mentalité des hommes modernes, lancés désormais vers un modèle de développement tout à fait nihiliste.

Isaac Newton: Eighteenth-century Perspectives

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Hall, A. Rupert

1999-05-01

This new product of the ever-flourishing Newton industry seems a bit far-fetched at first sight: who but a few specialists would be interested in the historiography of Newton biography in the eighteenth century? On closer inspection, this book by one of the most important Newton scholars of our day turns out to be of interest to a wider audience as well. It contains several biographical sketches of Newton, written in the decades after his death. The two most important ones are the Eloge by the French mathematician Bernard de Fontenelle and the Italian scholar Paolo Frisi's Elogio. The latter piece was hitherto unavailable in English translation. Both articles are well-written, interesting and sometimes even entertaining. They give us new insights into the way Newton was revered throughout Europe and how not even the slightest blemish on his personality or work could be tolerated. An example is the way in which Newton's famous controversy with Leibniz is treated: Newton is without hesitation presented as the wronged party. Hall has provided very useful historical introductions to the memoirs as well as footnotes where needed. Among the other articles discussed is a well-known memoir by John Conduitt, who was married to Newton's niece. This memoir, substantial parts of which are included in this volume, has been a major source of personal information for Newton biographers up to this day. In a concluding chapter, Hall gives a very interesting overview of the later history of Newton biography, in which he describes the gradual change from adoration to a more critical approach in Newton's various biographers. In short, this is a very useful addition to the existing biographical literature on Newton. A J Kox

Workflow in clinical trial sites & its association with near miss events for data quality: ethnographic, workflow & systems simulation.

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de Carvalho, Elias Cesar Araujo; Batilana, Adelia Portero; Claudino, Wederson; Reis, Luiz Fernando Lima; Schmerling, Rafael A; Shah, Jatin; Pietrobon, Ricardo

2012-01-01

With the exponential expansion of clinical trials conducted in (Brazil, Russia, India, and China) and VISTA (Vietnam, Indonesia, South Africa, Turkey, and Argentina) countries, corresponding gains in cost and enrolment efficiency quickly outpace the consonant metrics in traditional countries in North America and European Union. However, questions still remain regarding the quality of data being collected in these countries. We used ethnographic, mapping and computer simulation studies to identify/address areas of threat to near miss events for data quality in two cancer trial sites in Brazil. Two sites in Sao Paolo and Rio Janeiro were evaluated using ethnographic observations of workflow during subject enrolment and data collection. Emerging themes related to threats to near miss events for data quality were derived from observations. They were then transformed into workflows using UML-AD and modeled using System Dynamics. 139 tasks were observed and mapped through the ethnographic study. The UML-AD detected four major activities in the workflow evaluation of potential research subjects prior to signature of informed consent, visit to obtain subject́s informed consent, regular data collection sessions following study protocol and closure of study protocol for a given project. Field observations pointed to three major emerging themes: (a) lack of standardized process for data registration at source document, (b) multiplicity of data repositories and (c) scarcity of decision support systems at the point of research intervention. Simulation with policy model demonstrates a reduction of the rework problem. Patterns of threats to data quality at the two sites were similar to the threats reported in the literature for American sites. The clinical trial site managers need to reorganize staff workflow by using information technology more efficiently, establish new standard procedures and manage professionals to reduce near miss events and save time/cost. Clinical trial

Comparative pharmacokinetic and pharmacodynamic evaluation of branded and generic formulations of meloxicam in healthy male volunteers

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Del Tacca M

2013-07-01

Full Text Available Mario Del Tacca,1,2 Giuseppe Pasqualetti,3 Giovanni Gori,1 Pasquale Pepe,1 Antonello Di Paolo,2 Marianna Lastella,2 Ferdinando De Negri,1 Corrado Blandizzi2 1Clinical Pharmacology Centre for Drug Experimentation, Pisa University Hospital, 2Department of Clinical and Experimental Medicine, 3Geriatrics Unit, University of Pisa, Pisa, Italy Purpose: The primary aim of the present study was to assess the pharmacokinetic bioequivalence between a generic formulation of meloxicam 15 mg tablets (Meloxicam Hexal and its respective brand product (Mobic, in order to verify whether the generic product conforms to the regulatory standards of bioequivalence in the postmarketing setting. As a secondary exploratory aim, the pharmacodynamic effects of the two formulations were also evaluated by means of rating scales following hyperalgesia induced by cutaneous freeze injury. Subjects and methods: A single 15 mg dose of generic or branded meloxicam tablets was administered to 24 healthy male volunteers in a crossover fashion. Plasma samples, collected for 24 hours after dosing, were assayed for meloxicam concentration by a validated high-performance liquid chromatography method. Results: The analysis of pharmacokinetic parameters did not show any significant difference between the two meloxicam formulations: the 90% confidence intervals fell within the acceptance range of 80%–125% (0.84–1.16 for area under the curve [0–24], and 0.89–1.23 for peak concentration. No difference in the pharmacodynamic end point was observed between the two groups. Conclusion: The pharmacokinetic profiles of the two meloxicam formulations confirm the regulatory criteria for bioequivalence; pharmacodynamic data indicate a similar antihyperalgesic effect. The two formulations can be used interchangeably in the clinical setting. Keywords: meloxicam, pharmacokinetics, healthy volunteers, generic drug, bioequivalence, postmarketing

Primary care for opioid use disorder

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Mannelli P

2016-08-01

Full Text Available Paolo Mannelli,1 Li-Tzy Wu1–41Department of Psychiatry and Behavioral Sciences, 2Department of Medicine, 3Duke Clinical Research Institute, Duke University Medical Center, 4Center for Child and Family Policy, Sanford School of Public Policy, Duke University, Durham, NC, USARecent reports on prescription opioid misuse and abuse have described unprecedented peaks of a national crisis and the only answer is to expand prevention and treatment, including different levels of care.1 Nonetheless, concerns remain about the ability of busy primary care settings to manage problem opioid users along with other patients. In particular, proposed extensions of buprenorphine treatment, a critically effective intervention for opioid use disorder (OUD, are cautiously considered due to the potential risk of misuse or abuse.2 General practitioners are already facing this burden daily in the treatment of chronic pain, and expert supervision and treatment model adjustment are needed to help improve outcomes. Approximately 20% of patients in primary care have noncancer pain symptoms, with most of them receiving opioid prescriptions by their physicians, and their number is increasing.3 Pain diagnoses are comparable in severity to those of tertiary centers and are complicated by significant psychiatric comorbidity, with a measurable lifetime risk of developing OUD.4,5 Some primary care physicians report frustration about opioid abuse and diversion by their patients; support from pain specialists would improve their competence, the quality f their performance, and the ability to identify patients at risk of opioid misuse.6 Thus, buprenorphine treatment should not be adding to a complex clinical scenario. To this end, the promising models of care emphasize the integration of medical with psychological and pharmacological expertise for the management of OUD. 

K-Ca Dating of Alkali-Rich Fragments in the Y-74442 and Bhola LL-Chondritic Breccias

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Yokoyama, T; Misawa, K.; Okano, O; Shih, C. -Y.; Nyquist, L. E.; Simon, J. I.; Tappa, M. J.; Yoneda, S.

2013-01-01

Alkali-rich igneous fragments in the brecciated LL-chondrites, Krahenberg (LL5) [1], Bhola (LL3-6) [2], Siena (LL5) [3] and Yamato (Y)-74442 (LL4) [4-6], show characteristic fractionation patterns of alkali and alkaline elements [7]. The alkali-rich fragments in Krahenberg, Bhola and Y-74442 are very similar in mineralogy and petrography, suggesting that they could have come from related precursor materials [6]. Recently we reported Rb-Sr isotopic systematics of alkali-rich igneous rock fragments in Y-74442: nine fragments from Y-74442 yield the Rb-Sr age of 4429 plus or minus 54 Ma (2 sigma) for lambda(Rb-87) = 0.01402 Ga(exp -1) [8] with the initial ratio of Sr-87/Sr-86 = 0.7144 plus or minus 0.0094 (2 sigma) [9]. The Rb-Sr age of the alkali-rich fragments of Y-74442 is younger than the primary Rb-Sr age of 4541 plus or minus 14 Ma for LL-chondrite whole-rock samples [10], implying that they formed after accumulation of LL-chondrite parental bodies, although enrichment may have happened earlier. Marshall and DePaolo [11,12] demonstrated that the K-40 - Ca-40 decay system could be an important chronometer as well as a useful radiogenic tracer for studies of terrestrial rocks. Shih et al. [13,14] and more recently Simon et al. [15] determined K-Ca ages of lunar granitic rocks, and showed the application of the K-Ca chronometer for K-rich planetary materials. Since alkali-rich fragments in the LL-chondritic breccias are highly enriched in K, we can expect enhancements of radiogenic Ca-40. Here, we report preliminary results of K-Ca isotopic systematics of alkali-rich fragments in the LL-chondritic breccias, Y-74442 and Bhola.

Mimmo Paladino: every realization is imperfection

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Marta Gabriele

2015-12-01

Full Text Available The construction of a site-specific work made by Mimmo Paladino for the piazza Santa Croce in Florence in 2012 stands as an important testimony to a possible relationship between urban space and sacred symbols. The installation, commissioned by the International Biennal of Cultural and Landscape Heritage of Florence, is a monumental work: a giant cross made by arranging huge blocks of marble in front of the magnificent Franciscan cathedral of Florence. With this urban installation Mimmo Paladino faces once again the limit and the possibility of communication through symbols and images in contemporary art, exploring the vitality of figurative archetypes, including Christian ones. “The stones” - says the artist - “come from Carrara as they were dug out. Some will carry engravings and signs, others will become a sort of base for three metal sculptures: acircle and a star, that is two of the mazzocchi studied by Paolo Uccello, and an anthropomorphic stele that arises in dialogue with the statue of Dante. The passer-by cannot take in with a glance the form in its entirety: to discover it he will have to approach it and pass through it”. It’s an archaic work that changes the perception of the square: it suggests and requires new perspectives, it balances the space inviting the viewer to take action and to experience a new urban place, recreating a Renaissance cantiere. The symbol of the cross, in the artist’s poetic vision, is an ancient sign with an “orthodox” meaning. It’s the cross of Jesus, it’s an ancient and modern sign that rewrites and generates a new public space, like a square: a place of civil life.

Detecting Slow Deformation Signals Preceding Dynamic Failure: A New Strategy For The Mitigation Of Natural Hazards (SAFER)

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Vinciguerra, S.; Colombero, C.; Comina, C.; Umili, G.

2015-12-01

Rock slope monitoring is a major aim in territorial risk assessment and mitigation. The use of "site specific" microseismic monitoring systems can allow to detect pre-failure signals in unstable sectors within the rock mass and to predict the possible acceleration to the failure. To this aim multi-scale geophysical methods can provide a unique tool for an high-resolution imaging of the internal structure of the rock mass and constraints on the physical state of the medium. We present here a cross-hole seismic tomography survey coupled with laboratory ultrasonic velocity measurements and determination of physical properties on rock samples to characterize the damaged and potentially unstable granitic cliff of Madonna del Sasso (NW, Italy). Results allowed to achieve two main advances, in terms of obtaining: i) a lithological interpretation of the velocity field obtained at the site, ii) a systematic correlation of the measured velocities with physical properties (density and porosity) and macroscopic features of the granite (weathering and anisotropy) of the cliff. A microseismic monitoring system developed by the University of Turin/Compagnia San Paolo, consisting of a network of 4 triaxial geophones (4.5 Hz) connected to a 12-channel data logger, has been deployed on the unstable granitic cliff. More than 2000 events with different waveforms, duration and frequency content were recorded between November 2013 and July 2014. By inspecting the acquired events we identified the key parameters for a reliable distinction among the nature of each signal, i.e. the signal shape (in terms of amplitude, duration, kurtosis) and the frequency content (maximum frequency content and frequency distribution). Four main classes of recorded signals can be recognised: microseismic events, regional earthquakes, electrical noises and calibration signals, and unclassified events (probably grouping rockfalls, quarry blasts, other anthropic and natural sources of seismic noise).

Support management in schizophrenia: a systematic review of current literature

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Pompili M

2012-12-01

Full Text Available Maurizio Pompili,1 Franco Montebovi,1 Alberto Forte,1 Mario Palermo,1 Henry Stefani,1 Ludovica Telesforo,1 Sandra Campi,1 Gloria Giordano,1 Lucia Longo,1 Dorian A Lamis,2 Gianluca Serafini,1 Paolo Girardi11Department of Neurosciences, Mental Health and Sensory Functions, Suicide Prevention Center, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy; 2Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USABackground: Schizophrenia is generally considered a chronic disorder characterized by psychotic symptoms and relatively stable neurocognitive and interpersonal deficits. Antipsychotic medication has proven beneficial in reducing psychotic symptoms, but is often not enough to treat cognitive or functional impairments. Residual cognitive impairments are barriers to a patient’s full recovery from schizophrenia. Rehabilitation is an alternative and important approach which may be useful, and encompasses a variety of treatments including social skills training and psychoeducational and cognitive behavioral treatments.Objective: To investigate the efficacy of psychosocial treatments in schizophrenia, evaluating its effects in the short and long term, comparing psychosocial treatments with pharmacotherapy, and assessing the effects of treatment and the main indications for use in patients with schizophrenia.Methods: A careful MEDLINE®, Excerpta Medica, PsycLIT®, PsycINFO®, and Index Medicus search was performed to identify all papers and book chapters in English for the period 1970–2012.Results: Findings from the studies included in this qualitative analysis suggest that social skills therapy, cognitive behavioral therapy, family intervention therapy, cognitive remediation therapy, and other nonpharmacological therapeutic strategies may be beneficial for patients with significant functional and symptomatic impairments.Conclusion: Schizophrenic patients treated with nonpharmacological

Psychological well-being and Posttraumatic growth in caregivers of cancer patients

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Claudia eCormio

2014-11-01

Full Text Available IntroductionAlthough research has shown that many cancer patients report positive life changes following cancer diagnosis, there are few data in the literature related to PTG in caregivers of cancer patients. However, the few studies available have shown that this kind of positive changes can also be experienced by family members. The aims of this study were to explore PTG in caregivers of cancer patients and to investigate correlations between the Posttraumatic growth, psychological status and QoL of caregivers and those of patients, taking into account also clinical and socio-demographic aspects.Methods We enrolled 60 patient/caregiver pairs in the Department of Medical Oncology of the National Research Center ‘Giovanni Paolo II’ in Bari. Both patients and caregivers were assessed using the following scales: Posttraumatic growth Inventory (PTGI; Hospital anxiety and depression scale; Short Form (36 Health Survey (SF-36; ECOG Performance Status. Clinical and socio-demographic data were collected. ResultsCaregivers showed significantly higher scores than patients in the dimension of personal strength. Furthermore, we found a significantly close association between anxiety and depression of caregivers with those of patients. Younger caregivers were better than older ones in terms of physical activity, vitality, mental health, and social activities. Although the degree of relationship with the patient has no significant effect on the dependent variables of the study, it was found that caregivers with a degree of kinship more distant to the patient have less physical pain than the closest relatives.ConclusionResults of the present study show that caregivers of cancer patients may experience post-traumatic growth as the result of their caregiver role. It would be interesting to investigate in future research which factor may mediate the presence of post-traumatic growth.

Unlocking Ft: Modeling thermodynamic controls and isotope fractionation factors in nutrient limited environments

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Druhan, J. L.; Giannetta, M.; Sanford, R. A.

2017-12-01

, resulting in model behavior which is, in effect, a microbial redox analog to the variable observed fractionation factor resulting from a transition state theory rate law as derived by DePaolo (2011).

Astronomy in the Age of Leonardo.

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Welther, B. L.

1997-12-01

In the 1450s, when Leonardo da Vinci was born, horoscopes were still based primarily on the 13th-century tables developed in the court of Alfonso el Sabio of Spain. By the 15th century European astronomers were computing revised forms of the tables. In Italy, for example, Giovanni Bianchini of Ferrara completed his Tabulae astronomicae in the 1440s. It was finally published posthumously in Venice in 1495. By the 1480s Domenico Maria Novara, a professor of astronomy in Bologna, was publishing annual prognostications of eclipses, conjunctions, and other celestial phenomena. Against this background of traditional astronomy in Italy, two Florentines recorded observations of the sun and moon, comets, and meteorology. Paolo dal Pozzi Toscanelli flourished in the first half of the 15th century and Leonardo da Vinci in the last half. Their observations of celestial phenomena were not primarily for astronomical purposes; they were spinoffs of other pursuits such as medicine, astrology, optics, engineering, and studies of light and shadow. As a physician and cartographer, Toscanelli practiced astrology, studied omens, observed comets and plotted their paths on homemade maps. He also was associated with the construction of a gnomon at the top of the Duomo to observe the summer solstice. It was this project that may have brought him into contact with the young artisan, Leonardo da Vinci. As a painter, Leonardo's approach to science and engineering was to observe, sketch and analyze. His interest in light and shadow led him to notice how the earth, moon and planets all reflect sunlight. His extant manuscripts have geometric sketches for eclipses and for the phenomenon known as "old moon in new moon's arms." Unfortunately, because neither Toscanelli nor Leonardo published their observations, they made no impact on the history of astronomical thought or observation. Their contemporaries did not know or write about their work. Astronomers in the 16th century did not know about

Kiglapait Feldspar States 5 to Review

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Morse, S. A.

2017-12-01

The 1305 Ga Kiglapait Intrusion of coastal Labrador records the crystallization of troctolite through olivine gabbro to magnetite- and apatite-bearing rocks to monoclinic sanidine- mesoperthite-ferrosyenite below an inverted stratigraphy of a thin Upper Border Zone. The crystallization history was about 1 Ma. ¶The evolutionary history of Kiglapait feldspars in an 8.4 km thick magma chamber runs from plagioclase An70 at 5 kbar and 1250°C, cooling through to ferrosyenite with mesoperthite and two feldspars at 3 kbar and 1,000°C. The residual magma encountered the binodal solvus and finished crystallizing as an azeotrope with plagioclase (Or 21, An 15) and sanidine (Or 52, An 8) in liquid (Xor = 1/3; An 11). Cooling in the subsolidus brought the feldspars to compositions An15-Or 3, An0-Or 80-85 at 800-730°C. Metastable mesoperthite on the coherent solvus in various stages of late equilibration persists in the local assemblages. Arrested to complete feldspar symplectites suggest the local presence of a vapor phase. ¶Splits of the final Or-rich feldspar were found by mass spectrometry to have a dominant quantity of Rb and 87Sr/86Sr along with % amounts of Ba; in contrast, the plag fraction has very low Rb and 87Sr/86Sr. The estimated timing of the isotopic segregation was plausibly continuous with major-element fractionation or perhaps at the moment(s) of exsolution. ¶The cooling record of the solidified intrusion at 3 kbar is shown by 40Ar/39Ar data to have been rapid, reaching an ambient temperature near 240°C within the first 20 Ma, compared to the ambient country-rock temperature before intrusion of 350°C. The difference suggests a late uplift of the region after the Kiglapait magmatism. ¶Contributions from Y. Yu, T. Krogh, M. Hamilton, D. Lindsley, D. DePaolo, M. Jercinovic and S.R. Hart are especially acknowledged.

Targeted tumor imaging of anti-CD20-polymeric nanoparticles developed for the diagnosis of B-cell malignancies

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Capolla S

2015-06-01

Full Text Available Sara Capolla,1 Chiara Garrovo,2 Sonia Zorzet,1 Andrea Lorenzon,3 Enrico Rampazzo,4 Ruben Spretz,5 Gabriele Pozzato,6 Luis Núñez,7 Claudio Tripodo,8 Paolo Macor,1,9 Stefania Biffi2 1Department of Life Sciences, University of Trieste, 2Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, 3Animal Care Unit, Cluster in Biomedicine (CBM scrl, Trieste, Italy; 4Department of Chemistry “G. Ciamician”, University of Bologna, Bologna, Italy; 5LNK Chemsolutions LLC, Lincoln, NE, USA; 6Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy; 7Bio-Target, Inc., University of Chicago, Chicago, IL, USA; 8Department of Human Pathology, University of Palermo, Palermo, Italy; 9Callerio Foundation Onlus, Institutes of Biological Researches, Trieste, Italy Abstract: The expectations of nanoparticle (NP-based targeted drug delivery systems in cancer, when compared with convectional therapeutic methods, are greater efficacy and reduced drug side effects due to specific cellular-level interactions. However, there are conflicting literature reports on enhanced tumor accumulation of targeted NPs, which is essential for translating their applications as improved drug-delivery systems and contrast agents in cancer imaging. In this study, we characterized biodegradable NPs conjugated with an anti-CD20 antibody for in vivo imaging and drug delivery onto tumor cells. NPs’ binding specificity mediated by anti-CD20 antibody was evaluated on MEC1 cells and chronic lymphocytic leukemia patients’ cells. The whole-body distribution of untargeted NPs and anti-CD20 NPs were compared by time-domain optical imaging in a localized human/mouse model of B-cell malignancy. These studies provided evidence that NPs’ functionalization by an anti-CD20 antibody improves tumor pharmacokinetic profiles in vivo after systemic administration and increases in vivo imaging of tumor mass compared to non-targeted NPs. Together

Forecast model for the evaluation of economic resources employed in the health care of patients with HIV infection

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Sacchi P

2012-05-01

Full Text Available Paolo Sacchi1, Savino FA Patruno1, Raffaele Bruno1, Serena Maria Benedetta Cima1, Pietro Previtali2, Alessia Franchini2, Luca Nicolini3, Carla Rognoni4, Lucia Sacchi5, Riccardo Bellazzi4, Gaetano Filice11Divisione di Malattie Infettive e Tropicali - Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; 2Università degli Studi di Pavia – Facoltà di Economia, Pavia, Italy; 3Controllo di Gestione Fondazione IRCCS Policlinico San Matteo di Pavia, Pavia, Italy; 4Dipartimento di Informatica e Sistemistica, Universita' degli Studi di Pavia, Pavia, Italy; 5Department of Information Systems and Computing, Brunel University, London, UKBackground and aims: The total health care cost for human immunodeficiency virus (HIV patients has constantly grown in recent years. To date, there is no information about how this trend will behave over the next few years. The aim of the present study is to define a pharmacoeconomic model for the forecast of the costs of a group of chronically treated patients followed over the period 2004–2009.Methods: A pharmacoeconomics model was built to describe the probability of transition among different health states and to modify the therapy over time. A Markov model was applied to evaluate the temporal evolution of the average cost. The health care resources exploited during hospitalization were analyzed by using an “activity-based costing” method.Results: The Markov model showed that the mean total cost, after an initial increase, tended to remain stable. A total of 20 clinical records were examined. The average daily cost for each patient was EUR 484.42, with a cost for admission of EUR 6781.88.Conclusion: The treatment of HIV infection in compliance with the guidelines is also effective from the payer perspective, as it allows a good health condition to be maintained and reduces the need and the costs of hospitalizations.Keywords: health care cost, HIV, Markov model, activity-based costing

Active home-based cancer treatment

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Bordonaro S

2012-06-01

Full Text Available Sebastiano Bordonaro Fabio Raiti, Annamaria Di Mari, Calogera Lopiano, Fabrizio Romano, Vitalinda Pumo, Sebastiano Rametta Giuliano, Margherita Iacono, Eleonora Lanteri, Elena Puzzo, Sebastiano Spada, Paolo TralongoUOC Medical Oncology, RAO, ASP 8 Siracusa, ItalyBackground: Active home-based treatment represents a new model of health care. Chronic treatment requires continuous access to facilities that provide cancer care, with considerable effort, particularly economic, on the part of patients and caregivers. Oral chemotherapy could be limited as a consequence of poor compliance and adherence, especially by elderly patients.Methods: We selected 30 cancer patients referred to our department and treated with oral therapy (capecitabine, vinorelbine, imatinib, sunitinib, sorafenib, temozolomide, ibandronate. This pilot study of oral therapy in the patient’s home was undertaken by a doctor and two nurses with experience in clinical oncology. The instruments used were clinical diaries recording home visits, hospital visits, need for caregiver support, and a questionnaire specially developed by the European Organization for Research and Treatment of Cancer (EORTC, known as the QLQ-C30 version 2.0, concerning the acceptability of oral treatment from the patient’s perspective.Results: This program decreased the need to access cancer facilities by 98.1%, promoted better quality of life for patients, as reflected in increased EORTC QLQ-C30 scores over time, allowing for greater adherence to oral treatment as a result of control of drug administration outside the hospital. This model has allowed treatment of patients with difficult access to care (elderly, disabled or otherwise needed caregivers that in the project represent the majority (78% of these.Conclusions: This model of active home care improves quality of life and adherence with oral therapy, reduces the need to visit the hospital, and consequently decreases the number of lost hours of work on

Efficacy of intravitreal dexamethasone implant for prostaglandin-induced refractory pseudophakic cystoid macular edema: case report and review of the literature

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Sacchi M

2014-07-01

Full Text Available Matteo Sacchi, Edoardo Villani, Francesca Gilardoni, Paolo Nucci University Eye Clinic, San Giuseppe Hospital, University of Milan, Milan, Italy Background: Macular edema is a known complication even after uneventful cataract surgery. The chronic use of prostaglandin analogs is a risk factor for the development of pseudophakic cystoid macular edema (CME. Nonsteroidal anti-inflammatory drugs (NSAIDs are considered first-line therapy but refractory postsurgical CME represents a therapeutic challenge, as there is not an evidence-based treatment.Objective: To report the use of a single implant of intravitreal dexamethasone for tafluprost-associated pseudophakic CME refractory to NSAIDs and to sub-Tenon’s corticosteroid injections.Case report: A 64-year-old female with ocular hypertension treated with tafluprost experienced decreased vision (visual acuity 20/60 and metamorphopsia 2 months after uneventful cataract extraction. Spectral domain optical coherence tomography (SD-OCT revealed CME. After 1 month of topical and oral NSAIDs, CME was still evident on SD-OCT (visual acuity 20/50. Two sub-Tenon’s betamethasone injections were performed at a 2-week interval. As CME was still present, 2 months after the diagnosis of CME (visual acuity 20/40, the patient underwent a single dexamethasone intravitreal implant. One month later, macular appearance was normal, and visual acuity increased to 20/30. This result was maintained throughout the 6 months of follow-up.Conclusion: In this report, a single implant of intravitreal dexamethasone successfully treated pseudophakic CME associated with the use of prostaglandin analogs unresponsive to NSAIDs and sub-Tenon’s betamethasone. The results of this report need to be corroborated by powered, prospective, randomized trials. The need for repeated treatments as well as the retreatment interval in patients requiring more than a single injection are issues still needing further investigations. Keywords

Antonio Mollari fra Canova e Valadier / Antonio Mollari between Canova and Valadier

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Elisa Debenedetti

2014-04-01

Full Text Available Non è difficile inserire Antonio Mollari in un contesto europeo. Ad Antonio Canova lo lega una prima, importantissima lettera del 4 maggio 1807 nella quale, in seguito ad un invito trasmessogli dallo scultore, ma di cui è responsabile Filippo III Colonna, enumera tutte le sue opere; la seconda risale al 25 febbraio 1809. Dalla prima missiva si riescono a stabilire numerosi contatti con Giuseppe Valadier: a Corridonia (Collegiata dei Santi Pietro, Paolo e Donato; Ospedale e Chiesa di San Salvatore e a Macerata (Palazzo Conti già Ugolini. Tanto da giungere a considerare Mollari come il continuatore del Valadier nei cantieri marchigiani, dove la presenza del Maestro si manifesta come una sovrapposizione di motivi francesizzanti a soluzioni palladiane: componenti entrambe presenti nel Palazzo Tomassini a Corridonia, ricondotto al Maceratese. Fra l’altro le pagine di due Taccuini valadieriani, certo a lui note, si possono considerare a metà strada fra l’esercizio tipologico ed il modello. It’s not difficult to insert Antonio Mollari into a European context. A first very important letter, dated May 4th 1807, links him to Antonio Canova whereby, after inviting him, by wish of Phillip Colonna III , he then makes a list of all his works of art; the second is dated February 25th 1809. Various contacts with Giuseppe Valadier can be established from the first letter: in Corridonia (Saints Peter, Paul and Donato Collegiate church; St. Saviour’s Hospital and Church and in Macerata (Conti Palace ex Ugolini. So much so as to regard Mollari as Valadier’s continuator in the Marche construction sites, where the Maestro’s presence is expressed like a superimposition of Frenchified motives for Palladian solutions: both components being present in the Tomassini Palace in Corridonia, which can be traced back to Mollari. Moreover the pages of two Valdier Notebooks, which he must have known about, can be considered half way between a typological exercise

Usability Testing of the BRANCH Smartphone App Designed to Reduce Harmful Drinking in Young Adults.

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Milward, Joanna; Deluca, Paolo; Drummond, Colin; Watson, Rod; Dunne, Jacklyn; Kimergård, Andreas

2017-08-08

Electronic screening and brief intervention (eSBI) apps demonstrate potential to reduce harmful drinking. However, low user engagement rates with eSBI reduce overall effectiveness of interventions. As "Digital Natives," young adults have high expectations of app quality. Ensuring that the design, content, and functionality of an eSBI app are acceptable to young adults is an integral stage to the development process. The objective of this study was to identify usability barriers and enablers for an app, BRANCH, targeting harmful drinking in young adults. The BRANCH app contains a drinking diary, alcohol reduction goal setting functions, normative drinking feedback, and information on risks and advice for cutting down. The app includes a social feature personalized to motivate cutting down and to promote engagement with a point-based system for usage. Three focus groups were conducted with 20 users who had tested the app for 1 week. A detailed thematic analysis was undertaken. The first theme, "Functionality" referred to how users wanted an easy-to-use interface, with minimum required user-input. Poor functionality was considered a major usability barrier. The second theme, "Design" described how an aesthetic with minimum text, clearly distinguishable tabs and buttons and appealing infographics was integral to the level of usability. The final theme, "Content" described how participants wanted all aspects of the app to be automatically personalized to them, as well as providing them with opportunities to personalize the app themselves, with increased options for social connectivity. There are high demands for apps such as BRANCH that target skilled technology users including young adults. Key areas to optimize eSBI app development that emerged from testing BRANCH with representative users include high-quality functionality, appealing aesthetics, and improved personalization. ©Joanna Milward, Paolo Deluca, Colin Drummond, Rod Watson, Jacklyn Dunne, Andreas Kimerg

Spectral domain OCT versus time domain OCT in the evaluation of macular features related to wet age-related macular degeneration

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Isola V

2012-02-01

Full Text Available Luisa Pierro1, Elena Zampedri1, Paolo Milani2, Marco Gagliardi1, Vincenzo Isola2, Alfredo Pece21Department of Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milano, Italy, 2Fondazione Retina 3000, Milano, ItalyBackground: The aim of this study was to compare the agreement between spectral domain optical coherence tomography (SD OCT and time domain stratus OCT (TD OCT in evaluating macular morphology alterations in wet age-related macular degeneration (AMD.Methods: This retrospective study was performed on 77 eyes of 77 patients with primary or recurring subfoveal choroidal neovascularization secondary to AMD. All patients underwent OCT examination using Zeiss Stratus OCT 3 (Carl Zeiss Meditec Inc, Dublin, CA and Opko OTI Spectral SLO/OCT (Ophthalmic Technologies Inc, Toronto, Canada. In all radial line scans, the presence of intraretinal edema (IRE, serous pigment epithelium detachment (sPED, neurosensory serous retinal detachment (NSRD, epiretinal membrane (EM, inner limiting membrane thickening (ILMT, and hard exudates (HE were evaluated. The degree of matching was quantified by Kappa measure of agreement.Results: The percentage distribution of TD OCT findings versus SD OCT findings was: IRE 36.3% versus 77.9%, sPED 57.1% versus 85.7%, NSRD 38.9% versus 53.2%, EM 10.5% versus 26.3%, ILMT 3.8% versus 32.4%, and HE 6.4% versus 54.5%. The agreement was as follows: sPED: kappa value 0.15; NSRD: kappa value 0.61; IRE: kappa value 0.18; EM: kappa value 0.41; ILMT: kappa value 0.02; HE: kappa value 0.06.Conclusion: The agreement in the evaluation of macular lesions between the two techniques is poor and depends on the lesion considered. SD OCT allows better detection of the alterations typically related to choroidal neovascularization such as IRE, PED, ILM thickening, and HE. Consequently its use should be strongly considered in patients with wet AMD.Keywords: spectral domain, OCT, time domain, macular degeneration, AMD

Evidence for preferences of Italian patients for physician attire

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Sotgiu G

2012-04-01

Full Text Available Giovanni Sotgiu1, Paolo Nieddu2, Laura Mameli2, Enrico Sorrentino2, Pietro Pirina3, Alberto Porcu4, Stefano Madeddu1, Manuela Idini1, Maddalena Di Martino1, Giuseppe Delitala2, Ida Mura1, Maria Pina Dore21Epidemiology and Medical Statistics Unit, Department of Biomedical Sciences, 2Clinica Medica, 3Pneumologia, 4Chirurgia dell’Obesità, University of Sassari, Sassari, ItalyBackground: The relationship between patient and physician is a complex interaction that includes multiple factors. The objective of this study was to explore Italian patients’ preferences regarding physician appearance.Methods: A questionnaire was developed to survey patients in different medical and surgical settings; each subject was asked to choose one picture of either a male or female physician from a selection of different attires (professional, casual, surgical scrubs, trendy, and careless. Patients were also surveyed about issues such as the presence of a name tag, hair length, trousers on women, amount of makeup, presence of tattoos, and body piercing. Statistical analysis was performed using a Chi-square test.Results: A total of 765 questionnaires (534 completed from patients waiting for an internal medicine visit and 231 for other subspecialties were completed. The majority (45% of patients preferred the gastroenterologist to wear a surgical scrub with a white coat. For the other specialists, patients accepted either scrubs or formal dress under a white coat (P ≤ 0.05, with a name tag. Trendy attire was preferred by nine patients (1.1%. The entire sample judged it inappropriate for clinicians to have long hair, visible tattoos, body piercing, and, for women, to wear trousers and use excessive makeup.Conclusion: This is the first study conducted in Italy regarding physician attire. As in other Western countries, Italian patients favor physicians in professional attire with a white coat. Wearing professional dress is part of “etiquette based medicine” and

Seasonal changes in nasal cytology in mite-allergic patients

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Gelardi M

2014-03-01

Full Text Available Matteo Gelardi,1 Diego G Peroni,2 Cristoforo Incorvaia,3 Nicola Quaranta,1 Concetta De Luca,1 Salvatore Barberi,4 Ilaria Dell'Albani,5 Massimo Landi,6 Franco Frati,5 Olivier de Beaumont7 1Otolaryngology Unit, Department of Neuroscience and Sensory Organs, University of Bari, Bari, Italy; 2Department of Pediatrics, University of Verona, Verona, Italy; 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy; 4Department of Pediatrics, San Paolo Hospital, Milan, Italy; 5Medical and Scientific Department, Stallergenes, Milan, Italy; 6Department of Pediatrics, National Healthcare System, ASL TO1, Turin, Italy; 7Medical Affairs Department, Stallergenes, Antony, France Background: House dust mites (HDMs are a major cause of allergic rhinitis (AR and asthma worldwide. Recent studies suggested that the allergen load presents seasonal modifications, giving rise to seasonal variation in nasal inflammation and symptoms. The aim of this study was to evaluate by nasal cytology whether nasal inflammation in mite-allergic patients changes with the seasons of the year. Methods: The study included 16 patients (seven males and nine females, mean age 38.1 years with persistent AR caused by monosensitization to HDMs. Nasal cytology was performed in all patients once monthly for 1 year. Results: Nasal cytology showed that the cells most commonly detected in the nasal mucosa were neutrophils. During the period from October to April, a peak in the number of neutrophils and also the presence of significant numbers of eosinophils, mast cells, and lymphocytes/plasma cells were found, which shows the occurrence of more intense inflammation during these months. Conclusion: Nasal cytology provides useful data in detecting nasal inflammation and its association with the clinical stage of AR. The seasonal variations in nasal cytology are likely to be induced by the fluctuations in the HDM allergen that have been uncovered in recent investigations. Keywords: allergens

Short timescale photometric and polarimetric behavior of two BL Lacertae type objects

International Nuclear Information System (INIS)

Covino, S.; Baglio, M. C.; Foschini, L.; Sandrinelli, A.; Tavecchio, F.; Treves, A.; Zhang, H.; Barres de Almeida, U.; Bonnoli, G.; Boettcher, M.; Cecconi, M.; D'Ammando, F.; Fabrizio, L. di; Giarrusso, M.; Leone, F.; Lindfors, E.; Lorenzi, V.; Molinari, E.; Paiano, S.; Prandini, E.; Raiteri, C. M.; Stamerra, A.; Tagliaferri, G.

2015-01-01

Context. Blazars are astrophysical sources whose emission is dominated by non-thermal processes, typically interpreted as synchrotron and inverse Compton emission. Although the general picture is rather robust and consistent with observations, many aspects are still unexplored. Aims. Polarimetric monitoring can offer a wealth of information about the physical processes in blazars. Models with largely different physical ingredients can often provide almost indistinguishable predictions for the total flux, but usually are characterized by markedly different polarization properties. We explore, with a pilot study, the possibility to derive structural information about the emitting regions of blazars by means of a joint analysis of rapid variability of the total and polarized flux at optical wavelengths. Methods. Short timescale (from tens of seconds to a couple of minutes) optical linear polarimetry and photometry for two blazars, BL Lacertae and PKS 1424+240, was carried out with the PAOLO polarimeter at the 3.6 m Telescopio Nazionale Galileo. Several hours of almost continuous observations were obtained for both sources. Results. Our intense monitoring allowed us to draw strongly different scenarios for BL Lacertae and PKS 1424+240, with the former characterized by intense variability on time-scales from hours to a few minutes and the latter practically constant in total flux. Essentially the same behavior is observed for the polarized flux and the position angle. The variability time-scales turned out to be as short as a few minutes, although involving only a few percent variation of the flux. The polarization variability time-scale is generally consistent with the total flux variability. Total and polarized flux appear to be essentially uncorrelated. However, even during our relatively short monitoring, different regimes can be singled out. Conclusions. No simple scenario is able to satisfactorily model the very rich phenomenology exhibited in our data. As a

Molecular characterization of intestinal protozoa in two poor communities in the State of São Paulo, Brazil.

Science.gov (United States)

David, Érica Boarato; Guimarães, Semíramis; de Oliveira, Ana Paula; Goulart de Oliveira-Sequeira, Teresa Cristina; Nogueira Bittencourt, Gabriela; Moraes Nardi, Ana Rita; Martins Ribolla, Paulo Eduardo; Bueno Franco, Regina Maura; Branco, Nilson; Tosini, Fabio; Bella, Antonino; Pozio, Edoardo; Cacciò, Simone M

2015-02-15

Several species of protozoa cause acute or chronic gastroenteritis in humans, worldwide. The burden of disease is particularly high among children living in developing areas of the world, where transmission is favored by lower hygienic standards and scarce availability of safe water. However, asymptomatic infection and polyparasitism are also commonly observed in poor settings. Here, we investigated the prevalence of intestinal protozoa in two small fishing villages, Porto Said (PS) and Santa Maria da Serra (SM), situated along the river Tietê in the State of São Paolo, Brazil. The villages lack basic public infrastructure and services, such as roads, public water supply, electricity and public health services. Multiple fecal samples were collected from 88 individuals in PS and from 38 individuals in SM, who were asymptomatic at the time of sampling and had no recent history of diarrheal disease. To gain insights into potential transmission routes, 49 dog fecal samples (38 from PS and 11 from SM) and 28 river water samples were also collected. All samples were tested by microscopy and PCR was used to genotype Giardia duodenalis, Blastocystis sp., Dientamoeba fragilis and Cryptosporidium spp. By molecular methods, the most common human parasite was Blastocystis sp. (prevalence, 45% in PS and 71% in SM), followed by D. fragilis (13.6% in PS, and 18.4% in SM) and G. duodenalis (18.2% in PS and 7.9% in SM); Cryptosporidium spp. were not detected. Sequence analysis revealed large genetic variation among Blastocystis samples, with subtypes (STs) 1 and 3 being predominant, and with the notable absence of ST4. Among G. duodenalis samples, assemblages A and B were detected in humans, whereas assemblages A, C and D were found in dogs. Finally, all D. fragilis samples from humans were genotype 1. A single dog was found infected with Cryptosporidium canis. River water samples were negative for the investigated parasites. This study showed a high carriage of intestinal

Negatively charged silver nanoparticles with potent antibacterial activity and reduced toxicity for pharmaceutical preparations

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Salvioni L

2017-03-01

Full Text Available Lucia Salvioni,1 Elisabetta Galbiati,1 Veronica Collico,1 Giulia Alessio,1 Svetlana Avvakumova,1 Fabio Corsi,2,3 Paolo Tortora,1 Davide Prosperi,1 Miriam Colombo1 1Nanobiolab, Department of Biotechnology and Bioscience, University of Milano-Bicocca, 2Biological and Clinical Science Department, University of Milan, Milano, 3Surgery Department, Breast Unit, IRCCS S Maugeri Foundation, Pavia, Italy Background: The discovery of new solutions with antibacterial activity as efficient and safe alternatives to common preservatives (such as parabens and to combat emerging infections and drug-resistant bacterial pathogens is highly expected in cosmetics and pharmaceutics. Colloidal silver nanoparticles (NPs are attracting interest as novel effective antimicrobial agents for the prevention of several infectious diseases.Methods: Water-soluble, negatively charged silver nanoparticles (AgNPs were synthesized by reduction with citric and tannic acid and characterized by transmission electron microscopy, dynamic light scattering, zeta potential, differential centrifuge sedimentation, and ultraviolet–visible spectroscopy. AgNPs were tested with model Gram-negative and Gram-positive bacteria in comparison to two different kinds of commercially available AgNPs.Results: In this work, AgNPs with higher antibacterial activity compared to the commercially available colloidal silver solutions were prepared and investigated. Bacteria were plated and the antibacterial activity was tested at the same concentration of silver ions in all samples. The AgNPs did not show any significant reduction in the antibacterial activity for an acceptable time period. In addition, AgNPs were transferred to organic phase and retained their antibacterial efficacy in both aqueous and nonaqueous media and exhibited no toxicity in eukaryotic cells.Conclusion: We developed AgNPs with a 20 nm diameter and negative zeta potential with powerful antibacterial activity and low toxicity compared

Nanoparticle-based strategy for personalized B-cell lymphoma therapy

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Martucci NM

2016-11-01

Full Text Available Nicola M Martucci,1,* Nunzia Migliaccio,1,* Immacolata Ruggiero,1,* Francesco Albano,2 Gaetano Calì,3 Simona Romano,1 Monica Terracciano,4 Ilaria Rea,4 Paolo Arcari,1 Annalisa Lamberti1 1Department of Molecular Medicine and Medical Biotechnology, University Federico II of Naples, Naples, 2Department of Experimental and Clinical Medicine, University of Catanzaro “Magna Graecia”, Catanzaro, 3Institute of Endocrinology and Molecular Oncology, 4Institute for Microelectronics and Microsystems, National Research Council, Naples, Italy *These authors contributed equally to this work Abstract: B-cell lymphoma is associated with incomplete response to treatment, and the development of effective strategies targeting this disease remains challenging. A new personalized B-cell lymphoma therapy, based on a site-specific receptor-mediated drug delivery system, was developed in this study. Specifically, natural silica-based nanoparticles (diatomite were modified to actively target the antiapoptotic factor B-cell lymphoma/leukemia 2 (Bcl2 with small interfering RNA (siRNA. An idiotype-specific peptide (Id-peptide specifically recognized by the hypervariable region of surface immunoglobulin B-cell receptor was exploited as a homing device to ensure specific targeting of lymphoma cells. Specific nanoparticle uptake, driven by the Id-peptide, was evaluated by flow cytometry and confocal microscopy and was increased by approximately threefold in target cells compared with nonspecific myeloma cells and when a random control peptide was used instead of Id-peptide. The specific internalization efficiency was increased by fourfold when siRNA was also added to the modified nanoparticles. The modified diatomite particles were not cytotoxic and their effectiveness in downregulation of gene expression was explored using siRNA targeting Bcl2 and evaluated by quantitative real-time polymerase chain reaction and Western blot analyses. The resulting gene silencing

Antonio Maria Baggio (ed., Adriana Cossedu, Paolo Giusta, Rodrigo Mardones Z. y Antonio Márquez Prieto, Caino e i suoi fratelli. Il fondamento relazionale nella politica e nel diritto, Città Nuova, Roma, 2012, 247 págs.

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María Salas Porras

2013-03-01

Full Text Available Los estudios recogidos en este volumen intentan reinterpretar los fundamentos de la Política y del Derecho, enmarcados en el horizonte relacional que la fraternidad les abre. Desde esta perspectiva, la fraternidad asume una relevancia política y jurídica en la medida en que se la entienda sustancialmente ligada a la libertad y a la igualdad. Cada una de las tres categorías, en la medida en que sean consideradas conjuntamente, llegan a adquirir su propio significado a través de la relación con las otras. El redescubrimiento de la fraternidad significa por tanto volver a proponer el "tríptico" entero, para recuperar, a través del mismo, el proyecto humanísitico de la modernidad, y liberarnos del destino del conflicto radical al que nuestro tiempo parece condenado: Caín no sólo ha matado a su hermano, sino que también ha fundado la primera ciudad, es decir, el lugar donde la violencia se ve confinada por el gobierno y por las leyes. Abrir el Derecho al horizonte de la fraternidad significa, hoy, llevar la racionalidad jurídica más allá de la mera racionalidad técnica; permitir renovar la relación jurídica, volver a encontrar sus fundamentos humanísticos, redescubriendo una justicia que reconcilia y reconstruye, fortificando el vínculo social. Considerar la fraternidad una categoría política significa poder emitir juicios políticos, capaces de producir un pensamiento político a través de la óptica de la fraternidad; se abandonan así las lógicas de la ideología, para intentar construir una forma de pensamiento en disposición de pasar, de una idea intuitiva de fraternidad, a una definición que la haga operativa, "operacionalizable". Es una tarea que no corresponde hoy a una sola disciplina, sino que interesa a todo el conjunto de los ya numerosos estudiosos que se han enrolado en este frente, interactuando entre sí de manera interdisiciplinar y abriendo un camino en el cual resulte posible, a todos los que han abrazado un humanismo y un ideal político, encontrar las mejores razones de su esperanza.

Antonio Maria Baggio (ed.), Adriana Cossedu, Paolo Giusta, Rodrigo Mardones Z. y Antonio Márquez Prieto, Caino e i suoi fratelli. Il fondamento relazionale nella politica e nel diritto, Città Nuova, Roma, 2012, 247 págs.

OpenAIRE

María Salas Porras

2013-01-01

Los estudios recogidos en este volumen intentan reinterpretar los fundamentos de la Política y del Derecho, enmarcados en el horizonte relacional que la fraternidad les abre. Desde esta perspectiva, la fraternidad asume una relevancia política y jurídica en la medida en que se la entienda sustancialmente ligada a la libertad y a la igualdad. Cada una de las tres categorías, en la medida en que sean consideradas conjuntamente, llegan a adquirir su propio significado a través de la relación con...

Design and Infrastructure: the Transformations of Senigallia’s Interface among Town, Port and Canal Progetto e infrastruttura: le trasformazioni dell’interfaccia città-porto-canale a Senigallia

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Antonella Falzetti

2009-11-01

Full Text Available  Senigallia is one of the several average-sized coast towns that, in the last decade, paid attention to redesign and reorganize their interface spaces between urban contexts and seafront activities. It is an attempt to re-establish a continuity between the urban fabric, the functional areas along the coastline, and the infrastructural system. Today, Senigallia’s morphological scenery shows a mixed seafront border line, whose characters have been alternatively determined by defense and protection needs, and, more recently, by trading and commercial functions. The town is crossed by the Misa river, a major linear infrastructure, which imposes its unfathomable laws of floods and flows, while claims some instruments for water control; the town is also dramatically split by the railway line, whose disruptive and excluding presence affects Senigallia and a great part of the Adriatic coast. In such terms, urban design, as a field of experimentation, is a powerful technical instrument, together with an appropriate management and control of urban policies, to elaborate operative proposals for sewing up the fracture – apparently incurable –, caused by the functional alienation of river banks, the decay of wildly urbanized coasts, and a poor integration of infrastructures into the urban dynamics. Several design experimentations have already been made in such direction; this is a proof of an important change in design trends, which could be applied to Senigallia’s situation too, in the frame of a vast program of urban refurbishment, promoted by the Municipality. Two noticeable interventions of this kind are: the enlargement and technical/functional upgrading of the port, and the project of a new tourist and residential district, designed by Paolo Portoghesi, to be built in ‘Sacelit/ex Italcementi’ area, one of the many in-between areas, dismissed and left for a long time abandoned, as a memory of a bygone productive season. In all these

Cream Soda. The rhythm of everyday life

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Eleonora Benecchi

2011-03-01

Full Text Available In this work I will focus my attention on a specific manga, Cream Soda by Adachi Mitsuru (1996. As suggested by Eco (1999, I will analyze this single work keeping in mind that it belongs to a medium and some genre practiced through this medium, but focusing my attention on the specific syntax of the speech of Adachi. This means that in this work I won’t talk about manga in general or in itself, at least, not in the foreground and in the first instance, but I will consider Adachi’s specific execution of the art of manga. This work will start from the analysis of single panels, and their relationship with each other inside the page layout, following the critical path indicated by Thierry Groensteen (1999, and will be then accompanied by the analysis of images and texts contained inside those panels, with special regard to their relationship with each other and with images and texts contained in other panels, following the lead of Barbieri (1995 and Pellitteri (1998.

The analysis of the elements that this text brings together to create a coherent narrative, and those elements it will not, will show that to properly understand Adachi’s manga the reader must recognize the fictional nature of what he is reading and his function as co-author of the story. Obviously this reflection is based on a first level or narrative interpretation of the text because it is starting from this basic layer that all the other layers can be explored. This is also the reason why this work provides a punctual examination of the single panels.

The analysis here proposed will also demonstrate that, despite many panels open up to different levels of readings, the activation of the second or third level of reading is not a given. It will also become evident, though, that if one stops at a first level reading, the most obvious one, the text in question isn’t really fulfilled according to its author’s expectations: the reader’s high engagement

Multimodal imaging and diagnosis of myopic choroidal neovascularization in Caucasians

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Milani P

2016-09-01

Full Text Available Paolo Milani,1 Amedeo Massacesi,1 Stefania Moschini,1 Marco Setaccioli,1 Ennio Bulone,1 Gemma Tremolada,1 Stefano Ciaccia,1 Elena Mantovani,1 Daniela Morale,2 Fulvio Bergamini1 1Ophthalmology Department, Istituto Auxologico, 2Institute of Mathematics, Universita’ degli Studi di Milano, Milan, Italy Purpose: To investigate myopic choroidal neovascularization (mCNV by fluorescein angio­graphy (FA, spectral-domain optical coherence tomography (SD-OCT, near-infrared (NIR reflectance, and autofluorescence (AF. Methods: This retrospective study included 65 eyes of 62 Caucasian patients with a mean age of 66.72 years (95% confidence interval [CI] 63–70 years and a mean refraction of -9.72 diopters (95% CI -8.74 to -10.70 diopters. Results: Most of the mCNV cases were foveal-juxtafoveal (60/65, 92.3%, with thickening of the corresponding retina (62/65, 95.3% and leakage on FA (44/65, 67.6%. No retinal fluid was detectable in 32 (49.2% eyes and there was no hemorrhage in 25 (38.4% eyes. Papillary chorio­retinal atrophy was evident in 58 (89.2%, a shadowing effect in 48 (73.8%, and an epiretinal membrane in 38 (58.4% eyes. If an area of macular chorioretinal atrophy was present, mCNV frequently developed adjacent to it and was hyperfluorescent rather than with leakage (P<0.001. In eyes with edema or hemorrhage, hyper-reflective foci were more frequent (P<0.005. NIR and AF features were indeterminable in 19 (29.2% and 27 (41.5% eyes, respectively. The predominant feature was black or grayish on NIR (34/65, 52.3% and patchy (hypo- and hyperfluorescence was observed on AF (25/65, 38.4%. FA and SD-OCT correctly detected mCNV in 49 (75.3% and 48 (73.8% eyes, respectively, whereas NIR and AF exhibited limited diagnostic sensitivity. Doubtful diagnosis was associated with hyperfluorescent mCNV (P<0.001, absence of retinal fluid and epiretinal membrane (P<0.05, and presence of macular chorioretinal atrophy (P<0.01. Conclusion: Tomographic, angiographic, AF

Fat-free mass change after nutritional rehabilitation in weight losing COPD: role of insulin, C-reactive protein and tissue hypoxia

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Simonetta Baldi

2010-02-01

Full Text Available Simonetta Baldi, Roberto Aquilani, Gian Domenico Pinna, Paolo Poggi, Angelo De Martini, Claudio BruschiDepartment of Pneumology and Biomedical Engineering, Scientific Institute of Montescano, Salvatore Maugeri Foundation I.R.C.C.S. Pavia, ItalyBackground: Fat-free mass (FFM depletion marks the imbalance between tissue protein synthesis and breakdown in chronic obstructive pulmonary disease (COPD. To date, the role of essential amino acid supplementation (EAAs in FFM repletion has not been fully acknowledged. A pilot study was undertaken in patients attending pulmonary rehabilitation.Methods: 28 COPD patients with dynamic weight loss > 5% over the last 6 months were randomized to receive EAAs embedded in a 12-week rehabilitation program (EAAs group n = 14, or to the same program without supplementation (C group n = 14. Primary outcome measures were changes in body weight and FFM, using dual X-ray absorptiometry (DEXA.Results: At the 12th week, a body weight increment occurred in 92% and 15% of patients in the EAAs and C group, respectively, with an average increase of 3.8 ± 2.6 kg (P = 0.0002 and −0.1 ± 1.1 kg (P = 0.81, respectively. A FFM increment occurred in 69% and 15% of EAAs and C patients, respectively, with an average increase of 1.5 ± 2.6 kg (P = 0.05 and −0.1 ± 2.3 kg (P = 0.94, respectively. In the EAAs group, FFM change was significantly related to fasting insulin (r2 0.68, P < 0.0005, C-reactive protein (C-RP (r2 = 0.46, P < 0.01, and oxygen extraction tension (PaO2x (r2 = 0.46, P < 0.01 at end of treatment. These three variables were highly correlated in both groups (r > 0.7, P < 0.005 in all tests.Conclusions: Changes in FFM promoted by EAAs are related to cellular energy and tissue oxygen availability in depleted COPD. Insulin, C-RP, and PaO2x must be regarded as clinical markers of an amino acid-stimulated signaling to FFM accretion.Keywords: COPD, pulmonary rehabilitation, branched chain amino acids, insulin, systemic

ESA Press Event: See Mars Express before its departure to the Red Planet

Science.gov (United States)

2002-08-01

There will be ten participants: four ESA astronauts (Pedro Duque, Leopold Eyharts, Paolo Nespoli and Thomas Reiter), four Japanese astronauts from NASDA (Takao Doi, Koichi Wakata, Satoshi Furukawa and Aikihido Hoshide) and two NASA astronauts (Nicole Passonno Stott and Stephanie D. Wilson). The main objective of this training session is to prepare the astronauts for the tasks they will have to perform when the Japanese experiment module (JEM) and ESA's Columbus laboratory are docked with the core of the International Space Station over the years ahead. After completing their training and certification, the astronauts will be assigned to long-duration missions to the ISS. The advanced training at the EAC will focus on the Columbus systems and the Automated Transfer Vehicle (ATV). It will consist of 24 classroom lectures on the Columbus and ATV systems and 4 on payloads, and 2 sessions in the Columbus Trainer. Instructors are being provided by Astrium for the Columbus systems and Alenia Spazio for the ATV, with ESA/EAC staff as mentors for the Columbus payloads. The astronauts are scheduled to visit Astrium in Bremen on 30 August to get acquainted with the flight unit of the Columbus laboratory module currently undergoing integration. This group of astronauts started their advanced training in April 2001 at NASA's Johnson Space Center (JSC), Houston, where they attended a first course on the US segment of the International Space Station. This was followed by training on the JEM system at NASDA's Tsukuba Space Center, Japan, in December 2001 - January 2002 and additional training at the JSC in May 2002. At the beginning of next year the group will be returning to Tsukuba for training on Japanese payloads. Hands-on sessions on Columbus Payload Training Models are scheduled for the second half of 2003, again at ESA's European Astronaut Centre. On Thursday 5 September, between 16:30 and 18:30 hrs, the astronauts and other ESA specialists will be available for interviews

The 40Ar/39Ar dating of core recovered by the Hawaii Scientific Drilling Project (phase 2), Hilo, Hawaii

Science.gov (United States)

Sharp, Warren D.; Renne, Paul R.

2005-04-01

The Hawaii Scientific Drilling Project, phase 2 (HSDP-2), recovered core from a ˜3.1-km-thick section through the eastern flanks of Mauna Loa and Mauna Kea volcanoes. We report results of 40Ar/39Ar incremental heating by broad-beam infrared laser of 16 basaltic groundmass samples and 1 plagioclase separate, mostly from K-poor tholeiites. The tholeiites generally have mean radiogenic 40Ar enrichments of 1-3%, and some contain excess 40Ar; however, isochron ages of glass-poor samples preserve stratigraphic order in all cases. A 246-m-thick sequence of Mauna Loa tholeiitic lavas yields an isochron age of 122 ± 86 kyr (all errors 2σ) at its base. Beneath the Mauna Loa overlap sequence lie Mauna Kea's postshield and shield sequences. A postshield alkalic lava yields an age of 236 ± 16 kyr, in agreement with an age of 240 ± 14 kyr for a geochemically correlative flow in the nearby HSDP-1 core hole, where more complete dating of the postshield sequence shows it to have accumulated at 0.9 ± 0.4 m/kyr, from about 330 to <200 ka. Mauna Kea's shield consists of subaerial tholeiitic flows to a depth of 1079 m below sea level, then shallow submarine flows, hyaloclastites, pillow lavas, and minor intrusions to core bottom at 3098 m. Most subaerial tholeiitic flows fail to form isochrons; however, a sample at 984 m yields an age of 370 ± 180 kyr, consistent with ages from similar levels in HSDP-1. Submarine tholeiites including shallow marine vitrophyres, clasts from hyaloclastites, and pillow lavas were analyzed; however, only pillow lava cores from 2243, 2614, and 2789 m yield reliable ages of 482 ± 67, 560 ± 150, and 683 ± 82 kyr, respectively. A linear fit to ages for shield samples defines a mean accumulation rate of 8.6 ± 3.1 m/kyr and extrapolates to ˜635 kyr at core bottom. Alternatively, a model relating Mauna Kea's growth to transport across the Hawaiian hot spot that predicts downward accelerating accumulation rates that reach ˜20 m/kyr at core bottom (DePaolo

The utility of pharmacogenetic testing to support the treatment of bipolar disorder

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Ielmini M

2018-03-01

Full Text Available Marta Ielmini,1 Nicola Poloni,1 Ivano Caselli,1 Jordi Espadaler,2 Miquel Tuson,2 Alessandro Grecchi,3 Camilla Callegari1 1Department of Medicine and Surgery, Division of Psychiatry, University of Insubria, Varese, Italy; 2AB-BIOTICS S.A, R&D Unit, Sant Cugat del Valles, Barcelona, Spain; 3ASST Santi Paolo e Carlo Borromeo, Division of Psychiatry, Milan, Italy Background: Bipolar disorder (BD is a frequent cause of disability, health care costs, and risk of suicide. Pharmacogenetic tests (PGTs could help clinicians to identify those patients predisposed to the occurrence of adverse events (AEs improving the understanding of the correlation between genetic variants and drug response.Materials and methods: The study evaluated 30 patients affected by BD type I or II (according to Diagnostic and Statistical Manual of Mental Disorders, version 5 who underwent the PGT Neurofarmagen® (AB-BIOTICS SA, Barcelona, Spain between March 2016 and March 2017. The primary aim of this study was to identify if the treatment prescribed by the psychiatrists was consistent with the treatment suggested by the PGT at T0 (corresponding to the test report communication. As a secondary aim, we wanted to assess if clinicians had changed the treatment (in case of discordance at T1 (3-month follow-up visit according to the results of the PGT.Results: At T0, only 4 patients (13% had an optimal therapy in line with the PGT suggestions. At 3-month follow-up, 13 patients (40% had received a change of therapy consistent to the test, showing a significant statistical improvement in the Clinical Global Impression item Severity (CGI-S score over time compared to those not having changes consistent with the test. Regarding AEs, at baseline 9 out of 10 (90% of the patients who received a therapy modification according to the test presented AEs, and a significant within-group reduction was observed after 3 months (p = 0.031.Conclusion: Despite the small sample size, the study shows

The effects of presenting oncologic information in terms of opposites in a medical context

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Burro R

2018-03-01

Full Text Available Roberto Burro,1 Ugo Savardi,1 Maria Antonietta Annunziata,2 Paolo De Paoli,2 Ivana Bianchi3 1Department of Human Sciences, University of Verona, Verona, Italy; 2National Cancer Institute IRCCS ‘Centro di Riferimento Oncologico’ (CRO, Aviano, Italy; 3Department of Humanities (Section Philosophy and Human Sciences, University of Macerata, Macerata, Italy Background: An extensive body of literature has demonstrated that many patients who have been asked to participate in clinical trials do not fully understand the informed consent forms. A parallel independent study has demonstrated that opposites have a special status in human cognitive organization: they are common to all-natural languages and are intuitively and naturally understood and learnt.Purpose: The study investigates whether, and how, the use of opposites impacts on doctor–patient communication: does using the terms “small–large” to describe a nodule (ie, bipolar communication rather than speaking in terms of centimeters (ie, unipolar communication affect a patient’s understanding of the situation? And is it better to speak of “common–rare” side effects (ie, bipolar communication instead of the number of people who have suffered from particular side effects (ie, unipolar communication?Methods: Two questionnaires were created and used, one presenting the information in terms of opposites (ie, bipolar communication and another using unipolar communication.Results: The participants’ perception of their situation (in terms of feeling healthy–ill, being at high–low risk, and their treatment requiring high–low commitment varied in the two conditions. Moreover, self-reported levels of understanding and satisfaction with how the information was communicated were higher when opposites were used.Limitations: Since this is the first study that addresses the merits of using bipolar structures versus unipolar structures in doctor–patient communication, further work is

The development of pain medicine in Italy and the rest of Europe 40 years after the first International Association for the Study of Pain Congress.

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Varrassi, Giustino; Paladini, Antonella

2017-01-01

Professor Giustino Varrassi and Antonella Paladini speak to Jade Parker, Commissioning Editor: Professor Giustino Varrassi is Full Professor of Anesthesiology and Pain Medicine in the LUdeS University, Valletta, Malta. He graduated at the Medical School of the University 'La Sapienza' (Rome, Italy) in 1973, and became board certified in Anesthesiology and Intensive Care in 1976 and in Pneumology in 1978, both in the same Medical School. He is currently President of the European League Against Pain and of the Paolo Procacci Foundation, and is a founding member of both of these. He is also a member of the World Institute of Pain, and a member of the Board of the Associazione Italiana per lo Studio del Dolore. He has been an invited speaker at more than 500 congresses (national and international), mainly in obstetric anesthesia and pain medicine. He is also the author of approximately 500 papers, published in international and national scientific journals, and 46 book chapters, mainly on obstetric anesthesia and pain medicine. He is the editor of 31 books and congress proceedings, including a textbook on obstetric anesthesia. He has also been the organizer of around 40 congresses, including European and World congresses on Pain Medicine. Professor Antonella Paladini is an Assistant Professor of Anesthesiology and Pain Medicine at the L'Aquila University, Italy. She has recently been nominated as Associate Professor of Anesthesiology in the LUdeS University, in Valletta, Malta. She graduated in medicine at L'Aquila University in 1989, and has got her Board Certification with laude in Anesthesia in 1992 and served as anesthetist in few teaching hospitals, mainly in cardiac surgery departments. Since 2000, she is in charge of the L'Aquila University, and has addressed her interests toward pain medicine. In 2004, she got the Board Certificate in Pain Medicine, with laude, in the University of Verona. She has a huge scientific production, with over 60 papers published in

Is increasing industrialization affecting remote ecosystem health in the South Americas? Insights from ocean surface water measurements of As, Sb and Pb from a GEOTRACES transect

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Weiss, Dominik; Salaun, Pascal; Van den Berg, Stan; Bi, Zaoshun

2014-05-01

Continued industrial development of the South Americas with increasing atmospheric emission of toxic trace metals has lead to a growing concern about possible effects on pristine ecosystem health. Concentration measurements of trace metals in ocean surface waters in the North Atlantic have successfully revealed the global extent of atmospheric pollution in the Northern Hemisphere during economical growth in the USA and Europe, suggesting a similar approach can be applied to the Southern Hemisphere. To this end, we determined concentrations of lead (Pb), antimony (Sb) and arsenic (As) using voltammetry in surface water samples of the South Atlantic Ocean collected during the third leg of the GEOTRACES West Atlantic Cruise. These elements are volatile and therefore most likely suitable tracer elements of industrial emissions from South America. The samples were not filtered and the solutions were acidified and UV digested. Total concentrations of Pb were detected. Detected As levels correspond to the sum of inorganic species (AsIII + AsV) plus the mono methyl arsenic acid (MMA) while the dimethyl arsenic acid (DMA) is not detected in such conditions. For Sb, detected levels correspond at least to the sum of inorganic fractions (SbIII + SbV). The measured concentrations for Pb varied from 6 to 23 pM. Concentrations were highest at -35° latitude and lowest at -40° and -50° latitude. We found a decreasing trend from about -35° latitude southwards. The average concentrations of As was 20 nM and of Sb 1.2 nM. Arsenic showed a more significant north to south trend than Sb. Arsenic concentration was highest at -23 ° latitude (21 nM) and the lowest at -43 ° latitude (17.7 nM). Antimony concentration was highest at -31 ° latitude (1.5 nM) and lowest at -35 ° latitude (1.0 nM). Our preliminary data suggests that the major industrial centres in Brazil (i.e., Sao Paolo, Rio de Janeiro) and Argentina (i.e., Buenos Aires) affect atmospheric metal fluxes to remote

PREFACE: 12th High-Tech Plasma Processes Conference (HTPP-12)

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Gleizes, Alain; Ghedini, Emanuele; Gherardi, Matteo; Sanibondi, Paolo; Dilecce, Giorgio

2012-12-01

organizing committee, the organizing secretariat and the financial support from the conference sponsors that allowed the success of HTPP-12. The Editors of the HTPP 12 Proceedings Professor Alain Gleizes (head of the ISC) Dr Emanuele Ghedini Dr Matteo Gherardi Dr Paolo Sanibondi Dr Giorgio Dilecce Bologna, 30 October 2012

Probing the mechanical properties of TNF-α stimulated endothelial cell with atomic force microscopy

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Sei-Young Lee

2011-01-01

Full Text Available Sei-Young Lee1,2, Ana-Maria Zaske3, Tommaso Novellino1,4*, Delia Danila3, Mauro Ferrari1,5*, Jodie Conyers3, Paolo Decuzzi1,6*1Department of Nanomedicine and Biomedical Engineering, The University of Texas Medical School at Houston, Houston, TX, USA; 2Department of Mechanical Engineering, The University of Texas at Austin, Austin, TX, USA; 3CeTIR – Center for Translational Injury Research, The University of Texas Health Science Center at Houston, Houston, TX, USA; 4Department of Biomedical Engineering, Biomedical Campus University of Rome, Italy; 5MD Anderson Cancer Center, Houston, TX, USA; 6BioNEM – Center of Bio-Nanotechnology and Engineering for Medicine, University of Magna Graecia, Catanzaro, Italy; *Currently at Department of Nanomedicine and Biomedical Engineering, The Methodist Hospital Research Institute, Houston, TX, USAAbstract: TNF-α (tumor necrosis factor-α is a potent pro-inflammatory cytokine that regulates the permeability of blood and lymphatic vessels. The plasma concentration of TNF-α is elevated (> 1 pg/mL in several pathologies, including rheumatoid arthritis, atherosclerosis, cancer, pre-eclampsia; in obese individuals; and in trauma patients. To test whether circulating TNF-α could induce similar alterations in different districts along the vascular system, three endothelial cell lines, namely HUVEC, HPMEC, and HCAEC, were characterized in terms of 1 mechanical properties, employing atomic force microscopy; 2 cytoskeletal organization, through fluorescence microscopy; and 3 membrane overexpression of adhesion molecules, employing ELISA and immunostaining. Upon stimulation with TNF-α (10 ng/mL for 20 h, for all three endothelial cells, the mechanical stiffness increased by about 50% with a mean apparent elastic modulus of E ~5 ± 0.5 kPa (~3.3 ± 0.35 kPa for the control cells; the density of F-actin filaments increased in the apical and median planes; and the ICAM-1 receptors were overexpressed compared with

Burkitt lymphoma in adolescents and young adults: management challenges

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Dozzo M

2016-12-01

Full Text Available Massimo Dozzo,1 Francesca Carobolante,1 Pietro Maria Donisi,2 Annamaria Scattolin,1 Elena Maino,1 Rosaria Sancetta,1 Piera Viero,1 Renato Bassan1 1Complex Operative Unit of Hematology, Ospedale dell’Angelo, 2Simple Departmental Operative Unit of Anatomic Pathology, Ospedale Ss. Giovanni e Paolo, Venice, Italy Abstract: About one-half of all Burkitt lymphoma (BL patients are younger than 40 years, and one-third belong to the adolescent and young adult (AYA subset, defined by an age between 15 and 25–40 years, based on selection criteria used in different reports. BL is an aggressive B-cell neoplasm displaying highly characteristic clinico-diagnostic features, the biologic hallmark of which is a translocation involving immunoglobulin and c-MYC genes. It presents as sporadic, endemic, or epidemic disease. Endemicity is pathogenetically linked to an imbalance of the immune system which occurs in African children infected by malaria parasites and Epstein–Barr virus, while the epidemic form strictly follows the pattern of infection by HIV. BL shows propensity to extranodal involvement of abdominal organs, bone marrow, and central nervous system, and can cause severe metabolic and renal impairment. Nevertheless, BL is highly responsive to specifically designed short-intensive, rotational multiagent chemotherapy programs, empowered by the anti-CD20 monoclonal antibody rituximab. When carefully applied with appropriate supportive measures, these modern programs achieve a cure rate of approximately 90% in the average AYA patient, irrespective of clinical stage, which is the best result achievable in any aggressive lymphoid malignancy to date. The challenges ahead concern the following: optimization of management in underdeveloped countries, with reduction of diagnostic and referral-for-care intervals, and the applicability of currently curative regimens; the development of lower intensity but equally effective treatments for frail or

Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain

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Ferrari F

2011-04-01

Full Text Available Flora Ferrari1, Simonetta Fiorentino1, Laura Mennuni1, Paolo Garofalo1, Ornella Letari1, Stefano Mandelli2, Antonio Giordani3, Marco Lanza1, Gianfranco Caselli11Department of Pharmacology and Toxicology; 2Department of Medicinal Chemistry; 3R&D Chemistry Drug Development and OS, Rottapharm S.p.A., Monza (MB, ItalyAbstract: Two decades of investigations have failed to unequivocally clarify the functions and the molecular nature of imidazoline-2 receptors (I2R. However, there is robust pharmacological evidence for the functional modulation of monoamino oxidase (MAO and other important enzyme activities by I2 site ligands. Some compounds of this class proved to be active experimental tools in preventing both experimental pain and opioid tolerance and dependence. Unfortunately, even though these compounds bind with high potency to central I2 sites, they fail to represent a valid clinical opportunity due to their pharmacokinetic, selectivity or side-effects profile. This paper presents the preclinical profile of a novel I2 ligand (2-phenyl-6-(1H-imidazol-1ylquinazoline; [CR4056] that selectively inhibits the activity of human recombinant MAO-A in a concentration-dependent manner. A sub-chronic four day oral treatment of CR4056 increased norepinephrine (NE tissue levels both in the rat cerebral cortex (63.1% ± 4.2%; P<0.05 and lumbar spinal cord (51.3% ± 6.7%; P < 0.05. In the complete Freund's adjuvant (CFA rat model of inflammatory pain, CR4056 was found to be orally active (ED50 = 5.8 mg/kg, by mouth [p.o.]. In the acute capsaicin model, CR4056 completely blocked mechanical hyperalgesia in the injured hind paw (ED50 = 4.1 mg/kg, p.o.; ED100 = 17.9 mg/kg, p.o.. This effect was dose-dependently antagonized by the non-selective imidazoline I2/α2 antagonist idazoxan. In rat models of neuropathic pain, oral administration of CR4056 significantly attenuated mechanical hyperalgesia and allodynia. In summary, the present study suggests a novel

Fuel cells science and engineering. Materials, processes, systems and technology. Vol. 1

Energy Technology Data Exchange (ETDEWEB)

Stolten, Detlef; Emonts, Bernd (eds.) [Forschungszentrum Juelich GmbH (DE). Inst. fuer Energieforschung (IEF), Brennstoffzellen (IEF-3)

2012-07-01

The first volume is divided in four parts and 22 chapters. It is structured as follows: PART I: Technology. Chapter 1: Technical Advancement of Fuel-Cell Research and Development (Dr. Bernd Emonts, Ludger Blum, Thomas Grube, Werner Lehnert, Juergen Mergel, Martin Mueller and Ralf Peters); 2: Single-Chamber Fuel Cells (Teko W. Napporn and Melanie Kuhn); 3: Technology and Applications of Molten Carbonate Fuel Cells (Barbara Bosio, Elisabetta Arato and Paolo Greppi); 4: Alkaline Fuel Cells (Erich Guelzow); 5: Micro Fuel Cells (Ulf Groos and Dietmar Gerteisen); 6: Principles and Technology of Microbial Fuel Cells (Jan B. A. Arends, Joachim Desloover, Sebastia Puig and Willy Verstraete); 7: Micro-Reactors for Fuel Processing (Gunther Kolb); 8: Regenerative Fuel Cells (Martin Mueller). PART II: Materials and Production Processes. Chapter 9: Advances in Solid Oxide Fuel Cell Development between 1995 and 2010 at Forschungszentrum Juelich GmbH, Germany (Vincent Haanappel); 10: Solid Oxide Fuel Cell Electrode Fabrication by Infiltration (Evren Gunen); 11: Sealing Technology for Solid Oxide Fuel Cells (K. Scott Weil); 12: Phosphoric Acid, an Electrolyte for Fuel Cells - Temperature and Composition Dependence of Vapor Pressure and Proton Conductivity (Carsten Korte); 13: Materials and Coatings for Metallic Bipolar Plates in Polymer Electrolyte Membrane Fuel Cells (Heli Wang and John A. Turner); 14: Nanostructured Materials for Fuel Cells (John F. Elter); 15: Catalysis in Low-Temperature Fuel Cells - An Overview (Sabine Schimpf and Michael Bron). PART III: Analytics and Diagnostics. Chapter 16: Impedance Spectroscopy for High-Temperature Fuel Cells (Ellen Ivers-Tiffee, Andre Leonide, Helge Schichlein, Volker Sonn and Andre Weber); 17: Post-Test Characterization of Solid Oxide Fuel-Cell Stacks (Norbert H. Menzler and Peter Batfalsky); 18: In Situ Imaging at Large-Scale Facilities (Christian Toetzke, Ingo Manke and Werner Lehnert); 19: Analytics of Physical Properties of Low

Calcium isotope signature: new proxy for net change in bone volume for chronic kidney disease and diabetic rats.

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Tanaka, Yu-Ki; Yajima, Nobuyuki; Higuchi, Yusuke; Yamato, Hideyuki; Hirata, Takafumi

2017-12-01

Herein, we measure the Ca isotope ratios ( 44 Ca/ 42 Ca and 43 Ca/ 42 Ca) in serum and bone samples collected from rats with chronic kidney disease (CKD) or diabetes mellitus (DM). For the serum samples, the isotope ratios are lower for the CKD (δ 44 Ca/ 42 Ca serum = 0.16 ± 0.11‰; 2SD, n = 6) and the DM (δ 44 Ca/ 42 Ca serum = -0.11 ± 0.25‰; 2SD, n = 7) rats than that for the control rats (δ 44 Ca/ 42 Ca serum = 0.25 ± 0.04‰; 2SD, n = 7). Bone samples from two distinct positions of 20 rats in total, namely, the center and proximal parts of the tibial diaphysis, are subject to Ca isotope analysis. The resulting δ 44 Ca/ 42 Ca values for the bone of the proximal part are about 0.3‰ lower than that for the serum samples from the same rats. The larger isotope fractionations between the serum and bone are consistent with previously reported data for vertebrate animals (e.g., Skulan and DePaolo, 1999), which suggests the preferential incorporation of lighter Ca isotopes through bone formation. For the bones from the control and CKD rats, there were no differences in the δ 44 Ca/ 42 Ca values between the positions of the bone. In contrast, the δ 44 Ca/ 42 Ca values of the bone for the DM rats were different between the positions of the bone. Due to the lower bone turnover rate for the DM rats, the δ 44 Ca/ 42 Ca for the middle of the diaphysis can reflect the Ca isotopes in the bone formed prior to the progression of DM states. Thus, the resulting δ 44 Ca/ 42 Ca values show a clear correlation with bone mineral density (BMD). This can be due to the release of isotopically lighter Ca from the bone to the serum. In the present study, our data demonstrate that the δ 44 Ca/ 42 Ca value for serum can be used as a new biomarker for evaluating changes in bone turnover rate, followed by changes in bone volume.

Chronotherapy with low-dose modified-release prednisone for the management of rheumatoid arthritis: a review

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Beltrametti SP

2016-11-01

Full Text Available Stefano Paolo Beltrametti,1 Aurora Ianniello,2 Clara Ricci3 1Department of Rheumatology, S. Andrea Hospital, Vercelli, 2Rheumatology Outpatient Clinic, Novara, 3Primula Multimedia S.p.A, Pisa, Italy Abstract: To date, rheumatoid arthritis (RA remains a debilitating, life-threatening disease. One major concern is morning symptoms (MS, as they considerably impair the patients’ quality of life and ability to work. MS change in a circadian fashion, resembling the fluctuations of inflammatory cytokines such as interleukin-6, whose levels are higher in RA patients compared to healthy donors. Conversely, serum levels of the potent anti-inflammatory glucocorticoid cortisol are similar to that of healthy subjects, suggesting an imbalance that sustains a pro-inflammatory state. From a therapeutic point of view, administering synthetic glucocorticoids (GCs to RA patients represents an optimal strategy to provide for the inadequate levels of cortisol. Indeed, due to their high efficacy in RA, GCs remain a cornerstone more than 60 years after their first introduction, and despite the development of a wide range of targeted agents. However, to improve safety, low-dose GCs have been introduced, that have demonstrated high efficacy in reducing disease activity, radiological progression, and improving patients’ signs and symptoms especially in early RA when added to conventional disease-modifying antirheumatic drugs. A further improvement has been provided by the development of modified-release prednisone, which, by taking advantage of the circadian fluctuations of inflammatory cytokines, cortisol and MS, is given at bedtime to be released approximately 4 hours later. Several studies have already demonstrated the efficacy of this agent on disease activity, MS, and quality of life in the setting of established RA. Moreover, preliminary studies have shown that this new formulation not only has no impact on the adrenal function, but likely improves it. This

Prospective study on prevalence, intensity, type, and therapy of acute pain in a second-level urban emergency department

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Mura P

2017-12-01

Full Text Available Paolo Mura,1 Elisabetta Serra,1 Franco Marinangeli,2 Sebastiano Patti,3 Mario Musu,1 Ilenia Piras,3 Maria Valeria Massidda,1 Giorgio Pia,3 Maurizio Evangelista,4 Gabriele Finco1 1Department of Medical Sciences “M. Aresu”, University of Cagliari, Cagliari, Italy; 2Department of Anesthesiology, Intensive Care and Pain Medicine, University of L’Aquila, L’Aquila, Italy; 3Department of Emergency Medicine, Santissima Trinità Hospital, Cagliari, Italy; 4Department of Anesthesiology and Pain Medicine, Cattolica University, Rome, Italy Aim: Pain represents the most frequent cause for patient admission to emergency departments (EDs. Oligoanalgesia is a common problem in this field. The aims of this study were to assess prevalence and intensity of pain in patients who visited a second-level urban ED and to evaluate the efficacy of pharmacological treatment administered subsequent to variations in pain intensity. Methods: A 4-week prospective observational study was carried out on 2,838 patients who visited a second-level urban ED. Pain intensity was evaluated using the Numeric Rating Scale at the moment of triage. The efficacy of prescribed analgesic therapy was evaluated at 30 and 60 minutes, and at discharge. Data concerning pain intensity were classified as absent, slight, mild, or severe. Pain was evaluated in relation to the prescribed therapy. Results: Pain prevalence was 70.7%. Traumatic events were the primary cause in most cases (40.44%, followed by pain linked to urologic problems (13.52%, abdominal pain (13.39%, and nontraumatic musculoskeletal pain (7.10%. Only 32.46% of patients were given pharmacological therapy. Of these, 76% reported severe pain, 19% moderate, and 5% slight, and 66% received nonsteroidal anti-inflammatory drugs or paracetamol, 4% opioids, and 30% other therapies. A difference of at least 2 points on the Numerical Rating Scale was observed in 84% of patients on reevaluation following initial analgesic therapy

Validation of exhaled volatile organic compounds analysis using electronic nose as index of COPD severity

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Finamore P

2018-05-01

Full Text Available Panaiotis Finamore,1 Claudio Pedone,1 Simone Scarlata,1 Alessandra Di Paolo,1 Simone Grasso,2 Marco Santonico,2 Giorgio Pennazza,2 Raffaele Antonelli Incalzi1 1Unit of Geriatrics, Campus Bio-Medico di Roma University, Rome, Italy; 2Unit of Electronics for Sensor Systems, Campus Bio-Medico di Roma University, Rome, Italy Aim: Six-minute walking test distance (6MWD and body mass index, obstruction, dyspnea and exercise (BODE index are measures of functional status in COPD patients, but require space, time and patient’s compliance. Exhaled volatile organic compounds (VOCs analysis via electronic nose is a quick and easy method that has already been used to discriminate COPD phenotypes. The aim of this study is to evaluate whether VOCs analysis can predict functional status and its variation over time in COPD patients.Methods: A monocentric prospective study with 1 year of follow-up was carried out. All patients underwent pulmonary function tests, arterial gas analysis, bioimpedance analysis, 6-minute walking test, and VOCs collection. Exhaled breath was collected with Pneumopipe® and analyzed using BIONOTE electronic nose. Outcomes prediction was performed by k-fold cross-validated partial least square discriminant analysis: accuracy, sensitivity and specificity as well as Cohen’s kappa for agreement were calculated.Results: We enrolled 63 patients, 60.3% men, with a mean age of 71 (SD: 8 years, median BODE index of 1 (interquartile range: 0–3 and mean 6MWD normalized by squared height (n6MWD of 133.5 (SD: 42 m/m2. The BIONOTE predicted baseline BODE score (dichotomized as BODE score <3 or ≥3 with an accuracy of 86% and quartiles of n6MWD with an accuracy of 79%. n6MWD decline more than the median value after 1 year was predicted with an accuracy of 86% by BIONOTE, 52% by Global Initiative for Chronic Obstructive Lung Disease (GOLD class and 78% by combined BIONOTE and GOLD class.Conclusion: Exhaled VOCs analysis identifies classes of BODE

Out of the Shadows

Science.gov (United States)

Byers, Nina; Williams, Gary

2010-12-01

Foreword Freeman J. Dyson; Introduction Nina Byers; 1. Hertha Aryton 1854-1923 Joan Mason; 2. Margaret Maltby 1860-1944 Peggy Kidwell; 3. Agnes Pockels 1862-1935 Gary A. Williams; 4. Marie Curie 1867-1934 A. Pais; 5. Henrietta Leavitt 1868-1921 Jean L. Turner; 6. Harriet Brooks 1876-1933 C. W. Wong; 7. Lise Meitner 1878-1968 Ruth Lewin Sime; 8. Emmy Noether 1882-1935 Nina Byers; 9. Inge Lehmann 1888-1993 Bruce A. Bolt; 10. Marietta Blau 1894-1970 Leopold Halpern and Maurice M. Shapiro; 11. Hertha Sponer 1895-1968 Helmut Rechenberg; 12. Irene Joliot-Curie 1897-1956 Hélène Langevin-Joliot and Pierre Radvanyi; 13. Katherine Burr Blodgett 1898-1979 Gary A. Williams; 14. Cecilia Payne Gaposchkin 1900-1979 Vera C. Rubin; 15. Mary Cartwright 1900-1998 Freeman J. Dyson; 16. Bertha Jeffreys 1903-1999 Ruth M. Williams; 17. Kathleen Yardley Lonsdale1903-1971 Judith Milledge; 18. Maria Goeppert Mayer 1906-1972 Steven A. Moszkowski; 19. Helen Megaw 1907-2002 A. Michael Glazer and Christine Kelsey; 20. Yvette Cauchois 1908-1999 Christiane Bonnelle; 21. Marguerite Perey 1909-1975 Jean-Pierre Adloff and George B. Kauffman; 22. Dorothy Crowfoot Hodgkin 1910-1994 Jenny P. Glusker; 23. Gertrude Scharff Goldhaber 1911-1998 Alfred Scharff Goldhaber; 24. Chien Shiung Wu 1912-1997 Noemie Bencze-Koller; 25. Margaret E. Burbidge 1919 Virginia Trimble; 26. Phyllis Freier 1921-1992 Cecil J. Waddington; 27. Rosalyn S. Yalow 1921 M. S. Dresselhaus and F. A. Stahl; 28. Esther Conwell 1922 Lewis Rothberg; 29. Cecile Dewitt-Morette 1922 Bryce DeWitt; 30. Yvonne Choquet-Bruhat 1923 James W. York Jr.; 31. Vera Rubin 1928 Robert J. Rubin; 32. Mildred S. Dresselhaus 1930 G. Dresselhaus and F. A. Stahl; 33. Myriam Sarachik 1933 Jonathan R. Friedman; 34. Juliet Lee-Franzini 1933 Paolo Franzini; 35. Helen T. Edwards 1936 John Peoples; 36. Mary K. Gaillard 1939 Andreszej Buras; 37. Renata Kallosh 1943 Andrei Linde and Michael Gutperle; 38. Jocelyn Bell Burnell 1943 Ferdinand V. Coroniti and Gary A

The effects of patient and physician characteristics on early outpatient satisfaction with substance dependence care: results of the SUBUSQOL study

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Bourion-Bédès S

2017-05-01

Full Text Available Stéphanie Bourion-Bédès,1–3 Raymund Schwan,2 Paolo Di Patrizio,2 Guillaume Vlamynck,2 Sarah Viennet,2 Maxime Schvartz,2 Anne Gaunard,2 Alex Bédès,4 Isabelle Clerc-Urmès,5 Cédric Baumann3,5 1Regional Medical and Psychological Service (SMPR, 2CSAPA (Healthcare Center of Accompaniment and Prevention in Addictology, University Hospital of Nancy, 3EA4360 APEMAC, University of Lorraine, Nancy, 4ANPAA 15-CSAPA (Healthcare Center of Accompaniment and Prevention in Addictology, Saint-Flour, Cantal, 5Platform of Clinical Research Facility PARC, Unit MDS, University Hospital of Nancy, Nancy, France Background: Although patient perceptions of health care have increasingly been explored in the literature, little is known about care satisfaction among individuals with substance dependence. This exploratory study assessed the relationships between patient and physician characteristics and early outpatient satisfaction with care for alcohol and opioid dependence. Methods: Satisfaction was assessed using a multidimensional, self-administered and validated questionnaire during the early care process among a prospective outpatient cohort. In addition to measuring satisfaction and obtaining sociodemographic and clinical data, this study collected data on the self-reported health status and physician characteristics at inclusion. Cross-sectional analysis with multiple linear regression was performed to identify the variables associated with satisfaction level. Results: A total of 249 outpatients were included, and 63.8% completed the satisfaction questionnaire. Patients without a history of previous care for substance dependence were more satisfied with the appointment-making process (β=7.2; P=0.029 and with the doctor consultation (β=10.3; P=0.003 than those who had received care previously. Neither sociodemographic characteristics nor self-reported health status was associated with outpatient satisfaction. Conclusion: The factors that affect patients�

Ammonium glycyrrhizinate-loaded niosomes as a potential nanotherapeutic system for anti-inflammatory activity in murine models

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Marianecci C

2014-01-01

Full Text Available Carlotta Marianecci,1 Federica Rinaldi,1 Luisa Di Marzio,2 Marica Mastriota,3 Stefano Pieretti,3 Christian Celia,2,4 Donatella Paolino,5 Michelangelo Iannone,6,7 Massimo Fresta,5 Maria Carafa11Department of Drug Chemistry and Technologies, University Sapienza of Rome, Rome, 2Department of Pharmacy, University G d'Annunzio of Chieti of Pescara, Chieti, 3Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanità, Rome, Italy; 4Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX, USA; 5Department of Health Sciences, University Magna Graecia of Catanzaro, University Campus S Venuta, Building of BioSciences, Germaneto, 6ARPA Calabria, Environmental Epidemiology Center, 7CNR, Neuroscience Institute, Pharmacology Section, Complesso "Nini Barbieri", Roccelletta di Borgia, ItalyBackground: Liquorice extracts demonstrate therapeutic efficacy in treating dermatitis, eczema, and psoriasis when compared with corticosteroids. In this work, nonionic surfactant vesicles (niosomes, NSVs containing polysorbate 20 (Tween 20, cholesterol, and cholesteryl hemisuccinate at different molar concentrations were used to prepare monoammonium glycyrrhizinate (AG-loaded NSVs. The anti-inflammatory properties of AG-loaded NSVs were investigated in murine models.Methods: The physicochemical properties of the NSVs were characterized using dynamic light scattering. The fluidity of the lipid bilayer was evaluated by measuring the fluorescence intensity of diphenylhexatriene. The drug entrapment efficiency of AG was assessed using high-performance liquid chromatography. The physicochemical stability of the NSVs was evaluated as a function of time using dynamic light scattering combined with Turbiscan Lab® Expert analysis. Serum stability was determined by incubating the NSVs with 10% v/v fetal bovine serum. The cytotoxic effects of the NSVs were investigated in human dermal fibroblasts using the Trypan blue dye

PREFACE: 32nd UIT (Italian Union of Thermo-fluid-dynamics) Heat Transfer Conference

Science.gov (United States)

2014-11-01

volume would like to sincerely thank the authors for presenting their works at the conference and in this special issue. Special thanks are also due to the Scientific Committee, to all the reviewers, and to all the authors for their accurate revision process of each paper for this special issue. Special thanks go to the Organizing Committee, chaired by Prof. Paolo Di Marco. Walter Grassi (Chairman of the Scientific Committee), Alessandro Franco, Nicola Forgione, Daniele Testi - Editors of the Special Issue

Therapeutic interventions and adjustments in the management of Parkinson disease: role of combined carbidopa/levodopa/entacapone (Stalevo®

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Paolo Solla

2010-08-01

Full Text Available Paolo Solla, Antonino Cannas, Francesco Marrosu, Maria Giovanna MarrosuMovement Disorders Center, Institute of Neurology, University of Cagliari, Cagliari, ItalyAbstract: Parkinson disease (PD is a neurodegenerative disorder characterized by 3 cardinal motor symptoms: resting tremor, rigidity, and bradykinesia. Since its introduction 40 years ago, levodopa has represented the gold standard for dopaminergic stimulation therapy in patients with PD. Levodopa is routinely combined with a dopa-decarboxylase inhibitor (DDCI to prevent the conversion of levodopa into dopamine in peripheral circulation. However, up to 80% of patients treated with continuous levodopa manifest the onset of disabling motor complications capable of producing an adverse effect on quality of life as the disease progresses. In recent years, a new, safe, and efficacious armamentarium of treatment options has been provided by the marketing of the catechol-O-methyltransferase (COMT inhibitor, entacapone, a peripheral blocker of dopa to 3-0-methyldopa metabolism, which increments levodopa brain availability. When administered with levodopa, entacapone conjugates the rapid onset of levodopa-induced effects with a protracted efficiency, thus providing additional benefits to classic levodopa treatment by increasing “on” time in fluctuating PD patients, and theoretically providing a more continuous and physiological-like stimulation of dopamine receptors implying a reduced risk of motor complications. In this context, the use of a single administration of combined ­carbidopa/levodopa/entacapone (Stalevo® in the treatment of PD affords clinical improvements similar to those obtained by 2 separate tablets (ie, levodopa/DDCI and entacapone, although the former produces a more positive effect on quality of life than the latter. Additionally, the STalevo Reduction In Dyskinesia Evaluation (STRIDE-PD study was designed with the aim of demonstrating that the combination of levodopa

An overview on the history of pedology and soil mapping in Italy

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Calzolari, C.

2012-04-01

In Italy, the word pedology (pedologia) was introduced in a text book as synonym of soil science for the first time in 1904 by Vinassa de Regny. In the literature, the term cohabitates with the words agrology (agrologia), agro-geology (agro-geologia), agricultural geognostic (geognostica agraria), geopedology (geo-pedologia) used in different historical moments by differently rooted soil scientists. When early pedologists started with systematic studies of soils, their characteristics and geography, they were strongly influenced by their cultural background, mainly geology and agro-chemistry. Along the time, the soil concept evolved, as did the concept of pedology, and this is somehow witnessed by the use of different Italian words with reference to soil: suolo, terreno, terra. Differently from agro-chemists, early pedologists based the soil study on the field description of soil profile. This was firstly based on the vertical differentiation between humus rich layers and "inactive" layers and later on, as long as the discipline evolved, on the presence of genetic horizons. The first complete soil map of Italy is dated 1928. Its Author, the geologist De Angelis d'Ossat, was the president of the organising committee of the 1924 International Soil Conference of Rome, where the International Society of Soil Science was founded. The map was based on the geological map of Italy, drafted in scale 1:1,000,000 after the creation of the Kingdom of Italy in 1861. The internal disputes within the Geological Society, together with the scarce interest of most of geologists for soil, did not facilitate the birth of a central soil survey. Soil mapping was mainly conducted by universities and research institutes, and we had to wait until 1953 for a new soil map (scale 1:3,125,000) at national level to be realised by Paolo Principi, based on literature data. In 1966 a new 1:1,000,000 soil map of Italy was eventually published by a national committee, led by Fiorenzo Mancini. This

Proceedings of the 19th ASPA Congress, Cremona, June 7-10, 2011

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Guest Editor: Giacomo Pirlo

2011-06-01

Full Text Available The 19th Congress of the Animal Science and Production Association (ASPA, is held in the capital of one of the main European regions for animal production: Cremona. Despite its Gallic origin (Carra = rock, the name Cremona means big cream in modern Italian, in a clear allusion to milk. In this Congress, 153 oral presentations and 165 posters are presented, for a total of 318 scientific contributions. The Congress sessions with their relative number of papers are listed as follows: Animal breeding and genetics 87, Nutrition and feeding 57, Dairy production 40, Meat production 46, Animal welfare, Health and behaviour 37, Poultry and rabbit production 28 and Aquaculture 23. I would like to point out that 4 main lectures will be presented in the Animal breeding and genetics and Nutrition and feeding sessions (two in each, and that the Consiglio per la Ricerca in Agricoltura (Agricultural Research Council, the Agricultural Ministery research agency, which took charge of organizing the Congress, will award a prize for the best work here presented by young researchers. I would thank, first of all, Prof. Paolo Cescon, President of the Congress, for the contribution of all the CRA in organizing this event. I would also thank all the members of the Scientific Committee, dr. Riccardo Aleandri (President, dr. Fabio Abeni, dr. Fabiola Canavesi, dr. Giacinto Della Casa and dr. Marisanna Speroni, and of the Organizing Committee, dr. Giovanni Lo Piparo (President, dr. Stefania Barzaghi, dr. Maurizio Capelletti, dr. Giorgio Giraffa and dr. Luciano Migliorati. A special thanks to the secretary components, Maria Dissegna and Patrizia Re, assisted by Claudia Federici, Francesca Petrera, Miriam Odoardi, Maddalena Carli, Caterina Sanna, Stefania Marruso, Leonardo Boselli, Milena Rosi and Aldo Dal Prà. A special acknowlegment to Giacomo Pirlo, the real driving force organizing the Congress, a tireless and enthusiastic embroiderer of opportunities in scientific and

Differences in onset and abuse/dependence episodes between prescription opioids and heroin: results from the National Epidemiologic Survey on Alcohol and Related Conditions

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Mannelli P

2011-05-01

Full Text Available Li-Tzy Wu1, George E Woody2, Chongming Yang3, Paolo Mannelli1, Dan G Blazer11Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Duke University Medical Center, Durham, NC, USA; 2Department of Psychiatry, University of Pennsylvania School of Medicine, University of Pennsylvania and Treatment Research Institute, Philadelphia, PA, USA; 3Social Science Research Institute, Duke University, Durham, NC, USAObjectives: To examine patterns of onset and abuse/dependence episodes of prescription opioid (PO and heroin use disorders in a national sample of adults, and to explore differences by gender and substance abuse treatment status.Methods: Analyses of data from the 2001–2002 National Epidemiologic Survey on Alcohol and Related Conditions (N = 43,093.Results: Of all respondents, 5% (n = 1815 reported a history of nonmedical PO use (NMPOU and 0.3% (n = 150 a history of heroin use. Abuse was more prevalent than dependence among NMPOUs (PO abuse, 29%; dependence, 7% and heroin users (heroin abuse, 63%; dependence, 28%. Heroin users reported a short mean interval from first use to onset of abuse (1.5 years or dependence (2.0 years, and a lengthy mean duration for the longest episode of abuse (66 months or dependence (59 months; the corresponding mean estimates for PO abuse and dependence among NMPOUs were 2.6 and 2.9 years, respectively, and 31 and 49 months, respectively. The mean number of years from first use to remission from the most recent episode was 6.9 years for PO abuse and 8.1 years for dependence; the mean number of years from first heroin use to remission from the most recent episode was 8.5 years for heroin abuse and 9.7 years for dependence. Most individuals with PO or heroin use disorders were remitted from the most recent episode. Treated individuals, whether their problem was heroin or POs, tended to have a longer mean duration of an episode than untreated individuals.Conclusion: Periodic remissions

Toward an integrated quasi-operational air quality analysis and prediction system for South America

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Hoshyaripour, Gholam Ali; Brasseur, Guy; Petersen, Katinka; Bouarar, Idiir; Andrade, Maria de Fatima

2015-04-01

Recent industrialization and urbanization in South America (SA) have notably exacerbated the air pollution with adverse impacts on human health and socio-economic systems. Consequently, there is a strong demand for developing ever-better assessment mechanisms to monitor the air quality at different temporal and spatial scales and minimize its damages. Based on previous achievements (e.g., MACC project in Europe and PANDA project in East Asia) we aim to design and implement an integrated system to monitor, analyze and forecast the air quality in SA along with its impacts upon public health and agriculture. An initiative will be established to combine observations (both satellite and in-situ) with advanced numerical models in order to provide a robust scientific basis for short- and long-term decision-making concerning air quality issues in SA countries. The main objectives of the project are defined as 3E: Enhancement of the air quality monitoring system through coupling models and observations, Elaboration of comprehensive indicators and assessment tools to support policy-making, Establishment of efficient information-exchange platforms to facilitate communication among scientists, authorities, stockholders and the public. Here we present the results of the initial stage, where a coarse resolution (50×50 km) set up of Weather Research and Forecast model with Chemistry (WRF-Chem) is used to simulate the air quality in SA considering anthropogenic, biomass-burning (based on MACCity, FINN inventories, respectively) and biogenic emissions (using MEGAN model). According to the availability of the observation data for Metropolitan Area of São Paulo, August 2012 is selected as the simulation period. Nested domains with higher resolution (15×15 km) are also embedded within the parent domain over the megacities (Sao Paolo and Rio de Janeiro in Brazil and Buenos Aires in Argentina), which account for the major anthropogenic emission sources located along coastal regions

Highlights of Astronomy, Vol. 15

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Corbett, Ian

2010-11-01

Preface; Part I. Gruber Cosmology Prize Lecture; Part II. Invited Discourses; Part III. Joint Discussions: 1. Dark matter in early-type galaxies Léon V. E. Koopmans and Tommaso Treu; 2. Diffuse light in galaxy clusters Magda Arnaboldi and Ortwin Gerhard; 3. Neutron stars - timing in extreme environments Tomaso Belloni, Mariano Méndez and Chengmin Zhang; 4. Progress in understanding the physics of Ap and related stars Margarida Cunha; 5. Modelling the Milky Way in the age of Gaia Annie C. Robin; 6. Time and astronomy Pascale Defraigne; 7. Astrophysical outflows and associated accretion phenomena Elisabete M. de Gouveia Dal Pino and Alex C. Raga; 8. Hot interstellar matter in elliptical galaxies Dong-Woo Kim and Silvia Pellegrini; 9. Are the fundamental constants varying with time? Paolo Molaro and Elisabeth Vangioni; 10. 3D views on cool stellar atmospheres - theory meets observation K. N. Nagendra, P. Bonifacio and H. G. Ludwig; 11. New advances in helio- and astero-seismology; 12. The first galaxies - theoretical predictions and observational clues; 13. Eta Carinae in the context of the most massive stars Theodore R. Gull and Augusto Damineli; 14. The ISM of galaxies in the far-infrared and sub-millimetre; 15. Magnetic fields in diffuse media Elisabete M. de Gouveia Dal Pino and Alex Lazarian; 16. IHY global campaign - whole heliosphere interval; Part IV. Special Sessions: SpS 1. IR and sub-mm spectroscopy - a new tool for studying stellar evolution Glenn Wahlgren, Hans Käufl and Florian Kerber; SpS 2. The international year of astronomy Pedro Russo, Catherine Cesarsky and Lars Lindberg Christensen; SpS 3. Astronomy in Antarctica in 2009 Michael G. Burton; SpS 4. Astronomy education between past and future J. P. De Greve; SpS 5. Accelerating the rate of astronomical discovery Ray P. Norris; SpS 6. Planetary systems as potential sites for life Régis Courtin, Alan Boss and Michel Mayor; SpS 7. Young stars, brown dwarfs, and protoplanetary disks Jane Gregorio

[Exploring life-experience of the staff and volunteers assisting pediatric patients in end-of-life situations] [Article in Italian] • I vissuti dello staff e dei volontari che assistono pazienti pediatrici terminali

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Rosapia Lauro Grotto

2014-06-01

philosophical approaches to the issues raised by palliative care in paediatric settings.Articoli Selezionati del Congresso “Medicina Narrativa e Comunicazione nella Pratica Clinica” ·  Cagliari · 14 Aprile 2014 Guest Editors: Massimiliano Zonza, Vassilios Fanos, Gian Paolo Donzelli

Technial Programme Committee

Science.gov (United States)

2014-06-01

Chairpersons Dr Dinesh Sathyamoorthy, Science & Technology Research Institute for Defence (STRIDE), Ministry of Defence, Malaysia Associate Professor Sr Dr Abdul Rashid Mohamed Shariff, Universiti Putra Malaysia (UPM), Malaysia Dr Ahmad Fikri Abdullah, Universiti Putra Malaysia (UPM), Malaysia Dr Farrah Melissa Muharram, Universiti Putra Malaysia (UPM), Malaysia Members Professor Dr Li Jing, Beijing Normal University, China Professor Dr Iyyanki Muralikrishna, Administrative Staff College of India (ASCI), India Professor Dr Alias Abdul Rahman, Universiti Teknologi Malaysia (UTM), Malaysia Professor Dr Ismat Mohamed El Hassan, King Saud University, Saudi Arabia Professor Dr George Miliaresis, Open University of Cyprus, Cyprus Professor Dr Christine Pohl, Universiti Teknologi Malaysia (UTM), Malaysia Professor Dr Mahender Kotha, Goa University, India Associate Professor Dr Paolo Gamba, University of Pavia, Italy Associate Professor Dr Behara Seshadri Daya Sagar, Indian Statistical Institute (ISI), India Associate Professor Sr Ranjit Singh, Infrastructure University Kuala Lumpur (IUKL), Malaysia Associate Professor Dr Abdul Nasir Matori, Universiti Teknologi Petronas (UTP), Malaysia Associate Dr Lucian Dragut, West University of Timişoara, Romania Associate Professor Dr Saied Pirasteh, Islamic Azad University, Iran Associate Professor Dr Peter Yuen, Cranfield University, United Kingdom Associate Professor Dr Lim Hwee San, Universiti Sains Malaysia (USM), Malaysia Associate Professor Dr Wayan Suparta, Universiti Kebangsaan Malaysia (UKM), Malaysia Associate Professor Dr Tuong Thuy Vu, The University of Nottingham Malaysia Campus, Malaysia Associate Professor Dr Maged Mahmoud Marghany, Universiti Teknologi Malaysia (UTM), Malaysia Associate Professor Dr Rami Al-Ruzouq, University of Sharjah, UAE Associate Professor Dr Biswajeet Pradhan, Universiti Putra Malaysia (UPM), Malaysia Associate Professor Dr Helmi Zulhaidi Mohd Shafri, Universiti Putra Malaysia (UPM), Malaysia

Calcitonin gene-related peptide receptor as a novel target for the management of people with episodic migraine: current evidence and safety profile of erenumab

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Giamberardino MA

2017-12-01

Full Text Available Maria Adele Giamberardino,1,* Giannapia Affaitati,1,* Raffaele Costantini,2 Francesco Cipollone,3,* Paolo Martelletti4,* 1Department of Medicine and Science of Aging, Headache Center, Geriatrics Clinic and Ce.S.I.-Met, “G. D’Annunzio” University of Chieti, Chieti, Italy; 2Department of Medical, Oral and Biotechnological Sciences, Institute of Surgical Pathology, “G. D’Annunzio” University of Chieti, Chieti, Italy; 3Department of Medicine and Science of Aging, Medical Clinic and Ce.S.I.-Met, “G. D’Annunzio” University of Chieti, Chieti, Italy; 4Department of Clinical and Molecular Medicine, Regional Referral Headache Center, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy *These authors contributed equally to this work Abstract: Migraine is a highly disabling neurological condition, and preventative treatment still remains problematic, due to aspecificity of the majority of the currently available prophylactic drugs. Calcitonin-gene-related peptide (CGRP plays a crucial role in migraine pathophysiology; agents aimed at blocking its activity have, therefore, been developed in recent years, among which are monoclonal antibodies (mAbs against CGRP, to prevent migraine. Erenumab is the only mAb that targets the CGRP receptor instead of the ligand, with high specificity and affinity of binding. This review will report on the most recent data on erenumab characteristics and on the results of clinical trials on its employment in the prevention of episodic migraine (4–14 monthly migraine days: one Phase II and two Phase III trials (completed and one Phase III trial (ongoing. Monthly subcutaneous administration (70 mg or 140 mg of erenumab vs placebo for 3–6 months showed significantly higher efficacy in reducing the mean monthly number of migraine days and the use of migraine-specific medication, and in decreasing physical impairment and impact of migraine on everyday activities (P<0.001. A favorable safety profile

Health Promotion in Canada: perspectives & future prospects - doi:10.5020/18061230.2007.p3

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Blake Poland

2012-01-01

Full Text Available Thank-you for the opportunity to be with you today in this fascinating panel on the state of health promotion in Brazil, Canada and around the world. It is a great pleasure to be here, and to share my thoughts and reflections with you, not as na expert here to tell you how it ‘should’ be, but as a colleague interested in dialogue around points of mutual concern. I feel we have much to learn from what has been happening here in Brazil, and the work of Paolo Freire and many contemporary colleagues who continue this tradition of critical pedagogy for health (like my colleague and friend here at UNIFOR, Dr. Francisco Cavalcante Jr.. So in this spirit of friendship, dialogue and mutual learning, I will be very frank with you about the lessons learned in Canada, including some of our failures and mistakes which I hope you can successfully avoid. Also, I offer my apologies for not being able to speak with you in your own language. I wish to thank my friends Nicolas Ayres and Francisco Cavalcante Jr. For their assistance with translation. In addition to a brief overview of the development of health promotion in Canada, I would like to share some reflections on the social, political and economic context in which the field has evolved, both in Canada and internationally. I Will address three (3 key tensions I see in the field at the moment (from a Canadian perspective, and reflect on our successes and our failures. I will close with a few thoughts on future prospects and some of the challenges that I see that lie ahead. I would like to emphasize that any brief history of health promotion in Canada, and any assessment of its strengths, contributions and failures is inherently ‘subjective’ and idiosyncratic. Rather than repeat the work of other analysts and commentators (see for example – cite PHAC/HC docs, I offer my observations based on over a decade of involvement in the field (including involvement in the Critical Social Science and Health

La dictadura militar y la Universidad de São Paulo: el montaje del aparato de represión (1964-1972

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Matheus Cardoso da Silva

2014-01-01

Full Text Available Resumen: El artículo aborda el proceso de montaje del aparato de represión durante la dictadura militar (1964-1972 al interior de la Universidad de São Paulo, que tenía como objetivos la vigilancia, censura y  represión para con los docentes y estudiantes. Para desarrollar esas actividades se dio la supervisión de la vida cotidiana en la universidad, tanto en las actividades académicas como en las personales, resultado de lo cual se dieron diversas detenciones, procesamientos e, incluso, asesinatos. El periodo de tiempo analizado se ha dividido en tres momentos, cada uno de los cuales se describe a detalle a lo largo del artículo: el primero, a partir de 1964, mediante la vigilancia emprendida por la DOPS; el segundo inicia con la promulgación del Acta Institucional Número 5 (AI-5; y, el tercero inicia con la creación del Asesoramiento Especial y Seguridad de la Información (AESI en todas las universidades, a partir de 1972. Durante este último momento se logró la distensión política del régimen militar, caminando hacia el proceso de apertura, aunque aún en nuestros días quedan resabios de las políticas de vigilancia de la época. Palabras clave: dictadura, Universidad de São Paulo, aparato de vigilancia.   Abstract: This paper describes the process of mounting the repression apparatus during the military dictatorship (1964-1972 inside the Sao Paolo University having as main objectives monitoring, censorship and repression of teachers and students. To accomplish these objectives, daily life in college, including academic and personal activities, was supervised resulting in several arrests, prosecutions and even murders. The analyzed period of time is divided into three stages. Each of them is described in detail throughout this paper. The first one, starting from 1964, describes the monitoring undertaken by the DOPS*; the second one starts with the enactment of the Institutional Act 5 (IA-5; and the third one starts with

Operative and nonoperative management for renal trauma: comparison of outcomes. A systematic review and meta-analysis

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Mingoli A

2017-08-01

Full Text Available Andrea Mingoli,1,2 Marco La Torre,1,2 Emanuele Migliori,1,2 Bruno Cirillo,1,2 Martina Zambon,1,2 Paolo Sapienza,1,2 Gioia Brachini1,2 1Emergency Department, 2Department of Surgery P Valdoni, Policlinico Umberto I, Sapienza University, Rome, Italy Introduction: Preservation of kidney and renal function is the goal of nonoperative management (NOM of renal trauma (RT. The advantages of NOM for minor blunt RT have already been clearly described, but its value for major blunt and penetrating RT is still under debate. We present a systematic review and meta-analysis on NOM for RT, which was compared with the operative management (OM with respect to mortality, morbidity, and length of hospital stay (LOS. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-analyses statement was followed for this study. A systematic search was performed on Embase, Medline, Cochrane, and PubMed for studies published up to December 2015, without language restrictions, which compared NOM versus OM for renal injuries. Results: Twenty nonrandomized retrospective cohort studies comprising 13,824 patients with blunt (2,998 or penetrating (10,826 RT were identified. When all RT were considered (American Association for the Surgery of Trauma grades 1–5, NOM was associated with lower mortality and morbidity rates compared to OM (8.3% vs 17.1%, odds ratio [OR] 0.471; 95% confidence interval [CI] 0.404–0.548; P<0.001 and 2% vs 53.3%, OR 0.0484; 95% CI 0.0279–0.0839, P<0.001. Likewise, NOM represented the gold standard treatment resulting in a lower mortality rate compared to OM even when only high-grade RT was considered (9.1% vs 17.9%, OR 0.332; 95% CI 0.155–0.708; P=0.004, be they blunt (4.1% vs 8.1%, OR 0.275; 95% CI 0.0957–0.788; P=0.016 or penetrating (9.1% vs 18.1%, OR 0.468; 95% CI 0.398–0.0552; P<0.001. Conclusion: Our meta-analysis demonstrated that NOM for RT is the treatment of choice not only for AAST grades 1 and 2, but also for higher

Intensities of drilling predation of molluscan assemblages in intertidal and subtidal soft substrates in the Persian (Arabian) Gulf

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Handler, Sabine M.; Albano, Paolo G.; Bentlage, Rudolf; Drummond, Hannah; García-Ramos, Diego A.; Zuschin, Martin

2016-04-01

Intensities of drilling predation of molluscan assemblages in intertidal and subtidal soft substrates in the Persian (Arabian) Gulf Sabine Maria Handler1, Paolo G. Albano1, Rudolf Bentlage2, Hannah Drummond2, D.A. García-Ramos1, Martin Zuschin1 1 Department of Paleontology, University of Vienna, Austria 2 St. Lawrence University, Canton, New York 13617, USA Trace fossils left by predators in the skeleton of their prey are arguably one of the most powerful sources of direct data on predator-prey interactions available in the fossil record. Drill holes, especially those attributed to naticid and muricid gastropods, are unambiguous marks of predation and allow discriminating between successful and unsuccessful predation attempts (complete and incomplete holes, respectively). Latitude and water depth influence drilling frequency. We inspected death assemblages of an intertidal flat and of two subtidal (water depth between 6 and 20 m) sandy sites in the Persian (Arabian) Gulf, off the coast of the United Arab Emirates, to determine the patterns of predation on shelled molluscs along the depth gradient. The study is based on ~7,000 and ~60,000 shells from the intertidal and subtidal, respectively. Drilling Frequency (DF, the number of drilled individuals), Incomplete Drilling Frequency (IDF, number of incomplete drill holes), and Prey Effectiveness (ratio between the number of incomplete drill holes and the total number of drilling attempts) were used as metrics of drilling intensity. We observed major differences between the intertidal and subtidal study areas. Drilling frequencies were generally remarkably low and intertidal flats showed a much lower drilling frequency than the subtidal (1.4% and 6.7%, respectively). In the subtidal, we observed significant differences of drilling intensity among bivalve species and between the two sites. However, predation metrics did not correlate with environmental factors such as substrate type and depth, nor with species life

Cost of human immunodeficiency virus infection in Italy, 2007–2009: effective and expensive, are the new drugs worthwhile?

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Rizzardini G

2012-09-01

Full Text Available Giuliano Rizzardini,1 Umberto Restelli,2 Paolo Bonfanti,3 Emanuele Porazzi,2 Elena Ricci,1 Emanuela Foglia,2 Laura Carenzi,1 Davide Croce21First Infectious Diseases Department, "Luigi Sacco" Hospital, Milan; 2Centre for Research on Health Economics, Social, and Health Care Management, Università Carlo Cattaneo, Castellanza; 3Infectious Diseases Department, "Alessandro Manzoni" Hospital, Lecco, ItalyBackground: In recent years, the increased efficacy and effectiveness of antiretroviral treatment has led to longer survival of patients infected with human immunodeficiency virus (HIV, but has also raised the question of what happens to consumption of resources. Early highly active antiretroviral treatment (HAART, management of hepatitis C virus (HCV coinfection, and expensive newly marketed drugs may affect the economic sustainability of treatment from the point of view of the National Healthcare Services. The present study aimed to provide information on the economic burden of HIV-positive patients resident in the Lombardy region using a three-year time horizon.Methods: This was a retrospective, observational, budget impact study, based on information collected for the period 2007–2009, including hospitalizations, outpatient services, and HAART and non-HAART drug utilization. Patients with confirmed HIV infection, aged ≥ 18 years, resident in the Lombardy region, and followed at the "L Sacco" Hospital in Milan from 2007 to 2009 were eligible.Results: A total of 483 patients (mean age 44.1 years were included in the study. The mean CD4+ cell count increased over the study period from 462 ± 242 cells/mm3 in 2007, to 513 ± 267 cells/mm3 in 2008, to 547 ± 262 cells/mm3 in 2009. In total, 162 subjects (33.5% were coinfected with HCV. Hospitalizations and HAART costs increased from 2007 to 2009, whereas outpatient visits and non-HAART drug costs decreased slightly over time. The total cost increase was also significant when limiting the analysis

Effect of noninvasive mechanical ventilation in elderly patients with hypercapnic acute-on-chronic respiratory failure and a do-not-intubate order

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Paolo Scarpazza

2008-10-01

Full Text Available Paolo Scarpazza1, Cristoforo Incorvaia2, Giuseppe di Franco1, Stefania Raschi1, Pierfranco Usai1, Monica Bernareggi1, Cristiano Bonacina1, Chiara Melacini1, Silvia Vanni1, Serena Bencini1, Chiara Pravettoni2, Giuseppe Di Cara3, Mona-Rita Yacoub4, Gian Galeazzo Riario-Sforza2, Enrico Guffanti5, Walter Casali11Divisione di Broncopneumotisiologia, Ospedale Civile, Vimercate, Italy; 2Pulmonary rehabilitation, Istituti Clinici di Perfezionamento, Milan, Italy; 3University Department of Medical and Surgical Specialties and Public Health, Perugia, Italy; 4Allergy and Immunology Unit, IRCCS San Raffaele Hospital, Milan, Italy; 5Pulmonary rehabilitation, INRCA, Casatenovo, ItalyAbstract: Noninvasive mechanical ventilation (NIMV is effective in the treatment of patients with acute respiratory failure (ARF. It proved to reduce the need of endotracheal intubation (ETI, the incidence of ETI-associated pneumonia, and mortality compared to nonventilated patients. A particular aspect concerns the outcome of NIMV in patients referring to an emergency room (ER for ARF, and with a do-not-intubate (DNI status due to advanced age or critical conditions. The aim of our study is to assess the outcome of NIMV in a group of elderly patients with acute hypercapnic ARF who had a DNI status. An overall number of 62 subjects (30 males, 32 females, mean age 81 ± 4.8 years, range 79–91 years referred to our semi-intensive respiratory department were enrolled in the study. The underlying diseases were severe chronic obstructive pulmonary disease (COPD in 50/62 subjects, restrictive thoracic disorders in 7/62 subjects, and multiorgan failure in 5/62 subjects. Fifty-four/62 patients were successfully treated with NIMV while 2/62 did not respond to NIMV and were therefore submitted to ETI (one survived. Among NIMV-treated patients, death occurred in 6 patients after a mean of 9.9 days; the overall rate of NIMV failure was 12.9%. Negative prognostic factors for NIMV response

Protein networks in induced sputum from smokers and COPD patients

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Baraniuk JN

2015-09-01

Full Text Available James N Baraniuk,1 Begona Casado,1 Lewis K Pannell,2 Peter B McGarvey,3 Piera Boschetto,4 Maurizio Luisetti,5,† Paolo Iadarola6 1Division of Rheumatology, Immunology and Allergy, Georgetown University, Washington, DC, 2Proteomics and Mass Spectrometry Laboratory, Mitchell Cancer Center, University of South Alabama, Mobile, AL, 3Innovation Center for Biomedical Informatics, Georgetown University, Washington, DC, USA; 4Department of Medical Sciences, University of Ferrara, Ferrara, 5SC Pneumologia, Dipartimento Medicina Molecolare, Fondazione IRCCS Policlinico San Matteo, 6Lazzaro Spallanzani Department of Biology and Biotechnology, University of Pavia, Pavia, Italy †Maurizio Luisetti passed away on October 20, 2014 Rationale: Subtypes of cigarette smoke-induced disease affect different lung structures and may have distinct pathophysiological mechanisms. Objective: To determine if proteomic classification of the cellular and vascular origins of sputum proteins can characterize these mechanisms and phenotypes. Subjects and methods: Individual sputum specimens from lifelong nonsmokers (n=7 and smokers with normal lung function (n=13, mucous hypersecretion with normal lung function (n=11, obstructed airflow without emphysema (n=15, and obstruction plus emphysema (n=10 were assessed with mass spectrometry. Data reduction, logarithmic transformation of spectral counts, and Cytoscape network-interaction analysis were performed. The original 203 proteins were reduced to the most informative 50. Sources were secretory dimeric IgA, submucosal gland serous and mucous cells, goblet and other epithelial cells, and vascular permeability. Results: Epithelial proteins discriminated nonsmokers from smokers. Mucin 5AC was elevated in healthy smokers and chronic bronchitis, suggesting a continuum with the severity of hypersecretion determined by mechanisms of goblet-cell hyperplasia. Obstructed airflow was correlated with glandular proteins and lower levels of

VizieR Online Data Catalog: Solar neighborhood. XXXVII. RVs for M dwarfs (Benedict+, 2016)

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Benedict, G. F.; Henry, T. J.; Franz, O. G.; McArthur, B. E.; Wasserman, L. H.; Jao, W.-C.; Cargile, P. A.; Dieterich, S. B.; Bradley, A. J.; Nelan, E. P.; Whipple, A. L.

2017-05-01

, National optical astronomy observatory (WIYN) 3.5m (Horch et al. 2012, Cat. J/AJ/143/10). Where available, we use astrometric observations from HST instruments other than the FGSs, including the Faint Object Camera (FOC; Barbieri et al. 1996A&A...315..418B), the Faint Object Spectrograph (FOS; Schultz et al. 1998PASP..110...31S), the Near-Infrared Camera and Multi-Object Spectrometer (NICMOS; Golimowski et al. 2004AJ....128.1733G), and the Wide-Field Planetary Camera 2 (WFPC2; Schroeder et al. 2000AJ....119..906S; Dieterich et al. 2012, Cat. J/AJ/144/64). Our radial velocity measurements, listed in table3, are from two sources. We obtained most radial velocity data with the McDonald 2.1m Struve telescope and the Sandiford Cassegrain Echelle spectrograph, hereafter CE. The CE delivers a dispersion equivalent to 2.5km/s/pix (R=λ/Δλ=60000) with a wavelength range of 5500{<=}λ{<=}6700Å spread across 26 orders (apertures). The McDonald data were collected during 33 observing runs from 1995 to 2009. Some GJ 623 AB velocities came from the Hobby-Eberly Telescope (HET) using the Tull Spectrograph. (3 data files).

Efficacy and safety evaluation of pentoxifylline associated with other antioxidants in medical treatment of Peyronie's disease: a case-control study

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Paulis G

2015-12-01

Full Text Available Gianni Paulis,1,2 Davide Barletta,3 Paolo Turchi,4 Antonio Vitarelli,5 Giuseppe Dachille,6 Andrea Fabiani,7 Romano Gennaro8 1Regina Apostolorum Hospital, Andrology Center, Albano L, 2Castelfidardo Medical Team, Peyronie's Disease Care Center, Rome, 3Department of Urology, Andrology Center, San Matteo Hospital, Pavia, 4Azienda ASL 4 Prato – Andrology Service, Prato, 5Department of Urology, University of Bari, 6Department of Urology, S Giacomo Hospital, Monopoli, Bari, 7Department of Surgery, Section of Urology and Andrology, Macerata, 8Department of Urologic Oncology, Section of Avellino, Italian League Against Cancer, Avellino, Italy Abstract: Peyronie's disease (PD is a chronic disorder involving the tunica albuginea surrounding the corpora cavernosa of the penis. A conservative treatment is indicated in the first stage of disease. The aim of this study was to assess the therapeutic impact and possible side effects of treatment with pentoxifylline (PTX in combination with other antioxidants in 307 patients with early-stage PD. Patients were subdivided into three groups: A, B, and C. Both groups, A and B, comprising of 206 patients, underwent treatment, whereas Group C was the control group (n=101. Treatment lasted 6 months and included the following: Group A: PTX 400 mg twice a day + propolis 600 mg/d + blueberry 160 mg/d + vitamin E 600 mg/d + diclofenac 4% gel twice/a day + PTX 100 mg via perilesional penile injection/every other week (12 injections in all; Group B: the same treatment as Group A except for the penile PTX injections. After the 6-month treatment course, we obtained the following results: actual mean decrease in plaque volume -46.9% and -24.8% in Group A and B, respectively (P<0.0001; mean curvature reduction -10.1° and -4.8°, respectively (P<0.0001; resolution of pain in 67.6% and 67.2% of cases, respectively (P=0.961; recovery of normal penile rigidity in 56.09% and 23.5% of cases, respectively (P=0.005. After 6 months

L’inscrutabile voce della triade. I tintinnabuli di Arvo Pärt tra filosofia e liturgia

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Marcello La Matina

2011-01-01

Full Text Available Può il brusio di una voce essere anche il luogo di una lingua? E vale questa topica anche nel caso in cui la voce sia quella di uno strumento musicale? Queste domande sono alla base della indagine sulla tecnica compositiva della tintinnabulatio, inventata e sperimentata dal musicista estone Arvo Pärt (Paide, 1935. I tintinnabuli consistono di due elementi apparentemente contraddittori: la sonorità pastosa dello zvod (le campane della liturgia ortodossa russa e l’armonia della triade perfetta. Muovendo da un disco ricevuto in dono e dalla interpretazione in parte inedita di un passo di san Paolo, l’autore cerca di individuare il punto di articolazione dei tintinnabuli,  quella “grana” dove – come disse una volta Roland Barthes – una lingua incontra una voce. Il problema musicale sottende le interminabili discussioni trinitarie dell’Oriente cristiano  – qui per sfortuna solo accennate – e si manifesta nella figura dell’iconografo medievale Andrej Rublëv, cui il regista russo Tarkovskij ha dedicato, nel 1966, un denso e ispiratissimo film.   Could the rustling of a voice be also the place of a language?  And does it happen all the same, when the voice at issue is that of an instrumental body? Such questions are the basic ones for any inquiry into Arvo Pärt’s tintinnabuli—the technique invented and experienced by the famous Esthonian composer ( born in Paide, the 1935. It consists of  two seemingly conflicting elements: the doughy resonance of the zvot (i.e. the Russian liturgical set of bells; and the harmony of the perfect triad. The present paper moves from the personal memory of listening Pärt’s elegy Silouans Song. The delicate instrumental piece is said to conceal a prosodical calque of the voice of the famous staretz Silouan the Athonite (1866-1938. Silouan’s song —to use Barthes’ words—is the very place where “a language does meet a voice”.  Some interpretive consequences lead off such a

Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers

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Cossu MV

2014-05-01

Full Text Available Maria Vittoria Cossu,1 Dario Cattaneo,1 Serena Fucile,1 Paolo Pellegrino,1 Sara Baldelli,1 Valeria Cozzi,1 Amedeo Capetti,2 Emilio Clementi1,3 1Unit of Clinical Pharmacology, Consiglio Nazionale delle Ricerche Institute of Neuroscience, Department of Biomedical and Clinical Sciences, University Hospital “Luigi Sacco”, Università di Milano, Milan, Italy; 2Unit of Infectious Diseases, University Hospital “Luigi Sacco”, Milan, Italy; 3Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Lecco, Italy Abstract: We designed two Phase I studies that assessed healthy volunteers in order to evaluate the safety and to optimize the dosing of the combination of the drugs isosorbide dinitrate, a nitric oxide donor, and ibuprofen, a nonsteroidal antiinflammatory drug. We designed these studies with the aim of designing a Phase II trial to evaluate the drugs’ efficacy in patients affected by Duchenne muscular dystrophy. For the first trial, ISOFEN1, a single-dose, randomized-sequence, open-label, active control, three-treatment cross-over study, was aimed at comparing the pharmacokinetics of ibuprofen 200 mg and isosorbide dinitrate 20 mg when given alone and concomitantly. The pharmacokinetics of ibuprofen given alone versus ibuprofen given concomitantly with isosorbide dinitrate were similar, as documented by the lack of statistically significant differences in the main drug’s pharmacokinetic parameters (time to maximal concentration [Tmax], maximal concentration [Cmax], area under the curve [AUC]0–t, and AUC0–∞. Similarly, we found that the coadministration of ibuprofen did not significantly affect the pharmacokinetics of isosorbide dinitrate. No issues of safety were detected. The second trial, ISOFEN2, was a single-site, dose titration study that was designed to select the maximum tolerated dose for isosorbide dinitrate when coadministered with ibuprofen. Eighteen out of the 19 enrolled subjects tolerated the treatment well, and

Geodiversity and geohazards of the Susa Valley (W-Alps, Italy): combining scientific research and new technologies for enhanced knowledge and proactive management of geoheritage in mountain regions

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Giardino, Marco; Bacenetti, Marco; Perotti, Luigi; Giordano, Enrico; Ghiraldi, Luca; Palomba, Mauro

2013-04-01

Mountain regions have a range of geological and geomorphological features that make them very attractive for tourism activities. As a consequence, increased human "pressure" causes impacts on geoheritage sites and higher geomorphological risks. These effects are magnified by active geomorphic processes characterizing mountains areas, highly sensitive to climate change. In term of "human sensitivity", several sociological surveys have shown that "perceived risk", not "real risk", influences people's behavior towards natural hazards. The same approach can be applied to geodiversity and geoheritage. Based on these assumptions, we considered the possible strategic roles played by diffusion of scientific research and application of new technologies: 1) to enhance awareness, either of geodiversity or environmental dynamics and 2) to improve knowledge, both on geoheritage management and natural risk reduction. Within the activities of the "ProGEO-Piemonte Project" (Progetti d'Ateneo 2011, cofunded by Universita? degli Studi di Torino and Compagnia di San Paolo Bank Foundation), we performed a systematic review of geodiversity and natural hazards information in the Piemonte Region (NW-Italy). Then we focused our attention on the Susa Valley, an area of the Western Alps where the geoheritage is affected by very active morphodynamics, as well as by a growing tourism, after the 2006 winter Olympics. The Susa Valley became one of the 9 strategic geothematic areas have been selected to represent the geodiversity of the Piemonte region, each characterized by high potential for enhancement of public understanding of science, and recreation activities supported by local communities. Then we contributed to the awareness-raising communication strategy of the "RiskNat project" (Interreg Alcotra 2007-2013, Action A.4.3) by synthesizing geoscience knowledge on the Susa Valley and information on slope instabilities and models/prevention measures/warning systems. Visual representations

Introduction and Committees

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Angelova, Maia; Zakrzewski, Wojciech; Hussin, Véronique; Piette, Bernard

2011-03-01

This volume contains contributions to the XXVIIIth International Colloquium on Group-Theoretical Methods in Physics, the GROUP 28 conference, which took place in Newcastle upon Tyne from 26-30 July 2010. All plenary and contributed papers have undergone an independent review; as a result of this review and the decisions of the Editorial Board most but not all of the contributions were accepted. The volume is organised as follows: it starts with notes in memory of Marcos Moshinsky, followed by contributions related to the Wigner Medal and Hermann Weyl prize. Then the invited talks at the plenary sessions and the public lecture are published followed by contributions in the parallel and poster sessions in alphabetical order. The Editors:Maia Angelova, Wojciech Zakrzewski, Véronique Hussin and Bernard Piette International Advisory Committee Michael BaakeUniversity of Bielefeld, Germany Gerald DunneUniversity of Connecticut, USA J F (Frank) GomesUNESP, Sao Paolo, Brazil Peter HanggiUniversity of Augsburg, Germany Jeffrey C LagariasUniversity of Michigan, USA Michael MackeyMcGill University, Canada Nicholas MantonCambridge University, UK Alexei MorozovITEP, Moscow, Russia Valery RubakovINR, Moscow, Russia Barry SandersUniversity of Calgary, Canada Allan SolomonOpen University, Milton Keynes, UK Christoph SchweigertUniversity of Hamburg, Germany Standing Committee Twareque AliConcordia University, Canada Luis BoyaSalamanca University, Spain Enrico CeleghiniFirenze University, Italy Vladimir DobrevBulgarian Academy of Sciences, Bulgaria Heinz-Dietrich DoebnerHonorary Member, Clausthal University, Germany Jean-Pierre GazeauChairman, Paris Diderot University, France Mo-Lin GeNankai University. China Gerald GoldinRutgers University, USA Francesco IachelloYale University, USA Joris Van der JeugtGhent University, Belgium Richard KernerPierre et Marie Curie University, France Piotr KielanowskiCINVESTAV, Mexico Alan KosteleckyIndiana University, USA Mariano del Olmo

Multicomponent, peptide-targeted glycol chitosan nanoparticles containing ferrimagnetic iron oxide nanocubes for bladder cancer multimodal imaging

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Key J

2016-08-01

Full Text Available Jaehong Key,1,2 Deepika Dhawan,3 Christy L Cooper,3,4 Deborah W Knapp,3 Kwangmeyung Kim,5 Ick Chan Kwon,5 Kuiwon Choi,5 Kinam Park,1,6 Paolo Decuzzi,7–9 James F Leary1,3,41Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA; 2Department of Biomedical Engineering, Yonsei University, Wonju, Republic of Korea; 3School of Veterinary Medicine-Department of Basic Medical Sciences, Purdue University, West Lafayette, 4Birck Nanotechnology Center at Discovery Park, Purdue University, West Lafayette, IN, USA; 5Biomedical Research Center, Korea Institute of Science and Technology, Sungbook-Gu, Seoul, Republic of Korea; 6Department of Pharmaceutics, Purdue University, West Lafayette, IN, 7Department of Translational Imaging, 8Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX USA; 9Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia (IIT, Genova, Italy Abstract: While current imaging modalities, such as magnetic resonance imaging (MRI, computed tomography, and positron emission tomography, play an important role in detecting tumors in the body, no single-modality imaging possesses all the functions needed for a complete diagnostic imaging, such as spatial resolution, signal sensitivity, and tissue penetration depth. For this reason, multimodal imaging strategies have become promising tools for advanced biomedical research and cancer diagnostics and therapeutics. In designing multimodal nanoparticles, the physicochemical properties of the nanoparticles should be engineered so that they successfully accumulate at the tumor site and minimize nonspecific uptake by other organs. Finely altering the nano-scale properties can dramatically change the biodistribution and tumor accumulation of nanoparticles in the body. In this study, we engineered multimodal nanoparticles for both MRI, by using ferrimagnetic nanocubes (NCs, and near infrared fluorescence imaging

One-pill once-a-day HAART: a simplification strategy that improves adherence and quality of life of HIV-infected subjects

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Monica Airoldi

2010-05-01

Full Text Available Monica Airoldi1,6, Mauro Zaccarelli2, Luca Bisi3, Teresa Bini4, Andrea Antinori2, Cristina Mussini3, Francesca Bai4, Giancarlo Orofino5, Laura Sighinolfi7, Andrea Gori6, Fredy Suter1, Franco Maggiolo11Division of Infectious Diseases, Ospedali Riuniti, Bergamo; 2Clinical Department, INMI L Spallanzani, Roma; 3Division of Infectious Diseases, Università, Modena; 4Division of Infectious Diseases, Ospedale San Paolo, Milano; 5Division of Infectious Diseases, Ospedale Amedeo di Savoia, Torino; 6Division of Infectious Diseases, Ospedale San Gerardo, Monza; 7Division of Infectious Diseases, Ospedale Sant’Anna, Ferrara, ItalyObjective: The aim of the ADONE (ADherence to ONE pill study was to verify the effect of a reduced number of pills on adherence and quality of life (QoL in HIV-infected patients on highly active antiretroviral therapy (HAART.Design: Prospective, multicenter, study.Methods: Patients chronically treated with emtricitabine (FTC + tenofovir (TDF + efavirenz (EFV or lamivudine (3TC + TDF + EFV and with a HIV-RNA < 50 copies/mL were switched to the single-pill fixed-dose regimen (FDR of FTC + TDF + EFV. Data were collected with SF-36 using visual analog scales. Results of the final (6 months primary as-treated analysis are reported.Results: 212 patients (77.4% males of mean age 45.8 years were enrolled; 202 completed the study. One month post switch to FDR the adherence rate increased significantly to 96.1% from a baseline value of 93.8% (P < 0.01. The increase was steadily maintained throughout the study (96.2% at 6 months. QoL improved over time from 68.8% to 72.7% (P = 0.042 as well, and was significantly associated with the perception of health status, presence of adverse events (AEs and number of reported AEs (P < 0.0001. QoL significantly influenced adherence (P < 0.0001. During FDR use the mean CD4 count increased from 556 to 605 cells/μL (P < 0.0001. At the end of follow-up 98% of patients maintained HIV-RNA level < 50 copies

Segnalazioni/Informes/Rapports/Reports

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Emanuele Monegato

2013-12-01

Full Text Available di Elisa Cairati, Paolo Caponi, Emanuele Monegato, Anna Pasolini   Amy Stewart, Wicked Plants, London, Timber Press, 2010, 236 pp. ISBN 978-160-469-127-6 Andrea Corrado e Igor Mariottini, Cinema e autori sulle tracce delle migrazioni, Roma, Ediesse, 2013, 155 pp. ISBN 978-882-301-625-5 Carlos Busqued, Sotto questo sole tremendo, Roma, Atmosphere libri, 2012, 141 pp. ISBN 978-88-6564-032-6 Doménico Chiappe, Tan real como la ficción (Herramientas narrativas en periodismo, Barcelona, Editorial Laertes, 2010, 197 pp. ISBN 978-84-7584-704-7 Eduardo Huarag Álvarez, La cultura oral en la narrativa hispanoamericana, Lima, Editorial San Marcos, 2011, 293 pp. ISBN 978-612-302-537-3 Eduardo L. Holmberg, Le ossa, Salerno, Edizioni Arcoiris, 2012, 114 pp. ISBN 978-88-96583-28-9 Guido Bonsaver, Mussolini censore. Storie di letteratura, dissenso e ipocrisia, Bari, Laterza, 2013, 230 pp. ISBN 9788858106624 Leila Guerriero, Frutos extraños (crónicas reunidas 2001-2008, Madrid, Alfaguara, 2009, 400 pp. ISBN 978-84-204-0371-7 Marco Di Domenico, Italiani Pericolosi, Torino, Bollati Boringhieri, 2012, 254 pp. ISBN 978-883-392-335-2 Margo Lanagan, Tender Morsels, New York, Alfred A. Knopf, 2008, 464 pp. ISBN 978-0-375-84305-1 María Caballero Wangüemert, Las trampas de la emancipación. Literatura femenina y mundo hispánico, Madrid, Biblioteca Nueva/Minerva, 2012, 363 pp. ISBN 978-84-9940-529-2 Maria Cristina Paganoni, Representing the City. Linguistic Perspectives,Discursive Strategies and Multimodality in City Branding, Bergamo, Lubrina Editore, 2012, 148 pp. ISBN 978 88 7766 464 8 Michael Denning, Cover Stories. Narrative and Ideology in the British Spy Thriller, London, Routledge, 1987, 168 pp. ISBN 0-7100-9642-9; John G. Cawelti, Bruce A. Rosenberg, The Spy Story, Chicago and London, The University of Chicago Press, 1987, 270 pp. ISBN 0-226- 09868-0 Nicoletta Vallorani, Millennium London. Of Other Spaces and the Metropolis, Milano/Udine, Mimesis, 2012

Behavioral and clinical characteristics of people receiving medical care for HIV infection in an outpatient facility in Sicily, Italy

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Di Carlo P

2016-05-01

Full Text Available Paola Di Carlo,1 Giuliana Guadagnino,1 Palmira Immordino,1 Giovanni Mazzola,2 Pietro Colletti,2 Ilenia Alongi,1 Lucia Adamoli,1 Francesco Vitale,1 Alessandra Casuccio1 1Department of Sciences for Health Promotion and Mother-Child Care “G D’Alessandro”, University of Palermo, 2Department of Medicinal Clinics and Emerging Diseases, “Paolo Giaccone” Polyclinic University Hospital, Palermo, Italy Aim: The authors examined a cohort of HIV-positive outpatients at the AIDS Center of Palermo University in Italy in order to identify factors related to the frequency of their visits to the outpatient facility for health care services.Methods: Two hundred and twenty-four HIV-infected subjects were enrolled in the study. Demographic and HIV disease characteristics were recorded and assessed with the number of days accessed to our outpatients unit in univariate and multivariate analyses. The potential relationship with immunological status was also analyzed stratifying the patients into groups according to their CD4+ T-cell counts (≥500 vs <500/mm3, and ≥200 vs <200/mm3.Results: Both univariate and multivariate analyses showed that duration of antiretroviral therapy <5 years and hypertension were significantly associated with a CD4+ T-cell count of <500/mm3, whereas geographic origin (Africa was associated with a CD4+ T-cell count of <200/mm3. Mean number of days the patients sought access to day-care services for laboratory tests was negatively associated with CD4+ T-cell count.Conclusion: Patients with low CD4+ T-cell counts showed higher use of health care services, demonstrating how early HIV diagnosis can help to reduce health care costs. The CD4+ T-cell cut-off of 200 cells emphasizes the importance of identifying and managing HIV infection among hard-to-reach groups like vulnerable migrants. In our sample, the illegal status of immigrants does not influence the management of their HIV/AIDS condition, but the lack of European health card

Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE--5-a population-based study.

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De Angelis, Roberta; Sant, Milena; Coleman, Michel P; Francisci, Silvia; Baili, Paolo; Pierannunzio, Daniela; Trama, Annalisa; Visser, Otto; Brenner, Hermann; Ardanaz, Eva; Bielska-Lasota, Magdalena; Engholm, Gerda; Nennecke, Alice; Siesling, Sabine; Berrino, Franco; Capocaccia, Riccardo

2014-01-01

to different degrees depending on region and cancer type. The major advances in cancer management that occurred up to 2007 seem to have resulted in improved survival in Europe. Likely explanations of differences in survival between countries include: differences in stage at diagnosis and accessibility to good care, different diagnostic intensity and screening approaches, and differences in cancer biology. Variations in socioeconomic, lifestyle, and general health between populations might also have a role. Further studies are needed to fully interpret these findings and how to remedy disparities. Italian Ministry of Health, European Commission, Compagnia di San Paolo Foundation, Cariplo Foundation. Copyright © 2014 Elsevier Ltd. All rights reserved.

Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy

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Miele E

2012-07-01

Full Text Available Evelina Miele,1,* Gian Paolo Spinelli,2,* Ermanno Miele,3 Enzo Di Fabrizio,3,6 Elisabetta Ferretti,4 Silverio Tomao,2 Alberto Gulino,1,5 1Department of Molecular Medicine, 2Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, 3Nanostructures, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genova, 4Department of Experimental Medicine, Sapienza University of Rome, Rome, 5Center for Life Nanoscience, Istituto Italiano di Tecnologia, Rome, Italy, 6BIONEM lab, University of Magna Graecia, Campus S. Venuta, Viale Europa 88100 Catanzaro, Italy *These authors contributed equally to this workAbstract: During recent decades there have been remarkable advances and profound changes in cancer therapy. Many therapeutic strategies learned at the bench, including monoclonal antibodies and small molecule inhibitors, have been used at the bedside, leading to important successes. One of the most important advances in biology has been the discovery that small interfering RNA (siRNA is able to regulate the expression of genes, by a phenomenon known as RNA interference (RNAi. RNAi is one of the most rapidly growing fields of research in biology and therapeutics. Much research effort has gone into the application of this new discovery in the treatment of various diseases, including cancer. However, even though these molecules may have potential and strong utility, some limitations make their clinical application difficult, including delivery problems, side effects due to off-target actions, disturbance of physiological functions of the cellular machinery involved in gene silencing, and induction of the innate immune response. Many researchers have attempted to overcome these limitations and to improve the safety of potential RNAi-based therapeutics. Nanoparticles, which are nanostructured entities with tunable size, shape, and surface, as well as biological behavior, provide an ideal opportunity to modify current

Cost-effectiveness analysis of dolutegravir plus backbone compared with raltegravir plus backbone, darunavir+ritonavir plus backbone and efavirenz/tenofovir/emtricitabine in treatment naïve and experienced HIV-positive patients

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Restelli U

2017-06-01

Full Text Available Umberto Restelli,1,2 Giuliano Rizzardini,3,4 Andrea Antinori,5 Adriano Lazzarin,6 Marzia Bonfanti,1 Paolo Bonfanti,7 Davide Croce1,2 1Centre for Research on Health Economics, Social and Health Care Management, LIUC – Università Cattaneo, Castellanza, Varese, Italy; 2School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 3First and Second Divisions of Infectious Diseases, “Luigi Sacco” Hospital, Milan, Italy; 4School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 5National Institute for Infectious Diseases “L Spallanzani”, Rome, 6Department of Infectious Diseases, San Raffaele Scientific Institute, 7Department of Infectious and Tropical Diseases, A Manzoni Hospital, Lecco, Italy Background: In January 2014, the European Medicines Agency issued a marketing authorization for dolutegravir (DTG, a second-generation integrase strand transfer inhibitor for HIV treatment. The study aimed at determining the incremental cost-effectiveness ratio (ICER of the use of DTG+backbone compared with raltegravir (RAL+backbone, darunavir (DRV+ritonavir(r+backbone and efavirenz/tenofovir/emtricitabine (EFV/TDF/FTC in HIV-positive treatment-naïve patients and compared with RAL+backbone in treatment-experienced patients, from the Italian National Health Service’s point of view.Materials and methods: A published Monte Carlo Individual Simulation Model (ARAMIS-DTG model was used to perform the analysis. Patients pass through mutually exclusive health states (defined in terms of diagnosis of HIV with or without opportunistic infections [OIs] and cardiovascular disease [CVD] and successive lines of therapy. The model considers costs (2014 and quality of life per monthly cycle in a lifetime horizon. Costs and quality-adjusted life years (QALYs are dependent on OI, CVD, AIDS events, adverse events and antiretroviral therapies.Results: In

Mapracorat, a selective glucocorticoid receptor agonist, causes apoptosis of eosinophils infiltrating the conjunctiva in late-phase experimental ocular allergy

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Baiula M

2014-06-01

Full Text Available Monica Baiula,1 Andrea Bedini,1 Jacopo Baldi,1 Megan E Cavet,2 Paolo Govoni,3 Santi Spampinato11Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy; 2Global Pharmaceutical R&D, Bausch & Lomb Inc., Rochester, NY, USA; 3Department of Biomedical, Biotechnological and Translational Sciences, University of Parma, Parma, ItalyBackground: Mapracorat, a novel nonsteroidal selective glucocorticoid receptor agonist, has been proposed for the topical treatment of inflammatory disorders as it binds with high affinity and selectivity to the human glucocorticoid receptor and displays a potent anti-inflammatory activity, but seems to be less effective in transactivation of a number of genes, resulting in a lower potential for side effects. Contrary to classical glucocorticoids, mapracorat displays a reduced ability to increase intraocular pressure and in inducing myocilin, a protein linked to intraocular pressure elevation. Allergic conjunctivitis is the most common form of ocular allergy and can be divided into an early phase, developing immediately after allergen exposure and driven primarily by mast cell degranulation, and a late phase, developing from 6–10 hours after the antigen challenge, and characterized by conjunctival infiltration of eosinophils and other immune cells as well as by the production of cytokines and chemokines.Methods: In this study, mapracorat was administered into the conjunctival sac of ovalbumin (OVA-sensitized guinea pigs 2 hours after the induction of allergic conjunctivitis, with the aim of investigating its activity in reducing clinical signs of the late-phase ocular reaction and to determine its mechanism of anti-allergic effects with respect to apoptosis of conjunctival eosinophils and expression of the chemokines C-C motif ligand 5 (CCL5, C-C motif ligand 11 (CCL11, and interleukin-8 (IL-8 and the proinflammatory cytokines interleukin-1β (IL-1β and tumor necrosis factor-α (TNF

Seis poemas inéditos

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Alda Merini

2014-07-01

Full Text Available Alda Merini nace en Milán el 21 de marzo de 1931, y comienza a escribir muy pronto. Gracias al aprecio de amigos y escritores -entre los cuales se hallaban Giorgio Manganelli, David Maria Turoldo, Maria Corti, Luciano Erba-, algunos de sus poemas aparecen en Antología de la poesía italiana 1909-1949, al cuidado de Giacinto Spagnoletti, publicada en 1950. Otros poemas se incluyeron en el libro Poetisas del siglo xx (1951, a cargo de Giovanni Sheiwiller. Su primer libro publicado es La presencia de Orfeo (1953, bien acogido por los mejores exponentes de la poesía italiana, como Quasimodo, Montale, Pasolini... A este seguirán los volúmenes: Miedo de Dios y Nupcias romanas, ambos publicados en 1955. Merini contrae matrimonio con Ettore Carniti en 1953. Durante los años siguientes nacerán dos de sus hijas. En 1961 se publica Tú eres Pedro, obra que cierra el primer período de su producción poética. Seguirá un largo intervalo marcado por un debilitamiento emocional que llevará a Alda Merini, de 1965 a 1972, a someterse a largos períodos de internamiento en el Instituto Psiquiátrico Paolo Pini. Nacerán durante estos años dos hijas más. En el hospital escribe esporádicamente por recomendación de los médicos; pero a partir de 1979 inicia una nueva etapa creativa: la reflexión sobre la devastadora experiencia en el manicomio hace nacer los poemas que sólo verán la luz en 1984, cuando Scheiwiller los da a conocer bajo el título La Tierra Santa, obra maestra que en 1993 obtendrá el Premio Librex Montale. [...] Los poemas que ahora presentamos, inéditos hasta el momento en castellano, pertenecen a uno de sus últimos poemarios, Padre mio (Frassinelli, 2009, y pueden considerarse un avance de la traducción que publicará el próximo otoño la editorial Vaso Roto de manos de la traductora Jeannette Lozano Clariond. A esta traductora, gran conocedora de la obra de Alda Merini, se deben también las ediciones de títulos como

Identity development, intelligence structure, and interests: a cross-sectional study in a group of Italian adolescents during the decision-making process

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Pellerone M

2015-08-01

Full Text Available Monica Pellerone,1 Alessia Passanisi,1 Mario Filippo Paolo Bellomo2 1Faculty of Human and Social Science, “Kore” University of Enna, Enna, 2Credito Emiliano Bank, Piazza Armerina, Italy Background: Forming one’s identity is thought to be the key developmental task of adolescence, but profound changes in personality traits also occur in this period. The negotiation of complex social settings, the creation of an integrated identity, and career choice are major tasks of adolescence. The adolescent, having to make choices for his or her future, has not only to consider his or her own aspirations and interests but also to possess a capacity for exploration and commitment; in fact, career commitments can be considered as a fit between the study or career that is chosen and personal values, skills, and preferences. Methods: The objective of the study reported here was to investigate the role of identity on profile of interests; the relation between identity and decisional style; the correlation between identity, aptitudes, interests, and school performance; and the predictive variables to school success. The research involved 417 Italian students who live in Enna, a small city located in Sicily, Italy, aged 16–19 years (197 males and 220 females in the fourth year (mean =17.2, standard deviation =0.52 and the fifth year (mean =18.2, standard deviation =0.64 of senior secondary school. The research lasted for one school year; the general group of participants consisted of 470 students, and although all participants agreed to be part of the research, there was a dropout rate of 11.28%. They completed the Ego Identity Process Questionnaire to measure their identity development, the Intelligence Structure Test to investigate aptitudes, the Self-Directed Search to value interests, and General Decision Making Style questionnaire to describe their individual decisional style. Results: The data showed that high-school performance was positively

Soil Organic Carbon (SOC) distribution in two differents soil types (Podzol and Andosol) under natural forest cover.

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Álvarez-Romero, Marta; Papa, Stefania; Verstraeten, Arne; Cools, Nathalie; Lozano-García, Beatriz; Parras-Alcántara, Luis; Coppola, Elio

2017-04-01

Andosols are young soils that shall know a successive evolution towards pedological types where the dominant pedogenetic processes are more evident. Vegetation and climate influence Andosols evolution to other order of soils. In cold and wet climates or on acid vulcanite under heavy leaching young Andosols could change into Podzols (Van Breemn and Buurman, 1998). Were investigated a Podzol soil (World References Base, 2014) at Zoniën (Belgium), were and an Andosol soil (World References Base, 2014) at Lago Laceno (Avellino, Italy). This study shows the data on the SOC (Soil Organic Carbon) fractionation in two profiles from two natural pine forest soils. Together with the conventional activities of sampling and analysis of soil profile were examined surveys meant to fractionation and characterization of SOC, in particular: Total Organic Carbon (TOC) and Total Extractable Carbon (TEC) soil contents were determined by Italian official method of soil analysis (Mi.P.A.F. (2000)). Different soil C fractions were also determined: Humic Acid Carbon (HAC), Fulvic Acid Carbon (FAC), Not Humic Carbon (NHC) and Humin Carbon (Huc) fractions were obtained by difference. In the whole profile, therefore, were also assayed cellulose and lignin contents. The aim of this work was to compare the distribution of different soil organic components in a podzol and a soil with andic properties. The data show great similarity, among the selected profiles, in the organic components distribution estudied. References: - Mi.P.A.F. - Ministero per le Politiche Agricole e Forestali - Osservatorio Nazionale Pedologico e per la Qualità del Suolo (2000): Metodi Ufficiali di Analisi Chimica del Suolo. In: Franco Angeli (Editor), Collana di metodi analitici per l'agricoltura diretta da Paolo Sequi, n. 1124.2, Milano, Italy. - Van Breemn N. and Buurman P. (1998) Chapter 12 Formation of Andisols. In: Soil formation. Kluwer Ed., Wageningen, The Netherlands, 271-289. -Ussiri D.A.N., Johnson C

International symposium on utilization of accelerators. Proceedings

International Nuclear Information System (INIS)

2003-01-01

fluorescence microprobe techniques can be used to explore the trace element content of medical, environmental and historical samples. Synchrotron light may also be applied using photolithographic techniques to manufacture mechanical parts down to sizes in the range of hundredths of a millimeter ( n anotechnology ) . This five day symposium was attended by 137 delegates from 35 countries and was hosted by the Government of Brazil through its Instituto de Pesquisas Energeticas e Nucleares (IPEN) in Sao Paolo. Overall, 61 papers, including 9 invited papers, and 22 poster papers were presented. The main objectives of the symposium were to bring together scientists to exchange information and review the status of current accelerator developments and applications, to discuss new trends and technologies and to promote research collaborations between laboratories in IAEA Member States

The CMS team celebrates the arrival of the "Tube". From left to right, sitting: Blanca Perea Solano, Jeannine Muffat-Joly, Ariella Cattai (Tracker Technical Coordinator). Standing: Georges Roiron, Hans Postema, Eric Albert, Paolo Petagna, Arvid Larsson, Nuno Bernardino Rodrigues, Enzo Carrone, Jack Hill.

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Maximilien Brice

2004-01-01

CMS: Aerospace goes underground : gleaming aluminium on the outside and carbon black on the inside, as long as a sedan and taller than a man, a strange hollow cylinder arrived at CERN by truck August 26.

Structural setting of the Metán Basin (NW Argentina): new insights from 2D seismic profiles

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Conti, Alessia; Maffucci, Roberta; Bigi, Sabina; Corrado, Sveva; Giordano, Guido; Viramonte, José G.

2017-04-01

Structural Geology, 33, 1816-1828. Kley, J., Monaldi, C. R. & Salfity, J. A., 1999. Along strike segmentation of the Andean foreland: causes and consequences. Tectonophysics, 301, 75-94. Maffucci, R., Bigi, S., Corrado, S., Chiodi, A., Di Paolo, L., Giordano, G., Invernizzi, C., 2015. Quality assessment of reservoirs by means of outcrop data and "discrete fracture network" models: The case history of Rosario de La Frontera (NW Argentina) geothermal system. Tectonophysics, 647, 112-131. Salfity, J.A., Marquillas, R.A., 1981. Las unidades estratigráficas cretácicas del Norte de Argentina. In: Volkheimer, W., Musacchio, E. (Eds.), Cuencas Sedimentarias del Jurásico y Cretácico de América del Sur, 1, 303-317.

Twenty-four-week effects of liraglutide on body composition, adherence to appetite, and lipid profile in overweight and obese patients with type 2 diabetes mellitus

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Rondanelli M

2016-03-01

Full Text Available Mariangela Rondanelli,1 Simone Perna,1 Paolo Astrone,2 Annalisa Grugnetti,2 Sebastiano Bruno Solerte,2 Davide Guido3,4 1Endocrinology and Nutrition Unit, Section of Human Nutrition, Department of Public Health, Experimental and Forensic Medicine, Agency for Elderly People Services, Santa Margherita Hospital, University of Pavia, Pavia, Italy; 2Section of Geriatrics and Gerontology, Department of Internal Medicine, Agency for Elderly People Services, Santa Margherita Hospital, University of Pavia, Pavia, Italy; 3Medical and Genomics Statistics Unit, Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; 4Biostatistics and Clinical Epidemiology Unit, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy Background: Liraglutide has well-known effects on glucose patterns. However, its several other metabolic properties are still controversial. Given this background, the aims of the present study are to evaluate the effects of 24-week liraglutide treatment on body composition, appetite, and lipid profile in overweight and obese type 2 diabetes mellitus (T2DM patients. Methods: A cohort study was carried out on overweight and obese T2DM patients with glycosylated hemoglobin A1c equal to 6% (42 mmol/mol-10% (86 mmol/mol, under a 3-month treatment (at least with maximal dose of metformin as stable regime, by adding liraglutide at doses up to 3 mg/d. Body composition markers were measured by dual-energy X-ray densitometry at baseline and after 24 weeks of liraglutide treatment. Glucose control was monitored by glucose, glycosylated hemoglobin A1c, insulin, and homeostasis model assessment. Finally, the appetite sensation and plasma lipids were also evaluated. Results: Twenty-eight subjects (male/female: 16/12, mean age: 58.75±9.33 years, body mass index: 34.13±5.46 kg/m2 were evaluated. Accounting for the adjustment for age, sex, and duration of diabetes, we noted significant

Efficacy and safety of 0.5% levobupivacaine versus 0.5% bupivacaine for peribulbar anesthesia

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Pacella E

2013-05-01

Full Text Available Elena Pacella,1 Fernanda Pacella,1 Fabiana Troisi,2 Domenico Dell'Edera,3 Paolo Tuchetti,4 Tommaso Lenzi,1 Saul Collini21Department of Sense Organs, Faculty of Medicine and Dentistry, Rome, 2Department of Medical Surgical Sciences and Translational Medicine Sapienza, Faculty of Medicine and Psychology, Roma, University of Rome, Rome, 3Unit of Cytogenetic and Molecular Genetics, Madonna delle Grazie Hospital, Matera, 4National Institute for Health, Migration and Poverty, Rome, ItalyBackground: This randomized double-blind study examined the use of a new anesthetic agent, levobupivacaine 0.5%, which is the S(−-enantiomer of a racemic mixture of bupivacaine, for peribulbar anesthesia and compared it with racemic bupivacaine 0.5% alone or in combination with hyaluronidase 10 IU/mL.Methods: A total of 160 patients undergoing ophthalmic surgery were randomized into four groups (n = 40 each to receive inferotemporal peribulbar injection of levobupivacaine 0.5% (group L, racemic bupivacaine 0.5% (group B, levobupivacaine + hyaluronidase 10 IU/mL (group LH, or racemic bupivacaine + hyaluronidase 10 IU/mL (group BH by two anesthetists and two ophthalmologists in a ratio of 25% each. Ocular akinesia and orbicularis oculi function were evaluated using a three-point scale; a value < 5 points was considered as requiring surgery, and movements were re-evaluated the day following surgery to confirm regression of the block.Results: The time to onset (12 ± 2.6 minutes versus 13 ± 2.8 minutes and duration of anesthesia (185 ± 33.2 minutes versus 188 ± 35.7 minutes were similar between groups L and B. Complete akinesia (score 0 was obtained more frequently when hyaluronidase was used in addition to the anesthetic, with occurrences of 72.5% versus 57.5% in group LH versus L, respectively, and 67.5% versus 45% in group BH versus B. Moderate hypotension (<30% of baseline was observed in four patients (10% in group L, two (5.0% in group B, one (2.5% in group LH

Detecting Slow Deformation Signals Preceding Dynamic Failure: A New Strategy For The Mitigation Of Natural Hazards (SAFER)

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Vinciguerra, Sergio; Colombero, Chiara; Comina, Cesare; Ferrero, Anna Maria; Mandrone, Giuseppe; Umili, Gessica; Fiaschi, Andrea; Saccorotti, Gilberto

2015-04-01

Rock slope monitoring is a major aim in territorial risk assessment and mitigation. The high velocity that usually characterizes the failure phase of rock instabilities makes the traditional instruments based on slope deformation measurements not applicable for early warning systems. The use of "site specific" microseismic monitoring systems, with particular reference to potential destabilizing factors, such as rainfalls and temperature changes, can allow to detect pre-failure signals in unstable sectors within the rock mass and to predict the possible acceleration to the failure. We deployed a microseismic monitoring system in October 2013 developed by the University of Turin/Compagnia San Paolo and consisting of a network of 4 triaxial 4.5 Hz seismometers connected to a 12 channel data logger on an unstable patch of the Madonna del Sasso, Italian Western Alps. The initial characterization based on geomechanical and geophysical tests allowed to understand the instability mechanism and to design a 'large aperture' configuration which encompasses the entire unstable rock and can monitor subtle changes of the mechanical properties of the medium. Stability analysis showed that the stability of the slope is due to rock bridges. A continuous recording at 250 Hz sampling frequency (switched in March 2014 to 1 kHz for improving the first arrival time picking and obtain wider frequency content information) and a trigger recording based on a STA/LTA (Short Time Average over Long Time Average) detection algorithm have been used. More than 2000 events with different waveforms, duration and frequency content have been recorded between November 2013 and March 2014. By inspecting the acquired events we identified the key parameters for a reliable distinction among the nature of each signal, i.e. the signal shape in terms of amplitude, duration, kurtosis and the frequency content in terms of range of maximum frequency content, frequency distribution in spectrograms. Four main

Prefazione al volume 9 di Gerbertus in Transitu Mercurii

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Sigismondi, Costantino

2016-05-01

The papers published in this volume deal with historical and contemporary themes of physics and astronomy, always with the focus in didactics, as in the style of Gerbert of Aurillac, "rogatus a pluribus" (required by several students to write down the basics of new sciences). 1. Christopher Columbus in the voyage to America of 1492 discovered the deviation of the Magnetic North from the Celestial North; his measurements could have been done with the technology available to Gerbert, here we present the astronomical aspects of them. 2. On the meridian line of Santa Maria degli Angeli (1702) we repeated the experiences of Cassini in characterizing the refraction of the atmosphere by the difference between observed and calculated positions of the center of the Sun: 3. The collection of astronomical instruments in the Vatican Museums gives the opportunity to present the role of Astronomy in Catholic Church, starting from the calculation of Easter, present in the Chair of Hyppolitus. 4. The Eucharistic Miracle in Lanciano is dated VIII century AD, and the recognition of 1574 found the miracle of weights, where the five drops weigthed like one only. A discussion on that result is made on the light of sensibility of the scales of that time, which does not depart from the one of Gerbert's time. 5. The climate of X century allowed crossing the Alps: Luigi Mariani presents parallel evidences. 6. A list of 44 questions aswered by Paolo Rossi on modern physics/astrophysics is presented as a wish list of the level of culture of a secondary student. Three decades ago these topics were achievable only to University students: now are part of the public opinion, and a new framework has to be set by the teachers. 7. The dynamics of a micro-probe sent to alpha Centauri in 20 years is studied numerically. 8. The azimut of the Pyramid Cestia and 9. the height of the Vatican obelisk are studied exploiting solar ephemerides 10. The phases of pollen production of Cypress for 2016 are

Effect of indacaterol on lung deflation improves cardiac performance in hyperinflated COPD patients: an interventional, randomized, double-blind clinical trial

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Santus P

2015-09-01

Full Text Available Pierachille Santus,1,2 Dejan Radovanovic,1,2 Silvia Di Marco,3 Vincenzo Valenti,4,5 Rita Raccanelli,1,2 Francesco Blasi,6,7 Stefano Centanni,8,9 Maurizio Bussotti31Department of Health Sciences, University of Milan, 2Pulmonary Rehabilitation Unit, Fondazione Salvatore Maugeri Scientific Institute of Milan-IRCCS, 3Cardiological Rehabilitation Unit, Fondazione Salvatore Maugeri Rehabilitation Institute of Milan-IRCCS, 4Department of Biomedical Sciences for Health, University of Milan, 5Respiratory Unit, Policlinico San Donato-IRCCS, San Donato Milanese, 6Department of Pathophysiology and Transplantation, University of Milan, 7IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda Milan, 8Department of Health Sciences, University of Milan, 9Respiratory Unit, Ospedale San Paolo, Milan, ItalyBackground: COPD is often associated with cardiovascular comorbidity. Treatment guidelines recommend therapy with bronchodilators as first choice. We investigated the acute effect of single-dose indacaterol on lung hyperinflation in COPD subjects, for the first time evaluating the potential effects on right heart performance.Methods: In this Phase IV, randomized, interventional, double-blind, crossover clinical study, we recruited 40 patients (50–85 years of age with stable COPD. Patients were treated with 150 µg indacaterol or placebo and after 60 minutes (T60 and 180 minutes (T180 the following tests were performed: trans-thoracic echocardiography (TTE, plethysmography, diffusing capacity of the lung for carbon monoxide, saturation of peripheral oxygen, and visual analog scale dyspnea score. Patients underwent a crossover re-challenge after a further 72 hours of pharmacological washout. All TTE measurements were conducted blindly by the same operator and further interpreted by two different blinded operators. Consensus decisions were taken on every value and parameter. The primary outcome was the effect of the reduction of residual volume and functional

META-ANALISI E APPLICAZIONE DI UNA PROPOSTA DIDATTICA ORIENTATA ALL’AZIONE PER L’APPRENDIMENTO DEI SEGNALI DISCORSIVI IN ITALIANO LS

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Roberta Ferroni

2016-09-01

Full Text Available Nel presente contributo si riportano i risultati di uno studio i cui obiettivi sono: a verificare come vengono trattati i segnali discorsivi (SD in un manuale di italiano LS il cui approccio è orientato all’azione; b analizzare come questi SD vengono percepiti e ritualizzati nel parlato dialogico di studenti di italiano LS di livello B1 del Quadro comune europeo di riferimento per le lingue. La ricerca è stata svolta fra studenti universitari del corso di Laurea di Lingua e Letteratura Italiana della Facoltà di Filosofia, Lettere e Scienze Umane dell’Università di San Paolo del Brasile. Dall’analisi delle proposte didattiche, tratte dall’unità 6 del corso d’italiano per stranieri Bravissimo! 3-B1(Birello e Vilagrasa, 2014, si evince che le attività incentrate sui SD presuppongono un costante reimpiego in un contesto di lavoro significativo, attraverso degli «spazi interattivi» in cui gli apprendenti prendono consapevolezza e mettono alla prova le regole che gestiscono la co-costruzione conversazionale in LS. L’esposizione e la riflessione sui SD, abbinate a proposte di attività interattive significative, in cui lo studente ha un preciso scopo da raggiungere, offrono delle opportunità di riutilizzo dei SD simile a quello che può prodursi in una situazione al di fuori dell’aula. Meta-analysis and application for action-learning italian fl discourse signals In this paper we report the results of a study whose objectives were: a to determine how discourse markers (DMs are addressed in an action-oriented Italian FL textbooks; b to analyze how these DMs are perceived and ritualized in the spoken conversation of students studying Italian as a FL at the B1 level as defined by the Common European Framework of Reference for Languages. The study was carried out among university students majoring in Italian Language and Literature at the School of Philosophy, Letters and Humanities of the University of São Paulo, Brazil

The Serra de Tramuntana World Heritage Site (Mallorca, Spain). Landslide activity valuation by means of Persistent Scatterers Interferometry

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Mateos, Rosa Maria; Bianchini, Silvia; Herrera, Gerardo; Garcia, Inmaculada; Sanabria, Margarita

2016-04-01

planning activities in cultural heritage sites. References: Bianchini S, Herrera G, Mateos RM, Notti D, García-Moreno I, Mora O, Moretti S (2013). Landslide Activity Maps Generation by means of Persistent Scattered Interferometry. Remote Sensing 5:6198-6222. Mateos R.M., García-Moreno I., Herrera G., Mulas J (2013) a. Damage caused by recent mass-movements in Majorca (Spain), a region with a high risk due to tourism. Landslide Science and Practice. Claudio Margottini, Paolo Canuti and Kyoji Sassa (Editors). Volume 7: Social and Economic Impact and Policies. 105-113. Mateos RM, Rodríguez-Peces M, Azañón JM, Rodríguez-Fernández FJ, Roldán FJ, García-Moreno I, Gelabert B, García-Mayordomo J (2013)b. El deslizamiento de Bàlitx (Mallorca) y su posible origen sísmico. Procesos activos desde el Pleistoceno superior. Boletín Geológico y Minero, 124 (1): 41-61

PREFACE: International Conference on Computing in High Energy and Nuclear Physics (CHEP'09)

Science.gov (United States)

Gruntorad, Jan; Lokajicek, Milos

2010-11-01

Physics Milos Lokajicek (co-chair), Institute of Physics AS CR, v.v.i., Prague Vojtech Petracek, Czech Technical University in Prague, Faculty of Nuclear Sciences and Physical Engineering and especially the Programme Committee for their careful choice of conference contributions and their enormous work with organization of 340 post conference proceedings paper review Ludek Matyska (chair), CESNET Online Computing Volker Gülzow, DESY Jiri Masik, University of Manchester/on leave from Institute of Physics AS CR, Prague Event Processing Elizabeth Sexton-Kennedy, FNAL Tomas Davidek, Charles University, Prague Software Components, Tools and Databases Paolo Calafiura, LBNL Julius Hrivnac, LAL Track 4 Hardware and Computing Fabrics Takashi Sasaki, KEK Jiri Chudoba, Institute of Physics AS CR, Prague Grid Middleware and Networking Technologies Francesco Giacomini, CERN Ales Krenek, Masaryk University, Brno/CESNET Distributed Processing and Analysis Latchezar Betev, CERN Simon Lin, ASGC, Taipei Dagmar Adamova, Nuclear Physics Institute AS CR, Prague Collaborative Tools Eva Hladka, Masaryk University, Brno/CESNET Thank you to all who made CHEP'09 a success. Jan Gruntorad and Milos Lokajicek CHEP'09 Conference Chairs Prague, March 2010 The PDF and HTML files contain a list of all CHEP'09 contributions.

Comparative analysis of molecular signatures suggests the use of gabapentin for the management of endometriosis-associated pain

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Bellessort B

2018-04-01

Full Text Available Brice Bellessort,1 Anne Bachelot,1,2 Virginie Grouthier,2 Camille De Lombares,1 Nicolas Narboux-Neme,1 Paolo Garagnani,3,4 Chiara Pirazzini,3,4 Simonetta Astigiano,5 Luca Mastracci,6,7 Anastasia Fontaine,1 Gladys Alfama,1 Evelyne Duvernois-Berthet,1 Giovanni Levi1 1Evolution of Endocrine Regulations, Department AVIV, National Museum of Natural History, Paris, France; 2AP-HP, Department of Endocrinology and Reproductive Medicine, Reference Center for Rare Endocrine Diseases, Pitié-Salpêtrière Hospital, UPMC, Paris, France; 3Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy; 4Interdepartmental Center “L. Galvani”, University of Bologna, Bologna, Italy; 5Department of Integrated Oncological Therapies, San Martino Hospital, Genova, Italy; 6Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genoa, Genova, Italy; 7Division of Anatomic Pathology, Department of Surgical Science and Integrated Diagnostics, University of Genoa, Genova, Italy Background: It has been repetitively shown that the transcription factors DLX5 and DLX6 are drastically downregulated in endometriotic lesions when compared with eutopic endometrium. These findings suggest that regulatory cascades involving DLX5/6 might be at the origin of endometriosis symptoms such as chronic pelvic pain (CPP. We have shown that inactivation of Dlx5 and Dlx5/6 in the mouse uterus results in an endometrial phenotype reminiscent of endometriosis. Methods: We focused on genes that present a similar deregulation in endometriosis and in Dlx5/6-null mice in search of new endometriosis targets. Results: We confirmed a strong reduction of DLX5 expression in endometriosis implants. We identified a signature of 30 genes similarly deregulated in human endometriosis implants and in Dlx5/6-null mouse uteri, reinforcing the notion that the downregulation of Dlx5/6 is an early event in

Effect of 2,4-dichlorophenoxyacetic acid on rat maternal behavior

International Nuclear Information System (INIS)

Stuertz, Nelson; Deis, Ricardo P.; Jahn, Graciela A.; Duffard, Ricardo; Evangelista de Duffard, Ana Maria.

2008-01-01

Exposure to 2,4-dichlorophenoxyacetic acid (2,4-D) has several deleterious effects on the nervous system such as alterations in the concentrations of neurotransmitters in the brain and/or behavioral changes, myelination rate, ganglioside pattern [Bortolozzi, A., Duffard, R., Antonelli, M., Evangelista de Duffard, A.M., 2002. Increased sensitivity in dopamine D(2)-like brain receptors from 2,4-dichlorophenoxyacetic acid (2,4-D)-exposed and amphetamine-challenged rats. Ann. N.Y. Acad. Sci. 965, 314-323; Duffard, R., Garcia, G., Rosso, S., Bortolozzi, A., Madariaga, M., DiPaolo, O., Evangelista de Duffard, A.M., 1996. Central nervous system myelin deficit in rats exposed to 2,4-dichlorophenoxyacetic acid throughout lactation. Neurotoxicol. Teratol. 18, 691-696; Evangelista de Duffard, A.M., Orta, C., Duffard, R., 1990. Behavioral changes in rats fed a diet containing 2,4-dichlorophenoxyacetic butyl ester. Neurotoxicology 11, 563-572; Evangelista de Duffard, A.M., Bortolozzi, A., Duffard, R.O., 1995. Altered behavioral responses in 2,4-dichlorophenoxyacetic acid treated and amphetamine challenged rats. Neurotoxicology 16, 479-488; Munro, I.C., Carlo, G.L., Orr, J.C., Sund, K., Wilson, R.M. Kennepohl, E. Lynch, B., Jablinske, M., Lee, N., 1992. A comprehensive, integrated review and evaluation of the scientific evidence relating to the safety of the herbicide 2,4-D. J. Am. Coll. Toxicol. 11, 559-664; Rosso et al., 2000], and its administration to pregnant and lactating rats adversely affects litter growth and milk quality. Since normal growth of the offspring depends on adequate maternal nursing and care, we evaluated the effect of 2,4-D on rat maternal behavior as well as the dam's monoamine levels in arcuate nucleus (AcN) and serum prolactin (PRL) levels. Wistar dams were exposed to the herbicide through the food from post partum day (PPD) 1 to PPD 7. Dams were fed either with a 2,4-D treated diet (15, 25 or 50 mg 2,4-D/kg/day bw) or with a control diet. We observed

An innovative intervention for the treatment of cognitive impairment–Emisymmetric bilateral stimulation improves cognitive functions in Alzheimer’s disease and mild cognitive impairment: an open-label study

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Guerriero F

2015-09-01

Full Text Available Fabio Guerriero,1–3 Emanuele Botarelli,3 Gianni Mele,3 Lorenzo Polo,3 Daniele Zoncu,3 Paolo Renati,3,4 Carmelo Sgarlata,1 Marco Rollone,2 Giovanni Ricevuti,1,2 Niccolo Maurizi,1 Matthew Francis,1 Mariangela Rondanelli,5 Simone Perna,5 Davide Guido,2,6 Piero Mannu3 1Department of Internal Medicine and Medical Therapy, Section of Geriatrics, University of Pavia, Pavia, Italy; 2Agency for Elderly People Services, Santa Margherita Hospital, Pavia, Italy; 3Ambra Elektron, Italian Association of Biophysics for the Study of Electromagnetic Fields in Medicine, 4Alberto Sorti Research Institute, Medicine and Metamolecular Biology, Turin, Italy; 5Department of Public Health, Experimental and Forensic Medicine, Section of Human Nutrition, Endocrinology and Nutrition Unit, 6Department of Public Health, Experimental and Forensic Medicine, Biostatistics and Clinical Epidemiology Unit, University of Pavia, Pavia, Italy Background and aims: In the last decade, the development of different methods of brain stimulation by electromagnetic fields (EMF provides a promising therapeutic tool for subjects with impaired cognitive functions. Emisymmetric bilateral stimulation (EBS is a novel and innovative EMF brain stimulation, whose working principle is to introduce very weak noise-like stimuli through EMF to trigger self-arrangements in the cortex of treated subjects, thereby improving cognitive faculties. The aim of this pilot study was to investigate in patients with cognitive impairment the effectiveness of EBS treatment with respect to global cognitive function, episodic memory, and executive functions. Methods: Fourteen patients with cognitive decline (six with mild cognitive impairment and eight with Alzheimer’s disease underwent three EBS applications per week to both the cerebral cortex and auricular-specific sites for a total of 5 weeks. At baseline, after 2 weeks and 5 weeks, a neuropsychological assessment was performed through mini–mental state

Flood model for Brazil

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Palán, Ladislav; Punčochář, Petr

2017-04-01

Looking on the impact of flooding from the World-wide perspective, in last 50 years flooding has caused over 460,000 fatalities and caused serious material damage. Combining economic loss from ten costliest flood events (from the same period) returns a loss (in the present value) exceeding 300bn USD. Locally, in Brazil, flood is the most damaging natural peril with alarming increase of events frequencies as 5 out of the 10 biggest flood losses ever recorded have occurred after 2009. The amount of economic and insured losses particularly caused by various flood types was the key driver of the local probabilistic flood model development. Considering the area of Brazil (being 5th biggest country in the World) and the scattered distribution of insured exposure, a domain covered by the model was limited to the entire state of Sao Paolo and 53 additional regions. The model quantifies losses on approx. 90 % of exposure (for regular property lines) of key insurers. Based on detailed exposure analysis, Impact Forecasting has developed this tool using long term local hydrological data series (Agencia Nacional de Aguas) from riverine gauge stations and digital elevation model (Instituto Brasileiro de Geografia e Estatística). To provide most accurate representation of local hydrological behaviour needed for the nature of probabilistic simulation, a hydrological data processing focused on frequency analyses of seasonal peak flows - done by fitting appropriate extreme value statistical distribution and stochastic event set generation consisting of synthetically derived flood events respecting realistic spatial and frequency patterns visible in entire period of hydrological observation. Data were tested for homogeneity, consistency and for any significant breakpoint occurrence in time series so the entire observation or only its subparts were used for further analysis. The realistic spatial patterns of stochastic events are reproduced through the innovative use of d-vine copula

An eHealth Project on Invasive Pneumococcal Disease: Comprehensive Evaluation of a Promotional Campaign.

Science.gov (United States)

Panatto, Donatella; Domnich, Alexander; Gasparini, Roberto; Bonanni, Paolo; Icardi, Giancarlo; Amicizia, Daniela; Arata, Lucia; Carozzo, Stefano; Signori, Alessio; Bechini, Angela; Boccalini, Sara

2016-12-02

. Similarly, the postintervention daily trend in the number of users was positive, with a relative increase of 0.9% (95% CI 0.0%-1.8%) for the app and 1.4% (95% CI 0.7%-2.1%) for the website. Demographics differed between app and website users and Facebook fans. A total of 69.15% (10,793/15,608) of users could be defined as being at risk of IPD, while 4729 users expressed intentions to ask their doctor for further information on IPD. The mean app quality score assigned by end users was approximately 79.5% (397/500). Despite its specific topic, Pneumo Rischio was accessed by a considerable number of users, who ranked it as a high-quality project. In order to reach their target populations, however, such projects should be promoted. ©Donatella Panatto, Alexander Domnich, Roberto Gasparini, Paolo Bonanni, Giancarlo Icardi, Daniela Amicizia, Lucia Arata, Stefano Carozzo, Alessio Signori, Angela Bechini, Sara Boccalini. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 02.12.2016.

Protecting the Moon for research: ILEWG report

Science.gov (United States)

Foing, Bernard H.

. Cellino Editors), Ad-vances in Space Research, Volume 37, Issue 1, pp 1-192, 2006 -7th ILEWG Conference on Exploration and Utilisation of the Moon, Toronto Sept 2005, Programme and Proceedings on line at www.ilewg.org, R. Richards et al Editors -6th ILEWG Conference on Exploration and Utilisation of the Moon, Udaipur Nov. 2004, Proceedings ( N. Bhandari Editor), Journal Earth System Science, India, 114, No6, Dec 2005, pp. 573-841 -5th ILEWG Conference on Exploration and Utilisation of the Moon, Hawaii Nov 2003, Pro-ceedings ILC2005/ICEUM5 (S.M. Durst et al Editors), Vol 108, 1-576 pp, Science and Tech-nology Series, American Astronautical Society, 2004 -'The next steps in exploring deep space -A cosmic study by the IAA', W. Huntress, D. Stetson, R. Farquhar, J. Zimmerman, B. Clark, W. O'Neil, R. Bourke and B. Foing, Acta Astronautica, Vol 58, Issues 6-7, March-April 2006, p302-377 -IAA/ESA workshop on "Next Steps in Exploring Deep Space", ESTEC 22-23 sept. 2003 (B.H. Foing W. Huntress, conveners) Lunar Exploration, Planetary and Space Science, Vol 50, issue 14-15, Dec 2002 (B.H. Foing al) -ESLAB36 symposium on "Earth-like Planets and Moons", 2002, ESA-SP514, pp. 1-356, (B.H.Foing B. Battrick, editors) -'Lunar Exploration 2000', (B.H. Foing, D. Heather, Editors), Adv. Space Research Vol 30, Nr 8, 2002 -'Earth-Moon Relationships', Proceedings of the Conference held in Padova, Italy at the Ac-cademia Galileiana di Scienze Lettere ed Arti, Nov. 2000, (C. Barbieri and F. Rampazzi, Editors), in Earth, Moon , Planets Vol. 85-86, Nos 1-3, pp 1-575, 2001 -4th International Conference on Exploration and Utilisation of the Moon, ESTEC, 2000, ESA SP-462 (B.H. Foing M. Perry, editors) -Investing in Space: The Challenge for Europe. Long-Term Space Policy Committee, Second Report, May 1999. ESA-SP-2000 -2nd International Lunar Workshop, held at Kyoto in October 1996, Proceedings, H. Mizutani, editor, Japan Space Forum Publisher, 1997 International Lunar Workshop, 1994 May 31-June 3

Seasonal rockfall risk assessment along transportation network: a sample from Mallorca (Spain)

Science.gov (United States)

Mateos, Rosa Maria; Garcia, Inmaculada; Reichenbach, Paola; Herrera, Gerardo; Rius, Joan; Aguilo, Raul; Roldan, Francisco J.

2014-05-01

section of the road. For the risk analysis, four scenarios depending on the seasonal people exposition have been taken into account, considering the autumn as the season with the highest risk. This methodology can be applied to highly touristy areas such Mallorca, where the safety of the population and its visitors must be the priority of all concerned. References : Guzzetti, F., Crosta G., Detti, R. Agliardi, F., 2002: STONE: A computer program for the three-dimensional simulation of rock-falls. Computers Geosciences 28 (2002) 1079-1093. Mateos, R.M., García-Moreno, I., Azañón, J.M., 2012. Freeze-thaw cycles and rainfall as triggering factors of mass movements in a warm Mediterranean region: the case of the Tramuntana Range (Majorca, Spain). Landslides (2012), 9: 417-432. Mateos, R.M., García- Moreno, I., Herrera, G., Mulas, J., 2013b. Damage caused by recent mass-movements in Majorca (Spain), a region with a high risk due to tourism. Landslide Science and Practice. Claudio Margottini, Paolo Canuti and Kyoji Sassa (Editors). Volume 7: Social and Economic Impact and Policies. 105-113.

The Sun: the Earth light source

Science.gov (United States)

Berrilli, Francesco; Giovannelli, Luca; Del Moro, Dario; Piazzesi, Roberto; Catena, Liu` Maria; Amicucci, Giordano; Vittorio, Nicola

2015-04-01

Education and the National Program for the diffusion of Scientific Degrees (Progetto Lauree Scientifiche or PLS). In the last years has been mainly aimed to underline the connections between Astronomy, Astrophysics and the new materials involved in the astronomical techniques. The Sun has always been used in the course as a key element since the final product was the production of a self-constructed solar telescope able to be used to monitor the solar activity through Wolf's number estimation. In the third edition the project has been extended to other three Universities on the Italian territory: University of l'Aquila, University of Camerino and University of Calabria. Over the years more than 80 students and 50 teachers where directly involved and more than 50 different high schools on all the national territory, reaching thousands of their students in the final dissemination part of the program. 25 telescopes are currently in use in high school institutes all-over Italy. A book describing the project has been published by Springer in 2013 (STUDENTI-RICERCATORI per cinque giorni "Stage a Tor Vergata" Editors: Liù M. Catena, Francesco Berrilli, Ivan Davoli, Paolo Prosposito, ISBN: 978-88-470-5271-0 (Online) ), the link to the book describing the project and reporting student interviews is at: http://link.springer.com/book

Sr isotope characterization of atmospheric inputs to soils along a climate gradient of the Chilean Coastal Range

Science.gov (United States)

Oeser, Ralf; Schuessler, Jan A.; Floor, Geerke H.; von Blanckenburg, Friedhelm

2017-04-01

mobile soil layer to 0.70571 (n = 25). We find that atmospheric sources (87Sr/86Srseawater = 0.709234; [2]) contribute about 13 % of Sr to the soil and are a minor but not negligible fraction in comparison to weathering supply from saprolite. Furthermore, the 87Sr/86Sr ratios determined for saprolite samples are in good agreement with the values reported for the local Illapel Plutonic Complex [3]. Hence, the top-soil atmospheric inputs are potentially influencing the plant's strategies of nutrient uplift, ultimately controlled by the plants' nutrient demand as a function of climate. [1] Capo, R. C., Stewart, B. W., and Chadwick, O. A., 1998, Strontium isotopes as tracers of ecosystem processes: theory and methods: Geoderma, v. 82, no. 1-3, p. 197-225. [2] DePaolo, D. J., and Ingram, B. L., 1985, High-resolution stratigraphy with strontium isotopes: Science, v. 227, no. 4689, p. 938-941. [3] Parada, M. A., Nyström, J. O., and Levi, B., 1999, Multiple sources for the Coastal Batholith of central Chile (31-34˚ S): geochemical and Sr-Nd isotopic evidence and tectonic implications: Lithos, v. 46, no. 3, p. 505-521.

EDITORIAL: Focus on Dark Matter and Particle Physics

Science.gov (United States)

Aprile, Elena; Profumo, Stefano

2009-10-01

Doetinchem, H Gast, T Kirn and S Schael Axion searches with helioscopes and astrophysical signatures for axion(-like) particles K Zioutas, M Tsagri, Y Semertzidis, T Papaevangelou, T Dafni and V Anastassopoulos The indirect search for dark matter with IceCube Francis Halzen and Dan Hooper DIRECT DARK MATTER SEARCHES:EXPERIMENTS Gaseous dark matter detectors G Sciolla and C J Martoff Search for dark matter with CRESST Rafael F Lang and Wolfgang Seidel DIRECT AND INDIRECT PARTICLE DARK MATTER SEARCHES:THEORY Dark matter annihilation around intermediate mass black holes: an update Gianfranco Bertone, Mattia Fornasa, Marco Taoso and Andrew R Zentner Update on the direct detection of dark matter in MSSM models with non-universal Higgs masses John Ellis, Keith A Olive and Pearl Sandick Dark stars: a new study of the first stars in the Universe Katherine Freese, Peter Bodenheimer, Paolo Gondolo and Douglas Spolyar Determining the mass of dark matter particles with direct detection experiments Chung-Lin Shan The detection of subsolar mass dark matter halos Savvas M Koushiappas Neutrino coherent scattering rates at direct dark matter detectors Louis E Strigari Gamma rays from dark matter annihilation in the central region of the Galaxy Pasquale Dario Serpico and Dan Hooper DARK MATTER MODELS The dark matter interpretation of the 511 keV line Céline Boehm Axions as dark matter particles Leanne D Duffy and Karl van Bibber Sterile neutrinos Alexander Kusenko Dark matter candidates Lars Bergström Minimal dark matter: model and results Marco Cirelli and Alessandro Strumia Shedding light on the dark sector with direct WIMP production Partha Konar, Kyoungchul Kong, Konstantin T Matchev and Maxim Perelstein Axinos as dark matter particles Laura Covi and Jihn E Kim

1992 WAMET/EUROMET Joint Expedition to Search for Meteorites in the Nullarbor Region, Western Australia

Science.gov (United States)

Bevan, A.

1992-07-01

The Nullarbor Region is a limestone desert in the south of Australia. It forms part of the larger Eucla Basin, which straddles the border between South Australia and Western Australia. The portion of the Eucla Basin lying in Westem Australia covers an area of about 104,000 km^2 (Bevan and Binns, 1989) and meteorites have been recovered from this region since 1971, new material being deposited at the Western Australia Museum. Between 21/3/92 and 6/4/92 a joint expedition between the Western Australia Museum and EUROMET recovered approximately 440 specimens of meteorites (total mass 13206 g) and 297 tektites. The expedition, whose members were Claude Perron (Paris), Christian Koeberl (Vienna), Georg Delisle (BGR Hannover), Gian- Paolo Sighinolfi (Modena), and Andrew Morse (OU) for Euromet, together with Wayne Smith (Australian Army) and Tom Smith (Perth Astronomical Observatory), was led by Dr Alex Bevan of the Western Australia Museum. Searching was carried out on foot with the participants spread out in a line with a 10-m spacing, walking along a compass bearing for approximately 10 km and back each day. Eight collecting regions were used, with a stop of about 2 days at each camp. Half of the searching was done near known strewn fields in order that the team become practised. Thus the expedition collected material at the following known sites. Camel Donga, Eucrite: The initial recovery was made in 1984 (Cleverly et al., 1986). The strewn field is about 8 km by 2-3 km at coordinates 30 degrees 19'S, 126 degrees 37'E. This expedition recovered 65 stones weighing a total of 2456 g, plus one stone of 4.8 g that was clearly chondritic in hand specimen. Mulga (north), H6: The initial recovery was made in 1964 (McCall, 1968). The strewn field is 8 km by 2 km at coordinates 30 degrees 11'S, 126 degrees 22'E and on this expedition 5 stones were recovered with a weight of 548 g. Also 110 stones (total mass 1535 g) that are certainly not H6 were found within a 100-m radius of

Roadway management plan based on rockfall modelling calibration and validation. Application along the Ma-10 road in Mallorca (Spain)

Science.gov (United States)

Mateos, Rosa Maria; Garcia, Inmaculada; Reichenbach, Paola; Herrera, Gerardo; Sarro, Roberto; Rius, Joan; Aguilo, Raul

2016-04-01

taking into account, not only the success, but also the mistakes. We have further validated the calibrated parameters along the Ma-road using the 63 rockfall recorded during the past 18 years along the road. 81.5% of the rockfalls are well represented by STONE modelling. Results have been exploited by the Road Maintenance Service of Mallorca for the design of the following road management plan: (1) Phase 1. Short-term. Design a specific plan for the road- sections where rockfalls were registered and modelling results were obtained. A large investment will be expended for implementation of retention and protection measures. (2) Phase 2. Medium-term. Design a specific plan for the road- sections where rockfalls were registered but no modelling results were obtained. For these cases, new studies at local scale are necessary as well as the application of other modelling software which include higher resolution input data. (3) Phase 3. Long-term. Design a specific plan for the road- sections where no rockfalls were registered but modelling results were obtained. These are potential rockfall areas and local and specific ground studies are necessaries. References Mateos RM (2006) Los movimientos de ladera en la Serra de Tramuntana (Mallorca). Caracterización geomecánica y análisis de peligrosidad. PhD. Servicio de Publicaciones de la Universidad Complutense de Madrid. Madrid, 299 p. Mateos RM, García-Moreno I, Herrera G, Mulas J (2013) Damage caused by recent mass-movements in Majorca (Spain), a region with a high risk due to tourism.Landslide Science and Practice.Claudio Margottini, Paolo Canuti and KyojiSassa (Editors). Volume 7: Social and Economic Impact and Policies. 105-113. Guzzetti F, Crosta G, Detti R, Agliardi F (2002) STONE: A computer program for the three-dimensional simulation of rock-falls. Computers Geosciences. Vol. 28:1079-1093.

Original sounding and drifting balloon-borne measurements in the western Mediterranean with the aerosol counter/sizer LOAC during summer ChArMEx campaigns, with a focus on desert dust events

Science.gov (United States)

Renard, Jean-Baptiste; Dulac, François; Vignelles, Damien; Jeannot, Matthieu; Verdier, Nicolas; Chazette, Patrick; Crenn, Vincent; Sciare, Jean; Totems, Julien; Durand, Pierre; Barret, Brice; Jambert, Corinne; Mallet, Marc; Menut, Laurent; Mailler, Sylvain; Basart, Sara; Baldasano, José Maria

2015-04-01

LOAC (Light Optical Aerosol Counter) is a new small optical particle counter/sizer of ~250 grams designed to fly under all kinds of balloons. The measurements are conducted at two scattering angles (12° and 60°), allowing the determination of the aerosol particle concentrations in 19 size classes within a diameter range of ~0.2-100 µm and some identification of the nature of particles dominating different size classes. Following laboratory calibration, the sensor particularly discriminates wet or liquid particles, mineral dust, soot carbon particles and salts. Comparisons with other in situ sensors at the surface and with remote sensing measurements on the vertical were performed to give confidence in measurements. The instrument has been operated at the surface, under all kinds of balloons up to more than 35 km in altitude, including tethered, sounding, open stratospheric and new boundary-layer pressurized drifting balloons (BLPB) from CNES, and was tested on board a small UAV. Operations encompass a variety of environments including the Arctic (Reykjavik, Island, and Kiruna, Sweden), Brazil (Sao Paolo), the western Mediterranean Basin, southwestern France, peri-urban (Ile de France) and urban areas (Paris and Vienna). Presented results are focused on the LOAC balloon-borne measurements performed in the western Mediterranean basin during MISTRALS/ChArMEx campaigns (Mediterranean Integrated Studies aT Regional And Local Scales/the Chemistry-Aerosol Mediterranean Experiment; http://www.mistrals-hjome.org; http://charmex.lsce.ipsl.fr), with a focus on African dust events. Two test flights with a first version of LOAC under sounding balloons were first successfully performed in late June 2012 near Marseille during an intense dust event. In 2013, 19 LOAC flights have been performed under meteorological balloons and 12 under low altitude drifting balloons, most of them from Minorca Island (Spain) in June and early July and others from Levant Island (south of France

Detailed chronology of a giant Pleistocene rock-avalanche sequence in the hyperarid southern Peru revealed by jointly applied 10Be and 3He cosmic ray exposure dating : The Study case of the Cerro Caquilluco landslide complex.

Science.gov (United States)

Swann, Zerathe; Laurence, Audin; Carlos, Benavente; Régis, Braucher; Pierre-Henri, Blard; Didier, Bourlès; Julien, Carcaillet; Fabrizio, Delgado; Pascal, Lacroix; Valderrama Patricio, Murillo; Aster Team

2015-04-01

suggesting sequential failures, this object appeared as a good target to bring additional knowledge on the previously exposed issues. Our goal was to use TCN and to sample a maximum of individual lobes to be able to discuss: (i) the time of recurrence of successive extreme events, (ii) the respective roles of past climate variations versus earthquake forcing on the landslide trigger, and (iii) the impact of these mass remobilizations on local erosion rates compared to fluvial erosion rates and tectonic uplift rates (both known in this region). On average, three samples were extracted from individual meter-scale boulders sampled on seven different lobes of debris (~20 samples). Due to the lack of quartz in that volcanic lithology, 10Be was extracted from feldspaths for all samples. Half were additionally processed for 3He measurements on pyroxene, allowing to reduce the uncertainty on the derived exposure ages and to solve the production equation for both time and erosion variables. The obtained ages show a perfect consistency with the pattern of erosion, geomorphic surfaces and relative position of each lobes (i.e. younger from the toe to the top). These results highlight sequential failures staggered at the Pleistocene timescale, with some surprising time of recurrence ranging from 30 to 100 ka that may correspond to the main last climate variations in that region. Crosta, G.B., Hermanns, R.L., Frattini, P., Valbuzzi, E., Valagussa, A., 2014a. Large slope instabilities in Northern Chile: Inventory, Characterisation and Possible Triggers. In: Proceedings of the 3rd world landslide Forum, 2-6 June 2014, Bejing, p 6. DOI: 10.1007/978/-3-319-04996-0_28. Crosta, G.B., Paolo, F., Elena, V., Hermanns, R.L., 2014b. The Cerro Caquilluco-Cerrillos Negros Giant Rock Avalanches (Tacna, Peru). IAEG - Torino 2014, N°159. McPhillips, D., Bierman, P.R., Rood, D.H., 2014. Millennial-scale record of landslides in the Andes consistent with earthquake trigger. Nature Geoscience, DOI: 10

Book Reviews

Directory of Open Access Journals (Sweden)

Redactie KITLV

2004-07-01

Full Text Available -Bill Maurer, Mimi Sheller, Consuming the Caribbean: From Arawaks to Zombies. New York: Routledge, 2003. ix + 252 pp. -Norman E. Whitten, Jr., Richard Price ,The root of roots: Or, how Afro-American anthropology got its start. Chicago: Prickly Paradigm Press/University of Chicago Press, 2003. 91 pp., Sally Price (eds -Holly Snyder, Paolo Bernardini ,The Jews and the expansion of Europe to the West, 1450-1800. New York: Berghahn Books, 2001. xv + 567 pp., Norman Fiering (eds -Bridget Brereton, Seymour Drescher, The mighty experiment: Free labor versus slavery in British emancipation. New York: Oxford University Press, 2002. 307 pp. -Jean Besson, Kathleen E.A. Monteith ,Jamaica in slavery and freedom: History, heritage and culture. Kingston; University of the West Indies Press, 2002. xx + 391 pp., Glen Richards (eds -Michaeline A. Crichlow, Jean Besson, Martha Brae's two histories: European expansion and Caribbean culture-building in Jamaica. Chapel Hill: University of North Carolina Press, 2002. xxxi + 393 pp. -Christopher Schmidt-Nowara, Joseph C. Dorsey, Slave traffic in the age of abolition: Puerto Rico, West Africa, and the Non-Hispanic Caribbean, 1815-1859. Gainesville: University Press of Florida, 2003. xvii + 311 pp. -Arnold R. Highfield, Erik Gobel, A guide to sources for the history of the Danish West Indies (U.S. Virgin Islands, 1671-1917. Denmark: University Press of Southern Denmark, 2002. 350 pp. -Sue Peabody, David Patrick Geggus, Haitian revolutionary studies. Bloomington: Indiana University Press, 2002. xii + 334 pp. -Gerdès Fleurant, Elizabeth McAlister, Rara! Vodou, power, and performance in Haiti and its Diaspora. Berkeley: University of California Press, 2002. xviii + 259 pp. and CD demo. -Michiel Baud, Ernesto Sagás ,The Dominican people: A documentary history. Princeton NJ: Marcus Wiener, 2003. xiii + 278 pp., Orlando Inoa (eds -Samuel Martínez, Richard Lee Turits, Foundations of despotism: Peasants, the Trujillo regime

COASTALT Project's contribution to the development and dissemination of coastal altimetry

Science.gov (United States)

Cipollini, P.; Benveniste, J.

2012-04-01

, Machiel Bos, Valborg Byfield, Marco Caparrini, Peter Challenor, Paolo Cipollini, Henrique Coelho, Salvatore Dinardo, M. Joana Fernandes, Scott Gleason, Jesus Gómez-Enri, Christine Gommenginger, Clara Lázaro, Bruno M. Lucas, Cristina Martin-Puig, Laura Moreno, Alexandra Nunes, Nelson Pires, Graham Quartly, Andrea Scozzari, Helen Snaith, Mikis Tsimplis, Stefano Vignudelli, Luke J. West, Judith Wolf, Phil Woodworth

High Resolution HST Images of Pluto and Charon

Science.gov (United States)

1994-05-01

the physical properties of the two bodies, first of all their composition, surface structure and possible atmospheres. The analysis of data from a facility as complex as the Hubble Space Telescope is very demanding, and involves experts in many different fields: planetary astronomy, instrument technology, numerical image restoration, and spacecraft engineering. It is therefore not surprising that this investigation is expected to last a long time yet. However, while still in its preliminary stages, it already now appears to indicate the presence of areas of different reflectivity on the surface of Pluto. By a comparison of HST images obtained at two different wavelengths (i.e., in ultraviolet and visual light), the team members hope that it will become possible to construct rough maps of the planetary surface and perhaps also to answer the long-standing question of whether or not there is an atmosphere around Pluto. Notes: [1] This investigation is carried out at the Space Telescope European Coordinating Facility, which is located at the European Southern Observatory as part of a collaboration with the European Space Agency, and also involves other institutes in Europe and the U.S.A. The team of astronomers is headed by Rudolf Albrecht (ST-ECF), and includes Hans-Martin Adorf and Richard Hook (ST-ECF), Alessandra Gemmo and Olivier Hainaut (ESO), Cesare Barbieri and Gabriele Corrain (Osservatorio Astronomico di Padova, Italy), Chris Blades, Perry Greenfield and William Sparks (Space Telescope Science Institute, Baltimore, Maryland, U.S.A.) and David Tholen (Institute for Astronomy, University of Hawaii, U.S.A.). [2] The photo is available to the media from the ESO Information Service (address below) as ESO PR Photo 09/94-1 and from the Space Telescope Science Institute (Baltimore, USA) as STSci-PR94-17. Reproductions should be credited to NASA, ESA and ESO. Figure Caption Hubble Portrait of the "Double Planet" Pluto & Charon This is the clearest view yet of the distant

XXXI LIAC Meeting on Vascular Research - Proceedings

Directory of Open Access Journals (Sweden)

L. Monteiro Rodrigues et al.

2015-12-01

Speaker / Prelector Diogo Fonseca Panel Comunications | Comunicações em Posters Abstract List | Lista de Resumos Submetidos P.01 DENDRITIC CELLS TAKE PART TO EARLY AND LATE RESPONSE TO ISCHEMIC MYOCARDIAL INJURY. Paolo Romagnoli, Laura Pieri, Stefano Bacci, Beatrice Defraia, Gian Aristide Norelli, Aurelio Bonelli P.02 MICRORNA-CONTAINING MICROPARTICLES FROM VASCULAR SMOOTH MUSCLE CELLS ARE A POTENTIAL SOURCE OF BIOMARKERS. David de Gonzalo-Calvo, Ana Cenarro, Fernando Civeira F; Vicenta Llorente-Cortés. P.03 LASER DOPPLER FLOWMETRY (LDF AS AN ALTERNATIVE TECHNIQUE TO EVALUATE PERFUSION RECOVERY ON A MURINE MODEL OF HIND LIMB ISCHEMIA. Henrique Silva, Alain-Pierre Gadeau, Marie-Ange Renault, Hugo Ferreira, M Julia Bujan, L Monteiro Rodrigues. P.04 EXPLORING THE CUTANEOUS REACTIVITY TO LOCAL HEATING WITH THE WAVELET TRANSFORM – A PILOT STUDY. Henrique Silva, Hugo Ferreira, L Monteiro Rodrigues. P.05 CRYOPRESERVATION OF BIOENGINEERED, DECELLULARIZED AORTIC VALVES DOES NOT COMPROMISE THEIR PROPENSITY TO REPOPULATION BY HOST CELLS AND TISSUE REMODELLING. GOOD AND LESS GOOD OUTCOMES. Antonella Bonetti, Michele Gallo, Filippo Naso, Paolo Franci, Adolfo Paolin, Roberto Busetto, Michele Spina, Gino Gerosa, Fulvia Ortolani. P.06 PROMISING THERAPY TO TREAT CHRONIC ISCHEMIC SKIN DEFECTS USING A HYDROXYL-FARNASINE DERIVATIVE POLYPHENOL WITH A POTENT NADPH OXIDASE INHIBITION ACTIVITY. Pascual G., Mesa-Ciller C., Sotomayor S., Blanc-Guillemaud V., García-Honduvilla N., del Castillo E., Buján J. P.07 PLACENTAL STRUCTURAL ALTERATIONS IN PREGNANT WOMEN WITH VARICOSE VEIN PATHOLOGY. Mesa-Ciller, C.; Álvarez-Rocha, MJ.; Asúnsolo, A.; Payá, P.; Cifuentes, A.; García-Honduvilla, N.; Buján, J. P.08 EXPLORING THE EFFECT OF POSTURE ON THE PERIPHERAL CUTANEOUS MICROVASCULAR RESPONSE TO THE TOPICAL APPLICATION OF METHYL NICOTINATE. Henrique Silva, Catarina Rosado, Hugo Ferreira, Joana Antunes and L Monteiro Rodrigues. P.09 NAILFOLD CAPILLAROSCOPY CRITERIA FOR DISTINCTION OF PRIMARY AND

PREFACE: Semiconducting oxides Semiconducting oxides

Science.gov (United States)

Catlow, Richard; Walsh, Aron

2011-08-01

epitaxial In2O3 thin films grown on Y-stabilised ZrO2(111) K H L Zhang, V K Lazarov, T D Veal, F E Oropeza, C F McConville, R G Egdell and A Walsh Hydrogenated cation vacancies in semiconducting oxidesJ B Varley, H Peelaers, A Janotti and C G Van de Walle Reactive force field simulation of proton diffusion in BaZrO3 using an empirical valence bond approachPaolo Raiteri, Julian D Gale and Giovanni Bussi Conductivity in transparent oxide semiconductorsP D C King and T D Veal A theoretical study of a ZnO graphene analogue: adsorption on Ag(111) and hydrogen transportIlker Demiroglu, Daniele Stradi, Francesc Illas and Stefan T Bromley The interplay between dopants and oxygen vacancies in the magnetism of V-doped TiO2 Ricardo Grau-Crespo and Udo Schwingenschlögl Electron and hole stability in GaN and ZnOAron Walsh, C Richard A Catlow, Martina Miskufova and Alexey A Sokol Holes bound as small polarons to acceptor defects in oxide materials: why are their thermal ionization energies so high?O F Schirmer

LHC Nobel Symposium Proceedings

Science.gov (United States)

Ekelöf, Tord

2013-12-01

referees of these Proceedings and to the staff at Uppsala University, in particular my Administrative Assistant for the Symposium, Marja Fahlander, at the Royal Swedish Academy of Sciences, at the Nobel Foundation and at the Institute of Physics Publishing Company for Physica Scripta for realizing this enlightening Symposium at its proceedings. The Nobel Symposium was financed by the Nobel Foundation. Tord Ekelöf Chair of the LHC Nobel Symposium Local Organizing Committee and LHC Nobel Guest Editor for the Symposium Proceedings Members of the Local Organizing Committee of the LHC Nobel Symposium Tord Ekelöf (Uppsala University, Chair) Kerstin Jon-And (Stockholms University) Bengt Lund-Jensen (Royal Institute of Technology) Anders Oskarsson (Lunds University) Torsten Åkesson (Lund University) Barbro Åsman (Swedish Royal Academy of Sciences) Members of the International Advisory Committee of the LHC Nobel Symposium Pierluigi Campana (INFN Frascati) Fabiola Gianotti (CERN) Paolo Giubellino (INFN-Torino) Joe Incandela (UC Santa Barbara) Young-Kee Kim (FNAL) Michelangelo Mangano (CERN) Lisa Randall (Harvard University)

Something going on in Milan: a review of the 4th International PhD Student Cancer Conference.

Science.gov (United States)

Segré, C

2010-01-01

Maria Sarra Ferraris), due to the high scientific level of the abstracts submitted. In the end, 26 top students were chosen to give a 15-min oral presentation in one of eight sessions: Development & Differentiation, Cell Migration, Immunology & Cancer, Modelling & Large Scale approaches, Genome Instability, Signal Transduction, Cancer Genetics & Drug Resistance, Stem Cells in Biology and Cancer.The scientific programme was further enriched by two scientific special sessions, held by Professor Pier Paolo di Fiore and Dr Giuseppe Testa, Principal Investigators at the IFOM-IEO-Campus and by a bioethical round table on human embryonic stem cell research moderated by Silvia Camporesi, a senior PhD student in the SEMM PhD Programme 'Foundation of Life Science and their Bioethical Consequences'.ON TOP OF EVERYTHING, WE HAD THE PLEASURE OF INVITING, AS KEYNOTE SPEAKERS, TWO LEADING EUROPEAN SCIENTISTS IN THE FIELDS OF CANCER INVASION AND BIOLOGY OF STEM CELLS, RESPECTIVELY: Dr Peter Friedl from The Nijmegen Centre for Molecular Life (The Netherlands) and Professor Andreas Trumpp from The Heidelberg Institute for Stem Cell Technology and Experimental Medicine (Heidelberg).All the student talks have distinguished themselves for the impressive quality of the science; an encouraging evidence of the high profile level of research carried out in Europe. It would be beyond the purposes of this report to summarise all 26 talks, which touched many different and specific topics. For further information, the Conference Abstract book with all the scientific content is available on the conference Web site (http://www.semm.it/events_researchPast.php). In what follows, the special sessions and the keynote lectures will be discussed in detail.

First Temperate Exoplanet Sized Up

Science.gov (United States)

2010-03-01

(Hawaii), the Isaac Newton Telescope (Roque de los Muchachos Observatory), Wise Observatory (Israel), the Faulkes North Telescope of the Las Cumbres Observatory Global Telescope Network (Hawaii) and the ESO 3.6-metre telescope (Chile). More information This research was presented in a paper published this week in Nature ("A transiting giant planet with a temperature between 250 K and 430 K"), by H. J. Deeg et al. The team is composed of H.J. Deeg, B. Tingley, J.M. Almenara, and M. Rabus (Instituto de Astrofısica de Canarias, Tenerife, Spain), C. Moutou, P. Barge, A. S. Bonomo, M. Deleuil, J.-C. Gazzano, L. Jorda, and A. Llebaria (Laboratoire d'Astrophysique de Marseille, Université de Provence, CNRS, OAMP, France), A. Erikson, Sz. Csizmadia, J. Cabrera, P. Kabath, H. Rauer (Institute of Planetary Research, German Aerospace Center, Berlin, Germany), H. Bruntt, M. Auvergne, A. Baglin, D. Rouan, and J. Schneider (Observatoire de Paris-Meudon, France), S. Aigrain and F. Pont (University of Exeter, UK), R. Alonso, C. Lovis, M. Mayor, F. Pepe, D. Queloz, and S. Udry (Observatoire de l'Université de Genève, Switzerland), M. Barbieri (Università di Padova, Italia), W. Benz (Universität Bern, Switzerland), P. Bordé, A. Léger, M. Ollivier, and B. Samuel (Institut d'Astrophysique Spatiale, Université Paris XI, Orsay, France), F. Bouchy and G. Hébrard (IAP, Paris, France), L. Carone and M. Pätzold (Rheinisches Institut für Umweltforschung an der Universität zu Köln, Germany), S. Carpano, M. Fridlund, P. Gondoin, and R. den Hartog (ESTEC/ESA, Noordwijk, The Netherlands), D. Ciardi (NASA Exoplanet Science Institute/Caltech, USA), R. Dvorak (University of Vienna, Austria), S. Ferraz-Mello (Universidade de São Paulo, Brasil), D. Gandolfi, E. Guenther, A. Hatzes, G. Wuchterl, B. Stecklum (Thüringer Landessternwarte, Tautenburg, Germany), M. Gillon (University of Liège, Belgium), T. Guillot and M. Havel (Observatoire de la Côte d' Azur, Nice, France), M. Hidas, T. Lister

Libro de un Médico del Siglo XVI

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Fernando Serpa Florez

1986-12-01

orden del rey taciturno, aún no se sabe exactamente por qué causa, aunque don Gregario Marañón (2 presume, en su biografía de Antonio Pérez, valido de don Felipe, que fue debido a las intrigas palaciegas que llevaron al asesinato de Juan de Escobedo, Secretario en el gobierno de los Países Bajos de don Juan de Austria, el hermano bastardo del rey español, para acallar cualquier infidencia sobre las relaciones entre la princesa y Antonio Pérez. Para otros la amistad era con don Felipe, aunque la austeridad del monarca no da pie para pensar en ello.

En el vértice de tantas intrigas se halló nuestro galeno escritor y aún fue llamado, afirma él, a prestar sus servicios al infante don Carlos. De su prudencia y discreción nos habla el talento con que esquivó hacerse cargo del ilustre enfermo, en este paso operático (con tema de Schiller y música de Verdi, pues no debía ser un paciente fácil el degenerado príncipe cuya muerte se llegó a pensar fue ordenada por su regio padre para evitar a España un monarca indigno -otros dicen que debido a los celos por las relaciones de aquel con su madrastra, Isabel de Valois-. De todos modos el Infante don Carlos era un caso de difícil tratamiento. Esquizofrénico paranoide, es el diagnóstico histórico que de él hace Vallejo Nájera (3: retardado mental, de cabeza muy grande para su cuerpo. “No me gusta su aspecto, no sé lo que será de él” comentaba su abuelo el Gran Emperador. Y Paolo Tiépolo, embajador de Venecia, nos lo describe así: “Su estatura es más bien baja, su cara es fea y desagradable; su complexión melancólica, con desvarío en algunos casos, quebrantos (que como parece, ha heredado de su abuelo y de su bisabuela” (Juana la Loca. Otro de sus biógrafos (4 recuerda que “por el hecho más nimio monta en cólera y trata de asesinar a cualquiera, sin parar mientes en dignidades ni importancia. En uno de estos raptos trata de matar al Duque de Alba y a un cardenal”. Qué podr

PREFACE: IARD 2012: 8th Biennial Conference on Classical and Quantum Relativistic Dynamics of Particles and Fields

Science.gov (United States)

Horwitz, L. P.; Land, Martin C.; Gill, Tepper; Lusanna, Luca; Salucci, Paolo

2013-04-01

) Luca Lusanna (National Institute for Nuclear Physics, INFN) Benoit Famaey (Observatoire Astronomique de Strasbourg, CNRS) The organizers express their gratitude to the Galileo Galilei Institute for Theoretical Physics for its support and the use of its excellent facilities, and to INFN for its generous support. Finally, we thank the participants who contributed through their lectures, personal discussions, and these papers, to the advancement of the subject and our understanding. For the Editors and Organizing Committee, L P Horwitz (Tel-Aviv University, Bar Ilan University), Editor-in-Chief Luca Lusanna (INFN), Chairman of the Local Organizing committee Tepper Gill (Howard University), IARD Treasurer Martin Land (Hadassah College), IARD President Paolo Salucci (SISSA)

Exploring the learning context in shifts between online and offline learning

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Karen Borgnakke

2015-11-01

Together: Designing Participatory Research in Online Ethnography Paolo Landri, Andrea Maccarini, Rosanna De Rosa (EdsCNR-IRPPS e-publishing http://www.irpps.cnr.it/e-pub/ojs/index.php/mono/article/view/978-88-98822-02-7.Copenhagen 2014:Rethinking Educational Ethnography: Researching on-line communities and interactionshttp://pur.mef.ku.dk/itaka/konferencer/ree/Karen Borgnakke professor, Department of Media, Cognition and Communication, karenb@hum.ku.dkFaculty of HumanitiesUniversity of CopenhagenKaren Blixens Vej 4DK-2300 København S

6th International Symposium on Molecular Allergology (ISMA

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Christiane Hilger

2016-10-01

-patient quantification of allergen-specific IgE Petra Zavadakova, Aurélie Buchwalder, Fabien Rebeaud, Iwan Märki Symposium 4: Relevance of molecular diagnostics for intervention and treatment O7 Longitudinal analysis of Bet v 1-specific epitope repertoires during birch pollen immunotherapy Barbara Gepp, Nina Lengger, Christian Möbs, Wolfgang Pfützner, Christian Radauer, Barbara Bohle O8 A natural CCD-free tool: is polistes sp. venom suitable for polybia paulista diagnosis and therapy? Karine Marafigo De Amicis, Alexandra Sayuri Watanabe, Clovis Eduardo Galvao, Daniele Danella Figo, Jose Roberto Aparecido Santos-Pinto, Mario Sergio Palma, Fabio Fernandes Morato Castro, Jorge Kalil, Fatima Ferreira, Gabriele Gadermaier, Keity Souza Santos Symposium 5: The advent of molecular allergology in epidemiology O9 Peanut oleosins: from identification to diagnostic testing Christian Schwager, Skadi Kull, Frauke Schocker, Jochen Behrends, Wolf-Meinhard Becker, Uta Jappe O10 Endotypes of oral allergy syndrome in childhood: a molecular diagnostic approach Carla Mastrorilli, Salvatore Tripodi, Carlo Caffarelli, Riccardo Asero, Arianna Dondi, Giampaolo Ricci, Carlotta Povesi Dascola, Elisabetta Calamelli, Andrea Di Rienzo Businco, Annamaria Bianchi, Tullio Frediani, Carmen Verga, Iride Dello Iacono, Diego Peroni, Giuseppe Pingitore, Roberto Bernardini, Paolo Maria Matricardi Symposium 6: Molecular AIT: which approaches will make it to market? O11 Mbc4: an innovative molecule to tackle birch pollen and concomitant food allergies Heidi Hofer, Claudia Asam, Michael Hauser, Peter Briza, Martin Himly, Christof Ebner, Fatima Ferreira O12 Challenges and solutions associated with the production of recombinant Bet v 1 allergen as a therapeutic protein Emmanuel Nony, Maxime Le Mignon, Pierrick Lemoine, Karine Jain, Kathy Abiteboul, Monica Arvidsson, Sabina Rak, Philippe Moingeon Clinical Cases: Breakthroughs and headaches from CRD: interactive session CC1 Anaphylaxis caused by lipid transfer proteins: a

PREFACE: Rutherford Centennial Conference on Nuclear Physics

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Freeman, Sean

2012-09-01

Dobacewski (Warsaw, Poland) G Dracoulis (ANU, Australia) S J Freedman (LBL, USA) M Hass (Weizmann Institute, Israel) M Huyse (Leuven, Belgium) P Jones (Birmingham, UK) D Khao (Hanoi, Vietnam) R Krücken (Munich, Germany) K Langanke (Darmstadt, Germany) C Lister (Argonne, USA) G A Miller (University of Washington, USA) D Morrissey (MSU, USA) T Motobayashi (RIKEN, Japan) S Nagamiya (J-PARC, Japan) W Nazarewicz (ORNL, USA) S Mullins (iThemba, South Africa) T Nakamura (Tokyo, Japan) P Roussel Chomaz (GANIL, France) R Ribas (Sao Paolo, Brazil) M Vanderhaeghen (Mainz, Germany) U Wiedner (Uppsala, Sweden) F Xu (Peking University, China) Q Zhao (IHEP, Bejing) W Zajc (Columbia, USA)

EDITORIAL: Focus on Mechanical Systems at the Quantum Limit FOCUS ON MECHANICAL SYSTEMS AT THE QUANTUM LIMIT

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Aspelmeyer, Markus; Schwab, Keith

2008-09-01

Mechanical feedback in the high-frequency limit R El Boubsi, O Usmani and Ya M Blanter Back-action evasion and squeezing of a mechanical resonator using a cavity detector A A Clerk, F Marquardt and K Jacobs Simultaneous cooling and entanglement of mechanical modes of a micromirror in an optical cavity Claudiu Genes, David Vitali and Paolo Tombesi Dispersive optomechanics: a membrane inside a cavity A M Jayich, J C Sankey, B M Zwickl, C Yang, J D Thompson, S M Girvin, A A Clerk, F Marquardt and J G E Harris Cavity-assisted backaction cooling of mechanical resonators I Wilson-Rae, N Nooshi, J Dobrindt, T J Kippenberg and W Zwerger Cavity cooling of a nanomechanical resonator by light scattering I Favero and K Karrai Probing the quantum coherence of a nanomechanical resonator using a superconducting qubit: II. Implementation M P Blencowe and A D Armour Probing the quantum coherence of a nanomechanical resonator using a superconducting qubit: I. Echo scheme A D Armour and M P Blencowe Nanoelectromechanics of suspended carbon nanotubes A K Hüttel, M Poot, B Witkamp and H S J van der Zant Prospects for cooling nanomechanical motion by coupling to a superconducting microwave resonator J D Teufel, C A Regal and K W Lehnert

PREFACE: First Mediterranean Conference on Classical and Quantum Gravity (MCCQG 2009)

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Basilakos, Spyros; Cadoni, Mariano; Cavaglia, Marco; Christodoulakis, Theodosios; Vagenas, Elias C.

2010-04-01

, India) Liberati, Stefano (SISSA, Trieste, Italy) Lopez-Villarejo, Juan Jose (Dep. de Física Teorica, Univ. Autonoma de Madrid, Spain) Louko, Jorma (University of Nottingham, UK) Lusanna, Luca (Sezione INFN di Firenze, Italy) Majumdar, Archan S (S N Bose National Centre for Basic Sciences, India) Melis, Maurizio (Università di Cagliari and INFN, Italy) Menotti, Pietro (Department of Physics, University of Pisa, Italy) Mignemi, Salvatore (Università di Cagliari, Italy) Monni, Cristina (Università di Cagliari and INFN, Italy) Pani, Paolo (Università di Cagliari and INFN, Italy) Papazoglou, Antonios (ICG, University of Portsmouth, UK) Páramos, Jorge (Instituto de Plasmas e Fusāo Nuclear, IST, Portugal) Pavsic, Matej (Jozef Stefan Institute, Slovenia) Perivolaropoulos, Leandros (University of Ioannina, Greece) Plionis, Manolis (Institute of Astronomy & Astrophysics, National Observatory of Athens, Greece) Pons, Josep (Universitat de Barcelona, Spain) Pouri, Athina (University of Athens, Greece) Radicella, Ninfa (Polytechnic of Turin, Italy) Rocha, Jorge (IST, Portugal) Russo, Jorge (ICREA, Universitat de Barcelona, Spain) Sakai, Norisuke (Department of Mathematics, Tokyo Woman's Christian University, Japan) Sakellariadou, Mairi (Department of Physics, King's College University of London, UK) Salisbury, Donald (Austin College, USA and MPI for the History of Science, Germany) Shnir, Yakov (National University of Ireland, Maynooth and DIAS, Ireland) Skenderis, Kostas (Institute for Theoretical Physics, University of Amsterdam, Netherlands) Sotiriou, Thomas (DAMTP, Cambridge, UK) Sundermeyer, Kurt (Free University Berlin Institute for Theoretical Physics, Germany) Tartaglia, Angelo (DIFIS, Politecnico and INFN, Torino, Italy) Vagenas, Elias (RCAAM, Academy of Athens, Greece) Wallden, Petros (Raman Research Institute, India) Wang, Bin (Fudan University, China) Weinfurtner, Silke (University of British Columbia, Canada) Zampeli, Mando (National Technical University of

First Solid Evidence for a Rocky Exoplanet - Mass and density of smallest exoplanet finally measured

Science.gov (United States)

2009-09-01

, making its real mass unknown. In the case of CoRoT-7b, as the planet is transiting, the geometry is well defined, allowing the astronomers to measure the mass of the planet precisely. More information This research was presented in a paper to appear in a special issue of the Astronomy and Astrophysics journal on CoRoT, volume 506-1, 22 October 2009: "The CoRoT-7 planetary system: two orbiting Super-Earths", by D. Queloz et al. The team is composed of D. Queloz, R. Alonso, C. Lovis, M. Mayor, F. Pepe, D. Segransan, and S. Udry (Observatoire de Genève, Switzerland), F. Bouchy, F. and G. Hébrard, G. (IAP, Paris, France), C. Moutou, M. Barbieri, P. Barge, M. Deleuil, L. Jorda, and A. Llebaria (Laboratoire d'Astrophysique de Marseille, France), A. Hatzes, D. Gandolfi, E. Guenther, M. Hartmann, and G. Wuchterl (Thüringer Landessternwarte Tautenburg, Germany), M. Auvergne, A. Baglin, D. Rouan, and J. Schneider (LESIA, CNRS, Observatoire de Paris, France), W. Benz (University of Bern, Switzerland), P. Bordé, A. Léger, and M. Ollivier (IAS, UMR 8617 CNRS, Université Paris-Sud, France), H. Deeg (Instituto de Astrofísica de Canarias, Spain), R. Dvorak (University of Vienna, Austria), A. Erikson and H. Rauer (DLR, Berlin, Germany), S. Ferraz Mello (IAG-Universidade de Sao Paulo, Brazil), M. Fridlund (European Space Agency, ESTEC, The Netherlands), M. Gillon and P. Magain (Université de Liège, Belgium), T. Guillot (Observatoire de la Côte d'Azur, CNRS UMR 6202, Nice France), H. Lammer (Austrian Academy of Sciences), T. Mazeh (Tel Aviv University, Israel), and M. Pätzold (Köln University, Germany). ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 14 countries: Austria, Belgium, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an

Enhanced recovery after surgery and video-assisted thoracic surgery lobectomy: the Italian VATS Group**List of collaborators of the Italian ERAS Group: Jacopo Vannucci, MD (University of Perugia); Antonio D’Andrilli, MD (S. Andrea Hospital, Roma); Majed Refai, MD (Ospedali Riuniti, Ancona); Guendalina Graffigna, MD (Università Cattolica del Sacro Cuore, Milano); Stefano Lovadina, MD (Ospedali Riuniti, Trieste); Marzia Umari (Ospedali Riuniti, Trieste), Paolo Ferrari, MD (IRCCS ISMETT-UPMC, University of Pittsburgh, Palermo); Michele Zuliani, MD (Ospedali Riuniti, Trieste); Marco Taurchini, MD (Casa Sollievo della Sofferenza, San Giovanni Rotondo); Carlo Del Naja, MD (Casa Sollievo della Sofferenza, San Giovanni Rotondo); Domenico Massullo, MD (S. Andrea Hospital, Roma), Olha Putina, MD (ASST Mantova), Nicoletta Pia Ardò (University of Foggia). surgical protocol

Science.gov (United States)

Viggiano, Domenico; Voltolini, Luca; Bertani, Alessandro; Bertolaccini, Luca; Crisci, Roberto; Droghetti, Andrea

2018-01-01

Enhanced recovery after surgery (ERAS®) is a strategy that seeks to reduce patients’ perioperative stress response, thereby reducing potential complications, decreasing hospital length of stay and enabling patients to return more quickly to their baseline functional status. The concept was introduced in the late 1990s and was first adopted in patients undergoing open colorectal surgery. Since then, the concept of ERAS has been adopted by multiple surgical specialties. The diffusion of video-assisted thoracic surgery lobectomy (VATS-L) sets also the surgical treatment of lung cancer as a new area for ERAS development. In this paper, we present the Italian VATS Group (www.vatsgroup.org) surgical protocol as part of the ERAS clinical pathway belonging to the VATS-L national database. PMID:29629203

Corneal surface reconstruction - a short review

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Madhavan H N

2009-01-01

Full Text Available Cornea is the clear, dome-shaped surface that covers the front of the eye and when damage due to burns or injury and several other diseases, stem cells residing in its rim called "limbus" are stimulated to multiply to support growth of new epithelial cells over its surface. If this ready source of stem cells is damaged or destroyed the natural repair is not possible and such a condition is known as corneal limbal stem cell deficiency (CLSCD disease. Stem cell transplant helps such persons to regenerate the corneal surface. Human corneal limbal stem cell transplantation is at present an established procedure with reasonable good clinical outcome particularly when autologous limbal epithelial tissue from a fellow unaffected eye is used. 1, 2 A major concern related to the autograft is the possibility of CLSCD at the donor site, 3 techniques that allowed the expansion of a small limbal biopsy in the laboratory using cell cultures that could be then transplanted to the affected eye have been developed ,4, 5 Human amniotic membrane (HAM is used as a scaffold for both culturing the human limbal epithelial cells and for ocular surface reconstruction with the cultured limbal epithelial cells. 4-7 However, researchers have used alternative scaffolds like collagen 8, fibrin gel 9 and cross-linked gel of fibronectin and fibrin. 10 All these are biological materials and also need for animal 3T3 feeder layer for stem cell cultures. The properties of HAM are unique including antiadhesive effects, bacteriostatic effects, wound protection, pain reduction, and improvement of epithelialization and characteristically lacking imunogenicity. The use of amniotic membrane transplantation (AMT to treat ocular surface abnormalities was first reported by Graziella Pellegrini, chief of stem cell laboratory at Giovanni Paolo Hospital in Venice, Italy, who was the first to demonstrate the limbal stem cell transplant in 1997. Amniotic membrane has been successfully used in

PREFACE: Dynamics of low-dimensional systems Dynamics of low-dimensional systems

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Bernasconi, M.; Miret-Artés, S.; Toennies, J. P.

2012-03-01

Chulkov Surface phonons on Pb(111) I Yu Sklyadneva, R Heid, K-P Bohnen, P M Echenique and E V Chulkov Using evidence from nanocavities to assess the vibrational properties of external surfaces G F Cerofolini, F Corni, S Frabboni, G Ottaviani, E Romano, R Tonini and D Narducci Magnetic properties and relaxation dynamics of a frustrated Ni7 molecular nanomagnet E Garlatti, S Carretta, M Affronte, E C Sañudo, G Amoretti and P Santini A theoretical study of rotational and translational diffusion dynamics of molecules with a six-fold point symmetry adsorbed on a hexagonal lattice by neutron scattering I Calvo-Almazán, S Miret-Artés and P Fouquet Vibrational dynamics and surface structure of Bi(111) from helium atom scattering measurements M Mayrhofer-Reinhartshuber, A Tamtögl, P Kraus, K H Rieder and W E Ernst Double and triple ionization of silver clusters by electron impactAvik Halder, Anthony Liang, Chunrong Yin and Vitaly V Kresin Scattering of O2 from a graphite surface W W Hayes, Junepyo Oh, Takahiro Kondo, Keitaro Arakawa, Yoshihiko Saito, Junji Nakamura and J R Manson Zero-phonon lines of systems with different dimensions and unconventional vibronic interactions V Hizhnyakov A kinetic Monte Carlo approach to investigate antibiotic translocation through bacterial porins Matteo Ceccarelli, Attilio V Vargiu and Paolo Ruggerone Quantum Zeno and anti-Zeno effects in surface diffusion of interacting adsorbates H C Peñate-Rodrìguez, R Martìnez-Casado, G Rojas-Lorenzo, A S Sanz and S Miret-Artés Weakly bound finite systems: (4He)N-Rb2(3Σu), clustering structures from a quantum Monte Carlo approach D López-Durán, R Rodrìguez-Cantano, T González-Lezana, G Delgado-Barrio, P Villarreal, E Yurtsever and F A Gianturco Multiphonon atom-surface scattering from corrugated surfaces: derivation of the inelastic scattering spectrum for diffraction statesBranko Gumhalter Probing the non-pairwise interactions between CO molecules moving on a Cu(111) surfacePepijn R Kole, Holly

Preface: Introductory Remarks: Linear Scaling Methods

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Bowler, D. R.; Fattebert, J.-L.; Gillan, M. J.; Haynes, P. D.; Skylaris, C.-K.

2008-07-01

Haynes, Chris-Kriton Skylaris, Arash Mostofi and Mike Payne A miscellaneous overview of SIESTA algorithms Jose M Soler Wavelets as a basis set for electronic structure calculations and electrostatic problems Stefan Goedecker Wavelets as a basis set for linear scaling electronic structure calculationsMark Rayson O(N) Krylov subspace method for large-scale ab initio electronic structure calculations Taisuke Ozaki Linear scaling calculations with the divide-and-conquer approach and with non-orthogonal localized orbitals Weitao Yang Toward efficient wavefunction based linear scaling energy minimization Valery Weber Accurate O(N) first-principles DFT calculations using finite differences and confined orbitals Jean-Luc Fattebert Linear-scaling methods in dynamics simulations or beyond DFT and ground state properties An O(N) time-domain algorithm for TDDFT Guan Hua Chen Local correlation theory and electronic delocalization Joseph Subotnik Ab initio molecular dynamics with linear scaling: foundations and applications Eiji Tsuchida Towards a linear scaling Car-Parrinello-like approach to Born-Oppenheimer molecular dynamics Thomas Kühne, Michele Ceriotti, Matthias Krack and Michele Parrinello Partial linear scaling for quantum Monte Carlo calculations on condensed matter Mike Gillan Exact embedding of local defects in crystals using maximally localized Wannier functions Eric Cancès Faster GW calculations in larger model structures using ultralocalized nonorthogonal Wannier functions Paolo Umari Other approaches for linear-scaling, including methods formetals Partition-of-unity finite element method for large, accurate electronic-structure calculations of metals John E Pask and Natarajan Sukumar Semiclassical approach to density functional theory Kieron Burke Ab initio transport calculations in defected carbon nanotubes using O(N) techniques Blanca Biel, F J Garcia-Vidal, A Rubio and F Flores Large-scale calculations with the tight-binding (screened) KKR method Rudolf Zeller

UVES Investigates the Environment of a Very Remote Galaxy

Science.gov (United States)

2002-03-01

present time. More information The results described in this Press Release are presented in a research paper "The Lyman-alpha forest of a Lyman-Break Galaxy: VLT Spectra of MS 1512-cB58 at z = 2.724" by Sandra Savaglio, Nino Panagia and Paolo Padovani, appearing in the research journal "Astrophysical Journal" this month. Notes [1]: The team consists of Sandra Savaglio (Johns Hopkins University, Baltimore, MD, USA, and Rome Observatory, Italy), Nino Panagia and Paolo Padovani (both European Space Agency and Space Telescope Science Institute, Baltimore) [2]: The measured redshift of MS 1512-cB58 is z = 2.724. In astronomy, the redshift denotes the fraction by which the lines in the spectrum of an object are shifted towards longer wavelengths. The observed redshift of a distant cloud or galaxy gives a direct estimate of the apparent recession velocity as caused by the universal expansion. Since the expansion rate increases with distance, the velocity is itself a function (the Hubble relation) of the distance to the object. The distances indicated in the text are based on an age of the Universe of 15 billion years. At the indicated redshift, the Lyman-alpha line of atomic hydrogen (rest wavelength 121.6 nm) is observed at 452.8 nm, i.e. in the blue spectral region. The Lyman-alpha absorption lines from intergalactic clouds along the line-of-sight (and at lower redshifts) are observed at shorter wavelengths. The lower limit of the UVES spectrum of MS 1512-cB58 (415 nm) corresponds to a Lyman-alpha redshift of 2.41, i.e. a distance of about 7.5 billion light-years. [3]: The importance of the Lyman-alpha line in absorption is that it is exquisitely sensitive to the presence of neutral hydrogen which only constitutes a small fraction of the total amount of hydrogen in the intergalactic medium (about 1/10,000). Still, the observed Ly-alpha forest is extremely rich. What we see is most likely the "tip of the iceberg" only and hydrogen in the intergalactic medium at high redshift is

Adaptive Optics for Industry and Medicine

Science.gov (United States)

Dainty, Christopher

2008-01-01

. Improved beam quality of a high power Yb: YAG laser (oral paper) / Dennis G. Harris ... [et al.]. Intracavity adaptive optics optimization of an end-pumped Nd:YVO4 laser (oral paper) / Petra Welp, Ulrich Wittrock. New results in high power lasers beam correction (oral paper) / Alexis Kudryashov ... [et al.]. Adaptive optical systems for the Shenguang-III prototype facility (oral paper) / Zeping Yang ... [et al.]. Adaptive optics control of solid-state lasers (poster paper) / Walter Lubeigt ... [et al.]. Gerchberg-Saxton algorithm for multimode beam reshaping (poster paper) / Inna V. Ilyina, Tatyana Yu. Cherezova. New algorithm of combining for spatial coherent beams (poster paper) / Ruofu Yang ... [et al.]. Intracavity mode control of a solid-state laser using a 19-element deformable mirror (poster paper) / Ping Yang ... [et al.] -- pt. 6. Adaptive optics in communication and atmospheric compensation. Fourier image sharpness sensor for laser communications (oral paper) / Kristin N. Walker and Robert K. Tyson. Fast closed-loop adaptive optics system for imaging through strong turbulence layers (oral paper) / Ivo Buske and Wolfgang Riede. Correction of wavefront aberrations and optical communication using aperture synthesis (oral paper) / R. J. Eastwood ... [et al.]. Adaptive optics system for a small telescope (oral paper) / G. Vdovin, M. Loktev and O. Soloviev. Fast correction of atmospheric turbulence using a membrane deformable mirror (poster paper) / Ivan Capraro, Stefano Bonora, Paolo Villoresi. Atmospheric turbulence measurements over a 3km horizontal path with a Shack-Hartmann wavefront sensor (poster paper) / Ruth Mackey, K. Murphy and Chris Dainty. Field-oriented wavefront sensor for laser guide stars (poster paper) / Lidija Bolbasova, Alexander Goncharov and Vladimir Lukin.

Maestro di Pico i iluminacije u inkunabuli De Civitate Dei (Nicolas Jenson, Venecija, 1475. u samostanu Sv. Duje u Kraju na Pašmanu

Directory of Open Access Journals (Sweden)

Bojan Goja

2014-12-01

Girolamo Capello, 1487., Venecija, Bib. Del Museo Correr, MS Cl. III. 33 (sl. 15; Commissione del doge Agostino Barbarigo a Paolo di Canale, 1489., Pariz, Bibliothèque Nationale, Lat. 4729, c.2, te Commissione del doge Agostino Barbarigo a Tommaso Loredano, 1490., Pariz, Bibliothèque Nationale, Lat. 4730, c.1. Podudarnosti se mogu pronaći i u iluminacijama Brevijara (oko 1480., Augsburg, Universitätsbibl., Cod. I.2.2o 35 gdje je prvoj stranici lettera istoriata sa umetnutim likom Sv. Pavla karakteristične fizionomije kakvu ima i lik Sv. Aurelija Augustina, te istovjetni likovi anđela u sredini donje margine. Za usporedbu su važne i tri inkunabule iz Padove (Biblioteca del Seminario Vescovile opremljene iluminacijama koje su pripisane Maestru di Pico. Njihove minijature u izvedbi anđela, puttta i svetačkih likova karakterističnih tipologija i pojedinosti kao i tipa dekoracije na marginama također pokazuju izrazite sličnosti sa iluminacijama inkunabule iz Kraja. To su Lattanzijeva Opera (Giovanni da Colonia i Johannes Manthen, Venecija, 1478.; Forc. M. 3.2, Jacopo da Varagine, Legenda aurea (Gabriele di Pietro, Venecija, 1477., uz moguće sudjelovanje radionice; Forc. M. 2.22 i Cipriano, Opera (Vindelino da Spira, Venecija, 1471.; Forc. K. 2.12. Na temelju iznesenih usporednih analiza i uočenih sličnosti može se zaključiti da je iluminacije u inkunabuli De Civitate Dei Sv. Aurelija Augustina (Nicolas Jenson, Venecija, 1475. koja se čuva u samostanu Sv. Duje u Kraju izradio znameniti venecijanski renesansni iluminator Maestro di Pico, pa su one, bez obzira na moguću suradnju radionice i pomoćnika, poglavito u izradi dekorativnog okvira i inicijala, dopuna katalogu njegovih djela ali i dragocjen prilog sveukupnoj slikarskoj baštini iz vremena renesanse u Dalmaciji.

PREFACE: Liquid-solid interfaces: structure and dynamics from spectroscopy and simulations Liquid-solid interfaces: structure and dynamics from spectroscopy and simulations

Science.gov (United States)

Gaigeot, Marie-Pierre; Sulpizi, Marialore

2012-03-01

Ishiyama, Hideaki Takahashi and Akihiro Morita A theoretical study of the sum frequency vibrational spectroscopy of the carbon tetrachloride/water interface Anthony J Green, Angela Perry, Preston B Moore and Brian Space Salt effects on water/hydrophobic liquid interfaces: a molecular dynamics study Chao Zhang and Paolo Carloni Density functional theory-based simulations of sum frequency generation spectra involving methyl stretching vibrations: effect of the molecular model on the deduced molecular orientation and comparison with an analytical approach F Cecchet, D Lis, Y Caudano, A A Mani, A Peremans, B Champagne and J Guthmuller Towards modelling the vibrational signatures of functionalized surfaces: carboxylic acids on H-Si(111) surfaces Conrard Giresse Tetsassi Feugmo, Benoît Champagne, Yves Caudano, Francesca Cecchet, Yves J Chabal and Vincent Liégeois

The Dark Side of Nature: the Crime was Almost Perfect

Science.gov (United States)

2006-12-01

Astrofisico di Arcetri, Italy), Guido Chincarini (INAF, Osservatorio Astronomico di Brera & Università degli Studi di Milano-Bicocca, Italy), Nino Panagia (Space Telescope Science Institute, USA), Gianpiero Tagliaferri, Dino Fugazza, Sergio Campana, Stefano Covino, and Paolo D'Avanzo (INAF, Osservatorio Astronomico di Brera, Italy), Daniele Malesani (SISSA/ISAS, Italy and Dark Cosmology Centre, Copenhagen), Vincenzo Testa, L. Angelo Antonelli, Silvia Piranomonte, and Luigi Stella (INAF, Osservatorio Astronomico di Roma, Italy), Vanessa Mangano (INAF/IASF Palermo, Italy), Kevin Hurley (University of California, Berkeley, USA), I. Felix Mirabel (ESO), and Leonardo J. Pellizza (Instituto de Astronomia y Fisica del Espacio). The Danish-led team is composed of Johan P. U. Fynbo, Darach Watson, Christina C. Thöne, Tamara M. Davis, Jens Hjorth, José Mará Castro Cerón, Brian L. Jensen, Maximilian D. Stritzinger, and Dong Xu (Dark Cosmology Centre, University of Copenhagen, Denmark), Jesper Sollerman (Dark Cosmology Centre and Department of Astronomy, Stockholm University, Sweden), Uffe G. Jørgensen, Tobias C. Hinse, and Kristian G. Woller (Niels Bohr Institute, University of Copenhagen), Joshua S. Bloom, Daniel Kocevski, Daniel Perley (Department of Astronomy, University of California at Berkeley, USA), Páll Jakobsson (Centre for Astrophysics Research, University of Hertfordshire, UK), John F. Graham and Andrew S. Fruchter (Space Telescope Science Institute, Baltimore, USA), David Bersier (Astrophysics Research Institute, Liverpool John Moores University, UK), Lisa Kewley (University of Hawaii, Institute of Astronomy, USA), Arnaud Cassan and Marta Zub (Astronomisches Rechen-Institut, Zentrum für Astronomie der Universität Heidelberg, Germany), Suzanne Foley (School of Physics, University College Dublin, Ireland), Javier Gorosabel (Instituto de Astrofisica de Andalucia, Granada, Spain), Keith D. Horne (SUPA Physics/Astronomy, University of St Andrews, Scotland, UK), Sylvio

EDITORIAL The 17th Central European Workshop on Quantum Optics

Science.gov (United States)

Man'ko, Margarita A.

2011-02-01

-correlation function for graphs with and without time-reversal symmetry: the open system case Michał Ławniczak, Szymon Bauch, Oleh Hul and Leszek Sirko Independent nonclassical tests for states and measurements in the same experiment Alfredo Luis and Ángel Rivas On the classical capacity of quantum Gaussian channels Cosmo Lupo, Stefano Pirandola, Paolo Aniello and Stefano Mancini Entropic inequalities for center-of-mass tomograms Margarita A Man'ko Semiclassical dynamics for an ion confined within a nonlinear electromagnetic trap Bogdan M Mihalcea Zeno-like phenomena in STIRAP processes B Militello, M Scala, A Messina and N V Vitanov A beam splitter with second-order nonlinearity modeled as a nonlinear coupler V Peřinová, A Lukš and J Křepelka Energy-level shifts of a uniformly accelerated atom between two reflecting plates L Rizzuto and S Spagnolo Cross-Kerr nonlinearities in an optically dressed periodic medium K Słowik, A Raczyński, J Zaremba, S Zielińska-Kaniasty, M Artoni and G C La Rocca An approximate effective beamsplitter interaction between light and atomic ensembles Richard Tatham, David Menzies and Natalia Korolkova Stochastic simulation of long-time nonadiabatic dynamics Daniel A Uken, Alessandro Sergi and Francesco Petruccione

List of Participants

Science.gov (United States)

2007-11-01

Ceresole Istituto Nazionale di Fisica Nucleare and Università di Torino Kang Sin Choi University of Bonn Michele Cirafici University of Patras Andres Collinucci Katholieke Universiteit Leuven Aldo Cotrone Universitat de Barcelona Ben Craps Vrije Universiteit, Brussel Stefano Cremonesi SISSA, Trieste Gianguido Dall'Agata Padova University Sanjit Das Indian Institute of Technology, Kharagpur Forcella Davide SISSA, Trieste Jose A de Azcarraga Valencia University and Instituto de Fìsica Corpuscular (CSIC-UVEG), Valencia Sophie de BuylInstitut des Hautes Études Scientifiques, Bures-sur-Yvette Jean-Pierre Derendinger Université de Neuchâtel Stephane Detournay Università Degli Studi di Milano Paolo Di Vecchia NORDITA, København Oscar Dias Universitat de Barcelona Vladimir Dobrev Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Sofia Joel Ekstrand Department of Theoretical Physics, Uppsala University Federico Elmetti Università di Milano I Diaconu Eugen University of Craiova Oleg Evnin Vrije Universiteit, Brussel Bo Feng Imperial College, London Livia Ferro Università di Torino Pau Figueras Universitat de Barcelona Raphael Flauger University of Texas at Austin Valentina Forini Università di Perugia Angelos Fotopoulos Università di Torino Denis Frank Université de Neuchâtel Lisa Freyhult Albert-Einstein-Institut, Golm Carlos Fuertes Instituto de Física Teórica, Madrid Matthias Gaberdiel Eidgenössische Technische Hochschule, Zürich Maria Pilar Garcia del Moral Università di Torino Daniel Gerber Instituto de Física Teórica, Madrid Valentina Giangreco Marotta Puletti Uppsala University Joaquim Gomis Universitat de Barcelona Gianluca Grignani Università di Perugia Luca Griguolo Università di Parma Umut Gursoy École Polytechnique, Palaiseau and École Normale Supérieure, Paris Michael Haack Ludwig-Maximilians-Universität, München Troels Harmark Niels Bohr Institute, København Alexander Haupt Imperial College, London Michal

List of Participants

Science.gov (United States)

2008-11-01

Davide CassaniLaboratoire de Physique Théorique, École Normale Supérieure, Paris Alejandra CastroUniversity of Michigan Claudio Caviezel Max-Planck-Institut für Physik, München Alessio Celi Universitat de Barcelona Anna Ceresole Istituto Nazionale di Fisica Nucleare, Università di Torino Athanasios ChatzistavrakidisNational Technical University of Athens Wissam ChemissanyCentre for Theoretical Physics, University of Groningen Eugen-Mihaita CioroianuUniversity of Craiova Andres CollinucciTechnische Universität Wien Paul CookUniversità di Roma, Tor Vergata Lorenzo CornalbaUniversità di Milano-Bicocca Aldo CotroneKatholieke Universiteit Leuven Ben Craps Vrije Universiteit, Brussel Stefano Cremonesi SISSA, Trieste Riccardo D'AuriaPolitecnico di Torino Gianguido Dall'AgataUniversity of Padova Jose A de AzcarragaUniversidad de Valencia Jan de BoerInstituut voor Theoretische Fysica, Universiteit van Amsterdam Sophie de BuylInstitut des Hautes Études Scientifiques, Bures-sur-Yvette Marius de LeeuwUtrecht University Frederik De RooVrije Universiteit, Brussel Jan De Rydt Katholieke Universiteit Leuven and CERN, Geneva Bernard de WitInstitute for Theoretical Physics, Utrecht University Stephane DetournayIstituto Nazionale di Fisica Nucleare, Sezione di Milano Paolo Di Vecchia Niels Bohr Institute, København Eugen DiaconuUniversity of Craiova Vladimir Dobrev Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Sofia Nick DoreyUniversity of Cambridge Hajar Ebrahim NajafabadiIPM, Tehran Federico Elmetti Università di Milano Oleg Evnin Vrije Universiteit, Brussel Francesco Fiamberti Università di Milano Davide Forcella SISSA, Trieste and CERN, Geneva Valentina Forini Humboldt-Universität zu Berlin Angelos Fotopoulos Università di Torino Denis Frank Université de Neuchâtel Marialuisa Frau Università di Torino Matthias Gaberdiel Eidgenössische Technische Hochschule (ETH), Zürich Diego Gallego SISSA/ISAS, Trieste Maria Pilar Garcia del

PREFACE: XVth International Conference on Calorimetry in High Energy Physics (CALOR2012)

Science.gov (United States)

Akchurin, Nural

2012-12-01

/Saclay Irfu/SPP FRANCAVILLA, Paolo IFAE Barcelona GATAULLIN, Marat California Institute of Technology GATTO, Corrado INFN-Napoli GAUDIO, Gabriella INFN-Pavia GERMANI, Stefano INFN-Perugia Goldenzweig, Pablo University of Rochester GRAF, Norman SLAC National Accelerator Laboratory GROOM, Don Lawrence Berkeley Lab GUARDINCERRI, Elena Los Alamos National Laboratory HAUPTMAN, John Iowa State University HENRIQUES, Ana CERN HUANG, Jin Los Alamos National Laboratory HU, Tao IHEP-Beijing, CAS JIANG, Xiaodong Los Alamos National Laboratory JUI, Charles University of Utah KAPUSTINSKY, Jon Los Alamos National Laboratory KIBILKO, Mark SE Technical Sales, Inc. KIRSCHENMANN, Henning University of Hamburg KISTENEV, Edouard Brookhaven National Laboratory KLIMEK, Pawel Stockholm Universitet KROEGER, Robert University of Mississippi LECOQ, Paul CERN LEE, Sehwook Texas Tech University LEE, Sung-Won Texas Tech University LIVAN, Michele Pavia University LUTZ, Benjamin DESY MAGILL, Stephen Argonne National Laboratory MATHIS, Mark College of William and Mary MATTHEWS, John University of Utah MENKE, Sven Max-Planck-Institut fuer Physik MOULSON, Matthew INFN-Frascati NAGEL, Martin Max-Planck-Institut fuer Physik NAKAMURA, Isamu KEK NEMECEK, Stanislav FZU AVCR Praha NESSI-TEDALDI, Francesca ETH Zurich NOVOTNY, Rainer 2nd Physics Institute, University Giessen OREGLIA, Mark University of Chicago PERLOFF, Alexx Texas A&M University PETYT, David Rutherford Appleton Laboratory RAHMAT, Rahmat University of Mississippi RAMILLI, Marco Hamburg Universitaet ROSIER LEES, Sylvie LAPP- IN2P3-CNRS RUTHERFOORD, John University of Arizona SAKUMA, Tai Texas A&M University SANTIAGO CERQUEIRA, Augusto Federal University of Juiz de Fora SARRA, Ivano INFN-Frascati SEIDEL, Sally University of New Mexico SEIFERT, Frank TU Dresden, Germany SHAMIM, Mansoora University of Oregon SIMON, Frank Max-Planck-Institute for Physics STAFFAN, Paul Wiener Plein and Baus, Corp Dr. STAROVOITOV, Pavel DESY TABARELLI DE FATIS, Tommaso

Chandra and the VLT Jointly Investigate the Cosmic X-Ray Background

Science.gov (United States)

2001-03-01

representative of this elusive class of objects (referred to as ' Type II Quasars ') which are believed to account for approximately 90% of the black-hole-powered quasars in the distant Universe. The 'sum' of the identified Chandra X-ray sources in the CDFS was found to match both the intensity and the spectral properties of the observed X-ray background. This important result is a significant step forward towards the definitive resolution of this long-standing cosmological problem. Naturally, ESO astronomer Piero Rosati and his colleagues are thrilled: " It is clearly the combination of the new and detailed Chandra X-ray observations and the enormous light-gathering power of the VLT that has been instrumental to this success. " However, he says, " the identification of the remaining Chandra X-ray sources will be the next challenge for the VLT since they are extremely faint. This is because they are either heavily obscured by dust or because they are extremely distant ". More Information This Press Release is issued simultaneously with a NASA Press Release (see also the Harvard site ). Some of the first results are described in a research paper ("First Results from the X-ray and Optical Survey of the Chandra Deep Field South" available on the web at astro-ph/0007240. More information about science results from the Chandra X-Ray Observatory may be found at: http://asc.harvard.edu/. The optical survey of CDFS at ESO with the Wide-Field Imager is described in connection with PR Photos 46a-b/99 ('100,000 galaxies at a glance'). An image of the Chandra Deep Field South is available at the ESO website on the EIS Image Gallery webpage. . Notes [1]: The Chandra Team is lead by Riccardo Giacconi (Association of Universities Inc. [AUI], Washington, USA) and includes: Piero Rosati , Jacqueline Bergeron , Roberto Gilmozzi , Vincenzo Mainieri , Peter Shaver (European Southern Observatory [ESO]), Paolo Tozzi , Mario Nonino , Stefano Borgani (Osservatorio Astronomico, Trieste, Italy), Guenther

Ashes from the Elder Brethren

Science.gov (United States)

2001-03-01

based is now in press in the European journal Astronomy & Astrophysics. It is also available on the web as astro-ph/0012457. Notes [1]: 1 billion = 1,000 million. [2]: The team members in the ESO Large Program 165-L0263 devoted to the analysis of globular cluster dwarf stars, described in this Press Release, are: Raffaele Gratton (PI), Eugenio Carretta , Riccardo Claudi , Silvano Desidera , Sara Lucatello (Osservatorio Astronomico di Padova, Italy), Gisella Clementini , Angela Bragaglia (Osservatorio Astronomico di Bologna, Italy), Paolo Molaro , Piercarlo Bonifacio , Miriam Centurion (Osservatorio Astronomico di Trieste, Italy), Francesca D' Antona (Osservatorio Astronomico di Roma, Italy), Vittorio Castellani (Universita' di Pisa, Italy), Alessandro Chieffi (CNR-IAS, Italy), Oscar Straniero (Osservatorio di Teramo, Italy), Luca Pasquini , Patrick Francois (ESO), Francois Spite , Monique Spite (Observatoire de Meudon, France), Chris Sneden (University of Texas at Austin, USA), Frank Grundahl (University of Aarhus, Denmark). [3]: While it is apparent that some mass is transferred from the Planetary Nebulae to the stars, the details of this process are not clear. It may have happened before the stars here observed were formed, or later. In the latter case, the accretion may have occurred only during a particular evolutionary phase, some 100 million years after the cluster formed, i.e. about 11 to 15 billion years ago, and in very dense environments. Moreover, the accretion rate will depend on the relative velocities: only stars that move slowly with respect to the interstellar medium has a good chance of accreting matter. This may also be (part of) an explanation of the observed, large differences from star to star. [4]: A photo of a large planetary nebula is available as PR Photo 38a/98 and information about VLT observations of white dwarf stars in globular clusters are described in PR 20/99. Technical information about the photo PR Photo 06a/01 The image has been

Book Review: Zarzo, E. (2016, Memoria Retórica y Experiencia Estética. Retórica, Estética y Educación. Madrid: Dykinson

Directory of Open Access Journals (Sweden)

Davide Mombelli

2016-10-01

epistemic educational space. It should be noted that said reconstruction closely follows the text, The Art of Memory by Frances Amelia Yates(1966, however, Esther Zarzo’s selection of authors seeks not only to complement the work of Yates by synthesising works of great metaphysical and philosophical depth, such as those by Paolo Rossi(1960, but also to maintain theoretical attention on the substantial change in the conception of memory through the epistemological and metaphysical comparison of the different models, in order to reveal the human dimensions won or lost according to the categorization of the psyche and its social-political impact. The conclusion of the first part of the research reveals that our present is characterized by an atrophy of the mnemonic spiritual operation which, reinforced by the hypertrophy of imagination and taking on a misunderstood fictionalization capacity, leads to the equalization of the internal intentional time to the external reality, which makes the projecting of future experiences on past experiences impossible. With this ability currently underrated because of the semantic shifts derived from the technological paradigm changes, which equate it to the unteachable mechanical memory, it can be said that the art of memory is almost extinct. In this situation, the recovery of a notion of man with the ability to consider his faculties, especially memory, sensitivity and desire, as susceptible to development and as fundamental elements to building his internal time, requires the definition of a notion of experience that allows him to experience this potential and responsibility. Rebuilding a kind of experience that is able to recover this notion of man is the object to which the second part of the research dedicates itself. Consequently, the second part of the research is a reconstruction of contemporary aesthetic thought with regard to aesthetic experience. The reconstruction of a theoretical concept of experience that is an alternative

Macromolecular crowding: chemistry and physics meet biology (Ascona, Switzerland, 10-14 June 2012)

Science.gov (United States)

Foffi, G.; Pastore, A.; Piazza, F.; Temussi, P. A.

2013-08-01

exhaustive chronological account of the major milestones. It is clear that the concept of excluded volume as a key factor remains central to the concept of molecular crowding. As a consequence, simple descriptive paradigms borrowed essentially from colloid physics may still provide useful tools to understand the subtle effects of crowding and confinement in living matter. The contiguity between crowding, colloids and soft matter further emerged as an important concept in the course of the conference in several theoretical lectures and a few experimental ones. Dave Thirumalai, from the University of Maryland (USA), one of the most active theoreticians in the field of theoretical biophysics, outlined scaling theories, concepts from colloid literature and different simulation techniques to describe scenarios for crowding-induced changes in the structure and dynamics of proteins and RNA. In particular, he showed the importance of the shape of crowding particles in affecting folding oligomerization of amyloidogenic peptides. Johannes Schöneberg, from IMPRS, Mathematics Institute (Germany), illustrated ReaDDy , a newly developed particle-based simulation software tool for reaction-diffusion dynamics, developed in the group of Frank Noe at EMPRS. He showed that ReaDDy makes it possible to bridge the gap between soft matter and molecular dynamics (MD) simulations on the one hand and particle-based stochastic reaction-diffusion simulations on the other. We asked Johannes to organize a tutorial session to lead interested participants into the package and 'get their hands wet' under the guidance of the developers. The tutorial session was indeed successful and the broad possibilities offered by the simulation toolkit appeared to be clear to the participants. Paolo De Los Rios, from the Ecole Polytechnique Fédérale de Lausanne (EPFL, Switzerland), examined the complexity of the effects caused by crowding conditions from the point of view of statistical physics. Starting from a

Macromolecular crowding: chemistry and physics meet biology (Ascona, Switzerland, 10-14 June 2012).

Science.gov (United States)

Foffi, G; Pastore, A; Piazza, F; Temussi, P A

2013-08-02

through an exhaustive chronological account of the major milestones. It is clear that the concept of excluded volume as a key factor remains central to the concept of molecular crowding. As a consequence, simple descriptive paradigms borrowed essentially from colloid physics may still provide useful tools to understand the subtle effects of crowding and confinement in living matter. The contiguity between crowding, colloids and soft matter further emerged as an important concept in the course of the conference in several theoretical lectures and a few experimental ones. Dave Thirumalai, from the University of Maryland (USA), one of the most active theoreticians in the field of theoretical biophysics, outlined scaling theories, concepts from colloid literature and different simulation techniques to describe scenarios for crowding-induced changes in the structure and dynamics of proteins and RNA. In particular, he showed the importance of the shape of crowding particles in affecting folding oligomerization of amyloidogenic peptides. Johannes Schöneberg, from IMPRS, Mathematics Institute (Germany), illustrated ReaDDy , a newly developed particle-based simulation software tool for reaction-diffusion dynamics, developed in the group of Frank Noe at EMPRS. He showed that ReaDDy makes it possible to bridge the gap between soft matter and molecular dynamics (MD) simulations on the one hand and particle-based stochastic reaction-diffusion simulations on the other. We asked Johannes to organize a tutorial session to lead interested participants into the package and 'get their hands wet' under the guidance of the developers. The tutorial session was indeed successful and the broad possibilities offered by the simulation toolkit appeared to be clear to the participants. Paolo De Los Rios, from the Ecole Polytechnique Fédérale de Lausanne (EPFL, Switzerland), examined the complexity of the effects caused by crowding conditions from the point of view of statistical physics. Starting