WorldWideScience

Sample records for thermostatically controlled circulation

  1. Room Thermostat with Servo Controlled by PIC Microcontroller

    Directory of Open Access Journals (Sweden)

    Jan Skapa

    2013-01-01

    Full Text Available This paper describes the design of room thermostat with Microchip PIC microcontroller. Thermostat is designated for two-pipe heating system. The microprocessor controls thermostatic valve via electric actuator with mechanical gear unit. The room thermostat uses for its activity measurements of air temperature in the room and calorimetric measurement of heat, which is served to the radiator. These features predestinate it mainly for underfloor heating regulation. The thermostat is designed to work in a network. Communication with heating system's central control unit is proceeded via RS485 bus with proprietary communication protocol. If the communication failure occurs the thermostat is able to work separately. The system uses its own real time clock circuit and memory with heating programs. These programs are able to cover the whole heating season. The method of position discontinuous PSD control is used in this equipment.

  2. RESIDENTIAL THERMOSTATS: COMFORT CONTROLS IN CALIFORNIA HOMES

    Energy Technology Data Exchange (ETDEWEB)

    Meier, Alan K.; Walker, Iain

    2008-03-02

    This report summarizes results of a literature review, a workshop, and many meetings with demand response and thermostat researchers and implementers. The information obtained from these resources was used to identify key issues of thermostat performance from both energy savings and peak demand perspectives. A research plan was developed to address these issues and activities have already begun to pursue the research agenda.

  3. Demand Response on domestic thermostatically controlled loads

    DEFF Research Database (Denmark)

    Lakshmanan, Venkatachalam

    . For a safe and reliable operation of electric power systems, the balance between electricity generation and consumption has to be maintained. The conventional fossil fuel based power generation achieves this balance by adjusting the generation to follow the consumption. In the electric power system......Electricity has become an inevitable part of human life in present day world. In the past two centuries, the electric power system has undergone a lot of changes. Due to the awareness about the adverse impact of the fossil fuels, the power industry is adopting green and sustainable energy sources....... In general, the electricity consumers are classified as industrial, commercial and domestic. In this dissertation, only the thermostatically controlled loads (TCLs) in the domestic segment are considered for the demand response study. The study is funded by Danish Council for Strategic Research (DCSR...

  4. Model predictive control for a thermostatic controlled system

    DEFF Research Database (Denmark)

    Shafiei, Seyed Ehsan; Rasmussen, Henrik; Stoustrup, Jakob

    2013-01-01

    This paper proposes a model predictive control scheme to provide temperature set-points to thermostatic controlled cooling units in refrigeration systems. The control problem is formulated as a convex programming problem to minimize the overall operating cost of the system. The foodstuff temperat......This paper proposes a model predictive control scheme to provide temperature set-points to thermostatic controlled cooling units in refrigeration systems. The control problem is formulated as a convex programming problem to minimize the overall operating cost of the system. The foodstuff...

  5. Optimal daily operation of a smart-household under dynamic pricing considering thermostatically and non-thermostatically controllable appliances

    NARCIS (Netherlands)

    Paterakis, N.G.; Medeiros, M.F.; Catalao, J.P.S.; Siaraka, A.; Bakirtzis, A.G.; Erdinc, O.

    2015-01-01

    In this study, a home energy management system structure is developed in order to determine the optimal commitment of a smart-household. Two types of loads are explicitly modeled: non-thermostatically controllable (electric vehicle, shiftable appliances) and thermostatically controllable loads (air

  6. Energy, Carbon-emission and Financial Savings from Thermostat Control

    Energy Technology Data Exchange (ETDEWEB)

    Blasing, T J [ORNL; Schroeder, Dana [University of Georgia, Athens, GA

    2013-08-01

    Among the easiest approaches to energy, and cost, savings for most people is the adjustment of thermostats to save energy. Here we estimate savings of energy, carbon, and money in the United States of America (USA) that would result from adjusting thermostats in residential and commercial buildings by about half a degree Celsius downward during the heating season and upward during the cooling season. To obtain as small a unit as possible, and therefore the least likely to be noticeable by most people, we selected an adjustment of one degree Fahrenheit (0.56 degree Celsius) which is the gradation used almost exclusively on thermostats in the USA and is the smallest unit of temperature that has been used historically. Heating and/or cooling of interior building space for personal comfort is sometimes referred to as space conditioning, a term we will use for convenience throughout this work without consideration of humidity. Thermostat adjustment, as we use the term here, applies to thermostats that control the indoor temperature, and not to other thermostats such as those on water heaters. We track emissions of carbon only, rather than of carbon dioxide, because carbon atoms change atomic partners as they move through the carbon cycle, from atmosphere to biosphere or ocean and, on longer time scales, through the rock cycle. To convert a mass of carbon to an equivalent mass of carbon dioxide (thereby including the mass of the 2 oxygen atoms in each molecule) simply multiply by 3.67.

  7. Design and Implementation of Frequency-responsive Thermostat Control

    DEFF Research Database (Denmark)

    Nyeng, Preben; Østergaard, Jacob; Togeby, Mikael

    2010-01-01

    properties and needs of each application, and on the other hand the requirements of the system operator. The control algorithms are implemented on a microcontroller unit that is interfaced with existing thermostats for each application. To validate the control algorithms and overall system design, a series...

  8. Economic MPC based on LPV model for thermostatically controlled loads

    DEFF Research Database (Denmark)

    Zemtsov, Nikita; Hlava, Jaroslav; Frantsuzova, Galina

    2017-01-01

    Rapid increase of the renewable energy share in electricity production requires optimization and flexibility of the power consumption side. Thermostatically controlled loads (TCLs) have a large potential for regulation service provision. Economic model predictive control (MPC) is an advanced...... control method which can be used to syncronize the power consumption with undispatchable renewable electricity production. Thermal behavior of TCLs can be described by linear models based on energy balance of the system. In some cases, parameters of the model may be time-varying. In this work, we present...... a modified economic MPC based on linear parameter-varying model. In particular, we provide an exact transformation from a standard economic MPC formulation to a linear program. We assume that the variables influencing the model parameters are known (predictable) for the prediction horizon of the controller...

  9. Hierarchical Control of Thermostatically Controller Loads for Primary Frequency Control

    DEFF Research Database (Denmark)

    Zhao, Haoran; Wu, Qiuwei; Huang, Shaojun

    2016-01-01

    reserve references. At the middle level, distribution substations estimate the available power of TCLs based on the aggregated bin model, and dispatch control signals to individual TCLs. At the local level, a supplementary frequency control loop is implemented at the local controller, which makes TCLs...... respond to the frequency event autonomously. Case studies show that the proposed controller can efficiently respond to frequency events and fulfill the requirement specified by the system operator. The users’ comforts are not compromised and the short cycling of TCLs is largely reduced. Due...... to the autonomous control, the communication requirement is minimized....

  10. Equivalent electricity storage capacity of domestic thermostatically controlled loads

    International Nuclear Information System (INIS)

    Sossan, Fabrizio

    2017-01-01

    A method to quantify the equivalent storage capacity inherent the operation of thermostatically controlled loads (TCLs) is developed. Equivalent storage capacity is defined as the amount of power and electricity consumption which can be deferred or anticipated in time with respect to the baseline consumption (i.e. when no demand side event occurs) without violating temperature limits. The analysis is carried out for 4 common domestic TCLs: an electric space heating system, freezer, fridge, and electric water heater. They are simulated by applying grey-box thermal models identified from measurements. They describe the heat transfer of the considered TCLs as a function of the electric power consumption and environment conditions. To represent typical TCLs operating conditions, Monte Carlo simulations are developed, where models inputs and parameters are sampled from relevant statistical distributions. The analysis provides a way to compare flexible demand against competitive storage technologies. It is intended as a tool for system planners to assess the TCLs potential to support electrical grid operation. In the paper, a comparison of the storage capacity per unit of capital investment cost is performed considering the selected TCLs and two grid-connected battery storage systems (a 720 kVA/500 kWh lithium-ion unit and 15 kVA/120 kWh Vanadium flow redox) is performed. - Highlights: • The equivalent storage capacity of domestic TCLs is quantified • A comparison with battery-based storage technologies is performed • We derive metrics for system planners to plan storage in power system networks • Rule-of-thumb cost indicators for flexible demand and battery-based storage

  11. Design and Modelling of Thermostatically Controlled Loads as Frequency Controlled Reserve

    DEFF Research Database (Denmark)

    Xu, Zhao; Østergaard, Jacob; Togeby, Mikael

    2007-01-01

    Using demand as frequency controlled reserve (DFR) is beneficial to power systems in many aspects. To study the impacts of this technology on power system operation, control logics and simulation models of relevant loads should be carefully developed. Two advanced control logics for using demand...... frequency, is developed. The developed simulation model is able to represent a variety of aggregated thermostatically controlled loads, such as heaters or refrigerators. Uncertainties including customer behaviours and ambient temperature variation are also modelled. Preliminary simulation results...

  12. Control for large scale demand response of thermostatic loads

    DEFF Research Database (Denmark)

    Totu, Luminita Cristiana; Leth, John; Wisniewski, Rafal

    2013-01-01

    appliances with on/off operation. The objective is to reduce the consumption peak of a group of loads composed of both flexible and inflexible units. The power flexible units are the thermostat-based appliances. We discuss a centralized, model predictive approach and a distributed structure with a randomized......Demand response is an important Smart Grid concept that aims at facilitating the integration of volatile energy resources into the electricity grid. This paper considers a residential demand response scenario and specifically looks into the problem of managing a large number thermostatbased...

  13. An Inductive Water Thermostat Using On‐Off Triac Control and Platinum Sensing

    DEFF Research Database (Denmark)

    Diamond, Joseph M.

    1971-01-01

    An on‐off thermostat is described using novel means for heating, sensing, and triac control. Heating is performed by sending the water through a coil of silver tubing which forms the short‐circuited secondary winding of a transformer. This arrangement permits extremely good insulation, which...... was essential in the medical application (a dialysis water thermostat) for which it was designed; its quick response also contributes to the excellent regulation achieved with simple on‐off control. Sensing is provided by a very low resistance platinum coil in direct contact with the water, thus providing quick...

  14. Modeling heterogeneous populations of thermostatically controlled loads using diffusion-advection PDEs

    DEFF Research Database (Denmark)

    Moura, Scott; Ruiz, Victor; Bendtsen, Jan Dimon

    2013-01-01

    This paper focuses on developing a partial differential equation (PDE)-based model and parameter identification scheme for heterogeneous populations of thermostatically controlled loads (TCLs). First, a coupled two-state hyperbolic PDE model for homogenous TCL populations is derived. This model i...

  15. Load management: Model-based control of aggregate power for populations of thermostatically controlled loads

    International Nuclear Information System (INIS)

    Perfumo, Cristian; Kofman, Ernesto; Braslavsky, Julio H.; Ward, John K.

    2012-01-01

    Highlights: ► Characterisation of power response of a population of air conditioners. ► Implementation of demand side management on a group of air conditioners. ► Design of a controller for the power output of a group of air conditioners. ► Quantification of comfort impact of demand side management. - Abstract: Large groups of electrical loads can be controlled as a single entity to reduce their aggregate power demand in the electricity network. This approach, known as load management (LM) or demand response, offers an alternative to the traditional paradigm in the electricity market, where matching supply and demand is achieved solely by regulating how much generation is dispatched. Thermostatically controlled loads (TCLs), such as air conditioners (ACs) and fridges, are particularly suitable for LM, which can be implemented using feedback control techniques to regulate their aggregate power. To achieve high performance, such feedback control techniques require an accurate mathematical model of the TCL aggregate dynamics. Although such models have been developed, they appear too complex to be effectively used in control design. In this paper we develop a mathematical model aimed at the design of a model-based feedback control strategy. The proposed model analytically characterises the aggregate power response of a population of ACs to a simultaneous step change in temperature set points. Based on this model, we then derive, and completely parametrise in terms of the ACs ensemble properties, a reduced-order mathematical model to design an internal-model controller that regulates aggregate power by broadcasting temperature set-point offset changes. The proposed controller achieves high LM performance provided the ACs are equipped with high resolution thermostats. With coarser resolution thermostats, which are typical in present commercial and residential ACs, performance deteriorates significantly. This limitation is overcome by subdividing the population

  16. Generation Following with Thermostatically Controlled Loads via Alternating Direction Method of Multipliers Sharing Algorithm

    OpenAIRE

    Burger, Eric M.; Moura, Scott J.

    2015-01-01

    A fundamental requirement of the electric power system is to maintain a continuous and instantaneous balance between generation and load. The intermittency and uncertainty introduced by renewable energy generation requires the expansion of ancillary power system services to maintain such a balance. In this paper, we examine the potential of thermostatically controlled loads (TCLs), such as refrigerators and electric water heaters, to provide generation following services in real-time energy m...

  17. Thermostatic system of sensor in NIR spectrometer based on PID control

    Science.gov (United States)

    Wang, Zhihong; Qiao, Liwei; Ji, Xufei

    2016-11-01

    Aiming at the shortcomings of the primary sensor thermostatic control system in the near infrared (NIR) spectrometer, a novel thermostatic control system based on proportional-integral-derivative (PID) control technology was developed to improve the detection precision of the NIR spectrometer. There were five parts including bridge amplifier circuit, analog-digital conversion (ADC) circuit, microcontroller, digital-analog conversion (DAC) circuit and drive circuit in the system. The five parts formed a closed-loop control system based on PID algorithm that was used to control the error between the temperature calculated by the sampling data of ADC and the designed temperature to ensure the stability of the spectrometer's sensor. The experimental results show that, when the operating temperature of sensor is -11°, compared with the original system, the temperature control precision of the new control system is improved from ±0.64° to ±0.04° and the spectrum signal to noise ratio (SNR) is improved from 4891 to 5967.

  18. Control characteristics and heating performance analysis of automatic thermostatic valves for radiant slab heating system in residential apartments

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Byung-Cheon [Department of Building Equipment System Engineering, Kyungwon University, Seongnam City (Korea); Song, Jae-Yeob [Graduate School, Building Equipment System Engineering, Kyungwon University, Seongnam City (Korea)

    2010-04-15

    Computer simulations and experiments are carried out to research the control characteristics and heating performances for a radiant slab heating system with automatic thermostatic valves in residential apartments. An electrical equivalent R-C circuit is applied to analyze the unsteady heat transfer in the house. In addition, the radiant heat transfer between slabs, ceilings and walls in the room is evaluated by enclosure analysis method. Results of heating performance and control characteristics were determined from control methods such as automatic thermostatic valves, room air temperature-sensing method, water-temperature-sensing method, proportional control method, and On-Off control method. (author)

  19. Impact of thermostatically controlled loads' demand response activation on aggregated power: A field experiment

    DEFF Research Database (Denmark)

    Lakshmanan, Venkatachalam; Marinelli, Mattia; Kosek, Anna Magdalena

    2015-01-01

    activation. The outcome of this experimental study quantifies the actual flexibility of household TCLs and the consequence for the different parties with respect to power behaviour. Each DR activation method adopts different scenarios to meet the power reduction, and has different impacts on the parameters......This paper describes the impacts of different types of DR (demand response) activation on TCLs' (thermostatically controlled loads) aggregated power. The different parties: power system operators, DR service providers (or aggregators) and consumers, have different objectives in relation to DR....... The experiments are conducted with real domestic refrigerators representing TCL. Activating refrigerators for DR with a delay reduces the ISE (integral square error) in power limitation by 28.46%, overshoot by 7.69%. The delay in refrigerator activation causes reduction in power ramp down rate by 39.90%, ramp up...

  20. Thermostat Controlled Loads Flexibility Assessment for Enabling Load Shifting – An Experimental Proof in a Low Voltage Grid

    DEFF Research Database (Denmark)

    Lakshmanan, Venkatachalam; Marinelli, Mattia; Kosek, Anna M.

    2017-01-01

    This paper investigates the usability of thermostat controlled domestic appliances for load shift in LV distribution grids. The proposed method uses refrigerators for the demonstration of adaptive load prediction to estimate its flexibility and perform scheduling based on load threshold limit. Tw...

  1. Thermostatic Radiator Valve Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Dentz, Jordan [Advanced Residential Integrated Energy Solutions Collaborative, New York, NY (United States); Ansanelli, Eric [Advanced Residential Integrated Energy Solutions Collaborative, New York, NY (United States)

    2015-01-01

    A large stock of multifamily buildings in the Northeast and Midwest are heated by steam distribution systems. Losses from these systems are typically high and a significant number of apartments are overheated much of the time. Thermostatically controlled radiator valves (TRVs) are one potential strategy to combat this problem, but have not been widely accepted by the residential retrofit market.

  2. Safe protocols for generating power pulses with heterogeneous populations of thermostatically controlled loads

    International Nuclear Information System (INIS)

    Sinitsyn, Nikolai A.; Kundu, Soumya; Backhaus, Scott

    2013-01-01

    Highlights: ► Algorithms to produce useful load response from a heterogeneous group of TCLs. ► Generation of sharp power pulses without initiating any unwanted oscillation. ► Open-loop methods, not requiring any detailed system modeling. ► One-way, utility-to-consumer, communication. ► Potential use in secondary frequency regulation, generation-load balancing, etc. - Abstract: We explore methods to use thermostatically controlled loads (TCLs), such as water heaters and air conditioners, to provide ancillary services by assisting in balancing generation and load. We show that by adding simple imbedded instructions and a small amount of memory to temperature controllers of TCLs, it is possible to design open-loop control algorithms capable of creating short-term pulses of demand response without unwanted power oscillations associated with temporary synchronization of the TCL dynamics. By moving a small amount of intelligence to each of the end point TCL devices, we are able to leverage our knowledge of the time dynamics of TCLs to shape the demand response pulses for different power system applications. A significant benefit of our open-loop method is the reduction from two-way to one-way broadcast communication which also eliminates many basic consumer privacy issues. In this work, we focus on developing the algorithms to generate a set of fundamental pulse shapes that can subsequently be used to create demand response with arbitrary profiles. Demand response control methods, such as the one developed here, open the door to fast, nonperturbative control of large aggregations of TCLs

  3. Introducing the ecobee smart thermostat

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    This pamphlet described a thermostat system designed to help households conserve energy and reduce the environmental impacts related to home heating. Features of the ecobee smart thermostat include a weather button that provides the latest forecast for the specific region and a quick save button designed to automatically set the thermostat into an energy conservation mode. A details button provides customer access to all customized heating and cooling settings interfaced in list format. A programming feature assists customers in basic and advanced programming. A vacation setting is also provided to allow customers to save energy while on vacation. The ecobee system uses advanced furnace fan control, ventilator control, and automatic setback calculations. The thermostat system includes a full colour display and integrated web portal designed to allow remote access and provide tools for easily adapting to changing rate structures. Optional broadband connectivity allows real time delivery to customers. The pamphlet also included technical specifications. 1 tab., 9 figs.

  4. Thermostat Interface and Usability: A Survey

    Energy Technology Data Exchange (ETDEWEB)

    Meier, Alan; Peffer, Therese; Pritoni, Marco; Aragon, Cecilia

    2010-09-04

    This report investigates the history of thermostats to better understand the context and legacy regarding the development of this important tool, as well as thermostats' relationships to heating, cooling, and other environmental controls. We analyze the architecture, interfaces, and modes of interaction used by different types of thermostats. For over sixty years, home thermostats have translated occupants' temperature preferences into heating and cooling system operations. In this position of an intermediary, the millions of residential thermostats control almost half of household energy use, which corresponds to about 10percent of the nation's total energy use. Thermostats are currently undergoing rapid development in response to emerging technologies, new consumer and utility demands, and declining manufacturing costs. Energy-efficient homes require more careful balancing of comfort, energy consumption, and health. At the same time, new capabilities will be added to thermostats, including scheduling, control of humidity and ventilation, responsiveness to dynamic electricity prices, and the ability to join communication networks inside homes. Recent studies have found that as many as 50percent of residential programmable thermostats are in permanent"hold" status. Other evaluations found that homes with programmable thermostats consumed more energy than those relying on manual thermostats. Occupants find thermostats cryptic and baffling to operate because manufacturers often rely on obscure, and sometimes even contradictory, terms, symbols, procedures, and icons. It appears that many people are unable to fully exploit even the basic features in today's programmable thermostats, such as setting heating and cooling schedules. It is important that people can easily, reliably, and confidently operate thermostats in their homes so as to remain comfortable while minimizing energy use.

  5. Operation and Management of Thermostatically Controlled Loads for Providing Regulation Services to Power Grids

    Science.gov (United States)

    Vanouni, Maziar

    The notion of demand-side participation in power systems operation and control is on the verge of realization because of the advancement in the required technologies an tools like communications, smart meters, sensor networks, large data management techniques, large scale optimization method, etc. Therefore, demand-response (DR) programs can be one of the prosperous solutions to accommodate part of the increasing demand for load balancing services which is brought about by the high penetration of intermittent renewable energies in power systems. This dissertation studies different aspects of the DR programs that utilized the thermostatically controlled loads (TCLs) to provide load balancing services. The importance of TCLs among the other loads lie on their flexibility in power consumption pattern while the customer/end-user comfort is not (or minimally) impacted. Chapter 2 discussed a previously presented direct load control (DLC) to control the power consumption of aggregated TCLs. The DLC method performs a power tracking control and based on central approach where a central controller broadcasts the control command to the dispersed TCLs to toggle them on/off. The central controller receives measurement feedback from the TCLs once per couple of minutes to run a successful forecast process. The performance evaluation criteria to evaluate the load balancing service provided by the TCLs are presented. The results are discussed under different scenarios and situation. The numerical results show the proper performance of the DLC method. This DLC method is used as the control method in all the studies in this dissertation. Chapter 3 presents performance improvements for the original method in Chapter 2 by communicating two more pieces of information called forecast parameters (FPs). Communicating improves the forecast process in the DLC and hence, both performance accuracy and the amount of tear-and-wear imposed on the TCLs. Chapter 4 formulates a stochastic

  6. Controlled humidity gas circulators

    International Nuclear Information System (INIS)

    Gruner, S.M.

    1981-01-01

    A programmable circulator capable of regulating the humidity of a gas stream over a wide range of humidity is described. An optical dew-point hygrometer is used as a feedback element to control the addition or removal of water vapor. Typical regulation of the gas is to a dew-point temperature of +- 0.2 0 C and to an accuracy limited by the dew-point hygrometer

  7. Fluid circulation control device

    International Nuclear Information System (INIS)

    Benard, Henri; Henocque, Jean.

    1982-01-01

    Horizontal fluid circulation control device, of the type having a pivoting flap. This device is intended for being fitted in the pipes of hydraulic installation, particularly in a bleed and venting system of a nuclear power station shifting radioactive or contaminated liquids. The characteristic of this device is the cut-out at the top of the flap to allow the air contained in the pipes to flow freely [fr

  8. Experimental analysis of flexibility change with different levels of power reduction by demand response activation on thermostat controlled loads

    DEFF Research Database (Denmark)

    Lakshmanan, Venkatachalam; Marinelli, Mattia; Hu, Junjie

    2017-01-01

    This paper studies the flexibility available with thermostatically controlled loads (TCLs) to provide power system services by demand response (DR) activation. Although the DR activation on TCLs can provide power system ancillary services, it is important to know how long such services can...... be provided for when different levels of power reduction are imposed. The flexibility change with different levels of power reduction is tested experimentally with domestic fridges used by real customers with unknown user interaction. The investigation quantifies the flexibility of household fridges...... and the impact of DR activation in terms of deviation in the average temperature. The maximum possible power reduction with the cluster of refrigerators is 67% and the available flexibility with the cluster of refrigerators is 10%. The resulting deviation in the average temperature is 14%....

  9. Controllability and stability of primary frequency control from thermostatic loads with delays

    DEFF Research Database (Denmark)

    Ziras, Charalampos; Vrettos, Evangelos; You, Shi

    2017-01-01

    There is an increasing interest in exploiting the flexibility of loads to provide ancillary services to the grid. In this paper we study how response delays and lockout constraints affect the controllability of an aggregation of refrigerators offering primary frequency control (PFC). First we...... examine the effect of delays in PFC provision from an aggregation of refrigerators, using a two-area power system. We propose a framework to systematically address frequency measurement and response delays and we determine safe values for the total delays via simulations. We introduce a controllability...... index to evaluate PFC provision under lockout constraints of refrigerators compressors. We conduct extensive simulations to study the effects of measurement delay, ramping times, lockout durations and rotational inertia on the controllability of the aggregation and system stability. Finally, we discuss...

  10. Thermostatic Radiator Valve Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Dentz, J. [Advanced Residential Integrated Energy Solutions Collaborative (ARIES), New York, NY (United States); Ansanelli, E. [Advanced Residential Integrated Energy Solutions Collaborative (ARIES), New York, NY (United States)

    2015-01-01

    A large stock of multifamily buildings in the Northeast and Midwest are heated by steam distribution systems. Losses from these systems are typically high and a significant number of apartments are overheated much of the time. Thermostatically controlled radiator valves (TRVs) are one potential strategy to combat this problem, but have not been widely accepted by the residential retrofit market. In this project, the ARIES team sought to better understand the current usage of TRVs by key market players in steam and hot water heating and to conduct limited experiments on the effectiveness of new and old TRVs as a means of controlling space temperatures and reducing heating fuel consumption. The project included a survey of industry professionals, a field experiment comparing old and new TRVs, and cost-benefit modeling analysis using BEopt™ (Building Energy Optimization software).

  11. Field Evaluation of Programmable Thermostats

    Energy Technology Data Exchange (ETDEWEB)

    Sachs, O. [Fraunhofer Center for Sustainable Energy Systems (CSE), Cambridge, MA (United States); Tiefenbeck, V. [Fraunhofer Center for Sustainable Energy Systems (CSE), Cambridge, MA (United States); Duvier, C. [Fraunhofer Center for Sustainable Energy Systems (CSE), Cambridge, MA (United States); Qin, A. [Fraunhofer Center for Sustainable Energy Systems (CSE), Cambridge, MA (United States); Cheney, K. [Fraunhofer Center for Sustainable Energy Systems (CSE), Cambridge, MA (United States); Akers, C. [Fraunhofer Center for Sustainable Energy Systems (CSE), Cambridge, MA (United States); Roth, K. [Fraunhofer Center for Sustainable Energy Systems (CSE), Cambridge, MA (United States)

    2012-12-01

    Prior research suggests that poor programmable thermostats usability may prevent their effective use to save energy. The Fraunhofer team hypothesized that home occupants with high-usability thermostats would be more likely to use them to save energy than people with a basic thermostats. In this report, the team discusses results of a project in which the team monitored and compared programmable thermostats with basic thermostats in an affordable housing apartment complex.

  12. How People Actually Use Thermostats

    Energy Technology Data Exchange (ETDEWEB)

    Meier, Alan; Aragon, Cecilia; Hurwitz, Becky; Mujumdar, Dhawal; Peffer, Therese; Perry, Daniel; Pritoni, Marco

    2010-08-15

    Residential thermostats have been a key element in controlling heating and cooling systems for over sixty years. However, today's modern programmable thermostats (PTs) are complicated and difficult for users to understand, leading to errors in operation and wasted energy. Four separate tests of usability were conducted in preparation for a larger study. These tests included personal interviews, an on-line survey, photographing actual thermostat settings, and measurements of ability to accomplish four tasks related to effective use of a PT. The interviews revealed that many occupants used the PT as an on-off switch and most demonstrated little knowledge of how to operate it. The on-line survey found that 89% of the respondents rarely or never used the PT to set a weekday or weekend program. The photographic survey (in low income homes) found that only 30% of the PTs were actually programmed. In the usability test, we found that we could quantify the difference in usability of two PTs as measured in time to accomplish tasks. Users accomplished the tasks in consistently shorter times with the touchscreen unit than with buttons. None of these studies are representative of the entire population of users but, together, they illustrate the importance of improving user interfaces in PTs.

  13. Active Control of Thermostatic Loads for Economic and Technical Support to Distribution Grids

    DEFF Research Database (Denmark)

    Bhattarai, Bishnu Prasad; Mendaza, Iker Diaz de Cerio; Bak-Jensen, Birgitte

    2016-01-01

    Active control of electric water heaters (EWHs) is presented in this paper as a means of exploiting demand flexibility for supporting low-voltage (LV) distribution grids. A single-node model of an EWH is implemented in DIgSILENT PowerFactory using a thermal energy balancing equation and three...... decentralized control schemes are designed to ensure consumer comfort, economic benefit to the consumer, and technical support to LV grids. First, a price-based control that adaptively adjusts an allowable energy band per electricity price is implemented to ensure economic benefit. Next, an adaptive update...... of the energy band is done based on feeder loading to respect thermal grid constraints. Finally, a voltage-based control is implemented to provide real-time voltage support to the LV grids. Simulation results demonstrate the capability of the presented method to realize both economic and technical advantages...

  14. Texas traffic thermostat marketing package.

    Science.gov (United States)

    2013-04-01

    The traffic thermostat decision tool is built to help guide the user through a logical, step-wise, process of examining potential changes to their Manage Lane/toll facility. : **NOTE: Project Title: Application of the Traffic Thermostat Framework. Ap...

  15. Texas traffic thermostat software tool.

    Science.gov (United States)

    2013-04-01

    The traffic thermostat decision tool is built to help guide the user through a logical, step-wise, process of examining potential changes to their Manage Lane/toll facility. : **NOTE: Project Title: Application of the Traffic Thermostat Framework. Ap...

  16. Field Evaluation of Programmable Thermostats

    Energy Technology Data Exchange (ETDEWEB)

    Sachs, O.; Tiefenbeck, V.; Duvier, C.; Qin, A.; Cheney, K.; Akers, C.; Roth, K.

    2012-12-01

    Prior research suggests that poor programmable thermostats usability may prevent their effective use to save energy. We hypothesized that home occupants with a high-usability thermostats would be more likely to use them to save energy than people with a basic thermostat. We randomly installed a high-usability thermostat in half the 77 apartments of an affordable housing complex, installing a basic thermostat in the other half. During the heating season, we collected space temperature and furnace on-off data to evaluate occupant interaction with the thermostats, foremost nighttime setbacks. We found that thermostat usability did not influence energy-saving behaviors, finding no significant difference in temperature maintained among apartments with high- and low-usability thermostats.

  17. Danfos: Thermostatic Radiator Valves

    DEFF Research Database (Denmark)

    Gregersen, Niels; Oliver, James; Hjorth, Poul G.

    2000-01-01

    This problem deals with modelling the flow through a typical Danfoss thermostatic radiator valve.Danfoss is able to employ Computational Fluid Dynamics (CFD) in calculations of the capacity of valves, but an experienced engineer can often by rules of thumb "guess" the capacity, with a precision...

  18. Cesium heat-pipe thermostat

    Energy Technology Data Exchange (ETDEWEB)

    Wu, F.; Song, D.; Sheng, K.; Wu, J. [Changcheng Institute of Metrology and Measurement, 100095, Beijing (China); Yi, X. [China National South Aviation industry CO., LTD., 412002, Hunan (China); Yu, Z. [Dalian Jinzhou Institute of Measurement and Testing, 116100, Liaoning (China)

    2013-09-11

    In this paper the authors report a newly developed Cesium Heat-Pipe Thermostat (Cs HPT) with the operation range of 400 °C to 800 °C. The working medium is cesium (Cs) of 99.98% purity and contains no radioisotope. A Cs filing device is developed which can prevent Cs being in contact with air. The structural material is stainless steel. A 5000 h test has been made to confirm the compatibility between cesium and stainless steel. The Cs HPT has several thermometer wells of 220mm depth with different diameters for different sizes of thermometers. The temperature uniformity of the Cs HPT is 0.06 °C to 0.20 °C. A precise temperature controller is used to ensure the temperature fluctuation within ±0.03 °C. The size of Cs HPT is 380mm×320mm×280mm with foot wheels for easy moving. The thermostat has been successfully used for the calibration of industrial platinum resistance thermometers and thermocouples.

  19. Thermostatted delta f

    International Nuclear Information System (INIS)

    Krommes, J.A.

    2000-01-01

    The delta f simulation method is revisited. Statistical coarse-graining is used to rigorously derive the equation for the fluctuation delta f in the particle distribution. It is argued that completely collisionless simulation is incompatible with the achievement of true statistically steady states with nonzero turbulent fluxes because the variance of the particle weights w grows with time. To ensure such steady states, it is shown that for dynamically collisionless situations a generalized thermostat or W-stat may be used in lieu of a full collision operator to absorb the flow of entropy to unresolved fine scales in velocity space. The simplest W-stat can be implemented as a self-consistently determined, time-dependent damping applied to w. A precise kinematic analogy to thermostatted nonequilibrium molecular dynamics (NEMD) is pointed out, and the justification of W-stats for simulations of turbulence is discussed. An extrapolation procedure is proposed such that the long-time, steady-state, collisionless flux can be deduced from several short W-statted runs with large effective collisionality, and a numerical demonstration is given

  20. Large Scale Demand Response of Thermostatic Loads

    DEFF Research Database (Denmark)

    Totu, Luminita Cristiana

    This study is concerned with large populations of residential thermostatic loads (e.g. refrigerators, air conditioning or heat pumps). The purpose is to gain control over the aggregate power consumption in order to provide balancing services for the electrical grid. Without affecting the temperat......This study is concerned with large populations of residential thermostatic loads (e.g. refrigerators, air conditioning or heat pumps). The purpose is to gain control over the aggregate power consumption in order to provide balancing services for the electrical grid. Without affecting....... The control architecture is defined by parsimonious communication requirements that also have a high level data privacy, and it furthermore guarantees a robust and secure local operation. Mathematical models are put forward, and the effectiveness is shown by numerical simulations. A case study of 10000...

  1. ENERGY STAR Certified Smart Thermostats

    Data.gov (United States)

    U.S. Environmental Protection Agency — Certified models meet all ENERGY STAR requirements as listed in the Version 1.0 ENERGY STAR Program Requirements for Connected Thermostats that are effective as of...

  2. Investigation of a chaotic thermostat

    Science.gov (United States)

    Morales, G. J.

    2018-03-01

    A numerical study is presented of a free particle interacting with a deterministic thermostat in which the usual friction force is supplemented with a fluctuating force that depends on the self-consistent damping coefficient associated with coupling to the heat bath. It is found that this addition results in a chaotic environment in which a particle self-heats from rest and moves in positive and negative directions, exhibiting a characteristic diffusive behavior. The frequency power spectrum of the dynamical quantities displays the exponential frequency dependence ubiquitous to chaotic dynamics. The velocity distribution function approximates a Maxwellian distribution, but it does show departures from perfect thermal equilibrium, while the distribution function for the damping coefficient shows a closer fit. The behavior for the classic Nosé-Hoover (NH) thermostat is compared to that of the enlarged Martyna-Klein-Tuckerman (MKT) model. Over a narrow amplitude range, the application of a constant external force results quantitatively in the Einstein relation for the NH thermostat, and for the MKT model it differs by a factor of 2.

  3. Time step MOTA thermostat simulation

    International Nuclear Information System (INIS)

    Guthrie, G.L.

    1978-09-01

    The report details the logic, program layout, and operating procedures for the time-step MOTA (Materials Open Test Assembly) thermostat simulation program known as GYRD. It will enable prospective users to understand the operation of the program, run it, and interpret the results. The time-step simulation analysis was the approach chosen to determine the maximum value gain that could be used to minimize steady temperature offset without risking undamped thermal oscillations. The advantage of the GYRD program is that it directly shows hunting, ringing phenomenon, and similar events. Programs BITT and CYLB are faster, but do not directly show ringing time

  4. Testing the effect of defaults on the thermostat settings of OECD employees

    International Nuclear Information System (INIS)

    Brown, Zachary; Johnstone, Nick; Haščič, Ivan; Vong, Laura; Barascud, Francis

    2013-01-01

    We describe a randomized controlled experiment in which the default settings on office thermostats in an OECD office building were manipulated during the winter heating season, and employees' chosen thermostat setting observed over a 6-week period. Using difference-in-differences, panel, and censored regression models (to control for maximum allowable thermostat settings), we find that a 1 °C decrease in the default caused a reduction in the chosen setting by 0.38 °C, on average. Sixty-five percent of this effect could be attributed to office occupant behavior (p-value = 0.044). The difference-in-differences models show that small decreases in the default (1°) led to a greater reduction in chosen settings than large decreases (2°). We also find that office occupants who were more apt to adjust their thermostats prior to the intervention were less susceptible to the default. We conclude that this kind of intervention can increase building-level energy efficiency, and discuss potential explanations and broader policy implications of our findings. - Highlights: • We conduct a randomized controlled trial to test if thermostat defaults affect agent behavior. • Two treatments (schedules of default settings) were tested against a control for 6 weeks at OECD. • Small changes in defaults had a greater effect on chosen settings than larger changes in defaults. • Occupants who frequently changed their thermostats in baseline were less affected by defaults. • Thermostat defaults in office environments can be manipulated to increase energy efficiency

  5. Numerical optimization of circulation control airfoils

    Science.gov (United States)

    Tai, T. C.; Kidwell, G. H., Jr.; Vanderplaats, G. N.

    1981-01-01

    A numerical procedure for optimizing circulation control airfoils, which consists of the coupling of an optimization scheme with a viscous potential flow analysis for blowing jet, is presented. The desired airfoil is defined by a combination of three baseline shapes (cambered ellipse, and cambered ellipse with drooped and spiralled trailing edges). The coefficients of these shapes are used as design variables in the optimization process. Under the constraints of lift augmentation and lift-to-drag ratios, the optimal airfoils are found to lie between those of cambered ellipse and the drooped trailing edge, towards the latter as the angle of attack increases. Results agree qualitatively with available experimental data.

  6. Deterministic time-reversible thermostats: chaos, ergodicity, and the zeroth law of thermodynamics

    Science.gov (United States)

    Patra, Puneet Kumar; Sprott, Julien Clinton; Hoover, William Graham; Griswold Hoover, Carol

    2015-09-01

    The relative stability and ergodicity of deterministic time-reversible thermostats, both singly and in coupled pairs, are assessed through their Lyapunov spectra. Five types of thermostat are coupled to one another through a single Hooke's-law harmonic spring. The resulting dynamics shows that three specific thermostat types, Hoover-Holian, Ju-Bulgac, and Martyna-Klein-Tuckerman, have very similar Lyapunov spectra in their equilibrium four-dimensional phase spaces and when coupled in equilibrium or nonequilibrium pairs. All three of these oscillator-based thermostats are shown to be ergodic, with smooth analytic Gaussian distributions in their extended phase spaces (coordinate, momentum, and two control variables). Evidently these three ergodic and time-reversible thermostat types are particularly useful as statistical-mechanical thermometers and thermostats. Each of them generates Gibbs' universal canonical distribution internally as well as for systems to which they are coupled. Thus they obey the zeroth law of thermodynamics, as a good heat bath should. They also provide dissipative heat flow with relatively small nonlinearity when two or more such temperature baths interact and provide useful deterministic replacements for the stochastic Langevin equation.

  7. Smart Thermostats: An Experimental Facility to Test Their Capabilities and Savings Potential

    Directory of Open Access Journals (Sweden)

    Sergio Bustamante

    2017-08-01

    Full Text Available The European Commission has explained how heating and cooling in buildings and industry account for half of the energy consumption of the EU. Several studies explain how to achieve an energy saving at home, and the use of smart thermostats will help to reduce energy consumption while increasing the efficiency of households. In this article, a comparative evaluation was carried out between four smart thermostats that are now on the market, whose characteristics vary in terms of price, precision of measurements and set temperature, algorithms, etc. A thermal test chamber was designed and constructed from a refrigerator, a thermal blanket, a Raspberry Pi and the necessary electronic components for its control and data collection. From the tests carried out in the thermal chamber, data on the operation of the four thermostats such as the maintenance and the anticipation of the setpoint temperature, were obtained. It was necessary to run the system enough times for each thermostat to memorize the housing characteristics, such as its inertia and its thermal insulation. This would also allow for the generation of a better algorithm to regulate the temperature, which would create a lower oscillation with respect to the setpoint temperature. The learning of the thermostats was not demonstrated and for the anticipation mode it was seen that the thermostats failed to improve or learn in this aspect, as they did not improve the start-up times of the heating system, with the consequent increase in energy consumption.

  8. A Microwave Thermostatic Reactor for Processing Liquid Materials Based on a Heat-Exchanger.

    Science.gov (United States)

    Zhou, Yongqiang; Zhang, Chun; Xie, Tian; Hong, Tao; Zhu, Huacheng; Yang, Yang; Liu, Changjun; Huang, Kama

    2017-10-08

    Microwaves have been widely used in the treatment of different materials. However, the existing adjustable power thermostatic reactors cannot be used to analyze materials characteristics under microwave effects. In this paper, a microwave thermostatic chemical reactor for processing liquid materials is proposed, by controlling the velocity of coolant based on PLC (programmable logic controller) in different liquid under different constant electric field intensity. A nonpolar coolant (Polydimethylsiloxane), which is completely microwave transparent, is employed to cool the liquid materials. Experiments are performed to measure the liquid temperature using optical fibers, the results show that the precision of temperature control is at the range of ±0.5 °C. Compared with the adjustable power thermostatic control system, the effect of electric field changes on material properties are avoided and it also can be used to detect the properties of liquid materials and special microwave effects.

  9. Performance of Control System Using Microcontroller for Sea Water Circulation

    Science.gov (United States)

    Indriani, A.; Witanto, Y.; Pratama, A. S.; Supriyadi; Hendra; Tanjung, A.

    2018-02-01

    Now a day control system is very important rule for any process. Control system have been used in the automatic system. Automatic system can be seen in the industrial filed, mechanical field, electrical field and etc. In industrial and mechanical field, control system are used for control of motion component such as motor, conveyor, machine, control of process made of product, control of system and soon. In electrical field, control system can met for control of electrical system as equipment or part electrical like fan, rice cooker, refrigerator, air conditioner and etc. Control system are used for control of temperature and circulation gas, air and water. Control system of temperature and circulation of water also can be used for fisher community. Control system can be create by using microcontroller, PLC and other automatic program [1][2]. In this paper we will focus on the close loop system by using microcontroller Arduino Mega to control of temperature and circulation of sea water for fisher community. Performance control system is influenced by control equipment, sensor sensitivity, test condition, environment and others. The temperature sensor is measured using the DS18S20 and the sea water clarity sensor for circulation indicator with turbidity sensor. From the test results indicated that this control system can circulate sea water and maintain the temperature and clarity of seawater in a short time.

  10. Efficient stochastic thermostatting of path integral molecular dynamics.

    Science.gov (United States)

    Ceriotti, Michele; Parrinello, Michele; Markland, Thomas E; Manolopoulos, David E

    2010-09-28

    The path integral molecular dynamics (PIMD) method provides a convenient way to compute the quantum mechanical structural and thermodynamic properties of condensed phase systems at the expense of introducing an additional set of high frequency normal modes on top of the physical vibrations of the system. Efficiently sampling such a wide range of frequencies provides a considerable thermostatting challenge. Here we introduce a simple stochastic path integral Langevin equation (PILE) thermostat which exploits an analytic knowledge of the free path integral normal mode frequencies. We also apply a recently developed colored noise thermostat based on a generalized Langevin equation (GLE), which automatically achieves a similar, frequency-optimized sampling. The sampling efficiencies of these thermostats are compared with that of the more conventional Nosé-Hoover chain (NHC) thermostat for a number of physically relevant properties of the liquid water and hydrogen-in-palladium systems. In nearly every case, the new PILE thermostat is found to perform just as well as the NHC thermostat while allowing for a computationally more efficient implementation. The GLE thermostat also proves to be very robust delivering a near-optimum sampling efficiency in all of the cases considered. We suspect that these simple stochastic thermostats will therefore find useful application in many future PIMD simulations.

  11. Peltier battery thermostat for semiconductor detectors

    International Nuclear Information System (INIS)

    Caini, V.

    1980-01-01

    The description is given of a Peltier battery cooling thermostat for semiconductor detectors, whose sensing element is the detector itself. A signal proportional to the leakage current is amplified and compared with a chosen reference voltage. The difference, amplified and sensed, regulates the cooling current to the Peltier battery. Special mechanical devices speed up measurement-taking. The leakage current proved to be reducible to as little as 1/1000 of that at ambient temperature and the stabilization obtained is between +-5 nA (although between +-1 nA is also feasible). Hence it is possible to use very high load resistance preamplifiers to reduce noise and to improve stability and pulse height resolution in α spectroscopy, even with a detector unsuitable for work at very low temperatures. Other applications can be foreseen. (orig.)

  12. Wake characterization methods of a circulation control wing

    Science.gov (United States)

    El Sayed Mohamed, Y.; Semaan, R.; Sattler, S.; Radespiel, R.

    2017-10-01

    We propose a three-pronged methodology to characterise the wake behind a circulation control wing. The study relies on time-resolved particle image velocimetry (TR-PIV) measurements in a water tunnel for a range of blowing intensities. The first method is the well-known proper orthogonal decomposition (POD). The second tool is a new implementation of the power spectrum. Finally, a modified Q-criterion vortex detection and quantification method is presented. The results show the complementary advantage of the three methods in analysing wake flows with varying conditions.

  13. Fast betatron tune controller for circulating beam in a synchrotron

    International Nuclear Information System (INIS)

    Endo, Takuyuki; Hatanaka, Kichiji; Sato, Kenji

    1997-01-01

    When rf quadrupole (RFQ) electric field is applied to the circulating beam in a synchrotron, an equation of motion is reduced to Mathieu's Equation. A new analytical method to obtain an approximate solution has been developed, while a numerical computation was usually applied. Translating the behavior of approximate solution into terms of an RFQ electric field and betatron oscillation, a fast tune control can be achieved by rapid tuning of both amplitude and frequency of rf voltage. This process could be applied to suppress a tune shift caused by a space charge effect and to control a slow beam extraction with a low ripple. We have started another analytical computation using Hamiltonian with perturbation of RFQ and the results of this computation also suggest that it is applicable to slow beam extraction. The fast tune controller has been constructed and the beam test will be performed at HIMAC synchrotron in cooperation of RCNP and NIRS. (author)

  14. New Approaches to Circulating Current Controllers for Modular Multilevel Converters

    Directory of Open Access Journals (Sweden)

    Miguel Moranchel

    2017-01-01

    Full Text Available In the next years, modular multilevel converters (MMCs are going to be a next generation multilevel converters for medium to high voltage conversion applications, such as medium voltage motor drives, medium voltage flexible AC transmission systems (FACTS and high voltage direct current transmission. They provide advantages such as high modularity, availability, low generation of harmonics, etc. However, the circulating current distorts the leg currents and increases the rated current of power devices, which further increases system cost. This paper focuses on analysis and suppression of these currents in a MMC using two algorithms for tracking of harmonics. For this work resonant controllers and repetitive controllers have been selected. Both controllers are analyzed and simulations results are presented. Moreover, the controllers have been tested and validated for a three phase MMC operating as an inverter using a real processing platform based on Zynq by Xilinx and designed to control large multilevel converters and in a real MMC prototype. These results are provided to demonstrate the feasibility of the proposed method.

  15. Numerical optimization of circulation control airfoil at high subsonic speed

    Science.gov (United States)

    Tai, T. C.; Kidwell, G. H., Jr.

    1984-01-01

    A numerical procedure for optimizing the design of the circulation control airfoil for use at high subsonic speeds is presented. The procedure consists of an optimization scheme coupled with a viscous potential flow analysis for the blowing jet. The desired airfoil is defined by a combination of three baseline shapes (cambered ellipse and cambered ellipse with drooped and spiraled trailing edges). The coefficients of these shapes are used as design variables in the optimization process. Under the constraints of lift augmentation and lift-to-drag ratios, the airfoil, optimized at free-stream Mach 0.54 and alpha = -2 degrees can be characterized as a cambered ellipse with a drooped trailing edge. Experimental tests support the performance improvement predicted by numerical optimization.

  16. Unsteady flow model for circulation-control airfoils

    Science.gov (United States)

    Rao, B. M.

    1979-01-01

    An analysis and a numerical lifting surface method are developed for predicting the unsteady airloads on two-dimensional circulation control airfoils in incompressible flow. The analysis and the computer program are validated by correlating the computed unsteady airloads with test data and also with other theoretical solutions. Additionally, a mathematical model for predicting the bending-torsion flutter of a two-dimensional airfoil (a reference section of a wing or rotor blade) and a computer program using an iterative scheme are developed. The flutter program has a provision for using the CC airfoil airloads program or the Theodorsen hard flap solution to compute the unsteady lift and moment used in the flutter equations. The adopted mathematical model and the iterative scheme are used to perform a flutter analysis of a typical CC rotor blade reference section. The program seems to work well within the basic assumption of the incompressible flow.

  17. DBSSP - A computer program for simulation of controlled circulation boiler and natural circulation boiler start up behavior

    International Nuclear Information System (INIS)

    Li Bin; Chen Tingkuan; Yang Dong

    2005-01-01

    In this paper, a computer program, Drum Boiler Start-up Simulation Program (DBSSP), is developed for simulating the start up behavior of controlled circulation and natural circulation boilers. The mathematical model developed here is based on the first principles of mass, energy and momentum conservations. In the boiler model, heat transfer in the waterwall, the superheater, the reheater and the economizer is simulated by the distributing parameter method, while heat transfer in the drum and the downcomer is simulated by lumped parameter analysis. The program can provide detailed flow and thermodynamic characteristics of the boiler components. The development of this program is based only on design data, so it can be used for any subcritical, controlled or natural circulation boiler. The simulation results were compared with experimental measurements, and good agreements between them were found. This program is expected to be useful for predicting the characteristics and the performance of controlled circulation and natural circulation boilers during the start up process. It also can be used to optimize a start up system for minimum start up time

  18. A Coordinate Control Strategy for Circulating Current Suppression in Multiparalleled Three-Phase Inverters

    DEFF Research Database (Denmark)

    Zhang, Xueguang; Wang, Tianyi; Wang, Xiongfei

    2017-01-01

    This paper addresses the zero-sequence circulating current control in the multiparalleled three-phase voltage-source inverters. The model of the zero-sequence circulating current in the N-paralleled (N ≥ 3) inverters is derived. It is shown that the circulating current is not only susceptible...... to the mismatches of circuit parameters, but it is also influenced by the interactions of circulating current controllers used by other paralleled inverters. To eliminate these adverse effects on the circulating current control loop, a coordinate control strategy for the N-paralleled inverter is proposed based...... on the zero-vector feedforward method with the space-vector pulse width modulation. Moreover, a virtual inverter method is introduced to facilitate the implementation of the proposed controller, which decouples the interactions of circulating current controllers in the paralleled inverters. Finally...

  19. Application of Circulation Controlled Blades for Vertical Axis Wind Turbines

    Directory of Open Access Journals (Sweden)

    Velissarios Kourkoulis

    2013-07-01

    Full Text Available The blades of a vertical axis wind turbine (VAWT rotor see an inconsistent angle of attack through its rotation. Consequently, VAWT blades generally use symmetrical aerofoils with a lower lift-to-drag ratio than cambered aerofoils tailored to maximise horizontal axis wind turbine rotor performance. This paper considers the feasibility of circulation controlled (CC VAWT blades, using a tangential air jet to provide lift and therefore power augmentation. However CC blade sections require a higher trailing-edge thickness than conventional sections giving rise to additional base drag. The choice of design parameters is a compromise between lift augmentation, additional base drag as well as the power required to pump the air jet. Although CC technology has been investigated for many years, particularly for aerospace applications, few researchers have considered VAWT applications. This paper considers the feasibility of the technology, using Computational Fluid Dynamics to evaluate a baseline CC aerofoil with different trailing-edge ellipse shapes. Lift and drag increments due to CC are considered within a momentum based turbine model to determine net power production. The study found that for modest momentum coefficients significant net power augmentation can be achieved with a relatively simple aerofoil geometry if blowing is controlled through the blades rotation.

  20. Modeling Populations of Thermostatic Loads with Switching Rate Actuation

    DEFF Research Database (Denmark)

    Totu, Luminita Cristiana; Wisniewski, Rafal; Leth, John-Josef

    2015-01-01

    We model thermostatic devices using a stochastic hybrid description, and introduce an external actuation mechanism that creates random switch events in the discrete dynamics. We then conjecture the form of the Fokker-Planck equation and successfully verify it numerically using Monte Carlo...... simulations. The actuation mechanism and subsequent modeling result are relevant for power system operation....

  1. The circulation of Amway's discourse: from control to social practice

    OpenAIRE

    Brunelli, Anna Flora

    2013-01-01

    In this paper, we intend to contribute to the debate about the circulation of the discourses. To do that, we analyze aspects regarding the circulation of Amway's discourse, a North-American network sales company that has been working in Brazil for a while. Precisely, we analyze the conditions of this circulation at the time it was more intensively, ie, in the 90s, when there were thousands of people in several parts of the country selling the company's products or consuming them. This study h...

  2. Development of modular thermostatic vapour-cooled current leads for cryogenic service

    International Nuclear Information System (INIS)

    Blessing, H.; Lebrun, P.

    1983-01-01

    Cryogenic current leads cooled by helium vapour have been developed, built and tested. Their construction, based on standard electrolytic copper braids crimped at the ends, is such as to provide flexible cold terminations and make possible a modular design. The warm terminations combine electrical insulation, leak-tightness and integrated thermostatic valves controlling lead temperature and avoiding thermal run-away or ice build-up. After giving a detailed description of their construction, this report presents results of performance and reliability tests made on prototype units. (orig.)

  3. Indirect thermal control for improved reliability of Modular Multilevel Converter by utilizing circulating current

    DEFF Research Database (Denmark)

    Dowlatabadi, Mohammadkazem Bakhshizadeh; Ma, Ke; Loh, Poh Chiang

    2015-01-01

    semiconductor devices are comprehensively investigated. Also a novel control strategy by utilizing the circulating current is proposed to enhance the reliability performance of MMC in order to limit the amplitude of thermal cycles. It is concluded that the circulating current may change the losses and thermal...

  4. Construction and Start-up of a Large-Volume Thermostat for Dielectric-Constant Gas Thermometry

    Science.gov (United States)

    Merlone, A.; Moro, F.; Zandt, T.; Gaiser, C.; Fellmuth, B.

    2010-07-01

    A liquid-bath thermostat with a volume of about 800 L was designed to provide a suitable thermal environment for a dielectric-constant gas thermometer (DCGT) in the range from the triple point of mercury to the melting point of gallium. In the article, results obtained with the unique, huge thermostat without the DCGT measuring chamber are reported to demonstrate the capability of controlling the temperature of very large systems at a metrological level. First tests showed that the bath together with its temperature controller provide a temperature variation of less than ±0.5mK peak-to-peak. This temperature instability could be maintained over a period of several days. In the central working volume (diameter—500mm, height—650mm), in which the vacuum chamber containing the measuring system of the DCGT will be placed later, the temperature inhomogeneity has been demonstrated to be also well below 1mK.

  5. A Wind Tunnel Model to Explore Unsteady Circulation Control for General Aviation Applications

    Science.gov (United States)

    Cagle, Christopher M.; Jones, Gregory S.

    2002-01-01

    Circulation Control airfoils have been demonstrated to provide substantial improvements in lift over conventional airfoils. The General Aviation Circular Control model is an attempt to address some of the concerns of this technique. The primary focus is to substantially reduce the amount of air mass flow by implementing unsteady flow. This paper describes a wind tunnel model that implements unsteady circulation control by pulsing internal pneumatic valves and details some preliminary results from the first test entry.

  6. Mechatronic thermostatic water mixer for building automation

    Directory of Open Access Journals (Sweden)

    Stefano Mauro

    2015-05-01

    Full Text Available The use of sanitary water is a main aspect of comfort and healthiness within a house or a public environment as gyms or beauty farms. At the same time, water waste should be limited to a minimum in order to preserve both water and the energy required to warm it. To obtain these results, it is necessary to rule quickly and in a precise way the temperature. It is also necessary to check the presence of possible contemporary flow requested by different users in order to optimize distribution in the house network. This work describes a mechatronic water mixer that was developed to ensure fast and precise control of flow and temperature of delivered water. The flow control is based on modulating digital valves driven in pulse code modulation and on a microcontroller board. The electronic unit is designed to interface with a domotic network for remote control and total consumption monitoring and optimization.

  7. Automated Book Order and Circulation Control Procedures at the Oakland University Library

    Directory of Open Access Journals (Sweden)

    Lawrence Auld

    1968-05-01

    Full Text Available Automated systems of book order and circulation control using an IBM 1620 Computer are described as developed at Oakland University. Relative degrees of success and failure are discussed briefly.

  8. Proceedings of the 2004 NASA/ONR Circulation Control Workshop, Part 1

    Science.gov (United States)

    Jones, Gregory S. (Editor); Joslin, Ronald D. (Editor)

    2005-01-01

    As technological advances influence the efficiency and effectiveness of aerodynamic and hydrodynamic applications, designs and operations, this workshop was intended to address the technologies, systems, challenges and successes specific to Coanda driven circulation control in aerodynamics and hydrodynamics. A major goal of this workshop was to determine the 2004 state-of-the-art in circulation control and understand the roadblocks to its application. The workshop addressed applications, CFD, and experiments related to circulation control, emphasizing fundamental physics, systems analysis, and applied research. The workshop consisted of 34 single session oral presentations and written papers that focused on Naval hydrodynamic vehicles (e.g. submarines), Fixed Wing Aviation, V/STOL platforms, propulsion systems (including wind turbine systems), ground vehicles (automotive and trucks) and miscellaneous applications (e.g., poultry exhaust systems and vacuum systems). Several advanced CFD codes were benchmarked using a two-dimensional NCCR circulation control airfoil. The CFD efforts highlighted inconsistencies in turbulence modeling, separation and performance predictions.

  9. Computer Assisted Circulation Control at Health Sciences Library SUNYAB

    Directory of Open Access Journals (Sweden)

    Jean K. Miller

    1972-06-01

    Full Text Available A description of the circulation system which the Health Sciences Library at the State University of New York at Buffalo has been using since October 1970. Features of the system include automatic production of overdue, fine, and billing notices; notices for call-in of requested books; and book availability notices. Remote operation and processing on the IBM 360/40 and CDC 6400 computer are accomplished via the Administrative Terminal System (ATS and Terminal job Entry (T]E. The system provides information for management of the collection and improved service to the user.

  10. Application of Circulation Control Technology to Airframe Noise Reduction

    Science.gov (United States)

    Ahuja, K. K.; Sankar, L. N.; Englar, R. J.; Munro, Scott E.; Li, Yi; Gaeta, R. J.

    2003-01-01

    This report is a summary of the work performed by Georgia Tech Research Institute (GTRI) under NASA Langley Grant NAG-1-2146, which was awarded as a part of NASA's Breakthrough Innovative Technologies (BIT) initiative. This was a three-year program, with a one-year no-cost extension. Each year's study has been an integrated effort consisting of computational fluid dynamics, experimental aerodynamics, and detailed noise and flow measurements. Year I effort examined the feasibility of reducing airframe noise by replacing the conventional wing systems with a Circulation Control Wing (CCW), where steady blowing was used through the trailing edge of the wing over a Coanda surface. It was shown that the wing lift increases with CCW blowing and indeed for the same lift, a CCW wing was shown to produce less noise. Year 2 effort dealt with a similar study on the role of pulsed blowing on airframe noise. The main objective of this portion of the study was to assess whether pulse blowing from the trailing edge of a CCW resulted in more, less, or the same amount of radiated noise to the farfield. Results show that a reduction in farfield noise of up to 5 dB is measured when pulse flow is compared with steady flow for an equivalent lift configuration. This reduction is in the spectral region associated with the trailing edge jet noise. This result is due to the unique advantage that pulsed flow has over steady flow. For a range of frequencies, more lift is experienced with the same mass flow as the steady case. Thus, for an equivalent lift and slot height, the pulsed system can operate at lower jet velocities, and hence lower jet noise. The computational analysis showed that for a given time-averaged mass flow rate, pulsed jets give a higher value of C(sub l) and a higher L/D than equivalent steady jets. This benefit is attributable to higher instantaneous jet velocities, and higher instantaneous C(sub mu) values for the pulsed jet. Pulsed jet benefits increase at higher

  11. Control of the Bed Temperature of a Circulating Fluidized Bed Boiler by using Particle Swarm Optimization

    Directory of Open Access Journals (Sweden)

    AYGUN, H.

    2012-05-01

    Full Text Available Circulating fluidized bed boilers are increasingly used in the power generation due to their higher combustion efficiency and lower pollutant emissions. Such boilers require an effective control of the bed temperature, because it influences the boiler combustion efficiency and the rate of harmful emissions. A Particle-Swarm-Optimization-Proportional-Integrative-Derivative (PSO-PID controller for the bed temperature of a circulating fluidized bed boiler is presented. In order to prove the capability of the proposed controller, its performances are compared at different boiler loads with those of a Fuzzy Logic (FL controller. The simulation results demonstrate some advantages of the proposed controller.

  12. From the Conception to the Marketing of a New Automatic Control

    DEFF Research Database (Denmark)

    Nielsen, Peter V.; Kildegaard, Erik; Boel, Jan

    1985-01-01

    From a historical viewpoint, product technology has developed via radiator thermostats, return thermostats and selfacting automatic temperature and pressure controls towards more integrated automatic control systems also including weather compensators, which offer benefits in the form of energy...

  13. Glacial greenhouse-gas fluctuations controlled by ocean circulation changes.

    Science.gov (United States)

    Schmittner, Andreas; Galbraith, Eric D

    2008-11-20

    Earth's climate and the concentrations of the atmospheric greenhouse gases carbon dioxide (CO(2)) and nitrous oxide (N(2)O) varied strongly on millennial timescales during past glacial periods. Large and rapid warming events in Greenland and the North Atlantic were followed by more gradual cooling, and are highly correlated with fluctuations of N(2)O as recorded in ice cores. Antarctic temperature variations, on the other hand, were smaller and more gradual, showed warming during the Greenland cold phase and cooling while the North Atlantic was warm, and were highly correlated with fluctuations in CO(2). Abrupt changes in the Atlantic meridional overturning circulation (AMOC) have often been invoked to explain the physical characteristics of these Dansgaard-Oeschger climate oscillations, but the mechanisms for the greenhouse-gas variations and their linkage to the AMOC have remained unclear. Here we present simulations with a coupled model of glacial climate and biogeochemical cycles, forced only with changes in the AMOC. The model simultaneously reproduces characteristic features of the Dansgaard-Oeschger temperature, as well as CO(2) and N(2)O fluctuations. Despite significant changes in the land carbon inventory, CO(2) variations on millennial timescales are dominated by slow changes in the deep ocean inventory of biologically sequestered carbon and are correlated with Antarctic temperature and Southern Ocean stratification. In contrast, N(2)O co-varies more rapidly with Greenland temperatures owing to fast adjustments of the thermocline oxygen budget. These results suggest that ocean circulation changes were the primary mechanism that drove glacial CO(2) and N(2)O fluctuations on millennial timescales.

  14. Model-free adaptive control of supercritical circulating fluidized-bed boilers

    Science.gov (United States)

    Cheng, George Shu-Xing; Mulkey, Steven L

    2014-12-16

    A novel 3-Input-3-Output (3.times.3) Fuel-Air Ratio Model-Free Adaptive (MFA) controller is introduced, which can effectively control key process variables including Bed Temperature, Excess O2, and Furnace Negative Pressure of combustion processes of advanced boilers. A novel 7-input-7-output (7.times.7) MFA control system is also described for controlling a combined 3-Input-3-Output (3.times.3) process of Boiler-Turbine-Generator (BTG) units and a 5.times.5 CFB combustion process of advanced boilers. Those boilers include Circulating Fluidized-Bed (CFB) Boilers and Once-Through Supercritical Circulating Fluidized-Bed (OTSC CFB) Boilers.

  15. Customized Internal Reference Controls for Improved Assessment of Circulating MicroRNAs in Disease.

    Directory of Open Access Journals (Sweden)

    Kenny Schlosser

    Full Text Available Altered levels of circulating extracellular miRNA in plasma and serum have shown promise as non-invasive biomarkers of disease. However, unlike the assessment of cellular miRNA levels for which there are accepted housekeeping genes, analogous reference controls for normalization of circulating miRNA are lacking. Here, we provide an approach to identify and validate circulating miRNA reference controls on a de novo basis, and demonstrate the advantages of these customized internal controls in different disease settings. Importantly, these internal controls overcome key limitations of external spike-in controls.Using a global RT-qPCR screen of 1066 miRNAs in plasma from pulmonary hypertension patients (PAH and healthy subjects as a case example, we identified a large pool of initial candidate miRNAs that were systematically ranked according to their plasma level stability using a predefined algorithm. The performance of the top candidates was validated against multiple comparators, and in a second independent cohort of PAH and control subjects. The broader utility of this approach was demonstrated in a completely different disease setting with 372 miRNAs screened in plasma from septic shock patients and healthy controls.Normalization of data with specific internal reference controls significantly reduced the overall variation in circulating miRNA levels between subjects (relative to raw data, provided a more balanced distribution of up- and down-regulated miRNAs, replicated the results obtained by the benchmark geometric averaging of all detected miRNAs, and outperformed the commonly used external spike-in strategy.We demonstrate the feasibility of identifying circulating reference controls that can reduce extraneous technical variations, and improve the assessment of disease-related changes in plasma miRNA levels. This study provides a novel conceptual framework that addresses a critical and previously unmet need if circulating miRNAs are to

  16. High-Reynolds Number Circulation Control Testing in the National Transonic Facility

    Science.gov (United States)

    Milholen, William E., II; Jones, Gregory S.; Chan, David T.; Goodliff, Scott L.

    2012-01-01

    A new capability to test active flow control concepts and propulsion simulations at high Reynolds numbers in the National Transonic Facility at the NASA Langley Research Center is being developed. The first active flow control experiment was completed using the new FAST-MAC semi-span model to study Reynolds number scaling effects for several circulation control concepts. Testing was conducted over a wide range of Mach numbers, up to chord Reynolds numbers of 30 million. The model was equipped with four onboard flow control valves allowing independent control of the circulation control plenums, which were directed over a 15% chord simple-hinged flap. Preliminary analysis of the uncorrected lift data showed that the circulation control increased the low-speed maximum lift coefficient by 33%. At transonic speeds, the circulation control was capable of positively altering the shockwave pattern on the upper wing surface and reducing flow separation. Furthermore, application of the technique to only the outboard portion of the wing demonstrated the feasibility of a pneumatic based roll control capability.

  17. Identification and MPC control of a circulation fluidized bed boiler using an LPV model

    NARCIS (Netherlands)

    Huang, J.; Ji, G.; Zhu, Y.; Lin, W.; Kothare, M.; Tade, M.; Vande Wouwer, A.; Smets, I.

    2010-01-01

    This work studies the identification and control of circulation fluidized bed (CFB) boilers. The CFB boiler under investigation shows strong nonlinearity due to big changes of steam load. A linear parameter varying (LPV) model is used to represent the process dynamics and used in control. The steam

  18. The computation of the post-stall behavior of a circulation controlled airfoil

    Science.gov (United States)

    Linton, Samuel W.

    1993-01-01

    The physics of the circulation controlled airfoil is complex and poorly understood, particularly with regards to jet stall, which is the eventual breakdown of lift augmentation by the jet at some sufficiently high blowing rate. The present paper describes the numerical simulation of stalled and unstalled flows over a two-dimensional circulation controlled airfoil using a fully implicit Navier-Stokes code, and the comparison with experimental results. Mach numbers of 0.3 and 0.5 and jet total to freestream pressure ratios of 1.4 and 1.8 are investigated. The Baldwin-Lomax and k-epsilon turbulence models are used, each modified to include the effect of strong streamline curvature. The numerical solutions of the post-stall circulation controlled airfoil show a highly regular unsteady periodic flowfield. This is the result of an alternation between adverse pressure gradient and shock induced separation of the boundary layer on the airfoil trailing edge.

  19. A sensorless control method for capacitor voltage balance and circulating current suppression of modular multilevel converter

    DEFF Research Database (Denmark)

    Liu, Hui; Ma, Ke; Loh, Poh Chiang

    2015-01-01

    There are several problems in the Modular Multilevel Converter (MMC), such as the appearance of circulating current, capacitor voltage unbalance and the requirement for a high number of sensors. All these problems will decrease the reliability and raise the cost/uncertainty of using MMC solutions....... As a result, a sensorless control method is proposed in this paper, which targets to improve the performances of MMC in respect to the above mentioned disadvantages: To decrease the cost and simplify the physical implementation, a state observer is proposed and designed to estimate both the capacitor voltages...... and the circulating currents in order to replace the high numbers of sensors. Furthermore, a control method combining the circulating current suppression and the capacitor voltage balancing is conducted based on the proposed state observer. It is concluded that the proposed state observer and control method can...

  20. Small Business Demand Response with Communicating Thermostats: SMUD's Summer Solutions Research Pilot

    Energy Technology Data Exchange (ETDEWEB)

    Herter, Karen; Wayland, Seth; Rasin, Josh

    2009-09-25

    This report documents a field study of 78 small commercial customers in the Sacramento Municipal Utility District service territory who volunteered for an integrated energy-efficiency/demand-response (EE-DR) program in the summer of 2008. The original objective for the pilot was to provide a better understanding of demand response issues in the small commercial sector. Early findings justified a focus on offering small businesses (1) help with the energy efficiency of their buildings in exchange for occasional load shed, and (2) a portfolio of options to meet the needs of a diverse customer sector. To meet these expressed needs, the research pilot provided on-site energy efficiency advice and offered participants several program options, including the choice of either a dynamic rate or monthly payment for air-conditioning setpoint control. An analysis of hourly load data indicates that the offices and retail stores in our sample provided significant demand response, while the restaurants did not. Thermostat data provides further evidence that restaurants attempted to precool and reduce AC service during event hours, but were unable to because their air-conditioning units were undersized. On a 100 F reference day, load impacts of all participants during events averaged 14%, while load impacts of office and retail buildings (excluding restaurants) reached 20%. Overall, pilot participants including restaurants had 2007-2008 summer energy savings of 20% and bill savings of 30%. About 80% of participants said that the program met or surpassed their expectations, and three-quarters said they would probably or definitely participate again without the $120 participation incentive. These results provide evidence that energy efficiency programs, dynamic rates and load control programs can be used concurrently and effectively in the small business sector, and that communicating thermostats are a reliable tool for providing air-conditioning load shed and enhancing the ability

  1. Muscle metaboreflex control of the circulation during exercise

    DEFF Research Database (Denmark)

    Boushel, Robert Christopher

    2010-01-01

    . It can both elevate and decrease muscle blood flow depending on (1) the intensity and mode of contraction, (2) the limb in which the reflex is evoked, (3) the strength of the signal defined by the muscle mass, (4) the extent to which blood flow is redistributed from inactive vascular beds to increase......This review covers the control of blood pressure, cardiac output and muscle blood flow by the muscle metaboreflex which involves chemically sensitive nerves located in muscle parenchyma activated by metabolites accumulating in the muscle during contraction. The efferent response to metaboreflex...... activation is an increase in sympathetic nerve activity that constricts the systemic vasculature and also evokes parallel inotropic and chronotropic effects on the heart to increase cardiac output. The metaboreflex elicits a significant blood pressure elevating response during exercise and functions...

  2. System of liquid thermostatic control for jet experiments on NMR

    International Nuclear Information System (INIS)

    Selivanov, S.I.; Bogatkin, R.A.; Ershov, B.A.

    1983-01-01

    The system of liquid thermostating of a sensor of NMR spectrometer, used as a registering device in the method of continuous and interrupting stream, is described. Such method of thermostating permits to make kinetic measurements in the temperature range from -40 to +60 deg C with the accuracy +-0.1 deg C and removes the necessity for applying secondary temperature NMR standards

  3. Deterministic thermostats, theories of nonequilibrium systems and parallels with the ergodic condition

    International Nuclear Information System (INIS)

    Jepps, Owen G; Rondoni, Lamberto

    2010-01-01

    Deterministic 'thermostats' are mathematical tools used to model nonequilibrium steady states of fluids. The resulting dynamical systems correctly represent the transport properties of these fluids and are easily simulated on modern computers. More recently, the connection between such thermostats and entropy production has been exploited in the development of nonequilibrium fluid theories. The purpose and limitations of deterministic thermostats are discussed in the context of irreversible thermodynamics and the development of theories of nonequilibrium phenomena. We draw parallels between the development of such nonequilibrium theories and the development of notions of ergodicity in equilibrium theories. (topical review)

  4. Determination of the mechanical thermostat electrical contacts switching quality with sound and vibration analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rejc, Jure; Munih, Marko [University of Ljubljana, Ljubljana (Slovenia)

    2017-05-15

    A mechanical thermostat is a device that switches heating or cooling appliances on or off based on temperature. For this kind of use, electronic or mechanical switching concepts are applied. During the production of electrical contacts, several irregularities can occur leading to improper switching events of the thermostat electrical contacts. This paper presents a non-obstructive method based on the fact that when the switching event occurs it can be heard and felt by human senses. We performed several laboratory tests with two different methods. The first method includes thermostat switch sound signal analysis during the switching event. The second method is based on sampling of the accelerometer signal during the switching event. The results show that the sound analysis approach has great potential. The approach enables an accurate determination of the switching event even if the sampled signal carries also the switching event of the neighbour thermostat.

  5. Bioimpedance harmonic analysis as a tool to simultaneously assess circulation and nervous control.

    Science.gov (United States)

    Mudraya, I S; Revenko, S V; Nesterov, A V; Gavrilov, I Yu; Kirpatovsky, V I

    2011-07-01

    Multicycle harmonic (Fourier) analysis of bioimpedance was employed to simultaneously assess circulation and neural activity in visceral (rat urinary bladder) and somatic (human finger) organs. The informative value of the first cardiac harmonic of the bladder impedance as an index of bladder circulation is demonstrated. The individual reactions of normal and obstructive bladders in response to infusion cystometry were recorded. The potency of multicycle harmonic analysis of bioimpedance to assess sympathetic and parasympathetic neural control in urinary bladder is discussed. In the human finger, bioimpedance harmonic analysis revealed three periodic components at the rate of the heart beat, respiration and Mayer wave (0.1 Hz), which were observed under normal conditions and during blood flow arrest in the hand. The revealed spectrum peaks were explained by the changes in systemic blood pressure and in regional vascular tone resulting from neural vasomotor control. During normal respiration and circulation, two side cardiac peaks were revealed in a bioimpedance amplitude spectrum, whose amplitude reflected the depth of amplitude respiratory modulation of the cardiac output. During normal breathing, the peaks corresponding to the second and third cardiac harmonics were split, reflecting frequency respiratory modulation of the heart rate. Multicycle harmonic analysis of bioimpedance is a novel potent tool to examine the interaction between the respiratory and cardiovascular system and to simultaneously assess regional circulation and neural influences in visceral and somatic organs.

  6. Proceedings of the 2004 NASA/ONR Circulation Control Workshop, Part 2

    Science.gov (United States)

    Jones, Gregory S. (Editor); Joslin, Ronald D. (Editor)

    2005-01-01

    This conference proceeding is comprised of papers that were presented at the NASA/ONR Circulation Control Workshop held 16-17 March 2004 at the Radisson-Hampton in Hampton, VA. Over two full days, 30 papers and 4 posters were presented with 110 scientists and engineers in attendance, representing 3 countries. As technological advances influence the efficiency and effectiveness of aerodynamic and hydrodynamic applications, designs, and operations, this workshop was intended to address the technologies, systems, challenges and successes specific to Coanda driven circulation control in aerodynamics and hydrodynamics. A major goal of this workshop was to determine the state-of-the-art in circulation control and to assess the future directions and applications for circulation control. The 2004 workshop addressed applications, experiments, computations, and theories related to circulation control, emphasizing fundamental physics, systems analysis, and applied research. The workshop consisted of single session oral presentations, posters, and written papers that are documented in this unclassified conference proceeding. The format of this written proceeding follows the agenda of the workshop. Each paper is followed with the presentation given at the workshop. the editors compiled brief summaries for each effort that is at the end of this proceeding. These summaries include the paper, oral presentation, and questions or comments that occurred during the workshop. The 2004 Circulation Control Workshop focused on applications including Naval vehicles (Surface and Underwater vehicles), Fixed Wing Aviation (general aviation, commercial, cargo, and business aircraft); V/STOL platforms (helicopters, military aircraft, tilt rotors); propulsion systems (propellers, jet engines, gas turbines), and ground vehicles (automotive, trucks, and other); wind turbines, and other nontraditional applications (e.g., vacuum cleaner, ceiling fan). As part of the CFD focus area of the 2004 CC

  7. Building America Case Study: The Impact of Thermostat Placement in Low-Load Homes in Sunny Climates, Denver, Colorado

    Energy Technology Data Exchange (ETDEWEB)

    2016-02-01

    Modern, energy-efficient homes conforming to the Zero Energy Ready Home standard face the challenge of meeting high customer expectations for comfort. Traditional heating, ventilation, and air conditioning (HVAC) sizing and control strategies may be insufficient to adequately condition each zone due to unique load patterns in each room caused by a number of factors. These factors include solar heat gains, occupant-related gains, and gains associated with appliances and electronics. Because of shrinking shell loads, these intermittent factors are having an increasingly significant impact on the thermal load in each zone. Consequently, occupant comfort can be compromised. To evaluate the impact of climate and house geometry, as well as HVAC system and control strategies on comfort conditions, IBACOS analyzed the results of 99 TRNSYS multiple-zone simulations. The results of this analysis indicate that for simple-geometry and single-story plans, a single zone and thermostat can adequately condition the entire house. Demanding house geometry and houses with multiple stories require the consideration of multiple thermostats and multiple zones.

  8. Experimental and Numerical Studies of Controlling Thermal Cracks in Mass Concrete Foundation by Circulating Water

    Directory of Open Access Journals (Sweden)

    Wenchao Liu

    2016-04-01

    Full Text Available This paper summarizes an engineering experience of solving the problem of thermal cracking in mass concrete by using a large project, Zhongguancun No.1 (Beijing, China, as an example. A new method is presented for controlling temperature cracks in the mass concrete of a foundation. The method involves controlled cycles of water circulating between the surface of mass concrete foundation and the atmospheric environment. The temperature gradient between the surface and the core of the mass concrete is controlled at a relatively stable state. Water collected from the well-points used for dewatering and from rainfall is used as the source for circulating water. Mass concrete of a foundation slab is experimentally investigated through field temperature monitoring. Numerical analyses are performed by developing a finite element model of the foundation with and without water circulation. The calculation parameters are proposed based on the experiment, and finite element analysis software MIDAS/CIVIL is used to calculate the 3D temperature field of the mass concrete during the entire process of heat of hydration. The numerical results are in good agreement with the measured results. The proposed method provides an alternative practical basis for preventing thermal cracks in mass concrete.

  9. On the effect of leading edge blowing on circulation control airfoil aerodynamics

    Science.gov (United States)

    Mclachlan, B. G.

    1987-01-01

    In the present context the term circulation control is used to denote a method of lift generation that utilizes tangential jet blowing over the upper surface of a rounded trailing edge airfoil to determine the location of the boundary layer separation points, thus setting an effective Kutta condition. At present little information exists on the flow structure generated by circulation control airfoils under leading edge blowing. Consequently, no theoretical methods exist to predict airfoil performance under such conditions. An experimental study of the flow field generated by a two dimensional circulation control airfoil under steady leading and trailing edge blowing was undertaken. The objective was to fundamentally understand the overall flow structure generated and its relation to airfoil performance. Flow visualization was performed to define the overall flow field structure. Measurements of the airfoil forces were also made to provide a correlation of the observed flow field structure to airfoil performance. Preliminary results are presented, specifically on the effect on the flow field structure of leading edge blowing, alone and in conjunction with trailing edge blowing.

  10. Development of a cerebral circulation model for the automatic control of brain physiology.

    Science.gov (United States)

    Utsuki, T

    2015-01-01

    In various clinical guidelines of brain injury, intracranial pressure (ICP), cerebral blood flow (CBF) and brain temperature (BT) are essential targets for precise management for brain resuscitation. In addition, the integrated automatic control of BT, ICP, and CBF is required for improving therapeutic effects and reducing medical costs and staff burden. Thus, a new model of cerebral circulation was developed in this study for integrative automatic control. With this model, the CBF and cerebral perfusion pressure of a normal adult male were regionally calculated according to cerebrovascular structure, blood viscosity, blood distribution, CBF autoregulation, and ICP. The analysis results were consistent with physiological knowledge already obtained with conventional studies. Therefore, the developed model is potentially available for the integrative control of the physiological state of the brain as a reference model of an automatic control system, or as a controlled object in various control simulations.

  11. ESTABLISHMENT OF AN ENVIRONMENTAL CONTROL TECHNOLOGY LABORATORY WITH A CIRCULATING FLUIDIZED-BED COMBUSTION SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Wei-Ping Pan; Andy Wu; John T. Riley

    2004-10-30

    This report is to present the progress made on the project ''Establishment of an Environmental Control Technology Laboratory (ECTL) with a Circulating Fluidized-Bed Combustion (CFBC) System'' during the period July 1, 2004 through September 30, 2004. The following tasks have been completed. First, renovation of the new Combustion Laboratory and the construction of the Circulating Fluidized-Bed (CFB) Combustor Building have started. Second, the design if the component parts of the CFBC system have been reviewed and finalized so that the drawings may be released to the manufacturers during the next quarter. Third, the experiments for solid waste (chicken litter) incineration have been conducted using a Thermogravimetric Analyzer (TGA). This is in preparation for testing in the simulated fluidized-bed combustor. The experimental results from this study are presented in this report. Finally, the proposed work for the next quarter has been outlined in this report.

  12. Temperature control characteristics analysis of lead-cooled fast reactor with natural circulation

    International Nuclear Information System (INIS)

    Yang, Minghan; Song, Yong; Wang, Jianye; Xu, Peng; Zhang, Guangyu

    2016-01-01

    Highlights: • The LFR temperature control system are analyzed with frequency domain method. • The temperature control compensator is designed according to the frequency analysis. • Dynamic simulation is performed by SIMULINK and RELAP5-HD. - Abstract: Lead-cooled Fast Reactor (LFR) with natural circulation in primary system is among the highlights in advance nuclear reactor research, due to its great superiority in reactor safety and reliability. In this work, a transfer function matrix describing coolant temperature dynamic process, obtained by Laplace transform of the one-dimensional system dynamic model is developed in order to investigate the temperature control characteristics of LFR. Based on the transfer function matrix, a close-loop coolant temperature control system without compensator is built. The frequency domain analysis indicates that the stability and steady-state of the temperature control system needs to be improved. Accordingly, a temperature compensator based on Proportion–Integration and feed-forward is designed. The dynamic simulation of the whole system with the temperature compensator for core power step change is performed with SIMULINK and RELAP5-HD. The result shows that the temperature compensator can provide superior coolant temperature control capabilities in LFR with natural circulation due to the efficiency of the frequency domain analysis method.

  13. Asymmetric Distributions of Energetic Circulating Ions and Sawtooth Control using ICCD and Unbalanced NBI

    International Nuclear Information System (INIS)

    Graves, J. P.

    2007-01-01

    There is little doubt that various auxiliary heating systems are successfully and routinely controlling sawteeth. There is however some room for improving our understanding of the mechanisms that influence these important changes to the discharges. A mechanism that appears to be common across ECCS, ICCD and unbalanced NBI discharges involves the effect of the q = 1 localised current drive perturbation on resistive diffusion during the sawtooth ramp. Nevertheless, it is important to look for explanations for sawtooth control which may exist in ion based auxiliary systems, but may differ or not exist in electron auxiliary means of sawtooth control. The reason for this is that monster sawteeth, initially lengthened by trapped energetic ions, have up to the present day only been controlled using ICCD, while in ITER the primary method for sawtooth control could be ECCD. A mechanism based on the finite orbit width of parallel asymmetric energetic circulating particles is only non-negligible for ion based auxiliary systems. The present contribution examines the relevance of the latter in sawtooth control experiments, such as those using ICCD and NBI at JET, by looking carefully at the role of circulating ions close to the trapped boundary. At such pitch angles the orbit width is largest, and the parallel asymmetry of the distribution function has the greatest influence. (Author)

  14. Variations of the Atlantic meridional overturning circulation in control and transient simulations of the last millennium

    Directory of Open Access Journals (Sweden)

    D. Hofer

    2011-02-01

    Full Text Available The variability of the Atlantic meridional overturing circulation (AMOC strength is investigated in control experiments and in transient simulations of up to the last millennium using the low-resolution Community Climate System Model version 3. In the transient simulations the AMOC exhibits enhanced low-frequency variability that is mainly caused by infrequent transitions between two semi-stable circulation states which amount to a 10 percent change of the maximum overturning. One transition is also found in a control experiment, but the time-varying external forcing significantly increases the probability of the occurrence of such events though not having a direct, linear impact on the AMOC. The transition from a high to a low AMOC state starts with a reduction of the convection in the Labrador and Irminger Seas and goes along with a changed barotropic circulation of both gyres in the North Atlantic and a gradual strengthening of the convection in the Greenland-Iceland-Norwegian (GIN Seas. In contrast, the transition from a weak to a strong overturning is induced by decreased mixing in the GIN Seas. As a consequence of the transition, regional sea surface temperature (SST anomalies are found in the midlatitude North Atlantic and in the convection regions with an amplitude of up to 3 K. The atmospheric response to the SST forcing associated with the transition indicates a significant impact on the Scandinavian surface air temperature (SAT in the order of 1 K. Thus, the changes of the ocean circulation make a major contribution to the Scandinavian SAT variability in the last millennium.

  15. Numerical study comparing RANS and LES approaches on a circulation control airfoil

    International Nuclear Information System (INIS)

    Rumsey, Christopher L.; Nishino, Takafumi

    2011-01-01

    Highlights: → RANS compared with LES for circulation control airfoil. → RANS turbulence models need to account for streamline curvature. → RANS models yield higher lift than LES in spite of predicting similar jet separation. - Abstract: A numerical study over a nominally two-dimensional circulation control airfoil is performed using a large-eddy simulation code and two Reynolds-averaged Navier-Stokes codes. Different Coanda jet blowing conditions are investigated. In addition to investigating the influence of grid density, a comparison is made between incompressible and compressible flow solvers. The incompressible equations are found to yield negligible differences from the compressible equations up to at least a jet exit Mach number of 0.64. The effects of different turbulence models are also studied. Models that do not account for streamline curvature effects tend to predict jet separation from the Coanda surface too late, and can produce non-physical solutions at high blowing rates. Three different turbulence models that account for streamline curvature are compared with each other and with large eddy simulation solutions. All three models are found to predict the Coanda jet separation location reasonably well, but one of the models predicts specific flow field details near the Coanda surface prior to separation much better than the other two. All Reynolds-averaged Navier-Stokes computations produce higher circulation than large eddy simulation computations, with different stagnation point location and greater flow acceleration around the nose onto the upper surface. The precise reasons for the higher circulation are not clear, although it is not solely a function of predicting the jet separation location correctly.

  16. Numerical study comparing RANS and LES approaches on a circulation control airfoil

    Energy Technology Data Exchange (ETDEWEB)

    Rumsey, Christopher L., E-mail: c.l.rumsey@nasa.gov [Computational AeroSciences Branch, NASA Langley Research Center, Hampton, VA 23681-2199 (United States); Nishino, Takafumi [Advanced Supercomputing Division, NASA Ames Research Center, Moffett Field, CA 94035-1000 (United States)

    2011-10-15

    Highlights: > RANS compared with LES for circulation control airfoil. > RANS turbulence models need to account for streamline curvature. > RANS models yield higher lift than LES in spite of predicting similar jet separation. - Abstract: A numerical study over a nominally two-dimensional circulation control airfoil is performed using a large-eddy simulation code and two Reynolds-averaged Navier-Stokes codes. Different Coanda jet blowing conditions are investigated. In addition to investigating the influence of grid density, a comparison is made between incompressible and compressible flow solvers. The incompressible equations are found to yield negligible differences from the compressible equations up to at least a jet exit Mach number of 0.64. The effects of different turbulence models are also studied. Models that do not account for streamline curvature effects tend to predict jet separation from the Coanda surface too late, and can produce non-physical solutions at high blowing rates. Three different turbulence models that account for streamline curvature are compared with each other and with large eddy simulation solutions. All three models are found to predict the Coanda jet separation location reasonably well, but one of the models predicts specific flow field details near the Coanda surface prior to separation much better than the other two. All Reynolds-averaged Navier-Stokes computations produce higher circulation than large eddy simulation computations, with different stagnation point location and greater flow acceleration around the nose onto the upper surface. The precise reasons for the higher circulation are not clear, although it is not solely a function of predicting the jet separation location correctly.

  17. Constraints of using thermostatic expansion valves to operate air-cooled chillers at lower condensing temperatures

    International Nuclear Information System (INIS)

    Yu, F.W.; Chan, K.T.; Chu, H.Y.

    2006-01-01

    Thermostatic expansion valves (TXVs) have long been used in air-cooled chillers to implement head pressure control under which the condensing temperature is kept high at around 50 o C by staging condenser fans as few as possible. This paper considers how TXVs prevent the chillers from operating with an increased COP at lower condensing temperatures when the chiller load or outdoor temperature drops. An analysis on an existing air-cooled reciprocating chiller showed that the range of differential pressures across TXVs restricts the maximum heat rejection airflow required to increase the chiller COP, though the set point of condensing temperature is reduced to 22 o C from a high level of 45 o C. It is possible to use electronic expansion valves to meet the differential pressure requirements for maximum chiller COP. There is a maximum of 28.7% increase in the chiller COP when the heat rejection airflow is able to be maximized in various operating conditions. The results of this paper emphasize criteria for lowering the condensing temperature to enhance the performance of air-cooled chillers

  18. Steam drum level control studies of a natural circulation multi loop reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Rajesh; Contractor, A.D.; Srivastava, Abhishek; Lele, H.G. [Bhabha Atomic Research Centre, Trombay, Mumbai (India). Reactor Safety Div.; Vaze, K.K. [Bhabha Atomic Research Centre, Trombay, Mumbai (India). Reactor Design and Development Group

    2013-12-15

    The proposed heavy water moderated and light water cooled pressure tube type boiling water reactor works on natural circulation at all power levels. It has parallel inter-connected loops with 452 boiling channels in the main heat transport system configuration. These multiple (four) interconnected loops influence the steam drum level control adversely through the common reactor inlet header. Alternate design studies made earlier for efficient control of SD levels have shown favorable results. This has lead to explore further the present scheme with the compartmentalization of CRIH into four compartments catering to four loops separately. The conventional 3-element level control has been found to be working satisfactorily. The interconnections between ECCS header and inlet header compartments have also increased the safety margin for various LOCA and design basis events. The paper deals with the SD level control aspects for this novel MHT configuration which has been analyzed for various PIEs (Postulated Initiating Events) and found to be satisfactory. (orig.)

  19. Investigation of some copolymers based on acrylic salts as circulation loss control agents

    Directory of Open Access Journals (Sweden)

    Ahmed Mohamed Alsabagh

    2013-12-01

    The prepared copolymers were investigated as loss circulation control materials by measuring different filtration parameters such as; spurt loss, fluid loss and permeability plugging tester value according to the American Petroleum Institute (API standard. From the obtained data, it was found that the 0.6% from the poly[PA-co-AM](0.4:0.6 exhibited the best results of the filtration parameters among the other copolymers. At the same time all the studied copolymers enhanced the rheological properties of the drilling mud. These results were discussed on the light of the swelling capacity of the copolymers.

  20. An Open Source Low-Cost Wireless Control System for a Forced Circulation Solar Plant.

    Science.gov (United States)

    Salamone, Francesco; Belussi, Lorenzo; Danza, Ludovico; Ghellere, Matteo; Meroni, Italo

    2015-11-05

    The article describes the design phase, development and practical application of a low-cost control system for a forced circulation solar plant in an outdoor test cell located near Milan. Such a system provides for the use of an electric pump for the circulation of heat transfer fluid connecting the solar thermal panel to the storage tank. The running plant temperatures are the fundamental parameter to evaluate the system performance such as proper operation, and the control and management system has to consider these parameters. A solar energy-powered wireless-based smart object was developed, able to monitor the running temperatures of a solar thermal system and aimed at moving beyond standard monitoring approaches to achieve a low-cost and customizable device, even in terms of installation in different environmental conditions. To this end, two types of communications were used: the first is a low-cost communication based on the ZigBee protocol used for control purposes, so that it can be customized according to specific needs, while the second is based on a Bluetooth protocol used for data display.

  1. An Open Source Low-Cost Wireless Control System for a Forced Circulation Solar Plant

    Directory of Open Access Journals (Sweden)

    Francesco Salamone

    2015-11-01

    Full Text Available The article describes the design phase, development and practical application of a low-cost control system for a forced circulation solar plant in an outdoor test cell located near Milan. Such a system provides for the use of an electric pump for the circulation of heat transfer fluid connecting the solar thermal panel to the storage tank. The running plant temperatures are the fundamental parameter to evaluate the system performance such as proper operation, and the control and management system has to consider these parameters. A solar energy-powered wireless-based smart object was developed, able to monitor the running temperatures of a solar thermal system and aimed at moving beyond standard monitoring approaches to achieve a low-cost and customizable device, even in terms of installation in different environmental conditions. To this end, two types of communications were used: the first is a low-cost communication based on the ZigBee protocol used for control purposes, so that it can be customized according to specific needs, while the second is based on a Bluetooth protocol used for data display.

  2. NASA High-Reynolds Number Circulation Control Research - Overview of CFD and Planned Experiments

    Science.gov (United States)

    Milholen, W. E., II; Jones, Greg S.; Cagle, Christopher M.

    2010-01-01

    A new capability to test active flow control concepts and propulsion simulations at high Reynolds numbers in the National Transonic Facility at the NASA Langley Research Center is being developed. This technique is focused on the use of semi-span models due to their increased model size and relative ease of routing high-pressure air to the model. A new dual flow-path high-pressure air delivery station has been designed, along with a new high performance transonic sem -si pan wing model. The modular wind tunnel model is designed for testing circulation control concepts at both transonic cruise and low-speed high-lift conditions. The ability of the model to test other active flow control techniques will be highlighted. In addition, a new higher capacity semi-span force and moment wind tunnel balance has been completed and calibrated to enable testing at transonic conditions.

  3. End users heat energy savings using thermostat regulation valves radiators, v. 16(64)

    International Nuclear Information System (INIS)

    Jakimovska, Emilija Misheva; Potsev, Eftim

    2008-01-01

    Billing the used heat energy offers the opportunity to motivate end users to use the heat energy rationally and to save the energy. Installing the thermostat valves on the radiators it is possible frequently to regulate the room temperature and to use the heat gains, obtaining comfortable climate in the apartments and saving the energy. Thermostat valves give the possibility to use the heat energy rationally and save the energy, and these way and users can regulate the heat energy consumption according to their own level of thermal comfort. (Author)

  4. End users heat energy savings using thermostat regulation valves radiators, v. 16(63)

    International Nuclear Information System (INIS)

    Jakimovska, Emilija Misheva; Potsev, Eftim

    2008-01-01

    Billing the used heat energy offers the opportunity to motivate end users to use the heat energy rationally and to save the energy. Installing the thermostat valves on the radiators it is possible frequently to regulate the room temperature and to use the heat gains, obtaining comfortable climate in the apartments and saving the energy. Thermostat valves give the possibility to use the heat energy rationally and save the energy, and these way and users can regulate the heat energy consumption according to their own level of thermal comfort. (Author)

  5. Circulating folate levels and colorectal adenoma: a case-control study and a meta-analysis.

    Science.gov (United States)

    Park, Yeong Mi; Youn, Jiyoung; Cho, Chang Ho; Kim, Sung Hi; Lee, Jung Eun

    2017-10-01

    The relationship between folate and colorectal neoplasia remains controversial. We examined the association between serum folate concentrations and colorectal adenomas in a case-control study of Korean adults and conducted a meta-analysis. Our case-control study included 113 pairs of case and control who underwent colonoscopy and provided blood samples. We used multivariable conditional logistic regression models to obtain the odds ratios and 95% confidence interval (CIs). For meta-analysis, we identified the relevant studies by searching the PubMed database up to February 2017, included our case-control study and combined the study-specific relative risks (RRs) using a random-effects model. In this case-control study, we included 58 men and 55 women with colorectal adenomas and sex and fasting status matched the controls. We did not find any significant association between the serum folate levels and colorectal adenomas in either men or women. For meta-analysis, a total of eleven studies were included in our analysis and classified into two groups; polyp clearance group (PC) for the studies that included participants who underwent endoscopies and had their polyps removed at baseline; and no polyp clearance group (NPC) for the studies that included participants whose histories of endoscopies were unknown or who underwent their first endoscopies. Four PC (1,311 cases and 1,672 non-cases) and eight NPC studies (3,501 cases and 11,347 non-cases) were included. The combined RRs (95% CIs) comparing the bottom with the top categories of circulating folate levels were 1.07 (0.97-1.18) for the NPC group but 1.45 (1.16-1.74) for the PC group. Low circulating folate levels were associated with new adenoma formation.

  6. Reynolds-Averaged Navier-Stokes Simulation of a 2D Circulation Control Wind Tunnel Experiment

    Science.gov (United States)

    Allan, Brian G.; Jones, Greg; Lin, John C.

    2011-01-01

    Numerical simulations are performed using a Reynolds-averaged Navier-Stokes (RANS) flow solver for a circulation control airfoil. 2D and 3D simulation results are compared to a circulation control wind tunnel test conducted at the NASA Langley Basic Aerodynamics Research Tunnel (BART). The RANS simulations are compared to a low blowing case with a jet momentum coefficient, C(sub u), of 0:047 and a higher blowing case of 0.115. Three dimensional simulations of the model and tunnel walls show wall effects on the lift and airfoil surface pressures. These wall effects include a 4% decrease of the midspan sectional lift for the C(sub u) 0.115 blowing condition. Simulations comparing the performance of the Spalart Allmaras (SA) and Shear Stress Transport (SST) turbulence models are also made, showing the SST model compares best to the experimental data. A Rotational/Curvature Correction (RCC) to the turbulence model is also evaluated demonstrating an improvement in the CFD predictions.

  7. Phagocytosis, bacterial killing, and cytokine activation of circulating blood neutrophils in horses with severe equine asthma and control horses.

    Science.gov (United States)

    Vanderstock, Johanne M; Lecours, Marie-Pier; Lavoie-Lamoureux, Annouck; Gottschalk, Marcelo; Segura, Mariela; Lavoie, Jean-Pierre; Jean, Daniel

    2018-04-01

    OBJECTIVE To evaluate in vitro phagocytosis and bactericidal activity of circulating blood neutrophils in horses with severe equine asthma and control horses and to determine whether circulating blood neutrophils in horses with severe equine asthma have an increase in expression of the proinflammatory cytokine tumor necrosis factor (TNF)-α and the chemokine interleukin (IL)-8 and a decrease in expression of the anti-inflammatory cytokine IL-10 in response to bacteria. ANIMALS 6 horses with severe equine asthma and 6 control horses. PROCEDURES Circulating blood neutrophils were isolated from horses with severe equine asthma and control horses. Phagocytosis was evaluated by use of flow cytometry. Bactericidal activity of circulating blood neutrophils was assessed by use of Streptococcus equi and Streptococcus zooepidemicus as targets, whereas the cytokine mRNA response was assessed by use of a quantitative PCR assay. RESULTS Circulating blood neutrophils from horses with severe equine asthma had significantly lower bactericidal activity toward S zooepidemicus but not toward S equi, compared with results for control horses. Phagocytosis and mRNA expression of TNF-α, IL-8, and IL-10 were not different between groups. CONCLUSIONS AND CLINCAL RELEVANCE Impairment of bactericidal activity of circulating blood neutrophils in horses with severe equine asthma could contribute to an increased susceptibility to infections.

  8. Investigation on energy storage and quick load change control of subcritical circulating fluidized bed boiler units

    International Nuclear Information System (INIS)

    Gao, Mingming; Hong, Feng; Liu, Jizhen

    2017-01-01

    Highlights: • The model of energy storage of subcritical CFB boilers is established. • The capacity and increment rate of heat storage are quantified. • A novel load control strategy is proposed to improve the quick load change ability. • An application on the 300 MW CFB unit proves the load change rate to 5–8 MW/min. - Abstract: The energy storage of circulating fluidized bed (CFB) boilers on fuel side cannot be ignored due to the special combustion type different from pulverized coal boilers. The sizable energy storage makes it possible for CFB units to enhance the quick load change ability and to increase the scale of new energy power connected into grid. Through mechanism analysis, the model of energy storage of subcritical CFB boilers has been established for the first time. Then by the project practice, the quantitative analysis is demonstrated for the capacity and control characteristics of energy storage on fuel side and steam water side. Based on the control characteristics and the transformation of the energy storage, a coordinated control system (CCS) control strategy named advanced energy balance (AEB) is designed to shorten the response time through the use of energy storage and to accelerate the load change speed of subcritical CFB units. Finally, a case study on a 300 MW CFB unit proves the feasibility of the proposed control strategy.

  9. ESTABLISHMENT OF AN ENVIRONMENTAL CONTROL TECHNOLOGY LABORATORY WITH A CIRCULATING FLUIDIZED-BED COMBUSTION SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Wei-Ping Pan; Andy Wu; John T. Riley

    2005-04-30

    This report is to present the progress made on the project ''Establishment of an Environmental Control Technology Laboratory (ECTL) with a Circulating Fluidized-Bed Combustion (CFBC) System'' during the period January 1, 2005 through March 31, 2005. The following tasks have been completed. First, the renovation of the new Combustion Laboratory is nearly complete, and the construction of the Circulating Fluidized-Bed (CFB) Combustor Building is in the final stages. Second, the fabrication and manufacture of the CFBC Facility is being discussed with a potential contractor. Discussions with potential contactor regarding the availability of materials and current machining capabilities have resulted in the modification of the original designs. The selection of the fabrication contractor for the CFBC Facility is expected during the next quarter. Third, co-firing experiments conducted with coal and chicken waste have been initiated in the laboratory-scale simulated fluidized-bed facility. The experimental results from this study are presented in this report. Finally, the proposed work for the next quarter is described in this report.

  10. 'Downward control' of the mean meridional circulation and temperature distribution of the polar winter stratosphere

    Science.gov (United States)

    Garcia, Rolando R.; Boville, Byron A.

    1994-01-01

    According to the 'downward control' principle, the extratropical mean vertical velocity on a given pressure level is approximately proportional to the meridional gradient of the vertically integrated zonal force per unit mass exerted by waves above that level. In this paper, a simple numerical model that includes parameterizations of both planetary and gravity wave breaking is used to explore the influence of gravity wave breaking in the mesosphere on the mean meridional circulation and temperature distribution at lower levels in the polar winter stratosphere. The results of these calculations suggest that gravity wave drag in the mesosphere can affect the state of the polar winter stratosphere down to altitudes below 30 km. The effect is most important when planetary wave driving is relatively weak: that is, during southern winter and in early northern winter. In southern winter, downwelling weakens by a factor of 2 near the stratospause and by 20% at 30 km when gravity wave drag is not included in the calculations. As a consequence, temperatures decrease considerably throughout the polar winter stratosphere (over 20 K above 40 km and as much as 8 K at 30 km, where the effect is enhanced by the long radiative relaxation timescale). The polar winter states obtained when gravity wave drag is omitted in this simple model resemble the results of simulations with some general circulation models and suggest that some of the shortcomings of the latter may be due to a deficit in mesospheric momentum deposition by small-scale gravity waves.

  11. The presence and growth of Legionella species in thermostatic shower mixer taps: an exploratory field study

    NARCIS (Netherlands)

    Joost van Hoof; P.W.J.J. van der Wielen; E. van der Blom; O.W.W. Nuijten; L. Hornstra

    2014-01-01

    Legislation in the Netherlands requires routine analysis of drinking water samples for cultivable Legionella species from high-priority installations. A field study was conducted to investigate the presence of Legionella species in thermostatic shower mixer taps. Water samples and the interior of

  12. Investigation of charges for thermostatic expansion valves containing condensable and non condensable gas

    DEFF Research Database (Denmark)

    Langmaack, Lasse Nicolai; Knudsen, Hans-Jørgen Høgaard

    2006-01-01

    The bulb of a thermostatic expansion valve (TXV) is basically a temperature-pressure converter. It senses the temperature at the outlet of the evaporator, and the substance in the bulb (charge) generates the corresponding saturation pressure inside the bulb. The aim of the work presented in this ...

  13. Design and Development of Autonomous High Voltage Driving System for DEAP Actuator in Radiator Thermostat

    DEFF Research Database (Denmark)

    Huang, Lina; Zhang, Zhe; Andersen, Michael A. E.

    2014-01-01

    In radiator thermostat applications, DEAP (Dielectric Electro Active Polymer) actuator tends to be a good candidate to replace the conventional self-actuating or step motor based actuator due to its intrinsic advantages. The capacitive property and high voltage (HV) driving demand of DEAP actuator...

  14. Current situation, genetic relationship and control measures of infectious bronchitis virus variants circulating in African regions

    Directory of Open Access Journals (Sweden)

    Khadija Khataby

    2016-08-01

    Three S1 gene hypervariable regions were studied and compared to the reference genotypes/serotypes that found emerging in African regions. This comparison was based on phylogenetic trees, nucleotide and amino-acid sequence analysis. It clearly appears that IBV variants reported in Africa, display a low genetic relationship between them and with the majority of the reference strains emerging in neighboring countries, except the case of variants from Libya and Egypt that show a high relatedness. Also the Massachusetts serotypes were the most prevalent co-circulating with both serotypes, Italy02 type in Morocco and Qx-like genotype in South part of the African continent. In order to control the IBV variants in African regions, an efficient vaccination strategy program should be implemented.

  15. Relationship of Circulating Hyaluronic Acid Levels to Disease Control in Asthma and Asthmatic Pregnancy

    Science.gov (United States)

    Eszes, Noémi; Toldi, Gergely; Bohács, Anikó; Ivancsó, István; Müller, Veronika; Rigó Jr., János; Losonczy, György; Vásárhelyi, Barna; Tamási, Lilla

    2014-01-01

    Uncontrolled asthma is a risk factor for pregnancy-related complications. Hyaluronic acid (HA), a potential peripheral blood marker of tissue fibrosis in various diseases, promotes eosinophil survival and plays a role in asthmatic airway inflammation as well as in physiological processes necessary to maintain normal pregnancy; however the level of circulating HA in asthma and asthmatic pregnancy is unknown. We investigated HA levels in asthmatic patients (N = 52; asthmatic pregnant (AP) N = 16; asthmatic non-pregnant (ANP) N = 36) and tested their relationship to asthma control. Serum HA level was lower in AP than in ANP patients (27 [24.7–31.55] vs. 37.4 [30.1–66.55] ng/mL, p = 0.006); the difference attenuated to a trend after its adjustment for patients’ age (p = 0.056). HA levels and airway resistance were positively (r = 0.467, p = 0.004), HA levels and Asthma Control Test (ACT) total score inversely (r = −0.437, p = 0.01) associated in ANP patients; these relationships remained significant even after their adjustments for age. The potential value of HA in the determination of asthma control was analyzed using ROC analysis which revealed that HA values discriminate patients with ACT total score ≥20 (controlled patients) and <20 (uncontrolled patients) with a 0.826 efficacy (AUC, 95% CI: 0.69–0.97, p = 0.001) when 37.4 ng/mL is used as cut-off value in ANP group, and with 0.78 efficacy (AUC, 95% CI: 0.65–0.92, p = 0.0009) in the whole asthmatic cohort. In conclusion circulating HA might be a marker of asthma control, as it correlates with airway resistance and has good sensitivity in the detection of impaired asthma control. Decrease of HA level in pregnancy may be the consequence of pregnancy induced immune tolerance. PMID:24736408

  16. Robust design method and thermostatic experiment for multiple piezoelectric vibration absorber system

    International Nuclear Information System (INIS)

    Nambu, Yohsuke; Takashima, Toshihide; Inagaki, Akiya

    2015-01-01

    This paper examines the effects of connecting multiplexing shunt circuits composed of inductors and resistors to piezoelectric transducers so as to improve the robustness of a piezoelectric vibration absorber (PVA). PVAs are well known to be effective at suppressing the vibration of an adaptive structure; their weakness is low robustness to changes in the dynamic parameters of the system, including the main structure and the absorber. In the application to space structures, the temperature-dependency of capacitance of piezoelectric ceramics is the factor that causes performance reduction. To improve robustness to the temperature-dependency of the capacitance, this paper proposes a multiple-PVA system that is composed of distributed piezoelectric transducers and several shunt circuits. The optimization problems that determine both the frequencies and the damping ratios of the PVAs are multi-objective problems, which are solved using a real-coded genetic algorithm in this paper. A clamped aluminum beam with four groups of piezoelectric ceramics attached was considered in simulations and experiments. Numerical simulations revealed that the PVA systems designed using the proposed method had tolerance to changes in the capacitances. Furthermore, experiments using a thermostatic bath were conducted to reveal the effectiveness and robustness of the PVA systems. The maximum peaks of the transfer functions of the beam with the open circuit, the single-PVA system, the double-PVA system, and the quadruple-PVA system at 20 °C were 14.3 dB, −6.91 dB, −7.47 dB, and −8.51 dB, respectively. The experimental results also showed that the multiple-PVA system is more robust than a single PVA in a variable temperature environment from −10 °C to 50 °C. In conclusion, the use of multiple PVAs results in an effective, robust vibration control method for adaptive structures. (paper)

  17. Blowing jets as a circulation flow control to enhancement the lift of wing or generated power of wind turbine

    Directory of Open Access Journals (Sweden)

    Alexandru DUMITRACHE

    2014-06-01

    Full Text Available The goal of this paper is to provide a numerical flow analysis based on RANS equations in two directions: the study of augmented high-lift system for a cross-section airfoil of a wing up to transonic regime and the circulation control implemented by tangentially blowing jet over a highly curved surface due to Coanda effect on a rotor blade for a wind turbine. This study were analyzed the performance, sensitivities and limitations of the circulation control method based on blowing jet for a fixed wing as well as for a rotating wing. Directions of future research are identified and discussed.

  18. Feedback control of primary circulation pump of PIUS-Type reactor

    International Nuclear Information System (INIS)

    Fujii, Mikiya; Anoda, Yoshinari; Murata, Hideo; Yonomoto, Taisuke; Kukita, Yutaka; Tasaka, Kanji.

    1991-05-01

    In operating the PIUS-Type reactor, it is required to keep stationary density interfaces between the primary loop hot water and the poison tank cold, borated water by maintaining pressure balance between the primary-loop and the poison-tank. The authors have developed a primary circulation pump speed control system and tested it in small-scale experiments. This control system regulates the pump speed based on measurements of the density lock differential pressure which is proportional to the elevation of the interface in the density lock. This pump speed control facilitated the normal plant operation which included core power changes. However, the elevation of the density interface indicated oscillatory behavior when the pump speed was regulated as a linear function of the density lock differential pressure. The mechanism responsible for such oscillatory behavior was found to be manometric oscillations that could be eliminated by adding a damping term to compensate for the mechanical delay of the primary pump speed. The passive shutdown function of the reactor was retained by setting an upper limit to the pump speed. This was confirmed in a loss-of-feedwater abnormal transient test. (author)

  19. Control of breathing and the circulation in high-altitude mammals and birds.

    Science.gov (United States)

    Ivy, Catherine M; Scott, Graham R

    2015-08-01

    Hypoxia is an unremitting stressor at high altitudes that places a premium on oxygen transport by the respiratory and cardiovascular systems. Phenotypic plasticity and genotypic adaptation at various steps in the O2 cascade could help offset the effects of hypoxia on cellular O2 supply in high-altitude natives. In this review, we will discuss the unique mechanisms by which ventilation, cardiac output, and blood flow are controlled in high-altitude mammals and birds. Acclimatization to high altitudes leads to some changes in respiratory and cardiovascular control that increase O2 transport in hypoxia (e.g., ventilatory acclimatization to hypoxia). However, acclimatization or development in hypoxia can also modify cardiorespiratory control in ways that are maladaptive for O2 transport. Hypoxia responses that arose as short-term solutions to O2 deprivation (e.g., peripheral vasoconstriction) or regional variation in O2 levels in the lungs (i.e., hypoxic pulmonary vasoconstriction) are detrimental at in chronic high-altitude hypoxia. Evolved changes in cardiorespiratory control have arisen in many high-altitude taxa, including increases in effective ventilation, attenuation of hypoxic pulmonary vasoconstriction, and changes in catecholamine sensitivity of the heart and systemic vasculature. Parallel evolution of some of these changes in independent highland lineages supports their adaptive significance. Much less is known about the genomic bases and potential interactive effects of adaptation, acclimatization, developmental plasticity, and trans-generational epigenetic transfer on cardiorespiratory control. Future work to understand these various influences on breathing and circulation in high-altitude natives will help elucidate how complex physiological systems can be pushed to their limits to maintain cellular function in hypoxia. Copyright © 2014 Elsevier Inc. All rights reserved.

  20. Development and analysis of a variable position thermostat for smart cooling system of a light duty diesel vehicles and engine emissions assessment during NEDC

    International Nuclear Information System (INIS)

    Mohamed, Eid S.

    2016-01-01

    Highlights: • A new concept of the variable position electromagnetic thermostat in MCS is proposed. • A series of experiments were conducted on a light duty diesel vehicle operated over the NEDC test. • A comparative study was done on emission characteristics of the MCS and the conventional cooling system. • Engine cold start and steady-state coolant flow rate and emissions are presented. • The effect of MCS on engine accumulation FC and emissions over NEDC are evaluated. - Graphical Abstract: Display Omitted - Abstract: Smart cooling control systems for IC engines can better regulate the combustion process and heat, a variable position thermostat and electric coolant pumps (EWP) for IC engines are under development by a number of researchers. However, the aim of this study is to assess the performance of a variable position electromagnetic thermostat (VPEMT) to provide more flexible control of the engine temperature and coolant mass flow rate of modification cooling system (MCS). The measurement procedure was applied to two phases under new European drive cycle (NEDC) on a chassis dynamometer, with conventional cooling system (baseline engine) and MCS of a light duty diesel engine. The experimental results revealed that MCS using a VPEMT and EWP contributed to a reduction of engine warm-up period. As a consequence, important reduces in coolant flow rate and most exhaust emission compounds (THC, CO_2, CO and smoke opacity) were obtained. In contrast, NOx emission was observed to increase in these conditions. Comparative results are given for various engine speeds during a cold start and engine fully warm-up tests when the engine was equipped by conventional cooling system and MCS operation under NEDC, revealing the effect of MCS on engine fuel consumption and exhaust emissions.

  1. Leaching Behavior of Circulating Fluidised Bed MSWI Air Pollution Control Residue in Washing Process

    Directory of Open Access Journals (Sweden)

    Zhiliang Chen

    2016-09-01

    Full Text Available In this study, air pollution control (APC residue is conducted with water washing process to reduce its chloride content. A novel electrical conductivily (EC measurement method is proposed to monitor the dynamic change of chloride concentrations in leachate as well as the chloride content of the residue. The method equally applies to various washing processes with different washing time, liquid/solid ratio and washing frequency. The results show that washing effectively extracts chloride salts from APC residues, including those from circulating fluidized bed (CFB municipal solid waste incineration (MSWI. The most appropriate liquid/solid ratio and washing time in the first washing are found to be around 4 L water per kg of APC residue and 30 min, respectively, and washing twice is required to obtain maximum dissolution. The pH value is the major controlling factor of the heavy metals speciation in leachate, while chloride concentration also affects the speciation of Cd. Water washing causes no perceptible transfer of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs from the APC residue to leachate. The chloride concentration is strongly related with electrical conductivity (EC, as well as with the concentrations of calcium, sodium and potassium of washing water. Their regression analyses specify that soluble chloride salts and EC could act as an indirect indicator to monitor the change of chloride concentration and remaining chloride content, thus, contributing to the selection of the optimal washing conditions.

  2. Operation and control strategies in pre-series testing of cold circulating pumps for ITER

    International Nuclear Information System (INIS)

    Bhattacharya, R.; Vaghela, H.; Sarkar, B.; Srinivas, M.; Choukekar, K.

    2013-01-01

    Cryo-distribution system of ITER is responsible for the distribution and control of forced-flow supercritical helium for cooling of the superconducting magnets and the cryo-pumps. The requirements of cold circulating pumps (CCP) for mass flow rates and performance are much higher than presently existing and commercially available one used at 4.0 K helium. Design up-scaling with pre-series test of CCP has been proposed including test infrastructure. Operation and control strategies for the test distribution box (TDB) of test infrastructure have been developed and analyzed using steady state and dynamic process simulation to cope with the functional requirements of CCPs. Off-normal scenario with CCP inlet pressure variation is an important concern, dynamic process responses during such scenario have been evaluated to verify the operability of CCP. The paper describes process simulation to cope with the functional requirements of CCPs along with evaluation of off-normal scenario to verify the operability of CCP. (author)

  3. Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls.

    Science.gov (United States)

    Taylor, Brandie D; Tang, Gong; Ness, Roberta B; Olsen, Jørn; Hougaard, David M; Skogstrand, Kristin; Roberts, James M; Haggerty, Catherine L

    2016-01-01

    To determine if mid-pregnancy circulating immune biomarkers are associated with preeclampsia. Nested case-control study of 410 preeclamptic women and 297 normotensive controls with primiparous singleton pregnancies enrolled in the Danish National Birth Cohort. The mean gestational age in our cohort is 16 weeks (range 9-26). Preeclampsia was defined by blood pressure ⩾140/90 mmHg and proteinuria ⩾3 g/24 h. Serum immune biomarkers included interleukin (IL)-6, IL-6 receptor, IL-4, IL-4 receptor, IL-5, IL-12, IL-2, TNF-α, TNF-β, TNF-receptor, IL-1β, IL-1α, IL-8, IL-10, IFN-γ, IL-18, macrophage migration inhibitory factor, macrophage inflammatory protein, transforming growth factor-beta (TGF-β), and RANTES. Associations with preeclampsia, term preeclampsia and preterm preeclampsia were determined using two logistic regression models; (1) biomarkers were dichotomized by the limit of detection (LOD); (2) on the continuous scale, non-detectable values were imputed by LOD/2 and transformed (base 2). All models were adjusted for body mass index and smoking. IL1β was significantly associated with a decrease in the log odds of preeclampsia (p=0.0065), term preeclampsia (p=0.0230) and preterm preeclampsia (p=0.0068). Results were similar for IL4r and preeclampsia (p=0.0383). In the dichotomized models, detectable TNF-β was significantly associated with preeclampsia (ORadj 1.6, 95% CI 1.1-2.3) and term preeclampsia (OR 1.7, 95% CI 1.1-2.5) but not preterm preeclampsia. Detectable IL6 was significantly with term preeclampsia only (OR 1.5, 95% CI 1.1-2.2). Mid-pregnancy circulating IL1β, IL4r, IL6, and TNFβ were associated with preeclampsia. However, results were not consistent across statistical models. As the relationship is complex, future studies should explore cytokine clusters in preeclampsia risk. Copyright © 2015 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

  4. Restored Circulating Invariant NKT Cells Are Associated with Viral Control in Patients with Chronic Hepatitis B

    Science.gov (United States)

    Jiang, Xiaotao; Zhang, Mingxia; Lai, Qintao; Huang, Xuan; Li, Yongyin; Sun, Jian; Abbott, William G.H.; Ma, Shiwu; Hou, Jinlin

    2011-01-01

    Invariant NKT (iNKT) cells are involved in the pathogenesis of various infectious diseases. However, their role in hepatitis B virus (HBV) infection is not fully understood, especially in human species. In this study, 35 chronic hepatitis B (CHB) patients, 25 inactive carriers (IC) and 36 healthy controls (HC) were enrolled and the proportions of circulating iNKT cells in fresh isolated peripheral blood mononuclear cells (PBMC) were detected by flow cytometry. A longitudinal analysis was also conducted in 19 CHB patients who received antiviral therapy with telbivudine. Thereafter, the immune functions of iNKT cells were evaluated by cytokine secretion and a two-chamber technique. The median frequency of circulating iNKT cells in CHB patients (0.13%) was lower than that in HC (0.24%, P = 0.01) and IC (0.19%, P = 0.02), and increased significantly during antiviral therapy with telbivudine (P = 0.0176). The expressions of CC chemokine receptor 5 (CCR5) and CCR6 were dramatically higher on iNKT cells (82.83%±9.87%, 67.67%±16.83% respectively) than on conventional T cells (30.5%±5.65%, 14.02%±5.92%, both P<0.001) in CHB patients. Furthermore, iNKT cells could migrate toward the CC chemokine ligand 5. Patients with a high ratio (≥1.0) of CD4−/CD4+ iNKT cells at baseline had a higher rate (58.33%) of HBeAg seroconversion than those with a low ratio (<1.0, 0%, P = 0.0174). In conclusion, there is a low frequency of peripheral iNKT cells in CHB patients, which increases to normal levels with viral control. The ratio of CD4−/CD4+ iNKT cells at baseline may be a useful predictor for HBeAg seroconversion in CHB patients on telbivudine therapy. PMID:22194934

  5. The circulating cell-free microrna profile in systemic sclerosis is distinct from both healthy controls and Systemic Lupus Erythematosus

    DEFF Research Database (Denmark)

    Steen, S. O.; Iversen, L. V.; Carlsen, A. L.

    2015-01-01

    Objective. To evaluate the expression profile of cell-free circulating microRNA (miRNA) in systemic sclerosis (SSc), healthy controls (HC), and systemic lupus erythematosus (SLE). Methods. Total RNA was purified from plasma and 45 different, mature miRNA were measured using quantitative PCR assays...

  6. Electrodeposition of nickel onto steel, using a thermostatic cell and movable anode by a variable current

    International Nuclear Information System (INIS)

    Vega G, J.D.

    1994-01-01

    In this work, metallic coatings of nickel was made over carbon steel using two different electrolytic solutions: The Watts's bath and the nickel sulfamate bath, using a pulse variable current. The method use was the traditional method, its means a thermostatic cell and one movable anode, which is a few know technique nowadays, it allow realize depositions away from any laboratory or special workshop, it has the advantage to be a portable dispositive. At last of all the electro depositions the coatings quality was valuable by them physical properties like: adhesion, hardness, wrinkled and thickness. The best results was obtain by the Nickel sulfamate bath and movable anode, less in the thickness, which has higher on the thermostatic cell. The variable current was obtain by a Pulse Generator and a Cathodic galvanometer. (Author)

  7. Evaluating functions of positive-definite matrices using colored-noise thermostats

    Science.gov (United States)

    Nava, Marco; Ceriotti, Michele; Dryzun, Chaim; Parrinello, Michele

    2014-02-01

    Many applications in computational science require computing the elements of a function of a large matrix. A commonly used approach is based on the the evaluation of the eigenvalue decomposition, a task that, in general, involves a computing time that scales with the cube of the size of the matrix. We present here a method that can be used to evaluate the elements of a function of a positive-definite matrix with a scaling that is linear for sparse matrices and quadratic in the general case. This methodology is based on the properties of the dynamics of a multidimensional harmonic potential coupled with colored-noise, generalized Langevin equation thermostats. This "f-thermostat" approach allows us to calculate directly elements of functions of a positive-definite matrix by carefully tailoring the properties of the stochastic dynamics. We demonstrate the scaling and the accuracy of this approach for both dense and sparse problems and compare the results with other established methodologies.

  8. Capillary Tube and Thermostatic Expansion Valve Comparative Analysis in Water Chiller Air Conditioning

    Science.gov (United States)

    Wijaya Sunu, Putu; Made Rasta, I.; Anakottapary, Daud Simon; Made Suarta, I.; Cipta Santosa, I. D. M.

    2018-01-01

    The aims of this study to compares the performance characteristics of a water chiller air conditioning simulation equipped with thermostatic expansion valve (TEV) with those of a capillary tube. Water chiller system filled with the same charge of refrigerant. Comparative analyses were performed based on coefficient of performance (COP) and performance parameter of the refrigeration system, carried out at medium cooling load level with the ambient temperature of 29-31°C, constant compressor speed and fixed chilled water volume flowrate at 15 lpm. It was shown that the TEV system showed better energy consumption compared to that of capillary tube. From the coefficient of performance perspective, the thermostatic expansion valve system showed higher COP (± 21.4%) compared to that of capillary tube system.

  9. How the Invisible Hand is Supposed to Adjust the Natural Thermostat: A Guide for the Perplexed

    OpenAIRE

    Storm, Servaas

    2016-01-01

    Mainstream climate economics takes global warming seriously, but perplexingly concludes that the optimal economic policy is to almost do nothing about it. This conclusion can be traced to just a few “normative” assumptions, over which there exists fundamental disagreement amongst economists. This paper explores two axes of this disagreement. The first axis (“market vs. regulation”) measures faith in the invisible hand to adjust the natural thermostat. The second axis expresses differences in ...

  10. Quantum Oscillator in the Thermostat as a Model in the Thermodynamics of Open Quantum Systems

    OpenAIRE

    Sukhanov, Aleksander

    2005-01-01

    The quantum oscillator in the thermostat is considered as the model of an open quantum system. Our analysis will be heavily founded on the use of the Schroedinger generalized uncertainties relations (SUR). Our first aim is to demonstrate that for the quantum oscillator the state of thermal equilibrium belongs to the correlated coherent states (CCS), which imply the saturation of SUR at any temperature. The obtained results open the perspective for the search of some statistical theory, which ...

  11. RETRAN-02 analysis of upper head cooling during controlled natural circulation cooldown of Yankee Nuclear Power Station

    International Nuclear Information System (INIS)

    Fujita, N.; Helrich, R.E.; Bergeron, P.A.

    1982-01-01

    RETRAN-02 is particularly well-suited for investigating the fluid conditions in the upper head during a natural circulation cooldown. The RETRAN input model was developed with four basic objectives: (1) accurate description of the upper head cooling mechanisms; (2) proper simulation of natural circulation; (3) respresentations of operator actions required to proceed from full-power to shutdown-cooling-system conditions using both automatic and manual controls; and (4) reduction of the computer cost of simulating this evolution of approximately 10-hour duration. The response of the upper head fluid temperature calculated by RETRAN was in close agreement with measured data obtained from a natural circulation cooldown experiment performed for the Connecticut Yankee Plant, whose design is very similar to the Yankee Nuclear Power Station

  12. Properties of Controlled Low Strength Material with Circulating Fluidized Bed Combustion Ash and Recycled Aggregates

    Science.gov (United States)

    Weng, Tsai-Lung; Cheng, An; Chao, Sao-Jeng; Hsu, Hui-Mi

    2018-01-01

    This study aims to investigate the effect of adding circulating fluidized bed combustion (CFBC) ash, desulfurization slag, air-cooled blast-furnace slag and coal bottom ash to the controlled low-strength material (CLSM). Test methods include slump flow test, ball drop test, water soluble chloride ion content measurement, compressive strength and length change measurement. The results show that (1) the use of CFBC hydration ash with desulfurization slag of slump flow is the best, and the use of CFBC hydration ash with coal bottom ash and slump flow is the worst; (2) CFBC hydration ash with desulfurization slag and chloride ion content is the highest; (3) 24 h ball drop test (diameter ≤ 76 mm), and test results are 70 mm to 76 mm; (4) CFBC hydration ash with desulfurization slag and compression strength is the highest, with the coal bottom ash being the lowest; increase of CFBC hydration ash can reduce compressive strength; and (5) the water-quenched blast furnace slag and CFBC hydration ash would expand, which results in length changes of CLSM specimens. PMID:29724055

  13. Data on individual PCR efficiency values as quality control for circulating miRNAs

    Directory of Open Access Journals (Sweden)

    Anna Brunet-Vega

    2015-12-01

    Full Text Available This data article contains data related to the research article entitled “Variability in microRNA recovery from plasma: Comparison of five commercial kits, doi:10.1016/j.ab.2015.07.018” Brunet-Vega (2015 [1]. PCR efficiency, along with RNA and cDNA quality, are the most important factors affecting the quality of qPCR results. Constant amplification efficiency in all compared samples is indispensable when relative quantification is used to measure changes in gene expression. An easy way to measure PCR efficiency, without the need of a standard curve, is LinRegPCR software. Individual PCR efficiency can be determined as a part of qPCR quality control. This is especially important when the initial RNA quantity is so low that cannot be accurately quantified, such as in circulating RNA extractions. This data article reports the Cqs and PCR efficiencies of 5 miRNAs quantified in RNA isolated from 4 patients with colorectal cancer (CRC and 4 healthy donors using five commercially available kits.

  14. A thermostatted kinetic theory model for event-driven pedestrian dynamics

    Science.gov (United States)

    Bianca, Carlo; Mogno, Caterina

    2018-06-01

    This paper is devoted to the modeling of the pedestrian dynamics by means of the thermostatted kinetic theory. Specifically the microscopic interactions among pedestrians and an external force field are modeled for simulating the evacuation of pedestrians from a metro station. The fundamentals of the stochastic game theory and the thermostatted kinetic theory are coupled for the derivation of a specific mathematical model which depicts the time evolution of the distribution of pedestrians at different exits of a metro station. The perturbation theory is employed in order to establish the stability analysis of the nonequilibrium stationary states in the case of a metro station consisting of two exits. A general sensitivity analysis on the initial conditions, the magnitude of the external force field and the number of exits is presented by means of numerical simulations which, in particular, show how the asymptotic distribution and the convergence time are affected by the presence of an external force field. The results show how, in evacuation conditions, the interaction dynamics among pedestrians can be negligible with respect to the external force. The important role of the thermostat term in allowing the reaching of the nonequilibrium stationary state is stressed out. Research perspectives are underlined at the end of paper, in particular for what concerns the derivation of frameworks that take into account the definition of local external actions and the introduction of the space and velocity dynamics.

  15. A unified thermostat scheme for efficient configurational sampling for classical/quantum canonical ensembles via molecular dynamics

    Science.gov (United States)

    Zhang, Zhijun; Liu, Xinzijian; Chen, Zifei; Zheng, Haifeng; Yan, Kangyu; Liu, Jian

    2017-07-01

    We show a unified second-order scheme for constructing simple, robust, and accurate algorithms for typical thermostats for configurational sampling for the canonical ensemble. When Langevin dynamics is used, the scheme leads to the BAOAB algorithm that has been recently investigated. We show that the scheme is also useful for other types of thermostats, such as the Andersen thermostat and Nosé-Hoover chain, regardless of whether the thermostat is deterministic or stochastic. In addition to analytical analysis, two 1-dimensional models and three typical real molecular systems that range from the gas phase, clusters, to the condensed phase are used in numerical examples for demonstration. Accuracy may be increased by an order of magnitude for estimating coordinate-dependent properties in molecular dynamics (when the same time interval is used), irrespective of which type of thermostat is applied. The scheme is especially useful for path integral molecular dynamics because it consistently improves the efficiency for evaluating all thermodynamic properties for any type of thermostat.

  16. GREENHOUSE GAS EMISSIONS CONTROL BY OXYGEN FIRING IN CIRCULATING FLUIDIZED BED BOILERS

    Energy Technology Data Exchange (ETDEWEB)

    Nsakala ya Nsakala; Gregory N. Liljedahl

    2003-05-15

    Department of Energy National Energy Technology Laboratory (DOE) in 2001 to carry out a project entitled ''Greenhouse Gas Emissions Control by Oxygen Firing in Circulating Fluidized Bed Boilers.'' This two-phased project is in effect from September 28, 2001, to October 27, 2004. (U.S. DOE NETL Cooperative Agreement No. DE-FC26-01NT41146). Phase I consisted of an evaluation of the technical feasibility and economics of alternate CO{sub 2} capture technologies applied to Greenfield US coal-fired electric generation power plants, and supporting bench-scale testing. And Phase II consists of pilot-scale testing, supporting a refined performance and economic evaluation of the oxygen-fired AFC concept. Phase I, detailed in this report, entails a comprehensive study evaluating the technical feasibility and economics of alternate CO{sub 2} capture technologies applied to Greenfield US coal-fired electric generation power plants. Thirteen separate but related cases (listed below), representing various levels of technology development, were evaluated as described herein. The first seven cases represent coal combustion cases in CFB type equipment. The next four cases represent Integrated Gasification Combined Cycle (IGCC) systems. The last two cases represent advanced Chemical Looping systems, which were completely paid for by ALSTOM and included herein for completeness.

  17. VOC emission control by circulating fluidized bed adsorption; Controle de l'emission de composes organiques volatils par adsorption en lit fluidise circulant

    Energy Technology Data Exchange (ETDEWEB)

    Song, W.

    2003-12-15

    This work deals with the circulating fluidized bed technology, applied to the elimination by adsorption of volatile organic compounds (VOCs), like toluene, in a gas flow. In the process, the adsorbent (millimetric spherical grains of micro-porous carbon) is moved by a strong flow rate of gas inside a vertical tube without lining. Mass and heat transfers are very important and important volumes of compounds can be processed. This work presents the determination of the adsorption equilibrium, the description of the experimental facility and of the results of experiments, the development of an original model of the process which combines a flow model and a mass transfer model, a parametric study of this model, and finally, some extensions of the process principle to staged operations with pressure variation or temperature variation cycles. (J.S.)

  18. Interactions Between Indirect DC-Voltage Estimation and Circulating Current Controllers of MMC-Based HVDC Transmission Systems

    DEFF Research Database (Denmark)

    Wickramasinghe, Harith R.; Konstantinou, Georgios; Pou, Josep

    2018-01-01

    Estimation-based indirect dc-voltage control in MMCs interacts with circulating current control methods. This paper proposes an estimation-based indirect dc-voltage control method for MMC-HVDC systems and analyzes its performance compared to alternative estimations. The interactions between......-state and transient performance is demonstrated using a benchmark MMC-HVDC transmission system, implemented in a real-time digital simulator. The results verify the theoretical evaluations and illustrate the operation and performance of the proposed indirect dc-voltage control method....

  19. Setting the global thermostat with an exhaustible tradeable permit system

    International Nuclear Information System (INIS)

    Kosobud, R.G.; Quinn, K.G.; Illinois Univ., Chicago, IL; South, D.W.; Daly, T.A.

    1993-01-01

    The global warming policy debate has centered largely on near-term objectives such as freezing 1990 CO 2 emissions without regard to long-run implications. A policy of freezing CO 2 emissions is shown to slow but not halt global warming, while requiring expensive near-term adjustments. If the long-run temperature change outcome of the freeze policy is set as the goal of a more graduated control policy, one which allows the market to determine annual emissions, a more cost-effective solution is obtained that reduces the negative adjustment effects on the energy and other affected industries. The most cost-effective emissions time path of a graduated control policy could be achieved by an evaporative marketable CO 2 emissions permit system. This paper provides a preliminary examination of an evaporative permit system used to achieve long-run stabilization of greenhouse-induced temperature change

  20. Establishment of an Environmental Control Technology Laboratory with a Circulating Fluidized-Bed Combustion System

    Energy Technology Data Exchange (ETDEWEB)

    Wei-Ping Pan; Yan Cao; John Smith

    2008-05-31

    On February 14, 2002, President Bush announced the Clear Skies Initiative, a legislative proposal to control the emissions of nitrogen oxides (NO{sub x}), sulfur dioxide (SO{sub 2}), and mercury from power plants. In response to this initiative, the National Energy Technology Laboratory organized a Combustion Technology University Alliance and hosted a Solid Fuel Combustion Technology Alliance Workshop. The workshop identified multi-pollutant control; improved sorbents and catalysts; mercury monitoring and capture; and improved understanding of the underlying reaction chemistry occurring during combustion as the most pressing research needs related to controlling environmental emissions from fossil-fueled power plants. The Environmental Control Technology Laboratory will help meet these challenges and offer solutions for problems associated with emissions from fossil-fueled power plants. The goal of this project was to develop the capability and technology database needed to support municipal, regional, and national electric power generating facilities to improve the efficiency of operation and solve operational and environmental problems. In order to effectively provide the scientific data and the methodologies required to address these issues, the project included the following aspects: (1) Establishing an Environmental Control Technology Laboratory using a laboratory-scale, simulated fluidized-bed combustion (FBC) system; (2) Designing, constructing, and operating a bench-scale (0.6 MW{sub th}), circulating fluidized-bed combustion (CFBC) system as the main component of the Environmental Control Technology Laboratory; (3) Developing a combustion technology for co-firing municipal solid waste (MSW), agricultural waste, and refuse-derived fuel (RDF) with high sulfur coals; (4) Developing a control strategy for gaseous emissions, including NO{sub x}, SO{sub 2}, organic compounds, and heavy metals; and (5) Developing new mercury capturing sorbents and new

  1. Design, Development and Testing of a Drillable Straddle Packer for Lost Circulation Control in Geothermal Drilling

    Energy Technology Data Exchange (ETDEWEB)

    Gabaldon, J.; Glowka, D.A.; Gronewald, P.; Knudsen, S.D.; Raymond, D.W.; Staller, G.E.; Westmoreland, J.J.; Whitlow, G.L.; Wise, J.L.; Wright, E.K.

    1999-04-01

    Lost Circulation is a widespread problem encountered when drilling geothermal wells, and often represents a substantial portion of the cost of drilling a well. The U.S. Department of Energy sponsors research and development work at Sandia National Laboratories in an effort to reduce these lost circulation expenditures. Sandia has developed a down hole tool that improves the effectiveness and reduces th cost of lost circulation cement treatment while drilling geothermal wells. This tool, the Drillable Straddle Packer, is a low-cost disposable device that is used to isolate the loss zone and emplace the cement treatment directly into the region of concern. This report documents the design and development of the Drillabe Straddle Packer, the laboratory and field test results, and the design package that is available to transfer this technology to industry users.

  2. Thermostatic tissue platform for intravital microscopy: 'the hanging drop' model.

    Science.gov (United States)

    Pavlovic, Dragan; Frieling, Helge; Lauer, Kai-Stephan; Bac, Vo Hoai; Richter, Joern; Wendt, Michael; Lehmann, Christian; Usichenko, Taras; Meissner, Konrad; Gruendling, Matthias

    2006-11-01

    Intravital microscopy imposes the particular problem of the combined control of the body temperature of the animal and the local temperature of the observed organ or tissues. We constructed and tested, in the rat ileum microcirculation preparation, a new organ-support platform. The platform consisted of an organ bath filled with physiological solution, and contained a suction tube, a superfusion tube, an intestine-support hand that was attached to a micromanipulator and a thermometer probe. To cover the intestine we used a cover glass plate with a plastic ring glued on its upper surface. After a routine procedure (anaesthesia, monitoring and surgery), the intestine segment (2-3 cm long) was gently exteriorized and placed on the 'hand' of the organ support. A small part of the intestine formed a small 'island' in the bath that was filled with physiological salt solution. The cover glass was secured in place. The physiological salt solution from the superfusion tube, which was pointed to the lower surface of the cover glass, formed a 'hanging drop'. The objective of the microscope was then immersed into distilled water that was formed by the cover glass plastic ring. The 'hanging drop' technique prevented any tissue quenching, ensured undisturbed microcirculation, provided for stable temperature and humidity, and permitted a clear visual field.

  3. Computerized control of circulation. Optimal storage climate with minimal energy consumption. Pilot study; Computergestuurde Circulatieregelingen. Optimaal bewaarklimaat met minimaal energieverbruik. Praktijkonderzoek

    Energy Technology Data Exchange (ETDEWEB)

    Wildschut, J. [Praktijkonderzoek Plant en Omgeving PPO, Bloembollen, Boomkwekerij en Fruit, Lisse (Netherlands); Janssen, H.H.J.; Gielen, T.G.; Sapounas, A. [WUR Glastuinbouw, Wageningen (Netherlands)

    2011-04-15

    The objective of this study is to develop computerized controls for circulation that are based on sensors, allowing for significant conservation in the electricity use of circulation [Dutch] Doelstelling van dit project is het ontwikkelen van op sensoren gebaseerde computergestuurde regelingen voor de circulatie, waardoor bij een optimaal bewaarklimaat voor alle bolgewassen zeer fors op het elektraverbruik voor circulatie bespaard kan worden.

  4. Nuclear quantum effects in solids using a colored-noise thermostat.

    Science.gov (United States)

    Ceriotti, Michele; Bussi, Giovanni; Parrinello, Michele

    2009-07-17

    We present a method, based on a non-Markovian Langevin equation, to include quantum corrections to the classical dynamics of ions in a quasiharmonic system. By properly fitting the correlation function of the noise, one can vary the fluctuations in positions and momenta as a function of the vibrational frequency, and fit them so as to reproduce the quantum-mechanical behavior, with minimal a priori knowledge of the details of the system. We discuss the application of the thermostat to diamond and to ice Ih. We find that results in agreement with path-integral methods can be obtained using only a fraction of the computational effort.

  5. Thermal response of a Fermi-Pasta-Ulam chain with Andersen thermostats

    Science.gov (United States)

    D'Ambrosio, Federico; Baiesi, Marco

    2017-11-01

    The linear response to temperature variations is well characterised for equilibrium systems but a similar theory is not available, for example, for inertial heat conducting systems, whose paradigm is the Fermi-Pasta-Ulam (FPU) model driven by two different boundary temperatures. For models of inertial systems out of equilibrium, including relaxing systems, we show that Andersen thermostats are a natural tool for studying the thermal response. We derive a fluctuation-response relation that allows to predict thermal expansion coefficients or the heat capacitance in nonequilibrium regimes. Simulations of the FPU chain of oscillators suggest that estimates of susceptibilities obtained with our relation are better than those obtained via a small perturbation.

  6. Demand Response of Thermostatic Loads by Optimized Switching-Fraction Broadcast

    DEFF Research Database (Denmark)

    Totu, Luminita Cristiana; Wisniewski, Rafal

    2014-01-01

    Demand response is an important Smart Grid concept that aims at facilitating the integration of volatile energy resources into the electricity grid. This paper considers the problem of managing large populations of thermostat-based devices with on/off operation. The objective is to enable demand...... Method is used to spatially discretize these equations. Next, a broadcast strategy with two switching-fraction signals is proposed for actuating the population. This is applied in an open-loop scenario for tracking a power reference by running an optimization with a multilinear objective....

  7. Aerodynamic Response of a Pitching Airfoil with Pulsed Circulation Control for Vertical Axis Wind Turbine Applications

    Science.gov (United States)

    Panther, Chad C.

    Vertical Axis Wind Turbines (VAWTs) have experienced a renewed interest in development for urban, remote, and offshore applications. Past research has shown that VAWTs cannot compete with Horizontals Axis Wind Turbines (HAWTs) in terms of energy capture efficiency. VAWT performance is plagued by dynamic stall (DS) effects at low tip-speed ratios (lambda), where each blade pitches beyond static stall multiple times per revolution. Furthermore, for lambdaoperate outside of stall during over 70% of rotation. However, VAWTs offer many advantages such as omnidirectional operation, ground proximity of generator, lower sound emission, and non-cantilevered blades with longer life. Thus, mitigating dynamic stall and improving VAWT blade aerodynamics for competitive power efficiency has been a popular research topic in recent years and the directive of this study. Past research at WVU focused on the addition of circulation control (CC) technology to improve VAWT aerodynamics and expand the operational envelope. A novel blade design was generated from the augmentation of a NACA0018 airfoil to include CC capabilities. Static wind tunnel data was collected for a range of steady jet momentum coefficients (0.01≤ Cmu≤0.10) for analytical vortex model performance projections. Control strategies were developed to optimize CC jet conditions throughout rotation, resulting in improved power output for 2≤lambda≤5. However, the pumping power required to produce steady CC jets reduced net power gains of the augmented turbine by approximately 15%. The goal of this work was to investigate pulsed CC jet actuation to match steady jet performance with reduced mass flow requirements. To date, no experimental studies have been completed to analyze pulsed CC performance on a pitching airfoil. The research described herein details the first study on the impact of steady and pulsed jet CC on pitching VAWT blade aerodynamics. Both numerical and experimental studies were implemented, varying

  8. Thermal hydraulic aspects of steam drum level control philosophy for the natural circulation based heavy water reactor

    International Nuclear Information System (INIS)

    Gupta, S.K.; Gaikwad, A.J.; Kumar, Rajesh

    2004-01-01

    From safety considerations advanced nuclear reactors rely more and more on passive systems such as natural circulation for primary heat removal. A natural circulation based water reactor is relatively larger in size so as to reduce flow losses and channel type for proper flow distribution. From the size of steam drum considerations it has to be multi loop but has a common inlet header. Normally the turbine follows the reactor. This paper addresses the thermal hydraulic aspects of the steam drum pressure and level control philosophy for a four drum, natural circulation based, channel type boiling water advanced reactor. Three philosophies may be followed for drum control viz. individual drum control, one control drum approach and an average of all the four drums. For drum pressure control, the steam flow to the turbine is be regulated. A single point pressure control is better than individual drum pressure control. This is discussed in the paper. But the control point has to be at a place down steam the point where all steam line from individual drum meet. This may lead to different pressure in all the four drums depending on the power produced in the respective loops. The difference in pressure cannot be removed even if the four drums are directly connected through pipes. Also the pressure control scheme with/without interconnection is discussed. For level, the control of individual drum may not be normally possible because of common inlet header. As the frictional pressure drops in the large diameter downcomers are small as compared to elevation pressure drops, the level in all the steam drum tend to equalize. Consequently a single representative drum level may be chosen as a control variable for controlling level in all the four drums. But in case, where all the four loops are producing different powers and single point pressure control is effective, the scheme may not work satisfactorily. the level in a drum may depend on the power produced in the loop

  9. Flaviviruses in Europe: Complex Circulation Patterns and Their Consequences for the Diagnosis and Control of West Nile Disease

    Directory of Open Access Journals (Sweden)

    Elsa Jourdain

    2013-11-01

    Full Text Available In Europe, many flaviviruses are endemic (West Nile, Usutu, tick-borne encephalitis viruses or occasionally imported (dengue, yellow fever viruses. Due to the temporal and geographical co-circulation of flaviviruses in Europe, flavivirus differentiation by diagnostic tests is crucial in the adaptation of surveillance and control efforts. Serological diagnosis of flavivirus infections is complicated by the antigenic similarities among the Flavivirus genus. Indeed, most flavivirus antibodies are directed against the highly immunogenic envelope protein, which contains both flavivirus cross-reactive and virus-specific epitopes. Serological assay results should thus be interpreted with care and confirmed by comparative neutralization tests using a panel of viruses known to circulate in Europe. However, antibody cross-reactivity could be advantageous in efforts to control emerging flaviviruses because it ensures partial cross-protection. In contrast, it might also facilitate subsequent diseases, through a phenomenon called antibody-dependent enhancement mainly described for dengue virus infections. Here, we review the serological methods commonly used in WNV diagnosis and surveillance in Europe. By examining past and current epidemiological situations in different European countries, we present the challenges involved in interpreting flavivirus serological tests and setting up appropriate surveillance programs; we also address the consequences of flavivirus circulation and vaccination for host immunity.

  10. Examining the eastern Amazon Basin breeze circulations, channeling and boundary layer properties using altitude controlled meteorological balloons

    Science.gov (United States)

    Fitzjarrald, D. R.; Voss, P. B.; Silva, R. D.; Callahan, S.; Dewald, A.; do Vale, R. S.

    2017-12-01

    During the period August 24-28, 2016, in a delayed component the GO-Amazon Project, we launched nine altitude-controlled free balloons (CMET). Smaller than typical rawinsondes, CMET are equipped with altitude control, global communication via Iridium satellite, and aspirated sensors. The aims of our effort were to examine the interactions among convective boundary layer and dual river breeze circulations near the confluence of the Tapajos and Amazon Rivers in the eastern Basin. The week-long field campaign was timed to examine the reestablishment of the breeze circulations shortly after the passage of a strong instability line on August 22. Nine CMET were launched at the Curua-Una hydroelectric dam (2.8S; 54.3W), timed to encounter the Tapajos river breeze front by late afternoon. Soundings were made to establish the thickness of interface between the easterly trade and westerly Tapajos breeze circulation. Careful use of sounding strategies allowed these free balloons to track along the northerly channeled flow in the lowest 300 m above the River. Following the river encounter, balloons tracked to the west, sounding to describe the diurnal course of boundary layer in the forest west of the Tapajos River. The longest flight traveled more than 770 km over three days and twice rested overnight in the rain forest canopy. Ancillary data from surface climate and flux stations as well as the Santarem radiosonde, satellite images will be used to illustrate how the breeze circulations are seen near the surface and how they were disrupted by larger-scale events. Comparisons with HYSPLIT trajectories will illustrate how sensitive real trajectories are to the refraction that the encounter with the breeze effects.

  11. Characteristic Analysis and Fault-Tolerant Control of Circulating Current for Modular Multilevel Converters under Sub-Module Faults

    Directory of Open Access Journals (Sweden)

    Wen Wu

    2017-11-01

    Full Text Available A modular multilevel converter (MMC is considered to be a promising topology for medium- or high-power applications. However, a significantly increased amount of sub-modules (SMs in each arm also increase the risk of failures. Focusing on the fault-tolerant operation issue for the MMC under SM faults, the operation characteristics of MMC with different numbers of faulty SMs in the arms are analyzed and summarized in this paper. Based on the characteristics, a novel circulating current-suppressing (CCS fault-tolerant control strategy comprised of a basic control unit (BCU and virtual resistance compensation control unit (VRCCU in two parts is proposed, which has three main features: (i it can suppress the multi-different frequency components of the circulating current under different SM fault types simultaneously; (ii it can help fast limiting of the transient fault current caused at the faulty SM bypassed moment; and (iii it does not need extra communication systems to acquire the information of the number of faulty SMs. Moreover, by analyzing the stability performance of the proposed controller using the Root-Locus criterion, the election principle of the value of virtual resistance is revealed. Finally, the efficiency of the control strategy is confirmed with the simulation and experiment studies under different fault conditions.

  12. Bad Seeds Sprout Perilous Dynamics: Stochastic Thermostat Induced Trajectory Synchronization in Biomolecules.

    Science.gov (United States)

    Sindhikara, Daniel J; Kim, Seonah; Voter, Arthur F; Roitberg, Adrian E

    2009-06-09

    Molecular dynamics simulations starting from different initial conditions are commonly used to mimic the behavior of an experimental ensemble. We show in this article that when a Langevin thermostat is used to maintain constant temperature during such simulations, extreme care must be taken when choosing the random number seeds to prevent statistical correlation among the MD trajectories. While recent studies have shown that stochastically thermostatted trajectories evolving within a single potential basin with identical random number seeds tend to synchronize, we show that there is a synchronization effect even for complex, biologically relevant systems. We demonstrate this effect in simulations of alanine trimer and pentamer and in a simulation of a temperature-jump experiment for peptide folding of a 14-residue peptide. Even in replica-exchange simulations, in which the trajectories are at different temperatures, we find partial synchronization occurring when the same random number seed is employed. We explain this by extending the recent derivation of the synchronization effect for two trajectories in a harmonic well to the case in which the trajectories are at two different temperatures. Our results suggest several ways in which mishandling selection of a pseudorandom number generator initial seed can lead to corruption of simulation data. Simulators can fall into this trap in simple situations such as neglecting to specifically indicate different random seeds in either parallel or sequential restart simulations, utilizing a simulation package with a weak pseudorandom number generator, or using an advanced simulation algorithm that has not been programmed to distribute initial seeds.

  13. [New theory of holistic integrative physiology and medicine. III: New insight of neurohumoral mechanism and pattern of control and regulation for core axe of respiration, circulation and metabolism].

    Science.gov (United States)

    Sun, Xing-guo

    2015-07-01

    Systemic mechanism of neurohumoral control and regulation for human is limited. We used the new theory of holistic integrative physiology and medicine to approach the mechanism and pattern of neurohumoral control and regulation for life. As the core of human life, there are two core axes of functions. The first one is the common goal of respiration and circulation to transport oxygen and carbon dioxide for cells, and the second one is the goal of gastrointestinal tract and circulation to transport energy material and metabolic product for cells. These two core axes maintain the metabolism. The neurohumoral regulation is holistically integrated and unified for all functions in human body. We simplified explain the mechanism of neurohumoral control and regulation life (respiration and circulation) as the example pattern of sound system. Based upon integrated regulation of life, we described the neurohumoral pattern to control respiration and circulation.

  14. Impact of obesity control on circulating level of endothelial progenitor cells and angiogenesis in response to ischemic stimulation

    Directory of Open Access Journals (Sweden)

    Chen Yung-Lung

    2012-07-01

    Full Text Available Abstract Background and aim We tested the hypothesis that obesity reduced circulating number of endothelial progenitor cells (EPCs, angiogenic ability, and blood flow in ischemic tissue that could be reversed after obesity control. Methods 8-week-old C57BL/6J mice (n = 27 were equally divided into group 1 (fed with 22-week control diet, group 2 (22-week high fat diet, and group 3 (14-week high fat diet, followed by 8-week control diet. Critical limb ischemia (CLI was induced at week 20 in groups 2 and 3. The animals were sacrificed at the end of 22 weeks. Results Heart weight, body weight, abdominal fat weight, serum total cholesterol level, and fasting blood sugar were highest in group 2 (all p  Conclusion Obesity suppressed abilities of angiogenesis and recovery from CLI that were reversed by obesity control.

  15. Study on method and mechanism of deep well circulation for the growth control of Microcystis in aquaculture pond.

    Science.gov (United States)

    Cong, Haibing; Sun, Feng; Wu, Jun; Zhou, Yue; Yan, Qi; Ren, Ao; Xu, Hu

    2017-06-01

    In order to control the growth of Microcystis in aquaculture ponds and reduce its adverse effect on water quality and aquaculture, a production-scale experiment of deep well circulation treatment was carried out in an aquaculture pond with water surface area of 63,000 m 2 and water depth of 1.6-2.0 m. Compared with the control pond, the experiment pond had better water quality as indicated by 64.2% reduction in chlorophyll a, and 81.1% reduction in algal cells. The chemical oxygen demand, total nitrogen, and total phosphorus concentration were reduced by 55.1%, 57.5%, and 50.8%, respectively. The treatment efficiency is mainly due to the growth control of Microcystis (i.e. cell reduction of 96.4%). The gas vesicles collapsing because of the water pressure was suggested to be the mechanism for Microcystis suppression by the deep well circulation treatment. The Microcystis lost its buoyancy after gas vesicles collapsed and it settled to the bottom of the aquaculture pond. As a result, the algae reproduction was suppressed because algae could only grow in the area with enough sunlight (i.e. water depth less than 1 m).

  16. Investigation of some locally water-soluble natural polymers as circulation loss control agents during oil fields drilling

    Directory of Open Access Journals (Sweden)

    A.M. Alsabagh

    2014-03-01

    Full Text Available Eliminating or controlling lost circulation during drilling process is costly and time-consuming. Polymers play an important role in mud loss control for their viscosity due to their high molecular weight. In this paper, three natural cellulosic polymers (carboxymethyl cellulose, guar gum and potato starch were investigated as lost circulation control material by measuring different filtration parameters such as; spurt loss, fluid loss and permeability plugging tester value according to the American Petroleum Institute (API standard. The experiments were conducted in a permeability plugging apparatus (PPA at a differential pressure of 100 and 300 psi, using 10, 60 and 90 ceramic discs. From the obtained data, it was found that the 0.1% from the carboxymethyl cellulose exhibited the best results in the filtration parameters among 0.3% guar gum and 0.6% potato starch. At the same time the carboxymethyl cellulose (CMC enhanced the rheological properties of the drilling mud better than the two other used natural polymers in the term of gel strength, thixotropy, plastic and apparent viscosity. These results were discussed in the light of the adsorption and micellar formation.

  17. Bidecadal North Atlantic ocean circulation variability controlled by timing of volcanic eruptions.

    Science.gov (United States)

    Swingedouw, Didier; Ortega, Pablo; Mignot, Juliette; Guilyardi, Eric; Masson-Delmotte, Valérie; Butler, Paul G; Khodri, Myriam; Séférian, Roland

    2015-03-30

    While bidecadal climate variability has been evidenced in several North Atlantic paleoclimate records, its drivers remain poorly understood. Here we show that the subset of CMIP5 historical climate simulations that produce such bidecadal variability exhibits a robust synchronization, with a maximum in Atlantic Meridional Overturning Circulation (AMOC) 15 years after the 1963 Agung eruption. The mechanisms at play involve salinity advection from the Arctic and explain the timing of Great Salinity Anomalies observed in the 1970s and the 1990s. Simulations, as well as Greenland and Iceland paleoclimate records, indicate that coherent bidecadal cycles were excited following five Agung-like volcanic eruptions of the last millennium. Climate simulations and a conceptual model reveal that destructive interference caused by the Pinatubo 1991 eruption may have damped the observed decreasing trend of the AMOC in the 2000s. Our results imply a long-lasting climatic impact and predictability following the next Agung-like eruption.

  18. A 1260-year control integration with the coupled ECHAM1/LSG general circulation model

    Energy Technology Data Exchange (ETDEWEB)

    Storch, J.S. von [Hamburg Univ. (Germany). Meteorologisches Inst.; Kharin, V [Canadian Climate Centre, Victoria, BC (Canada); Cubasch, U [Deutsches Klimarechenzentrum (DKRZ), Hamburg (Germany); Hegerl, G C [Max-Planck-Institut fuer Meteorologie, Hamburg (Germany); Schriever, D [Max-Planck-Institut fuer Meteorologie, Hamburg (Germany); Storch, H von [GKSS-Forschungszentrum Geesthacht GmbH (Germany). Inst. fuer Hydrophysik; Zorita, E [GKSS-Forschungszentrum Geesthacht GmbH (Germany). Inst. fuer Hydrophysik

    1996-05-01

    A 1260-year integration generated by the ECHAM1/LSG coupled atmosphere-ocean general circulation model is analyzed in this paper. The analysis focuses on the time evolution of the model atmosphere and the model ocean, and on the variations of the final quasi-stationary atmosphere-ocean system. The evolution of the coupled system is affected by the globally integrated fluxes of heat and fresh water, the coupling shock induced by different types of fluxes prior to and after the coupling, and the insufficient spin-up of the deep ocean prior to the coupling. It is suggested that the flux correction with its unsatisfactory formulation over sea ice areas does not play the crucial role in causing the initial drift of the system. The main question concerning the atmospheric variations is whether the spatial structures of variations on short time scales are similar to those on long time scales. The answer to this question is yes. The questions concerning the oceanic variations are what are their dominant modes and to what extent are variations of different parts of the oceanic circulation related to each other. It is shown that the dominant oceanic variations are located in the North Pacific and at the southern flank of the mean position of the Antarctic Circumpolar Current and in the areas where deep water from three oceans meets the Antarctic Circumpolar Current. A correlation analysis indicates further that an anomalous outflow from (inflow into) the deep Atlantic is related to an anomalous outflow from (inflow into) the deep Indian Ocean and an anomalous eastward (westward) flow along the Antarctic coast. (orig.)

  19. Overview of Existing and Future Residential Use Cases for Connected Thermostats

    Energy Technology Data Exchange (ETDEWEB)

    Rotondo, Julia [Energetics Inc., Washington, DC (United States); Johnson, Robert [Energetics Inc., Washington, DC (United States); Gonzalez, Nancy [Energetics Inc., Washington, DC (United States); Waranowski, Alexandra [Energetics Inc., Washington, DC (United States); Badger, Chris [Vermont Energy Investment Corporation, Burlington, VT (United States); Lange, Nick [Vermont Energy Investment Corporation, Burlington, VT (United States); Goldman, Ethan [Vermont Energy Investment Corporation, Burlington, VT (United States); Foster, Rebecca [Vermont Energy Investment Corporation, Burlington, VT (United States)

    2017-03-01

    This paper is intended to help inform future technology deployment opportunities for connected thermostats (CTs), based on investigation and review of the U.S. residential housing and CT markets, as well as existing, emerging, and future use cases for CT hardware and CT-generated data. The CT market has experienced tremendous growth over the last 5 years—both in terms of the number of units sold and the number of firms offering competing products—and can be characterized by its rapid pace of technological innovation. Despite many assuming CTs would become powerful tools for increasing comfort while saving energy, there remains a great deal of uncertainty about the actual energy and cost savings that are likely to be realized from deployment of CTs, particularly under different conditions.

  20. Overview of Existing and Future Residential Use Cases for Connected Thermostats

    Energy Technology Data Exchange (ETDEWEB)

    Rotondo, Julia [Energetics Inc., Washington, DC (United States); Johnson, Robert [Energetics Inc., Washington, DC (United States); Gonzales, Nancy [Energetics Inc., Washington, DC (United States); Waranowski, Alexandra [Energetics Inc., Washington, DC (United States); Badger, Chris [Vermont Energy Investment Corp., Burlington, VT (United States); Lange, Nack [Vermont Energy Investment Corp., Burlington, VT (United States); Goldman, Ethan [Vermont Energy Investment Corp., Burlington, VT (United States); Foster, Rebecca [Vermont Energy Investment Corp., Burlington, VT (United States)

    2016-12-01

    This paper is intended to help inform future technology deployment opportunities for connected thermostats (CTs), based on investigation and review of the U.S. residential housing and CT markets, as well as existing, emerging, and future use cases for CT hardware and CT-generated data. The CT market has experienced tremendous growth over the last five years — both in terms of the number of units sold and the number of firms offering competing products — and can be characterized by its rapid pace of technological innovation. Despite many assuming CTs would become powerful tools for increasing comfort while saving energy, there remains a great deal of uncertainty about the actual energy and cost savings that are likely to be realized from deployment of CTs, particularly under different conditions.

  1. How the Invisible Hand is Supposed to Adjust the Natural Thermostat: A Guide for the Perplexed.

    Science.gov (United States)

    Storm, Servaas

    2017-10-01

    Mainstream climate economics takes global warming seriously, but perplexingly concludes that the optimal economic policy is to almost do nothing about it. This conclusion can be traced to just a few "normative" assumptions, over which there exists fundamental disagreement amongst economists. This paper explores two axes of this disagreement. The first axis ("market vs. regulation") measures faith in the invisible hand to adjust the natural thermostat. The second axis expresses differences in views on the efficiency and equity implications of climate action. The two axes combined lead to a classification of conflicting approaches in climate economics. The variety of approaches does not imply a post-modern "anything goes", as the contradictions between climate and capitalism cannot be wished away.

  2. Bad seeds sprout perilous dynamics: stochastic thermostat induced trajectory synchronization in biomolecules

    International Nuclear Information System (INIS)

    Voter, A. F.; Sindhikara, Daniel J.; Kim, Seonah; Roitberg, Adrian E.

    2009-01-01

    Molecular dynamics simulations starting from different initial conditions are commonly used to mimic the behavior of an experimental ensemble. We show in this article that when a Langevin thermostat is used to maintain constant temperature during such simulations, extreme care must be taken when choosing the random number seeds used in order to prevent statistical correlation among the MD trajectories. While recent studies have shown that stochastically thermostatted trajectories evolving within a single potential basin with identical random number seeds tend to synchronize, we show that there is a synchronization effect even for complex, biologically relevant systems. We demonstrate this effect in simulations of Alanine trimer and pentamer and in a simulation of a temperature-jump experiment for peptide folding of a 14-residue peptide. Even in replica-exchange simulations, in which the trajectories are at different temperatures, we find partial synchronization occurring when the same random number seed is employed. We explain this by extending the recent derivation of the synchronization effect for two trajectories in a harmonic well to the case in which the trajectories are at two different temperatures. Our results suggest several ways in which mishandling selection of a pseudo random number generator initial seed can lead to corruption of simulation data. Simulators can fall into this trap in simple situations such as neglecting to specifically indicate different random seeds in either parallel or sequential restart simulations, utilizing a simulation package with a weak pseudorandom number generator, or using an advanced simulation algorithm that hasn't been programmed to distribute initial seeds

  3. Circulating levels of cell-derived microparticles are reduced by mild hypobaric hypoxia: data from a randomised controlled trial.

    Science.gov (United States)

    Ayers, Lisa; Stoewhas, Anne-Christin; Ferry, Berne; Latshang, Tsogyal D; Lo Cascio, Christian M; Sadler, Ross; Stadelmann, Katrin; Tesler, Noemi; Huber, Reto; Achermann, Peter; Bloch, Konrad E; Kohler, Malcolm

    2014-05-01

    Hypoxia is known to induce the release of microparticles in vitro. However, few publications have addressed the role of hypoxia in vivo on circulating levels of microparticles. This randomised, controlled, crossover trial aimed to determine the effect of mild hypoxia on in vivo levels of circulating microparticles in healthy individuals. Blood was obtained from 51 healthy male volunteers (mean age of 26.9 years) at baseline altitude (490 m) and after 24 and 48 h at moderate altitude (2,590 m). The order of altitude exposure was randomised. Flow cytometry was used to assess platelet-poor plasma for levels of circulating microparticles derived from platelets, endothelial cells, leucocytes, granulocytes, monocytes, red blood cells and procoagulant microparticles. Mean (standard deviation) oxygen saturation was significantly lower on the first and second day after arrival at 2,590 m, 91.0 (2.0) and 92.0 (2.0) %, respectively, compared to 490 m, 96 (1.0) %, p microparticles (annexin V+ -221/μl 95 % CI -370.8/-119.0, lactadherin+ -202/μl 95 % CI -372.2/-93.1), platelet-derived microparticles (-114/μl 95 % CI -189.9/-51.0) and red blood cell-derived microparticles (-81.4 μl 95 % CI -109.9/-57.7) after 48 h at moderate altitude was found. Microparticles derived from endothelial cells, granulocytes, monocytes and leucocytes were not significantly altered by exposure to moderate altitude. In healthy male individuals, mild hypobaric hypoxia, induced by a short-term stay at moderate altitude, is associated with lower levels of procoagulant microparticles, platelet-derived microparticles and red blood cell-derived microparticles, suggesting a reduction in thrombotic potential.

  4. Development of the Circulation Control Flow Scheme Used in the NTF Semi-Span FAST-MAC Model

    Science.gov (United States)

    Jones, Gregory S.; Milholen, William E., II; Chan, David T.; Allan, Brian G.; Goodliff, Scott L.; Melton, Latunia P.; Anders, Scott G.; Carter, Melissa B.; Capone, Francis J.

    2013-01-01

    The application of a circulation control system for high Reynolds numbers was experimentally validated with the Fundamental Aerodynamic Subsonic Transonic Modular Active Control semi-span model in the NASA Langley National Transonic Facility. This model utilized four independent flow paths to modify the lift and thrust performance of a representative advanced transport type of wing. The design of the internal flow paths highlights the challenges associated with high Reynolds number testing in a cryogenic pressurized wind tunnel. Weight flow boundaries for the air delivery system were identified at mildly cryogenic conditions ranging from 0.1 to 10 lbm/sec. Results from the test verified system performance and identified solutions associated with the weight-flow metering system that are linked to internal perforated plates used to achieve flow uniformity at the jet exit.

  5. Enhanced haemolymph circulation by insect ventral nerve cord: hormonal control by Pseudaletia unipuncta allatotropin and serotonin.

    Science.gov (United States)

    Koladich, P M; Tobe, S S; McNeil, J N

    2002-10-01

    The ventral diaphragm (VD) in many insects is a muscular membrane that essentially partitions a perineural sinus from the rest of the abdomen. In the true armyworm moth Pseudaletia unipuncta (Lepidoptera: Noctuidae) we describe how the VD is characterized by a series of aliform muscles inserted into a tissue matrix that is fused to the dorsal surface of the ventral nerve cord (VNC) itself. Because of this arrangement, the abdominal VNC can attain high rates of lateral oscillation, and is capable of directing haemolymph flow. We have previously demonstrated Manduca sexta allatotropin (Manse-AT)-like immunoreactivity throughout the central nervous system (CNS) in P. unipuncta, and that both Manse-AT and serotonin (5-HT) are dose-dependent stimulators of the dorsal vessel. Here we describe both Manse-AT- and 5-HT-like immunoreactivity associated with the VD. Furthermore, both Manse-AT and 5-HT are dose-dependent stimulators of the rates of VNC oscillation, and together are capable of maintaining highly elevated rates of VNC oscillation for extended periods of time. These data indicate that both the dorsal vessel and the VD/VNC are similarly modulated by both Manse-AT and 5-HT, and that VNC oscillations play a more active role in overall haemolymph circulation than previously recognized.

  6. Circulation controls on southern African precipitation in coupled models: The role of the Angola Low

    Science.gov (United States)

    Munday, Callum; Washington, Richard

    2017-01-01

    In southern Africa, models from the latest Coupled Model Intercomparison Project produce a wide variety of rainfall climatologies. Differences between models in rainfall amount reach 70% in the rainy season (December-February; DJF), and the median model overestimates rainfall by between 15 and 40% throughout the annual cycle. This paper investigates the role of an understudied regional circulation feature, the Angola Low, in differentiating between model estimates of precipitation. In austral spring, the Angola Low is a heat low, driven by strong surface heating whereas in DJF it is more similar to a tropical low and is associated with moist instability. In the austral summer, we find that the simulated strength of the Angola Low is associated with between 40 and 60% of the intermodel variability in model mean rainfall across the subcontinent. The relationship is particularly strong along a northwest, southeast axis aligned from Angola down to the Mozambican Channel. Along this axis, models with stronger Angola Lows simulate enhanced, by up to 50 g kg-1 ms-1, northeasterly and northwesterly moisture transport. The enhanced southward moisture flux in models with relatively deep Angola Lows increases the rate of moisture convergence in central areas of the subcontinent and reduces moisture divergence across the Mozambican coast. The results highlight the need to better understand the links between the Angola Low and southern African rainfall and suggest that improving the simulation of the Angola Low can help to constrain model estimates of southern African rainfall.

  7. Learning Agent for a Heat-Pump Thermostat with a Set-Back Strategy Using Model-Free Reinforcement Learning

    Directory of Open Access Journals (Sweden)

    Frederik Ruelens

    2015-08-01

    Full Text Available The conventional control paradigm for a heat pump with a less efficient auxiliary heating element is to keep its temperature set point constant during the day. This constant temperature set point ensures that the heat pump operates in its more efficient heat-pump mode and minimizes the risk of activating the less efficient auxiliary heating element. As an alternative to a constant set-point strategy, this paper proposes a learning agent for a thermostat with a set-back strategy. This set-back strategy relaxes the set-point temperature during convenient moments, e.g., when the occupants are not at home. Finding an optimal set-back strategy requires solving a sequential decision-making process under uncertainty, which presents two challenges. The first challenge is that for most residential buildings, a description of the thermal characteristics of the building is unavailable and challenging to obtain. The second challenge is that the relevant information on the state, i.e., the building envelope, cannot be measured by the learning agent. In order to overcome these two challenges, our paper proposes an auto-encoder coupled with a batch reinforcement learning technique. The proposed approach is validated for two building types with different thermal characteristics for heating in the winter and cooling in the summer. The simulation results indicate that the proposed learning agent can reduce the energy consumption by 4%–9% during 100 winter days and by 9%–11% during 80 summer days compared to the conventional constant set-point strategy.

  8. Effect of Whey Supplementation on Circulating C-Reactive Protein: A Meta-Analysis of Randomized Controlled Trials

    Science.gov (United States)

    Zhou, Ling-Mei; Xu, Jia-Ying; Rao, Chun-Ping; Han, Shufen; Wan, Zhongxiao; Qin, Li-Qiang

    2015-01-01

    Whey supplementation is beneficial for human health, possibly by reducing the circulating C-reactive protein (CRP) level, a sensitive marker of inflammation. Thus, a meta-analysis of randomized controlled trials was conducted to evaluate their relationship. A systematic literature search was conducted in July, 2014, to identify eligible studies. Either a fixed-effects model or a random-effects model was used to calculate pooled effects. The meta-analysis results of nine trials showed a slight, but no significant, reduction of 0.42 mg/L (95% CI −0.96, 0.13) in CRP level with the supplementation of whey protein and its derivates. Relatively high heterogeneity across studies was observed. Subgroup analyses showed that whey significantly lowered CRP by 0.72 mg/L (95% CI −0.97, −0.47) among trials with a daily whey dose ≥20 g/day and by 0.67 mg/L (95% CI −1.21, −0.14) among trials with baseline CRP ≥3 mg/L. Meta-regression analysis revealed that the baseline CRP level was a potential effect modifier of whey supplementation in reducing CRP. In conclusion, our meta-analysis did not find sufficient evidence that whey and its derivates elicited a beneficial effect in reducing circulating CRP. However, they may significantly reduce CRP among participants with highly supplemental doses or increased baseline CRP levels. PMID:25671415

  9. Circulating IGF-I and IGFBP3 levels control human colonic stem cell function and are disrupted in diabetic enteropathy

    Science.gov (United States)

    Maestroni, Anna; Jung, Peter; Orsenigo, Elena; Nasr, Moufida Ben; Tezza, Sara; Bassi, Roberto; Finzi, Giovanna; Marando, Alessandro; Vergani, Andrea; Frego, Roberto; Albarello, Luca; Andolfo, Annapaola; Manuguerra, Roberta; Viale, Edi; Staudacher, Carlo; Corradi, Domenico; Batlle, Eduard; Breault, David; Secchi, Antonio; Folli, Franco; Fiorina, Paolo

    2016-01-01

    Summary The role of circulating factors in regulating colonic stem cells (CoSCs) and colonic epithelial homeostasis is unclear. Individuals with long-standing type 1 diabetes (T1D) frequently have intestinal symptoms, termed diabetic enteropathy (DE), though its etiology is unknown. Here, we report T1D patients with DE exhibit abnormalities in their intestinal mucosa and CoSCs, which fail to generate in vitro mini-guts. Proteomic profiling of T1D+DE patient serum revealed altered levels of insulin-like growth factor 1 (IGF-1) and its binding protein-3 (IGFBP3). IGFBP3 prevented in vitro growth of patient-derived organoids via binding its receptor TMEM219, in an IGF-1-independent manner, and disrupted in vivo CoSC function in a preclinical DE model. Restoration of normoglycemia in patients with long-standing T1D via kidney-pancreas transplantation or in diabetic mice by treatment with an ecto-TMEM219 recombinant protein normalized circulating IGF-1/IGFBP3 levels and reestablished CoSC homeostasis. These findings demonstrate that peripheral IGF-1/IGFBP3 control CoSCs and their dysfunction in DE. PMID:26431183

  10. An Enhanced Instantaneous Circulating Current Control for Reactive power and Harmonic Load Sharing in Islanded Microgrids

    DEFF Research Database (Denmark)

    Lorzadeh, Iman; Askarian Abyaneh, Hossein; Savaghebi, Mehdi

    2017-01-01

    To address inaccurate load demand sharing problems among parallel inverter-interfaced voltage-controlled distributed generation (DG) units in islanded microgrids with different DG power ratings and mismatched feeder impedances, an enhanced voltage control scheme based on actively compensation of ...

  11. Chaotic Phenomena in Technical Control Systems

    DEFF Research Database (Denmark)

    Mosekilde, Erik

    1997-01-01

    The paper discusses a number of examples of technical control systems that can exhibit deterministic chaos and other forms of complex nonlinear behavior. These examples include thermostatically regulated radiators, closely placed refrigirators, and industrial cooling compressors. The paper contin...

  12. Circulating sCD36 levels in patients with non-alcoholic fatty liver disease and controls

    DEFF Research Database (Denmark)

    Heebøll, Sara; Poulsen, Marianne Kjær; Ørnstrup, Marie Juul

    2017-01-01

    BACKGROUND AND OBJECTIVE: CD36 is implicated in fatty acid uptake in multiple tissues, including hepatocytes and adipocytes. Circulating CD36 (sCD36) is increased in non-alcoholic fatty liver disease (NAFLD).We explored this association further by investigating correlations between sCD36 levels...... resonance imaging (n=94, subcutaneous and visceral adipose tissue) and liver biopsy (n=28 NAFLD patients) performed. Plasma sCD36 was assessed by ELISA. RESULTS: NAFLD patients had elevated sCD36 levels compared to controls (0.68 (0.12-2.27) versus 0.43 (0.10-1.18), P.... An unhealthy and unbalanced CD36 expression in adipose and hepatic tissue may shift the fatty acid load to the liver.Clinical Trials.gov (NCT01464801, NCT01412645, NCT01446276).International Journal of Obesity accepted article preview online, 05 December 2016. doi:10.1038/ijo.2016.223....

  13. Investigation on multi-variable decoupled temperature control system for enamelling machine with heated air circulation

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yang; Qin, Le; Zou, Shipeng; Long, Shijun [School of Information Engineering, Guangdong University of Technology, Guangzhou, 510006 (China)

    2014-04-11

    A lots of problems may occur frequently when controlling the temperature of the enamelling machine oven in the real industrial process, such as multi-variable coupled problem. an experimental rig with triple inputs and triple outputs was devised and a simulation modeling was established accordingly in this study,. the temperature control system based on the feedforward compensation algorithm was proposed. Experimental results have shown that the system is of high efficiency, good stability and promising application.

  14. [New theory of holistic integrative physiology and medicine. II: New insight of the control and regulation of circulation].

    Science.gov (United States)

    Sun, Xing-guo

    2015-07-01

    The interpretation of control and regulation of circulatory parameters in traditional physiology has some limitations. Human being is an organic, circulatory control and regulation should involve all the systems. Based upon the theory of holistic integrative physiology and medicine, we approach to explain the circulatory control and regulation from its purpose. The main purpose of circulation is to maintain a stable metabolism of cells, i.e. transport oxygen (from lung) and nutrients (from gastrointestinal tract) to cells, and return carbon dioxide and metabolic products back for elimination. Based on this goal, all respiration and gastrointestinal digestion, absorption, urinary excretion, etc. are integrative together for regulation to maintain the supply-demand balance at any metabolic status of resting, exercise and sleep. So that, we can explain many existing problems and questions, for example: why and how the foramen ovale closed after birth; mechanism of Cheyne-Stokes respiration; blood flow redistribution during exercise; variabilities of systolic blood pressure, heart rate and autonomic tone. The circulatory control and regulation is the integration of all systems of the body.

  15. design of a decoupler controller for forced circulation evaporator used in a radioactive treatment plant

    International Nuclear Information System (INIS)

    Abdel-Halim, H.A.

    2005-01-01

    evaporation is a proven method for a treatment of liquid radioactive wastes providing both good decontamination and high concentration . in a radioactive waste treatment plant, an evaporator is used to reduce the volume of medium radioactive liquid waste arising from different applications of nuclear industries. the control system objective is to limit the composition of the liquid waste at a prescribed value. for the safe operation, without damaging the installed equipment, a good control for the evaporator operating pressure and the level of liquid waste inside the separator part has been required. evaporator equipment is a complex process, which is a multivariable, nonlinear and has many disturbances. therefore, design a control strategy for the evaporator is bit difficult. the solution method is based on system decoupling eliminating the parasite interactions between input-output pairing variables and converting multi-inputs multi-outputs (MIMO) system to several single-inputs single-outputs (SISO) systems

  16. Relationship of Circulating C5a and Complement Factor H Levels With Disease Control in Pregnant Women With Asthma.

    Science.gov (United States)

    Bohács, Anikó; Bikov, András; Ivancsó, István; Czaller, Ibolya; Böcskei, Renáta; Müller, Veronika; Rigó, János; Losonczy, György; Tamási, Lilla

    2016-04-01

    Asthma often complicates pregnancy and represents a risk of serious pregnancy complications. The complement system contributes to asthma pathogenesis and is up-regulated in healthy gestation as well. The anaphylatoxin C5a has a major pro-inflammatory role, and the complement factor H is a main soluble regulator protein both in asthma and during pregnancy; however, peripheral levels of these complement factors and their relationship to disease control have not yet been evaluated in pregnant subjects with asthma. The present study aimed to investigate circulating C5a and complement factor H levels in asthma (non-pregnant subjects with asthma; n = 19) and in pregnancy with asthma (pregnant subjects with asthma; n = 22), compared with healthy non-pregnant (n = 21) and healthy pregnant women (n = 13) and to test their relationship to clinical parameters of asthma (lung function, airway inflammation, and symptoms). Circulating C5a levels were higher in the pregnant asthma subject group compared with the healthy non-pregnant, healthy pregnant, and non-pregnant asthma groups: median 2.629 (interquartile range [IQR] 2.257-3.052) ng/mL versus 1.84 (IQR 1.576-2.563), 1.783 (IQR 0.6064-2.786), and 2.024 (IQR 1.232-2.615) ng/mL, respectively (P = .02 in all cases). C5a correlated negatively with FEV1 (r = -0.44, P = .039) and FVC values (r = -0.64, P = .001) in the pregnant asthma group and positively with fraction of exhaled nitric oxide levels in the non-pregnant asthma group (n = 12, r = 0.78, P = .004). Complement factor H levels were elevated in both the healthy pregnant and pregnant asthma subject groups compared with the healthy non-pregnant group (median 1,082 [IQR 734.9-1,224] and 910.7 [IQR 614.5-1076] μg/mL vs. 559.7 [IQR 388.7-783.1] μg/mL, P = .002 and P = .004, respectively) but not in the pregnant asthma group compared with the non-pregnant asthma group (median 687.4 [IQR 441.6-947.6] μg/mL, P = .10). Asthma during pregnancy increases the circulating level of

  17. Using billing and weather data to separate thermostat from insulation effects

    Energy Technology Data Exchange (ETDEWEB)

    Fels, M F; Goldberg, M L

    1984-05-01

    A simple methodology, which uses aggregate utility sales data to measure and decompose residential conservation trends, is demonstrated. The data base is the aggregate natural gas consumption of the nearly one million houses in New Jersey which use gas for heating. The conservation index resulting from the analysis is normalized annual consumption, which adjusts per-household consumption to typical weather conditions. To smooth erratic year-to-year changes, four-year composite analyses are moved forward in time over the period 1970-82. Dramatic decreases in consumption, totaling 26% since the oil embargo, are evident. A decomposition of the results for the four years following the embargo suggests that over half of this conservation effect is due to changes in interior temperatures, with the policy implication that thermostat setbacks have played a far greater conservation role than have either structural change through retrofitting or modifications in appliance usage. In more recent years, for which the overall reduction in energy usage is lower, the dominant conservation role appears to have shifted to reductions in temperature-independent, base-level consumption by water heaters and appliances, while the effects of retrofitting remain relatively small.

  18. Physiological levels of blood coagulation factors IX and X control coagulation kinetics in an in vitro model of circulating tissue factor

    International Nuclear Information System (INIS)

    Tormoen, Garth W; Khader, Ayesha; Gruber, András; McCarty, Owen J T

    2013-01-01

    Thrombosis significantly contributes to cancer morbidity and mortality. The mechanism behind thrombosis in cancer may be circulating tissue factor (TF), as levels of circulating TF are associated with thrombosis. However, circulating TF antigen level alone has failed to predict thrombosis in patients with cancer. We hypothesize that coagulation factor levels regulate the kinetics of circulating TF-induced thrombosis. Coagulation kinetics were measured as a function of individual coagulation factor levels and TF particle concentration. Clotting times increased when pooled plasma was mixed at or above a ratio of 4:6 with PBS. Clotting times increased when pooled plasma was mixed at or above a ratio of 8:2 with factor VII-depleted plasma, 7:3 with factor IX- or factor X-depleted plasmas, or 2:8 with factor II-, V- or VIII-depleted plasmas. Addition of coagulation factors VII, X, IX, V and II to depleted plasmas shortened clotting and enzyme initiation times, and increased enzyme generation rates in a concentration-dependent manner. Only additions of factors IX and X from low-normal to high-normal levels shortened clotting times and increased enzyme generation rates. Our results demonstrate that coagulation kinetics for TF particles are controlled by factor IX and X levels within the normal physiological range. We hypothesize that individual patient factor IX and X levels may be prognostic for susceptibility to circulating TF-induced thrombosis. (paper)

  19. Distributed parameter modeling and simulation for the evaporation system of a controlled circulation boiler based on 3-D combustion monitoring

    International Nuclear Information System (INIS)

    Chu Yuntao; Lou Chun; Cheng Qiang; Zhou Huaichun

    2008-01-01

    In this paper, a dynamic, distributed parameter model for the evaporation system of a controlled circulation boiler was developed. As an essential basis, the 3-D temperature distribution and the average emissivity of the particle phase inside its furnace can be got by a flame image processing technique from multiple, visible flame image detectors in a real-time combustion monitoring system. Then the transient, 2-D radiation flux can be obtained by solving a set of energy balance equations for the water wall elements, which serves as a distributed boundary condition for the dynamic, distributed parameter model proposed for the evaporation system. For large change of the boiler load, two important parameters, the correction factor of equivalent flame emissivity and the coefficient of the steam mass flow rate at the outlet of the drum, were determined using the operation data from a 300 MW boiler. The model was validated by comparing the simulation results for some main steam parameters of the system with those from measurements. Besides that, the transient distributions of the parameters, such as the steam quality and the mass velocity, were predicted by the model. This model can be used for on-line calculation or off-line prediction of the local abnormal phenomena occurring on the water walls, forming an important basis to effectively evaluate the security and the reliability of a power plant boiler

  20. Circulating microRNA levels predict residual beta cell function and glycaemic control in children with type 1 diabetes mellitus

    DEFF Research Database (Denmark)

    Samandari, Nasim; Mirza, Aashiq H; Nielsen, Lotte B

    2017-01-01

    AIMS/HYPOTHESIS: We aimed to identify circulating microRNA (miRNA) that predicts clinical progression in a cohort of 123 children with new-onset type 1 diabetes mellitus. METHODS: Plasma samples were prospectively obtained at 1, 3, 6, 12 and 60 months after diagnosis from a subset of 40 children......RNAs revealed significant enrichment for pathways related to gonadotropin-releasing hormone receptor and angiogenesis pathways. CONCLUSIONS/INTERPRETATION: The miRNA hsa-miR-197-3p at 3 months was the strongest predictor of residual beta cell function 1 year after diagnosis in children with type 1 diabetes...... from the Danish Remission Phase Cohort, and profiled for miRNAs. At the same time points, meal-stimulated C-peptide and HbA1c levels were measured and insulin-dose adjusted HbA1c (IDAA1c) calculated. miRNAs that at 3 months after diagnosis predicted residual beta cell function and glycaemic control...

  1. Evaluation of some natural water-insoluble cellulosic material as lost circulation control additives in water-based drilling fluid

    Directory of Open Access Journals (Sweden)

    Ahmed Mohamed Alsabagh

    2015-12-01

    In this work, three natural water-insoluble cellulosic materials; peanut hulls, bagasse and sawdust were investigated as lost circulation control materials. One hundred and eight different LCM samples made of various materials were tested with mud. The experiments were conducted in a permeability plugging apparatus (PPA at a differential pressure of 100 psi and 300 psi, using 10, 60 and 90 ceramic discs. The performance of each LCM sample was determined based on the amount of spurt loss and total fluid loss of the mud according to the American Petroleum Institute (API standard. The obtained results showed that, the amount of the fluid loss depends on the LCM material, concentration and size distribution, testing results show that, the peanut gives the best results among the bagasse and sawdust, especially fine size which exhibited better results in the filtration characteristics due to the better filling properties of this size. Peanut hulls, bagasse and sawdust show a slight effect on the rheological properties of the mud. The results were discussed on light of particle size distribution.

  2. Dynamic principle for ensemble control tools.

    Science.gov (United States)

    Samoletov, A; Vasiev, B

    2017-11-28

    Dynamical equations describing physical systems in contact with a thermal bath are commonly extended by mathematical tools called "thermostats." These tools are designed for sampling ensembles in statistical mechanics. Here we propose a dynamic principle underlying a range of thermostats which is derived using fundamental laws of statistical physics and ensures invariance of the canonical measure. The principle covers both stochastic and deterministic thermostat schemes. Our method has a clear advantage over a range of proposed and widely used thermostat schemes that are based on formal mathematical reasoning. Following the derivation of the proposed principle, we show its generality and illustrate its applications including design of temperature control tools that differ from the Nosé-Hoover-Langevin scheme.

  3. Enhancements to the FAST-MAC Circulation Control Model and Recent High-Reynolds Number Testing in the National Transonic Facility

    Science.gov (United States)

    Milholen, William E., II; Jones, Gregory S.; Chan, David T.; Goodliff, Scott L.; Anders, Scott G.; Melton, Latunia P.; Carter, Melissa B.; Allan, Brian G.; Capone, Francis J.

    2013-01-01

    A second wind tunnel test of the FAST-MAC circulation control model was recently completed in the National Transonic Facility at the NASA Langley Research Center. The model was equipped with four onboard flow control valves allowing independent control of the circulation control plenums, which were directed over a 15% chord simple-hinged flap. The model was configured for low-speed high-lift testing with flap deflections of 30 and 60 degrees, along with the transonic cruise configuration with zero degree flap deflection. Testing was again conducted over a wide range of Mach numbers up to 0.88, and Reynolds numbers up to 30 million based on the mean chord. The first wind tunnel test had poor transonic force and moment data repeatability at mild cryogenic conditions due to inadequate thermal conditioning of the balance. The second test demonstrated that an improvement to the balance heating system significantly improved the transonic data repeatability, but also indicated further improvements are still needed. The low-speed highlift performance of the model was improved by testing various blowing slot heights, and the circulation control was again demonstrated to be effective in re-attaching the flow over the wing at off-design transonic conditions. A new tailored spanwise blowing technique was also demonstrated to be effective at transonic conditions with the benefit of reduced mass flow requirements.

  4. AMELIA CESTOL Test: Acoustic Characteristics of Circulation Control Wing with Leading- and Trailing-Edge Slot Blowing

    Science.gov (United States)

    Horne, William C.; Burnside, Nathan J.

    2013-01-01

    The AMELIA Cruise-Efficient Short Take-off and Landing (CESTOL) configuration concept was developed to meet future requirements of reduced field length, noise, and fuel burn by researchers at Cal Poly, San Luis Obispo and Georgia Tech Research Institute under sponsorship by the NASA Fundamental Aeronautics Program (FAP), Subsonic Fixed Wing Project. The novel configuration includes leading- and trailing-edge circulation control wing (CCW), over-wing podded turbine propulsion simulation (TPS). Extensive aerodynamic measurements of forces, surfaces pressures, and wing surface skin friction measurements were recently measured over a wide range of test conditions in the Arnold Engineering Development Center(AEDC) National Full-Scale Aerodynamics Complex (NFAC) 40- by 80-Ft Wind Tunnel. Acoustic measurements of the model were also acquired for each configuration with 7 fixed microphones on a line under the left wing, and with a 48-element, 40-inch diameter phased microphone array under the right wing. This presentation will discuss acoustic characteristics of the CCW system for a variety of tunnel speeds (0 to 120 kts), model configurations (leading edge(LE) and/or trailing-edge(TE) slot blowing, and orientations (incidence and yaw) based on acoustic measurements acquired concurrently with the aerodynamic measurements. The flow coefficient, Cmu= mVSLOT/qSW varied from 0 to 0.88 at 40 kts, and from 0 to 0.15 at 120 kts. Here m is the slot mass flow rate, VSLOT is the slot exit velocity, q is dynamic pressure, and SW is wing surface area. Directivities at selected 1/3 octave bands will be compared with comparable measurements of a 2-D wing at GTRI, as will as microphone array near-field measurements of the right wing at maximum flow rate. The presentation will include discussion of acoustic sensor calibrations as well as characterization of the wind tunnel background noise environment.

  5. Circulation Systems Past and Present

    Directory of Open Access Journals (Sweden)

    Maurice J. Freedman

    1981-01-01

    Full Text Available A review of the development of circulation systems shows two areas of change. The librarian's perception of circulation control has shifted from a broad service orientation to a narrow record-keeping approach and recently back again. The technological development of circulation sys-tems has evolved from manual systems to the online systems of today. The trade-offs and deficiencies of earlier systems in relation to the comprehensive services made possible by the online computer are detailed.

  6. Effect of Vitamin D Supplementation on the Level of Circulating High-Sensitivity C-Reactive Protein: A Meta-Analysis of Randomized Controlled Trials

    Directory of Open Access Journals (Sweden)

    Neng Chen

    2014-06-01

    Full Text Available Vitamin D might elicit protective effects against cardiovascular disease by decreasing the level of circulating high-sensitivity C-reactive protein (hs-CRP, an inflammatory marker. Thus, we conducted a meta-analysis of randomized controlled trials to evaluate the association of vitamin D supplementation with circulating hs-CRP level. A systematic literature search was conducted in September 2013 (updated in February 2014 via PubMed, Web of Science, and Cochrane library to identify eligible studies. Either a fixed-effects or a random-effects model was used to calculate pooled effects. The results of the meta-analysis of 10 trials involving a total of 924 participants showed that vitamin D supplementation significantly decreased the circulating hs-CRP level by 1.08 mg/L (95% CI, −2.13, −0.03, with the evidence of heterogeneity. Subgroup analysis suggested a higher reduction of 2.21 mg/L (95% CI, −3.50, −0.92 among participants with baseline hs-CRP level ≥5 mg/L. Meta-regression analysis further revealed that baseline hs-CRP level, supplemental dose of vitamin D and intervention duration together may be attributed to the heterogeneity across studies. In summary, vitamin D supplementation is beneficial for the reduction of circulating hs-CRP. However, the result should be interpreted with caution because of the evidence of heterogeneity.

  7. Effect of vitamin D supplementation on the level of circulating high-sensitivity C-reactive protein: a meta-analysis of randomized controlled trials.

    Science.gov (United States)

    Chen, Neng; Wan, Zhongxiao; Han, Shu-Fen; Li, Bing-Yan; Zhang, Zeng-Li; Qin, Li-Qiang

    2014-06-10

    Vitamin D might elicit protective effects against cardiovascular disease by decreasing the level of circulating high-sensitivity C-reactive protein (hs-CRP), an inflammatory marker. Thus, we conducted a meta-analysis of randomized controlled trials to evaluate the association of vitamin D supplementation with circulating hs-CRP level. A systematic literature search was conducted in September 2013 (updated in February 2014) via PubMed, Web of Science, and Cochrane library to identify eligible studies. Either a fixed-effects or a random-effects model was used to calculate pooled effects. The results of the meta-analysis of 10 trials involving a total of 924 participants showed that vitamin D supplementation significantly decreased the circulating hs-CRP level by 1.08 mg/L (95% CI, -2.13, -0.03), with the evidence of heterogeneity. Subgroup analysis suggested a higher reduction of 2.21 mg/L (95% CI, -3.50, -0.92) among participants with baseline hs-CRP level ≥5 mg/L. Meta-regression analysis further revealed that baseline hs-CRP level, supplemental dose of vitamin D and intervention duration together may be attributed to the heterogeneity across studies. In summary, vitamin D supplementation is beneficial for the reduction of circulating hs-CRP. However, the result should be interpreted with caution because of the evidence of heterogeneity.

  8. Effect of dietary fiber on circulating C-reactive protein in overweight and obese adults: a meta-analysis of randomized controlled trials.

    Science.gov (United States)

    Jiao, Jun; Xu, Jia-Ying; Zhang, Weiguo; Han, Shufen; Qin, Li-Qiang

    2015-02-01

    Previous studies suggested that dietary fiber intake may have a lowing effect on circulating C-reactive protein (CRP) level, a sensitive marker of inflammation, in overweight/obese adults with inconsistent results. A literature search was performed in April 2014 for related randomized controlled trials (RCTs) and meta-analysis was conducted. Meta-analysis including 14 RCTs showed that intervention with dietary fiber or fiber-rich food, compared with control, produced a slight, but significant reduction of 0.37 mg/L (95% CI -0.74, 0) in circulating CRP level among this population. Subgroup analyses showed that such a significant reduction was only observed after combining studies where the total fiber intake was 8 g/d higher in the intervention group than in the control group. No obvious heterogeneity and publication bias were found in the meta-analysis. In conclusion, this meta-analysis provides evidence that dietary fiber or food naturally rich in fiber has beneficial effects on circulating CRP level in overweight/obese adults.

  9. Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: A pilot case-control study.

    Science.gov (United States)

    Kaneko, Chihiro; Kobayashi, Tetsuo; Ito, Satoshi; Sugita, Noriko; Murasawa, Akira; Nakazono, Kiyoshi; Yoshie, Hiromasa

    2018-01-01

    An interrelationship between rheumatoid arthritis (RA) and periodontitis has been suggested due to their common pathogenic mechanisms. Protein carbamylation and neutrophil extracellular traps (NETs) formation have been shown to be related to autoimmune conditions, including RA, but their association with periodontitis has not been elucidated. Therefore, we assessed whether or not circulating levels of carbamylated protein (CarP) and NETs are associated with periodontitis severity and influenced by periodontal treatment. We conducted a retrospective case-control study that included 40 patients with RA and periodontitis, 30 patients with periodontitis, and 43 systemically and periodontally healthy controls to assess the circulating levels of CarP and NETs and rheumatologic and periodontal conditions. The same assessments were also performed in 22 patients with RA and periodontitis after 2 months of periodontal treatment, including oral hygiene instruction and full-mouth supragingival scaling. Patients with RA and periodontitis showed significantly higher serum levels of CarP and NETs than the control group (P = 0.04 and P periodontitis. Multiple logistic regression analyses also revealed significantly positive associations between the serum levels of CarP and NETs and moderate to severe periodontitis (P = 0.03 and P = 0.001, respectively). Furthermore, periodontal treatment significantly decreased the serum levels of CarP and NETs in patients with RA and periodontitis (P = 0.03 and P = 0.02). The circulating levels of CarP and NETs are associated with periodontitis severity and influenced by periodontal treatment in patients with RA.

  10. Controlling thermal properties of dense gas fluidized beds for concentrated solar power by internal and external solids circulation

    Science.gov (United States)

    Ammendola, Paola; Bareschino, Piero; Chirone, Riccardo; Salatino, Piero; Solimene, Roberto

    2017-06-01

    Fluidization technology displays a long record of success stories, mostly related to applications to thermal and thermochemical processes, which are fostering extension to novel and relatively unexplored fields. Application of fluidized beds to collection and thermal storage of solar radiation in Concentrated Solar Power (CSP) is one of the most promising, a field which poses challenging issues and great opportunities to fluidization scientists and technologists. The potential of this growing field calls for reconsideration of some of the typical design and operation guidelines and criteria, with the goal of exploiting the inherently good thermal performances of gas-fluidized beds at their best. "Creative" and non-conventional design and operation of fluidized beds, like those based on internal and external solids circulation, may be beneficial to the enhancement of thermal diffusivity and surface-to-bed heat transfer, improving the potential for application in the very demanding context of CSP with thermal energy storage. This paper investigated: i) a fluidized bed configuration with an uneven distribution of the fluidizing gas to promote vortices in the scale of bed height (internal solids circulation); ii) a dual fluidized bed configuration characterized by an external solids circulation achieved by the operation of a riser and a bubbling fluidized bed. CFD simulations showed the hydrodynamics conditions under which the internal solids circulation was established. The hydrodynamic characterization of the external solids circulation was achieved by an experimental study carried out with different cold models. The dual fluidized bed system was optimized in terms of operating conditions and geometrical features of the connections between two fluidized beds.

  11. Small causes, big effects. For environment and sales: Check of thermostat valves in the internet; Kleine Ursache, grosse Wirkung. Zugunsten Umwelt und Umsatz: Thermostatventil-Check jetzt im Internet

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2008-04-15

    Fifty percent of all installed thermostat valves are assumed to be lacking in energy efficiency, according to the ''Optimus'' research report. Industry has reacted to this by developing a ThermostatCheck, which can be accessed in the internet by builder-owners and fitters. (orig.)

  12. The Effect of Omega-3 on Circulating Adiponectin in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    Science.gov (United States)

    Bahreini, Mehdi; Ramezani, Amir-Hossein; Shishehbor, Farideh; Mansoori, Anahita

    2018-01-04

    Whether consumption of omega-3 affects circulating adiponectin has not been established. The objective of this study was to evaluate the effect of omega-3 (food or supplement) on circulating adiponectin in patients with type 2 diabetes through a systematic review of meta-analyses of randomized controlled trials. PubMed, Scopus and Web of Science were searched for relevant studies through May 2016. Two researchers screened and abstracted the literature independently. Pooled estimates were obtained using the random-effects models. Overall, omega-3 increased adiponectin by 0.57 µg/mL (95% confidence interval [CI] 0.15 to 1.31; p=0.01, I-square=74.2% p for heterogeneity omega-3 for more than 8 weeks. This systematic review and meta-analysis of randomized, placebo-controlled clinical trials suggests that omega-3 in patients with type 2 diabetes increases circulating adiponectin. These findings support the potentially beneficial effects of dietary omega-3 in patients with type 2 diabetes on pathways related to adiponectin metabolism. Copyright © 2017 Diabetes Canada. Published by Elsevier Inc. All rights reserved.

  13. Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression

    DEFF Research Database (Denmark)

    Nielsen, Lotte B.; Wang, Cheng; Sorensen, Kaspar

    2012-01-01

    This study aims to identify key miRNAs in circulation, which predict ongoing beta-cell destruction and regeneration in children with newly diagnosed Type 1 Diabetes (T1D). We compared expression level of sera miRNAs from new onset T1D children and age-matched healthy controls and related the miRN...

  14. VanderLaan Circulant Type Matrices

    Directory of Open Access Journals (Sweden)

    Hongyan Pan

    2015-01-01

    Full Text Available Circulant matrices have become a satisfactory tools in control methods for modern complex systems. In the paper, VanderLaan circulant type matrices are presented, which include VanderLaan circulant, left circulant, and g-circulant matrices. The nonsingularity of these special matrices is discussed by the surprising properties of VanderLaan numbers. The exact determinants of VanderLaan circulant type matrices are given by structuring transformation matrices, determinants of well-known tridiagonal matrices, and tridiagonal-like matrices. The explicit inverse matrices of these special matrices are obtained by structuring transformation matrices, inverses of known tridiagonal matrices, and quasi-tridiagonal matrices. Three kinds of norms and lower bound for the spread of VanderLaan circulant and left circulant matrix are given separately. And we gain the spectral norm of VanderLaan g-circulant matrix.

  15. Methods for a Smart Thermostat to Estimate the Characteristics of a House Based on Sensor Data with Varying Extent of Completeness

    NARCIS (Netherlands)

    van der Ham, Wim; Klein, Michel; Tabatabaei, Seyed Amin; Thilakarathne, Dilhan; Treur, Jan

    Smart thermostats can play an important role in achieving more economic energy usage in domestic situations. This paper focuses on the energy used for natural gas-based heating, and monitoring of gas usages versus indoor and outdoor temperatures over time. Two methods are presented that enable the

  16. Meteorologic, oceanographic, and geomorphic controls on circulation and residence time in a coral reef-lined embayment: Faga'alu Bay, American Samoa

    Science.gov (United States)

    Storlazzi, C. D.; Cheriton, O. M.; Messina, A. M.; Biggs, T. W.

    2018-06-01

    Water circulation over coral reefs can determine the degree to which reef organisms are exposed to the overlying waters, so understanding circulation is necessary to interpret spatial patterns in coral health. Because coral reefs often have high geomorphic complexity, circulation patterns and the duration of exposure, or "local residence time" of a water parcel, can vary substantially over small distances. Different meteorologic and oceanographic forcings can further alter residence time patterns over reefs. Here, spatially dense Lagrangian surface current drifters and Eulerian current meters were used to characterize circulation patterns and resulting residence times over different regions of the reefs in Faga'alu Bay, American Samoa, during three distinct forcing periods: calm, strong winds, and large waves. Residence times varied among different geomorphic zones of the reef and were reflected in the spatially varying health of the corals across the embayment. The relatively healthy, seaward fringing reef consistently had the shortest residence times, as it was continually flushed by wave breaking at the reef crest, whereas the degraded, sheltered, leeward fringing reef consistently had the longest residence times, suggesting this area is more exposed to land-based sources of pollution. Strong wind forcing resulted in the longest residence times by pinning the water in the bay, whereas large wave forcing flushed the bay and resulted in the shortest residence times. The effect of these different forcings on residence times was fairly consistent across all reef geomorphic zones, with the shift from wind to wave forcing shortening mean residence times by approximately 50%. Although ecologically significant to the coral organisms in the nearshore reef zones, these shortened residence times were still 2-3 times longer than those associated with the seaward fringing reef across all forcing conditions, demonstrating how the geomorphology of a reef environment sets a

  17. Human rotavirus vaccine Rotarix™ provides protection against diverse circulating rotavirus strains in African infants: a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Steele Andrew

    2012-09-01

    Full Text Available Abstract Background Rotaviruses are the most important cause of severe acute gastroenteritis worldwide in children Rotarix™ significantly reduced severe rotavirus gastroenteritis episodes in a Phase III clinical trial conducted in infants in South Africa and Malawi. This paper examines rotavirus vaccine efficacy in preventing severe rotavirus gastroenteritis, during infancy, caused by the various G and P rotavirus types encountered during the first rotavirus-season. Methods Healthy infants aged 5–10 weeks were enrolled and randomized into three groups to receive either two (10 and 14 weeks or three doses of Rotarix™ (together forming the pooled Rotarix™ group or three doses of placebo at a 6,10,14-week schedule. Weekly home visits were conducted to identify gastroenteritis episodes. Rotaviruses were detected by ELISA and genotyped by RT-PCR and nucleotide sequencing. The percentage of infants with severe rotavirus gastroenteritis caused by the circulating G and P types from 2 weeks post-last dose until one year of age and the corresponding vaccine efficacy was calculated with 95% CI. Results Overall, 4939 infants were vaccinated and 4417 (pooled Rotarix™ = 2974; placebo = 1443 were included in the per protocol efficacy cohort. G1 wild-type was detected in 23 (1.6% severe rotavirus gastroenteritis episodes from the placebo group. This was followed in order of detection by G12 (15 [1%] in placebo and G8 types (15 [1%] in placebo. Vaccine efficacy against G1 wild-type, G12 and G8 types were 64.1% (95% CI: 29.9%; 82%, 51.5% (95% CI:-6.5%; 77.9% and 64.4% (95% CI: 17.1%; 85.2%, respectively. Genotype P[8] was the predominant circulating P type and was detected in 38 (2.6% severe rotavirus gastroenteritis cases in placebo group. The remaining circulating P types comprised of P[4] (20 [1.4%] in placebo and P[6] (13 [0.9%] in placebo. Vaccine efficacy against P[8] was 59.1% (95% CI: 32.8%; 75.3%, P[4] was 70.9% (95% CI: 37.5%; 87

  18. Human rotavirus vaccine Rotarix™ provides protection against diverse circulating rotavirus strains in African infants: a randomized controlled trial.

    Science.gov (United States)

    Steele, Andrew Duncan; Neuzil, Kathleen M; Cunliffe, Nigel A; Madhi, Shabir A; Bos, Pieter; Ngwira, Bagrey; Witte, Desiree; Todd, Stacy; Louw, Cheryl; Kirsten, Mari; Aspinall, Sanet; Van Doorn, Leen Jan; Bouckenooghe, Alain; Suryakiran, Pemmaraju V; Han, Htay Htay

    2012-09-13

    Rotaviruses are the most important cause of severe acute gastroenteritis worldwide in children rotavirus vaccine Rotarix™ significantly reduced severe rotavirus gastroenteritis episodes in a Phase III clinical trial conducted in infants in South Africa and Malawi. This paper examines rotavirus vaccine efficacy in preventing severe rotavirus gastroenteritis, during infancy, caused by the various G and P rotavirus types encountered during the first rotavirus-season. Healthy infants aged 5-10 weeks were enrolled and randomized into three groups to receive either two (10 and 14 weeks) or three doses of Rotarix™ (together forming the pooled Rotarix™ group) or three doses of placebo at a 6,10,14-week schedule. Weekly home visits were conducted to identify gastroenteritis episodes. Rotaviruses were detected by ELISA and genotyped by RT-PCR and nucleotide sequencing. The percentage of infants with severe rotavirus gastroenteritis caused by the circulating G and P types from 2 weeks post-last dose until one year of age and the corresponding vaccine efficacy was calculated with 95% CI. Overall, 4939 infants were vaccinated and 4417 (pooled Rotarix™ = 2974; placebo = 1443) were included in the per protocol efficacy cohort. G1 wild-type was detected in 23 (1.6%) severe rotavirus gastroenteritis episodes from the placebo group. This was followed in order of detection by G12 (15 [1%] in placebo) and G8 types (15 [1%] in placebo). Vaccine efficacy against G1 wild-type, G12 and G8 types were 64.1% (95% CI: 29.9%; 82%), 51.5% (95% CI:-6.5%; 77.9%) and 64.4% (95% CI: 17.1%; 85.2%), respectively. Genotype P[8] was the predominant circulating P type and was detected in 38 (2.6%) severe rotavirus gastroenteritis cases in placebo group. The remaining circulating P types comprised of P[4] (20 [1.4%] in placebo) and P[6] (13 [0.9%] in placebo). Vaccine efficacy against P[8] was 59.1% (95% CI: 32.8%; 75.3%), P[4] was 70.9% (95% CI: 37.5%; 87.0%) and P[6] was 55.2% (95% CI: -6

  19. Effects of chronic acetazolamide administration on gas exchange and acid-base control in pulmonary circulation in exercising horses.

    Science.gov (United States)

    Vengust, M; Stämpfli, H; De Moraes, A N; Teixeiro-Neto, F; Viel, L; Heigenhauser, G

    2010-11-01

    Carbonic anhydrase (CA) catalyses the hydration/dehydration reaction of CO(2) and increases the rate of Cl(-) and HCO(3)(-) exchange between the erythrocytes and plasma. Therefore, chronic inhibition of CA has a potential to attenuate CO(2) output and induce greater metabolic and respiratory acidosis in exercising horses. To determine the effects of Carbonic anhydrase inhibition on CO(2) output and ionic exchange between erythrocytes and plasma and their influence on acid-base balance in the pulmonary circulation (across the lung) in exercising horses with and without CA inhibition. Six horses were exercised to exhaustion on a treadmill without (Con) and with CA inhibition (AczTr). CA inhibition was achieved with administration of acetazolamide (10 mg/kg bwt t.i.d. for 3 days and 30 mg/kg bwt before exercise). Arterial, mixed venous blood and CO(2) output were sampled at rest and during exercise. An integrated physicochemical systems approach was used to describe acid base changes. AczTr decreased the duration of exercise by 45% (P changes across the lung with exception of lactate. CO(2) and chloride changes in erythrocytes across the lung seem to be the major contributors to acid-base and ions balance in pulmonary circulation in exercising horses. © 2010 EVJ Ltd.

  20. Co-circulation of two extremely divergent serotype SAT 2 lineages in Kenya highlights challenges to foot-and-mouth disease control

    DEFF Research Database (Denmark)

    Sangula, Abraham; Belsham, Graham; Muwanika, Vincent

    2010-01-01

    Amongst the SAT serotypes of foot-and-mouth disease virus (FMDV), the SAT 2 serotype is the most widely distributed throughout sub-Saharan Africa. Kenyan serotype SAT 2 viruses have been reported to display the highest genetic diversity for the serotype globally. This complicates diagnosis...... and control, and it is essential that patterns of virus circulation are known in order to overcome these difficulties. This study was undertaken to establish patterns of evolution of FMDV serotype SAT 2 in Kenya using complete VP1 coding sequences in a dataset of 65 sequences from Africa, collected over...

  1. Circulating Betatrophin Correlates with Triglycerides and Postprandial Glucose among Different Glucose Tolerance Statuses--A Case-Control Study.

    Science.gov (United States)

    Gao, Ting; Jin, Kairui; Chen, Peihong; Jin, Hua; Yang, Lili; Xie, Xinmiao; Yang, Meili; Hu, Cheng; Yu, Xuemei

    2015-01-01

    Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and in subjects with both impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) and investigated the relationship between serum betatrophin and other clinical parameters in these patients with different glucose tolerance statuses. A total of 460 permanent residents of the Fengxian District, aged 40-60 years, were enrolled. Based on the results of a 75 g oral glucose tolerance test, we selected newly diagnosed T2DM (n = 50) patients and subjects with IGT (n = 51) and NGT (n = 50) according to their age, gender and body mass index (18-28 kg/m2). Anthropometric parameters, glycosylated haemoglobin, blood lipids and fasting insulin were measured. Serum betatrophin concentrations were determined via ELISA. Serum betatrophin levels in T2DM patients were increased significantly compared with IGT and NGT groups, and decreased in subjects with better islet beta cell function. Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass index in all subjects. Multiple regression analysis showed that 2-hour postprandial glucose was independently associated with serum betatrophin significantly. Circulating betatrophin is increased in newly-diagnosed T2DM patients and positively correlated with the triglycerides and postprandial glucose levels. The results suggest that betatrophin may participate in glucose and triglycerides metabolism.

  2. Circulating Betatrophin Correlates with Triglycerides and Postprandial Glucose among Different Glucose Tolerance Statuses—A Case-Control Study

    Science.gov (United States)

    Chen, Peihong; Jin, Hua; Yang, Lili; Xie, Xinmiao; Yang, Meili; Hu, Cheng; Yu, Xuemei

    2015-01-01

    Purpose Previous researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and in subjects with both impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) and investigated the relationship between serum betatrophin and other clinical parameters in these patients with different glucose tolerance statuses. Methods A total of 460 permanent residents of the Fengxian District, aged 40–60 years, were enrolled. Based on the results of a 75 g oral glucose tolerance test, we selected newly diagnosed T2DM (n = 50) patients and subjects with IGT (n = 51) and NGT (n = 50) according to their age, gender and body mass index (18–28 kg/m2). Anthropometric parameters, glycosylated haemoglobin, blood lipids and fasting insulin were measured. Serum betatrophin concentrations were determined via ELISA. Results Serum betatrophin levels in T2DM patients were increased significantly compared with IGT and NGT groups, and decreased in subjects with better islet beta cell function. Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass index in all subjects. Multiple regression analysis showed that 2-hour postprandial glucose was independently associated with serum betatrophin significantly. Conclusions Circulating betatrophin is increased in newly-diagnosed T2DM patients and positively correlated with the triglycerides and postprandial glucose levels. The results suggest that betatrophin may participate in glucose and triglycerides metabolism. PMID:26247824

  3. Energy conservation by means of reduced circulation. On/off versus frequency control; Energiebesparing door verminderde circulatie. Aan/uit- versus Frequentieregeling

    Energy Technology Data Exchange (ETDEWEB)

    Wildschut, J.; Gude, H. [Praktijkonderzoek Plant en Omgeving PPO, Bloembollen, Boomkwekerij en Fruit, Lisse (Netherlands); Kreuk, N.; Kok, M. [DLV Plant, Wageningen (Netherlands)

    2005-11-15

    The main purpose of this demo was to show that during the storage season for tulip bulbs, relatively much energy and money can be saved by circulating bulbs well below the general standard of 500 m{sup 3} air/hour/m{sup 3}. To this end, two storage walls were placed in a cold store. In one of the stacked crates the circulation amount was reduced by means of a frequency control, whereas in the other one an on/off control was used. The energy meters were read three times per week for both set-ups [Dutch] Hoofddoel van deze demo was te demonstreren dat er gedurende het bewaarseizoen voor tulpenbollen relatief veel energie en geld bespaard kan worden door ruim onder de algemene norm van 500 m{sup 3} lucht/uur/m{sup 3} bollen te circuleren. Hiertoe zijn in een bewaarcel twee bewaarwanden opgesteld. In de ene kistenstapeling is de circulatiehoeveelheid teruggebracht d.m.v. een frequentieregeling, in de andere d.m.v. van een aan/uit regeling. De energiemeterstanden werden voor elke opstelling 3 maal per week bijgehouden.

  4. Premenopausal Levels of Circulating Insulin-Like Growth Factor I and the Risk of Post-Menopausal Breast Cancer: A Population-Based, Nested Case-Control Study

    National Research Council Canada - National Science Library

    Newschaffer, Craig

    2002-01-01

    High levels of circulating IGF-l may be a risk factor for breast cancer. Only one population-based epidemiologic study of IGF-l and breast cancer measured circulating IGF-l in serum drawn prior to diagnosis...

  5. Vildagliptin, but not glibenclamide, increases circulating endothelial progenitor cell number: a 12-month randomized controlled trial in patients with type 2 diabetes.

    Science.gov (United States)

    Dei Cas, Alessandra; Spigoni, Valentina; Cito, Monia; Aldigeri, Raffaella; Ridolfi, Valentina; Marchesi, Elisabetta; Marina, Michela; Derlindati, Eleonora; Aloe, Rosalia; Bonadonna, Riccardo C; Zavaroni, Ivana

    2017-02-23

    Fewer circulating endothelial progenitor cells (EPCs) and increased plasma (C-term) stromal cell-derived factor 1α (SDF-1α), a substrate of DPP-4, are biomarkers, and perhaps mediators, of cardiovascular risk and mortality. Short-term/acute treatment with DPP-4 inhibitors improve EPC bioavailability; however, long-term effects of DPP-4i on EPCs bioavailability/plasma (C-term) SDF-1α are unknown. Randomized (2:1) open-label trial to compare the effects of vildagliptin (V) (100 mg/day) vs glibenclamide (G) (2.5 mg bid to a maximal dose of 5 mg bid) on circulating EPC levels at 4 and 12 months of treatment in 64 patients with type 2 diabetes in metformin failure. At baseline, and after 4 and 12 months, main clinical/biohumoral parameters, inflammatory biomarkers, concomitant therapies, EPC number (CD34 + /CD133 + /KDR + /10 6 cytometric events) and plasma (C-term) SDF-1α (R&D system) were assessed. Baseline characteristics were comparable in the two groups. V and G similarly and significantly (p < 0.0001) improved glucose control. At 12 months, V significantly increased EPC number (p < 0.05) and significantly reduced (C-term) SDF-1α plasma levels (p < 0.01) compared to G, with no differences in inflammatory biomarkers. V exerts a long-term favorable effect on EPC and (C-term) SDF-1α levels at glucose equipoise, thereby implying a putative beneficial effect on vascular integrity. Trial registration Clinical Trials number: NCT01822548; name: Effect of Vildagliptin vs. Glibenclamide on Circulating Endothelial Progenitor Cell Number Type 2 Diabetes. Registered 28 March, 2013.

  6. Advances on development of suction and temperature controlled oedometer cell

    International Nuclear Information System (INIS)

    Ye Weimin; Zhang Yawei; Chen Bao; Wang Min

    2010-01-01

    Oedometer cells for unsaturated soils can be classified into two types, that is, conventional unsaturated oedometer cells (high-suction unsaturated oedometer cell, high-suction and high-pressure unsaturated oedometer cell) and temperature controlled unsaturated oedometer cells. Among them, the osmotic, vapor equilibrium and axis translation techniques are often employed for suction control. The thermostat bath method and thermostatically controlled heater method are commonly used for temperature control. The lever loading system, hydraulic loading system and air pressure loading system are commonly means used for vertical pressure. Combination of osmotic (or axis translation) technique with vapor equilibrium method employed for the full range suction control, thermostatically liquid temperature control method, and the hydraulic loading system, could be used for suction, temperature and loading control in the design for unsaturated oedometer cells in the future, which can be used for study of buffer/backfill materials under high-temperature, high pressure and full range suction conditions. (authors)

  7. Large-scale Circulation Control of the Occurrence of Low-level Turbulence at Hong Kong International Airport

    Science.gov (United States)

    Leung, Marco Y. T.; Zhou, Wen; Shun, Chi-Ming; Chan, Pak-Wai

    2018-04-01

    This study identifies the atmospheric circulation features that are favorable for the occurrence of low-level turbulence at Hong Kong International Airport [below 1600 feet (around 500 m)]. By using LIDAR data at the airport, turbulence and nonturbulence cases are selected. It is found that the occurrence of turbulence is significantly related to the strength of the southerly wind at 850 hPa over the South China coast. On the other hand, the east-west wind at this height demonstrates a weak relation to the occurrence. This suggests that turbulence is generated by flow passing Lantau Island from the south. The southerly wind also transports moisture from the South China Sea to Hong Kong, reducing local stability. This is favorable for the development of strong turbulence. It is also noted that the strong southerly wind during the occurrence of low-level turbulence is contributed by an anomalous zonal gradient of geopotential in the lower troposphere over the South China Sea. This gradient is caused by the combination of variations at different timescales. These are the passage of synoptic extratropical cyclones and anticyclones and the intraseasonal variation in the western North Pacific subtropical high. The seasonal variation in geopotential east of the Tibetan Plateau leads to a seasonal change in meridional wind, by which the frequency of low-level turbulence is maximized in spring and minimized in autumn.

  8. Effect of dipeptidyl peptidase-4 inhibitors on circulating tumor necrosis factor-α concentrations: A systematic review and meta-analysis of controlled trials.

    Science.gov (United States)

    Atkin, Stephen L; Katsiki, Niki; Banach, Maciej; Mikhailidis, Dimitri P; Pirro, Matteo; Sahebkar, Amirhossein

    2017-09-01

    Dipeptidyl peptidase-4 (DPP-4) inhibitors improve glycemic control in patients with type 2 diabetes mellitus. There are also reports of an effect of these drugs in reducing inflammation through inhibition of tumor necrosis factor-α (TNF-α) that is an important mediator for several inflammatory processes. The present systematic review and meta-analysis were performed to evaluate the effect of DPP-4 inhibitors on circulating TNF-α levels in T2DM patients. A systematic review and a meta-analysis were undertaken on all controlled trials of DPP-4 inhibitors that included measurement of TNF-α. The search included PubMed-Medline, Scopus, ISI Web of Knowledge and Google Scholar databases. Quantitative data synthesis was performed using a random-effects model, with standardized mean difference (SMD) and 95% confidence interval (CI) as summary statistics. Meta-regression and leave-one-out sensitivity analysis were performed to assess the modifiers of treatment response. Eight eligible articles (6 with sitagliptin and 2 with vildagliptin) comprising 9 treatment arms were selected for this meta-analysis. Meta-analysis suggested a significant reduction of circulating TNF-α concentrations following treatment with DPP-4 inhibitors (SMD: -1.84, 95% CI: -2.88, -0.80, p=0.001). The effect size was robust in the sensitivity analysis and not mainly driven by a single study. A subgroup analysis did not suggest any significant difference between the TNF-α-lowering activity of sitagliptin (SMD: -1.49, 95% CI: -2.89, -0.10) and vildagliptin (SMD: -2.80, 95% CI: -4.98, -0.61) (p=0.326). This meta-analysis of the 8 available controlled trials showed that DPP-4 inhibition in patients with type 2 diabetes mellitus was associated with significant reductions in plasma TNF-α levels with no apparent difference between sitagliptin and vildagliptin. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Design and Implementation of a Room Thermostat Using an Agent-based Approach

    NARCIS (Netherlands)

    van Breemen, A.J.N.; de Vries, Theodorus J.A.

    2001-01-01

    A large number of control systems operate in the real-world and are expected to deal with the range of changing conditions of the physical process that is being controlled. It may be a laborious and difficult task to design one controller that fits all operating conditions. In reality, several

  10. Seasonal overturning circulation in the Red Sea: 2. Winter circulation

    Science.gov (United States)

    Yao, Fengchao; Hoteit, Ibrahim; Pratt, Larry J.; Bower, Amy S.; Köhl, Armin; Gopalakrishnan, Ganesh; Rivas, David

    2014-04-01

    The shallow winter overturning circulation in the Red Sea is studied using a 50 year high-resolution MITgcm (MIT general circulation model) simulation with realistic atmospheric forcing. The overturning circulation for a typical year, represented by 1980, and the climatological mean are analyzed using model output to delineate the three-dimensional structure and to investigate the underlying dynamical mechanisms. The horizontal model circulation in the winter of 1980 is dominated by energetic eddies. The climatological model mean results suggest that the surface inflow intensifies in a western boundary current in the southern Red Sea that switches to an eastern boundary current north of 24°N. The overturning is accomplished through a cyclonic recirculation and a cross-basin overturning circulation in the northern Red Sea, with major sinking occurring along a narrow band of width about 20 km along the eastern boundary and weaker upwelling along the western boundary. The northward pressure gradient force, strong vertical mixing, and horizontal mixing near the boundary are the essential dynamical components in the model's winter overturning circulation. The simulated water exchange is not hydraulically controlled in the Strait of Bab el Mandeb; instead, the exchange is limited by bottom and lateral boundary friction and, to a lesser extent, by interfacial friction due to the vertical viscosity at the interface between the inflow and the outflow.

  11. Circulating SFRP5 levels are elevated in drug-naïve recently diagnosed type 2 diabetic patients as compared with prediabetic subjects and controls.

    Science.gov (United States)

    Canivell, Silvia; Rebuffat, Sandra; Ruano, Elena G; Kostov, Belchin; Sisó-Almirall, Antoni; Novials, Anna; Ceriello, Antonio; Gomis, Ramon

    2015-02-01

    Secreted frizzled-related protein 5 (SFRP5) has been linked to obesity. Results are conflicting regarding its association with type 2 diabetes (T2D) in humans. We aimed to investigate circulating SFRP5 in prediabetes and T2D and its potential association with parameters of insulin resistance and beta-cell function. We studied 70 drug-naïve T2D patients, 70 prediabetic subjects and 70 controls. All subjects were body mass index matched to the T2D patients and overweight or obese. SFRP5, hormones and cytokines levels were measured by ELISA. Serum SFRP5 levels were elevated in T2D patients as compared with prediabetic subjects (median 15.6, interquartile range [9-24.5] ng/mL vs 9.8 [5-14.2] ng/mL, p prediabetic subjects and controls (9.8 [5-14.2] ng/mL vs 10.4 [6.7-16.6] ng/mL, p = 0.472, respectively). After adjusting for potential confounders (age, gender, body mass index, triglycerides, high-density lipoprotein cholesterol and blood pressure), T2D was still associated with higher values of SFRP5 as compared with prediabetes in multinomial logistic regression analysis (fully adjusted odds ratio 3.50, 95% confidence interval 1.40-8.79, p = 0.008). The association was more subtle when comparing T2D with normal glucose tolerance state (fully adjusted odds ratio 2.18, 95% confidence interval 0.91-5.21, p = 0.078). Circulating SFRP5 levels were independently associated with T2D as compared with prediabetes and normal glucose tolerance state. Copyright © 2014 John Wiley & Sons, Ltd.

  12. Portable Microplate Analyzer with a Thermostatic Chamber Based on a Smartphone for On-site Rapid Detection.

    Science.gov (United States)

    Wan, Zijian; Zhong, Longjie; Pan, Yuxiang; Li, Hongbo; Zou, Quchao; Su, Kaiqi; Wang, Ping

    2017-01-01

    A microplate method provides an efficient way to use modern detection technology. However, there are some difficulties concerning on-site detection, such as being non-portable and time-consuming. In this work, a novel portable microplate analyzer with a thermostatic chamber based on a smartphone was designed for rapid on-site detection. An analyzer with a wide-angle lens and an optical filter provides a proper environment for the microplate. A smartphone app-iPlate Monitor was used for RGB analyze of image. After a consistency experiment with a microtiter plate reader (MTPR), the normalized calibration curves were y = 0.7276x + 0.0243 (R 2 = 0.9906) and y = 0.3207x + 0.0094 (R 2 = 0.9917) with a BCA protein kit as well as y = 0.182x + 0.0134 (R 2 = 0.994) and y = 0.0674x + 0.0003 (R 2 = 0.9988) with a glucose kit. The times for obtaining the detection requirement were 15 and 10 min for the BCA protein kit and the glucose kit at 37°C; in contrast, it required more than 30 and 20 min at ambient temperature. Meanwhile, it also showed good repeatability for detections.

  13. Lixiviation of heavy metals of hazardous industrial wastes by means of thermostatized columns and design of a pilot plant

    International Nuclear Information System (INIS)

    Vite T, J.; Leon, C.C. de; Vite T, M.; Soto T, J.L.

    2006-01-01

    The purpose of this work was to evaluate the efficiency of lixiviation of heavy metals, using thermostatized columns and hazardous industrial residual wastes: those by the volume with which are generated and its high toxicity, its represent a great problem for it treatment and disposition, in this work a diagram of a pilot plant for extraction of heavy metals is included. The process and equipment were patented in United States and in Mexico. For the development of this study four thermostated columns were used that were coupled. The waste were finely milled and suspended in an aqueous pulp adding of 10 - 40gL -1 of mineral acid or sodium hydroxide until reaching an interval of pH of 2,5,7 and 10. Its were used of 4-10 gL -1 of a reducer agent and of 0.3-1.5 g of a surfactant agent. In some cases with this method was possible to remove until 100% of heavy metals. It was used Plasma Emission Spectroscopy to determine the concentrations of the cations in the lixiviation liquors. For studying the metallic alloys the X-ray diffraction technique was used. (Author)

  14. Can we determine what controls the spatio-temporal distribution of d-excess and 17O-excess in precipitation using the LMDZ general circulation model?

    Directory of Open Access Journals (Sweden)

    C. Risi

    2013-09-01

    Full Text Available Combined measurements of the H218O and HDO isotopic ratios in precipitation, leading to second-order parameter D-excess, have provided additional constraints on past climates compared to the H218O isotopic ratio alone. More recently, measurements of H217O have led to another second-order parameter: 17O-excess. Recent studies suggest that 17O-excess in polar ice may provide information on evaporative conditions at the moisture source. However, the processes controlling the spatio-temporal distribution of 17O-excess are still far from being fully understood. We use the isotopic general circulation model (GCM LMDZ to better understand what controls d-excess and 17O-excess in precipitation at present-day (PD and during the last glacial maximum (LGM. The simulation of D-excess and 17O-excess is evaluated against measurements in meteoric water, water vapor and polar ice cores. A set of sensitivity tests and diagnostics are used to quantify the relative effects of evaporative conditions (sea surface temperature and relative humidity, Rayleigh distillation, mixing between vapors from different origins, precipitation re-evaporation and supersaturation during condensation at low temperature. In LMDZ, simulations suggest that in the tropics convective processes and rain re-evaporation are important controls on precipitation D-excess and 17O-excess. In higher latitudes, the effect of distillation, mixing between vapors from different origins and supersaturation are the most important controls. For example, the lower d-excess and 17O-excess at LGM simulated at LGM are mainly due to the supersaturation effect. The effect of supersaturation is however very sensitive to a parameter whose tuning would require more measurements and laboratory experiments. Evaporative conditions had previously been suggested to be key controlling factors of d-excess and 17O-excess, but LMDZ underestimates their role. More generally, some shortcomings in the simulation of 17O

  15. LES of High-Reynolds-Number Coanda Flow Separating from a Rounded Trailing Edge of a Circulation Control Airfoil

    Science.gov (United States)

    Nichino, Takafumi; Hahn, Seonghyeon; Shariff, Karim

    2010-01-01

    This slide presentation reviews the Large Eddy Simulation of a high reynolds number Coanda flow that is separated from a round trailing edge of a ciruclation control airfoil. The objectives of the study are: (1) To investigate detailed physics (flow structures and statistics) of the fully turbulent Coanda jet applied to a CC airfoil, by using LES (2) To compare LES and RANS results to figure out how to improve the performance of existing RANS models for this type of flow.

  16. Effect of thermostat and window opening occupant behavior models on energy use in homes

    DEFF Research Database (Denmark)

    D'Oca, Simona; Fabi, Valentina; Corgnati, Stefano P.

    2014-01-01

    Existing dynamic energy simulation tools exceed the static dimension of the simplified methods through a better and more accurate prediction of energy use; however, their ability to predict real energy consumption is undermined by a weak representation of human interactions with the control of th...

  17. Energy conservation in refrigerating machines by combining of thermo-static expansion valve and interior heat transfer material; Energieeinsparung in Kaelteanlagen durch Kombination von thermostatischem Expansionsventil und innerem Waermeuebertrager

    Energy Technology Data Exchange (ETDEWEB)

    Tambovtsev, Alexander

    2007-12-15

    The invention of the refrigerating machine enables to generate cold energy in any needed amount and at any desired temperature. However, cold energy generation requires driving energy. The target of this dissertation is to reduce the energy consumption of refrigerating plants considerably by means of an intelligent combination of the thermo-static expansion valve and the interior heat transfer medium. This combination should not deteriorate the reliability nor incur additional costs. Until today the two known components thermo-static expansion valve and interior heat transfer medium are considered as incompatible, because the simple connection of both components leads to an unstable control behaviour. After a detailed analysis of the causes for this instability the hypothesis is made, a stable working area can be found by means of a deliberate ''deterioration'' of the internal heat transfer medium. This ''deterioration'' can be e.g. a bypass of a part of the high-pressure flow or a parallel flow arrangement of the flows in the heat transfer medium. This hypothesis was primarily proved by experiments, but also by simulation calculations. A test stand was set-up for this purpose, which was used to test various configurations and control strategies. A considerable reduction of the energy consumption compared to conventional arrangements was achieved. (orig.) [German] Die Erfindung der Kaeltemaschine macht es moeglich, dass heute zu beliebiger Zeit Kaelte in benoetigter Menge und gewuenschter Temperatur erzeugt werden kann. Aber fuer die Kaelteerzeugung braucht man Antriebsenergie. Das Ziel dieser Doktorarbeit besteht darin, mit einer intelligenten Kombination von thermostatischem Expansionsventil (TEV) und innerem Waermeuebertrager (IWUe) den Energieverbrauch von Kaelteanlagen deutlich zu verringern, ohne dass dies zu einer Verschlechterung der Zuverlaessigkeit oder wesentlichen Mehrkosten fuehrt. Bis heute gelten die beiden

  18. Circulating microRNA expression pattern separates patients with anti-neutrophil cytoplasmic antibody-associated vasculitis from healthy controls

    DEFF Research Database (Denmark)

    Skoglund, C.; Carlsen, A.; Weiner, M.

    2015-01-01

    patients from healthy subjects as well as from renal transplant recipients. Loadings plots indicated similar contribution of the same miRNAs in both cohorts to the PCA. Renal engagement was important for miRNA expression but consistent correlations between estimated glomerular filtration rate and mi......Objective. Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) has an unpredictable course and better biomarkers are needed. Micro-RNAs in body fluids are protected from degradation and might be used as biomarkers for diagnosis and prognosis, here we explore the potential in AAV...... individual miRNAs were differently expressed compared to controls in both cohorts; miR-29a, -34a, -142-3p and -383 were up-regulated and miR-20a, -92a and -221 were down-regulated. Cluster analysis as well as principal component analysis (PCA) indicated that patterns of miRNA expression differentiate AAV...

  19. Piston-like plugging of fuzzy-ball workover fluids for controlling and killing lost circulation of gas wells

    Directory of Open Access Journals (Sweden)

    Jinfeng Wang

    2016-01-01

    Full Text Available During well-killing operations for the workover of low-pressure gas wells, formation pressure should be balanced so as to guarantee well control safety by preventing natural gas overflow. In this paper, a laboratory evaluation was conducted with fuzzy-ball fluids as killing fluids. The results show that, the fuzzy-ball fluid, with a density of 0.5–1.5 g/cm3 and a viscosity up to 78,50,000 mPa·s at a low shear rate, realizes controllable performance and forms piston-like plugging slugs of solid-free high structural strength on natural gas wellbore after bonding. During well workover, multiple fluid column pressures were set up by injecting fuzzy-ball fluids with different densities at various rates. Owing to high structural strength of the fluids at a low shear rate, natural gas breaks through only inside the piston-like slug and cannot flow upwards to the ground, so the pathways of natural gas in the wellbore are isolated from the ground surface. Moreover, the fluid can wholly move up and down like a piston-like plug, with the change of formation pressures or the tripping of pipe strings. Like the conventional operations, the production can be restored after the workover, so long as the fluid in wellbore is cleaned by means of gas lift. In a natural gas field in NW China, where the formation pressure coefficient dropped to 0.60–0.82, three wells were fully filled with fuzzy-ball workover fluids for 7 days and another three wells were treated with the piston-like plugs of fuzzy-ball workover fluids for only 3 days. They all presented better technical results. The technology provides a new way for low-pressure gas well workover.

  20. Seasonal overturning circulation in the Red Sea: 2. Winter circulation

    KAUST Repository

    Yao, Fengchao

    2014-04-01

    The shallow winter overturning circulation in the Red Sea is studied using a 50 year high-resolution MITgcm (MIT general circulation model) simulation with realistic atmospheric forcing. The overturning circulation for a typical year, represented by 1980, and the climatological mean are analyzed using model output to delineate the three-dimensional structure and to investigate the underlying dynamical mechanisms. The horizontal model circulation in the winter of 1980 is dominated by energetic eddies. The climatological model mean results suggest that the surface inflow intensifies in a western boundary current in the southern Red Sea that switches to an eastern boundary current north of 24N. The overturning is accomplished through a cyclonic recirculation and a cross-basin overturning circulation in the northern Red Sea, with major sinking occurring along a narrow band of width about 20 km along the eastern boundary and weaker upwelling along the western boundary. The northward pressure gradient force, strong vertical mixing, and horizontal mixing near the boundary are the essential dynamical components in the model\\'s winter overturning circulation. The simulated water exchange is not hydraulically controlled in the Strait of Bab el Mandeb; instead, the exchange is limited by bottom and lateral boundary friction and, to a lesser extent, by interfacial friction due to the vertical viscosity at the interface between the inflow and the outflow. Key Points Sinking occurs in a narrow boundary layer along the eastern boundary Surface western boundary current switches into an eastern boundary current Water exchange in the Strait of Bab el Mandeb is not hydraulically controlled © 2014. American Geophysical Union. All Rights Reserved.

  1. Process Control Logic Modification to Mitigate Transient Following Tripping of a Primary Circulating Pump for a 540 MWe PHWR Power Plant

    International Nuclear Information System (INIS)

    Contractor, Ankur D; Gaikwad, Avinash J.; Kumar, Rajesh; Chakraborty, G.; Vhora, S.F.

    2006-01-01

    The 540 MWe Indian Pressurised Heavy Water Reactor (PHWR) incorporates many new features as compared to the earlier 220 MWe PHWRs. To evaluate the new design features like Primary Heat Transport (PHT) system configuration with two loops, four Primary Circulating Pumps (PCPs) and four passes through core, addition of a Pressurizer (surge Tank) in the PHT system along with Feed/Bleed system and their safety related implications, simulation model have been developed. A reactor step-back is proposed following one PCP trip. The corresponding PCP in the healthy loop is tripped to avoid asymmetrical flow and pressure distribution in the two identical loops. In spite of such elaborate provisions, the margins from high/low PHT pressure are small following tripping of one PCP. Mathematical models for all the major components and sub-systems of the proposed 540 MWe PHWR were developed based on the conservation equations of mass, momentum, energy and equation of state. All the associated control systems are also modeled. The PHT system includes the reactor core with nuclear fuel, PCP, PHT system pressure controller with feed/bleed system and Pressurizer (Surge Tank). The secondary system includes mainly the Steam Generators (SGs), the SG level and pressure controllers, apart from the various steam cycle components. All these models are integrated together to form the Plant Transient Analysis Computer Code Dyna540. The scenario following one PCP trips leads to different states (high/low pressure in Reactor Outlet Header (ROH)) depending upon the banks in which the PCP trips. The pressurizer is connected to two ROHs on one side of the reactor. The system pressure is controlled based on average of four ROHs pressure. In the case of asymmetrical pump operation, this logic leads to a situation where individual ROH pressure goes very near the low/high PHT system pressure trip set point, even though the controlled average pressure is very close to the set pressure. The PHT high

  2. Effects of humeral intraosseous versus intravenous epinephrine on pharmacokinetics and return of spontaneous circulation in a porcine cardiac arrest model: A randomized control trial.

    Science.gov (United States)

    Johnson, Don; Garcia-Blanco, Jose; Burgert, James; Fulton, Lawrence; Kadilak, Patrick; Perry, Katherine; Burke, Jeffrey

    2015-09-01

    Cardiopulmonary Resuscitation (CPR), defibrillation, and epinephrine administration are pillars of advanced cardiac life support (ACLS). Intraosseous (IO) access is an alternative route for epinephrine administration when intravenous (IV) access is unobtainable. Previous studies indicate the pharmacokinetics of epinephrine administration via IO and IV routes differ, but it is not known if the difference influences return of spontaneous circulation (ROSC). The purpose of this prospective, experimental study was to determine the effects of humeral IO (HIO) and IV epinephrine administration during cardiac arrest on pharmacokinetics, ROSC, and odds of survival. Swine (N = 21) were randomized into 3 groups: humeral IO (HIO), peripheral IV (IV) and CPR/defibrillation control. Cardiac arrest was induced under general anesthesia. The swine remained in arrest for 2 min without intervention. Chest compressions were initiated and continued for 2 min. Epinephrine was administered and serial blood samples collected for pharmacokinetic analysis over 4 min. Defibrillation and epinephrine administration proceeded according to ACLS guidelines continuing for 20 min or until ROSC. Seven HIO swine, 4 IV swine, and no control swine had ROSC. There were no significant differences in ROSC, maximum concentration; except at 30 s, and time-to-concentration-maximum between the HIO and IV groups. Significant differences existed between the experimental groups and the control. The HIO delivers a higher concentration of epinephrine than the IV route at 30 s which may be a survival advantage. Clinicians may consider using the IO route to administer epinephrine during CA when there is no preexisting IV access or when IV access is unobtainable.

  3. TEMPERATURE DISTRIBUTION MONITORING AND ANALYSES AT DIFFERENT HEATING CONTROL PRINCIPLES

    DEFF Research Database (Denmark)

    Simone, Angela; Rode, Carsten; Olesen, Bjarne W.

    2010-01-01

    under different control strategies of the heating system (Pseudo Random Binary Sequence signal controlling all the heaters (PRBS) or thermostatic control of the heaters (THERM)). A comparison of the measured temperatures within the room, for the five series of experiments, shows a better correlation...

  4. Black Tea Increases Circulating Endothelial Progenitor Cells and Improves Flow Mediated Dilatation Counteracting Deleterious Effects from a Fat Load in Hypertensive Patients: A Randomized Controlled Study

    Science.gov (United States)

    Grassi, Davide; Draijer, Richard; Schalkwijk, Casper; Desideri, Giovambattista; D’Angeli, Anatolia; Francavilla, Sandro; Mulder, Theo; Ferri, Claudio

    2016-01-01

    (1) Background: Endothelial dysfunction predicts cardiovascular events. Circulating angiogenic cells (CACs) maintain and repair the endothelium regulating its function. Tea flavonoids reduce cardiovascular risk. We investigated the effects of black tea on the number of CACs and on flow-mediated dilation (FMD) before and after an oral fat in hypertensives; (2) Methods: In a randomized, double-blind, controlled, cross-over study, 19 patients were assigned to black tea (150 mg polyphenols) or a placebo twice a day for eight days. Measurements were obtained in a fasted state and after consuming whipping cream, and FMD was measured at baseline and after consumption of the products; (3) Results: Compared with the placebo, black tea ingestion increased functionally active CACs (36 ± 22 vs. 56 ± 21 cells per high-power field; p = 0.006) and FMD (5.0% ± 0.3% vs. 6.6% ± 0.3%, p FMD 1, 2, 3, and 4 h after consumption, with maximal response 2 h after intake (p FMD, while tea consumption counteracted FMD impairment (p < 0.0001); (4) Conclusions: We demonstrated the vascular protective properties of black tea by increasing the number of CACs and preventing endothelial dysfunction induced by acute oral fat load in hypertensive patients. Considering that tea is the most consumed beverage after water, our findings are of clinical relevance and interest. PMID:27854314

  5. Black Tea Increases Circulating Endothelial Progenitor Cells and Improves Flow Mediated Dilatation Counteracting Deleterious Effects from a Fat Load in Hypertensive Patients: A Randomized Controlled Study

    Directory of Open Access Journals (Sweden)

    Davide Grassi

    2016-11-01

    Full Text Available (1 Background: Endothelial dysfunction predicts cardiovascular events. Circulating angiogenic cells (CACs maintain and repair the endothelium regulating its function. Tea flavonoids reduce cardiovascular risk. We investigated the effects of black tea on the number of CACs and on flow-mediated dilation (FMD before and after an oral fat in hypertensives; (2 Methods: In a randomized, double-blind, controlled, cross-over study, 19 patients were assigned to black tea (150 mg polyphenols or a placebo twice a day for eight days. Measurements were obtained in a fasted state and after consuming whipping cream, and FMD was measured at baseline and after consumption of the products; (3 Results: Compared with the placebo, black tea ingestion increased functionally active CACs (36 ± 22 vs. 56 ± 21 cells per high-power field; p = 0.006 and FMD (5.0% ± 0.3% vs. 6.6% ± 0.3%, p < 0.0001. Tea further increased FMD 1, 2, 3, and 4 h after consumption, with maximal response 2 h after intake (p < 0.0001. Fat challenge decreased FMD, while tea consumption counteracted FMD impairment (p < 0.0001; (4 Conclusions: We demonstrated the vascular protective properties of black tea by increasing the number of CACs and preventing endothelial dysfunction induced by acute oral fat load in hypertensive patients. Considering that tea is the most consumed beverage after water, our findings are of clinical relevance and interest.

  6. PID temperature controller in pig nursery: improvements in performance, thermal comfort, and electricity use.

    Science.gov (United States)

    de Souza Granja Barros, Juliana; Rossi, Luiz Antonio; Sartor, Karina

    2016-08-01

    The use of smarter temperature control technologies in heating systems can optimize the use of electric power and performance of piglets. Two control technologies of a resistive heating system were assessed in a pig nursery: a PID (proportional, integral, and derivative) controller and a thermostat. The systems were evaluated regarding thermal environment, piglet performance, and use of electric power for 99 days. The heating system with PID controller improved the thermal environment conditions and was significantly (P PID-controlled heating system is more efficient in electricity use and provides better conditions for thermal comfort and animal performance than heating with thermostat.

  7. A High Frequency of HIV-Specific Circulating Follicular Helper T Cells Is Associated with Preserved Memory B Cell Responses in HIV Controllers.

    Science.gov (United States)

    Claireaux, M; Galperin, M; Benati, D; Nouël, A; Mukhopadhyay, M; Klingler, J; de Truchis, P; Zucman, D; Hendou, S; Boufassa, F; Moog, C; Lambotte, O; Chakrabarti, L A

    2018-05-08

    Follicular helper T cells (Tfh) play an essential role in the affinity maturation of the antibody response by providing help to B cells. To determine whether this CD4 + T cell subset may contribute to the spontaneous control of HIV infection, we analyzed the phenotype and function of circulating Tfh (cTfh) in patients from the ANRS CO21 CODEX cohort who naturally controlled HIV-1 replication to undetectable levels and compared them to treated patients with similarly low viral loads. HIV-specific cTfh (Tet + ), detected by Gag-major histocompatibility complex class II (MHC-II) tetramer labeling in the CD45RA - CXCR5 + CD4 + T cell population, proved more frequent in the controller group ( P = 0.002). The frequency of PD-1 expression in Tet + cTfh was increased in both groups (median, >75%) compared to total cTfh (<30%), but the intensity of PD-1 expression per cell remained higher in the treated patient group ( P = 0.02), pointing to the persistence of abnormal immune activation in treated patients. The function of cTfh, analyzed by the capacity to promote IgG secretion in cocultures with autologous memory B cells, did not show major differences between groups in terms of total IgG production but proved significantly more efficient in the controller group when measuring HIV-specific IgG production. The frequency of Tet + cTfh correlated with HIV-specific IgG production ( R = 0.71 for Gag-specific and R = 0.79 for Env-specific IgG, respectively). Taken together, our findings indicate that key cTfh-B cell interactions are preserved in controlled HIV infection, resulting in potent memory B cell responses that may play an underappreciated role in HIV control. IMPORTANCE The rare patients who spontaneously control HIV replication in the absence of therapy provide a unique model to identify determinants of an effective anti-HIV immune response. HIV controllers show signs of particularly efficient antiviral T cell responses, while their humoral response was until recently

  8. Traditional cardiovascular risk factors and coronary collateral circulation: Protocol for a systematic review and meta-analysis of case-control studies.

    Science.gov (United States)

    Xing, Zhenhua; Pei, Junyu; Tang, Liang; Hu, Xinqun

    2018-04-01

    Well-developed coronary collateral circulation usually results in fewer infarct size, improved cardiac function, and fewer mortality. Traditional coronary risk factors (diabetes, hypertension, and smoking) have some effects on coronary collateral circulation. However, the association between these risk factors and coronary collateral circulation are controversial. Given the confusing evidences regarding traditional cardiovascular risk factors on coronary collateral circulation, we performed this meta-analysis protocol to investigate the relationship between traditional risk factors of coronary artery disease and coronary collateral circulation. MEDINE, EMBASE, and Science Citation Index will be searched to identify relevant studies. The primary outcomes of this meta-analysis are well-developed coronary collateral circulation. Meta-analysis was performed to calculate the odds ratio (OR) and 95% confidence interval (CI) of traditional coronary risk factors (diabetes, smoking, hypertriton). Pooled ORs were computed as the Mantel-Haenszel-weighted average of the ORs for all included studies. Sensitivity analysis, quality assessment, publication bias analysis, and the Grading of Recommendations Assessment, Development and Evaluation approach (GRADE) will be performed to ensure the reliability of our results. This study will provide a high-quality synthesis of current evidence of traditional risk factors on collateral circulation. This conclusion of our systematic review and meta-analysis will provide evidence to judge whether traditional risk factors affects coronary collateral circulation.Ethics and dissemination: Ethical approval is not required because our systematic review and meta-analysis will be based on published data without interventions on patients. The findings of this study will be published in a peer-reviewed journal.

  9. Microwave circulator design

    CERN Document Server

    Linkhart, Douglas K

    2014-01-01

    Circulator design has advanced significantly since the first edition of this book was published 25 years ago. The objective of this second edition is to present theory, information, and design procedures that will enable microwave engineers and technicians to design and build circulators successfully. This resource contains a discussion of the various units used in the circulator design computations, as well as covers the theory of operation. This book presents numerous applications, giving microwave engineers new ideas about how to solve problems using circulators. Design examples are provided, which demonstrate how to apply the information to real-world design tasks.

  10. Autonomic control of vasomotion in the porcine coronary circulation during treadmill exercise: evidence for feed-forward beta-adrenergic control

    NARCIS (Netherlands)

    D.J.G.M. Duncker (Dirk); R. Stubenitsky (René); P.D. Verdouw (Pieter)

    1998-01-01

    textabstractTo date, no studies have investigated coronary vasomotor control of myocardial O2 delivery (MDO2) and its modulation by the autonomic nervous system in the porcine heart during treadmill exercise. We studied 8 chronically instrumented swine under resting

  11. Circulation pump mounting

    International Nuclear Information System (INIS)

    Skalicky, A.

    1976-01-01

    The suspension is described of nuclear reactor circulating pumps enabling their dilatation with a minimum reverse force consisting of spacing rods supported with one end in the anchor joints and provided with springs and screw joints engaging the circulating pump shoes. The spacing rods are equipped with side vibration dampers anchored in the shaft side wall and on the body of the circulating pump drive body. The negative reverse force F of the spacing rods is given by the relation F=Q/l.y, where Q is the weight of the circulating pump, l is the spatial distance between the shoe joints and anchor joints, and y is the deflection of the circulating pump vertical axis from the mean equilibrium position. The described suspension is advantageous in that that the reverse force for the deflection from the mean equilibrium position is minimal, dynamic behaviour is better, and construction costs are lower compared to suspension design used so far. (J.B.)

  12. Characteristics of the Current Sales and Circulation System in China

    Institute of Scientific and Technical Information of China (English)

    our reporter

    2001-01-01

    <正> 5 Former circulation enterprises finding new market position Those large-sized auto circulation enterprises, which used to lead the circulation system, have been suffering the twist and turns from the new system oriented by automakers. Their market shares shapely fell down and have emerged into chaos. Parts of them that are powerful enough have established new sales companies controlled by the jointly

  13. Gas Cooled Fast Breeder Reactor cost estimate for a circulator test facility (modified HTGR circulator test facility)

    International Nuclear Information System (INIS)

    1979-10-01

    This is a conceptual design cost estimate for a Helium Circulator Test Facility to be located at the General Atomic Company, San Diego, California. The circulator, drive motors, controllers, thermal barrier, and circulator service module installation costs are part of the construction cost included

  14. Seasonal overturning circulation in the Red Sea: 2. Winter circulation

    KAUST Repository

    Yao, Fengchao; Hoteit, Ibrahim; Pratt, Lawrence J.; Bower, Amy S.; Kö hl, Armin; Gopalakrishnan, Ganesh; Rivas, David

    2014-01-01

    The shallow winter overturning circulation in the Red Sea is studied using a 50 year high-resolution MITgcm (MIT general circulation model) simulation with realistic atmospheric forcing. The overturning circulation for a typical year, represented

  15. SpaceX Dragon Air Circulation System

    Science.gov (United States)

    Hernandez, Brenda; Piatrovich, Siarhei; Prina, Mauro

    2011-01-01

    The Dragon capsule is a reusable vehicle being developed by Space Exploration Technologies (SpaceX) that will provide commercial cargo transportation to the International Space Station (ISS). Dragon is designed to be a habitable module while it is berthed to ISS. As such, the Dragon Environmental Control System (ECS) consists of pressure control and pressure equalization, air sampling, fire detection, illumination, and an air circulation system. The air circulation system prevents pockets of stagnant air in Dragon that can be hazardous to the ISS crew. In addition, through the inter-module duct, the air circulation system provides fresh air from ISS into Dragon. To utilize the maximum volume of Dragon for cargo packaging, the Dragon ECS air circulation system is designed around cargo rack optimization. At the same time, the air circulation system is designed to meet the National Aeronautics Space Administration (NASA) inter-module and intra-module ventilation requirements and acoustic requirements. A flight like configuration of the Dragon capsule including the air circulation system was recently assembled for testing to assess the design for inter-module and intra-module ventilation and acoustics. The testing included the Dragon capsule, and flight configuration in the pressure section with cargo racks, lockers, all of the air circulation components, and acoustic treatment. The air circulation test was also used to verify the Computational Fluid Dynamics (CFD) model of the Dragon capsule. The CFD model included the same Dragon internal geometry that was assembled for the test. This paper will describe the Dragon air circulation system design which has been verified by testing the system and with CFD analysis.

  16. Research report of fiscal 1997. Study on total energy and material control (feasibility study on circulating society); 1997 nendo chosa hokokusho. Total energy and material control ni kansuru chosa (junkangata shakai kochiku kanosei chosa) chosa hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    In order to construct real sustainable global environment and human society in the 21st century called the century of environment, not only the innovation of manufacturing processes technically supporting such the construction but also the conception including the innovation of the whole society from a wide viewpoint are essential. As a total energy and material control system (TEMCOS) concept, the view of an energy-saving circulating society is attempted which minimizes a total energy and material flow in Japan, and the role and issue of manufacturing industry, in particular, material industry are extracted. As one of the targets of such a concept, the conception of an eco-town is also described. Paying attention on some important material industries including a mass material flow and consuming a large amount of energy such as metal, plastics and automobile industries, the study result on a material flow for every industry is arranged, and some effective issues contributing to minimize a material flow and control energy consumption and CO2 emission are extracted. 80 refs., 67 figs., 30 tabs.

  17. 饱和蒸汽压式波纹管疏水阀热动元件实验研究%Experimental study on the saturated vapor pressure type thermostatic bellows for steam traps

    Institute of Scientific and Technical Information of China (English)

    李树勋; 徐登伟; 把桥环

    2011-01-01

    针对液体膨胀式波纹管蒸汽疏水阀排量不稳定、漏汽率高等问题,分析波纹管热动元件的热工特性.基于Riedel蒸汽压方程和气液平衡方程,建立饱和蒸汽压式波纹管热动元件的热力学模型,设计相应实验系统,进行不同参数下的实验研究.结果表明,饱和蒸汽压式波纹管热动元件伸长量是相变温度的单值函数,近似呈指数关系;采用不同混合比、刚度及填充方式,可调节疏水阀的排水过冷度.%In view of the instabilities of displacement and high steam leakage rate for the liquid-expansion type ther-mostatic bellows steam traps, thermodynamic characteristical of thermostatic bellows was analyzed. Based on the Riedel equation and the vapor-liquid equilibrium equation, thermodynamic model of the saturated vapor pressure type thermostatic bellows was set up, corresponding experimental system was designed, and experimental studies with different parameters was carried out. The experimental results agree well with the theoretical analysis. The results show that the elongation A/I of the saturated vapor pressure type thermostatic bellows is monodrome function of phase transition temperature T, and relationship between the elongation A/I and the phase change temperature t is an exponential function. The subcooled temperature of steam trap can be adjusted by using different mixture ratio, different bellows' stiffness and different sufficient attire method. This paper establishes theoretical and experimental foundation for improving the performance of thermostatic bellows steam traps.

  18. Arctic circulation regimes.

    Science.gov (United States)

    Proshutinsky, Andrey; Dukhovskoy, Dmitry; Timmermans, Mary-Louise; Krishfield, Richard; Bamber, Jonathan L

    2015-10-13

    Between 1948 and 1996, mean annual environmental parameters in the Arctic experienced a well-pronounced decadal variability with two basic circulation patterns: cyclonic and anticyclonic alternating at 5 to 7 year intervals. During cyclonic regimes, low sea-level atmospheric pressure (SLP) dominated over the Arctic Ocean driving sea ice and the upper ocean counterclockwise; the Arctic atmosphere was relatively warm and humid, and freshwater flux from the Arctic Ocean towards the subarctic seas was intensified. By contrast, during anticylonic circulation regimes, high SLP dominated driving sea ice and the upper ocean clockwise. Meanwhile, the atmosphere was cold and dry and the freshwater flux from the Arctic to the subarctic seas was reduced. Since 1997, however, the Arctic system has been under the influence of an anticyclonic circulation regime (17 years) with a set of environmental parameters that are atypical for this regime. We discuss a hypothesis explaining the causes and mechanisms regulating the intensity and duration of Arctic circulation regimes, and speculate how changes in freshwater fluxes from the Arctic Ocean and Greenland impact environmental conditions and interrupt their decadal variability. © 2015 The Authors.

  19. Unique Protein Signature of Circulating Microparticles in Systemic Lupus Erythematosus

    DEFF Research Database (Denmark)

    Østergaard, Ole; Nielsen, Christoffer; Iversen, Line V

    2013-01-01

    To characterize the unique qualities of proteins associated with circulating subcellular material in systemic lupus erythematosus (SLE) patients compared with healthy controls and patients with other chronic autoimmune diseases.......To characterize the unique qualities of proteins associated with circulating subcellular material in systemic lupus erythematosus (SLE) patients compared with healthy controls and patients with other chronic autoimmune diseases....

  20. The ExPeCT (Examining Exercise, Prostate Cancer and Circulating Tumour Cells) trial: study protocol for a randomised controlled trial.

    LENUS (Irish Health Repository)

    Sheill, Gráinne

    2017-10-04

    Prostate cancer (PrCa) is the second most common cancer in Ireland. Many men present with locally advanced or metastatic cancer for whom curative surgery is inappropriate. Advanced cancer patients are encouraged to remain physically active and therefore there is a need to investigate how patients with metastatic disease tolerate physical activity programmes. Physical activity reduces levels of systemic inflammatory mediators and so an aerobic exercise intervention may represent an accessible and cost-effective means of ameliorating the pro-inflammatory effects of obesity and subsequently decrease poor cancer-specific outcomes in this patient population. This study will assess the feasibility and safety of introducing a structured aerobic exercise intervention to an advanced cancer population. This study will also examine if the evasion of immune editing by circulating tumour cells (CTCs) is an exercise-modifiable mechanism in obese men with prostate cancer.

  1. Electrodeposition of nickel onto steel, using a thermostatic cell and movable anode by a variable current.; Electrodeposicion de niquel sobre acero al carbon, empleando una celda termostatizada y un anodo movil, por medio de una corriente pulsada rectangular.

    Energy Technology Data Exchange (ETDEWEB)

    Vega G, J D

    1994-12-31

    In this work, metallic coatings of nickel was made over carbon steel using two different electrolytic solutions: The Watts`s bath and the nickel sulfamate bath, using a pulse variable current. The method use was the traditional method, its means a thermostatic cell and one movable anode, which is a few know technique nowadays, it allow realize depositions away from any laboratory or special workshop, it has the advantage to be a portable dispositive. At last of all the electro depositions the coatings quality was valuable by them physical properties like: adhesion, hardness, wrinkled and thickness. The best results was obtain by the Nickel sulfamate bath and movable anode, less in the thickness, which has higher on the thermostatic cell. The variable current was obtain by a Pulse Generator and a Cathodic galvanometer. (Author).

  2. Dynamic Behaviour of a Population of Controlled-by-price Demand Side Resources

    DEFF Research Database (Denmark)

    Sossan, Fabrizio; Han, Xue; Bindner, Henrik W.

    2014-01-01

    It is described that controlling or shedding by price the power consumption of a population of thermostatic loads introduces in the aggregate consumption dynamic effects th at cannot be disregarded if electrical flexible demand is meant to supply power system services. It is shown that inducing...

  3. Report on a survey in fiscal 1999. Part 3. Survey on total energy and material control (Survey on feasibility of structuring a circulation type society); 1999 nendo total energy and material control ni kansuru chosa hokokusho. 3. Junkangata shakai kochiku kanosei chosa

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Structuring a circulation type society indispensably requires effective utilization of energies and resources, to which approaches have been taken by industries independently. An approach upon structuring an industry crossing network may be taken effective for further effective utilization of the energies and resources. The present survey is intended to extract problems therefrom. It is also intended to perform surveys and studies on the following three points: (1) process-linking with different industries aimed at zero wasting in industrial complexes and electric furnaces dispersed adequately nationwide, (2) effective use and cascading utilization of energies and resources, and (3) a circulating type economic system simulation using metallic material industry as the core. It is further intended that problems shall be extracted; the results are compiled as the 'basic technology development for the metallic material circulating type economic system'; technological development themes are extracted; and the draft proposal shall be prepared. The total energy and materials control system (TECOS) activities are aimed at structuring a circulation type industrial structure, in which the following requirements are executed: the process-linking transcending the conventional industrial boundaries is performed; substances included in respective materials and discharges, and energies used in the processes are controlled comprehensively; the energies are utilized at ultra-high efficiency; and minimization of all the discharges is realized. (NEDO)

  4. Report on a survey in fiscal 1999. Part 3. Survey on total energy and material control (Survey on feasibility of structuring a circulation type society); 1999 nendo total energy and material control ni kansuru chosa hokokusho. 3. Junkangata shakai kochiku kanosei chosa

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Structuring a circulation type society indispensably requires effective utilization of energies and resources, to which approaches have been taken by industries independently. An approach upon structuring an industry crossing network may be taken effective for further effective utilization of the energies and resources. The present survey is intended to extract problems therefrom. It is also intended to perform surveys and studies on the following three points: (1) process-linking with different industries aimed at zero wasting in industrial complexes and electric furnaces dispersed adequately nationwide, (2) effective use and cascading utilization of energies and resources, and (3) a circulating type economic system simulation using metallic material industry as the core. It is further intended that problems shall be extracted; the results are compiled as the 'basic technology development for the metallic material circulating type economic system'; technological development themes are extracted; and the draft proposal shall be prepared. The total energy and materials control system (TECOS) activities are aimed at structuring a circulation type industrial structure, in which the following requirements are executed: the process-linking transcending the conventional industrial boundaries is performed; substances included in respective materials and discharges, and energies used in the processes are controlled comprehensively; the energies are utilized at ultra-high efficiency; and minimization of all the discharges is realized. (NEDO)

  5. Linear feedback controls the essentials

    CERN Document Server

    Haidekker, Mark A

    2013-01-01

    The design of control systems is at the very core of engineering. Feedback controls are ubiquitous, ranging from simple room thermostats to airplane engine control. Helping to make sense of this wide-ranging field, this book provides a new approach by keeping a tight focus on the essentials with a limited, yet consistent set of examples. Analysis and design methods are explained in terms of theory and practice. The book covers classical, linear feedback controls, and linear approximations are used when needed. In parallel, the book covers time-discrete (digital) control systems and juxtapos

  6. First circulating beam in the AA

    CERN Multimedia

    CERN PhotoLab

    1980-01-01

    On 3 July 1980, two years after project authorization, beam circulated for the first time in the AA. It was a 3.56 GeV/c proton test beam. We see an expecting crowd, minutes before the happy event. The persons are too numerous to name them all, but the 3 most prominent ones are at the centre (left to right): Roy Billinge (Joint AA Project Leader, with his hand on the control box), Eifionydd Jones (white shirt), Simon van der Meer (spiritus rector and Joint AA Project Leader). The first antiprotons were injected, made to circulate and cooled soon after, on 14 July 1980.

  7. Association between circulating adipocytokine concentrations and microvascular complications in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of controlled cross-sectional studies.

    Science.gov (United States)

    Rodríguez, Alexander J; Nunes, Vania dos Santos; Mastronardi, Claudio A; Neeman, Teresa; Paz-Filho, Gilberto J

    2016-03-01

    The adipocytokines leptin and adiponectin have been variously associated with diabetic microvascular complications. No comprehensive clinical data exist examining the association between adipocytokines and the presence of these complications. This is a systematic review of cross-sectional studies comparing circulating adipocytokines in patients with type 2 diabetes mellitus (T2DM), with and without microvascular complications. Studies were retrieved from MEDLINE, EMBASE, Scopus and Cochrane databases. Study quality was evaluated using a modified Newcastle-Ottawa Scale. Meta-analysis was performed using an inverse-variance model, providing standardised mean differences (SMD) and 95% confidence intervals (CI). Heterogeneity was determined by I(2) statistic. Amongst 554 identified studies, 28 were included in the review. Study quality range was 3.5-9 (maximum 11). Higher leptin levels were associated with microalbuminuria (SMD=0.41; 95% CI=0.14-0.67; n=901; p=0.0003), macroalbuminuria (SMD=0.68; 95% CI=0.30-1.06; n=406; p=0.0004), and neuropathy (SMD=0.26; 95% CI=0.07-0.44; n=609; p=0.008). Higher adiponectin levels were associated with microalbuminuria (SMD=0.55; 95% CI=0.29-0.81, n=274; p1), macroalbuminuria (SMD=1.37; 95% CI=0.78-1.97, n=246; p1), neuropathy (SMD=0.25; 95% CI=0.14-0.36; n=1516; p1), and retinopathy (SMD=0.38; 95% CI=0.25-0.51; n=1306; p1). Meta-regression suggested no influence of body mass index and duration of diabetes on effect size, and a weak trend in terms of age on effect size. Our meta-analysis suggests leptin and adiponectin levels are higher in T2DM patients with microvascular complications. Studies were limited by cross-sectional design. Large prospective analyses are required to validate these findings. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  8. Radiology of liver circulation

    International Nuclear Information System (INIS)

    Hermine, C.L.

    1985-01-01

    This book proposes that careful evaluation of the arterioportogram is the cornerstone in assessing portal flow obstruction, being the most consistent of all observations including liver histology, portal venous pressure, size and number of portosystemic collaterals, and wedged hepatic venous pressure. Very brief chapters cover normal hepatic circulation and angiographic methods. Contrast volumes and flow rates for celiac, hepatic, and superior mesenteric injection are given, with the timing for venous phase radiographs. In the main body of the text, portal obstruction is divided very simply into presinusoidal (all proximal causes) and postsinusoidal (all distal causes, including Budd-Chiari). Changes are discussed regarding the splenic artery and spleen; hepatic artery and its branches; portal flow rate and direction; and arterioportal shunting and portosystemic collateral circulation in minimal, moderate, severe, and very severe portal obstruction and in recognizable entities such as prehepatic portal and hepatic venous obstructions. The major emphasis in this section is the recognition and understanding of flow changes by which level and severity of obstruction are assessed (not simply the anatomy of portosystemic collateral venous flow). Excellent final chapters discuss the question of portal hypertension without obstruction, and the contribution of arterioportography to the treatment of portal hypertension, again with an emphasis on hemodynamics before and after shunt surgery. There is a fascinating final chapter on segmental intrahepatic obstruction without portal hypertension that explains much of the unusual contrast enhancement sometimes seen in CT scanning of hepatic mass lesions

  9. Circulation of Stars

    Science.gov (United States)

    Boitani, P.

    2016-01-01

    Since the dawn of man, contemplation of the stars has been a primary impulse in human beings, who proliferated their knowledge of the stars all over the world. Aristotle sees this as the product of primeval and perennial “wonder” which gives rise to what we call science, philosophy, and poetry. Astronomy, astrology, and star art (painting, architecture, literature, and music) go hand in hand through millennia in all cultures of the planet (and all use catasterisms to explain certain phenomena). Some of these developments are independent of each other, i.e., they take place in one culture independently of others. Some, on the other hand, are the product of the “circulation of stars.” There are two ways of looking at this. One seeks out forms, the other concentrates on the passing of specific lore from one area to another through time. The former relies on archetypes (for instance, with catasterism), the latter constitutes a historical process. In this paper I present some of the surprising ways in which the circulation of stars has occurred—from East to West, from East to the Far East, and from West to East, at times simultaneously.

  10. Preconcentration and determination of vanadium and molybdenum in milk, vegetables and foodstuffs by ultrasonic-thermostatic-assisted cloud point extraction coupled to flame atomic absorption spectrometry.

    Science.gov (United States)

    Gürkan, Ramazan; Korkmaz, Sema; Altunay, Nail

    2016-08-01

    A new ultrasonic-thermostatic-assisted cloud point extraction procedure (UTA-CPE) was developed for preconcentration at the trace levels of vanadium (V) and molybdenum (Mo) in milk, vegetables and foodstuffs prior to determination via flame atomic absorption spectrometry (FAAS). The method is based on the ion-association of stable anionic oxalate complexes of V(V) and Mo(VI) with [9-(diethylamino)benzo[a]phenoxazin-5-ylidene]azanium; sulfate (Nile blue A) at pH 4.5, and then extraction of the formed ion-association complexes into micellar phase of polyoxyethylene(7.5)nonylphenyl ether (PONPE 7.5). The UTA-CPE is greatly simplified and accelerated compared to traditional cloud point extraction (CPE). The analytical parameters optimized are solution pH, the concentrations of complexing reagents (oxalate and Nile blue A), the PONPE 7.5 concentration, electrolyte concentration, sample volume, temperature and ultrasonic power. Under the optimum conditions, the calibration curves for Mo(VI) and V(V) are obtained in the concentration range of 3-340µgL(-1) and 5-250µgL(-1) with high sensitivity enhancement factors (EFs) of 145 and 115, respectively. The limits of detection (LODs) for Mo(VI) and V(V) are 0.86 and 1.55µgL(-1), respectively. The proposed method demonstrated good performances such as relative standard deviations (as RSD %) (≤3.5%) and spiked recoveries (95.7-102.3%). The accuracy of the method was assessed by analysis of two standard reference materials (SRMs) and recoveries of spiked solutions. The method was successfully applied into the determination of trace amounts of Mo(VI) and V(V) in milk, vegetables and foodstuffs with satisfactory results. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Experimental study of natural circulation circuit

    Energy Technology Data Exchange (ETDEWEB)

    Lemos, Wanderley F.; Su, Jian, E-mail: wlemos@lasme.coppe.ufrj.br, E-mail: sujian@lasme.coppe.ufrj.br [Coordenacao dos Programas de Pos-Graduacao de Engenharia (LASME/COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Lab. de Simulacao e Metodos Numericos; Faccini, Jose L.H., E-mail: faccini@ien.gov.br [Instituto de Engenharia Nuclear (LTE/IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Lab. de Termo-Hidraulica Experimental

    2011-07-01

    This work presents an experimental study about fluid flows behavior in natural circulation, under conditions of single-phase flow. The experiment was performed through experimental thermal-hydraulic circuit built at IEN. This test equipment has performance similar to passive system of residual heat removal present in Advanced Pressurized Water Reactors (APWR). This experimental study aims to observing and analyzing the natural circulation phenomenon, using this experimental circuit that was dimensioned and built based on concepts of similarity and scale. This philosophy allows the analysis of natural circulation behavior in single-phase flow conditions proportionally to the functioning real conditions of a nuclear reactor. The experiment was performed through procedures to initialization of hydraulic feeding of primary and secondary circuits and electrical energizing of resistors installed inside heater. Power controller has availability to adjust values of electrical power to feeding resistors, in order to portray several conditions of energy decay of nuclear reactor in a steady state. Data acquisition system allows the measurement and monitoring of the evolution of the temperature in various points through thermocouples installed in strategic points along hydraulic circuit. The behavior of the natural circulation phenomenon was monitored by graphical interface on computer screen, showing the temperature evolutions of measuring points and results stored in digital spreadsheets. The results stored in digital spreadsheets allowed the getting of data to graphic construction and discussion about natural circulation phenomenon. Finally, the calculus of Reynolds number allowed the establishment for a correlation of friction in function of geometric scales of length, heights and cross section of tubing, considering a natural circulation flow throughout in the region of hot leg. (author)

  12. Experimental study of natural circulation circuit

    International Nuclear Information System (INIS)

    Lemos, Wanderley F.; Su, Jian; Faccini, Jose L.H.

    2011-01-01

    This work presents an experimental study about fluid flows behavior in natural circulation, under conditions of single-phase flow. The experiment was performed through experimental thermal-hydraulic circuit built at IEN. This test equipment has performance similar to passive system of residual heat removal present in Advanced Pressurized Water Reactors (APWR). This experimental study aims to observing and analyzing the natural circulation phenomenon, using this experimental circuit that was dimensioned and built based on concepts of similarity and scale. This philosophy allows the analysis of natural circulation behavior in single-phase flow conditions proportionally to the functioning real conditions of a nuclear reactor. The experiment was performed through procedures to initialization of hydraulic feeding of primary and secondary circuits and electrical energizing of resistors installed inside heater. Power controller has availability to adjust values of electrical power to feeding resistors, in order to portray several conditions of energy decay of nuclear reactor in a steady state. Data acquisition system allows the measurement and monitoring of the evolution of the temperature in various points through thermocouples installed in strategic points along hydraulic circuit. The behavior of the natural circulation phenomenon was monitored by graphical interface on computer screen, showing the temperature evolutions of measuring points and results stored in digital spreadsheets. The results stored in digital spreadsheets allowed the getting of data to graphic construction and discussion about natural circulation phenomenon. Finally, the calculus of Reynolds number allowed the establishment for a correlation of friction in function of geometric scales of length, heights and cross section of tubing, considering a natural circulation flow throughout in the region of hot leg. (author)

  13. Effects of humeral intraosseous versus intravenous epinephrine on pharmacokinetics and return of spontaneous circulation in a porcine cardiac arrest model: A randomized control trial

    Directory of Open Access Journals (Sweden)

    Don Johnson

    2015-09-01

    Seven HIO swine, 4 IV swine, and no control swine had ROSC. There were no significant differences in ROSC, maximum concentration; except at 30 s, and time-to-concentration-maximum between the HIO and IV groups. Significant differences existed between the experimental groups and the control. The HIO delivers a higher concentration of epinephrine than the IV route at 30 s which may be a survival advantage. Clinicians may consider using the IO route to administer epinephrine during CA when there is no preexisting IV access or when IV access is unobtainable.

  14. The ocean circulation inverse problem

    National Research Council Canada - National Science Library

    Wunsch, C

    1996-01-01

    .... This book addresses the problem of inferring the state of the ocean circulation, understanding it dynamically, and even forecasting it through a quantitative combination of theory and observation...

  15. Protein-enriched diet, with the use of lean red meat, combined with progressive resistance training enhances lean tissue mass and muscle strength and reduces circulating IL-6 concentrations in elderly women: a cluster randomized controlled trial.

    Science.gov (United States)

    Daly, Robin M; O'Connell, Stella L; Mundell, Niamh L; Grimes, Carley A; Dunstan, David W; Nowson, Caryl A

    2014-04-01

    Physical inactivity, inadequate dietary protein, and low-grade systemic inflammation contribute to age-related muscle loss, impaired function, and disability. We assessed the effects of progressive resistance training (PRT) combined with a protein-enriched diet facilitated through lean red meat on lean tissue mass (LTM), muscle size, strength and function, circulating inflammatory markers, blood pressure, and lipids in elderly women. In a 4-mo cluster randomized controlled trial, 100 women aged 60-90 y who were residing in 15 retirement villages were allocated to receive PRT with lean red meat (∼160 g cooked) to be consumed 6 d/wk [resistance training plus lean red meat (RT+Meat) group; n = 53] or control PRT [1 serving pasta or rice/d; control resistance training (CRT) group; n = 47)]. All women undertook PRT 2 times/wk and received 1000 IU vitamin D3/d. The mean (± SD) protein intake was greater in the RT+Meat group than in the CRT group throughout the study (1.3 ± 0.3 compared with 1.1 ± 0.3 g · kg⁻¹ · d⁻¹, respectively; P < 0.05). The RT+Meat group experienced greater gains in total body LTM (0.45 kg; 95% CI: 0.07, 0.84 kg), leg LTM (0.22 kg; 95% CI: 0.02, 0.42 kg), and muscle strength (18%; 95% CI: 0.03, 0.34) than did the CRT group (all P < 0.05). The RT+Meat group also experienced a 10% greater increase in serum insulin-like growth factor I (P < 0.05) and a 16% greater reduction in the proinflammatory marker interleukin-6 (IL-6) (P < 0.05) after 4 mo. There were no between-group differences for the change in blood lipids or blood pressure. A protein-enriched diet equivalent to ∼1.3 g · kg⁻¹ · d⁻¹ achieved through lean red meat is safe and effective for enhancing the effects of PRT on LTM and muscle strength and reducing circulating IL-6 concentrations in elderly women. This trial was registered at the Australian Clinical Trials Registry as ACTRN12609000223235.

  16. Sino-Danish Brain Circulation

    DEFF Research Database (Denmark)

    Bertelsen, Rasmus Gjedssø; Du, Xiangyun; Søndergaard, Morten Karnøe

    2014-01-01

    China is faced with urgent needs to develop an economically and environmentally sustainable economy based on innovation and knowledge. Brain circulation and research and business investments from the outside are central for this development. Sino-American brain circulation and research...... and investment by overseas researchers and entrepreneurs are well described. In that case, the US is the center of global R&D and S&T. However, the brain circulation and research and investments between a small open Scandinavian economy, such as Denmark, and the huge developing economy of China are not well...... understood. In this case, Denmark is very highly developed, but a satellite in the global R&D and S&T system. With time and the growth of China as a R&D and S&T power house, both Denmark and China will benefit from brain circulation between them. Such brain circulation is likely to play a key role in flows...

  17. Natural Circulation with Boiling

    Energy Technology Data Exchange (ETDEWEB)

    Mathisen, R P

    1967-09-15

    A number of parameters with dominant influence on the power level at hydrodynamic instability in natural circulation, two-phase flow, have been studied experimentally. The geometrical dependent quantities were: the system driving head, the boiling channel and riser dimensions, the single-phase as well as the two phase flow restrictions. The parameters influencing the liquid properties were the system pressure and the test section inlet subcooling. The threshold of instability was determined by plotting the noise characteristics in the mass flow records against power. The flow responses to artificially obtained power disturbances at instability conditions were also measured in order to study the nature of hydrodynamic instability. The results presented give a review over relatively wide ranges of the main parameters, mainly concerning the coolant performance in both single and parallel boiling channel flow. With regard to the power limits the experimental results verified that the single boiling channel performance was intimately related to that of the parallel channels. In the latter case the additional inter-channel factors with attenuating effects were studied. Some optimum values of the parameters were observed.

  18. State of the Art Report for a Bearing for VHTR Helium Circulator

    International Nuclear Information System (INIS)

    Lee, Jae Seon; Song, Kee Nam; Kim, Yong Wan; Lee, Won Jae

    2008-10-01

    A helium circulator in a VHTR(Very High Temperature gas-cooled Reactor) plays a core role which translates thermal energy at high temperature from a nuclear core to a steam generator. Helium as a operating coolant circulates a primary circuit in high temperature and high pressure state, and controls thermal output of a nuclear core by controlling flow rate. A helium circulator is the only rotating machinery in a VHTR, and its reliability should be guaranteed for reliable operation of a reactor and stable production of hydrogen. Generally a main helium circulator is installed on the top of a steam generator vessel, and helium is circulated only by a main helium circulator in a normal operation state. An auxiliary or shutdown circulator is installed at the bottom of a reactor vessel, and it is an auxiliary circulator for shutting down a reactor in case of refueling or accelerating cooling down in case of fast cooling. Since a rotating shaft of a helium circulator is supported by bearings, bearings are the important machine elements which determines reliability of a helium circulator and a nuclear reactor. Various types of support bearings have been developed and applied for circulator bearings since 1960s, and it is still developing for developing VHTRs. So it is necessary to review and analyze the current technical state of helium circulator support bearings to develop bearings for Koran developing VHTR helium circulator

  19. Effects of pomegranate juice in circulating parameters, cytokines, and oxidative stress markers in endurance-based athletes: A randomized controlled trial.

    Science.gov (United States)

    Fuster-Muñoz, E; Roche, E; Funes, L; Martínez-Peinado, P; Sempere, J M; Vicente-Salar, N

    2016-05-01

    The aim of the present study was to assess the effects of pomegranate juice on the level of oxidative stress in the blood of endurance-based athletes. Pomegranate juice is rich in polyphenols, conferring it a higher antioxidant capacity than other beverages with polyphenolic antioxidants. A randomized double-blind, multicenter trial was performed in athletes from three different sport clubs located in southeastern of Spain. Plasma oxidative stress markers (protein carbonyls and malondialdehyde [MDA]) as well as C-reactive protein and sE-selectin were measured. Thirty-one athletes participated in the study. Participants were divided into three groups. The first group was supplemented with 200 mL/d pomegranate juice (PJ; n = 10) over a 21-d period, the second with 200 mL/d pomegranate juice diluted 1:1 with water (PJD; n = 11), and a control group that did not consume pomegranate juice (C; n = 10). Nine athletes were excluded due to protocol violations (n = 4 in the PJ group and n = 5 in the PJD group) because they did not observe the 24 h of rest before the last blood test. The control group increased levels of carbonyls (+0.7 ± 0.3 nmols/mg protein) and MDA (+3.2 ± 1.0 nmols/g protein), whereas the PJ and PJD groups maintained or decreased their levels, respectively. On the other hand, lactate levels increased in the PJ group (from 10.3 at day 0 to 21.2 mg/dL at day 22). A nonsignificant decrease was detected in sE-selectin and C-reactive protein in the groups consuming pomegranate juice. Consumption of pomegranate juice over a 21-d period improved MDA levels and carbonyls, and thus decreased the oxidative damage caused by exercise. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Seasonal overturning circulation in the Red Sea: 1. Model validation and summer circulation

    KAUST Repository

    Yao, Fengchao

    2014-04-01

    The overturning circulation in the Red Sea exhibits a distinct seasonally reversing pattern and is studied using high-resolution MIT general circulation model simulations. In the first part of this study, the vertical and horizontal structure of the summer overturning circulation and its dynamical mechanisms are presented from the model results. The seasonal water exchange in the Strait of Bab el Mandeb is successfully simulated, and the structures of the intruding subsurface Gulf of Aden intermediate water are in good agreement with summer observations in 2011. The model results suggest that the summer overturning circulation is driven by the combined effect of the shoaling of the thermocline in the Gulf of Aden resulting from remote winds in the Arabian Sea and an upward surface slope from the Red Sea to the Gulf of Aden set up by local surface winds in the Red Sea. In addition, during late summer two processes associated, respectively, with latitudinally differential heating and increased salinity in the southern Red Sea act together to cause the reversal of the contrast of the vertical density structure and the cessation of the summer overturning circulation. Dynamically, the subsurface northward pressure gradient force is mainly balanced by vertical viscosity resulting from the vertical shear and boundary friction in the Strait of Bab el Mandeb. Unlike some previous studies, the three-layer summer exchange flows in the Strait of Bab el Mandeb do not appear to be hydraulically controlled.

  1. Seasonal overturning circulation in the Red Sea: 1. Model validation and summer circulation

    KAUST Repository

    Yao, Fengchao; Hoteit, Ibrahim; Pratt, Larry J.; Bower, Amy S.; Zhai, Ping; Kö hl, Armin; Gopalakrishnan, Ganesh

    2014-01-01

    The overturning circulation in the Red Sea exhibits a distinct seasonally reversing pattern and is studied using high-resolution MIT general circulation model simulations. In the first part of this study, the vertical and horizontal structure of the summer overturning circulation and its dynamical mechanisms are presented from the model results. The seasonal water exchange in the Strait of Bab el Mandeb is successfully simulated, and the structures of the intruding subsurface Gulf of Aden intermediate water are in good agreement with summer observations in 2011. The model results suggest that the summer overturning circulation is driven by the combined effect of the shoaling of the thermocline in the Gulf of Aden resulting from remote winds in the Arabian Sea and an upward surface slope from the Red Sea to the Gulf of Aden set up by local surface winds in the Red Sea. In addition, during late summer two processes associated, respectively, with latitudinally differential heating and increased salinity in the southern Red Sea act together to cause the reversal of the contrast of the vertical density structure and the cessation of the summer overturning circulation. Dynamically, the subsurface northward pressure gradient force is mainly balanced by vertical viscosity resulting from the vertical shear and boundary friction in the Strait of Bab el Mandeb. Unlike some previous studies, the three-layer summer exchange flows in the Strait of Bab el Mandeb do not appear to be hydraulically controlled.

  2. Structural controls on fluid circulation at the Caviahue-Copahue Volcanic Complex (CCVC) geothermal area (Chile-Argentina), revealed by soil CO2 and temperature, self-potential, and helium isotopes

    Science.gov (United States)

    Roulleau, Emilie; Bravo, Francisco; Pinti, Daniele L.; Barde-Cabusson, Stéphanie; Pizarro, Marcela; Tardani, Daniele; Muñoz, Carlos; Sanchez, Juan; Sano, Yuji; Takahata, Naoto; de la Cal, Federico; Esteban, Carlos; Morata, Diego

    2017-07-01

    Natural geothermal systems are limited areas characterized by anomalously high heat flow caused by recent tectonic or magmatic activity. The heat source at depth is the result of the emplacement of magma bodies, controlled by the regional volcano-tectonic setting. In contrast, at a local scale a well-developed fault-fracture network favors the development of hydrothermal cells, and promotes the vertical advection of fluids and heat. The Southern Volcanic Zone (SVZ), straddling Chile and Argentina, has an important, yet unexplored and undeveloped geothermal potential. Studies on the lithological and tectonic controls of the hydrothermal circulation are therefore important for a correct assessment of the geothermal potential of the region. Here, new and dense self-potential (SP), soil CO2 and temperature (T) measurements, and helium isotope data measured in fumaroles and thermal springs from the geothermal area located in the north-eastern flank of the Copahue volcanic edifice, within the Caviahue Caldera (the Caviahue-Copahue Volcanic Complex - CCVC) are presented. Our results allowed to the constraint of the structural origin of the active thermal areas and the understanding of the evolution of the geothermal system. NE-striking faults in the area, characterized by a combination of SP, CO2, and T maxima and high 3He/4He ratios (up to 8.16 ± 0.21Ra, whereas atmospheric Ra is 1.382 × 10- 6), promote the formation of vertical permeability preferential pathways for fluid circulation. WNW-striking faults represent low-permeability pathways for hydrothermal fluid ascent, but promote infiltration of meteoric water at shallow depths, which dilute the hydrothermal input. The region is scattered with SP, CO2, and T minima, representing self-sealed zones characterized by impermeable altered rocks at depth, which create local barriers for fluid ascent. The NE-striking faults seem to be associated with the upflowing zones of the geothermal system, where the boiling process

  3. Temperature control in molecular dynamic simulations of non-equilibrium processes

    International Nuclear Information System (INIS)

    Toton, Dawid; Lorenz, Christian D; Rompotis, Nikolaos; Martsinovich, Natalia; Kantorovich, Lev

    2010-01-01

    Thermostats are often used in various condensed matter problems, e.g. when a biological molecule undergoes a transformation in a solution, a crystal surface is irradiated with energetic particles, a crack propagates in a solid upon applied stress, two surfaces slide with respect to each other, an excited local phonon dissipates its energy into a crystal bulk, and so on. In all of these problems, as well as in many others, there is an energy transfer between different local parts of the entire system kept at a constant temperature. Very often, when modelling such processes using molecular dynamics simulations, thermostatting is done using strictly equilibrium approaches serving to describe the NVT ensemble. In this paper we critically discuss the applicability of such approaches to non-equilibrium problems, including those mentioned above, and stress that the correct temperature control can only be achieved if the method is based on the generalized Langevin equation (GLE). Specifically, we emphasize that a meaningful compromise between computational efficiency and a physically appropriate implementation of the NVT thermostat can be achieved, at least for solid state and surface problems, if the so-called stochastic boundary conditions (SBC), recently derived from the GLE (Kantorovich and Rompotis 2008 Phys. Rev. B 78 094305), are used. For SBC, the Langevin thermostat is only applied to the outer part of the simulated fragment of the entire system which borders the surrounding environment (not considered explicitly) serving as a heat bath. This point is illustrated by comparing the performance of the SBC and some of the equilibrium thermostats in two problems: (i) irradiation of the Si(001) surface with an energetic CaF 2 molecule using an ab initio density functional theory based method, and (ii) the tribology of two amorphous SiO 2 surfaces coated with self-assembled monolayers of methyl-terminated hydrocarbon alkoxylsilane molecules using a classical atomistic

  4. Effects of Aerobic and Resistance Exercise on Metabolic Syndrome, Sarcopenic Obesity, and Circulating Biomarkers in Overweight or Obese Survivors of Breast Cancer: A Randomized Controlled Trial.

    Science.gov (United States)

    Dieli-Conwright, Christina M; Courneya, Kerry S; Demark-Wahnefried, Wendy; Sami, Nathalie; Lee, Kyuwan; Buchanan, Thomas A; Spicer, Darcy V; Tripathy, Debu; Bernstein, Leslie; Mortimer, Joanne E

    2018-03-20

    Purpose Metabolic syndrome is associated with an increased risk of cardiovascular disease, type 2 diabetes, and breast cancer recurrence in survivors of breast cancer. This randomized controlled trial assessed the effects of a 16-week combined aerobic and resistance exercise intervention on metabolic syndrome, sarcopenic obesity, and serum biomarkers among ethnically diverse, sedentary, overweight, or obese survivors of breast cancer. Methods Eligible survivors of breast cancer (N = 100) were randomly assigned to exercise (n = 50) or usual care (n = 50). The exercise group participated in supervised moderate-to-vigorous-65% to 85% of heart rate maximum-aerobic and resistance exercise three times per week for 16 weeks. Metabolic syndrome z-score (primary outcome), sarcopenic obesity, and serum biomarkers were measured at baseline, postintervention (4 months), and 3-month follow-up (exercise only). Results Participants were age 53 ± 10.4 years, 46% were obese, and 74% were ethnic minorities. Adherence to the intervention was 95%, and postintervention assessments were available in 91% of participants. Postintervention metabolic syndrome z-score was significantly improved in exercise versus usual care (between-group difference, -4.4; 95% CI, -5.9 to -2.7; P metabolic syndrome variables remained significantly improved compared with baseline in the exercise group ( P exercise effectively attenuated metabolic syndrome, sarcopenic obesity, and relevant biomarkers in an ethnically diverse sample of sedentary, overweight, or obese survivors of breast cancer. Our findings suggest a targeted exercise prescription for improving metabolic syndrome in survivors of breast cancer and support the incorporation of supervised clinical exercise programs into breast cancer treatment and survivorship care plans.

  5. Circulating adiponectin levels in type 2 diabetes mellitus patients with or without non-alcoholic fatty liver disease: Results of a small, open-label, randomized controlled intervention trial in a subgroup receiving short-term exenatide.

    Science.gov (United States)

    Savvidou, Savvoula; Karatzidou, Kyparissia; Tsakiri, Kalliopi; Gagalis, Asterios; Hytiroglou, Prodromos; Goulis, John

    2016-03-01

    Diabetes mellitus type 2 (DMT2) and non-alcoholic fatty liver disease (NAFLD) are both characterized by decreased circulating adiponectin. Recently, glucagon-like peptide-1 receptor agonists have been shown to induce adiponectin's expression. However, their interaction on clinical grounds needs to be further elucidated. DMT2 patients with abnormal aminotransferases were screened for NAFLD and subjected to liver biopsy (group A, n=17). A subgroup of patients (n=110), after assessed for eligibility criteria, was blindly randomized to receive either 6-month exenatide supplementation on glargine insulin (group B) or intense, self-regulated, insulin therapy alone (group C). Baseline patient characteristics: 49(38.6%) males, aged 63.1 ± 7.5 years-old, BMI 32.9 ± 4.9 kg/m(2), HbA1c 8.1 ± 1.2% (65 ± 14 mmol/mol), median ALT 23 U/L (range 5-126), AST 20 U/L (7-72). Group A had biopsy-proven NAFLD with a median Activity Score of 5 and fibrosis stage 3. Presence of NAFLD was accompanied by a significant decline in adiponectin (p<0.001), which was negatively correlated with the degree of ALT in all groups (Spearman's correlation, rs=-0.644, p<0.001). In the subgroup intervention trial, adiponectin was significantly raised in both groups B and C (t-Student for paired samples, p=0.001) by Δ=+24.2% (interquartile range 14.8-53.2%). This elevation was not associated with the type of intervention but with weight loss, glycemic control and reduction of C-reactive protein (one-way ANCOVA). Supplementation of exenatide to glargine insulin compared to standard insulin was: (i) effective in inducing weight loss, (ii) non-inferior in lowering HbA1c and (iii) non-inferior in increasing circulating adiponectin. Higher adiponectin was associated with lower ALT, suggesting a hepato-protective role for this cytokine. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  6. Circulation policies in health science libraries.

    Science.gov (United States)

    Watkins, C; Coker, N C

    1970-10-01

    There is general agreement that library policies have considerable influence on the use of libraries. Medical school (health science) libraries of this country were surveyed as to their policies in respect to whether faculty and student use were regulated by a single policy, circulation regulations, hours library was accessible to users, accessibility of reserve material, interlibrary loan, policy on overdue material, and exit control. THE LIBRARIES WERE THEN DIVIDED INTO THREE GROUPS, HIGH, MIDDLE, AND LOW ACCORDING TO THE FOLLOWING CHARACTERISTICS: size of student body, size of faculty, size of holdings, size of library staff, annual budget, and annual circulation. Our findings would indicate that schools falling in a high category based upon these criteria tend to be more restrictive in their policies and to have different regulations for faculty and students than do schools in the low category.These findings warrant further study.

  7. Consumption of extra-virgin olive oil rich in phenolic compounds improves metabolic control in patients with type 2 diabetes mellitus: a possible involvement of reduced levels of circulating visfatin.

    Science.gov (United States)

    Santangelo, C; Filesi, C; Varì, R; Scazzocchio, B; Filardi, T; Fogliano, V; D'Archivio, M; Giovannini, C; Lenzi, A; Morano, S; Masella, R

    2016-11-01

    Phenolic compounds naturally contained in extra-virgin olive oil (EVOO) have demonstrated anti-inflammatory and antioxidant properties. The present study aimed at evaluating the effects of a polyphenol-rich extra-virgin olive oil (EVOO) (high-polyphenol EVOO, HP-EVOO) on the metabolic control and the production of specific pro-/anti-inflammatory adipokines in overweight patients with type 2 diabetes mellitus (T2D). Eleven overweight T2D patients not in treatment with insulin were invited to follow their habitual diet for a total of 8 weeks. During the first 4 weeks (wash-out period), they were asked to consume refined olive oil (ROO, polyphenols not detectable) and then to replace ROO with HP-EVOO (25 mL/day, 577 mg of phenolic compounds/kg) for the remaining 4 weeks. Anthropometric parameters, fasting glycaemia, glycated haemoglobin (HbA1c), high-sensitive C-reactive protein, plasma lipid profile, liver function and serum levels of TNF-α, IL-6, adiponectin, visfatin and apelin were assessed at the end of each 4-week period. HP-EVOO consumption significantly reduced fasting plasma glucose (P = 0.023) and HbA1c (P = 0.039) levels as well as BMI (P = 0.012) and body weight (P = 0.012). HP-EVOO ingestion determined a reduction in serum level of aspartate aminotransferase (AST, P = 0.0056) and alanine aminotransferase (ALT, P = 0.024). Serum visfatin levels strongly decreased after HP-EVOO ingestion (P = 0.0021). Daily consumption of polyphenol-rich EVOO might improve metabolic control and circulating inflammatory adipokines profile in overweight T2D patients.

  8. Elimination of Oscillations in a Central Heating System using Pump Control

    DEFF Research Database (Denmark)

    Andersen, Palle; Pedersen, Tom Søndergaard; Stoustrup, Jakob

    2000-01-01

    In central heating systems with thermostatic valve temperature control it is a well known fact that room temperature oscillations may occur when the heat demand becomes low due to the non-linear behavior of the control loop. This is not only discomforting but it also increases the energy cost...... of heating the room. Using the pump speed as an active part in control is it shown that the room temperature may be stabilized in a wider interval of heat demand. The idea is to control the pump speed in a way that keeps the thermostatic valve within a suitable operating area using an estimate of the valve...... position. The position is estimated from the pump terminals, using the pump flow and the pump differential pressure. The concept is tested on a small central heating test bench. The results show that it is possible to stabilize the room temperature even at part load conditions...

  9. Exercise increases circulating GDF15 in humans

    Directory of Open Access Journals (Sweden)

    Maximilian Kleinert

    2018-03-01

    Full Text Available Objective: The growth differentiation factor 15 (GDF15 is a stress-sensitive circulating factor that regulates systemic energy balance. Since exercise is a transient physiological stress that has pleiotropic effects on whole-body energy metabolism, we herein explored the effect of exercise on a circulating GDF15 levels and b GDF15 release from skeletal muscle in humans. Methods: Seven healthy males either rested or exercised at 67% of their VO2max for 1 h and blood was sampled from the femoral artery and femoral vein before, during, and after exercise. Plasma GDF15 concentrations were determined in these samples. Results: Plasma GDF15 levels increased 34% with exercise (p < 0.001 and further increased to 64% above resting values at 120 min (p < 0.001 after the cessation of exercise. There was no difference between the arterial and venous GDF15 concentration before, during, and after exercise. During a resting control trial, GDF15 levels measured in the same subjects were unaltered. Conclusions: Vigorous submaximal exercise increases circulating GDF15 levels in humans, but skeletal muscle tissue does not appear to be the source. Keywords: Skeletal muscle, Growth differentiation factor 15, Recovery, Physical activity

  10. Development of CO2 circulators

    International Nuclear Information System (INIS)

    Donaldson, J.

    1988-01-01

    The development of the basic machine types we have supplied has not been without problems. The Windscale AGR (the prototype AGR) was a small 1.2 MW vertically up circulator with an inlet temperature of 237 deg. C (459 deg. F). Oil leakage problems occurred and were cured in the works test facility and the machine went into service with no other problems. The Horizontal 5 MW machines for Hinkley/Hunterston were not so fortunate with vibration problems, interface corrosion problems (effecting the whole reactor) and material dimensional stability problems. Oil ingress problems did not show up in test work but were later reported from site. These reports were initially exagerated due to the measuring techniques which took the operators some time to resolve. In the vertical 5 MW machines for Hartlepool and Heysham 1 there are two interesting factors, firstly a spar failure and secondly shaft axial stability. Many of the problems were due to modifications at site or our inability to model all aspects of site installation from which lessons for the future can be learned. The latest stations Torness and Heysham II incorporate these lessons. The machines have been designed with so much margin that during the resolution of the reactor control rod gag problems the machines were run continuously at 20% overload (6.3 MW). From an initial accident case of 350 deg. C inlet temperature, this increased to 458 deg. C and now stands at 585 deg. C. No modifications to the impeller were required. The site experience to date is good with no operational problems reported. (author). 4 figs

  11. The Invertibility, Explicit Determinants, and Inverses of Circulant and Left Circulant and g-Circulant Matrices Involving Any Continuous Fibonacci and Lucas Numbers

    Directory of Open Access Journals (Sweden)

    Zhaolin Jiang

    2014-01-01

    Full Text Available Circulant matrices play an important role in solving delay differential equations. In this paper, circulant type matrices including the circulant and left circulant and g-circulant matrices with any continuous Fibonacci and Lucas numbers are considered. Firstly, the invertibility of the circulant matrix is discussed and the explicit determinant and the inverse matrices by constructing the transformation matrices are presented. Furthermore, the invertibility of the left circulant and g-circulant matrices is also studied. We obtain the explicit determinants and the inverse matrices of the left circulant and g-circulant matrices by utilizing the relationship between left circulant, g-circulant matrices and circulant matrix, respectively.

  12. Modelling and control of refrigerant circuits

    Energy Technology Data Exchange (ETDEWEB)

    Gruhle, W D; Isermann, R

    1987-01-01

    Conventional evaporator control systems involving a thermostatic expansion valve often to not work satisfactorily in terms of stability and evaporator utilization. To improve this, the author first studies the cause of this behaviour by means of theoretic modelling which is greatly determined by processes occurring within the evaporator and by structural combinations. After verification of the simulated model by means of measurements performed on a pilot plant, the results obtained are used to build up a new control system. Various experiments reveal a clearly improved evaporator utilization at greater control stability. (orig.).

  13. Fuzzy multivariable control of domestic heat pumps

    International Nuclear Information System (INIS)

    Underwood, C.P.

    2015-01-01

    Poor control has been identified as one of the reasons why recent field trials of domestic heat pumps in the UK have produced disappointing results. Most of the technology in use today uses a thermostatically-controlled fixed speed compressor with a mechanical expansion device. This article investigates improved control of these heat pumps through the design and evaluation of a new multivariable fuzzy logic control system utilising a variable speed compressor drive with capacity control linked through to evaporator superheat control. A new dynamic thermal model of a domestic heat pump validated using experimental data forms the basis of the work. The proposed control system is evaluated using median and extreme daily heating demand profiles for a typical UK house compared with a basic thermostatically-controlled alternative. Results show good tracking of the heating temperature and superheat control variables, reduced cycling and an improvement in performance averaging 20%. - Highlights: • A new dynamic model of a domestic heat pump is developed and validated. • A new multivariable fuzzy logic heat pump control system is developed/reported. • The fuzzy controller regulates both plant capacity and evaporator superheat degree. • Thermal buffer storage is also considered as well as compressor cycling. • The new controller shows good variable tracking and a reduction in energy of 20%.

  14. Proper Sizing of Circulation Pumps

    DEFF Research Database (Denmark)

    Tommerup, Henrik M.; Nørgaard, Jørgen

    2007-01-01

    The paper describes the preliminary results from field tests of replacing various types of old pumps used for circulating water in heating systems in single- and double-family houses with new types of pumps. The tests were carried out in Denmark for the Danish Electricity Savings Trust, but the r......The paper describes the preliminary results from field tests of replacing various types of old pumps used for circulating water in heating systems in single- and double-family houses with new types of pumps. The tests were carried out in Denmark for the Danish Electricity Savings Trust...

  15. Circulating current battery heater

    Science.gov (United States)

    Ashtiani, Cyrus N.; Stuart, Thomas A.

    2001-01-01

    A circuit for heating energy storage devices such as batteries is provided. The circuit includes a pair of switches connected in a half-bridge configuration. Unidirectional current conduction devices are connected in parallel with each switch. A series resonant element for storing energy is connected from the energy storage device to the pair of switches. An energy storage device for intermediate storage of energy is connected in a loop with the series resonant element and one of the switches. The energy storage device which is being heated is connected in a loop with the series resonant element and the other switch. Energy from the heated energy storage device is transferred to the switched network and then recirculated back to the battery. The flow of energy through the battery causes internal power dissipation due to electrical to chemical conversion inefficiencies. The dissipated power causes the internal temperature of the battery to increase. Higher internal temperatures expand the cold temperature operating range and energy capacity utilization of the battery. As disclosed, either fixed frequency or variable frequency modulation schemes may be used to control the network.

  16. Sensitivity experiments with an adaptation model of circulation of western tropical Indian Ocean

    Digital Repository Service at National Institute of Oceanography (India)

    Bahulayan, N.; Shaji, C.; Rao, A.D.; Dube, S.K.

    circulation at 10 m depth is controlled by both wind stress and sea surface topography. Circulation at 50 m depth is mainly controlled by thermohaline forcing and sea surface topography. The current speed in the western tropical Indian Ocean is of the order...

  17. Distinct features of circulating microparticles and their relationship to clinical manifestations in systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Nielsen, Christoffer T; Østergaard, Ole; Johnsen, Christina

    2011-01-01

    Characterization of the abundance, origin, and annexin V (AnxV)-binding capabilities of circulating microparticles (MPs) in SLE patients and healthy controls and to determine any associations with clinical parameters.......Characterization of the abundance, origin, and annexin V (AnxV)-binding capabilities of circulating microparticles (MPs) in SLE patients and healthy controls and to determine any associations with clinical parameters....

  18. Deep water characteristics and circulation in the South China Sea

    Science.gov (United States)

    Wang, Aimei; Du, Yan; Peng, Shiqiu; Liu, Kexiu; Huang, Rui Xin

    2018-04-01

    This study investigates the deep circulation in the South China Sea (SCS) using oceanographic observations combined with results from a bottom layer reduced gravity model. The SCS water, 2000 m below the surface, is quite different from that in the adjacent Pacific Ocean, and it is characterized by its low dissolved oxygen (DO), high temperature and low salinity. The horizontal distribution of deep water properties indicates a basin-scale cyclonic circulation driven by the Luzon overflow. The results of the bottom layer reduced gravity model are consistent with the existence of the cyclonic circulation in the deep SCS. The circulation is stronger at the northern/western boundary. After overflowing the sill of the Luzon Strait, the deep water moves broadly southwestward, constrained by the 3500 m isobath. The broadening of the southward flow is induced by the downwelling velocity in the interior of the deep basin. The main deep circulation bifurcates into two branches after the Zhongsha Islands. The southward branch continues flowing along the 3500 m isobath, and the eastward branch forms the sub-basin scale cyclonic circulation around the seamounts in the central deep SCS. The returning flow along the east boundary is fairly weak. The numerical experiments of the bottom layer reduced gravity model reveal the important roles of topography, bottom friction, and the upwelling/downwelling pattern in controlling the spatial structure, particularly the strong, deep western boundary current.

  19. Predisposing factors in posterior circulation infarcts: a vascular morphological assessment

    Energy Technology Data Exchange (ETDEWEB)

    Coban, Goekcen; Cifci, Egemen; Yildirim, Erkan; Agildere, Ahmet Muhtesem [Baskent University Faculty of Medicine, Department of Radiology, Konya (Turkey)

    2015-05-01

    The aim of the study is to assess the effect of shape, diameter, elongation and deviation criteria of basilar artery (BA), convergence angle and diameter variations of vertebral arteries, and concurrent chronic diseases on posterior circulation infarcts. Between January 2010 and May 2013, 186 patients who underwent brain and diffusion magnetic resonance imaging (MRI) with suspected cerebrovascular accident and were diagnosed with posterior circulation infarct and 120 infarct negative control subjects were included in this case-control retrospective study. Vertebral artery (VA) and BA diameter, right (R) and left (L) VA angles at the level of bifurcation, and BA elongation-deviation, and shape of BA were assessed in a total of 306 subjects. Ischemic lesions in the posterior circulation were classified according to their anatomical location and vascular perfusion areas. No significant difference was noted between the control and patient groups with respect to BA diameter (p = 0.676). The most effective risk factors for posterior circulation infarcts were as follows: BA elongation of 2 or 3, BA transverse location of 2 or 3, increase in left VA angle, and history of hypertension, hypercholesterolemia, and diabetes mellitus. Our results suggest that prominent elongation and deviation, C and J shape of BA, and increased L VA angle may be the predictors of at-risk patients in posterior circulation infarcts. Reporting marked morphological BA and VA variations detected at routine brain MRI will aid in selection of patients. Timely detection and treatment of at-risk patients may be life-saving. (orig.)

  20. Predisposing factors in posterior circulation infarcts: a vascular morphological assessment

    International Nuclear Information System (INIS)

    Coban, Goekcen; Cifci, Egemen; Yildirim, Erkan; Agildere, Ahmet Muhtesem

    2015-01-01

    The aim of the study is to assess the effect of shape, diameter, elongation and deviation criteria of basilar artery (BA), convergence angle and diameter variations of vertebral arteries, and concurrent chronic diseases on posterior circulation infarcts. Between January 2010 and May 2013, 186 patients who underwent brain and diffusion magnetic resonance imaging (MRI) with suspected cerebrovascular accident and were diagnosed with posterior circulation infarct and 120 infarct negative control subjects were included in this case-control retrospective study. Vertebral artery (VA) and BA diameter, right (R) and left (L) VA angles at the level of bifurcation, and BA elongation-deviation, and shape of BA were assessed in a total of 306 subjects. Ischemic lesions in the posterior circulation were classified according to their anatomical location and vascular perfusion areas. No significant difference was noted between the control and patient groups with respect to BA diameter (p = 0.676). The most effective risk factors for posterior circulation infarcts were as follows: BA elongation of 2 or 3, BA transverse location of 2 or 3, increase in left VA angle, and history of hypertension, hypercholesterolemia, and diabetes mellitus. Our results suggest that prominent elongation and deviation, C and J shape of BA, and increased L VA angle may be the predictors of at-risk patients in posterior circulation infarcts. Reporting marked morphological BA and VA variations detected at routine brain MRI will aid in selection of patients. Timely detection and treatment of at-risk patients may be life-saving. (orig.)

  1. Predisposing factors in posterior circulation infarcts: a vascular morphological assessment.

    Science.gov (United States)

    Çoban, Gökçen; Çifçi, Egemen; Yildirim, Erkan; Ağıldere, Ahmet Muhteşem

    2015-05-01

    The aim of the study is to assess the effect of shape, diameter, elongation and deviation criteria of basilar artery (BA), convergence angle and diameter variations of vertebral arteries, and concurrent chronic diseases on posterior circulation infarcts. Between January 2010 and May 2013, 186 patients who underwent brain and diffusion magnetic resonance imaging (MRI) with suspected cerebrovascular accident and were diagnosed with posterior circulation infarct and 120 infarct negative control subjects were included in this case-control retrospective study. Vertebral artery (VA) and BA diameter, right (R) and left (L) VA angles at the level of bifurcation, and BA elongation-deviation, and shape of BA were assessed in a total of 306 subjects. Ischemic lesions in the posterior circulation were classified according to their anatomical location and vascular perfusion areas. No significant difference was noted between the control and patient groups with respect to BA diameter (p = 0.676). The most effective risk factors for posterior circulation infarcts were as follows: BA elongation of 2 or 3, BA transverse location of 2 or 3, increase in left VA angle, and history of hypertension, hypercholesterolemia, and diabetes mellitus. Our results suggest that prominent elongation and deviation, C and J shape of BA, and increased L VA angle may be the predictors of at-risk patients in posterior circulation infarcts. Reporting marked morphological BA and VA variations detected at routine brain MRI will aid in selection of patients. Timely detection and treatment of at-risk patients may be life-saving.

  2. Twentieth century Walker Circulation change: data analysis and model experiments

    Energy Technology Data Exchange (ETDEWEB)

    Meng, Qingjia [Leibniz-Institut fuer Meereswissenschaften, Kiel (Germany); Chinese Research Academy of Environmental Sciences, River and Coastal Environment Research Center, Beijing (China); Chinese Academy of Sciences, Key Laboratory of Ocean Circulation and Waves, Institute of Oceanology, Qingdao (China); Latif, Mojib; Park, Wonsun; Keenlyside, Noel S.; Martin, Thomas [Leibniz-Institut fuer Meereswissenschaften, Kiel (Germany); Semenov, Vladimir A. [Leibniz-Institut fuer Meereswissenschaften, Kiel (Germany); A.M. Obukhov Institute of Atmospheric Physics, Russian Academy of Sciences, Moscow (Russian Federation)

    2012-05-15

    Recent studies indicate a weakening of the Walker Circulation during the twentieth century. Here, we present evidence from an atmospheric general circulation model (AGCM) forced by the history of observed sea surface temperature (SST) that the Walker Circulation may have intensified rather than weakened. Observed Equatorial Indo-Pacific Sector SST since 1870 exhibited a zonally asymmetric evolution: While the eastern part of the Equatorial Pacific showed only a weak warming, or even cooling in one SST dataset, the western part and the Equatorial Indian Ocean exhibited a rather strong warming. This has resulted in an increase of the SST gradient between the Maritime Continent and the eastern part of the Equatorial Pacific, one driving force of the Walker Circulation. The ensemble experiments with the AGCM, with and without time-varying external forcing, suggest that the enhancement of the SST gradient drove an anomalous atmospheric circulation, with an enhancement of both Walker and Hadley Circulation. Anomalously strong precipitation is simulated over the Indian Ocean and anomalously weak precipitation over the western Pacific, with corresponding changes in the surface wind pattern. Some sensitivity to the forcing SST, however, is noticed. The analysis of twentieth century integrations with global climate models driven with observed radiative forcing obtained from the Coupled Model Intercomparison Project (CMIP) database support the link between the SST gradient and Walker Circulation strength. Furthermore, control integrations with the CMIP models indicate the existence of strong internal variability on centennial timescales. The results suggest that a radiatively forced signal in the Walker Circulation during the twentieth century may have been too weak to be detectable. (orig.)

  3. Circulating Vitamin D and Risk of Epithelial Ovarian Cancer

    Directory of Open Access Journals (Sweden)

    Alan A. Arslan

    2009-01-01

    Full Text Available We conducted a nested case-control study within two prospective cohorts, the New York University Women's Health Study and the Northern Sweden Health and Disease Study, to examine the association between prediagnostic circulating levels of 25-hydroxy vitamin D (25(OHD and the risk of subsequent invasive epithelial ovarian cancer (EOC. The 25(OHD levels were measured in serum or plasma from 170 incident cases of EOC and 373 matched controls. Overall, circulating 25(OHD levels were not associated with the risk of EOC in combined cohort analysis: adjusted OR for the top tertile versus the reference tertile, 1.09 (95% CI, 0.59–2.01. In addition, there was no evidence of an interaction effect between VDR SNP genotype or haplotype and circulating 25(OHD levels in relation to ovarian cancer risk, although more complex gene-environment interactions may exist.

  4. The Donders model of the circulation in normo- and pathophysiology

    DEFF Research Database (Denmark)

    Noordergraaf, Gerrit J.; Ottesen, Johnny T.; Kortsmit, Wil J.P.M.

    2006-01-01

    the continuum of physiological conditions to cardiopulmonary resuscitation effects within the circulation.   Within the model, Harvey's view of the circulation has been broadened to include impedance-defined flow as a unifying concept. The cardiac function curve, the relation between ventricular filling...... and output, changes during exercise. First, it rotates counterclockwise and stretches along the output axis, second, it shifts along the filling axis. The first is induced by sympathetic control, the second by respiratory control. The model shows that depth of respiration, sympathetic stimulation of cardiac......A model of the closed human cardiovascular loop is developed. This model, using one set of 88 equations, allows variations from normal resting conditions to exercise, as well as to the extreme condition of a circulation following cardiac arrest. The principal purpose of the model is to evaluate...

  5. Circulating bile acids in healthy adults respond differently to a dietary pattern characterized by whole grains, legumes and fruits and vegetables compared to a diet high in refined grains and added sugars: a randomized, controlled, crossover feeding study.

    Science.gov (United States)

    Ginos, Bigina N R; Navarro, Sandi L; Schwarz, Yvonne; Gu, Haiwei; Wang, Dongfang; Randolph, Timothy W; Shojaie, Ali; Hullar, Meredith A J; Lampe, Paul D; Kratz, Mario; Neuhouser, Marian L; Raftery, Daniel; Lampe, Johanna W

    2018-02-16

    The effects of diets high in refined grains on biliary and colonic bile acids have been investigated extensively. However, the effects of diets high in whole versus refined grains on circulating bile acids, which can influence glucose homeostasis and inflammation through activation of farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5), have not been studied. We conducted a secondary analysis from a randomized controlled crossover feeding trial (NCT00622661) in 80 healthy adults (40 women/40 men, age 18-45 years) from the greater Seattle Area, half of which were normal weight (BMI 18.5-25.0 kg/m 2 ) and half overweight to obese (BMI 28.0-39.9 kg/m 2 ). Participants consumed two four-week controlled diets in randomized order: 1) a whole grain diet (WG diet), designed to be low in glycemic load (GL), high in whole grains, legumes, and fruits and vegetables, and 2) a refined grain diet (RG diet), designed to be high GL, high in refined grains and added sugars, separated by a four-week washout period. Quantitative targeted analysis of 55 bile acid species in fasting plasma was performed using liquid chromatography tandem mass spectrometry. Concentrations of glucose, insulin, and CRP were measured in fasting serum. Linear mixed models were used to test the effects of diet on bile acid concentrations, and determine the association between plasma bile acid concentrations and HOMA-IR and CRP. Benjamini-Hochberg false discovery rate (FDR) < 0.05 was used to control for multiple testing. A total of 29 plasma bile acids were reliably detected and retained for analysis. Taurolithocholic acid (TLCA), taurocholic acid (TCA) and glycocholic acid (GCA) were statistically significantly higher after the WG compared to the RG diet (FDR < 0.05). There were no significant differences by BMI or sex. When evaluating the association of bile acids and HOMA-IR, GCA, taurochenodeoxycholic acid, ursodeoxycholic acid (UDCA), 5β-cholanic acid-3β,12

  6. Circulating microRNAs in patients with active pulmonary tuberculosis.

    Science.gov (United States)

    Fu, Yurong; Yi, Zhengjun; Wu, Xiaoyan; Li, Jianhua; Xu, Fuliang

    2011-12-01

    Emerging evidence shows that microRNAs (miRNAs) play an important role in pathogen-host interactions. Circulating miRNAs have been repeatedly and stably detected in blood and hold promise to serve as molecular markers for diverse physiological and pathological conditions. To date, the relationship between circulating miRNAs and active pulmonary tuberculosis (TB) has not been reported. Using microarray-based expression profiling followed by real-time quantitative PCR validation, the levels of circulating miRNAs were compared between patients with active pulmonary tuberculosis and matched healthy controls. The receiver operating characteristic curve was used to evaluate the diagnostic effect of selected miRNA. Bioinformatic analysis was used to explore the potential roles of these circulating miRNAs in active pulmonary tuberculosis infection. Among 92 miRNAs significantly detected, 59 miRNAs were downregulated and 33 miRNAs were upregulated in the TB serum compared to their levels in the control serum. Interestingly, only two differentially expressed miRNAs were increased not only in the serum but also in the sputum of patients with active pulmonary tuberculosis compared to the levels for the healthy controls. Upregulated miR-29a could discriminate TB patients from healthy controls with reasonable sensitivity and specificity. A number of significantly enriched pathways regulated by these circulating miRNAs were predicted, and most of them were involved in acute-phase response, inflammatory response, and the regulation of the cytoskeleton. In all, for the first time our results revealed that a number of miRNAs were differentially expressed during active pulmonary tuberculosis infection, and circulating miR-29a has great potential to serve as a marker for the detection of active pulmonary tuberculosis infection.

  7. Journalism as Cultures of Circulation

    DEFF Research Database (Denmark)

    Bødker, Henrik

    2013-01-01

    The universe of journalism has always consisted of interspersed texts, meanings and practices. Yet, much journalism research has often isolated either texts and/or contexts and as such assumed relations between professional practices, informed (rational) readers and (conceived) core texts...... of journalism. It is, however, more important than ever to shift attention away from texts to the processes through which they are circulated. This is partly because the many cultural forms of journalism (textual, institutional, technological, material, behavioural and imagined) are undergoing significant......, likes, comments, searches, journalist roles, writing and reading positions and identities etc. Such forms will be traced within the mediation of a specific event with the overall aim of beginning a theorization of the landscape of journalism as highly interrelated cultures of circulation....

  8. Radioisotopic evaluation of portal circulation

    International Nuclear Information System (INIS)

    Maliska, C.; Rosenthal, D.

    1986-01-01

    The use of a radio-tracer of portal circulation through the intestine, should prevent cruel punctures in the portal-vein or spleen as it is usually the case with traditional methods in the study of portal-system. The absorption of I-131 and Tc-99m, previously cheked in rabbits presented similar results in dogs. The time of circulation between terminal large-intestine and the liver (t-RF) was determined by external counting at hepatic level by recording radioactivity variation-time. In healthy animals the t-RF was from 20to 60 seconds, with average time of 42 seconds. In 2 animals with partial binding of portal-vein the t-RF went up to 110 and 120 seconds. (Author) [pt

  9. Ocean circulation generated magnetic signals

    DEFF Research Database (Denmark)

    Manoj, C.; Kuvshinov, A.; Maus, S.

    2006-01-01

    Conducting ocean water, as it flows through the Earth's magnetic field, generates secondary electric and magnetic fields. An assessment of the ocean-generated magnetic fields and their detectability may be of importance for geomagnetism and oceanography. Motivated by the clear identification...... of ocean tidal signatures in the CHAMP magnetic field data we estimate the ocean magnetic signals of steady flow using a global 3-D EM numerical solution. The required velocity data are from the ECCO ocean circulation experiment and alternatively from the OCCAM model for higher resolution. We assume...... of the magnetic field, as compared to the ECCO simulation. Besides the expected signatures of the global circulation patterns, we find significant seasonal variability of ocean magnetic signals in the Indian and Western Pacific Oceans. Compared to seasonal variation, interannual variations produce weaker signals....

  10. Upper-Ocean Heat Balance Processes and the Walker Circulation in CMIP5 Model Projections

    Science.gov (United States)

    Robertson, F. R.; Roberts, J. B.; Funk, C.; Lyon, B.; Ricciardulli, L.

    2012-01-01

    Considerable uncertainty remains as to the importance of mechanisms governing decadal and longer variability of the Walker Circulation, its connection to the tropical climate system, and prospects for tropical climate change in the face of anthropogenic forcing. Most contemporary climate models suggest that in response to elevated CO2 and a warmer but more stratified atmosphere, the required upward mass flux in tropical convection will diminish along with the Walker component of the tropical mean circulation as well. Alternatively, there is also evidence to suggest that the shoaling and increased vertical stratification of the thermocline in the eastern Pacific will enable a muted SST increase there-- preserving or even enhancing some of the dynamical forcing for the Walker cell flow. Over the past decade there have been observational indications of an acceleration in near-surface easterlies, a strengthened Pacific zonal SST gradient, and globally-teleconnected dislocations in precipitation. But is this evidence in support of an ocean dynamical thermostat process posited to accompany anthropogenic forcing, or just residual decadal fluctuations associated with variations in warm and cold ENSO events and other stochastic forcing? From a modeling perspective we try to make headway on this question by examining zonal variations in surface energy fluxes and dynamics governing tropical upper ocean heat content evolution in the WCRP CMIP5 model projections. There is some diversity among model simulations; for example, the CCSM4 indicates net ocean warming over the IndoPacific region while the CSIRO model concentrates separate warming responses over the central Pacific and Indian Ocean regions. The models, as with observations, demonstrate strong local coupling between variations in column water vapor, downward surface longwave radiation and SST; but the spatial patterns of changes in the sign of this relationship differ among models and, for models as a whole, with

  11. Experimental study of two-phase natural circulation circuit

    Energy Technology Data Exchange (ETDEWEB)

    Lemos, Wanderley Freitas; Su, Jian, E-mail: wlemos@lasme.coppe.ufrj.br, E-mail: sujian@nuclear.ufrj.br [Coordenacao dos Programas de Pos-Graduacao em Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear; Faccini, Jose Luiz Horacio, E-mail: faccini@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), RIo de Janeiro, RJ (Brazil). Lab. de Termo-Hidraulica Experimental

    2012-07-01

    This paper reports an experimental study on the behavior of fluid flow in natural circulation under single-and two-phase flow conditions. The natural circulation circuit was designed based on concepts of similarity and scale in proportion to the actual operating conditions of a nuclear reactor. This test equipment has similar performance to the passive system for removal of residual heat presents in Advanced Pressurized Water Reactors (A PWR). The experiment was carried out by supplying water to primary and secondary circuits, as well as electrical power resistors installed inside the heater. Power controller has available to adjust the values for supply of electrical power resistors, in order to simulate conditions of decay of power from the nuclear reactor in steady state. Data acquisition system allows the measurement and control of the temperature at different points by means of thermocouples installed at several points along the circuit. The behavior of the phenomenon of natural circulation was monitored by a software with graphical interface, showing the evolution of temperature measurement points and the results stored in digital format spreadsheets. Besides, the natural circulation flow rate was measured by a flowmeter installed on the hot leg. A flow visualization technique was used the for identifying vertical flow regimes of two-phase natural circulation. Finally, the Reynolds Number was calculated for the establishment of a friction factor correlation dependent on the scale geometrical length, height and diameter of the pipe. (author)

  12. Experimental study of two-phase natural circulation circuit

    International Nuclear Information System (INIS)

    Lemos, Wanderley Freitas; Su, Jian; Faccini, Jose Luiz Horacio

    2012-01-01

    This paper reports an experimental study on the behavior of fluid flow in natural circulation under single-and two-phase flow conditions. The natural circulation circuit was designed based on concepts of similarity and scale in proportion to the actual operating conditions of a nuclear reactor. This test equipment has similar performance to the passive system for removal of residual heat presents in Advanced Pressurized Water Reactors (A PWR). The experiment was carried out by supplying water to primary and secondary circuits, as well as electrical power resistors installed inside the heater. Power controller has available to adjust the values for supply of electrical power resistors, in order to simulate conditions of decay of power from the nuclear reactor in steady state. Data acquisition system allows the measurement and control of the temperature at different points by means of thermocouples installed at several points along the circuit. The behavior of the phenomenon of natural circulation was monitored by a software with graphical interface, showing the evolution of temperature measurement points and the results stored in digital format spreadsheets. Besides, the natural circulation flow rate was measured by a flowmeter installed on the hot leg. A flow visualization technique was used the for identifying vertical flow regimes of two-phase natural circulation. Finally, the Reynolds Number was calculated for the establishment of a friction factor correlation dependent on the scale geometrical length, height and diameter of the pipe. (author)

  13. Observations of Local Seychelles Circulation

    Science.gov (United States)

    2015-09-30

    1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Observations of Local Seychelles Circulation Geno...goal for the proposed work is to develop predictive capabilities for physical oceanography for the Seychelles region in support of locally relevant...observations in the Seychelles region that will lead to long-term data collection efforts. In collaboration with local partnerships, we will carry out

  14. Circulating nucleic acids and evolution.

    Science.gov (United States)

    Anker, Philippe; Stroun, Maurice

    2012-06-01

    J.B. Lamarck in 1809 was the first to present a theory of evolution. He proposed it was due to the adaptation of species to environmental changes, this adaptation being acquired by the offspring. In 1868, Darwin suggested that cells excrete gemmules, which circulate through the body and reach the gonads where they are transmitted to the next generation. His main argument came from graft hybrids. In the fifties and sixties, Russian geneticists, rejecting neo-Darwinism, said that acquired characteristics were the basis of evolution. The main experiments on which they based their theory were the transmission of hereditary characteristics by a special technique of grafting between two varieties of plants. We repeated this kind of experiment and also succeeded in obtaining hereditary modifications of the pupil plants that acquired some characteristics of the mentor variety. Rather than adopting the views of the Russian scientists, we suggested that DNA was circulating between the mentor and pupil plants. Hirata's group have shown recently, by using molecular techniques such as cloning, RFLP PCR and sequencing some genes of their graft hybrids of pepper plants, that transfer of informative molecules from the mentor to the pupil plant does exist. Nucleic acids are actively released by cells; they circulate in the body. They can transform oncogenically or trigger antibody response but the only genetic transformation showing that DNA can go from the soma to the germen comes from graft hybrids. This suggests that circulating nucleic acids, in this case DNA, like Darwin's gemmules, play a role in the mechanism of evolution.

  15. Improvement of Classification of Enterprise Circulating Funds

    OpenAIRE

    Rohanova Hanna O.

    2014-01-01

    The goal of the article lies in revelation of possibilities of increase of efficiency of managing enterprise circulating funds by means of improvement of their classification features. Having analysed approaches of many economists to classification of enterprise circulating funds, systemised and supplementing them, the article offers grouping classification features of enterprise circulating funds. In the result of the study the article offers an expanded classification of circulating funds, ...

  16. Hall Effect Gyrators and Circulators

    Science.gov (United States)

    Viola, Giovanni; DiVincenzo, David P.

    2014-04-01

    The electronic circulator and its close relative the gyrator are invaluable tools for noise management and signal routing in the current generation of low-temperature microwave systems for the implementation of new quantum technologies. The current implementation of these devices using the Faraday effect is satisfactory but requires a bulky structure whose physical dimension is close to the microwave wavelength employed. The Hall effect is an alternative nonreciprocal effect that can also be used to produce desired device functionality. We review earlier efforts to use an Ohmically contacted four-terminal Hall bar, explaining why this approach leads to unacceptably high device loss. We find that capacitive coupling to such a Hall conductor has much greater promise for achieving good circulator and gyrator functionality. We formulate a classical Ohm-Hall analysis for calculating the properties of such a device, and show how this classical theory simplifies remarkably in the limiting case of the Hall angle approaching 90°. In this limit, we find that either a four-terminal or a three-terminal capacitive device can give excellent circulator behavior, with device dimensions far smaller than the ac wavelength. An experiment is proposed to achieve GHz-band gyration in millimeter (and smaller) scale structures employing either semiconductor heterostructure or graphene Hall conductors. An inductively coupled scheme for realizing a Hall gyrator is also analyzed.

  17. Demand Controlled Economizer Cycles: A Direct Digital Control Scheme for Heating, Ventilating, and Air Conditioning Systems,

    Science.gov (United States)

    1984-05-01

    Control Ignored any error of 1/10th degree or less. This was done by setting the error term E and the integral sum PREINT to zero If then absolute value of...signs of two errors jeq tdiff if equal, jump clr @preint else zero integal sum tdiff mov @diff,rl fetch absolute value of OAT-RAT ci rl,25 is...includes a heating coil and thermostatic control to maintain the air in this path at an elevated temperature, typically around 80 degrees Farenheit (80 F

  18. Encoders for block-circulant LDPC codes

    Science.gov (United States)

    Divsalar, Dariush (Inventor); Abbasfar, Aliazam (Inventor); Jones, Christopher R. (Inventor); Dolinar, Samuel J. (Inventor); Thorpe, Jeremy C. (Inventor); Andrews, Kenneth S. (Inventor); Yao, Kung (Inventor)

    2009-01-01

    Methods and apparatus to encode message input symbols in accordance with an accumulate-repeat-accumulate code with repetition three or four are disclosed. Block circulant matrices are used. A first method and apparatus make use of the block-circulant structure of the parity check matrix. A second method and apparatus use block-circulant generator matrices.

  19. Pipe Decontamination Involving String-Foam Circulation

    International Nuclear Information System (INIS)

    Turchet, J.P.; Estienne, G.; Fournel, B.

    2002-01-01

    Foam applications number for nuclear decontamination purposes has recently increased. The major advantage of foam decontamination is the reduction of secondary liquid wastes volumes. Among foam applications, we focus on foam circulation in contaminated equipment. Dynamic properties of the system ensures an homogeneous and rapid effect of the foam bed-drifted chemical reagents present in the liquid phase. This paper describes a new approach of foam decontamination for pipes. It is based on an alternated air and foam injections. We called it 'string-foam circulation'. A further reduction of liquid wastes is achieved compared to continuous foam. Secondly, total pressure loss along the pipe is controlled by the total foam length in the pipe. It is thus possible to clean longer pipes keeping the pressure under atmospheric pressure value. This ensures the non dispersion of contamination. This study describes experimental results obtained with a neutral foam as well with an acid foam on a 130 m long loop. Finally, the decontamination of a 44 meters pipe is presented. (authors)

  20. Booth Library On-Line Circulation System (BLOC

    Directory of Open Access Journals (Sweden)

    Paladugu V. Rao

    1971-06-01

    Full Text Available An on-line circulation system developed at a relatively small university library demonstrates that academic libraries with limited funds can develop automated systems utilizing parent institution's computer facilities in a time-sharing mode. In operation since September 1968, using an IBM 360/50 computer and associated peripheral equipment, it provides control over all stack books.

  1. Circulating tumor cells in melanoma patients.

    Directory of Open Access Journals (Sweden)

    Gary A Clawson

    Full Text Available Circulating tumor cells (CTCs are of recognized importance for diagnosis and prognosis of cancer patients. With melanoma, most studies do not show any clear relationship between CTC levels and stage of disease. Here, CTCs were enriched (∼400X from blood of melanoma patients using a simple centrifugation device (OncoQuick, and 4 melanocyte target RNAs (TYR, MLANA, MITF, and MIF were quantified using QPCR. Approximately one-third of melanoma patients had elevated MIF and MLANA transcripts (p<0.0001 and p<0.001, respectively compared with healthy controls. In contrast, healthy controls had uniformly higher levels of TYR and MITF than melanoma patients (p<0.0001. There was a marked shift of leukocytes into the CTC-enriched fractions (a 430% increase in RNA recovery, p<0.001, and no relationship between CTC levels and stage of disease was found. CTCs were captured on microfabricated filters and cultured. Captured melanoma CTCs were large cells, and consisted of 2 subpopulations, based on immunoreactivity. One subpopulation (∼50% stained for both pan-cytokeratin (KRT markers and the common leukocyte marker CD-45, whereas the second subpopulation stained for only KRT. Since similar cells are described in many cancers, we also examined blood from colorectal and pancreatic cancer patients. We observed analogous results, with most captured CTCs staining for both CD-45/KRT markers (and for the monocyte differentiation marker CD-14. Our results suggest that immature melanocyte-related cells (expressing TYR and MITF RNA may circulate in healthy controls, although they are not readily detectable without considerable enrichment. Further, as early-stage melanomas develop, immature melanocyte migration into the blood is somehow curtailed, whereas a significant proportion of patients develop elevated CTC levels (based on MIF and MLANA RNAs. The nature of the captured CTCs is consistent with literature describing leukocyte/macrophage-tumor cell fusion hybrids

  2. Water circulation control on carbonate-δ18O records in a low permeability clay formation and surrounding limestones: The Upper Dogger-Oxfordian sequence from the eastern Paris basin, France

    International Nuclear Information System (INIS)

    Lavastre, Veronique; Ader, Magali; Buschaert, Stephane; Petit, Eddy; Javoy, Marc

    2011-01-01

    carbonate-δ 18 O content trends observed for the Callovo-Oxfordian data show that changes were controlled by post-depositional fluid-rock interaction with water/rock ratio (0.02-0.15) similar to the present-day porewater/rock ratio. The 130 m thick Callovo-Oxfordian claystone appears remarkably homogenous regarding its hydrogeological properties. This study suggests an initial marine porewater replacement by meteoric water only after porosity was reduced to its present value, thus demonstrating that the Callovo-Oxfordian clay has mainly been isolated from advective meteoric water circulation. Only the upper 20 m of the Callovo-Oxfordian claystone Formation underwent heterogeneous water-rock exchange (W/R from 0.01 to 0.3), probably as a result of its mineralogical heterogeneity and proximity to the advective Oxfordian Limestone aquifer. This study of carbonate-δ 18 O confirms the hydrogeological barrier properties of the Callovo-Oxfordian clay and suggests that it has been a natural hydrological barrier since the earliest times of its diagenesis.

  3. Water circulation control on carbonate-{delta}{sup 18}O records in a low permeability clay formation and surrounding limestones: The Upper Dogger-Oxfordian sequence from the eastern Paris basin, France

    Energy Technology Data Exchange (ETDEWEB)

    Lavastre, Veronique, E-mail: veronique.lavastre@univ-st-etienne.fr [Universite de Lyon, Universite Jean Monnet, F-42023 Saint Etienne (France)] [CNRS, UMR 6524, LMV, F-42023 Saint Etienne (France)] [Laboratoire de Geochimie des Isotopes Stables, Institut de Physique du Globe de Paris and Universite Paris 7 - UMR CNRS 7154, 4, place Jussieu, 75252 Paris cedex 05 (France); Ader, Magali [Laboratoire de Geochimie des Isotopes Stables, Institut de Physique du Globe de Paris and Universite Paris 7 - UMR CNRS 7154, 4, place Jussieu, 75252 Paris cedex 05 (France); Buschaert, Stephane [Andra, Parc de la Croix Blanche, 7-8 rue Jean Monnet, 92 298 Chatenay-Malabry Cedex (France); Petit, Eddy; Javoy, Marc [Laboratoire de Geochimie des Isotopes Stables, Institut de Physique du Globe de Paris and Universite Paris 7 - UMR CNRS 7154, 4, place Jussieu, 75252 Paris cedex 05 (France)

    2011-05-15

    effective since Jurassic/Cretaceous transition times. Inversely, the carbonate-{delta}{sup 18}O content trends observed for the Callovo-Oxfordian data show that changes were controlled by post-depositional fluid-rock interaction with water/rock ratio (0.02-0.15) similar to the present-day porewater/rock ratio. The 130 m thick Callovo-Oxfordian claystone appears remarkably homogenous regarding its hydrogeological properties. This study suggests an initial marine porewater replacement by meteoric water only after porosity was reduced to its present value, thus demonstrating that the Callovo-Oxfordian clay has mainly been isolated from advective meteoric water circulation. Only the upper 20 m of the Callovo-Oxfordian claystone Formation underwent heterogeneous water-rock exchange (W/R from 0.01 to 0.3), probably as a result of its mineralogical heterogeneity and proximity to the advective Oxfordian Limestone aquifer. This study of carbonate-{delta}{sup 18}O confirms the hydrogeological barrier properties of the Callovo-Oxfordian clay and suggests that it has been a natural hydrological barrier since the earliest times of its diagenesis.

  4. Heparin defends against the toxicity of circulating histones in sepsis.

    Science.gov (United States)

    Wang, Feifei; Zhang, Naipu; Li, Biru; Liu, Lanbo; Ding, Lei; Wang, Ying; Zhu, Yimin; Mo, Xi; Cao, Qing

    2015-06-01

    Although circulating histones were demonstrated as major mediators of death in septic mice models, their roles in septic patients are not clarified. The present study sought to evaluate the clinical relevance of the circulating histone levels in septic children, and the antagonizing effects of heparin on circulating histones. Histone levels in the plasma of septic children were significantly higher than healthy controls, and positively correlated with disease severity. Histone treatment could activate NF-κB pathway of the endothelial cells and induce the secretion of large amount of cytokines that further amplify inflammation, subsequently leading to organ damage. Co-injection of low dose heparin with lethal dose histones could protect mouse from organ damage and death by antagonizing circulating histones, and similar effects were also observed in other septic models. Collectively, these findings indicated that circulating histones might serve as key factors in the pathogenesis of sepsis and their levels in plasma might be a marker for disease progression and prognosis. Furthermore, low dose heparin might be an effective therapy to hamper sepsis progression and reduce the mortality.

  5. Long circulating polymeric nanoparticles for gene/drug delivery.

    Science.gov (United States)

    Hu, Jiaming; Sheng, Yan; Shi, Junfeng; Yu, Bohao; Yu, Zhiqiang; Liao, Guochao

    2017-12-07

    The major limitation in the improving polymeric nanoparticles into an efficient gene/drug delivery carrier is the rapid opsonization, phagocytic uptake by mononuclear phagocyte system and subsequent clearance from the bloodstream. The prolonged circulation time of nanoparticles in the blood is a prerequisite to realizing a controlled and targeted (passive or active targeting) release of the encapsulated gene/drug at the desired site of action. In this review, the factors such as biological barriers and physical barriers including particle size, shape, zeta potential, and hydrophilicity will be discussed, which can cause effects on blood clearance and organ accumulation. Some natural and synthetic polymers utilized in long-circulating nanoparticles will also be discussed. The most popular method to mask or camouflage nanoparticles is the adsorbed, grafted or conjugated of poly (ethylene glycol) (PEG) or other hydrophilic polymers (e.g. polysaccharides) to the particle surface. Surface modification of nanoparticles with these polymers results in an increased blood circulation time by several orders of magnitude in comparison to the bare nanoparticles. However, the circulation half-life of nanoparticles still cannot satisfy the need for clinical use. At present, identification of novel potential coating materials is an emerging field of interest in the design of long-circulating polymer-based nanoparticulate gene/drug delivery. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  6. Circulation of water masses in the Baltic Proper revealed through iodine isotopes

    DEFF Research Database (Denmark)

    Yi, P.; Chen, X.G.; Aldahan, A.

    2013-01-01

    Tracer technology has been used to understand water circulation in marine systems where the tracer dose is commonly injected into the marine waters through controlled experiments, accidental releases or waste discharges. Anthropogenic discharges of 129I have been used to trace water circulation...

  7. Diarrhea caused by circulating agents.

    Science.gov (United States)

    Fabian, Elisabeth; Kump, Patrizia; Krejs, Guenter J

    2012-09-01

    Circulating agents cause intestinal secretion or changes in motility with decreased intestinal transit time, resulting in secretory-type diarrhea. Secretory diarrhea as opposed to osmotic diarrhea is characterized by large-volume, watery stools, often more than 1 L per day; by persistence of diarrhea when patients fast; and by the fact that on analysis of stool-water, measured osmolarity is identical to that calculated from the electrolytes present. Although sodium plays the main role in water and electrolyte absorption, chloride is the major ion involved in secretion. Copyright © 2012 Elsevier Inc. All rights reserved.

  8. Vasculitis of the mesenteric circulation.

    Science.gov (United States)

    Koster, Matthew J; Warrington, Kenneth J

    2017-02-01

    Vasculitis of the mesenteric circulation is an uncommon but life-threatening manifestation of systemic vasculitis. Initial symptoms are frequently non-specific and therefore patients often present to primary care physicians and gastroenterologists with abdominal pain or gastrointestinal bleeding. Given the severity of the conditions associated with mesenteric vasculitis, it is imperative to appropriately diagnose and initiate treatment of suspected cases. This review will focus on diseases commonly associated with vasculitis of the mesenteric vessels. Imaging characteristics and clinical features assisting in diagnosis as well as initial approaches to treatment are emphasized. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Autonomic Regulation of Splanchnic Circulation

    Directory of Open Access Journals (Sweden)

    Kathleen A Fraser

    1991-01-01

    Full Text Available The role of the autonomic nervous system in circulatory regulation of the splanchnic organs (stomach, small intestine, colon, liver, pancreas and spleen is reviewed. In general, the sympathetic nervous system is primarily involved in vasoconstriction, while the parasympathetic contributes to vasodilation. Vasoconstriction in the splanchnic circulation appears to be mediated by alpha-2 receptors and vasodilation by activation of primary afferent nerves with subsequent release of vasodilatory peptides, or by stimulation of beta-adrenergic receptors. As well, an important function of the autonomic nervous system is to provide a mechanism by which splanchnic vascular reserve can be mobilized during stress to maintain overall cardiovascular homeostasis.

  10. Fragment Length of Circulating Tumor DNA.

    Science.gov (United States)

    Underhill, Hunter R; Kitzman, Jacob O; Hellwig, Sabine; Welker, Noah C; Daza, Riza; Baker, Daniel N; Gligorich, Keith M; Rostomily, Robert C; Bronner, Mary P; Shendure, Jay

    2016-07-01

    Malignant tumors shed DNA into the circulation. The transient half-life of circulating tumor DNA (ctDNA) may afford the opportunity to diagnose, monitor recurrence, and evaluate response to therapy solely through a non-invasive blood draw. However, detecting ctDNA against the normally occurring background of cell-free DNA derived from healthy cells has proven challenging, particularly in non-metastatic solid tumors. In this study, distinct differences in fragment length size between ctDNAs and normal cell-free DNA are defined. Human ctDNA in rat plasma derived from human glioblastoma multiforme stem-like cells in the rat brain and human hepatocellular carcinoma in the rat flank were found to have a shorter principal fragment length than the background rat cell-free DNA (134-144 bp vs. 167 bp, respectively). Subsequently, a similar shift in the fragment length of ctDNA in humans with melanoma and lung cancer was identified compared to healthy controls. Comparison of fragment lengths from cell-free DNA between a melanoma patient and healthy controls found that the BRAF V600E mutant allele occurred more commonly at a shorter fragment length than the fragment length of the wild-type allele (132-145 bp vs. 165 bp, respectively). Moreover, size-selecting for shorter cell-free DNA fragment lengths substantially increased the EGFR T790M mutant allele frequency in human lung cancer. These findings provide compelling evidence that experimental or bioinformatic isolation of a specific subset of fragment lengths from cell-free DNA may improve detection of ctDNA.

  11. Intestinal circulation during inhalation anesthesia

    International Nuclear Information System (INIS)

    Tverskoy, M.; Gelman, S.; Fowler, K.C.; Bradley, E.L.

    1985-01-01

    This study was designed to evaluate the influence of inhalational agents on the intestinal circulation in an isolated loop preparation. Sixty dogs were studied, using three intestinal segments from each dog. Selected intestinal segments were pumped with aortic blood at a constant pressure of 100 mmHg. A mixture of 86 Rb and 9-microns spheres labeled with 141 Ce was injected into the arterial cannula supplying the intestinal loop, while mesenteric venous blood was collected for activity counting. A very strong and significant correlation was found between rubidium clearance and microsphere entrapment (r = 0.97, P less than 0.0001). Nitrous oxide anesthesia was accompanied by a higher vascular resistance (VR), lower flow (F), rubidium clearance (Cl-Rb), and microspheres entrapment (Cl-Sph) than pentobarbital anesthesia, indicating that the vascular bed in the intestinal segment was constricted and flow (total and nutritive) decreased. Halothane, enflurane, and isoflurane anesthesia were accompanied by a much lower arteriovenous oxygen content difference (AVDO 2 ) and oxygen uptake than pentobarbital or nitrous oxide. Compared with pentobarbital, enflurane anesthesia was not accompanied by marked differences in VR, F, Cl-Rb, and Cl-Sph; halothane at 2 MAC decreased VR and increased F and Cl-Rb while isoflurane increased VR and decreased F. alpha-Adrenoceptor blockade with phentolamine (1 mg . kg-1) abolished isoflurane-induced vasoconstriction, suggesting that the increase in VR was mediated via circulating catecholamines

  12. Roadmap for cardiovascular circulation model

    Science.gov (United States)

    Bradley, Christopher P.; Suresh, Vinod; Mithraratne, Kumar; Muller, Alexandre; Ho, Harvey; Ladd, David; Hellevik, Leif R.; Omholt, Stig W.; Chase, J. Geoffrey; Müller, Lucas O.; Watanabe, Sansuke M.; Blanco, Pablo J.; de Bono, Bernard; Hunter, Peter J.

    2016-01-01

    Abstract Computational models of many aspects of the mammalian cardiovascular circulation have been developed. Indeed, along with orthopaedics, this area of physiology is one that has attracted much interest from engineers, presumably because the equations governing blood flow in the vascular system are well understood and can be solved with well‐established numerical techniques. Unfortunately, there have been only a few attempts to create a comprehensive public domain resource for cardiovascular researchers. In this paper we propose a roadmap for developing an open source cardiovascular circulation model. The model should be registered to the musculo‐skeletal system. The computational infrastructure for the cardiovascular model should provide for near real‐time computation of blood flow and pressure in all parts of the body. The model should deal with vascular beds in all tissues, and the computational infrastructure for the model should provide links into CellML models of cell function and tissue function. In this work we review the literature associated with 1D blood flow modelling in the cardiovascular system, discuss model encoding standards, software and a model repository. We then describe the coordinate systems used to define the vascular geometry, derive the equations and discuss the implementation of these coupled equations in the open source computational software OpenCMISS. Finally, some preliminary results are presented and plans outlined for the next steps in the development of the model, the computational software and the graphical user interface for accessing the model. PMID:27506597

  13. Lixiviation of heavy metals of hazardous industrial wastes by means of thermostatized columns and design of a pilot plant; Lixiviacion de metales pesados de residuos industriales peligrosos por medio de columnas termostatizadas y diseno de una planta piloto

    Energy Technology Data Exchange (ETDEWEB)

    Vite T, J.; Leon, C.C. de [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico); Vite T, M.; Soto T, J.L. [IPN, SEPI, ESIME 07738 Mexico D.F. (Mexico)]. e-mail: jvite@nuclear.inin.mx

    2006-07-01

    purpose of this work was to evaluate the efficiency of lixiviation of heavy metals, using thermostatized columns and hazardous industrial residual wastes: those by the volume with which are generated and its high toxicity, its represent a great problem for it treatment and disposition, in this work a diagram of a pilot plant for extraction of heavy metals is included. The process and equipment were patented in United States and in Mexico. For the development of this study four thermostated columns were used that were coupled. The waste were finely milled and suspended in an aqueous pulp adding of 10 - 40gL{sup -1} of mineral acid or sodium hydroxide until reaching an interval of pH of 2,5,7 and 10. Its were used of 4-10 gL{sup -1} of a reducer agent and of 0.3-1.5 g of a surfactant agent. In some cases with this method was possible to remove until 100% of heavy metals. It was used Plasma Emission Spectroscopy to determine the concentrations of the cations in the lixiviation liquors. For studying the metallic alloys the X-ray diffraction technique was used. (Author)

  14. Simulation of Two-Phase Natural Circulation Loop for Core Cather Cooling Using Air Water

    International Nuclear Information System (INIS)

    Revankar, S. T.; Huang, S. F.; Song, K. W.; Rhee, B. W.; Park, R. J.; Song, J. H.

    2012-01-01

    A closed loop natural circulation system employs thermally induced density gradients in single phase or two-phase liquid form to induce circulation of the working fluid thereby obviating the need for any mechanical moving parts such as pumps and pump controls. This increases the reliability and safety of the cooling system and reduces installation, operation and maintenance costs. That is the reason natural circulation cooling has been considered in advanced reactor core cooling and in engineered safety systems. Natural circulation cooling has been proposed to remove reactor decay heat by external vessel cooling for in-vessel core retention during sever accident scenario. Recently in APR1400 reactor core catcher design natural circulation cooling is proposed to stabilize and cool the corium ejected from the reactor vessel following core melt and breach of reactor vessel. The natural circulation flow is similar to external vessel cooling where water flows through an inclined narrow gap below hot surface and is heated to produce boiling. The two-phase natural circulation enables cooling of the corium pool collected on core catcher. Due to importance of this problem this paper focuses simulation of the two-phase natural circulation through inclined gap using air-water system. Scaling criteria for air-water loop are derived that enable simulation of the flow regimes and natural circulation flow rates in such systems using air-water system

  15. Circulating Heat Shock Protein 70 in Health, Aging and Disease

    Directory of Open Access Journals (Sweden)

    Demanet Christian

    2011-03-01

    Full Text Available Abstract Background Heat shock proteins (Hsp are ubiquitously synthesised in virtually all species and it is hypothesised that they might have beneficial health effects. Recent studies have identified circulating Hsp as an important mediator in inflammation - the effects of low-grade inflammation in the aging process are overwhelming. While much is known about intracellular Hsp70, scant data exist on circulating Hsp70 in the aging context. Therefore, the objectives of this study were to investigate the effect of age and disease on circulating Hsp70 and, in particular, to evaluate the association between circulating Hsp70 and inflammatory parameters. Results Serum Hsp70, Interleukin (IL -10, IL-6 and Tumor Necrosis Factor (TNF alpha concentrations were determined in 90 hospitalised geriatric patients (aged 83 ± 6 years and in 200 community-dwelling control subjects (100 elderly, aged 74 ± 5 years, and 100 young, aged 23 ± 3 years. In the community-dwelling elderly, serum Hsp70 and IL-10 concentrations were significantly lower and IL-6 was significantly higher when compared to healthy young control subjects. Elderly patients presenting inflammation (CRP serum levels ≥5 mg/L showed significantly (p = 0.007 higher Hsp70 values; and Hsp70 correlated positively (p Conclusions The present data provide new evidence that serum concentration of Hsp70 decreases with age in a normal population. Our study also shows that higher levels of Hsp70 are associated with inflammation and frailty in elderly patients.

  16. Uranus atmospheric dynamics and circulation

    Science.gov (United States)

    Allison, Michael; Beebe, Reta F.; Conrath, Barney J.; Hinson, David P.; Ingersoll, Andrew P.

    1991-01-01

    The observations, models, and theories relevant to the atmospheric dynamics and meteorology of Uranus are discussed. The available models for the large-scale heat transport and atmospheric dynamics as well as diagnostic interpretations of the Voyager data are reviewed. Some pertinent ideas and questions regarding the global circulation balance are considered, partly in comparison with other planetary atmospheres. The available data indicate atmospheric rotation at midlatitudes nearly 200 m/s faster than that of the planetary magnetic field. Analysis of the dynamical deformation of the shape and size of isobaric surfaces measured by the Voyager radio-occultation experiment suggests a subrotating equator at comparable altitudes. Infrared temperature retrievals above the cloud deck indicate a smaller equator-to-pole contrast than expected for purely radiative-convective equilibrium, but show local variations implying a latitudinally correlated decrease with altitude in the cloud-tracked wind.

  17. Improvement of Classification of Enterprise Circulating Funds

    Directory of Open Access Journals (Sweden)

    Rohanova Hanna O.

    2014-02-01

    Full Text Available The goal of the article lies in revelation of possibilities of increase of efficiency of managing enterprise circulating funds by means of improvement of their classification features. Having analysed approaches of many economists to classification of enterprise circulating funds, systemised and supplementing them, the article offers grouping classification features of enterprise circulating funds. In the result of the study the article offers an expanded classification of circulating funds, which clearly shows the role of circulating funds in managing enterprise finance and economy in general. The article supplements and groups classification features of enterprise circulating funds by: the organisation level, functioning character, sources of formation and their cost, and level of management efficiency. The article shows that the provided grouping of classification features of circulating funds allows exerting all-sided and purposeful influence upon indicators of efficiency of circulating funds functioning and facilitates their rational management in general. The prospect of further studies in this direction is identification of the level of attraction of loan resources by production enterprises for financing circulating funds.

  18. NPP Krsko natural circulation performance evaluation

    International Nuclear Information System (INIS)

    Segon, Velimir; Bajs, Tomislav; Frogheri, Monica

    1999-01-01

    The present document deals with an evaluation of the natural circulation performance of the Krsko nuclear power plant. Two calculation have been performed using the NPP Krsko nodalization (both similar to the LOBI A2-77 natural circulation experiment) - the first with the present steam generators at NPP Krsko (Westinghouse, 18% plugged), the second with the future steam generators (Siemens, 0% plugged). The results were evaluated using the natural circulation flow map derived in /1/, and were compared to evaluate the influence of the new steam generators on the natural circulation performance. (author)

  19. A blood circulation model for reference man

    Energy Technology Data Exchange (ETDEWEB)

    Leggett, R.W.; Eckerman, K.F. [Oak Ridge National Lab., TN (United States); Williams, L.R. [Indiana Univ., South Bend, IN (United States). Div. of Liberal Arts and Sciences

    1996-12-31

    A dynamic blood circulation model that predicts the movement and gradual dispersion of a bolus of material in the circulation after its intravenous injection into an adult human. The main purpose of the model is improve the dosimetry of internally deposited radionuclides that decay in the circulation to a significant extent. The model partitions the blood volume into 24 separate organs or tissues, right heart chamber, left heart chamber, pulmonary circulation, arterial outflow to the aorta and large arteries, and venous return via the large veins. Model results were compared to data obtained from injection of carbon 11 labeled carbon monoxide or rubidium 86.

  20. A blood circulation model for reference man

    International Nuclear Information System (INIS)

    Leggett, R.W.; Eckerman, K.F.; Williams, L.R.

    1996-01-01

    A dynamic blood circulation model that predicts the movement and gradual dispersion of a bolus of material in the circulation after its intravenous injection into an adult human. The main purpose of the model is improve the dosimetry of internally deposited radionuclides that decay in the circulation to a significant extent. The model partitions the blood volume into 24 separate organs or tissues, right heart chamber, left heart chamber, pulmonary circulation, arterial outflow to the aorta and large arteries, and venous return via the large veins. Model results were compared to data obtained from injection of carbon 11 labeled carbon monoxide or rubidium 86

  1. Basic natural circulation characteristics of SBWR

    International Nuclear Information System (INIS)

    Kuran, S.; Soekmen, C. N.

    2001-01-01

    Natural circulation is an important passive heat removal mechanism for both existing and next generation light water reactors. Simplified Boiling Water Reactor (SBWR) is one of the advanced light water reactors that rely on natural circulation for normal as well as emergency core cooling. In this study, basic natural circulation characteristics of this reactor are examined on a flow loop that simulates the operation of SBWR. On this model, effect of system operating parameters on the steady state natural circulation characteristics inside the loop is studied via solving the transcendental equation for loop flow rate

  2. The Dynamics of Hadley Circulation Variability and Change

    Science.gov (United States)

    Davis, Nicholas Alexander

    The Hadley circulation exerts a dominant control on the surface climate of earth's tropical belt. Its converging surface winds fuel the tropical rains, while subsidence in the subtropics dries and stabilizes the atmosphere, creating deserts on land and stratocumulus decks over the oceans. Because of the strong meridional gradients in temperature and precipitation in the subtropics, any shift in the Hadley circulation edge could project as major changes in surface climate. While climate model simulations predict an expansion of the Hadley cells in response to greenhouse gas forcings, the mechanisms remain elusive. An analysis of the climatology, variability, and response of the Hadley circulation to radiative forcings in climate models and reanalyses illuminates the broader landscape in which Hadley cell expansion is realized. The expansion is a fundamental response of the atmosphere to increasing greenhouse gas concentrations as it scales with other key climate system changes, including polar amplification, increasing static stability, stratospheric cooling, and increasing global-mean surface temperatures. Multiple measures of the Hadley circulation edge latitudes co-vary with the latitudes of the eddy-driven jets on all timescales, and both exhibit a robust poleward shift in response to forcings. Further, across models there is a robust coupling between the eddy-driving on the Hadley cells and their width. On the other hand, the subtropical jet and tropopause break latitudes, two common observational proxies for the tropical belt edges, lack a strong statistical relationship with the Hadley cell edges and have no coherent response to forcings. This undermines theories for the Hadley cell width predicated on angular momentum conservation and calls for a new framework for understanding Hadley cell expansion. A numerical framework is developed within an idealized general circulation model to isolate the mean flow and eddy responses of the global atmosphere to

  3. Functional evaluation of circulating hematopoietic progenitors in Noonan syndrome

    Science.gov (United States)

    TIMEUS, FABIO; CRESCENZIO, NICOLETTA; BALDASSARRE, GIUSEPPINA; DORIA, ALESSANDRA; VALLERO, STEFANO; FOGLIA, LUISELDA; PAGLIANO, SARA; ROSSI, CESARE; SILENGO, MARGHERITA CIRILLO; RAMENGHI, UGO; FAGIOLI, FRANCA; DI MONTEZEMOLO, LUCA CORDERO; FERRERO, GIOVANNI BATTISTA

    2013-01-01

    comparison with the controls (median, 8.6%; range, 0–27.7% vs. median, 17.6%; range, 2.8–49.6%), suggesting an increased CD34+ cell survival. The functional evaluation of circulating hematopoietic progenitors showed specific patterns in NS and NS/MPD. These tests are a reliable integrative tool that, together with clinical data and other hematological parameters, could help detect NS patients with a high risk for a myeloproliferative evolution. PMID:23756559

  4. Total kinetic energy in four global eddying ocean circulation models and over 5000 current meter records

    KAUST Repository

    Scott, Robert B.; Arbic, Brian K.; Chassignet, Eric P.; Coward, Andrew C.; Maltrud, Mathew; Merryfield, William J.; Srinivasan, Ashwanth; Varghese, Anson

    2010-01-01

    We compare the total kinetic energy (TKE) in four global eddying ocean circulation simulations with a global dataset of over 5000, quality controlled, moored current meter records. At individual mooring sites, there was considerable scatter between

  5. Distinct features of circulating microparticles and their relationship to clinical manifestations in systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Nielsen, Christoffer T; Østergaard, Ole; Johnsen, Christina

    2011-01-01

    Characterization of the abundance, origin, and annexin V (AnxV)-binding capabilities of circulating microparticles (MPs) in SLE patients and healthy controls and to determine any associations with clinical parameters....

  6. Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC).

    Science.gov (United States)

    Dossus, Laure; McKay, James D; Canzian, Federico; Wilkening, Stefan; Rinaldi, Sabina; Biessy, Carine; Olsen, Anja; Tjønneland, Anne; Jakobsen, Marianne U; Overvad, Kim; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie-Christine; Fournier, Agnes; Linseisen, Jakob; Lukanova, Annekatrin; Boeing, Heiner; Fisher, Eva; Trichopoulou, Antonia; Georgila, Christina; Trichopoulos, Dimitrios; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Vineis, Paolo; Quirós, José Ramon; Sala, Núria; Martínez-García, Carmen; Dorronsoro, Miren; Chirlaque, Maria-Dolores; Barricarte, Aurelio; van Duijnhoven, Fränzel J B; Bueno-de-Mesquita, H B; van Gils, Carla H; Peeters, Petra H M; Hallmans, Göran; Lenner, Per; Bingham, Sheila; Khaw, Kay Tee; Key, Tim J; Travis, Ruth C; Ferrari, Pietro; Jenab, Mazda; Riboli, Elio; Kaaks, Rudolf

    2008-07-01

    Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also suggests a role of ghrelin in cancer development. We conducted a case-control study on 1359 breast cancer cases and 2389 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition, to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with anthropometric measures, circulating insulin growth factor I (IGF-I) and insulin-like growth factor-binding protein 3 and breast cancer risk. Pair-wise tagging was used to select the 15 polymorphisms that represent the majority of common genetic variants across the GHRL and GHSR genes. A significant increase in breast cancer risk was observed in carriers of the GHRL rs171407-G allele (odds ratio: 1.2; 95% confidence interval: 1.0-1.4; P = 0.02). The GHRL single-nucleotide polymorphism rs375577 was associated with a 5% increase in IGF-I levels (P = 0.01). A number of GHRL and GHSR polymorphisms were associated with body mass index (BMI) and height (P between GHRL variations are associated with BMI. Furthermore, we have observed evidence for association of GHRL polymorphisms with circulating IGF-I levels and with breast cancer risk. These associations, however, might also be due to chance findings and further large studies are needed to confirm our results.

  7. Circulating Immune Complexes among Diabetic Children

    Directory of Open Access Journals (Sweden)

    George Nicoloff

    2004-01-01

    Full Text Available Insulin dependent diabetes mellitus (IDDM is an autoimmune disease associated with the presence of different types of autoantibodies. The presence of these antibodies and the corresponding antigens in the circulation leads to the formation of circulating immune complexes (CIC. CIC are known to persist in the blood for long periods of time. Such CIC following deposition in the small blood vessels have the potential to lead to microangiopathy with debilitating clinical consequences. The aim of our pilot study was to investigate whether a correlation exists between CIC and the development of microvascular complications in diabetic children. Isolation of a new glycoprotein complement inhibition factor (CIF from the parasitic plant Cuscuta europea seed, which appears to bind specifically to complement component C3 has provided an unique tool for the measurement of immune complexes by means of ELISA-type techniques (CIF-ELISA. We studied the levels of CIC (IgG, IgM and IgA in 58 diabetic children (mean age 12.28±4.04 years, diabetes duration 5.3±3.7 years, 29 of them had vascular complications (group 1 and the other 29 were without vascular complications (group 2. As controls, we studied sera samples from 21 healthy children (mean age 13.54±4.03 years. Sera from the diabetic patients showed statistically significant higher levels of CIC IgG ( p=0.03 than sera from the control group. In sera from group 1 values of CIC IgG showed statistically significant higher levels than controls (0.720±0.31 vs. 0.46±0.045; p=0.011 Sera from 59% of the patients were positive for CIC IgG, 36% for CIC IgM and 9% for CIC IgA. Among 26 patients with microalbuminuria, sera from 17/26 (65% were positive for CIC IgG, 8/26 (31% for CIC IgM and 2/26 (8% for CIC IgA. CIC IgG correlated with HbA1c (r=0.51; p=0.005 and microalbuminuria (r=0.42, p=0.033. CIC IgA correlated with age (r=0.44, p=0.03. CIC IgM correlated with the duration of diabetes (r=0.63, p=0.02. These

  8. Natural circulation in reactor coolant system

    International Nuclear Information System (INIS)

    Han, J.T.

    1987-01-01

    Reactor coolant system (RCS) natural circulation in a PWR is the buoyancy-driven coolant circulation between the core and the upper-plenum region (in-vessel circulation) with or without a countercurrent flow in the hot leg piping between the vessel and steam generators (ex-vessel circulation). This kind of multidimensional bouyancy-driven flow circulation serves as a means of transferring the heat from the core to the structures in the upper plenum, hot legs, and possibly steam generators. As a result, the RCS piping and other pressure boundaries may be heated to high temperatures at which the structural integrity is challenged. RCS natural circulation is likely to occur during the core uncovery period of the TMLB' accident in a PWR when the vessel upper plenum and hot leg are already drained and filled with steam and possibly other gaseous species. RCS natural circulation is being studied for the Surry plant during the TMLB' accident in which station blackout coincides with the loss of auxiliary feedwater and no operator actions. The effects of the multidimensional RCS natural circulation during the TMLB' accident are discussed

  9. Circulating follistatin in relation to energy metabolism

    DEFF Research Database (Denmark)

    Hansen, Jakob Schiøler; Plomgaard, Peter

    2016-01-01

    a relation to energy metabolism. In this narrative review, we attempt to reconcile the existing findings on circulating follistatin with the novel concept that circulating follistatin is a liver-derived molecule regulated by the glucagon-to-insulin ratio. The picture emerging is that conditions associated...

  10. Information and Communications Systems for Control-by-Price of Distributed Energy Resources and Flexible Demand

    DEFF Research Database (Denmark)

    Nyeng, Preben; Østergaard, Jacob

    2011-01-01

    infrastructure and subsystem design and secondly focus on the design and implementation of the end-user price-responsive controller, interfaces, and communications. The design and its applicability on existing devices is verified through laboratory tests with two cases: electric space heating thermostat control...... and a small combined heat and power unit. The results show that the price-responsive controller reduces the end user’s electricity cost, or increases his income respectively, by about 7%. At the same time, the price-responsive controller provides an interface for the transmission system operator to utilize...

  11. Benchmark analysis of three main circulation pump sequential trip event at Ignalina NPP

    International Nuclear Information System (INIS)

    Uspuras, E.; Kaliatka, A.; Urbonas, R.

    2001-01-01

    The Ignalina Nuclear Power Plant is a twin-unit with two RBMK-1500 reactors. The primary circuit consists of two symmetrical loops. Eight Main Circulation Pumps (MCPs) at the Ignalina NPP are employed for the coolant water forced circulation through the reactor core. The MCPs are joined in groups of four pumps for each loop (three for normal operation and one on standby). This paper presents the benchmark analysis of three main circulation pump sequential trip event at RBMK-1500 using RELAP5 code. During this event all three MCPs in one circulation loop at Unit 2 Ignalina NPP were tripped one after another, because of inadvertent activation of the fire protection system. The comparison of calculated and measured parameters led us to establish realistic thermal hydraulic characteristics of different main circulation circuit components and to verify the model of drum separators pressure and water level controllers.(author)

  12. The role of natural circulation in the FFTF [Fast Flux Test Facility] passive safety tests

    International Nuclear Information System (INIS)

    Stover, R.L.; Padilla, A.; Burke, T.M.; Knecht, W.L.

    1987-03-01

    A series of tests were completed at the Fast Flux Test Facility to demonstrate the passive safety characteristics of liquid metal reactors with natural circulation flow. The first test consisted of transition from forced to natural circulation flow at an initial decay power of 0.3%. The second test represented an unprotected loss-of-flow transient to natural circulation from 50% power with the control rods prevented from scramming into the core. The third test was a steady-state, natural circulation condition with core fission powers up ato about 2.3%. Core sodium data and results of single and multi-channel computer models confirmed the reliability and effectiveness of natural circulation flow for liquid metal reactor safety

  13. Circulating Zinc-α2-glycoprotein levels and Insulin Resistance in Polycystic Ovary Syndrome

    Science.gov (United States)

    Lai, Yerui; Chen, Jinhua; Li, Ling; Yin, Jingxia; He, Junying; Yang, Mengliu; Jia, Yanjun; Liu, Dongfang; Liu, Hua; Liao, Yong; Yang, Gangyi

    2016-01-01

    The aim of study was to assess the relationship between zinc-α2-glycoprotein (ZAG) and androgen excess with insulin resistance in polycystic ovary syndrome (PCOS) women. 99 PCOS women and 100 healthy controls were recruited. Euglycemic-hyperinsulinemic clamp (EHC) was preformed to assess their insulin sensitivity. Circulating ZAG was determined with an ELISA kit. In healthy subjects, circulating ZAG levels exhibited a characteristic diurnal rhythm in humans, with a major nocturnal rise occurring between midnight and early morning. Circulating ZAG and M-value were much lower in PCOS women than in the controls. In all population, overweight/obese subjects had significantly lower circulating ZAG levels than lean individuals. Multiple linear regression analysis revealed that only M-value and the area under the curve for glucose were independently related factors to circulating ZAG in PCOS women. Multivariate logistic regression analysis showed that circulating ZAG was significantly associated with PCOS even after controlling for anthropometric variables, blood pressure, lipid profile and hormone levels. The PCOS women with high ZAG had fewer MetS, IGT and polycystic ovaries as compared with the low ZAG PCOS women. Taken together, circulating ZAG levels are reduced in women with PCOS and ZAG may be a cytokine associated with insulin resistance in PCOS women. PMID:27180914

  14. Moderator circulation in CANDU reactors

    International Nuclear Information System (INIS)

    Fath, H.E.S.; Hussein, M.A.

    1989-01-01

    A two-dimensional computer code that is capable of predicting the moderator flow and temperature distribution inside CANDU calandria is presented. The code uses a new approach to simulate the calandria tube matrix by blocking the cells containing the tubes in the finite difference mesh. A jet momentum-dominant flow pattern is predicted in the nonisothermal case, and the effect of the buoyancy force, resulting from nuclear heating, is found to enhance the speed of circulation. Hot spots are located in low-velocity areas at the top of the calandria and below the inlet jet level between the fuel channels. A parametric study is carried out to investigate the effect of moderator inlet velocity,moderator inlet nozzle location, and geometric scaling. The results indicate that decreasing the moderator inlet velocity has no significant influence on the general features of the flow pattern (i.e., momentum dominant); however, too many high-temperature hot spots appear within the fuel channels

  15. Numerical Modeling of Ocean Circulation

    Science.gov (United States)

    Miller, Robert N.

    2007-01-01

    The modelling of ocean circulation is important not only for its own sake, but also in terms of the prediction of weather patterns and the effects of climate change. This book introduces the basic computational techniques necessary for all models of the ocean and atmosphere, and the conditions they must satisfy. It describes the workings of ocean models, the problems that must be solved in their construction, and how to evaluate computational results. Major emphasis is placed on examining ocean models critically, and determining what they do well and what they do poorly. Numerical analysis is introduced as needed, and exercises are included to illustrate major points. Developed from notes for a course taught in physical oceanography at the College of Oceanic and Atmospheric Sciences at Oregon State University, this book is ideal for graduate students of oceanography, geophysics, climatology and atmospheric science, and researchers in oceanography and atmospheric science. Features examples and critical examination of ocean modelling and results Demonstrates the strengths and weaknesses of different approaches Includes exercises to illustrate major points and supplement mathematical and physical details

  16. Circulating microparticles: square the circle

    Science.gov (United States)

    2013-01-01

    Background The present review summarizes current knowledge about microparticles (MPs) and provides a systematic overview of last 20 years of research on circulating MPs, with particular focus on their clinical relevance. Results MPs are a heterogeneous population of cell-derived vesicles, with sizes ranging between 50 and 1000 nm. MPs are capable of transferring peptides, proteins, lipid components, microRNA, mRNA, and DNA from one cell to another without direct cell-to-cell contact. Growing evidence suggests that MPs present in peripheral blood and body fluids contribute to the development and progression of cancer, and are of pathophysiological relevance for autoimmune, inflammatory, infectious, cardiovascular, hematological, and other diseases. MPs have large diagnostic potential as biomarkers; however, due to current technological limitations in purification of MPs and an absence of standardized methods of MP detection, challenges remain in validating the potential of MPs as a non-invasive and early diagnostic platform. Conclusions Improvements in the effective deciphering of MP molecular signatures will be critical not only for diagnostics, but also for the evaluation of treatment regimens and predicting disease outcomes. PMID:23607880

  17. Vertical mixing by Langmuir circulations

    International Nuclear Information System (INIS)

    McWilliams, James C.; Sullivan, Peter P.

    2001-01-01

    Wind and surface wave frequently induce Langmuir circulations (LC) in the upper ocean, and the LC contribute to mixing materials down from the surface. In this paper we analyze large-eddy simulation (LES) cases based on surface-wave-averaged, dynamical equations and show that the effect of the LC is a great increase in the vertical mixing efficiency for both material properties and momentum. We provide new confirmation that the previously proposed K-profile parameterization (KPP) model accurately characterizes the turbulent transport in a weakly convective, wind-driven boundary layer with stable interior stratification. We also propose a modest generalization of KPP for the regime of weakly convective Langmuir turbulence. This makes the KPP turbulent flux profiles match those in the LES case with LC present fairly well, especially so for material properties being transported downwards from the ocean surface. However, some open issues remain about how well the present LES and KPP formulations represent Langmuir turbulence, in part because wave-breaking effects are not yet included. (Author)

  18. Circulating 25-Hydroxyvitamin D and Risk of Pancreatic Cancer

    OpenAIRE

    Stolzenberg-Solomon, Rachael Z.; Jacobs, Eric J.; Arslan, Alan A.; Qi, Dai; Patel, Alpa V.; Helzlsouer, Kathy J.; Weinstein, Stephanie J.; McCullough, Marjorie L.; Purdue, Mark P.; Shu, Xiao-Ou; Snyder, Kirk; Virtamo, Jarmo; Wilkins, Lynn R.; Yu, Kai; Zeleniuch-Jacquotte, Anne

    2010-01-01

    Results from epidemiologic studies examining pancreatic cancer risk and vitamin D intake or 25-hydroxyvitamin D (25(OH)D) concentrations (the best indicator of vitamin D derived from diet and sun) have been inconsistent. Therefore, the authors conducted a pooled nested case-control study of participants from 8 cohorts within the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP) (1974?2006) to evaluate whether prediagnostic circulating 25(OH)D concentrations were associated w...

  19. Measurement of Circulating Cytokines and Immune-Activation Markers by Multiplex Technology in the Clinical Setting: What Are We Really Measuring?

    Science.gov (United States)

    Aziz, Najib

    2015-01-01

    Measurement of circulating cytokine levels can provide important information in the study of the pathogenesis of disease. John L. Fahey was a pioneer in the measurement of circulating cytokines and immune-activation markers and a leader in the quality assessment/control of assays for measurement of circulating cytokines. Insights into the measurement of circulating cytokines, including consideration of multiplex assays, are presented here.

  20. 46 CFR 56.50-45 - Circulating pumps.

    Science.gov (United States)

    2010-10-01

    ... APPURTENANCES Design Requirements Pertaining to Specific Systems § 56.50-45 Circulating pumps. (a) A main circulating pump and emergency means for circulating water through the main condenser shall be provided. The... circulating pump and the condenser. (b) Independent sea suctions shall be provided for the main circulating...

  1. Air Circulation and Heat Exchange under Reduced Pressures

    Science.gov (United States)

    Rygalov, Vadim; Wheeler, Raymond; Dixon, Mike; Hillhouse, Len; Fowler, Philip

    Low pressure atmospheres were suggested for Space Greenhouses (SG) design to minimize sys-tem construction and re-supply materials, as well as system manufacturing and deployment costs. But rarified atmospheres modify heat exchange mechanisms what finally leads to alter-ations in thermal control for low pressure closed environments. Under low atmospheric pressures (e.g., lower than 25 kPa compare to 101.3 kPa for normal Earth atmosphere), convection is becoming replaced by diffusion and rate of heat exchange reduces significantly. During a period from 2001 to 2009, a series of hypobaric experiments were conducted at Space Life Sciences Lab (SLSLab) NASA's Kennedy Space Center and the Department of Space Studies, University of North Dakota. Findings from these experiments showed: -air circulation rate decreases non-linearly with lowering of total atmospheric pressure; -heat exchange slows down with pressure decrease creating risk of thermal stress (elevated leaf tem-peratures) for plants in closed environments; -low pressure-induced thermal stress could be reduced by either lowering system temperature set point or increasing forced convection rates (circulation fan power) within certain limits; Air circulation is an important constituent of controlled environments and plays crucial role in material and heat exchange. Theoretical schematics and mathematical models are developed from a series of observations. These models can be used to establish optimal control algorithms for low pressure environments, such as a space greenhouse, as well as assist in fundamental design concept developments for these or similar habitable structures.

  2. Circulating microRNAs in breast cancer

    DEFF Research Database (Denmark)

    Hamam, Rimi; Hamam, Dana; Alsaleh, Khalid A.

    2017-01-01

    Effective management of breast cancer depends on early diagnosis and proper monitoring of patients' response to therapy. However, these goals are difficult to achieve because of the lack of sensitive and specific biomarkers for early detection and for disease monitoring. Accumulating evidence...... in the past several years has highlighted the potential use of peripheral blood circulating nucleic acids such as DNA, mRNA and micro (mi)RNA in breast cancer diagnosis, prognosis and for monitoring response to anticancer therapy. Among these, circulating miRNA is increasingly recognized as a promising...... circulating miRNAs as diagnostic, prognostic or predictive biomarkers in breast cancer management....

  3. Performance Improvement of a Radioactive Forced Circulation Evaporator System

    International Nuclear Information System (INIS)

    Zaki, A.A.; Hala, A.A.; Othman, E.A.

    2016-01-01

    Evaporation is a proven method for treatment of liquid radioactive wastes providing both good decontamination and high concentration. In a radioactive waste treatment plant a forced circulation evaporator is used to reduce the volume of radioactive liquid wastes arising from different applications of nuclear industries. The safe operation, limiting the composition of the liquid radioactive waste at a prescribed value, with high performance efficiency, requires good control for the evaporator operating pressure and the level of liquid waste inside the separator part of the evaporator. The aim of this work was to improve the safety and performance of a forced-circulation evaporator used in a liquid radioactive wastes treatment plant. In this respect, a level controller system for this type of evaporator was designed, where proportional (P), proportional Integral (PI) and deadbeat response controllers for the separator level system were suggested. More over, an ideal 2×2(2 inputs and 2 outputs )de coupler controller for controlling the operating pressure and the product composition was developed. Computer results demonstrated that the deadbeat response has been success fully obtained from the developed separator control system. The maximum over shoot in the unit-step response curve was reduce d to 25 % and the settling time also was reduced to more than the half; about 26 minutes using Ziegler-Nichols tuning technique.The designed de coupling controller has been found effective in achieving a good trade-off between stability and performance

  4. Regulation of leucocyte homeostasis in the circulation.

    Science.gov (United States)

    Scheiermann, Christoph; Frenette, Paul S; Hidalgo, Andrés

    2015-08-01

    The functions of blood cells extend well beyond the immune functions of leucocytes or the respiratory and hemostatic functions of erythrocytes and platelets. Seen as a whole, the bloodstream is in charge of nurturing and protecting all organs by carrying a mixture of cell populations in transit from one organ to another. To optimize these functions, evolution has provided blood and the vascular system that carries it with various mechanisms that ensure the appropriate influx and egress of cells into and from the circulation where and when needed. How this homeostatic control of blood is achieved has been the object of study for over a century, and although the major mechanisms that govern it are now fairly well understood, several new concepts and mediators have recently emerged that emphasize the dynamism of this liquid tissue. Here we review old and new concepts that relate to the maintenance and regulation of leucocyte homeostasis in blood and briefly discuss the mechanisms for platelets and red blood cells. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.

  5. Methods of quantifying circulating IgE

    International Nuclear Information System (INIS)

    Merrett, T.G.; Merrett, J.

    1978-01-01

    Four radioimmunoassay techniques, two conventional and two sandwich, have been used to measure circulating IgE levels in 100 sera. The test sera had IgE levels ranging from 1.0 to 20,000 u/ml, and each was measured at five dilutions, ranging from three-fold to 400-fold. The same IgE standards were used throughout, and the optimal range for each assay was determined by assessing data for quality control sera and the WHO standard 69/204. To be of general use in the United Kingdom an IgE test must measure accurately levels as low as 20-30 u IgE/ml. The Phadebas RIST method failed to meet this criterion, and of the remaining tests the double antibody method had the most useful operating range and produced the most reliable results. However, the double antibody method is not available commercially and so, for the majority of laboratories, the Phadebas PRIST technique should be the method chosen. (author)

  6. Influence of reactor design on the establishment of natural circulation in pool-type LMFBR

    International Nuclear Information System (INIS)

    Durham, M.E.

    1976-01-01

    The general principles involved in establishing natural circulation in a pool-type liquid metal cooled fast breeder reactor following loss of a.c. supplies are elucidated and the effects of design features by use of the computer code MELANI are quantified. It is shown that natural circulation can provide a feasible means of emergency core cooling in addition to that provided by pony motors. The choice of primary pump rundown time has a significant effect in controlling peak core outlet temperatures in the hypothetical case of natural circulation alone being the core heat removal process. (author)

  7. Culture and Characterization of Circulating Endothelial Progenitor Cells in Patients with Renal Cell Carcinoma.

    Science.gov (United States)

    Gu, Wenyu; Sun, Wei; Guo, Changcheng; Yan, Yang; Liu, Min; Yao, Xudong; Yang, Bin; Zheng, Junhua

    2015-07-01

    Although emerging evidence demonstrates increased circulating endothelial progenitor cells in patients with solid tumors, to our knowledge it is still unknown whether such cells can be cultured from patients with highly angiogenic renal cell carcinoma. We cultured and characterized circulating endothelial progenitor cells from patients with renal cell carcinoma. The circulating endothelial progenitor cell level (percent of CD45(-)CD34(+) VEGF-R2(+) cells in total peripheral blood mononuclear cells) was quantified in 47 patients with renal cell carcinoma and 40 healthy controls. Peripheral blood mononuclear cells were then isolated from 33 patients with renal cell carcinoma and 30 healthy controls to culture and characterize circulating endothelial progenitor cells. The circulating endothelial progenitor cell level was significantly higher in patients with renal cell carcinoma than in healthy controls (0.276% vs 0.086%, p cells first emerged significantly earlier in patient than in control preparations (6.72 vs 14.67 days, p culture success rate (87.8% vs 40.0% of participants) and the number of colonies (10.06 vs 1.83) were significantly greater for patients than for controls (each p cell level correlated positively with the number of patient colonies (r = 0.762, p Cells cultured from patients and controls showed a similar growth pattern, immunophenotype, ability to uptake Ac-LDL and bind lectin, and form capillary tubes in vitro. However, significantly more VEGF-R2(+) circulating endothelial progenitor cells were found in preparations from patients with renal cell carcinoma than from healthy controls (21.1% vs 13.4%, p cell colonies, a higher cell culture success rate and more colonies were found for patients with renal cell carcinoma than for healthy controls. Results indicate the important significance of VEGF-R2(+) circulating endothelial progenitors in patients with renal cell carcinoma. Copyright © 2015 American Urological Association Education and Research

  8. Main circulator design features for HTR 100, HTR 500 and space heating plants

    International Nuclear Information System (INIS)

    Engel, J.; Glass, D.

    1988-01-01

    All design alternatives for modern high-temperature reactors have a common circulator concept: It is based on a vertical shaft design with a flying impeller. The circulators are equipped with active magnetic bearings and are driven by induction motors connected to variable-speed static converters. Due to their multiple functions during normal reactor operation and under accident conditions, extremely high requirements are made to safety-relevant circulators, since with the reactor pressurized as well as under depressurized conditions specified delivery heads and flow rates have to be ensured. The use of active magnetic bearings permits to obtain maintenance-free operation and functional safety to an extent which had not been achieved before. Magnetic bearings are therefore provided for the total range including primary gas circulators of a drive power of several MW as well as circulators for helium loops of reactor auxiliary systems. The essential feature for using active magnetic bearings is the retainer bearing technology, preventing contact between rotor and static circulator parts upon unintended deenergisation of the magnets. Results of current experiments are reported. Another aspect to be considered for reliable long-term operation for several decades is the effect of rotor dynamics. The various natural frequencies resulting from torsion and bending modes in view of a drive by a frequency-controlled induction motor have to be considered as well as the specific characteristics of the active magnetic bearings. Special attention has to be directed to the internal cooling loop so as to ensure that reactor temperature excursions in the event of deviation from normal operation can be overcome without damage. For circulator components exposed to temperature fields the design characteristics are determined by combining experimental and analytical methods. The coordination of all component parts is currently being optimized on a prototype circulator whose detailed

  9. Equivalent Circulation Density Analysis of Geothermal Well by Coupling Temperature

    Directory of Open Access Journals (Sweden)

    Xiuhua Zheng

    2017-02-01

    Full Text Available The accurate control of the wellbore pressure not only prevents lost circulation/blowout and fracturing formation by managing the density of the drilling fluid, but also improves productivity by mitigating reservoir damage. Calculating the geothermal pressure of a geothermal well by constant parameters would easily bring big errors, as the changes of physical, rheological and thermal properties of drilling fluids with temperature are neglected. This paper researched the wellbore pressure coupling by calculating the temperature distribution with the existing model, fitting the rule of density of the drilling fluid with the temperature and establishing mathematical models to simulate the wellbore pressures, which are expressed as the variation of Equivalent Circulating Density (ECD under different conditions. With this method, the temperature and ECDs in the wellbore of the first medium-deep geothermal well, ZK212 Yangyi Geothermal Field in Tibet, were determined, and the sensitivity analysis was simulated by assumed parameters, i.e., the circulating time, flow rate, geothermal gradient, diameters of the wellbore, rheological models and regimes. The results indicated that the geothermal gradient and flow rate were the most influential parameters on the temperature and ECD distribution, and additives added in the drilling fluid should be added carefully as they change the properties of the drilling fluid and induce the redistribution of temperature. To ensure the safe drilling and velocity of pipes tripping into the hole, the depth and diameter of the wellbore are considered to control the surge pressure.

  10. Seawater circulating system in an aquaculture laboratory

    Digital Repository Service at National Institute of Oceanography (India)

    Chatterji, A.; Ingole, B.S.; Parulekar, A.H.

    The note gives an account, for the first time in India, of an Aquaculture Laboratory with open type seawater circulating system developed at the National Institute of Oceanography, Goa, India. Besides describing the details of the system...

  11. EOP MIT General Circulation Model (MITgcm)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data contains a regional implementation of the Massachusetts Institute of Technology general circulation model (MITgcm) at a 1-km spatial resolution for the...

  12. Seasonal Overturning Circulation in the Red Sea

    Science.gov (United States)

    Yao, F.; Hoteit, I.; Koehl, A.

    2010-12-01

    The Red Sea exhibits a distinct seasonal overturning circulation. In winter, a typical two-layer exchange structure, with a fresher inflow from the Gulf of Aden on top of an outflow from the Red Sea, is established. In summer months (June to September) this circulation pattern is changed to a three-layer structure: a surface outflow from the Red Sea on top of a subsurface intrusion of the Gulf of Aden Intermediate Water and a weakened deep outflow. This seasonal variability is studied using a general circulation model, MITgcm, with 6 hourly NCEP atmospheric forcing. The model is able to reproduce the observed seasonal variability very well. The forcing mechanisms of the seasonal variability related to seasonal surface wind stress and buoyancy flux, and water mass transformation processes associated with the seasonal overturning circulation are analyzed and presented.

  13. Blocking device especially for circulating pumps

    International Nuclear Information System (INIS)

    Susil, J.; Vychodil, V.; Lorenc, P.

    1976-01-01

    The claim of the invention is a blocking device which blocks reverse flow occurring after the shutdown of circulating pumps, namely in the operation of nuclear power plants or in pumps with a high delivery head. (F.M.)

  14. [Circulating endothelial progenitor cell levels in treated hypertensive patients].

    Science.gov (United States)

    Maroun-Eid, C; Ortega-Hernández, A; Abad, M; García-Donaire, J A; Barbero, A; Reinares, L; Martell-Claros, N; Gómez-Garre, D

    2015-01-01

    Most optimally treated hypertensive patients still have an around 50% increased risk of any cardiovascular event, suggesting the possible existence of unidentified risk factors. In the last years there has been evidence of the essential role of circulating endothelial progenitor cells (EPCs) in the maintenance of endothelial integrity and function, increasing the interest in their involvement in cardiovascular disease. In this study, the circulating levels of EPCs and vascular endothelial growth factor (VEGF) are investigated in treated hypertensive patients with adequate control of blood pressure (BP). Blood samples were collected from treated hypertensive patients with controlled BP. Plasma levels of EPCs CD34+/KDR+ and CD34+/VE-cadherin+ were quantified by flow cytometry. Plasma concentration of VEGF was determined by ELISA. A group of healthy subjects without cardiovascular risk factors was included as controls. A total of 108 hypertensive patients were included (61±12 years, 47.2% men) of which 82.4% showed BP<140/90 mmHg, 91.7% and 81.5% controlled diabetes (HbA1c <7%) and cLDL (<130 or 100 mg/dL), respectively, and 85.2% were non-smokers. Around 45% of them were obese. Although patients had cardiovascular parameters within normal ranges, they showed significantly lower levels of CD34+/KDR+ and CD34+/VE-cadherin+ compared with healthy control group, although plasma VEGF concentration was higher in patients than in controls. Despite an optimal treatment, hypertensive patients show a decreased number of circulating EPCs that could be, at least in part, responsible for their residual cardiovascular risk, suggesting that these cells could be a therapeutic target. Copyright © 2015 SEHLELHA. Published by Elsevier España, S.L.U. All rights reserved.

  15. Southern Hemisphere extratropical circulation: Recent trends and natural variability

    Science.gov (United States)

    Thomas, Jordan L.; Waugh, Darryn W.; Gnanadesikan, Anand

    2015-07-01

    Changes in the Southern Annular Mode (SAM), Southern Hemisphere (SH) westerly jet location, and magnitude are linked with changes in ocean circulation along with ocean heat and carbon uptake. Recent trends have been observed in these fields but not much is known about the natural variability. Here we aim to quantify the natural variability of the SH extratropical circulation by using Coupled Model Intercomparison Project Phase 5 (CMIP5) preindustrial control model runs and compare with the observed trends in SAM, jet magnitude, and jet location. We show that trends in SAM are due partly to external forcing but are not outside the natural variability as described by these models. Trends in jet location and magnitude, however, lie outside the unforced natural variability but can be explained by a combination of natural variability and the ensemble mean forced trend. These results indicate that trends in these three diagnostics cannot be used interchangeably.

  16. Circulation of authorizations - Authority as a material and processuel configuration

    DEFF Research Database (Denmark)

    Benjaminsen, Nana

    Despret's (2004) notion ‘making available' will be used to unfold new propositions and boundaries of authority in the fluid movable landscape of computer enhanced learning. In the second part of the paper, I will advocate that circulations of authorizations occur. When expectations are fulfilled...... the possibility of building objects with Lego bricks in combinations with engines and sensors, and to control their creation through a computer program.   In the example, this paper addresses, children and lego boxes were distributed to different computer workstations in two connected rooms. Electronic devises......, children, half build robots and teachers were more or less constantly moving, and circulating in the two classrooms. I argue that this is challenging what in common practise would be called the teacher's authority. Through the empirical example provided, and in line with the sociomaterial engagement...

  17. FFTF operating experience with sodium natural circulation: slides included

    Energy Technology Data Exchange (ETDEWEB)

    Burke, T.M.; Additon, S.L.; Beaver, T.R.; Midgett, J.C.

    1981-01-01

    The Fast Flux Test Facility (FFTF) has been designed for passive, back-up, safety grade decay heat removal utilizing natural circulation of the sodium coolant. This paper discusses the process by which operator preparation for this emergency operating mode has been assured, in paralled with the design verification during the FFTF startup and acceptance testing program. Over the course of the test program, additional insights were gained through the testing program, through on-going plant analyses and through general safety evaluations performed throughout the nuclear industry. These insights led to development of improved operator training material for control of decay heat removal during both forced and natural circulation as well as improvements in the related plant operating procedures.

  18. FFTF operating experience with sodium natural circulation: slides included

    International Nuclear Information System (INIS)

    Burke, T.M.; Additon, S.L.; Beaver, T.R.; Midgett, J.C.

    1981-01-01

    The Fast Flux Test Facility (FFTF) has been designed for passive, back-up, safety grade decay heat removal utilizing natural circulation of the sodium coolant. This paper discusses the process by which operator preparation for this emergency operating mode has been assured, in paralled with the design verification during the FFTF startup and acceptance testing program. Over the course of the test program, additional insights were gained through the testing program, through on-going plant analyses and through general safety evaluations performed throughout the nuclear industry. These insights led to development of improved operator training material for control of decay heat removal during both forced and natural circulation as well as improvements in the related plant operating procedures

  19. Estuarine turbidity, flushing, salinity, and circulation

    Science.gov (United States)

    Pritchard, D. W.

    1972-01-01

    The effects of estuarine turbidity, flushing, salinity, and circulation on the ecology of the Chesapeake Bay are discussed. The sources of fresh water, the variations in salinity, and the circulation patterns created by temperature and salinity changes are analyzed. The application of remote sensors for long term observation of water temperatures is described. The sources of sediment and the biological effects resulting from increased sediments and siltation are identified.

  20. [Circulating tumor cells: cornerstone of personalized medicine].

    Science.gov (United States)

    Rafii, A; Vidal, F; Rathat, G; Alix-Panabières, C

    2014-11-01

    Cancer treatment has evolved toward personalized medicine. It is mandatory for clinicians to ascertain tumor biological features in order to optimize patients' treatment. Identification and characterization of circulating tumor cells demonstrated a prognostic value in many solid tumors. Here, we describe the main technologies for identification and characterization of circulating tumor cells and their clinical application in gynecologic and breast cancers. Copyright © 2014. Published by Elsevier Masson SAS.

  1. Themes on circulation in the third world.

    Science.gov (United States)

    Chapman, M; Prothero, R M

    1983-01-01

    "This article focuses upon circulation, or reciprocal flows of people, with specific reference to Third World societies." Aspects considered include attempts to standardize terminology and to formulate typologies of population movement; the development of explanatory models of circulation and modernization, social networks, family welfare, and capitalism; and "the transfer of methods and concepts to societies and populations different from those from which they initially evolved and in which they were first tested." excerpt

  2. Gold-195m for studies on regional pulmonary circulation

    International Nuclear Information System (INIS)

    Eriksson, L.; Andersson, L.; Jonson, B.; Westling, H.; White, T.; Wollmer, P.

    1985-01-01

    Six healthy controls, seven patients with coronary heart disease (CHD), and five patients with exercise-induced asthma (EIA) were studied in the sitting position at rest and during maximum exercise. The radionuclide gold-195m was used in the studies. A redistribution of activity toward the lung apex was found during exercise, the change being more pronounced in the healthy controls than in the patients with CHD. In two of the three patients in which exercise induced an asthmatic attack, gross reductions in the activity were seen in different areas of the lung. The authors conclude that gold-195m can be used for studies of rapid changes in regional pulmonary circulation

  3. GREENHOUSE GAS EMISSIONS CONTROL BY OXYGEN FIRING IN CIRCULATING FLUIDIZED BED BOILERS: PHASE II--PILOT SCALE TESTING AND UPDATED PERFORMANCE AND ECONOMICS FOR OXYGEN FIRED CFB WITH CO2 CAPTURE

    Energy Technology Data Exchange (ETDEWEB)

    Nsakala ya Nsakala; Gregory N. Liljedahl; David G. Turek

    2004-10-27

    Because fossil fuel fired power plants are among the largest and most concentrated producers of CO{sub 2} emissions, recovery and sequestration of CO{sub 2} from the flue gas of such plants has been identified as one of the primary means for reducing anthropogenic CO{sub 2} emissions. In this Phase II study, ALSTOM Power Inc. (ALSTOM) has investigated one promising near-term coal fired power plant configuration designed to capture CO{sub 2} from effluent gas streams for sequestration. Burning fossil fuels in mixtures of oxygen and recirculated flue gas (made principally of CO{sub 2}) essentially eliminates the presence of atmospheric nitrogen in the flue gas. The resulting flue gas is comprised primarily of CO{sub 2}, along with some moisture, nitrogen, oxygen, and trace gases like SO{sub 2} and NO{sub x}. Oxygen firing in utility scale Pulverized Coal (PC) fired boilers has been shown to be a more economical method for CO{sub 2} capture than amine scrubbing (Bozzuto, et al., 2001). Additionally, oxygen firing in Circulating Fluid Bed Boilers (CFB's) can be more economical than in PC or Stoker firing, because recirculated gas flow can be reduced significantly. Oxygen-fired PC and Stoker units require large quantities of recirculated flue gas to maintain acceptable furnace temperatures. Oxygen-fired CFB units, on the other hand, can accomplish this by additional cooling of recirculated solids. The reduced recirculated gas flow with CFB plants results in significant Boiler Island cost savings resulting from reduced component The overall objective of the Phase II workscope, which is the subject of this report, is to generate a refined technical and economic evaluation of the Oxygen fired CFB case (Case-2 from Phase I) utilizing the information learned from pilot-scale testing of this concept. The objective of the pilot-scale testing was to generate detailed technical data needed to establish advanced CFB design requirements and performance when firing coals and

  4. Surgical myocardial revascularization without extracorporeal circulation

    Directory of Open Access Journals (Sweden)

    Salomón Soriano Ordinola Rojas

    2003-05-01

    Full Text Available OBJECTIVE: To assess the immediate postoperative period of patients undergoing myocardial revascularization without extracorporeal circulation with different types of grafts. METHODS: One hundred and twelve patients, 89 (79.5% of whom were males, were revascularized without extracorporeal circulation. Their ages ranged from 39 to 85 years. The criteria for indicating myocardial revascularization without extracorporeal circulation were as follows: revascularized coronary artery caliber > 1.5 mm, lack of intramyocardial trajectory on coronary angiography, noncalcified coronary arteries, and tolerance of the heart to the different rotation maneuvers. RESULTS: Myocardial revascularization without extracorporeal circulation was performed in 112 patients. Three were converted to extracorporeal circulation, which required a longer hospital stay but did not impact mortality. During the procedure, the following events were observed: atrial fibrillation in 10 patients, ventricular fibrillation in 4, total transient atrioventricular block in 2, ventricular extrasystoles in 58, use of a device to retrieve red blood cells in 53, blood transfusion in 8, and arterial hypotension in 89 patients. Coronary angiography was performed in 20 patients on the seventh postoperative day when the grafts were patent. CONCLUSION: Myocardial revascularization without extracorporeal circulation is a reproducible technique that is an alternative for treating ischemic heart disease.

  5. Circulating Nesfatin-1 Levels and Type 2 Diabetes: A Systematic Review and Meta-Analysis

    OpenAIRE

    Zhai, Ting; Li, Shi-Zhen; Fan, Xin-Tong; Tian, Zhao; Lu, Xiao-Qing; Dong, Jing

    2017-01-01

    The role of nesfatin-1 in glucose homeostasis has been investigated previously. However, although numerous studies have examined the relationships between circulating nesfatin-1 levels and type 2 diabetes, the conclusions are contradictory. We aimed to probe the relationship between circulating nesfatin-1 levels and type 2 diabetes by meta-analysis. Seven studies including 328 type 2 diabetes patients and 294 control subjects were included. Although there was no obvious difference in circulat...

  6. Operating experience with gas-bearing circulators in a high-pressure helium loop

    International Nuclear Information System (INIS)

    Sanders, J.P.; Gat, U.; Young, H.C.

    1988-01-01

    A high-pressure engineering test loop has been designed and constructed at the Oak Ridge National Laboratory for circulating helium through a test chamber at temperatures to 1,000 deg. C. The purpose of this loop is to determine the thermal and structural performance of proposed components for the primary loops of gas-cooled nuclear reactors. Three gas-bearing circulators, mounted in series, provide a maximum volumetric flow of 0.47 m 3 /s and a maximum head of 78 kJ/kg at operating pressures from 0.1 to 10.7 MPa. Control of gaseous impurities in the circulating gas was the significant operating requirement that dictated the choice of a circulator that is lubricated by the circulating gas. The motor for each circulator is contained within the pressure boundary, and it is cooled by circulating the gas in the motor cavity over water-cooled coils. Each motor is rated at 200 kW at a speed of 23,500 rpm. The circulators have been operated in the loop for more than 5,000 h. The flow of the gas in the loop is controlled by varying the speed of the circulators through the use of individual 250-kVA, solid state power supplies that can be continuously varied in frequency from 50 to 400 Hz. To prevent excessive wear on the gas bearings during startup, the circulator motor accelerates the rotor to 3,000 rpm in less than one second. During operation, no problems associated with the gas bearings, per se, were encountered; however, related problems pointed to design considerations that should be included in future applications of circulators of this type. The primary test that has been conducted in this loop required sustained operation for several weeks without interruption. After a number of unscheduled interruptions, the operating goals were attained. During part of this period, the loop was operated with only two circulators installed in the pressure vessels with a guard installed in the third vessel to protect the closure flange from the gas temperatures. Unattended

  7. Eddy Effects in the General Circulation, Spanning Mean Currents, Mesoscale Eddies, and Topographic Generation, Including Submesoscale Nests

    Science.gov (United States)

    2014-09-30

    alongshore winds favoring upwelling circulation. As for the other EBUS (e.g., Humboldt, Benguela, and Canary Currents ), equatorward winds drive...Eddy Effects in the General Circulation, Spanning Mean Currents , Mesoscale Eddies, and Topographic Generation, Including Submesoscale Nests...environments OBJECTIVES The central scientific questions are how the eddies control the persistent currents by their eddy-induced momentum and buoyancy fluxes

  8. The relationship between sea surface temperature anomalies and atmospheric circulation in general circulation model experiments

    International Nuclear Information System (INIS)

    Kharin, V.V.

    1994-01-01

    Several multi-year integrations of the Hamburg version of the ECMWF/T21 general circulation model driven by the sea surface temperature (SST) observed in the period 1970-1988 were examined to study the extratropical response of the atmospheric circulation to SST anomalies in the Northern Hemisphere in winter. In the first 19-years run SST anomalies were prescribed globally (GAGO run), and in two others SST variability was limited to extratropical regions (MOGA run) and to tropics (TOGA run), respectively. A canonical correlation analysis was applied to the monthly means to find the best correlated patterns of SST anomalies in the Atlantic and Pacific Oceans and the Northern Hemisphere atmospheric flow. Contrary to expectation, the extratropical response in the GAGO run is not equal to the linear combination of the responses in the MOGA and TOGA runs. In the GAGO integration with globally prescribed SST the best correlated atmospheric pattern is global and is characterized by dipole structures of the same polarity in the North Atlantic and the North Pacific sectors. In the MOGA and TOGA experiments the atmospheric response is more local with main centers in the North Atlantic and North Pacific, respectively. The atmospheric modes found by the CCA were compared with the normal modes of the barotropic vorticity equation linearized about the 500 mb winter climate of the control integration driven by the climatological SST. The normal modes with smallest eigenvalues are similar to the canonical patterns of 500 mb geopotential height. The corresponding eigenvectors of the adjoint operator, which represent an external forcing optimal for exciting normal modes, have a longitudinal structure with maxima in regions characterized by enhanced high frequency baroclinic activity over both oceans. It was suggested that variability of storm tracks could play an important role in variability of the barotropic normal modes. (orig.)

  9. Field estimates of groundwater circulation depths in two mountainous watersheds in the western U.S. and the effect of deep circulation on solute concentrations in streamflow

    Science.gov (United States)

    Frisbee, Marty D.; Tolley, Douglas G.; Wilson, John L.

    2017-04-01

    Estimates of groundwater circulation depths based on field data are lacking. These data are critical to inform and refine hydrogeologic models of mountainous watersheds, and to quantify depth and time dependencies of weathering processes in watersheds. Here we test two competing hypotheses on the role of geology and geologic setting in deep groundwater circulation and the role of deep groundwater in the geochemical evolution of streams and springs. We test these hypotheses in two mountainous watersheds that have distinctly different geologic settings (one crystalline, metamorphic bedrock and the other volcanic bedrock). Estimated circulation depths for springs in both watersheds range from 0.6 to 1.6 km and may be as great as 2.5 km. These estimated groundwater circulation depths are much deeper than commonly modeled depths suggesting that we may be forcing groundwater flow paths too shallow in models. In addition, the spatial relationships of groundwater circulation depths are different between the two watersheds. Groundwater circulation depths in the crystalline bedrock watershed increase with decreasing elevation indicative of topography-driven groundwater flow. This relationship is not present in the volcanic bedrock watershed suggesting that both the source of fracturing (tectonic versus volcanic) and increased primary porosity in the volcanic bedrock play a role in deep groundwater circulation. The results from the crystalline bedrock watershed also indicate that relatively deep groundwater circulation can occur at local scales in headwater drainages less than 9.0 km2 and at larger fractions than commonly perceived. Deep groundwater is a primary control on streamflow processes and solute concentrations in both watersheds.

  10. Circulating irisin levels are positively associated with metabolic risk factors in sedentary subjects.

    Directory of Open Access Journals (Sweden)

    María Moreno

    Full Text Available A physically active life-style plays an independent role in the protection against type 2 diabetes and cardiovascular diseases. Irisin, a novel exercise-induced myokine, activates thermogenesis in rodents through increasing beige fat cells abundance within white fat. We aimed to investigate circulating irisin levels in association with the degree of physical activity and various metabolic parameters in humans.Circulating irisin levels (ELISA and metabolic parameters were analyzed in 428 subjects (195 men/233 women. Participants were classified according to their self-reported physical activity and to their area of residence.Circulating irisin levels were higher in active than in sedentary subjects (p = 0.006. Rural inhabitants showed higher circulating irisin levels than urban subjects (p < 0.0001. The increase in irisin levels related to an active lifestyle was only observed in rural citizens (p = 0.014. Among sedentary participants, irisin levels were positively associated with metabolic risk factors (BMI, fasting insulin, HOMA and fasting triglycerides. The area of residence (β = - 0.592, p = < 0.0001 contributed independently to circulating irisin levels variance after controlling for age, gender, BMI, HOMAIR, triglycerides and physical activity.In sedentary participants, circulating irisin levels were positively associated with parameters related to an increased cardiometabolic risk. The present study confirmed that an active lifestyle increases circulating irisin levels, but only among subjects living in a rural environment. Area of residence might be a determinant of irisin levels.

  11. Helium circulator design concepts for the modular high temperature gas-cooled reactor (MHTGR) plant

    International Nuclear Information System (INIS)

    McDonald, C.F.; Nichols, M.K.; Kaufman, J.S.

    1988-01-01

    Two helium circulators are featured in the Modular High-Temperature Gas-Cooled Reactor (MHTGR) power plant - (1) the main circulator, which facilitates the transfer of reactor thermal energy to the steam generator, and (2) a small shutdown cooling circulator that enables rapid cooling of the reactor system to be realized. The 3170 kW(e) main circulator has an axial flow compressor, the impeller being very similar to the unit in the Fort St. Vrain (FSV) plant. The 164 kW(e) shutdown cooling circulator, the design of which is controlled by depressurized conditions, has a radial flow compressor. Both machines are vertically oriented, have submerged electric motor drives, and embody rotors that are supported on active magnetic bearings. As outlined in this paper, both machines have been conservatively designed based on established practice. The circulators have features and characteristics that have evolved from actual plant operating experience. With a major goal of high reliability, emphasis has been placed on design simplicity, and both machines are readily accessible for inspection, repair, and replacement, if necessary. In this paper, conceptual design aspects of both machines are discussed, together with the significant technology bases. As appropriate for a plant that will see service well into the 21st century, new and emerging technologies have been factored into the design. Examples of this are the inclusion of active magnetic bearings, and an automated circulator condition monitoring system. (author). 18 refs, 20 figs, 13 tabs

  12. Hypoxia, leukocytes, and the pulmonary circulation.

    Science.gov (United States)

    Stenmark, Kurt R; Davie, Neil J; Reeves, John T; Frid, Maria G

    2005-02-01

    Data are rapidly accumulating in support of the idea that circulating monocytes and/or mononuclear fibrocytes are recruited to the pulmonary circulation of chronically hypoxic animals and that these cells play an important role in the pulmonary hypertensive process. Hypoxic induction of monocyte chemoattractant protein-1, stromal cell-derived factor-1, vascular endothelial growth factor-A, endothelin-1, and tumor growth factor-beta(1) in pulmonary vessel wall cells, either directly or indirectly via signals from hypoxic lung epithelial cells, may be a critical first step in the recruitment of circulating leukocytes to the pulmonary circulation. In addition, hypoxic stress appears to induce release of increased numbers of monocytic progenitor cells from the bone marrow, and these cells may have upregulated expression of receptors for the chemokines produced by the lung circulation, which thus facilitates their specific recruitment to the pulmonary site. Once present, macrophages/fibrocytes may exert paracrine effects on resident pulmonary vessel wall cells stimulating proliferation, phenotypic modulation, and migration of resident fibroblasts and smooth muscle cells. They may also contribute directly to the remodeling process through increased production of collagen and/or differentiation into myofibroblasts. In addition, they could play a critical role in initiating and/or supporting neovascularization of the pulmonary artery vasa vasorum. The expanded vasa network may then act as a conduit for further delivery of circulating mononuclear cells to the pulmonary arterial wall, creating a feedforward loop of pathological remodeling. Future studies will need to determine the mechanisms that selectively induce leukocyte/fibrocyte recruitment to the lung circulation under hypoxic conditions, their direct role in the remodeling process via production of extracellular matrix and/or differentiation into myofibroblasts, their impact on the phenotype of resident smooth muscle

  13. Study on operational aspect of natural circulation HLMC reactor (1)

    International Nuclear Information System (INIS)

    Sienicki, J.J.; Cahalan, J.E.; Spencer, B.W.

    2000-08-01

    The concept of a heavy liquid metal cooled fast reactor that achieves 100% natural circulation heat removal from the core has the potential to attain improved cost competitiveness through extreme simplification, proliferation resistance, and heightened passive safety. The concept offers the potential for simplifications in plant control strategies wherein inherent reactor feedbacks may restore balance between energy release and heat removal from the reactor during operation as well as providing passive reactivity shutdown in the event of transients involving failure to scram. This study was initiated to evaluate the operational characteristics of the 100% natural circulation reactor under normal and transient states using a plant dynamics analysis computer code and to seek design and operational optimization of the concept. In the current Phase I of the project, the stage for the overall study has been prepared. A coupled thermal hydraulics-kinetics plant dynamics analysis code has been developed/modified that has the capabilities to calculate operational and accident transients. Code input has been prepared for the heavy liquid metal cooled natural circulation reactor concept. A preliminary analysis using the plant dynamics code and its input to calculate three illustrative cases relevant to initial startup, shutdown following long-term operation, and change in turbine load demonstrates the capability to analyze typical transient cases. (author)

  14. Circulating microRNAs as Potential Biomarkers of Infectious Disease

    Science.gov (United States)

    Correia, Carolina N.; Nalpas, Nicolas C.; McLoughlin, Kirsten E.; Browne, John A.; Gordon, Stephen V.; MacHugh, David E.; Shaughnessy, Ronan G.

    2017-01-01

    microRNAs (miRNAs) are a class of small non-coding endogenous RNA molecules that regulate a wide range of biological processes by post-transcriptionally regulating gene expression. Thousands of these molecules have been discovered to date, and multiple miRNAs have been shown to coordinately fine-tune cellular processes key to organismal development, homeostasis, neurobiology, immunobiology, and control of infection. The fundamental regulatory role of miRNAs in a variety of biological processes suggests that differential expression of these transcripts may be exploited as a novel source of molecular biomarkers for many different disease pathologies or abnormalities. This has been emphasized by the recent discovery of remarkably stable miRNAs in mammalian biofluids, which may originate from intracellular processes elsewhere in the body. The potential of circulating miRNAs as biomarkers of disease has mainly been demonstrated for various types of cancer. More recently, however, attention has focused on the use of circulating miRNAs as diagnostic/prognostic biomarkers of infectious disease; for example, human tuberculosis caused by infection with Mycobacterium tuberculosis, sepsis caused by multiple infectious agents, and viral hepatitis. Here, we review these developments and discuss prospects and challenges for translating circulating miRNA into novel diagnostics for infectious disease. PMID:28261201

  15. Circulating water pumps for nuclear power stations

    International Nuclear Information System (INIS)

    Satoh, Hiroshi; Ohmori, Tsuneaki

    1979-01-01

    Shortly, the nuclear power station with unit power output of 1100 MW will begin the operation, and the circulating water pumps manufactured recently are those of 2.4 to 4 m bore, 840 to 2170 m 3 /min discharge and 2100 to 5100 kW driving power. The circulating water pumps are one of important auxiliary machines, because if they fail, power generation capacity lowers immediately. Enormous quantity of cooling water is required to cool condensers, therefore in Japan, sea water is usually used. As siphon is formed in circulating water pipes, the total head of the pumps is not very high. The discharge of the pumps is determined so as to keep the temperature rise of discharged water lower than 7 deg. C. The quantity of cooling water for nuclear power generation is about 50% more as compared with thermal power generation because of the difference in steam conditions. The total head of the pumps is normally from 8 to 15 m. The circulating water pumps rarely stop after they started the operation, therefore it is economical to determine the motor power so that it can withstand 10% overload for a short period, instead of large power. At present, vertical shaft, oblique flow circulating water pumps are usually employed. Recently, movable blade pumps are adopted. The installation, construction and materials of the pumps and the problems are described. (Kako, I.)

  16. Cascade of circulations in fluid turbulence.

    Science.gov (United States)

    Eyink, Gregory L

    2006-12-01

    Kelvin's theorem on conservation of circulations is an essential ingredient of Taylor's theory of turbulent energy dissipation by the process of vortex-line stretching. In previous work, we have proposed a nonlinear mechanism for the breakdown of Kelvin's theorem in ideal turbulence at infinite Reynolds number. We develop here a detailed physical theory of this cascade of circulations. Our analysis is based upon an effective equation for large-scale coarse-grained velocity, which contains a turbulent-induced vortex force that can violate Kelvin's theorem. We show that singularities of sufficient strength, which are observed to exist in turbulent flow, can lead to nonvanishing dissipation of circulation for an arbitrarily small coarse-graining length in the effective equations. This result is an analog for circulation of Onsager's theorem on energy dissipation for singular Euler solutions. The physical mechanism of the breakdown of Kelvin's theorem is diffusion of lines of large-scale vorticity out of the advected loop. This phenomenon can be viewed as a classical analog of the Josephson-Anderson phase-slip phenomenon in superfluids due to quantized vortex lines. We show that the circulation cascade is local in scale and use this locality to develop concrete expressions for the turbulent vortex force by a multiscale gradient expansion. We discuss implications for Taylor's theory of turbulent dissipation and we point out some related cascade phenomena, in particular for magnetic flux in magnetohydrodynamic turbulence.

  17. Engineering, Manufacture and Preliminary Testing of the ITER Toroidal Field (TF) Magnet Helium Cold Circulator

    Science.gov (United States)

    Rista, P. E. C.; Shull, J.; Sargent, S.

    2015-12-01

    The ITER cryodistribution system provides the supercritical Helium (SHe) forced flow cooling to the magnet system using cold circulators. The cold circulators are located in each of five separate auxiliary cold boxes planned for use in the facility. Barber-Nichols Inc. has been awarded a contract from ITER-India for engineering, manufacture and testing of the Toroidal Field (TF) Magnet Helium Cold Circulator. The cold circulator will be extensively tested at Barber-Nichols’ facility prior to delivery for qualification testing at the Japan Atomic Energy Agency's (JAEA) test facility at Naka, Japan. The TF Cold Circulator integrates features and technical requirements which Barber-Nichols has utilized when supplying helium cold circulators worldwide over a period of 35 years. Features include a vacuum-jacketed hermetically sealed design with a very low helium leak rate, a heat shield for use with both nitrogen & helium cold sources, a broad operating range with a guaranteed isentropic efficiency over 70%, and impeller design features for high efficiency. The cold circulator will be designed to meet MTBM of 17,500 hours and MTBF of 36,000 hours. Vibration and speed monitoring are integrated into a compact package on the rotating assembly with operation and health monitoring in a multi-drop PROFIBUS communication environment using an electrical cabinet with critical features and full local and network PLC interface and control. For the testing in Japan and eventual installation in Europe, the cold circulator must be certified to the Japanese High Pressure Gas Safety Act (JHPGSA) and CE marked in compliance with the European Pressure Equipment Directive (PED) including Essential Safety Requirements (ESR). The test methodology utilized at Barber-Nichols’ facility and the resulting test data, validating the high efficiency of the TF Cold Circulator across a broad operating range, are important features of this paper.

  18. Engineering, Manufacture and Preliminary Testing of the ITER Toroidal Field (TF) Magnet Helium Cold Circulator

    International Nuclear Information System (INIS)

    C Rista, P E; Shull, J; Sargent, S

    2015-01-01

    The ITER cryodistribution system provides the supercritical Helium (SHe) forced flow cooling to the magnet system using cold circulators. The cold circulators are located in each of five separate auxiliary cold boxes planned for use in the facility. Barber-Nichols Inc. has been awarded a contract from ITER-India for engineering, manufacture and testing of the Toroidal Field (TF) Magnet Helium Cold Circulator. The cold circulator will be extensively tested at Barber-Nichols’ facility prior to delivery for qualification testing at the Japan Atomic Energy Agency's (JAEA) test facility at Naka, Japan. The TF Cold Circulator integrates features and technical requirements which Barber-Nichols has utilized when supplying helium cold circulators worldwide over a period of 35 years. Features include a vacuum-jacketed hermetically sealed design with a very low helium leak rate, a heat shield for use with both nitrogen and helium cold sources, a broad operating range with a guaranteed isentropic efficiency over 70%, and impeller design features for high efficiency. The cold circulator will be designed to meet MTBM of 17,500 hours and MTBF of 36,000 hours. Vibration and speed monitoring are integrated into a compact package on the rotating assembly with operation and health monitoring in a multi-drop PROFIBUS communication environment using an electrical cabinet with critical features and full local and network PLC interface and control. For the testing in Japan and eventual installation in Europe, the cold circulator must be certified to the Japanese High Pressure Gas Safety Act (JHPGSA) and CE marked in compliance with the European Pressure Equipment Directive (PED) including Essential Safety Requirements (ESR). The test methodology utilized at Barber-Nichols’ facility and the resulting test data, validating the high efficiency of the TF Cold Circulator across a broad operating range, are important features of this paper. (paper)

  19. Circulation as Assessment: Collection Development Policies Evaluated in Terms of Circulation at a Small Academic Library.

    Science.gov (United States)

    Dinkins, Debbi

    2003-01-01

    Discusses the use of academic library circulation statistics to assess whether user needs are being met and describes a study at Stetson University that investigated collection development practices by comparing circulation statistics for books selected by faculty in support of departmental curricula with those of librarian selections. (Author/LRW)

  20. An Embedded Based Digital Controller for Thermal Process

    Directory of Open Access Journals (Sweden)

    A. Lakshmi Sangeetha

    2008-01-01

    Full Text Available This paper describes a low cost virtual instrumentation (VI system to monitor and control the electrically heated water bath temperature. The PIC16F877 based digital microcontroller is used as thermostat which controls and monitors the temperature. The digital controller also allows the user to modify the sensor (PT100 calibration data values if necessary. The developed programmable on/off control function provides on-line display of measuring temperature, set point as well as the control function output plots through the parallel port. This bus interaction is realized in Visual Basic/Assembly Language and uses a 16 bit, 10 ms sampling analog-to-digital converter (ADS 7805 for monitoring and controlling the parameters of the temperature local digital controller.

  1. Elevated levels of cell-free circulating DNA in patients with acute dengue virus infection.

    Directory of Open Access Journals (Sweden)

    Tran Thi Ngoc Ha

    Full Text Available BACKGROUND: Apoptosis is thought to play a role in the pathogenesis of severe dengue and the release of cell-free DNA into the circulatory system in several medical conditions. Therefore, we investigated circulating DNA as a potential biomarker for severe dengue. METHODS AND FINDINGS: A direct fluorometric degradation assay using PicoGreen was performed to quantify cell-free DNA from patient plasma. Circulating DNA levels were significantly higher in patients with dengue virus infection than with other febrile illnesses and healthy controls. Remarkably, the increase of DNA levels correlated with the severity of dengue. Additionally, multivariate logistic regression analysis showed that circulating DNA levels independently correlated with dengue shock syndrome. CONCLUSIONS: Circulating DNA levels were increased in dengue patients and correlated with dengue severity. Additional studies are required to show the benefits of this biomarker in early dengue diagnosis and for the prognosis of shock complication.

  2. Theoretical research for natural circulation operational characteristic of ship nuclear machinery under ocean conditions

    Energy Technology Data Exchange (ETDEWEB)

    Yan Binghuo [Department of Nuclear Science and Engineering, Naval University of Engineering, Wuhan 430033 (China)], E-mail: yanbh1986@163.com; Yu Lei [Department of Nuclear Science and Engineering, Naval University of Engineering, Wuhan 430033 (China)], E-mail: yulei301@163.com

    2009-06-15

    Based on the two-phase drift flux model and the multi-pressure nodes matrix solving method, natural circulation thermal hydraulic analysis models for the Nuclear Machinery (NM) under ocean conditions are developed. The neutron physical activities and the responses of the reactivity control systems are described by the two-group, 3-dimensional space and time dependent neutron kinetics model. Reactivity feedback is calculated by coupling the neutron physics and thermal hydraulic codes, and is tested by comparison with experiments. Using the models developed, the natural circulation operating characteristics of NM in rolling and pitching motions and the transitions between forced circulation (FC) to natural circulation (NC) are analyzed. The results show that the influence of the rolling motion increases as the rolling amplitude is increased, and as the rolling period becomes shorter. The results also show that for this NM, with the same rolling period and rolling angle, the influence of pitching motion on natural circulation is greater than that of rolling motion. Furthermore, the oscillation period for pitching motion is the same as the pitching period, while the oscillation period for rolling is one half of the rolling period. In the ocean environment, excessive flow oscillation of the natural circulation may cause the control rods to respond so frequently that the NM would not be able to realize the transition from the FC to NC steadily. However, the influence of ocean environment on the transition from NC to FC is limited.

  3. Study of core flow distribution for small modular natural circulation lead or lead-alloy cooled fast reactors

    International Nuclear Information System (INIS)

    Chen, Zhao; Zhao, Pengcheng; Zhou, Guangming; Chen, Hongli

    2014-01-01

    Highlights: • A core flow distribution calculation code for natural circulation LFRs was developed. • The comparison study between the channel method and the CFD method was conducted. • The core flow distribution analysis and optimization design for a 10MW natural circulation LFR was conducted. - Abstract: Small modular natural circulation lead or lead-alloy cooled fast reactor (LFR) is a potential candidate for LFR development. It has many attractive advantages such as reduced capital costs and inherent safety. The core flow distribution calculation is an important issue for nuclear reactor design, which will provide important input parameters to thermal-hydraulic analysis and safety analysis. The core flow distribution calculation of a natural circulation LFR is different from that of a forced circulation reactor. In a forced circulation reactor, the core flow distribution can be controlled and adjusted by the pump power and the flow distributor, while in a natural circulation reactor, the core flow distribution is automatically adjusted according to the relationship between the local power and the local resistance feature. In this paper, a non-uniform heated parallel channel flow distribution calculation code was developed and the comparison study between the channel method and the CFD method was carried out to assess the exactness of the developed code. The core flow distribution analysis and optimization design for a 10MW natural circulation LFR was conducted using the developed code. A core flow distribution optimization design scheme for a 10MW natural circulation LFR was proposed according to the optimization analysis results

  4. Experimental study of the natural circulation phenomena

    International Nuclear Information System (INIS)

    Sabundjian, Gaiane; Andrade, Delvonei Alves de; Umbehaun, Pedro E.; Torres, Walmir M.; Castro, Alfredo Jose Alvim de; Belchior Junior, Antonio; Rocha, Ricardo Takeshi Vieira da; Damy, Osvaldo Luiz de Almeida; Torres, Eduardo

    2006-01-01

    The objective of this paper is to study the natural circulation in experimental loops and extend the results to nuclear facilities. New generation of compact nuclear power plants use the natural circulation as cooling and residual heat removal systems in case of accidents or shutdown. Lately the interest in this phenomenon, by scientific community, has increased. The experimental loop, described in this paper, was assembled at Escola Politecnica - USP at the Chemical Engineering Department. It is the goal to generate information to help with the understanding of the one and two phase natural circulation phenomena. Some experiments were performed with different levels of heat power and different flow of the cooling water at the secondary circuit. The data generated from these experiments are going to be used to validate some computational thermal hydraulic codes. Experimental results for one and two phase regimes are presented as well as the proposed model to simulate the flow regimes with the RELAP5 code. (author)

  5. Systems engineering requirements impacting MHTGR circulator design

    International Nuclear Information System (INIS)

    Chi, H.W.; Baccaglini, G.M.; Potter, R.C.; Shenoy, A.S.

    1988-01-01

    At the initiation of the MHTGR program, an important task involved translating the plant users' requirements into design conditions. This was particularly true in the case of the heat transport and shutdown cooling systems since these embody many components. This paper addresses the two helium circulators in these systems. An integrated approach is being used in the development of design and design documentation for the MHTGR plant. It is an organized and systematic development of plant functions and requirements, determined by top-down design, performance, and cost trade-off studies and analyses, to define the overall plant systems, subsystems, components, and human actions. These studies, that led to the identification of the major design parameters for the two circulators, are discussed in this paper. This includes the performance information, steady state and transient data, and the various interface requirements. The design of the circulators used in the MHTGR is presented. (author). 1 ref., 17 figs

  6. Circulating microRNAs in breast cancer

    DEFF Research Database (Denmark)

    Hamam, Rimi; Hamam, Dana; Alsaleh, Khalid A

    2017-01-01

    Effective management of breast cancer depends on early diagnosis and proper monitoring of patients' response to therapy. However, these goals are difficult to achieve because of the lack of sensitive and specific biomarkers for early detection and for disease monitoring. Accumulating evidence in ...... circulating miRNAs as diagnostic, prognostic or predictive biomarkers in breast cancer management.......Effective management of breast cancer depends on early diagnosis and proper monitoring of patients' response to therapy. However, these goals are difficult to achieve because of the lack of sensitive and specific biomarkers for early detection and for disease monitoring. Accumulating evidence...... in the past several years has highlighted the potential use of peripheral blood circulating nucleic acids such as DNA, mRNA and micro (mi)RNA in breast cancer diagnosis, prognosis and for monitoring response to anticancer therapy. Among these, circulating miRNA is increasingly recognized as a promising...

  7. Adjustable speed drives improve circulating water system

    International Nuclear Information System (INIS)

    Dent, R.A.; Dicic, Z.

    1994-01-01

    This paper illustrates the integration of electrical and mechanical engineering requirements to produce a solution to past problems and future operating demands. The application of adjustable speed drives in the modifications of the circulating water system at Indian Point No. 3 Nuclear Power Plant provided increased operating flexibility, efficiency and avoided otherwise costly renovations to the plant electrical systems. Rectification of the original inadequate design of the circulating water system, in addition to maximizing plant efficiency consistent with environmental considerations, formed the basis for this modification. This entailed replacement of all six circulating water pumps and motors and physical modifications to the intake system. This paper details the methodology used in this engineering task. The new system was installed successfully and has been operating reliably and economically for the past eight years

  8. Natural circulation in a scaled PWR integral test facility

    International Nuclear Information System (INIS)

    Kiang, R.L.; Jeuck, P.R. III

    1987-01-01

    Natural circulation is an important mechanism for cooling a nuclear power plant under abnormal operating conditions. To study natural circulation, we modeled a type of pressurized water reactor (PWR) that incorporates once-through steam generators. We conducted tests of single-phase natural circulations, two-phase natural circulations, and a boiler condenser mode. Because of complex geometry, the natural circulations observed in this facility exhibit some phenomena not commonly seen in a simple thermosyphon loop

  9. Fort St. Vrain circulator operating experience

    Energy Technology Data Exchange (ETDEWEB)

    Brey, H. L.

    1988-08-15

    Fort St. Vrain, on the system of Public Service Company of Colorado, is the only high-temperature gas-cooled power reactor in the United States. Four helium circulators are utilized in this plant to transfer heat from the reactor to the steam generators. These unique machines have a single stage axial flow helium compressor driven by a single stage steam turbine. A single stage water driven (pelton wheel) turbine is the back-up drive utilizing either feed water, condensate, or fire water as the driving fluid. Developmental testing of the circulators was accomplished prior to installation into Fort St. Vrain. A combined machine operating history of approximately 250,000 hours has shown these machines to be of conservative design and proven mechanical integrity. However, many problems have been encountered in operating the complex auxiliaries which are necessary for successful circulator and plant operation. It has been 15 years since initial installation of the circulators occurred at Fort St. Vrain. During this time, a number of significant issues had to be resolved dealing specifically with machine performance. These events include cavitation damage of the pelton wheels during the initial plant hot functional testing, cracks in the water turbine buckets and cervic coupling, static shutdown seal bellows failure, and, most recently, degradation of components within the steam drive assembly. Unreliable operation particularly with the circulator auxiliaries has been a focus of attention by Public Service Company of Colorado. Actions to replace or significantly modify the existing circulators and their auxiliaries are currently awaiting decisions concerning the long-term future of the Fort St. Vrain plant. (author). 10 refs, 7 figs, 2 tabs.

  10. Fort St. Vrain circulator operating experience

    International Nuclear Information System (INIS)

    Brey, H.L.

    1988-01-01

    Fort St. Vrain, on the system of Public Service Company of Colorado, is the only high-temperature gas-cooled power reactor in the United States. Four helium circulators are utilized in this plant to transfer heat from the reactor to the steam generators. These unique machines have a single stage axial flow helium compressor driven by a single stage steam turbine. A single stage water driven (pelton wheel) turbine is the back-up drive utilizing either feed water, condensate, or fire water as the driving fluid. Developmental testing of the circulators was accomplished prior to installation into Fort St. Vrain. A combined machine operating history of approximately 250,000 hours has shown these machines to be of conservative design and proven mechanical integrity. However, many problems have been encountered in operating the complex auxiliaries which are necessary for successful circulator and plant operation. It has been 15 years since initial installation of the circulators occurred at Fort St. Vrain. During this time, a number of significant issues had to be resolved dealing specifically with machine performance. These events include cavitation damage of the pelton wheels during the initial plant hot functional testing, cracks in the water turbine buckets and cervic coupling, static shutdown seal bellows failure, and, most recently, degradation of components within the steam drive assembly. Unreliable operation particularly with the circulator auxiliaries has been a focus of attention by Public Service Company of Colorado. Actions to replace or significantly modify the existing circulators and their auxiliaries are currently awaiting decisions concerning the long-term future of the Fort St. Vrain plant. (author). 10 refs, 7 figs, 2 tabs

  11. Circulating irisin levels are lower in patients with either stable coronary artery disease (CAD) or myocardial infarction (MI) versus healthy controls, whereas follistatin and activin A levels are higher and can discriminate MI from CAD with similar to CK-MB accuracy.

    Science.gov (United States)

    Anastasilakis, Athanasios D; Koulaxis, Dimitrios; Kefala, Nikoleta; Polyzos, Stergios A; Upadhyay, Jagriti; Pagkalidou, Eirini; Economou, Fotios; Anastasilakis, Chrysostomos D; Mantzoros, Christos S

    2017-08-01

    Several myokines are produced by cardiac muscle. We investigated changes in myokine levels at the time of acute myocardial infarction (MI) and following reperfusion in relation to controls. Patients with MI (MI Group, n=31) treated with percutaneous coronary intervention (PCI) were compared to patients with stable coronary artery disease (CAD) subjected to scheduled PCI (CAD Group, n=40) and controls with symptoms mimicking CAD without stenosis in angiography (Control Group, n=43). The number and degree of stenosis were recorded. Irisin, follistatin, follistatin-like 3, activin A and B, ALT, AST, CK and CK-MB were measured at baseline and 6 or 24h after the intervention. MI and CAD patients had lower irisin than controls (p<0.001). MI patients had higher follistatin, activin A, CK, CK-MB and AST than CAD patients and controls (all p≤0.001). None of the myokines changed following reperfusion. Circulating irisin was associated with the degree of stenosis in all patients (p=0.05). Irisin was not inferior to CK-MB in predicting MI while folistatin and activin A could discriminate MI from CAD patients with similar to CK-MB accuracy. None of these myokines was altered following PCI in contrast to CK-MB. Irisin levels are lower in MI and CAD implying that their production may depend on myocadial blood supply. Follistatin and activin A are higher in MI than in CAD suggesting increased release due to myocardial necrosis. They can predict MI with accuracy similar to CK-MB and their role in the diagnosis of MI remains to be confirmed by prospective large clinical studies. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Quenching phenomena in natural circulation loop

    International Nuclear Information System (INIS)

    Umekawa, Hisashi; Ozawa, Mamoru; Ishida, Naoki

    1995-01-01

    Quenching phenomena has been investigated experimentally using circulation loop of liquid nitrogen. During the quenching under natural circulation, the heat transfer mode changes from film boiling to nucleate boiling, and at the same time flux changes with time depending on the vapor generation rate and related two-phase flow characteristics. Moreover, density wave oscillations occur under a certain operating condition, which is closely related to the dynamic behavior of the cooling curve. The experimental results indicates that the occurrence of the density wave oscillation induces the deterioration of effective cooling of the heat surface in the film and the transition boiling regions, which results in the decrease in the quenching velocity

  13. Labour circulation and the urban labour process.

    Science.gov (United States)

    Standing, G

    1986-01-01

    The author investigates aspects of labor circulation, which he defines as "temporary movement between geographical areas for work or in search of work....[He attempts to determine] what roles have been played by labour circulation in the development of urban-industrial labour forces in the transition to industrial capitalism." Factors considered include the exploitation and oppression of labor migrants; the industrial-urban labor reserve; urban socioeconomic stratification and discrimination by age, sex, or race; the division of labor; and policy options. excerpt

  14. An elementary model of money circulation

    Science.gov (United States)

    Pokrovskii, Vladimir N.; Schinckus, Christophe

    2016-12-01

    This paper investigates money circulation for a system, consisting of a production system, the government, a central bank, commercial banks and many customers of the commercial banks. A set of equations for the system is written; the theory determines the main features of interaction between production and money circulation. Investigation of the equations in a steady-state situation reveals some relationship among output of the production system and monetary variables. The relation of quantity theory of money is confirmed, whereas a new concept of the efficiency of the system is introduced.

  15. Engineering Judgment and Natural Circulation Calculations

    International Nuclear Information System (INIS)

    Ferreri, J.C.; Ferreri, J.C.

    2011-01-01

    The analysis performed to establish the validity of computer code results in the particular field of natural circulation flow stability calculations is presented in the light of usual engineering practice. The effects of discretization and closure correlations are discussed and some hints to avoid undesired mistakes in the evaluations performed are given. Additionally, the results are presented for an experiment relevant to the way in which a (small) number of skilled, nuclear safety analysts and researchers react when facing the solution of a natural circulation problem. These results may be also framed in the concept of Engineering Judgment and are potentially useful for Knowledge Management activities.

  16. Quenching phenomena in natural circulation loop

    Energy Technology Data Exchange (ETDEWEB)

    Umekawa, Hisashi; Ozawa, Mamoru [Kansai Univ., Osaka (Japan); Ishida, Naoki [Daihatsu Motor Company, Osaka (Japan)

    1995-09-01

    Quenching phenomena has been investigated experimentally using circulation loop of liquid nitrogen. During the quenching under natural circulation, the heat transfer mode changes from film boiling to nucleate boiling, and at the same time flux changes with time depending on the vapor generation rate and related two-phase flow characteristics. Moreover, density wave oscillations occur under a certain operating condition, which is closely related to the dynamic behavior of the cooling curve. The experimental results indicates that the occurrence of the density wave oscillation induces the deterioration of effective cooling of the heat surface in the film and the transition boiling regions, which results in the decrease in the quenching velocity.

  17. Gland system, especially for nuclear power plant circulation pumps

    International Nuclear Information System (INIS)

    Skalicky, A.; Vesely, M.

    1975-01-01

    The invention claims a gland system suitable especially for the circulation pumps of nuclear power plants. The system prevents the release of the radioactive high-pressure cooling liquid in the atmosphere. The gland system consists of at least two mechanical glands arranged in series and of the closed circuit of the cooling high-pressure medium. The respective mechanical glands are linked with by-pass branches and discharge piping. The by-pass branches accommodating control manometers and flowmeters are linked with the storage reservoir with drain pipes provided with stop fittings. (Oy)

  18. An Interactive Computer-Based Circulation System: Design and Development

    Directory of Open Access Journals (Sweden)

    James S. Aagaard

    1972-03-01

    Full Text Available An on-line computer-based circulation control system has been installed at the Northwestern University library. Features of the system include self-service book charge, remote terminal inquiry and update, and automatic production of notices for call-ins and books available. Fine notices are also prepared daily and overdue notices weekly. Important considerations in the design of the system were to minimize costs of operation and to include technical services functions eventually. The system operates on a relatively small computer in a multiprogrammed mode.

  19. On the minimum circulating power of steady state tokamaks

    International Nuclear Information System (INIS)

    Itoh, K.; Itoh, S.; Fukuyama, A.; Yagi, M.

    1995-07-01

    Circulating power for the sustenance and profile control of the steady state tokamak plasmas is discussed. The simultaneous fulfillment of the MHD stability at high beta value, the improved confinement and the stationary equilibrium requires the rotation drive as well as the current drive. In addition to the current drive efficiency, the efficiency for the rotation drive is investigated. The direct rotation drive by the external torque, such as the case of beam injection, is not efficient enough. The mechanism and the magnitude of the spontaneous plasma rotation are studied. (author)

  20. Quantum spin circulator in Y junctions of Heisenberg chains

    Science.gov (United States)

    Buccheri, Francesco; Egger, Reinhold; Pereira, Rodrigo G.; Ramos, Flávia B.

    2018-06-01

    We show that a quantum spin circulator, a nonreciprocal device that routes spin currents without any charge transport, can be achieved in Y junctions of identical spin-1 /2 Heisenberg chains coupled by a chiral three-spin interaction. Using bosonization, boundary conformal field theory, and density matrix renormalization group simulations, we find that a chiral fixed point with maximally asymmetric spin conductance arises at a critical point separating a regime of disconnected chains from a spin-only version of the three-channel Kondo effect. We argue that networks of spin-chain Y junctions provide a controllable approach to construct long-sought chiral spin-liquid phases.

  1. MES lead bismuth forced circulation loop and test results

    International Nuclear Information System (INIS)

    Ono, Mikinori; Mine, Tatsuya; Kitano, Teruaki; Kamata, Kin-ya

    2003-01-01

    Liquid lead-bismuth is a promising material as future reactor coolant or intensive neutron source material for accelerator driven system (ADS). Mitsui Engineering and Shipbuilding Co., Ltd. (MES) completed lead-bismuth coolant (LBC) forced circulation loop in May 2001 and acquired engineering data on economizer, electro magnetic pump, electro magnetic flow meter and so on. For quality control of LBC, oxygen sensor and filtering element are developing using some hydrogen and moisture mixed gases. Structural materials corrosion test for accelerator driver system (ADS) will start soon. And thermal hydraulic test for ADS will start in tree years. (author)

  2. Sterilization of the artificial blood circulation apparatus with ozone

    Energy Technology Data Exchange (ETDEWEB)

    Pisarevskii, A A; Korukhov, N I.U.; Brazhnikov, E M; Konstantinova, M L; Razumovskii, S D

    1982-01-01

    Presented in this paper is the sterilization method of the assisted circulation unit. The method has been approved by stand testing and then applied for sterilizing the unit Ae, yeK-5 m when experimental implanting artificial heart. According to the method, ozone in concentration of 5 x 10(-3) moles/1 and with flow rate of 0,5 1/min is passed through an internal circuit of the unit during I h and 15 min. Control wash-out samples from lines have demonstrated complete sterility of the internal circuit. The method makes the sterilization process of such units much easier and may be recommended for clinical application.

  3. Public speaking stress-induced neuroendocrine responses and circulating immune cell redistribution in irritable bowel syndrome.

    Science.gov (United States)

    Elsenbruch, Sigrid; Lucas, Ayscha; Holtmann, Gerald; Haag, Sebastian; Gerken, Guido; Riemenschneider, Natalie; Langhorst, Jost; Kavelaars, Annemieke; Heijnen, Cobi J; Schedlowski, Manfred

    2006-10-01

    Augmented neuroendocrine stress responses and altered immune functions may play a role in the manifestation of functional gastrointestinal (GI) disorders. We tested the hypothesis that IBS patients would demonstrate enhanced psychological and endocrine responses, as well as altered stress-induced redistribution of circulating leukocytes and lymphocytes, in response to an acute psychosocial stressor when compared with healthy controls. Responses to public speaking stress were analyzed in N = 17 IBS patients without concurrent psychiatric conditions and N = 12 healthy controls. At baseline, immediately following public speaking, and after a recovery period, state anxiety, acute GI symptoms, cardiovascular responses, serum cortisol and plasma adrenocorticotropic hormone (ACTH) were measured, and numbers of circulating leukocytes and lymphocyte subpopulations were analyzed by flow cytometry. Public speaking led to significant cardiovascular activation, a significant increase in ACTH, and a redistribution of circulating leukocytes and lymphocyte subpopulations, including significant increases in natural killer cells and cytotoxic/suppressor T cells. IBS patients demonstrated significantly greater state anxiety both at baseline and following public speaking. However, cardiovascular and endocrine responses, as well as the redistribution of circulating leukocytes and lymphocyte subpopulations after public speaking stress, did not differ for IBS patients compared with controls. In IBS patients without psychiatric comorbidity, the endocrine response as well as the circulation pattern of leukocyte subpopulations to acute psychosocial stress do not differ from healthy controls in spite of enhanced emotional responses. Future studies should discern the role of psychopathology in psychological and biological stress responses in IBS.

  4. The effect of n-3 PUFAs on circulating adiponectin and leptin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.

    Science.gov (United States)

    Farimani, Azam Rezaei; Hariri, Mitra; Azimi-Nezhad, Mohsen; Borji, Abasalt; Zarei, Sadegh; Hooshmand, Elham

    2018-02-16

    N-3 PUFAs can potentially influence levels of inflammatory and non-inflammatory adipokines. Given the contradictory effects of n-3 PUFAs on serum levels of adipokines in type 2 diabetes, we conducted a systematic review and meta-analysis study of randomized placebo-controlled clinical trials that examined the effects of n-3 PUFAs on serum levels of leptin and adiponectin in patients with type 2 diabetes. The electronic databases, without regard to language restrictions including PubMed/Medline, Google Scholar, SCOPUS and ISI Web of Science until August 2017, were used to identify randomized controlled trials that assessed the effect of n-3 PUFAs on serum leptin and adiponectin concentrations in type 2 diabetes. Outcomes were extracted based on the mean ± SD as effect size at baseline and end of the intervention. Between-study heterogeneity was evaluated by the I 2 estimates and their 95% CIs. Funnel plot asymmetry was used to investigate the existence of publication bias. Stata software and Review Manager were used for statistical data analysis. Data from 10 eligible articles involved 494 subjects with type 2 diabetes mellitus (intervention groups = 254 and control groups = 240), with age between 44 and 70 years, treated with doses of 0.52-7.4 g/day n-3 PUFAs. Adiponectin concentration nonsignificantly increased by a MD = 0.17 µg/mL (95% CI - 0.11, 0.44). Also, leptin concentration nonsignificantly reduced by a MD = - 0.31 ng/mL (95% CI - 0.69, 0.07). Plant and marine sources of n-3 PUFAs can modify serum leptin and adiponectin levels by increasing adiponectin and decreasing leptin levels in patients with type 2 diabetes. Due to some limitations in this study, further studies are needed to reach a definitive conclusion about the effect of n-3 PUFAs on the levels of leptin and adiponectin in T2DM.

  5. Circulating Omentin-1 and Chronic Painful Temporomandibular Disorders.

    Science.gov (United States)

    Harmon, Jennifer B; Sanders, Anne E; Wilder, Rebecca S; Essick, Greg K; Slade, Gary D; Hartung, Jane E; Nackley, Andrea G

    To investigate the relationship between omentin-1 levels and painful temporomandibular disorders (TMD). In a case-control design, chronic painful TMD cases (n = 90) and TMD-free controls (n = 54) were selected from participants in the multisite OPPERA study (Orofacial Pain: Prospective Evaluation and Risk Assessment). Painful TMD case status was determined by examination using established Research Diagnostic Criteria for TMD (RDC/TMD). Levels of omentin-1 in stored blood plasma samples were measured by using an enzyme linked immunosorbent assay. Binary logistic regression was used to calculate the odds ratios (ORs) and 95% confidence limits (CLs) for the association between omentin-1 and painful TMD. Models were adjusted for study site, age, sex, and body mass index. The unadjusted association between omentin-1 and chronic painful TMD was statistically nonsignificant (P = .072). Following adjustment for covariates, odds of TMD pain decreased 36% per standard deviation increase in circulating omentin-1 (adjusted OR = 0.64; 95% CL: 0.43, 0.96; P = .031). Circulating levels of omentin-1 were significantly lower in painful TMD cases than controls, suggesting that TMD pain is mediated by inflammatory pathways.

  6. Steam generator and circulator model for the HELAP code

    International Nuclear Information System (INIS)

    Ludewig, H.

    1975-07-01

    An outline is presented of the work carried out in the 1974 fiscal year on the GCFBR safety research project consisting of the development of improved steam generator and circulator (steam turbine driven helium compressor) models which will eventually be inserted in the HELAP (1) code. Furthermore, a code was developed which will be used to generate steady state input for the primary and secondary sides of the steam generator. The following conclusions and suggestions for further work are made: (1) The steam-generator and circulator model are consistent with the volume and junction layout used in HELAP, (2) with minor changes these models, when incorporated in HELAP, could be used to simulate a direct cycle plant, (3) an explicit control valve model is still to be developed and would be very desirable to control the flow to the turbine during a transient (initially this flow will be controlled by using the existing check valve model); (4) the friction factor in the laminar flow region is computed inaccurately, this might cause significant errors in loss-of-flow accidents; and (5) it is felt that HELAP will still use a large amount of computer time and will thus be limited to design basis accidents without scram or loss of flow transients with and without scram. Finally it may also be used as a test bed for the development of prototype component models which would be incorporated in a more sophisticated system code, developed specifically for GCFBR's

  7. A randomized trial of social media from Circulation.

    Science.gov (United States)

    Fox, Caroline S; Bonaca, Marc A; Ryan, John J; Massaro, Joseph M; Barry, Karen; Loscalzo, Joseph

    2015-01-06

    Medical journals use social media to distribute the findings of published articles. Whether social media exposure to original articles improves article impact metrics is uncertain. Articles were randomized to receive targeted social media exposure from Circulation, including postings on the journal's Facebook and Twitter feeds. The primary end point was 30-day article page views. We conducted an intention-to-treat analysis comparing article page views by the Wilcoxon Rank sum test between articles randomized to social media as compared with those in the control group, which received no social media from Circulation. Prespecified subgroups included article type (population/clinical/basic), US versus non-US corresponding author, and whether the article received an editorial. Overall, 243 articles were randomized: 121 in the social media arm and 122 in the control arm. There was no difference in median 30-day page views (409 [social media] versus 392 [control], P=0.80). No differences were observed by article type (clinical, population, or basic science; P=0.19), whether an article had an editorial (P=0.87), or whether the corresponding author was from the United States (P=0.73). A social media strategy for a cardiovascular journal did not increase the number of times an article was viewed. Further research is necessary to understand and quantify the ways in which social media can increase the impact of published cardiovascular research. © 2014 American Heart Association, Inc.

  8. Effects of exercise training on circulating levels of Dickkpof-1 and secreted frizzled-related protein-1 in breast cancer survivors: A pilot single-blind randomized controlled trial.

    Directory of Open Access Journals (Sweden)

    Tae Ho Kim

    Full Text Available Wingless and integration site growth factor (Wnt signaling is a tumorigenesis-related signaling pathway. Dickkpof-1 (DKK1 and secreted frizzled-related protein-1 (SFRP1 are endogenous negative regulators of Wnt/β-catenin signaling. Accumulating evidence indicates that higher serum levels of DKK1 are correlated with poor prognosis of various types of cancer. Here, we investigated whether exercise training causes changes in the serum levels of DKK1 and SFRP1 in patients with breast cancer.Twenty-four breast cancer survivors, after chemo- or radiotherapy, participated in this single-blind randomized, controlled pilot study. Subjects were randomized to either an exercise program or a control group for 12 weeks and completed pre- and post-training tests for health-related fitness and body composition as well as blood biomarkers. The serum levels of DKK1 and SFRP1 were measured using enzyme-linked immunosorbent assay as the primary outcome.Exercise training for 12 weeks remarkably increased muscle strength, endurance, and flexibility and decreased body fat percentage, waist circumference, and visceral fat area (all p < 0.05. Exercise training lowered serum insulin levels and leptin/adiponectin ratios (all p < 0.05. The levels of DKK1 and SFRP1 were also significantly decreased by exercise training in breast cancer survivors (all p < 0.01.Our results indicate that DKK1 and SFRP1 may be potentially useful biomarkers for evaluating the beneficial effects of long-term exercise on physical fitness and metabolism as well as the prognosis of patients with cancer.ClinicalTrials.gov NCT02895178.

  9. Bed system performance in helium circulation mode

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yean Jin; Jung, Kwang Jin; Ahn, Do Hee; Chung, Hong Suk [UST, Daejeon (Korea, Republic of); Kang, Hee Suk [KAERI, Daejeon (Korea, Republic of); Yun, Sei Hun [NFRI, Deajeon (Korea, Republic of)

    2016-05-15

    As a part of the International Thermonuclear Experimental Reactor (ITER) Project, We have conducted an experiment for storing hydrogen to depleted uranium and zirconium cobalt. The helium blanket effect has been observed in experiments using metal hydrides. The collapse of the hydrogen isotopes are accompanied by the decay heat and helium-3. Helium-3 dramatically reduces the hydrogen isotope storage capacity by surrounding the metal. This phenomenon is called a helium blanket effect. In addition the authors are working on the recovery and removal techniques of helium-3. In this paper, we discuss the equipment used to test the helium blanket effect and the results of a helium circulation experiment. The helium-3 produced surrounds the storage material surface and thus disturbs the reaction of the storage material and the hydrogen isotope. Even if the amount of helium-3 is small, the storage capacity of the SDS bed significantly drops. This phenomenon is the helium blanket effect. To resolve this phenomenon, a circulating loop was introduced. Using a circulating system, helium can be separated from the storage material. We made a helium loop that includes a ZrCo bed. Then using a metal bellows pump, we tested the helium circulation.

  10. Periodontitis and increase in circulating oxidative stress

    Directory of Open Access Journals (Sweden)

    Takaaki Tomofuji

    2009-05-01

    Full Text Available Reactive oxygen species (ROS are products of normal cellular metabolism. However, excessive production of ROS oxidizes DNA, lipids and proteins, inducing tissue damage. Studies have shown that periodontitis induces excessive ROS production in periodontal tissue. When periodontitis develops, ROS produced in the periodontal lesion diffuse into the blood stream, resulting in the oxidation of blood molecules (circulating oxidative stress. Such oxidation may be detrimental to systemic health. For instance, previous animal studies suggested that experimental periodontitis induces oxidative damage of the liver and descending aorta by increasing circulating oxidative stress. In addition, it has been revealed that clinical parameters in chronic periodontitis patients showed a significant improvement 2 months after periodontal treatment, which was accompanied by a significant reduction of reactive oxygen metabolites in plasma. Improvement of periodontitis by periodontal treatment could reduce the occurrence of circulating oxidative stress. Furthermore, recent studies indicate that the increase in circulating oxidative stress following diabetes mellitus and inappropriate nutrition damages periodontal tissues. In such cases, therapeutic approaches to systemic oxidative stress might be necessary to improve periodontal health.

  11. Natural circulation under severe accident conditions

    International Nuclear Information System (INIS)

    Pafford, D.J.; Hanson, D.J.; Tung, V.X.; Chmielewski, S.V.

    1992-01-01

    Research is being conducted to better understand natural circulation phenomena in mixtures of steam and noncondensibles and its influence on the temperature of the vessel internals and the hot leg, pressurizer surge line, and steam generator tubes. The temperature of these structures is important because their failure prior to reactor vessel lower head failure could reduce the likelihood of containment failure as a result of direct containment heating. Computer code calculations (MELPROG, SCDAP/RELAP5/MOD3) predict high fluid temperatures in the upper plenum resulting from in-vessel natural circulation. Using a simple model for the guide tube phenomena, high upper plenum temperatures are shown to be consistent with the relatively low temperatures that were deduced metallurgically from leadscrews removed from the TMI-2 upper plenum. Evaluation of the capabilities of the RELAP5/MOD3 computer code to predict natural circulation behavior was also performed. The code was used to model the Westinghouse natural circulation experimental facility. Comparisons between code calculations and results from experiments show good agreement

  12. Detecting Holocene changes in thermohaline circulation

    OpenAIRE

    Keigwin, L. D.; Boyle, E. A.

    2000-01-01

    Throughout the last glacial cycle, reorganizations of deep ocean water masses were coincident with rapid millennial-scale changes in climate. Climate changes have been less severe during the present interglacial, but evidence for concurrent deep ocean circulation change is ambiguous.

  13. Opportunities in CARICOM Migration : Brain Circulation, Diasporic ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Opportunities in CARICOM Migration : Brain Circulation, Diasporic Tourism, and Investment. Between 1965 and 2000, about 12% of the Caribbean labour force moved to Canada and other developed countries, making the Caribbean the largest per capita source of emigrants in the world. Remittances from these emigrants ...

  14. Oceanic Circulation. A Programmed Unit of Instruction.

    Science.gov (United States)

    Marine Maritime Academy, Castine.

    This booklet contains a programmed lesson on oceanic circulation. It is designed to allow students to progress through the subject at their own speed. Since it is written in linear format, it is suggested that students proceed through the program from "frame" to succeeding "frame." Instructions for students on how to use the booklet are included.…

  15. 3D Visualization of Global Ocean Circulation

    Science.gov (United States)

    Nelson, V. G.; Sharma, R.; Zhang, E.; Schmittner, A.; Jenny, B.

    2015-12-01

    Advanced 3D visualization techniques are seldom used to explore the dynamic behavior of ocean circulation. Streamlines are an effective method for visualization of flow, and they can be designed to clearly show the dynamic behavior of a fluidic system. We employ vector field editing and extraction software to examine the topology of velocity vector fields generated by a 3D global circulation model coupled to a one-layer atmosphere model simulating preindustrial and last glacial maximum (LGM) conditions. This results in a streamline-based visualization along multiple density isosurfaces on which we visualize points of vertical exchange and the distribution of properties such as temperature and biogeochemical tracers. Previous work involving this model examined the change in the energetics driving overturning circulation and mixing between simulations of LGM and preindustrial conditions. This visualization elucidates the relationship between locations of vertical exchange and mixing, as well as demonstrates the effects of circulation and mixing on the distribution of tracers such as carbon isotopes.

  16. Efficient Circulation of Railway Rolling Stock

    NARCIS (Netherlands)

    Alfieri, A.; Groot, R.; Kroon, L.G.; Schrijver, A.

    2006-01-01

    Railway rolling stock (locomotives, carriages, and train units) is one of the most significant cost sources for operatorsof passenger trains, both public and private. Rolling stock costsare due to material acquisition, power supply, and material maintenance. The efficient circulation of rolling

  17. Efficient Circulation of Railway Rolling Stock

    NARCIS (Netherlands)

    A. Alfieri (Arianna); R. Groot (Rutger); L.G. Kroon (Leo); A. Schrijver (Lex)

    2002-01-01

    textabstractRailway rolling stock (locomotives, carriages, and train units) is one of the most significant cost sources for operatorsof passenger trains, both public and private. Rolling stock costsare due to material acquisition, power supply, and material maintenance. The efficient circulation of

  18. Controlling the temperature in Canadian homes

    International Nuclear Information System (INIS)

    Dewis, G.

    2008-01-01

    Programmable thermostats can be used to optimize the operation of heating and cooling systems by reducing system usage when occupants are asleep or when dwellings are unoccupied. This paper used the results of a 2006 households and the environment survey to examine how programmable thermostats are currently being used in Canadian households. The demographic factors associated with thermostat use were discussed, as well as how their usage varied in different areas of Canada. The study showed that most Canadian households set their temperature at between 20 to 22 degrees C during times when they are home and awake. Home temperatures were reduced to between 16 and 18 degrees C when household members were away or asleep. Only 4 out of 10 households used programmable thermostats. Of those who used programmable thermostats, only 7 in 10 programmed the thermostat to lower the temperature when occupants were asleep. Senior citizens and people with lower levels of education were less likely to use programmable thermostats. It was concluded that incentive programs and the distribution of free programmable thermostats will increase their use in households. Assistance in programming during the installation process should also be provided. Factor analyses must also be conducted to examine the influence of age, education, and income and the decisions made by households in relation to temperature regulation. 7 tabs

  19. Circulating 25-Hydroxyvitamin D and Risk of Epithelial Ovarian Cancer

    Science.gov (United States)

    Zheng, Wei; Danforth, Kim N.; Tworoger, Shelley S.; Goodman, Marc T.; Arslan, Alan A.; Patel, Alpa V.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Kolonel, Laurence N.; Purdue, Mark P.; Shu, Xiao-Ou; Snyder, Kirk; Steplowski, Emily; Visvanathan, Kala; Yu, Kai; Zeleniuch-Jacquotte, Anne; Gao, Yu-Tang; Hankinson, Susan E.; Harvey, Chinonye; Hayes, Richard B.; Henderson, Brian E.; Horst, Ronald L.; Helzlsouer, Kathy J.

    2010-01-01

    A role for vitamin D in ovarian cancer etiology is supported by ecologic studies of sunlight exposure, experimental mechanism studies, and some studies of dietary vitamin D intake and genetic polymorphisms in the vitamin D receptor. However, few studies have examined the association of circulating 25-hydroxyvitamin D (25(OH)D), an integrated measure of vitamin D status, with ovarian cancer risk. A nested case-control study was conducted among 7 prospective studies to evaluate the circulating 25(OH)D concentration in relation to epithelial ovarian cancer risk. Logistic regression models were used to estimate odds ratios and 95% confidence intervals among 516 cases and 770 matched controls. Compared with 25(OH)D concentrations of 50–<75 nmol/L, no statistically significant associations were observed for <37.5 (odds ratio (OR) = 1.21, 95% confidence interval (CI): 0.87, 1.70), 37.5–<50 (OR = 1.03, 95% CI: 0.75, 1.41), or ≥75 (OR = 1.11, 95% CI: 0.79, 1.55) nmol/L. Analyses stratified by tumor subtype, age, body mass index, and other variables were generally null but suggested an inverse association between 25(OH)D and ovarian cancer risk among women with a body mass index of ≥25 kg/m2 (Pinteraction < 0.01). In conclusion, this large pooled analysis did not support an overall association between circulating 25(OH)D and ovarian cancer risk, except possibly among overweight women. PMID:20562186

  20. Measles virus genotypes circulating in India, 2011-2015.

    Science.gov (United States)

    Vaidya, Sunil R; Chowdhury, Deepika T

    2017-05-01

    The Government of India is accepted to participate in the measles elimination and rubella control goal 2020, hence genetic characterization of measles viruses (MeV) becomes essential. At National Reference Laboratory (National Institute of Virology, Pune), the throat swabs/urine specimens (n = 380) or PCR products (n = 219) obtained from the suspected measles cases were referred for the molecular testing and subsequently, MeV nucleoprotein (N) gene sequencing/genotyping. In addition, 2,449 suspected measles cases, mainly from the Maharashtra state were referred for the laboratory diagnosis. A detailed study was performed on N gene sequences obtained during last two decades. Indian MeV sequences obtained during 2011-2015 were compared with 1996-2010 sequences and genetic divergence was studied. Circulation of measles genotypes B3 (n = 3), D4 (n = 49), and D8 (n = 351) strains were observed in 19 States and three Union Territories of India. In addition, 64 measles viruses were isolated from 253 throat swab or urine specimens obtained from the suspected measles cases. During 2011-2015, 67.9% (1,663/2,449) suspected measles cases were laboratory confirmed. Molecular studies showed circulation of measles genotype B3 in India along with prominently circulating genotypes D4 and D8 except D7 strains. The genetic diversion within Indian B3, D4, and D8 genotypes was 0.3%, 1.1%, and 2.1%, respectively. The genetic divergence of Indian B3, D4, and D8 measles strains with the WHO reference sequences was 2.5%, 2.6%, and 1.8%, respectively. It is crucial data for national immunization program. More measles/rubella genotyping studies are necessary to track transmission and to support measles elimination and rubella control. J. Med. Virol. 89:753-758, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  1. On the Planning and Design of Hospital Circulation Zones.

    Science.gov (United States)

    Jiang, Shan; Verderber, Stephen

    2017-01-01

    This present literature review explores current issues and research inconsistencies regarding the design of hospital circulation zones and the associated health-related outcomes. Large general hospitals are immense, highly sophisticated institutions. Empirical studies have indicated excessively institutional environments in large medical centers are a cause of negative effects to occupants, including stress, anxiety, wayfinding difficulties and spatial disorientation, lack of cognitional control, and stress associated with inadequate access to nature. The rise of patient-centered and evidence-based movements in healthcare planning and design has resulted in a general rise in the quality of hospital physical environments. However, as a core component of any healthcare delivery system, hospital circulation zones have tended to remain neglected within the comparatively broad palette of research conducted and reported to date. A systematic literature review was conducted based upon combinations of key words developed vis-à-vis a literature search in 11 major databases in the realm of the health sciences and the planning and design of built environments for healthcare. Eleven peer-reviewed articles were included in the analysis. Six research themes were identified according to associated health-related outcomes, including wayfinding difficulties and spatial disorientation, communication and socialization patterns, measures and control of excessive noise, patient fall incidents, and occupants' stress and satisfaction levels. Several knowledge gaps as well as commonalities in the pertinent research literature were identified. Perhaps the overriding finding is that occupants' meaningful exposure to views of nature from within hospital circulation zones can potentially enhance wayfinding and spatial navigation. Future research priories on this subject are discussed.

  2. Oxidative burst of circulating neutrophils following traumatic brain injury in human.

    Directory of Open Access Journals (Sweden)

    Yiliu Liao

    Full Text Available Besides secondary injury at the lesional site, Traumatic brain injury (TBI can cause a systemic inflammatory response, which may cause damage to initially unaffected organs and potentially further exacerbate the original injury. Here we investigated plasma levels of important inflammatory mediators, oxidative activity of circulating leukocytes, particularly focusing on neutrophils, from TBI subjects and control subjects with general trauma from 6 hours to 2 weeks following injury, comparing with values from uninjured subjects. We observed increased plasma level of inflammatory cytokines/molecules TNF-α, IL-6 and CRP, dramatically increased circulating leukocyte counts and elevated expression of TNF-α and iNOS in circulating leukocytes from TBI patients, which suggests a systemic inflammatory response following TBI. Our data further showed increased free radical production in leukocyte homogenates and elevated expression of key oxidative enzymes iNOS, COX-2 and NADPH oxidase (gp91(phox in circulating leukocytes, indicating an intense induction of oxidative burst following TBI, which is significantly greater than that in control subjects with general trauma. Furthermore, flow cytometry assay proved neutrophils as the largest population in circulation after TBI and showed significantly up-regulated oxidative activity and suppressed phagocytosis rate for circulating neutrophils following brain trauma. It suggests that the highly activated neutrophils might play an important role in the secondary damage, even outside the injured brain. Taken together, the potent systemic inflammatory response induced by TBI, especially the intensively increase oxidative activity of circulating leukocytes, mainly neutrophils, may lead to a systemic damage, dysfunction/damage of bystander tissues/organs and even further exacerbate secondary local damage. Controlling these pathophysiological processes may be a promising therapeutic strategy and will protect unaffected

  3. Domestic appliances energy optimization with model predictive control

    International Nuclear Information System (INIS)

    Rodrigues, E.M.G.; Godina, R.; Pouresmaeil, E.; Ferreira, J.R.; Catalão, J.P.S.

    2017-01-01

    Highlights: • An alternative power management control for home appliances that require thermal regulation is presented. • A Model Predictive Control scheme is assessed and its performance studied and compared to the thermostat. • Problem formulation is explored through tuning weights with the aim of reducing energetic consumption and cost. • A modulation scheme of a two-level Model Predictive Control signal as an interface block is presented. • The implementation costs in home appliances with thermal regulation requirements are reduced. - Abstract: A vital element in making a sustainable world is correctly managing the energy in the domestic sector. Thus, this sector evidently stands as a key one for to be addressed in terms of climate change goals. Increasingly, people are aware of electricity savings by turning off the equipment that is not been used, or connect electrical loads just outside the on-peak hours. However, these few efforts are not enough to reduce the global energy consumption, which is increasing. Much of the reduction was due to technological improvements, however with the advancing of the years new types of control arise. Domestic appliances with the purpose of heating and cooling rely on thermostatic regulation technique. The study in this paper is focused on the subject of an alternative power management control for home appliances that require thermal regulation. In this paper a Model Predictive Control scheme is assessed and its performance studied and compared to the thermostat with the aim of minimizing the cooling energy consumption through the minimization of the energy cost while satisfying the adequate temperature range for the human comfort. In addition, the Model Predictive Control problem formulation is explored through tuning weights with the aim of reducing energetic consumption and cost. For this purpose, the typical consumption of a 24 h period of a summer day was simulated a three-level tariff scheme was used. The new

  4. Observations of the summer Red Sea circulation

    Science.gov (United States)

    Sofianos, Sarantis S.; Johns, William E.

    2007-06-01

    Aiming at exploring and understanding the summer circulation in the Red Sea, a cruise was conducted in the basin during the summer of 2001 involving hydrographic, meteorological, and direct current observations. The most prominent feature, characteristic of the summer circulation and exchange with the Indian Ocean, is a temperature, salinity, and oxygen minimum located around a depth of 75 m at the southern end of the basin, associated with Gulf of Aden Intermediate Water inflowing from the Gulf of Aden during the summer season as an intruding subsurface layer. Stirring and mixing with ambient waters lead to marked increases in temperature (from 16.5 to almost 33°C) and salinity (from 35.7 to more than 38 psu) in this layer by the time it reaches midbasin. The observed circulation presents a very vigorous pattern with strong variability and intense features that extend the width of the basin. A permanent cyclone, detected in the northern Red Sea, verifies previous observations and modeling studies, while in the central sector of the basin a series of very strong anticyclones were observed with maximum velocities exceeding 1 m/s. The three-layer flow pattern, representative of the summer exchange between the Red Sea and the Gulf of Aden, is observed in the strait of Bab el Mandeb. In the southern part of the basin the layer flow is characterized by strong banking of the inflows and outflows against the coasts. Both surface and intermediate water masses involved in the summer Red Sea circulation present prominent spatial variability in their characteristics, indicating that the eddy field and mixing processes play an important role in the summer Red Sea circulation.

  5. Decontamination of CAGR gas circulator components

    International Nuclear Information System (INIS)

    Rogers, L.N.; Hooper, A.J.

    1985-01-01

    This paper describes the development and full-scale trial of two methods for removal of radioactive contamination on the surfaces of CAGR gas circulator components. The two methods described are a particle impact cleaning (PIC) decontamination technique and an electrochemical technique, 'electro-swabbing', which is based on the principle of decontamination by electro-polishing. In developing these techniques it was necessary to take account of the physical and chemical nature of the surface deposits on the gas circulator components; these were shown to consist of magnetite-type oxide and carbonaceous material. In order to follow the progress of the decontamination it was also necessary to develop a surface sampling technique which was effective and precise under these conditions; an electrochemical technique, employing similar principles to the electro-swabbing process, was developed for this purpose. The full-scale trial of the PIC decontamination technique was carried out on an inlet guide vane (IGV) assembly, this having been identified as the component from the gas circulator which contributes most to the radiation dose accumulated during routine circulator maintenance. The technique was shown to be practically viable and some 99% of the radioactive contamination was readily removed from the treated surfaces with only negligible surface damage being caused. The full-scale trial of the electro-swabbing decontamination technique was carried out on a gas circulator impeller. High decontamination factors were again achieved with ≥ 99% of the radioactive contamination being removed from the treated surfaces. The technique has practical limitations in terms of handling and treatment of waste-arisings. However, the use of specially-designed swabbing electrodes may allow the treatment of constricted geometries inaccessible to techniques such as PIC. The technique is also highly suitable for the treatment of soft-finish materials and of components fabricated from a

  6. Circulating tocopherols and risk of coronary artery disease: A systematic review and meta-analysis.

    Science.gov (United States)

    Li, Guangxiao; Li, Ying; Chen, Xin; Sun, Hao; Hou, Xiaowen; Shi, Jingpu

    2016-05-01

    Circulating level of tocopherols was supposed to be associated with risk of coronary artery disease. However, the results from previous studies remain controversial. Therefore, we conducted a meta-analysis based on observational studies to evaluate the association between circulating tocopherols and coronary artery disease risk for the first time. Meta-analysis. PubMed, Embase and Cochrane databases were searched to retrieve articles published during January 1995 and May 2015. Articles were included if they provided sufficient information to calculate the weighted mean difference and its corresponding 95% confidence interval. Circulating level of total tocopherols was significantly lower in coronary artery disease patients than that in controls (weighted mean difference -4.33 μmol/l, 95% confidence interval -6.74 to -1.91, P tocopherol alone was not significantly associated with coronary artery disease risk. Results from subgroup analyses showed that a lower level of circulating total tocopherols was merely associated with higher coronary artery disease risk in studies with higher sex ratio in cases (tocopherols was associated with early onset coronary artery disease rather than late onset coronary artery disease (tocopherols when the studies were stratified by matching status and assay methods. Our findings suggest that a deficiency in circulating total tocopherols might be associated with higher coronary artery disease risk. Whereas circulating α-tocopherol alone could not protect us from developing coronary artery disease. Further prospective studies were warranted to confirm our findings. © The European Society of Cardiology 2015.

  7. Circulating DNA and its methylation level in inflammatory bowel disease and related colon cancer.

    Science.gov (United States)

    Bai, Xuming; Zhu, Yaqun; Pu, Wangyang; Xiao, Li; Li, Kai; Xing, Chungen; Jin, Yong

    2015-01-01

    Both of chronic inflammation and abnormal immune in inflammatory bowel disease can induce colon cancer. Previous research showed that cell apoptosis and necrosis become the main source of circulating DNA in the peripheral blood during tumorigenesis that reduced along with methylation degree. However, its role in the process of colitis transforming to colon cancer is not clarified. Drinking 3% DSS was used to establish colitis model, while 3% dextran sodium sulfate (DSS) combined with azo oxidation methane (AOM) intraperitoneal injection was applied to establish colitis related colon cancer model. Circulating DNA and its methylation level in peripheral blood were tested. Morphology observation, HE staining, and p53 and β-catenin expression detection confirmed that drinking 3% DSS and 3% DSS combined with AOM intraperitoneal injection can successfully establish colitis and colitis associated colorectal cancer models. Circulating DNA level in colitis and colon cancer mice increased by gradient compared with control, while significant difference was observed between each other. Circulating DNA methylation level decreased obviously in colitis and colon cancer, and significant difference was observed between each other. Abnormal protein expression, circulating DNA and its methylation level in ulcerative colitis associated colorectal tissues change in gradient, suggesting that circulating DNA and its methylation level can be treated as new markers for colitis cancer transformation that has certain significance to explore the mechanism of human ulcerative colitis canceration.

  8. Differential adipokine receptor expression on circulating leukocyte subsets in lean and obese children.

    Directory of Open Access Journals (Sweden)

    Genoveva Keustermans

    Full Text Available Childhood obesity prevalence has increased worldwide and is an important risk factor for type 2 diabetes (T2D and cardiovascular disease (CVD. The production of inflammatory adipokines by obese adipose tissue contributes to the development of T2D and CVD. While levels of circulating adipokines such as adiponectin and leptin have been established in obese children and adults, the expression of adiponectin and leptin receptors on circulating immune cells can modulate adipokine signalling, but has not been studied so far. Here, we aim to establish the expression of adiponectin and leptin receptors on circulating immune cells in obese children pre and post-lifestyle intervention compared to normal weight control children.13 obese children before and after a 1-year lifestyle intervention were compared with an age and sex-matched normal weight control group of 15 children. Next to routine clinical and biochemical parameters, circulating adipokines were measured, and flow cytometric analysis of adiponectin receptor 1 and 2 (AdipoR1, AdipoR2 and leptin receptor expression on peripheral blood mononuclear cell subsets was performed.Obese children exhibited typical clinical and biochemical characteristics compared to controls, including a higher BMI-SD, blood pressure and circulating leptin levels, combined with a lower insulin sensitivity index (QUICKI. The 1-year lifestyle intervention resulted in stabilization of their BMI-SD. Overall, circulating leukocyte subsets showed distinct adipokine receptor expression profiles. While monocytes expressed high levels of all adipokine receptors, NK and iNKT cells predominantly expressed AdipoR2, and B-lymphocytes and CD4+ and CD8+ T-lymphocyte subsets expressed AdipoR2 as well as leptin receptor. Strikingly though, leukocyte subset numbers and adipokine receptor expression profiles were largely similar in obese children and controls. Obese children showed higher naïve B-cell numbers, and pre-intervention also

  9. A potential of boiling water power reactors with a natural circulation of a coolant

    International Nuclear Information System (INIS)

    Osmachkin, V.S.; Sokolov, I.N.

    1998-01-01

    The use of the natural circulation of coolant in the boiling water reactors simplifies a reactor control and facilities the service of the equipment components. The moderated core power loads allows the long fuel burnup, good control ability and large water stock set up the enhancement of safety level. That is considered to be very important for isolated regions or small countries. In the paper a high safety level and effectiveness of BWRs with natural circulation are reviewed. The limitations of flow stability and protection measures are being discussed. Some recent efforts in designing of such reactors are described.(author)

  10. Effect of circulation on wastewater treatment by Lemna gibba and Lemna minor (floating aquatic macrophytes).

    Science.gov (United States)

    Demirezen Yilmaz, Dilek; Akbulut, Hatice

    2011-01-01

    In this study, laboratory tests were performed in order to examine growth characteristics of floating aquatic macrophytes (Lemna gibba and Lemna minor) in the presence of wastewater with circulation. The results showed that circulation of the waste water enhanced the kinetics of the process, as compared to the control systems. However, prolonged application of high circulation level had a different effect. In the presence of circulation with aquatic plants, there was additional 85.3-88.2% for BODs and 59.6-66.8% for COD decreases in the water quality indicators. In this study, the effectiveness of L. gibba and L. minor with circulation addition for the removal of four heavy metals (Pb, Ni, Mn, and Cu) from waste water was also investigated. Results from analysis confirmed the accumulation of different metals within the plant and a corresponding decrease of metals in the waste water. At the end of the study of circulation, L. gibba provided the metal removal for Cu, Pb, Ni, and Mn in the waste water as the ratio of 57%, 60%, 60%, and 62%, respectively. In this context, the best results were obtained when the action of L. gibba and L. minor plants, was combined with that of circulation. It is shown that in the presence of L. gibba and L. minor plants that are supplemented with circulation, the national standards of biochemical oxygen demand (BOD5) 27-33 mgL(-1) and chemical oxygen demand (COD) 62-78 mgL(-1) for L. minor and L. gibba, respectively, were reached after treatment. The new results can be used for design calculations regarding expected removal of pollutants by aquatic floating plants.

  11. Could circulating fetuin A be a biomarker of aortic valve stenosis?

    Science.gov (United States)

    Di Minno, Alessandro; Zanobini, Marco; Myasoedova, Veronika A; Valerio, Vincenza; Songia, Paola; Saccocci, Matteo; Di Minno, Matteo Nicola Dario; Tremoli, Elena; Poggio, Paolo

    2017-12-15

    Aortic valve stenosis (AVS) is a multifactorial-progressive pathological process. In the past decades, many studies have focus their attention on circulating biomarkers able to identify AVS and/or to predict its progression. One of the many biomarkers studied is the fetuin A. The aim of the present meta-analysis was to evaluate the correlation between fetuin A levels and end-stage AVS. A systematic search was performed in three electronic databases (PubMed, Web of Science and Scopus), looking for studies that compared control subjects with AVS patients and that have measured fetuin A circulating levels in both groups. The main outcome was to evaluate the difference in circulating fetuin A concentration in the two groups. Seven studies, enrolling 2283 AVS patients and 1549 controls, were included. Differences between control subjects and AVS patients were expressed as standardized mean difference (SMD) with pertinent 95% confidence intervals (95%CI) and standard deviation (SD), analysing the data using a random effect model. We found significantly lower circulating levels of fetuin A in AVS patients compared to healthy subjects (SMD: -0.96μg/mL, 95% CI: -1.62, -0.30; p=0.004). In addition, meta-regression analyses showed that several cardiovascular risk factors were significantly associated with circulating levels of fetuin A between patients affected by AVS and healthy controls. In conclusion, our meta-analysis shows that AVS patients have significant lower circulating levels of fetuin A compared to control subjects. However, dedicated studies with large and matched cohorts are needed to validate these findings, evaluating if there is a real link or just a mere association. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Experimental investigation on natural circulation and air-injection enhanced circulation in a simple loop

    International Nuclear Information System (INIS)

    Walter Ambrosini; Nicola Forgione; Francesco Oriolo; Filippo Pellacani; Mariano Tarantino; Claudio Struckmann

    2005-01-01

    Full text of publication follows: Natural circulation represents an interesting phenomenon because of both the complex aspects characterising it and for the widespread application in industry. On the other hand, injection of a gas into a rising branch of a loop represents a means to establish or to enhance a circulation flow, as it occurs in the so-called 'air-lift' loops. Both natural circulation and gas-injection enhanced circulation are presently considered for cooling Accelerator Driven System (ADS) reactors. These are subcritical reactors in which the fission reaction chain is maintained by the injection of neutrons obtained by spallation reactions in a target through a high energy proton beam generated in an external accelerator. The capability of such reactors to be used as incinerators of long lived fission products makes them particularly interesting in the light of the closure of the nuclear fuel cycle. Some of the fluids proposed as coolants for these reactors are liquid metals, with main interest for lead and lead-bismuth eutectic (LBE). Experimental activities are being performed in support to the design of the reactor prototype by different organisations. The university of Pisa, in addition to provide cooperation in these large scale activities performed with LBE has set up a specific experimental program aimed at studying the fundamental mechanisms involved in natural circulation and gas-injection enhanced circulation. The adopted experimental facility consists in a simple loop, having a rectangular lay-out (roughly, 4 m tall and 1 m wide), equipped with a 5 kW, 1 m tall heater, a 2 m long pipe-in-pipe heat exchanger, an air injection device and a separator. The fluid adopted in the tests performed up to now is water, though studies for evaluating the feasibility of the adoption of different fluids have been undertaken. Experimental data reported in previous publications concerning this research were related to a relatively high range of gas

  13. Defective Circulating Regulatory B Cells in Patients with Dilated Cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Jiao Jiao

    2018-03-01

    Full Text Available Background/Aims: Newly identified IL-10-producing regulatory B cells (Bregs have been shown to play an important role in the suppression of immune responses. Chronic immune activation participates in the pathogenesis of dilated cardiomyopathy (DCM but whether Bregs are involved in its development remains unclear. We aimed to investigate the circulating frequency and function of Bregs in DCM. Methods: In total, 35 DCM patients (20 men and 15 women and 44 healthy controls (23 men and 21 women were included in the experiment, and the frequency of Bregs was detected using flow cytometry. Results: According to our results, the frequency of circulating IL-10-producing Bregs was significantly lower in DCM patients compared with healthy controls. Furthermore, the CD24hiCD27+ B cell subset in which IL-10-producing Bregs were mainly enriched from DCM patients showed impaired IL-10 expression and a decreased ability to suppress the TNF-α production of CD4+CD25- Tconv cells and to maintain Tregs differentiation. Correlation analysis showed that the frequency of IL-10-producing Bregs and the suppressive function of CD24hiCD27+ B cells were positively correlated with left ventricular ejection fraction and negatively correlated with NT-proBNP in DCM patients. Conclusions: In conclusion, the reduced frequency and impaired functions suggest a potential role of Bregs in the development of DCM.

  14. Circulating neutrophil transcriptome may reveal intracranial aneurysm signature.

    Directory of Open Access Journals (Sweden)

    Vincent M Tutino

    Full Text Available Unruptured intracranial aneurysms (IAs are typically asymptomatic and undetected except for incidental discovery on imaging. Blood-based diagnostic biomarkers could lead to improvements in IA management. This exploratory study examined circulating neutrophils to determine whether they carry RNA expression signatures of IAs.Blood samples were collected from patients receiving cerebral angiography. Eleven samples were collected from patients with IAs and 11 from patients without IAs as controls. Samples from the two groups were paired based on demographics and comorbidities. RNA was extracted from isolated neutrophils and subjected to next-generation RNA sequencing to obtain differential expressions for identification of an IA-associated signature. Bioinformatics analyses, including gene set enrichment analysis and Ingenuity Pathway Analysis, were used to investigate the biological function of all differentially expressed transcripts.Transcriptome profiling identified 258 differentially expressed transcripts in patients with and without IAs. Expression differences were consistent with peripheral neutrophil activation. An IA-associated RNA expression signature was identified in 82 transcripts (p<0.05, fold-change ≥2. This signature was able to separate patients with and without IAs on hierarchical clustering. Furthermore, in an independent, unpaired, replication cohort of patients with IAs (n = 5 and controls (n = 5, the 82 transcripts separated 9 of 10 patients into their respective groups.Preliminary findings show that RNA expression from circulating neutrophils carries an IA-associated signature. These findings highlight a potential to use predictive biomarkers from peripheral blood samples to identify patients with IAs.

  15. Circulating neutrophil transcriptome may reveal intracranial aneurysm signature

    Science.gov (United States)

    Tutino, Vincent M.; Poppenberg, Kerry E.; Jiang, Kaiyu; Jarvis, James N.; Sun, Yijun; Sonig, Ashish; Siddiqui, Adnan H.; Snyder, Kenneth V.; Levy, Elad I.; Kolega, John

    2018-01-01

    Background Unruptured intracranial aneurysms (IAs) are typically asymptomatic and undetected except for incidental discovery on imaging. Blood-based diagnostic biomarkers could lead to improvements in IA management. This exploratory study examined circulating neutrophils to determine whether they carry RNA expression signatures of IAs. Methods Blood samples were collected from patients receiving cerebral angiography. Eleven samples were collected from patients with IAs and 11 from patients without IAs as controls. Samples from the two groups were paired based on demographics and comorbidities. RNA was extracted from isolated neutrophils and subjected to next-generation RNA sequencing to obtain differential expressions for identification of an IA-associated signature. Bioinformatics analyses, including gene set enrichment analysis and Ingenuity Pathway Analysis, were used to investigate the biological function of all differentially expressed transcripts. Results Transcriptome profiling identified 258 differentially expressed transcripts in patients with and without IAs. Expression differences were consistent with peripheral neutrophil activation. An IA-associated RNA expression signature was identified in 82 transcripts (pIAs on hierarchical clustering. Furthermore, in an independent, unpaired, replication cohort of patients with IAs (n = 5) and controls (n = 5), the 82 transcripts separated 9 of 10 patients into their respective groups. Conclusion Preliminary findings show that RNA expression from circulating neutrophils carries an IA-associated signature. These findings highlight a potential to use predictive biomarkers from peripheral blood samples to identify patients with IAs. PMID:29342213

  16. Money circulation and debt circulation: A restatement of quantity theory of money

    OpenAIRE

    Xing, Xiaoyun; Xiong, Wanting; Chen, Liujun; Chen, Jiawei; Wang, Yougui; Stanley, H. Eugene

    2018-01-01

    Both money and debt are products of credit creation of banks. Money is always circulating among traders by facilitating commodity transactions. In contrast, debt is created by borrowing and annihilated by repayment as it is matured. However, when this creation- annihilation process is mediated by banks which are constrained by a credit capacity, there exists continuous transfer of debt among debtors, which can be defined as debt circulation. This paper presents a multi-agent model in which in...

  17. Dynamic simulation of a forced circulation evaporating system

    International Nuclear Information System (INIS)

    Lee, J.S.; Lee, K.J.

    1993-01-01

    A dynamic simulation program has been developed to simulate the forced circulation evaporating system of the Kori PWR Power Plant in Korea which is used to treat liquid waste containing boric acid. Energy and mass balances for the vapor and liquid phases are used to describe the interaction among system components such as the vapor body, heater jacket and condenser. In order to simulate entrainment carryover in the sieve tray column and wire mesh pad, Kister's and Carpenter-Othmer's correlations are adopted, respectively. A new correlation formula is also suggested to simulate the geometric effect of the vapor body. A fuzzy heuristic controller and conventional controllers such as P (proportional), PI (proportional-integral) and PID (proportional-integral-derivative) controls are incorporated to observe their responses to a given disturbance. The simulations show good agreement with the real operation data. It is also identified that the vapor velocity or flow rate in the sieve tray column determines the system decontamination factor (DF), and that the longer the vapor body is, the less entrainment carryover occurs out of the vapor body. In addition, the wire mesh pad is identified as maintaining very high deentrainment efficiency even though the vapor velocity may show large fluctuations. With respect to system control, the fuzzy heuristic controller approaches a new steady state faster than conventional controllers. Also the fuzzy controller maintains higher DF during transients and is stronger against time delay in the control components. (Author)

  18. Perks of controlled circ: a case study of the distribution practices of Vancouver and Western Living magazines

    OpenAIRE

    Law, Melanie

    2007-01-01

    This report examines controlled-circulation magazines using Vancouver and Western Living magazines as successful examples. It provides an analysis of the workings of controlled circulation with reference to advertising, editorial, branding, and operations, and shows how magazines with this distribution method can be successful despite publishing professionals’ common assumption that controlled-circulation magazines are of lesser quality than paid-circulation magazines.

  19. The impact of the ocean observing system on estimates of the California current circulation spanning three decades

    Science.gov (United States)

    Moore, Andrew M.; Jacox, Michael G.; Crawford, William J.; Laughlin, Bruce; Edwards, Christopher A.; Fiechter, Jérôme

    2017-08-01

    Data assimilation is now used routinely in oceanography on both regional and global scales for computing ocean circulation estimates and for making ocean forecasts. Regional ocean observing systems are also expanding rapidly, and observations from a wide array of different platforms and sensor types are now available. Evaluation of the impact of the observing system on ocean circulation estimates (and forecasts) is therefore of considerable interest to the oceanographic community. In this paper, we quantify the impact of different observing platforms on estimates of the California Current System (CCS) spanning a three decade period (1980-2010). Specifically, we focus attention on several dynamically related aspects of the circulation (coastal upwelling, the transport of the California Current and the California Undercurrent, thermocline depth and eddy kinetic energy) which in many ways describe defining characteristics of the CCS. The circulation estimates were computed using a 4-dimensional variational (4D-Var) data assimilation system, and our analyses also focus on the impact of the different elements of the control vector (i.e. the initial conditions, surface forcing, and open boundary conditions) on the circulation. While the influence of each component of the control vector varies between different metrics of the circulation, the impact of each observing system across metrics is very robust. In addition, the mean amplitude of the circulation increments (i.e. the difference between the analysis and background) remains relatively stable throughout the three decade period despite the addition of new observing platforms whose impact is redistributed according to the relative uncertainty of observations from each platform. We also consider the impact of each observing platform on CCS circulation variability associated with low-frequency climate variability. The low-frequency nature of the dominant climate modes in this region allows us to track through time the

  20. Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance.

    Directory of Open Access Journals (Sweden)

    José María Moreno-Navarrete

    Full Text Available Zonulin is the only physiological mediator known to regulate intestinal permeability reversibly by modulating intercellular tight junctions. To investigate the relationship between intestinal permeability and obesity-associated metabolic disturbances in humans, we aimed to study circulating zonulin according to obesity and insulin resistance. Circulating zonulin (ELISA was measured in 123 caucasian men in association with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity. Circulating zonulin increased with body mass index (BMI, waist to hip ratio (WHR, fasting insulin, fasting triglycerides, uric acid and IL-6, and negatively correlated with HDL-cholesterol and insulin sensitivity. In multiple regression analysis, insulin sensitivity (p = 0.002 contributed independently to circulating zonulin variance, after controlling for the effects of BMI, fasting triglycerides and age. When circulating IL-6 was added to this model, only BMI (p = 0.01 contributed independently to circulating zonulin variance. In conclusion, the relationship between insulin sensitivity and circulating zonulin might be mediated through the obesity-related circulating IL-6 increase.

  1. Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance.

    Science.gov (United States)

    Moreno-Navarrete, José María; Sabater, Mònica; Ortega, Francisco; Ricart, Wifredo; Fernández-Real, José Manuel

    2012-01-01

    Zonulin is the only physiological mediator known to regulate intestinal permeability reversibly by modulating intercellular tight junctions. To investigate the relationship between intestinal permeability and obesity-associated metabolic disturbances in humans, we aimed to study circulating zonulin according to obesity and insulin resistance. Circulating zonulin (ELISA) was measured in 123 caucasian men in association with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity). Circulating zonulin increased with body mass index (BMI), waist to hip ratio (WHR), fasting insulin, fasting triglycerides, uric acid and IL-6, and negatively correlated with HDL-cholesterol and insulin sensitivity. In multiple regression analysis, insulin sensitivity (p = 0.002) contributed independently to circulating zonulin variance, after controlling for the effects of BMI, fasting triglycerides and age. When circulating IL-6 was added to this model, only BMI (p = 0.01) contributed independently to circulating zonulin variance. In conclusion, the relationship between insulin sensitivity and circulating zonulin might be mediated through the obesity-related circulating IL-6 increase.

  2. Atmospheric circulation in regional climate models over Central Europe: links to surface air temperature and the influence of driving data

    International Nuclear Information System (INIS)

    Plavcova, Eva; Kysely, Jan

    2012-01-01

    The study examines simulation of atmospheric circulation, represented by circulation indices (flow direction, strength and vorticity), and links between circulation and daily surface air temperatures in regional climate models (RCMs) over Central Europe. We explore control simulations of five high-resolution RCMs from the ENSEMBLES project driven by re-analysis (ERA-40) and the same global climate model (ECHAM5 GCM) plus of one RCM (RCA) driven by different GCMs. The aims are to (1) identify errors in RCM-simulated distributions of circulation indices in individual seasons, (2) identify errors in simulated temperatures under particular circulation indices, and (3) compare performance of individual RCMs with respect to the driving data. Although most of the RCMs qualitatively reflect observed distributions of the airflow indices, each produces distributions significantly different from the observations. General biases include overestimation of the frequency of strong flow days and of strong cyclonic vorticity. Some circulation biases obviously propagate from the driving data. ECHAM5 and all simulations driven by ECHAM5 underestimate frequency of easterly flow, mainly in summer. Except for HIRHAM, however, all RCMs driven by ECHAM5 improve on the driving GCM in simulating atmospheric circulation. The influence on circulation characteristics in the nested RCM differs between GCMs, as demonstrated in a set of RCA simulations with different driving data. The driving data control on circulation in RCA is particularly weak for the BCM GCM, in which case RCA substantially modifies (but does not improve) the circulation from the driving data in both winter and summer. Those RCMs with the most distorted atmospheric circulation are HIRHAM driven by ECHAM5 and RCA driven by BCM. Relatively strong relationships between circulation indices and surface air temperatures were found in the observed data for Central Europe. The links differ by season and are usually stronger for

  3. Atmospheric circulation in regional climate models over Central Europe: links to surface air temperature and the influence of driving data

    Energy Technology Data Exchange (ETDEWEB)

    Plavcova, Eva [Institute of Atmospheric Physics, Academy of Sciences of the Czech Republic, Prague 4 (Czech Republic); Technical University, Department of Applied Mathematics, Liberec (Czech Republic); Charles University, Faculty of Mathematics and Physics, Prague (Czech Republic); Kysely, Jan [Institute of Atmospheric Physics, Academy of Sciences of the Czech Republic, Prague 4 (Czech Republic); Technical University, Department of Applied Mathematics, Liberec (Czech Republic)

    2012-10-15

    The study examines simulation of atmospheric circulation, represented by circulation indices (flow direction, strength and vorticity), and links between circulation and daily surface air temperatures in regional climate models (RCMs) over Central Europe. We explore control simulations of five high-resolution RCMs from the ENSEMBLES project driven by re-analysis (ERA-40) and the same global climate model (ECHAM5 GCM) plus of one RCM (RCA) driven by different GCMs. The aims are to (1) identify errors in RCM-simulated distributions of circulation indices in individual seasons, (2) identify errors in simulated temperatures under particular circulation indices, and (3) compare performance of individual RCMs with respect to the driving data. Although most of the RCMs qualitatively reflect observed distributions of the airflow indices, each produces distributions significantly different from the observations. General biases include overestimation of the frequency of strong flow days and of strong cyclonic vorticity. Some circulation biases obviously propagate from the driving data. ECHAM5 and all simulations driven by ECHAM5 underestimate frequency of easterly flow, mainly in summer. Except for HIRHAM, however, all RCMs driven by ECHAM5 improve on the driving GCM in simulating atmospheric circulation. The influence on circulation characteristics in the nested RCM differs between GCMs, as demonstrated in a set of RCA simulations with different driving data. The driving data control on circulation in RCA is particularly weak for the BCM GCM, in which case RCA substantially modifies (but does not improve) the circulation from the driving data in both winter and summer. Those RCMs with the most distorted atmospheric circulation are HIRHAM driven by ECHAM5 and RCA driven by BCM. Relatively strong relationships between circulation indices and surface air temperatures were found in the observed data for Central Europe. The links differ by season and are usually stronger for

  4. Modelling the Seasonal Overturning Circulation in the Red Sea

    KAUST Repository

    Yao, Fengchao; Hoteit, Ibrahim; Pratt, Larry; Bower, Amy; Koehl, Armin; Gopalakrishnan, Ganesh

    2015-01-01

    The overturning circulation in the Red Sea exhibits a distinct seasonally reversing pattern and is studied using 50-year, high-resolution MIT general circulation model simulations. The seasonal water exchange in the Strait of Bab el Mandeb

  5. Silent Circulation of Ross River Virus in French Polynesia

    Directory of Open Access Journals (Sweden)

    Maite Aubry

    2015-08-01

    Discussion: Our results support the existence of autochthonous RRV transmission and suggest that this pathogen has silently circulated in French Polynesia. These findings raise the question of possible undetected circulation of RRV in other Pacific Island Countries and Territories.

  6. Circulating dendritic cells in pediatric patients with nephrotic syndrome

    African Journals Online (AJOL)

    EL-HAKIM

    nephrotic syndrome, circulating DCs were measured by flowcytometry. Results: Circulating DC count ... parents or caregivers of each child before enrollment in the study. ..... role in initiating the primary immune response. On the basis of the ...

  7. Distinct proteome pathology of circulating microparticles in systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Østergaard, Ole; Nielsen, Christoffer Tandrup; Tanassi, Julia T

    2017-01-01

    BACKGROUND: The pathogenesis of systemic lupus erythematosus (SLE) is poorly understood but has been linked to defective clearance of subcellular particulate material from the circulation. This study investigates the origin, formation, and specificity of circulating microparticles (MPs) in patients...

  8. Circulation induced by diffused aeration in a shallow lake

    African Journals Online (AJOL)

    2017-01-01

    Jan 1, 2017 ... Lastly, a simple returning flow model was proposed to describe the circulation flow patterns ... method to describe the circulation patterns induced by the bub- ... 160 holes of 1 mm, which was designed to promote high mix-.

  9. Uptake and degradation of circulating proteins by the liver.

    NARCIS (Netherlands)

    Buys, Carolus Henricus Cornelis Maria

    1976-01-01

    Circulating proteins, like all proteins in a living animal, are subject to continual replacement or turnover. This process implies both synthesis and degradation, This thesis deals with the degradative part of turnover of circulating proteins. ... Summary

  10. Genetic determinants of circulating sphingolipid concentrations in European populations.

    Directory of Open Access Journals (Sweden)

    Andrew A Hicks

    2009-10-01

    Full Text Available Sphingolipids have essential roles as structural components of cell membranes and in cell signalling, and disruption of their metabolism causes several diseases, with diverse neurological, psychiatric, and metabolic consequences. Increasingly, variants within a few of the genes that encode enzymes involved in sphingolipid metabolism are being associated with complex disease phenotypes. Direct experimental evidence supports a role of specific sphingolipid species in several common complex chronic disease processes including atherosclerotic plaque formation, myocardial infarction (MI, cardiomyopathy, pancreatic beta-cell failure, insulin resistance, and type 2 diabetes mellitus. Therefore, sphingolipids represent novel and important intermediate phenotypes for genetic analysis, yet little is known about the major genetic variants that influence their circulating levels in the general population. We performed a genome-wide association study (GWAS between 318,237 single-nucleotide polymorphisms (SNPs and levels of circulating sphingomyelin (SM, dihydrosphingomyelin (Dih-SM, ceramide (Cer, and glucosylceramide (GluCer single lipid species (33 traits; and 43 matched metabolite ratios measured in 4,400 subjects from five diverse European populations. Associated variants (32 in five genomic regions were identified with genome-wide significant corrected p-values ranging down to 9.08x10(-66. The strongest associations were observed in or near 7 genes functionally involved in ceramide biosynthesis and trafficking: SPTLC3, LASS4, SGPP1, ATP10D, and FADS1-3. Variants in 3 loci (ATP10D, FADS3, and SPTLC3 associate with MI in a series of three German MI studies. An additional 70 variants across 23 candidate genes involved in sphingolipid-metabolizing pathways also demonstrate association (p = 10(-4 or less. Circulating concentrations of several key components in sphingolipid metabolism are thus under strong genetic control, and variants in these loci can be

  11. Anti-cyclonic circulation driven by the estuarine circulation in a gulf type ROFI

    Science.gov (United States)

    Fujiwara, T.; Sanford, L. P.; Nakatsuji, K.; Sugiyama, Y.

    1997-08-01

    Baroclinic residual circulation processes are examined in gulf type Regions Of Freshwater Influence (ROFIs), which have large rivers discharging into a rounded head wider than the Rossby internal deformation radius. Theoretical and observational investigations concentrate on Ise Bay, Japan, with supporting data from Osaka Bay and Tokyo Bay. Simplified analytical solutions are derived to describe the primary features of the circulation. Three dimensional residual current data collected using moored current meters and shipboard acoustic doppler current profilers (ADCPs), satellite imagery and density structure data observed using STDs, are presented for comparison to the theoretical predictions. There are three key points to understanding the resulting circulation in gulf type ROFIs. First, there are likely to be three distinct water masses: the river plume, a brackish upper layer, and a higher salinity lower layer. Second, baroclinic processes in gulf type ROFIs are influenced by the Earth's rotation at first order. Residual currents are quasi-geostrophic and potential vorticity is approximately conserved. Third, the combined effects of a classical longitudinal estuarine circulation and the Earth's rotation are both necessary to produce the resulting circulation. Anti-cyclonic vorticity is generated in the upper layer by the horizontal divergence associated with upward entrainment, which is part of the estuarine circulation. The interaction between anti-cyclonic vorticity and horizontal divergence results in two regions of qualitatively different circulation, with gyre-like circulation near the bay head and uniformly seaward anti-cyclonicly sheared flow further towards the mouth. The stagnation point separating the two regions is closer to (further away from) the bay head for stronger (weaker) horizontal divergence, respectively. The vorticity and spin-up time of this circulation are-(ƒ-ω 1)/2 and h/2w 0, respectively, where ƒ is the Coriolis parameter, ω 1 is

  12. Producing superfluid circulation states using phase imprinting

    Science.gov (United States)

    Kumar, Avinash; Dubessy, Romain; Badr, Thomas; De Rossi, Camilla; de Goër de Herve, Mathieu; Longchambon, Laurent; Perrin, Hélène

    2018-04-01

    We propose a method to prepare states of given quantized circulation in annular Bose-Einstein condensates (BEC) confined in a ring trap using the method of phase imprinting without relying on a two-photon angular momentum transfer. The desired phase profile is imprinted on the atomic wave function using a short light pulse with a tailored intensity pattern generated with a spatial light modulator. We demonstrate the realization of "helicoidal" intensity profiles suitable for this purpose. Due to the diffraction limit, the theoretical steplike intensity profile is not achievable in practice. We investigate the effect of imprinting an intensity profile smoothed by a finite optical resolution onto the annular BEC with a numerical simulation of the time-dependent Gross-Pitaevskii equation. This allows us to optimize the intensity pattern for a given target circulation to compensate for the limited resolution.

  13. Natural circulation in pressurized water reactors

    International Nuclear Information System (INIS)

    Bastos, J.L.F.; Loureiro, L.V.; Rocha, R.T.V. da; Umbehaun, P.E.

    1992-01-01

    Several analytical modelling have been done for steady-state and slow transients conditions, besides more sophisticated studies considering two and three dimensional effects in a very simple geometry. Under severe accident conditions for PWR a code to analyse natural circulation has been developed by Westinghouse. This paper discusses the problem of natural circulation in a complex geometry similar to that of nuclear power plants. A first experiment has been done at the integral test facility of 'Co-ordination of Special Projects-Ministry of Naval Affairs' (Coordenadoria para Projetos Especiais -Ministerio da Marinha, COPESP) for several flux conditions. The results obtained were compared with numerical simulations for the steady-state regime. 09 refs, 05 figs, 01 tab. (B.C.A.)

  14. Circulating elastin peptides, role in vascular pathology.

    Science.gov (United States)

    Robert, L; Labat-Robert, J

    2014-12-01

    The atherosclerotic process starts with the degradation of elastic fibers. Their presence was demonstrated in the circulation as well as several of their biological properties elucidated. We described years ago a procedure to obtain large elastin peptides by organo-alkaline hydrolysis, κ-elastin. This method enabled also the preparation of specific antibodies used to determine elastin peptides, as well as anti-elastin antibodies in body fluids and tissue extracts. Elastin peptides were determined in a large number of human blood samples. Studies were carried out to explore their pharmacological properties. Similar recent studies by other laboratories confirmed our findings and arose new interest in circulating elastin peptides for their biological activities. This recent trend justified the publication of a review of the biological and pathological activities of elastin peptides demonstrated during our previous studies, subject of this article. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  15. Natural circulation in simulated LMFBR fuel assemblies

    International Nuclear Information System (INIS)

    Levin, A.E.; Carbajo, J.J.; Lloyd, D.B.; Montgomery, B.H.; Rose, S.D.; Wantland, J.L.

    1985-01-01

    Natural circulation experiments have been performed using simulated liquid metal fast breeder reactor fuel assemblies in the Thermal-Hydraulic Out-of-Reactor Safety (THORS) facility, an engineering-scale sodium loop. Objective of these tests has been to provide experimental data under conditions that might be encountered during a partial or total loss of the shutdown heat removal system (SHRS) in a reactor. The experiments have included single- and two-phase tests under quasi-steady and transient conditions, at both nominal and non-nominal system conditions. Results from these test indicate that the potential for reactor damage during degraded SHRS operation is extremely slight, and that natural circulation can be a major contributor to safe operation of the system in both single- and two-phase flow during such operation

  16. Genetic architecture of circulating lipid levels

    DEFF Research Database (Denmark)

    Demirkan, Ayşe; Amin, Najaf; Isaacs, Aaron

    2011-01-01

    Serum concentrations of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs) and total cholesterol (TC) are important heritable risk factors for cardiovascular disease. Although genome-wide association studies (GWASs) of circulating lipid...... the ENGAGE Consortium GWAS on serum lipids, were applied to predict lipid levels in an independent population-based study, the Rotterdam Study-II (RS-II). We additionally tested for evidence of a shared genetic basis for different lipid phenotypes. Finally, the polygenic score approach was used to identify...... an alternative genome-wide significance threshold before pathway analysis and those results were compared with those based on the classical genome-wide significance threshold. Our study provides evidence suggesting that many loci influencing circulating lipid levels remain undiscovered. Cross-prediction models...

  17. Exercise increases circulating GDF15 in humans

    DEFF Research Database (Denmark)

    Kleinert, Maximilian; Clemmensen, Christoffer; Sjøberg, Kim Anker

    2018-01-01

    OBJECTIVE: The growth differentiation factor 15 (GDF15) is a stress-sensitive circulating factor that regulates systemic energy balance. Since exercise is a transient physiological stress that has pleiotropic effects on whole-body energy metabolism, we herein explored the effect of exercise on a......) circulating GDF15 levels and b) GDF15 release from skeletal muscle in humans. METHODS: Seven healthy males either rested or exercised at 67% of their VO2max for 1 h and blood was sampled from the femoral artery and femoral vein before, during, and after exercise. Plasma GDF15 concentrations were determined...... in these samples. RESULTS: Plasma GDF15 levels increased 34% with exercise (p exercise. There was no difference between the arterial and venous GDF15 concentration before, during, and after exercise. During...

  18. On-Chip Microwave Quantum Hall Circulator

    Directory of Open Access Journals (Sweden)

    A. C. Mahoney

    2017-01-01

    Full Text Available Circulators are nonreciprocal circuit elements that are integral to technologies including radar systems, microwave communication transceivers, and the readout of quantum information devices. Their nonreciprocity arises from the interference of microwaves over the centimeter scale of the signal wavelength, in the presence of bulky magnetic media that breaks time-reversal symmetry. Here, we realize a completely passive on-chip microwave circulator with size 1/1000th the wavelength by exploiting the chiral, “slow-light” response of a two-dimensional electron gas in the quantum Hall regime. For an integrated GaAs device with 330  μm diameter and about 1-GHz center frequency, a nonreciprocity of 25 dB is observed over a 50-MHz bandwidth. Furthermore, the nonreciprocity can be dynamically tuned by varying the voltage at the port, an aspect that may enable reconfigurable passive routing of microwave signals on chip.

  19. Circulating Nesfatin-1 Levels and Type 2 Diabetes: A Systematic Review and Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Ting Zhai

    2017-01-01

    Full Text Available The role of nesfatin-1 in glucose homeostasis has been investigated previously. However, although numerous studies have examined the relationships between circulating nesfatin-1 levels and type 2 diabetes, the conclusions are contradictory. We aimed to probe the relationship between circulating nesfatin-1 levels and type 2 diabetes by meta-analysis. Seven studies including 328 type 2 diabetes patients and 294 control subjects were included. Although there was no obvious difference in circulating nesfatin-1 levels between patients with type 2 diabetes and the control group (MD = −0.04; 95% CI = −0.32 to −0.23, subgroup analysis showed higher nesfatin-1 levels in newly diagnosed type 2 diabetes patients (MD = 0.59; 95% CI = 0.45 to 0.74 and significantly lower nesfatin-1 levels in type 2 diabetes patients receiving antidiabetic treatment (MD = −0.26; 95% CI = −0.33 to −0.20. In conclusion, the analysis supports a relationship between circulating nesfatin-1 levels and type 2 diabetes, where newly diagnosed type 2 diabetes was associated with an elevated Nesfatin-1 level, and type 2 diabetes patients receiving antidiabetic treatment showed lower circulating nesfatin-1 levels.

  20. Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults.

    Science.gov (United States)

    Wang, Rui; Hong, Jie; Cao, Yanan; Shi, Juan; Gu, Weiqiong; Ning, Guang; Zhang, Yifei; Wang, Weiqing

    2015-03-01

    MicroRNAs (miRNAs) are involved in the regulation of adiposity, but functional studies have yielded inconclusive results. Examining the associations of circulating miRNAs levels with obesity and insulin sensitivity in humans may lead to improved insights. Serum samples collected from 112 obese and control subjects (50.0% men) were randomly divided and combined into four pools (28 samples in each obese or control pool). The genome-wide circulating miRNA profiles were detected via microarray. Elevated miR-122 was selected and validated in individual serum samples from 123 obese (46.7% men) and 107 control (50.0% men) young adults. Associations between circulating miR-122 levels and parameters related to adiposity, insulin resistance, lipid profiles and hepatic enzymes were further assessed. Thirty-four miRNAs were found to be expressed differently in the sera of obese patients compared with control subjects (Pobese patients had 3.07-fold higher circulating miR-122 levels than controls (Pobesity and insulin resistance in young adults. These findings provide a better understanding regarding the role of miRNAs in adiposity and insulin sensitivity. © 2015 European Society of Endocrinology.

  1. Correlates of Circulating 25-Hydroxyvitamin D

    OpenAIRE

    McCullough, Marjorie L.; Weinstein, Stephanie J.; Freedman, D. Michal; Helzlsouer, Kathy; Flanders, W. Dana; Koenig, Karen; Kolonel, Laurence; Laden, Francine; Le Marchand, Loic; Purdue, Mark; Snyder, Kirk; Stevens, Victoria L.; Stolzenberg-Solomon, Rachael; Virtamo, Jarmo; Yang, Gong

    2010-01-01

    Low vitamin D status is common globally and is associated with multiple disease outcomes. Understanding the correlates of vitamin D status will help guide clinical practice, research, and interpretation of studies. Correlates of circulating 25-hydroxyvitamin D (25(OH)D) concentrations measured in a single laboratory were examined in 4,723 cancer-free men and women from 10 cohorts participating in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers, which covers a worldwide geogra...

  2. Circulating fluidized bed boilers design and operations

    CERN Document Server

    Basu, Prabir

    1991-01-01

    This book provides practicing engineers and students with insight into the design and operation of circulating fluidized bed (CFB) boilers. Through a combination of theoretical concepts and practical experience, this book gives the reader a basic understanding of the many aspects of this subject.Important environmental considerations, including solid waste disposal and predicted emissions, are addressed individually in separate chapters. This book places an emphasis on combustion, hydrodynamics, heat transfer, and material issues, and illustrates these concepts with numerous examples of pres

  3. Music Circulation and Transmission in Tbilisi, Georgia

    OpenAIRE

    Sebald, Brigita

    2013-01-01

    This dissertation, based upon two years research in Tbilisi, Georgia, questions how popular music travels from the performer to the audience and how it circulates among audience members. After the disintegration of the Soviet Union in the early 1990s, the state-run music industry collapsed, taking the infrastructure for music distribution with it. In the years since, a music industry has not been rebuilt due to uncertain economic realities and a shaky political situation. Because of this, per...

  4. Periodontitis and increase in circulating oxidative stress

    OpenAIRE

    Takaaki Tomofuji; Koichiro Irie; Toshihiro Sanbe; Tetsuji Azuma; Daisuke Ekuni; Naofumi Tamaki; Tatsuo Yamamoto; Manabu Morita

    2009-01-01

    Reactive oxygen species (ROS) are products of normal cellular metabolism. However, excessive production of ROS oxidizes DNA, lipids and proteins, inducing tissue damage. Studies have shown that periodontitis induces excessive ROS production in periodontal tissue. When periodontitis develops, ROS produced in the periodontal lesion diffuse into the blood stream, resulting in the oxidation of blood molecules (circulating oxidative stress). Such oxidation may be detrimental to systemic health. Fo...

  5. Engineering Judgment and Natural Circulation Calculations

    OpenAIRE

    Ferreri, J. C.

    2011-01-01

    The analysis performed to establish the validity of computer code results in the particular field of natural circulation flow stability calculations is presented in the light of usual engineering practice. The effects of discretization and closure correlations are discussed and some hints to avoid undesired mistakes in the evaluations performed are given. Additionally, the results are presented for an experiment relevant to the way in which a (small) number of skilled, nuclear safety analysts...

  6. Nitric oxide : An ally in extracorporeal circulation?

    OpenAIRE

    Melki, Vilyam

    2016-01-01

    Many complications associated with heart surgery are due to the negative effects of extracorporeal circulation (ECC). Some of these complications may be attributed to ECC-induced activation of inflammation and coagulation pathways. The inflammatory reaction may be caused by the interaction of blood components with air and the artificial surfaces of the ECC, from substances produced due to ischaemia-reperfusion injury of the heart and lungs, and from increased release of endotoxin from ischemi...

  7. The creation and circulation of public geographies

    OpenAIRE

    Kitchin, Rob; Linehan, Denis; O'Callaghan, Cian; Lawton, Philip

    2013-01-01

    In response to the commentaries, we discuss further how social media disrupts and remakes the creation and circulation of geographical knowledges and potentially reconfigures the moral economy of the social sciences. In particular, we examine questions of what is meant by public geography, the publics which such geographies serve, alternative and complementary approaches to social media, the politics of authorship within collective blogs, the politics and mechanisms of knowledge c...

  8. NUCLA Circulating Atmospheric Fluidized Bed Demonstration Project

    Energy Technology Data Exchange (ETDEWEB)

    1992-02-01

    The objective of this DOE Cooperative Agreement is to conduct a cost-shared clean coal technology project to demonstrate the feasibility of circulating fluidized bed combustion technology and to evaluate economic, environmental, and operational benefits of CFB steam generators on a utility scale. At the conclusion of the Phase 2 program, testing related to satisfying these objectives was completed. Data analysis and reporting are scheduled for completion by October 1991. (VC)

  9. First circulating beam in the AA

    CERN Multimedia

    CERN PhotoLab

    1980-01-01

    On 3 July 1980, two years after project authorization, beam circulated for the first time in the AA. It was a 3.5 GeV/c proton test beam. We see an expecting crowd, minutes before the happy event. The persons are to numerous to name them all. Heribert Koziol, apparently asleep, is answering the call from an impatient director. See also 8007094.

  10. Circulating procoagulant microparticles in cancer patients

    OpenAIRE

    Thaler, Johannes; Ay, Cihan; Weinstabl, Harald; Dunkler, Daniela; Simanek, Ralph; Vormittag, Rainer; Freyssinet, Jean-Marie; Zielinski, Christoph; Pabinger, Ingrid

    2010-01-01

    Abstract Accumulating evidence indicates that microparticles (MPs) are important mediators of the interaction between cancer and the hemostatic system. We conducted a large prospective cohort study to determine whether the number of circulating procoagulant MPs is elevated in cancer patients and whether the elevated MP levels are predictive of occurrence of venous thrombembolism (VTE). We analyzed plasma samples of 728 cancer patients from the ongoing prospective observational Vien...

  11. Circulation in a Short Cylindrical Couette System

    Energy Technology Data Exchange (ETDEWEB)

    Akira Kageyama; Hantao Ji; Jeremy Goodman

    2003-07-08

    In preparation for an experimental study of magnetorotational instability (MRI) in liquid metal, we explore Couette flows having height comparable to the gap between cylinders, centrifugally stable rotation, and high Reynolds number. Experiments in water are compared with numerical simulations. The flow is very different from that of an ideal, infinitely long Couette system. Simulations show that endcaps co-rotating with the outer cylinder drive a strong poloidal circulation that redistributes angular momentum. Predicted toroidal flow profiles agree well with experimental measurements. Spin-down times scale with Reynolds number as expected for laminar Ekman circulation; extrapolation from two-dimensional simulations at Re less than or equal to 3200 agrees remarkably well with experiment at Re approximately equal to 106. This suggests that turbulence does not dominate the effective viscosity. Further detailed numerical studies reveal a strong radially inward flow near both endcaps. After turning vertically along the inner cylinder, these flows converge at the midplane and depart the boundary in a radial jet. To minimize this circulation in the MRI experiment, endcaps consisting of multiple, differentially rotating rings are proposed. Simulations predict that an adequate approximation to the ideal Couette profile can be obtained with a few rings.

  12. Circulation in a Short Cylindrical Couette System

    International Nuclear Information System (INIS)

    Akira Kageyama; Hantao Ji; Jeremy Goodman

    2003-01-01

    In preparation for an experimental study of magnetorotational instability (MRI) in liquid metal, we explore Couette flows having height comparable to the gap between cylinders, centrifugally stable rotation, and high Reynolds number. Experiments in water are compared with numerical simulations. The flow is very different from that of an ideal, infinitely long Couette system. Simulations show that endcaps co-rotating with the outer cylinder drive a strong poloidal circulation that redistributes angular momentum. Predicted toroidal flow profiles agree well with experimental measurements. Spin-down times scale with Reynolds number as expected for laminar Ekman circulation; extrapolation from two-dimensional simulations at Re less than or equal to 3200 agrees remarkably well with experiment at Re approximately equal to 106. This suggests that turbulence does not dominate the effective viscosity. Further detailed numerical studies reveal a strong radially inward flow near both endcaps. After turning vertically along the inner cylinder, these flows converge at the midplane and depart the boundary in a radial jet. To minimize this circulation in the MRI experiment, endcaps consisting of multiple, differentially rotating rings are proposed. Simulations predict that an adequate approximation to the ideal Couette profile can be obtained with a few rings

  13. When Prostate Cancer Circulates in the Bloodstream

    Directory of Open Access Journals (Sweden)

    Virginie Vlaeminck-Guillem

    2015-10-01

    Full Text Available Management of patients with prostate cancer is currently based on imperfect clinical, biological, radiological and pathological evaluation. Prostate cancer aggressiveness, including metastatic potential, remains difficult to accurately estimate. In an attempt to better adapt therapeutics to an individual (personalized medicine, reliable evaluation of the intrinsic molecular biology of the tumor is warranted, and particularly for all tumor sites (primary tumors and secondary sites at any time of the disease progression. As a consequence of their natural tendency to grow (passive invasion or as a consequence of an active blood vessel invasion by metastase-initiating cells, tumors shed various materials into the bloodstream. Major efforts have been recently made to develop powerful and accurate methods able to detect, quantify and/or analyze all these circulating tumor materials: circulating tumors cells, disseminating tumor cells, extracellular vesicles (including exosomes, nucleic acids, etc. The aim of this review is to summarize current knowledge about these circulating tumor materials and their applications in translational research.

  14. Diagnosis of boundary-layer circulations.

    Science.gov (United States)

    Beare, Robert J; Cullen, Michael J P

    2013-05-28

    Diagnoses of circulations in the vertical plane provide valuable insights into aspects of the dynamics of the climate system. Dynamical theories based on geostrophic balance have proved useful in deriving diagnostic equations for these circulations. For example, semi-geostrophic theory gives rise to the Sawyer-Eliassen equation (SEE) that predicts, among other things, circulations around mid-latitude fronts. A limitation of the SEE is the absence of a realistic boundary layer. However, the coupling provided by the boundary layer between the atmosphere and the surface is fundamental to the climate system. Here, we use a theory based on Ekman momentum balance to derive an SEE that includes a boundary layer (SEEBL). We consider a case study of a baroclinic low-level jet. The SEEBL solution shows significant benefits over Ekman pumping, including accommodating a boundary-layer depth that varies in space and structure, which accounts for buoyancy and momentum advection. The diagnosed low-level jet is stronger than that determined by Ekman balance. This is due to the inclusion of momentum advection. Momentum advection provides an additional mechanism for enhancement of the low-level jet that is distinct from inertial oscillations.

  15. The dynamics of the coronary collateral circulation.

    Science.gov (United States)

    Zimarino, Marco; D'Andreamatteo, Mariangela; Waksman, Ron; Epstein, Stephen E; De Caterina, Raffaele

    2014-04-01

    Coronary collaterals are present at birth, with wide interindividual variation in their functional capacity. These vessels protect jeopardized myocardium, and the number of collaterals and the extent of their coverage are associated with improved survival in patients with coronary heart disease. The collateral circulation is not a permanent set of structures, but undergoes dynamic changes with important consequences for cardioprotection. If a severe atherosclerotic lesion develops in an artery supplying tissue downstream of a total occlusion through collateral blood flow, pressure gradients across the collateral bed change. The result is that some of the collateral flow previously supplying the perfusion territory of the totally occluded artery is redirected to the perfusion territory of the donor artery, thus producing a 'collateral steal'. The collateral circulation can regress once antegrade flow in the main dependent artery is re-established, as occurs following the recanalization of a chronic total occlusion. The clinical benefits of coronary revascularization must be cautiously weighed against the risk of reducing the protective support derived from coronary collaterals. Consequently, pharmacological, gene-based, and cell-based therapeutic attempts have been made to enhance collateral function. Although such approaches have so far yielded no, or modest, beneficial results, the rapidly accruing data on coronary collateral circulation will hopefully lead to new effective therapeutic strategies.

  16. Circulation of a triaxial, charged ellipsoidal droplet

    International Nuclear Information System (INIS)

    Graber, J.L.; Rosensteel, G.

    2002-01-01

    The Kelvin circulation, which is the Casimir invariant of the general collective motion gcm(3) Lie algebra, is determined for a rapidly rotating triaxial nucleus in the classical domain. The potential energy is approximated by the sum of Coulomb repulsion and attractive surface energy terms, and the kinetic energy is adopted from the Riemann ellipsoidal model. An accurate approximation valid for both small and large deformations is reported for the potential energy. The Riemann ellipsoid theory allows for collective rotation in the continuum from rigid body motion to irrotational flow; the rigidity parametrizes this kinematical continuum. Analytic formulas are derived for the circulation, angular momentum, and energy as functions of the axis lengths, fissility, and rigidity. In particular, the bifurcation point to Jacobi triaxial shapes from noncollective oblate spheroids is given by a simple analytic formula. For a given fissility, the bifurcation point depends sensitive- ly on the rigidity. The Kelvin circulation remains approximately constant for triaxial ellipsoids as the angular momentum increases. This implies that gcm(3) is an approximate partial dynamical symmetry for rapidly rotating triaxial nuclei

  17. Formation of germline chimera Gaok chicken used circulation primordial germ cells (circulation PGCs fresh and thawed

    Directory of Open Access Journals (Sweden)

    Kostaman T

    2014-03-01

    Full Text Available Formation of germline chimeras by transfer of chicken primordial germ cells (PGCs is one of the effective techniques for preservation and regeneration of genetic resources in chickens. This study attempted to form germline chimeras of Gaok chicken buy purifying circulated PGCs of donor embryo before it is transferred to the recipient (White Leghorn chickens=WL and studied the ability of recipient embryo on survival in incubators, and hatchability. This study used 200 fertile eggs of Gaok and 90 fertile WL breed all of the eggs was incubated at 380C and 60% humidity in a portable incubator. PGCs-circulation of the blood collected Gaok embryos at stage 14-16 were taken from the dorsal aorta, and then purified by centrifugation method using nycodenz. PGCs-circulation results further purification frozen in liquid nitrogen before being transferred to the recipient embryo. The results showed that for the development of embryos transferred to the fresh circulation of PGCs-circulation as many as 25 cells can survive up to day 14, while one of the transferred of 50 and 100 cells into recipient embryos was hatched (10%. On the contrari recipient embryos that are transferred to the frozen PGCs-circulation the embryos development was shorter, and only survived until day 10th (treatment 25 cells, day 14th (treatment of 50 cells and day 17th (treatment of 100 cells. It is concluded that the amount of PGCs-circulation embryos transferred to the recipient is one factor that influence the success of the development germline chimeras.

  18. 19 CFR 207.63 - Circulation of draft questionnaires.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review. (b...

  19. Exact Inverse Matrices of Fermat and Mersenne Circulant Matrix

    Directory of Open Access Journals (Sweden)

    Yanpeng Zheng

    2015-01-01

    Full Text Available The well known circulant matrices are applied to solve networked systems. In this paper, circulant and left circulant matrices with the Fermat and Mersenne numbers are considered. The nonsingularity of these special matrices is discussed. Meanwhile, the exact determinants and inverse matrices of these special matrices are presented.

  20. Appraisal of circulation routine duties in academic libraries | Hassan ...

    African Journals Online (AJOL)

    ... of brown charging system, book reservation, keeping of reserved collection, circulation of reserved books, treatment of overdue, lost of books on loan and library statistics among other as duties perform in circulation department of libraries. Keywords: Library Service, Circulation Duties, Challenges, Academic Libraries ...

  1. A Novel Method to Predict Circulation Control Noise

    Science.gov (United States)

    2016-03-17

    and incompressibility of the flow are automatically satisfied (Sirovich, 1987). The difference be- tween these two methods stems from the...From top left to bottom right 1 kHz, 2 kHz, 4 kHz, 8 kHz, 12 kHz , and 16 kHz. blowing and lowest blowing (CJ.l = 0 and Cll = 0.004 , respectively...also shown that at low frequencies for the lower blowing conditions (Gil = 0, Gil = 0.004, and Cll = 0.017) the levels are quite similar. By using

  2. Architecture and performance of neural networks for efficient A/C control in buildings

    International Nuclear Information System (INIS)

    Mahmoud, Mohamed A.; Ben-Nakhi, Abdullatif E.

    2003-01-01

    The feasibility of using neural networks (NNs) for optimizing air conditioning (AC) setback scheduling in public buildings was investigated. The main focus is on optimizing the network architecture in order to achieve best performance. To save energy, the temperature inside public buildings is allowed to rise after business hours by setting back the thermostat. The objective is to predict the time of the end of thermostat setback (EoS) such that the design temperature inside the building is restored in time for the start of business hours. State of the art building simulation software, ESP-r, was used to generate a database that covered the years 1995-1999. The software was used to calculate the EoS for two office buildings using the climate records in Kuwait. The EoS data for 1995 and 1996 were used for training and testing the NNs. The robustness of the trained NN was tested by applying them to a 'production' data set (1997-1999), which the networks have never 'seen' before. For each of the six different NN architectures evaluated, parametric studies were performed to determine the network parameters that best predict the EoS. External hourly temperature readings were used as network inputs, and the thermostat end of setback (EoS) is the output. The NN predictions were improved by developing a neural control scheme (NC). This scheme is based on using the temperature readings as they become available. For each NN architecture considered, six NNs were designed and trained for this purpose. The performance of the NN analysis was evaluated using a statistical indicator (the coefficient of multiple determination) and by statistical analysis of the error patterns, including ANOVA (analysis of variance). The results show that the NC, when used with a properly designed NN, is a powerful instrument for optimizing AC setback scheduling based only on external temperature records

  3. Atlantic Meridional Overturning Circulation response to idealized external forcing

    Energy Technology Data Exchange (ETDEWEB)

    Park, W.; Latif, M. [Leibniz-Institut fuer Meereswissenschaften an der Universitaet Kiel, Kiel (Germany)

    2012-10-15

    The response of the Atlantic Meridional Overturning Circulation (AMOC) to idealized external (solar) forcing is studied in terms of the internal (unforced) AMOC modes with the Kiel Climate Model (KCM), a coupled atmosphere-ocean-sea ice general circulation model. The statistical investigation of KCM's internal AMOC variability obtained from a multi-millennial control run yields three distinct modes: a multi-decadal mode with a period of about 60 years, a quasi-centennial mode with a period of about 100 years and a multi-centennial mode with a period of about 300-400 years. Most variance is explained by the multi-centennial mode, and the least by the quasi-centennial mode. The solar constant varies sinusoidally with two different periods (100 and 60 years) in forced runs with KCM. The AMOC response to the external forcing is rather complex and nonlinear. It involves strong changes in the frequency structure of the variability. While the control run depicts multi-timescale behavior, the AMOC variability in the experiment with 100 year forcing period is channeled into a relatively narrow band centered near the forcing period. It is the quasi-centennial AMOC mode with a period of just under 100 years which is excited, although it is heavily damped in the control run. Thus, the quasi-centennial mode retains its period which does not correspond exactly to the forcing period. Surprisingly, the quasi-centennial mode is also most strongly excited when the forcing period is set to 60 years, the period of the multi-decadal mode which is rather prominent in the control run. It is largely the spatial structure of the forcing rather than its period that determines which of the three internal AMOC modes is excited. The results suggest that we need to understand the full modal structure of the internal AMOC variability in order to understand the circulation's response to external forcing. This could be a challenge for climate models: we cannot necessarily expect that the

  4. A Circulating Current Suppression Method for Parallel Connected Voltage-Source-Inverters (VSI) with Common DC and AC Buses

    DEFF Research Database (Denmark)

    Wei, Baoze; Guerrero, Josep M.; Quintero, Juan Carlos Vasquez

    2016-01-01

    This paper describes a theoretical with experiment study on a control strategy for the parallel operation of threephase voltage source inverters (VSI), to be applied to uninterruptible power systems (UPS). A circulating current suppression strategy for parallel VSIs is proposed in this paper based...... on circulating current control loops used to modify the reference currents by compensating the error currents among parallel inverters. Both of the cross and zero-sequence circulating currents are considered. The proposed method is coordinated together with droop and virtual impedance control. In this paper......, droop control is used to generate the reference voltage of each inverter, and the virtual impedance is used to fix the output impedance of the inverters. In addition, a secondary control is used in order to recover the voltage deviation caused by the virtual impedance. And the auxiliary current control...

  5. A multimodel comparison of centennial Atlantic meridional overturning circulation variability

    Energy Technology Data Exchange (ETDEWEB)

    Menary, Matthew B.; Vellinga, Michael; Palmer, Matthew D. [Met Office Hadley Centre, Exeter, Devon (United Kingdom); Park, Wonsun; Latif, Mojib [IFM-GEOMAR, Leibniz-Institut fuer Meereswissenschaften, Kiel (Germany); Lohmann, Katja; Jungclaus, Johann H. [Max Planck Inst Meteorol, Hamburg (Germany)

    2012-06-15

    A mechanism contributing to centennial variability of the Atlantic Meridional Overturning Circulation (AMOC) is tested with multi-millennial control simulations of several coupled general circulation models (CGCMs). These are a substantially extended integration of the 3rd Hadley Centre Coupled Climate Model (HadCM3), the Kiel Climate Model (KCM), and the Max Plank Institute Earth System Model (MPI-ESM). Significant AMOC variability on time scales of around 100 years is simulated in these models. The centennial mechanism links changes in the strength of the AMOC with oceanic salinities and surface temperatures, and atmospheric phenomena such as the Intertropical Convergence Zone (ITCZ). 2 of the 3 models reproduce all aspects of the mechanism, with the third (MPI-ESM) reproducing most of them. A comparison with a high resolution paleo-proxy for Sea Surface Temperatures (SSTs) north of Iceland over the last 4,000 years, also linked to the ITCZ, suggests that elements of this mechanism may also be detectable in the real world. (orig.)

  6. Framing Openness. The Digital Circulation of Israel's National Photographic Memory

    Directory of Open Access Journals (Sweden)

    Nathalie Casemajor

    2014-03-01

    Full Text Available Since 1948, the Government Press Office of Israel has been collecting and producing an extensive archive of photographs representing the birth and development of the Israeli nation state. Digitized and published online, this archive functions as a visual memorial of Israel, an example of what Jan Assman calls “bonding memory”, a form of memory that connects individuals to a political body, and which acts to frame a collective national identity. In 2011, the copyright terms of this archive were changed to encourage the circulation and reuse of images. This decision echoes a broader trend towards the “opening” of large data sets on the Web (“open data”, “open archives”, “open government”. At the same time, the ongoing Arab-Israeli conflict and the existence of contesting narratives of the creation of Israel threaten the integrity of the official national memory. In this context, what are the conditions and limits of “opening” the national photographic archive? Examining contemporary ideology of the “open” in new media discourses and the free culture movement, this paper investigates the conditions of circulation and appropriation of memory and the role of copyright as a potential tool to control freedom of expression.

  7. Implementation of Moderator Circulation Test Temperature Measurement System

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Yeong Muk; Hong, Seok Boong; Kim, Min Seok; Choi, Hwa Rim [KAERI, Daejeon (Korea, Republic of); Kim, Hyung Shin [Chungnam University, Daejeon (Korea, Republic of)

    2016-05-15

    Moderator Circulation Test(MCT) facility is 1/4 scale facility designed to reproduce the important characteristics of moderator circulation in a CANDU6 calandria under a range of operating conditions. MCT is an equipment with 380 acrylic pipes instead of the heater rods and a preliminary measurement of velocity field using PIV(Particle Image Velocimetry) is performed under the iso-thermal test conditions. The Korea Atomic Energy Research Institute (KAERI) started implementation of MCT Temperature Measurement System (TMS) using multiple infrared sensors. To control multiple infrared sensors, MCT TMS is implemented using National Instruments (NI) LabVIEW programming language. The MCT TMS is implemented to measure sensor data of multiple infrared sensors using the LabVIEW. The 35 sensor pipes of MCT TMS are divided into 2 ports to meet the minimum measurement time of 0.2 seconds. The software of MCT TMS is designed using collection function and processing function. The MCT TMS has the function of monitoring the states of multiple infrared sensors. The GUI screen of MCT TMS is composed of sensor pipe categories for user.

  8. Implementation of Moderator Circulation Test Temperature Measurement System

    International Nuclear Information System (INIS)

    Lim, Yeong Muk; Hong, Seok Boong; Kim, Min Seok; Choi, Hwa Rim; Kim, Hyung Shin

    2016-01-01

    Moderator Circulation Test(MCT) facility is 1/4 scale facility designed to reproduce the important characteristics of moderator circulation in a CANDU6 calandria under a range of operating conditions. MCT is an equipment with 380 acrylic pipes instead of the heater rods and a preliminary measurement of velocity field using PIV(Particle Image Velocimetry) is performed under the iso-thermal test conditions. The Korea Atomic Energy Research Institute (KAERI) started implementation of MCT Temperature Measurement System (TMS) using multiple infrared sensors. To control multiple infrared sensors, MCT TMS is implemented using National Instruments (NI) LabVIEW programming language. The MCT TMS is implemented to measure sensor data of multiple infrared sensors using the LabVIEW. The 35 sensor pipes of MCT TMS are divided into 2 ports to meet the minimum measurement time of 0.2 seconds. The software of MCT TMS is designed using collection function and processing function. The MCT TMS has the function of monitoring the states of multiple infrared sensors. The GUI screen of MCT TMS is composed of sensor pipe categories for user

  9. Role of atmospheric circulations in haze pollution in December 2016

    Science.gov (United States)

    Yin, Zhicong; Wang, Huijun

    2017-09-01

    In the east of China, recent haze pollution has been severe and damaging. In addition to anthropogenic emissions, atmospheric circulations and local meteorological conditions were conducive factors. The number of December haze days over North China and the Huanghuai area has increased sharply since 2010 and was greatest in 2016. During 2016, the most aggressive control measures for anthropogenic emissions were implemented from 16 to 21 December, but the most severe haze pollution still occurred, covering approximately 25 % of the land area of China and lasting for 6 days. The atmospheric circulations must play critical roles in the sub-seasonal haze events. Actually, the positive phase of the East Atlantic-West Russia pattern in the middle troposphere strengthened the anomalous anti-cyclone over the NH area that confined vertical motion below. The associated southerly anomalies made the cold air and surface wind speed weaker, but enhanced the humid flow. Thus, the horizontal and vertical dispersion of atmospheric particulates was suppressed and the pollutants gathered within a narrow space. In December 2016, these key indices were strongly beneficial for haze occurrence and combined to result in the severest haze pollution. The influences of the preceding autumn sea surface temperature near the Gulf of Alaska and the subtropical eastern Pacific, October-November snow cover in western Siberia, and associated physical processes on haze pollution are also discussed.

  10. The stability of the thermohaline circulation in a coupled ocean-atmosphere general circulation model

    Energy Technology Data Exchange (ETDEWEB)

    Schiller, A. [Max-Planck-Institut fuer Meteorologie, Hamburg (Germany); Mikolajewicz, U. [Max-Planck-Institut fuer Meteorologie, Hamburg (Germany); Voss, R. [Deutsches Klimarechenzentrum (DKRZ), Hamburg (Germany)

    1996-02-01

    The stability of the Atlantic thermohaline circulation against meltwater input is investigated in a coupled ocean-atmosphere general circulation model. The meltwater input to the Labrador Sea is increased linearly for 250 years to a maximum input of 0.625 Sv and then reduced again to 0 (both instantaneously and slowly decreasing over 250 years). The resulting freshening forces a shutdown of the formation of North Atlantic deepwater and a subsequent reversal of the thermohaline circulation of the Atlantic, filling the deep Atlantic with Antarctic bottom water. The change in the overturning pattern causes a drastic reduction of the Atlantic northward heat transport, resulting in a strong cooling with maximum amplitude over the northern North Atlantic and a southward shift of the sea-ice margin in the Atlantic. Due to the increased meridional temperature gradient, the Atlantic intertropical convergence zone is displaced southward and the westerlies in the northern hemisphere gain strength. We identify four main feedbacks affecting the stability of the thermohaline circulation: the change in the overturning circulation of the Atlantic leads to longer residence times of the surface waters in high northern latitudes, which allows them to accumulate more precipitation and runoff from the continents, which results in an increased stability in the North Atlantic.

  11. Elimination of zero sequence circulating current between parallel operating three-level inverters

    DEFF Research Database (Denmark)

    Li, Kai; Wang, Xiaodong; Dong, Zhenhua

    2016-01-01

    In order to suppress the zero sequence circulating currents (ZSCCs) between parallel operating three level voltage source inverters with common AC and DC buses, a common mode voltage reduction PWM (CMVR-PWM) technique and neural point potentials (NPPs) control based method is proposed in this paper...

  12. Circulating immune complexes, immunoglobulin classes (IgG, IgA ...

    African Journals Online (AJOL)

    Objective:- To evaluate serum levels of circulating immune complexes (CICs), immunoglobulin classes (IgG, IgA and IgM) and Complement Components (C3c, C4 and Factor B) in Nigerians with Type 1 or Type 2 diabetes mellitus. Design:- Case control study. Setting:- University College Hospital, Ibadan, Oyo State, Nigeria.

  13. An Integrated Systems Approach: A Description of an Automated Circulation Management System.

    Science.gov (United States)

    Seifert, Jan E.; And Others

    These bidding specifications describe requirements for a turn-key automated circulation system for the University of Oklahoma Libraries. An integrated systems approach is planned, and requirements are presented for various subsystems: acquisitions, fund accounting, reserve room, and bibliographic and serials control. Also outlined are hardware…

  14. Conventional heat distribution systems and their control for room cooling; Konventionelle Waermeabgabesysteme und deren Regulierung fuer die Raumkuehlung - Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Schnyder, J. [Schnyder-Energie, Energie-Dienstleistungen, Bronschhofen (Switzerland); Feger, D.; Graf, J.; Rusterholtz, R. [Interstaatliche Hochschule fuer Technik Buchs NTB, Buchs (Switzerland); Schoeringhumer, D.; Cenci, D. [Arbonia AG, Arbon (Switzerland); Heule, D. [hps energieconsulting ag, Ingenieurbuero fuer nachhaltige Energie- und Gebaeudetechnik, Kuesnacht (Switzerland)

    2009-12-15

    This final report for the Swiss Federal Office of Energy (SFOE) examines how conventional heat distribution systems such as radiators and floor heating systems can be used for room cooling and the appropriate control requirements. Thermostatic valves used 'in reverse', their functional testing and the results obtained are discussed. Possibilities for their optimisation are examined. The apparatus used for the measurements made on both radiator and floor-heating systems is reported on and the results obtained are presented and discussed. Further, simulations used are looked at and examples of the results obtained for rooms with varying glazed surfaces are presented and discussed.

  15. Explicit Determinants of the RFPrLrR Circulant and RLPrFrL Circulant Matrices Involving Some Famous Numbers

    Directory of Open Access Journals (Sweden)

    Tingting Xu

    2014-01-01

    Full Text Available Circulant matrices may play a crucial role in solving various differential equations. In this paper, the techniques used herein are based on the inverse factorization of polynomial. We give the explicit determinants of the RFPrLrR circulant matrices and RLPrFrL circulant matrices involving Fibonacci, Lucas, Pell, and Pell-Lucas number, respectively.

  16. Association of Circulating Orexin-A Level With Metabolic Risk Factors in North Indian Pre Menopausal Women.

    Science.gov (United States)

    Gupta, Vani; Mishra, Sameeksha; Kumar, Sandeep; Mishra, Supriya

    2015-01-01

    The present study was designed to investigate the association between circulating Orexin-A level with metabolic risk factors in North Indian adult women. 342 women were enrolled for the case-control study, 172 women were with metabolic syndrome (mets) and 170 healthy control women were without metabolic syndrome, (womets) according to (NCEP ATP III criteria). Circulating Orexin-A level was determined by enzyme-linked immunosorbent assay. Observations indicated low levels of orexin-A (26.06 ± 6.09 ng/ml) in women with mets and other metabolic risk factors compared to women without metabolic syndrome (36.50 ± 10.42 ng/ml). Further, in women with metabolic syndrome, circulating Orexin A was significantly associated with waist circumference, triglyceride (negative correlation) and hyperdensity lipoprotein (positive correlation). Our study shows that circulating Orexin A was found to be significantly associated with hyperlipidemia, obesity and obesity-related disorders in North Indian premenopausal women.

  17. Development of Temperature Control Solutions for Non-Instrumented Nucleic Acid Amplification Tests (NINAAT

    Directory of Open Access Journals (Sweden)

    Tamás Pardy

    2017-06-01

    Full Text Available Non-instrumented nucleic acid amplification tests (NINAAT are a novel paradigm in portable molecular diagnostics. They offer the high detection accuracy characteristic of nucleic acid amplification tests (NAAT in a self-contained device, without the need for any external instrumentation. These Point-of-Care tests typically employ a Lab-on-a-Chip for liquid handling functionality, and perform isothermal nucleic acid amplification protocols that require low power but high accuracy temperature control in a single well-defined temperature range. We propose temperature control solutions based on commercially available heating elements capable of meeting these challenges, as well as demonstrate the process by which such elements can be fitted to a NINAAT system. Self-regulated and thermostat-controlled resistive heating elements were evaluated through experimental characterization as well as thermal analysis using the finite element method (FEM. We demonstrate that the proposed solutions can support various NAAT protocols, as well as demonstrate an optimal solution for the loop-mediated isothermal amplification (LAMP protocol. Furthermore, we present an Arduino-compatible open-source thermostat developed for NINAAT applications.

  18. Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis

    Science.gov (United States)

    Zhao, Xiaoyan; Okeke, Nwora Lance; Sharpe, Orr; Batliwalla, Franak M; Lee, Annette T; Ho, Peggy P; Tomooka, Beren H; Gregersen, Peter K; Robinson, William H

    2008-01-01

    Introduction There is increasing evidence that autoantibodies and immune complexes (ICs) contribute to synovitis in rheumatoid arthritis (RA), yet the autoantigens incorporated in ICs in RA remain incompletely characterised. Methods We used the C1q protein to capture ICs from plasma derived from human RA and control patients. Antibodies specific for immunoglobulin were used to detect ICs, and fibrinogen antibodies were used to detect fibrinogen-containing ICs. RA and control plasma were separated by liquid chromatography, and fractions then characterised by ELISA, immunoblotting and mass spectrometry. Immunohistochemical staining was performed on rheumatoid synovial tissue. Results C1q-immunoassays demonstrated increased levels of IgG (p = 0.01) and IgM (p = 0.0002) ICs in plasma derived from RA patients possessing anti-cyclic citrullinated peptide (CCP+) autoantibodies as compared with healthy controls. About one-half of the anti-CCP+ RA possessed circulating ICs containing fibrinogen (p = 0.0004). Fractionation of whole RA plasma revealed citrullinated fibrinogen in the high molecular weight fractions that contained ICs. Positive correlations were observed between fibrinogen-containing ICs and anti-citrullinated fibrinogen autoantibodies, anti-CCP antibody, rheumatoid factor and certain clinical characteristics. Immunohistochemical staining demonstrated co-localisation of fibrinogen, immunoglobulin and complement component C3 in RA pannus tissue. Mass spectrometry analysis of immune complexes immunoprecipitated from RA pannus tissue lysates demonstrated the presence of citrullinated fibrinogen. Conclusion Circulating ICs containing citrullinated fibrinogen are present in one-half of anti-CCP+ RA patients, and these ICs co-localise with C3 in the rheumatoid synovium suggesting that they contribute to synovitis in a subset of RA patients. PMID:18710572

  19. Application of noise analysis to stability determination of a natural circulation cooled BWR

    Energy Technology Data Exchange (ETDEWEB)

    Hagen, T.H.J.J. van der; Dam, H. van; Hoogenboom, J.E.; Nissen, W.H.M.; Oosterkamp, W.J.

    1988-01-01

    Experiments were performed on the Dodewaard natural circulation cooled BWR at different conditions. The absolute stability was determined by measuring system responses to control rod and steam flow valve steps. Changes in core stability were studied using the signal of an average power range monitor (APRM) in time domain (auto-correlation function and impulse response) and in frequency domain (power spectral density and peaking factor), the outlet void fraction and variations of the incore coolant velocity. It is shown that the reactor is very stable and that cooling by natural circulation improves load following. Stability monitoring can be performed by all mentioned methods but using APRM signals in frequency domain is preferred.

  20. All-in-one detector of circulating mRNA based on a smartphone

    Science.gov (United States)

    Cmiel, Vratislav; Gumulec, Jaromir; Svoboda, Ondrej; Raudenska, Martina; Hudcova, Kristyna; Sekora, Jiri; Balogh, Jaroslav; Masarik, Michal; Provaznik, Ivo

    2016-03-01

    Metallothionein is significantly elevated in various tumors, notably in prostate cancer on both mRNA and protein level. We demonstrated a strong predictive potential of free circulating metallothionein 2A isoform mRNA for patients with this cancer. Circulating mRNA detection relies on expensive equipment and requires high level of expertise. In this work we developed compact "all-in-one" laboratory system which replace microvolume spectrophotometer, thermocycler and realtime PCR machines. We managed to design and construct a microprocessor controlled heating/cooling chamber that ensures required temperature gradient. The chamber includes implemented optical system to enable fluorescence excitation and fluorescence analysis using a smart-phone.