WorldWideScience

Sample records for therapy equipment based

  1. How to Design and Equip a Mentalization-Based Play Therapy Room.

    Science.gov (United States)

    Rüth, Ulrich; Holch, Astrid

    2018-01-01

    Designing and equipping a play therapy room as a differentiated tool in a psychodynamic approach to child psychotherapy is seldom discussed. This article sketches out the equipment and furnishing of a play therapy room to be used for mentalization-based psychodynamic psychotherapy and gives examples of the use of such a room in practice.

  2. Radiation therapy sources, equipment and installations

    International Nuclear Information System (INIS)

    2011-03-01

    The safety code for Telegamma Therapy Equipment and Installations, (AERB/SC/MED-1) and safety code for Brachytherapy Sources, Equipment and Installations, (AERB/SC/MED-3) were issued by AERB in 1986 and 1988 respectively. These codes specified mandatory requirements for radiation therapy facilities, covering the entire spectrum of operations ranging from the setting up of a facility to its ultimate decommissioning, including procedures to be followed during emergency situations. The codes also stipulated requirements of personnel and their responsibilities. With the advent of new techniques and equipment such as 3D-conformal radiation therapy, intensity modulated radiation therapy, image guided radiation therapy, treatment planning system, stereotactic radiosurgery, stereotactic radiotherapy, portal imaging, integrated brachytherapy and endovascular brachytherapy during the last two decades, AERB desires that these codes be revised and merged into a single code titled Radiation Therapy Sources, Equipment, and Installations

  3. Diagnostic imaging and radiation therapy equipment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-05-01

    This is the third edition of CSA Standard C22.2 No. 114 (now CAN/CSA-C22.2 No. 114), which is one of a series of standards issued by the Canadian Standards Association under Part II of the Canadian Electrical Code. This edition marks an important shift towards harmonization of Canadian requirements with those of the European community and the United States. Also important to this edition is the expansion of its scope to include the complete range of diagnostic imaging and radiation therapy equipment, rather than solely radiation-emitting equipment. In so doing, equipment previously addressed by CSA Standard C22.2 No. 125, Electromedical Equipment, specifically lasers for medical applications and diagnostic ultrasound units, is now dealt with in the new edition. By virtue of this expanded scope, many of the technical requirements in the electromedical equipment standard have been introduced to the new edition, thereby bringing CSA Standard C22.2 No. 114 up to date. 14 tabs., 16 figs.

  4. Diagnostic imaging and radiation therapy equipment

    International Nuclear Information System (INIS)

    1990-05-01

    This is the third edition of CSA Standard C22.2 No. 114 (now CAN/CSA-C22.2 No. 114), which is one of a series of standards issued by the Canadian Standards Association under Part II of the Canadian Electrical Code. This edition marks an important shift towards harmonization of Canadian requirements with those of the European community and the United States. Also important to this edition is the expansion of its scope to include the complete range of diagnostic imaging and radiation therapy equipment, rather than solely radiation-emitting equipment. In so doing, equipment previously addressed by CSA Standard C22.2 No. 125, Electromedical Equipment, specifically lasers for medical applications and diagnostic ultrasound units, is now dealt with in the new edition. By virtue of this expanded scope, many of the technical requirements in the electromedical equipment standard have been introduced to the new edition, thereby bringing CSA Standard C22.2 No. 114 up to date. 14 tabs., 16 figs

  5. Radiation therapy in Africa: distribution and equipment

    International Nuclear Information System (INIS)

    Levin, C.V.; Meghzifene, A.; Gueddari, B. el

    1999-01-01

    Africa is the least developed continent as regards radiation oncology resources. The documented ASR of cancer is of the order of 1 to 2 per 1000. With improving health care this is becoming more significant. This review was undertaken to help develop priorities for the region. Radiation Oncology departments in Africa were identified and a survey of their equipment performed. These were compared to the reported situation in 1991. Population tables for the year 2000 were compared to available megavoltage machines. Of 56 countries in Africa, only 22 are confidently known to have megavoltage therapy concentrated in the southern and northern extremes of the continent. The 155 megavoltage machines operating represents over 100% increase over the past 8 years. The population served by each megavoltage machine ranges from 0.6 million to 70 million per machine. Overall, only 50% of the population have some access to Radiation Oncology services. Progress has been made in initiating radiation oncology in Ghana, Ethiopia and Namibia. There has been some increase in machines in Algeria, Egypt, Libya, Morocco and Tunisia. However, a large backlog exists for basic radiation services. (author.)

  6. Equipment for light therapy BIOFIE family

    International Nuclear Information System (INIS)

    Corcho Corcho, C. A.; Perez Garcia, A.; Herrera Rodriguez, R.

    2016-01-01

    The development experienced in the design and implementation of equipment are presented, within the subject matter of the application of low level laser and also them LED of high efficiency with therapeutic purposes in health and also in animal health, besides, the use of this technology for this application in agriculture. All the equipment that show up has been developed for the Dpto. of Bioengineer of High Politechnical Institute Jose A. Echeverria (CUJAE) in association with Dpto. of Prototypes of the same institution, under the trademark BIOFIE. Like fundamental and innovative characteristic we can make a comment that all equipment destined to health and animal health, work on continuos and modulated signal mode, using in this mode different bio frequencies. (Author)

  7. Equipment Qualification Data Base user manual

    International Nuclear Information System (INIS)

    Decker, Q.R.; Fackrell, L.J.; Fitch, L.R.; Meeky, O.B.

    1985-09-01

    This manual details the Equipment Qualification Data Base (EQDB), its usage, and contents. The EQDB consists of two files; the Plant Qualification File (PQF) and the Equipment Qualification File (EQF). The PQF contains plant specific environmental data and the EQF contains summaries of various test results. Two data management systems are used to manipulate the data and are discussed in this manual. SAS Institute System 2000 (S2K) is the management system for the PQF and Query Update (QU) is the operating system for the EQF. Each management system contains report writers. These writers and how to use them are discussed in detail in this manual

  8. Methodology for assessing laser-based equipment

    Science.gov (United States)

    Pelegrina-Bonilla, Gabriel; Hermsdorf, Jörg; Thombansen, Ulrich; Abels, Peter; Kaierle, Stefan; Neumann, Jörg

    2017-10-01

    Methodologies for the assessment of technology's maturity are widely used in industry and research. Probably the best known are technology readiness levels (TRLs), initially pioneered by the National Aeronautics and Space Administration (NASA). At the beginning, only descriptively defined TRLs existed, but over time, automated assessment techniques in the form of questionnaires emerged in order to determine TRLs. Originally TRLs targeted equipment for space applications, but the demands on industrial relevant equipment are partly different in terms of, for example, overall costs, product quantities, or the presence of competitors. Therefore, we present a commonly valid assessment methodology with the aim of assessing laser-based equipment for industrial use, in general. The assessment is carried out with the help of a questionnaire, which allows for a user-friendly and easy accessible way to monitor the progress from the lab-proven state to the application-ready product throughout the complete development period. The assessment result is presented in a multidimensional metric in order to reveal the current specific strengths and weaknesses of the equipment development process, which can be used to direct the remaining development process of the equipment in the right direction.

  9. Design and construction of stepper motor controller for brachy-therapy equipment

    International Nuclear Information System (INIS)

    Ahmad Rifai; Usep Setia Gunawan; Indarzah Masbatin Putra

    2011-01-01

    Based on a microcontroller, a stepper motor controller for brachy-therapy equipment has been designed and prototyped. The embedded control program routine and its other associated routines enable the microcontroller to generate required pulses via external commands for stepper motor based position control. The controller receives ASCII text command via a serial port. The constructed algorithm implements the widely used method that allows motor to rotate in three phases, i.e: acceleration, constant speed, and deceleration. (author)

  10. Safety management of software-based equipment

    CERN Document Server

    Boulanger, Jean-Louis

    2013-01-01

    A review of the principles of the safety of software-based equipment, this book begins by presenting the definition principles of safety objectives. It then moves on to show how it is possible to define a safety architecture (including redundancy, diversification, error-detection techniques) on the basis of safety objectives and how to identify objectives related to software programs. From software objectives, the authors present the different safety techniques (fault detection, redundancy and quality control). "Certifiable system" aspects are taken into account throughout the book. C

  11. Radiation hardened equipment and material data base

    International Nuclear Information System (INIS)

    Sumita, Kenji; Yamaoka, Hitoshi; Kakuta, Tsunemi; Shono, Yoshihiko; Nakamura, Tetsuo; Nakase, Yoshiaki; Furuta, Junichiro.

    1988-01-01

    In order to collect and put in order the results regarding radiation-withstanding equipment and materials, the Osaka Nuclear Science Association organized the committee composed of the experts in various fields in fiscal year 1986 for the purpose of building up the data base, and began the activity. From the trend of the research and development and the usefulness for the future, the fields of collecting data were decided as organic materials, optical fibers, semiconductor elements and compound semiconductors. By fiscal year 1987, the building-up of the prototype data base was aimed at, and system configuration, the making of the formats on the items and attributes of collected data, the action test of the system and so on were carried out. Under the background of the upgrading of LWRs, the development of FBRs and nuclear fusion reactors, the construction of a reprocessing plant and a low level waste storage facility, and the progress of various advanced technologies, the research on the equipment and materials having excellent radiation resistance and the development for heightening the performance have been carried out in many places separately, accordingly the activity for building up the prototype data base was begun, and about 600 cases were collected. (Kako, I.)

  12. Case Based Asset Maintenance for the Electric Equipment

    International Nuclear Information System (INIS)

    Kim, Ji-Hyeon; Jung, Jae-Cheon; Chang, Young-Woo; Chang, Hoon-Seon; Kim, Jae-Cheol; Kim, Hang-Bae; Kim, Kyu-Ho; Hur, Yong; Lee, Dong-Chul

    2006-01-01

    The electric equipment maintenance strategies are changing from PM(Preventive Maintenance) or CM(Corrective Maintenance) to CBM(Condition Based Maintenance). The main benefits of CBM are reduced possibility of service failures of critical equipment and reduced costs or maintenance work. In CBM, the equipment status need to be monitored continuously and a decision should be made whether an equipment need to be repaired or replaced. For the maintenance decision making, the CBR(Case Base Reasoning) system is introduced. The CBR system receives the current equipment status and retrieves the case based historic database to determine any possible equipment failure under current conditions. In retrieving the case based historic data, the suggested DSS(Decision Support System) uses a reasoning engine with an equipment/asset ontology that describes the equipment subsumption relationships

  13. Laser-based measuring equipment controlled by microcomputer

    International Nuclear Information System (INIS)

    Miron, N.; Sporea, D.; Velculescu, V.G.; Petre, M.

    1988-03-01

    Some laser-based measuring equipment controlled by microcomputer developed for industrial and scientific purposes are described. These equipments are intended for dial indicators verification, graduated rules measurement, and for very accurate measurement of the gravitational constant. (authors)

  14. [Equipment design for magnetic therapy and "Polus" devices].

    Science.gov (United States)

    Viktorov, V A; Malkov, Iu V

    1994-01-01

    Low-frequency magnetotherapy is among the most original therapeutical techniques since it is effective in treating most diseases and has practically no contraindications. Due to atraumaticity of a low-frequency electromagnetic field, the application of magnetotherapy is indicated in geriatric care, in particular. The VNIIMP-VITA Joint-Stock Company has developed a family of the Polyus system equipment for magnetotherapy, whereby all the well-known therapeutical procedures of low-frequency magnetotherapy can be performed. The magnetotherapeutic room equipped with Polyus-2D, Polyus-3, and Polyus-4 ensures a complete set of magneto-therapeutical exposure. The rooms are supplied by the VNIIMP-VITA Joint-Stock Company.

  15. The proton therapy system for MGH's NPTC: equipment description and progress report

    International Nuclear Information System (INIS)

    Jongen, Y.; Beeckman, W.; Cohilis, P.

    1996-01-01

    At the beginning of 1994, the Massachusetts General Hospital (MGH) of the Harvard Medical School in Boston (MA, USA) a pioneer in proton therapy since 1959, selected a team led by Ion Beam Applications SA (IBA) to supply the proton therapy equipment of its new Northeast Proton Therapy Centre (NPTC),. The IBA integrated system includes a compact 235 MeV isochronous cyclotron, a short energy selection transforming the fixed energy beam extracted form the cyclotron into a variable energy beam, one or more isocentric gantries fitted with a nozzle, a system consisting of one or more horizontal beam lines, a global control system including an accelerator control unit and several independent but networked therapy control stations, a global safety management system, and a robotic patient positioning system. The present paper presents the equipment being built for the NPTC. (author)

  16. Equipment response spectra for base-isolated shear beam structures

    International Nuclear Information System (INIS)

    Ahmadi, G.; Su, L.

    1992-01-01

    Equipment response spectra in base-isolated structure under seismic ground excitations are studied. The equipment is treated as a single-degree-of-freedom system attached to a nonuniform elastic beam structural model. Several leading base isolation systems, including the laminated rubber bearing, the resilient-friction base isolator with and without a sliding upper plate, and the EDF system are considered. Deflection and acceleration response spectra for the equipment and the shear beam structure subject to a sinusoidal and the accelerogram of the N00W component of El Centro 1940 earthquake are evaluated. Primary-secondary interaction effects are included in the analysis. Several numerical parametric studies are carried out and the effectiveness of different base isolation systems in protecting the nonstructural components is studied. It is shown that use of properly designed base isolation systems provides considerable protection for secondary systems, as well as, the structure against severe seismic loadings. (orig.)

  17. Application of risk-based inspection methods for cryogenic equipment

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    Risk-based Inspection (RBI) is widely applied across the world as part of Pressure Equipment Integrity Management, especially in the oil and gas industry, to generally reduce costs compared with time-based approaches and assist in assigning resources to the most critical equipment. One of the challenges in RBI is to apply it for low temperature and cryogenic applications, as there are usually no degradation mechanisms by which to determine a suitable probability of failure in the overall risk assessment. However, the assumptions used for other degradation mechanisms can be adopted to determine, qualitatively and semi-quantitatively, a consequence of failure within the risk assessment. This can assist in providing a consistent basis for the assumptions used in ensuring adequate process safety barriers and determining suitable sizing of relief devices. This presentation will discuss risk-based inspection in the context of cryogenic safety, as well as present some of the considerations for the risk assessme...

  18. Cell-Based Therapy

    Directory of Open Access Journals (Sweden)

    Masaaki Kitada

    2012-01-01

    Full Text Available Cell transplantation is a strategy with great potential for the treatment of Parkinson's disease, and many types of stem cells, including neural stem cells and embryonic stem cells, are considered candidates for transplantation therapy. Mesenchymal stem cells are a great therapeutic cell source because they are easy accessible and can be expanded from patients or donor mesenchymal tissues without posing serious ethical and technical problems. They have trophic effects for protecting damaged tissues as well as differentiation ability to generate a broad spectrum of cells, including dopamine neurons, which contribute to the replenishment of lost cells in Parkinson's disease. This paper focuses mainly on the potential of mesenchymal stem cells as a therapeutic cell source and discusses their potential clinical application in Parkinson's disease.

  19. [Diuretic-based therapy].

    Science.gov (United States)

    Presne, Claire; Monge, Matthieu; Mansour, Janette; Oprisiu, Roxana; Choukroun, Gabriel; Achard, Jean Michel; Fournier, Albert

    2007-10-01

    Diuretics are pharmacological agents that increase natriuresis through inhibition of tubular re-absorption of sodium. The mechanisms and site of this inhibition differ with each drug class, accounting for their additive effects on natriuresis increase and their hydroelectrolytic side effects. The response to a given diuretic dose depends on the diuretic concentration on the urine at its action site. This concentration may be decreased by pharmacokinetic factors such as encountered in renal insufficiency or in nephrotic syndrome. These resistance mechanisms of diuretics may be corrected by dose increase, previous diuretic fixation on albumin or warfarin administration. Once these mechanisms are opposed, the diuretic concentration for maximal efficacy is reached at is action site and the natriuresis obtained as the normal maximal plateau. This is not the case when an oedematous systemic disease with effective hypovolemia is present, like in heart failure or cirrhosis, or when chronic use of loop diuretics has induced a hypertrophy of the more distant part of the tubule. In theses cases, a pharmacodynamic resistance exists, resulting in a lower maximal natriuresis plateau in spite of adequate concentration of the diuretic at its action site, even in the absence of pharmacokinetic resistance factors. The main indications of diuretics are systemic oedematous disease and hypertension. In the oedematous diseases, diuretics indication is both straightforward and sufficient only if effective hypervolemia is present. The therapeutic approach is discussed according to the various clinical conditions and pathophysiological background. In uncomplicated hypertension, diuretics are the cornerstone of the therapy. The most suitable diuretic treatment for hypertension is an association of low doses thiazide (12.5-50 mg/day) with potassium sparing diuretics. Rare indications of diuretics are also reviewed.

  20. Regulations No. 59 of 20 February 1978 on X-ray skin therapy equipment up to 50 kV

    International Nuclear Information System (INIS)

    1978-01-01

    These regulations lay down the provisions to be complied with for the protection of medical staff and patients when using X-ray equipment for skin therapy. The operators of such equipment must comply with the technical guidelines contained in the regulations and provision is made for annual inspections to ensure that the devices meet the necessary safety standards. (NEA) [fr

  1. Quality and safety based management of radiological and clinical equipment

    International Nuclear Information System (INIS)

    Arora, S.; Saini, P.S.

    2001-01-01

    TQM (Total quality management) is the 'buzz' acronym expected in almost every aspect of industrial manufacturing, product development and services solicited by the outside agencies. The correct management of the many technological resources in health institutions in terms of efficiency, effectiveness and safety is a necessity in view of the criteria on which modern medicine is based. Almost all activities -be they diagnostic, therapeutic and rehabilitative - carried out within a modern hospital are based on widespread application of equipment and technology, the efficiency of which can directly influence the quality of service offered to the patient

  2. Data base EQDB - data base of the qualified equipment's for NPP

    International Nuclear Information System (INIS)

    Rovny, K.

    2009-01-01

    In the contribution, there is presented the project of the data base for qualified equipment's for nuclear power plants. The data base is operated by the 'Certification body which certified the products - the chosen equipment's for nuclear power plants', reg. No. P-028, at VUJE, Inc. Trnava. Data base will serve to the designers, the operators of the nuclear power plants and the workers from Nuclear regulatory authority of the Slovak Republic as a source of information about the state of concrete type equipment's qualification. In the first part of the contribution, there is information about the legislation and technical requirements for equipment's qualification, the way of demonstration and importance of the qualification for the operator. In the next part, there is presented the own structure of data base and the works with own data base regarding the examples of concrete equipment's. The data base will be accessible after the free registration on address WWW.EQDB.sk from 1.5.2009

  3. Design of EPON far-end equipment based on FTTH

    Science.gov (United States)

    Feng, Xiancheng; Yun, Xiang

    2008-12-01

    Now, most favors fiber access is mainly the EPON fiber access system. Inheriting from the low cost of Ethernet, usability and bandwidth of optical network, EPON technology is one of the best technologies in fiber access and is adopted by the carriers all over the world widely. According to the scheme analysis to FTTH fan-end equipment, hardware design of ONU is proposed in this paper. The FTTH far-end equipment software design deference modulation design concept, it divides the software designment into 5 function modules: the module of low-layer driver, the module of system management, the module of master/slave communication, and the module of main/Standby switch and the module of command line. The software flow of the host computer is also analyzed. Finally, test is made for Ethernet service performance of FTTH far-end equipment, E1 service performance and the optical path protection switching, and so on. The results of test indicates that all the items are accordance with technical request of far-end ONU equipment and possess good quality and fully reach the requirement of telecommunication level equipment. The far-end equipment of FTTH divides into several parts based on the function: the control module, the exchange module, the UNI interface module, the ONU module, the EPON interface module, the network management debugging module, the voice processing module, the circuit simulation module, the CATV module. In the downstream direction, under the protect condition, we design 2 optical modules. The system can set one group optical module working and another group optical module closure when it is initialized. When the optical fiber line is cut off, the LOS warning comes out. It will cause MUX to replace another group optical module, simultaneously will reset module 3701/3711 and will make it again test the distance, and will give the plug board MPC850 report through the GPIO port. During normal mode, the downstream optical signal is transformed into the

  4. Design principles and clinical possibilities with a new generation of radiation therapy equipment

    Energy Technology Data Exchange (ETDEWEB)

    Ruden, B P [Department of Hospital physics Karolinska institute, (Sudan)

    1997-12-31

    The main steps in the development of isocentric megavoltage external beam radiation therapy machines are briefly reviewed identifying three principal types or generations of equipment to date. The new fourth generation of equipment presented here is characterized by considerably increased flexibility in dose delivery through the use of scanned elementary electron and photon beams of very high quality. Furthermore, the wide energy range and the possibility of using high resolution multi leaf collimation with all beam modalities makes it possible to simplify irradiation techniques and increase the accuracy in dose delivery. The main design features are described including a dual magnet scanning system, a photon beam purging magnet, a helium atmosphere in the treatment head, a beam`s eye view video read-out system of the collimator setting and a radiotherapeutic computed tomography facility. Some of the clinical applications of this new type of radiation therapy machine are finally reviewed, such as the ease of performance, became flattening, beam filtering and compensation, and the simplification of many treatment techniques using the wide spectrum of high quality electron and photon beams. Finally, the interesting possibility of doing conformation and more general isocentric treatments with non-uniform beams using the multi leaf collimator and the scanning systems are demonstrated. 9 figs., 1 tab.

  5. Low-level laser therapy equipment needs calibration before clinical use

    Science.gov (United States)

    Machado de Senna, André; Machado-de-sena, Rosa Maria; Facundes, Arseni Lázaro; Barros Nepomuceno, Patrícia; Sávya Florentino, Wanilza; Olegário de Araújo, Ronyere

    2018-04-01

    Many factors can influence the radiant power delivered by the low-level laser therapy (LLLT) equipment, such as its cleaning and condition, as well as the use of plastic films for protecting the laser or even its time of use. Radiant power is an important factor to consider because it affects the amount of energy delivered to the target tissue. The difference between real radiant power (RRP) and nominal radiant power (NRP) may interfere in the expected results, because the delivered energy is different from the desired energy. Purpose: The objective of this study was to compare the NRP with the RRP offered by LLLT devices under clinical conditions of use. Material and Methods: For data collection to this study, 61 LLLT devices used in private and public dental practices in the state of Tocantins, Brazil, were evaluated. Three consecutive power measurements were performed at one-minute intervals and then the average of the measured power was calculated. The RRP was compared to the NRP. Results: The equipment presented NRP from 30 to 500mW while RRP ranged from 17.3 to 107.0mW. Discussion and Conclusion: The mean power measured in clinical conditions of use of the laser equipment was different from the nominal power reported by the manufacturers of the devices (p<0,01). The RRP ranged between 12.92% and 107% of NRP. This fact is worrisome, since one of the most important parameters for the success of the treatment of an injury using LLLT is the energy (power x time) delivered. These findings reinforce the need of calibrating the equipment before each laser application in order to avoid failures in the therapeutic conduct.

  6. Fuzzy Activity Based Life Cycle Costing For Repairable Equipment

    Directory of Open Access Journals (Sweden)

    Mulubrhan Freselam

    2016-01-01

    Full Text Available Life-cycle cost (LCC is the much known method used for decision making that considers all costs in the life of a system or equipment. Predicting LCCs is fraught with potential errors, owing to the uncertainty in future events, future costs, interest rates, and even hidden costs. These uncertainties have a direct impact on the decision making. Activity based LCC is used to identify the activities and cost drivers in acquisition, operation and maintenance phase. This activity based LCC is integrated with fuzzy set theory and interval mathematics to model these uncertainties. Day–Stout–Warren (DSW algorithm and the vertex method are then used to evaluate competing alternatives. A case of two pumps (Pump A and Pump B are taken and their LCC is analysed using the developed model. The equivalent annual cost of Pump B is greater than Pump A, which leads the decision maker to choose Pump A over Pump B.

  7. A problem-based learning curriculum for occupational therapy education.

    Science.gov (United States)

    Royeen, C B

    1995-04-01

    To prepare practitioners and researchers who are well equipped to deal with the inevitable myriad changes in health care and in society coming in the 21st century, a new focus is needed in occupational therapy education. In addition to proficiency in clinical skills and technical knowledge, occupational therapy graduates will need outcome competencies underlying the skills of critical reflection. In this article, the author presents (a) the rationale for the need for change in occupational therapy education, (b) key concepts of clinical reasoning and critical reflection pertaining to the outcome such change in occupational therapy education should address, (c) problem-based learning as a process and educational method to prepare occupational therapists in these competencies, and (d) the experience of the Program in Occupational Therapy at Shenandoah University in Winchester, Virginia, in implementing a problem-based learning curriculum.

  8. The one million volt X-ray therapy equipment at St Bartholomew's Hospital, 1936-1960

    International Nuclear Information System (INIS)

    Innes, G.S.

    1988-01-01

    St Bartholomew's Hospital in 1934 placed a contract with Messrs Metropolitan Vickers, of Manchester, for an X-ray therapy equipment to operate at 600 kV, 2mA d.c., but with the proviso that every effort would be made to attain an operating condition of 1000 kV, 4mA. The X-ray tube and rectifiers were to be continuously evacuated and demountable. This meant that components such as filaments, anodes and the target could be easily replaced, so providing cheap maintenance and continuous availability of the plant. No specification exists today, but one was assembled from the minutes of the Cancer Committee of the hospital and the contract pricing. A brief outline historical review is also presented, particularly of the personalities involved, and the War years 1939-1945. (author)

  9. The application of low lever laser therapy using equipment produced at CEADEN

    International Nuclear Information System (INIS)

    Orellana Molina, A.; Combarro Romero, A. M.; Morales Valdes, O.; Hernandez Diaz, A.; Corcho Corcho, C. A.; Fernandez Yanes, S.; Arteche Diaz, J.; Porrua Garcia, A.; Larrea Cox, P. J.

    2012-01-01

    The development of the use of light with medical purposes, constitute the fundamental basis for the introduction of the laser radiation in medicine. The magnificent results obtained and the amplification of the number of pathologies that can be treated with it, led to the introduction in 1985 of this technology in Cuban hospitals. However, the price of available commercial systems in the market was prohibitive for us, reason for which it was organized a national program that allowed the design and production of this kind of medical equipment, which is being carried out by our center (CEADEN). This technique is known as Low Level Laser Therapy (LLLT). Used for more than four decades, its main goal is to achieve beneficial effects on the human body, like analgesic and anti-inflammatory. It makes damaged soft tissues heal faster, offers a reparative effect on the nervous tissue, muscular tissue, soft tissue, and skin, tissue regeneration, cellular and mitochondrial ATP multiplication, increases the vascular activity, activates the immunological system, and so on. Laser therapy in Cuba has been used in different medical specialties. (Author)

  10. Photoelectric detectors used in laser based control and alignment equipment

    International Nuclear Information System (INIS)

    Chis, I.; Ciura, A.I.; Udrea, M.V.

    1988-03-01

    Some theoretical considerations and practical results regarding the utilization of the ROL 50 photovoltaic cell in a leveling control system and glass quality control equipment are presented. (authors)

  11. Calculation of the structural shielding of the radiotherapy treatment room equipped with a linear accelerator type Tomo therapy Hi-Art in the Oncology Center of Chihuahua, Mexico

    International Nuclear Information System (INIS)

    Caballero G, C. A.; Plascencia, J. C.; Vargas V, M. X.; Toledo J, P.

    2010-09-01

    The helicoid tomo therapy is an external radiotherapy system of modulated intensity, guided by image, in which the radiation is imparted to the patient using a narrow radiation beam in helicoid form, in a similar way to the scanning process with a computerized tomography. The tomo therapy equipment (Tomo Therapy Hi-Art) consists in an electrons linear accelerator with acceleration voltages of 6 MV for treatment and 3.5 MV for image, coupled to a ring that turn around the patient as this is transferred through this ring in perpendicular sense to the radiation beam. The radiation beam is narrow because has the maximum size of 5 x 40 cm 2 in the isocenter. The intensity modulation of the beam is carried out with a binary dynamic collimator of 64 crisscross sheets, and the guide by image though a system of megavoltage computerized tomography. Opposed to the radiation beam, also coupled to the rotational ring, a group of lead plates exists with a total thickness of 13 cm that acts as barrier of the primary radiation beam. The special configuration of the tomography equipment makes to have the following characteristics: 1) the presence of the lead barrier of the equipment reduces the intensity of the primary beam that reaches the bunker walls in considerable way, 2) the disperse and leakage radiations are increased with regard to a conventional accelerator due to the increase in the necessary irradiation time to produce modulated intensity fields by means of the narrow radiation beam. These special characteristics of the tomo therapy equipment make that particularities exist in the application of the formulations for structural shielding calculations that appears in the NCRP reports 49, NCRP 151 and IAEA-SRS-47. For this reason, several researches have development analytic models based on geometric considerations of continuous rotation of the equipment ring to determine the shielding requirements for the primary beam, the dispersed and leakage radiation in tomo therapy

  12. Physical therapy clinic therapeutic ultrasound equipment as a source for bacterial contamination.

    Science.gov (United States)

    Spratt, Henry G; Levine, David; Tillman, Larry

    2014-10-01

    A procedure commonly used in physical therapy (PT) clinics is therapeutic ultrasound (US). This equipment and associated gel comes in contact with patient skin, potentially serving as a reservoir for bacteria. In this study, we sampled US heads, gel bottle tips and gel from nine outpatient PT clinics in Southeastern Tennessee. Samples were collected using sterile swabs. At the microbiology laboratory, these swabs were used to inoculate mannitol salt agar and CHROM-MRSA agar (for Staphylococcal species) and tryptic soy broth to determine non-specific bacterial contamination. US heads, gel bottle tips and gel had variable levels of contamination. Tips of gel bottles had the highest contamination, with 52.7% positive for non-specific bacterial contamination and 3.6% positive for methicillin-resistant Staphylococcus aureus (MRSA). Contamination of gel by non-specific bacteria was found in 14.5% of bottles sampled. US heads (35.5% of those sampled) had non-specific bacterial contamination, with no MRSA detected. Disinfecting US heads after initial swabbing resulted in removal of 90.9% of non-specific contamination. Gel storage at temperatures below 40 °C was found to encourage the growth of mesophilic bacteria. This study demonstrates the need for better cleaning and storage protocols for US heads and gel bottles in PT clinics.

  13. Nuclear equipment recalsification based on the service experience

    International Nuclear Information System (INIS)

    Geambasu, A.; Segarceanu, D.

    2000-01-01

    The paper presents some considerations concerning the need of comparison between equipment performance proven by test and the service experience in Cernavoda Nuclear Plant. Service performance dana obtain partly from service failures (failures times) and partly from service experience without failure (running times) can be statistically analyzed to obtain predictions of the number of failures of unfailed units in specified period of time, means time to first failure, means time of median failure, a.s.o. These informations can be used during the operation of Nuclear Power Plant to estimate when a equipment should be replaced with a new one in order to prevent getting to the life end point. (author)

  14. Procedure for field axes measurement, beam indication adjustment, and figure of convergence determination within performance tests for radiation therapy equipment

    Energy Technology Data Exchange (ETDEWEB)

    Quast, U; Krause, K; Rassow, J [Essen Univ. (Gesamthochschule) (Germany, F.R.). Abt. fuer Klinische Strahlenphysik

    1976-09-01

    A routine measuring procedure for the verification of radiation field axes and figure of convergence within a spatial resolution of +- 0.5 mm is described. Measurements are done in two parallel planes in a certain distance before and behind the presumed isocentre. The used test arrangement permits rapid check and controlled adjustment of the alignment of beam or isocentre indicating devices for all isocentric radiation therapy equipment.

  15. Compliance to Standard Equipment Requirements by Exercise Therapy/Fitness Outfits in The South-South Geopolitical Zone of Nigeria

    Directory of Open Access Journals (Sweden)

    Oluwaseun S. Kubeyinje

    2016-08-01

    Full Text Available The purpose of this study was to assess the compliance of exercise therapy/fitness outfits in the south-south geopolitical zone of Nigeria to standard equipment requirements. Descriptive survey design was adopted for the conduct of the study using a sample size of 51centres/managers purposively selected from a population of 102 managers of fitness outfits in the six states of the south-south geopolitical zone of Nigeria. A self- developed structured questionnaire and a facility checklist were used to collect the data. Data collected were analysed using frequency counts and percentages. The study revealed in this analysis that only treadmills (66.7%, bicycle ergometers (66.7%, dumbbells (84.3% and weight racks (57.0% met the benchmark minimum in more than 50% of the exercise therapy/fitness outfits surveyed in six states of the south-south geopolitical zone of Nigeria. Most of the equipment surveyed were functional with the highest non-functionality occurring in treadmill machines in 9.8% of the surveyed centres followed by sit-up benches (5.9% and bicycle ergometers (3.9%. In conclusion, it could be deduced from the results that there’s gross inadequacy of equipment and low level of compliance to established standard in the exercise therapy/fitness outfits evaluated in the south-south geopolitical zone of Nigeria.

  16. Cell based therapy in Parkinsonism

    NARCIS (Netherlands)

    de Munter, J.P.J.M.; Lee, C.; Wolters, E.C.

    2013-01-01

    Parkinson's disease (PD) is a synucleinopathy-induced chronic progressive neurodegenerative disorder, worldwide affecting about 5 million humans. As of yet, actual therapies are symptomatic, and neuroprotective strategies are an unmet need. Due to their capability to transdifferentiate, to immune

  17. The equipment access software for a distributed UNIX-based accelerator control system

    International Nuclear Information System (INIS)

    Trofimov, Nikolai; Zelepoukine, Serguei; Zharkov, Eugeny; Charrue, Pierre; Gareyte, Claire; Poirier, Herve

    1994-01-01

    This paper presents a generic equipment access software package for a distributed control system using computers with UNIX or UNIX-like operating systems. The package consists of three main components, an application Equipment Access Library, Message Handler and Equipment Data Base. An application task, which may run in any computer in the network, sends requests to access equipment through Equipment Library calls. The basic request is in the form Equipment-Action-Data and is routed via a remote procedure call to the computer to which the given equipment is connected. In this computer the request is received by the Message Handler. According to the type of the equipment connection, the Message Handler either passes the request to the specific process software in the same computer or forwards it to a lower level network of equipment controllers using MIL1553B, GPIB, RS232 or BITBUS communication. The answer is then returned to the calling application. Descriptive information required for request routing and processing is stored in the real-time Equipment Data Base. The package has been written to be portable and is currently available on DEC Ultrix, LynxOS, HPUX, XENIX, OS-9 and Apollo domain. ((orig.))

  18. Supplier selection based on improved MOGA and its application in nuclear power equipment procurement

    International Nuclear Information System (INIS)

    Yan Zhaojun; Wang Dezhong; Zhou Lei

    2007-01-01

    Considering the fact that there are few objective and available methods supporting the supplier selection in nuclear power equipment purchasing process, a supplier selection method based on improved multi-objective genetic algorithm (MOGA) is proposed. The simulation results demonstrate the effectiveness and efficiency of this method for the supplier selection in nuclear power equipment procurement process. (authors)

  19. Liposome based radiosensitizer cancer therapy

    DEFF Research Database (Denmark)

    Pourhassan, Houman

    Liposome-encapsulated chemotherapeutics have been used in the treatment of a variety of cancers and are feasible for use as mono-therapeutics as well as for combination therapy in conjunction with other modalities. Despite widespread use of liposomal drugs in cancer patient care, insufficient drug...... biomolecules. By modulating the liposomal membrane, liposomes can become sensitive towards enzymatically-driven destabilization and/or functionalization, thereby allowing control of the release of encapsulated therapeutics within the diseased tissue upon intrinsic stimulation from tumor-associated enzymes...... in tumor-bearing mice.The safety and efficacy of sPLA2-sensitive liposomal L-OHP was assessed in sPLA2-deficient FaDu hypopharyngeal squamous cell carcinoma and sPLA2-expressing Colo205 colorectal adenocarcinoma. Also, the feasibility of multimodal cancer therapy employing L-OHP encapsulated in MMP...

  20. The helical tomo-therapy: appeal to projects Inca 2005 first assessment of the three equipped establishments

    International Nuclear Information System (INIS)

    Zefkili, S.; Francois, P.; Giraud, P.; Caron, J.; Dejean, C.; Kantor, G.; Munos, C.; Mahe, M.A.; Lisbona, A.

    2007-01-01

    The centers of fight against cancer ( C.L.C.C.) Institute Curie of Paris, Institute Bergonie of Bordeaux, Center Rene Gauducheau of Nantes have got to exploit the helical radiotherapy (tomo-therapy) in the frame of an appeal to projects launched in 2005 by the National Institute of cancer (I.n.c.a.) in relation with the innovating techniques in radiotherapy and presenting one of the measures of the Cancer plan 2003-2007. This communication constitutes a step report in the installation and use of equipments. (N.C.)

  1. NFC based Equipment Qualification Management (NEQM) system preventing counterfeit and fraudulent item

    Energy Technology Data Exchange (ETDEWEB)

    Chang, C.K., E-mail: ckchang@kings.ac.kr [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of); Lee, K.J., E-mail: klee@khu.ac.kr [Kyung Hee Univ., Seoul (Korea, Republic of)

    2014-07-01

    Qualification of equipment essential to safety in nuclear power plants (NPPs) ensures its capability to perform designated safety functions on demand under postulated service conditions. However, a number of incidents identified by the NRC since 1980s catalysed the US nuclear industry to adopt standard precautions to guard against counterfeit items. The purpose of this paper is to suggest the NFC (Near Field Communication) based equipment qualification management system preventing counterfeit and fraudulent items. The NEQM (NFC based Equipment Qualification Management) system work with the support of legacy systems such as PMS (Procurement Management System) and FMS (Facility management System). (author)

  2. NFC based Equipment Qualification Management (NEQM) system preventing counterfeit and fraudulent item

    International Nuclear Information System (INIS)

    Chang, C.K.; Lee, K.J.

    2014-01-01

    Qualification of equipment essential to safety in nuclear power plants (NPPs) ensures its capability to perform designated safety functions on demand under postulated service conditions. However, a number of incidents identified by the NRC since 1980s catalysed the US nuclear industry to adopt standard precautions to guard against counterfeit items. The purpose of this paper is to suggest the NFC (Near Field Communication) based equipment qualification management system preventing counterfeit and fraudulent items. The NEQM (NFC based Equipment Qualification Management) system work with the support of legacy systems such as PMS (Procurement Management System) and FMS (Facility management System). (author)

  3. Condition based monitoring, diagnosis and maintenance on operating equipments of a hydraulic generator unit

    International Nuclear Information System (INIS)

    Liu, X T; Feng, F Z; Si, A W

    2012-01-01

    According to performance characteristics of operating equipments in a hydraulic generator unit (HGU), the relative techniques on condition monitoring and fault diagnosis (CMFD) are introduced in this paper, especially the key technologies are emphasized, such as equipment monitoring, expert system (ES), intelligent diagnosis and condition based maintenance (CBM). Meanwhile, according to the instructor on CBM proposed by State electric power corporation, based on integrated mode, the main steps on implementation of CBM are discussed in this paper.

  4. Quality assurance study for dosimetry of Radiation Therapy equipment in Saudi Arabia

    International Nuclear Information System (INIS)

    Al-Mokhlef, Jazi M.; Nabaz, Noori

    2003-01-01

    International standards address the accuracy of dose delivery for radiation therapy machines as well as quality assurance and staffing levels for radiation therapy centers. We performed absolute calibrations of gamma ,X-ray and electron radiotherapy beams in all radiation therapy centers in Saudi Arabia. We also assessed quality assurance and staffing levels Dosimetric measurements were made with a portable dosimetry system, which consisted of a calibrated Farmer ionization chamber and an electrometer, small water phantom, barometer and thermometer. Differences between the measured and the expected output (c Gy/MU or c Gy/min) were found to be in the range of -11%+5%. About 17% of radiotherapy beams were not within the acceptable tolerance level (+/-3%). Quality assurance in some radiation centers was poor and staffing levels were inadequate. We found poor compliance with internationally accepted tolerance levels for dose calibration of radiotherapy beams at radiation therapy centers in Saudi Arabia. Analysis of medical physics staffing revealed severe discrepancies from those recommended by international guidelines .We recommend that radiation therapy centers be adequately staffed with qualified medical physics personnel and that periodic audit programs be required a governmental body. (author)

  5. Influence of various parameters on effectiveness of seismic base isolation of nuclear equipment

    International Nuclear Information System (INIS)

    Ebisawa, K.; Kameoka, H.; Takenouchi, I.; Kajiki, S.

    1995-01-01

    Authors developed a methodology and EBISA code for evaluating the applicability and the effectiveness of seismic base isolation of nuclear equipment. In order to investigate the influence of various parameters on the effectiveness of seismic base isolation, a sensitivity analysis was carried out for an emergency transformer with the base isolation devices. It was proved that seismic base isolation of equipment is very effective. This effectiveness can be influenced by the differences of the base isolation devices and the direction of the input seismic wave. (author). 7 refs., 3 figs., 3 tabs

  6. Dosimetric characterization of a 2-D array of 223 solid state detectors for daily morning checks in Tomo Therapy equipment

    International Nuclear Information System (INIS)

    Reyes S, U.; Sosa A, M.; Vega C, H. R.

    2015-10-01

    Tomo Therapy is a new technique for the cancer treatment; however, the equipment must meet nearly all mechanical and dosimetric characteristics of a conventional linear accelerator for medical use. Daily quality controls are vital to the good operation of the equipment and thus guarantee excellent quality in the daily delivery of treatments. This paper presents the procedure of the dosimetric characterization of a two-dimensional array of 223 solid state detectors, called TomoDose of the Sun Nuclear Company. Dosimetric important criteria are established to perform these checks quickly and accurately. Dosimetric tests proposed are: repeatability, linearity, dependence of Sad and SSD. Some results are compared with readings of the ionization chamber Exradim A1SL. Finally the results of 30 consecutive days are presented to establish criteria for evidence of dose, field size, symmetry and flattening of the radiation beam on Tomo Therapy equipment. Expected values for daily verification are: Dose constancy of 194.89 c Gy, σ= 1.31 c Gy, symmetry in the X axis of -0.19 %, σ=0.08 %, symmetry in the Y axis of 1.66 %, σ= 0.05 %, flattened in the X axis of 25.71 %, σ= 0.05 % and flattened in the Y axis of 6.41 %, σ= 10.23 %. Field sizes obtained were 40.45 cm in the X axis and 5.10 on the Y axis, with standard deviations of 0.02 cm and 0.01 cm, respectively. TomoDose dosimetric values, compared to the values obtained with ionization chamber, presented differences smaller than 2%. (Author)

  7. An open software system based on X Windows for process control and equipment monitoring

    International Nuclear Information System (INIS)

    Aimar, A.; Carlier, E.; Mertens, V.

    1992-01-01

    The construction and application of a configurable open software system for process control and equipment monitoring can speed up and simplify the development and maintenance of equipment specific software as compared to individual solutions. The present paper reports the status of such an approach for the distributed control systems of SPS and LEP beam transfer components, based on X Windows and the OSF/Motif tool kit and applying data modeling and software engineering methods. (author)

  8. Data communication between data terminal equipment and the JPL administrative data base management system

    Science.gov (United States)

    Iverson, R. W.

    1984-01-01

    Approaches to enabling an installed base of mixed data terminal equipment to access a data base management system designed to work with a specific terminal are discussed. The approach taken by the Jet Propulsion Laboratory is described. Background information on the Jet Propulsion Laboratory (JPL), its organization and a description of the Administrative Data Base Management System is included.

  9. A strategy for implementation of experience based seismic equipment qualification in IEEE and ASME industry standards

    International Nuclear Information System (INIS)

    Adams, T.M.

    1996-01-01

    In the past 20 years, extensive data on the performance of mechanical and electric equipment during actual strong motion earthquakes and seismic qualification tests has been accumulated. Recognizing that an experience based approach provides a technically sound and cost effective method for the seismic qualification of some or certain equipment, the IEEE Nuclear Power Engineering Committee and the ASME Committee on Qualification of Mechanical Equipment established a Special Working Group to investigate the incorporation of experienced based methods into the industry consensus codes and standards currently used in the seismic qualification of Seismic Category Nuclear Power Plant equipment. This paper presents the strategy (course of action) which was developed by the Special Working Group for meeting this objective of incorporation of experience based seismic qualification standards used in the design and seismic qualification of seismic category nuclear power plant equipment. This strategy was recommended to both chartering organizations, the IEEE Nuclear Power Engineering Committee and the ASME Committee on Qualification of Mechanical Equipment for their consideration and implementation. The status of the review and implementation of the Special Working Group's recommended strategy by the sponsoring organization is also discussed

  10. Nanotechnology for Cancer Therapy Based on Chemotherapy

    Directory of Open Access Journals (Sweden)

    Chen-Yang Zhao

    2018-04-01

    Full Text Available Chemotherapy has been widely applied in clinics. However, the therapeutic potential of chemotherapy against cancer is seriously dissatisfactory due to the nonspecific drug distribution, multidrug resistance (MDR and the heterogeneity of cancer. Therefore, combinational therapy based on chemotherapy mediated by nanotechnology, has been the trend in clinical research at present, which can result in a remarkably increased therapeutic efficiency with few side effects to normal tissues. Moreover, to achieve the accurate pre-diagnosis and real-time monitoring for tumor, the research of nano-theranostics, which integrates diagnosis with treatment process, is a promising field in cancer treatment. In this review, the recent studies on combinational therapy based on chemotherapy will be systematically discussed. Furthermore, as a current trend in cancer treatment, advance in theranostic nanoparticles based on chemotherapy will be exemplified briefly. Finally, the present challenges and improvement tips will be presented in combination therapy and nano-theranostics.

  11. A Model of Intelligent Fault Diagnosis of Power Equipment Based on CBR

    Directory of Open Access Journals (Sweden)

    Gang Ma

    2015-01-01

    Full Text Available Nowadays the demand of power supply reliability has been strongly increased as the development within power industry grows rapidly. Nevertheless such large demand requires substantial power grid to sustain. Therefore power equipment’s running and testing data which contains vast information underpins online monitoring and fault diagnosis to finally achieve state maintenance. In this paper, an intelligent fault diagnosis model for power equipment based on case-based reasoning (IFDCBR will be proposed. The model intends to discover the potential rules of equipment fault by data mining. The intelligent model constructs a condition case base of equipment by analyzing the following four categories of data: online recording data, history data, basic test data, and environmental data. SVM regression analysis was also applied in mining the case base so as to further establish the equipment condition fingerprint. The running data of equipment can be diagnosed by such condition fingerprint to detect whether there is a fault or not. Finally, this paper verifies the intelligent model and three-ratio method based on a set of practical data. The resulting research demonstrates that this intelligent model is more effective and accurate in fault diagnosis.

  12. Prediction degradation trend of nuclear equipment based on GM (1, 1)-Markov chain

    International Nuclear Information System (INIS)

    Zhang Liming; Zhao Xinwen; Cai Qi; Wu Guangjiang

    2010-01-01

    The degradation trend prediction results are important references for nuclear equipment in-service inspection and maintenance plan. But it is difficult to predict the nuclear equipment degradation trend accurately by the traditional statistical probability due to the small samples, lack of degradation data and the wavy degradation locus. Therefore, a method of equipment degradation trend prediction based on GM (1, l)-Markov chain was proposed in this paper. The method which makes use of the advantages of both GM (1, 1) method and Markov chain could improve the prediction precision of nuclear equipment degradation trend. The paper collected degradation data as samples and accurately predicted the degradation trend of canned motor pump. Compared with the prediction results by GM (1, 1) method, the prediction precision by GM (1, l)-Markov chain is more accurate. (authors)

  13. Equipment Maintenance management support system based on statistical analysis of maintenance history data

    International Nuclear Information System (INIS)

    Shimizu, S.; Ando, Y.; Morioka, T.

    1990-01-01

    Plant maintenance is recently becoming important with the increase in the number of nuclear power stations and in plant operating time. Various kinds of requirements for plant maintenance, such as countermeasures for equipment degradation and saving maintenance costs while keeping up plant reliability and productivity, are proposed. For this purpose, plant maintenance programs should be improved based on equipment reliability estimated by field data. In order to meet these requirements, it is planned to develop an equipment maintenance management support system for nuclear power plants based on statistical analysis of equipment maintenance history data. The large difference between this proposed new method and current similar methods is to evaluate not only failure data but maintenance data, which includes normal termination data and some degree of degradation or functional disorder data for equipment and parts. So, it is possible to utilize these field data for improving maintenance schedules and to evaluate actual equipment and parts reliability under the current maintenance schedule. In the present paper, the authors show the objectives of this system, an outline of this system and its functions, and the basic technique for collecting and managing of maintenance history data on statistical analysis. It is shown, from the results of feasibility tests using simulation data of maintenance history, that this system has the ability to provide useful information for maintenance and the design enhancement

  14. Therapy for obesity based on gastrointestinal hormones

    DEFF Research Database (Denmark)

    Bagger, Jonatan I; Christensen, Mikkel; Knop, Filip K

    2011-01-01

    for the treatment of type 2 diabetes. In contrast to other antidiabetic treatments, these agents have a positive outcome profile on body weight. Worldwide there are 500 million obese people, and 3 million are dying every year from obesity-related diseases. Recently, incretin-based therapy was proposed...... for the treatment of obesity. Currently two different incretin therapies are widely used in the treatment of type 2 diabetes: 1) the GLP-1 receptor agonists which cause significant and sustained weight loss in overweight patients, and 2) dipeptidyl peptidase 4 (DPP-4) inhibitors being weight neutral. These findings...... have led to a greater interest in the physiology of intestinal peptides with potential weight-reducing properties. This review discusses the effects of the incretin-based therapies in obesity, and provides an overview of intestinal peptides with promising effects as potential new treatments for obesity....

  15. Review of Real-Time 3-Dimensional Image Guided Radiation Therapy on Standard-Equipped Cancer Radiation Therapy Systems: Are We at the Tipping Point for the Era of Real-Time Radiation Therapy?

    Science.gov (United States)

    Keall, Paul J; Nguyen, Doan Trang; O'Brien, Ricky; Zhang, Pengpeng; Happersett, Laura; Bertholet, Jenny; Poulsen, Per R

    2018-04-14

    To review real-time 3-dimensional (3D) image guided radiation therapy (IGRT) on standard-equipped cancer radiation therapy systems, focusing on clinically implemented solutions. Three groups in 3 continents have clinically implemented novel real-time 3D IGRT solutions on standard-equipped linear accelerators. These technologies encompass kilovoltage, combined megavoltage-kilovoltage, and combined kilovoltage-optical imaging. The cancer sites treated span pelvic and abdominal tumors for which respiratory motion is present. For each method the 3D-measured motion during treatment is reported. After treatment, dose reconstruction was used to assess the treatment quality in the presence of motion with and without real-time 3D IGRT. The geometric accuracy was quantified through phantom experiments. A literature search was conducted to identify additional real-time 3D IGRT methods that could be clinically implemented in the near future. The real-time 3D IGRT methods were successfully clinically implemented and have been used to treat more than 200 patients. Systematic target position shifts were observed using all 3 methods. Dose reconstruction demonstrated that the delivered dose is closer to the planned dose with real-time 3D IGRT than without real-time 3D IGRT. In addition, compromised target dose coverage and variable normal tissue doses were found without real-time 3D IGRT. The geometric accuracy results with real-time 3D IGRT had a mean error of real-time 3D IGRT methods using standard-equipped radiation therapy systems that could also be clinically implemented. Multiple clinical implementations of real-time 3D IGRT on standard-equipped cancer radiation therapy systems have been demonstrated. Many more approaches that could be implemented were identified. These solutions provide a pathway for the broader adoption of methods to make radiation therapy more accurate, impacting tumor and normal tissue dose, margins, and ultimately patient outcomes. Copyright © 2018

  16. Development of the New Kibou® Equipment for Continuous Renal Replacement Therapy from Scratch to the Final Configuration.

    Science.gov (United States)

    Neri, Mauro; Lorenzin, Anna; Brendolan, Alessandra; Garzotto, Francesco; Ferrari, Fiorenza; De Rosa, Silvia; Bonato, Raffaele; Villa, Gianluca; Bazzano, Simona; D''Ippoliti, Fiorella; Ricci, Zaccaria; La Manna, Gaetano; Ronco, Claudio

    2017-01-01

    A new technology has recently appeared in the area of extracorporeal therapies for critically ill patients with acute kidney injury. The International Renal Research Institute of Vicenza was involved from the beginning in the development of a new continuous renal replacement therapy (CRRT) equipment with peculiar characteristics. We report the overall experience from design of the new machine to its in vitro and in vivo testing. Kibou® (Asahi Kasei Kuraray Medical Co., Ltd., Tokyo, Japan) is a new multifunctional machine designed for delivering RRT. Kibou® carries out many features of the fourth generation CRRT machines including the possibility of a dynamic prescription and reduction of nursing workload. We describe our first experience with this new device, focusing on several usability and performance parameters. A specific in vitro protocol was designed to analyze the various characteristics and accuracy of performance of the machine. Furthermore, a preliminary in vivo alpha trial with 12 CRRT sessions was performed to test, characterize and evaluate the machine in terms of usability, flexibility and reliability. The in vitro evaluation confirmed an adequate design and a good usability of the machine with accurate delivery of prescribed parameters. No adverse events were observed during the in vivo test that confirmed usability and safety together with accuracy of treatment delivery in different modalities. In general, the machine was rated by physicians and nurses involved in the evaluation as practical and easy to use, although a specific training is required to familiarize with the equipment. A large-scale multicenter beta trial is required to confirm the results reported in this preliminary evaluation in terms of safety, accuracy and performance of Kibou®. © 2017 S. Karger AG, Basel.

  17. Therapy for obesity based on gastrointestinal hormones

    DEFF Research Database (Denmark)

    Bagger, Jonatan I; Christensen, Mikkel; Knop, Filip K

    2011-01-01

    It has long been known that peptide hormones from the gastrointestinal tract have significant impact on the regulation of nutrient metabolism. Among these hormones, incretins have been found to increase insulin secretion, and thus incretin-based therapies have emerged as new modalities...

  18. RNA-based therapies for genodermatoses

    NARCIS (Netherlands)

    Bornert, Olivier; Peking, Patricia; Bremer, Jeroen; Koller, Ulrich; van den Akker, Peter C.; Aartsma-Rus, Annemieke; Pasmooij, Anna M. G.; Murauer, Eva M.; Nystroem, Alexander

    Genetic disorders affecting the skin, genodermatoses, constitute a large and heterogeneous group of diseases, for which treatment is generally limited to management of symptoms. RNA-based therapies are emerging as a powerful tool to treat genodermatoses. In this review, we discuss in detail RNA

  19. A prediction method based on grey system theory in equipment condition based maintenance

    International Nuclear Information System (INIS)

    Yan, Shengyuan; Yan, Shengyuan; Zhang, Hongguo; Zhang, Zhijian; Peng, Minjun; Yang, Ming

    2007-01-01

    Grey prediction is a modeling method based on historical or present, known or indefinite information, which can be used for forecasting the development of the eigenvalues of the targeted equipment system and setting up the model by using less information. In this paper, the postulate of grey system theory, which includes the grey generating, the sorts of grey generating and the grey forecasting model, is introduced first. The concrete application process, which includes the grey prediction modeling, grey prediction, error calculation, equal dimension and new information approach, is introduced secondly. Application of a so-called 'Equal Dimension and New Information' (EDNI) technology in grey system theory is adopted in an application case, aiming at improving the accuracy of prediction without increasing the amount of calculation by replacing old data with new ones. The proposed method can provide a new way for solving the problem of eigenvalue data exploding in equal distance effectively, short time interval and real time prediction. The proposed method, which was based on historical or present, known or indefinite information, was verified by the vibration prediction of induced draft fan of a boiler of the Yantai Power Station in China, and the results show that the proposed method based on grey system theory is simple and provides a high accuracy in prediction. So, it is very useful and significant to the controlling and controllable management in safety production. (authors)

  20. A New Method of Reliability Evaluation Based on Wavelet Information Entropy for Equipment Condition Identification

    International Nuclear Information System (INIS)

    He, Z J; Zhang, X L; Chen, X F

    2012-01-01

    Aiming at reliability evaluation of condition identification of mechanical equipment, it is necessary to analyze condition monitoring information. A new method of reliability evaluation based on wavelet information entropy extracted from vibration signals of mechanical equipment is proposed. The method is quite different from traditional reliability evaluation models that are dependent on probability statistics analysis of large number sample data. The vibration signals of mechanical equipment were analyzed by means of second generation wavelet package (SGWP). We take relative energy in each frequency band of decomposed signal that equals a percentage of the whole signal energy as probability. Normalized information entropy (IE) is obtained based on the relative energy to describe uncertainty of a system instead of probability. The reliability degree is transformed by the normalized wavelet information entropy. A successful application has been achieved to evaluate the assembled quality reliability for a kind of dismountable disk-drum aero-engine. The reliability degree indicates the assembled quality satisfactorily.

  1. Research on Health State Perception Algorithm of Mining Equipment Based on Frequency Closeness

    Directory of Open Access Journals (Sweden)

    Gang Wang

    2014-06-01

    Full Text Available The health state perception of mining equipment is intended to have an online real- time knowledge and analysis of the running conditions of large mining equipments. Due to its unknown failure mode, a challenge was raised to the traditional fault diagnosis of mining equipments. A health state perception algorithm of mining equipment was introduced in this paper, and through continuous sampling of the machine vibration data, the time-series data set was set up; subsequently, the mode set based on the frequency closeness was constructed by the d neighborhood method combined with the TSDM algorithm, thus the forecast method on the basis of the dual mode set was eventually formed. In the calculation of the frequency closeness, the Goertzel algorithm was introduced to effectively decrease the computation amount. It was indicated through the simulation test on the vibration data of the drum shaft base that the health state of the device could be effectively distinguished. The algorithm has been successfully applied to equipment monitoring in the Huoer Xinhe Coal Mine of Shanxi Coal Imp&Exp. Group Co., Ltd.

  2. A Method of Numerical Control Equipment Appearance Design Based on Product Identity

    Science.gov (United States)

    Zhu, Zhijuan; Zhou, Qi; Li, Bin; Visser, Steve

    Research on numerical control (NC) equipment has been more and more abundant; however, there are few existing studies in the field of appearance design for NC equipments. This paper provided a method to generate new appearance design of NC equipments based on product identity (PI). For the purpose of providing guidelines to generate new concept of NC equipment design, this paper, therefore, took the DMG Company (a Germen NC equipment company) as a case, examined the total products of this company from two aspects: Product Image and Product Family. Task 1 was an evaluate task about the Product Image by using the semantic differential (SD) evaluation method; Task 2 was a study task about Product Family to find out features of the products and classify these features. During the Task 2, several features have been found out and summarized, and these features were classified into 3 different levels according to their frequency and importance. In the end, two appearance design samples have been generated based on the analysis above to prove the application of the research.

  3. Application of electron beam equipment based on a plasma cathode gun in additive technology

    Science.gov (United States)

    Galchenko, N. K.; Kolesnikova, K. A.; Semenov, G. V.; Rau, A. G.; Raskoshniy, S. Y.; Bezzubko, A. V.; Dampilon, B. V.; Sorokova, S. N.

    2016-11-01

    The paper discusses the application of electron beam equipment based on a plasma cathode gun for three-dimensional surface modification of metals and alloys. The effect of substrate surface preparation on the adhesion strength of gas thermal coatings has been investigated.

  4. The basic discussion on nuclear power safety improvement based on nuclear equipment design

    International Nuclear Information System (INIS)

    Zhao Feiyun; Yao Yangui; Yu Hao; He Yinbiao; Gao Lei; Yao Weida

    2013-01-01

    The safety of strengthening nuclear power design was described based on nuclear equipment design after Fukushima nuclear accident. From these aspects, such as advanced standard system, advanced design method, suitable test means, consideration of beyond design basis event, and nuclear safety culture construction, the importance of nuclear safety improvement was emphatically presented. The enlightenment was given to nuclear power designer. (authors)

  5. Design and implement of mobile equipment management system based on QRcode

    Science.gov (United States)

    Yu, Runze; Duan, Xiaohui; Jiao, Bingli

    2017-08-01

    A mobile equipment management system based on QRcode is proposed for remote and convenient device management. Unlike conventional systems, the system here makes managers accessible to real-time information with smart phones. Compared with the conventional method, which can only be operated with specific devices, this lightweight and efficient tele management mode is conducive to the asset management in multiple scenarios.

  6. Prior use of durable medical equipment as a risk adjuster for health-based capitation

    NARCIS (Netherlands)

    R.C. van Kleef (Richard); R.C.J.A. van Vliet (René)

    2010-01-01

    textabstractThis paper examines a new risk adjuster for capitation payments to Dutch health plans, based on the prior use of durable medical equipment (DME). The essence is to classify users of DME in a previous year into clinically homogeneous classes and to apply the resulting classification as a

  7. Virtual age model for equipment aging plant based on operation environment and service state

    International Nuclear Information System (INIS)

    Zhang Liming; Cai Qi; Zhao Xinwen; Chen Ling

    2010-01-01

    The accelerated life model based on the operation environment and service state was established by taking the virtual age as the equipment aging indices. The effect of different operation environments and service states on the reliability and virtual age under the continuum operation conditions and cycle operation conditions were analyzed, and the sensitivities of virtual age on operational environments and service states were studied. The results of the example application show that the effect of NPP equipment lifetime and the key parameters related to the reliability can be quantified by this model, and the result is in accordance with the reality.(authors)

  8. Research on Integrated Analysis Method for Equipment and Tactics Based on Intervention Strategy Discussion

    Institute of Scientific and Technical Information of China (English)

    陈超; 张迎新; 毛赤龙

    2012-01-01

    As the increase of the complexity of the information warfare,its intervention strategy needs to be designed in an integrated environment.However,the current research always breaks the internal relation between equipment and tactics,and it is difficult to meet the requirements of their integrated analysis.In this paper,the research status quo of the integrated analysis about equipment and tactics is discussed first,some shortages of the current methods are summarized then,and an evolvement mechanism of the integrated analysis for equipment and tactics is given finally.Based on these,a framework of integrated analysis is proposed.This method's effectiveness is validated by an example.

  9. [Development of a medical equipment support information system based on PDF portable document].

    Science.gov (United States)

    Cheng, Jiangbo; Wang, Weidong

    2010-07-01

    According to the organizational structure and management system of the hospital medical engineering support, integrate medical engineering support workflow to ensure the medical engineering data effectively, accurately and comprehensively collected and kept in electronic archives. Analyse workflow of the medical, equipment support work and record all work processes by the portable electronic document. Using XML middleware technology and SQL Server database, complete process management, data calculation, submission, storage and other functions. The practical application shows that the medical equipment support information system optimizes the existing work process, standardized and digital, automatic and efficient orderly and controllable. The medical equipment support information system based on portable electronic document can effectively optimize and improve hospital medical engineering support work, improve performance, reduce costs, and provide full and accurate digital data

  10. Nanotechnology for Cancer Therapy Based on Chemotherapy

    OpenAIRE

    Chen-Yang Zhao; Rui Cheng; Zhe Yang; Zhong-Min Tian

    2018-01-01

    Chemotherapy has been widely applied in clinics. However, the therapeutic potential of chemotherapy against cancer is seriously dissatisfactory due to the nonspecific drug distribution, multidrug resistance (MDR) and the heterogeneity of cancer. Therefore, combinational therapy based on chemotherapy mediated by nanotechnology, has been the trend in clinical research at present, which can result in a remarkably increased therapeutic efficiency with few side effects to normal tissues. Moreover,...

  11. Analysis of the computational methods on the equipment shock response based on ANSYS environments

    International Nuclear Information System (INIS)

    Wang Yu; Li Zhaojun

    2005-01-01

    With the developments and completions of equipment shock vibration theory, math calculation method simulation technique and other aspects, equipment shock calculation methods are gradually developing form static development to dynamic and from linearity to non-linearity. Now, the equipment shock calculation methods applied worldwide in engineering practices mostly include equivalent static force method, Dynamic Design Analysis Method (abbreviated to DDAM) and real-time simulation method. The DDAM is a method based on the modal analysis theory, which inputs the shock design spectrum as shock load and gets hold of the shock response of the integrated system by applying separate cross-modal integrating method within the frequency domain. The real-time simulation method is to carry through the computational analysis of the equipment shock response within the time domain, use the time-history curves obtained from real-time measurement or spectrum transformation as the equipment shock load and find an iterative solution of a differential equation of the system movement by using the computational procedure within the time domain. Conclusions: Using the separate DDAM and Real-time Simulation Method, this paper carried through the shock analysis of a three-dimensional frame floating raft in ANSYS environments, analyzed the result, and drew the following conclusion: Because DDAM does not calculate damping, non-linear effect and phase difference between mode responses, the result is much bigger than that of real-time simulation method. The coupling response is much complex when the mode result of 3-dimension structure is being calculated, and the coupling response of non-shock direction is also much bigger than that of real-time simulation method when DDAM is applied. Both DDAM and real-time simulation method has its good points and scope of application. The designers should select the design method that is economic and in point according to the features and anti

  12. Transfer of Minibeam Radiation Therapy into a cost-effective equipment for radiobiological studies: a proof of concept.

    Science.gov (United States)

    Prezado, Y; Dos Santos, M; Gonzalez, W; Jouvion, G; Guardiola, C; Heinrich, S; Labiod, D; Juchaux, M; Jourdain, L; Sebrie, C; Pouzoulet, F

    2017-12-11

    Minibeam radiation therapy (MBRT) is an innovative synchrotron radiotherapy technique able to shift the normal tissue complication probability curves to significantly higher doses. However, its exploration was hindered due to the limited and expensive beamtime at synchrotrons. The aim of this work was to develop a cost-effective equipment to perform systematic radiobiological studies in view of MBRT. Tumor control for various tumor entities will be addressable as well as studies to unravel the distinct biological mechanisms involved in normal and tumor tissues responses when applying MBRT. With that aim, a series of modifications of a small animal irradiator were performed to make it suitable for MBRT experiments. In addition, the brains of two groups of rats were irradiated. Half of the animals received a standard irradiation, the other half, MBRT. The animals were followed-up for 6.5 months. Substantial brain damage was observed in the group receiving standard RT, in contrast to the MBRT group, where no significant lesions were observed. This work proves the feasibility of the transfer of MBRT outside synchrotron sources towards a small animal irradiator.

  13. Aferição dos equipamentos de laser de baixa intensidade Calibration of low-level laser therapy equipment

    Directory of Open Access Journals (Sweden)

    Thiago Y. Fukuda

    2010-08-01

    Full Text Available CONTEXTUALIZAÇÃO: A laserterapia de baixa intensidade (LBI vem sendo cada vez mais utilizada, porém ainda não há consenso na literatura quanto ao tempo em que os equipamentos devem ser submetidos à aferição ou calibragem. OBJETIVO: Analisar a potência média real (PmR dos equipamentos de LBI na região da Grande São Paulo. MÉTODOS: Para análise dos equipamentos, utilizou-se um potenciômetro (Lasercheck, próprio para aferição de equipamentos contínuos, o qual foi programado com dados referentes ao comprimento de onda do laser a ser avaliado, obtendo-se assim a PmR emitida. Os equipamentos foram analisados de duas formas: uma, com o LBI desaquecido, e outra, após 10 minutos de uso (aquecido, sendo que três análises foram feitas para cada condição. A caneta emissora foi acoplada ao potenciômetro, o qual fornecia a PmR emitida pelo LBI. Todos os dados e informações referentes à aplicação do laser foram coletados por um questionário respondido pelos responsáveis. RESULTADOS: Os 60 equipamentos avaliados mostraram déficit na PmR com os equipamentos desaquecidos e aquecidos. A análise estatística (ANOVA mostrou diminuição significativa (PBACKGROUND: Despite the increase in the use of low-level laser therapy (LLLT, there is still a lack of consensus in the literature regarding how often the equipment must be calibrated. OBJECTIVE: To evaluate the real average power of LLLT devices in the Greater São Paulo area. METHODS: For the evaluation, a LaserCheck power meter designed to calibrate continuous equipment was used. The power meter was programmed with data related to the laser's wavelength to gauge the real average power being emitted. The LLLT devices were evaluated in two ways: first with the device cooled down and then with the device warmed up for 10 minutes. For each condition, three tests were performed. The laser probe was aligned with the power meter, which provided the real average power being emitted by the

  14. GRAPH-BASED POST INCIDENT INTERNAL AUDIT METHOD OF COMPUTER EQUIPMENT

    Directory of Open Access Journals (Sweden)

    I. S. Pantiukhin

    2016-05-01

    Full Text Available Graph-based post incident internal audit method of computer equipment is proposed. The essence of the proposed solution consists in the establishing of relationships among hard disk damps (image, RAM and network. This method is intended for description of information security incident properties during the internal post incident audit of computer equipment. Hard disk damps receiving and formation process takes place at the first step. It is followed by separation of these damps into the set of components. The set of components includes a large set of attributes that forms the basis for the formation of the graph. Separated data is recorded into the non-relational database management system (NoSQL that is adapted for graph storage, fast access and processing. Damps linking application method is applied at the final step. The presented method gives the possibility to human expert in information security or computer forensics for more precise, informative internal audit of computer equipment. The proposed method allows reducing the time spent on internal audit of computer equipment, increasing accuracy and informativeness of such audit. The method has a development potential and can be applied along with the other components in the tasks of users’ identification and computer forensics.

  15. Condition Evaluation of Storage Equipment Based on Improved D-S Evidence Theory

    Directory of Open Access Journals (Sweden)

    Zhang Xiao-yu

    2017-01-01

    Full Text Available Assessment and prediction of the storage equipment’s condition is always a difficult aspect in PHM technology. The current Condition evaluation of equipment lacks of the state level, and a single test data can’t reflect the change of equipment’s state. To solve the problem, this paper proposes an evaluation method based on improved D-S evidence theory. Firstly, use analytic hierarchy process (AHP to establish a hierarchical structure model of equipment and divide the qualified state into 4 grades. Then respectively compare the test data with the last test value, historical test mean value and standard value. And the triangular fuzzy function to calculate the index membership degree, combined with D-S evidence theory to fuse information from multiple sources, to achieve such equipment real-time state assessment. Finally, the model is used to a servo mechanism. The result shows that this method has a good performance in condition evaluation for the storage equipment

  16. Comprehensive analysis and evaluation of big data for main transformer equipment based on PCA and Apriority

    Science.gov (United States)

    Guo, Lijuan; Yan, Haijun; Hao, Yongqi; Chen, Yun

    2018-01-01

    With the power supply level of urban power grid toward high reliability development, it is necessary to adopt appropriate methods for comprehensive evaluation of existing equipment. Considering the wide and multi-dimensional power system data, the method of large data mining is used to explore the potential law and value of power system equipment. Based on the monitoring data of main transformer and the records of defects and faults, this paper integrates the data of power grid equipment environment. Apriori is used as an association identification algorithm to extract the frequent correlation factors of the main transformer, and the potential dependence of the big data is analyzed by the support and confidence. Then, the integrated data is analyzed by PCA, and the integrated quantitative scoring model is constructed. It is proved to be effective by using the test set to validate the evaluation algorithm and scheme. This paper provides a new idea for data fusion of smart grid, and provides a reference for further evaluation of big data of power grid equipment.

  17. Evidence-Based Management of Anticoagulant Therapy

    Science.gov (United States)

    Schulman, Sam; Witt, Daniel M.; Vandvik, Per Olav; Fish, Jason; Kovacs, Michael J.; Svensson, Peter J.; Veenstra, David L.; Crowther, Mark; Guyatt, Gordon H.

    2012-01-01

    Background: High-quality anticoagulation management is required to keep these narrow therapeutic index medications as effective and safe as possible. This article focuses on the common important management questions for which, at a minimum, low-quality published evidence is available to guide best practices. Methods: The methods of this guideline follow those described in Methodology for the Development of Antithrombotic Therapy and Prevention of Thrombosis Guidelines: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines in this supplement. Results: Most practical clinical questions regarding the management of anticoagulation, both oral and parenteral, have not been adequately addressed by randomized trials. We found sufficient evidence for summaries of recommendations for 23 questions, of which only two are strong rather than weak recommendations. Strong recommendations include targeting an international normalized ratio of 2.0 to 3.0 for patients on vitamin K antagonist therapy (Grade 1B) and not routinely using pharmacogenetic testing for guiding doses of vitamin K antagonist (Grade 1B). Weak recommendations deal with such issues as loading doses, initiation overlap, monitoring frequency, vitamin K supplementation, patient self-management, weight and renal function adjustment of doses, dosing decision support, drug interactions to avoid, and prevention and management of bleeding complications. We also address anticoagulation management services and intensive patient education. Conclusions: We offer guidance for many common anticoagulation-related management problems. Most anticoagulation management questions have not been adequately studied. PMID:22315259

  18. Control of equipment isolation system using wavelet-based hybrid sliding mode control

    Science.gov (United States)

    Huang, Shieh-Kung; Loh, Chin-Hsiung

    2017-04-01

    Critical non-structural equipment, including life-saving equipment in hospitals, circuit breakers, computers, high technology instrumentations, etc., is vulnerable to strong earthquakes, and on top of that, the failure of the vibration-sensitive equipment will cause severe economic loss. In order to protect vibration-sensitive equipment or machinery against strong earthquakes, various innovative control algorithms are developed to compensate the internal forces that to be applied. These new or improved control strategies, such as the control algorithms based on optimal control theory and sliding mode control (SMC), are also developed for structures engineering as a key element in smart structure technology. The optimal control theory, one of the most common methodologies in feedback control, finds control forces through achieving a certain optimal criterion by minimizing a cost function. For example, the linear-quadratic regulator (LQR) was the most popular control algorithm over the past three decades, and a number of modifications have been proposed to increase the efficiency of classical LQR algorithm. However, except to the advantage of simplicity and ease of implementation, LQR are susceptible to parameter uncertainty and modeling error due to complex nature of civil structures. Different from LQR control, a robust and easy to be implemented control algorithm, SMC has also been studied. SMC is a nonlinear control methodology that forces the structural system to slide along surfaces or boundaries; hence this control algorithm is naturally robust with respect to parametric uncertainties of a structure. Early attempts at protecting vibration-sensitive equipment were based on the use of existing control algorithms as described above. However, in recent years, researchers have tried to renew the existing control algorithms or developing a new control algorithm to adapt the complex nature of civil structures which include the control of both structures and non

  19. Effectiveness of mat Pilates or equipment-based Pilates exercises in patients with chronic nonspecific low back pain: a randomized controlled trial.

    Science.gov (United States)

    da Luz, Maurício Antônio; Costa, Leonardo Oliveira Pena; Fuhro, Fernanda Ferreira; Manzoni, Ana Carolina Taccolini; Oliveira, Naiane Teixeira Bastos; Cabral, Cristina Maria Nunes

    2014-05-01

    The Pilates method has been widely used to treat patients with chronic low back pain. Pilates exercises can be performed in 2 ways: by using specific equipment or without it (also known as mat Pilates). There are no studies, however, that have compared the effectiveness of mat Pilates with that of equipment-based Pilates. The aim of this study was to compare the effectiveness of mat Pilates and equipment-based Pilates in patients with chronic nonspecific low back pain. A 2-arm randomized controlled trial with a blinded assessor was conducted. The study was conducted at a private physical therapy clinic in Brazil. Eighty-six patients with chronic nonspecific low back pain participated. The patients were randomly allocated to 1 of 2 groups: a mat Pilates group (n=43) and an equipment-based Pilates group (n=43). The participants in both groups attended 12 Pilates sessions over a period of 6 weeks. The primary outcomes were pain intensity and disability. The secondary outcomes were global perceived effect, patient's specific disability, and kinesiophobia. A blinded assessor evaluated the outcomes at baseline and 6 weeks and 6 months after randomization. After 6 months, there was a statistically significant difference for disability (mean difference=3.0 points, 95% confidence interval [CI]=0.6 to 5.4), specific disability (mean difference=-1.1 points, 95% CI=-2.0 to -0.1), and kinesiophobia (mean difference=4.9 points, 95% CI=1.6 to 8.2) in favor of equipment-based Pilates. No differences were found for the remaining outcomes. Equipment-based Pilates was superior to mat Pilates in the 6-month follow-up for the outcomes of disability and kinesiophobia. These benefits were not observed for pain intensity and global perceived effect in patients with chronic nonspecific low back pain.

  20. Optimal Medical Equipment Maintenance Service Proposal Decision Support System combining Activity Based Costing (ABC) and the Analytic Hierarchy Process (AHP).

    Science.gov (United States)

    da Rocha, Leticia; Sloane, Elliot; M Bassani, Jose

    2005-01-01

    This study describes a framework to support the choice of the maintenance service (in-house or third party contract) for each category of medical equipment based on: a) the real medical equipment maintenance management system currently used by the biomedical engineering group of the public health system of the Universidade Estadual de Campinas located in Brazil to control the medical equipment maintenance service, b) the Activity Based Costing (ABC) method, and c) the Analytic Hierarchy Process (AHP) method. Results show the cost and performance related to each type of maintenance service. Decision-makers can use these results to evaluate possible strategies for the categories of equipment.

  1. Análise da dose do laser de baixa potência em equipamentos nacionais Analysis of low-level laser therapy doses in Brazilian equipment

    Directory of Open Access Journals (Sweden)

    TY Fukuda

    2008-02-01

    Full Text Available CONTEXTUALIZAÇÃO: A laserterapia de baixa potência vem sendo cada vez mais utilizada, e o crescente interesse por seus efeitos relaciona-se com a grande quantidade de publicações científicas. Muitos terapeutas e pesquisadores têm-se baseado na definição da dose do laser pela densidade energética (deltaE; porém, a grande variedade de equipamentos de laser pode levar a diferença nos resultados terapêuticos encontrados, por fornecerem parâmetros que variam de acordo com o fabricante. OBJETIVO: Analisar a energia final transmitida ao tecido ao aplicar-se a mesma deltaE em equipamentos de diferentes marcas nacionais. MATERIAIS E MÉTODOS: Foram avaliados sete equipamentos nacionais, com potência média (Pm diferentes, e foram realizadas simulações aplicando deltaE de 1J/cm² em cada aparelho, para avaliar possíveis diferenças na energia final. RESULTADOS: A mesmadeltaE aplicada em diferentes aparelhos nacionais forneceu energia final que variou entre 10 e 90mJ. Esta variação na energia deveu-se principalmente a diferenças na Pm, sendo encontrados valores entre 5,4 e 75mW. CONCLUSÃO: Esta variabilidade na energia final, que é transmitida ao tecido, indica que a deltaE parece não ser o parâmetro que melhor descreve a dose a ser utilizada. É preciso mencionar não só a deltaE, mas também a energia final, para que se possa estabelecer a dose para obtenção do melhor resultado terapêutico.INTRODUCTION: Low-level laser therapy is becoming more popular and there is a growing interest in its effects, as reflected in the increased number of articles published about the subject. Many therapists and researchers have used a laser dose definition based on energy density (deltaE. However, the variety of laser equipments may lead to differences in the therapeutic results found, since the parameters supplied by these equipments vary according to the manufacturer. OBJECTIVE: To analyze the final energy transmitted to the tissue when

  2. Automated and observer based light field indicator edge evaluation in diagnostic X-ray equipment

    Directory of Open Access Journals (Sweden)

    Márcio Bottaro

    Full Text Available Abstract Introduction To analyze edge detection and optical contrast calculation of light field-indicators used in X-ray via automated- and observer-based methods, and comparison with current standard approaches, which do not give exact definition for light field edge determination. Methods Automated light sensor array was used to measure the penumbra zone of the edge in the standard X-ray equipment, while trained and naïve human observers were asked to mark the light field edge according to their own determination. Different interpretations of the contrast were then calculated and compared. Results In contrast to automated measurements of edge definition and detection, measurements by human observers showed large inter-observer variation independent of their training with X-ray equipment. Different contrast calculations considering the different edge definitions gave very different contrast values. Conclusion As the main conclusion, we propose a more exact edge definition of the X-ray light field, corresponding well to the average human observer’s edge determination. The new edge definition method with automated systems would reduce human variability in edge determination. Such errors could potentially affect the approval of X-ray equipment, and also increase the radiation dose. The automated measurement based on human observers’ edge definition and the corresponding contrast calculation may lead to a more precise light field calibration, which enables reduced irradiation doses on radiology patients.

  3. Automated and observer based light field indicator edge evaluation in diagnostic X-ray equipment

    International Nuclear Information System (INIS)

    Bottaro, Marcio; Nagy, Balazs Vince; Soares, Fernanda Cristina Salvador; Rosendo, Danilo Cabral

    2017-01-01

    Introduction: To analyze edge detection and optical contrast calculation of light field-indicators used in X-ray via automated- and observer-based methods, and comparison with current standard approaches, which do not give exact definition for light field edge determination. Methods: Automated light sensor array was used to measure the penumbra zone of the edge in the standard X-ray equipment, while trained and naive human observers were asked to mark the light field edge according to their own determination. Different interpretations of the contrast were then calculated and compared. Results: In contrast to automated measurements of edge definition and detection, measurements by human observers showed large inter-observer variation independent of their training with X-ray equipment. Different contrast calculations considering the different edge definitions gave very different contrast values. Conclusion: As the main conclusion, we propose a more exact edge definition of the X-ray light field, corresponding well to the average human observer's edge determination. The new edge definition method with automated systems would reduce human variability in edge determination. Such errors could potentially affect the approval of X-ray equipment, and also increase the radiation dose. The automated measurement based on human observers’ edge definition and the corresponding contrast calculation may lead to a more precise light field calibration, which enables reduced irradiation doses on radiology patients. (author)

  4. Automated and observer based light field indicator edge evaluation in diagnostic X-ray equipment

    Energy Technology Data Exchange (ETDEWEB)

    Bottaro, Marcio; Nagy, Balazs Vince; Soares, Fernanda Cristina Salvador; Rosendo, Danilo Cabral, E-mail: marcio@iee.usp.br [Universidade de Sao Paulo (USP), SP (Brazil); Optics and Engineering Informatics, Budapest University of Technology and Economics, Budapest (Hungary)

    2017-04-15

    Introduction: To analyze edge detection and optical contrast calculation of light field-indicators used in X-ray via automated- and observer-based methods, and comparison with current standard approaches, which do not give exact definition for light field edge determination. Methods: Automated light sensor array was used to measure the penumbra zone of the edge in the standard X-ray equipment, while trained and naive human observers were asked to mark the light field edge according to their own determination. Different interpretations of the contrast were then calculated and compared. Results: In contrast to automated measurements of edge definition and detection, measurements by human observers showed large inter-observer variation independent of their training with X-ray equipment. Different contrast calculations considering the different edge definitions gave very different contrast values. Conclusion: As the main conclusion, we propose a more exact edge definition of the X-ray light field, corresponding well to the average human observer's edge determination. The new edge definition method with automated systems would reduce human variability in edge determination. Such errors could potentially affect the approval of X-ray equipment, and also increase the radiation dose. The automated measurement based on human observers’ edge definition and the corresponding contrast calculation may lead to a more precise light field calibration, which enables reduced irradiation doses on radiology patients. (author)

  5. Vendor-based laser damage metrology equipment supporting the National Ignition Facility

    International Nuclear Information System (INIS)

    Campbell, J. H; Jennings, R. T.; Kimmons, J. F.; Kozlowski, M. R.; Mouser, R. P.; Schwatz, S.; Stolz, C. J.; Weinzapfel, C. L.

    1998-01-01

    A sizable laser damage metrology effort is required as part of optics production and installation for the 192 beam National Ignition Facility (NIF) laser. The large quantities, high damage thresholds, and large apertures of polished and coated optics necessitates vendor-based metrology equipment to assure component quality during production. This equipment must be optimized to provide the required information as rapidly as possible with limited operator experience. The damage metrology tools include: (1) platinum inclusion damage test systems for laser amplifier slabs, (2) laser conditioning stations for mirrors and polarizers, and (3) mapping and damage testing stations for UV transmissive optics. Each system includes a commercial Nd:YAG laser, a translation stage for the optics, and diagnostics to evaluate damage. The scanning parameters, optical layout, and diagnostics vary with the test fluences required and the damage morphologies expected. This paper describes the technical objectives and milestones involved in fulfilling these metrology requirements

  6. 3D web based learning of medical equipment employed in intensive care units.

    Science.gov (United States)

    Cetin, Aydın

    2012-02-01

    In this paper, both synchronous and asynchronous web based learning of 3D medical equipment models used in hospital intensive care unit have been described over the moodle course management system. 3D medical equipment models were designed with 3ds Max 2008, then converted to ASE format and added interactivity displayed with Viewpoint-Enliven. 3D models embedded in a web page in html format with dynamic interactivity-rotating, panning and zooming by dragging a mouse over images-and descriptive information is embedded to 3D model by using xml format. A pilot test course having 15 h was applied to technicians who is responsible for intensive care unit at Medical Devices Repairing and Maintenance Center (TABOM) of Turkish High Specialized Hospital.

  7. The improvement of maintenance service for traction networks equipment on the base of process approach

    Directory of Open Access Journals (Sweden)

    D. V. Mironov

    2014-12-01

    Full Text Available Purpose. The new methods development for improving the maintenance service for equipment of traction networks in order to increase its efficiency and quality. Methodology. In world practice of solving problems related to the quality of products and services is usually achieved by introducing quality management system in to the enterprises. The provisions of quality management system were used for solving the problem. The technologies of process engineering were used for describing the main stages of maintenance service. Findings. The development of high-speed movement and growth of its intensity, the use of electric rolling stock of a new generation require the introduction of new methods diagnostics of equipment technical state and improvement of the existing maintenance system and repair of power supply. Developing a model of business-processes, their optimization with using techniques of process engineering and system management is needed for the transition to the management system based on the process approach. From the standpoint of the process approach and in accordance with the requirements of the quality management system (ISO 9001-2009, the operation of the E (Department of electrification and power supply infrastructure sector is represented as a scheme of business-processes in which the guaranteed supply with electricity of railway and third-party consumers is defined as the main business-process of management. Each of the sub-process of power supply for consumers is described in details. The use methods and main stages of process approach for sample management system reorganization were investigated. The methodology and the application method of PDCA (Plan-Do-Check-Act closed loop to the equipment maintenance system were described. The monitoring process of traction networks maintenance using the process approach was divided into components after investigations. The technical documentation of maintenance service was investigated in

  8. Strategic project selection based on evidential reasoning approach for high-end equipment manufacturing industry

    Directory of Open Access Journals (Sweden)

    Lu Guangyan

    2017-01-01

    Full Text Available With the rapid development of science and technology, emerging information technologies have significantly changed the daily life of people. In such context, strategic project selection for high-end equipment manufacturing industries faces more and more complexities and uncertainties with the consideration of several complex criteria. For example, a group of experts rather than a single expert should be invited to select strategic project for high-end equipment manufacturing industries and the experts may feel difficulty to express their preferences towards different strategic projects due to their limited cognitive capabilities. In order to handle these complexities and uncertainties, the criteria framework of strategic project selection is firstly constructed based on the characteristics of high-end equipment manufacturing industries and then evidential reasoning (ER approach is introduced in this paper to help experts express their uncertain preferences and aggregate these preferences to generate an appropriate strategic project. A real case of strategic project selection in a high-speed train manufacturing enterprise is investigated to demonstrate the validity of the ER approach in solving strategic project selection problem.

  9. Integrated Instrumentation and Sensor Systems Enabling Condition-Based Maintenance of Aerospace Equipment

    Directory of Open Access Journals (Sweden)

    Richard C. Millar

    2012-01-01

    Full Text Available The objective of the work reported herein was to use a systems engineering approach to guide development of integrated instrumentation/sensor systems (IISS incorporating communications, interconnections, and signal acquisition. These require enhanced suitability and effectiveness for diagnostics and health management of aerospace equipment governed by the principles of Condition-based maintenance (CBM. It is concluded that the systems engineering approach to IISS definition provided clear benefits in identifying overall system requirements and an architectural framework for categorizing and evaluating alternative architectures, relative to a bottom up focus on sensor technology blind to system level user needs. CBM IISS imperatives identified include factors such as tolerance of the bulk of aerospace equipment operational environments, low intrusiveness, rapid reconfiguration, and affordable life cycle costs. The functional features identified include interrogation of the variety of sensor types and interfaces common in aerospace equipment applications over multiplexed communication media with flexibility to allow rapid system reconfiguration to adapt to evolving sensor needs. This implies standardized interfaces at the sensor location (preferably to open standards, reduced wire/connector pin count in harnesses (or their elimination through use of wireless communications.

  10. Oil leakage detection for electric power equipment based on ultraviolet fluorescence effect

    Science.gov (United States)

    Zhang, Jing; Wang, Jian-hui; Xu, Bin; Huang, Zhi-dong; Huang, Lan-tao

    2018-03-01

    This paper presents a method to detect the oil leakage of high voltage power equipment based on ultraviolet fluorescence effect. The method exploits the principle that the insulating oil has the fluorescent effect under the irradiation of specific ultraviolet light. The emission spectrum of insulating oil under excitation light with different wavelengths is measured and analyzed first. On this basis, a portable oil leakage detective device for high voltage power equipment is designed and developed with a selected 365 nm ultraviolet as the excitation light and the low light level camera as the fluorescence image collector. Then, the feasibility of the proposed method and device in different conditions is experimentally verified in the laboratory environment. Finally, the developed oil leakage detective device is applied to 500 kV Xiamen substation and Quanzhou substation. And the results show that the device can detect the oil leakage of high voltage electrical equipment quickly and conveniently even under the condition of a slight oil leakage especially in the low light environment.

  11. Nanoparticle-based therapy for respiratory diseases

    Directory of Open Access Journals (Sweden)

    ADRIANA L. DA SILVA

    2013-03-01

    Full Text Available Nanotechnology is an emerging science with the potential to create new materials and strategies involving manipulation of matter at the nanometer scale (<100 nm. With size-dependent properties, nanoparticles have introduced a new paradigm in pharmacotherapy – the possibility of cell-targeted drug delivery with minimal systemic side effects and toxicity. The present review provides a summary of published findings, especially regarding to nanoparticle formulations for lung diseases. The available data have shown some benefits with nanoparticle-based therapy in the development of the disease and lung remodeling in respiratory diseases. However, there is a wide gap between the concepts of nanomedicine and the published experimental data and clinical reality. In addition, studies are still required to determine the potential of nanotherapy and the systemic toxicity of nanomaterials for future human use.

  12. Predicting response to incretin-based therapy

    Directory of Open Access Journals (Sweden)

    Agrawal N

    2011-04-01

    Full Text Available Sanjay Kalra1, Bharti Kalra2, Rakesh Sahay3, Navneet Agrawal41Department of Endocrinology, 2Department of Diabetology, Bharti Hospital, Karnal, India; 3Department of Endocrinology, Osmania Medical College, Hyderabad, India; 4Department of Medicine, GR Medical College, Gwalior, IndiaAbstract: There are two important incretin hormones, glucose-dependent insulin tropic polypeptide (GIP and glucagon-like peptide-1 (GLP-1. The biological activities of GLP-1 include stimulation of glucose-dependent insulin secretion and insulin biosynthesis, inhibition of glucagon secretion and gastric emptying, and inhibition of food intake. GLP-1 appears to have a number of additional effects in the gastrointestinal tract and central nervous system. Incretin based therapy includes GLP-1 receptor agonists like human GLP-1 analogs (liraglutide and exendin-4 based molecules (exenatide, as well as DPP-4 inhibitors like sitagliptin, vildagliptin and saxagliptin. Most of the published studies showed a significant reduction in HbA1c using these drugs. A critical analysis of reported data shows that the response rate in terms of target achievers of these drugs is average. One of the first actions identified for GLP-1 was the glucose-dependent stimulation of insulin secretion from islet cell lines. Following the detection of GLP-1 receptors on islet beta cells, a large body of evidence has accumulated illustrating that GLP-1 exerts multiple actions on various signaling pathways and gene products in the ß cell. GLP-1 controls glucose homeostasis through well-defined actions on the islet ß cell via stimulation of insulin secretion and preservation and expansion of ß cell mass. In summary, there are several factors determining the response rate to incretin therapy. Currently minimal clinical data is available to make a conclusion. Key factors appear to be duration of diabetes, obesity, presence of autonomic neuropathy, resting energy expenditure, plasma glucagon levels and

  13. Development of processing procedure preparing for digital computer controlled equipment on modular design base

    International Nuclear Information System (INIS)

    Starosel'tsev, O.P.; Khrundin, V.I.

    1982-01-01

    In order to reduce labour consumption of technological preparation of production for digital computer controlled machines during the treatment of steam turbines articles created is a system of modular design of technological processes and controlling programs. A set of typical modulas-transitions, being a number of surfaces of an articles treated with one cutting tool in optimum sequence, and a library of cutting tools are the base of the system. Introduction of such a system sharply enhaneces the efficiency of the equipment utilization [ru

  14. Automated and observer based light field indicator edge evaluation in diagnostic X-ray equipment

    OpenAIRE

    Bottaro, Márcio; Nagy, Balázs Vince; Soares, Fernanda Cristina Salvador; Rosendo, Danilo Cabral

    2017-01-01

    Abstract Introduction To analyze edge detection and optical contrast calculation of light field-indicators used in X-ray via automated- and observer-based methods, and comparison with current standard approaches, which do not give exact definition for light field edge determination. Methods Automated light sensor array was used to measure the penumbra zone of the edge in the standard X-ray equipment, while trained and naïve human observers were asked to mark the light field edge according t...

  15. Life Cycle Management for Equipments in Nuclear Plants Based on Reliability

    International Nuclear Information System (INIS)

    Wang Dalin; Sun Jinlong

    2012-01-01

    Life cycle management model based on reliability includes two parts: obtaining failure rate function and founding cost-oriented model to solve. It is actually a single objective programming whose optimal solution is the most economical replacement period. Parameters of failure rate function are estimated by Weibull process fitting with the method of maximum likelihood. The objective function of the model is life-cost function where the dependent variable is replacement period T, with the constraints of failure rate or availability. After foundation of LCM model, we solve it to find the optimal replacement period for the equipments. (author)

  16. Life cycle management for equipments in nuclear plants based on reliability and actual conditions

    International Nuclear Information System (INIS)

    Dalin, Wang; Jingquan, Liu; Peng, Liu

    2010-01-01

    Life cycle management model based on reliability includes two parts: obtaining failure rate function and founding cost-oriented model to solve. It is actually a single objective programming whose optimal solution is the most economical replacement period. Parameters of failure rate function are estimated by Weibull process fitting with the method of maximum likelihood. The objective function of the model is life-cost function where the dependent variable is replacement period T, with the constraints of failure rate or availability. After foundation of LCM model, we solve it to find the optimal replacement period for the equipments. (authors)

  17. Risk-based equipment removal guide for on-line maintenance at PSE ampersand G

    International Nuclear Information System (INIS)

    Knoll, A.; Smith, C.; Pollock, J.

    1995-01-01

    On-line maintenance plays an important role in achieving safe and reliable power generation in a nuclear power plant. However, maintenance, if not properly planned and performed, may also be an important contributor to plant risk. Therefore, plant-specific procedures are needed for equipment removal from service to enhance the benefits of on-line maintenance and minimize the risks involved. The problem is to identify and implement the most effective on-line maintenance policy in the form of a proceduralized guide to assure plant safety under various operation and maintenance constraints. This paper presents a methodology to develop plant-specific on-line maintenance strategies and acceptance criteria using a multivariate safety approach based on risk assessment. Based on plant-specific data as modeled in the individual plant evaluation (IPE) and the updated probabilistic safety assessment (PSA), the risk-based methodology is currently being applied to the development of proceduralized equipment removal guides at Hope Creek and Salem units 1 and 2 of Public Service Electric and Gas Company (PSE ampersand G)

  18. The Design and Implementation of the Remote Centralized-Monitoring System of Well-Control Equipment Based on RFID Technique

    Directory of Open Access Journals (Sweden)

    Luo Bin

    2017-01-01

    Full Text Available At present, in domestic for the management of well control equipment continue to the traditional way of nameplates identifies and paper-based registration, there are many issues like the separation of data information of device, easy lose, difficult query, confused management and many other problems, which will make the problem device into the well field, and then resulting in well control runaway drilling accident. To solve the above problems, this paper put forward to the integrated remote centralized-monitoring management mode of the well-control equipment. Taking the advantages of IOT technology, adopting the RFID technology, and combining with the remote transmission, this paper designs the remote centralized-monitoring system of well-control equipment based on RFID, which realizes the intelligent management of well-control equipment and meets the actual demand of the well-control equipment safe use and timely scheduling, and it has the ability of field application.

  19. [Resistance to target-based therapy and its circumvention].

    Science.gov (United States)

    Nishio, Kazuto

    2004-07-01

    Intrinsic and acquired resistance to molecular target therapy critically limits the outcome of cancer treatments. Target levels including quantitative and gene alteration should be determinants for the resistance. Downstream of the target molecules, drug metabolism, and drug transport influences the tumor sensitivity to molecular target therapy. The mechanisms of resistance to antibody therapy have not been fully clarified. Correlative clinical studies using these biomarkers of resistance are extremely important for circumvention of clinical resistance to target based therapy.

  20. Evidence-based music therapy practice: an integral understanding.

    Science.gov (United States)

    Abrams, Brian

    2010-01-01

    The American Music Therapy Association has recently put into action a plan called its Research Strategic Priority, with one of its central purposes to advance the music therapy field through research promoting Evidence-Based Practice of music therapy. The extant literature on music therapy practice, theory, and research conveys a range of very different perspectives on what may count as the "evidence" upon which practice is based. There is therefore a need to conceptualize evidence-based music therapy practice in a multifaceted, yet coherent and balanced way. The purpose of this paper is to illustrate a framework based upon four distinct epistemological perspectives on evidence-based music therapy practice that together represent an integral understanding.

  1. Ultrasound-based guidance of intensity-modulated radiation therapy

    International Nuclear Information System (INIS)

    Fung, Albert Y.C.; Ayyangar, Komanduri M.; Djajaputra, David; Nehru, Ramasamy M.; Enke, Charles A.

    2006-01-01

    In ultrasound-guided intensity-modulated radiation therapy (IMRT) of prostate cancer, ultrasound imaging ascertains the anatomical position of patients during x-ray therapy delivery. The ultrasound transducers are made of piezoelectric ceramics. The same crystal is used for both ultrasound production and reception. Three-dimensional (3D) ultrasound devices capture and correlate series of 2-dimensional (2D) B-mode images. The transducers are often arranged in a convex array for focusing. Lower frequency reaches greater depth, but results in low resolution. For clear image, some gel is usually applied between the probe and the skin contact surface. For prostate positioning, axial and sagittal scans are performed, and the volume contours from computed tomography (CT) planning are superimposed on the ultrasound images obtained before radiation delivery at the linear accelerator. The planning volumes are then overlaid on the ultrasound images and adjusted until they match. The computer automatically deduces the offset necessary to move the patient so that the treatment area is in the correct location. The couch is translated as needed. The currently available commercial equipment can attain a positional accuracy of 1-2 mm. Commercial manufacturer designs differ in the detection of probe coordinates relative to the isocenter. Some use a position-sensing robotic arm, while others have infrared light-emitting diodes or pattern-recognition software with charge-couple-device cameras. Commissioning includes testing of image quality and positional accuracy. Ultrasound is mainly used in prostate positioning. Data for 7825 daily fractions of 234 prostate patients indicated average 3D inter-fractional displacement of about 7.8 mm. There was no perceivable trend of shift over time. Scatter plots showed slight prevalence toward superior-posterior directions. Uncertainties of ultrasound guidance included tissue inhomogeneities, speckle noise, probe pressure, and inter

  2. Hot roller embossing system equipped with a temperature margin-based controller

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seyoung, E-mail: seyoungkim@kimm.re.kr; Son, Youngsu; Lee, Sunghee; Ham, Sangyong; Kim, Byungin [Department of Robotics and Mechatronics, Korea Institute of Machinery and Materials (KIMM), Daejeon (Korea, Republic of)

    2014-08-15

    A temperature control system was proposed for hot roller embossing. The roll surface was heated using induction coils and cooled with a circulating chilled water system. The temperature of the roll surface was precisely controlled by a temperature margin-based control algorithm that we developed. Implementation of the control system reduced deviations in the roll surface temperature to less than ±2 °C. The tight temperature control and the ability to rapidly increase and decrease the roll temperature will allow optimum operating parameters to be developed quickly. The temperature margin-based controller could also be used to optimize the time course of electrical power and shorten the cooling time by choosing an appropriate temperature margin, possibly for limited power consumption. The chiller-equipped heating roll with the proposed control algorithm is expected to decrease the time needed to determine the optimal embossing process.

  3. The prediction of the residual life of electromechanical equipment based on the artificial neural network

    Science.gov (United States)

    Zhukovskiy, Yu L.; Korolev, N. A.; Babanova, I. S.; Boikov, A. V.

    2017-10-01

    This article is devoted to the prediction of the residual life based on an estimate of the technical state of the induction motor. The proposed system allows to increase the accuracy and completeness of diagnostics by using an artificial neural network (ANN), and also identify and predict faulty states of an electrical equipment in dynamics. The results of the proposed system for estimation the technical condition are probability technical state diagrams and a quantitative evaluation of the residual life, taking into account electrical, vibrational, indirect parameters and detected defects. Based on the evaluation of the technical condition and the prediction of the residual life, a decision is made to change the control of the operating and maintenance modes of the electric motors.

  4. Hot roller embossing system equipped with a temperature margin-based controller

    International Nuclear Information System (INIS)

    Kim, Seyoung; Son, Youngsu; Lee, Sunghee; Ham, Sangyong; Kim, Byungin

    2014-01-01

    A temperature control system was proposed for hot roller embossing. The roll surface was heated using induction coils and cooled with a circulating chilled water system. The temperature of the roll surface was precisely controlled by a temperature margin-based control algorithm that we developed. Implementation of the control system reduced deviations in the roll surface temperature to less than ±2 °C. The tight temperature control and the ability to rapidly increase and decrease the roll temperature will allow optimum operating parameters to be developed quickly. The temperature margin-based controller could also be used to optimize the time course of electrical power and shorten the cooling time by choosing an appropriate temperature margin, possibly for limited power consumption. The chiller-equipped heating roll with the proposed control algorithm is expected to decrease the time needed to determine the optimal embossing process

  5. Electrical signature analysis to quantify human and animal performance on fitness and therapy equipment such as a treadmill

    Science.gov (United States)

    Cox, Daryl F.; Hochanadel, Charles D.; Haynes, Howard D.

    2010-05-18

    The invention is a human and animal performance data acquisition, analysis, and diagnostic system for fitness and therapy devices having an interface box removably disposed on incoming power wiring to a fitness and therapy device, at least one current transducer removably disposed on said interface box for sensing current signals to said fitness and therapy device, and a means for analyzing, displaying, and reporting said current signals to determine human and animal performance on said device using measurable parameters.

  6. Evaluation of artillery equipment maintenance support capability based on grey clustering

    Science.gov (United States)

    Zhai, Mei-jie; Gao, Peng

    2017-12-01

    This paper, the theory and method of evaluating the capability of equipment maintenance support in China and abroad are studied, from the point of view of the combat task of artillery troops and the strategic attachment in the future military struggle. This paper establishes the framework of the evaluation Index system of the equipment maintenance support capability of the artillery units, and applies the grey clustering method to the evaluation of the equipment maintenance support capability of the artillery units, and finally evaluates the equipment maintenance and support capability of the artillery brigade as an example, and analyzes the evaluation results. This paper finds out the outstanding problems existing in the maintenance and support of military equipment, and puts forward some constructive suggestions, in order to improve the status of military equipment maintenance and support and improve the level of future equipment maintenance.

  7. Cloud-based shaft torque estimation for electric vehicle equipped with integrated motor-transmission system

    Science.gov (United States)

    Zhu, Xiaoyuan; Zhang, Hui; Yang, Bo; Zhang, Guichen

    2018-01-01

    In order to improve oscillation damping control performance as well as gear shift quality of electric vehicle equipped with integrated motor-transmission system, a cloud-based shaft torque estimation scheme is proposed in this paper by using measurable motor and wheel speed signals transmitted by wireless network. It can help reduce computational burden of onboard controllers and also relief network bandwidth requirement of individual vehicle. Considering possible delays during signal wireless transmission, delay-dependent full-order observer design is proposed to estimate the shaft torque in cloud server. With these random delays modeled by using homogenous Markov chain, robust H∞ performance is adopted to minimize the effect of wireless network-induced delays, signal measurement noise as well as system modeling uncertainties on shaft torque estimation error. Observer parameters are derived by solving linear matrix inequalities, and simulation results using acceleration test and tip-in, tip-out test demonstrate the effectiveness of proposed shaft torque observer design.

  8. Pilot-scale equipment development for lithium-based reduction of spent oxide fuel

    International Nuclear Information System (INIS)

    Herrmann, S. D.

    1998-01-01

    An integral function of the electrometallurgical conditioning of DOE spent nuclear fuel is the standardization of waste forms. Argonne National Laboratory (ANL) has developed and is presently demonstrating the electrometallurgical conditioning of sodium-bonded metal fuel from Experimental Breeder Reactor II, resulting in uranium, ceramic waste, and metal waste forms. Engineering studies are underway at ANL in support of pilot-scale equipment development, which would precondition irradiated oxide fuel and likewise demonstrate the application of electrometallurgical conditioning to such non-metallic fuels. This paper highlights the integration of proposed spent oxide fuel conditioning with existing electrometallurgical processes. Additionally, technical bases for engineering activities to support a scale up of an oxide reduction process are described

  9. Fault Detection for Large-Scale Railway Maintenance Equipment Base on Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Junfu Yu

    2014-04-01

    Full Text Available Focusing on the fault detection application for large-scale railway maintenance equipment with the specialties of low-cost, energy efficiency, collecting data of the function units. This paper proposed energy efficiency, convenient installation fault detection application using Sigsbee wireless sensor networks, which Sigsbee is the most widely used protocol based on IEEE 802.15.4. This paper proposed a systematic application from hardware design using STM32F103 chips as processer, to software system. Fault detection application is the basic part of the fault diagnose system, wireless sensor nodes of the fault detection application with different kinds of sensors for verities function units communication by Sigsbee to collecting and sending basic working status data to the home gateway, then data will be sent to the fault diagnose system.

  10. Kinematic and Dynamic Simulation Analysis of Hydraulic Excavator’s Working Equipment based on ADAMS

    Directory of Open Access Journals (Sweden)

    Yu Hong Yan

    2016-01-01

    Full Text Available This paper establishes the 3D excavator model according to the actual size in UG firstly. Then based on the virtual simulation software ADAMS, the virtual prototype of the working device is built by adding interrelated constraints(kinematic pair and hydraulic cylinder driving function and load secondly. This paper gets the main parameters of the excavator working scope and the pressure situation change curves of point of each hydraulic cylinder by making kinematic and dynamic simulation analysis of hydraulic excavator’s working equipment at last. The conclusion providing design theory and improvement for the excavator’s working device, which also play an important role in improving the level of China’s excavator design, enhancing excavator’s performance and promoting the rapid development of excavator industry.

  11. Technical basis for environmental qualification of microprocessor-based safety-related equipment in nuclear power plants

    International Nuclear Information System (INIS)

    Korsah, K.; Wood, R.T.; Hassan, M.; Tanaka, T.J.

    1998-01-01

    This document presents the results of studies sponsored by the Nuclear Regulatory Commission (NRC) to provide the technical basis for environmental qualification of computer-based safety equipment in nuclear power plants. The studies were conducted by Oak Ridge National Laboratory (ORNL), Sandia National Laboratories (SNL), and Brookhaven National Laboratory (BNL). The studies address the following: (1) adequacy of the present test methods for qualification of digital I and C systems; (2) preferred (i.e., Regulatory Guide-endorsed) standards; (3) recommended stressors to be included in the qualification process during type testing; (4) resolution of need for accelerated aging for equipment to be located in a benign environment; and (5) determination of an appropriate approach for addressing the impact of smoke in digital equipment qualification programs. Significant findings from the studies form the technical basis for a recommended approach to the environmental qualification of microprocessor-based safety-related equipment in nuclear power plants

  12. Technical basis for environmental qualification of microprocessor-based safety-related equipment in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Korsah, K.; Wood, R.T. [Oak Ridge National Lab., TN (United States); Hassan, M. [Brookhaven National Lab., Upton, NY (United States); Tanaka, T.J. [Sandia National Labs., Albuquerque, NM (United States)

    1998-01-01

    This document presents the results of studies sponsored by the Nuclear Regulatory Commission (NRC) to provide the technical basis for environmental qualification of computer-based safety equipment in nuclear power plants. The studies were conducted by Oak Ridge National Laboratory (ORNL), Sandia National Laboratories (SNL), and Brookhaven National Laboratory (BNL). The studies address the following: (1) adequacy of the present test methods for qualification of digital I and C systems; (2) preferred (i.e., Regulatory Guide-endorsed) standards; (3) recommended stressors to be included in the qualification process during type testing; (4) resolution of need for accelerated aging for equipment to be located in a benign environment; and (5) determination of an appropriate approach for addressing the impact of smoke in digital equipment qualification programs. Significant findings from the studies form the technical basis for a recommended approach to the environmental qualification of microprocessor-based safety-related equipment in nuclear power plants.

  13. A computer based learning program for radiation therapy

    International Nuclear Information System (INIS)

    Frenzel, T.; Kruell, A.; Schmidt, R.

    1999-01-01

    Many textbooks about radiation therapy for the education of medical, technical and scientific staff are available. But they are restricted to transfer of knowledge via text and figures. On the other hand movies and animated pictures can give you a more realistic impression of the procedures and technical equipment of a radiation therapy department. Therefore, an interactive multimedia teaching program was developed at the Universitaets-Krankenhaus Eppendorf for the department of radiation therapy. The electronic textbook runs under 'MS Windows 3.1 trademark ' (with multimedia extensions) and 'MS Windows 95 trademark ', contains eight chapters and can be used without any preliminary knowledge. The program has been tested by medical personnel, nurses, physicists and physicians and was generally welcome. The program was designed for people with different levels of education to reach as many users as possible. It was not created to replace textbooks but was designed for their supplement. (orig.) [de

  14. Mindfulness-Based Cognitive Therapy for severe Functional Disorders

    DEFF Research Database (Denmark)

    Fjorback, Lone Overby

    MINDFULNESS-BASED COGNITIVE THERAPY FOR FUNCTIONAL DISORDERS- A RANDOMISED CONTROLLED TRIAL   Background: Mindfulness-Based Stress Reduction (MBSR) is a group skills-training program developed by Kabat-Zinn. It is designed to teach patients to become more aware of and relate differently...... to their thoughts, feelings, and bodily sensations. Randomised controlled studies of MBSR have shown mitigation of stress, anxiety, and dysphoria in general population and reduction in total mood disturbance and stress symptoms in a medical population. In Mindfulness Based Cognitive Therapy MBSR is recombined...... with cognitive therapy. Aim: To examine the efficacy of Mindfulness-Based Cognitive Therapy in severe Functional disorders, defined as severe Bodily Distress Disorder. Method: 120 patients are randomised to either Mindfulness Based Cognitive Therapy: a manualized programme with eight weekly 3 ½ hour group...

  15. Mindfulness-Based Cognitive Therapy for severe Functional Disorders

    DEFF Research Database (Denmark)

    Fjorback, Lone Overby

    with cognitive therapy. Aim: To examine the efficacy of Mindfulness-Based Cognitive Therapy in severe Functional disorders, defined as severe Bodily Distress Disorder. Method: 120 patients are randomised to either Mindfulness Based Cognitive Therapy: a manualized programme with eight weekly 3 ½ hour group......MINDFULNESS-BASED COGNITIVE THERAPY FOR FUNCTIONAL DISORDERS- A RANDOMISED CONTROLLED TRIAL   Background: Mindfulness-Based Stress Reduction (MBSR) is a group skills-training program developed by Kabat-Zinn. It is designed to teach patients to become more aware of and relate differently...... to their thoughts, feelings, and bodily sensations. Randomised controlled studies of MBSR have shown mitigation of stress, anxiety, and dysphoria in general population and reduction in total mood disturbance and stress symptoms in a medical population. In Mindfulness Based Cognitive Therapy MBSR is recombined...

  16. Ultraviolet-based therapy for vitiligo: What′s new?

    Directory of Open Access Journals (Sweden)

    Iltefat H Hamzavi

    2012-01-01

    Full Text Available Vitiligo is an ancient disease in which depigmented and hypopigmented macules appear on the skin. It is a disfiguring condition that may lead to severe psychological trauma. Among the many treatment modalities available for use in vitiligo, those using light therapy, and in particular ultraviolet (UV light, are some of the most effective treatments. UV-based therapy includes phototherapy (narrowband UVB, photochemotherapy (psoralens with UVA, and targeted phototherapy (excimer laser and excimer lamp. It is important for any practitioner of UV-based therapy to understand the efficacy of each treatment type, as well as their respective adverse effects. In order to take full advantage of UV-based therapy, location, dosing, and photoadaptation must also be taken into account. This review discusses the various UV-based therapeutic options, adjuvant therapies, optimal dosing guidelines, appropriate patient selection, future treatment options, and recommendations based upon the current evidence and the authors′ experience with vitiligo.

  17. Earth-moving equipment as base machines in forest work. Final report of an NSR project

    Energy Technology Data Exchange (ETDEWEB)

    Johansson, Jerry [ed.

    1997-12-31

    Excavators have been used for forest draining for a long time in the Nordic countries. Only during the 1980s they were introduced as base machines for other forest operations, such as mounding, processing, harvesting, and road construction and road maintenance. Backhoe loaders were introduced in forestry at a somewhat later stage and to a smaller degree. The number of this type of base machines in forestry is so far small and is increasing very slowly. The NSR project `Earth moving equipment as base machines in forest work` started in 1993 and the project ended in 1995. The objective of the project was to obtain an overall picture of this type of machines up to a point where the logs are at landing site, ready for transportation to the industry. The project should cover as many aspects as possible. In order to obtain this picture, the main project was divided into sub projects. The sub projects separately described in this volume are (1) Excavators in ditching operations and site preparation, (2) Backhoe loaders in harvesting operations, (3) Excavators in wood cutting operations, (4) Tracked excavators in forestry operations, (5) Crawler versus wheeled base machines for single-grip harvester, and (6) Soil changes - A comparison between a wheeled and a tracked forest machine

  18. The research of medical equipment on-line detection system based on Android smartphone

    Science.gov (United States)

    Jiang, Junjie; Dong, Xinyu; Zhang, Hongjie; Liu, Mengjun

    2017-06-01

    With the unceasing enhancement of medical level, the expanding scale of medical institutions, medical equipment as an important tool for disease diagnosis, treatment and prevention, used in all levels of medical institutions. The quality and accuracy of the Medical equipment play a key role in the doctor's diagnosis and treatment effect, medical metrology as the important technical foundation is to ensure that the equipment, technology, material components are accurate and the application is safe and reliable. Medical equipment have the feature of variety, large quantity, long using cycle, expensive and multi-site, which bring great difficulty in maintenance, equipment management and verification. Therefore, how to get the medical measurement integrate deeply into the advanced internet technology, information technology and the new measuring method, for real-time monitoring of medical equipment, tracking, positioning, and query is particularly important.

  19. Application of Microprocessor-Based Equipment in Nuclear Power Plants - Technical Basis for a Qualification Methodology

    International Nuclear Information System (INIS)

    Korsah, K.

    2001-01-01

    This document (1) summarizes the most significant findings of the ''Qualification of Advanced Instrumentation and Control (I and C) Systems'' program initiated by the Nuclear Regulatory Commission (NRC); (2) documents a comparative analysis of U.S. and European qualification standards; and (3) provides recommendations for enhancing regulatory guidance for environmental qualification of microprocessor-based safety-related systems. Safety-related I and C system upgrades of present-day nuclear power plants, as well as I and C systems of Advanced Light-Water Reactors (ALWRs), are expected to make increasing use of microprocessor-based technology. The Nuclear Regulatory Commission (NRC) recognized that the use of such technology may pose environmental qualification challenges different from current, analog-based I and C systems. Hence, it initiated the ''Qualification of Advanced Instrumentation and Control Systems'' program. The objectives of this confirmatory research project are to (1) identify any unique environmental-stress-related failure modes posed by digital technologies and their potential impact on the safety systems and (2) develop the technical basis for regulatory guidance using these findings. Previous findings from this study have been documented in several technical reports. This final report in the series documents a comparative analysis of two environmental qualification standards--Institute of Electrical and Electronics Engineers (IEEE) Std 323-1983 and International Electrotechnical Commission (IEC) 60780 (1998)--and provides recommendations for environmental qualification of microprocessor-based systems based on this analysis as well as on the findings documented in the previous reports. The two standards were chosen for this analysis because IEEE 323 is the standard used in the U.S. for the qualification of safety-related equipment in nuclear power plants, and IEC 60780 is its European counterpart. In addition, the IEC document was published in

  20. Effectiveness of mat Pilates or equipment-based Pilates in patients with chronic non-specific low back pain: a protocol of a randomised controlled trial

    Directory of Open Access Journals (Sweden)

    da Luz Maurício Antônio

    2013-01-01

    Full Text Available Abstract Background Chronic low back pain is an expensive and difficult condition to treat. One of the interventions widely used by physiotherapists in the treatment of chronic non-specific low back pain is exercise therapy based upon the Pilates principles. Pilates exercises can be performed with or without specific equipment. These two types of Pilates exercises have never been compared on a high-quality randomised controlled trial. Methods/design This randomised controlled trial with a blinded assessor will evaluate eighty six patients of both genders with chronic low back pain, aged between 18 and 60 years, from one Brazilian private physiotherapy clinic. The patients will be randomly allocated into two groups: Mat Group will perform the exercises on the ground while the Equipment-based Group will perform the Pilates method exercises on the following equipment: Cadillac, Reformer, Ladder Barrel, and Step Chair. The general and specific disability of the patient, kinesiophobia, pain intensity and global perceived effect will be evaluated by a blinded assessor before randomisation and at six weeks and six months after randomisation. In addition, the expectation of the participants and their confidence with the treatment will be evaluated before randomisation and after the first treatment session, respectively. Discussion This will be the first study aiming to compare the effectiveness of Mat and Equipment-based Pilates exercises in patients with chronic non-specific low back pain. The results may help health-care professionals in clinical decision-making and could potentially reduce the treatment costs of this condition. Trial registration Brazilian Registry of Clinical Trials RBR-7tyg5j

  1. Effectiveness of mat Pilates or equipment-based Pilates in patients with chronic non-specific low back pain: a protocol of a randomised controlled trial

    Science.gov (United States)

    2013-01-01

    Background Chronic low back pain is an expensive and difficult condition to treat. One of the interventions widely used by physiotherapists in the treatment of chronic non-specific low back pain is exercise therapy based upon the Pilates principles. Pilates exercises can be performed with or without specific equipment. These two types of Pilates exercises have never been compared on a high-quality randomised controlled trial. Methods/design This randomised controlled trial with a blinded assessor will evaluate eighty six patients of both genders with chronic low back pain, aged between 18 and 60 years, from one Brazilian private physiotherapy clinic. The patients will be randomly allocated into two groups: Mat Group will perform the exercises on the ground while the Equipment-based Group will perform the Pilates method exercises on the following equipment: Cadillac, Reformer, Ladder Barrel, and Step Chair. The general and specific disability of the patient, kinesiophobia, pain intensity and global perceived effect will be evaluated by a blinded assessor before randomisation and at six weeks and six months after randomisation. In addition, the expectation of the participants and their confidence with the treatment will be evaluated before randomisation and after the first treatment session, respectively. Discussion This will be the first study aiming to compare the effectiveness of Mat and Equipment-based Pilates exercises in patients with chronic non-specific low back pain. The results may help health-care professionals in clinical decision-making and could potentially reduce the treatment costs of this condition. Trial registration Brazilian Registry of Clinical Trials RBR-7tyg5j PMID:23298183

  2. Lesson learned - CGID based on the Method 1 and Method 2 for digital equipment

    International Nuclear Information System (INIS)

    Hwang, Wonil; Sohn, Kwang Young; Cho, Chang Hwan; Kim, Sung Jong

    2015-01-01

    The acceptance methods associated with commercial-grade dedication are the following: 1) Special tests and inspection (Method 1) 2) Commercial-grade surveys (Method 2) 3) Source verification (Method 3) 4) An acceptable item and supplier performance record (Method 4) Special tests and inspections, often referred to as Method 1, are performed by the dedicating entity after the item is received to verify selected critical characteristics. Conducting a commercial-grade survey of a supplier is often referred to as Method 2. Supplier audits to verify compliance with a nuclear QA program do not meet the intent of a commercial-grade survey. Source verification, often referred to as Method 3, entails verification of critical characteristics during manufacture and testing of the item being procured. The performance history (good or bad) of the item and supplier is a consideration when determining the use of the other acceptance methods and the rigor with which they are used on a case-by-case basis. Some digital equipment system has the delivery reference and its operating history for Nuclear Power Plant as far as surveyed. However it was found that there is difficulty in collecting this of supporting data sheet, so that supplier usually decide to conduct the CGID based on the Method-1 and Method-2 based on the initial qualification likely. It is conceived that the Method-4 might be a better approach for CGID(Commercial Grade Item Dedication) even if there are some difficulties in data package for justifying CGID from the vendor and operating organization. This paper present the lesson learned from the consulting for Method-1 and 2 for digital equipment dedication. Considering all the information above, there are a couple of issues to remind in order to perform the CGID for Method-2. In doing commercial grade survey based on Method 2, quality personnel as well as technical engineer shall be involved for integral dedication. Other than this, the review of critical

  3. The development of special equipment amplitude detection instrument based on DSP

    International Nuclear Information System (INIS)

    Dai Sidan; Chen Ligang; Lan Peng; Wang Huiting; Zhang Liangxu; Wang Lin

    2014-01-01

    Development and industrial application of special equipment plays an important role in the development of nuclear energy process. Equipment development process need to do a lot of tests, amplitude detection is a key test,it can analysis the device's electromechanical and physical properties. In the industrial application, the amplitude detection can effectively reflect the operational status of the current equipment, the equipment can also be a certain degree of fault diagnosis, identify problems in a timely manner. The main development target in this article is amplitude detection of special equipment. This article describes the development of special equipment amplitude detection instrument. The instrument uses a digital signal processor (DSP) as the central processing unit, and uses the DSP + CPLD + high-speed AD technology to build a complete set of high-precision signal acquisition and analysis processing systems, rechargeable lithium battery as the powered device. It can do a online monitoring of special equipment amplitude, speed parameters by acquiring and analysing the tachometer signal in the special equipment, and locally display through the LCD screen. (authors)

  4. Performance characterization of night vision equipment based on Triangle Orientation Discrimination (TOD) methodology

    NARCIS (Netherlands)

    Laurent, N.; Lejard, C.; Deltel, G.; Bijl, P.

    2013-01-01

    Night vision equipment is crucial in order to accomplish supremacy and safety of the troops on the battlefield. Evidently, system integrators, MODs and end-users need access to reliable quantitative characterization of the expected field performance when using night vision equipment. The Image

  5. Allocation of R&D Equipment Expenditure Based on Organisation Discipline Profiles

    Science.gov (United States)

    Wells, Xanthe E.; Foster, Nigel; Finch, Adam; Elsum, Ian

    2017-01-01

    Sufficient and state-of-the-art research equipment is one component required to maintain the research competitiveness of a R&D organisation. This paper describes an approach to inform more optimal allocation of equipment expenditure levels in a large and diverse R&D organisation, such as CSIRO. CSIRO is Australia's national science agency,…

  6. Nanobody-based cancer therapy of solid tumors

    NARCIS (Netherlands)

    Kijanka, Marta|info:eu-repo/dai/nl/328212792; Dorresteijn, Bram|info:eu-repo/dai/nl/31401635X; Oliveira, Sabrina; van Bergen en Henegouwen, Paul M P|info:eu-repo/dai/nl/071919481

    The development of tumor-targeted therapies using monoclonal antibodies has been successful during the last 30 years. Nevertheless, the efficacy of antibody-based therapy is still limited and further improvements are eagerly awaited. One of the promising novel developments that may overcome the

  7. Cell-based therapies for chronic kidney disease

    NARCIS (Netherlands)

    van Koppen, A.N.

    2013-01-01

    Chronic kidney disease (CKD) may lead to end-stage renal failure, requiring renal replacement strategies. Development of new therapies to reduce progression of CKD is therefore a major global public health target. The aim of this thesis was to investigate whether cell-based therapies have the

  8. Questionnaire-based evaluation of mobile phone interference with medical-electrical equipment in Swedish hospitals.

    Science.gov (United States)

    Wiinberg, Stig; Samuelsson, Göran; Larsson, Stefan; Nilsson, Barbro; Jönsson, Patrik X; Ivarsson, Bodil; Olofsson, Per-Åke

    2017-08-09

    National recommendations in Sweden recommend a safety distance of 3 meter (m) between mobile phones and medical-electrical (ME) equipment in hospitals. A questionnaire was used to investigate how often mobile phones were reported to interfere with ME products in clinical practice across Sweden. The results confirmed that ME equipment can be affected by mobile phone use but, the risk of the patient's outcome being affected were minimal; no cases were identified which led to injury or death. In conclusion, the results support recommendations for a general safety distance of 0.5 m between mobile phones and ME equipment in care environments.

  9. Combined prediction model for supply risk in nuclear power equipment manufacturing industry based on support vector machine and decision tree

    International Nuclear Information System (INIS)

    Shi Chunsheng; Meng Dapeng

    2011-01-01

    The prediction index for supply risk is developed based on the factor identifying of nuclear equipment manufacturing industry. The supply risk prediction model is established with the method of support vector machine and decision tree, based on the investigation on 3 important nuclear power equipment manufacturing enterprises and 60 suppliers. Final case study demonstrates that the combination model is better than the single prediction model, and demonstrates the feasibility and reliability of this model, which provides a method to evaluate the suppliers and measure the supply risk. (authors)

  10. The critical role of community-based micro-grants for disability aids and equipment: results from a needs analysis.

    Science.gov (United States)

    Muenchberger, Heidi; Ehrlich, Carolyn; Parekh, Sanjoti; Crozier, Michelle

    2016-01-01

    To investigate the role of philanthropic micro-grants (maximum of $10,000) in the provision of aids and equipment for adults (aged 18-65 years of age) with complex disabilities and examine key trends in aids and equipment requests. This study examined, through quantitative and qualitative analysis, aids and equipment requests (n = 371 individual applications as represented by 136 service organisations in three Australian states) received by a not-for-profit (NFP) organisation across five consecutive years of an innovative micro-grants scheme. Findings highlight that living situation (living with family or living independently) significantly influences the nature of requests for respite, aids, equipment and home modifications. Specifically, people with complex disabilities living with their families require greater combined service provision (higher equipment need, respite support, home modifications) than those living independently (equipment need only). Type of disability did not influence request type. Qualitative data further indicated the "last resort" nature of respite requests, particularly for younger applicants (under 45 years of age) indicating critical unmet needs in the community. Results demonstrate the vital role of NFP organisations and philanthropic funds in supporting daily lifestyle aids and equipment (including respite) that might otherwise not be funded for people with complex disabilities. Although preliminary in its scope and prior to implementation of a National Disability Insurance Scheme (NDIS) in Australia, findings suggest both opportunity and risk to the uptake of community-based micro-grant funding: opportunity for users through the provision of essential aids and lifestyle supports, and risk through over-subscription and devolving of responsibility for critical support resources from public sector. The aids and equipment needs of adults under the age of 65 appear to have been underestimated, poorly defined and under

  11. Fault Diagnosis Method of Polymerization Kettle Equipment Based on Rough Sets and BP Neural Network

    Directory of Open Access Journals (Sweden)

    Shu-zhi Gao

    2013-01-01

    Full Text Available Polyvinyl chloride (PVC polymerizing production process is a typical complex controlled object, with complexity features, such as nonlinear, multivariable, strong coupling, and large time-delay. Aiming at the real-time fault diagnosis and optimized monitoring requirements of the large-scale key polymerization equipment of PVC production process, a real-time fault diagnosis strategy is proposed based on rough sets theory with the improved discernibility matrix and BP neural networks. The improved discernibility matrix is adopted to reduct the attributes of rough sets in order to decrease the input dimensionality of fault characteristics effectively. Levenberg-Marquardt BP neural network is trained to diagnose the polymerize faults according to the reducted decision table, which realizes the nonlinear mapping from fault symptom set to polymerize fault set. Simulation experiments are carried out combining with the industry history datum to show the effectiveness of the proposed rough set neural networks fault diagnosis method. The proposed strategy greatly increased the accuracy rate and efficiency of the polymerization fault diagnosis system.

  12. [Acceptance and mindfulness-based cognitive-behavioral therapies].

    Science.gov (United States)

    Ngô, Thanh-Lan

    2013-01-01

    Cognitive behavioral therapy (CBT) is one of the main approaches in psychotherapy. It teaches the patient to examine the link between dysfunctional thoughts and maladaptive behaviors and to re- evaluate the cognitive biases involved in the maintenance of symptoms by using strategies such as guided discovery. CBT is constantly evolving in part to improve its' effectiveness and accessibility. Thus in the last decade, increasingly popular approaches based on mindfulness and acceptance have emerged. These therapies do not attempt to modify cognitions even when they are biased and dysfunctional but rather seek a change in the relationship between the individual and the symptoms. This article aims to present the historical context that has allowed the emergence of this trend, the points of convergence and divergence with traditional CBT as well as a brief presentation of the different therapies based on mindfulness meditation and acceptance. Hayes (2004) described three successive waves in behavior therapy, each characterized by "dominant assumptions, methods and goals": traditional behavior therapy, cognitive therapy and therapies based on mindfulness meditation and acceptance. The latter consider that human suffering occurs when the individual lives a restricted life in order avoid pain and immediate discomfort to the detriment of his global wellbeing. These therapies combine mindfulness, experiential, acceptance strategies with traditional behavior principles in order to attain lasting results. There are significant points of convergence between traditional CBT and therapies based on mindfulness meditation and acceptance. They are both empirically validated, based upon a theoretical model postulating that avoidance is key in the maintenance of psychopathology and they recommend an approach strategy in order to overcome the identified problem. They both use behavioral techniques in the context of a collaborative relationship in order to identify precise problems and to

  13. Improving the efficiency of thermal power equipment based on technologies using surfactants

    Science.gov (United States)

    Nikolaeva, L. A.; Zueva, O. S.

    2015-10-01

    The formation of deposits on the functional surfaces of the equipment of heating systems and their corrosion are one of the major energetic problems. To improve the operational efficiency of thermal power equipment, surface-active agents (surfactants) are widely used, which are applied for the treatment of the working surfaces before use, during use, to prevent the parking corrosion, as well as while performing periodic chemical cleanings of power equipment. The tests have been performed, and the technology of application of Auge Neo Ac 56 acid product (MAHIM, Kazan) has been developed, designed to remove mineral deposits and scale from cooling and boiler systems without mechanical influence on them and without disassembly of technological equipment.

  14. Home-based Constraint Induced Movement Therapy Poststroke

    OpenAIRE

    Stephen Isbel HScD; Christine Chapparo PhD; David McConnell PhD; Judy Ranka PhD

    2014-01-01

    Background: This study examined the efficacy of a home-based Constraint Induced Movement Therapy (CI Therapy) protocol with eight poststroke survivors. Method: Eight ABA, single case experiments were conducted in the homes of poststroke survivors. The intervention comprised restraint of the intact upper limb in a mitt for 21 days combined with a home-based and self-directed daily activity regime. Motor changes were measured using The Wolf Motor Function Test (WMFT) and the Motor Activity L...

  15. A computer based approach for Material, Manpower and Equipment managementin the Construction Projects

    Science.gov (United States)

    Sasidhar, Jaladanki; Muthu, D.; Venkatasubramanian, C.; Ramakrishnan, K.

    2017-07-01

    The success of any construction project will depend on efficient management of resources in a perfect manner to complete the project with a reasonable budget and time and the quality cannot be compromised. The efficient and timely procurement of material, deployment of adequate labor at correct time and mobilization of machinery lacking in time, all of them causes delay, lack of quality and finally affect the project cost. It is known factor that Project cost can be controlled by taking corrective actions on mobilization of resources at a right time. This research focuses on integration of management systems with the computer to generate the model which uses OOM data structure which decides to include automatic commodity code generation, automatic takeoff execution, intelligent purchase order generation, and components of design and schedule integration to overcome the problems of stock out. To overcome the problem in equipment management system inventory management module is suggested and the data set of equipment registration number, equipment number, description, date of purchase, manufacturer, equipment price, market value, life of equipment, production data of the equipment which includes equipment number, date, name of the job, hourly rate, insurance, depreciation cost of the equipment, taxes, storage cost, interest, oil, grease, and fuel consumption, etc. is analyzed and the decision support systems to overcome the problem arising out improper management is generated. The problem on labor is managed using scheduling, Strategic management of human resources. From the generated support systems tool, the resources are mobilized at a right time and help the project manager to finish project in time and thereby save the abnormal project cost and also provides the percentage that can be improved and also research focuses on determining the percentage of delays that are caused by lack of management of materials, manpower and machinery in different types of projects

  16. Design of data acquisition system ZOH production process equipment of ZBS (zircon based sulfate)

    International Nuclear Information System (INIS)

    Moch Rosyid; Tunjung Indrati Y

    2013-01-01

    Design of data acquisition system of ZOH maker unit from ZBS has performed. Design is done as a follow-up of The Design Flow stirred tank reactor (RATB) ZOH Making of ZBS is equipped with a data acquisition system. The design of the system is going to work based on constants or parameters that have been previously calculated. Design method begins with understanding the process description of ZBS ZOH continuous basis, identify the parameters to be observed. Description of the process need to know to determine the actuator is used, as for these parameters are used to determine the sensor to be used. The parameter are the detection of NH 4 OH and ZBS reserves the feeder tank, flow rate ZBS and NH 4 OH, the temperature inside RATB, RATB and pH , the produced flow rate of ZOH. Based on the calculation, in order to get the results needed ZOH ZBS will flow into the reactor at the rate of 10 ml/min simultaneously with NH 4 OH with discharge flow 6.1 ml/min into the RATB 3 liters volume. When the volume reaches half tank RATB then start heating is turned on while the constant feed flow. Conditions of pH and temperature on the RATB always monitored by setting point pH at 10 while setting point temperature of 90°C. Monitoring parameters require gauge/transducer or a particular sensor. The study on the obtained results in the form of a flow chart design controller when controlling the process, when read and transmit data, and display the resulting data acquisition process parameters on the screen according to the parameters that was planned. (author)

  17. Therapy Decision Support Based on Recommender System Methods.

    Science.gov (United States)

    Gräßer, Felix; Beckert, Stefanie; Küster, Denise; Schmitt, Jochen; Abraham, Susanne; Malberg, Hagen; Zaunseder, Sebastian

    2017-01-01

    We present a system for data-driven therapy decision support based on techniques from the field of recommender systems. Two methods for therapy recommendation, namely, Collaborative Recommender and Demographic-based Recommender , are proposed. Both algorithms aim to predict the individual response to different therapy options using diverse patient data and recommend the therapy which is assumed to provide the best outcome for a specific patient and time, that is, consultation. The proposed methods are evaluated using a clinical database incorporating patients suffering from the autoimmune skin disease psoriasis. The Collaborative Recommender proves to generate both better outcome predictions and recommendation quality. However, due to sparsity in the data, this approach cannot provide recommendations for the entire database. In contrast, the Demographic-based Recommender performs worse on average but covers more consultations. Consequently, both methods profit from a combination into an overall recommender system.

  18. Therapy Decision Support Based on Recommender System Methods

    Directory of Open Access Journals (Sweden)

    Felix Gräßer

    2017-01-01

    Full Text Available We present a system for data-driven therapy decision support based on techniques from the field of recommender systems. Two methods for therapy recommendation, namely, Collaborative Recommender and Demographic-based Recommender, are proposed. Both algorithms aim to predict the individual response to different therapy options using diverse patient data and recommend the therapy which is assumed to provide the best outcome for a specific patient and time, that is, consultation. The proposed methods are evaluated using a clinical database incorporating patients suffering from the autoimmune skin disease psoriasis. The Collaborative Recommender proves to generate both better outcome predictions and recommendation quality. However, due to sparsity in the data, this approach cannot provide recommendations for the entire database. In contrast, the Demographic-based Recommender performs worse on average but covers more consultations. Consequently, both methods profit from a combination into an overall recommender system.

  19. [Hydrotherapy equipment].

    Science.gov (United States)

    Tsibikov, V B; Ragozin, S I; Mikheeva, L V

    1985-01-01

    A flow-chart is developed demonstrating the relation between medical and prophylactic institutions within the organizational structure of the rehabilitation system and main types of rehabilitation procedures. In order to ascertain the priority in equipping rehabilitation services with adequate hardware the special priority criterion is introduced. The highest priority is assigned to balneotherapeutic and fangotherapeutic services. Based on the operation-by-operation analysis of clinical processes related to service and performance of balneologic procedures the preliminary set of clinical devices designed for baths, basins and showers in hospitals and rehabilitation departments is defined in a generalized form.

  20. Moving from Virtual Reality Exposure-Based Therapy to Augmented Reality Exposure-Based Therapy: A Review

    OpenAIRE

    Baus, Oliver; Bouchard, Stéphane

    2014-01-01

    This paper reviews the move from virtual reality exposure-based therapy to augmented reality exposure-based therapy (ARET). Unlike virtual reality (VR), which entails a complete virtual environment (VE), augmented reality (AR) limits itself to producing certain virtual elements to then merge them into the view of the physical world. Although, the general public may only have become aware of AR in the last few years, AR type applications have been around since beginning of the twentieth centur...

  1. The European hadron therapy community touches base

    CERN Multimedia

    Audrey Ballantine, Manuela Cirilli, Evangelia Dimovasili, Manjit Dosanjh, Seamus Hegarty

    2010-01-01

    The European hadron therapy community gathered in Stockholm from 3 to 5 September for the annual ENLIGHT workshops. Three of the four EC-funded projects born under the umbrella of ENLIGHT (see box) were discussed in the prestigious Nobel Forum at the Karolinska Institutet.   Souvenir photo from the ENLIGHT workshops On its second birthday, the PARTNER Initial Training Network was especially under the spotlight, as the European Commission conducted a formal project review bringing together the institutes, companies and young researchers involved. The 21 PARTNER researchers experienced the thrill of presenting their work in this privileged setting. During the coffee breaks, they joked about this being their only chance in life to speak in the Nobel Forum – but who knows what these brilliant young minds will achieve! They certainly impressed the European Commission’s Project Officer Gianluca Coluccio and Expert Reviewer Kaisa Hellevuo, who stated that PARTNER is a showcase proj...

  2. Qualification of Programmable Electronic System (PES) equipment based on international nuclear I and C standards

    International Nuclear Information System (INIS)

    De Grosbois, J.; Hepburn, G. A.; Olmstead, R.; Goble, W.; Kumar, V.

    2006-01-01

    Nuclear power plants (NPPs) are increasingly faced with the challenge of qualifying procured equipment, sub-components, and systems that contain digital programmed electronics for use in safety-related applications. Referred to as a 'programmable electronic system' (PES), such equipment typically contains both complex logic that is vulnerable to systematic design faults, and low voltage electronics hardware that is subject to random faults. Procured PES products or components are often only commercial grade, yet can offer reliable cost effective alternatives to custom-designed or nuclear qualified equipment, provided they can be shown to meet the quality assurance, functional safety, environmental, and reliability requirements of a particular application. The process of confirming this is referred to as application-specific product qualification (ASPQ) and can be challenging and costly. This paper provides an overview of an approach that has been developed at Atomic Energy Canada Limited (AECL) and successfully applied to PES equipment intended for use in domestic Candu R 6 nuclear power plants and special purpose reactors at Chalk River Laboratories. The approach has evolved over the past decade and has recently been adapted to be consistent with, and take advantage of new standards that are applicable to nuclear safety-related I and C systems. Also discussed are how recognized third-party safety-certifications of PES equipment to International Electrotechnical Commission (IEC) standards, and the assessment methods employed, may be used to reduce ASPQ effort. (authors)

  3. Handling equipment Selection in open pit mines by using an integrated model based on group decision making

    Directory of Open Access Journals (Sweden)

    Abdolreza Yazdani-Chamzini

    2012-10-01

    Full Text Available Process of handling equipment selection is one of the most important and basic parts in the project planning, particularly mining projects due to holding a high charge of the total project's cost. Different criteria impact on the handling equipment selection, while these criteria often are in conflicting with each other. Therefore, the process of handling equipment selection is a complex and multi criteria decision making problem. There are a variety of methods for selecting the most appropriate equipment among a set of alternatives. Likewise, according to the sophisticated structure of the problem, imprecise data, less of information, and inherent uncertainty, the usage of the fuzzy sets can be useful. In this study a new integrated model based on fuzzy analytic hierarchy process (FAHP and fuzzy technique for order preference by similarity to ideal solution (FTOPSIS is proposed, which uses group decision making to reduce individual errors. In order to calculate the weights of the evaluation criteria, FAHP is utilized in the process of handling equipment selection, and then these weights are inserted to the FTOPSIS computations to select the most appropriate handling system among a pool of alternatives. The results of this study demonstrate the potential application and effectiveness of the proposed model, which can be applied to different types of sophisticated problems in real problems.

  4. Italy-Japan international project-based learning for developing human resources using design of welfare equipment as a subject.

    Science.gov (United States)

    Hanafusa, A; Komeda, T; Ito, K; Zobel, P Beomonte

    2015-08-01

    Project-based learning (PBL) is effective for developing human resources of young students. The design of welfare equipment, such as wheelchairs and gait assistive devices, is taken as the subject in this study because these devices must be fit to their environment, users, and method of use; students must consider the circumstances of each country concerned. The program commenced in 2012 at L'Aquila, Italy, and the Shibaura Institute of Technology, Japan and has been continuing for three years. Students were divided into four groups and discussions were held on how to adapt the equipment to the user and environment. After discussion, they designed and simulated a model of the equipment using CAD. Finally, they presented their designs to each other. Through the program, students had fruitful discussions, exchanged ideas from different cultures, and learned from each other. Furthermore, friendships among the students were nurtured. It is believed that the objective of the program was satisfactorily accomplished.

  5. Maintenance-based prognostics of nuclear plant equipment for long-term operation

    Energy Technology Data Exchange (ETDEWEB)

    Welz, Zachary; Coble, Jamie; Upadhyaya, Belle; Hines, Wes [University of Tennessee, Knoxville (United States)

    2017-08-15

    While industry understands the importance of keeping equipment operational and well maintained, the importance of tracking maintenance information in reliability models is often overlooked. Prognostic models can be used to predict the failure times of critical equipment, but more often than not, these models assume that all maintenance actions are the same or do not consider maintenance at all. This study investigates the influence of integrating maintenance information on prognostic model prediction accuracy. By incorporating maintenance information to develop maintenance-dependent prognostic models, prediction accuracy was improved by more than 40% compared with traditional maintenance-independent models. This study acts as a proof of concept, showing the importance of utilizing maintenance information in modern prognostics for industrial equipment.

  6. Fault diagnosis of nuclear-powered equipment based on HMM and SVM

    International Nuclear Information System (INIS)

    Yue Xia; Zhang Chunliang; Zhu Houyao; Quan Yanming

    2012-01-01

    For the complexity and the small fault samples of nuclear-powered equipment, a hybrid HMM/SVM method was introduced in fault diagnosis. The hybrid method has two steps: first, HMM is utilized for primary diagnosis, in which the range of possible failure is reduced and the state trends can be observed; then faults can be recognized taking the advantage of the generalization ability of SVM. Experiments on the main pump failure simulator show that the HMM/SVM system has a high recognition rate and can be used in the fault diagnosis of nuclear-powered equipment. (authors)

  7. Evidence-based approach to the maintenance of laboratory and medical equipment in resource-poor settings.

    Science.gov (United States)

    Malkin, Robert; Keane, Allison

    2010-07-01

    Much of the laboratory and medical equipment in resource-poor settings is out-of-service. The most commonly cited reasons are (1) a lack of spare parts and (2) a lack of highly trained technicians. However, there is little data to support these hypotheses, or to generate evidence-based solutions to the problem. We studied 2,849 equipment-repair requests (of which 2,529 were out-of-service medical equipment) from 60 resource-poor hospitals located in 11 nations in Africa, Europe, Asia, and Central America. Each piece of equipment was analyzed by an engineer or an engineering student and a repair was attempted using only locally available materials. If the piece was placed back into service, we assumed that the engineer's problem analysis was correct. A total of 1,821 pieces of medical equipment were placed back into service, or 72%, without requiring the use of imported spare parts. Of those pieces repaired, 1,704 were sufficiently documented to determine what knowledge was required to place the equipment back into service. We found that six domains of knowledge were required to accomplish 99% of the repairs: electrical (18%), mechanical (18%), power supply (14%), plumbing (19%), motors (5%), and installation or user training (25%). A further analysis of the domains shows that 66% of the out-of-service equipment was placed back into service using only 107 skills covering basic knowledge in each domain; far less knowledge than that required of a biomedical engineer or biomedical engineering technician. We conclude that a great majority of laboratory and medical equipment can be put back into service without importing spare parts and using only basic knowledge. Capacity building in resource-poor settings should first focus on a limited set of knowledge; a body of knowledge that we call the biomedical technician's assistant (BTA). This data set suggests that a supported BTA could place 66% of the out-of-service laboratory and medical equipment in their hospital back

  8. Key outcomes from risk based assessment of pressure equipment in refineries

    International Nuclear Information System (INIS)

    Firth, D.; Lichti, K.; Hill, T.; Thomas, C.; Widrig, J.; Simmonds, G.; Karstensen, A.

    2012-01-01

    Risk based assessment (RBA) has become the best industry practice for management of pressure equipment reliability. Application of RBA programs significantly reduces risk and gives opportunity to optimize inspection programs and produce long term financial benefits. Quest Integrity Group have implemented risk based inspection programs n a variety of industries including ammonia, methanol, geothermal power, :combined cycle power, gas turbines, gas production facilities and refineries. This paper outlines the semi quantitative RBA procedures that have been followed and lists some of the specific technical outcomes. Advanced inspection and life assessment methods used in support of RBI in refineries ire discussed. Piping in refineries is a key risk issue and it is not uncommon for piping failures to result in major incidents. Specific inspection programs are available to monitor differing damage processes such as flow assisted corrosion, hydrogen damage and corrosion under insulation. During assessment it s often found that numerous pipes have never been inspected especially underground smaller diameter pipes which are frequently considered to be un-piggable using conventional technologies and difficult to inspect. Advanced high accuracy flexible miniaturized ultrasonic intelligent pigging combined with fitness for service assessment such as Invista TM is recommended for inspection of critical pipelines which previously have been un-piggable. The processing of crude oil from a range of sources can result in significant variations in the levels of contaminants such as chlorides and sulfides. Major failures have occurred as a result of very rapid increases in corrosion rates in hydrotreating processes due to rapid changes in chemistry. The outcome of the assessment of plants that have potentially high and variable levels of contaminants often results in a review the process chemistry, how it is monitored and development of a detailed corrosion monitoring program. Fired

  9. Antibody-Based Therapies in Multiple Myeloma

    Directory of Open Access Journals (Sweden)

    Yu-Tzu Tai

    2011-01-01

    Full Text Available The unmet need for improved multiple myeloma (MM therapy has stimulated clinical development of monoclonal antibodies (mAbs targeting either MM cells or cells of the bone marrow (BM microenvironment. In contrast to small-molecule inhibitors, therapeutic mAbs present the potential to specifically target tumor cells and directly induce an immune response to lyse tumor cells. Unique immune-effector mechanisms are only triggered by therapeutic mAbs but not by small molecule targeting agents. Although therapeutic murine mAbs or chimeric mAbs can cause immunogenicity, the advancement of genetic recombination for humanizing rodent mAbs has allowed large-scale production and designation of mAbs with better affinities, efficient selection, decreasing immunogenicity, and improved effector functions. These advancements of antibody engineering technologies have largely overcome the critical obstacle of antibody immunogenicity and enabled the development and subsequent Food and Drug Administration (FDA approval of therapeutic Abs for cancer and other diseases.

  10. Validation of GPU based TomoTherapy dose calculation engine.

    Science.gov (United States)

    Chen, Quan; Lu, Weiguo; Chen, Yu; Chen, Mingli; Henderson, Douglas; Sterpin, Edmond

    2012-04-01

    The graphic processing unit (GPU) based TomoTherapy convolution/superposition(C/S) dose engine (GPU dose engine) achieves a dramatic performance improvement over the traditional CPU-cluster based TomoTherapy dose engine (CPU dose engine). Besides the architecture difference between the GPU and CPU, there are several algorithm changes from the CPU dose engine to the GPU dose engine. These changes made the GPU dose slightly different from the CPU-cluster dose. In order for the commercial release of the GPU dose engine, its accuracy has to be validated. Thirty eight TomoTherapy phantom plans and 19 patient plans were calculated with both dose engines to evaluate the equivalency between the two dose engines. Gamma indices (Γ) were used for the equivalency evaluation. The GPU dose was further verified with the absolute point dose measurement with ion chamber and film measurements for phantom plans. Monte Carlo calculation was used as a reference for both dose engines in the accuracy evaluation in heterogeneous phantom and actual patients. The GPU dose engine showed excellent agreement with the current CPU dose engine. The majority of cases had over 99.99% of voxels with Γ(1%, 1 mm) engine also showed similar degree of accuracy in heterogeneous media as the current TomoTherapy dose engine. It is verified and validated that the ultrafast TomoTherapy GPU dose engine can safely replace the existing TomoTherapy cluster based dose engine without degradation in dose accuracy.

  11. A typewriting system operated by head movements, based on home-computer equipment

    NARCIS (Netherlands)

    Heuvelmans, A.M.F.; Mélotte, H.E.M.; Neve, J.J.

    1990-01-01

    For persons who cannot move their hands and legs we have designed a relatively inexpensive typewriting system which can be operated by movements of the head. The typewriter is made up of commercially available home computer equipment - i e, a computer including monitor and printer and a headset

  12. Commercial Best Practices in Contracting for Knowledge-Based and Equipment-Related Services

    Science.gov (United States)

    2015-08-01

    January 12, 2015, http://news.thomasnet.com/imt /2014/09/04/why-accenture-thinks-it-can- rattle-ibm-in-plm. 33 Sean Broderick , “North American Re...Services-Using-Predictive-Analytics-to-Increase-Equipment-Reliability-and- Reduce-Costs.pdf. Aviation Week Intelligence Network. Sean Broderick . “North

  13. Tolerance-based Structural Design of Tubular-Structure Loading Equipments

    Directory of Open Access Journals (Sweden)

    Jiping Lu

    2011-05-01

    is worked out under different ball screws, trapezoidal screw threads, worm and worm gears. To meet the requirement of tolerance in tubular-structure assembly, mechanisms for all motions are defined. The design of loading equipment is tested and assessed by experiments, and the result shows the design is highly qualified for its assembly.

  14. Mindfulness-based cognitive therapy for multiple chemical sensitivity

    DEFF Research Database (Denmark)

    Hauge, Christian R; Bonde, Jens Peter E; Rasmussen, Alice

    2012-01-01

    no evidence-based treatments for MCS. Nevertheless, there is a substantial need for a treatment, because the condition can be severely disabling and can greatly reduce the quality of life (QOL) for those affected.In this study, we aim to assess the effects of a mindfulness-based cognitive therapy (MBCT...

  15. An upconversion nanoparticle - Zinc phthalocyanine based nanophotosensitizer for photodynamic therapy

    NARCIS (Netherlands)

    Xia, L.; Kong, X.; Liu, X.; Tu, L.; Zhang, Y.; Chang, Y.; Liu, K.; Shen, D.; Zhao, H.; Zhang, H.

    2014-01-01

    Recent advances in NIR triggering upconversion-based photodynamic therapy have led to substantial improvements in upconversion-based nanophotosensitizers. How to obtain the high efficiency of singlet oxygen generation under low 980 nm radiation dosage still remains a challenge. A highly efficient

  16. School-based physical therapy services and student functional performance at school.

    Science.gov (United States)

    Mccoy, Sarah Westcott; Effgen, Susan K; Chiarello, Lisa A; Jeffries, Lynn M; Villasante Tezanos, Alejandro G

    2018-03-30

    We explored relationships of school-based physical therapy to standardized outcomes of students receiving physical therapy. Using a practice-based evidence research design, School Function Assessment (SFA) outcomes of 296 students with disabilities (mean age 7y 4mo [standard deviation 2y]; 166 males, 130 females), served by 109 physical therapists, were explored. After training, therapists completed 10 SFA scales on students at the beginning and end of the school year. Therapists collected detailed weekly data on services (activities, interventions, types, student participation) using the School-Physical Therapy Interventions for Pediatrics (S-PTIP) system. Stepwise linear regressions were used to investigate S-PTIP predictors of SFA outcomes. Predictors of SFA section outcomes varied in strength, with the coefficient of determination (R 2 ) for each outcome ranging from 0.107 to 0.326. Services that correlated positively with the SFA outcomes included mobility, sensory, motor learning, aerobic/conditioning, functional strengthening, playground access interventions, and higher student participation during therapy (standardized β=0.11-0.26). Services that correlated negatively with the SFA outcomes included providing services within student groups, within school activity, with students not in special education, during recreation activities, and with positioning, hands-on facilitation, sensory integration, orthoses, and equipment interventions (standardized β=-0.14 to -0.22). Consideration of outcomes is prudent to focus services. Overall results suggest we should emphasize active mobility practice by using motor learning interventions and engaging students within therapy sessions. No specific interventions predicted positively on all School Function Assessment (SFA) outcomes. Active movement practice seems related to overall better SFA outcomes. Active mobility practice improved SFA participation, mobility, recreation, and activities of daily living. Engaging

  17. Equipment considerations

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    Trace or ultratrace analyses require that the HPLC equipment used, including the detector, be optimal for such determinations. HPLC detectors are discussed at length in Chapter 4; discussion here is limited to the rest of the equipment. In general, commercial equipment is adequate for trace analysis; however, as the authors approach ultratrace analysis, it becomes very important to examine the equipment thoroughly and optimize it, where possible. For this reason they will review the equipment commonly used in HPLC and discuss the optimization steps. Detectability in HPLC is influenced by two factors (1): (a) baseline noise or other interferences that lead to errors in assigning the baseline absorbance; (b) peak width. 87 refs

  18. Accelerator beam data commissioning equipment and procedures: Report of the TG-106 of the Therapy Physics Committee of the AAPM

    International Nuclear Information System (INIS)

    Das, Indra J.; Cheng, C.-W.; Watts, Ronald J.; Ahnesjoe, Anders; Gibbons, John; Li, X. Allen; Lowenstein, Jessica; Mitra, Raj K.; Simon, William E.; Zhu, Timothy C.

    2008-01-01

    For commissioning a linear accelerator for clinical use, medical physicists are faced with many challenges including the need for precision, a variety of testing methods, data validation, the lack of standards, and time constraints. Since commissioning beam data are treated as a reference and ultimately used by treatment planning systems, it is vitally important that the collected data are of the highest quality to avoid dosimetric and patient treatment errors that may subsequently lead to a poor radiation outcome. Beam data commissioning should be performed with appropriate knowledge and proper tools and should be independent of the person collecting the data. To achieve this goal, Task Group 106 (TG-106) of the Therapy Physics Committee of the American Association of Physicists in Medicine was formed to review the practical aspects as well as the physics of linear accelerator commissioning. The report provides guidelines and recommendations on the proper selection of phantoms and detectors, setting up of a phantom for data acquisition (both scanning and no-scanning data), procedures for acquiring specific photon and electron beam parameters and methods to reduce measurement errors (<1%), beam data processing and detector size convolution for accurate profiles. The TG-106 also provides a brief discussion on the emerging trend in Monte Carlo simulation techniques in photon and electron beam commissioning. The procedures described in this report should assist a qualified medical physicist in either measuring a complete set of beam data, or in verifying a subset of data before initial use or for periodic quality assurance measurements. By combining practical experience with theoretical discussion, this document sets a new standard for beam data commissioning

  19. Technology and equipment based on induction melters with ''cold'' crucible for reprocessing active metal waste

    International Nuclear Information System (INIS)

    Pastushkov, V.G.; Molchanov, A.V.; Serebryakov, V.P.; Smelova, T.V.; Shestoperov, I.N.

    2000-01-01

    The operation and, particularly, the decommissioning of NPPs and radiochemical plants result in substantial arisings of radioactive metal waste (RAMW) having different activity levels (from 5 x 10 -4 to ∼ 40 Ci/kg). The paper reviews the specific features of the technology and equipment used to melt RAMW in electric arc and induction furnaces with ceramic or 'cold' crucibles. The experimentally determined and calculated data are given on the level to which RAMW is decontaminated from the main radionuclides as well as on the distribution of the latter in the products of melting (ingot, slag, gaseous phase). Special attention is focused on the process and the facility for the induction-slag melting of RAMW in furnaces equipped with 'cold' crucibles. The work is described that is under way at SSC RF VNIINM to master the technology of melting simulated high activity level Zr-alloy and stainless steel waste. (authors)

  20. A typewriting system operated by head movements, based on home-computer equipment.

    Science.gov (United States)

    Heuvelmans, A M; Mélotte, H E; Neve, J J

    1990-06-01

    For persons who cannot move their hands and legs we have designed a relatively inexpensive typewriting system which can be operated by movements of the head. The typewriter is made up of commercially available home computer equipment - i e, a computer including monitor and printer and a headset replacing the mouse. A user-friendly software program has been designed to replace the mouse button and to make this equipment act as a typewriter with simple text-editing features. Some ergonomics aspects of the typewriter set-up and the results of an evaluation of the typewriter by two patients suffering from amyotrophic lateral sclerosis (ALS) are given. Several factors relevant to the design, construction, evaluation and application of the typewriter are discussed.

  1. An engineering development of fluoroscopic X-ray medical equipment based-on fluorescent screen

    International Nuclear Information System (INIS)

    Ferry Suyatno; I Putu Susila; Djoko Sukmono

    2011-01-01

    Fluoroscopic x-ray medical equipment uses fluorescent screen to capture structural image of organs. Unlike conventional x-ray equipment which uses film, in the fluoroscopic x-ray, the resulting image is visualized on the fluorescent screen and directly observed by physicians in the patients' rooms. In this study, we developed an image capture system that transforms the image on the fluorescent screen into digital data, which is then transferred to computer for visualization and further processing. By using this system, the observation of the resulting image can be done on a computer that is placed in the control room. The image can also be stored easily and at low cost compared to conventional film. The experiment shows that the system could be used to capture image of the object. However, its quality needs to be improved. In the future, the system will be modified and tested with different types of cameras to obtain better results. (author)

  2. Qualification test of Class 1E equipment based on IEEE323 Std 2003

    International Nuclear Information System (INIS)

    Kim, J. S.; Jung, S. C.; Kim, T. R.

    2004-01-01

    IEEE Standard for Qualifying Class 1E Equipment has been updated to 2003 edition since the issue of IEEE Std 323-1971, 1974, 1983. NRC approved the IEEE Std 323-1974 as Qualification standard of Class 1E Equipment in domestic nuclear power plant. IEEE Std 323-2003 was issued in September of 2003 and utility is waiting the approval of NRC. IEEE Std 323-2003 suggest a new qualification technique which adopts the condition monitoring. Performance of two transient during DBA test is no longer recommended in IEEE Std 323-2003. IEEE323 Std 2003 included a chapter of ''extension of Qualified life'' to make available the life extension of components during plant life extension. For the efficient control of preserving EQ in domestic nuclear power plant, IEEE323 Std 2003 is strongly recommended

  3. Life Cycle Management for Equipments in Nuclear Plants Based on Reliability

    International Nuclear Information System (INIS)

    Wang Dalin; Sun Jinlong

    2012-01-01

    Majority of equipments in nuclear power stations are not un-repairable, but repaired after failures or maintained periodically and then returned to running. Along with aging or fatigue causes, duration between failures may be variable such as larger or shorter. Equipments failure occurrences are consistent with non-homogeneous Poisson process (NHPP), in which their failure rates are variable. We chose Weibull process to simplify the actual circumstances to obtain the optimal life cycle management plans approximately. In application we need to estimate parameters of Weibull process with existing data. Before that, trend test is necessary. Total time test (TTT) is an alternative. Trend test can determine whether the failure rate changes along operating time and whether the devices operated under imperfect or minimal repair. Parameters of Weibull process λ, β can be estimated by maximum likelihood estimation method. LCM model is designed to found an optimizing model for those aging equipments under minimal repair or imperfect maintenance with maximum economic or availability as objective function. The purpose is to establish the optimal replacement strategies. Periodical replacement is the most regular choice and so LCM model aims to calculate the optimal replacement periodical duration.

  4. Equipment-based Pilates reduces work-related chronic low back pain and disability: A pilot study.

    Science.gov (United States)

    Stieglitz, Dana Duval; Vinson, David R; Hampton, Michelle De Coux

    2016-01-01

    This study investigated effectiveness of an equipment-based Pilates protocol for reducing pain and disability in individuals with work-related chronic low back pain (CLBP). Twelve workers with non-specific CLBP participated in a quasi-experimental, one-group, pretest-posttest pilot study of supervised 6-week equipment-based Pilates exercise. Pain severity was assessed using a 100-mm visual analog scale (VAS). Physical function was assessed using the Oswestry disability index (ODI). The Pilates intervention significantly reduced pain (mean decrease in VAS 30.75 ± 20.27, p Pilates exercise reduced pain and disability in workers with CLBP. Further research is needed to investigate Pilates exercise for rehabilitation of work-related injuries in large populations. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. The new Wuerzburg data base for radiation therapy

    International Nuclear Information System (INIS)

    Richter, J.; Richter, E.; Tausch, J.

    1991-01-01

    Conception, structure and realisation of a new data base for radiation therapy are present. The data base utilizes the commercial data base system ORACLE and the data base language SQL. A program package for statistical analyses including Kaplan-Meier-calculations, logrank test and Gehan/Breslow test was elaborated. The input of the data recorded on form sheets is carried out on a data base of the Tumor Centre in the first instance. From there the data are transfered to the ORACLE data base. Up to now the courses of disease of about 13 000 patients are stored. Therefore, extensive and detailed statistical analyses are practicable. (orig.) [de

  6. Space Heating Equipment

    Energy Technology Data Exchange (ETDEWEB)

    Rafferty, Kevin D.

    1998-01-01

    The performance evaluation of space heating equipment for a geothermal application is generally considered from either of two perspectives: (a) selecting equipment for installation in new construction, or (b) evaluating the performance and retrofit requirements of an existing system. With regard to new construction, the procedure is relatively straightforward. Once the heating requirements are determined, the process need only involve the selection of appropriately sized hot water heating equipment based on the available water temperature. It is important to remember that space heating equipment for geothermal applications is the same equipment used in non-geothermal applications. What makes geothermal applications unique is that the equipment is generally applied at temperatures and flow rates that depart significantly from traditional heating system design. This chapter presents general considerations for the performance of heating equipment at non-standard temperature and flow conditions, retrofit of existing systems, and aspects of domestic hot water heating.

  7. Development of standardized component\\0x2010based equipment specifications and transition plan into a predictive maintenance strategy.

    Science.gov (United States)

    2015-12-01

    This project investigated INDOT equipment records and equipment industry standards to produce standard equipment specifications : and a predictive maintenance schedule for the more than 1100 single and tandem axle trucks in use at INDOT. The research...

  8. Development of standardized component\\0x2010based equipment specifications and transition plan into a predictive maintenance strategy : final report.

    Science.gov (United States)

    2015-12-01

    This project investigated INDOT equipment records and equipment industry standards to produce standard equipment specifications : and a predictive maintenance schedule for the more than 1100 single and tandem axle trucks in use at INDOT. The research...

  9. Automatic differentiation for gradient-based optimization of radiatively heated microelectronics manufacturing equipment

    Energy Technology Data Exchange (ETDEWEB)

    Moen, C.D.; Spence, P.A.; Meza, J.C.; Plantenga, T.D.

    1996-12-31

    Automatic differentiation is applied to the optimal design of microelectronic manufacturing equipment. The performance of nonlinear, least-squares optimization methods is compared between numerical and analytical gradient approaches. The optimization calculations are performed by running large finite-element codes in an object-oriented optimization environment. The Adifor automatic differentiation tool is used to generate analytic derivatives for the finite-element codes. The performance results support previous observations that automatic differentiation becomes beneficial as the number of optimization parameters increases. The increase in speed, relative to numerical differences, has a limited value and results are reported for two different analysis codes.

  10. Establishment of Low Energy Building materials and Equipment Database Based on Property Information

    Science.gov (United States)

    Kim, Yumin; Shin, Hyery; eon Lee, Seung

    2018-03-01

    The purpose of this study is to provide reliable service of materials information portal through the establishment of public big data by collecting and integrating scattered low energy building materials and equipment data. There were few cases of low energy building materials database in Korea have provided material properties as factors influencing material pricing. The framework of the database was defined referred with Korea On-line E-procurement system. More than 45,000 data were gathered by the specification of entities and with the gathered data, price prediction models for chillers were suggested. To improve the usability of the prediction model, detailed properties should be analysed for each item.

  11. Avatar-Based Therapy within Prison Settings: Pilot Evaluation

    Science.gov (United States)

    van Rijn, Biljana; Cooper, Mick; Jackson, Andrew; Wild, Ciara

    2017-01-01

    The paper presents an introduction of a newly developed, avatar-based virtual reality therapy, as an addition to the therapeutic programme, within a therapeutic community prison in the UK. The participants had six group sessions facilitated by a counsellor. The aim of the project was to investigate whether this approach would improve mental health…

  12. Methadone maintenance therapy as evidence based drug abuse ...

    African Journals Online (AJOL)

    Methadone maintenance therapy as evidence based drug abuse planning in ... drugs are being used as artificial problem-solvers such as frustrations, stress or ... Drug use is a problem to users when it begins to cause some damage to their ...

  13. Mindfulness-based cognitive therapy to treat multiple chemical sensitivities

    DEFF Research Database (Denmark)

    Skovbjerg, S; Hauge, Christian Riis; Rasmussen, Alice

    2012-01-01

    of an 8-week mindfulness-based cognitive therapy program (MBCT) for adults with MCS and to evaluate possible effects on psychological distress and illness perception. The study design was a randomized clinical trial. The MBCT programme comprised 8 weekly sessions of 2½ hours. Forty-two adults were...

  14. A Randomized Controlled Trial of Acceptance-Based Behavior Therapy and Cognitive Therapy for Test Anxiety: A Pilot Study

    Science.gov (United States)

    Brown, Lily A.; Forman, Evan M.; Herbert, James D.; Hoffman, Kimberly L.; Yuen, Erica K.; Goetter, Elizabeth M.

    2011-01-01

    Many university students suffer from test anxiety that is severe enough to impair performance. Given mixed efficacy results of previous cognitive-behavior therapy (CBT) trials and a theoretically driven rationale, an acceptance-based behavior therapy (ABBT) approach was compared to traditional CBT (i.e., Beckian cognitive therapy; CT) for the…

  15. Trends in spread of the particle therapy of cancers to areal bases

    International Nuclear Information System (INIS)

    Abe, Mitsuyuki; Aoki, Takashi; Tsujii, Hirohiko

    2009-01-01

    In Japan, the rate of cancer death accounts for 30%, now there are 8 facilities having the cancer particle therapy (PT) which is promising due to its highly effective, short term, non-surgical, not always expensive treatment, and local areas have tended to construct such facility for their people. This special article describes trends in the title concerning the areal intention for setting up the therapeutic bases, global trend of PT, research and development in manufacturers of PT equipments, and response of health insurer to the trend. The article contains following 15 topics presented by 15 authors or groups of the academia, official and company institutes, prefectural officers, manufacturers and an insurer, and by Editorial. Topics are: Significance and future view of PT in cancer treatment; Present state of construction of PT facilities in various areas; Fifteen year-results of PT in near-infrared spectroscopy (NIRS) and its effort to spread the therapy; Gumma University's 21st century program COE (Center of Excellence), Medical and Biological Studies with Accelerator Technology; Project for constructing Fukui Prefectural Proton PT Center; The role of Proton PT Center in southern Tohoku area as the first private facility; PT center by Foundation of Medipolis Medical Research Institute in southern Kyushu area; Global trend of PT; Spread of PT and the role of health insurance in it/Mitsui-Sumitomo's health insurance, Kirameki, the contribution to general public; Mitsubishi Electric Corp.'s effort to spread PT equipments; Toshiba's effort; Hitachi's effort; Sumitomo Heavy Industries' effort; Effort by Chiyoda Technol Corp. and Still River Systems to develop the next generation superconducting PT equipment; and Overview by Editorial/Complicated trend in invitation and construction of PT facilities. (K.T.)

  16. The use of Selectron afterloading equipment to simulate and extend the Manchester system for intracavitary therapy of the cervix uteri

    International Nuclear Information System (INIS)

    Wilkinson, J.M.; Moore, C.J.; Notley, H.M.; Hunter, R.D.

    1983-01-01

    When Selectron afterloading machines were introduced in the Christie Hospital the first aim was to reproduce, as closely as possible, the isodose distributions achieved with the traditional Manchester Radium System. This resulted in the establishment of standard pellet loading patterns, and standard treatment times, for programming the Selectron channels. However, the availability of whole-body CT scanning facilities provides a method of accurately locating the source positions with respect to the local anatomy and hence the possibility of dosage control based on doses to specific pelvic structures. Various computer programs have been written to extract source position data from the CT images, to allow the operator to propose pellet loading patterns and treatment times, and ultimately to display the resultant isodose distribution superposed on the cross-sectional scans. The effects on the dose distribution arising from changing the number of pellets, the pellet positions within the applicators, and the treatment times, are briefly discussed. (author)

  17. A hybrid degradation tendency measurement method for mechanical equipment based on moving window and Grey–Markov model

    International Nuclear Information System (INIS)

    Jiang, Wei; Zhou, Jianzhong; Zheng, Yang; Liu, Han

    2017-01-01

    Accurate degradation tendency measurement is vital for the secure operation of mechanical equipment. However, the existing techniques and methodologies for degradation measurement still face challenges, such as lack of appropriate degradation indicator, insufficient accuracy, and poor capability to track the data fluctuation. To solve these problems, a hybrid degradation tendency measurement method for mechanical equipment based on a moving window and Grey–Markov model is proposed in this paper. In the proposed method, a 1D normalized degradation index based on multi-feature fusion is designed to assess the extent of degradation. Subsequently, the moving window algorithm is integrated with the Grey–Markov model for the dynamic update of the model. Two key parameters, namely the step size and the number of states, contribute to the adaptive modeling and multi-step prediction. Finally, three types of combination prediction models are established to measure the degradation trend of equipment. The effectiveness of the proposed method is validated with a case study on the health monitoring of turbine engines. Experimental results show that the proposed method has better performance, in terms of both measuring accuracy and data fluctuation tracing, in comparison with other conventional methods. (paper)

  18. A hybrid degradation tendency measurement method for mechanical equipment based on moving window and Grey-Markov model

    Science.gov (United States)

    Jiang, Wei; Zhou, Jianzhong; Zheng, Yang; Liu, Han

    2017-11-01

    Accurate degradation tendency measurement is vital for the secure operation of mechanical equipment. However, the existing techniques and methodologies for degradation measurement still face challenges, such as lack of appropriate degradation indicator, insufficient accuracy, and poor capability to track the data fluctuation. To solve these problems, a hybrid degradation tendency measurement method for mechanical equipment based on a moving window and Grey-Markov model is proposed in this paper. In the proposed method, a 1D normalized degradation index based on multi-feature fusion is designed to assess the extent of degradation. Subsequently, the moving window algorithm is integrated with the Grey-Markov model for the dynamic update of the model. Two key parameters, namely the step size and the number of states, contribute to the adaptive modeling and multi-step prediction. Finally, three types of combination prediction models are established to measure the degradation trend of equipment. The effectiveness of the proposed method is validated with a case study on the health monitoring of turbine engines. Experimental results show that the proposed method has better performance, in terms of both measuring accuracy and data fluctuation tracing, in comparison with other conventional methods.

  19. AT89S52 Microcontroller Based A Speed Restraint Equipment for Motorcycle

    Directory of Open Access Journals (Sweden)

    Ikhsan hidayat

    2009-08-01

    Full Text Available Security riding is very important in the aspects of traffic. One of the main factors of traffic accidents is high speed. Therefore, it is required a speed restraint equipment for pressing the number of accidents. The car speed restraint system is available in the market, but on a motorcycle is not available yet. This paper presents a design of speed restraint equipment for motorcycle that safe for users, and is expected to reduce traffic accident. The Main idea this speed restriction is cutting off the flow of electrical signals from the pulser (the time ignition trigger sensor to the CDI for 1 second. The cutting Signal with mechanical relays controlled by microcontroller AT89S52 using the on-off algorithm. Speed sensor use optocoupler is used to detect the number of rounds wheel motorcycle. If a result of measurement is more than the speed setpoint, microcontroler make a decission to cut motorcycle ignition signal. Results of this research is a prototype speed restraint shown that it able to process data from the measurement of the speed limit on the speed of a motorcycle. This prototype safe for all users and accordance with the set value and the level of success is above 90% for speed of 10 km/hr to 40 km/hr.

  20. Hall-effect based semi-fast AC on-board charging equipment for electric vehicles.

    Science.gov (United States)

    Milanés-Montero, María Isabel; Gallardo-Lozano, Javier; Romero-Cadaval, Enrique; González-Romera, Eva

    2011-01-01

    The expected increase in the penetration of electric vehicles (EV) and plug-in hybrid electric vehicles (PHEV) will produce unbalanced conditions, reactive power consumption and current harmonics drawn by the battery charging equipment, causing a great impact on the power quality of the future smart grid. A single-phase semi-fast electric vehicle battery charger is proposed in this paper. This ac on-board charging equipment can operate in grid-to-vehicle (G2V) mode, and also in vehicle-to-grid (V2G) mode, transferring the battery energy to the grid when the vehicle is parked. The charger is controlled with a Perfect Harmonic Cancellation (PHC) strategy, contributing to improve the grid power quality, since the current demanded or injected has no harmonic content and a high power factor. Hall-effect current and voltage transducers have been used in the sensor stage to carry out this control strategy. Experimental results with a laboratory prototype are presented.

  1. Report based on fiscal 2000 diagnostic X-ray equipment questionnaire survey. Conditions of radiography

    Energy Technology Data Exchange (ETDEWEB)

    Ishikawa, Mitsuo [Kitasato Univ., Sagamihara, Kanagawa (Japan). School of Allied Health Sciences; Matsuura, Takatoshi [Sekishinkai Sayama Hospital, Saitama (Japan); Okuaki, Tomoyuki; Imai, Yoshio; Tsukamoto, Atsuko [Kanto Medical Center NTT EC, Tokyo (Japan); Ide, Toshinori [Kajima Corp., Tokyo (Japan). Kajima Clinic; Shinohara, Fuminori [Nippon Medical School, Kawasaki, Kanagawa (Japan). Second Hospital; Miyazaki, Shigeru [Toho Univ., Tokyo (Japan). Ohashi Hospital

    2002-08-01

    X-ray equipment has seen advances in inverters and the digitalization of reception systems. The X-ray Systems Study Group, in order to examine changes in the conditions of radiography, including pediatric radiography, variations in shortest irradiation time, and standardization of the conditions of radiography, carried out investigative research using a questionnaire survey that was sent to 400 facilities. The recovery rate was 33%. In terms of the reception system, half of the general radiography systems were using computed radiography (CR). Seventy percent of respondents used an intensifying screen and film (SEF) in stomach double-contrast radiography. About 80% used digital radiography (DR) and digital subtraction angiography (DSA) in aorta abdominalis angiography. At least 70% of high-voltage generators were of the inverter type. The conditions of radiography were not greatly influenced by changes in reception systems and X-ray equipment. Many pediatric radiographies were carried out by radiological technologists. We consider it useful to conduct such survey investigations. (author)

  2. [Report based on fiscal 2000 diagnostic x-ray equipment questionnaire survey(conditions of radiography)].

    Science.gov (United States)

    Ishikawa, Mitsuo; Matsuura, Takatoshi; Okuaki, Tomiyuki; Imai, Yoshio; Tsukamoto, Atsuko; Ide, Toshinori; Shinohara, Fuminori; Miyazaki, Shigeru

    2002-08-01

    X-ray equipment has seen advances in inverters and the digitalization of reception systems. The X-ray Systems Study Group, in order to examine changes in the conditions of radiography, including pediatric radiography, variations in shortest irradiation time, and standardization of the conditions of radiography, carried out investigative research using a questionnaire survey that was sent to 400 facilities. The recovery rate was 33%. In terms of the reception system, half of the general radiography systems were using computed radiography (CR). Seventy percent of respondents used an intensifying screen and film(S EF)in stomach double-contrast radiography. About 80% used digital radiography (DR) and digital subtraction angiography (DSA) in aorta abdominalis angiography. At least 70% of high-voltage generators were of the inverter type. The conditions of radiography were not greatly influenced by changes in reception systems and X-ray equipment. Many pediatric radiographies were carried out by radiological technologists. We consider it useful to conduct such survey investigations.

  3. Cell therapy medicinal product regulatory framework in Europe and its application for MSC based therapy development

    Directory of Open Access Journals (Sweden)

    Janis eAncans

    2012-08-01

    Full Text Available Advanced therapy medicinal products (ATMPs, including cell therapy products, form a new class of medicines in the European Union. Since ATMPs are at the forefront of scientific innovation in medicine, specific regulatory framework has been developed for these medicines and implemented from 2009. The Committee for Advanced Therapies (CAT has been established at European Medicines Agency (EMA for centralized classification, certification and evaluation procedures, and other ATMP related tasks. Guidance documents, initiatives and interaction platforms are available to make the new framework more accessible for small and medium-sized enterprises, academia, hospitals and foundations. Good understanding of centralised and national components of the regulatory system is required to plan product development. It is in the best interests of cell therapy developers to utilise provided resources starting with the preclinical stage. Whilst there have not been mesenchymal stem cell (MSC based medicine authorisations in the EU, three MSC products have received marketing approval in other regions since 2011. Information provided on regulatory requirements, procedures and initiatives is aimed to facilitate MSC based medicinal product development and authorisation in the EU.

  4. DNA nanostructure-based drug delivery nanosystems in cancer therapy.

    Science.gov (United States)

    Wu, Dandan; Wang, Lei; Li, Wei; Xu, Xiaowen; Jiang, Wei

    2017-11-25

    DNA as a novel biomaterial can be used to fabricate different kinds of DNA nanostructures based on its principle of GC/AT complementary base pairing. Studies have shown that DNA nanostructure is a nice drug carrier to overcome big obstacles existing in cancer therapy such as systemic toxicity and unsatisfied drug efficacy. Thus, different types of DNA nanostructure-based drug delivery nanosystems have been designed in cancer therapy. To improve treating efficacy, they are also developed into more functional drug delivery nanosystems. In recent years, some important progresses have been made. The objective of this review is to make a retrospect and summary about these different kinds of DNA nanostructure-based drug delivery nanosystems and their latest progresses: (1) active targeting; (2) mutidrug co-delivery; (3) construction of stimuli-responsive/intelligent nanosystems. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. A New Approach to Detection of Systematic Errors in Secondary Substation Monitoring Equipment Based on Short Term Load Forecasting

    Directory of Open Access Journals (Sweden)

    Javier Moriano

    2016-01-01

    Full Text Available In recent years, Secondary Substations (SSs are being provided with equipment that allows their full management. This is particularly useful not only for monitoring and planning purposes but also for detecting erroneous measurements, which could negatively affect the performance of the SS. On the other hand, load forecasting is extremely important since they help electricity companies to make crucial decisions regarding purchasing and generating electric power, load switching, and infrastructure development. In this regard, Short Term Load Forecasting (STLF allows the electric power load to be predicted over an interval ranging from one hour to one week. However, important issues concerning error detection by employing STLF has not been specifically addressed until now. This paper proposes a novel STLF-based approach to the detection of gain and offset errors introduced by the measurement equipment. The implemented system has been tested against real power load data provided by electricity suppliers. Different gain and offset error levels are successfully detected.

  6. Mindfulness-based cognitive therapy for depression: trends and developments.

    Science.gov (United States)

    MacKenzie, Meagan B; Kocovski, Nancy L

    2016-01-01

    Mindfulness-based cognitive therapy (MBCT) was developed as a psychological intervention for individuals at risk of depressive relapse. Possible mechanisms of change for this intervention are in line with its theoretical underpinnings, and include increases in mindfulness and/or decreases in negative repetitive thoughts. This review provides an overview of current trends in MBCT research, including efficacy and questions regarding the specific effects of MBCT in light of recent comparisons with structurally equivalent control conditions, mechanisms of change, and moderators of treatment outcome. In addition, future directions are discussed, such as challenges with training an adequate number of therapists and disseminating this therapy.

  7. Calculation of the structural shielding of the radiotherapy treatment room equipped with a linear accelerator type Tomo therapy Hi-Art in the Oncology Center of Chihuahua, Mexico; Calculo del blindaje estructural de la sala de tratamiento de radioterapia equipada con un acelerador lineal del tipo Tomotherapy Hi-Art en el Centro Oncologico de Chihuahua, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Caballero G, C. A. [Southwest Oncology Centers, North Civic Center Plaza No. 2926, Scottsdale, Arizona (United States); Plascencia, J. C. [Centro Oncologico Louis and Lucille Grado, Republica del Peru No. 102-5, Col. Americas, Aguascalientes (Mexico); Vargas V, M. X.; Toledo J, P., E-mail: cabshm@msn.co [Centro Oncologico de Chihuahua, Hacienda de la Esperanza No. 6304, Fracc. Cima Comercial, Chihuahua (Mexico)

    2010-09-15

    The helicoid tomo therapy is an external radiotherapy system of modulated intensity, guided by image, in which the radiation is imparted to the patient using a narrow radiation beam in helicoid form, in a similar way to the scanning process with a computerized tomography. The tomo therapy equipment (Tomo Therapy Hi-Art) consists in an electrons linear accelerator with acceleration voltages of 6 MV for treatment and 3.5 MV for image, coupled to a ring that turn around the patient as this is transferred through this ring in perpendicular sense to the radiation beam. The radiation beam is narrow because has the maximum size of 5 x 40 cm{sup 2} in the isocenter. The intensity modulation of the beam is carried out with a binary dynamic collimator of 64 crisscross sheets, and the guide by image though a system of megavoltage computerized tomography. Opposed to the radiation beam, also coupled to the rotational ring, a group of lead plates exists with a total thickness of 13 cm that acts as barrier of the primary radiation beam. The special configuration of the tomography equipment makes to have the following characteristics: 1) the presence of the lead barrier of the equipment reduces the intensity of the primary beam that reaches the bunker walls in considerable way, 2) the disperse and leakage radiations are increased with regard to a conventional accelerator due to the increase in the necessary irradiation time to produce modulated intensity fields by means of the narrow radiation beam. These special characteristics of the tomo therapy equipment make that particularities exist in the application of the formulations for structural shielding calculations that appears in the NCRP reports 49, NCRP 151 and IAEA-SRS-47. For this reason, several researches have development analytic models based on geometric considerations of continuous rotation of the equipment ring to determine the shielding requirements for the primary beam, the dispersed and leakage radiation in tomo

  8. Investigating the experiences in a school-based occupational therapy program to inform community-based paediatric occupational therapy practice.

    Science.gov (United States)

    Rens, Lezahn; Joosten, Annette

    2014-06-01

    A collaborative approach with teachers is required when providing community-based occupational therapy to educationally at risk children. Collaborators share common goals and interact and support each other but challenges arise in providing collaborative occupational therapy in settings outside the school environment. The aim of this study was to capture experiences of teachers and occupational therapists working within a school-based occupational therapy program to determine if their experiences could inform collaborative practice. In this pilot study, participant responses to questionnaires (n = 32) about their experiences formed the basis for focus groups and individual interviews. Two focus group were conducted, one with teachers (n = 11) and one with occupational therapy participants (n = 6). Individual interviews were conducted with the supervising occupational therapist, school principal and two leading teachers. Descriptive statistics were used to analyse the data from closed questions, and thematic analysis using a constant comparison approach was used to analyse open ended questions, focus groups and interviews. Three main themes emerged: (i) the need for occupational therapists to spend time in the school, to explain their role, build relationships, understand classroom routines and the teacher role; (ii) occupational therapists need to not see themselves as the expert but develop equal partnerships to set collaborative goals and (iii) occupational therapists advocating for all parties to be informed throughout the occupational therapy process. The pilot study findings identified teacher and therapist experiences within the school setting that could inform improved collaborative practice with teachers and community-based occupational therapists and these findings warrant further investigation. © 2013 Occupational Therapy Australia.

  9. Accelerator based neutron source for neutron capture therapy

    International Nuclear Information System (INIS)

    Salimov, R.; Bayanov, B.; Belchenko, Yu.; Belov, V.; Davydenko, V.; Donin, A.; Dranichnikov, A.; Ivanov, A.; Kandaurov, I; Kraynov, G.; Krivenko, A.; Kudryavtsev, A.; Kursanov, N.; Savkin, V.; Shirokov, V.; Sorokin, I.; Taskaev, S.; Tiunov, M.

    2004-01-01

    Full text: The Budker Institute of Nuclear Physics (Novosibirsk) and the Institute of Physics and Power Engineering (Obninsk) have proposed an accelerator based neutron source for neutron capture and fast neutron therapy for hospital. Innovative approach is based upon vacuum insulation tandem accelerator (VITA) and near threshold 7 Li(p,n) 7 Be neutron generation. Pilot accelerator based neutron source for neutron capture therapy is under construction now at the Budker Institute of Nuclear Physics, Novosibirsk, Russia. In the present report, the pilot facility design is presented and discussed. Design features of facility components are discussed. Results of experiments and simulations are presented. Complete experimental tests are planned by the end of the year 2005

  10. Nanomedicine for cancer therapy from chemotherapeutic to hyperthermia-based therapy

    CERN Document Server

    Kumar, Piyush

    2017-01-01

    This Brief focuses on the cancer therapy available till date, from conventional drug delivery to nanomedicine in clinical trial. In addition, it reports on future generation based nanotherapeutics and cancer theranostic agent for effective therapeutic diagnosis and treatment. Breast cancer was chosen as the model system in this review. The authors give emphasis to multiple drug resistance (MDR) and its mechanism and how to overcome it using the nanoparticle approach. .

  11. Comparison of dose-volume histograms for Tomo therapy, linear accelerator-based 3D conformal radiation therapy, and intensity-modulated radiation therapy

    International Nuclear Information System (INIS)

    Ji, Youn-Sang; Dong, Kyung-Rae; Kim, Chang-Bok; Choi, Seong-Kwan; Chung, Woon-Kwan; Lee, Jong-Woong

    2011-01-01

    Highlights: → Evaluation of DVH from 3D CRT, IMRT and Tomo therapy was conducted for tumor therapy. → The doses of GTV and CTV were compared using DVHs from 3D CRT, IMRT and Tomo therapy. → The GTV was higher when Tomo therapy was used, while the doses of critical organ were low. → They said that Tomo therapy satisfied the goal of radiation therapy more than the others. - Abstract: Evaluation of dose-volume histograms from three-dimensional conformal radiation therapy (3D CRT), intensity-modulated radiation therapy (IMRT), and Tomo therapy was conducted. These three modalities are among the diverse treatment systems available for tumor therapy. Three patients who received tumor therapy for a malignant oligodendroglioma in the cranium, nasopharyngeal carcinoma in the cervical neck, and prostate cancer in the pelvis were selected as study subjects. Therapy plans were made for the three patients before dose-volume histograms were obtained. The doses of the gross tumor volume (GTV) and the clinical target volume (CTV) were compared using the dose-volume histograms obtained from the LINAC-based 3D CRT, IMRT planning station (Varian Eclipse-Varian, version 8.1), and Tomo therapy planning station. In addition, the doses of critical organs in the cranium, cervix, and pelvis that should be protected were compared. The GTV was higher when Tomo therapy was used compared to 3D CRT and the LINAC-based IMRT, while the doses of critical organ tissues that required protection were low. These results demonstrated that Tomo therapy satisfied the ultimate goal of radiation therapy more than the other therapies.

  12. [Proangiogenic cell-based therapy for treatment of ischemic diseases].

    Science.gov (United States)

    Silvestre, Jean-Sébastien

    2009-11-01

    The application of endothelial progenitor cells (EPC) cell-based therapy for regenerative medicine constitutes a promising therapeutic avenue for the treatment of cardiovascular diseases. Based on experimental studies demonstrating that bone marrow-, blood- or tissue-derived stem/progenitor cells improve the functional recovery after ischemia, clinical trials were initiated to address this new therapeutic concept. Although autolougous cell therapy was shown to improve perfusion and function of ischemic tissues, a number of issues remain to be adressed. The nature of the mobilizing, migratory and homing signals, and the mechanisms of action need to be identified and further defined. In addition, strategies to enhance homing, survival and therapeutic potential of EPC need to be developped to improve therapeutic effect and counteract EPC dysfunction in aged patients with cardiovascular risk factors. The present review article will discuss the mechanisms of action of different types of adult stem cells and several approaches to improve their therapeutic efficiency.

  13. Acceptance-based behavior therapy to promote HIV medication adherence.

    Science.gov (United States)

    Moitra, Ethan; Herbert, James D; Forman, Evan M

    2011-12-01

    A significant number of adults with HIV in the USA do not maintain adherence to highly active antiretroviral therapy (HAART) at adequate levels. Although traditional cognitive behavioral interventions have shown promise in promoting HAART adherence, acceptance-based behavior therapy (ABBT) may be particularly useful in this population. ABBT has the potential to overcome common avoidance-based barriers associated with poor adherence, including denial of various illness-related factors and avoidance of stigmatization. We describe the rationale for promoting psychological and behavioral acceptance in HIV-positive populations; outline an ABBT to promote HAART adherence targeting primary care patients from urban, minority, low socioeconomic backgrounds; and report preliminary qualitative observations of treatment feasibility and acceptability.

  14. Mindfulness-based cognitive therapy for depression: trends and developments

    OpenAIRE

    MacKenzie, Meagan B; Kocovski, Nancy L

    2016-01-01

    Meagan B MacKenzie,1 Nancy L Kocovski21Department of Psychology, Ryerson University, Toronto, ON, Canada; 2Department of Psychology, Wilfrid Laurier University, Waterloo, ON, CanadaAbstract: Mindfulness-based cognitive therapy (MBCT) was developed as a psychological intervention for individuals at risk of depressive relapse. Possible mechanisms of change for this intervention are in line with its theoretical underpinnings, and include increases in mindfulness and/or decreases in nega...

  15. Global Regulatory Differences for Gene- and Cell-Based Therapies

    DEFF Research Database (Denmark)

    Coppens, Delphi G M; De Bruin, Marie L; Leufkens, Hubert G M

    2017-01-01

    Gene- and cell-based therapies (GCTs) offer potential new treatment options for unmet medical needs. However, the use of conventional regulatory requirements for medicinal products to approve GCTs may impede patient access and therapeutic innovation. Furthermore, requirements differ between...... jurisdictions, complicating the global regulatory landscape. We provide a comparative overview of regulatory requirements for GCT approval in five jurisdictions and hypothesize on the consequences of the observed global differences on patient access and therapeutic innovation....

  16. Mesenchymal Stem Cell Based Therapy for Prostate Cancer

    Science.gov (United States)

    2015-11-01

    Montero-Menei, C.; Menei, P. Mesenchymal Stem Cells as Cellular Vehicles for Delivery of Nanoparticles to Brain Tumors. Biomaterials 2010, 31, 8393... Stem Cells : Considerations for Regenerative Medicine Approaches. Tissue Eng. Part B. Rev. 2010, 16, 159–168. 55. Ellem, S. J.; Taylor, R. a.; Furic, L...Award Number: W81XWH-13-1-0304 TITLE: Mesenchymal Stem Cell -Based Therapy for Prostate Cancer PRINCIPAL INVESTIGATOR: John Isaacs CONTRACTING

  17. Development of logistic support for space equipment on the base of the “Sail-BMSTU” midget spacecraft

    Directory of Open Access Journals (Sweden)

    Brom Alla

    2016-01-01

    Full Text Available The paper envisages the application of integrated logistic support conception (ILS for space equipment on the base of the example of the student’s «Sail BMSTU» midget spacecraft (MS. The peculiarities of space equipment logistic support in operation phase are considered. The special focus is done to the problem of decrease in production expenses of spacecrafts. The paper suggests that the solution of this problem has to be based on tools commonly used in engineering fields – functional analysis and FMECA. The fragment of FMECA is presented. Due to FMECA it is clear what products in spacecrafts should be calibrated in accordance with quality requirements of military class and what ones should be calibrated in accordance with quality requirements of commercial and industrial classes. Each failure mode of midget spacecraft, identified within FMECA, is studied by assessing of criticality, severity and probability of emergence. The paper describes the main procedures of integrated logistic support on the base of the student’s «Sail MGTU» midget spacecraft. Recommended guidelines providing reliability of electro radio products are elaborated. The practical application of integrated logistic support in aerospace industry is reasonably presented.

  18. Proton Therapy for Skull Base Chordomas: An Outcome Study from the University of Florida Proton Therapy Institute

    OpenAIRE

    Deraniyagala, Rohan L.; Yeung, Daniel; Mendenhall, William M.; Li, Zuofeng; Morris, Christopher G.; Mendenhall, Nancy P.; Okunieff, Paul; Malyapa, Robert S.

    2013-01-01

    Objectives Skull base chordoma is a rare, locally aggressive tumor located adjacent to critical structures. Gross total resection is difficult to achieve, and proton therapy has the conformal advantage of delivering a high postoperative dose to the tumor bed. We present our experience using proton therapy to treat 33 patients with skull base chordomas.

  19. EUD-based biological optimization for carbon ion therapy

    International Nuclear Information System (INIS)

    Brüningk, Sarah C.; Kamp, Florian; Wilkens, Jan J.

    2015-01-01

    Purpose: Treatment planning for carbon ion therapy requires an accurate modeling of the biological response of each tissue to estimate the clinical outcome of a treatment. The relative biological effectiveness (RBE) accounts for this biological response on a cellular level but does not refer to the actual impact on the organ as a whole. For photon therapy, the concept of equivalent uniform dose (EUD) represents a simple model to take the organ response into account, yet so far no formulation of EUD has been reported that is suitable to carbon ion therapy. The authors introduce the concept of an equivalent uniform effect (EUE) that is directly applicable to both ion and photon therapies and exemplarily implemented it as a basis for biological treatment plan optimization for carbon ion therapy. Methods: In addition to a classical EUD concept, which calculates a generalized mean over the RBE-weighted dose distribution, the authors propose the EUE to simplify the optimization process of carbon ion therapy plans. The EUE is defined as the biologically equivalent uniform effect that yields the same probability of injury as the inhomogeneous effect distribution in an organ. Its mathematical formulation is based on the generalized mean effect using an effect-volume parameter to account for different organ architectures and is thus independent of a reference radiation. For both EUD concepts, quadratic and logistic objective functions are implemented into a research treatment planning system. A flexible implementation allows choosing for each structure between biological effect constraints per voxel and EUD constraints per structure. Exemplary treatment plans are calculated for a head-and-neck patient for multiple combinations of objective functions and optimization parameters. Results: Treatment plans optimized using an EUE-based objective function were comparable to those optimized with an RBE-weighted EUD-based approach. In agreement with previous results from photon

  20. Graphene-based nanovehicles for photodynamic medical therapy

    Directory of Open Access Journals (Sweden)

    Li Y

    2015-03-01

    Full Text Available Yan Li,1 Haiqing Dong,1 Yongyong Li,1 Donglu Shi1,2 1Shanghai East Hospital, The Institute for Biomedical Engineering and Nano Science (iNANO, Tongji University School of Medicine, Shanghai, People’s Republic of China; 2The Materials Science and Engineering Program, Department of Mechanical and Materials Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH, USA Abstract: Graphene and its derivatives such as graphene oxide (GO have been widely explored as promising drug delivery vehicles for improved cancer treatment. In this review, we focus on their applications in photodynamic therapy. The large specific surface area of GO facilitates efficient loading of the photosensitizers and biological molecules via various surface functional groups. By incorporation of targeting ligands or activatable agents responsive to specific biological stimulations, smart nanovehicles are established, enabling tumor-triggering release or tumor-selective accumulation of photosensitizer for effective therapy with minimum side effects. Graphene-based nanosystems have been shown to improve the stability, bioavailability, and photodynamic efficiency of organic photosensitizer molecules. They have also been shown to behave as electron sinks for enhanced visible-light photodynamic activities. Owing to its intrinsic near infrared absorption properties, GO can be designed to combine both photodynamic and photothermal hyperthermia for optimum therapeutic efficiency. Critical issues and future aspects of photodynamic therapy research are addressed in this review. Keywords: graphene, nanovehicle, photodynamic therapy, photosensitizer, hyperthermia

  1. Ketogenic Diets: New Advances for Metabolism-Based Therapies

    Science.gov (United States)

    Kossoff, Eric H.; Hartman, Adam L.

    2014-01-01

    Purpose of review Despite myriad anticonvulsants available and in various stages of development, there are thousands of children and adults with epilepsy worldwide still refractory to treatment and not candidates for epilepsy surgery. Many of these patients will now turn to dietary therapies such as the ketogenic diet, medium-chain triglyceride (MCT) diet, modified Atkins diet, and low glycemic index treatment. Recent Findings In the past several years, neurologists are finding new indications to use these dietary treatments, perhaps even as first-line therapy, including infantile spasms, myoclonic-astatic epilepsy (Doose syndrome), Dravet syndrome, and status epilepticus (including FIRES syndrome). Adults are also one of the most rapidly growing populations being treated nowadays; a group of patients previously not typically offered these treatments. In 2009, two controlled trials of the ketogenic diet were published as well as an International Expert Consensus Statement on dietary treatment of epilepsy. Ketogenic diets are also now being increasingly studied for neurologic conditions other than epilepsy, including Alzheimer disease and cancer. Insights from basic science research have helped elucidate the mechanisms by which metabolism-based therapy may be helpful, both in terms of an anticonvulsant and possibly neuroprotective effect. Summary Dietary therapy for epilepsy continues to grow in popularity worldwide, with expanding use for adults and conditions other than epilepsy. PMID:22322415

  2. Clinical results of proton beam therapy for skull base chordoma

    International Nuclear Information System (INIS)

    Igaki, Hiroshi; Tokuuye, Koichi; Okumura, Toshiyuki; Sugahara, Shinji; Kagei, Kenji; Hata, Masaharu; Ohara, Kiyoshi; Hashimoto, Takayuki; Tsuboi, Koji; Takano, Shingo; Matsumura, Akira; Akine, Yasuyuki

    2004-01-01

    Purpose: To evaluate clinical results of proton beam therapy for patients with skull base chordoma. Methods and materials: Thirteen patients with skull base chordoma who were treated with proton beams with or without X-rays at the University of Tsukuba between 1989 and 2000 were retrospectively reviewed. A median total tumor dose of 72.0 Gy (range, 63.0-95.0 Gy) was delivered. The patients were followed for a median period of 69.3 months (range, 14.6-123.4 months). Results: The 5-year local control rate was 46.0%. Cause-specific, overall, and disease-free survival rates at 5 years were 72.2%, 66.7%, and 42.2%, respectively. The local control rate was higher, without statistical significance, for those with preoperative tumors <30 mL. Partial or subtotal tumor removal did not yield better local control rates than for patients who underwent biopsy only as the latest surgery. Conclusion: Proton beam therapy is effective for patients with skull base chordoma, especially for those with small tumors. For a patient with a tumor of <30 mL with no prior treatment, biopsy without tumor removal seems to be appropriate before proton beam therapy

  3. Commissioning of accelerator based boron neutron capture therapy system

    International Nuclear Information System (INIS)

    Nakamura, S.; Wakita, A.; Okamoto, H.; Igaki, H.; Itami, J.; Ito, M.; Abe, Y.; Imahori, Y.

    2017-01-01

    Boron neutron capture therapy (BNCT) is a treatment method using a nuclear reaction of 10 B(n, α) 7 Li. BNCT can be deposited the energy to a tumor since the 10 B which has a higher cross-section to a neutron is high is concentrated on the tumor. It is different from conventional radiation therapies that BNCT expects higher treatment effect to radiation resistant tumors since the generated alpha and lithium particles have higher radiological biological effectiveness. In general, BNCT has been performed in research nuclear reactor. Thus, BNCT is not widely applied in a clinical use. According to recent development of accelerator-based boron neutron capture therapy system, the system has an adequate flux of neutrons. Therefore, National Cancer Canter Hospital, Tokyo, Japan is planning to install accelerator based BNCT system. Protons with 2.5 MeV are irradiated to a lithium target system to generate neutrons. As a result, thermal load of the target is 50 kW since current of the protons is 20.0 mA. Additionally, when the accelerator-based BNCT system is installed in a hospital, the facility size is disadvantage in term of neutron measurements. Therefore, the commissioning of the BNCT system is being performed carefully. In this article, we report about the commissioning. (author)

  4. Glucosamine-Based Supramolecular Nanotubes for Human Mesenchymal Cell Therapy.

    Science.gov (United States)

    Talloj, Satish Kumar; Cheng, Bill; Weng, Jen-Po; Lin, Hsin-Chieh

    2018-04-23

    Herein, we demonstrate an example of glucosamine-based supramolecular hydrogels that can be used for human mesenchymal cell therapy. We designed and synthesized a series of amino acid derivatives based on a strategy of capping d-glucosamine moiety at the C-terminus and fluorinated benzyl group at the N-terminus. From a systematic study on chemical structures, we discovered that the glucosamine-based supramolecular hydrogel [pentafluorobenzyl (PFB)-F-Glu] self-assembled with one-dimensional nanotubular structures at physiological pH. The self-assembly of a newly discovered PFB-F-Glu motif is attributed to the synergistic effect of π-π stacking and extensive intermolecular hydrogen bonding network in aqueous medium. Notably, PFB-F-Glu nanotubes are proven to be nontoxic to human mesenchymal stem cells (hMSCs) and have been shown to enhance hMSC proliferation while maintaining their pluripotency. Retaining of pluripotency capabilities provides potentially unlimited source of undifferentiated cells for the treatment of future cell therapies. Furthermore, hMSCs cultured on PFB-F-Glu are able to secrete paracrine factors that downregulate profibrotic gene expression in lipopolysaccharide-treated human skin fibroblasts, which demonstrates that PFB-F-Glu nanotubes have the potential to be used for wound healing applications. Overall, this article addresses the importance of chemical design to generate supramolecular biomaterials for stem cell therapy.

  5. Home-based Constraint Induced Movement Therapy Poststroke

    Directory of Open Access Journals (Sweden)

    Stephen Isbel HScD

    2014-10-01

    Full Text Available Background: This study examined the efficacy of a home-based Constraint Induced Movement Therapy (CI Therapy protocol with eight poststroke survivors. Method: Eight ABA, single case experiments were conducted in the homes of poststroke survivors. The intervention comprised restraint of the intact upper limb in a mitt for 21 days combined with a home-based and self-directed daily activity regime. Motor changes were measured using The Wolf Motor Function Test (WMFT and the Motor Activity Log (MAL. Results: Grouped results showed statistically and clinically significant differences on the WMFT (WMFT [timed items]: Mean 7.28 seconds, SEM 1.41, 95% CI 4.40 – 10.18, p = 0.000; WMFT (Functional Ability: z = -4.63, p = 0.000. Seven out of the eight participants exceeded the minimal detectable change on both subscales of the MAL. Conclusion: This study offers positive preliminary data regarding the feasibility of a home-based CI Therapy protocol. This requires further study through an appropriately powered control trial.

  6. A ORACLE-based system for data collection, storage and analysis of main equipment load factors in NPPs and TPPs

    International Nuclear Information System (INIS)

    Ivanova, L.

    1993-01-01

    This data base is developed by the National Electricity Company, Sofia (BG) as an aid to supervision, analysis and administration decision making in a variety of operational situations in NPPs and TPPs. As major indicators of the equipment condition the following primary data are stored: steam or electricity production per month; operation hours per month; equipment stand-by outages; planned outages; unplanned permitted maintenance outages; unplanned emergency maintenance outages; number of outages of the unit per month. These data cover the period from the putting of the corresponding equipment into operation till the present moment, i.e. or about 32 years. The data up to 1990 are annual and for the last three years - monthly. Based on these primary data, the following quantities are calculated: average capacity; average load factors; operation time factors - total and accounting for the planned and the permitted unplanned outages; unpermitted outages factors - total and accounting for the planned and the permitted outages. All the factors are calculated on user's request for a chosen time period, by summing up correspondingly the major indicators (production, operation hours and various outages) for the given period. The system operates on an IBM 4341 under VM/SP and DB ORACLE V.5. The input is entered directly from the TPP and NPP by telex lines from PCs, operating also as telex machines, into the mainframe of Energokibernetika Ltd. They are available to all authorised users from local terminals or PCs, connected to the computer by synchronous or asynchronous lines. A system for data transmission to remote users along commutated telephone lines is also developed. (R. Ts.)

  7. A Fault Diagnosis Model of Surface to Air Missile Equipment Based on Wavelet Transformation and Support Vector Machine

    Directory of Open Access Journals (Sweden)

    Zhheng Ni

    2016-01-01

    Full Text Available At present, the fault signals of surface to air missile equipment are hard to collect and the accuracy of fault diagnosis is very low. To solve the above problems, based on the superiority of wavelet transformation on processing non-stationary signals and the advantage of SVM on pattern classification, this paper proposes a fault diagnosis model and takes the typical analog circuit diagnosis of one power distribution system as an example to verify the fault diagnosis model based on Wavelet Transformation and SVM. The simulation results show that the model is able to achieve fault diagnosis based on a small amount of training samples, which improves the accuracy of fault diagnosis.

  8. Microcomputer-based equipment-control and data-acquisition system for fission-reactor reactivity-worth measurements

    International Nuclear Information System (INIS)

    McDowell, W.P.; Bucher, R.G.

    1980-01-01

    Material reactivity-worth measurements are one of the major classes of experiments conducted on the Zero Power research reactors (ZPR) at Argonne National Laboratory. These measurements require the monitoring of the position of a servo control element as a sample material is positioned at various locations in a critical reactor configuration. In order to guarantee operational reliability and increase experimental flexibility for these measurements, the obsolete hardware-based control unit has been replaced with a microcomputer based equipment control and data acquisition system. This system is based on an S-100 bus, dual floppy disk computer with custom built cards to interface with the experimental system. To measure reactivity worths, the system accurately positions samples in the reactor core and acquires data on the position of the servo control element. The data are then analyzed to determine statistical adequacy. The paper covers both the hardware and software aspects of the design

  9. Microcomputer-based equipment-control and data-acquisition system for fission-reactor reactivity-worth measurements

    Energy Technology Data Exchange (ETDEWEB)

    McDowell, W.P.; Bucher, R.G.

    1980-01-01

    Material reactivity-worth measurements are one of the major classes of experiments conducted on the Zero Power research reactors (ZPR) at Argonne National Laboratory. These measurements require the monitoring of the position of a servo control element as a sample material is positioned at various locations in a critical reactor configuration. In order to guarantee operational reliability and increase experimental flexibility for these measurements, the obsolete hardware-based control unit has been replaced with a microcomputer based equipment control and data acquisition system. This system is based on an S-100 bus, dual floppy disk computer with custom built cards to interface with the experimental system. To measure reactivity worths, the system accurately positions samples in the reactor core and acquires data on the position of the servo control element. The data are then analyzed to determine statistical adequacy. The paper covers both the hardware and software aspects of the design.

  10. Developing Home-Based Virtual Reality Therapy Interventions.

    Science.gov (United States)

    Lin, Janice; Kelleher, Caitlin L; Engsberg, Jack R

    2013-02-01

    Stroke is one of the leading causes of serious long-term disability. However, home exercise programs given at rehabilitation often lack in motivational aspects. The purposes of this pilot study were (1) create individualized virtual reality (VR) games and (2) determine the effectiveness of VR games for improving movement in upper extremities in a 6-week home therapy intervention for persons with stroke. Participants were two individuals with upper extremity hemiparesis following a stroke. VR games were created using the Looking Glass programming language and modified based on personal interests, goals, and abilities. Participants were asked to play 1 hour each day for 6 weeks. Assessments measured upper extremity movement (range of motion and Action Research Arm Test [ARAT]) and performance in functional skills (Canadian Occupational Performance Measure [COPM] and Motor Activity Log [MAL]). Three VR games were created by a supervised occupational therapist student. The participants played approximately four to six times a week and performed over 100 repetitions of movements each day. Participants showed improvement in upper extremity movement and participation in functional tasks based on results from the COPM, ARAT, and MAL. Further development in the programming environment is needed to be plausible in a rehabilitation setting. Suggestions include graded-level support and continuation of creating a natural programming language, which will increase the ability to use the program in a rehabilitation setting. However, the VR games were shown to be effective as a home therapy intervention for persons with stroke. VR has the potential to advance therapy services by creating a more motivating home-based therapy service.

  11. Electricity Breakdown Management for Sarawak Energy: Use of Condition-Based Equipment for Detection of Defective Insulator

    Science.gov (United States)

    Tan, J. K.; Abas, N.

    2017-07-01

    Managing electricity breakdown is vital since an outage causes economic losses for customers and the utility companies. However, electricity breakdown is unavoidable due to some internal or external factors beyond our control. Electricity breakdown on overhead lines tend occur more frequently because it is prone to external disturbances such as animal, overgrown vegetation and defective pole top accessories. In Sarawak Energy Berhad (SEB), majority of the network are composed of overhead lines and hence, is more prone to failure. Conventional method of equipment inspection and fault finding are not effective to quickly identify the root cause of failure. SEB has engaged the use of corona discharge camera as condition-based monitoring equipment to carry out condition based inspection on the line in order to diagnose the condition of the lines prior to failure. Experimental testing has been carried out to determine the correlation between the corona discharge count and the level of defect on line insulator. The result shall be tabulated and will be used as reference for future scanning and diagnostic on any defect on the lines.

  12. A Novel Short-Term Maintenance Strategy for Power Transmission and Transformation Equipment Based on Risk-Cost-Analysis

    Directory of Open Access Journals (Sweden)

    Hang Yang

    2017-11-01

    Full Text Available Current studies on preventive condition-based maintenance of power transmission and transformation equipment mainly focus on mid-term or long-term maintenance, and cannot meet the requirements of short-term especially temporary maintenance. In order to solve the defects of the present preventive maintenance strategies, according to the engineering application and based on risk-cost analysis, a short-term maintenance strategy is proposed in this manuscript. For the equipment working in bad health condition, its active maintenance costs and operation risk costs are evaluated, respectively. Then the latest maintenance time is calculated in accordance with the principle that its operation risk costs are no higher than active maintenance costs. Utilizing the latest maintenance time, the best maintenance time is calculated by setting the maximum relative earnings of postponing maintenance as the target, which provides the operation staffs with comprehensive maintenance-decision support. In the end, different cases on the IEEE 24-bus system are simulated. The effectiveness and advantages of the proposed strategy are demonstrated by the simulation results.

  13. Mindfulness-based cognitive therapy for depression: trends and developments

    Directory of Open Access Journals (Sweden)

    MacKenzie MB

    2016-05-01

    Full Text Available Meagan B MacKenzie,1 Nancy L Kocovski21Department of Psychology, Ryerson University, Toronto, ON, Canada; 2Department of Psychology, Wilfrid Laurier University, Waterloo, ON, CanadaAbstract: Mindfulness-based cognitive therapy (MBCT was developed as a psychological intervention for individuals at risk of depressive relapse. Possible mechanisms of change for this intervention are in line with its theoretical underpinnings, and include increases in mindfulness and/or decreases in negative repetitive thoughts. This review provides an overview of current trends in MBCT research, including efficacy and questions regarding the specific effects of MBCT in light of recent comparisons with structurally equivalent control conditions, mechanisms of change, and moderators of treatment outcome. In addition, future directions are discussed, such as challenges with training an adequate number of therapists and disseminating this therapy.Keywords: MBCT, efficacy, mechanisms of change, dissemination, moderators

  14. Oligonucleotide-based theranostic nanoparticles in cancer therapy

    Science.gov (United States)

    Shahbazi, Reza; Ozpolat, Bulent; Ulubayram, Kezban

    2016-01-01

    Theranostic approaches, combining the functionality of both therapy and imaging, have shown potential in cancer nanomedicine. Oligonucleotides such as small interfering RNA and microRNA, which are powerful therapeutic agents, have been effectively employed in theranostic systems against various cancers. Nanoparticles are used to deliver oligonucleotides into tumors by passive or active targeting while protecting the oligonucleotides from nucleases in the extracellular environment. The use of quantum dots, iron oxide nanoparticles and gold nanoparticles and tagging with contrast agents, like fluorescent dyes, optical or magnetic agents and various radioisotopes, has facilitated early detection of tumors and evaluation of therapeutic efficacy. In this article, we review the advantages of theranostic applications in cancer therapy and imaging, with special attention to oligonucleotide-based therapeutics. PMID:27102380

  15. GPU-based high-performance computing for radiation therapy

    International Nuclear Information System (INIS)

    Jia, Xun; Jiang, Steve B; Ziegenhein, Peter

    2014-01-01

    Recent developments in radiotherapy therapy demand high computation powers to solve challenging problems in a timely fashion in a clinical environment. The graphics processing unit (GPU), as an emerging high-performance computing platform, has been introduced to radiotherapy. It is particularly attractive due to its high computational power, small size, and low cost for facility deployment and maintenance. Over the past few years, GPU-based high-performance computing in radiotherapy has experienced rapid developments. A tremendous amount of study has been conducted, in which large acceleration factors compared with the conventional CPU platform have been observed. In this paper, we will first give a brief introduction to the GPU hardware structure and programming model. We will then review the current applications of GPU in major imaging-related and therapy-related problems encountered in radiotherapy. A comparison of GPU with other platforms will also be presented. (topical review)

  16. Diketopyrrolopyrrole-based carbon dots for photodynamic therapy.

    Science.gov (United States)

    He, Haozhe; Zheng, Xiaohua; Liu, Shi; Zheng, Min; Xie, Zhigang; Wang, Yong; Yu, Meng; Shuai, Xintao

    2018-06-01

    The development of a simple and straightforward strategy to synthesize multifunctional carbon dots for photodynamic therapy (PDT) has been an emerging focus. In this work, diketopyrrolopyrrole-based fluorescent carbon dots (DPP CDs) were designed and synthesized through a facile one-pot hydrothermal method by using diketopyrrolopyrrole (DPP) and chitosan (CTS) as raw materials. DPP CDs not only maintained the ability of DPP to generate singlet oxygen (1O2) but also have excellent hydrophilic properties and outstanding biocompatibility. In vitro and in vivo experiments demonstrated that DPP CDs greatly inhibited the growth of tumor cells under laser irradiation (540 nm). This study highlights the potential of the rational design of CDs for efficient cancer therapy.

  17. Evidence - based medicine/practice in sports physical therapy.

    Science.gov (United States)

    Manske, Robert C; Lehecka, B J

    2012-10-01

    A push for the use of evidence-based medicine and evidence-based practice patterns has permeated most health care disciplines. The use of evidence-based practice in sports physical therapy may improve health care quality, reduce medical errors, help balance known benefits and risks, challenge views based on beliefs rather than evidence, and help to integrate patient preferences into decision-making. In this era of health care utilization sports physical therapists are expected to integrate clinical experience with conscientious, explicit, and judicious use of research evidence in order to make clearly informed decisions in order to help maximize and optimize patient well-being. One of the more common reasons for not using evidence in clinical practice is the perceived lack of skills and knowledge when searching for or appraising research. This clinical commentary was developed to educate the readership on what constitutes evidence-based practice, and strategies used to seek evidence in the daily clinical practice of sports physical therapy.

  18. Evidence-based therapy for sleep disorders in neurodegenerative diseases

    Directory of Open Access Journals (Sweden)

    LIU Ling

    2013-08-01

    Full Text Available Objective To evaluate the effectiveness of the treatments for sleep disorders in neurodegenerative diseases so as to provide the best therapeutic regimens for the evidence-based treatment. Methods Search PubMed, MEDLINE, Cochrane Library, Wanfang Data and China National Knowledge Infrastructure (CNKI databases with "sleep disorder or sleep disturbance", "neurodegenerative diseases", "Parkinson's disease or PD", "Alzheimer's disease or AD", "multiple system atrophy or MSA" as retrieval words. The quality of the articles were evaluated with Jadad Scale. Results A total of 35 articles, including 2 systematic reviews, 5 randomized controlled trials, 13 clinical controlled trials, 13 case series and 2 epidemiological investigation studies were included for evaluation, 13 of which were high grade and 22 were low grade articles. Clinical evidences showed that: 1 advice on sleep hygiene, careful use of dopaminergic drugs and hypnotic sedative agents should be considered for PD. Bright light therapy (BLT may improve circadian rhythm sleep disorders and clonazepam may be effective for rapid eye movement sleep behavior disorder (RBD. However, to date, very few controlled studies are available to make a recommendation for the management of sleep disorders in PD; 2 treatments for sleep disorders in AD include drug therapy (e.g. melatonin, acetylcholinesterase inhibitors, antipsychotic drugs, antidepressants and non-drug therapy (e.g. BLT, behavior therapy, but very limited evidence shows the effectiveness of these treatments; 3 the first line treatment for sleep-related breathing disorder in MSA is nasal continuous positive airway pressure (nCPAP, and clonazepam is effective for RBD in MSA; 4 there is rare evidence related to the treatment of sleep disorders in dementia with Lewy body (DLB and amyotrophic lateral sclerosis (ALS. Conclusion Evidence-based medicine can provide the best clinical evidence on sleep disorders' treatment in neurodegenerative

  19. Model-based sensor-augmented pump therapy.

    Science.gov (United States)

    Grosman, Benyamin; Voskanyan, Gayane; Loutseiko, Mikhail; Roy, Anirban; Mehta, Aloke; Kurtz, Natalie; Parikh, Neha; Kaufman, Francine R; Mastrototaro, John J; Keenan, Barry

    2013-03-01

    In insulin pump therapy, optimization of bolus and basal insulin dose settings is a challenge. We introduce a new algorithm that provides individualized basal rates and new carbohydrate ratio and correction factor recommendations. The algorithm utilizes a mathematical model of blood glucose (BG) as a function of carbohydrate intake and delivered insulin, which includes individualized parameters derived from sensor BG and insulin delivery data downloaded from a patient's pump. A mathematical model of BG as a function of carbohydrate intake and delivered insulin was developed. The model includes fixed parameters and several individualized parameters derived from the subject's BG measurements and pump data. Performance of the new algorithm was assessed using n = 4 diabetic canine experiments over a 32 h duration. In addition, 10 in silico adults from the University of Virginia/Padova type 1 diabetes mellitus metabolic simulator were tested. The percentage of time in glucose range 80-180 mg/dl was 86%, 85%, 61%, and 30% using model-based therapy and [78%, 100%] (brackets denote multiple experiments conducted under the same therapy and animal model), [75%, 67%], 47%, and 86% for the control experiments for dogs 1 to 4, respectively. The BG measurements obtained in the simulation using our individualized algorithm were in 61-231 mg/dl min-max envelope, whereas use of the simulator's default treatment resulted in BG measurements 90-210 mg/dl min-max envelope. The study results demonstrate the potential of this method, which could serve as a platform for improving, facilitating, and standardizing insulin pump therapy based on a single download of data. © 2013 Diabetes Technology Society.

  20. Ethical and Safety Issues of Stem Cell-Based Therapy.

    Science.gov (United States)

    Volarevic, Vladislav; Markovic, Bojana Simovic; Gazdic, Marina; Volarevic, Ana; Jovicic, Nemanja; Arsenijevic, Nebojsa; Armstrong, Lyle; Djonov, Valentin; Lako, Majlinda; Stojkovic, Miodrag

    2018-01-01

    Results obtained from completed and on-going clinical studies indicate huge therapeutic potential of stem cell-based therapy in the treatment of degenerative, autoimmune and genetic disorders. However, clinical application of stem cells raises numerous ethical and safety concerns. In this review, we provide an overview of the most important ethical issues in stem cell therapy, as a contribution to the controversial debate about their clinical usage in regenerative and transplantation medicine. We describe ethical challenges regarding human embryonic stem cell (hESC) research, emphasizing that ethical dilemma involving the destruction of a human embryo is a major factor that may have limited the development of hESC-based clinical therapies. With previous derivation of induced pluripotent stem cells (iPSCs) this problem has been overcome, however current perspectives regarding clinical translation of iPSCs still remain. Unlimited differentiation potential of iPSCs which can be used in human reproductive cloning, as a risk for generation of genetically engineered human embryos and human-animal chimeras, is major ethical issue, while undesired differentiation and malignant transformation are major safety issues. Although clinical application of mesenchymal stem cells (MSCs) has shown beneficial effects in the therapy of autoimmune and chronic inflammatory diseases, the ability to promote tumor growth and metastasis and overestimated therapeutic potential of MSCs still provide concerns for the field of regenerative medicine. This review offers stem cell scientists, clinicians and patient's useful information and could be used as a starting point for more in-depth analysis of ethical and safety issues related to clinical application of stem cells.

  1. Study on intelligence fault diagnosis method for nuclear power plant equipment based on rough set and fuzzy neural network

    International Nuclear Information System (INIS)

    Liu Yongkuo; Xia Hong; Xie Chunli; Chen Zhihui; Chen Hongxia

    2007-01-01

    Rough set theory and fuzzy neural network are combined, to take full advantages of the two of them. Based on the reduction technology to knowledge of Rough set method, and by drawing the simple rule from a large number of initial data, the fuzzy neural network was set up, which was with better topological structure, improved study speed, accurate judgment, strong fault-tolerant ability, and more practical. In order to test the validity of the method, the inverted U-tubes break accident of Steam Generator and etc are used as examples, and many simulation experiments are performed. The test result shows that it is feasible to incorporate the fault intelligence diagnosis method based on rough set and fuzzy neural network in the nuclear power plant equipment, and the method is simple and convenience, with small calculation amount and reliable result. (authors)

  2. Radio frequency electromagnetic field compliance assessment of multi-band and MIMO equipped radio base stations.

    Science.gov (United States)

    Thors, Björn; Thielens, Arno; Fridén, Jonas; Colombi, Davide; Törnevik, Christer; Vermeeren, Günter; Martens, Luc; Joseph, Wout

    2014-05-01

    In this paper, different methods for practical numerical radio frequency exposure compliance assessments of radio base station products were investigated. Both multi-band base station antennas and antennas designed for multiple input multiple output (MIMO) transmission schemes were considered. For the multi-band case, various standardized assessment methods were evaluated in terms of resulting compliance distance with respect to the reference levels and basic restrictions of the International Commission on Non-Ionizing Radiation Protection. Both single frequency and multiple frequency (cumulative) compliance distances were determined using numerical simulations for a mobile communication base station antenna transmitting in four frequency bands between 800 and 2600 MHz. The assessments were conducted in terms of root-mean-squared electromagnetic fields, whole-body averaged specific absorption rate (SAR) and peak 10 g averaged SAR. In general, assessments based on peak field strengths were found to be less computationally intensive, but lead to larger compliance distances than spatial averaging of electromagnetic fields used in combination with localized SAR assessments. For adult exposure, the results indicated that even shorter compliance distances were obtained by using assessments based on localized and whole-body SAR. Numerical simulations, using base station products employing MIMO transmission schemes, were performed as well and were in agreement with reference measurements. The applicability of various field combination methods for correlated exposure was investigated, and best estimate methods were proposed. Our results showed that field combining methods generally considered as conservative could be used to efficiently assess compliance boundary dimensions of single- and dual-polarized multicolumn base station antennas with only minor increases in compliance distances. © 2014 Wiley Periodicals, Inc.

  3. Vibration-based Energy Harvesting Systems Characterization Using Automated Electronic Equipment

    Directory of Open Access Journals (Sweden)

    Ioannis KOSMADAKIS

    2015-04-01

    Full Text Available A measurement bench has been developed to fully automate the procedure for the characterization of a vibration-based energy scavenging system. The measurement system is capable of monitoring all important characteristics of a vibration harvesting system (input and output voltage, current, and other parameters, frequency and acceleration values, etc.. It is composed of a PC, typical digital measuring instruments (oscilloscope, waveform generator, etc., certain sensors and actuators, along with a microcontroller based automation module. The automation of the procedure and the manipulation of the acquired data are performed by LabVIEW software. Typical measurements of a system consisting of a vibrating source, a vibration transducer and an active rectifier are presented.

  4. Simple microprocessor-based system for upgrading existing X-ray equipment for analysis

    International Nuclear Information System (INIS)

    Souza, A.M. de

    1986-01-01

    A data acquisition and processing device appropriate for X-ray analysis and goniometer control was built. A conventional Z-80 based systems was used, and the interfacing architeture and the applicable soft-ware are described. The advantages and new possibilities of the automated instrument as compared to previous ones are listed. It is shown that the X-ray diffraction and fluorescence techniques can take advantage of the automation using existing instruments. (Author) [pt

  5. NN-Es Fault Diagnosis Method in Nuclear Power Equipment Based on Concept Lattice

    International Nuclear Information System (INIS)

    Liu Yongkuo; Xie Chunli; Xia Hong

    2010-01-01

    In order to improve the fault diagnosis accuracy of nuclear power plant,neural network and expert systems were combined to give full play to their advantages. In this paper, the concept lattice was applied to get the object properties, extracting the core attributes, dispensable attributes and relative necessary attributes from a large number raw data of fault symptoms.Based on these attributes, neural networks with different levels of importance were designed to improve the learning speed and diagnosis accuracy, and the diagnosis results of the neural networks were verified by using rule-based reasoning expert system. To verify the accuracy of this method, some simulation experiments about the typical faults of nuclear power plant were conducted. And the simulation results show that it is feasible to diagnose nuclear power plant faults with the confederation diagnosis methods combined the neural networks based on the concept lattice theory and expert system, with the distinctive features such as the efficiency of neural network learning, less calculation and reliability of diagnosis results and so on. (authors)

  6. Mirror neuron system based therapy for emotional disorders.

    Science.gov (United States)

    Yuan, Ti-Fei; Hoff, Robert

    2008-11-01

    Mirror neuron system (MNS) represents one of the most important discoveries in the area of neuropsychology of past decades. More than 500 papers have been published in this area (PubMed), and the major functions of MNS include action understanding, imitation, empathy, all of which are critical for an individual to be social. Recent studies suggested that MNS can modulate emotion states possibly through the empathy mechanism. Here we propose that MNS-based therapies provide a non-invasive approach in treatments to emotional disorders that were observed in autism patients, post-stroke patients with depression as well as other mood dysregulation conditions.

  7. Evaluation of a GEM and CAT-based detector for radiation therapy beam monitoring

    International Nuclear Information System (INIS)

    Brahme, A.; Danielsson, M.; Iacobaeus, C.; Ostling, J.; Peskov, V.; Wallmark, M.

    2000-01-01

    We are developing a radiation therapy beam monitor for the Karolinska Institute. This monitor will consist of two consecutive detectors confined in one gas chamber: a 'keV-photon detector', which will allow diagnostic quality visualization of the patient, and a 'MeV-photon detector', that will measure the absolute intensity of the therapy beam and its position with respect to the patient. Both detectors are based on highly radiation resistant gas and solid photon to electron converters, combined with GEMs and a CAT as amplification structures. We have performed systematic studies of the high-rate characteristics of the GEM and the CAT, as well as tested the electron transfer through these electron multipliers and various types of converters. The tests show that the GEM and the CAT satisfy all requirements for the beam monitoring system. As a result of these studies we successfully developed and tested a full section of the beam monitor equipped with a MeV-photon converter placed between the GEM and the CAT

  8. The choice of equipment mix and parameters for HTGR-based nuclear cogeneration plants

    Energy Technology Data Exchange (ETDEWEB)

    Malevski, A L; Stoliarevski, A Ya; Vladimirov, V T; Larin, E A; Lesnykh, V V; Naumov, Yu V; Fedotov, I L

    1990-07-01

    Improvement of heat and electricity supply systems based on cogeneration is one of the high-priority problems in energy development of the USSR. Fossil fuel consumption for heat supply exceeds now its use for electricity production and amounts to about 30% of the total demands. District heating provides about 80 million t.c.e. of energy resources conserved annually and meets about 50% of heat consumption of the country, including about 30% due to cogeneration. The share of natural gas and liquid fuel in the fuel consumption for district heating is about 70%. The analysis of heat consumption dynamics in individual regions and industrial-urban agglomerations shows the necessity of constructing cogeneration plants with the total capacity of about 60 million kW till the year 2000. However, their construction causes some serious problems. The most important of them are provision of environmentally clean fuels for cogeneration plants and provision of clear air. The limited reserves of oil and natural gas and the growing expenditures on their production require more intensive introduction of nuclear energy in the national energy balance. Possible use of nuclear energy based on light-water reactors for substitution of deficient hydrocarbon fuels is limited by the physical, technical and economic factors and requirements of safety. Further development of nuclear energy in the USSR can be realized on a new technological base with construction of domestic reactors of increased and ultimate safety. The most promising reactors under design are high-temperature gas-cooled reactors (HTGR) of low and medium capacity with the intrinsic property of safety. HTGR of low (about 200-250 MW(th) in a steel vessel), medium (about 500 MW(th) in a steel-concrete vessel) and high (about 1000-2500 MW(th) in a prestressed concrete vessel) are now designed and studied in the country. At outlet helium temperature of 920-1020 K it is possible to create steam turbine installations producing both

  9. The choice of equipment mix and parameters for HTGR-based nuclear cogeneration plants

    International Nuclear Information System (INIS)

    Malevski, A.L.; Stoliarevski, A.Ya.; Vladimirov, V.T.; Larin, E.A.; Lesnykh, V.V.; Naumov, Yu.V.; Fedotov, I.L.

    1990-01-01

    Improvement of heat and electricity supply systems based on cogeneration is one of the high-priority problems in energy development of the USSR. Fossil fuel consumption for heat supply exceeds now its use for electricity production and amounts to about 30% of the total demands. District heating provides about 80 million t.c.e. of energy resources conserved annually and meets about 50% of heat consumption of the country, including about 30% due to cogeneration. The share of natural gas and liquid fuel in the fuel consumption for district heating is about 70%. The analysis of heat consumption dynamics in individual regions and industrial-urban agglomerations shows the necessity of constructing cogeneration plants with the total capacity of about 60 million kW till the year 2000. However, their construction causes some serious problems. The most important of them are provision of environmentally clean fuels for cogeneration plants and provision of clear air. The limited reserves of oil and natural gas and the growing expenditures on their production require more intensive introduction of nuclear energy in the national energy balance. Possible use of nuclear energy based on light-water reactors for substitution of deficient hydrocarbon fuels is limited by the physical, technical and economic factors and requirements of safety. Further development of nuclear energy in the USSR can be realized on a new technological base with construction of domestic reactors of increased and ultimate safety. The most promising reactors under design are high-temperature gas-cooled reactors (HTGR) of low and medium capacity with the intrinsic property of safety. HTGR of low (about 200-250 MW(th) in a steel vessel), medium (about 500 MW(th) in a steel-concrete vessel) and high (about 1000-2500 MW(th) in a prestressed concrete vessel) are now designed and studied in the country. At outlet helium temperature of 920-1020 K it is possible to create steam turbine installations producing both

  10. Production Decision Based on Discounted Price and Delivery Frequency for Garment Original Equipment Manufacturer with Constrained Capacity

    Institute of Scientific and Technical Information of China (English)

    HUO Yanfang; GU Yajie; HAN Lin; WANG Xize

    2017-01-01

    Original equipment manufacturers (OEM) have never been so important and powerful as it is today in garment manufacturing industry.The OEM supplier's production decisions always have a great impact on the market performance and the profits of a garment brand manufacturer.With constrained capacity and multiply buyers,how to make reasonable production decisions is an urgent problem for OEM suppliers.A price discount model with a single OEM supplier and two buyers is proposed to deal with the problem.Based on this model,the OEM supplier could satisfy buyers' demands and guarantee their profits as well through adjusting price and delivery frequency.A numerical example validates the validity of the model.

  11. Analysis of parameters for technological equipment of parallel kinematics based on rods of variable length for processing accuracy assurance

    Science.gov (United States)

    Koltsov, A. G.; Shamutdinov, A. H.; Blokhin, D. A.; Krivonos, E. V.

    2018-01-01

    A new classification of parallel kinematics mechanisms on symmetry coefficient, being proportional to mechanism stiffness and accuracy of the processing product using the technological equipment under study, is proposed. A new version of the Stewart platform with a high symmetry coefficient is presented for analysis. The workspace of the mechanism under study is described, this space being a complex solid figure. The workspace end points are reached by the center of the mobile platform which moves in parallel related to the base plate. Parameters affecting the processing accuracy, namely the static and dynamic stiffness, natural vibration frequencies are determined. The capability assessment of the mechanism operation under various loads, taking into account resonance phenomena at different points of the workspace, was conducted. The study proved that stiffness and therefore, processing accuracy with the use of the above mentioned mechanisms are comparable with the stiffness and accuracy of medium-sized series-produced machines.

  12. Safety assessment on the key equipment of coal gasification based on SDG-HAZOP method

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, B.; Xu, X.; Ma, X.; Wu, C. [Beijing University of Chemical Technology, Beijing (China)

    2008-07-15

    An example of the coal gasification process was introduced after the explanation of the graphical representation method known as the sign directed graph (SDG). The systematic modeling procedure was also introduced. Firstly, the key variables of the whole system were selected. Then the relationship equations were listed. Finally, the SDG-HAZOP (hazard and operability) model was derived after attaching the abnormal causes and adverse consequences. In order to get a credible SDG model, the model was checked by technicians in the factory. Based on computer-aided analysis, this model can express almost all the dangerous features of the gasification process. It can also reveal the mechanisms of danger propagation, which may effectively help safety engineers to identify potential hazards. 15 refs., 4 figs., 1 tab.

  13. Pneumatic transport devices based on the ARS equipment set for activation analysis

    International Nuclear Information System (INIS)

    Ivanov, I.V.; Ivanets, V.N.; Rogachev, V.M.; Zakharov, E.A.

    1978-01-01

    The AGIDEL and ARS-28G facilities manufactured on the basis of a set of standardized and aggregated products for activation analysis are described. The AGIDEL is designed for automatic activation analysis of relatively homogeneous samples from oil boreholes. The ARS-28G is designed for transporting the test samples during activation analysis, using a fast-neutron generator. Structurally, the ARS-28 is based on a pneumatic transportation system with two independenhat transport cnnels and a two-channel rotating irradiation unit. The analyzed samples are transported in polyethylene containers, which are moved by compressed air. The facility has been successfully tested and is used in an automated system for multielement activation analysis

  14. Piezoresistor-equipped fluorescence-based cantilever probe for near-field scanning.

    Science.gov (United States)

    Kan, Tetsuo; Matsumoto, Kiyoshi; Shimoyama, Isao

    2007-08-01

    Scanning near-field optical microscopes (SNOMs) with fluorescence-based probes are promising tools for evaluating the optical characteristics of nanoaperture devices used for biological investigations, and this article reports on the development of a microfabricated fluorescence-based SNOM probe with a piezoresistor. The piezoresistor was built into a two-legged root of a 160-microm-long cantilever. To improve the displacement sensitivity of the cantilever, the piezoresistor's doped area was shallowly formed on the cantilever surface. A fluorescent bead, 500 nm in diameter, was attached to the bottom of the cantilever end as a light-intensity-sensitive material in the visible-light range. The surface of the scanned sample was simply detected by the probe's end being displaced by contact with the sample. Measuring displacements piezoresistively is advantageous because it eliminates the noise arising from the use of the optical-lever method and is free of any disturbance in the absorption or the emission spectrum of the fluorescent material at the probe tip. The displacement sensitivity was estimated to be 6.1 x 10(-6) nm(-1), and the minimum measurable displacement was small enough for near-field measurement. This probe enabled clear scanning images of the light field near a 300 x 300 nm(2) aperture to be obtained in the near-field region where the tip-sample distance is much shorter than the light wavelength. This scanning result indicates that the piezoresistive way of tip-sample distance regulation is effective for characterizing nanoaperture optical devices.

  15. Parasite-based malaria diagnosis: are health systems in Uganda equipped enough to implement the policy?

    Science.gov (United States)

    Kyabayinze, Daniel J; Achan, Jane; Nakanjako, Damalie; Mpeka, Betty; Mawejje, Henry; Mugizi, Rukaaka; Kalyango, Joan N; D'Alessandro, Umberto; Talisuna, Ambrose; Jean-Pierre, Van geertruyden

    2012-08-24

    Malaria case management is a key strategy for malaria control. Effective coverage of parasite-based malaria diagnosis (PMD) remains limited in malaria endemic countries. This study assessed the health system's capacity to absorb PMD at primary health care facilities in Uganda. In a cross sectional survey, using multi-stage cluster sampling, lower level health facilities (LLHF) in 11 districts in Uganda were assessed for 1) tools, 2) skills, 3) staff and infrastructure, and 4) structures, systems and roles necessary for the implementing of PMD. Tools for PMD (microscopy and/or RDTs) were available at 30 (24%) of the 125 LLHF. All LLHF had patient registers and 15% had functional in-patient facilities. Three months' long stock-out periods were reported for oral and parenteral quinine at 39% and 47% of LLHF respectively. Out of 131 health workers interviewed, 86 (66%) were nursing assistants; 56 (43%) had received on-job training on malaria case management and 47 (36%) had adequate knowledge in malaria case management. Overall, only 18% (131/730) Ministry of Health approved staff positions were filled by qualified personnel and 12% were recruited or transferred within six months preceding the survey. Of 186 patients that received referrals from LLHF, 130(70%) had received pre-referral anti-malarial drugs, none received pre-referral rectal artesunate and 35% had been referred due to poor response to antimalarial drugs. Primary health care facilities had inadequate human and infrastructural capacity to effectively implement universal parasite-based malaria diagnosis. The priority capacity building needs identified were: 1) recruitment and retention of qualified staff, 2) comprehensive training of health workers in fever management, 3) malaria diagnosis quality control systems and 4) strengthening of supply chain, stock management and referral systems.

  16. Information needs assessment of medical equipment offices based on Critical Success Factors (CSF) and Business System Planning (BSP) methods.

    Science.gov (United States)

    Khorrami, F; Ahmadi, M; Alizadeh, A; Roozbeh, N; Mohseni, S

    2015-01-01

    Introduction: Given the ever-increasing importance and value of information, providing the management with a reliable information system, which can facilitate decision-making regarding planning, organization and control, is vitally important. This study aimed to analyze and evaluate the information needs of medical equipment offices. Methods: This descriptive applied cross-sectional study was carried out in 2010. The population of the study included the managers of statistic and medical records at the offices of vice-chancellor for treatment in 39 medical universities in Iran. Data were collected by using structured questioners. With regard to different kinds of designing information systems, sampling was done by two methods, BSP (based on processes of job description) and CSF method (based on critical success factors). The data were analyzed by SPSS-16. Results: Our study showed that 41% of information needs were found to be critical success factors of managers of office. The first priority of managers was "the number of bed and bed occupancy in hospitals". Of 29 identified information needs, 62% were initial information needs of managers (from the viewpoints of managers). Of all, 4% of the information needs were obtained through the form, 14% through both the form and database, 11% through the web site, and 71% had no sources (forms, databases, web site). Conclusion: Since 71% of the information needs of medical equipment offices managers had no information sources, the development of information system in these offices seems to be necessary. Despite the important role of users in designing the information systems (identifying 62% of information needs), other scientific methods is also needed to be utilized in designing the information systems.

  17. Information needs assessment of medical equipment offices based on Critical Success Factors (CSF) and Business System Planning (BSP) methods

    Science.gov (United States)

    Khorrami, F; Ahmadi, M; Alizadeh, A; Roozbeh, N; Mohseni, S

    2015-01-01

    Introduction: Given the ever-increasing importance and value of information, providing the management with a reliable information system, which can facilitate decision-making regarding planning, organization and control, is vitally important. This study aimed to analyze and evaluate the information needs of medical equipment offices. Methods: This descriptive applied cross-sectional study was carried out in 2010. The population of the study included the managers of statistic and medical records at the offices of vice-chancellor for treatment in 39 medical universities in Iran. Data were collected by using structured questioners. With regard to different kinds of designing information systems, sampling was done by two methods, BSP (based on processes of job description) and CSF method (based on critical success factors). The data were analyzed by SPSS-16. Results: Our study showed that 41% of information needs were found to be critical success factors of managers of office. The first priority of managers was “the number of bed and bed occupancy in hospitals”. Of 29 identified information needs, 62% were initial information needs of managers (from the viewpoints of managers). Of all, 4% of the information needs were obtained through the form, 14% through both the form and database, 11% through the web site, and 71% had no sources (forms, databases, web site). Conclusion: Since 71% of the information needs of medical equipment offices managers had no information sources, the development of information system in these offices seems to be necessary. Despite the important role of users in designing the information systems (identifying 62% of information needs), other scientific methods is also needed to be utilized in designing the information systems. PMID:28255389

  18. Moving from virtual reality exposure-based therapy to augmented reality exposure-based therapy: a review.

    Science.gov (United States)

    Baus, Oliver; Bouchard, Stéphane

    2014-01-01

    This paper reviews the move from virtual reality exposure-based therapy to augmented reality exposure-based therapy (ARET). Unlike virtual reality (VR), which entails a complete virtual environment (VE), augmented reality (AR) limits itself to producing certain virtual elements to then merge them into the view of the physical world. Although, the general public may only have become aware of AR in the last few years, AR type applications have been around since beginning of the twentieth century. Since, then, technological developments have enabled an ever increasing level of seamless integration of virtual and physical elements into one view. Like VR, AR allows the exposure to stimuli which, due to various reasons, may not be suitable for real-life scenarios. As such, AR has proven itself to be a medium through which individuals suffering from specific phobia can be exposed "safely" to the object(s) of their fear, without the costs associated with programing complete VEs. Thus, ARET can offer an efficacious alternative to some less advantageous exposure-based therapies. Above and beyond presenting what has been accomplished in ARET, this paper covers some less well-known aspects of the history of AR, raises some ARET related issues, and proposes potential avenues to be followed. These include the type of measures to be used to qualify the user's experience in an augmented reality environment, the exclusion of certain AR-type functionalities from the definition of AR, as well as the potential use of ARET to treat non-small animal phobias, such as social phobia.

  19. Moving from Virtual Reality Exposure-Based Therapy to Augmented Reality Exposure-Based Therapy: A Review

    Science.gov (United States)

    Baus, Oliver; Bouchard, Stéphane

    2014-01-01

    This paper reviews the move from virtual reality exposure-based therapy to augmented reality exposure-based therapy (ARET). Unlike virtual reality (VR), which entails a complete virtual environment (VE), augmented reality (AR) limits itself to producing certain virtual elements to then merge them into the view of the physical world. Although, the general public may only have become aware of AR in the last few years, AR type applications have been around since beginning of the twentieth century. Since, then, technological developments have enabled an ever increasing level of seamless integration of virtual and physical elements into one view. Like VR, AR allows the exposure to stimuli which, due to various reasons, may not be suitable for real-life scenarios. As such, AR has proven itself to be a medium through which individuals suffering from specific phobia can be exposed “safely” to the object(s) of their fear, without the costs associated with programing complete VEs. Thus, ARET can offer an efficacious alternative to some less advantageous exposure-based therapies. Above and beyond presenting what has been accomplished in ARET, this paper covers some less well-known aspects of the history of AR, raises some ARET related issues, and proposes potential avenues to be followed. These include the type of measures to be used to qualify the user’s experience in an augmented reality environment, the exclusion of certain AR-type functionalities from the definition of AR, as well as the potential use of ARET to treat non-small animal phobias, such as social phobia. PMID:24624073

  20. Moving from Virtual Reality Exposure-Based Therapy (VRET to Augmented Reality Exposure-Based Therapy (ARET: A review.

    Directory of Open Access Journals (Sweden)

    Oliver eBaus

    2014-03-01

    Full Text Available This paper reviews the move from virtual reality exposure-based therapy (VRET to augmented reality exposure-based therapy (ARET. Unlike virtual reality (VR, which entails a complete virtual environment (VE, augmented reality (AR limits itself to producing certain virtual elements to then merge them into the view of the physical world. Although the general public may only have become aware of AR in the last few years, AR type applications have been around since beginning of the 20th century. Since, then, technological developments have enabled an ever increasing level of seamless integration of virtual and physical elements into one view. Like VR, AR allows the exposure to stimuli which, due to various reasons, may not be suitable for real-life scenarios. As such, AR has proven itself to be a medium through which individuals suffering from specific phobia can be exposed safely to the object(s of their fear, without the costs associated with programming complete virtual environments. Thus, ARET can offer an efficacious alternative to some less advantageous exposure-based therapies. Above and beyond presenting what has been accomplished in ARET, this paper also raises some ARET related issues, and proposes potential avenues to be followed. These include the definition of an AR related term, the type of measures to be used to qualify the user’s experience in an augmented reality environment (ARE, the development of alternative geospatial referencing systems, as well as the potential use of ARET to treat social phobia. Overall, it may be said that the use of ARET, although promising, is still in its infancy but that, given a continued cooperation between clinical and technical teams, ARET has the potential of going well beyond the treatment of small animal phobia.

  1. Computational Fluid Dynamics (CFD-Based Droplet Size Estimates in Emulsification Equipment

    Directory of Open Access Journals (Sweden)

    Jo Janssen

    2016-12-01

    Full Text Available While academic literature shows steady progress in combining multi-phase computational fluid dynamics (CFD and population balance modelling (PBM of emulsification processes, the computational burden of this approach is still too large for routine use in industry. The challenge, thus, is to link a sufficiently detailed flow analysis to the droplet behavior in a way that is both physically relevant and computationally manageable. In this research article we propose the use of single-phase CFD to map out the local maximum stable droplet diameter within a given device, based on well-known academic droplet break-up studies in quasi-steady 2D linear flows. The results of the latter are represented by analytical correlations for the critical capillary number, which are valid across a wide viscosity ratio range. Additionally, we suggest a parameter to assess how good the assumption of quasi-steady 2D flow is locally. The approach is demonstrated for a common lab-scale rotor-stator device (Ultra-Turrax, IKA-Werke GmbH, Staufen, Germany. It is found to provide useful insights with minimal additional user coding and little increase in computational effort compared to the single-phase CFD simulations of the flow field, as such. Some suggestions for further development are briefly discussed.

  2. Nanotechnology based surface treatments for corrosion protection and deposit control of power plant equipment. Phase 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-05-15

    Nanotechnology can provide possibilities for obtaining new valuable information regarding performance and corrosion protection in power plants. In general the desired performance of the contact surfaces is an easy-to-release effect. This is in order to prolong the time interval between cleaning periods or make the cleaning procedures easier and less expensive. Corrosion protection is also desired in order to extend the life time of various parts in the power plants and thus optimize the energy output and overall efficiency of the plant. Functional sol-gel coating based on nanotechnology is tested in a variety of conditions. Applications of functional sol-gel coatings were performed in the condenser and on seven air preheaters at Fynsvaerket, Odense, with corrosion protection as the main issue. Coatings with easy-to-clean effects were tested in the Flue Gas Desulphurization plant at Nordjyllandsvaerket, Aalborg, with the aim of reducing gipsum deposit. Thermo stabilized coatings were tested on tube bundles between in the passage from the 1st to 2end pass and on the wall between 1st and 2end pass at Amagervaerket, Copenhagen, and in the boiler at Haderslev CHP plant. The objective of this test were reducing deposits and increasing corrosion protection. The tested coatings were commercial available coatings and coatings developed in this project. Visual inspections have been performed of all applications except at Nordjyllandsvaerket. Corrosion assessment has been done at DTU - Mechanical Engineering. The results range from no difference between coated and uncoated areas to some improvements. At Amagervaerket the visual assessment showed in general a positive effect with a sol-gel hybrid system and a commercial system regarding removal of deposits. The visual assessment of the air preheaters at Fynsvaerket indicates reduced deposits on a sol-gel nanocomposite coated air preheater compared to an uncoated air preheater. (Author)

  3. ROENTGEN: case-based reasoning and radiation therapy planning.

    Science.gov (United States)

    Berger, J.

    1992-01-01

    ROENTGEN is a design assistant for radiation therapy planning which uses case-based reasoning, an artificial intelligence technique. It learns both from specific problem-solving experiences and from direct instruction from the user. The first sort of learning is the normal case-based method of storing problem solutions so that they can be reused. The second sort is necessary because ROENTGEN does not, initially, have an internal model of the physics of its problem domain. This dependence on explicit user instruction brings to the forefront representational questions regarding indexing, failure definition, failure explanation and repair. This paper presents the techniques used by ROENTGEN in its knowledge acquisition and design activities. PMID:1482869

  4. Stem Cell-Based Therapies for Ischemic Stroke

    Directory of Open Access Journals (Sweden)

    Lei Hao

    2014-01-01

    Full Text Available In recent years, stem cell-based approaches have attracted more attention from scientists and clinicians due to their possible therapeutical effect on stroke. Animal studies have demonstrated that the beneficial effects of stem cells including embryonic stem cells (ESCs, inducible pluripotent stem cells (iPSCs, neural stem cells (NSCs, and mesenchymal stem cell (MSCs might be due to cell replacement, neuroprotection, endogenous neurogenesis, angiogenesis, and modulation on inflammation and immune response. Although several clinical studies have shown the high efficiency and safety of stem cell in stroke management, mainly MSCs, some issues regarding to cell homing, survival, tracking, safety, and optimal cell transplantation protocol, such as cell dose and time window, should be addressed. Undoubtably, stem cell-based gene therapy represents a novel potential therapeutic strategy for stroke in future.

  5. Proton therapy for tumors of the skull base

    Energy Technology Data Exchange (ETDEWEB)

    Munzenrider, J.E.; Liebsch, N.J. [Dept. of Radiation Oncology, Harvard Univ. Medical School, Boston, MA (United States)

    1999-06-01

    Charged particle beams are ideal for treating skull base and cervical spine tumors: dose can be focused in the target, while achieving significant sparing of the brain, brain stem, cervical cord, and optic nerves and chiasm. For skull base tumors, 10-year local control rates with combined proton-photon therapy are highest for chondrosarcomas, intermediate for male chordomas, and lowest for female chordomas (94%, 65%, and 42%, respectively). For cervical spine tumors, 10-year local control rates are not significantly different for chordomas and chondrosarcomas (54% and 48%, respectively), nor is there any difference in local control between males and females. Observed treatment-related morbidity has been judged acceptable, in view of the major morbidity and mortality which accompany uncontrolled tumor growth. (orig.)

  6. Proton therapy for tumors of the skull base

    International Nuclear Information System (INIS)

    Munzenrider, J.E.; Liebsch, N.J.

    1999-01-01

    Charged particle beams are ideal for treating skull base and cervical spine tumors: dose can be focused in the target, while achieving significant sparing of the brain, brain stem, cervical cord, and optic nerves and chiasm. For skull base tumors, 10-year local control rates with combined proton-photon therapy are highest for chondrosarcomas, intermediate for male chordomas, and lowest for female chordomas (94%, 65%, and 42%, respectively). For cervical spine tumors, 10-year local control rates are not significantly different for chordomas and chondrosarcomas (54% and 48%, respectively), nor is there any difference in local control between males and females. Observed treatment-related morbidity has been judged acceptable, in view of the major morbidity and mortality which accompany uncontrolled tumor growth. (orig.)

  7. Cryopreservation of GABAergic Neuronal Precursors for Cell-Based Therapy.

    Directory of Open Access Journals (Sweden)

    Daniel Rodríguez-Martínez

    Full Text Available Cryopreservation protocols are essential for stem cells storage in order to apply them in the clinic. Here we describe a new standardized cryopreservation protocol for GABAergic neural precursors derived from the medial glanglionic eminence (MGE, a promising source of GABAergic neuronal progenitors for cell therapy against interneuron-related pathologies. We used 10% Me2SO as cryoprotectant and assessed the effects of cell culture amplification and cellular organization, as in toto explants, neurospheres, or individualized cells, on post-thaw cell viability and retrieval. We confirmed that in toto cryopreservation of MGE explants is an optimal preservation system to keep intact the interneuron precursor properties for cell transplantation, together with a high cell viability (>80% and yield (>70%. Post-thaw proliferation and self-renewal of the cryopreserved precursors were tested in vitro. In addition, their migration capacity, acquisition of mature neuronal morphology, and potency to differentiate into multiple interneuron subtypes were also confirmed in vivo after transplantation. The results show that the cryopreserved precursor features remained intact and were similar to those immediately transplanted after their dissection from the MGE. We hope this protocol will facilitate the generation of biobanks to obtain a permanent and reliable source of GABAergic precursors for clinical application in cell-based therapies against interneuronopathies.

  8. Microsponges based novel drug delivery system for augmented arthritis therapy.

    Science.gov (United States)

    Osmani, Riyaz Ali M; Aloorkar, Nagesh H; Ingale, Dipti J; Kulkarni, Parthasarathi K; Hani, Umme; Bhosale, Rohit R; Jayachandra Dev, Dandasi

    2015-10-01

    The motive behind present work was to formulate and evaluate gel containing microsponges of diclofenac diethylamine to provide prolonged release for proficient arthritis therapy. Quasi-emulsion solvent diffusion method was implied using Eudragit RS-100 and microsponges with varied drug-polymer ratios were prepared. For the sake of optimization, diverse factors affecting microparticles physical properties were too investigated. Microsponges were characterized by SEM, DSC, FT-IR, XRPD and particle size analysis, and evaluated for morphology, drug loading, in vitro drug release and ex vivo diffusion as well. There were no chemical interactions between drug and polymers used as revealed by compatibility studies outcomes. The drug polymer ratio reflected notable effect on drug content, encapsulation efficiency and particle size. SEM results revealed spherical microsponges with porous surface, and had 7.21 μm mean particle size. The microsponges were then incorporated in gel; which exhibited viscous modulus along with pseudoplastic behavior. In vitro drug release results depicted that microsponges with 1:2 drug-polymer ratio were more efficient to give extended drug release of 75.88% at the end of 8 h; while conventional formulation get exhausted incredibly earlier by releasing 81.11% drug at the end of 4 h only. Thus the formulated microsponge-based gel of diclofenac diethylamine would be a promising alternative to conventional therapy for safer and efficient treatment of arthritis and musculoskeletal disorders.

  9. Clinical advances of nanocarrier-based cancer therapy and diagnostics.

    Science.gov (United States)

    Luque-Michel, Edurne; Imbuluzqueta, Edurne; Sebastián, Víctor; Blanco-Prieto, María J

    2017-01-01

    Cancer is a leading cause of death worldwide and efficient new strategies are urgently needed to combat its high mortality and morbidity statistics. Fortunately, over the years, nanotechnology has evolved as a frontrunner in the areas of imaging, diagnostics and therapy, giving the possibility of monitoring, evaluating and individualizing cancer treatments in real-time. Areas covered: Polymer-based nanocarriers have been extensively studied to maximize cancer treatment efficacy and minimize the adverse effects of standard therapeutics. Regarding diagnosis, nanomaterials like quantum dots, iron oxide nanoparticles or gold nanoparticles have been developed to provide rapid, sensitive detection of cancer and, therefore, facilitate early treatment and monitoring of the disease. Therefore, multifunctional nanosystems with both imaging and therapy functionalities bring us a step closer to delivering precision/personalized medicine in the cancer setting. Expert opinion: There are multiple barriers for these new nanosystems to enter the clinic, but it is expected that in the near future, nanocarriers, together with new 'targeted drugs', could replace our current treatments and cancer could become a nonfatal disease with good recovery rates. Joint efforts between scientists, clinicians, the pharmaceutical industry and legislative bodies are needed to bring to fruition the application of nanosystems in the clinical management of cancer.

  10. Conventional and novel stem cell based therapies for androgenic alopecia

    Directory of Open Access Journals (Sweden)

    Talavera-Adame D

    2017-08-01

    Full Text Available Dodanim Talavera-Adame,1 Daniella Newman,2 Nathan Newman1 1American Advanced Medical Corp. (Private Practice, Beverly Hills, CA, 2Western University of Health Sciences, Pomona, CA, USA Abstract: The prevalence of androgenic alopecia (AGA increases with age and it affects both men and women. Patients diagnosed with AGA may experience decreased quality of life, depression, and feel self-conscious. There are a variety of therapeutic options ranging from prescription drugs to non-prescription medications. Currently, AGA involves an annual global market revenue of US$4 billion and a growth rate of 1.8%, indicating a growing consumer market. Although natural and synthetic ingredients can promote hair growth and, therefore, be useful to treat AGA, some of them have important adverse effects and unknown mechanisms of action that limit their use and benefits. Biologic factors that include signaling from stem cells, dermal papilla cells, and platelet-rich plasma are some of the current therapeutic agents being studied for hair restoration with milder side effects. However, most of the mechanisms exerted by these factors in hair restoration are still being researched. In this review, we analyze the therapeutic agents that have been used for AGA and emphasize the potential of new therapies based on advances in stem cell technologies and regenerative medicine. Keywords: stem cells, stem cell therapies, hair follicle, dermal papilla, androgenic alopecia, laser, hair regeneration

  11. Electronic equipment packaging technology

    CERN Document Server

    Ginsberg, Gerald L

    1992-01-01

    The last twenty years have seen major advances in the electronics industry. Perhaps the most significant aspect of these advances has been the significant role that electronic equipment plays in almost all product markets. Even though electronic equipment is used in a broad base of applications, many future applications have yet to be conceived. This versatility of electron­ ics has been brought about primarily by the significant advances that have been made in integrated circuit technology. The electronic product user is rarely aware of the integrated circuits within the equipment. However, the user is often very aware of the size, weight, mod­ ularity, maintainability, aesthetics, and human interface features of the product. In fact, these are aspects of the products that often are instrumental in deter­ mining its success or failure in the marketplace. Optimizing these and other product features is the primary role of Electronic Equipment Packaging Technology. As the electronics industry continues to pr...

  12. Current status of accelerator-based boron neutron capture therapy

    International Nuclear Information System (INIS)

    Kreiner, A. J.; Bergueiro, J.; Di Paolo, H.; Castell, W.; Vento, V. Thatar; Cartelli, D.; Kesque, J.M.; Valda, A.A.; Ilardo, J.C.; Baldo, M.; Erhardt, J.; Debray, M.E.; Somacal, H.R.; Estrada, L.; Sandin, J.C. Suarez; Igarzabal, M.; Huck, H.; Padulo, J.; Minsky, D.M.

    2011-01-01

    The direct use of proton and heavy ion beams for radiotherapy is a well established cancer treatment modality, which is becoming increasingly widespread due to its clear advantages over conventional photon-based treatments. This strategy is suitable when the tumor is spatially well localized. Also the use of neutrons has a long tradition. Here Boron Neutron Capture Therapy (BNCT) stands out, though on a much smaller scale, being a second-generation promising alternative for tumors which are diffuse and infiltrating. On this sector, so far only nuclear reactors have been used as neutron sources. In this paper we describe the current situation worldwide as far as the use of accelerator-based neutron sources for BNCT is concerned (so-called Accelerator-Based (AB)-BNCT). In particular we discuss the present status of an ongoing project to develop a folded Tandem-ElectroStatic-Quadrupole (TESQ) accelerator at the Atomic Energy Commission of Argentina. The project goal is a machine capable of delivering 30 mA of 2.4 MeV protons to be used in conjunction with a neutron production target based on the 7 Li(p,n) 7 Be reaction. These are the specifications needed to produce sufficiently intense and clean epithermal neutron beams to perform BNCT for deep-seated tumors in less than an hour. (author)

  13. [Cardiac resynchronization therapy for heart failure - from experimental pacing to evidence-based therapy].

    Science.gov (United States)

    Götze, S; Butter, C; Fleck, E

    2006-01-01

    Within the last decade, cardiac resynchronization therapy (CRT) has become an evidence-based cornerstone for a subset of patients with chronic heart failure. For those, who suffer from ischemic or non-ischemic cardiomyopathies at NYHA III or IV, have sinus rhythm, a left bundle branch block and a left ventricular ejection fraction below 35%, CRT has evolved as an important treatment option with promising results. Numerous studies have shown that in these patients pacemaker-mediated correction of intra- and interventicular conduction disturbances can improve not only clinical symptoms, exercise tolerance and the frequency of hospitalizations, but even more important the overall mortality. These clinical results are due to several functional aspects. In the failing heart characteristic intra- and interventricular alterations in electrical conduction result in mechanical asynchrony that leads to an abnormal contraction of the left ventricle with delayed activation of the lateral wall, a paradoxical septal movement, a reduced diastolic filling and a mitral regurgitation due to dyssynchrony of papillary muscle activation. It is conceivable that these functional changes have fatal consequences for the failing heart. AV-optimized left- or biventricular stimulation by modern pacemakers can correct the pathological dyssynchrony, thereby improving cardiac function and clinical outcome in these patients. Although tremendous progress in cardiac resynchronization therapy has been made during the last decade, a couple of questions still need to be resolved. Critical issues are the identification of patients, who will predictably benefit from CRT, the value of CRT-pacemakers versus CRT-ICDs, and the usefullness of CRT in patients with atrial fibrillation.

  14. Incretin-based therapy and type 2 diabetes

    DEFF Research Database (Denmark)

    Hare, Kristine J; Knop, Filip Krag

    2010-01-01

    This chapter focuses on the incretin hormones, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP), and their therapeutic potential in treating patients with type 2 diabetes. Type 2 diabetes is characterized by insulin resistance, impaired glucose-induced insulin...... secretion, and inappropriately regulated glucagon secretion which in combination eventually result in hyperglycemia and in the longer term microvascular and macrovascular diabetic complications. Traditional treatment modalities--even multidrug approaches--for type 2 diabetes are often unsatisfactory....... Two new drug classes based on the actions of the incretin hormones have been approved for therapy of type 2 diabetes: injectable long-acting stable analogs of GLP-1, incretin mimetics, and orally available inhibitors of dipeptidyl peptidase 4 (DPP4; the enzyme responsible for the rapid degradation...

  15. Incretin-based therapy and type 2 diabetes

    DEFF Research Database (Denmark)

    Hare, Kristine J; Knop, Filip Krag

    2010-01-01

    This chapter focuses on the incretin hormones, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP), and their therapeutic potential in treating patients with type 2 diabetes. Type 2 diabetes is characterized by insulin resistance, impaired glucose-induced insulin....... Two new drug classes based on the actions of the incretin hormones have been approved for therapy of type 2 diabetes: injectable long-acting stable analogs of GLP-1, incretin mimetics, and orally available inhibitors of dipeptidyl peptidase 4 (DPP4; the enzyme responsible for the rapid degradation...... secretion, and inappropriately regulated glucagon secretion which in combination eventually result in hyperglycemia and in the longer term microvascular and macrovascular diabetic complications. Traditional treatment modalities--even multidrug approaches--for type 2 diabetes are often unsatisfactory...

  16. The effect of mindfulness-based therapy for cancer patients

    DEFF Research Database (Denmark)

    Piet, Jacob

    Objective: The use of mindfulness-based therapy (MBT) in oncology settings has become increasingly popular, and research in the field has rapidly expanded. The objective was by means of a systematic review and meta-analysis to evaluate the current evidence for the effect of MBT on symptoms...... effect size analyses were performed separately for nonrandomized studies (K 13, n 448) and randomized controlled trials (RCTs; K 9, n 955). Effect sizes were combined using the random-effects model. Results: In the aggregated sample of nonrandomized studies (average quality score: 0.5), MBT...... was associated with significantly reduced symptoms of anxiety and depression from pre- to posttreatment corresponding to moderate effect sizes (Hedges’s g) of 0.60 and 0.42, respectively. The pooled controlled effect sizes (Hedges’s g) of RCTs (average quality score: 2.9) were 0.37 for anxiety symptoms (p .001...

  17. Nucleic Acid-Based Therapy Approaches for Huntington's Disease

    Directory of Open Access Journals (Sweden)

    Tatyana Vagner

    2012-01-01

    Full Text Available Huntington's disease (HD is caused by a dominant mutation that results in an unstable expansion of a CAG repeat in the huntingtin gene leading to a toxic gain of function in huntingtin protein which causes massive neurodegeneration mainly in the striatum and clinical symptoms associated with the disease. Since the mutation has multiple effects in the cell and the precise mechanism of the disease remains to be elucidated, gene therapy approaches have been developed that intervene in different aspects of the condition. These approaches include increasing expression of growth factors, decreasing levels of mutant huntingtin, and restoring cell metabolism and transcriptional balance. The aim of this paper is to outline the nucleic acid-based therapeutic strategies that have been tested to date.

  18. Biological-based optimization and volumetric modulated arc therapy delivery for stereotactic body radiation therapy

    International Nuclear Information System (INIS)

    Diot, Quentin; Kavanagh, Brian; Timmerman, Robert; Miften, Moyed

    2012-01-01

    Purpose: To describe biological-based optimization and Monte Carlo (MC) dose calculation-based treatment planning for volumetric modulated arc therapy (VMAT) delivery of stereotactic body radiation therapy (SBRT) in lung, liver, and prostate patients. Methods: Optimization strategies and VMAT planning parameters using a biological-based optimization MC planning system were analyzed for 24 SBRT patients. Patients received a median dose of 45 Gy [range, 34-54 Gy] for lung tumors in 1-5 fxs and a median dose of 52 Gy [range, 48-60 Gy] for liver tumors in 3-6 fxs. Prostate patients received a fractional dose of 10 Gy in 5 fxs. Biological-cost functions were used for plan optimization, and its dosimetric quality was evaluated using the conformity index (CI), the conformation number (CN), the ratio of the volume receiving 50% of the prescription dose over the planning target volume (Rx/PTV50). The quality and efficiency of the delivery were assessed according to measured quality assurance (QA) passing rates and delivery times. For each disease site, one patient was replanned using physical cost function and compared to the corresponding biological plan. Results: Median CI, CN, and Rx/PTV50 for all 24 patients were 1.13 (1.02-1.28), 0.79 (0.70-0.88), and 5.3 (3.1-10.8), respectively. The median delivery rate for all patients was 410 MU/min with a maximum possible rate of 480 MU/min (85%). Median QA passing rate was 96.7%, and it did not significantly vary with the tumor site. Conclusions: VMAT delivery of SBRT plans optimized using biological-motivated cost-functions result in highly conformal dose distributions. Plans offer shorter treatment-time benefits and provide efficient dose delivery without compromising the plan conformity for tumors in the prostate, lung, and liver, thereby improving patient comfort and clinical throughput. The short delivery times minimize the risk of patient setup and intrafraction motion errors often associated with long SBRT treatment

  19. Cryogenic equipment

    International Nuclear Information System (INIS)

    Leger, L.; Javellaud, J.; Caro, C.; Gilguy, R.; Testard, O.

    1966-06-01

    The cryostats presented here were built from standard parts; this makes it possible to construct a great variety of apparatus at minimum cost. The liquid nitrogen and helium reservoirs were designed so as to reduce losses to a minimum, and so as to make the cryostats as autonomous as possible. The experimental enclosure which is generally placed in the lower part of the apparatus requires a separate study in every case. Furthermore, complete assemblies such as transfer rods, isolated traps and high vacuum valves, were designed with a similar regard for the economic aspects and for the need for standardization. This equipment thus satisfies a great variety of experimental needs; it is readily adaptable and the consumptions of helium and liquid nitrogen are very low. (authors) [fr

  20. Molecular biology-based diagnosis and therapy for pancreatic cancer

    International Nuclear Information System (INIS)

    Fujita, Hayato; Ohuchida, Kenoki; Mizumoto, Kazuhiro; Tanaka, Masao

    2011-01-01

    Mainly described are author's investigations of the title subject through clinical and basic diagnosis/therapeutic approach. Based on their consideration of carcinogenesis and pathological features of pancreatic cancer (PC), analysis of expression of cancer-related genes in clinically available samples like pancreatic juice and cells biopsied can result in attaining their purposes. Desmoplasia, a pathological feature of PC, possibly induces resistance to therapy and one of strategies is probably its suppression. Targeting stem cells of the mesenchyma as well as those of PC is also a strategy in future. Authors' studies have revealed that quantitation of hTERT (coding teromerase) mRNA levels in PC cells micro-dissected from cytological specimens is an accurate molecular biological diagnostic method applicable clinically. Other cancer-related genes are also useful for the diagnosis and mucin (MUC) family genes are shown to be typical ones for differentiating the precancerous PC, PC and chronic pancreatisis. Efficacy of standard gemcitabine chemotherapy can be individualized with molecular markers concerned to metabolism of the drug like dCK. Radiotherapy/radio-chemotherapy are not so satisfactory for PC treatment now. Authors have found elevated MMP-2 expression and HGF/c-Met signal activation in irradiated PC cells, which can increase the invasive capability; and stimulation of phosphorylation and activation of c-Met/MARK in co-culture of irradiated PC cells with messenchymal cells from PC, which possibly leads to progression of malignancy of PC through their interaction, of which suppression, therefore, can be a new approach to increase the efficacy of radiotherapy. Authors are making effort to introducing adenovirus therapy in clinic; exempli gratia (e.g.), the virus carrying wild type p53, a cancer-suppressive gene, induces apoptosis of PC cells often having its mutated gene. (T.T.)

  1. Treatment of selective mutism based on cognitive behavioural therapy, psychopharmacology and combination therapy - a systematic review.

    Science.gov (United States)

    Østergaard, Kasper Rud

    2018-02-15

    Selective mutism (SM) is a debilitating childhood anxiety disorder characterized by a persistent lack of speech in certain social settings and is considered hard to treat. Cognitive behavioral therapy (CBT) and pharmacological treatments are the best described treatments in the literature. To test whether there is evidence on treatment based on CBT, medication or a combination of these. Systematic and critical review of the literature on CBT and/or pharmacological treatments of SM. Literature was sought on PubMed, Embase and Psycinfo in March 2017. Of the included studies, six examined CBT, seven pharmacologic treatment and two a combination of these. Using CBT 53/60 children improved symptomatically whilst respectively 55/67 and 6/7 improved using pharmacologic- and combination-treatment. Pharmacologic treatment and especially CBT showed promising results supported by some degree of evidence, which combination treatment lacks. Yet small numbers, few RCTs, heterogeneous study designs, lack of consistent measures, short treatment and follow-up periods, generally limits the evidence. This needs focus in future research.

  2. A beam monitor based on MPGD detectors for hadron therapy

    Directory of Open Access Journals (Sweden)

    Altieri P. R.

    2018-01-01

    Full Text Available Remarkable scientific and technological progress during the last years has led to the construction of accelerator based facilities dedicated to hadron therapy. This kind of technology requires precise and continuous control of position, intensity and shape of the ions or protons used to irradiate cancers. Patient safety, accelerator operation and dose delivery should be optimized by a real time monitoring of beam intensity and profile during the treatment, by using non-destructive, high spatial resolution detectors. In the framework of AMIDERHA (AMIDERHA - Enhanced Radiotherapy with HAdron project funded by the Ministero dell’Istruzione, dell’Università e della Ricerca (Italian Ministry of Education and Research the authors are studying and developing an innovative beam monitor based on Micro Pattern Gaseous Detectors (MPDGs characterized by a high spatial resolution and rate capability. The Monte Carlo simulation of the beam monitor prototype was carried out to optimize the geometrical set up and to predict the behavior of the detector. A first prototype has been constructed and successfully tested using 55Fe, 90Sr and also an X-ray tube. Preliminary results on both simulations and tests will be presented.

  3. Parent Perceptions of School-Based Occupational Therapy Services

    Science.gov (United States)

    Benson, Jeryl D.; Elkin, Kathleen; Wechsler, Julie; Byrd, Lindsey

    2015-01-01

    This study aims to explore the perceptions of parents of children receiving occupational therapy in educational settings, understand the importance of the parent/occupational therapist relationship and its impact on the outcomes of therapy. In addition, this study aims to reveal best practices when providing services within the school system in…

  4. Chapter 12. Space Heating Equipment

    Energy Technology Data Exchange (ETDEWEB)

    Rafferty, Kevin D.

    1998-01-01

    The performance evaluation of space heating equipment for a geothermal application is generally considered from either of two perspectives: (a) selecting equipment for installation in new construction, or (b) evaluating the performance and retrofit requirements of an existing system. With regard to new construction, the procedure is relatively straightforward. Once the heating requirements are determined, the process need only involve the selection of appropriately sized hot water heating equipment based on the available water temperature. It is important to remember that space heating equipment for geothermal applications is the same equipment used in non-geothermal applications. What makes geothermal applications unique is that the equipment is generally applied at temperatures and flow rates that depart significantly from traditional heating system design. This chapter presents general considerations for the performance of heating equipment at non-standard temperature and flow conditions, retrofit of existing systems, and aspects of domestic hot water heating.

  5. Generic data base for security equipment and its utility in the safeguards inspection process. Final report 8151-79-FR-16

    International Nuclear Information System (INIS)

    Scala, S.

    1979-01-01

    This report contains material presented at the Nuclear Regulatory Commission (NRC) conference of regional inspectors in Atlanta, Georgia, on January 17, 1979. It describes the contents of the generic data base for security equipment, which was developed by SRI for NRC under a Sandia Laboratories' subcontract, and examines its potential utility in the process of inspection of NRC-licensed facilities

  6. [Legionella pneumonia after the use of CPAP equipment].

    Science.gov (United States)

    Stolk, Jaap M; Russcher, Anne; van Elzakker, Erika P M; Schippers, Emile F

    2016-01-01

    Continuous positive airway pressure (CPAP) equipment can be colonised by Legionellae and might cause Legionella pneumonia in the user. However, there is no reported case of Legionella pneumonia related to CPAP equipment in which an identical Legionella was found in both the patient and the CPAP equipment. A 51-year-old man came to the Emergency Department with fever, confusion and dyspnoea that had been present for 3 days. His medical history included obstructive sleep apnoea, for which he had been using CPAP therapy at home for 10 weeks. The CPAP equipment showed signs of poor maintenance. Chest X-ray revealed a pulmonary consolidation. Laboratory investigation resulted in a positive urine antigen test for Legionella. Water from the CPAP equipment and sputum from the patient revealed Legionella pneumophila. Serotyping and sequence-based typing showed an identical L. pneumophila serotype 1 ST37. It is important to be aware that CPAP equipment can be colonised with Legionellae and might cause Legionella pneumonia. It is therefore necessary to ask about CPAP therapy in a patient with community-acquired pneumonia.

  7. Stem cell-based therapies for acute radiation syndrome

    International Nuclear Information System (INIS)

    Guha, Chandan

    2014-01-01

    Exposure to high doses of ionizing radiation in the event of accidental or intentional incident such as nuclear/radiological terrorism can lead to debilitating injuries to multiple organs resulting in death within days depending on the amount of radiation dose and the quality of radiation. Unfortunately, there is not a single FDA-licensed drug approved against acute radiation injury. The RadStem Center for Medical Countermeasures against Radiation (RadStem CMGR) program at Einstein is developing stem cell-based therapies to treat acute radiation syndrome (ARS). We have demonstrated that intravenous transplantation of bone marrow-derived and adipose-derived stromal cells, consisting of a mixture of mesenchymal, endothelial and myeloid progenitors can mitigate mice exposed to whole body irradiation of 12 Gy or whole abdominal irradiation of up to 20 Gy. We identified a variety of growth and differentiation factors that individually is unable to improve survival of animals exposed to lethal irradiation, but when administered sequentially mitigates radiation injury and improves survival. We termed this phenomenon as synthetic survival and describe a new paradigm whereby the 'synthetic survival' of irradiated tissues can be promoted by systemic administration of growth factors to amplify residual stem cell clonogens post-radiation exposure, followed by a differentiation factor that favors tissue stem cell differentiation. Synthetic survival can be applied to mitigate lethal radiation injury in multiple organs following radiation-induced hematopoeitic, gastrointestinal and pulmonary syndromes. (author)

  8. Potential of Stem Cell-Based Therapy for Ischemic Stroke

    Directory of Open Access Journals (Sweden)

    Hany E. Marei

    2018-02-01

    Full Text Available Ischemic stroke is one of the major health problems worldwide. The only FDA approved anti-thrombotic drug for acute ischemic stroke is the tissue plasminogen activator. Several studies have been devoted to assessing the therapeutic potential of different types of stem cells such as neural stem cells (NSCs, mesenchymal stem cells, embryonic stem cells, and human induced pluripotent stem cell-derived NSCs as treatments for ischemic stroke. The results of these studies are intriguing but many of them have presented conflicting results. Additionally, the mechanism(s by which engrafted stem/progenitor cells exert their actions are to a large extent unknown. In this review, we will provide a synopsis of different preclinical and clinical studies related to the use of stem cell-based stroke therapy, and explore possible beneficial/detrimental outcomes associated with the use of different types of stem cells. Due to limited/short time window implemented in most of the recorded clinical trials about the use of stem cells as potential therapeutic intervention for stroke, further clinical trials evaluating the efficacy of the intervention in a longer time window after cellular engraftments are still needed.

  9. Development of lithium target for accelerator based neutron capture therapy

    International Nuclear Information System (INIS)

    Taskaev, Sergey; Bayanov, Boris; Belov, Victor; Zhoorov, Eugene

    2006-01-01

    Pilot innovative accelerator based neutron source for neutron capture therapy of cancer is now of the threshold of its operation at the BINP, Russia. One of the main elements of the facility is lithium target producing neutrons via threshold 7 Li(p,n) 7 Be reaction at 25 kW proton beam with energies 1.915 MeV or 2.5 MeV. The main problems of lithium target were determined to be: 7 Be radioactive isotope activation keeping lithium layer solid, presence of photons due to proton inelastic scattering on lithium nuclei, and radiation blistering. The results of thermal test of target prototype were presented as previous NCT Congress. It becomes clear that water is preferable for cooling the target, and that lithium target 10 cm in diameter is able to run before melting. In the present report, the conception of optimal target is proposed: thin metal disk 10 cm in diameter easy for detaching, with evaporated thin layer of pure lithium from the side of proton beam exposure, its back being intensively cooled with turbulent water flow to maintain lithium layer solid. Design of the target for the neutron source constructed at BINP is shown. The results of investigation of radiation blistering and lithium layer are presented. Target unit of facility is under construction now, and obtaining neutrons is expected in nearest future. (author)

  10. Conventional and novel stem cell based therapies for androgenic alopecia.

    Science.gov (United States)

    Talavera-Adame, Dodanim; Newman, Daniella; Newman, Nathan

    2017-01-01

    The prevalence of androgenic alopecia (AGA) increases with age and it affects both men and women. Patients diagnosed with AGA may experience decreased quality of life, depression, and feel self-conscious. There are a variety of therapeutic options ranging from prescription drugs to non-prescription medications. Currently, AGA involves an annual global market revenue of US$4 billion and a growth rate of 1.8%, indicating a growing consumer market. Although natural and synthetic ingredients can promote hair growth and, therefore, be useful to treat AGA, some of them have important adverse effects and unknown mechanisms of action that limit their use and benefits. Biologic factors that include signaling from stem cells, dermal papilla cells, and platelet-rich plasma are some of the current therapeutic agents being studied for hair restoration with milder side effects. However, most of the mechanisms exerted by these factors in hair restoration are still being researched. In this review, we analyze the therapeutic agents that have been used for AGA and emphasize the potential of new therapies based on advances in stem cell technologies and regenerative medicine.

  11. Stem Cell-Based Therapies for Polyglutamine Diseases.

    Science.gov (United States)

    Mendonça, Liliana S; Onofre, Isabel; Miranda, Catarina Oliveira; Perfeito, Rita; Nóbrega, Clévio; de Almeida, Luís Pereira

    2018-01-01

    Polyglutamine (polyQ) diseases are a family of neurodegenerative disorders with very heterogeneous clinical presentations, although with common features such as progressive neuronal death. Thus, at the time of diagnosis patients might present an extensive and irreversible neuronal death demanding cell replacement or support provided by cell-based therapies. For this purpose stem cells, which include diverse populations ranging from embryonic stem cells (ESCs), to fetal stem cells, mesenchymal stromal cells (MSCs) or induced pluripotent stem cells (iPSCs) have remarkable potential to promote extensive brain regeneration and recovery in neurodegenerative disorders. This regenerative potential has been demonstrated in exciting pre and clinical assays. However, despite these promising results, several drawbacks are hampering their successful clinical implementation. Problems related to ethical issues, quality control of the cells used and the lack of reliable models for the efficacy assessment of human stem cells. In this chapter the main advantages and disadvantages of the available sources of stem cells as well as their efficacy and potential to improve disease outcomes are discussed.

  12. Efficient and compact mobile equipment based on the new RADEON-NWM technology to process liquid radioactive wastes resulted from the accidents of the nuclear installations

    International Nuclear Information System (INIS)

    Martoyan, Gagik; Nalbandyan, Garik; Gagiyan, Lavrenti; Karamyan, Gagik; Brutyan, Gagik

    2013-01-01

    During the operation of nuclear reactors important volume of liquid and solid radioactive wastes are generated, which, in normal conditions, becomes processed by stationary equipment by different methods to minimize their volume and then sent to specially constructed storages. The cases of accidents of Chernobyl and Fukushima showed that the localization of rejected big quantity of radioactive wastes is a prior problem for their further processing by stationary equipment. In this regard it is very important the processing of radioactive wastes on the contaminated areas to localize them by mobile equipment based on the efficient technologies. RADEONNWM new technology allows resolving this problem. This technology is compact, completely automated, which makes possible to assemble it on a standard 40-ft by 7-ft trailer driven by heavy-duty truck. The new technology is fully elaborated, the necessary tests are conducted. (authors)

  13. Movement-based interaction applied to physical rehabilitation therapies.

    Science.gov (United States)

    Garrido Navarro, Juan Enrique; Ruiz Penichet, Victor Manuel; Lozano Pérez, María Dolores

    2014-12-09

    Health care environments are continuously improving conditions, especially regarding the use of current technology. In the field of rehabilitation, the use of video games and related technology has helped to develop new rehabilitation procedures. Patients are able to work on their disabilities through new processes that are more motivating and entertaining. However, these patients are required to leave their home environment to complete their rehabilitation programs. The focus of our research interests is on finding a solution to eliminate the need for patients to interrupt their daily routines to attend rehabilitation therapy. We have developed an innovative system that allows patients with a balance disorder to perform a specific rehabilitation exercise at home. Additionally, the system features an assistive tool to complement the work of physiotherapists. Medical staff are thus provided with a system that avoids the need for them to be present during the exercise in specific cases in which patients are under suitable supervision. A movement-based interaction device was used to achieve a reliable system for monitoring rehabilitation exercises performed at home. The system accurately utilizes parameters previously defined by the specialist for correct performance of the exercise. Accordingly, the system gives instructions and corrects the patient's actions. The data generated during the session are collected for assessment by the specialist to adapt the difficulty of the exercise to the patient's progress. The evaluation of the system was conducted by two experts in balance disorder rehabilitation. They were required to verify the effectiveness of the system, and they also facilitated the simulation of real patient behavior. They used the system freely for a period of time and provided interesting and optimistic feedback. First, they evaluated the system as a tool for real-life rehabilitation therapy. Second, their interaction with the system allowed us to obtain

  14. Development of the graphic design and control system based on a graphic simulator for the spent fuel dismantling equipment

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. Y.; Kim, S. H.; Song, T. G.; Yoon, J. S

    2000-06-01

    In this study, the graphic design system is developed for designing the spent fuel rod consolidation and the dismantling processes. This system is used throughout the design stages from the conceptual design to the motion analysis. Also, the real-time control system of the rod extracting equipment is developed. This system utilizes the graphic simulator which simulates the motion of the equipment in real time by synchronously connecting the control PC with the graphic server through the TCP/IP network. The developed system is expected to be used as an effective tool in designing the process equipment for the spent fuel management. And the real-time graphic control system can be effectively used to enhance the reliability and safety of the spent fuel handling process by providing the remote monitoring function of the process.

  15. A model and solving algorithm of combination planning for weapon equipment based on Epoch-era analysis method

    Science.gov (United States)

    Wang, Meng; Zhang, Huaiqiang; Zhang, Kan

    2017-10-01

    Focused on the circumstance that the equipment using demand in the short term and the development demand in the long term should be made overall plans and took into consideration in the weapons portfolio planning and the practical problem of the fuzziness in the definition of equipment capacity demand. The expression of demand is assumed to be an interval number or a discrete number. With the analysis method of epoch-era, a long planning cycle is broke into several short planning cycles with different demand value. The multi-stage stochastic programming model is built aimed at maximize long-term planning cycle demand under the constraint of budget, equipment development time and short planning cycle demand. The scenario tree is used to discretize the interval value of the demand, and genetic algorithm is designed to solve the problem. At last, a case is studied to demonstrate the feasibility and effectiveness of the proposed mode.

  16. Design of online monitoring and forecasting system for electrical equipment temperature of prefabricated substation based on WSN

    Science.gov (United States)

    Qi, Weiran; Miao, Hongxia; Miao, Xuejiao; Xiao, Xuanxuan; Yan, Kuo

    2016-10-01

    In order to ensure the safe and stable operation of the prefabricated substations, temperature sensing subsystem, temperature remote monitoring and management subsystem, forecast subsystem are designed in the paper. Wireless temperature sensing subsystem which consists of temperature sensor and MCU sends the electrical equipment temperature to the remote monitoring center by wireless sensor network. Remote monitoring center can realize the remote monitoring and prediction by monitoring and management subsystem and forecast subsystem. Real-time monitoring of power equipment temperature, history inquiry database, user management, password settings, etc., were achieved by monitoring and management subsystem. In temperature forecast subsystem, firstly, the chaos of the temperature data was verified and phase space is reconstructed. Then Support Vector Machine - Particle Swarm Optimization (SVM-PSO) was used to predict the temperature of the power equipment in prefabricated substations. The simulation results found that compared with the traditional methods SVM-PSO has higher prediction accuracy.

  17. Development of the graphic design and control system based on a graphic simulator for the spent fuel dismantling equipment

    International Nuclear Information System (INIS)

    Lee, J. Y.; Kim, S. H.; Song, T. G.; Yoon, J. S.

    2000-06-01

    In this study, the graphic design system is developed for designing the spent fuel rod consolidation and the dismantling processes. This system is used throughout the design stages from the conceptual design to the motion analysis. Also, the real-time control system of the rod extracting equipment is developed. This system utilizes the graphic simulator which simulates the motion of the equipment in real time by synchronously connecting the control PC with the graphic server through the TCP/IP network. The developed system is expected to be used as an effective tool in designing the process equipment for the spent fuel management. And the real-time graphic control system can be effectively used to enhance the reliability and safety of the spent fuel handling process by providing the remote monitoring function of the process

  18. Prioritizing equipment for replacement.

    Science.gov (United States)

    Capuano, Mike

    2010-01-01

    It is suggested that clinical engineers take the lead in formulating evaluation processes to recommend equipment replacement. Their skill, knowledge, and experience, combined with access to equipment databases, make them a logical choice. Based on ideas from Fennigkoh's scheme, elements such as age, vendor support, accumulated maintenance cost, and function/risk were used.6 Other more subjective criteria such as cost benefits and efficacy of newer technology were not used. The element of downtime was also omitted due to the data element not being available. The resulting Periop Master Equipment List and its rationale was presented to the Perioperative Services Program Council. They deemed the criteria to be robust and provided overwhelming acceptance of the list. It was quickly put to use to estimate required capital funding, justify items already thought to need replacement, and identify high-priority ranked items for replacement. Incorporating prioritization criteria into an existing equipment database would be ideal. Some commercially available systems do have the basic elements of this. Maintaining replacement data can be labor-intensive regardless of the method used. There is usually little time to perform the tasks necessary for prioritizing equipment. However, where appropriate, a clinical engineering department might be able to conduct such an exercise as shown in the following case study.

  19. Medical Issues: Equipment

    Science.gov (United States)

    ... Information Packets Equipment Pool Living With SMA Medical Issues Palliative Breathing Orthopedics Nutrition Equipment Daily Life At ... curesma.org > support & care > living with sma > medical issues > equipment Equipment Individuals with SMA often require a ...

  20. Hydrate-based methane separation from coal mine methane gas mixture by bubbling using the scale-up equipment

    International Nuclear Information System (INIS)

    Cai, Jing; Xu, Chun-Gang; Xia, Zhi-Ming; Chen, Zhao-Yang; Li, Xiao-Sen

    2017-01-01

    Highlights: •Hydrate-based methane separation was achieved in the large scale using SHW-II. •Bubbling method was beneficial to reduce energy consumption. •The optimal conditions were determined. •The morphology and flow characteristic of hydrate formation were filmed. -- Abstract: In this work, the hydrate-based methane (CH 4 ) separation from coal mine methane (CMM) gas mixture was carried out by bubbling with a scale-up equipment (SHW-II). The influences of gas/liquid volume ratios (0.25 and 0.60), gas bubble sizes (diameter: 20, 50 and 100 μm) and gas flow rates (7.50, 16.13 and 21.50 mL/min/L) on gas consumption and CH 4 recovery were systematically investigated at 277.15 K and 1.50 MPa. The hydrate formation morphology was filmed by a camera and the hydrate structure was determined by powder X-ray diffraction (PXRD). Gas bubbles generated when gas mixture flowed into bulk solution through a bubble plate from the bottom of SHW-II. Initially, the gas hydrates formed at the bubble boundary and grew up as the shell around the bubble with the continuously rising of the gas bubble, and finally accumulated in the interface between the gaseous phase and solution. The experimental results showed that the THF/CH 4 /N 2 hydrate in SHW-II presented structure II (sII). The gas/liquid volume ratio, gas bubble size and gas flow rate had influences on gas consumption and CH 4 recovery. The increase of gas/liquid volume ratio resulted in the decrease of gas consumption and CH 4 recovery, while the increase of gas flow rate caused the decrease of gas consumption. Both the maximum gas consumption and CH 4 recovery were achieved at the gas bubble with diameter of 50 μm. The optimal operating condition for large-scale CH 4 separation via clatharate hydrate was comprehensively defined as the gas/liquid volume ratio of 0.25, the gas bubble diameter of 50 μm and the gas flow rate of 16.13 mL/min/L at 277.15 K and 1.50 MPa.

  1. Equipment Operational Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Greenwalt, B; Henderer, B; Hibbard, W; Mercer, M

    2009-06-11

    The Iraq Department of Border Enforcement is rich in personnel, but poor in equipment. An effective border control system must include detection, discrimination, decision, tracking and interdiction, capture, identification, and disposition. An equipment solution that addresses only a part of this will not succeed, likewise equipment by itself is not the answer without considering the personnel and how they would employ the equipment. The solution should take advantage of the existing in-place system and address all of the critical functions. The solutions are envisioned as being implemented in a phased manner, where Solution 1 is followed by Solution 2 and eventually by Solution 3. This allows adequate time for training and gaining operational experience for successively more complex equipment. Detailed descriptions of the components follow the solution descriptions. Solution 1 - This solution is based on changes to CONOPs, and does not have a technology component. It consists of observers at the forts and annexes, forward patrols along the swamp edge, in depth patrols approximately 10 kilometers inland from the swamp, and checkpoints on major roads. Solution 2 - This solution adds a ground sensor array to the Solution 1 system. Solution 3 - This solution is based around installing a radar/video camera system on each fort. It employs the CONOPS from Solution 1, but uses minimal ground sensors deployed only in areas with poor radar/video camera coverage (such as canals and streams shielded by vegetation), or by roads covered by radar but outside the range of the radar associated cameras. This document provides broad operational requirements for major equipment components along with sufficient operational details to allow the technical community to identify potential hardware candidates. Continuing analysis will develop quantities required and more detailed tactics, techniques, and procedures.

  2. Semiconductor Manufacturing equipment introduction

    International Nuclear Information System (INIS)

    Im, Jong Sun

    2001-02-01

    This book deals with semiconductor manufacturing equipment. It is comprised of nine chapters, which are manufacturing process of semiconductor device, history of semiconductor manufacturing equipment, kinds and role of semiconductor manufacturing equipment, construction and method of semiconductor manufacturing equipment, introduction of various semiconductor manufacturing equipment, spots of semiconductor manufacturing, technical elements of semiconductor manufacturing equipment, road map of technology of semiconductor manufacturing equipment and semiconductor manufacturing equipment in the 21st century.

  3. Cell-based therapy technology classifications and translational challenges

    Science.gov (United States)

    Mount, Natalie M.; Ward, Stephen J.; Kefalas, Panos; Hyllner, Johan

    2015-01-01

    Cell therapies offer the promise of treating and altering the course of diseases which cannot be addressed adequately by existing pharmaceuticals. Cell therapies are a diverse group across cell types and therapeutic indications and have been an active area of research for many years but are now strongly emerging through translation and towards successful commercial development and patient access. In this article, we present a description of a classification of cell therapies on the basis of their underlying technologies rather than the more commonly used classification by cell type because the regulatory path and manufacturing solutions are often similar within a technology area due to the nature of the methods used. We analyse the progress of new cell therapies towards clinical translation, examine how they are addressing the clinical, regulatory, manufacturing and reimbursement requirements, describe some of the remaining challenges and provide perspectives on how the field may progress for the future. PMID:26416686

  4. Nanomaterial-based drug delivery carriers for cancer therapy

    CERN Document Server

    Feng, Tao

    2017-01-01

    This brief summarizes different types of organic and inorganic nanomaterials for drug delivery in cancer therapy. It highlights that precisely designed nanomaterials will be the next-generation therapeutic agents for cancer treatment.

  5. Cell-based therapies and imaging in cardiology.

    Science.gov (United States)

    Bengel, Frank M; Schachinger, Volker; Dimmeler, Stefanie

    2005-12-01

    Cell therapy for cardiac repair has emerged as one of the most exciting and promising developments in cardiovascular medicine. Evidence from experimental and clinical studies is increasing that this innovative treatment will influence clinical practice in the future. But open questions and controversies with regard to the basic mechanisms of this therapy continue to exist and emphasise the need for specific techniques to visualise the mechanisms and success of therapy in vivo. Several non-invasive imaging approaches which aim at tracking of transplanted cells in the heart have been introduced. Among these are direct labelling of cells with radionuclides or paramagnetic agents, and the use of reporter genes for imaging of cell transplantation and differentiation. Initial studies have suggested that these molecular imaging techniques have great potential. Integration of cell imaging into studies of cardiac cell therapy holds promise to facilitate further growth of the field towards a broadly clinically useful application.

  6. Cell-based therapies and imaging in cardiology

    Energy Technology Data Exchange (ETDEWEB)

    Bengel, Frank M. [Technische Universitaet Muenchen, Nuklearmedizinische Klinik und Poliklinik, Munich (Germany); Schachinger, Volker; Dimmeler, Stefanie [University of Frankfurt, Department of Molecular Cardiology, Frankfurt (Germany)

    2005-12-01

    Cell therapy for cardiac repair has emerged as one of the most exciting and promising developments in cardiovascular medicine. Evidence from experimental and clinical studies is increasing that this innovative treatment will influence clinical practice in the future. But open questions and controversies with regard to the basic mechanisms of this therapy continue to exist and emphasise the need for specific techniques to visualise the mechanisms and success of therapy in vivo. Several non-invasive imaging approaches which aim at tracking of transplanted cells in the heart have been introduced. Among these are direct labelling of cells with radionuclides or paramagnetic agents, and the use of reporter genes for imaging of cell transplantation and differentiation. Initial studies have suggested that these molecular imaging techniques have great potential. Integration of cell imaging into studies of cardiac cell therapy holds promise to facilitate further growth of the field towards a broadly clinically useful application. (orig.)

  7. Performing Art-Based Research: Innovation in Graduate Art Therapy Education

    Science.gov (United States)

    Moon, Bruce L.; Hoffman, Nadia

    2014-01-01

    This article presents an innovation in art therapy research and education in which art-based performance is used to generate, embody, and creatively synthesize knowledge. An art therapy graduate student's art-based process of inquiry serves to demonstrate how art and performance may be used to identify the research question, to conduct a process…

  8. Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies

    DEFF Research Database (Denmark)

    Gyöngyösi, Mariann; Wojakowski, Wojciech; Navarese, Eliano P

    2016-01-01

    In contrast to multiple publication-based meta-analyses involving clinical cardiac regeneration therapy in patients with recent myocardial infarction, a recently published meta-analysis based on individual patient data reported no effect of cell therapy on left ventricular function or clinical...

  9. The Cost of Maintaining Educational Communications Equipment.

    Science.gov (United States)

    Humphrey, David A.

    Tentative formulas for calculating the cost of maintaining educational communications equipment are proposed. The formulas are based on a survey of campuses of the State University of New York. The survey analyzed the types of equipment to be maintained, types of maintenance, who uses the equipment, who services the equipment, and the cost…

  10. [The study on behaviour of protective equipment utilization of workers exposed to benzene and factors based on Planned Behavior Theory].

    Science.gov (United States)

    Huang, J Y; Liu, C D; Zhang, W M; Fu, Y K; Ma, H Y

    2018-02-20

    Objective: To investigate and predict the behavioral intention and mode of the protective equipment utilization selection of the workers who used Benzene, the Theory of Planned Behavior (TPB) was applied to establish the behavioral model to enhance the theoretical foundation for long-term intervention. Methods: Questionnaires were used to survey the 707 workers, and all the behaviors of using protective equipment were investigated. Evaluate the relationships between each variable and obtain the influence affects by structural equation model. Results: The investigation showed that 38.47% of the total workers (272 cases) used whole body protection, 13.58% used partially, and 16.69% didn't use any body protection. There were significant difference between the varying degrees in the four dimensions (behavioral attitude, perceived behavior control, subjective norm, and behavioral intention) (Pbehavior control was the most important influencing factor, subjective norm, positive attitude, negative attitude were the other three respects in sequence. The path co-efficient were 0.600、0.215、0.141 and 0.046 respectively. Conclusion: The study show that the theory of planned behavior can effectively explain the behavioral intention and behavior of protective equipment utilization. Therefore, combining the subjective initiative of individuals with the supervision of enterprises, In order to effectively enhance the protective equipment utilization of benzene workers.

  11. Development of Smart Phthalocyanine-based Photosensitizers for Photodynamic Therapy

    Science.gov (United States)

    Chow, Yun Sang

    Phthalocyanines are versatile functional dyes that have shown great potential in cancer theranostics, especially in photodynamic therapy (PDT). This research work aims to develop "smart" phthalocyanine-based photosensitizers for targeted PDT. This thesis describes the synthesis, spectroscopic characterization, photophysical properties, and in vitro photodynamic activities of several series of carefully designed phthalocyanine-based photosensitizers. Chapter 1 presents an overview of PDT, including its historical development, photophysical mechanisms, and biological mechanisms. Various classes of photosensitizers are introduced with emphasis putting on phthalocyanines, which exhibit ideal characteristics of photosensitizers for PDT. In recent years, several approaches have been used to develop photosensitizers with higher tumor selectivity and minimal skin photosensitivity after PDT. Activatable photosensitizers can provide a "turn on" mechanism to offer an additional control of the specificity of treatment. Photosensitizers can also work cooperatively with the tumor-targeting groups or anticancer drugs so as to achieve targeted or dual therapy, which can enhance the efficacy of PDT. The novel approaches mentioned above have been widely used and combined to form multi-functional photosensitizing agents. These novel concepts and development of PDT are discussed and illustrated with relevant examples at the end of this chapter. To minimize the prolonged skin photosensitivity, photosensitizers that can only be activated by tumor-associated stimuli have been developed. Due to the abnormal metabolism in tumor tissues, their surface usually exhibits a lower pH compared to that of the normal tissues. Also, the pH difference between the intracellular and the physiological environment provides a pH-activation mechanism. Chapter 2 presents the synthesis and spectroscopic characterization of a pH-responsive zinc(II) phthalocyanine tetramer, in which the phthalocyanine units

  12. Couch height–based patient setup for abdominal radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Ohira, Shingo [Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka (Japan); Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita (Japan); Ueda, Yoshihiro [Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka (Japan); Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita (Japan); Nishiyama, Kinji [Department of Radiation Oncology, Yao Municipal Hospital, Yao (Japan); Miyazaki, Masayoshi; Isono, Masaru; Tsujii, Katsutomo [Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka (Japan); Takashina, Masaaki; Koizumi, Masahiko [Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Suita (Japan); Kawanabe, Kiyoto [Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka (Japan); Teshima, Teruki, E-mail: teshima-te@mc.pref.osaka.jp [Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka (Japan)

    2016-04-01

    There are 2 methods commonly used for patient positioning in the anterior-posterior (A-P) direction: one is the skin mark patient setup method (SMPS) and the other is the couch height–based patient setup method (CHPS). This study compared the setup accuracy of these 2 methods for abdominal radiation therapy. The enrollment for this study comprised 23 patients with pancreatic cancer. For treatments (539 sessions), patients were set up by using isocenter skin marks and thereafter treatment couch was shifted so that the distance between the isocenter and the upper side of the treatment couch was equal to that indicated on the computed tomographic (CT) image. Setup deviation in the A-P direction for CHPS was measured by matching the spine of the digitally reconstructed radiograph (DRR) of a lateral beam at simulation with that of the corresponding time-integrated electronic portal image. For SMPS with no correction (SMPS/NC), setup deviation was calculated based on the couch-level difference between SMPS and CHPS. SMPS/NC was corrected using 2 off-line correction protocols: no action level (SMPS/NAL) and extended NAL (SMPS/eNAL) protocols. Margins to compensate for deviations were calculated using the Stroom formula. A-P deviation > 5 mm was observed in 17% of SMPS/NC, 4% of SMPS/NAL, and 4% of SMPS/eNAL sessions but only in one CHPS session. For SMPS/NC, 7 patients (30%) showed deviations at an increasing rate of > 0.1 mm/fraction, but for CHPS, no such trend was observed. The standard deviations (SDs) of systematic error (Σ) were 2.6, 1.4, 0.6, and 0.8 mm and the root mean squares of random error (σ) were 2.1, 2.6, 2.7, and 0.9 mm for SMPS/NC, SMPS/NAL, SMPS/eNAL, and CHPS, respectively. Margins to compensate for the deviations were wide for SMPS/NC (6.7 mm), smaller for SMPS/NAL (4.6 mm) and SMPS/eNAL (3.1 mm), and smallest for CHPS (2.2 mm). Achieving better setup with smaller margins, CHPS appears to be a reproducible method for abdominal patient setup.

  13. Ilaj bil hijamah (cupping therapy) in the Unani system of medicine: anecdotal practice to evidence based therapy.

    Science.gov (United States)

    Abbas Zaidi, S M; Jameel, S S; Jafri, Kehkashan; Khan, Shariq A; Ahmad, Ehsan

    2016-08-01

    Cupping (Hijamah) therapy is very well documented as a result of several thousand years of clinical experiences in Unani medicine. In this procedure, suction is created by various means either with or without bloodletting. Though this therapy is being widely practiced across the globe for treating many chronic and intractable ailments but many reports reveal its unscientific and improper practices which results in many complications. Therefore to develop standard operative procedures and to propose protocols of cupping therapy in various diseases is the need of hour. A thorough literature review of relevant journals and textbooks was performed to gather the maximum available data on cupping therapy. This paper seeks to introduce the general concepts of cupping therapy in Unani medicine and other traditional systems of medicine, shortcomings and limitations of the currently published studies and suggest ways to improve these technical/methodological flaws. In addition, the authors have also attempted to provide the cupping related materials, hypotheses, observations which will provide the researchers the base for evaluating their usefulness in future clinical trials.

  14. Plasma-based determination of inorganic contaminants in waste of electric and electronic equipment after microwave-induced combustion

    Energy Technology Data Exchange (ETDEWEB)

    Mello, Paola A.; Diehl, Lisarb O.; Oliveira, Jussiane S.S.; Muller, Edson I. [Departamento de Química, Universidade Federal de Santa Maria, Av. Roraima, 1000, 97105-900, Santa Maria (Brazil); Mesko, Marcia F. [Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Capão do Leão, 96900-010 Pelotas, RS (Brazil); Flores, Erico M.M., E-mail: ericommf@gmail.com [Departamento de Química, Universidade Federal de Santa Maria, Av. Roraima, 1000, 97105-900, Santa Maria (Brazil)

    2015-03-01

    A systematic study was performed for the determination of inorganic contaminants in polymeric waste from electrical and electronic equipment (EEE) for achieving an efficient digestion to minimize interferences in determination using plasma-based techniques. The determination of As, Br, Cd, Co, Cr, Cu, Ni, Pb, Sb, and Zn by inductively coupled plasma mass spectrometry (ICP-MS) and also by inductively coupled plasma optical emission spectrometry (ICP OES) was carried out after digestion using microwave-induced combustion (MIC). Arsenic and Hg were determined by flow-injection chemical vapor generation inductively coupled plasma mass spectrometry (FI-CVG-ICP-MS). Dynamic reaction cell inductively coupled plasma mass spectrometry (DRC-ICP-MS) with ammonia was also used for Cr determination. The suitability of MIC for digestion of sample masses up to 400 mg was demonstrated using microcrystalline cellulose as aid for combustion of polymers from waste of EEEs that usually contain flame retardants that impair the combustion. The composition and concentration of acid solutions (HNO{sub 3} or HNO{sub 3} plus HCl) were evaluated for metals and metalloids and NH{sub 4}OH solutions were investigated for Br absorption. Accuracy was evaluated by comparison of results with those obtained using high pressure microwave-assisted wet digestion (HP-MAWD) and also by the analysis of certified reference material (CRM) of polymer (EC680k—low-density polyethylene). Bromine determination was only feasible using digestion by MIC once losses were observed when HP-MAWD was used. Lower limits of detection were obtained for all analytes using MIC (from 0.005 μg g{sup −1} for Co by ICP-MS up to 3.120 μg g{sup −1} for Sb by ICP OES) in comparison to HP-MAWD due to the higher sample mass that can be digested (400 mg) and the use of diluted absorbing solutions. The combination of HNO{sub 3} and HCl for digestion showed to be crucial for quantitative recovery of some elements, as Cr and Sb

  15. Empirically Based Psychosocial Therapies for Schizophrenia: The Disconnection between Science and Practice

    Directory of Open Access Journals (Sweden)

    Glenn D. Shean

    2013-01-01

    Full Text Available Empirically validated psychosocial therapies for individuals diagnosed with schizophrenia were described in the report of the Schizophrenia Patient Outcomes Research Team (PORT, 2009. The PORT team identified eight psychosocial treatments: assertive community treatment, supported employment, cognitive behavioral therapy, family-based services, token economy, skills training, psychosocial interventions for alcohol and substance use disorders, and psychosocial interventions for weight management. PORT listings of empirically validated psychosocial therapies provide a useful template for the design of effective recovery-oriented mental health care systems. Unfortunately, surveys indicate that PORT listings have not been implemented in clinical settings. Obstacles to the implementation of PORT psychosocial therapy listings and suggestions for changes needed to foster implementation are discussed. Limitations of PORT therapy listings that are based on therapy outcome efficacy studies are discussed, and cross-cultural and course and outcome studies of correlates of recovery are summarized.

  16. [Achievements and enlightenment of modern acupuncture therapy for stroke based on the neuroanatomy].

    Science.gov (United States)

    Chen, Li-Fang; Fang, Jian-Qiao; Chen, Lu-Ni; Wang, Chao

    2014-04-01

    Up to now, in the treatment of stroke patients by acupuncture therapy, three main representative achievements involving scalp acupuncture intervention, "Xing Nao Kai Qiao" (restoring consciousness and inducing resuscitation) acupuncture technique and nape acupuncture therapy have been got. Regarding their neurobiological mechanisms, the scalp acupuncture therapy is based on the functional localization of the cerebral cortex, "Xing Nao Kai Qiao" acupuncture therapy is closely related to nerve stem stimulation, and the nape acupuncture therapy is based on the nerve innervation of the regional neck-nape area in obtaining therapeutic effects. In fact, effects of these three acupuncture interventions are all closely associated with the modern neuroanatomy. In the treatment of post-stroke spastic paralysis, cognitive disorder and depression with acupuncture therapy, modern neuroanatomical knowledge should be one of the key theoretical basis and new therapeutic techniques should be explored and developed continuously.

  17. Information technology equipment cooling system

    Science.gov (United States)

    Schultz, Mark D.

    2014-06-10

    According to one embodiment, a system for removing heat from a rack of information technology equipment may include a sidecar indoor air to liquid heat exchanger that cools warm air generated by the rack of information technology equipment. The system may also include a liquid to liquid heat exchanger and an outdoor heat exchanger. The system may further include configurable pathways to connect and control fluid flow through the sidecar heat exchanger, the liquid to liquid heat exchanger, the rack of information technology equipment, and the outdoor heat exchanger based upon ambient temperature and/or ambient humidity to remove heat from the rack of information technology equipment.

  18. Management methodology for pressure equipment

    Science.gov (United States)

    Bletchly, P. J.

    Pressure equipment constitutes a significant investment in capital and a major proportion of potential high-risk plant in many operations and this is particularly so in an alumina refinery. In many jurisdictions pressure equipment is also subject to statutory regulation that imposes obligations on Owners of the equipment with respect to workplace safety. Most modern technical standards and industry codes of practice employ a risk-based approach to support better decision making with respect to pressure equipment. For a management system to be effective it must demonstrate that risk is being managed within acceptable limits.

  19. Nanomedicine-based combination anticancer therapy between nucleic acids and small-molecular drugs.

    Science.gov (United States)

    Huang, Wei; Chen, Liqing; Kang, Lin; Jin, Mingji; Sun, Ping; Xin, Xin; Gao, Zhonggao; Bae, You Han

    2017-06-01

    Anticancer therapy has always been a vital challenge for the development of nanomedicine. Repeated single therapeutic agent may lead to undesirable and severe side effects, unbearable toxicity and multidrug resistance due to complex nature of tumor. Nanomedicine-based combination anticancer therapy can synergistically improve antitumor outcomes through multiple-target therapy, decreasing the dose of each therapeutic agent and reducing side effects. There are versatile combinational anticancer strategies such as chemotherapeutic combination, nucleic acid-based co-delivery, intrinsic sensitive and extrinsic stimulus combinational patterns. Based on these combination strategies, various nanocarriers and drug delivery systems were engineered to carry out the efficient co-delivery of combined therapeutic agents for combination anticancer therapy. This review focused on illustrating nanomedicine-based combination anticancer therapy between nucleic acids and small-molecular drugs for synergistically improving anticancer efficacy. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Magnetic resonance imaging and cell-based neurorestorative therapy after brain injury

    Directory of Open Access Journals (Sweden)

    Quan Jiang

    2016-01-01

    Full Text Available Restorative cell-based therapies for experimental brain injury, such as stroke and traumatic brain injury, substantially improve functional outcome. We discuss and review state of the art magnetic resonance imaging methodologies and their applications related to cell-based treatment after brain injury. We focus on the potential of magnetic resonance imaging technique and its associated challenges to obtain useful new information related to cell migration, distribution, and quantitation, as well as vascular and neuronal remodeling in response to cell-based therapy after brain injury. The noninvasive nature of imaging might more readily help with translation of cell-based therapy from the laboratory to the clinic.

  1. Mindfulness-Based Cognitive Therapy as a Treatment for Chronic Tinnitus: A Randomized Controlled Trial

    OpenAIRE

    McKenna, L.; Marks, E. M.; Hallsworth, C. A.; Schaette, R.

    2017-01-01

    BACKGROUND: Tinnitus is experienced by up to 15% of the population and can lead to significant disability and distress. There is rarely a medical or surgical target and psychological therapies are recommended. We investigated whether mindfulness-based cognitive therapy (MBCT) could offer an effective new therapy for tinnitus. METHODS: This single-site randomized controlled trial compared MBCT to intensive relaxation training (RT) for chronic, distressing tinnitus in adults. Both treatments in...

  2. New directions for feminist therapy based on social constructionism.

    Science.gov (United States)

    Finfgeld, D L

    2001-06-01

    Feminist therapy has made significant contributions in the area of women's mental health care. Of late, however, critics have argued that feminist therapists are neglecting the needs of many women. The unique perspectives of women of color, lower and upper class women, lesbians, and other persons have been ignored. As such, it is proposed that social constructionism offers a metaframework for reinterpreting feminist therapy tenets to better address the needs of a broad range of individuals. Clinical implications are offered along with future directions for research and education. Copyright 2001 by W.B. Saunders Company

  3. Multiuser remote access to distributed heterogeneous system of programmable logic based laboratory equipment for remote digital circuits design labs

    Directory of Open Access Journals (Sweden)

    Mikhail N. Yokhin

    2017-12-01

    Full Text Available The paper contains an analysis of perspective structures of software and hardware equipment of universal digital design laboratories with the purpose of enabling laboratory classes of digital circuit design to be taken remotely. Implementation characteristics and usage experience of some of those structures applied to labs on several hardware related courses of « Computer science and computer engineering» program in NRNU MEPhI are presented. The paper also considers different aspects of usage of remote access enabled laboratory which should be taken into account to substantiate laboratory configuration from technical and economical standpoints. To increase equipment usage efficiency an approach to group several distinct projects to place them on a single FPGA chip is proposed. The paper shows advisability and gives an example of parametrizable virtual stand for remote debugging of FPGA projects.

  4. Radon removal equipment based on aeration: A literature study of tests performed in Sweden between 1981 and 1996

    International Nuclear Information System (INIS)

    Mjoenes, L.

    2000-02-01

    In Sweden some principles to reduce the radon concentration in drinking water were tested in the beginning of the 1980s. Spray aeration under atmospheric pressure, diffused bubble aeration, aeration in the pressure tank and different combinations of these principles were studied. Aeration in the drill hole and adsorption on granulated activated char-coal were also tested. The best results, about 70 % reduction, were obtained with aeration in the pressure tank with a spray system combined with diffused air bubbling. The Oerebro project in the beginning of the 1990s included on site testing of five different aeration solutions: Aeration in the drill hole, aeration in the storage tank, ejector aeration, shallow tray aeration and packed column aeration. The radon removal efficiency varied between 20 % and 99 %. In 1994 a study intended to test the radon removal capacity of different water treatment equipment was performed. Six units of radon separators were included but most of the tested equipment was installed for other water treatment purposes. The performed measurements showed that the only types of equipment that reduce the radon concentration efficiently are radon separators and reverse osmosis filters. The radon removal capacity of the radon separators varied between 23 % and 97 %. In 1996 the nine most common radon separators on the Swedish market were tested. The results showed that the tested radon removal equipment worked well, although the technical quality and chosen technical solutions were not always the best. The radon removal capacity of the units participating in this test was in most cases between 96 and 99 %. In some cases the capacity exceeded 99 %. In order to reach this radon removal capacity the water must be recirculated in a storage tank under atmospheric pressure

  5. Radon removal equipment based on aeration: A literature study of tests performed in Sweden between 1981 and 1996

    Energy Technology Data Exchange (ETDEWEB)

    Mjoenes, L

    2000-02-01

    In Sweden some principles to reduce the radon concentration in drinking water were tested in the beginning of the 1980s. Spray aeration under atmospheric pressure, diffused bubble aeration, aeration in the pressure tank and different combinations of these principles were studied. Aeration in the drill hole and adsorption on granulated activated char-coal were also tested. The best results, about 70 % reduction, were obtained with aeration in the pressure tank with a spray system combined with diffused air bubbling. The Oerebro project in the beginning of the 1990s included on site testing of five different aeration solutions: Aeration in the drill hole, aeration in the storage tank, ejector aeration, shallow tray aeration and packed column aeration. The radon removal efficiency varied between 20 % and 99 %. In 1994 a study intended to test the radon removal capacity of different water treatment equipment was performed. Six units of radon separators were included but most of the tested equipment was installed for other water treatment purposes. The performed measurements showed that the only types of equipment that reduce the radon concentration efficiently are radon separators and reverse osmosis filters. The radon removal capacity of the radon separators varied between 23 % and 97 %. In 1996 the nine most common radon separators on the Swedish market were tested. The results showed that the tested radon removal equipment worked well, although the technical quality and chosen technical solutions were not always the best. The radon removal capacity of the units participating in this test was in most cases between 96 and 99 %. In some cases the capacity exceeded 99 %. In order to reach this radon removal capacity the water must be recirculated in a storage tank under atmospheric pressure.

  6. Interior noise analysis of a construction equipment cabin based on airborne and structure-borne noise predictions

    International Nuclear Information System (INIS)

    Kim, Sung Hee; Hong, Suk Yoon; Song, Jee Hun; Joo, Won Ho

    2012-01-01

    Noise from construction equipment affects not only surrounding residents, but also the operators of the machines. Noise that affects drivers must be evaluated during the preliminary design stage. This paper suggests an interior noise analysis procedure for construction equipment cabins. The analysis procedure, which can be used in the preliminary design stage, was investigated for airborne and structure borne noise. The total interior noise of a cabin was predicted from the airborne noise analysis and structure-borne noise analysis. The analysis procedure consists of four steps: modeling, vibration analysis, acoustic analysis and total interior noise analysis. A mesh model of a cabin for numerical analysis was made at the modeling step. At the vibration analysis step, the mesh model was verified and modal analysis and frequency response analysis are performed. At the acoustic analysis step, the vibration results from the vibration analysis step were used as initial values for radiated noise analysis and noise reduction analysis. Finally, the total cabin interior noise was predicted using the acoustic results from the acoustic analysis step. Each step was applied to a cabin of a middle-sized excavator and verified by comparison with measured data. The cabin interior noise of a middle-sized wheel loader and a large-sized forklift were predicted using the analysis procedure of the four steps and were compared with measured data. The interior noise analysis procedure of construction equipment cabins is expected to be used during the preliminary design stage

  7. Spectrum correction algorithm for detectors in airborne radioactivity monitoring equipment NH-UAV based on a ratio processing method

    International Nuclear Information System (INIS)

    Cao, Ye; Tang, Xiao-Bin; Wang, Peng; Meng, Jia; Huang, Xi; Wen, Liang-Sheng; Chen, Da

    2015-01-01

    The unmanned aerial vehicle (UAV) radiation monitoring method plays an important role in nuclear accidents emergency. In this research, a spectrum correction algorithm about the UAV airborne radioactivity monitoring equipment NH-UAV was studied to measure the radioactive nuclides within a small area in real time and in a fixed place. The simulation spectra of the high-purity germanium (HPGe) detector and the lanthanum bromide (LaBr 3 ) detector in the equipment were obtained using the Monte Carlo technique. Spectrum correction coefficients were calculated after performing ratio processing techniques about the net peak areas between the double detectors on the detection spectrum of the LaBr 3 detector according to the accuracy of the detection spectrum of the HPGe detector. The relationship between the spectrum correction coefficient and the size of the source term was also investigated. A good linear relation exists between the spectrum correction coefficient and the corresponding energy (R 2 =0.9765). The maximum relative deviation from the real condition reduced from 1.65 to 0.035. The spectrum correction method was verified as feasible. - Highlights: • An airborne radioactivity monitoring equipment NH-UAV was developed to measure radionuclide after a nuclear accident. • A spectrum correction algorithm was proposed to obtain precise information on the detected radioactivity within a small area. • The spectrum correction method was verified as feasible. • The corresponding spectrum correction coefficients increase first and then stay constant

  8. Interior noise analysis of a construction equipment cabin based on airborne and structure-borne noise predictions

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung Hee; Hong, Suk Yoon [Seoul National University, Seoul (Korea, Republic of); Song, Jee Hun [Chonnam National University, Gwangju (Korea, Republic of); Joo, Won Ho [Hyundai Heavy Industries Co. Ltd, Ulsan (Korea, Republic of)

    2012-04-15

    Noise from construction equipment affects not only surrounding residents, but also the operators of the machines. Noise that affects drivers must be evaluated during the preliminary design stage. This paper suggests an interior noise analysis procedure for construction equipment cabins. The analysis procedure, which can be used in the preliminary design stage, was investigated for airborne and structure borne noise. The total interior noise of a cabin was predicted from the airborne noise analysis and structure-borne noise analysis. The analysis procedure consists of four steps: modeling, vibration analysis, acoustic analysis and total interior noise analysis. A mesh model of a cabin for numerical analysis was made at the modeling step. At the vibration analysis step, the mesh model was verified and modal analysis and frequency response analysis are performed. At the acoustic analysis step, the vibration results from the vibration analysis step were used as initial values for radiated noise analysis and noise reduction analysis. Finally, the total cabin interior noise was predicted using the acoustic results from the acoustic analysis step. Each step was applied to a cabin of a middle-sized excavator and verified by comparison with measured data. The cabin interior noise of a middle-sized wheel loader and a large-sized forklift were predicted using the analysis procedure of the four steps and were compared with measured data. The interior noise analysis procedure of construction equipment cabins is expected to be used during the preliminary design stage.

  9. Use of in-home stationary cycling equipment among parents in a family-based randomized trial intervention.

    Science.gov (United States)

    Rhodes, Ryan E; Beauchamp, Mark R; Blanchard, Chris M; Bredin, Shannon S D; Warburton, Darren E R; Maddison, Ralph

    2018-04-03

    The purpose of this study was to examine the use of home exercise equipment in the form of exergame cycling compared to a stationary recumbent bicycle ergometer in front of TV in the home over 3 months among parents of an intervention with their inactive children. The primary outcome was bike use (total weekly duration). Predictors of bike use in the form of theory of planned behavior and self-determination theory were also examined. Randomized controlled trial. Sixty eight parents of children aged 10-14 were randomized to either the exergame condition (n=36) or the standard bike condition (n=32). Weekly bike use was recorded in a log-book. The exergame bike and a standard bike in front of a TV had similar use across three months (p=.13, η p 2 =.02), which declined over time (pintention to use the bikes were more likely to use the bikes (p<.05). Furthermore, those who reported higher perceived control, intrinsic motivation, and affective attitude were more likely to use the bikes (p<.05). The findings suggested that irrespective of modality, use of exercise equipment declined considerably for parents over three-months. Parents may also benefit from family physical activity interventions, but it depends on their physical activity status, how much they would enjoy using the equipment, and their overall perceived control over being physically active. clinicaltrials.gov #NCT01373762. Registered 1 June 2011. Copyright © 2018 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  10. Spectrum correction algorithm for detectors in airborne radioactivity monitoring equipment NH-UAV based on a ratio processing method

    Energy Technology Data Exchange (ETDEWEB)

    Cao, Ye [Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China); Tang, Xiao-Bin, E-mail: tangxiaobin@nuaa.edu.cn [Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China); Jiangsu Key Laboratory of Nuclear Energy Equipment Materials Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China); Wang, Peng; Meng, Jia; Huang, Xi; Wen, Liang-Sheng [Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China); Chen, Da [Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China); Jiangsu Key Laboratory of Nuclear Energy Equipment Materials Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China)

    2015-10-11

    The unmanned aerial vehicle (UAV) radiation monitoring method plays an important role in nuclear accidents emergency. In this research, a spectrum correction algorithm about the UAV airborne radioactivity monitoring equipment NH-UAV was studied to measure the radioactive nuclides within a small area in real time and in a fixed place. The simulation spectra of the high-purity germanium (HPGe) detector and the lanthanum bromide (LaBr{sub 3}) detector in the equipment were obtained using the Monte Carlo technique. Spectrum correction coefficients were calculated after performing ratio processing techniques about the net peak areas between the double detectors on the detection spectrum of the LaBr{sub 3} detector according to the accuracy of the detection spectrum of the HPGe detector. The relationship between the spectrum correction coefficient and the size of the source term was also investigated. A good linear relation exists between the spectrum correction coefficient and the corresponding energy (R{sup 2}=0.9765). The maximum relative deviation from the real condition reduced from 1.65 to 0.035. The spectrum correction method was verified as feasible. - Highlights: • An airborne radioactivity monitoring equipment NH-UAV was developed to measure radionuclide after a nuclear accident. • A spectrum correction algorithm was proposed to obtain precise information on the detected radioactivity within a small area. • The spectrum correction method was verified as feasible. • The corresponding spectrum correction coefficients increase first and then stay constant.

  11. Cell therapy medicinal product regulatory framework in Europe and its application for MSC-based therapy development

    Science.gov (United States)

    Ancans, Janis

    2012-01-01

    Advanced therapy medicinal products (ATMPs), including cell therapy products, form a new class of medicines in the European Union. Since the ATMPs are at the forefront of scientific innovation in medicine, specific regulatory framework has been developed for these medicines and implemented from 2009. The Committee for Advanced Therapies (CAT) has been established at the European Medicines Agency (EMA) for centralized classification, certification and evaluation procedures, and other ATMP-related tasks. Guidance documents, initiatives, and interaction platforms are available to make the new framework more accessible for small- and medium-sized enterprises, academia, hospitals, and foundations. Good understanding of the centralized and national components of the regulatory system is required to plan product development. It is in the best interests of the cell therapy developers to utilize the resources provided starting with the pre-clinical stage. Whilst there have been no mesenchymal stem cell (MSC)-based medicine authorizations in the EU, three MSC products have received marketing approval in other regions since 2011. The information provided on the regulatory requirements, procedures, and initiatives is aimed at facilitating MSC-based medicinal product development and authorization in the EU. PMID:22912639

  12. Evaluation of Delivery Costs for External Beam Radiation Therapy and Brachytherapy for Locally Advanced Cervical Cancer Using Time-Driven Activity-Based Costing.

    Science.gov (United States)

    Bauer-Nilsen, Kristine; Hill, Colin; Trifiletti, Daniel M; Libby, Bruce; Lash, Donna H; Lain, Melody; Christodoulou, Deborah; Hodge, Constance; Showalter, Timothy N

    2018-01-01

    To evaluate the delivery costs, using time-driven activity-based costing, and reimbursement for definitive radiation therapy for locally advanced cervical cancer. Process maps were created to represent each step of the radiation treatment process and included personnel, equipment, and consumable supplies used to deliver care. Personnel were interviewed to estimate time involved to deliver care. Salary data, equipment purchasing information, and facilities costs were also obtained. We defined the capacity cost rate (CCR) for each resource and then calculated the total cost of patient care according to CCR and time for each resource. Costs were compared with 2016 Medicare reimbursement and relative value units (RVUs). The total cost of radiation therapy for cervical cancer was $12,861.68, with personnel costs constituting 49.8%. Brachytherapy cost $8610.68 (66.9% of total) and consumed 423 minutes of attending radiation oncologist time (80.0% of total). External beam radiation therapy cost $4055.01 (31.5% of total). Personnel costs were higher for brachytherapy than for the sum of simulation and external beam radiation therapy delivery ($4798.73 vs $1404.72). A full radiation therapy course provides radiation oncologists 149.77 RVUs with intensity modulated radiation therapy or 135.90 RVUs with 3-dimensional conformal radiation therapy, with total reimbursement of $23,321.71 and $16,071.90, respectively. Attending time per RVU is approximately 4-fold higher for brachytherapy (5.68 minutes) than 3-dimensional conformal radiation therapy (1.63 minutes) or intensity modulated radiation therapy (1.32 minutes). Time-driven activity-based costing was used to calculate the total cost of definitive radiation therapy for cervical cancer, revealing that brachytherapy delivery and personnel resources constituted the majority of costs. However, current reimbursement policy does not reflect the increased attending physician effort and delivery costs of brachytherapy. We

  13. Recent advances in cell-based therapy for Parkinson disease

    DEFF Research Database (Denmark)

    Astradsson, Arnar; Cooper, Oliver; Vinuela, Angel

    2008-01-01

    In this review, the authors discuss recent advances in the field of cell therapy for Parkinson disease (PD). They compare and contrast recent clinical trials using fetal dopaminergic neurons. They attribute differences in cell preparation techniques, cell type specification, and immunosuppression...

  14. Evidence based practice and techniques in aquatic therapy for ...

    African Journals Online (AJOL)

    Aquatic therapy (AT) is a holistic method of treatment that involves activity or passive activity to produce healthcare outcomes. The push for holistic treatment in rehabilitation is emphasized by the World Health Organization (WHO) (2009). The WHO suggested that healthcare organizations should turn their attention from ...

  15. Antibody-Based Cancer Therapy : Successful Agents and Novel Approaches

    NARCIS (Netherlands)

    Hendriks, D; Choi, G; de Bruyn, M; Wiersma, V R; Bremer, E; Galluzi, Lorenzo; Vitale, Ilio

    2017-01-01

    Since their discovery, antibodies have been viewed as ideal candidates or "magic bullets" for use in targeted therapy in the fields of cancer, autoimmunity, and chronic inflammatory disorders. A wave of antibody-dedicated research followed, which resulted in the clinical approval of a first

  16. Performative, Arts-Based, or Arts-Informed? Reflections on the Development of Arts-Based Research in Music Therapy.

    Science.gov (United States)

    Ledger, Alison; McCaffrey, Tríona

    2015-01-01

    Arts-based research (ABR) has emerged in music therapy in diverse ways, employing a range of interpretive paradigms and artistic media. It is notable that no consensus exists as to when and where the arts are included in the research process, or which music therapy topics are most suited to arts-based study. This diversity may pose challenges for music therapists who are developing, reading, and evaluating arts-based research. This paper provides an updated review of arts-based research literature in music therapy, along with four questions for researchers who are developing arts-based research. These questions are 1) When should the arts be introduced? 2) Which artistic medium is appropriate? 3) How should the art be understood? and 4) What is the role of the audience? We argue that these questions are key to understanding arts-based research, justifying methods, and evaluating claims arising from arts-based research. Rather than defining arts-based research in music therapy, we suggest that arts-based research should be understood as a flexible research strategy appropriate for exploring the complexities of music therapy practice. © the American Music Therapy Association 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  17. Generation of equipment response spectrum considering equipment-structure interaction

    International Nuclear Information System (INIS)

    Lee, Sang Hoon; Yoo, Kwang Hoon

    2005-01-01

    Floor response spectra for dynamic response of subsystem such as equipment, or piping in nuclear power plant are usually generated without considering dynamic interaction between main structure and subsystem. Since the dynamic structural response generally has the narrow-banded shapes, the resulting floor response spectra developed for various locations in the structure usually have high spectral peak amplitudes in the narrow frequency bands corresponding to the natural frequencies of the structural system. The application of such spectra for design of subsystems often leads to excessive design conservatisms, especially when the equipment frequency and structure are at resonance condition. Thus, in order to provide a rational and realistic design input for dynamic analysis and design of equipment, dynamic equipment-structure interaction (ESI) should be considered in developing equipment response spectrum which is particularly important for equipment at the resonance condition. Many analytical methods have been proposed in the past for developing equipment response spectra considering ESI. However, most of these methods have not been adapted to the practical applications because of either the complexities or the lack of rigorousness of the methods. At one hand, mass ratio among the equipment and structure was used as an important parameter to obtain equipment response spectra. Similarly, Tseng has also proposed the analytical method for developing equipment response spectra using mass ratio in the frequency domain. This method is analytically rigorous and can be easily validated. It is based on the dynamic substructuring method as applied to the dynamic soil-structure interaction (SSI) analysis, and can relatively easily be implemented for practical applications without to change the current dynamic analysis and design practice for subsystems. The equipment response spectra derived in this study are also based on Tseng's proposed method

  18. The improvement of KINR NASU experimental base and methods of nondestructive control of functional characteristics of nuclear power stations' equipment and materials

    International Nuclear Information System (INIS)

    Kovalinska, T.V.; Ostapenko, I.A.; Sakhno, V.I.; Zelinskyy, A.G.

    2012-01-01

    The ways of the improvement of technical base of the INR of NAS of Ukraine for functional researches, and new technologies of control over the state of the equipment on NPPs are discussed. The scientific work is completed in the department of radiation technologies within the national program of the enhancement of the reliability of nuclear energetic and the prolongation of exploitation terms of nuclear power installations

  19. Selection of equipment for equipment qualification

    International Nuclear Information System (INIS)

    Torr, K.G.

    1989-01-01

    This report describes the methodology applied in selecting equipment in the special safety systems for equipment qualification in the CANDU 600 MW nuclear generating stations at Gentilly 2 and Point Lepreau. Included is an explanation of the selection procedure adopted and the rationale behind the criteria used in identifying the equipment. The equipment items on the list have been grouped into three priority categories as a planning aid to AECB staff for a review of the qualification status of the special safety systems

  20. Solution-Focused Therapy: Strength-Based Counseling for Children with Social Phobia

    Science.gov (United States)

    George, Cindy M.

    2008-01-01

    Solution-focused therapy is proposed as an effective strength-based model for children with social phobia. Social phobia is described along with the etiology and prevailing treatment approaches. A case illustration demonstrates the application of solution-focused therapy with a child who experienced social phobia. Implications for counseling and…

  1. Mindfulness-based cognitive therapy for seasonal affective disorder : A pilot study

    NARCIS (Netherlands)

    Fleer, Joke; Schroevers, Maya; Panjer, Vera; Geerts, Erwin; Meesters, Ybe

    2014-01-01

    Background: The best available treatment for seasonal affective disorder (SAD) is light therapy. Yet, this treatment does not prevent recurrence of depression in subsequent seasons. The aim of the study is to gain preliminary insight in the efficacy of Mindfulness Based Cognitive Therapy (MBCT) in

  2. Is Bobath-based therapy used by physiotherapists in the care of stroke patients?

    NARCIS (Netherlands)

    Nico L.U. Meeteren; Maria H.F. Grypdonck; Thóra Hafsteinsdóttir

    2005-01-01

    The aim of this study was to investigate if physiotherapists had knowledge and skills in applying Bobath-based therapy (BB), also referred to as Neurodevelopmental Treatment, in the care of stroke patients and if they generally used the therapy in daily practice. This is because of the important

  3. Effect of health education based on BASNEF pattern on use of personal protective respiratory equipment in Ahvaz carbon block factory workers, 2009

    Directory of Open Access Journals (Sweden)

    M Solhi

    2012-11-01

    Full Text Available   Background and aims: Respiratory diseases due to work with 50 million annually incidence included one third of all occupational diseases and it is one of the main causes of absenteeism from work in workers. Some occupational diseases can be prevented with personal protective equipment. BASNEF model is one of the effective health education and safety training models for workers. The aim of this study was to determine the effect of educational intervention based on BASNEF pattern on increasing the use of personal protective respiratory equipment among carbon black factory workers , where many air pollutants such as carbon block exists. Methods: In this study the intervention curriculum based on BASNEF pattern administrated on 100 (experimental and control Ahvaz carbon block factory workers. Data were collected by questionnaires. The data were analyzed by Independent T, χ square and Pearson correlation co- efficient using SPSS version16.   Results : After the intervention, the mean scores of knowledge, attitude, intention, and enabling factors showed significant increase in experimental group in comparison of control group (p<0.00001. In addition, the mean score of subjective norms in experimental and control groups showed no significant differences. Conclusion: The educational program based on BASNEF pattern was effective in improving the use of respiratory personal protective equipment in Ahvaz carbon block factory workers 

  4. Topical therapies in the management of chronic rhinosinusitis: an evidence-based review with recommendations.

    Science.gov (United States)

    Rudmik, Luke; Hoy, Monica; Schlosser, Rodney J; Harvey, Richard J; Welch, Kevin C; Lund, Valerie; Smith, Timothy L

    2013-04-01

    Topical therapies have become an integral component in the management plan for chronic rhinosinusitis (CRS). Several topical therapy strategies have been evaluated, but a formal comprehensive evaluation of the evidence has never been performed. The purpose of this article is to provide an evidence-based approach for the utilization of topical therapies in the management of CRS. A systematic review of the literature was performed and the guidelines for development of an evidence-based review with recommendations were followed. Study inclusion criteria were: adult population >18 years old; chronic rhinosinusitis (CRS) based on published diagnostic criteria; and clearly defined primary clinical end-point. We focused on reporting higher-quality studies (level 2b or higher), but reported on lower-level studies if the topic contained insufficient evidence. We excluded drug-eluting spacer and stent therapy from this review. This review identified and evaluated the literature on 5 topical therapy strategies for CRS: saline irrigation, topical steroid, topical antibiotic, topical antifungal, and topical alternatives (surfactant, manuka honey, and xylitol irrigations). Based on the available evidence, sinonasal saline irrigation and standard topical nasal steroid therapy are recommended in the topical treatment of CRS. Nonstandard (off-label) topical sinonasal steroid therapies can be an option for managing CRS. The evidence recommends against the use of topical antifungal therapy and topical antibiotic therapy delivered using nebulized and spray techniques in routine cases of CRS. There is insufficient clinical research to provide recommendations for alternative therapies or topical antibiotic therapy delivered using other delivery methods (eg, irrigations). © 2013 ARS-AAOA, LLC.

  5. Mesenchymal Stem Cell-Based Tumor-Targeted Gene Therapy in Gastrointestinal Cancer

    Science.gov (United States)

    Bao, Qi; Zhao, Yue; Niess, Hanno; Conrad, Claudius; Schwarz, Bettina; Jauch, Karl-Walter; Huss, Ralf; Nelson, Peter J.

    2012-01-01

    Mesenchymal stem (or stromal) cells (MSCs) are nonhematopoietic progenitor cells that can be obtained from bone marrow aspirates or adipose tissue, expanded and genetically modified in vitro, and then used for cancer therapeutic strategies in vivo. Here, we review available data regarding the application of MSC-based tumor-targeted therapy in gastrointestinal cancer, provide an overview of the general history of MSC-based gene therapy in cancer research, and discuss potential problems associated with the utility of MSC-based therapy such as biosafety, immunoprivilege, transfection methods, and distribution in the host. PMID:22530882

  6. Possible artemisinin-based combination therapy-resistant malaria in Nigeria: a report of three cases

    Directory of Open Access Journals (Sweden)

    Nnennaya Anthony Ajayi

    2013-07-01

    Full Text Available Artemisinin-based combination therapy-resistant malaria is rare in Sub-Saharan Africa. The World Health Organization identifies monitoring and surveillance using day-3 parasitaemia post-treatment as the standard test for identifying suspected artemisinin resistance. We report three cases of early treatment failure due to possible artemisinin-based combination therapy-resistant Plasmodium falciparum malaria. All cases showed adequate clinical and parasitological responses to quinine. This study reveals a need to re-evaluate the quality and efficacy of artemisinin-based combination therapy agents in Nigeria and Sub-Saharan Africa.

  7. Medical equipment archives management based on internet%基于互联网的医疗器械档案管理

    Institute of Scientific and Technical Information of China (English)

    杨琼

    2017-01-01

    目的:有效管理医疗器械档案,实现档案信息资源的共享.方法:通过互联网管理平台与内网相结合的多途径、多渠道管理模式,根据医疗设备和医用耗材档案管理的不同需求进行分类管理.结果:销售公司作为用户参与到医院管理工作中来,充分发挥了他们的主观能动性,有效减轻了设备科的工作压力;工作人员可以随时随地登录网站查阅、录入信息,为工作提供方便,实现了医疗器械电子档案精确动态管理.结论:医疗器械档案管理网络化是档案收集及充分发挥档案作用的一个有效途径.%Objective To effectively manage the archives of medical equipment and realize the sharing of archives information resources.Methods Multi-way management mode integrating internet management platform and intranet was involved in classification management according to the requirements of medical equipment and consumables archives management.Results Distribution company was involved in hospital management as the user,and the workload of the equipment department was relieved effectively.The staff could inquire and input information by logging in the website,and precision and dynamic management of medical equipment electronic archives was realized.Conclusion Network-based medical equipment archives management contributes to the collection and application of the archives.

  8. Comparison of Medical and Voice Therapy for reflux Laryngitis Based on Acoustic and Laryngeal Characteristics

    Directory of Open Access Journals (Sweden)

    Abbas Dehestani Ardakani

    2011-12-01

    Full Text Available Background and Aim: Reflux laryngitis is extremely common among patients with voice disorder. Medical therapy approaches are not efficient enough. The main goal of this study is to assess the acoustic and laryngeal characteristics of patients with dysphonia before and after medical or voice therapy, and to evaluate the effectiveness of each.Methods: In this retrospective study, 16 reflux laryngitis patients were assessed. Five received complete voice therapy, tow ceased voice therapy and nine received medication. Perceptual voice evaluation was performed by a speech-language pathologist, the severity of voice problem was calculated, based on the affected acoustic and laryngeal characteristics pre- and post-treatment.Results: Post-treatment evaluation in patients who received complete voice therapy indicates 80 percent improvement in the severity of disorder and 100 percent improvement in the perceptual voice evaluation. After medical therapy, we observed that voice disorder and perceptual voice evaluation are improved 44 and 66 percent respectively. The improvement was statistically significant in both treatment approaches: complete voice therapy (P=0.039 and medical therapy (p=0.017.Conclusion: In patients with reflux laryngitis, most acoustic and laryngeal characteristics were normal and satisfying after the treatment. It can be concluded that the proficiency of voice therapy in improving the acoustic and laryngeal characteristics is comparable to medical therapy

  9. Erosion of wind turbine blade coatings - Design and analysis of jet-based laboratory equipment for performance evaluation

    DEFF Research Database (Denmark)

    Zhang, Shizhong; Dam-Johansen, Kim; Nørkjær, Sten

    2015-01-01

    of the blades in such equipment. To reduce expensive blade maintenance repairs and to avoid out-of-service periods, energy-absorbing blade coatings are required to protect rotor blades from rain erosion. In this work we describe the design, construction and evaluation of a laboratory setup for fast screening...... experimental blade coatings were investigated using the proposed experimental design. The evaluation of the coatings under conditions where impact frequency and water hammer pressure were "matched" could not be directly correlated with the results obtained with the whirling arm rig. This result may...

  10. Optimal Active Power Control of A Wind Farm Equipped with Energy Storage System based on Distributed Model Predictive Control

    DEFF Research Database (Denmark)

    Zhao, Haoran; Wu, Qiuwei; Guo, Qinglai

    2016-01-01

    This paper presents the Distributed Model Predictive Control (D-MPC) of a wind farm equipped with fast and short-term Energy Storage System (ESS) for optimal active power control using the fast gradient method via dual decomposition. The primary objective of the D-MPC control of the wind farm...... is power reference tracking from system operators. Besides, by optimal distribution of the power references to individual wind turbines and the ESS unit, the wind turbine mechanical loads are alleviated. With the fast gradient method, the convergence rate of the DMPC is significantly improved which leads...

  11. Microsponges based novel drug delivery system for augmented arthritis therapy

    OpenAIRE

    Osmani, Riyaz Ali M.; Aloorkar, Nagesh H.; Ingale, Dipti J.; Kulkarni, Parthasarathi K.; Hani, Umme; Bhosale, Rohit R.; Jayachandra Dev, Dandasi

    2015-01-01

    The motive behind present work was to formulate and evaluate gel containing microsponges of diclofenac diethylamine to provide prolonged release for proficient arthritis therapy. Quasi-emulsion solvent diffusion method was implied using Eudragit RS-100 and microsponges with varied drug–polymer ratios were prepared. For the sake of optimization, diverse factors affecting microparticles physical properties were too investigated. Microsponges were characterized by SEM, DSC, FT-IR, XRPD and parti...

  12. TOPICAL REVIEW: Stem cells engineering for cell-based therapy

    Science.gov (United States)

    Taupin, Philippe

    2007-09-01

    Stem cells carry the promise to cure a broad range of diseases and injuries, from diabetes, heart and muscular diseases, to neurological diseases, disorders and injuries. Significant progresses have been made in stem cell research over the past decade; the derivation of embryonic stem cells (ESCs) from human tissues, the development of cloning technology by somatic cell nuclear transfer (SCNT) and the confirmation that neurogenesis occurs in the adult mammalian brain and that neural stem cells (NSCs) reside in the adult central nervous system (CNS), including that of humans. Despite these advances, there may be decades before stem cell research will translate into therapy. Stem cell research is also subject to ethical and political debates, controversies and legislation, which slow its progress. Cell engineering has proven successful in bringing genetic research to therapy. In this review, I will review, in two examples, how investigators are applying cell engineering to stem cell biology to circumvent stem cells' ethical and political constraints and bolster stem cell research and therapy.

  13. Stem cells engineering for cell-based therapy.

    Science.gov (United States)

    Taupin, Philippe

    2007-09-01

    Stem cells carry the promise to cure a broad range of diseases and injuries, from diabetes, heart and muscular diseases, to neurological diseases, disorders and injuries. Significant progresses have been made in stem cell research over the past decade; the derivation of embryonic stem cells (ESCs) from human tissues, the development of cloning technology by somatic cell nuclear transfer (SCNT) and the confirmation that neurogenesis occurs in the adult mammalian brain and that neural stem cells (NSCs) reside in the adult central nervous system (CNS), including that of humans. Despite these advances, there may be decades before stem cell research will translate into therapy. Stem cell research is also subject to ethical and political debates, controversies and legislation, which slow its progress. Cell engineering has proven successful in bringing genetic research to therapy. In this review, I will review, in two examples, how investigators are applying cell engineering to stem cell biology to circumvent stem cells' ethical and political constraints and bolster stem cell research and therapy.

  14. [Analysis and evaluation of the visual effort in remote-control public traffic operators working with computer-based equipments].

    Science.gov (United States)

    Gullà, F; Zambelli, P; Bergamaschi, A; Piccoli, B

    2007-01-01

    The aim of this study is the objective evaluation of the visual effort in 6 public traffic controllers (4 male, 2 female, mean age 29,6), by means of electronic equipment. The electronic equipment quantify the observation distance and the observation time for each controller's occupational visual field. The quantification of these parameters is obtained by the emission of ultrasound at 40 KHz from an emission sensor (placed by the VDT screen) and the ultrasound reception by means of a receiving sensor (placed on the operator's head). The travelling time of the ultrasound (US), as the air speed is known and costant (about 340 m/s), it is used to calculate the distance between the emitting and the receiving sensor. The results show that the visual acuity required is of average level, while accommodation's and convergence's effort vary from average to intense (depending on the visual characteristics of the operator considered), ranging from 26,41 and 43,92% of accommodation and convergence available in each operator. The time actually spent in "near observation within the c.v.p." (Tscr) was maintained in a range from 2h 54' and 4h 05'.

  15. Assessing the impact of space weather on the electric power grid based on insurance claims for industrial electrical equipment

    Science.gov (United States)

    Schrijver, C. J.; Dobbins, R.; Murtagh, W.; Petrinec, S. M.

    2014-07-01

    Geomagnetically induced currents are known to induce disturbances in the electric power grid. Here we perform a statistical analysis of 11,242 insurance claims from 2000 through 2010 for equipment losses and related business interruptions in North American commercial organizations that are associated with damage to, or malfunction of, electrical and electronic equipment. We find that claim rates are elevated on days with elevated geomagnetic activity by approximately 20% for the top 5% and by about 10% for the top third of most active days ranked by daily maximum variability of the geomagnetic field. When focusing on the claims explicitly attributed to electrical surges (amounting to more than half the total sample), we find that the dependence of claim rates on geomagnetic activity mirrors that of major disturbances in the U.S. high-voltage electric power grid. The claim statistics thus reveal that large-scale geomagnetic variability couples into the low-voltage power distribution network and that related power-quality variations can cause malfunctions and failures in electrical and electronic devices that, in turn, lead to an estimated 500 claims per average year within North America. We discuss the possible magnitude of the full economic impact associated with quality variations in electrical power associated with space weather.

  16. Effects of Group Counseling Based on Logo Therapy to Decrease Loneliness in Elderly Men

    Directory of Open Access Journals (Sweden)

    Negin Yazdanbakhsh

    2016-10-01

    Conclusion Group counseling based on logo therapy was found to decrease loneliness scores of elderly men. Therefore, the approach taken in this study can be considered as an appropriate method for psychological interventions in elderly men.

  17. Mesenchymal Stem Cell-Based Tumor-Targeted Gene Therapy in Gastrointestinal Cancer

    OpenAIRE

    Bao, Qi; Zhao, Yue; Niess, Hanno; Conrad, Claudius; Schwarz, Bettina; Jauch, Karl-Walter; Huss, Ralf; Nelson, Peter J.; Bruns, Christiane J.

    2012-01-01

    Mesenchymal stem (or stromal) cells (MSCs) are nonhematopoietic progenitor cells that can be obtained from bone marrow aspirates or adipose tissue, expanded and genetically modified in vitro, and then used for cancer therapeutic strategies in vivo. Here, we review available data regarding the application of MSC-based tumor-targeted therapy in gastrointestinal cancer, provide an overview of the general history of MSC-based gene therapy in cancer research, and discuss potential problems associa...

  18. Behavior Therapy for Tic Disorders: An Evidenced-based Review and New Directions for Treatment Research

    OpenAIRE

    McGuire, Joseph F.; Ricketts, Emily J.; Piacentini, John; Murphy, Tanya K.; Storch, Eric A.; Lewin, Adam B.

    2015-01-01

    Behavior therapy is an evidenced-based intervention with moderate-to-large treatment effects in reducing tic symptom severity among individuals with Persistent Tic Disorders (PTDs) and Tourette’s Disorder (TD). This review describes the behavioral treatment model for tics, delineates components of evidence-based behavior therapy for tics, and reviews the empirical support among randomized controlled trials for individuals with PTDs or TD. Additionally, this review discusses several challenges...

  19. Porphyrin-based Nanostructure-Dependent Photodynamic and Photothermal Therapies

    Science.gov (United States)

    Jin, Cheng S.

    This thesis presents the investigation of nanostructure-dependent phototherapy. We reviewed the liposomal structures for delivery of photosensitizers, and introduced a novel class of phototransducing liposomes called "porphysomes". Porphysomes are self-assembled from high packing density of pyropheophorbide alpha-conjugated phospholipids, resulting in extreme self-quenching of porphyrin fluorescence and comparable optical absorption to gold nanoparticles for high photothermal efficiency. We demonstrated this self-assembly of porphyrin-lipid conjugates converts a singlet oxygen generating mechanism (photodynamic therapy PDT activity) of porphyrin to photothermal mechanism (photothermal therapy PTT activity). The efficacy of porphysome-enhanced PTT was then evaluated on two pre-clinical animal models. We validated porphysome-enabled focal PTT to treat orthotopic prostate cancer using MRI-guided focal laser placement to closely mimic the current clinic procedure. Furthermore, porphysome-enabled fluorescence-guided transbronchial PTT of lung cancer was demonstrated in rabbit orthotopic lung cancer models, which led to the development of an ultra-minimally invasive therapy for early-stage peripheral lung cancer. On the other hand, the nanostructure-mediated conversion of PDT to PTT can be switched back by nanoparticle dissociation. By incorporating folate-conjugated phospholipids into the formulation, porphysomes were internalized into cells rapidly via folate receptor-mediated endocytosis and resulted in efficient disruption of nanostructures, which turned back on the photodynamic activity of densely packed porphyrins, making a closed loop of conversion between PDT and PTT. The multimodal imaging and therapeutic features of porphysome make it ideal for future personalized cancer treatments.

  20. Exposure-Based Therapy for Symptom Preoccupation in Atrial Fibrillation

    DEFF Research Database (Denmark)

    Särnholm, Josefin; Skúladóttir, Helga; Rück, Christian

    2017-01-01

    Atrial fibrillation (AF) is the most common cardiac arrhythmia. Patients often experience a range of symptoms resulting in a markedly reduced quality of life, and commonly show symptom preoccupation in terms of avoidance and control behaviors. Cognitive behavior therapy (CBT) has been shown...... with symptomatic paroxysmal (intermittent) atrial fibrillation who were assessed pre- and posttreatment and at 6-month follow-up. The CBT lasted 10 weeks and included exposure to physical sensations similar to AF symptoms, exposure to avoided situations or activities, and behavioral activation. We observed large...

  1. Rejuvenating Strategies for Stem Cell-based Therapies in Aging

    Science.gov (United States)

    Neves, Joana; Sousa-Victor, Pedro; Jasper, Heinrich

    2017-01-01

    SUMMARY Recent advances in our understanding of tissue regeneration and the development of efficient approaches to induce and differentiate pluripotent stem cells for cell replacement therapies promise exciting avenues for treating degenerative age-related diseases. However, clinical studies and insights from model organisms have identified major roadblocks that normal aging processes impose on tissue regeneration. These new insights suggest that specific targeting of environmental niche components, including growth factors, ECM and immune cells, and intrinsic stem cell properties that are affected by aging will be critical for development of new strategies to improve stem cell function and optimize tissue repair processes. PMID:28157498

  2. Maternal deaths following nevirapine-based antiretroviral therapy

    Directory of Open Access Journals (Sweden)

    E Bera

    2012-10-01

    Full Text Available We report 2 cases illustrating that it is too simplistic to link nevirapine (NVP toxicity exclusively to individuals with immune preservation. Not enough is known about the mechanism of hepatotoxicity or cutaneous eruption to predict these events. This type of hypersensitivity reaction occurs rarely among HIV-exposed infants taking NVP prophylaxis or antiretroviral therapy (ART-experienced adults with complete plasma viral load suppression. Conversely, HIV-uninfected adults and ART-naive pregnant women appear to be disproportionately affected by the adverse effects of NVP.

  3. Information technology equipment cooling method

    Science.gov (United States)

    Schultz, Mark D.

    2015-10-20

    According to one embodiment, a system for removing heat from a rack of information technology equipment may include a sidecar indoor air to liquid heat exchanger that cools air utilized by the rack of information technology equipment to cool the rack of information technology equipment. The system may also include a liquid to liquid heat exchanger and an outdoor heat exchanger. The system may further include configurable pathways to connect and control fluid flow through the sidecar heat exchanger, the liquid to liquid heat exchanger, the rack of information technology equipment, and the outdoor heat exchanger based upon ambient temperature and/or ambient humidity to remove heat generated by the rack of information technology equipment.

  4. Incretin-based therapies for type 2 diabetes mellitus in Asian patients: Analysis of clinical trials

    Directory of Open Access Journals (Sweden)

    Melva Louisa

    2010-08-01

    Full Text Available Aim To review the effi cacy and safety data on incretin-based therapies currently available (exenatide, liraglutide, sitagliptin, vildagliptin for the treatment of type 2 diabetes mellitus in Asian population.Methods We conducted Medline search of all relevant randomized clinical trials of incretin-based therapies for type 2 diabetes mellitus in Asian populations. Data pertinent to the efficacy and safety of GLP-1 mimetics and DPP-4 inhibitors were extracted and used.Results We found 14 randomized controlled trials of incretin based-therapy which included 3567 type 2 diabetes mellitus in Asian population (Japanese, Chinese, Korean, Indian. It was shown that incretin-based therapies improved HbA1c at higher extent (up to -1.42% in exenatide 10 mcg bid, -1.85% for liraglutide 0.9 mg qd, -1.4% for sitagliptin 100 mg and -1.4% for vildagliptin 50 mg bid compared to the effects observed in studies with Caucasian population, with comparable safety profile.Conclusion The efficacy of incretin-based therapies in Asian patients improved glycemic parameters in a higher magnitude on some glycemic parameters compared with those in Caucasian population. These results indicate that incretin-based therapies may be more effective in Asian population than in Caucasian. (Med J Indones 2010; 19: 205-12Key words: exenatide, incretin, liraglutide, sitagliptin, type-2 diabetes, vildagliptin

  5. An experimental evaluation of powder flow predictions in small-scale process equipment based on Jenike's hopper design methodology

    DEFF Research Database (Denmark)

    Søgaard, Søren Vinter; Olesen, Niels Erik; Hirschberg, Cosima

    2017-01-01

    . The comparison of the observed and predicted critical outlet diameters showed good agreement for the powder with the best flowability when linear extrapolation of the flow function was applied. In contrast, the predicted critical outlet diameter was slightly overestimated compared to the experimentally observed...... diameter for the two more cohesive powders. A likely reason for this overestimation is that the flow function probably has a non-linear convex upward shape for these two powders at very small consolidation stresses. These findings illustrate the relevance of measuring shear and wall shear stresses at very...... small consolidation stresses to improve the flow behavior predictions for small-scale process equipment typically used during production of solid state pharmaceuticals....

  6. Brain Injury After Proton Therapy or Carbon Ion Therapy for Head-and-Neck Cancer and Skull Base Tumors

    International Nuclear Information System (INIS)

    Miyawaki, Daisuke; Murakami, Masao; Demizu, Yusuke; Sasaki, Ryohei; Niwa, Yasue; Terashima, Kazuki; Nishimura, Hideki; Hishikawa, Yoshio; Sugimura, Kazuro

    2009-01-01

    Purpose: To assess the incidence of early delayed or late morbidity of Brain after particle therapy for skull base tumors and head-and-neck cancers. Methods and Materials: Between May 2001 and December 2005, 59 patients with cancerous invasion of the skull base were treated with proton or carbon ion therapy at the Hyogo Ion Beam Medical Center. Adverse events were assessed according to the magnetic resonance imaging findings (late effects of normal tissue-subjective, objective, management, analytic [LENT-SOMA]) and symptoms (Common Terminology Criteria for Adverse Events [CTCAE], version 3.0). Dose-volume histograms were used to analyze the relationship between the dose and volume of the irradiated brain and the occurrence of brain injury. The median follow-up time was 33 months. Results: Of the 48 patients treated with proton therapy and 11 patients treated with carbon ion radiotherapy, 8 (17%) and 7 (64%), respectively, developed radiation-induced brain changes (RIBCs) on magnetic resonance imaging (LENT-SOMA Grade 1-3). Four patients (7%) had some clinical symptoms, such as vertigo and headache (CTCAE Grade 2) or epilepsy (CTCAE Grade 3). The actuarial occurrence rate of RIBCs at 2 and 3 years was 20% and 39%, respectively, with a significant difference in the incidence between the proton and carbon ion radiotherapy groups. The dose-volume histogram analyses revealed significant differences between Brain lobes with and without RIBCs in the actuarial volume of brain lobes receiving high doses. Conclusion: Particle therapies produced minimal symptomatic brain toxicities, but sequential evaluation with magnetic resonance imaging detected a greater incidence of RIBCs. Significant differences were observed in the irradiated brain volume between Brain lobes with and without RIBCs.

  7. Gene mutation-based and specific therapies in precision medicine.

    Science.gov (United States)

    Wang, Xiangdong

    2016-04-01

    Precision medicine has been initiated and gains more and more attention from preclinical and clinical scientists. A number of key elements or critical parts in precision medicine have been described and emphasized to establish a systems understanding of precision medicine. The principle of precision medicine is to treat patients on the basis of genetic alterations after gene mutations are identified, although questions and challenges still remain before clinical application. Therapeutic strategies of precision medicine should be considered according to gene mutation, after biological and functional mechanisms of mutated gene expression or epigenetics, or the correspondent protein, are clearly validated. It is time to explore and develop a strategy to target and correct mutated genes by direct elimination, restoration, correction or repair of mutated sequences/genes. Nevertheless, there are still numerous challenges to integrating widespread genomic testing into individual cancer therapies and into decision making for one or another treatment. There are wide-ranging and complex issues to be solved before precision medicine becomes clinical reality. Thus, the precision medicine can be considered as an extension and part of clinical and translational medicine, a new alternative of clinical therapies and strategies, and have an important impact on disease cures and patient prognoses. © 2015 The Author. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  8. Cardiac tissue engineering and regeneration using cell-based therapy

    Directory of Open Access Journals (Sweden)

    Alrefai MT

    2015-05-01

    Full Text Available Mohammad T Alrefai,1–3 Divya Murali,4 Arghya Paul,4 Khalid M Ridwan,1,2 John M Connell,1,2 Dominique Shum-Tim1,2 1Division of Cardiac Surgery, 2Division of Surgical Research, McGill University Health Center, Montreal, QC, Canada; 3King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia; 4Department of Chemical and Petroleum Engineering, School of Engineering, University of Kansas, Lawrence, KS, USA Abstract: Stem cell therapy and tissue engineering represent a forefront of current research in the treatment of heart disease. With these technologies, advancements are being made into therapies for acute ischemic myocardial injury and chronic, otherwise nonreversible, myocardial failure. The current clinical management of cardiac ischemia deals with reestablishing perfusion to the heart but not dealing with the irreversible damage caused by the occlusion or stenosis of the supplying vessels. The applications of these new technologies are not yet fully established as part of the management of cardiac diseases but will become so in the near future. The discussion presented here reviews some of the pioneering works at this new frontier. Key results of allogeneic and autologous stem cell trials are presented, including the use of embryonic, bone marrow-derived, adipose-derived, and resident cardiac stem cells. Keywords: stem cells, cardiomyocytes, cardiac surgery, heart failure, myocardial ischemia, heart, scaffolds, organoids, cell sheet and tissue engineering

  9. Third-wave cognitive therapy versus mentalisation-based treatment for major depressive disorder

    DEFF Research Database (Denmark)

    Jakobsen, Janus Christian; Gluud, Christian; Kongerslev, Mickey

    2014-01-01

    OBJECTIVE: To compare the benefits and harms of third-wave cognitive therapy versus mentalisation-based therapy in a small sample of depressed participants. SETTING: The trial was conducted at an outpatient psychiatric clinic for non-psychotic patients in Roskilde, Denmark. PARTICIPANTS: 44...... consecutive adult participants diagnosed with major depressive disorder. INTERVENTIONS: 18 weeks of third-wave cognitive therapy (n=22) versus 18 weeks of mentalisation-based treatment (n=22). OUTCOMES: The primary outcome was the Hamilton Rating Scale for Depression (HDRS) at end of treatment (18 weeks...... for baseline HDRS score, the difference was favouring third-wave cognitive therapy (p=0.039). At 18 weeks, five of the third-wave participants (22.7%) were in remission versus none of the mentalisation-based participants (p=0.049). We recorded no suicide attempts or suicides during the intervention period...

  10. An Exploration of the Role of Occupation in School-Based Occupational Therapy Practice

    Science.gov (United States)

    Benson, Jeryl DiSanti

    2010-01-01

    The purpose of this study was to explore the role of occupation in school-based occupational therapy practice. The research questions were (1) How do school-based occupational therapists describe the role of occupation during intervention? (2) Which theories of occupation do school-based occupational therapists associate with their own practice?…

  11. Promoting the Role of Occupational Therapy in School-Based Collaboration: Outcome Project

    Science.gov (United States)

    Christner, Andrea

    2015-01-01

    This evidence-based project provided a professional development opportunity for educators to enhance the awareness of school-based occupational therapy and promote a collaborative approach when supporting student participation in daily learning tasks. Through asynchronous web-based delivery, participants viewed five narrated PowerPoint…

  12. Current status of lectin-based cancer diagnosis and therapy

    Directory of Open Access Journals (Sweden)

    Fohona S. Coulibaly

    2017-01-01

    Full Text Available Lectins are carbohydrate recognizing proteins originating from diverse origins in nature, including animals, plants, viruses, bacteria and fungus. Due to their exceptional glycan recognition property, they have found many applications in analytical chemistry, biotechnology and surface chemistry. This manuscript explores the current use of lectins for cancer diagnosis and therapy. Moreover, novel drug delivery strategies aiming at improving lectin’s stability, reducing their undesired toxicity and controlling their non-specific binding interactions are discussed. We also explore the nanotechnology application of lectins for cancer targeting and imaging. Although many investigations are being conducted in the field of lectinology, there is still a limited clinical translation of the major findings reported due to lectins stability and toxicity concerns. Therefore, new investigations of safe and effective drug delivery system strategies for lectins are warranted in order to take full advantage of these proteins.

  13. Preoperative gemcitabine-based chemoradiation therapy for resectable pancreatic cancer

    International Nuclear Information System (INIS)

    Takahashi, Hidenori; Ohigashi, Hiroaki; Goto, Kunihito; Marubashi, Shigeru; Yano, Masahiko; Ishikawa, Osamu

    2013-01-01

    During the period from 2002 to 2011, a total of 240 consecutive patients with resectable pancreatic cancer received preoperative chemoradiation therapy (CRT). Among 240 patients, 201 patients underwent the subsequent pancreatectomy (resection rate: 84%). The 5-year overall survival of resected cases was 56% and the median survival of 39 unresected cases was 11 months. The 5-year locoregional recurrence rate of resected cases was 15%. The 5-year overall survival of the entire cohort (n=240) was 47%. The preoperative CRT and subsequent pancreatectomy provided a favorable surgical result, which was contributed by several characteristics of preoperative CRT: the prominent locoregional treatment effect with lower incidence of locoregional recurrence, and the discrimination between patients who are likely to benefit from subsequent surgery and those who are not. (author)

  14. Intricacies of Feedback in Computer-based Prism Adaptation Therapy

    DEFF Research Database (Denmark)

    Wilms, Inge Linda; Rytter, Hana Malá

    Prism Adaptation Therapy (PAT) is an intervention method for treatment of attentional disorders, such as neglect e.g. 1,2. The method involves repeated pointing at specified targets with or without prism glasses using a specifically designed wooden box. The aim of this study was to ascertain...... whether the PAT method can be executed with similar effect using a computer with a touch screen.   62 healthy subjects were subjected to two experimental conditions: 1) pointing out at targets using the original box, 2) pointing out at targets on a computer attached touch screen. In both conditions......, the subjects performed a pre-test consisting of 30 targets without feedback, then an exposure-test of 90 targets with prism glasses and feedback, and finally a post-test of 60 targets, with no glasses and no feedback. Two experiments were carried out, 1) the feedback was provided by showing a cross...

  15. Calculating evidence-based renal replacement therapy - Introducing an excel-based calculator to improve prescribing and delivery in renal replacement therapy - A before and after study.

    Science.gov (United States)

    Cottle, Daniel; Mousdale, Stephen; Waqar-Uddin, Haroon; Tully, Redmond; Taylor, Benjamin

    2016-02-01

    Transferring the theoretical aspect of continuous renal replacement therapy to the bedside and delivering a given "dose" can be difficult. In research, the "dose" of renal replacement therapy is given as effluent flow rate in ml kg -1  h -1 . Unfortunately, most machines require other information when they are initiating therapy, including blood flow rate, pre-blood pump flow rate, dialysate flow rate, etc. This can lead to confusion, resulting in patients receiving inappropriate doses of renal replacement therapy. Our aim was to design an excel calculator which would personalise patient's treatment, deliver an effective, evidence-based dose of renal replacement therapy without large variations in practice and prolong filter life. Our calculator prescribes a haemodialfiltration dose of 25 ml kg -1  h -1 whilst limiting the filtration fraction to 15%. We compared the episodes of renal replacement therapy received by a historical group of patients, by retrieving their data stored on the haemofiltration machines, to a group where the calculator was used. In the second group, the data were gathered prospectively. The median delivered dose reduced from 41.0 ml kg -1  h -1 to 26.8 ml kg -1  h -1 with reduced variability that was significantly closer to the aim of 25 ml kg -1 .h -1 ( p  < 0.0001). The median treatment time increased from 8.5 h to 22.2 h ( p  = 0.00001). Our calculator significantly reduces variation in prescriptions of continuous veno-venous haemodiafiltration and provides an evidence-based dose. It is easy to use and provides personal care for patients whilst optimizing continuous veno-venous haemodiafiltration delivery and treatment times.

  16. Neutron irradiation therapy machine

    International Nuclear Information System (INIS)

    1980-01-01

    Conventional neutron irradiation therapy machines, based on the use of cyclotrons for producing neutron beams, use a superconducting magnet for the cyclotron's magnetic field. This necessitates complex liquid He equipment and presents problems in general hospital use. If conventional magnets are used, the weight of the magnet poles considerably complicates the design of the rotating gantry. Such a therapy machine, gantry and target facilities are described in detail. The use of protons and deuterons to produce the neutron beams is compared and contrasted. (U.K.)

  17. A Knowledge-Based Approach to Automatic Detection of Equipment Alarm Sounds in a Neonatal Intensive Care Unit Environment.

    Science.gov (United States)

    Raboshchuk, Ganna; Nadeu, Climent; Jancovic, Peter; Lilja, Alex Peiro; Kokuer, Munevver; Munoz Mahamud, Blanca; Riverola De Veciana, Ana

    2018-01-01

    A large number of alarm sounds triggered by biomedical equipment occur frequently in the noisy environment of a neonatal intensive care unit (NICU) and play a key role in providing healthcare. In this paper, our work on the development of an automatic system for detection of acoustic alarms in that difficult environment is presented. Such automatic detection system is needed for the investigation of how a preterm infant reacts to auditory stimuli of the NICU environment and for an improved real-time patient monitoring. The approach presented in this paper consists of using the available knowledge about each alarm class in the design of the detection system. The information about the frequency structure is used in the feature extraction stage, and the time structure knowledge is incorporated at the post-processing stage. Several alternative methods are compared for feature extraction, modeling, and post-processing. The detection performance is evaluated with real data recorded in the NICU of the hospital, and by using both frame-level and period-level metrics. The experimental results show that the inclusion of both spectral and temporal information allows to improve the baseline detection performance by more than 60%.

  18. How war veterans with post-traumatic stress disorder experience nature-based therapy in a forest therapy garden

    DEFF Research Database (Denmark)

    Poulsen, Dorthe Varning

    treatments. The objective of this Ph.D. project was to explore the impact of nature-based therapy (NBT) from the perspective of veterans suffering from PTSD. The thesis consists of two studies: A systematic literature review and a qualitative single-case study. The review aims to describe state......Since 1980 more than 30.000 Danish soldiers have been serving abroad. It is estimated that 5-8 % of them develop post-traumatic stress disorder (PTSD). Medicine and psychological treatment do not always lead to an improvement in the veteran’s condition and there is a need for complementary...

  19. Effectiveness of Mindfulness-based Therapy for Reducing Anxiety and Depression in Patients With Cancer

    Science.gov (United States)

    Zhang, Mei-Fen; Wen, Yong-Shan; Liu, Wei-Yan; Peng, Li-Fen; Wu, Xiao-Dan; Liu, Qian-Wen

    2015-01-01

    Abstract Anxiety and depression are common among patients with cancer, and are often treated with psychological interventions including mindfulness-based therapy. The aim of the study was to perform a meta-analysis of the effectiveness of mindfulness-based interventions for improving anxiety and depression in patients with cancer. Medline, the Cochrane Library, EMBASE, and Google Scholar were searched. The randomized controlled trials designed for patients diagnosed with cancer were included. Mindfulness-based interventions were provided. The outcomes assessed were the changes in anxiety and depression scores from before to after the intervention. The treatment response was determined by calculating the standardized mean difference (SMD) for individual studies and for pooled study results. Subgroup analyses by cancer type, type of therapy, and length of follow-up were performed. Seven studies, involving 469 participants who received mindfulness-based interventions and 419 participants in a control group, were included in the meta-analysis. Mindfulness-based stress reduction and art therapy were the most common interventions (5/7 studies). All studies reported anxiety and depression scores. The pooled SMD of the change in anxiety significantly favored mindfulness-based therapy over control treatment (−0.75, 95% confidence interval −1.28, −0.22, P = 0.005). Likewise, the pooled SMD of the change in depression also significantly favored mindfulness-based therapy over control (−0.90, 95% confidence interval −1.53, −0.26, P = 0.006). During the length of follow-ups less than 12 weeks, mindfulness-based therapy significantly improved anxiety for follow-up ≤12 weeks after the start of therapy, but not >12 weeks after the start of therapy. There was a lack of consistency between the studies in the type of mindfulness-based/control intervention implemented. Patients had different forms of cancer. Subgroup analyses included a relatively small number of

  20. Improving eye safety in citrus harvest crews through the acceptance of personal protective equipment, community-based participatory research, social marketing, and community health workers.

    Science.gov (United States)

    Tovar-Aguilar, J Antonio; Monaghan, Paul F; Bryant, Carol A; Esposito, Andrew; Wade, Mark; Ruiz, Omar; McDermott, Robert J

    2014-01-01

    For the last 10 years, the Partnership for Citrus Workers Health (PCWH) has been an evidence-based intervention program that promotes the adoption of protective eye safety equipment among Spanish-speaking farmworkers of Florida. At the root of this program is the systematic use of community-based preventive marketing (CBPM) and the training of community health workers (CHWs) among citrus harvester using popular education. CBPM is a model that combines the organizational system of community-based participatory research (CBPR) and the strategies of social marketing. This particular program relied on formative research data using a mixed-methods approach and a multilevel stakeholder analysis that allowed for rapid dissemination, effective increase of personal protective equipment (PPE) usage, and a subsequent impact on adoptive workers and companies. Focus groups, face-to-face interviews, surveys, participant observation, Greco-Latin square, and quasi-experimental tests were implemented. A 20-hour popular education training produced CHWs that translated results of the formative research to potential adopters and also provided first aid skills for eye injuries. Reduction of injuries is not limited to the use of safety glasses, but also to the adoption of timely intervention and regular eye hygiene. Limitations include adoption in only large companies, rapid decline of eye safety glasses without consistent intervention, technological limitations of glasses, and thorough cost-benefit analysis.

  1. Evidence-based diabetes nutrition therapy recommendations are effective: the key is individualization

    OpenAIRE

    Franz, Marion J; Boucher, Jackie L; Evert, Alison B

    2014-01-01

    Marion J Franz,1 Jackie L Boucher,2 Alison B Evert3 1Nutrition Concepts by Franz, Inc., Minneapolis, MN, 2Minneapolis Heart Institute Foundation, Minneapolis, MN, 3Diabetes Care Center, University of Washington Medical Center, Seattle, WA, USA Abstract: Current nutrition therapy recommendations for the prevention and treatment of diabetes are based on a systematic review of evidence and answer important nutrition care questions. First, is diabetes nutrition therapy effective? Clinical trials...

  2. Nutrition Therapy for Liver Diseases Based on the Status of Nutritional Intake

    OpenAIRE

    Yasutake, Kenichiro; Kohjima, Motoyuki; Nakashima, Manabu; Kotoh, Kazuhiro; Nakamuta, Makoto; Enjoji, Munechika

    2012-01-01

    The dietary intake of patients with nonalcoholic fatty liver disease (NAFLD) is generally characterized by high levels of carbohydrate, fat, and/or cholesterol, and these dietary patterns influence hepatic lipid metabolism in the patients. Therefore, careful investigation of dietary habits could lead to better nutrition therapy in NAFLD patients. The main treatment for chronic hepatitis C (CHC) is interferon-based antiviral therapy, which often causes a decrease in appetite and energy intake;...

  3. Strengthening School-Based Occupational Therapy through Peer Mentoring

    Science.gov (United States)

    Bucey, Janet C.; Provident, Ingrid M.

    2018-01-01

    This article evaluates a peer mentoring experience for school-based practitioners and its effect on collaborative consultation practices. Best practice and public school policy promote the use of collaborative consultation services but school-based practitioners report significant barriers in achieving effective collaborative consultation…

  4. Towards gene therapy based on femtosecond optical transfection

    Science.gov (United States)

    Antkowiak, M.; Torres-Mapa, M. L.; McGinty, J.; Chahine, M.; Bugeon, L.; Rose, A.; Finn, A.; Moleirinho, S.; Okuse, K.; Dallman, M.; French, P.; Harding, S. E.; Reynolds, P.; Gunn-Moore, F.; Dholakia, K.

    2012-06-01

    Gene therapy poses a great promise in treatment and prevention of a variety of diseases. However, crucial to studying and the development of this therapeutic approach is a reliable and efficient technique of gene and drug delivery into primary cell types. These cells, freshly derived from an organ or tissue, mimic more closely the in vivo state and present more physiologically relevant information compared to cultured cell lines. However, primary cells are known to be difficult to transfect and are typically transfected using viral methods, which are not only questionable in the context of an in vivo application but rely on time consuming vector construction and may also result in cell de-differentiation and loss of functionality. At the same time, well established non-viral methods do not guarantee satisfactory efficiency and viability. Recently, optical laser mediated poration of cell membrane has received interest as a viable gene and drug delivery technique. It has been shown to deliver a variety of biomolecules and genes into cultured mammalian cells; however, its applicability to primary cells remains to be proven. We demonstrate how optical transfection can be an enabling technique in research areas, such as neuropathic pain, neurodegenerative diseases, heart failure and immune or inflammatory-related diseases. Several primary cell types are used in this study, namely cardiomyocytes, dendritic cells, and neurons. We present our recent progress in optimizing this technique's efficiency and post-treatment cell viability for these types of cells and discuss future directions towards in vivo applications.

  5. Outcomes of couples with infidelity in a community-based sample of couple therapy.

    Science.gov (United States)

    Atkins, David C; Marín, Rebeca A; Lo, Tracy T Y; Klann, Notker; Hahlweg, Kurt

    2010-04-01

    Infidelity is an often cited problem for couples seeking therapy, but the research literature to date is very limited on couple therapy outcomes when infidelity is a problem. The current study is a secondary analysis of a community-based sample of couple therapy in Germany and Austria. Outcomes for 145 couples who reported infidelity as a problem in their relationship were compared with 385 couples who sought therapy for other reasons. Analyses based on hierarchical linear modeling revealed that infidelity couples were significantly more distressed and reported more depressive symptoms at the start of therapy but continued improving through the end of therapy and to 6 months posttherapy. At the follow-up assessment, infidelity couples were not statistically distinguishable from non-infidelity couples, replicating previous research. Sexual dissatisfaction did not depend on infidelity status. Although there was substantial missing data, sensitivity analyses suggested that the primary findings were not due to missing data. The current findings based on a large community sample replicated previous work from an efficacy trial and show generally optimistic results for couples in which there has been an affair. 2010 APA, all rights reserved

  6. Design Issues and Application of Cable-Based Parallel Manipulators for Rehabilitation Therapy

    Directory of Open Access Journals (Sweden)

    E. Ottaviano

    2008-01-01

    Full Text Available In this study, cable-based manipulators are proposed for application in rehabilitation therapies. Cable-based manipulators show good features that are very useful when the system has to interact with humans. In particular, they can be used to aid motion or as monitoring/training systems in rehabilitation therapies. Modelling and simulation of both active and passive cable-based parallel manipulators are presented for an application to help older people, patients or disabled people in the sit-to-stand transfer and as a monitoring/training system. Experimental results are presented by using built prototypes.

  7. Sound therapy and aural rehabilitation for tinnitus: a person centred therapy framework based on an ecological model of tinnitus.

    Science.gov (United States)

    Searchfield, Grant D; Linford, Tania; Durai, Mithila

    2018-03-23

    Tinnitus is a common oto-neurological complaint often accompanying hearing loss. In this perspective on rehabilitation we describe a framework for sound therapy and aural rehabilitation of tinnitus based on the ecological model of tinnitus. A thematic network analysis-based approach was used to relate aural rehabilitation methods to the ecological model of tinnitus and the client-oriented scale of improvement in tinnitus. Aural rehabilitation methods were mapped to concepts of: (1) Context, (2) presence of sound and (3) reaction to sound. A global theme was: adaptation to sound. The framework is the result of an iterative and cumulative research program exploring tinnitus as the outcome of the relationship between individual psychoacoustics and psychosocial factors including context of perception. The intent of this framework is to help guide audiologists managing tinnitus. The framework has been useful in our clinic as illustrated by a case study. The benefits of this approach relative to standard care needs to be independently ascertained. Implications for Rehabilitation Tinnitus is a common oto-neurological complaint that when severe can be very disabling. Tinnitus is very heterogeneous as a consequence of this no one treatment is suitable for everyone. The sound therapy and aural rehabilitation for tinnitus framework is designed to assist audiologists in clinical planning that addresses individual needs. The framework is the result of an iterative and cumulative research program exploring tinnitus as the outcome of the relationship between individual psychoacoustics and psychosocial factors including context of perception.

  8. Are community pharmacists equipped to ensure the safe use of oral anticancer therapy in the community setting? Results of a cross-country survey of community pharmacists in Canada.

    Science.gov (United States)

    Abbott, Rick; Edwards, Scott; Whelan, Maria; Edwards, Jonathan; Dranitsaris, George

    2014-02-01

    Oral anticancer agents offer significant benefits over parenteral anticancer therapy in terms of patient convenience and reduced intrusiveness. Oral anticancer agents give many cancer patients freedom from numerous hospital visits, allowing them to obtain their medications from their local community pharmacy. However, a major concern with increased use of oral anticancer agents is shift of responsibility in ensuring the proper use of anticancer agents from the hospital/clinical oncology team to the patient/caregiver and other healthcare providers such as the community pharmacists who may not be appropriately trained for this. This study assessed the readiness of community pharmacists across Canada to play this increased role with respect to oral anticancer agents. Using a structured electronic mailing strategy, a standardized survey was mailed to practicing pharmacists in five provinces where community pharmacists were dispensing the majority of oral anticancer agents. In addition to collecting basic demographic and their practice setting, the survey assessed the pharmacists' knowledge regarding cancer therapy and oral anticancer agents in particular, their education needs and access to resources on oral anticancer agents, the quality of prescriptions for oral anticancer agents received by them in terms of the required elements, their role in patient education, and steps to enhance patient and personal safety. There were 352 responses to the survey. Only 13.6% of respondents felt that they had received adequate oncology education at the undergraduate level and approximately 19% had attended a continuing education event related to oncology in the past 2 years. Only 24% of the pharmacists who responded were familiar with the common doses of oral anticancer agents and only 9% felt comfortable educating patients on these medications. A substantial portion of community pharmacists in Canada lack a solid understanding of oral anticancer agents and thus are poorly

  9. Track structure and dose: Alternative conceptual bases for nuclear therapy

    International Nuclear Information System (INIS)

    Katz, R.

    1987-01-01

    As one departs from the island of radiation quality encompassing photons and electrons of initial energy from about 100 keV to about 10 MeV toward increasingly higher LET particle irradiations, and from relatively uniform to inherently non-uniform radiation fields, dose and LET become less useful indices of radiation effect. Isodose profiles are not isoeffect profiles. RBEs vary with end point, with the state of oxygenation, with cell line, with tissue identity and with dose, and are multiple valued functions of LET. Dose, microdose and LET lack the descrimination needed to predict biological end points. RBE calculations made from cellular radiosensitivity parameters are consistent with RBEs measured both in vitro and in vivo. For such calculations, we must know the spectrum of particles and particle energies making up a high LET radiation field. To sharpen the calculations and make them directly relevant to therapy, we need to evaluate radiosensitivity parameters for human tissues. Both physical and biological data are needed for radiobiology and radiotherapy. For the question of hazard evaluation, we need to know the relation between transformations in vitro and cancer production in vivo. Using the same model as was used earlier for cellular inactivations, we have fitted tentative radiosensitivity parameters to recent data for cell transformations. The model is consistent with both gamma ray and fission neutron measurements. But a wider range of irradiations is needed to test these results. Delta rays play an important role in heavy ion radiobiology, but we do not now know either the cross-sections for delta ray production or the radial deposition of their energy with sufficient precision or generality. But it is this, the radial dose deposition, which is the physical basis for the calculation of action cross-sections. Studies for radiobiology and radiotherapy should also include the response of different physical detectors to a range of radiations, especially

  10. Irradiation position-control equipment for the HIMAC

    Energy Technology Data Exchange (ETDEWEB)

    Higashi, Seiichi; Kuma, Shoichiro [Mitsubishi Electric Corp., Tokyo (Japan); Nomura, Kazuaki; Endo, Masahiro; Minohara, Shin-ichi

    1995-02-01

    Use of heavy-ion beams to mount a pinpoint attack on unhealthy tissue requires that the target tissue be placed in the precise location specified by the therapy planning equipment. The article reports on the detailed specifications, positioning mechanism, position verification method and the interface with the therapy planning equipment. (author).

  11. What works best for whom? Cognitive Behavior Therapy and Mindfulness-Based Cognitive Therapy for depressive symptoms in patients with diabetes

    NARCIS (Netherlands)

    Tovote, K. Annika; Schroevers, Maya J.; Snippe, Evelien; Emmelkamp, Paul M.G.; Links, Thera P.; Sanderman, Robbert; Fleer, Joke

    2017-01-01

    Objective: Cognitive Behavior Therapy (CBT) and Mindfulness-Based Cognitive Therapy (MBCT) have shown to be effective interventions for treating depressive symptoms in patients with diabetes. However, little is known about which intervention works best for whom (i.e., moderators of efficacy). The

  12. Facilitation of research-based evidence within occupational therapy in stroke rehabilitation

    DEFF Research Database (Denmark)

    Kristensen, Hanne Kaae; Borg, T.; Hounsgaard, Lise

    2011-01-01

    Purpose: This study investigated the facilitation of evidence-based practice with the use of everyday life occupations and client-centred practice within occupational therapy in three settings of stroke rehabilitation. Method: The study was based on a phenomenological hermeneutical research...

  13. Repeated dose titration versus age-based method in electroconvulsive therapy: a pilot study

    NARCIS (Netherlands)

    Aten, J.J.; Oudega, M.L.; van Exel, E.; Stek, M.L.; van Waarde, J.A.

    2015-01-01

    In electroconvulsive therapy (ECT), a dose titration method (DTM) was suggested to be more individualized and therefore more accurate than formula-based dosing methods. A repeated DTM (every sixth session and dose adjustment accordingly) was compared to an age-based method (ABM) regarding treatment

  14. [Cost of therapy for neurodegenerative diseases. Applying an activity-based costing system].

    Science.gov (United States)

    Sánchez-Rebull, María-Victoria; Terceño Gómez, Antonio; Travé Bautista, Angeles

    2013-01-01

    To apply the activity based costing (ABC) model to calculate the cost of therapy for neurodegenerative disorders in order to improve hospital management and allocate resources more efficiently. We used the case study method in the Francolí long-term care day center. We applied all phases of an ABC system to quantify the cost of the activities developed in the center. We identified 60 activities; the information was collected in June 2009. The ABC system allowed us to calculate the average cost per patient with respect to the therapies received. The most costly and commonly applied technique was psycho-stimulation therapy. Focusing on this therapy and on others related to the admissions process could lead to significant cost savings. ABC costing is a viable method for costing activities and therapies in long-term day care centers because it can be adapted to their structure and standard practice. This type of costing allows the costs of each activity and therapy, or combination of therapies, to be determined and aids measures to improve management. Copyright © 2012 SESPAS. Published by Elsevier Espana. All rights reserved.

  15. The scenario-based generalization of radiation therapy margins

    International Nuclear Information System (INIS)

    Fredriksson, Albin; Bokrantz, Rasmus

    2016-01-01

    We give a scenario-based treatment plan optimization formulation that is equivalent to planning with geometric margins if the scenario doses are calculated using the static dose cloud approximation. If the scenario doses are instead calculated more accurately, then our formulation provides a novel robust planning method that overcomes many of the difficulties associated with previous scenario-based robust planning methods. In particular, our method protects only against uncertainties that can occur in practice, it gives a sharp dose fall-off outside high dose regions, and it avoids underdosage of the target in ‘easy’ scenarios. The method shares the benefits of the previous scenario-based robust planning methods over geometric margins for applications where the static dose cloud approximation is inaccurate, such as irradiation with few fields and irradiation with ion beams. These properties are demonstrated on a suite of phantom cases planned for treatment with scanned proton beams subject to systematic setup uncertainty. (paper)

  16. Introduction to Commercial Cooking Equipment. Learning Activity Pack and Instructor's Guide 4.1. Commercial Foods and Culinary Arts Competency-Based Series. Section 4: Equipment Handling, Operation and Maintenance.

    Science.gov (United States)

    Florida State Univ., Tallahassee. Center for Studies in Vocational Education.

    This document consists of a learning activity packet (LAP) for the student and an instructor's guide for the teacher. The LAP is intended to acquaint occupational home economics students with the workings of and equipment found in commercial kitchens. Illustrated information sheets and learning activities are provided on each of the following…

  17. Theory-based training strategies for modifying practitioner concerns about exposure therapy.

    Science.gov (United States)

    Farrell, Nicholas R; Deacon, Brett J; Dixon, Laura J; Lickel, James J

    2013-12-01

    Despite the well-established efficacy of exposure therapy in the treatment of pathological anxiety, many therapists believe this treatment carries an unacceptably high risk for harm, is intolerable for patients, and poses a number of ethical quandaries. These beliefs have been shown to account for two related problems: (a) underutilization of exposure therapy, and (b) overly cautious and suboptimal delivery the treatment, which likely attenuates treatment outcomes. At present, there is little guidance for those who train exposure therapists to address these concerns. This article reviews therapist negative beliefs about exposure therapy and discusses their modification based on findings from social and cognitive psychology pertinent to belief change, including dual-processing in reasoning, the need for cognition and affect, and attitude inoculation. A number of strategies are offered for augmenting training in exposure therapy in order to promote positive beliefs about the treatment. These strategies involve: (a) therapists engaging in simulated exposure therapy exercises and presenting arguments in defense of exposure's safety, tolerability, and ethicality, and (b) training therapists using emotion-based appeals (e.g., case examples) to supplement research findings. Directions for future research on practitioner concerns about exposure therapy are discussed. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. Operation monitor for plant equipment

    International Nuclear Information System (INIS)

    Kondo, Tetsufumi; Kanemoto, Shigeru.

    1991-01-01

    In a nuclear power plant, states of each of equipment in the plant are monitored accurately even under such a operation condition that the power is changed. That is, the fundamental idea is based on a model comparison method. A deviation between an output signal upon normal plant state obtained in a forecasting model device and that of the objective equipment in the plant are compared with a predetermined value. The result of the comparison is inputted to an alarm device to alarm the abnormality of the states of the equipment to an operator. The device of the present invention thus constituted can monitor the abnormality of the operation of equipment accurately even under such a condition that a power level fluctuates. As a result, it can remarkably contribute to mitigate operator's monitoring operation under the condition such as during load following operation. (I.S.)

  19. [Exercise Therapy in German Medical Rehabilitation - an Analysis based on Quantitative Routine Data].

    Science.gov (United States)

    Brüggemann, Silke; Sewöster, Daniela; Kranzmann, Angela

    2018-02-01

    This study describes the quantitative importance of exercise therapy in German medical rehabilitation based on 2014 routine data of the German Pension Insurance. It also shows changes in comparison with data from 2007. Data from 710012 rehabilitation discharge letters comprising 83677802 treatments from central indications in medical rehabilitation were analysed descriptively. Overall 35.4% of treatments could be classified as exercise therapy. Total and relative duration, percentage of individual treatment and kind of exercise treatment varied between indications in 2007 as well as in 2014. There were also differences between sexes, age groups and settings. During the period examined the high importance of exercise therapy in German medical rehabilitation has increased. The results point at a meaningful concept behind the composition of exercise therapy taking indications and disease related factors into account. © Georg Thieme Verlag KG Stuttgart · New York.

  20. A Monte Carlo-based treatment-planning tool for ion beam therapy

    CERN Document Server

    Böhlen, T T; Dosanjh, M; Ferrari, A; Haberer, T; Parodi, K; Patera, V; Mairan, A

    2013-01-01

    Ion beam therapy, as an emerging radiation therapy modality, requires continuous efforts to develop and improve tools for patient treatment planning (TP) and research applications. Dose and fluence computation algorithms using the Monte Carlo (MC) technique have served for decades as reference tools for accurate dose computations for radiotherapy. In this work, a novel MC-based treatment-planning (MCTP) tool for ion beam therapy using the pencil beam scanning technique is presented. It allows single-field and simultaneous multiple-fields optimization for realistic patient treatment conditions and for dosimetric quality assurance for irradiation conditions at state-of-the-art ion beam therapy facilities. It employs iterative procedures that allow for the optimization of absorbed dose and relative biological effectiveness (RBE)-weighted dose using radiobiological input tables generated by external RBE models. Using a re-implementation of the local effect model (LEM), theMCTP tool is able to perform TP studies u...

  1. Progressing a human embryonic stem-cell-based regenerative medicine therapy towards the clinic.

    Science.gov (United States)

    Whiting, Paul; Kerby, Julie; Coffey, Peter; da Cruz, Lyndon; McKernan, Ruth

    2015-10-19

    Since the first publication of the derivation of human embryonic stem cells in 1998, there has been hope and expectation that this technology will lead to a wave of regenerative medicine therapies with the potential to revolutionize our approach to managing certain diseases. Despite significant resources in this direction, the path to the clinic for an embryonic stem-cell-based regenerative medicine therapy has not proven straightforward, though in the past few years progress has been made. Here, with a focus upon retinal disease, we discuss the current status of the development of such therapies. We also highlight some of our own experiences of progressing a retinal pigment epithelium cell replacement therapy towards the clinic. © 2015 The Author(s).

  2. Endothelial progenitor cell-based neovascularization : implications for therapy

    NARCIS (Netherlands)

    Krenning, Guido; van Luyn, Marja J. A.; Harmsen, Martin C.

    Ischemic cardiovascular events are a major cause of death globally. Endothelial progenitor cell (EPC)-based approaches can result in improvement of vascular perfusion and might offer clinical benefit. However, although functional improvement is observed, the lack of long-term engraftment of EPCs

  3. Adapting Animal-Assisted Therapy Trials to Prison-Based Animal Programs.

    Science.gov (United States)

    Allison, Molly; Ramaswamy, Megha

    2016-09-01

    Prison-based animal programs have shown promise when it comes to increased sociability, responsibility, and levels of patience for inmates who participate in these programs. Yet there remains a dearth of scientific research that demonstrates the impact of prison-based animal programs on inmates' physical and mental health. Trials of animal-assisted therapy interventions, a form of human-animal interaction therapy most often used with populations affected by depression/anxiety, mental illness, and trauma, may provide models of how prison-based animal program research can have widespread implementation in jail and prison settings, whose populations have high rates of mental health problems. This paper reviews the components of prison-based animal programs most commonly practiced in prisons today, presents five animal-assisted therapy case studies, evaluates them based on their adaptability to prison-based animal programs, and discusses the institutional constraints that act as barriers for rigorous prison-based animal program research implementation. This paper can serve to inform the development of a research approach to animal-assisted therapy that nurses and other public health researchers can use in working with correctional populations. © 2016 Wiley Periodicals, Inc.

  4. Neuroprotective Mechanisms of Glucagon-like Peptide-1-based Therapies in Ischaemic Stroke

    DEFF Research Database (Denmark)

    Marlet, Ida R; Ölmestig, Joakim N E; Vilsbøll, Tina

    2018-01-01

    Review was to systematically evaluate the proposed mechanism of action for GLP-1-based therapies in ischaemic brain damage in animals. We performed a literature search using MEDLINE, EMBASE and The Cochrane Library. GLP-1-based therapies administered before, during or after experimental stroke in diabetic and non......Glucagon-like peptide-1 (GLP-1)-based therapies, GLP-1 receptor agonists (GLP-1RAs) and dipeptidyl peptidase-4 inhibitors (DPP-4Is) are widely used for the treatment of type 2 diabetes. Increasing evidence suggests that they may provide neuroprotection. The aim of this Mini......-diabetic animals were evaluated. We reviewed 27 studies comprised of 20 involving GLP-1RAs and seven involving DPP-4Is. Both GLP-1RAs and DPP-4Is affected the acute inflammatory response secondary to ischaemia by reducing inflammation, endothelial leakage and excitotoxicity. Both treatments also reduced oxidative...

  5. Proceedings of FED remote maintenance equipment workshop

    International Nuclear Information System (INIS)

    Sager, P.; Garin, J.; Hager, E.R.; Spampinato, P.T.; Tobias, D.; Young, N.

    1981-11-01

    A workshop was convened in two sessions in January and March 1981, on the remote maintenance equipment for the Fusion Engineering Device (FED). The objectives of the first session were to familiarize the participants with the status of the design of the FED and to develop a remote maintenance equipment list for the FED. The objective of the second session was to have the participants present design concepts for the equipment which had been identified in the first session. The equipment list was developed for general purpose and special purpose equipment. The general purpose equipment was categorized as manipulators and other, while the special purpose equipment was subdivided according to the reactor subsystem it serviced: electrical, magnetic, and nuclear. Both mobile and fixed base manipulators were identified. Handling machines were identified as the major requirement for special purpose equipment

  6. An agent-based approach equipped with game theory. Strategic collaboration among learning agents during a dynamic market change in the California electricity crisis

    Energy Technology Data Exchange (ETDEWEB)

    Sueyoshi, Toshiyuki [Department of Management, New Mexico Institute of Mining and Technology, Socorro, NM 87801 (United States); Department of Industrial and Information Management, National Cheng Kung University, Tainan (China)

    2010-09-15

    An agent-based approach is a numerical (computer-intensive) method to explore the complex characteristics and dynamics of microeconomics. Using the agent-based approach, this study investigates the learning speed of traders and their strategic collaboration in a dynamic market change of electricity. An example of such a market change can be found in the California electricity crisis (2000-2001). This study incorporates the concept of partial reinforcement learning into trading agents and finds that they have two learning components: learning from a dynamic market change and learning from collaboration with other traders. The learning speed of traders becomes slow when a large fluctuation occurs in the power exchange market. The learning speed depends upon the type of traders, their learning capabilities and the fluctuation of market fundamentals. The degree of collaboration among traders gradually reduces during the electricity crisis. The strategic collaboration among traders is examined by a large simulator equipped with multiple learning capabilities. (author)

  7. An agent-based approach equipped with game theory. Strategic collaboration among learning agents during a dynamic market change in the California electricity crisis

    International Nuclear Information System (INIS)

    Sueyoshi, Toshiyuki

    2010-01-01

    An agent-based approach is a numerical (computer-intensive) method to explore the complex characteristics and dynamics of microeconomics. Using the agent-based approach, this study investigates the learning speed of traders and their strategic collaboration in a dynamic market change of electricity. An example of such a market change can be found in the California electricity crisis (2000-2001). This study incorporates the concept of partial reinforcement learning into trading agents and finds that they have two learning components: learning from a dynamic market change and learning from collaboration with other traders. The learning speed of traders becomes slow when a large fluctuation occurs in the power exchange market. The learning speed depends upon the type of traders, their learning capabilities and the fluctuation of market fundamentals. The degree of collaboration among traders gradually reduces during the electricity crisis. The strategic collaboration among traders is examined by a large simulator equipped with multiple learning capabilities. (author)

  8. Shipboard and laboratory equipment

    Digital Repository Service at National Institute of Oceanography (India)

    Shyamprasad, M.; Ramaswamy, V.

    The polymetallic nodules occur at an average depth of 4500 m. Adequate equipment and techniques are required for the exploration at such depths. Shipboard and various laboratory equipments for the sampling of polymetallic nodules is described...

  9. Remote handling equipment

    International Nuclear Information System (INIS)

    Clement, G.

    1984-01-01

    After a definition of intervention, problems encountered for working in an adverse environment are briefly analyzed for development of various remote handling equipments. Some examples of existing equipments are given [fr

  10. Incretin-based therapy and risk of acute pancreatitis

    DEFF Research Database (Denmark)

    Thomsen, Reimar Wernich; Pedersen, Lars; Møller, Niels

    2015-01-01

    OBJECTIVE: To investigate whether the use of incretin-based drugs (GLP-1 receptor agonists and dipeptidyl peptidase 4 [DPP4] inhibitors) is associated with acute pancreatitis. RESEARCH DESIGN AND METHODS: The study was a nationwide population-based case-control study using medical databases...... in Denmark. Participants were 12,868 patients with a first-time hospitalization for acute pancreatitis between 2005 and 2012 and a population of 128,680 matched control subjects. The main outcome measure was the odds ratio (OR) for acute pancreatitis associated with different antihyperglycemic drugs. We...... adjusted for history of gallstones, alcoholism, obesity, and other pancreatitis-associated comorbidities and medications. RESULTS: A total of 89 pancreatitis patients (0.69%) and 684 control subjects (0.53%) were ever users of incretins. The crude OR for acute pancreatitis among incretin users was 1.36 (95...

  11. Exercise Equipment: Neutral Buoyancy

    Science.gov (United States)

    Shackelford, Linda; Valle, Paul

    2016-01-01

    Load Bearing Equipment for Neutral Buoyancy (LBE-NB) is an exercise frame that holds two exercising subjects in position as they apply counter forces to each other for lower extremity and spine loading resistance exercises. Resistance exercise prevents bone loss on ISS, but the ISS equipment is too massive for use in exploration craft. Integrating the human into the load directing, load generating, and motion control functions of the exercise equipment generates safe exercise loads with less equipment mass and volume.

  12. BP volume reduction equipment

    International Nuclear Information System (INIS)

    Kitamura, Yoshinori; Muroo, Yoji; Hamanaka, Isao

    2003-01-01

    A new type of burnable poison (BP) volume reduction system is currently being developed. Many BP rods, a subcomponent of spent fuel assemblies are discharged from nuclear power reactors. This new system reduces the overall volume of BP rods. The main system consists of BP rod cutting equipment, equipment for the recovery of BP cut pieces, and special transport equipment for the cut rods. The equipment is all operated by hydraulic press cylinders in water to reduce operator exposure to radioactivity. (author)

  13. Mindfulness and acceptance-based group therapy and traditional cognitive behavioral group therapy for social anxiety disorder: Mechanisms of change.

    Science.gov (United States)

    Kocovski, Nancy L; Fleming, Jan E; Hawley, Lance L; Ho, Moon-Ho Ringo; Antony, Martin M

    2015-07-01

    The present study investigated mechanisms of change for two group treatments for social anxiety disorder (SAD): cognitive behavioral group therapy (CBGT) and mindfulness and acceptance-based group therapy (MAGT). Participants were treatment completers (n = 37 for MAGT, n = 32 for CBGT) from a randomized clinical trial. Cognitive reappraisal was the hypothesized mechanism of change for CBGT. Mindfulness and acceptance were hypothesized mechanisms of change for MAGT. Latent difference score (LDS) analysis results demonstrate that cognitive reappraisal coupling (in which cognitive reappraisal is negatively associated with the subsequent rate of change in social anxiety) had a greater impact on social anxiety for CBGT than MAGT. The LDS bidirectional mindfulness model (mindfulness predicts subsequent change in social anxiety; social anxiety predicts subsequent change in mindfulness) was supported for both treatments. Results for acceptance were less clear. Cognitive reappraisal may be a more important mechanism of change for CBGT than MAGT, whereas mindfulness may be an important mechanism of change for both treatments. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. The design and implementation of the radiation therapy information management system (RTIMS) based on the workflow of radiation therapy

    International Nuclear Information System (INIS)

    Wu Qinhong; Li Gaofeng; Zhong Qiuzi; Hou Xiuyu; Li Ming; Xu Yonggang; He Jingxue

    2012-01-01

    Objective: To meet the special needs of the department of radiation oncology, a radiation therapy information management system (RTIMS) has been developed as a secondary database system to supplement the Varian Varis/Aria since 2007. Methods: The RTIMS server was used to run a database and web service of Apache + PHP + MySQL. The RTIMS sever's web service could be visited with Internet Explorer (IE) to input, search, count, and print information from about 30 workstations and 20 personal computers. As some workstations were installed with Windows and IE in English only, some functions had English version. Results: In past five years, as the RTIMS was implemented in the department, some further needs were met and more practical functions were developed. And now the RTIMS almost covered the whole workflow of radiation therapy (RT). By September 2011 , recorded patients data in the RTIMS is as follows: 3900 patients, 2600 outpatient RT records, 6800 progress notes, 1900 RT summaries, 6700 charge records, 83000 workload records, 3900 plan application forms, 1600 ICRT records. etc. Conclusions: The RTIMS based on the workflow of RT has been successfully developed and clinically implemented. And it was demonstrated to be user-friendly and was proven to significantly improve the efficiency of the department. Since it is an in-house developed system, more functions can be added or modified to further enhance its potentials in research and clinical practice. (authors)

  15. Feasibility Study Combining Art Therapy or Cognitive Remediation Therapy with Family-based Treatment for Adolescent Anorexia Nervosa.

    Science.gov (United States)

    Lock, James; Fitzpatrick, Kathleen Kara; Agras, William S; Weinbach, Noam; Jo, Booil

    2018-01-01

    Adolescents with anorexia nervosa who have obsessive-compulsive (OC) features respond poorly to family-based treatment (FBT). This study evaluated the feasibility of combining FBT with either cognitive remediation therapy (CRT) or art therapy (AT) to improve treatment response in this at-risk group. Thirty adolescents with anorexia nervosa and OC features were randomized to 15 sessions of FBT + CRT or AT. Recruitment rate was 1 per month, and treatment attrition was 16.6% with no differences between groups. Suitability, expectancy and therapeutic relationships were acceptable for both combinations. Correlations between changes in OC traits and changes in cognitive inefficiencies were found for both combinations. Moderate changes in cognitive inefficiencies were found in both groups but were larger in the FBT + AT combination. This study suggests that an RCT for poor responders to FBT because of OC traits combining FBT with either CRT or AT is feasible to conduct. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

  16. Clinical Study on the Visceral Differentiation-Based Acupuncture Therapy for Insomnia

    Institute of Scientific and Technical Information of China (English)

    LING Li; JIANG Xin-mei; XUE Jin-wei; WANG Miao; KE Rui

    2008-01-01

    objective;To investigate the clinical effects of acupuncture for insomnia on the basis of visceral differentiation.Methods;Seventy cases of insomnia were randomly divided into a treatment group and a control group,The former was treated by acupuncture based on visceral differentiation and the latter by the routine acupuncture therapy.Results;The clinical effcts were significantly better in the treatment group than that of the control group(P<0.05).Conclusion;The visceral difrerentiation-based acupuncture therapy may enhance the therapeutic effects for insomnia patients.

  17. Video-Based Learning vs Traditional Lecture for Instructing Emergency Medicine Residents in Disaster Medicine Principles of Mass Triage, Decontamination, and Personal Protective Equipment.

    Science.gov (United States)

    Curtis, Henry A; Trang, Karen; Chason, Kevin W; Biddinger, Paul D

    2018-02-01

    Introduction Great demands have been placed on disaster medicine educators. There is a need to develop innovative methods to educate Emergency Physicians in the ever-expanding body of disaster medicine knowledge. The authors sought to demonstrate that video-based learning (VBL) could be a promising alternative to traditional learning methods for teaching disaster medicine core competencies. Hypothesis/Problem The objective was to compare VBL to traditional lecture (TL) for instructing Emergency Medicine residents in the American College of Emergency Physicians (ACEP; Irving, Texas USA) disaster medicine core competencies of patient triage and decontamination. A randomized, controlled pilot study compared two methods of instruction for mass triage, decontamination, and personal protective equipment (PPE). Emergency Medicine resident learning was measured with a knowledge quiz, a Likert scale measuring comfort, and a practical exercise. An independent samples t-test compared the scoring of the VBL with the TL group. Twenty-six residents were randomized to VBL (n=13) or TL (n=13). Knowledge score improvement following video (14.9%) versus lecture (14.1%) did not differ significantly between the groups (P=.74). Comfort score improvement also did not differ (P=.64) between video (18.3%) and lecture groups (15.8%). In the practical skills assessment, the VBL group outperformed the TL group overall (70.4% vs 55.5%; Plearning vs traditional lecture for instructing emergency medicine residents in disaster medicine principles of mass triage, decontamination, and personal protective equipment. Prehosp Disaster Med. 2018;33(1):7-12.

  18. Fiber-array based optogenetic prosthetic system for stimulation therapy

    Science.gov (United States)

    Gu, Ling; Cote, Chris; Tejeda, Hector; Mohanty, Samarendra

    2012-02-01

    Recent advent of optogenetics has enabled activation of genetically-targeted neuronal cells using low intensity blue light with high temporal precision. Since blue light is attenuated rapidly due to scattering and absorption in neural tissue, optogenetic treatment of neurological disorders may require stimulation of specific cell types in multiple regions of the brain. Further, restoration of certain neural functions (vision, and auditory etc) requires accurate spatio-temporal stimulation patterns rather than just precise temporal stimulation. In order to activate multiple regions of the central nervous system in 3D, here, we report development of an optogenetic prosthetic comprising of array of fibers coupled to independently-controllable LEDs. This design avoids direct contact of LEDs with the brain tissue and thus does not require electrical and heat isolation, which can non-specifically stimulate and damage the local brain regions. The intensity, frequency, and duty cycle of light pulses from each fiber in the array was controlled independently using an inhouse developed LabView based program interfaced with a microcontroller driving the individual LEDs. While the temporal profile of the light pulses was controlled by varying the current driving the LED, the beam profile emanating from each fiber tip could be sculpted by microfabrication of the fiber tip. The fiber array was used to stimulate neurons, expressing channelrhodopsin-2, in different locations within the brain or retina. Control of neural activity in the mice cortex, using the fiber-array based prosthetic, is evaluated from recordings made with multi-electrode array (MEA). We also report construction of a μLED array based prosthetic for spatio-temporal stimulation of cortex.

  19. Development of a Hospital-based Massage Therapy Course at an Academic Medical Center.

    Science.gov (United States)

    Dion, Liza J; Cutshall, Susanne M; Rodgers, Nancy J; Hauschulz, Jennifer L; Dreyer, Nikol E; Thomley, Barbara S; Bauer, Brent

    2015-03-01

    Massage therapy is offered increasingly in US medical facilities. Although the United States has many massage schools, their education differs, along with licensure and standards. As massage therapy in hospitals expands and proves its value, massage therapists need increased training and skills in working with patients who have various complex medical concerns, to provide safe and effective treatment. These services for hospitalized patients can impact patient experience substantially and provide additional treatment options for pain and anxiety, among other symptoms. The present article summarizes the initial development and description of a hospital-based massage therapy course at a Midwest medical center. A hospital-based massage therapy course was developed on the basis of clinical experience and knowledge from massage therapists working in the complex medical environment. This massage therapy course had three components in its educational experience: online learning, classroom study, and a 25-hr shadowing experience. The in-classroom study portion included an entire day in the simulation center. The hospital-based massage therapy course addressed the educational needs of therapists transitioning to work with interdisciplinary medical teams and with patients who have complicated medical conditions. Feedback from students in the course indicated key learning opportunities and additional content that are needed to address the knowledge and skills necessary when providing massage therapy in a complex medical environment. The complexity of care in medical settings is increasing while the length of hospital stay is decreasing. For this reason, massage provided in the hospital requires more specialized training to work in these environments. This course provides an example initial step in how to address some of the educational needs of therapists who are transitioning to working in the complex medical environment.

  20. Computer-based Programs in Speech Therapy of Dyslalia and Dyslexia- Dysgraphia

    Directory of Open Access Journals (Sweden)

    Mirela Danubianu

    2010-04-01

    Full Text Available During the last years, the researchers and therapists in speech therapy have been more and more concerned with the elaboration and use of computer programs in speech disorders therapy. The main objective of this study was to evaluate the therapeutic effectiveness of computer-based programs for the Romanian language in speech therapy. Along the study, we will present the experimental research through assessing the effectiveness of computer programs in the speech therapy for speech disorders: dyslalia, dyslexia and dysgraphia. Methodologically, the use of the computer in the therapeutic phases was carried out with the help of some computer-based programs (Logomon, Dislex-Test etc. that we elaborated and we experimented with during several years of therapeutic activity. The sample used in our experiments was composed of 120 subjects; two groups of 60 children with speech disorders were selected for both speech disorders: 30 for the experimental ('computer-based' group and 30 for the control ('classical method' group. The study hypotheses verified whether the results, obtained by the subjects within the experimental group, improved significantly after using the computer-based program, compared to the subjects within the control group, who did not use this program but got a classical therapy. The hypotheses were confirmed for the speech disorders included in this research; the conclusions of the study confirm the advantages of using computer-based programs within speech therapy by correcting these disorders, as well as due to the positive influence these programs have on the development of children’s personality.

  1. A Neural Network-Based Gait Phase Classification Method Using Sensors Equipped on Lower Limb Exoskeleton Robots.

    Science.gov (United States)

    Jung, Jun-Young; Heo, Wonho; Yang, Hyundae; Park, Hyunsub

    2015-10-30

    An exact classification of different gait phases is essential to enable the control of exoskeleton robots and detect the intentions of users. We propose a gait phase classification method based on neural networks using sensor signals from lower limb exoskeleton robots. In such robots, foot sensors with force sensing registers are commonly used to classify gait phases. We describe classifiers that use the orientation of each lower limb segment and the angular velocities of the joints to output the current gait phase. Experiments to obtain the input signals and desired outputs for the learning and validation process are conducted, and two neural network methods (a multilayer perceptron and nonlinear autoregressive with external inputs (NARX)) are used to develop an optimal classifier. Offline and online evaluations using four criteria are used to compare the performance of the classifiers. The proposed NARX-based method exhibits sufficiently good performance to replace foot sensors as a means of classifying gait phases.

  2. [Evidence-based therapy of polycystic ovarian syndrome].

    Science.gov (United States)

    Gődény, Sándor; Csenteri, Orsolya Karola

    2015-11-08

    Polycystic ovary syndrome is recognized as the most common hormonal and metabolic disorder likely to affect women. The heterogeneous endocrinopathy is characterized by clinical and/or biochemical hyperandrogenism, oligo- or amenorrhoea, anovulatory infertility, and polycystic ovarian morphology. The syndrome is often associated with obesity, hyperinsulinemia and adversely affects endocrine, metabolic, and cardiovascular health. The symptoms and complaint of the patients vary with age. To maximise health gain of the syndrome, adequate, evidence based effective, efficient and safe treatment is necessary. This article summarises the highest available evidence provided by studies, meta-analysis and systematic reviews about the therapeutical possibilities for treating obesity, hyperandrogenism, menstrual abnormalities, infertility and psychological problems related to polycystic ovary syndrome.

  3. GPU-based fast pencil beam algorithm for proton therapy

    International Nuclear Information System (INIS)

    Fujimoto, Rintaro; Nagamine, Yoshihiko; Kurihara, Tsuneya

    2011-01-01

    Performance of a treatment planning system is an essential factor in making sophisticated plans. The dose calculation is a major time-consuming process in planning operations. The standard algorithm for proton dose calculations is the pencil beam algorithm which produces relatively accurate results, but is time consuming. In order to shorten the computational time, we have developed a GPU (graphics processing unit)-based pencil beam algorithm. We have implemented this algorithm and calculated dose distributions in the case of a water phantom. The results were compared to those obtained by a traditional method with respect to the computational time and discrepancy between the two methods. The new algorithm shows 5-20 times faster performance using the NVIDIA GeForce GTX 480 card in comparison with the Intel Core-i7 920 processor. The maximum discrepancy of the dose distribution is within 0.2%. Our results show that GPUs are effective for proton dose calculations.

  4. Onset of Celiac Disease after Treatment of Chronic Hepatitis C with Interferon Based Triple Therapy

    Directory of Open Access Journals (Sweden)

    Amandeep Singh

    2015-01-01

    Full Text Available Background. Patients treated with interferon (IFN based therapies may develop exacerbation of autoimmune disease. We herein present the case of a 53-year-old female patient who developed celiac disease (CD as a result of triple therapy (interferon, ribavirin, and boceprevir for chronic HCV. Case. 53-year-old Caucasian female with past medical history of IV drug abuse was referred for abnormal LFTs. Laboratory data showed HCV RNA of 4,515,392 IU/mL, HCV genotype 1a, with normal LFTs. She was treated with 4 weeks of pegylated interferon alfa-2a plus ribavirin, followed by triple therapy using boceprevir for a total of 28 weeks. Approximately 4 weeks after initiation of triple therapy patient developed loose nonbloody bowel movements and was also found to have anemia. Biopsies from first and second portions of the duodenum were consistent with CD. The patient was treated with a gluten-free diet. Her intestinal symptoms improved and the hemoglobin returned to normal. Conclusion. Chronic HCV patients being treated with interferon alfa can develop celiac disease during or after therapy. For patients with positive autoantibodies, all-oral-IFN-free regimens should be considered. Celiac disease should be considered in patients who develop CD-like symptoms while on and shortly after cessation of interferon alfa therapy.

  5. Problem based learning approaches to the technology education of physical therapy students.

    Science.gov (United States)

    Castro-Sánchez, Adelaida M; Aguilar-Ferrándiz, María Encarnación M E; Matarán-Peñarrocha, Guillermo A Ga; Iglesias-Alonso, Alberto A; Fernández-Fernández, Maria Jesus M J; Moreno-Lorenzo, Carmen C

    2012-01-01

    Problem-Based Learning (PBL) is a whole-curriculum concept. This study aimed to compare learning preferences and strategies between physical therapy students taught by PBL and those receiving conventional lectures on massage therapy, trauma physical therapy, and electrotherapy, hydrotherapy, and thermotherapy. This quasi-experimental study included 182 male and female students on physical therapy diploma courses at three universities in Andalusia (Spain). The Canfield Learning Skills Inventory (CLSI) was used to assess learning strategies and the Approaches to Study Skills Inventory for Students (ASSIST) to analyze study preferences. At the end of the academic year 2009/10, physical therapy students taught by PBL considered the most important learning strategies to be group work, study organization, relationship of ideas, and academic results. In comparison to conventionally taught counterparts, they considered that PBL reduced lack of purpose, memorizing without relating, the law of minimum effort, and fear of failure. Among these PBL students, the most highly rated study preferences were: organization of course tasks, cordial interaction with the teacher, learning by reading and images, and direct hands-on experience. For these physical therapy students, PBL facilitates learning strategies and study preferences in comparison to conventional teaching.

  6. Emerging treatment options for refractory angina pectoris: ranolazine, shock wave treatment, and cell-based therapies.

    Science.gov (United States)

    Gennari, Marco; Gambini, Elisa; Bassetti, Beatrice; Capogrossi, Maurizio; Pompilio, Giulio

    2014-01-01

    A challenge of modern cardiovascular medicine is to find new, effective treatments for patients with refractory angina pectoris, a clinical condition characterized by severe angina despite optimal medical therapy. These patients are not candidates for surgical or percutaneous revascularization. Herein we review the most up-to-date information regarding the modern approach to the patient with refractory angina pectoris, from conventional medical management to new medications and shock wave therapy, focusing on the use of endothelial precursor cells (EPCs) in the treatment of this condition. Clinical limitations of the efficiency of conventional approaches justify the search for new therapeutic options. Regenerative medicine is considered the next step in the evolution of organ replacement therapy. It is driven largely by the same health needs as transplantation and replacement therapies, but it aims further than traditional approaches, such as cell-based therapy. Increasing knowledge of the role of circulating cells derived from bone marrow (EPCs) on cardiovascular homeostasis in physiologic and pathologic conditions has prompted the clinical use of these cells to relieve ischemia. The current state of therapeutic angiogenesis still leaves many questions unanswered. It is of paramount importance that the treatment is delivered safely. Direct intramyocardial and intracoronary administration has demonstrated acceptable safety profiles in early trials, and may represent a major advance over surgical thoracotomy. The combined efforts of bench and clinical researchers will ultimately answer the question of whether cell therapy is a suitable strategy for treatment of patients with refractory angina.

  7. Electrical equipment qualification

    International Nuclear Information System (INIS)

    Farmer, W.S.

    1983-01-01

    Electrical equipment qualification research programs being carried out by CEA, JAERI, and Sandia Laboratories are discussed. Objectives of the program are: (1) assessment of accident simulation methods for electrical equipment qualification testing; lower coarse (2) evaluation of equipment aging and accelerated aging methods; (3) determine radiation dose spectrum to electrical equipment and assess simulation methods for qualification; (4) identify inadequacies in electrical equipment qualification procedures and standards and potential failure modes; and (5) provide data for verifying and improving standards, rules and regulatory guides

  8. The use of virtual reality-based therapy to augment poststroke upper limb recovery

    Science.gov (United States)

    Samuel, Geoffrey S; Choo, Min; Chan, Wai Yin; Kok, Stanley; Ng, Yee Sien

    2015-01-01

    Stroke remains one of the major causes of disability worldwide. This case report illustrates the complementary use of biomechanical and kinematic in-game markers, in addition to standard clinical outcomes, to comprehensively assess and track a patient’s disabilities. A 65-year-old patient was admitted for right-sided weakness and clinically diagnosed with acute ischaemic stroke. She participated in a short trial of standard stroke occupational therapy and physiotherapy with additional daily virtual reality (VR)-based therapy. Outcomes were tracked using kinematic data and conventional clinical assessments. Her Functional Independence Measure score improved from 87 to 113 and Fugl-Meyer motor score improved from 56 to 62, denoting clinically significant improvement. Corresponding kinematic analysis revealed improved hand path ratios and a decrease in velocity peaks. Further research is being undertaken to elucidate the optimal type, timing, setting and duration of VR-based therapy, as well as the use of neuropharmacological adjuncts. PMID:26243983

  9. Attachment-based family therapy for depressed and suicidal adolescents: theory, clinical model and empirical support.

    Science.gov (United States)

    Ewing, E Stephanie Krauthamer; Diamond, Guy; Levy, Suzanne

    2015-01-01

    Attachment-Based Family Therapy (ABFT) is a manualized family-based intervention designed for working with depressed adolescents, including those at risk for suicide, and their families. It is an empirically informed and supported treatment. ABFT has its theoretical underpinnings in attachment theory and clinical roots in structural family therapy and emotion focused therapies. ABFT relies on a transactional model that aims to transform the quality of adolescent-parent attachment, as a means of providing the adolescent with a more secure relationship that can support them during challenging times generally, and the crises related to suicidal thinking and behavior, specifically. This article reviews: (1) the theoretical foundations of ABFT (attachment theory, models of emotional development); (2) the ABFT clinical model, including training and supervision factors; and (3) empirical support.

  10. Accelerator Based Neutron Beams for Neutron Capture Therapy

    International Nuclear Information System (INIS)

    Yanch, Jacquelyn C.

    2003-01-01

    The DOE-funded accelerator BNCT program at the Massachusetts Institute of Technology has resulted in the only operating accelerator-based epithermal neutron beam facility capable of generating significant dose rates in the world. With five separate beamlines and two different epithermal neutron beam assemblies installed, we are currently capable of treating patients with rheumatoid arthritis in less than 15 minutes (knee joints) or 4 minutes (finger joints) or irradiating patients with shallow brain tumors to a healthy tissue dose of 12.6 Gy in 3.6 hours. The accelerator, designed by Newton scientific Incorporated, is located in dedicated laboratory space that MIT renovated specifically for this project. The Laboratory for Accelerator Beam Applications consists of an accelerator room, a control room, a shielded radiation vault, and additional laboratory space nearby. In addition to the design, construction and characterization of the tandem electrostatic accelerator, this program also resulted in other significant accomplishments. Assemblies for generating epithermal neutron beams were designed, constructed and experimentally evaluated using mixed-field dosimetry techniques. Strategies for target construction and target cooling were implemented and tested. We demonstrated that the method of submerged jet impingement using water as the coolant is capable of handling power densities of up to 6 x 10(sup 7) W/m(sup 2) with heat transfer coefficients of 10(sup 6)W/m(sup 2)-K. Experiments with the liquid metal gallium demonstrated its superiority compared with water with little effect on the neutronic properties of the epithermal beam. Monoenergetic proton beams generated using the accelerator were used to evaluate proton RBE as a function of LET and demonstrated a maximum RBE at approximately 30-40 keV/um, a finding consistent with results published by other researchers. We also developed an experimental approach to biological intercomparison of epithermal beams and

  11. Impact of region contouring variability on image-based focal therapy evaluation

    Science.gov (United States)

    Gibson, Eli; Donaldson, Ian A.; Shah, Taimur T.; Hu, Yipeng; Ahmed, Hashim U.; Barratt, Dean C.

    2016-03-01

    Motivation: Focal therapy is an emerging low-morbidity treatment option for low-intermediate risk prostate cancer; however, challenges remain in accurately delivering treatment to specified targets and determining treatment success. Registered multi-parametric magnetic resonance imaging (MPMRI) acquired before and after treatment can support focal therapy evaluation and optimization; however, contouring variability, when defining the prostate, the clinical target volume (CTV) and the ablation region in images, reduces the precision of quantitative image-based focal therapy evaluation metrics. To inform the interpretation and clarify the limitations of such metrics, we investigated inter-observer contouring variability and its impact on four metrics. Methods: Pre-therapy and 2-week-post-therapy standard-of-care MPMRI were acquired from 5 focal cryotherapy patients. Two clinicians independently contoured, on each slice, the prostate (pre- and post-treatment) and the dominant index lesion CTV (pre-treatment) in the T2-weighted MRI, and the ablated region (post-treatment) in the dynamic-contrast- enhanced MRI. For each combination of clinician contours, post-treatment images were registered to pre-treatment images using a 3D biomechanical-model-based registration of prostate surfaces, and four metrics were computed: the proportion of the target tissue region that was ablated and the target:ablated region volume ratio for each of two targets (the CTV and an expanded planning target volume). Variance components analysis was used to measure the contribution of each type of contour to the variance in the therapy evaluation metrics. Conclusions: 14-23% of evaluation metric variance was attributable to contouring variability (including 6-12% from ablation region contouring); reducing this variability could improve the precision of focal therapy evaluation metrics.

  12. Renewal of radiological equipment.

    Science.gov (United States)

    2014-10-01

    In this century, medical imaging is at the heart of medical practice. Besides providing fast and accurate diagnosis, advances in radiology equipment offer new and previously non-existing options for treatment guidance with quite low morbidity, resulting in the improvement of health outcomes and quality of life for the patients. Although rapid technological development created new medical imaging modalities and methods, the same progress speed resulted in accelerated technical and functional obsolescence of the same medical imaging equipment, consequently creating a need for renewal. Older equipment has a high risk of failures and breakdowns, which might cause delays in diagnosis and treatment of the patient, and safety problems both for the patient and the medical staff. The European Society of Radiology is promoting the use of up-to-date equipment, especially in the context of the EuroSafe Imaging Campaign, as the use of up-to-date equipment will improve quality and safety in medical imaging. Every healthcare institution or authority should have a plan for medical imaging equipment upgrade or renewal. This plan should look forward a minimum of 5 years, with annual updates. Teaching points • Radiological equipment has a definite life cycle span, resulting in unavoidable breakdown and decrease or loss of image quality which renders equipment useless after a certain time period.• Equipment older than 10 years is no longer state-of-the art equipment and replacement is essential. Operating costs of older equipment will be high when compared with new equipment, and sometimes maintenance will be impossible if no spare parts are available.• Older equipment has a high risk of failure and breakdown, causing delays in diagnosis and treatment of the patient and safety problems both for the patient and the medical staff.• Every healthcare institution or authority should have a plan for medical imaging equipment upgrade or replacement. This plan should look forward a

  13. Enhanced-safety underground nuclear power plants based on the use of proven ship-building equipment and technology

    International Nuclear Information System (INIS)

    Pashin, V.M.; Petrov, E.L.; Khazov, B.S.

    1995-01-01

    Investigations performed in the last few years by the State Science Center of the Russian Federation - Academician A. N. Krylov Central Scientific-Research Institute, together with specialized enterprises of the Ministry of Atomic Energy of the Russian Federation, Sudprom, and other agencies of Russia, have shown the promise of marine nuclear power plants for producing underground nuclear power plants with a higher degree of protection from external and internal actions of different intensity. The concept was developed on the basis of an analysis of the energy supply in different regions of Russia and the near-abroad using fossil fuels (lignite, oil, natural gas). The change in the international environment, which makes it possible to convert the military technology, frees the industrial potential and skilled workers in Russia for development of products for the national economy. Stricter international standards and rules for increased safety and protection of nuclear power plants made it necessary to develop a new generation of reactors for ground-based power plants, which under the modern economic conditions cannot be implemented within the time periods acceptable for economics for most of the countries surrounding Russia. In the development of a new generation of ground-based nuclear power plants, the intense improvement of the aviation and space technology must be taken into account. This is connected with the increase in the catastrophes and the threat they present to the safety of unprotected power plants. This article is an abstract of the entire report

  14. Celiac Disease and Drug-Based Therapies: Inquiry into Patients Demands.

    Science.gov (United States)

    Branchi, Federica; Tomba, Carolina; Ferretti, Francesca; Norsa, Lorenzo; Roncoroni, Leda; Bardella, Maria Teresa; Conte, Dario; Elli, Luca

    2016-01-01

    Medical research is looking for alternative drug-based options to the gluten-free diet (GFD) for celiac disease. We aimed at evaluating the need for alternative therapies perceived by celiac patients. During the 2013 meeting of the Lombardy section of the Italian Celiac Patients Association, adult subjects were invited to fill in a questionnaire investigating their clinical profile in relation to compliance to the diet, quality of life (QOL) as well as their opinion on alternative therapies. Three hundred and seventy two patients (76 m, mean age 41.7 ± 13.9 years) completed the questionnaire. Patients reported a significant improvement in health status (HS) and QOL after the diet was started (p < 0.001). The GFD was accepted by 88% patients, but the need for alternative therapies was reported by 65%. Subjects expressing the need for a drug-based therapy showed a lower increase in QOL (p = 0.003) and HS (p = 0.005) on GFD. The preferred option for an alternative therapy was the use of enzymes (145 subjects), followed by a vaccine (111 subjects). The GFD is favorably accepted by most celiac patients. Nevertheless, a proportion of patients pronounce themselves in favor of the development of alternative drugs. © 2016 S. Karger AG, Basel.

  15. [Family-Based Trauma-Focused Cognitive Behavioral Therapy with Three Siblings of a Refugee Family].

    Science.gov (United States)

    Bohnacker, Isabelle; Goldbeck, Lutz

    2017-10-01

    Family-Based Trauma-Focused Cognitive Behavioral Therapy with Three Siblings of a Refugee Family The possibility and relevance of a joint trauma-therapy with siblings has yet received little attention in research and clinical practice. The following case study presents a joint family-based trauma-focused therapy process with a refugee family. All three siblings suffered from post-traumatic stress disorder (PTSD) before treatment. The treatment followed the manual of Trauma Focused Cognitive Behavioral Therapy (TF-CBT; Cohen, Mannarino, Deblinger, 2009). Measures were the short version of the Child and Adolescent Trauma Screen (CATS 7-17), as well as the Teacher's Report Form (TRF). After 18 treatment sessions together with the mother, all three children did no longer meet PTSD criteria. Benefits of the joint therapy were for all three siblings to be sharing and imitating each other's coping strategies. Furthermore, the protective factor of social support after experiencing a traumatic event became evident. The apprehension of the therapist not being sufficiently neutral towards all three siblings was not observed.

  16. Extended-Kalman-filter-based regenerative and friction blended braking control for electric vehicle equipped with axle motor considering damping and elastic properties of electric powertrain

    Science.gov (United States)

    Lv, Chen; Zhang, Junzhi; Li, Yutong

    2014-11-01

    Because of the damping and elastic properties of an electrified powertrain, the regenerative brake of an electric vehicle (EV) is very different from a conventional friction brake with respect to the system dynamics. The flexibility of an electric drivetrain would have a negative effect on the blended brake control performance. In this study, models of the powertrain system of an electric car equipped with an axle motor are developed. Based on these models, the transfer characteristics of the motor torque in the driveline and its effect on blended braking control performance are analysed. To further enhance a vehicle's brake performance and energy efficiency, blended braking control algorithms with compensation for the powertrain flexibility are proposed using an extended Kalman filter. These algorithms are simulated under normal deceleration braking. The results show that the brake performance and blended braking control accuracy of the vehicle are significantly enhanced by the newly proposed algorithms.

  17. The first private-hospital based proton therapy center in Korea; Status of the proton therapy center at Samsung Medical Center

    International Nuclear Information System (INIS)

    Chung, Kwang Zoo; Han, Young Yih; Kim, Jin Sung

    2015-01-01

    The purpose of this report is to describe the proton therapy system at Samsung Medical Center (SMC-PTS) including the proton beam generator, irradiation system, patient positioning system, patient position verification system, respiratory gating system, and operating and safety control system, and review the current status of the SMC-PTS. The SMC-PTS has a cyclotron (230 MeV) and two treatment rooms: one treatment room is equipped with a multi-purpose nozzle and the other treatment room is equipped with a dedicated pencil beam scanning nozzle. The proton beam generator including the cyclotron and the energy selection system can lower the energy of protons down to 70 MeV from the maximum 230 MeV. The multi-purpose nozzle can deliver both wobbling proton beam and active scanning proton beam, and a multi-leaf collimator has been installed in the downstream of the nozzle. The dedicated scanning nozzle can deliver active scanning proton beam with a helium gas filled pipe minimizing unnecessary interactions with the air in the beam path. The equipment was provided by Sumitomo Heavy Industries Ltd., RayStation from RaySearch Laboratories AB is the selected treatment planning system, and data management will be handled by the MOSAIQ system from Elekta AB. The SMC-PTS located in Seoul, Korea, is scheduled to begin treating cancer patients in 2015

  18. The first private-hospital based proton therapy center in Korea; status of the Proton Therapy Center at Samsung Medical Center.

    Science.gov (United States)

    Chung, Kwangzoo; Han, Youngyih; Kim, Jinsung; Ahn, Sung Hwan; Ju, Sang Gyu; Jung, Sang Hoon; Chung, Yoonsun; Cho, Sungkoo; Jo, Kwanghyun; Shin, Eun Hyuk; Hong, Chae-Seon; Shin, Jung Suk; Park, Seyjoon; Kim, Dae-Hyun; Kim, Hye Young; Lee, Boram; Shibagaki, Gantaro; Nonaka, Hideki; Sasai, Kenzo; Koyabu, Yukio; Choi, Changhoon; Huh, Seung Jae; Ahn, Yong Chan; Pyo, Hong Ryull; Lim, Do Hoon; Park, Hee Chul; Park, Won; Oh, Dong Ryul; Noh, Jae Myung; Yu, Jeong Il; Song, Sanghyuk; Lee, Ji Eun; Lee, Bomi; Choi, Doo Ho

    2015-12-01

    The purpose of this report is to describe the proton therapy system at Samsung Medical Center (SMC-PTS) including the proton beam generator, irradiation system, patient positioning system, patient position verification system, respiratory gating system, and operating and safety control system, and review the current status of the SMC-PTS. The SMC-PTS has a cyclotron (230 MeV) and two treatment rooms: one treatment room is equipped with a multi-purpose nozzle and the other treatment room is equipped with a dedicated pencil beam scanning nozzle. The proton beam generator including the cyclotron and the energy selection system can lower the energy of protons down to 70 MeV from the maximum 230 MeV. The multi-purpose nozzle can deliver both wobbling proton beam and active scanning proton beam, and a multi-leaf collimator has been installed in the downstream of the nozzle. The dedicated scanning nozzle can deliver active scanning proton beam with a helium gas filled pipe minimizing unnecessary interactions with the air in the beam path. The equipment was provided by Sumitomo Heavy Industries Ltd., RayStation from RaySearch Laboratories AB is the selected treatment planning system, and data management will be handled by the MOSAIQ system from Elekta AB. The SMC-PTS located in Seoul, Korea, is scheduled to begin treating cancer patients in 2015.

  19. Two-Year Operational Evaluation Of A Consumer Electronics-Based Data Acquisition System For Equipment Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Van Hoy, Blake W. [ORNL; Phillips, Larry D. [ORNL; Wetherington Jr, G Randall [ORNL; Damiano, Brian [ORNL; Green, Craig [ORNL

    2017-04-01

    Oak Ridge National Laboratory (ORNL) has performed a two-year evaluation of the performance of an in-house developed consumer electronics-based data acquisition system (DAS). The main advantage of this approach compared to conventional instrumentation grade systems is cost; instrument grade data acquisition systems average costs range from $800 to $2,000 per channel compared to a range of $200 - $400 per channel for a consumer electronics-based system. The DAS is operated as a full-time in-situ vibration monitor. The resulting data stream is streamed over the ORNL network, at an aggregate rate of approximately 2 megabytes/s, to a Linux server. The server includes the capability to implement event-triggered data stores, as well as real-time files for the implementation of continuous display monitoring of the spectra. Detailed spectral analysis is performed post event. The DAS is installed on a large industrial chiller and cooling water pump associated with ORNL’s Titan supercomputer. These mechanical systems include rotating components that operate at fundamental frequencies within the range of 30 Hz to over 3 KHz. Evaluation of the DAS data over a two-year operating period leads to the conclusion that for many industrial processes this system could form the basis for a cost effective means of obtaining operating health data in real time from rotating machinery. The deployment has also shown that the DAS technology is reliable. Furthermore, because the cost of the DAS is low, the other significant advantage of this approach is that the DAS can be deployed in a dedicated manner and operated on a full-time basis.

  20. "Walkabout: Looking In, Looking Out": A Mindfulness-Based Art Therapy Program

    Science.gov (United States)

    Peterson, Caroline

    2015-01-01

    This brief report describes a mindfulness-based art therapy (MBAT) intervention, "Walkabout: Looking In, Looking Out," which was piloted in 2010 and has since been offered at the Abramson Cancer Center at Pennsylvania Hospital in Philadelphia. The author adapted the original MBAT intervention using a walkabout conceptual model, which was…

  1. Mindfulness-based therapy in adults with an autism spectrum disorder : A randomized controlled trial

    NARCIS (Netherlands)

    Spek, A.A.; van Ham, N.C.; Nyklicek, I.

    2013-01-01

    Research shows that depression and anxiety disorders are the most common psychiatric concern in autism spectrum disorders (ASD). Mindfulness-based therapy (MBT) has been found effective in reducing anxiety and depression symptoms, however research in autism is limited. Therefore, we examined the

  2. Melding Infant Mental Health and Multisystemic Therapy Approaches to Community-Based Treatment

    Science.gov (United States)

    Willoughby, Jay C.; Carubia, Beau A.; Murgolo, Marisa A.; Carter, Debbie R.; Frankel, Karen A.

    2013-01-01

    A recent partnership between the Irving Harris Program in Child Development and Infant Mental Health and the Community Based Psychiatry Program at University of Colorado Hospital joined two different approaches to child mental health treatment: infant mental health and multisystemic therapy (MST). This article illustrates the compatibility of…

  3. Web-Based Cognitive Behavioral Therapy for Female Patients With Eating Disorders : Randomized Controlled Trial

    NARCIS (Netherlands)

    ter Huurne, E.D.; de Haan, H.A.; Postel, Marloes Gerda; van der Palen, Jacobus Adrianus Maria; VanDerNagel, Joanneke E.L.; de Jong, Cor A.J.

    2015-01-01

    Background: Many patients with eating disorders do not receive help for their symptoms, even though these disorders have severe morbidity. The Internet may offer alternative low-threshold treatment interventions. Objective: This study evaluated the effects of a Web-based cognitive behavioral therapy

  4. Predictors of outcome of group and internet-based cognitive behaviour therapy.

    NARCIS (Netherlands)

    Spek, V.; Nyklicek, I.; Cuijpers, P.; Pop, V.

    2008-01-01

    Background: Little is known about which participant characteristics determine the effectiveness of various types of cognitive behavior therapy for sub-threshold depression. The aim of this study was to investigate which characteristics predict treatment outcome of group and internet-based

  5. Integrating EMDR into an evolutionary-based therapy for depression: a case study

    OpenAIRE

    Krupnik, Valery

    2015-01-01

    Key Clinical Message We present an intervention in a case of major depression, where eye movement desensitization and reprocessing (EMDR) therapy was integrated into an evolutionary-based psychotherapy for depression. At the end of the treatment and at follow up assessment we observed a more accepting disposition and decreased depressive but not anxiety symptoms.

  6. Integrating EMDR into an evolutionary-based therapy for depression: a case study

    Science.gov (United States)

    Krupnik, Valery

    2015-01-01

    Key Clinical Message We present an intervention in a case of major depression, where eye movement desensitization and reprocessing (EMDR) therapy was integrated into an evolutionary-based psychotherapy for depression. At the end of the treatment and at follow up assessment we observed a more accepting disposition and decreased depressive but not anxiety symptoms. PMID:25984310

  7. The Beck Initiative: Training School-Based Mental Health Staff in Cognitive Therapy

    Science.gov (United States)

    Creed, Torrey A.; Jager-Hyman, Shari; Pontoski, Kristin; Feinberg, Betsy; Rosenberg, Zachary; Evans, Arthur; Hurford, Matthew O.; Beck, Aaron T.

    2013-01-01

    A growing literature supports cognitive therapy (CT) as an efficacious treatment for youth struggling with emotional or behavioral problems. Recently, work in this area has extended the dissemination of CT to school-based settings. The current study has two aims: 1) to examine the development of therapists' knowledge and skills in CT, an…

  8. Mindfulness-based cognitive therapy for people with diabetes and emotional problems

    DEFF Research Database (Denmark)

    VAN Son, Jenny; Nyklíček, Ivan; Pop, Victor J M

    2014-01-01

    OBJECTIVE: The DiaMind trial showed beneficial immediate effects of mindfulness-based cognitive therapy (MBCT) on emotional distress, but not on diabetes distress and HbA1c. The aim of the present report was to examine if the effects would be sustained after six month follow-up. METHODS: In the Dia...

  9. Does Mindfulness-Based Cognitive Therapy benefit all people with diabetes and comorbid emotional complaints equally?

    DEFF Research Database (Denmark)

    Nyklíček, Ivan; VAN Son, Jenny; Pop, Victor J M

    2016-01-01

    , and baseline levels of mindfulness skills) moderate the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT)? METHODS: Outpatients with diabetes (type 1 or type 2; N=139) and an elevated level of emotional distress participated in the Diabetes and Mindfulness (DiaMind) trial. They were randomized...

  10. Internet-based cognitive behavioral therapy for adolescents with anxiety disorders: A feasibility study

    DEFF Research Database (Denmark)

    Stjerneklar, Silke; Hougaard, Esben; Nielsen, Amalie D.

    2018-01-01

    Background: Cognitive behavioral therapy (CBT) is a well-documented effective method for the treatment of anxiety disorders in children and adolescents. While internet based CBT (ICBT) programs for adults have been widely investigated, research on ICBT programs for anxiety disorders in youth...

  11. Controversial issue: is it safe to employ mesenchymal stem cells in cell-based therapies?

    DEFF Research Database (Denmark)

    Lepperdinger, Günter; Brunauer, Regina; Jamnig, Angelika

    2008-01-01

    The prospective clinical use of multipotent mesenchymal stromal stem cells (MSC) holds enormous promise for the treatment of a large number of degenerative and age-related diseases. However, the challenges and risks for cell-based therapies are multifaceted. The risks for patients receiving stem ...

  12. Feasibility of a Prototype Web-Based Acceptance and Commitment Therapy Prevention Program for College Students

    Science.gov (United States)

    Levin, Michael E.; Pistorello, Jacqueline; Seeley, John R.; Hayes, Steven C.

    2014-01-01

    Objective: This study examined the feasibility of a prototype Web-based acceptance and commitment therapy (ACT) program for preventing mental health problems among college students. Participants: Undergraduate first-year students ("N" = 76) participated between May and November 2011. Methods: Participants were randomized to ACT or a…

  13. Effectiveness of Morita Therapy-Based Consultation for a School-Refusing Adolescent with Psychogenic Fever

    Science.gov (United States)

    Maeda, Naoki

    2017-01-01

    Morita therapy, developed by Shoma Morita (1874-1938) in Japan, is a type of psychotherapy that has been applied to deal with neurotic symptoms. This therapeutic approach is based on the conviction that neurotic symptoms are universal issues that eventually subside if the symptoms are accepted and everyday activities are carried out. By examining…

  14. Teaching evidence-based speech and language therapy: Influences from formal and informal curriculum

    NARCIS (Netherlands)

    Spek, B.

    2015-01-01

    This dissertation focuses on influences from formal and informal curriculum on the effectiveness of teaching evidence-based speech and language therapy. A study showed that while EBP knowledge and skills increase during the years of study, motivational beliefs such as EBP task value and

  15. Evaluating a Web-Based Cognitive-Behavioral Therapy for Maladaptive Perfectionism in University Students

    Science.gov (United States)

    Radhu, Natasha; Daskalakis, Zafiris J.; Arpin-Cribbie, Chantal A.; Irvine, Jane; Ritvo, Paul

    2012-01-01

    Objective: This study assessed a Web-based cognitive-behavioral therapy (CBT) for maladaptive perfectionism, investigating perfectionism, anxiety, depression, negative automatic thoughts, and perceived stress. Participants: Participants were undergraduate students defined as maladaptive perfectionists through a screening questionnaire at an urban…

  16. Stem and Progenitor Cell-Based Therapy of the Central Nervous System

    DEFF Research Database (Denmark)

    Goldman, Steven A.

    2016-01-01

    A variety of neurological disorders are attractive targets for stem and progenitor cell-based therapy. Yet many conditions are not, whether by virtue of an inhospitable disease environment, poorly understood pathophysiology, or poor alignment of donor cell capabilities with patient needs. Moreove...

  17. First empirical evaluation of outcomes for mentalization-based group therapy for adolescents with BPD

    DEFF Research Database (Denmark)

    Bo, Sune; Sharp, Carla; Beck, Emma

    2017-01-01

    Adolescent borderline personality disorder (BPD) is a devastating disorder, and it is essential to identify and treat the disorder in its early course. A total of 34 female Danish adolescents between 15 and 18 years old participated in 1 year of structured mentalization-based group therapy. Twent...... with borderline traits. (PsycINFO Database RecordCopyright (c) 2017 APA, all rights reserved)....

  18. Visual outcome after fractionated stereotactic radiation therapy of benign anterior skull base tumors

    DEFF Research Database (Denmark)

    Astradsson, Arnar; Wiencke, Anne Katrine; Munck af Rosenschold, Per

    2014-01-01

    To determine visual outcome including the occurrence of radiation induced optic neuropathy (RION) as well as tumor control after fractionated stereotactic radiation therapy (FSRT) of benign anterior skull base meningiomas or pituitary adenomas. Thirty-nine patients treated with FSRT for anterior...

  19. The clinical relevance of cell-based therapy for the treatment of stress urinary incontinence

    DEFF Research Database (Denmark)

    Gräs, Søren; Lose, Gunnar

    2011-01-01

    Stress urinary incontinence is a common disorder affecting the quality of life for millions of women worldwide. Effective surgical procedures involving synthetic permanent meshes exist, but significant short- and long-term complications occur. Cell-based therapy using autologous stem cells...

  20. GLP-1-based therapies have no microvascular effects in type 2 diabetes mellitus

    NARCIS (Netherlands)

    Smits, Mark M.; Tonneijck, Lennart; Muskiet, Marcel H.A.; Hoekstra, Trynke; Kramer, Mark H.H.; Diamant, Michaela; Serné, Erik H.; Van Raalte, Daniël H.

    2016-01-01

    Objective - To assess the effects of glucagon-like peptide (GLP)-1-based therapies (ie, GLP-1 receptor agonists and dipeptidyl peptidase-4 inhibitors) on microvascular function in patients with type 2 diabetes mellitus. Approach and Results - We studied 57 patients with type 2 diabetes mellitus

  1. Comparative Outcome Analysis of Penicillin-Based Versus Fluoroquinolone-Based Antibiotic Therapy for Community-Acquired Pneumonia

    Science.gov (United States)

    Wang, Chi-Chuan; Lin, Chia-Hui; Lin, Kuan-Yin; Chuang, Yu-Chung; Sheng, Wang-Huei

    2016-01-01

    Abstract Community-acquired pneumonia (CAP) is a common but potentially life-threatening condition, but limited information exists on the effectiveness of fluoroquinolones compared to β-lactams in outpatient settings. We aimed to compare the effectiveness and outcomes of penicillins versus respiratory fluoroquinolones for CAP at outpatient clinics. This was a claim-based retrospective cohort study. Patients aged 20 years or older with at least 1 new pneumonia treatment episode were included, and the index penicillin or respiratory fluoroquinolone therapies for a pneumonia episode were at least 5 days in duration. The 2 groups were matched by propensity scores. Cox proportional hazard models were used to compare the rates of hospitalizations/emergence service visits and 30-day mortality. A logistic model was used to compare the likelihood of treatment failure between the 2 groups. After propensity score matching, 2622 matched pairs were included in the final model. The likelihood of treatment failure of fluoroquinolone-based therapy was lower than that of penicillin-based therapy (adjusted odds ratio [AOR], 0.88; 95% confidence interval [95%CI], 0.77–0.99), but no differences were found in hospitalization/emergence service (ES) visits (adjusted hazard ratio [HR], 1.27; 95% CI, 0.92–1.74) and 30-day mortality (adjusted HR, 0.69; 95% CI, 0.30–1.62) between the 2 groups. The likelihood of treatment failure of fluoroquinolone-based therapy was lower than that of penicillin-based therapy for CAP on an outpatient clinic basis. However, this effect may be marginal. Further investigation into the comparative effectiveness of these 2 treatment options is warranted. PMID:26871827

  2. Mindfulness-based cognitive therapy for recurrent major depression: A 'best buy' for health care?

    Science.gov (United States)

    Shawyer, Frances; Enticott, Joanne C; Özmen, Mehmet; Inder, Brett; Meadows, Graham N

    2016-10-01

    While mindfulness-based cognitive therapy is effective in reducing depressive relapse/recurrence, relatively little is known about its health economic properties. We describe the health economic properties of mindfulness-based cognitive therapy in relation to its impact on depressive relapse/recurrence over 2 years of follow-up. Non-depressed adults with a history of three or more major depressive episodes were randomised to mindfulness-based cognitive therapy + depressive relapse active monitoring (n = 101) or control (depressive relapse active monitoring alone) (n = 102) and followed up for 2 years. Structured self-report instruments for service use and absenteeism provided cost data items for health economic analyses. Treatment utility, expressed as disability-adjusted life years, was calculated by adjusting the number of days an individual was depressed by the relevant International Classification of Diseases 12-month severity of depression disability weight from the Global Burden of Disease 2010. Intention-to-treat analysis assessed the incremental cost-utility ratios of the interventions across mental health care, all of health-care and whole-of-society perspectives. Per protocol and site of usual care subgroup analyses were also conducted. Probabilistic uncertainty analysis was completed using cost-utility acceptability curves. Mindfulness-based cognitive therapy participants had significantly less major depressive episode days compared to controls, as supported by the differential distributions of major depressive episode days (modelled as Poisson, p cognitive therapy group compared to controls, e.g., 31 and 55 days, respectively. From a whole-of-society perspective, analyses of patients receiving usual care from all sectors of the health-care system demonstrated dominance (reduced costs, demonstrable health gains). From a mental health-care perspective, the incremental gain per disability-adjusted life year for mindfulness-based

  3. Non-genetic engineering of cells for drug delivery and cell-based therapy.

    Science.gov (United States)

    Wang, Qun; Cheng, Hao; Peng, Haisheng; Zhou, Hao; Li, Peter Y; Langer, Robert

    2015-08-30

    Cell-based therapy is a promising modality to address many unmet medical needs. In addition to genetic engineering, material-based, biochemical, and physical science-based approaches have emerged as novel approaches to modify cells. Non-genetic engineering of cells has been applied in delivering therapeutics to tissues, homing of cells to the bone marrow or inflammatory tissues, cancer imaging, immunotherapy, and remotely controlling cellular functions. This new strategy has unique advantages in disease therapy and is complementary to existing gene-based cell engineering approaches. A better understanding of cellular systems and different engineering methods will allow us to better exploit engineered cells in biomedicine. Here, we review non-genetic cell engineering techniques and applications of engineered cells, discuss the pros and cons of different methods, and provide our perspectives on future research directions. Copyright © 2014 Elsevier B.V. All rights reserved.

  4. End-User Recommendations on LOGOMON - a Computer Based Speech Therapy System for Romanian Language

    Directory of Open Access Journals (Sweden)

    SCHIPOR, O. A.

    2010-11-01

    Full Text Available In this paper we highlight the relations between LOGOMON - a Computer Based Speech Therapy System and dyslalia's training steps. Dyslalia is a speech disorder that affects pronunciation of one or many sounds. This presentation of the system is completed by a research regarding end-user (i.e. teachers and parents attitude about the speech assisted therapy in general and about LOGOMON System in particular. The results of this research allow the improvement of our CBST system because the obtained information can be a source of adaptability to different expectations of the beneficiaries.

  5. E-Learning-Based Occupational Therapy Education Leads to Committed Students

    DEFF Research Database (Denmark)

    Bensen, Maria; Kolbæk, Ditte

    2017-01-01

    students engagement in e-learning based professional bachelor educations such as Occupational Therapy (OT). The research questions in this study are: On the basis of the OT-students experiences, how can learning activities be supported in a synchronous, virtual learning environment as Adobe Connect? How do...... the results of this study to form the design of e-learning/blended learning in their programme in order to enhance students’ engagement. It also includes a modified, phenomenological way of using memory-work. This study is unique in its use of Adobe Connect in a practical education as Occupational Therapy...

  6. The potential of methylxanthine-based therapies in pediatric respiratory tract diseases.

    Science.gov (United States)

    Oñatibia-Astibia, Ainhoa; Martínez-Pinilla, Eva; Franco, Rafael

    2016-03-01

    Caffeine, theophylline and theobromine are the most known methylxanthines as they are present in coffee, tea and/or chocolate. In the last decades, a huge experimental effort has been devoted to get insight into the variety of actions that these compounds exert in humans. From such knowledge it is known that methylxanthines have a great potential in prevention, therapy and/or management of a variety of diseases. The benefits of methylxanthine-based therapies in the apnea of prematurity and their translational potential in pediatric affections of the respiratory tract are here presented. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Equipping community pharmacy workers as agents for health behaviour change: developing and testing a theory-based smoking cessation intervention.

    Science.gov (United States)

    Steed, Liz; Sohanpal, Ratna; James, Wai-Yee; Rivas, Carol; Jumbe, Sandra; Chater, Angel; Todd, Adam; Edwards, Elizabeth; Macneil, Virginia; Macfarlane, Fraser; Greenhalgh, Trisha; Griffiths, Chris; Eldridge, Sandra; Taylor, Stephanie; Walton, Robert

    2017-08-11

    To develop a complex intervention for community pharmacy staff to promote uptake of smoking cessation services and to increase quit rates. Following the Medical Research Council framework, we used a mixed-methods approach to develop, pilot and then refine the intervention. Phase I : We used information from qualitative studies in pharmacies, systematic literature reviews and the Capability, Opportunity, Motivation-Behaviour framework to inform design of the initial version of the intervention. Phase II : We then tested the acceptability of this intervention with smoking cessation advisers and assessed fidelity using actors who visited pharmacies posing as smokers, in a pilot study. Phase III : We reviewed the content and associated theory underpinning our intervention, taking account of the results of the earlier studies and a realist analysis of published literature. We then confirmed a logic model describing the intended operation of the intervention and used this model to refine the intervention and associated materials. Eight community pharmacies in three inner east London boroughs. 12 Stop Smoking Advisers. Two, 150 min, skills-based training sessions focused on communication and behaviour change skills with between session practice. The pilot study confirmed acceptability of the intervention and showed preliminary evidence of benefit; however, organisational barriers tended to limit effective operation. The pilot data and realist review pointed to additional use of Diffusion of Innovations Theory to seat the intervention in the wider organisational context. We have developed and refined an intervention to promote smoking cessation services in community pharmacies, which we now plan to evaluate in a randomised controlled trial. UKCRN ID 18446, Pilot. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  8. Usuários de drogas injetáveis e terapia anti-retroviral: percepções das equipes de farmácia Injecting drug users and antiretroviral therapy: perceptions of pharmacy teams

    Directory of Open Access Journals (Sweden)

    Chizuru Minami Yokaichiya

    2007-12-01

    adherence to antiretroviral therapy by injecting drug users living with HIV/AIDS. METHODS: Qualitative study through focus groups and thematic discourse analysis of pharmacists, technicians and assistants with more than six months of experience with medication supply, in 15 assisting units for STD/AIDS in the city of São Paulo, in 2002. RESULTS: Three groups were formed, totaling 29 participants, originating from 12 out of the 15 existing services, and including 12 university level professionals and 17 high-school level professionals. The groups concluded that the pharmacy has an important role in the antiretroviral drug supply, which is reflected in the treatment adherence, because trust-based relationships can be built up through their procedures. In spite of this, they pointed out that such building-up does not take place through excessively bureaucratic activities. This has negative repercussions for all patients, especially for injecting drug users, considered "difficult people". Such concept sums up their behavior: they are supposed to be confused and incapable to adhere to treatment, and have limited understanding. Staff members, however, affirm they treat these patients equally. They do not realize that, by this acting, the specific needs of injecting drug users may become invisible in the service. There is also the possibility that stigmatizing stereotypes may be created, resulting in yet another barrier to the work on adherence. CONCLUSIONS: Although the pharmacy is recommended as a potentially favorable place to listen to and form bonds with users, the results show objective and subjective obstacles to render it suitable for the work on adherence.

  9. Laser apparatus for surgery and force therapy based on high-power semiconductor and fibre lasers

    International Nuclear Information System (INIS)

    Minaev, V P

    2005-01-01

    High-power semiconductor lasers and diode-pumped lasers are considered whose development qualitatively improved the characteristics of laser apparatus for surgery and force therapy, extended the scope of their applications in clinical practice, and enhanced the efficiency of medical treatment based on the use of these lasers. The characteristics of domestic apparatus are presented and their properties related to the laser emission wavelength used in them are discussed. Examples of modern medical technologies based on these lasers are considered. (invited paper)

  10. Effectiveness of Mindfulness-based Therapy for Reducing Anxiety and Depression in Patients With Cancer

    OpenAIRE

    Zhang, Mei-Fen; Wen, Yong-Shan; Liu, Wei-Yan; Peng, Li-Fen; Wu, Xiao-Dan; Liu, Qian-Wen

    2015-01-01

    Abstract Anxiety and depression are common among patients with cancer, and are often treated with psychological interventions including mindfulness-based therapy. The aim of the study was to perform a meta-analysis of the effectiveness of mindfulness-based interventions for improving anxiety and depression in patients with cancer. Medline, the Cochrane Library, EMBASE, and Google Scholar were searched. The randomized controlled trials designed for patients diagnosed with cancer were included....

  11. Platinum-Based Therapy in Adenosquamous Pancreatic Cancer: Experience at Two Institutions

    OpenAIRE

    Andre Luiz De Souza; Muhammad Wasif Saif

    2014-01-01

    Adenosquamous carcinoma of the pancreas is a rare type of pancreatic cancer. Although its molecular biology profile hasbeen shown to be similar to pancreatic ductal adenocarcinoma tumors, it has different prognostic features. There is noconsensus or guidelines to treat this tumor differently from pancreatic adenocarcinoma, but therapies based on gemcitabineand platinum chemotherapeutics such as cisplatin and oxaliplatin have been used based on results of a few case reports. Wediscuss the Abst...

  12. Evaluation of polyelectrolyte complex-based scaffolds for mesenchymal stem cell therapy in cardiac ischemia treatment

    OpenAIRE

    Ceccaldi, Caroline; Bushkalova, Raya; Alfarano, Chiara; Lairez, Olivier; Calise, Denis; Bourin, Philippe; Frugier, Céline; Rouzaud-Laborde, Charlotte; Cussac, Daniel; Parini, Angelo; Sallerin, Brigitte; Girod Fullana, Sophie

    2014-01-01

    Three-dimensional (3D) scaffolds hold great potential for stem cell-based therapies. Indeed, recent results have shown that biomimetic scaffolds may enhance cell survival and promote an increase in the concentration of therapeutic cells at the injury site. The aim of this work was to engineer an original polymeric scaffold based on the respective beneficial effects of alginate and chitosan. Formulations were made from various alginate/chitosan ratios to form opposite-charge polyelectrolyte co...

  13. A client-centred, occupation-based occupational therapy programme for adults with psychiatric diagnoses.

    Science.gov (United States)

    Schindler, Victoria P

    2010-09-01

    The purpose of this study was to assess the effectiveness of a client-centred, occupation-based occupational therapy programme for individuals with psychiatric diagnoses. The study took place in a college campus. A pre-test/post-test design was used. There were 38 participants which included college students and community members who desired to attend college, work and/or address life skill goals. The Canadian Occupational Performance Measure (COPM) was used as a pre- and post-test measure. Goals were based on problems identified in the COPM, reflected academic, vocational, life skill, and leisure goals, and were systematically addressed weekly through activities developed by the participant and a graduate occupational therapy student who acted as a mentor. The Participant Overall Satisfaction Scale was completed by each participant. A case study was used to describe the programme in more depth. The results support that the client-centred, occupation-based occupational therapy programme increased client scores on satisfaction and performance of occupational performance problems identified on the COPM. Further research is recommended to explore how client-centred occupational therapy programmes can be effective in improving academic, vocational and life skill goals. Copyright 2010 John Wiley & Sons, Ltd.

  14. On the cost-effectiveness of Carbon ion radiation therapy for skull base chordoma

    International Nuclear Information System (INIS)

    Jaekel, Oliver; Land, Beate; Combs, Stephanie Elisabeth; Schulz-Ertner, Daniela; Debus, Juergen

    2007-01-01

    Aim: The cost-effectiveness of Carbon ion radiotherapy (RT) for patients with skull base chordoma is analyzed. Materials and Methods: Primary treatment costs and costs for recurrent tumors are estimated. The costs for treatment of recurrent tumors were estimated using a sample of 10 patients presenting with recurrent chordoma at the base of skull at DKFZ. Using various scenarios for the local control rate and reimbursements of Carbon ion therapy the cost-effectiveness of ion therapy for these tumors is analyzed. Results: If local control rate for skull base chordoma achieved with carbon ion therapy exceeds 70.3%, the overall treatment costs for carbon RT are lower than for conventional RTI. The cost-effectiveness ratio for carbon RT is 2539 Euro per 1% increase in survival, or 7692 Euro per additional life year. Conclusion: Current results support the thesis that Carbon ion RT, although more expensive, is at least as cost-effective as advanced photon therapies for these patients. Ion RT, however, offers substantial benefits for the patients such as improved control rates and less severe side effects

  15. Automatic speech recognition (ASR) based approach for speech therapy of aphasic patients: A review

    Science.gov (United States)

    Jamal, Norezmi; Shanta, Shahnoor; Mahmud, Farhanahani; Sha'abani, MNAH

    2017-09-01

    This paper reviews the state-of-the-art an automatic speech recognition (ASR) based approach for speech therapy of aphasic patients. Aphasia is a condition in which the affected person suffers from speech and language disorder resulting from a stroke or brain injury. Since there is a growing body of evidence indicating the possibility of improving the symptoms at an early stage, ASR based solutions are increasingly being researched for speech and language therapy. ASR is a technology that transfers human speech into transcript text by matching with the system's library. This is particularly useful in speech rehabilitation therapies as they provide accurate, real-time evaluation for speech input from an individual with speech disorder. ASR based approaches for speech therapy recognize the speech input from the aphasic patient and provide real-time feedback response to their mistakes. However, the accuracy of ASR is dependent on many factors such as, phoneme recognition, speech continuity, speaker and environmental differences as well as our depth of knowledge on human language understanding. Hence, the review examines recent development of ASR technologies and its performance for individuals with speech and language disorders.

  16. RETRIEVAL EQUIPMENT DESCRIPTIONS

    International Nuclear Information System (INIS)

    J. Steinhoff

    1997-01-01

    The objective and the scope of this document are to list and briefly describe the major mobile equipment necessary for waste package (WP) retrieval from the proposed subsurface nuclear waste repository at Yucca Mountain. Primary performance characteristics and some specialized design features of the equipment are explained and summarized in the individual subsections of this document. There are no quality assurance requirements or QA controls in this document. Retrieval under normal conditions is accomplished with the same fleet of equipment as is used for emplacement. Descriptions of equipment used for retrieval under normal conditions is found in Emplacement Equipment Descriptions, DI: BCAF00000-01717-5705-00002 (a document in progress). Equipment used for retrieval under abnormal conditions is addressed in this document and consists of the following: (1) Inclined Plane Hauler; (2) Bottom Lift Transporter; (3) Load Haul Dump (LHD) Loader; (4) Heavy Duty Forklift for Emplacement Drifts; (5) Covered Shuttle Car; (6) Multipurpose Vehicle; and (7) Scaler

  17. Cancer rehabilitation with a focus on evidence-based outpatient physical and occupational therapy interventions.

    Science.gov (United States)

    Silver, Julie K; Gilchrist, Laura S

    2011-05-01

    Cancer rehabilitation is an important part of survivorship as a distinct phase of treatment. Although cancer rehabilitation may involve many disciplines, this article specifically covers evidence-based treatment in physical and occupational therapy. Patients may need physical and occupational therapy services for a variety of cancer-related or cancer-treatment-related problems, including pain, fatigue, deconditioning, and difficulty with gait. They may also have problems resuming their previous level of function, which can impact on activities of daily living, instrumental activities of daily living, return to previous home and community activity levels, and return to work. This review discusses the role of physical and occupational therapy in helping cancer patients improve pain and musculoskeletal issues, deconditioning and endurance effects, fatigue, balance and falls, and lymphedema and psychosocial problems.

  18. Evidence-based practice in women's health: hormone therapy for women at menopause.

    Science.gov (United States)

    Rousseau, M E

    2001-01-01

    Women's health providers, especially midwives, must take into account the known benefits and risks, as well as the "unknown," when recommending the use of hormone therapy for menopausal women, especially as it relates to heart disease, breast cancer, impaired cognition, and osteoporosis. The most recent evidence available from various studies about the benefits and risks of estrogen and hormone therapy at menopause suggests that, although hormone therapy may be protective in some women against heart disease and osteoporosis, evidence is less certain about the benefits of hormone protection against impaired cognition and the risks of breast cancer with use. The clinical approach used by midwives in which individualizing care based on each woman's health status history as well as preferences is highly appropriate for women in the perimenopausal and menopausal period.

  19. Simulation-based education: A narrative review of the use of VERT in radiation therapy education.

    Science.gov (United States)

    Kane, Paul

    2018-04-14

    Simulation has a long history in medical and health science training and education. The literature describing this history is extensive. The role simulation plays in many health disciplines has evolved, as has the focus of the literature around it. The Virtual Environment for Radiotherapy Training (VERT) system is a relative newcomer to radiation therapy education and, similar to the literature around radiation therapy (RT) education, is still in its infancy. This narrative review sets the scene of simulation-based education within the health sciences and considers the lessons learned from published work on VERT to date. The evidence suggests that future inquiry involving VERT should explore different ways in which VERT can be used to contribute to the skillset required by the radiation therapist of tomorrow. © 2018 The Authors. Journal of Medical Radiation Sciences published by John Wiley & Sons Australia, Ltd on behalf of Australian Society of Medical Imaging and Radiation Therapy and New Zealand Institute of Medical Radiation Technology.

  20. Comparing telehealth-based and clinic-based group cognitive behavioral therapy for adults with depression and anxiety: a pilot study

    Directory of Open Access Journals (Sweden)

    Khatri N

    2014-05-01

    Full Text Available Nasreen Khatri, Elsa Marziali, Illia Tchernikov, Nancy ShepherdRotman Research Institute, Toronto, ON, CanadaBackground: The primary objective of this pilot study was to demonstrate reliable adherence to a group cognitive behavioral (CBT therapy protocol when delivered using on-line video conferencing as compared with face-to-face delivery of group CBT. A secondary aim was to show comparability of changes in subject depression inventory scores between on-line and face-to-face delivery of group CBT.Methods: We screened 31 individuals, 18 of whom met the criteria for a DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition diagnosis of mood and/or anxiety disorder. All qualifying participants had the necessary equipment (computer, webcam, Internet for participation in the study, but could exercise their preference for either the on-line or face-to-face format. Eighteen completed the 13 weekly session intervention program (ten face-to-face; eight video conferencing. We coded adherence to protocol in both intervention formats and generated pre–post changes in scores on the Beck Depression Inventory Second Edition (BDI-II for each participant.Results: Application of the CBT protocol coding system showed reliable adherence to the group CBT intervention protocol in both delivery formats. Similarly, qualitative analysis of the themes in group discussion indicated that both groups addressed similar issues. Pre–post intervention scores for the BDI-II were comparable across the two delivery formats, with 60% of participants in each group showing a positive change in BDI-II severity classification (eg, from moderate to low symptoms.Conclusion: This pilot study demonstrates that group CBT could be delivered in a technology-supported environment (on-line video conferencing and can meet the same professional practice standards and outcomes as face-to-face delivery of the intervention program.Keywords: psychotherapy, gerontology, mood

  1. Occupational Therapy in Medicaid Home and Community-Based Services Waivers.

    Science.gov (United States)

    Friedman, Carli; VanPuymbrouck, Laura

    Medicaid Home and Community-Based Services (HCBS) 1915(c) waivers are the largest provider of long-term services and supports for people with intellectual and developmental disabilities (IDDs). In this study, we explored how HCBS IDD waivers projected providing occupational therapy services in Fiscal Year (FY) 2015. Medicaid HCBS IDD waivers across the nation gathered from the Centers for Medicare and Medicaid Services were qualitatively and quantitatively analyzed to determine how they projected providing occupational therapy services in terms of service expenditures and utilization. In FY 2015, $14.13 million of spending was projected for occupational therapy services of 7,500 participants. However, there was large heterogeneity across states and services in terms of total projected spending, spending per participant, and reimbursement rates. Comparisons across states strengthen the profession's ability to assert the value of its services. These findings can help identify best practices and can advocate for the refinement of state occupational therapy programs. Copyright © 2018 by the American Occupational Therapy Association, Inc.

  2. Nutrition Therapy for Liver Diseases Based on the Status of Nutritional Intake

    Directory of Open Access Journals (Sweden)

    Kenichiro Yasutake

    2012-01-01

    Full Text Available The dietary intake of patients with nonalcoholic fatty liver disease (NAFLD is generally characterized by high levels of carbohydrate, fat, and/or cholesterol, and these dietary patterns influence hepatic lipid metabolism in the patients. Therefore, careful investigation of dietary habits could lead to better nutrition therapy in NAFLD patients. The main treatment for chronic hepatitis C (CHC is interferon-based antiviral therapy, which often causes a decrease in appetite and energy intake; hence, nutritional support is also required during therapy to prevent undernourishment, treatment interruption, and a reduction in quality of life. Moreover, addition of some nutrients that act to suppress viral proliferation is recommended. As a substitutive treatment, low-iron diet therapy, which is relatively safe and effective for preventing hepatocellular carcinoma, is also recommended for CHC patients. Some patients with liver cirrhosis (LC have decreased dietary energy and protein intake, while the number of LC patients with overeating and obesity is increasing, indicating that the nutritional state of LC patients has a broad spectrum. Therefore, nutrition therapy for LC patients should be planned on an assessment of their complications, nutritional state, and dietary intake. Late evening snacks, branched-chain amino acids, zinc, and probiotics are considered for effective nutritional utilization.

  3. Segmentation of tumor ultrasound image in HIFU therapy based on texture and boundary encoding

    International Nuclear Information System (INIS)

    Zhang, Dong; Xu, Menglong; Quan, Long; Yang, Yan; Qin, Qianqing; Zhu, Wenbin

    2015-01-01

    It is crucial in high intensity focused ultrasound (HIFU) therapy to detect the tumor precisely with less manual intervention for enhancing the therapy efficiency. Ultrasound image segmentation becomes a difficult task due to signal attenuation, speckle effect and shadows. This paper presents an unsupervised approach based on texture and boundary encoding customized for ultrasound image segmentation in HIFU therapy. The approach oversegments the ultrasound image into some small regions, which are merged by using the principle of minimum description length (MDL) afterwards. Small regions belonging to the same tumor are clustered as they preserve similar texture features. The mergence is completed by obtaining the shortest coding length from encoding textures and boundaries of these regions in the clustering process. The tumor region is finally selected from merged regions by a proposed algorithm without manual interaction. The performance of the method is tested on 50 uterine fibroid ultrasound images from HIFU guiding transducers. The segmentations are compared with manual delineations to verify its feasibility. The quantitative evaluation with HIFU images shows that the mean true positive of the approach is 93.53%, the mean false positive is 4.06%, the mean similarity is 89.92%, the mean norm Hausdorff distance is 3.62% and the mean norm maximum average distance is 0.57%. The experiments validate that the proposed method can achieve favorable segmentation without manual initialization and effectively handle the poor quality of the ultrasound guidance image in HIFU therapy, which indicates that the approach is applicable in HIFU therapy. (paper)

  4. The efficacy of levofloxacin-based triple therapy for first-line Helicobacter pylori eradication

    Directory of Open Access Journals (Sweden)

    Yusuf Aydın

    2011-06-01

    Full Text Available Standard triple therapy composed of a proton pump inhibitor, clarithromycin and amoxicillin has been widely preferred for H. pylori eradication in Turkey and World. Alternative therapies are currently under investigation because of an increase in clarithromycin resistance. The aim of this study was to evaluate the efficacy of a levoflox-acin-containing triple therapy.Materials and methods: The study was carried out in 81 H. pylori-infected patients (52 female, 29 male with nonul-cer dyspepsia. The mean age was found 46.3 ± 13.9. Treatment was indicated with lansoprazol 30 mg b.d., amoxicil-lin 1 g b.d., and levofloxacin 500 mg daily for 7 days. H. pylori status was rechecked by (14C urea breath test 6-8 weeks after the end of therapy.Results: Totally 81 patients could complete the treatment and follow-up protocol. Effectiveness was 68%. The distrib-tions of age, gender and smoking were similar between eradicated and non-eradicated groups (p > 0.05.Conclusion: Seven-day levofloxacin based triple therapy is not very effective in the first-line treatment of H. pylori in-fection. The new treatment modalities should be investigated.

  5. Present status of unsealed radioisotope therapy in Japan based on the nation-wide questionnaire

    International Nuclear Information System (INIS)

    Oyamada, Hiyoshimaru

    1999-01-01

    In Japan, clinical application of unsealed radioisotopes is strictly regulated. Especially in the field of therapy, we are allowed to use only Na 131 I at present. Under such circumstances, the present status of therapeutic nuclear medicine in Japan was surveyed by means of a nation-wide questionnaire, conducted in 193 hospitals. Then, 113 hospitals replied to such questionnaire (recovery rate: 58.5%), and it was found that in 77 hospitals, radioisotope therapy is being performed for Graves' disease and/or thyroid cancer. The questionnaire covered the following points: for Graves' disease-the basic strategy of 131 I therapy, its indications, absorbed doses planned to be given, whether the therapy had been conducted on outpatient basis or in-patient basis, method of thyroid weight estimation, interval of administration in case of multiple doses, number of patients treated per year (1996) etc., and for thyroid cancer-strategy for thyroid remnant, the doses to be given, the maximum doses permitted by the authorities in each hospital both per day and per year, handling of highly contaminated urine in each hospital, interval of administration in case of multiple doses, number of patients treated per year (1996) etc. Also questioned were dissatisfaction with the present regulation by the authorities and/or requests for the better daily work, if any. Based on the above questionnaire, the present status of unsealed radioisotope therapy in Japan was investigated. (author)

  6. Deep Inspiration Breath Hold—Based Radiation Therapy: A Clinical Review

    Energy Technology Data Exchange (ETDEWEB)

    Boda-Heggemann, Judit, E-mail: judit.boda-heggemann@umm.de [Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim (Germany); Knopf, Antje-Christin [The Institute of Cancer Research, Royal Cancer Hospital, London (United Kingdom); Simeonova-Chergou, Anna; Wertz, Hansjörg; Stieler, Florian; Jahnke, Anika; Jahnke, Lennart; Fleckenstein, Jens; Vogel, Lena; Arns, Anna; Blessing, Manuel; Wenz, Frederik; Lohr, Frank [Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim (Germany)

    2016-03-01

    Several recent developments in linear accelerator–based radiation therapy (RT) such as fast multileaf collimators, accelerated intensity modulation paradigms like volumeric modulated arc therapy and flattening filter-free (FFF) high-dose-rate therapy have dramatically shortened the duration of treatment fractions. Deliverable photon dose distributions have approached physical complexity limits as a consequence of precise dose calculation algorithms and online 3-dimensional image guided patient positioning (image guided RT). Simultaneously, beam quality and treatment speed have continuously been improved in particle beam therapy, especially for scanned particle beams. Applying complex treatment plans with steep dose gradients requires strategies to mitigate and compensate for motion effects in general, particularly breathing motion. Intrafractional breathing-related motion results in uncertainties in dose delivery and thus in target coverage. As a consequence, generous margins have been used, which, in turn, increases exposure to organs at risk. Particle therapy, particularly with scanned beams, poses additional problems such as interplay effects and range uncertainties. Among advanced strategies to compensate breathing motion such as beam gating and tracking, deep inspiration breath hold (DIBH) gating is particularly advantageous in several respects, not only for hypofractionated, high single-dose stereotactic body RT of lung, liver, and upper abdominal lesions but also for normofractionated treatment of thoracic tumors such as lung cancer, mediastinal lymphomas, and breast cancer. This review provides an in-depth discussion of the rationale and technical implementation of DIBH gating for hypofractionated and normofractionated RT of intrathoracic and upper abdominal tumors in photon and proton RT.

  7. Novel methodology to perform sulfur hexafluoride (SF6)-based multiple-breath wash-in and washout in infants using current commercially available equipment.

    Science.gov (United States)

    Gustafsson, P M; Robinson, P D; Lindblad, A; Oberli, D

    2016-11-01

    Multiple-breath inert gas washout (MBW) is ideally suited for early detection and monitoring of serious lung disease, such as cystic fibrosis, in infants and young children. Validated commercial options for the MBW technique are limited, and suitability of nitrogen (N 2 )-based MBW is of concern given the detrimental effect of exposure to pure O 2 on infant breathing pattern. We propose novel methodology using commercially available N 2 MBW equipment to facilitate 4% sulfur hexafluoride (SF 6 ) multiple-breath inert gas wash-in and washout suitable for the infant age range. CO 2 , O 2 , and sidestream molar mass sensor signals were used to accurately calculate SF 6 concentrations. An improved dynamic method for synchronization of gas and respiratory flow was developed to take into account variations in sidestream sample flow during MBW measurement. In vitro validation of triplicate functional residual capacity (FRC) assessments was undertaken under dry ambient conditions using lung models ranging from 90 to 267 ml, with tidal volumes of 28-79 ml, and respiratory rates 20-60 per minute. The relative mean (SD, 95% confidence interval) error of triplicate FRC determinations by washout was -0.26 (1.84, -3.86 to +3.35)% and by wash-in was 0.57 (2.66, -4.66 to +5.79)%. The standard deviations [mean (SD)] of percentage error among FRC triplicates were 1.40 (1.14) and 1.38 (1.32) for washout and wash-in, respectively. The novel methodology presented achieved FRC accuracy as outlined by current MBW consensus recommendations (95% of measurements within 5% accuracy). Further clinical evaluation is required, but this new technique, using existing commercially available equipment, has exciting potential for research and clinical use. Copyright © 2016 the American Physiological Society.

  8. [Development and evaluation of a dance-based exercise therapy for patients with haemophilia].

    Science.gov (United States)

    Czepa, D; van Ravenstein, S; Stäuber, F; Hilberg, T

    2013-01-01

    So far, the use of methods derived from creative arts has not been considered in the haemophilia treatment. The AIM was to investigate the expectations for a dance-based exercise therapy for patients with haemophilia and the extent of its acceptance. The one-hour dance-based exercise therapy was offered to 30 haemophilia patients (HI30) (49 ± 11, 30-67 years). For the evaluation of expectations, questionnaires were created and filled out by participants before and after the intervention. Additionally, 19 haemophilia patients (HF) and 20 controls without haemophilia (KF) who did not participate in the intervention were also questioned. The RESULTS show that haemophilia patients have more experience in dance than controls (HI30:62%, HF:74%, KF:45%). In contrast, the proportion of those who are currently dancing is higher in controls without haemophilia (HI30: 17%, HF: 10%, KF:26%). The termination of dance activity in patients with haemophilia who were part of the intervention was mainly due to pain (HI30: 40%, HF: 29%, KF: 0%), whereby controls without intervention terminated the dance activity mainly due to lack of time (HI30: 30%, HF: 57%, KF: 56%). Ultimately, 24 out of 30 patients with haemophilia (HI24) completed the intervention. All HI24 met their expectations. 38% felt limited by haemophilia while carrying out the exercises. The majority of the participants were able to follow the exercises well (96%) and were did not overstrain physically (92%) nor mentally (87%), also 79% did not have pain. 23 of HI24 (96%) can envision a continuation of the dance-based exercise therapy. The experience with the dance-based exercise therapy was predominantly positive. It represents an alternative sports therapy programme for patients with haemophilia. Further studies are needed in order to make statements concerning the long-term use of such training.

  9. Medical equipment management

    CERN Document Server

    Willson, Keith; Tabakov, Slavik

    2013-01-01

    Know What to Expect When Managing Medical Equipment and Healthcare Technology in Your Organization As medical technology in clinical care becomes more complex, clinical professionals and support staff must know how to keep patients safe and equipment working in the clinical environment. Accessible to all healthcare professionals and managers, Medical Equipment Management presents an integrated approach to managing medical equipment in healthcare organizations. The book explains the underlying principles and requirements and raises awareness of what needs to be done and what questions to ask. I

  10. Data communication equipment

    International Nuclear Information System (INIS)

    Kim, Hak Seon; Lee, Sang Mok

    1998-02-01

    The contents of this book are introduction of data communication on definition, purpose and history, information terminal about data communication system and data transmission system, data transmit equipment of summary, transmission cable, data port, concentrator and front-end processor, audio communication equipment like phones, radio communication equipment of summary on foundation of electromagnetic waves, AM transmitter, AM receiver, FM receiver and FM transmitter, a satellite and mobile communication equipment such as earth station, TT and C and Cellular phone, video telephone and new media apparatus.

  11. Hydraulic turbines and auxiliary equipment

    Energy Technology Data Exchange (ETDEWEB)

    Luo Gaorong [Organization of the United Nations, Beijing (China). International Centre of Small Hydroelectric Power Plants

    1995-07-01

    This document presents a general overview on hydraulic turbines and auxiliary equipment, emphasizing the turbine classification, in accordance with the different types of turbines, standard turbine series in China, turbine selection based on the basic data required for the preliminary design, general hill model curves, chart of turbine series and the arrangement of application for hydraulic turbines, hydraulic turbine testing, and speed regulating device.

  12. Nanoparticle-Based Drug Delivery for Therapy of Lung Cancer: Progress and Challenges

    Directory of Open Access Journals (Sweden)

    Anish Babu

    2013-01-01

    Full Text Available The last decade has witnessed enormous advances in the development and application of nanotechnology in cancer detection, diagnosis, and therapy culminating in the development of the nascent field of “cancer nanomedicine.” A nanoparticle as per the National Institutes of Health (NIH guidelines is any material that is used in the formulation of a drug resulting in a final product smaller than 1 micron in size. Nanoparticle-based therapeutic systems have gained immense popularity due to their ability to overcome biological barriers, effectively deliver hydrophobic therapies, and preferentially target disease sites. Currently, many formulations of nanocarriers are utilized including lipid-based, polymeric and branched polymeric, metal-based, magnetic, and mesoporous silica. Innovative strategies have been employed to exploit the multicomponent, three-dimensional constructs imparting multifunctional capabilities. Engineering such designs allows simultaneous drug delivery of chemotherapeutics and anticancer gene therapies to site-specific targets. In lung cancer, nanoparticle-based therapeutics is paving the way in the diagnosis, imaging, screening, and treatment of primary and metastatic tumors. However, translating such advances from the bench to the bedside has been severely hampered by challenges encountered in the areas of pharmacology, toxicology, immunology, large-scale manufacturing, and regulatory issues. This review summarizes current progress and challenges in nanoparticle-based drug delivery systems, citing recent examples targeted at lung cancer treatment.

  13. Mesenchymal stem cell-based gene therapy: A promising therapeutic strategy.

    Science.gov (United States)

    Mohammadian, Mozhdeh; Abasi, Elham; Akbarzadeh, Abolfazl

    2016-08-01

    Mesenchymal stem cells (MSCs) are multipotent stromal cells that exist in bone marrow, fat, and so many other tissues, and can differentiate into a variety of cell types including osteoblasts, chondrocytes, and adipocytes, as well as myocytes and neurons. Moreover, they have great capacity for self-renewal while maintaining their multipotency. Their capacity for proliferation and differentiation, in addition to their immunomodulatory activity, makes them very promising candidates for cell-based regenerative medicine. Moreover, MSCs have the ability of mobilization to the site of damage; therefore, they can automatically migrate to the site of injury via their chemokine receptors following intravenous transplantation. In this respect, they can be applied for MSC-based gene therapy. In this new therapeutic method, genes of interest are introduced into MSCs via viral and non-viral-based methods that lead to transgene expression in them. Although stem cell-based gene therapy is a relatively new strategy, it lights a new hope for the treatment of a variety of genetic disorders. In the near future, MSCs can be of use in a vast number of clinical applications, because of their uncomplicated isolation, culture, and genetic manipulation. However, full consideration is still crucial before they are utilized for clinical trials, because the number of studies that signify the advantageous effects of MSC-based gene therapy are still limited.

  14. Facial asymmetry correction with moulded helmet therapy in infants with deformational skull base plagiocephaly.

    Science.gov (United States)

    Kreutz, Matthias; Fitze, Brigitte; Blecher, Christoph; Marcello, Augello; Simon, Ruben; Cremer, Rebecca; Zeilhofer, Hans-Florian; Kunz, Christoph; Mayr, Johannes

    2018-01-01

    The recommendation issued by the American Academy of Pediatrics in the early 1990s to position infants on their back during sleep to prevent sudden infant death syndrome (SIDS) has dramatically reduced the number of deaths due to SIDS but has also markedly increased the prevalence of positional skull deformation in infants. Deformation of the base of the skull occurs predominantly in very severe deformational plagiocephaly and is accompanied by facial asymmetry, as well as an altered ear position, called ear shift. Moulded helmet therapy has become an accepted treatment strategy for infants with deformational plagiocephaly. The aim of this study was to determine whether facial asymmetry could be corrected by moulded helmet therapy. In this retrospective, single-centre study, we analysed facial asymmetry of 71 infants with severe deformational plagiocephaly with or without deformational brachycephaly who were undergoing moulded helmet therapy between 2009 and 2013. Computer-assisted, three-dimensional, soft-tissue photographic scanning was used to record the head shape before and after moulded helmet therapy. The distance between two landmarks in the midline of the face (i.e., root of the nose and nasal septum) and the right and left tragus were measured on computer-generated indirect and objective 3D photogrammetry images. A quotient was calculated between the two right- and left-sided distances to the midline. Quotients were compared before and after moulded helmet therapy. Infants without any therapy served as a control group. The median age of the infants before onset of moulded helmet therapy was 5 months (range 3-16 months). The median duration of moulded helmet therapy was 5 months (range 1-16 months). Comparison of the pre- and post-treatment quotients of the left vs. right distances measured between the tragus and root of the nose (n = 71) and nasal septum (n = 71) revealed a significant reduction of the asymmetry (Tragus-Nasion-Line Quotient: 0

  15. Therapies for children with cerebral palsy A Web of Science-based literature analysis

    Institute of Scientific and Technical Information of China (English)

    Yaping Mu; Na Li; Lijun Guan; Chunnan Wang; Shuyun Shang; Yan Wang

    2012-01-01

    OBJECTIVE:To identify global research trends in three therapies for children with cerebral palsy.DATA RETRIEVAL:We performed a bibliometric analysis of studies on therapies for children with cerebral palsy from 2002 to 2011 retrieved from Web of Science.SELECTION CRITERIA:Inclusion criteria:(a)peer-reviewed published articles on botulinum toxin,constraint-induced movement therapy,or acupuncture for children with cerebral palsy indexed in Web of Science;(b)original research articles,reviews,meeting abstracts,proceedings papers,book chapters,editorial material,and news items;and(c)publication between 2002 and 2011.Exclusion criteria:(a)articles that required manual searching or telephone access;(b)documents that were not published in the public domain;and(c)a number of corrected papers from the total number of articles.MAIN OUTCOME MEASURES:(1)Number of publications on the three therapies;(2)annual publication output,distribution by journals,distribution by institution,and top-cited articles on botulinum toxin;(3)annual publication output,distribution by journal,distribution by institution,and top-cited articles on constraint-induced movement therapy;(4)annual publication,distribution by journal,distribution by institution,and top-cited articles on acupuncture.RESULTS:This analysis,based on Web of Science articles,identified several research trends in studies published over the past 10 years of three therapies for children with cerebral palsy.More articles on botulinum toxin for treating children with cerebral palsy were published than the articles regarding constraint-induced movement therapy or acupuncture.The numbers of publications increased over the 10-year study period.Most papers appeared in journals with a focus on neurology,such as Developmental Medicine and Child Neurology and Journal of Child Neurology.Research institutes publishing on botulinum toxin treatments for this population are mostly in the Netherlands,the United States of America,and Australia

  16. Current concepts in F18 FDG PET/CT-based Radiation Therapy planning for Lung Cancer

    Directory of Open Access Journals (Sweden)

    Percy eLee

    2012-07-01

    Full Text Available Radiation therapy is an important component of cancer therapy for early stage as well as locally advanced lung cancer. The use of F18 FDG PET/CT has come to the forefront of lung cancer staging and overall treatment decision-making. FDG PET/CT parameters such as standard uptake value and metabolic tumor volume provide important prognostic and predictive information in lung cancer. Importantly, FDG PET/CT for radiation planning has added biological information in defining the gross tumor volume as well as involved nodal disease. For example, accurate target delineation between tumor and atelectasis is facilitated by utilizing PET and CT imaging. Furthermore, there has been meaningful progress in incorporating metabolic information from FDG PET/CT imaging in radiation treatment planning strategies such as radiation dose escalation based on standard uptake value thresholds as well as using respiratory gated PET and CT planning for improved target delineation of moving targets. In addition, PET/CT based follow-up after radiation therapy has provided the possibility of early detection of local as well as distant recurrences after treatment. More research is needed to incorporate other biomarkers such as proliferative and hypoxia biomarkers in PET as well as integrating metabolic information in adaptive, patient-centered, tailored radiation therapy.

  17. Potential mechanisms for cell-based gene therapy to treat HIV/AIDS.

    Science.gov (United States)

    Herrera-Carrillo, Elena; Berkhout, Ben

    2015-02-01

    An estimated 35 million people are infected with HIV worldwide. Anti-retroviral therapy (ART) has reduced the morbidity and mortality of HIV-infected patients but efficacy requires strict adherence and the treatment is not curative. Most importantly, the emergence of drug-resistant virus strains and drug toxicity can restrict the long-term therapeutic efficacy in some patients. Therefore, novel treatment strategies that permanently control or eliminate the virus and restore the damaged immune system are required. Gene therapy against HIV infection has been the topic of intense investigations for the last two decades because it can theoretically provide such a durable anti-HIV control. In this review we discuss two major gene therapy strategies to combat HIV. One approach aims to kill HIV-infected cells and the other is based on the protection of cells from HIV infection. We discuss the underlying molecular mechanisms for candidate approaches to permanently block HIV infection, including the latest strategies and future therapeutic applications. Hematopoietic stem cell-based gene therapy for HIV/AIDS may eventually become an alternative for standard ART and should ideally provide a functional cure in which the virus is durably controlled without medication. Recent results from preclinical research and early-stage clinical trials support the feasibility and safety of this novel strategy.

  18. Recent insights in nanotechnology-based drugs and formulations designed for effective anti-cancer therapy.

    Science.gov (United States)

    Piktel, Ewelina; Niemirowicz, Katarzyna; Wątek, Marzena; Wollny, Tomasz; Deptuła, Piotr; Bucki, Robert

    2016-05-26

    The rapid development of nanotechnology provides alternative approaches to overcome several limitations of conventional anti-cancer therapy. Drug targeting using functionalized nanoparticles to advance their transport to the dedicated site, became a new standard in novel anti-cancer methods. In effect, the employment of nanoparticles during design of antineoplastic drugs helps to improve pharmacokinetic properties, with subsequent development of high specific, non-toxic and biocompatible anti-cancer agents. However, the physicochemical and biological diversity of nanomaterials and a broad spectrum of unique features influencing their biological action requires continuous research to assess their activity. Among numerous nanosystems designed to eradicate cancer cells, only a limited number of them entered the clinical trials. It is anticipated that progress in development of nanotechnology-based anti-cancer materials will provide modern, individualized anti-cancer therapies assuring decrease in morbidity and mortality from cancer diseases. In this review we discussed the implication of nanomaterials in design of new drugs for effective antineoplastic therapy and describe a variety of mechanisms and challenges for selective tumor targeting. We emphasized the recent advantages in the field of nanotechnology-based strategies to fight cancer and discussed their part in effective anti-cancer therapy and successful drug delivery.

  19. Determining diabetic retinopathy screening interval based on time from no retinopathy to laser therapy.

    Science.gov (United States)

    Hughes, Daniel; Nair, Sunil; Harvey, John N

    2017-12-01

    Objectives To determine the necessary screening interval for retinopathy in diabetic patients with no retinopathy based on time to laser therapy and to assess long-term visual outcome following screening. Methods In a population-based community screening programme in North Wales, 2917 patients were followed until death or for approximately 12 years. At screening, 2493 had no retinopathy; 424 had mostly minor degrees of non-proliferative retinopathy. Data on timing of first laser therapy and visual outcome following screening were obtained from local hospitals and ophthalmology units. Results Survival analysis showed that very few of the no retinopathy at screening group required laser therapy in the early years compared with the non-proliferative retinopathy group ( p retinopathy at screening group required laser therapy, and at three years 0.2% (cumulative), lower rates of treatment than have been suggested by analyses of sight-threatening retinopathy determined photographically. At follow-up (mean 7.8 ± 4.6 years), mild to moderate visual impairment in one or both eyes due to diabetic retinopathy was more common in those with retinopathy at screening (26% vs. 5%, p diabetes occurred in only 1 in 1000. Conclusions Optimum screening intervals should be determined from time to active treatment. Based on requirement for laser therapy, the screening interval for diabetic patients with no retinopathy can be extended to two to three years. Patients who attend for retinal screening and treatment who have no or non-proliferative retinopathy now have a very low risk of eventual blindness from diabetes.

  20. A Split-and-Merge-Based Uterine Fibroid Ultrasound Image Segmentation Method in HIFU Therapy.

    Directory of Open Access Journals (Sweden)

    Menglong Xu

    Full Text Available High-intensity focused ultrasound (HIFU therapy has been used to treat uterine fibroids widely and successfully. Uterine fibroid segmentation plays an important role in positioning the target region for HIFU therapy. Presently, it is completed by physicians manually, reducing the efficiency of therapy. Thus, computer-aided segmentation of uterine fibroids benefits the improvement of therapy efficiency. Recently, most computer-aided ultrasound segmentation methods have been based on the framework of contour evolution, such as snakes and level sets. These methods can achieve good performance, although they need an initial contour that influences segmentation results. It is difficult to obtain the initial contour automatically; thus, the initial contour is always obtained manually in many segmentation methods. A split-and-merge-based uterine fibroid segmentation method, which needs no initial contour to ensure less manual intervention, is proposed in this paper. The method first splits the image into many small homogeneous regions called superpixels. A new feature representation method based on texture histogram is employed to characterize each superpixel. Next, the superpixels are merged according to their similarities, which are measured by integrating their Quadratic-Chi texture histogram distances with their space adjacency. Multi-way Ncut is used as the merging criterion, and an adaptive scheme is incorporated to decrease manual intervention further. The method is implemented using Matlab on a personal computer (PC platform with Intel Pentium Dual-Core CPU E5700. The method is validated on forty-two ultrasound images acquired from HIFU therapy. The average running time is 9.54 s. Statistical results showed that SI reaches a value as high as 87.58%, and normHD is 5.18% on average. It has been demonstrated that the proposed method is appropriate for segmentation of uterine fibroids in HIFU pre-treatment imaging and planning.

  1. Individualized Positron Emission Tomography–Based Isotoxic Accelerated Radiation Therapy Is Cost-Effective Compared With Conventional Radiation Therapy: A Model-Based Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Bongers, Mathilda L., E-mail: ml.bongers@vumc.nl [Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam (Netherlands); Coupé, Veerle M.H. [Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam (Netherlands); De Ruysscher, Dirk [Radiation Oncology University Hospitals Leuven/KU Leuven, Leuven (Belgium); Department of Radiation Oncology, GROW Research Institute, Maastricht University Medical Center, Maastricht (Netherlands); Oberije, Cary; Lambin, Philippe [Department of Radiation Oncology, GROW Research Institute, Maastricht University Medical Center, Maastricht (Netherlands); Uyl-de Groot, Cornelia A. [Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam (Netherlands); Institute for Medical Technology Assessment, Erasmus University Rotterdam, Rotterdam (Netherlands)

    2015-03-15

    Purpose: To evaluate long-term health effects, costs, and cost-effectiveness of positron emission tomography (PET)-based isotoxic accelerated radiation therapy treatment (PET-ART) compared with conventional fixed-dose CT-based radiation therapy treatment (CRT) in non-small cell lung cancer (NSCLC). Methods and Materials: Our analysis uses a validated decision model, based on data of 200 NSCLC patients with inoperable stage I-IIIB. Clinical outcomes, resource use, costs, and utilities were obtained from the Maastro Clinic and the literature. Primary model outcomes were the difference in life-years (LYs), quality-adjusted life-years (QALYs), costs, and the incremental cost-effectiveness and cost/utility ratio (ICER and ICUR) of PET-ART versus CRT. Model outcomes were obtained from averaging the predictions for 50,000 simulated patients. A probabilistic sensitivity analysis and scenario analyses were carried out. Results: The average incremental costs per patient of PET-ART were €569 (95% confidence interval [CI] €−5327-€6936) for 0.42 incremental LYs (95% CI 0.19-0.61) and 0.33 QALYs gained (95% CI 0.13-0.49). The base-case scenario resulted in an ICER of €1360 per LY gained and an ICUR of €1744 per QALY gained. The probabilistic analysis gave a 36% probability that PET-ART improves health outcomes at reduced costs and a 64% probability that PET-ART is more effective at slightly higher costs. Conclusion: On the basis of the available data, individualized PET-ART for NSCLC seems to be cost-effective compared with CRT.

  2. Interpersonal Problems, Mindfulness, and Therapy Outcome in an Acceptance-Based Behavior Therapy for Generalized Anxiety Disorder.

    Science.gov (United States)

    Millstein, Daniel J; Orsillo, Susan M; Hayes-Skelton, Sarah A; Roemer, Lizabeth

    2015-01-01

    To better understand the role interpersonal problems play in response to two treatments for generalized anxiety disorder (GAD); an acceptance-based behavior therapy (ABBT) and applied relaxation (AR), and to examine how the development of mindfulness may be related to change in interpersonal problems over treatment and at follow-up. Eighty-one individuals diagnosed with GAD (65.4% female, 80.2% identified as white, average age 32.92) were randomized to receive 16 sessions of either ABBT or AR. GAD severity, interpersonal problems, and mindfulness were measured at pre-treatment, post-treatment, 6-month follow-up, and 12-month follow-up. Mixed effect regression models did not reveal any significant effects of pre-treatment interpersonal problems on GAD severity over treatment. After controlling for post-treatment GAD severity, remaining post-treatment interpersonal problems predicted 6- but not 12-month GAD severity. Participants in both conditions experienced a large decrease in interpersonal problems over treatment. Increases in mindfulness over treatment and through follow-up were associated with decreases in interpersonal problems, even when accounting for reductions in overall GAD severity. Interpersonal problems may be an important target of treatment in GAD, even if pre-treatment interpersonal problems are not predictive of outcome. Developing mindfulness in individuals with GAD may help ameliorate interpersonal difficulties among this population.

  3. Cooling of electronic equipment

    DEFF Research Database (Denmark)

    A. Kristensen, Anders Schmidt

    2003-01-01

    Cooling of electronic equipment is studied. The design size of electronic equipment decrease causing the thermal density to increase. This affect the cooling which can cause for example failures of critical components due to overheating or thermal induced stresses. Initially a pin fin heat sink...

  4. Capital Equipment Replacement Decisions

    OpenAIRE

    Batterham, Robert L.; Fraser, K.I.

    1995-01-01

    This paper reviews the literature on the optimal replacement of capital equipment, especially farm machinery. It also considers the influence of taxation and capital rationing on replacement decisions. It concludes that special taxation provisions such as accelerated depreciation and investment allowances are unlikely to greatly influence farmers' capital equipment replacement decisions in Australia.

  5. Progress and challenges in the development of a cell-based therapy for hemophilia A.

    Science.gov (United States)

    Fomin, M E; Togarrati, P P; Muench, M O

    2014-12-01

    Hemophilia A results from an insufficiency of factor VIII (FVIII). Although replacement therapy with plasma-derived or recombinant FVIII is a life-saving therapy for hemophilia A patients, such therapy is a life-long treatment rather than a cure for the disease. In this review, we discuss the possibilities, progress, and challenges that remain in the development of a cell-based cure for hemophilia A. The success of cell therapy depends on the type and availability of donor cells, the age of the host and method of transplantation, and the levels of engraftment and production of FVIII by the graft. Early therapy, possibly even prenatal transplantation, may yield the highest levels of engraftment by avoiding immunological rejection of the graft. Potential cell sources of FVIII include a specialized subset of endothelial cells known as liver sinusoidal endothelial cells (LSECs) present in the adult and fetal liver, or patient-specific endothelial cells derived from induced pluripotent stem cells that have undergone gene editing to produce FVIII. Achieving sufficient engraftment of transplanted LSECs is one of the obstacles to successful cell therapy for hemophilia A. We discuss recent results from transplants performed in animals that show production of functional and clinically relevant levels of FVIII obtained from donor LSECs. Hence, the possibility of treating hemophilia A can be envisioned through persistent production of FVIII from transplanted donor cells derived from a number of potential cell sources or through creation of donor endothelial cells from patient-specific induced pluripotent stem cells. © 2014 International Society on Thrombosis and Haemostasis.

  6. The effectiveness of laser therapy in onychomycosis patients: An evidence-based case report

    Directory of Open Access Journals (Sweden)

    Rizky Lendl Prayogo

    2017-08-01

    Full Text Available Background: Onychomycosis may cause nail discoloration, thickening, nail bed separation, and other serious complications. For some cases, oral antifungal treatment is not tolerable because of its potential side effects and drug interactions. Laser therapy is considered as an alternative treatment, owing to the features of simple and effective, with only minor potential side effects. This EBCR was made to collect and appraise studies regarding the effectiveness of laser therapy for onychomycosis, and to suggest laser as an alternative treatment. Methods: Literature searching strategy was performed using Pubmed and Cochrane Library database to address the clinical problem. Keywords used were “laser” AND “onychomycosis”. Results: Seventy-nine articles were obtained from the search strategy procedure. After selection based on exclusion and inclusion criteria, and full-text availability, four relevant articles remained. Discussion: The study by Xu et al. was considered as the most valid study while compared to other three studies. This study used intention to treat analysis and had no loss of follow-up patients. Xu et al. compared mycological and clinical clearance rate between patients receiving laser, oral terbinafine, or combination of those two. It showed that laser therapy was less effective when compared to oral antifungal (Number Needed to Harm = 17. Conclusions: Laser has a lower level of effectiveness while compared to oral terbinafine as the current gold standard therapy for onychomycosis. However, laser therapy can still be used as an adjunctive therapy along with oral antifungal to achieve a better cure rate. More studies are needed to prove this hypothesis.

  7. Progress and challenges in the development of a cell-based therapy for hemophilia A

    Science.gov (United States)

    Fomin, Marina E.; Togarrati, Padma Priya; Muench, Marcus O.

    2015-01-01

    Hemophilia A results from an insufficiency of factor VIII (FVIII). Although replacement therapy with plasma-derived or recombinant FVIII is a life-saving therapy for hemophilia A patients, such therapy is a life-long treatment rather than a cure for the disease. In this review we discuss the possibilities, progress and challenges that remain in the development of a cell-based cure for hemophilia A. The success of cell therapy depends on the type and availability of donor cells, the age of the host and method of transplantation, and the levels of engraftment and production of FVIII by the graft. Early therapy, possibly even prenatal transplantation, may yield the highest levels of engraftment by avoiding immunological rejection of the graft. Potential cell sources of FVIII include a specialized subset of endothelial cells known as liver sinusoidal endothelial cells (LSECs) present in the adult and fetal liver, or patient-specific endothelial cells derived from induced pluripotent stem cells (iPSCs) that have undergone gene editing to produce FVIII. Achieving sufficient engraftment of transplanted LSECs is one of the obstacles to successful cell therapy for hemophilia A. We discuss recent results from transplants performed in animals that show production of functional and clinically relevant levels of FVIII obtained from donor LSECs. Hence, the possibility of treating hemophilia A can be envisioned through persistent production of FVIII from transplanted donor cells derived from a number of potential cell sources or through creation of donor endothelial cells from patient-specific iPSCs. PMID:25297648

  8. Equipment Replacement Decision Making: Opportunities and Challenges

    OpenAIRE

    Fan, Wei (David); Gemar, Mason D.; Machemehl, Randy

    2012-01-01

    The primary function of equipment managers is to replace the right equipment at the right time and at the lowest overall cost. In this paper, the opportunities and challenges associated with equipment replacement optimization (ERO) are discussed in detail. First, a comprehensive review of the state-of-the art and state-of-the practice literature for the ERO problem is conducted. Second, a dynamic programming (DP) based optimization solution methodology is presented to solve the ERO problem. T...

  9. Mine railway equipments management information system

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, X.; Han, K.; Duan, T.; Liu, Z.; Lu, H. [China University of Mining and Technology, Xuzhou (China)

    2007-06-15

    Based on client/server and browser/server models, the management information system described realized the entire life-cycle management of mine railway equipment which included universal equipment and special equipment in the locomotive depot, track maintenance division, electrical depot and car depot. The system has other online functions such as transmitting reports, graphics management, statistics, searches, graphics wizard and web propaganda. It was applied in Pingdingshan Coal Co. Ltd.'s Railway Transport Department. 5 refs., 4 figs.

  10. Effects of Incretin-Based Therapies and SGLT2 Inhibitors on Skeletal Health.

    Science.gov (United States)

    Egger, Andrea; Kraenzlin, Marius E; Meier, Christian

    2016-12-01

    Anti-diabetic drugs are widely used and are essential for adequate glycemic control in patients with type 2 diabetes. Recently, marketed anti-diabetic drugs include incretin-based therapies (GLP-1 receptor agonists and DPP-4 inhibitors) and sodium-glucose co-transporter 2 (SGLT2) inhibitors. In contrast to well-known detrimental effects of thiazolidinediones on bone metabolism and fracture risk, clinical data on the safety of incretin-based therapies is limited. Based on meta-analyses of trials investigating the glycemic-lowering effect of GLP-1 receptor agonists and DPP4 inhibitors, it seems that incretin-based therapies are not associated with an increase in fracture risk. Sodium-glucose co-transporter 2 inhibitors may alter calcium and phosphate homeostasis as a result of secondary hyperparathyroidism induced by increased phosphate reabsorption. Although these changes may suggest detrimental effects of SGLT-2 inhibitors on skeletal integrity, treatment-related direct effects on bone metabolism seem unlikely. Observed changes in BMD, however, seem to result from increased bone turnover in the early phase of drug-induced weight loss. Fracture risk, which is observed in older patients with impaired renal function and elevated cardiovascular disease risk treated with SGLT2 inhibitors, seems to be independent of direct effects on bone but more likely to be associated with falls and changes in hydration status secondary to osmotic diuresis.

  11. Mindfulness-Based Therapies in the Treatment of Functional Gastrointestinal Disorders: A Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Monique Aucoin

    2014-01-01

    Full Text Available Background. Functional gastrointestinal disorders are highly prevalent and standard treatments are often unsatisfactory. Mindfulness-based therapy has shown benefit in conditions including chronic pain, mood, and somatization disorders. Objectives. To assess the quality and effectiveness reported in existing literature, we conducted a meta-analysis of mindfulness-based therapy in functional gastrointestinal disorders. Methods. Pubmed, EBSCO, and Cochrane databases were searched from inception to May 2014. Study inclusion criteria included randomized, controlled studies of adults using mindfulness-based therapy in the treatment of functional gastrointestinal disorders. Study quality was evaluated using the Cochrane risk of bias. Effect sizes were calculated and pooled to achieve a summary effect for the intervention on symptom severity and quality of life. Results. Of 119 records, eight articles, describing seven studies, met inclusion criteria. In six studies, significant improvements were achieved or maintained at the end of intervention or follow-up time points. The studies had an unclear or high risk of bias. Pooled effects were statistically significant for IBS severity (0.59, 95% CI 0.33 to 0.86 and quality of life (0.56, 95% CI 0.47 to 0.79. Conclusion. Studies suggest that mindfulness based interventions may provide benefit in functional gastrointestinal disorders; however, substantial improvements in methodological quality and reporting are needed.

  12. Platinum-based chemotherapy with or without thoracic radiation therapy in patients with unresectable thymic carcinoma

    International Nuclear Information System (INIS)

    Nakamura, Yoichi; Kunitoh, Hideo; Kubota, Kaoru

    2000-01-01

    Thymic carcinoma is a rare mediastinal neoplasm with poor prognosis. Although the clinical benefit of chemotherapy for thymic carcinoma is controversial, cisplatin-based chemotherapy with or without radiation therapy is ordinarily adopted in advanced cases. We evaluated the clinical outcome of platinum-based chemotherapy with or without radiation therapy in unresectable thymic carcinoma patients. Ten patients with unresectable thymic carcinoma were treated with platinum-based chemotherapy with or without radiation therapy in the National Cancer Center Hospital between 1989 and 1998. We reviewed the histological type, treatment, response and survival of these patients. Four of the 10 patients responded to chemotherapy and both the median progression-free survival period and the median response duration were 6.0 months. The median survival time was 11.0 months. There was no relationship between histological classification and prognosis. Platinum-based chemotherapy with or without thoracic radiation is, regardless of tumor histology, marginally effective in advanced thymic carcinoma patients, giving only a modest tumor response rate and short response duration and survival. (author)

  13. Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy.

    Science.gov (United States)

    Ganesan, Palanivel; Choi, Dong-Kug

    2016-01-01

    Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera, curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy.

  14. Automatic atlas based electron density and structure contouring for MRI-based prostate radiation therapy on the cloud

    International Nuclear Information System (INIS)

    Dowling, J A; Burdett, N; Chandra, S; Rivest-Hénault, D; Ghose, S; Salvado, O; Fripp, J; Greer, P B; Sun, J; Parker, J; Pichler, P; Stanwell, P

    2014-01-01

    Our group have been developing methods for MRI-alone prostate cancer radiation therapy treatment planning. To assist with clinical validation of the workflow we are investigating a cloud platform solution for research purposes. Benefits of cloud computing can include increased scalability, performance and extensibility while reducing total cost of ownership. In this paper we demonstrate the generation of DICOM-RT directories containing an automatic average atlas based electron density image and fast pelvic organ contouring from whole pelvis MR scans.

  15. Automatic Atlas Based Electron Density and Structure Contouring for MRI-based Prostate Radiation Therapy on the Cloud

    Science.gov (United States)

    Dowling, J. A.; Burdett, N.; Greer, P. B.; Sun, J.; Parker, J.; Pichler, P.; Stanwell, P.; Chandra, S.; Rivest-Hénault, D.; Ghose, S.; Salvado, O.; Fripp, J.

    2014-03-01

    Our group have been developing methods for MRI-alone prostate cancer radiation therapy treatment planning. To assist with clinical validation of the workflow we are investigating a cloud platform solution for research purposes. Benefits of cloud computing can include increased scalability, performance and extensibility while reducing total cost of ownership. In this paper we demonstrate the generation of DICOM-RT directories containing an automatic average atlas based electron density image and fast pelvic organ contouring from whole pelvis MR scans.

  16. The clinical relevance of cell-based therapy for the treatment of stress urinary incontinence

    DEFF Research Database (Denmark)

    Gräs, Søren; Lose, Gunnar

    2011-01-01

    or progenitor cells presents an alternative approach, which aims at repairing the anatomical components of the urethral continence mechanism. In vitro expanded progenitor cells isolated from muscle biopsies have been most intensely investigated, and both preclinical trials and a few clinical trials have......Stress urinary incontinence is a common disorder affecting the quality of life for millions of women worldwide. Effective surgical procedures involving synthetic permanent meshes exist, but significant short- and long-term complications occur. Cell-based therapy using autologous stem cells...... provided proof of concept for the idea. An initial enthusiasm caused by positive results from early clinical trials has been dampened by the recognition of scientific irregularities. At the same time, the safety issue for cell-based therapy has been highlighted by the appearance of new and comprehensive...

  17. Replacing SUs with incretin-based therapies for type 2 diabetes mellitus

    DEFF Research Database (Denmark)

    Knop, Filip K; Holst, Jens Juul; Vilsbøll, Tina

    2008-01-01

    Type 2 diabetes mellitus (T2DM) is a progressive disease characterized by insulin resistance, a steady decline in glucose-induced insulin secretion (most likely caused by a progressive decrease in functional beta-cell mass), and inappropriately regulated glucagon secretion; in combination...... are glucose-dependent, reducing the risk of hypoglycemia. GLP-1 inhibits glucagon secretion and decreases gastrointestinal motility, in turn reducing food intake and body weight. This feature review focuses on the challenges and feasibilities of replacing SU with incretin-based therapy in patients with T2DM....... - glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). More importantly, incretin-based therapies potentiate glucose-stimulated insulin secretion and may restore reduced glucose-induced insulin secretion in T2DM. Furthermore, the insulinotropic effects of GLP-1 and GIP...

  18. Radiation therapy for head and neck cancers a case-based review

    CERN Document Server

    Beyzadeoglu, Murat; Selek, Ugur

    2014-01-01

    This evidence-based guide to the current management of cancer cases at all head and neck sites will assist in the appropriate selection and delineation of tumor volumes/fields for intensity-modulated radiation therapy (IMRT), including volumetric modulated arc therapy (VMAT). Each tumor site-related chapter presents, from the perspective of an academic expert, several actual cases at different stages in order to clarify specific clinical concepts. The coverage includes case presentation, a case-related literature review, patient preparation, simulation, contouring, treatment planning, treatment delivery, and follow-up. The text is accompanied by illustrations ranging from slice-by-slice delineations on planning CT images to finalized plan evaluations based on detailed acceptance criteria. The book will be of value for residents, fellows, practicing radiation oncologists, and medical physicists interested in clinical radiation oncology.

  19. SU-F-J-194: Development of Dose-Based Image Guided Proton Therapy Workflow

    Energy Technology Data Exchange (ETDEWEB)

    Pham, R; Sun, B; Zhao, T; Li, H; Yang, D; Grantham, K; Goddu, S; Santanam, L; Bradley, J; Mutic, S; Kandlakunta, P; Zhang, T [Washington University School of Medicine, Saint Louis, MO (United States)

    2016-06-15

    Purpose: To implement image-guided proton therapy (IGPT) based on daily proton dose distribution. Methods: Unlike x-ray therapy, simple alignment based on anatomy cannot ensure proper dose coverage in proton therapy. Anatomy changes along the beam path may lead to underdosing the target, or overdosing the organ-at-risk (OAR). With an in-room mobile computed tomography (CT) system, we are developing a dose-based IGPT software tool that allows patient positioning and treatment adaption based on daily dose distributions. During an IGPT treatment, daily CT images are acquired in treatment position. After initial positioning based on rigid image registration, proton dose distribution is calculated on daily CT images. The target and OARs are automatically delineated via deformable image registration. Dose distributions are evaluated to decide if repositioning or plan adaptation is necessary in order to achieve proper coverage of the target and sparing of OARs. Besides online dose-based image guidance, the software tool can also map daily treatment doses to the treatment planning CT images for offline adaptive treatment. Results: An in-room helical CT system is commissioned for IGPT purposes. It produces accurate CT numbers that allow proton dose calculation. GPU-based deformable image registration algorithms are developed and evaluated for automatic ROI-delineation and dose mapping. The online and offline IGPT functionalities are evaluated with daily CT images of the proton patients. Conclusion: The online and offline IGPT software tool may improve the safety and quality of proton treatment by allowing dose-based IGPT and adaptive proton treatments. Research is partially supported by Mevion Medical Systems.

  20. Proton-therapy and hadron-therapy ionization chambers

    International Nuclear Information System (INIS)

    Boissonnat, Guillaume

    2015-01-01

    In the framework of the ARCHADE project (Advanced Resource Center for Hadron-therapy in Europe), a research project in Carbone ion beam therapy and clinical Proton-therapy, this work investigates the beam monitoring and dosimetry aspects of ion beam therapy. The main goal, here, is to understand the operating mode of air ionization chambers, the detectors used for such applications. This study starts at a very fundamental level as the involved physical and chemical parameters of air were measured in various electric field conditions with dedicated setups and used to produce a simulation tools aiming at reproducing the operating response in high intensity PBS (Pencil Beam Scanning) coming from IBA's (Ion Beam Applications) next generation of proton beam accelerators. In addition, an ionization chamber-based dosimetry equipment was developed, DOSION III, for radiobiology studies conducted at GANIL under the supervision of the CIMAP laboratory. (author)