WorldWideScience

Sample records for therapy beam line

  1. A beam optics study of the biomedical beam line at a proton therapy facility

    International Nuclear Information System (INIS)

    Yun, Chong Cheoul; Kim, Jong-Won

    2007-01-01

    A biomedical beam line has been designed for the experimental area of a proton therapy facility to deliver mm to sub-mm size beams in the energy range of 20-50 MeV using the TRANSPORT/TURTLE beam optics codes and a newly-written program. The proton therapy facility is equipped with a 230 MeV fixed-energy cyclotron and an energy selection system based on a degrader and slits, so that beam currents available for therapy decrease at lower energies in the therapeutic beam energy range of 70-230 MeV. The new beam line system is composed of an energy-degrader, two slits, and three quadrupole magnets. The minimum beam sizes achievable at the focal point are estimated for the two energies of 50 and 20 MeV. The focused FWHM beam size is approximately 0.3 mm with an expected beam current of 20 pA when the beam energy is reduced to 50 MeV from 100 MeV, and roughly 0.8 mm with a current of 10 pA for a 20 MeV beam

  2. Deformable motion reconstruction for scanned proton beam therapy using on-line x-ray imaging

    NARCIS (Netherlands)

    Zhang, Ye; Knopf, A; Tanner, Colby; Boye, Dirk; Lomax, Antony J.

    2013-01-01

    Organ motion is a major problem for any dynamic radiotherapy delivery technique, and is particularly so for spot scanned proton therapy. On the other hand, the use of narrow, magnetically deflected proton pencil beams is potentially an ideal delivery technique for tracking tumour motion on-line. At

  3. Evolution of a beam dynamics model for the transport line in a proton therapy facility

    Science.gov (United States)

    Rizzoglio, V.; Adelmann, A.; Baumgarten, C.; Frey, M.; Gerbershagen, A.; Meer, D.; Schippers, J. M.

    2017-12-01

    During the conceptual design of an accelerator or beamline, first-order beam dynamics models are essential for studying beam properties. However, they can only produce approximate results. During commissioning, these approximate results are compared to measurements, which will rarely coincide if the model does not include the relevant physics. It is therefore essential that this linear model is extended to include higher-order effects. In this paper, the effects of particle-matter interaction have been included in the model of the transport lines in the proton therapy facility at the Paul Scherrer Institut (PSI) in Switzerland. The first-order models of these beamlines provide an approximated estimation of beam size, energy loss and transmission. To improve the performance of the facility, a more precise model was required and has been developed with opal (Object Oriented Parallel Accelerator Library), a multiparticle open source beam dynamics code. In opal, the Monte Carlo simulations of Coulomb scattering and energy loss are performed seamless with the particle tracking. Beside the linear optics, the influence of the passive elements (e.g., degrader, collimators, scattering foils, and air gaps) on the beam emittance and energy spread can be analyzed in the new model. This allows for a significantly improved precision in the prediction of beam transmission and beam properties. The accuracy of the opal model has been confirmed by numerous measurements.

  4. The GEANT4 toolkit capability in the hadron therapy field: simulation of a transport beam line

    International Nuclear Information System (INIS)

    Cirrone, G.A.P.; Cuttone, G.; Di Rosa, F.; Raffaele, L.; Russo, G.; Guatelli, S.; Pia, M.G.

    2006-01-01

    At Laboratori Nazionali del Sud of the Instituto Nazionale di Fisica Nucleare of Catania (Sicily, Italy), the first Italian hadron therapy facility named CATANA (Centro di AdroTerapia ed Applicazioni Nucleari Avanzate) has been realized. Inside CATANA 62 MeV proton beams, accelerated by a superconducting cyclotron, are used for the radiotherapeutic treatments of some types of ocular tumours. Therapy with hadron beams still represents a pioneer technique, and only a few centers worldwide can provide this advanced specialized cancer treatment. On the basis of the experience so far gained, and considering the future hadron-therapy facilities to be developed (Rinecker, Munich Germany, Heidelberg/GSI, Darmstadt, Germany, PSI Villigen, Switzerland, CNAO, Pavia, Italy, Centro di Adroterapia, Catania, Italy) we decided to develop a Monte Carlo application based on the GEANT4 toolkit, for the design, the realization and the optimization of a proton-therapy beam line. Another feature of our project is to provide a general tool able to study the interactions of hadrons with the human tissue and to test the analytical-based treatment planning systems actually used in the routine practice. All the typical elements of a hadron-therapy line, such as diffusers, range shifters, collimators and detectors were modelled. In particular, we simulated the Markus type ionization chamber and a Gaf Chromic film as dosimeters to reconstruct the depth (Bragg peak and Spread Out Bragg Peak) and lateral dose distributions, respectively. We validated our simulated detectors comparing the results with the experimental data available in our facility

  5. The GEANT4 toolkit capability in the hadron therapy field: simulation of a transport beam line

    Science.gov (United States)

    Cirrone, G. A. P.; Cuttone, G.; Di Rosa, F.; Raffaele, L.; Russo, G.; Guatelli, S.; Pia, M. G.

    2006-01-01

    At Laboratori Nazionali del Sud of the Instituto Nazionale di Fisica Nucleare of Catania (Sicily, Italy), the first Italian hadron therapy facility named CATANA (Centro di AdroTerapia ed Applicazioni Nucleari Avanzate) has been realized. Inside CATANA 62 MeV proton beams, accelerated by a superconducting cyclotron, are used for the radiotherapeutic treatments of some types of ocular tumours. Therapy with hadron beams still represents a pioneer technique, and only a few centers worldwide can provide this advanced specialized cancer treatment. On the basis of the experience so far gained, and considering the future hadron-therapy facilities to be developed (Rinecker, Munich Germany, Heidelberg/GSI, Darmstadt, Germany, PSI Villigen, Switzerland, CNAO, Pavia, Italy, Centro di Adroterapia, Catania, Italy) we decided to develop a Monte Carlo application based on the GEANT4 toolkit, for the design, the realization and the optimization of a proton-therapy beam line. Another feature of our project is to provide a general tool able to study the interactions of hadrons with the human tissue and to test the analytical-based treatment planning systems actually used in the routine practice. All the typical elements of a hadron-therapy line, such as diffusers, range shifters, collimators and detectors were modelled. In particular, we simulated the Markus type ionization chamber and a Gaf Chromic film as dosimeters to reconstruct the depth (Bragg peak and Spread Out Bragg Peak) and lateral dose distributions, respectively. We validated our simulated detectors comparing the results with the experimental data available in our facility.

  6. The GEANT4 toolkit capability in the hadron therapy field: simulation of a transport beam line

    Energy Technology Data Exchange (ETDEWEB)

    Cirrone, G.A.P. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, Catania (Italy); Cuttone, G. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, Catania (Italy); Di Rosa, F. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, Catania (Italy); Raffaele, L. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, Catania (Italy); Russo, G. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, Catania (Italy); Guatelli, S. [Istituto Nazionale di Fisica Nucleare, Sezione di Genova, Via Dodecaneso 33, Genova (Italy); Pia, M.G. [Istituto Nazionale di Fisica Nucleare, Sezione di Genova, Via Dodecaneso 33, Genova (Italy)

    2006-01-15

    At Laboratori Nazionali del Sud of the Instituto Nazionale di Fisica Nucleare of Catania (Sicily, Italy), the first Italian hadron therapy facility named CATANA (Centro di AdroTerapia ed Applicazioni Nucleari Avanzate) has been realized. Inside CATANA 62 MeV proton beams, accelerated by a superconducting cyclotron, are used for the radiotherapeutic treatments of some types of ocular tumours. Therapy with hadron beams still represents a pioneer technique, and only a few centers worldwide can provide this advanced specialized cancer treatment. On the basis of the experience so far gained, and considering the future hadron-therapy facilities to be developed (Rinecker, Munich Germany, Heidelberg/GSI, Darmstadt, Germany, PSI Villigen, Switzerland, CNAO, Pavia, Italy, Centro di Adroterapia, Catania, Italy) we decided to develop a Monte Carlo application based on the GEANT4 toolkit, for the design, the realization and the optimization of a proton-therapy beam line. Another feature of our project is to provide a general tool able to study the interactions of hadrons with the human tissue and to test the analytical-based treatment planning systems actually used in the routine practice. All the typical elements of a hadron-therapy line, such as diffusers, range shifters, collimators and detectors were modelled. In particular, we simulated the Markus type ionization chamber and a Gaf Chromic film as dosimeters to reconstruct the depth (Bragg peak and Spread Out Bragg Peak) and lateral dose distributions, respectively. We validated our simulated detectors comparing the results with the experimental data available in our facility.

  7. SCADA for microtron and beam transport line radio therapy machine subsystem

    International Nuclear Information System (INIS)

    Deshpande, Praveen; Palod, Shradha; Bhujle, Ashok

    2003-01-01

    Centre for Advanced Technology is developing a Radio Therapy Machine (RTM) to be used for cancer treatment. The radiotherapy machine has a Microtron consisting of a RF system, main and auxiliary magnets. It has a Beam transport line (BTL) consisting of fourteen magnets. This paper describes a PC based supervisory control and data acquisition system (SCADA) developed for controlling mainly the power supplies for the above sub systems from a remote location. It offers a graphic user interface (GUI) at the control room PC for RTM operation in engineering mode

  8. In-beam PET imaging for on-line adaptive proton therapy: an initial phantom study

    Science.gov (United States)

    Shao, Yiping; Sun, Xishan; Lou, Kai; Zhu, Xiaorong R.; Mirkovic, Dragon; Poenisch, Falk; Grosshans, David

    2014-07-01

    We developed and investigated a positron emission tomography (PET) system for use with on-line (both in-beam and intra-fraction) image-guided adaptive proton therapy applications. The PET has dual rotating depth-of-interaction measurable detector panels by using solid-state photomultiplier (SSPM) arrays and LYSO scintillators. It has a 44 mm diameter trans-axial and 30 mm axial field-of-view (FOV). A 38 mm diameter polymethyl methacrylate phantom was placed inside the FOV. Both PET and phantom axes were aligned with a collimated 179.2 MeV beam. Each beam delivered ˜50 spills (0.5 s spill and 1.5 s inter-spill time, 3.8 Gy at Bragg peak). Data from each beam were acquired with detectors at a given angle. Nine datasets for nine beams with detectors at nine different angles over 180° were acquired for full-tomographic imaging. Each dataset included data both during and 5 min after irradiations. The positron activity-range was measured from the PET image reconstructed from all nine datasets and compared to the results from simulated images. A 22Na disc-source was also imaged after each beam to monitor the PET system's performance. PET performed well except for slight shifts of energy photo-peak positions (<1%) after each beam, due mainly to the neutron exposure of SSPM that increased the dark-count noise. This minor effect was corrected offline with a shifting 350-650 keV energy window for each dataset. The results show a fast converging of activity-ranges measured by the prototype PET with high sensitivity and uniform resolution. Sub-mm activity-ranges were achieved with minimal 6 s acquisition time and three spill irradiations. These results indicate the feasibility of PET for intra-fraction beam-range verification. Further studies are needed to develop and apply a novel clinical PET system for on-line image-guided adaptive proton therapy.

  9. SLIA beam line design

    International Nuclear Information System (INIS)

    Petillo, J.; Chernin, D.; Kostas, C.; Mondelli, A.

    1990-01-01

    The Spiral Line Induction Accelerator (SLIA) is a multi-kiloampere compact electron accelerator. It uses linear induction accelerator modules on the straight sections of a racetrack spiral, with strong-focusing bends to recirculate the electrons. The strong focusing is provided by stellarator windings on the bends. Stellarator coils are used to provide the strong focusing on the bends. The matching of the electron beam from a diode through a series of accelerator modules and stellarator bends is a major issue in the design of this accelerator. The beam line design for a proof-of-concept SLIA experiment (10 kA, 7 MeV) to be carried out at Pulse Sciences, Inc. will be presented. The design will demonstrate beam matching from element to element in the focusing system, the design of an achromatic bend, and the requirements for avoiding collective instabilities

  10. Status of ACCULINNA beam line

    CERN Document Server

    Rodin, A M; Bogdanov, D D; Golovkov, M S; Fomichev, A S; Sidorchuk, S I; Slepnev, R S; Wolski, R; Ter-Akopian, G M; Oganessian, Yu T; Yukhimchuk, A A; Perevozchikov, V V; Vinogradov, Yu I; Grishenchkin, S K; Demin, A M; Zlatoustovskii, S V; Kuryakin, A V; Filchagin, S V; Ilkaev, R I

    2003-01-01

    The separator ACCULINNA was upgraded to achieve new experimental requirements. The beam line was extended by new ion-optical elements beyond the cyclotron hall. The new arrangements yield much better background conditions. The intensities of sup 6 He and sup 8 He radioactive beams produced in fragmentation of 35 A MeV sup 1 sup 1 B ions were increased up to a factor of 10. The upgraded beam line was used in experiments to study the sup 5 H resonance states populated in the t+t reaction. A cryogenic liquid tritium target was designed and installed at the separator beam line.

  11. Beam line design using G4BeamLine

    CERN Document Server

    Dogan, Arda

    2014-01-01

    In Turkey in Ankara TAEK SANAEM Proton Accelerator Facility (PAF), there is a cyclotron which produces a focused intense 30 MeV proton beam and sends this beam to four different arms, three of which uses this beam to produce pharmaceutical medicine. The remaining one is spared for R&D purposes and the idea was to use these protons coming out from the fourth arm to use space radiation tests, which cannot be done in Turkey at the moment. However, according to SCC 25100 standards which is for 30 MeV protons, the beam coming out of cyclotron is too intense and focused to use for space radiation tests. Therefore, the main aim of my project is to design a beam line which will defocus the beam and reduce the flux so that the space radiation tests can be done according to the standards of SCC 25100.

  12. Standardization of beam line representations

    International Nuclear Information System (INIS)

    Carey, David C.

    1998-01-01

    Standardization of beam line representations means that a single set of data can be used in many situations to represent a beam line. This set of data should be the same no matter what the program to be run or the calculation to be made. We have concerned ourselves with three types of standardization: (1) The same set of data should be usable by different programs. (2) The inclusion of other items in the data, such as calculations to be done, units to be used, or preliminary specifications, should be in a notation similar to the lattice specification. (3) A single set of data should be used to represent a given beam line, no matter what is being modified or calculated. The specifics of what is to be modified or calculated can be edited into the data as part of the calculation. These three requirements all have aspects not previously discussed in a public forum. Implementations into TRANSPORT will be discussed

  13. Standardization of beam line representations

    International Nuclear Information System (INIS)

    Carey, David C.

    1999-01-01

    Standardization of beam line representations means that a single set of data can be used in many situations to represent a beam line. This set of data should be the same no matter what the program to be run or the calculation to be made. We have concerned ourselves with three types of standardization: (1) The same set of data should be usable by different programs. (2) The inclusion of other items in the data, such as calculations to be done, units to be used, or preliminary specifications, should be in a notation similar to the lattice specification. (3) A single set of data should be used to represent a given beam line, no matter what is being modified or calculated. The specifics of what is to be modified or calculated can be edited into the data as part of the calculation. These three requirements all have aspects not previously discussed in a public forum. Implementations into TRANSPORT will be discussed

  14. Proton beam therapy facility

    International Nuclear Information System (INIS)

    1984-01-01

    It is proposed to build a regional outpatient medical clinic at the Fermi National Accelerator Laboratory (Fermilab), Batavia, Illinois, to exploit the unique therapeutic characteristics of high energy proton beams. The Fermilab location for a proton therapy facility (PTF) is being chosen for reasons ranging from lower total construction and operating costs and the availability of sophisticated technical support to a location with good access to patients from the Chicago area and from the entire nation. 9 refs., 4 figs., 26 tabs

  15. Proton beam therapy facility

    Energy Technology Data Exchange (ETDEWEB)

    1984-10-09

    It is proposed to build a regional outpatient medical clinic at the Fermi National Accelerator Laboratory (Fermilab), Batavia, Illinois, to exploit the unique therapeutic characteristics of high energy proton beams. The Fermilab location for a proton therapy facility (PTF) is being chosen for reasons ranging from lower total construction and operating costs and the availability of sophisticated technical support to a location with good access to patients from the Chicago area and from the entire nation. 9 refs., 4 figs., 26 tabs.

  16. Modification of beam lines at VEC

    Energy Technology Data Exchange (ETDEWEB)

    Shoor, Bivas; Chakraborty, P S; Mallik, C; Bhandari, R K [Variable Energy Cyclotron Centre, Calcutta (India)

    1997-12-01

    From the experience of light ion beam transportation through the Variable Energy Cyclotron beam line, it was observed that the beam line performance has to be improved in view of heavy ion acceleration program at the centre. The aim of this work was to study the feasibility of reducing the number of operational parameters without hampering the beam transmission and at the same time, to improve the vacuum of the beam line by reducing the hardware 2 refs., 1 fig.

  17. SU-E-J-92: On-Line Cone Beam CT Based Planning for Emergency and Palliative Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Held, M; Morin, O; Pouliot, J [UC San Francisco, San Francisco, CA (United States)

    2014-06-01

    Purpose: To evaluate and develop the feasibility of on-line cone beam CT based planning for emergency and palliative radiotherapy treatments. Methods: Subsequent to phantom studies, a case library of 28 clinical megavoltage cone beam CT (MVCBCT) was built to assess dose-planning accuracies on MVCBCT for all anatomical sites. A simple emergency treatment plan was created on the MVCBCT and copied to its reference CT. The agreement between the dose distributions of each image pair was evaluated by the mean dose difference of the dose volume and the gamma index of the central 2D axial plane. An array of popular urgent and palliative cases was also evaluated for imaging component clearance and field-of-view. Results: The treatment cases were categorized into four groups (head and neck, thorax/spine, pelvis and extremities). Dose distributions for head and neck treatments were predicted accurately in all cases with a gamma index of >95% for 2% and 2 mm criteria. Thoracic spine treatments had a gamma index as low as 60% indicating a need for better uniformity correction and tissue density calibration. Small anatomy changes between CT and MVCBCT could contribute to local errors. Pelvis and sacral spine treatment cases had a gamma index between 90% and 98% for 3%/3 mm criteria. The limited FOV became an issue for large pelvis patients. Imaging clearance was difficult for cases where the tumor was positioned far off midline. Conclusion: The MVCBCT based dose planning and delivery approach is feasible in many treatment cases. Dose distributions for head and neck patients are unrestrictedly predictable. Some FOV restrictions apply to other treatment sites. Lung tissue is most challenging for accurate dose calculations given the current imaging filters and corrections. Additional clinical cases for extremities need to be included in the study to assess the full range of site-specific planning accuracies. This work is supported by Siemens.

  18. A specialized bioengineering ion beam line

    International Nuclear Information System (INIS)

    Yu, L.D.; Sangyuenyongpipat, S.; Sriprom, C.; Thongleurm, C.; Suwanksum, R.; Tondee, N.; Prakrajang, K.; Vilaithong, T.; Brown, I.G.; Wiedemann, H.

    2007-01-01

    A specialized bioengineering ion beam line has recently been completed at Chiang Mai University to meet rapidly growing needs of research and application development in low-energy ion beam biotechnology. This beam line possesses special features: vertical main beam line, low-energy (30 keV) ion beams, double swerve of the beam, a fast pumped target chamber, and an in-situ atomic force microscope (AFM) system chamber. The whole beam line is situated in a bioclean environment, occupying two stories. The quality of the ion beam has been studied. It has proved that this beam line has significantly contributed to our research work on low-energy ion beam biotechnology

  19. The appearance of beam lines

    International Nuclear Information System (INIS)

    Carey, D.C.

    1993-05-01

    The combination of an existing graphics package with a large program like TRANSPORT has often resulted in considerable modification to the large program. Use of other graphics package has resulted in essentially having to repeat the work. This difficulty has been avoided in a modification of TRANSPORT which produce layouts of beam lines. Drawings of the reference trajectory and three-dimensional images of all magnets are made by the graphics package TOP DRAWER. Nothing specific to TOP DRAWER or any other graphics has been incorporated into TRANSPORT. If a user is with a different graphics package he or she can then begin usage of this alternate package essentially immediately

  20. Beam line design for a low energy electron beam

    International Nuclear Information System (INIS)

    Arvind Kumar; Mahadevan, S.

    2002-01-01

    The design of a beam line for transport of a 70 keV electron beam from a thermionic gun to the Plane Wave Transformer (PWT) linac incorporating two solenoid magnets, a beam profile monitor and drift sections is presented. We used beam dynamics codes EGUN, PARMELA and compare simulated results with analytical calculations. (author)

  1. Beam line to S155

    CERN Multimedia

    1977-01-01

    The experiment S155 was designed by the Orsay (CSNM-CNRS) Collaboration to observe the properties of exotic light nuclei. It was installed in the PS neutrino tunnel. The photo shows a mass spectrometer (in the background) on line with the PS proton beam which arrives (bottom, right) from the fast extraction FE74. Roger Fergeau stands on the left. The alkaline isotopes produced in the carbon-uranium target heated at 2000°C were swiftly extracted, mass separated, and brought to a detector behind the shielding. Sodium 34 (11 protons and 23 neutrons) was observed and its half-life of only 5 ms was measured. The excited levels 2+ of Magnesium 30 and Magnesium 32 (Sodium descendants) were localised, and the magic number 20 was found to vanish. Thus, the discovery made earlier for Sodium 30 and Sodium 32, with the same apparatus, was confirmed. (See also photo 7706511.)

  2. Electron beams in radiation therapy

    International Nuclear Information System (INIS)

    Bruinvis, I.A.D.

    1987-01-01

    Clinical electron beams in interaction with beam flattening and collimating devices are studied, in order to obtain the means for adequate electron therapy. A treatment planning method for arbitrary field shapes is developed that takes the properties of the collimated electron beams into account. An electron multiple-scattering model is extended to incorporate a model for the loss of electrons with depth, in order to improve electron beam dose planning. A study of ionisation measurements in two different phantom materials yields correction factors for electron beam dosimetry. (Auth.)

  3. Beam Optics for Typical Part of ISOL Beam Lines

    International Nuclear Information System (INIS)

    Jang, Ji Ho; Kwon, Hyeok Jung; Kim, Han Sung; Cho, Yong Sub

    2013-01-01

    KOMAC (Korea Multi-purpose Accelerator Complex) is doing a project, the detailed design of the ISOL beam lines for the heavy ion accelerator project of IBS (Institute of Basic Science) from August 2013 to February 2014. The heavy ion beams are transported by using the electrostatic quadrupoles and electrostatic benders between the equipment. The work-scope of the project is the beam optics design of the beam lines and the detailed design of the beam optics components, the electrostatic quadrupoles and the electrostatic bender. This work summarized the initial result of beam optics design of the beam line. We performed the beam optics simulation in two regions of ISOL beam lines and found that beam envelope is less than 2 cm. We will check that the poletip file values are reasonable or not in near future, and we also applied this method to the other parts of the ISOL beam line and optimize them. The result will be used the detailed design of the electrostatic quadrupoles and benders

  4. Vaccum and beam diagnostic controls for ORIC beam lines

    International Nuclear Information System (INIS)

    Tatum, B.A.

    1991-01-01

    Vacuum and beam diagnostic equipment on beam lines from the Oak Ridge Isochronous Cyclotron, ORIC, is now controlled by a new dedicated system. The new system is based on an industrial programmable logic controller with an IBM AT personal computer providing control room operator interface. Expansion of this system requires minimal reconfiguration and programming, thus facilitating the construction of additional beam lines. Details of the implementation, operation, and performance of the system are discussed. 2 refs., 2 figs

  5. A directly heated electron beam line source

    International Nuclear Information System (INIS)

    Iqbal, M.; Masood, K.; Rafiq, M.; Chaudhry, M.A.

    2002-05-01

    A 140-mm cathode length, Electron Beam Line Source with a high degree of focusing of the beam is constructed. The design principles and basic characteristic considerations for electron beam line source consists of parallel plate electrode geometric array as well as a beam power of 35kW are worked out. The dimensions of the beam at the work site are 1.25xl00mm. The gun is designed basically for the study of evaporation and deposition characteristic of refractory metals for laboratory use. However, it may be equally used for melting and casting of these metals. (author)

  6. Some aspects of VUV beam line design

    International Nuclear Information System (INIS)

    Gaupp, A.; Peatman, W.

    1997-01-01

    Some aspects of the design and usage of vacuum ultraviolet beam lines are discussed. Fermat's principle for imaging is introduced and applied to grating monochromators. Some typical vacuum ultraviolet beam lines are presented, and some further topics believed to be of importance today and in the future are mentioned. (author)

  7. The Development and Clinical Use of a Beam ON-LINE PET System Mounted on a Rotating Gantry Port in Proton Therapy

    International Nuclear Information System (INIS)

    Nishio, Teiji; Miyatake, Aya; Ogino, Takashi; Nakagawa, Keiichi; Saijo, Nagahiro; Esumi, Hiroyasu

    2010-01-01

    Purpose: To verify the usefulness of our developed beam ON-LINE positron emission tomography (PET) system mounted on a rotating gantry port (BOLPs-RGp) for dose-volume delivery-guided proton therapy (DGPT). Methods and Materials: In the proton treatment room at our facility, a BOLPs-RGp was constructed so that a planar PET apparatus could be mounted with its field of view covering the iso-center of the beam irradiation system. Activity measurements were performed in 48 patients with tumors of the head and neck, liver, lungs, prostate, and brain. The position and intensity of the activity were measured using the BOLPs-RGp during the 200 s immediately after the proton irradiation. Results: The daily measured activity images acquired by the BOLPs-RGp showed the proton irradiation volume in each patient. Changes in the proton-irradiated volume were indicated by differences between a reference activity image (taken at the first treatment) and the daily activity-images. In the case of head-and-neck treatment, the activity distribution changed in the areas where partial tumor reduction was observed. In the case of liver treatment, it was observed that the washout effect in necrotic tumor cells was slower than in non-necrotic tumor cells. Conclusions: The BOLPs-RGp was developed for the DGPT. The accuracy of proton treatment was evaluated by measuring changes of daily measured activity. Information about the positron-emitting nuclei generated during proton irradiation can be used as a basis for ensuring the high accuracy of irradiation in proton treatment.

  8. External Beam Therapy (EBT)

    Science.gov (United States)

    ... type your comment or suggestion into the following text box: Comment: E-mail: Area code: Phone no: ... Colorectal Cancer Treatment Head and Neck Cancer Treatment Intensity-Modulated Radiation Therapy (IMRT) Brain ...

  9. Correction for ‘artificial’ electron disequilibrium due to cone-beam CT density errors: implications for on-line adaptive stereotactic body radiation therapy of lung

    International Nuclear Information System (INIS)

    Disher, Brandon; Hajdok, George; Craig, Jeff; Gaede, Stewart; Battista, Jerry J; Wang, An

    2013-01-01

    Cone-beam computed tomography (CBCT) has rapidly become a clinically useful imaging modality for image-guided radiation therapy. Unfortunately, CBCT images of the thorax are susceptible to artefacts due to scattered photons, beam hardening, lag in data acquisition, and respiratory motion during a slow scan. These limitations cause dose errors when CBCT image data are used directly in dose computations for on-line, dose adaptive radiation therapy (DART). The purpose of this work is to assess the magnitude of errors in CBCT numbers (HU), and determine the resultant effects on derived tissue density and computed dose accuracy for stereotactic body radiation therapy (SBRT) of lung cancer. Planning CT (PCT) images of three lung patients were acquired using a Philips multi-slice helical CT simulator, while CBCT images were obtained with a Varian On-Board Imaging system. To account for erroneous CBCT data, three practical correction techniques were tested: (1) conversion of CBCT numbers to electron density using phantoms, (2) replacement of individual CBCT pixel values with bulk CT numbers, averaged from PCT images for tissue regions, and (3) limited replacement of CBCT lung pixels values (LCT) likely to produce artificial lateral electron disequilibrium. For each corrected CBCT data set, lung SBRT dose distributions were computed for a 6 MV volume modulated arc therapy (VMAT) technique within the Philips Pinnacle treatment planning system. The reference prescription dose was set such that 95% of the planning target volume (PTV) received at least 54 Gy (i.e. D95). Further, we used the relative depth dose factor as an a priori index to predict the effects of incorrect low tissue density on computed lung dose in regions of severe electron disequilibrium. CT number profiles from co-registered CBCT and PCT patient lung images revealed many reduced lung pixel values in CBCT data, with some pixels corresponding to vacuum (−1000 HU). Similarly, CBCT data in a plastic lung

  10. Neutron beams for therapy

    International Nuclear Information System (INIS)

    Kuplenikov, Eh.L.; Dovbnya, A.N.; Telegin, Yu.N.; Tsymbal, V.A.; Kandybej, S.S.

    2011-01-01

    It was given the analysis and generalization of the study results carried out during some decades in many world countries on application of thermal, epithermal and fast neutrons for neutron, gamma-neutron and neutron-capture therapy. The main attention is focused on the practical application possibility of the accumulated experience for the base creation for medical research and the cancer patients effective treatment.

  11. The IFUSP microtron accelerator beam transport line

    International Nuclear Information System (INIS)

    Rios, Paulo Beolchi

    2002-01-01

    In this work, the electron optical project of the IFUSP microtron beam transport line is presented, including the operational values for the parameters of the dipolar and quadrupolar electromagnets, as well as their location along the beam line. Analytical calculations and computer simulations were performed to obtain these results, and a programming tool was developed in order to analyze the beam parameters and to help studying racetrack microtrons. The electron optical simulations were split into two different study cases: the microtron booster, and the transfer line. In the first case, it was determined the main operational parameters of a microtron working far from its usual stability conditions. In the latter, it was done the basic design of the linking line between the booster and main (not yet built) microtrons, and between them and the experimental hall, with a total path length of approximately 32 m including large horizontal and vertical deflections with variable beam energy. (author)

  12. CONTINOUS EXTRACTED BEAM IN THE AGS FAST EXTERNAL BEAM LINE

    International Nuclear Information System (INIS)

    GLENN, J.W.; TSOUPAS, N.; BROWN, K.A.; BIRYUKOV, V.M.

    2001-01-01

    A method to split off a few percent of the 6 x 10 13 AGS beam delivered to the Slow External Beam (SEB) lines and send it down the Fast External Beam line (FEB) has been developed. The mission is to feed a counter experiment off the FEB that directly measures the neutrino mass using the muon storage ring. The use of normal thin septum splitters would have an excessive loss overhead and been optically difficult. The AGS Slow Extraction uses a third integer resonance with sextuple strength so the resonance width is a few percent of the beam width. This results in a low density tail which will be clipped by a bent crystal and deflected into the FEB channel. This clipping off of the tail should reduce losses in the SEB transport line. Details of modeled orbits, particle distribution and extraction trajectories into and out off the crystal will be given

  13. SU-C-202-03: A Tool for Automatic Calculation of Delivered Dose Variation for Off-Line Adaptive Therapy Using Cone Beam CT

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, B; Lee, S; Chen, S; Zhou, J; Prado, K; D’Souza, W; Yi, B [University of Maryland School of Medicine, Baltimore, MD (United States)

    2016-06-15

    Purpose: Monitoring the delivered dose is an important task for the adaptive radiotherapy (ART) and for determining time to re-plan. A software tool which enables automatic delivered dose calculation using cone-beam CT (CBCT) has been developed and tested. Methods: The tool consists of four components: a CBCT Colleting Module (CCM), a Plan Registration Moduel (PRM), a Dose Calculation Module (DCM), and an Evaluation and Action Module (EAM). The CCM is triggered periodically (e.g. every 1:00 AM) to search for newly acquired CBCTs of patients of interest and then export the DICOM files of the images and related registrations defined in ARIA followed by triggering the PRM. The PRM imports the DICOM images and registrations, links the CBCTs to the related treatment plan of the patient in the planning system (RayStation V4.5, RaySearch, Stockholm, Sweden). A pre-determined CT-to-density table is automatically generated for dose calculation. Current version of the DCM uses a rigid registration which regards the treatment isocenter of the CBCT to be the isocenter of the treatment plan. Then it starts the dose calculation automatically. The AEM evaluates the plan using pre-determined plan evaluation parameters: PTV dose-volume metrics and critical organ doses. The tool has been tested for 10 patients. Results: Automatic plans are generated and saved in the order of the treatment dates of the Adaptive Planning module of the RayStation planning system, without any manual intervention. Once the CTV dose deviates more than 3%, both email and page alerts are sent to the physician and the physicist of the patient so that one can look the case closely. Conclusion: The tool is capable to perform automatic dose tracking and to alert clinicians when an action is needed. It is clinically useful for off-line adaptive therapy to catch any gross error. Practical way of determining alarming level for OAR is under development.

  14. The elettra beam line control system

    International Nuclear Information System (INIS)

    Mignacco, M.; Abrami, A.; Dequal, Z.

    1994-01-01

    Elettra is a third generation Synchrotron Light Source located in Trieste (Italy). It consists of a full energy linac injector and a storage ring with beam energies between 1.5 and 2 GeV. The facility is scheduled to be operational by end 1993. For the whole project 22 beam lines from insertion devices are foreseen, each of them is composed of a large number of measurement and controls instruments, most of them embedded in intelligent devices; in addition each beam line can be considered unique compared to the others, having been designed to provide a different kind of synchrotron radiation. This results in a large not homogenous environment where more than 200,000 physical points have to be controlled. A joint team composed of Softeco Sismat and Digital Equipment has developed a fully automated beam line control system able to give full remote controls, with different kind of access rights, to beam line users and beam line specialists as well as a full integration with experiment control systems. ((orig.))

  15. Beam line for Schools: beyond expectations

    CERN Multimedia

    Cian O'Luanaigh

    2014-01-01

    Out of 292 proposals for CERN's first ever "Beam line for Schools" contest, two teams of high-school students – Odysseus' Comrades from Varvakios Pilot School in Athens, Greece and Dominicuscollege from Dominicus College in Nijmegen in the Netherlands – were selected to spend 10 days conducting their proposed experiments at the fully equipped T9 beam line on CERN's Meyrin site. Dedicated CERN staff and users from across the departments have put in a huge effort to ensure the success of the project.   Detector physicist Cenk Yidriz (centre, white helmet) explains the setup of the "Beamline for schools" experiment at the T9 beamline. It's finally beam time. After months of organisation, coding, engineering and even painting the experimental area, the T9 beam line is ready to deliver protons to experiments devised and built by high-school students. “They are here to collect data and experience the l...

  16. Diode line scanner for beam diagnostics

    International Nuclear Information System (INIS)

    Gustov, S.A.

    1987-01-01

    The device-scanning diode line is described. It is applied for beam profile measuring with space precision better than ± 0.5 mm and with discreteness of 3 mm along Y-axis and 0.25 mm along X-axis. The device is easy in construction, reliable and has a small time of information acquisition (2-5 min). The working range is from 100 to 10 6 rad/min (10 6 -10 10 part/mm 2 /s for 660 MeV protons). Radioresistance is 10 7 rad. The device can be applied for precise beam line element tuning at beam transporting and emittance measuring. The fixed diode line (a simplified device version) has smaller dimensions and smaller time of data acquisition (2-5 s). It is applied for quick preliminary beamline tuning. The flowsheet and different variants of data representation on beam profile are given

  17. Design of the ESCAR injection beam line

    International Nuclear Information System (INIS)

    Tanabe, J.; Staples, J.; Yourd, R.

    1975-01-01

    The design features of the elements of the ESCAR (Experimental Superconducting Accelerator Ring) injection beam line are described. The junction of the proton transport system with the ESCAR injection straight section requires the design of mechanical elements compatible with the 10 -11 torr vacuum requirements of the main ring. These elements include a novel septum magnet whose salient design features include a current-carrying septum of tapered thicknesses to reduce the overall power requirements and total enclosure of the magnet coil in a metal can for vacuum compatibility. Other elements are a wire electro-static septum and several fast-rise ''bump magnets''. A transition cryopump is designed to separate the main ring vacuum from the relatively poor 10 -6 torr vacuum of the conventional beam transport line. A brief description of the conventional beam transport line from the 50 MeV proton linac, recently installed for Bevatron injection,is also included. (U.S.)

  18. The clinical case for proton beam therapy

    Directory of Open Access Journals (Sweden)

    Foote Robert L

    2012-10-01

    Full Text Available Abstract Over the past 20 years, several proton beam treatment programs have been implemented throughout the United States. Increasingly, the number of new programs under development is growing. Proton beam therapy has the potential for improving tumor control and survival through dose escalation. It also has potential for reducing harm to normal organs through dose reduction. However, proton beam therapy is more costly than conventional x-ray therapy. This increased cost may be offset by improved function, improved quality of life, and reduced costs related to treating the late effects of therapy. Clinical research opportunities are abundant to determine which patients will gain the most benefit from proton beam therapy. We review the clinical case for proton beam therapy. Summary sentence Proton beam therapy is a technically advanced and promising form of radiation therapy.

  19. The clinical case for proton beam therapy

    International Nuclear Information System (INIS)

    Foote, Robert L; Haddock, Michael G; Yan, Elizabeth; Laack, Nadia N; Arndt, Carola A S

    2012-01-01

    Over the past 20 years, several proton beam treatment programs have been implemented throughout the United States. Increasingly, the number of new programs under development is growing. Proton beam therapy has the potential for improving tumor control and survival through dose escalation. It also has potential for reducing harm to normal organs through dose reduction. However, proton beam therapy is more costly than conventional x-ray therapy. This increased cost may be offset by improved function, improved quality of life, and reduced costs related to treating the late effects of therapy. Clinical research opportunities are abundant to determine which patients will gain the most benefit from proton beam therapy. We review the clinical case for proton beam therapy. Proton beam therapy is a technically advanced and promising form of radiation therapy

  20. Doppler-shifted neutral beam line shape and beam transmission

    International Nuclear Information System (INIS)

    Kamperschroer, J.H.; Grisham, L.R.; Kokatnur, N.; Lagin, L.J.; Newman, R.A.; O'Connor, T.E.; Stevenson, T.N.; von Halle, A.

    1994-04-01

    Analysis of Doppler-shifted Balmer-α line emission from the TFTR neutral beam injection systems has revealed that the line shape is well approximated by the sum of two Gaussians, or, alternatively, by a Lorentzian. For the sum of two Gaussians, the broad portion of the distribution contains 40% of the beam power and has a divergence five times that of the narrow part. Assuming a narrow 1/e- divergence of 1.3 degrees (based on fits to the beam shape on the calorimeter), the broad part has a divergence of 6.9 degrees. The entire line shape is also well approximated by a Lorentzian with a half-maximum divergence of 0.9 degrees. Up to now, fusion neutral beam modelers have assumed a single Gaussian velocity distribution, at the extraction plane, in each direction perpendicular to beam propagation. This predicts a beam transmission efficiency from the ion source to the calorimeter of 97%. Waterflow calorimetry data, however, yield a transmission efficiency of ∼75%, a value in rough agreement with predictions of the Gaussian or Lorentzian models presented here. The broad wing of the two Gaussian distribution also accurately predicts the loss in the neutralizer. An average angle of incidence for beam loss at the exit of the neutralizer is 2.2 degrees, rather than the 4.95 degrees subtended by the center of the ion source. This average angle of incidence, which is used in computing power densities on collimators, is shown to be a function of beam divergence

  1. Radiation therapy apparatus having retractable beam stopper

    International Nuclear Information System (INIS)

    Coad, G.L.

    1983-01-01

    This invention relates to a radiation therapy apparatus which utilized a linear translation mechanism for positioning a beam stopper. An apparatus is described wherein the beam stopper is pivotally attached to the therapy machine with an associated drive motor in such a way that the beam stopper retracts linearly

  2. Proton beam therapy control system

    Science.gov (United States)

    Baumann, Michael A [Riverside, CA; Beloussov, Alexandre V [Bernardino, CA; Bakir, Julide [Alta Loma, CA; Armon, Deganit [Redlands, CA; Olsen, Howard B [Colton, CA; Salem, Dana [Riverside, CA

    2008-07-08

    A tiered communications architecture for managing network traffic in a distributed system. Communication between client or control computers and a plurality of hardware devices is administered by agent and monitor devices whose activities are coordinated to reduce the number of open channels or sockets. The communications architecture also improves the transparency and scalability of the distributed system by reducing network mapping dependence. The architecture is desirably implemented in a proton beam therapy system to provide flexible security policies which improve patent safety and facilitate system maintenance and development.

  3. Beam line from straight-section 16

    CERN Multimedia

    CERN PhotoLab

    1971-01-01

    The start of a long trail. The beam line from straight-section 16, where protons are fast ejected, is seen at the point where it crosses the Linac shielding wall as it leaves the PS en route to the ISR.

  4. New wiggler beam line for SSRL

    International Nuclear Information System (INIS)

    Hoyer, E.

    1982-08-01

    A new high-intensity-beam line with a wiggler magnet source is described. This project, in final stages of design, is a joint effort between Lawrence Berkeley Laboratory (LBL), the Exxon Research and Engineering Company (EXXON), and the Stanford Synchrotron Radiation Laboratory (SSRL). Installation at SSRL will begin in the summer of 1982. The goal of this project is to provide extremely high-brightness synchrotron radiation beams over a broad spectral range from 50 eV to 40 keV. The radiation source is a 27 period (i.e., 55 pole) permanent magnet wiggler of a new design. The wiggler utilizes rare-earth cobalt (REC) material in the steel hybrid configuration to achieve high magnetic fields with short periods. An analysis has been made of the polarization, angular distribution and power density of the radiation produced by the wiggler. Details of the wiggler design are presented. The magnet is outside a thin walled (1mm) variable gap stainless steel vacuum chamber. The chamber gap will be opened to 1.8 cm for beam injection into SPEAR and then closed to 1.0 cm (or less) for operation. Five remotely controlled drives are provided; to change the wiggler gap, to change the vacuum chamber aperture and to position the wiggler. Details of the beam line optics and end stations are presented. Thermal loading on beam line components is severe. The peak power density at 7.5 m is 5 kW/cm 2 for the nominal wiggler field and present SPEAR beam currents and will approach 20 kW/cm 2 with the maximum wiggler field and projected SPEAR beam currents

  5. Thermal problems on high flux beam lines

    International Nuclear Information System (INIS)

    Avery, R.T.

    1983-09-01

    Wiggler and undulator magnets can provide very intense photon flux densities to beam line components. This paper addresses some thermal/materials consequences due to such impingement. The LBL/Exxon/SSRL hybrid-wiggler Beam Line VI now nearing operation will be able to provide up to approx. 7 kW of total photon power at planned SPEAR operating conditions. The first masks are located at 6.5 meters from the source and may receive a peak power density (transverse to the beam) exceeding 20 kW/cm 2 . Significantly, this heat transfer rate exceeds that radiated from the sun's surface (7 kW/cm 2 ) and is comparable to that of welding torches. Clearing, cooling and configuration are of critical importance. Configurations for the first fixed mask, the movable mask, and the pivot mask on this beam line are presented together with considerations of thermal stress fatigue and of heat transfer by conduction to water-cooling circuits. Some preliminary information on heating of crystals and mirrors is also presented

  6. Beam dynamics calculations for the linac booster beam line

    International Nuclear Information System (INIS)

    Lu, J.Q.; Cramer, J.G.; Storm, D.W.

    1987-01-01

    Beam optics focusing characteristics both in the transverse and longitudinal directions of the superconducting linac booster beam line are calculated for different particles. Three computer programs, which are TRANSPORT, LYRA and ENTIME, are used to simulate particle motions. The first one is used to simulate the particle radial motions. The effects of energy increase on to the transverse phase space area are considered by putting in accelerating matrices of each resonators. The second program is used to simulate particle longitudinal motions. Beam longitudinal motions are calculated with program ENTIME also, with which visual pictures in the Energy-Time phase space can be displayed on the terminal screen. Besides, the stability of the particle periodic motions in the radial directions are considered and calculated

  7. External Beam Radiation Therapy for Cancer

    Science.gov (United States)

    External beam radiation therapy is used to treat many types of cancer. it is a local treatment, where a machine aims radiation at your cancer. Learn more about different types of external beam radiation therapy, and what to expect if you're receiving treatment.

  8. On a laser beam fiducial line application for metrological purposes

    International Nuclear Information System (INIS)

    Batusov, V.; Budagov, J.; Lyablin, M.; Rusakovich, N.; Sisakyan, A.; Topilin, N.; Khubua, J.; Lasseur, C.

    2008-01-01

    The possibility of a collimated one-mode laser beam used as a fiducial line is considered. The technology of an 'extended' laser beam formation and application for a much extended fiducial line is proposed

  9. On- and off-line monitoring of ion beam treatment

    Energy Technology Data Exchange (ETDEWEB)

    Parodi, Katia, E-mail: katia.parodi@lmu.de

    2016-02-11

    Ion beam therapy is an emerging modality for high precision radiation treatment of cancer. In comparison to conventional radiation sources (photons, electrons), ion beams feature major dosimetric advantages due to their finite range with a localized dose deposition maximum, the Bragg peak, which can be selectively adjusted in depth. However, due to several sources of treatment uncertainties, full exploitation of these dosimetric advantages in clinical practice would require the possibility to visualize the stopping position of the ions in vivo, ideally in real-time. To this aim, different imaging methods have been proposed and investigated, either pre-clinically or even clinically, based on the detection of prompt or delayed radiation following nuclear interaction of the beam with the irradiated tissue. However, the chosen or ad-hoc developed instrumentation has often relied on technologies originally conceived for different applications, thus compromising on the achievable performances for the sake of cost-effectiveness. This contribution will review major examples of used instrumentation and related performances, identifying the most promising detector developments for next generation devices especially dedicated to on-line monitoring of ion beam treatment. Moreover, it will propose an original combination of different techniques in a hybrid detection scheme, aiming to make the most of complementary imaging methods and open new perspectives of image guidance for improved precision of ion beam therapy.

  10. 750 keV beam line construction at the KEK

    International Nuclear Information System (INIS)

    Ishimaru, H.; Anami, S.; Inagaki, T.; Sakaue, T.; Itoh, K.; Fukumoto, S.

    1976-01-01

    The construction of 750 keV beam line of the KEK injector of the 12 GeV proton synchrotron was described. The beam line consists of the beam focusing quadrupoles, vacuum system, the electrostatic chopper and the various beam monitors. (author)

  11. Implementation of EPICS based Control System for Radioisotope Beam line

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae-Ha; Ahn, Tae-Sung; Song, Young-Gi; Kwon, Hyeok-Jung; Cho, Yong-Sub [Korea Atomic Energy Research Institute, Gyeongju (Korea, Republic of)

    2015-10-15

    Korea Mult-purpose Accelerator Complex (KOMAC) has been operating 100 MeV proton linear accelerator . For operating 100 MeV linac, various control system has been implemented such as vacuum, power supply, RCCS and etc. KOMAC is operating two beam lines so that clients can use 100 MeV proton beam for their experiment. KOMAC sends beam to beam line and target room using two dipole magnets and several quadrupole magnets. As demand for experiments and Radius Isotope using beam is increased, another beam line is under construction and RI beam line control system is need. To synchronize with KOMAC control system, RI beam line control system is based on Experimental Physics and Industrial control System (EPICS) software. The beam is transported to RI beam line to control magnet power supply and vacuum. Implementation of RI beam line control system is presented and some preliminary results are reported. The base RI beam line control system is implemented. It can control beam direction and vacuum. Comparing archived data and current data, RI beam line and control system will be improved. In the future, scroll pump and gate control system will be implemented using programmable logic controller PLC. RI beam interlock sequence will be added to KOMAC interlock system to protect linac.

  12. High spin isomer beam line at RIKEN

    Energy Technology Data Exchange (ETDEWEB)

    Kishida, T.; Ideguchi, E.; Wu, H.Y. [Institute of Physical and Chemical Research, Saitama (Japan)] [and others

    1996-12-31

    Nuclear high spin states have been the subject of extensive experimental and theoretical studies. For the production of high spin states, fusion reactions are usually used. The orbital angular momentum brought in the reaction is changed into the nuclear spin of the compound nucleus. However, the maximum induced angular momentum is limited in this mechanism by the maximum impact parameter of the fusion reaction and by the competition with fission reactions. It is, therefore, difficult to populate very high spin states, and as a result, large {gamma}-detector arrays have been developed in order to detect subtle signals from such very high spin states. The use of high spin isomers in the fusion reactions can break this limitation because the high spin isomers have their intrinsic angular momentum, which can bring the additional angular momentum without increasing the excitation energy. There are two methods to use the high spin isomers for secondary reactions: the use of the high spin isomers as a target and that as a beam. A high spin isomer target has already been developed and used for several experiments. But this method has an inevitable shortcoming that only {open_quotes}long-lived{close_quotes} isomers can be used for a target: {sup 178}Hf{sup m2} (16{sup +}) with a half-life of 31 years in the present case. By developing a high spin isomer beam, the authors can utilize various short-lived isomers with a short half-life around 1 {mu}s. The high spin isomer beam line of RIKEN Accelerator Facility is a unique apparatus in the world which provides a high spin isomer as a secondary beam. The combination of fusion-evaporation reaction and inverse kinematics are used to produce high spin isomer beams; in particular, the adoption of `inverse kinematics` is essential to use short-lived isomers as a beam.

  13. Synthesis of Beam Lines with Necessary Properties

    CERN Document Server

    Andrianov, Serge

    2005-01-01

    In this paper a new approach to the problem of synthesis of beam lines is discussed. Usually this problem can be overcome by the use of numerical simulation and optimal control theory methods. But this results in sufficiently great number of variable parameters and functions. Obviously, that this degrades quality of a modeling procedure. The suggested approach is demonstrated on a problem of a microprobe design problem. Essence of the problem is that necessary to design a high precision focusing system which satisfies some additional conditions. For solution of this problem we use an algebraic treatment based on Lie algebraic methods and computer algebra techniques. Using the symmetry ideology this approach allows rewriting beam properties to enough simple conditions for control parameters and functions. This leads a set of desired solutions and show results in some most suitable form. Moreover, this approach decreases the number of variable parameters.

  14. The Imaging and Medical Beam Line at the Australian Synchrotron

    Science.gov (United States)

    Hausermann, Daniel; Hall, Chris; Maksimenko, Anton; Campbell, Colin

    2010-07-01

    As a result of the enthusiastic support from the Australian biomedical, medical and clinical communities, the Australian Synchrotron is constructing a world-class facility for medical research, the `Imaging and Medical Beamline'. The IMBL began phased commissioning in late 2008 and is scheduled to commence the first clinical research programs with patients in 2011. It will provide unrivalled x-ray facilities for imaging and radiotherapy for a wide range of research applications in diseases, treatments and understanding of physiological processes. The main clinical research drivers are currently high resolution and sensitivity cardiac and breast imaging, cell tracking applied to regenerative and stem cell medicine and cancer therapies. The beam line has a maximum source to sample distance of 136 m and will deliver a 60 cm by 4 cm x-ray beam1—monochromatic and white—to a three storey satellite building fully equipped for pre-clinical and clinical research. Currently operating with a 1.4 Tesla multi-pole wiggler, it will upgrade to a 4.2 Tesla device which requires the ability to handle up to 21 kW of x-ray power at any point along the beam line. The applications envisaged for this facility include imaging thick objects encompassing materials, humans and animals. Imaging can be performed in the range 15-150 keV. Radiotherapy research typically requires energies between 30 and 120 keV, for both monochromatic and broad beam.

  15. Characterization of the Goubau line for testing beam diagnostic instruments

    Science.gov (United States)

    Kim, S. Y.; Stulle, F.; Sung, C. K.; Yoo, K. H.; Seok, J.; Moon, K. J.; Choi, C. U.; Chung, Y.; Kim, G.; Woo, H. J.; Kwon, J.; Lee, I. G.; Choi, E. M.; Chung, M.

    2017-12-01

    One of the main characteristics of the Goubau line is that it supports a low-loss, non-radiated surface wave guided by a dielectric-coated metal wire. The dominant mode of the surface wave along the Goubau line is a TM01 mode, which resembles the pattern of the electromagnetic fields induced in the metallic beam pipe when the charged particle beam passes through it. Therefore, the Goubau line can be used for the preliminary bench test and performance optimization of the beam diagnostic instruments without requiring charged particle beams from the accelerators. In this paper, we discuss the basic properties of the Goubau line for testing beam diagnostic instruments and present the initial test results for button-type beam position monitors (BPMs). The experimental results are consistent with the theoretical estimations, which indicates that Goubau line allows effective testing of beam diagnostic equipment.

  16. Design process and modeling studies of SSRL beam line wunder

    International Nuclear Information System (INIS)

    Bachrach, R.Z.; Bringans, R.D.

    1984-01-01

    SSRL Beam Line Wunder will be the first soft X-ray energy range synchrotron radiation beam line specifically designed to exploit the unique aspects of periodic insertion devices in the wiggler-undulator (wunder) regime. Aspects of the development of this beam line are described in this paper and in particular, we discuss the design methodology adopted and emphasize the joint optical, thermal and mechanical optimization studies that were required. (orig.)

  17. Magnet power supply and beam line control for a secondary beam line K6

    International Nuclear Information System (INIS)

    Suzuki, Y.; Takasaki, M.; Minakawa, M.; Ishii, H.; Kato, Y.; Ieiri, M.; Tanaka, K.H.; Noumi, H.; Yamanoi, Y.

    1992-01-01

    K6 is a secondary separated-beam line with momentum range up to 2.0 GeV/c in the north experimental hall at the KEK 12 GeV Proton Synchrotron (KEK-PS). On the construction, newly developed magnet power supplies (MPSs), in each of them a microprocessor is embedded, are introduced. The features of the MPS are as follows: 1, The MPS is connected to an upper-level beam line controller (BLC) by GPIB highway for exchanging simple messages. 2, All the operations of the MPS are supervised by the microprocessor, which has its individual parameters and fault messages. It reduces the load of the upper-level controller. 3, The MPS has functions to inspect itself and to report the result. It saves much time and labor of maintenance. (author)

  18. BEAM LINE DESIGN FOR THE CERN HIRADMAT TEST FACILITY

    CERN Document Server

    Hessler, C; Goddard, B; Meddahi, M; Weterings, W

    2009-01-01

    The LHC phase II collimation project requires beam shock and impact tests of materials used for beam intercepting devices. Similar tests are also of great interest for other accelerator components such as beam entrance/exit windows and protection devices. For this purpose a dedicated High Radiation Material test facility (HiRadMat) is under study. This facility may be installed at CERN at the location of a former beam line. This paper describes the associated beam line which is foreseen to deliver a 450 GeV proton beam from the SPS with an intensity of up to 3×1013 protons per shot. Different beam line designs will be compared and the choice of the beam steering and diagnostic elements will be discussed, as well as operational issues.

  19. Beam Line Design for the CERN Hiradmat Test Facility

    CERN Document Server

    Hessler, C; Goddard, B; Meddahi, M; Weterings, W

    2010-01-01

    The LHC phase II collimation project requires beam shock and impact tests of materials used for beam intercepting devices. Similar tests are also of great interest for other accelerator components such as beam entrance/exit windows and protection devices. For this purpose a dedicated High Radiation Material test facility (HiRadMat) is under study. This facility may be installed at CERN at the location of a former beam line. This paper describes the associated beam line which is foreseen to deliver a 450 GeV proton beam from the SPS with an intensity of up to 3×10**13 protons per shot. Different beam line designs will be compared and the choice of the beam steering and diagnostic elements will be discussed, as well as operational issues.

  20. A pencil beam algorithm for helium ion beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Fuchs, Hermann; Stroebele, Julia; Schreiner, Thomas; Hirtl, Albert; Georg, Dietmar [Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, 1090 Vienna (Austria); Department of Radiation Oncology, Medical University of Vienna/AKH Vienna, 1090 Vienna (Austria) and Comprehensive Cancer Center, Medical University of Vienna/AKH Vienna, 1090 Vienna (Austria); Department of Radiation Oncology, Medical University of Vienna/AKH Vienna (Austria) and Comprehensive Cancer Center, Medical University of Vienna/AKH Vienna, 1090 Vienna (Austria); PEG MedAustron, 2700 Wiener Neustadt (Austria); Department of Nuclear Medicine, Medical University of Vienna, 1090 Vienna (Austria); Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, 1090 Vienna (Austria); Department of Radiation Oncology, Medical University of Vienna/AKH Vienna, 1090 Vienna (Austria) and Comprehensive Cancer Center, Medical University of Vienna/AKH Vienna, 1090 Vienna (Austria)

    2012-11-15

    Purpose: To develop a flexible pencil beam algorithm for helium ion beam therapy. Dose distributions were calculated using the newly developed pencil beam algorithm and validated using Monte Carlo (MC) methods. Methods: The algorithm was based on the established theory of fluence weighted elemental pencil beam (PB) kernels. Using a new real-time splitting approach, a minimization routine selects the optimal shape for each sub-beam. Dose depositions along the beam path were determined using a look-up table (LUT). Data for LUT generation were derived from MC simulations in water using GATE 6.1. For materials other than water, dose depositions were calculated by the algorithm using water-equivalent depth scaling. Lateral beam spreading caused by multiple scattering has been accounted for by implementing a non-local scattering formula developed by Gottschalk. A new nuclear correction was modelled using a Voigt function and implemented by a LUT approach. Validation simulations have been performed using a phantom filled with homogeneous materials or heterogeneous slabs of up to 3 cm. The beams were incident perpendicular to the phantoms surface with initial particle energies ranging from 50 to 250 MeV/A with a total number of 10{sup 7} ions per beam. For comparison a special evaluation software was developed calculating the gamma indices for dose distributions. Results: In homogeneous phantoms, maximum range deviations between PB and MC of less than 1.1% and differences in the width of the distal energy falloff of the Bragg-Peak from 80% to 20% of less than 0.1 mm were found. Heterogeneous phantoms using layered slabs satisfied a {gamma}-index criterion of 2%/2mm of the local value except for some single voxels. For more complex phantoms using laterally arranged bone-air slabs, the {gamma}-index criterion was exceeded in some areas giving a maximum {gamma}-index of 1.75 and 4.9% of the voxels showed {gamma}-index values larger than one. The calculation precision of the

  1. Second-Line Therapy for Advanced NSCLC.

    Science.gov (United States)

    Weiss, Jared M; Stinchcombe, Thomas E

    2013-01-01

    Most patients with lung cancer have non-small cell lung cancer (NSCLC) subtype and have advanced disease at the time of diagnosis. Improvements in both first-line and subsequent therapies are allowing longer survival and enhanced quality of life for these patients. The median overall survival observed in many second-line trials is approximately 9 months, and many patients receive further therapy after second-line therapy. The cytotoxic agents pemetrexed and docetaxel and the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) erlotinib and gefitinib are standard second-line therapies. For patients with EGFR mutation, a TKI is the favored second-line therapy if not already used in first-line therapy. For patients without the EGFR mutation, TKIs are an option, but many oncologists favor cytotoxic therapy. The inhibitor of the EML4/ALK fusion protein, crizotinib, has recently become a standard second-line treatment for patients with the gene rearrangement and has promise for patients with the ROS1 rearrangement.

  2. Fan beam intensity modulated proton therapy

    Science.gov (United States)

    Hill, Patrick M.

    A fan beam proton therapy is developed which delivers intensity modulated proton therapy using distal edge tracking. The system may be retrofit onto existing proton therapy gantries without alterations to infrastructure in order to improve treatments through intensity modulation. A novel range and intensity modulation system is designed using acrylic leaves that are inserted or retracted from subsections of the fan beam. Leaf thicknesses are chosen in a base-2 system and motivated in a binary manner. Dose spots from individual beam channels range between 1 and 5 cm. Integrated collimators attempting to limit crosstalk among beam channels are investigated, but found to be inferior to uncollimated beam channel modulators. A treatment planning system performing data manipulation in MATLAB and dose calculation in MCNPX is developed. Beamlet dose is calculated on patient CT data and a fan beam source is manually defined to produce accurate results. An energy deposition tally follows the CT grid, allowing straightforward registration of dose and image data. Simulations of beam channels assume that a beam channel either delivers dose to a distal edge spot or is intensity modulated. A final calculation is performed separately to determine the deliverable dose accounting for all sources of scatter. Treatment plans investigate the effects that varying system parameters have on dose distributions. Beam channel apertures may be as large as 20 mm because the sharp distal falloff characteristic of proton dose provides sufficient intensity modulation to meet dose objectives, even in the presence of coarse lateral resolution. Dose conformity suffers only when treatments are delivered from less than 10 angles. Jaw widths of 1--2 cm produce comparable dose distributions, but a jaw width of 4 cm produces unacceptable target coverage when maintaining critical structure avoidance. Treatment time for a prostate delivery is estimated to be on the order of 10 minutes. Neutron production

  3. Review of electron beam therapy physics

    International Nuclear Information System (INIS)

    Hogstrom, Kenneth R; Almond, Peter R

    2006-01-01

    For over 50 years, electron beams have been an important modality for providing an accurate dose of radiation to superficial cancers and disease and for limiting the dose to underlying normal tissues and structures. This review looks at many of the important contributions of physics and dosimetry to the development and utilization of electron beam therapy, including electron treatment machines, dose specification and calibration, dose measurement, electron transport calculations, treatment and treatment-planning tools, and clinical utilization, including special procedures. Also, future changes in the practice of electron therapy resulting from challenges to its utilization and from potential future technology are discussed. (review)

  4. Initial Beam Test of the Prototype Strip Line BPM

    International Nuclear Information System (INIS)

    Kwon, Hyeok Jung; Kim, Han Sung; Seol, Kyung Tae; Ryu, Jin Yeong; Jang, Ji Ho; Cho, Yong Sub

    2011-01-01

    A beam position monitor (BPM) was developed which would be used for the Proton Engineering Frontier Project (PEFP) beam line. It is a strip line BPM which is commonly used one for the proton beam. The BPM cross section was designed with the SUPERFISH code and the matching section to the feed through was designed by the MWS code. The design parameters of the BPM are shown in Table 1. The designed BPM was fabricated to verify the manufacturing process and check its electrical performance. After the low power test at the test stand, the BPM was installed at the 20-MeV proton accelerator beam line as shown in Fig. 1

  5. Beam instrumentation for the BNL Heavy Ion Transfer Line

    International Nuclear Information System (INIS)

    Witkover, R.L.; Buxton, W.; Castillo, V.; Feigenbaum, I.; Lazos, A.; Li, Z.G.; Smith, G.; Stoehr, R.

    1987-01-01

    The Heavy Ion Transfer Line (HITL) was constructed to transport beams from the BNL Tandem Van de Graaff (TVDG) to be injected into the AGS. Because the beam line is approximately 2000 feet long and the particle rigidity is so low, 20 beam monitor boxes were placed along the line. The intensity ranges from 1 to 100 nanoAmps for the dc trace beam used for line set-up, to over 100 μA for the pulsed beam to be injected into the AGS. Profiles are measured using multiwire arrays (HARPS) while Faraday cups and beam transformers monitor the intensity. The electronics stations are operated through 3 Instrumentation Controllers networked to Apollo workstations in the TVDG and AGS control rooms. Details of the detectors and electronics designs and performance will be given

  6. Commissioning of the LHC Beam Transfer Line TI 8

    International Nuclear Information System (INIS)

    Uythoven, J.A.; Arduini, G.; Goddard, B.; Jacquet, D.; Kain, V.; Lamont, M.; Mertens, V.; Spinks, A.; Wenninger, J.; Chao, Y.-C.

    2005-01-01

    The first of the two LHC transfer lines was commissioned in autumn 2004. Beam reached an absorber block located some 2.5 km downstream of the SPS extraction point at the first shot, without the need of any threading. The hardware preparation and commissioning phase will be summarized, followed by a description of the beam tests and their results regarding optics and other line parameters, including the experience gained with beam instrumentation, the control system and the machine protection equipment

  7. Simulation of a low energy beam transport line

    International Nuclear Information System (INIS)

    Yang Yao; Liu Zhanwen; Zhang Wenhui; Ma Hongyi; Zhang Xuezhen; Zhao Hongwei; Yao Ze'en

    2012-01-01

    A 2.45 GHz electron cyclotron resonance intense proton source and a low energy beam transport line with dual-Glaser lens were designed and fabricated by Institute of Modern Physics for a compact pulsed hadron source at Tsinghua. The intense proton beams extracted from the ion source are transported through the transport line to match the downstream radio frequency quadrupole accelerator. Particle-in-cell code BEAMPATH was used to carry out the beam transport simulations and optimize the magnetic field structures of the transport line. Emittance growth due to space charge and spherical aberrations of the Glaser lens were studied in both theory and simulation. The results show that narrow beam has smaller aberrations and better beam quality through the transport line. To better match the radio frequency quadrupole accelerator, a shorter transport line is desired with sufficient space charge neutralization. (authors)

  8. Beam diagnostics and data acquisition system for ion beam transport line used in applied research

    International Nuclear Information System (INIS)

    Skuratov, V.A.; Didyk, A.Yu.; Arkhipov, A.V.; Illes, A.; Bodnar, K.; Illes, Z.; Havancsak, K.

    1999-01-01

    Ion beam transport line for applied research on U-400 cyclotron, beam diagnostics and data acquisition system for condensed matter studies are described. The main features of Windows-based real time program are considered

  9. Evaluation of beam-line components for use in a large neutral-beam injector

    International Nuclear Information System (INIS)

    Fink, J.H.

    1977-01-01

    A conceptual model of a neutral-beam injector was used to examine the effect of beam-line components on reactor performance. Criteria were established to optimize a reactor's reliability and minimize its cost

  10. Principles and practice of proton beam therapy

    CERN Document Server

    Das, Indra J

    2015-01-01

    Commissioned by The American Association of Physicists in Medicine (AAPM) for their June 2015 Summer School, this is the first AAPM monograph printed in full color. Proton therapy has been used in radiation therapy for over 70 years, but within the last decade its use in clinics has grown exponentially. This book fills in the proton therapy gap by focusing on the physics of proton therapy, including beam production, proton interactions, biology, dosimetry, treatment planning, quality assurance, commissioning, motion management, and uncertainties. Chapters are written by the world's leading medical physicists who work at the pioneering proton treatment centers around the globe. They share their understandings after years of experience treating thousands of patients. Case studies involving specific cancer treatments show that there is some art to proton therapy as well as state-of-the-art science. Even though the focus lies on proton therapy, the content provided is also valuable to heavy charged particle th...

  11. Proton-beam radiation therapy dosimetry standardization

    International Nuclear Information System (INIS)

    Gall, K.P.

    1995-01-01

    Beams of protons have been used for radiation therapy applications for over 40 years. In the last decade the number of facilities treating patients and the total number of patients being treated has begun go grow rapidly. Due to the limited and experimental nature of the early programs, dosimetry protocols tended to be locally defined. With the publication of the AAPM Task Group 20 report open-quotes Protocol for Dosimetry of Heavy Charged Particlesclose quotes and the open-quotes European Code of Practice for Proton-Beam Dosimetryclose quotes the practice of determining dose in proton-beam therapy was somewhat unified. The ICRU has also recently commissioned a report on recommendations for proton-beam dosimetry. There have been three main methods of determining proton dose; the Faraday cup technique, the ionization chamber technique, and the calorimeter technique. For practical reasons the ionization chamber technique has become the most widely used. However, due to large errors in basic parameters (e.g., W-value) is also has a large uncertainty for absolute dose. It has been proposed that the development of water calorimeter absorbed dose standards would reduce the uncertainty in absolute proton dose as well as the relative dose between megavoltage X-ray beams and proton beams. The advantages and disadvantages are discussed

  12. Fan-beam intensity modulated proton therapy.

    Science.gov (United States)

    Hill, Patrick; Westerly, David; Mackie, Thomas

    2013-11-01

    This paper presents a concept for a proton therapy system capable of delivering intensity modulated proton therapy using a fan beam of protons. This system would allow present and future gantry-based facilities to deliver state-of-the-art proton therapy with the greater normal tissue sparing made possible by intensity modulation techniques. A method for producing a divergent fan beam of protons using a pair of electromagnetic quadrupoles is described and particle transport through the quadrupole doublet is simulated using a commercially available software package. To manipulate the fan beam of protons, a modulation device is developed. This modulator inserts or retracts acrylic leaves of varying thickness from subsections of the fan beam. Each subsection, or beam channel, creates what effectively becomes a beam spot within the fan area. Each channel is able to provide 0-255 mm of range shift for its associated beam spot, or stop the beam and act as an intensity modulator. Results of particle transport simulations through the quadrupole system are incorporated into the MCNPX Monte Carlo transport code along with a model of the range and intensity modulation device. Several design parameters were investigated and optimized, culminating in the ability to create topotherapy treatment plans using distal-edge tracking on both phantom and patient datasets. Beam transport calculations show that a pair of electromagnetic quadrupoles can be used to create a divergent fan beam of 200 MeV protons over a distance of 2.1 m. The quadrupole lengths were 30 and 48 cm, respectively, with transverse field gradients less than 20 T/m, which is within the range of water-cooled magnets for the quadrupole radii used. MCNPX simulations of topotherapy treatment plans suggest that, when using the distal edge tracking delivery method, many delivery angles are more important than insisting on narrow beam channel widths in order to obtain conformal target coverage. Overall, the sharp distal

  13. Ion beam therapy fundamentals, technology, clinical applications

    CERN Document Server

    2012-01-01

    The book provides a detailed, up-to-date account of the basics, the technology, and the clinical use of ion beams for radiation therapy. Theoretical background, technical components, and patient treatment schemes are delineated by the leading experts that helped to develop this field from a research niche to its current highly sophisticated and powerful clinical treatment level used to the benefit of cancer patients worldwide. Rather than being a side-by-side collection of articles, this book consists of related chapters. It is a common achievement by 76 experts from around the world. Their expertise reflects the diversity of the field with radiation therapy, medical and accelerator physics, radiobiology, computer science, engineering, and health economics. The book addresses a similarly broad audience ranging from professionals that need to know more about this novel treatment modality or consider to enter the field of ion beam therapy as a researcher. However, it is also written for the interested public an...

  14. Anesthesia for pediatric external beam radiation therapy

    International Nuclear Information System (INIS)

    Fortney, Jennifer T.; Halperin, Edward C.; Hertz, Caryn M.; Schulman, Scott R.

    1999-01-01

    Background: For very young patients, anesthesia is often required for radiotherapy. This results in multiple exposures to anesthetic agents over a short period of time. We report a consecutive series of children anesthetized for external beam radiation therapy (EBRT). Methods: Five hundred twelve children ≤ 16 years old received EBRT from January 1983 to February 1996. Patient demographics, diagnosis, anesthesia techniques, monitoring, airway management, complications, and outcome were recorded for the patients requiring anesthesia. Results: One hundred twenty-three of the 512 children (24%) required 141 courses of EBRT with anesthesia. Anesthetized patients ranged in age from 20 days to 11 years (mean 2.6 ± 1.8 ). The frequency of a child receiving EBRT and requiring anesthesia by age cohort was: ≤ 1 year (96%), 1-2 years (93%), 2-3 years (80%), 3-4 years (51%), 4-5 years (36%), 5-6 years (13%), 6-7 years (11%), and 7-16 years (0.7%). Diagnoses included: primary CNS tumor (28%), retinoblastoma (27%), neuroblastoma (20%), acute leukemia (9%), rhabdomyosarcoma (6%), and Wilms' tumor (4%). Sixty-three percent of the patients had been exposed to chemotherapy prior to EBRT. The mean number of anesthesia sessions per patient was 22 ± 16. Seventy-eight percent of the treatment courses were once daily and 22% were twice daily. Anesthesia techniques included: short-acting barbiturate induction + inhalation maintenance (21%), inhalation only (20%), ketamine (19%), propofol only (12%), propofol induction + inhalation maintenance (7%), ketamine induction + inhalation maintenance (6%), ketamine or short-acting barbiturate induction + inhalation maintenance (6%). Monitoring techniques included: EKG (95%), O 2 saturation (93%), fraction of inspired O 2 (57%), and end-tidal CO 2 (55%). Sixty-four percent of patients had central venous access. Eleven of the 74 children with a central line developed sepsis (15%): 6 of the 11 were anesthetized with propofol (55%), 4 with a

  15. Muon Beam Studies in the H4 beam line and the Gamma Irradiation Facility (GIF++)

    CERN Document Server

    Margraf, Rachel; CERN. Geneva. EN Department

    2017-01-01

    In this report, I summarize my work of detailed study and optimization of the muon beam configuration of H4 beam line in SPS North Area. Using Monte-Carlo simulations, I studied the properties and behavior of the muon beam in combination with the field of the large, spectrometer “ GOLIATH” magnet at -1.5, -1.0, 0, 1.0 and 1.5 Tesla, which is shown to affect the central x position of the muon beam that is delivered to the Gamma Irradiation Facility (GIF++). I also studied the muon beam for different configurations of the two XTDV beam dumps upstream of GIF++ in the H4 beam line. I will also discuss my role in mapping the magnetic field of the GOLIATH magnet in the H4 beam line.

  16. Beam Phase Detection for Proton Therapy Accelerators

    CERN Document Server

    Aminov, Bachtior; Getta, Markus; Kolesov, Sergej; Pupeter, Nico; Stephani, Thomas; Timmer, J

    2005-01-01

    The industrial application of proton cyclotrons for medical applications has become one of the important contributions of accelerator physics during the last years. This paper describes an advanced vector demodulating technique used for non-destructive measurements of beam intensity and beam phase over 360°. A computer controlled I/Q-based phase detector with a very large dynamic range of 70 dB permits the monitoring of beam intensity, phase and eventually energy for wide range of beam currents down to -130 dBm. In order to avoid interference from the fundamental cyclotron frequency the phase detection is performed at the second harmonic frequency. A digital low pass filter with adjustable bandwidth and steepness is implemented to improve accuracy. With a sensitivity of the capacitive pickup in the beam line of 30 nV per nA of proton beam current at 250 MeV, accurate phase and intensity measurements can be performed with beam currents down to 3.3 nA.

  17. On-line spectroscopy with thermal atomic beams

    International Nuclear Information System (INIS)

    Thibault, C.; Guimbal, P.; Klapisch, R.; Saint Simon, M. de; Serre, J.M.; Touchard, F.; Duong, H.T.; Jacquinot, P.; Juncar, P.

    1981-01-01

    On-line high resolution laser spectroscopy experiments have been performed in which the light from a cw tunable dye laser interacts at right angles with a thermal atomic beam. sup(76-98)Rb, sup(118-145)Cs and sup(208-213)Fr have been studied using the ionic beam delivered by the ISOLDE on-line mass separator at CERN while sup(20-31)Na and sup(38-47)K have been studied by setting the apparaturs directly on-line with the PS 20 GeV proton beam. The principle of the method is briefly explained and some results concerning nuclear structure are given. (orig.)

  18. Dose reporting in ion beam therapy. Proceedings of a meeting

    International Nuclear Information System (INIS)

    2007-06-01

    Following the pioneering work in Berkeley, USA, ion beam therapy for cancer treatment is at present offered in Chiba and Hyogo in Japan, and Darmstadt in Germany. Other facilities are coming close to completion or are at various stages of planning in Europe and Japan. In all these facilities, carbon ions have been selected as the ions of choice, at least in the first phase. Taking into account this fast development, the complicated technical and radiobiological research issues involved, and the hope it raises for some types of cancer patients, the IAEA and the International Commission on Radiation Units and measurements (ICRU) jointly sponsored a technical meeting held in Vienna, 23-24 June 2004. That first meeting was orientated mainly towards radiobiology: the relative biological effectiveness (RBE) of carbon ions versus photons, and related issues. One of the main differences between ion beam therapy and other modern radiotherapy techniques (such as proton beam therapy or intensity modulated radiation therapy) is related to radiobiology and in particular the increased RBE of carbon ions compared to both protons and photons (i.e., high linear energy transfer (LET) versus low LET radiation). Another important issue for international agencies and commissions, such as the IAEA and the ICRU, is a worldwide agreement and harmonisation for reporting the treatments. In order to evaluate the merits of ion beam therapy, it is essential that the treatments be reported in a similar/comparable way in all centres so that the clinical reports and protocols can be understood and interpreted without ambiguity by the radiation therapy community in general. For the last few decades, the ICRU has published several reports containing recommendations on how to report external photon beam or electron beam therapy, and brachytherapy. A report on proton beam therapy, jointly prepared by the ICRU and the IAEA, is now completed and is being published in the ICRU series. In line with this

  19. Beam line for experiments with coherent soft x-rays

    International Nuclear Information System (INIS)

    Howells, M.R.; Kirz, J.; Krinsky, S.

    1982-12-01

    The advantages of coherent soft x-rays for three-dimensional imaging of biological specimens are discussed, the x-ray source requirements are described, and the general design of the beam line and its optical system are given

  20. Generalized emittance measurements in a beam transport line

    International Nuclear Information System (INIS)

    Skelly, J.; Gardner, C.; Luccio, A.; Kponou, A.; Reece, K.

    1991-01-01

    Motivated by the need to commission 3 beam transport lines for the new AGS Booster project, we have developed a generalized emittance-measurement program; beam line specifics are entirely resident in data tables, not in program code. For instrumentation, the program requires one or more multi-wire profile monitors; one or multiple profiles are acquired from each monitor, corresponding to one or multiple tunes of the transport line. Emittances and Twiss parameters are calculated using generalized algorithms. The required matix descriptions of the beam optics are constructed by an on-line general beam modeling program. Design of the program, its algorithms, and initial experience with it will be described. 4 refs., 2 figs., 1 tab

  1. Water-cooled beam line components at LAMPF

    International Nuclear Information System (INIS)

    Grisham, D.L.; Lambert, J.E.

    1981-01-01

    The beam line components that comprise the main experimental beam at the Clinton P. Anderson Meson Physics Facility (LAMPF) have been operating since February 1976. This paper will define the functions of the primary water-cooled elements, their design evolution, and our operating experience to the present time

  2. Collider detector beam line test table: a structural analysis

    International Nuclear Information System (INIS)

    Leininger, M.B.

    1983-01-01

    The apparatus which sweeps calorimeter and endwall modules through the beam during testing is called a beam line test table. Because of rather stringent requirements for the physical positioning of the modules an analysis is done here to determine the modifications to the current test table design which will minimize deflections of the table under load

  3. Muon Beam Studies in the H4 beam line and the Gamma Irradiation Facility (GIF++)

    CERN Document Server

    Margraf, Rachel; CERN. Geneva. ATS Department

    2018-01-01

    In this note, we present detailed simulation results for the trajectory of a muon beam, traversing beam zones PPE-134 and PPE-154, produced by a 150 GeV positive hadron beam incident on collimators 9 & 10 in the H4 beam line when these collimators are placed off-beam axis to stop all hadrons and electrons. Using G4Beamline, a GEANT-4 based Monte-Carlo program, the trajectory of the muon beam has been studied for several field strengths of the GOLIATH magnet, as well as for different polarities. The position of the beam at the Gamma Irradiation Facility (GIF++), located downstream the PPE-144 area, is also presented. In addition, two configurations of the two XTDV’s present in the line (XTDV.022.520 and XTDV.022.610) have been studied, with the purpose to simulate the pion contamination of the beam both in PPE134 and GIF++.

  4. A line beam electron gun for rapid thermal processing

    Science.gov (United States)

    Pauli, M.; Müller, J.; Hartkopf, K.; Barth, T.

    1992-04-01

    A line beam electron gun based on the Pierce gun type was developed. The line cathode was realized by a directly heated tungsten rod. The temperature distribution along the tungsten rod was simulated numerically. The simulation shows a flat temperature across 2/3 of the cathode length and it agrees with appropriate measurable parameters. The beam profiles of the electron gun perpendicular to the line direction were examined as a function of electrical and geometrical parameters: The space-charge distribution in front of the cathode was found to be responsible for the shape of the beam profile. The shape of the beam profile is weakly influenced by the acceleration to the anode. The heating current induced voltage drop along the cathode was found to be responsible for the nonuniform emission in line direction. A model for the emission behavior of the line beam electron gun was developed. The model is based on the results of the measurements and on a numerical simulation of the potential distribution in the area between Pierce reflectors and anode. The emission model shows a solution to homogenize the emission by a suitable variation of geometrical parameters in line direction. A linear variation was realized in experiment which enables a uniform emission across 2/3 of the cathode length. The beam profile is adjustable by a bias voltage between the cathode and the Pierce reflectors.

  5. Investigation of Beam Emittance and Beam Transport Line Optics on Polarization

    Energy Technology Data Exchange (ETDEWEB)

    Fiedler, Andrew [Northern Illinois U.; Syphers, Michael [Fermilab

    2017-10-06

    Effects of beam emittance, energy spread, optical parameters and magnet misalignment on beam polarization through particle transport systems are investigated. Particular emphasis will be placed on the beam lines being used at Fermilab for the development of the muon beam for the Muon g-2 experiment, including comparisons with the natural polarization resulting from pion decay, and comments on the development of systematic correlations among phase space variables.

  6. Repeated proton beam therapy for hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Hashimoto, Takayuki; Tokuuye, Koichi; Fukumitsu, Nobuyoshi; Igaki, Hiroshi; Hata, Masaharu; Kagei, Kenji; Sugahara, Shinji; Ohara, Kiyoshi; Matsuzaki, Yasushi; Akine, Yasuyuki

    2006-01-01

    Purpose: To retrospectively evaluate the safety and effectiveness of repeated proton beam therapy for newly developed or recurrent hepatocellular carcinoma (HCC). Methods and Materials: From June 1989 through July 2000, 225 patients with HCC underwent their first course of proton beam therapy at University of Tsukuba. Of them, 27 with 68 lesions who had undergone two or more courses were retrospectively reviewed in this study. Median interval between the first and second course was 24.5 months (range 3.3-79.8 months). Median total dose of 72 Gy in 16 fractions and 66 Gy in 16 fractions were given for the first course and the rest of the courses, respectively. Results: The 5-year survival rate and median survival period from the beginning of the first course for the 27 patients were 55.6% and 62.2 months, respectively. Five-year local control rate for the 68 lesions was 87.8%. Of the patients, 1 with Child-Pugh class B and another with class C before the last course suffered from acute hepatic failure. Conclusions: Repeated proton beam therapy for HCC is safe when the patient has a target in the peripheral region of the liver and liver function is Child-Pugh class A

  7. Proposed dedicated high pressure beam lines at CHESS

    International Nuclear Information System (INIS)

    Ruoff, A.L.; Vohra, Y.K.; Bassett, W.A.; Batterman, B.W.; Bilderback, D.H.

    1988-01-01

    An instrumentation proposal for dedicated high pressure beam lines at CHESS is described. It is the purpose of this proposed program to provide researchers in high pressure science with beam lines for X-ray diffraction studies in the megabar regime. This will involve radiation from a bending magnet as well as from a wiggler. Examples of the high pressure results up to 2.16 Mbar are shown. Diffraction patterns from bending magnet and wiggler beams are shown and compared. The need for this facility by the high pressure community is discussed. (orig.)

  8. Development of slow positron beam lines and applications

    Science.gov (United States)

    Mondal, Nagendra Nath

    2018-05-01

    A positron is an antiparticle of an electron that can be formed in diverse methods: natural or artificial β-decay process, fission and fusion reactions, and a pair production of electron-positron occurred in the reactor and the high energy accelerator centers. Usually a long-lifetime radio isotope is customized for the construction of a slow positron beam lines in many laboratories. The typical intensity of this beam depends upon the strength of the positron source, moderator efficiency, and guiding, pulsing, focusing and detecting systems. This article will review a few positron beam lines and their potential applications in research, especially in the Positronium Bose-Einstein Condensation.

  9. Dosimetric consequences of pencil beam width variations in scanned beam particle therapy

    International Nuclear Information System (INIS)

    Chanrion, M A; Ammazzalorso, F; Wittig, A; Engenhart-Cabillic, R; Jelen, U

    2013-01-01

    Scanned ion beam delivery enables the highest degree of target dose conformation attainable in external beam radiotherapy. Nominal pencil beam widths (spot sizes) are recorded during treatment planning system commissioning. Due to changes in the beam-line optics, the actual spot sizes may differ from these commissioning values, leading to differences between planned and delivered dose. The purpose of this study was to analyse the dosimetric consequences of spot size variations in particle therapy treatment plans. For 12 patients with skull base tumours and 12 patients with prostate carcinoma, scanned-beam carbon ion and proton treatment plans were prepared and recomputed simulating spot size changes of (1) ±10% to simulate the typical magnitude of fluctuations, (2) ±25% representing the worst-case scenario and (3) ±50% as a part of a risk analysis in case of fault conditions. The primary effect of the spot size variation was a dose deterioration affecting the target edge: loss of target coverage and broadening of the lateral penumbra (increased spot size) or overdosage and contraction of the lateral penumbra (reduced spot size). For changes ⩽25%, the resulting planning target volume mean 95%-isodose line coverage (CI-95%) deterioration was ranging from negligible to moderate. In some cases changes in the dose to adjoining critical structures were observed. (paper)

  10. Analysis of particle species evolution in neutral beam injection lines

    International Nuclear Information System (INIS)

    Kim, J.; Haselton, H.H.

    1978-07-01

    Analytic solutions to the rate equations describing the species evolution of a multispecies positive ion beam of hydrogen due to charge exchange and molecular dissociation are derived as a function of the background gas (H 2 ) line density in the neutralizing gas cell and in the drift tube. Using the solutions, calculations are presented for the relative abundance of each species as a function of the gas cell thickness, the reionization loss rates in the drift tube, and the neutral beam power as a function of the beam energy and the species composition of the original ion beam

  11. An electromagnetically focused electron beam line source

    International Nuclear Information System (INIS)

    Iqbal, Munawar; Masood, Khalid; Rafiq, Mohammad; Chaudhary, Maqbool A.; Aleem, Fazal-e-

    2003-01-01

    A directly heated thermionic electron beam source was constructed. A tungsten wire of length 140 mm with diameter 0.9 mm was used as a cathode. An emission current of 5000 mA was achieved at an input heating power of 600 W. Cathode to anode distance of 6 mm with acceleration voltage of 10 kV was used. A uniform external magnetic field of 50 G was employed to obtain a well-focused electron beam at a deflection of 180 deg., with cathode to work site distance of 130 mm. Dimensions of the beam (1.25x120 mm) recorded at the work site were found to be in good agreement with the designed length of cathode. The deformation of the cathode was overcome by introducing a spring action mechanism, which gives uniform emission current density throughout the emission surface. We have achieved the saturation limit of the designed source resulting in smooth and swift operation of the gun for many hours (10-15 h continuously). The design of gun is so simple that it can accommodate longer cathodes for obtaining higher emission values. This gun has made it possible to coat large substrate surfaces at much faster evaporation rate at lower cost. It can also be useful in large-scale vacuum metallurgy plants for melting, welding and heat treatment

  12. Capacitive beam position monitors and automatic beam centering in the transfer lines of Ganil

    International Nuclear Information System (INIS)

    Gudewicz, P.; Petit, E.

    1991-01-01

    A non-interceptive beam position monitor, made of four capacitive electrodes, has been designed at GANIL in order to allow a permanent measurement of the ion beam position over a large intensity range (50 enA to 10 eμA). Signal processing is based on a 10 kHz heterodyne and on an amplitude to phase conversion in order to measure the beam position. An immediate application of these monitors is the automatic beam centering. For this, two algorithms have been developed using the information on the center of gravity given by the beam position monitors which is then fed back to the steerers, an iterative method and a variational method. Both methods have been used on a section of beam line and have given similar and encouraging results. The next step is to center the beam on the completely equipped line. (author) 4 refs., 2 figs., 1 tab

  13. Proton-Beam Therapy for Olfactory Neuroblastoma

    International Nuclear Information System (INIS)

    Nishimura, Hideki; Ogino, Takashi; Kawashima, Mitsuhiko; Nihei, Keiji; Arahira, Satoko; Onozawa, Masakatsu; Katsuta, Shoichi; Nishio, Teiji

    2007-01-01

    Purpose: To analyze the feasibility and efficacy of proton-beam therapy (PBT) for olfactory neuroblastoma (ONB) as a definitive treatment, by reviewing our preliminary experience. Olfactory neuroblastoma is a rare disease, and a standard treatment strategy has not been established. Radiation therapy for ONB is challenging because of the proximity of ONBs to critical organs. Proton-beam therapy can provide better dose distribution compared with X-ray irradiation because of its physical characteristics, and is deemed to be a feasible treatment modality. Methods and Materials: A retrospective review was performed on 14 patients who underwent PBT for ONB as definitive treatment at the National Cancer Center Hospital East (Kashiwa, Chiba, Japan) from November 1999 to February 2005. A total dose of PBT was 65 cobalt Gray equivalents (Gy E ), with 2.5-Gy E once-daily fractionations. Results: The median follow-up period for surviving patients was 40 months. One patient died from disseminated disease. There were two persistent diseases, one of which was successfully salvaged with surgery. The 5-year overall survival rate was 93%, the 5-year local progression-free survival rate was 84%, and the 5-year relapse-free survival rate was 71%. Liquorrhea was observed in one patient with Kadish's stage C disease (widely destroying the skull base). Most patients experienced Grade 1 to 2 dermatitis in the acute phase. No other adverse events of Grade 3 or greater were observed according to the RTOG/EORTC acute and late morbidity scoring system. Conclusions: Our preliminary results of PBT for ONB achieved excellent local control and survival outcomes without serious adverse effects. Proton-beam therapy is considered a safe and effective modality that warrants further study

  14. Phase II beam lines at the National Synchrotron Light Source

    International Nuclear Information System (INIS)

    Thomlinson, W.

    1984-06-01

    The expansion of the National Synchrotron Light Source has been funded by the US Department of Energy. The Phase II program consists of both increased conventional facilities and six new beam lines. In this paper, an overview of the six beam lines which will be constructed during Phase II is presented. For five of the lines special radiation sources are necessary and the designs of four of the devices are complete. The relevant parameters of the insertion devices under construction and development are presented

  15. A beam position feedback system for beam lines at the photon factory

    International Nuclear Information System (INIS)

    Katsura, T.; Kamiya, Y.; Haga, K.; Mitsuhashi, T.

    1987-01-01

    The beam position of the synchrotron radiation produced from the Storage Ring was stabilized by a twofold position feedback system. A digital feedback system was developed to suppress the diurnal beam movement (one cycle of sin-like drifting motion per day) which became a serious problem in low-emittance operation. The feedback was applied to the closed-orbit-distortion (COD) correction system in order to cancel the position variation at all the beam lines proportionately to the variation monitored at one beam line. An analog feedback system is also used to suppress frequency components faster than the slow diurnal movement

  16. Realization of compact tractor beams using acoustic delay-lines

    Science.gov (United States)

    Marzo, A.; Ghobrial, A.; Cox, L.; Caleap, M.; Croxford, A.; Drinkwater, B. W.

    2017-01-01

    A method for generating stable ultrasonic levitation of physical matter in air using single beams (also known as tractor beams) is demonstrated. The method encodes the required phase modulation in passive unit cells into which the ultrasonic sources are mounted. These unit cells use waveguides such as straight and coiled tubes to act as delay-lines. It is shown that a static tractor beam can be generated using a single electrical driving signal, and a tractor beam with one-dimensional movement along the propagation direction can be created with two signals. Acoustic tractor beams capable of holding millimeter-sized polymer particles of density 1.25 g/cm3 and fruit-flies (Drosophila) are demonstrated. Based on these design concepts, we show that portable tractor beams can be constructed with simple components that are readily available and easily assembled, enabling applications in industrial contactless manipulation and biophysics.

  17. The beam diagnostic instruments in Beijing radioactive ion-beam facilities isotope separator on-line

    International Nuclear Information System (INIS)

    Ma, Y.; Cui, B.; Ma, R.; Tang, B.; Chen, L.; Huang, Q.; Jiang, W.

    2014-01-01

    The beam diagnostic instruments for Beijing Radioactive Ion-beam Facilities Isotope Separator On-Line are introduced [B. Q. Cui, Z. H. Peng, Y. J. Ma, R. G. Ma, B. Tang, T. Zhang, and W. S. Jiang, Nucl. Instrum. Methods 266, 4113 (2008); T. J. Zhang, X. L. Guan, and B. Q. Cui, in Proceedings of APAC 2004, Gyeongju, Korea, 2004, http://www.jacow.org , p. 267]. For low intensity ion beam [30–300 keV/1 pA–10 μA], the beam profile monitor, the emittance measurement unit, and the analyzing slit will be installed. For the primary proton beam [100 MeV/200 μA], the beam profile scanner will be installed. For identification of the nuclide, a beam identification unit will be installed. The details of prototype of the beam diagnostic units and some experiment results will be described in this article

  18. On-line monitoring of heavy-ion therapy using PET

    International Nuclear Information System (INIS)

    Pavlovic, M.

    2004-01-01

    In this presentation authors present results of on-line monitoring of heavy-ion therapy using PET. It is concluded that in-beam positron emission tomography is a feasible and valuable method for in-situ and non-invasive monitoring of heavy-ion therapy

  19. Design and development of radiation absorber for sighting beam line

    International Nuclear Information System (INIS)

    Sridhar, R.; Shukla, S.K.

    2005-01-01

    During the commissioning of Indus-2 , it is necessary to view the synchrotron radiation that will be emanating from the dipole exit ports. The 10 0 beam line from dipole 11 was earmarked for sighting beam line. The synchrotron radiation power density would be around 340 watts on the photon absorber inside the radiation absorber module, at the specified beam power of Indus-2. The beam striking on this photon absorber produces x-rays and Bremsstrahlung radiation. These are to be stopped and absorbed by radiation absorber. The photon absorber and the radiation absorber are integrated in a single vacuum chamber and actuated by a pneumatic cylinder connected using a bellow. Radiation absorber was needed to isolate the diagnostic components and to protect them from radiation a well as heat when they were not in use. The paper describes the design, calculation and development of the dynamic photon cum radiation absorber. The ultimate vacuum performance is also described. (author)

  20. Construction of a pulsed MeV positron beam line

    Energy Technology Data Exchange (ETDEWEB)

    Masuno, Shin-ichi; Okada, Sohei; Kawasuso, Atsuo [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    1997-03-01

    To develop a fast (1 MeV) and short pulsed (100 ps) positron beam which enables defect behavior analysis of bulk states of materials even at high temperatures where a usual positron source would melt, we have been performing design study and construction of the beam line in a three-year program since 1994. This report describes the components, design study results and experimental results of the completed parts until now. (author)

  1. Bending magnets for the CBA beam-transport line

    International Nuclear Information System (INIS)

    Thern, R.E.

    1983-01-01

    The beam-transport line from the AGS to CBA requires 68 large bending magnets, consisting of pure dipoles and two types of combined function gradient magnets. All three types were designed with magnetic-field calculation program POISSON, using the same exterior dimensions and coil package. The design goal of +-1% momentum acceptance for the transport line required a wide horizontal aperture, with a much-smaller vertical aperture for economy. Two prototypes of one gradient magnet were built, and a facility constructed to measure them and the later production magnets. Measurements were done using both a long coil and a point coil (Rawson-Lush gaussmeter). Preliminary results show δB/B - 3 , δG/G - 2 , and δB 2 /B - 4 cm - 2 over the beam aperture. Due to end effects, the actual gradient differs from the design gradient by 1%, which has been compensated for in the beam-line design

  2. Simulating the Beam-line at CERN's ISOLDE Experiment

    CERN Document Server

    McGrath, Casey

    2013-01-01

    Maximizing the optical matching along portions of the ISOLDE beam-line and automating this procedure will make it easier for scientists to determine what the strengths of the electrical elds of each beam-line element should be in order to reduce particle loss. Simulations are run using a program called MAD-X, however, certain issues were discovered that hindered an immediate success of the simulations. Specifically, the transfer matrices for electrostatic components like the switchyards, kickers, and electric quadrupoles were missing from the original coding. The primary aim of this project was to design these components using AutoCAD and then extract the transfer matrices using SIMION. Future work will then implement these transfer matrices into the MAD-X code to make the simulations of the beam-line more accurate.

  3. Ion-optical studies for a range adaptation method in ion beam therapy using a static wedge degrader combined with magnetic beam deflection

    International Nuclear Information System (INIS)

    Chaudhri, Naved; Saito, Nami; Bert, Christoph; Franczak, Bernhard; Steidl, Peter; Durante, Marco; Schardt, Dieter; Rietzel, Eike

    2010-01-01

    Fast radiological range adaptation of the ion beam is essential when target motion is mitigated by beam tracking using scanned ion beams for dose delivery. Electromagnetically controlled deflection of a well-focused ion beam on a small static wedge degrader positioned between two dipole magnets, inside the beam delivery system, has been considered as a fast range adaptation method. The principle of the range adaptation method was tested in experiments and Monte Carlo simulations for the therapy beam line at the GSI Helmholtz Centre for Heavy Ions Research. Based on the simulations, ion optical settings of beam deflection and realignment of the adapted beam were experimentally applied to the beam line, and additional tuning was manually performed. Different degrader shapes were employed for the energy adaptation. Measured and simulated beam profiles, i.e. lateral distribution and range in water at isocentre, were analysed and compared with the therapy beam values for beam scanning. Deflected beam positions of up to ±28 mm on degrader were performed which resulted in a range adaptation of up to ±15 mm water equivalence (WE). The maximum deviation between the measured adapted range from the nominal range adaptation was below 0.4 mm WE. In experiments, the width of the adapted beam at the isocentre was adjustable between 5 and 11 mm full width at half maximum. The results demonstrate the feasibility/proof of the proposed range adaptation method for beam tracking from the beam quality point of view.

  4. Optimum field size and choice of isodose lines in electron beam treatment

    International Nuclear Information System (INIS)

    Das, Indra J.; Cheng, Chee W.; Healey, Glenn A.

    1995-01-01

    Purpose: A method is provided for the optimum field size and the choice of isodose line for the dose prescription in electron beam therapy. Methods and Materials: Electron beam dose uniformity was defined in terms of target coverage factor (TCF) which is an index of dose coverage of a given treatment volume. The TCF was studied with respect to the field size, the beam energy, and the isodose level for prescription from the measured data for various accelerators. The effect of the TCF on air gap between electron applicator/cone and the surface was investigated. Electron beams from scattering foil and scanned beam units were analyzed for the target coverage. Results: A mathematical method is provided to optimize a field size for target coverage by a given isodose line in terms of TCF which is strongly dependent on the type of accelerator and the design of the collimator. For a given type of collimating system, the TCF does not depend on the type of electron beam production (scattering foil or swept scanned beam). Selection of isodose line for dose prescription is very critical for the value of the TCF and the dose coverage. The TCF is inversely proportional to the isodose value selected for the treatment and nearly linear with field size and beam energy. Air gap between applicator and the surface reduces the dose uniformity. Tertiary collimator moderately improves the lateral coverage for high energy beams. Conclusions: To adequately cover the target volume in electron beam treatment, lateral and depth coverage should be considered. The coverage at depth is strongly dependent on the choice of isodose line or beam normalization. If the dose prescription is at d max (i.e., the 100% isodose line is selected), the choice of beam energy is not critical for depth coverage since d max is nearly independent of energy for smaller fields. The 100% isodose line should not be chosen for treatment because of the significant constriction of this isodose line and inadequate

  5. Note: Characteristic beam parameter for the line electron gun

    Science.gov (United States)

    Iqbal, M.; Islam, G. U.; Zhou, Z.; Chi, Y.

    2013-11-01

    We have optimized the beam parameters of line source electron gun using Stanford Linear Accelerator Centre electron beam trajectory program (EGUN), utilizing electrostatic focusing only. We measured minimum beam diameter as 0.5 mm that corresponds to power density of 68.9 kW/cm2 at 13.5 mm in the post-anode region which is more than two-fold (33 kW/cm2), of the previously reported results. The gun was operated for the validation of the theoretical results and found in good agreement. The gun is now without any magnetic and electrostatic focusing thus much simpler and more powerful.

  6. Note: Characteristic beam parameter for the line electron gun

    Energy Technology Data Exchange (ETDEWEB)

    Iqbal, M. [Centre for High Energy Physics, University of the Punjab, Lahore 45590 (Pakistan); Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Islam, G. U. [Centre for High Energy Physics, University of the Punjab, Lahore 45590 (Pakistan); Zhou, Z.; Chi, Y. [Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China)

    2013-11-15

    We have optimized the beam parameters of line source electron gun using Stanford Linear Accelerator Centre electron beam trajectory program (EGUN), utilizing electrostatic focusing only. We measured minimum beam diameter as 0.5 mm that corresponds to power density of 68.9 kW/cm{sup 2} at 13.5 mm in the post-anode region which is more than two-fold (33 kW/cm{sup 2}), of the previously reported results. The gun was operated for the validation of the theoretical results and found in good agreement. The gun is now without any magnetic and electrostatic focusing thus much simpler and more powerful.

  7. Note: Characteristic beam parameter for the line electron gun

    International Nuclear Information System (INIS)

    Iqbal, M.; Islam, G. U.; Zhou, Z.; Chi, Y.

    2013-01-01

    We have optimized the beam parameters of line source electron gun using Stanford Linear Accelerator Centre electron beam trajectory program (EGUN), utilizing electrostatic focusing only. We measured minimum beam diameter as 0.5 mm that corresponds to power density of 68.9 kW/cm 2 at 13.5 mm in the post-anode region which is more than two-fold (33 kW/cm 2 ), of the previously reported results. The gun was operated for the validation of the theoretical results and found in good agreement. The gun is now without any magnetic and electrostatic focusing thus much simpler and more powerful

  8. Note: Characteristic beam parameter for the line electron gun.

    Science.gov (United States)

    Iqbal, M; Islam, G U; Zhou, Z; Chi, Y

    2013-11-01

    We have optimized the beam parameters of line source electron gun using Stanford Linear Accelerator Centre electron beam trajectory program (EGUN), utilizing electrostatic focusing only. We measured minimum beam diameter as 0.5 mm that corresponds to power density of 68.9 kW/cm(2) at 13.5 mm in the post-anode region which is more than two-fold (33 kW/cm(2)), of the previously reported results. The gun was operated for the validation of the theoretical results and found in good agreement. The gun is now without any magnetic and electrostatic focusing thus much simpler and more powerful.

  9. Beam transfer line for food irradiation microtron at CAT

    International Nuclear Information System (INIS)

    Kant, Pradeep; Singh, Gurnam

    2003-01-01

    A 10 MeV microtron is being developed at CAT for irradiation of food products. A beam transfer line comprising a 90 deg bending magnet, a quadrupole doublet and a rectangular scanning magnet has been designed to irradiate food products from the upper side. The bending magnet has an edge angle of 22.5 deg. The length of the beam transfer line has been minimized to keep the whole unit as compact as possible. The beam optics has been optimized keeping in view the requirement of a small beam pipe aperture (25mm radius) and a large range of circular as well as elliptical beam sizes on the food product. The speed of the conveyor belt has been assumed to be very small. The results of the beam optics chosen and the variation of the linear charge density on a food product during the scanning are presented in this paper. The effects of path length variation within the scanning magnet and beam size variation during a scanning are also discussed

  10. Beam Dump Design for the Rare Isotope Accelerator Fragmentation Line

    Energy Technology Data Exchange (ETDEWEB)

    Stein, W; Ahle, L E; Reyes, S

    2006-05-02

    Beam dumps for the heavy ion beams of the fragmentation line of the Rare Isotope Accelerator have been designed. The most severe operational case involves a continuous U beam impacting the beam dump with a power of 295 kW and a nominal spot diameter size of 5 cm. The dump mechanically consists of two rotating barrels with a water cooled outer wall of 2 mm thick aluminum. The barrels are 70 cm in diameter and axially long enough to intercept a variety of other beams. The aluminum wall absorbs approximately 15% of the U beam power with the rest absorbed in the water downstream of the wall. The water acts as an absorber of the beam and as a coolant for the 2 mm aluminum wall. The barrel rotates at less than 400 RPM, maximum aluminum temperatures are less than 100 C and maximum thermal fatigue stresses are low at 3.5 x 10{sup 7} Pa (5 ksi). Rotation of the dump results in relatively low radiation damage levels with an operating lifetime of years for most beams.

  11. FIRST BEAM TESTS OF THE MUON COLLIDER TARGET TEST BEAM LINE AT THE AGS

    International Nuclear Information System (INIS)

    BROWN, K.A.; GASSNER, D.; GLENN, J.W.; PRIGL, R.; SIMOS, N.; SCADUTO, J.; TSOUPAS, N.

    2001-01-01

    In this report we will describe the muon collider target test beam line which operates off one branch of the AGS switchyard. The muon collider target test facility is designed to allow a prototype muon collider target system to be developed and studied. The beam requirements for the facility are ambitious but feasible. The system is designed to accept bunched beams of intensities up to 1.6 x 10 13 24 GeV protons in a single bunch. The target specifications require beam spot sizes on the order of 1 mm, 1 sigma rms at the maximum intensity. We will describe the optics design, the instrumentation, and the shielding design. Results from the commissioning of the beam line will be shown

  12. E-line: A new crystal collimator beam line for source size measurements at CHESS

    Energy Technology Data Exchange (ETDEWEB)

    White, Jeffrey A. [CHESS, Cornell High Energy Synchrotron Source, Cornell University, Ithaca, NY 14850-8001 (United States)], E-mail: jaw7@cornell.edu; Revesz, Peter; Finkelstein, Ken [CHESS, Cornell High Energy Synchrotron Source, Cornell University, Ithaca, NY 14850-8001 (United States)

    2007-11-11

    A new X-ray beam line has been constructed at cornell high energy synchrotron source (CHESS) to measure the vertical and horizontal source size of the positron particle beam. The cornell laboratory of elementary particle physics (LEPP) operates the storage ring (CESR) for X-ray generation for the CHESS user community by circulating electrons and their antimatter counterpart positrons in counter-rotating beams. As the laboratory reduces the emittances of particle beams to increase X-ray brilliance, there has been an increasing need for diagnostic tools to measure and monitor source size. A beam line front end that accesses the positron synchrotron light has been fitted with an experimental chamber and apparatus of compact design capable of horizontal and vertical source size measurement using the 'crystal collimator' technique, and an additional setup for vertical beam position monitoring using a luminescence-based X-ray video beam position monitoring system. The crystal collimators each consist of two Si(2 2 0) crystals in a dispersive (+,+) arrangement that diffract X-rays to a fluorescent material coated on a view port observed with a CCD camera. Measurements of the positron vertical beam size using the crystal collimation method at E-line are compared with measurements of visible synchrotron light at a remotely located dedicated port on the storage ring.

  13. E-line: A new crystal collimator beam line for source size measurements at CHESS

    International Nuclear Information System (INIS)

    White, Jeffrey A.; Revesz, Peter; Finkelstein, Ken

    2007-01-01

    A new X-ray beam line has been constructed at cornell high energy synchrotron source (CHESS) to measure the vertical and horizontal source size of the positron particle beam. The cornell laboratory of elementary particle physics (LEPP) operates the storage ring (CESR) for X-ray generation for the CHESS user community by circulating electrons and their antimatter counterpart positrons in counter-rotating beams. As the laboratory reduces the emittances of particle beams to increase X-ray brilliance, there has been an increasing need for diagnostic tools to measure and monitor source size. A beam line front end that accesses the positron synchrotron light has been fitted with an experimental chamber and apparatus of compact design capable of horizontal and vertical source size measurement using the 'crystal collimator' technique, and an additional setup for vertical beam position monitoring using a luminescence-based X-ray video beam position monitoring system. The crystal collimators each consist of two Si(2 2 0) crystals in a dispersive (+,+) arrangement that diffract X-rays to a fluorescent material coated on a view port observed with a CCD camera. Measurements of the positron vertical beam size using the crystal collimation method at E-line are compared with measurements of visible synchrotron light at a remotely located dedicated port on the storage ring

  14. On setting magnets in the PEP beam-transport line

    International Nuclear Information System (INIS)

    Peterson, J.M.

    1979-01-01

    This paper discusses magnets in the PEP beam-transport line. Topics discussed are: conditioning, direction of excitation, rate of excitation; determination of the excitation current for the principal bend magnets; steering mechanisms; bump magnets; and determination of excitation currents of the quadrupole magnets

  15. A polarized beam for the M-3 line

    International Nuclear Information System (INIS)

    Underwood, D.; Colton, E.; Halpern, H.

    1978-01-01

    A beamline is proposed for polarized protons to be built in the M-3 line of the Meson Laboratory utilizing lambda decays. This beamline would provide a clean source of polarized protons or an enriched beam of antiprotons or polarized antiprotons

  16. Preliminary design of electrostatic sensors for MITICA beam line components

    Energy Technology Data Exchange (ETDEWEB)

    Spagnolo, S., E-mail: spagnolo@igi.cnr.it; Spolaore, M.; Dalla Palma, M.; Pasqualotto, R.; Sartori, E.; Serianni, G.; Veltri, P. [Consorzio RFX, Associazione EURATOM-ENEA sulla Fusione, 35127 Padova (Italy)

    2016-02-15

    Megavolt ITER Injector and Concept Advancement, the full-scale prototype of ITER neutral beam injector, is under construction in Italy. The device will generate deuterium negative ions, then accelerated and neutralized. The emerging beam, after removal of residual ions, will be dumped onto a calorimeter. The presence of plasma and its parameters will be monitored in the components of the beam-line, by means of specific electrostatic probes. Double probes, with the possibility to be configured as Langmuir probes and provide local ion density and electron temperature measurements, will be employed in the neutralizer and in the residual ion dump. Biased electrodes collecting secondary emission electrons will be installed in the calorimeter with the aim to provide a horizontal profile of the beam.

  17. Fast pencil beam dose calculation for proton therapy using a double-Gaussian beam model

    Directory of Open Access Journals (Sweden)

    Joakim eda Silva

    2015-12-01

    Full Text Available The highly conformal dose distributions produced by scanned proton pencil beams are more sensitive to motion and anatomical changes than those produced by conventional radiotherapy. The ability to calculate the dose in real time as it is being delivered would enable, for example, online dose monitoring, and is therefore highly desirable. We have previously described an implementation of a pencil beam algorithm running on graphics processing units (GPUs intended specifically for online dose calculation. Here we present an extension to the dose calculation engine employing a double-Gaussian beam model to better account for the low-dose halo. To the best of our knowledge, it is the first such pencil beam algorithm for proton therapy running on a GPU. We employ two different parametrizations for the halo dose, one describing the distribution of secondary particles from nuclear interactions found in the literature and one relying on directly fitting the model to Monte Carlo simulations of pencil beams in water. Despite the large width of the halo contribution, we show how in either case the second Gaussian can be included whilst prolonging the calculation of the investigated plans by no more than 16%, or the calculation of the most time-consuming energy layers by about 25%. Further, the calculation time is relatively unaffected by the parametrization used, which suggests that these results should hold also for different systems. Finally, since the implementation is based on an algorithm employed by a commercial treatment planning system, it is expected that with adequate tuning, it should be able to reproduce the halo dose from a general beam line with sufficient accuracy.

  18. External beam radiation therapy for prostate cancer

    International Nuclear Information System (INIS)

    Forman, Jeffrey D.

    1996-01-01

    Purpose/Objectives: The intent of this course is to review the issues involved in the management of non-metastatic adenocarcinoma of the prostate. -- The value of pre-treatment prognostic factors including stage, grade and PSA value will be presented, and their value in determining therapeutic strategies will be discussed. -- Controversies involving the simulation process and treatment design will be presented. The value of CT scanning, Beams-Eye View, 3-D planning, intravesicle, intraurethral and rectal contrast will be presented. The significance of prostate and patient movement and strategies for dealing with them will be presented. -- The management of low stage, low to intermediate grade prostate cancer will be discussed. The dose, volume and timing of irradiation will be discussed as will the role of neo-adjuvant hormonal therapy, neutron irradiation and brachytherapy. The current status of radical prostatectomy and cryotherapy will be summarized. Treatment of locally advanced, poorly differentiated prostate cancer will be presented including a discussion of neo-adjuvant and adjuvant hormones, dose-escalation and neutron irradiation. -- Strategies for post-radiation failures will be presented including data on cryotherapy, salvage prostatectomy and hormonal therapy (immediate, delayed and/or intermittent). New areas for investigation will be reviewed. -- The management of patients post prostatectomy will be reviewed. Data on adjuvant radiation and therapeutic radiation for biochemical or clinically relapsed patients will be presented. This course hopes to present a realistic and pragmatic overview for treating patients with non-metastatic prostatic cancer

  19. Characteristics of Sissi beams in the transport lines of Ganil

    International Nuclear Information System (INIS)

    Nghiem, P.; Payet, J.; Tkatchenko, A.

    1994-01-01

    This study is the following of the Sissi primary beam characteristics definition. Its aim is to determine the performances in resolution and in transmission of transport lines which guide the secondary beams until the experimentation rooms. The first part concerns the study of the secondary order characteristics with the help of BETA matrix code for the nominal case. The second part is the same study but but of superior orders carried out with the Zgoubi program. The third part consists to search new regulating to minimise the losses of particles due to the effect of non-linearity. (O.L.). 3 refs., 34 figs., 5 tabs

  20. Neutronics Assessments for a RIA Fragmentation Line Beam Dump Concept

    CERN Document Server

    Boles, Jason; Reyes, Susana; Stein, Werner

    2005-01-01

    Heavy ion and radiation transport calculations are in progress for conceptual beam dump designs for the fragmentation line of the proposed Rare Isotope Accelerator (RIA). Using the computer code PHITS, a preliminary design of a motor-driven rotating wheel beam dump and adjacent downstream multipole has been modeled. Selected results of these calculations are given, including neutron and proton flux in the wheel, absorbed dose and displacements per atom in the hub materials, and heating from prompt radiation and from decay heat in the multipole.

  1. Beam position measurement in transport line-1 of Indus accelerator

    International Nuclear Information System (INIS)

    Ojha, Avanish; Yadav, Surendra; Holikatti, Anil C.; Puntambekar, T.A.; Pithawa, C.K.

    2011-01-01

    In Indus Accelerator Complex at RRCAT Indore, 20 MeV electron beam is transported from injector Microtron to Booster Synchrotron through Transport Line-1 (TL-1). This beam has nominal pulse width of 500 ns with repetition rate of 1 Hz. A split electrode type beam position Indicator (BPI) is planned to be used to detect position of beam in TL-1, for which a four-channel processing electronics has been designed and developed. The circuit consists of microcontroller based four-channel peak detector circuit followed by multiplexer and ADC. The microcontroller is triggered from the timing system of microtron, which enables microcontroller to control and synchronize various parts of electronics. Microcontroller also sends the digitized data to a PC on serial link. During development, a problem of overcharging of capacitor was faced, which was resulting in false peak detection. Circuit was simulated and necessary modifications were incorporated in the circuit to solve this problem. A test setup with provision to simulate the beam signal using an antenna was used for testing the circuit in lab and a suitable Graphical User Interface (GUI) program was developed in LabVIEW. This GUI can also be used to calibrate the BPI. The prototype BPI was tested under simulated beam condition, which gave positional accuracy of ± 200 microns. (author)

  2. The H line: a brand new beam line for fundamental physics at the J-PARC muon facility

    International Nuclear Information System (INIS)

    Kawamura, N; Shimomura, K; Miyake, Y; Toyoda, A; Saito, N; Mihara, S; Aoki, M

    2013-01-01

    The muon facility, J-PARC (Muon Science Establishment; MUSE), has been operated since first beam in 2008. Starting with a 200 kW proton beam, the beam intensity has reached 3×10 6 / muons/s, the most intense pulsed muon beam in the world. A 2 cm thick graphite target permits the extraction of four secondary muon beams. A brand new beam line, the H line, is planned to be constructed. The new beam line is designed to have a large acceptance, will provide the ability to tune the momentum, and use a kicker magnet and/or Wien filter. This beam line will provide an intense beam for experiments that require high statistics and must occupy the experimental areas for a relatively long period.

  3. Beam manipulation and acceleration with Dielectric-Lined Waveguides

    Energy Technology Data Exchange (ETDEWEB)

    Lemery, Francois [Northern Illinois Univ., DeKalb, IL (United States)

    2015-06-01

    The development of next-generation TeV+ electron accelerators will require either immense footprints based on conventional acceleraton techniques or the development of new higher{gradient acceleration methods. One possible alternative is beam-driven acceleration in a high-impedance medium such as a dielectric-lined-waveguide (DLW), where a highcharge bunch passes through a DLW and can excite gradients on the order of GV/m. An important characteristic of this acceleration class is the transformer ratio which characterizes the energy transfer of the scheme. This dissertation discusses alternative methods to improve the transformer ratio for beam-driven acceleration and also considers the use of DLWs for beam manipulation at low energy.

  4. Moving strip technique of electron beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Matsushima, Kishio; Wakasa, Hiroyuki; Oguri, Nobuhiro; Kitayama, Takuichi; Nakagiri, Yoshitada; Mikami, Yasutaka; Hashimoto, Keiji; Hiraki, Yoshio; Aono, Kaname

    1984-12-01

    The fieldsize in electron beam therapy is determined by the cone size. In case of skin metastasis of a malignant tumor and so on, which need a large field size and whose area is much larger than the size of the cone, a large field size is usually produced by dividing the portals. However, the dose distribution at the border of the field becomes unequal, and hot and cold dose areas are produced according to the distance between portals. We tried the strip field technique in a large field along the long axis of the body in order to flatten the dose of the border employing the moving strip used for whole abdominal irradiation in ovarian cancer. We set the film in Mix-DP and used the strip field technique with 2.5cm steps. We discussed the relationship between the interval (distance between portals) and the flattening of the dose within the field. Skin movement due to breathing and influences on the flattening of the dose were considered. The proper flatness was obtained at depths of 0,1,2, and 3cm by setting the interval at 0.5cm. When skin movement was produced by breathing in +-1.5mm, the proper flaness was obtained also at a 0.5-cm interval. It seems that smoothing is increased by breathing. An ''electron beam moving strip'' with a 2.5-cm step and 0.5-cm interval was clinically effective in the treatment of patients with skin metastasis of colon cancer. (author).

  5. Beam line design for synchrotron spectroscopy in the VUV

    Energy Technology Data Exchange (ETDEWEB)

    Howells, M R

    1980-01-01

    The character of the radiation source provided by an electron storage ring is briefly reviewed from the point of view of utilization for VUV spectroscopy. The design of beam line components is then considered with special reference to the problems of contamination of optical surfaces and vacuum protection. The issues involved in designing mirrors for use with storage rings are considered with emphasis on the questions of power dissipation, image quality and materials selection.

  6. Beam line design for synchrotron spectroscopy in the VUV

    International Nuclear Information System (INIS)

    Howells, M.R.

    1980-01-01

    The character of the radiation source provided by an electron storage ring is briefly reviewed from the point of view of utilization for VUV spectroscopy. The design of beam line components is then considered with special reference to the problems of contamination of optical surfaces and vacuum protection. The issues involved in designing mirrors for use with storage rings are considered with emphasis on the questions of power dissipation, image quality and materials selection

  7. Bending magnets for the CBA beam-transport line

    Energy Technology Data Exchange (ETDEWEB)

    Thern, R.E.

    1983-01-01

    The beam-transport line from the AGS to CBA requires 68 large bending magnets, consisting of pure dipoles and two types of combined function gradient magnets. All three types were designed with magnetic-field calculation program POISSON, using the same exterior dimensions and coil package. The design goal of +-1% momentum acceptance for the transport line required a wide horizontal aperture, with a much-smaller vertical aperture for economy. Two prototypes of one gradient magnet were built, and a facility constructed to measure them and the later production magnets. Measurements were done using both a long coil and a point coil (Rawson-Lush gaussmeter). Preliminary results show ..delta..B/B < 0.2 x 10/sup -3/, ..delta..G/G < 0.3 x 10/sup -2/, and ..delta..B/sub 2//B < 0.3 x 10/sup -4/ cm/sup -2/ over the beam aperture. Due to end effects, the actual gradient differs from the design gradient by 1%, which has been compensated for in the beam-line design.

  8. Modeling the biophysical effects in a carbon beam delivery line by using Monte Carlo simulations

    Science.gov (United States)

    Cho, Ilsung; Yoo, SeungHoon; Cho, Sungho; Kim, Eun Ho; Song, Yongkeun; Shin, Jae-ik; Jung, Won-Gyun

    2016-09-01

    The Relative biological effectiveness (RBE) plays an important role in designing a uniform dose response for ion-beam therapy. In this study, the biological effectiveness of a carbon-ion beam delivery system was investigated using Monte Carlo simulations. A carbon-ion beam delivery line was designed for the Korea Heavy Ion Medical Accelerator (KHIMA) project. The GEANT4 simulation tool kit was used to simulate carbon-ion beam transport into media. An incident energy carbon-ion beam with energy in the range between 220 MeV/u and 290 MeV/u was chosen to generate secondary particles. The microdosimetric-kinetic (MK) model was applied to describe the RBE of 10% survival in human salivary-gland (HSG) cells. The RBE weighted dose was estimated as a function of the penetration depth in the water phantom along the incident beam's direction. A biologically photon-equivalent Spread Out Bragg Peak (SOBP) was designed using the RBE-weighted absorbed dose. Finally, the RBE of mixed beams was predicted as a function of the depth in the water phantom.

  9. Nanoscale insights into ion-beam cancer therapy

    CERN Document Server

    2017-01-01

    This book provides a unique and comprehensive overview of state-of-the-art understanding of the molecular and nano-scale processes that play significant roles in ion-beam cancer therapy. It covers experimental design and methodology, and reviews the theoretical understanding of the processes involved. It offers the reader an opportunity to learn from a coherent approach about the physics, chemistry and biology relevant to ion-beam cancer therapy, a growing field of important medical application worldwide. The book describes phenomena occurring on different time and energy scales relevant to the radiation damage of biological targets and ion-beam cancer therapy from the molecular (nano) scale up to the macroscopic level. It illustrates how ion-beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue whilst maximizing cell-killing within the tumour, offering a significant development in cancer therapy. The full potential ...

  10. Synchrotron accelerator technology for proton beam therapy with high accuracy

    International Nuclear Information System (INIS)

    Hiramoto, Kazuo

    2009-01-01

    Proton beam therapy was applied at the beginning to head and neck cancers, but it is now extended to prostate, lung and liver cancers. Thus the need for a pencil beam scanning method is increasing. With this method radiation dose concentration property of the proton beam will be further intensified. Hitachi group has supplied a pencil beam scanning therapy system as the first one for M. D. Anderson Hospital in United States, and it has been operational since May 2008. Hitachi group has been developing proton therapy system to correspond high-accuracy proton therapy to concentrate the dose in the diseased part which is located with various depths, and which sometimes has complicated shape. The author described here on the synchrotron accelerator technology that is an important element for constituting the proton therapy system. (K.Y.)

  11. Diagnostic tools used in the calibration and verification of protein crystallography synchrotron beam lines and apparatus

    International Nuclear Information System (INIS)

    Rotella, F.J.; Alkire, R.W.; Duke, N.E.C.; Molitsky, M.J.

    2011-01-01

    Diagnostic tools have been developed for use at the Structural Biology Center beam lines at the Advanced Photon Source. These tools are used in the calibration and operating verification of these synchrotron X-ray beam lines and constituent equipment.

  12. Parametric study of transport beam lines for electron beams accelerated by laser-plasma interaction

    Science.gov (United States)

    Scisciò, M.; Lancia, L.; Migliorati, M.; Mostacci, A.; Palumbo, L.; Papaphilippou, Y.; Antici, P.

    2016-03-01

    In the last decade, laser-plasma acceleration of high-energy electrons has attracted strong attention in different fields. Electrons with maximum energies in the GeV range can be laser-accelerated within a few cm using multi-hundreds terawatt (TW) lasers, yielding to very high beam currents at the source (electron bunches with up to tens-hundreds of pC in a few fs). While initially the challenge was to increase the maximum achievable electron energy, today strong effort is put in the control and usability of these laser-generated beams that still lack of some features in order to be used for applications where currently conventional, radio-frequency (RF) based, electron beam lines represent the most common and efficient solution. Several improvements have been suggested for this purpose, some of them acting directly on the plasma source, some using beam shaping tools located downstream. Concerning the latter, several studies have suggested the use of conventional accelerator magnetic devices (such as quadrupoles and solenoids) as an easy implementable solution when the laser-plasma accelerated beam requires optimization. In this paper, we report on a parametric study related to the transport of electron beams accelerated by laser-plasma interaction, using conventional accelerator elements and tools. We focus on both, high energy electron beams in the GeV range, as produced on petawatt (PW) class laser systems, and on lower energy electron beams in the hundreds of MeV range, as nowadays routinely obtained on commercially available multi-hundred TW laser systems. For both scenarios, our study allows understanding what are the crucial parameters that enable laser-plasma accelerators to compete with conventional ones and allow for a beam transport. We show that suitable working points require a tradeoff-combination between low beam divergence and narrow energy spread.

  13. Secondary beam line phase space measurement and modeling at LAMPF

    International Nuclear Information System (INIS)

    Floyd, R.; Harrison, J.; Macek, R.; Sanders, G.

    1979-01-01

    Hardware and software have been developed for precision on-line measurement and fitting of secondary beam line phase space parameters. A system consisting of three MWPC planes for measuring particle trajectories, in coincidence with a time-of-flight telescope and a range telescope for particle identification, has been interfaced to a computer. Software has been developed for on-line track reconstruction, application of experimental cuts, and fitting of two-dimensional phase space ellipses for each particle species. The measured distributions have been found to agree well with the predictions of the Monte Carlo program DECAY TURTLE. The fitted phase space ellipses are a useful input to optimization routines, such as TRANSPORT, used to search for superior tunes. Application of this system to the LAMPF Stopped Muon Channel is described

  14. Beam optics of the AmPS extraction line

    International Nuclear Information System (INIS)

    Hoekstra, R.

    1991-01-01

    The design of the Amsterdam Pulse Stretcher includes a feasibility study of part of the extraction trajectory. The latter includes some proposed curves projected through the hall of the beam switch yard. Since extraction is performed in the north line of the ring and the connection to the trajectory of the spectrometers is planned in a trajectory parallel to the east line of the ring the curves contain bending magnets for bending 90 degrees either by only two magnets or by making use of ring bending magnets in the same way as the ring curves are constructed. The bending through 90 degrees has optimal imaging properties of a unit cell much the same as the curves in the ring. This one-to-one (or one-to-minus-one) property is intended to shift the known required beam dimensions stream upwards from a defined point in the trajectory of the spectrometers to be able to create the dimensions at this shifted point by means of a so called beam transformer, placed in between the extraction point and this position. This report deals with the further developments with respect to the extraction trajectory. (author). 5 refs.; 9 figs.; 3 tabs

  15. Sensitivity of the PEP beam transport line to perturbations

    International Nuclear Information System (INIS)

    Peterson, J.M.; Brown, K.L.

    1979-03-01

    The sensitivity of a beam-transport line to various perturbations determines the extent to which one can simplify component design and relax tolerances. For the PEP injection lines, effects of various fabrication errors, magnet misalignments, and residual gas scattering were studied. Using the TURTLE ray-tracing program, it is found that magnetic-field errors corresponding to a relative sextupole strength in the dipoles of 0.5% and/or a relative sextupole or octupole strength in the quadrupoles of 5% are permissible. This allows relatively loose tolerances in magnet fabrication. Transverse misalignment of a quadrupole by a distance x causes the beam centroid to be displaced downstream by as much as 5x. This requires a quadrupole alignment accuracy of +- 0.5 mm or better. No compensation for the earth's field is necessary because an integral number of optical wavelengths and a short wavelength were used for the design. Analysis shows that beam broadening from multiple coulomb scattering is insignificant for pressures of less than 1/10 torr

  16. Experimental Program for the CLIC test facility 3 test beam line

    CERN Document Server

    Adli, E; Dobert, S; Olvegaard, M; Schulte, D; Syratchev, I; Lillestol, Reidar

    2010-01-01

    The CLIC Test Facility 3 Test Beam Line is the first prototype for the CLIC drive beam decelerator. Stable transport of the drive beam under deceleration is a mandatory component in the CLIC two-beam scheme. In the Test Beam Line more than 50% of the total energy will be extracted from a 150 MeV, 28 A electron drive beam, by the use of 16 power extraction and transfer structures. A number of experiments are foreseen to investigate the drive beam characteristics under deceleration in the Test Beam Line, including beam stability, beam blow up and the efficiency of the power extraction. General benchmarking of decelerator simulation and theory studies will also be performed. Specially designed instrumentation including precision BPMs, loss monitors and a time-resolved spectrometer dump will be used for the experiments. This paper describes the experimental program foreseen for the Test Beam Line, including the relevance of the results for the CLIC decelerator studies.

  17. The synchrotron and its related technology for ion beam therapy

    International Nuclear Information System (INIS)

    Hiramoto, Kazuo; Umezawa, Masumi; Saito, Kazuyoshi; Tootake, Satoshi; Nishiuchi, Hideaki; Hara, Shigemistu; Tanaka, Masanobu; Matsuda, Koji; Sakurabata, Hiroaki; Moriyama, Kunio

    2007-01-01

    Hitachi has developed several new technologies for the synchrotron and its related system to realize reliable and flexible operation of a proton therapy system. Especially important among them are a non-resonant RF acceleration cavity using FINEMET core with multiple power feeding and radio frequency driven beam extraction technique (RF-DE) for a synchrotron. Various treatment operations such as variable acceleration energy or respiration gating became possible and simple due to the above technique. For beam transport, a beam steering method for the beam, using transfer matrix realizes quick and precise correction of the beam orbit. A compact microwave ion source has also been developed for the injector to obtain further higher reliability and availability. Most of these technologies are also effective to enhance the reliability and flexibility of other ion beam therapy systems

  18. Issues for Bringing Electron Beam Irradiators On-Line

    International Nuclear Information System (INIS)

    Kaye, R.J.; Turman, B.N.

    1999-01-01

    Irradiation of red meat and poultry has been approved by the U.S. FDA, and the U.S. Department of Agriculture's rule for processing red meat is out for comment. Looking beyond the current issues of packaging materials, labeling, and consumer acceptance, this paper reviews the next step of implementation and how to remove, or at least reduce, the barriers to utilization. Polls of the user community identified their requirements for electron beam or x-ray processing of meat or poultry and their concerns about implementation for on-line processing. These needs and issues are compared to the capabilities of the accelerator industry. The critical issues of beam utilization and dose uniformity, factors affecting floor space requirements, and treatment costs are examined

  19. Beam Line VI REC-steel hybrid wiggler for SSRL

    International Nuclear Information System (INIS)

    Hoyer, E.; Chan, T.; Chin, J.W.G.; Halbach, K.; Kim, K.J.; Winick, H.; Yang, J.

    1983-03-01

    A wiggler magnet with 27 periods, each 7 cm long which reaches 1.21 T at a 1.2 cm gap and 1.64 T at 0.8 cm gap has been designed and is in fabrication. Installation in SPEAR is scheduled for mid 1983. This new wiggler will be the radiation source for a new high intensity synchrotron radiation beam line at SSRL. The magnet utilizes rare-earth cobalt (REC) material and steel in a hybrid configuration to achieve simultaneously a high magnetic field with a short period. The magnet is external to a thin walled variable gap stainless steel vacuum chamber which is opened to provide beam aperture of 1.8 cm gap at injection and then closed to a smaller aperture (< 1.0 cm). Five independent drive systems are provided to adjust the magnet and chamber gaps and alignment. Magnetic design, construction details and magnetic measurements are presented

  20. Beam profile monitor system for the bevalac transfer line

    International Nuclear Information System (INIS)

    Stover, G.

    1985-01-01

    Incorporated in the current Bevalac transfer line upgrade project is a proposal for a new electronic beam monitoring system. It will be designed to amplify, convert, and transmit the signals of twelve 16 by 16 multi-wire grids to a central computer located in the Bevatron control room. Each station will contain interface amplifiers and a local microprocessor to convert wire grid currents into digitized values which will then be transmitted via a serial data channel to the main computer. The system will have a large dynamic range (1 nano to 1 milli-ampere of beam current), be designed for distributed operation, and will be easily expandable. This paper describes the basic electronic hardware and software components of the proposed system

  1. Issues for Bringing Electron Beam Irradiators On-Line

    Energy Technology Data Exchange (ETDEWEB)

    Kaye, R.J.; Turman, B.N.

    1999-04-20

    Irradiation of red meat and poultry has been approved by the U.S. FDA, and the U.S. Department of Agriculture's rule for processing red meat is out for comment. Looking beyond the current issues of packaging materials, labeling, and consumer acceptance, this paper reviews the next step of implementation and how to remove, or at least reduce, the barriers to utilization. Polls of the user community identified their requirements for electron beam or x-ray processing of meat or poultry and their concerns about implementation for on-line processing. These needs and issues are compared to the capabilities of the accelerator industry. The critical issues of beam utilization and dose uniformity, factors affecting floor space requirements, and treatment costs are examined.

  2. Review of ion beam therapy: Present and Future

    International Nuclear Information System (INIS)

    Alonso, Jose R.

    2000-01-01

    First therapy efforts at the Bevalac using neon ions took place in the 70's and 80's. Promising results led to construction of HIMAC in Chiba Japan, and more recently to therapy trials at GSI. Both these facilities are now treating patients with carbon beams. Advances in both accelerator technology and beam delivery have taken place at these two centers. Plans are well along for new facilities in Europe and Japan

  3. Accuracy of robotic patient positioners used in ion beam therapy

    International Nuclear Information System (INIS)

    Nairz, Olaf; Winter, Marcus; Heeg, Peter; Jäkel, Oliver

    2013-01-01

    In this study we investigate the accuracy of industrial six axes robots employed for patient positioning at the Heidelberg Ion Beam Therapy Center. In total 1018 patient setups were monitored with a laser tracker and subsequently analyzed. The measurements were performed in the two rooms with a fixed horizontal beam line. Both, the 3d translational errors and the rotational errors around the three table axes were determined. For the first room the 3d error was smaller than 0.72 mm in 95 percent of all setups. The standard deviation of the rotational errors was at most 0.026° for all axes. For the second room Siemens implemented an improved approach strategy to the final couch positions. The 95 percent quantile of the 3d error could in this room be reduced to 0.53 mm; the standard deviation of the rotational errors was also at most 0.026°. Robots are very flexible tools for patient positioning in six degrees of freedom. This study proved that the robots are able to achieve clinically acceptable accuracy in real patient setups, too

  4. Design of Database System of HIRFL-CSR Beam Line

    International Nuclear Information System (INIS)

    Li Peng; Li Ke; Yin Dayu; Yuan Youjin; Gou Shizhe

    2009-01-01

    This paper introduces the database design and optimization for the power supply system of Lanzhou Heavy Ion Accelerator CSR (HIRFL-CSR) beam line. Based on HIFEL-CSR main Oracle database system, the interface was designed to read parameters of the power supply while achieving real-time monitoring. A new database system to store the history data of power supplies was established at the same time, and it realized the data exchange between Oracle database system and Access database system. Meanwhile, the interface was designed conveniently for printing and query parameters. (authors)

  5. Radiotherapy for ocular lesions by electron beam therapy

    International Nuclear Information System (INIS)

    Miyaishi, Kazuo

    1981-01-01

    Radiotherapy can be very significant as the treatment for ocular lesions, eyes need to be preserved as properly as possible on their functions and cosmetics. The appliance of conventional X ray therapy has been gradually abandaned as conventional X ray therapy ceased to be accepted as the general treatment for malignant tumors. Consequently the necessity of electron beam therapy has been rising even as the substituted method for conventional X ray therapy. The department of radiology of Gunma University was obliged to establish a new therapy for ocular lesions, and has been trying electron beam therapy since 1973; It is concluded that electron beam therapy is not at all inferior to conventional X ray therapy as reported above. Basic therapeutic methods for ocular lesions are the following: 1) For epidermoid carcinoma, 600 rads at a time, 3600 - 4200 rads in total is applied by 8 MeV electron twice a week method. 2) For malignant melanoma, 1000 rads at a time, 4000 - 5000 rads in total is applied by 8 MeV electron twice a week method. 3) For orbitar lymphoid neoplasm, Cobalt-60 γ ray or Linac X ray is applied together with electron beam. 4) For embryonal rhabdomyosarcoma, adenoid cystic cancer etc., the therapy for whole body is necessary. 5) For benign tumors, a small dose at a time is applied for a long time. (author)

  6. Neutron capture therapy beams at the MIT Research Reactor

    International Nuclear Information System (INIS)

    Choi, J.R.; Clement, S.D.; Harling, O.K.; Zamenhof, R.G.

    1990-01-01

    Several neutron beams that could be used for neutron capture therapy at MITR-II are dosimetrically characterized and their suitability for the treatment of glioblastoma multiforme and other types of tumors are described. The types of neutron beams studied are: (1) those filtered by various thicknesses of cadmium, D2O, 6Li, and bismuth; and (2) epithermal beams achieved by filtration with aluminum, sulfur, cadmium, 6Li, and bismuth. Measured dose vs. depth data are presented in polyethylene phantom with references to what can be expected in brain. The results indicate that both types of neutron beams are useful for neutron capture therapy. The first type of neutron beams have good therapeutic advantage depths (approximately 5 cm) and excellent in-phantom ratios of therapeutic dose to background dose. Such beams would be useful for treating tumors located at relatively shallow depths in the brain. On the other hand, the second type of neutron beams have superior therapeutic advantage depths (greater than 6 cm) and good in-phantom therapeutic advantage ratios. Such beams, when used along with bilateral irradiation schemes, would be able to treat tumors at any depth in the brain. Numerical examples of what could be achieved with these beams, using RBEs, fractionated-dose delivery, unilateral, and bilateral irradiation are presented in the paper. Finally, additional plans for further neutron beam development at MITR-II are discussed

  7. A proton beam delivery system for conformal therapy and intensity modulated therapy

    International Nuclear Information System (INIS)

    Yu Qingchang

    2001-01-01

    A scattering proton beam delivery system for conformal therapy and intensity modulated therapy is described. The beam is laterally spread out by a dual-ring double scattering system and collimated by a program-controlled multileaf collimator and patient specific fixed collimators. The proton range is adjusted and modulated by a program controlled binary filter and ridge filters

  8. Requirements and guidelines for NSLS experimental beam line vacuum systems: Revision A

    International Nuclear Information System (INIS)

    Foerster, C.; Halama, H.; Thomlinson, W.

    1986-10-01

    Requirements are provided for NSLS beam line front ends and vacuum interlocks. Guidelines are provided for UHV beam line vacuum systems, including materials, vacuum hardware (pumps, valves, and flanges), acoustic delay lines and beam line fast valves, instrumentation, fabrication and testing, and the NSLS cleaning facility. Also discussed are the design review for experimenters' equipment that would be connected to the NSLS and acceptance tests for any beam line to be connected with the ring vacuum. Also appended are a description of the acoustic delay line as well as the NSLS vacuum standards and NSLS procedures

  9. Development of BPM/BLM DAQ System for KOMAC Beam Line

    Energy Technology Data Exchange (ETDEWEB)

    Song, Young-Gi; Kim, Jae-Ha; Yun, Sang-Pil; Kim, Han-Sung; Kwon, Hyeok-Jung; Cho, Yong-Sub [Korea Atomic Energy Research Institute, Gyeongju (Korea, Republic of)

    2016-10-15

    The proton beam is accelerated from 3 MeV to 100 MeV through 11 DTL tanks. The KOMAC installed 10 beam lines, 5 for 20-MeV beams and 5 for 100-MeV beams. The proton beam is transmitted to two target room. The KOMAC has been operating two beam lines, one for 20 MeV and one for 100 MeV. New beam line, RI beam line is under commissioning. A Data Acquisition (DAQ) system is essential to monitor beam signals in an analog front-end circuitry from BPM and BLM at beam lines. A data acquisition (DAQ) system is essential to monitor beam signals in an analog front-end circuitry from BPM and BLM at beam lines. The DAQ digitizes beam signal and the sampling is synchronized with a reference signal which is an external trigger for beam operation. The digitized data is accessible by the Experimental Physics and Industrial Control System (EPICS)-based control system, which manages the whole accelerator control. The beam monitoring system integrates BLM and BPM signals into the control system and offers realtime data to operators. The IOC, which is implemented with Linux and a PCI driver, supports data acquisition as a very flexible solution.

  10. RFQ Cooler and Buncher (and beam line section associated)

    CERN Document Server

    Podadera-Aliseda, I

    2003-01-01

    Developing a new RFQ cooler and buncher for ISOLDE. Such a device combines an energy loss in buffer gas atom-ion collisions with confinement provided by RF-field in transverse plane. Optional confinement in longitudinal direction is provided by static potential dwell. Then, an improvement of the beam line is achieved for all the experiments at ISOLDE. The RFQ operates inside a high voltage cage of 60 kV, and with a system of turbomulecular pumps both to keep the high vacuum before/after the RFQ and to keep a low pressure (around 0,1 mbar) inside the RFQ. The project is to be thought not only as a mechanical design and construction project, unless as a project of research and development, since it is about improving (operationally and technically) the existing RFQ cooler and buncher placed around the world. Due to ion optical reasons whole beam line section has to be redesigned and constructed as a part of this project.

  11. Beam-optics study of the gantry beam delivery system for light-ion cancer therapy

    International Nuclear Information System (INIS)

    Pavlovic, M.

    1995-12-01

    Ion optics considerations on the granty-like beam delivery system for light-ion cancer therapy are presented. A low-angle active beam scanning in two directions is included in the preliminary gantry design. The optical properties of several gantry modifications are discussed. (orig.)

  12. A beam monitor using silicon pixel sensors for hadron therapy

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhen, E-mail: zwang@mails.ccnu.edu.cn; Zou, Shuguang; Fan, Yan; Liu, Jun; Sun, Xiangming, E-mail: sphy2007@126.com; Wang, Dong; Kang, Huili; Sun, Daming; Yang, Ping; Pei, Hua; Huang, Guangming; Xu, Nu; Gao, Chaosong; Xiao, Le

    2017-03-21

    We report the design and test results of a beam monitor developed for online monitoring in hadron therapy. The beam monitor uses eight silicon pixel sensors, Topmetal-II{sup -}, as the anode array. Topmetal-II{sup -} is a charge sensor designed in a CMOS 0.35 µm technology. Each Topmetal-II{sup -} sensor has 72×72 pixels and the pixel size is 83×83 µm{sup 2}. In our design, the beam passes through the beam monitor without hitting the electrodes, making the beam monitor especially suitable for monitoring heavy ion beams. This design also reduces radiation damage to the beam monitor itself. The beam monitor is tested with a carbon ion beam at the Heavy Ion Research Facility in Lanzhou (HIRFL). Results indicate that the beam monitor can measure position, incidence angle and intensity of the beam with a position resolution better than 20 µm, angular resolution about 0.5° and intensity statistical accuracy better than 2%.

  13. An Energy-Stabilized Varied-Line-Space-Monochromator Undulator Beam Line for PEEM Illumination and Magnetic Circular Dichroism

    International Nuclear Information System (INIS)

    Warwick, Tony; McKinney, Wayne; Domning, Ed; Doran, Andrew; Padmore, Howard

    2006-01-01

    A new undulator beam line has been built and commissioned at the Advanced Light Source for illumination of the PEEM3 microscope. The beam line delivers high flux beams over an energy range from C1s through the transition metals to include the M edges of the magnetic rare earth elements. We present details of the optical design, and data on the performance of the zero-order tracking of the photon energy

  14. Construction of Superconducting Magnet System for the J-PARC Neutrino Beam Line

    Energy Technology Data Exchange (ETDEWEB)

    Nakamoto, T.; Wanderer, P.; Sasaki, K.; Ajima, Y.; Araoka, O.; Fujii, Y.; Hastings, N.; Higashi, N.; Iida, M.; Ishii, T.; Kimura, N.; Kobayashi, T.; Makida, Y.; Nakadaira, T.; Ogitsu, T.; Ohhata, H.; Okamura, T.; Sakashita, K.; Sugawara, S.; Suzuki, S.; Tanaka, K.; Tomaru, T.; Terashima, A.; Yamamoto, A.; Ichikawa, A.; Kakuno, H.; Anerella, M.; Escallier, J.; Ganetis, G.; gupta, R.; Jain, A.; Muratore, J.; Parker, B.; Boussuge, T.; Charrier, J.-P.; Arakawa, M.; Ichihara, T.; Minato, T.; Okada, Y.; Itou, A.; Kumaki, T.; Nagami, M.; Takahashi, T.

    2009-10-18

    Following success of a prototype R&D, construction of a superconducting magnet system for J-PARC neutrino beam line has been carried out since 2005. A new conceptual beam line with the superconducting combined function magnets demonstrated the successful beam transport to the neutrino production target.

  15. Operating instructions for ORELA [Oak Ridge Electron Linear Accelerator] positron beam line

    International Nuclear Information System (INIS)

    Donohue, D.L.; Hulett, L.D. Jr.; Lewis, T.A.

    1990-11-01

    This report will contain details of the construction and operation of the positron beam line. Special procedures which are performed on a less frequent basis will also be described. Appendices will contain operating instructions for experiments which make use of the positron beam and are connected to the beam line. Finally, a review of safety-related considerations will be presented

  16. The expert system OPTRAN (Ver 1.0) and its application to beam transportation line design

    International Nuclear Information System (INIS)

    Xiao Meiqin; Lu Hongyou; Fan Mingwu

    1994-01-01

    The expert system OPTRAN (Ver 1.0) used for beam transportation line design is introduced. The knowledge storage and reasoning principle, of which the intelligence part of OPTRAN are composed, have been described in detail. By using OPTRAN (Ver 1.0), the design of a beam transportation line for extracted ion beam of Cyclone 30 was completed

  17. Measurements and simulations of focused beam for orthovoltage therapy

    International Nuclear Information System (INIS)

    Abbas, Hassan; Mahato, Dip N.; Satti, Jahangir; MacDonald, C. A.

    2014-01-01

    Purpose: Megavoltage photon beams are typically used for therapy because of their skin-sparing effect. However, a focused low-energy x-ray beam would also be skin sparing, and would have a higher dose concentration at the focal spot. Such a beam can be produced with polycapillary optics. MCNP5 was used to model dose profiles for a scanned focused beam, using measured beam parameters. The potential of low energy focused x-ray beams for radiation therapy was assessed. Methods: A polycapillary optic was used to focus the x-ray beam from a tungsten source. The optic was characterized and measurements were performed at 50 kV. PMMA blocks of varying thicknesses were placed between optic and the focal spot to observe any variation in the focusing of the beam after passing through the tissue-equivalent material. The measured energy spectrum was used to model the focused beam in MCNP5. A source card (SDEF) in MCNP5 was used to simulate the converging x-ray beam. Dose calculations were performed inside a breast tissue phantom. Results: The measured focal spot size for the polycapillary optic was 0.2 mm with a depth of field of 5 mm. The measured focal spot remained unchanged through 40 mm of phantom thickness. The calculated depth dose curve inside the breast tissue showed a dose peak several centimeters below the skin with a sharp dose fall off around the focus. The percent dose falls below 10% within 5 mm of the focus. It was shown that rotating the optic during scanning would preserve the skin-sparing effect of the focused beam. Conclusions: Low energy focused x-ray beams could be used to irradiate tumors inside soft tissue within 5 cm of the surface

  18. Beam monitoring in radiotherapy and hadron-therapy

    International Nuclear Information System (INIS)

    Fontbonne, J.M.

    2012-01-01

    Radiotherapy techniques have evolved over the past twenty years. For photon beams, the development of tools such as multi leaf collimators, machines such as Cyberknife or tomo-therapy, have improved the conformation of treatments to the tumor volume and lowered maximum dose to healthy tissue. In another register, the use of proton-therapy is expanding in all countries and the development of carbon ions beams for hadron-therapy is also increasing. If techniques improve, the control requirements for the monitoring of the dose administered to patients are always the same. This document presents, first, the ins and outs of the different techniques of external beam radiotherapy: photon treatments, protons and hadrons. Starting from the basis of clinical requirements, it sets the variables to be measured in order to ensure the quality of treatment for the different considered modalities. It then describes some implementations, based on precise and rigorous specifications, for the monitoring and measurement of beams delivered by external beam radiotherapy equipments. Two instrumental techniques are particularly highlighted, plastic scintillators dosimetry for the control of megavoltage photon beams and ionization chamber dosimetry applied to proton-therapy or radiobiology experiments conducted at the GANIL facility. Analyzes and perspectives, based on the recent developments of treatment techniques, are delivered in conclusion and can serve as guide for future instrumental developments. (author)

  19. Computer controlled vacuum control system for synchrotron radiation beam lines

    International Nuclear Information System (INIS)

    Goldberg, S.M.; Wang, C.; Yang, J.

    1983-01-01

    The increasing number and complexity of vacuum control systems at the Stanford Synchrotron Radiation Laboratory has resulted in the need to computerize its operations in order to lower costs and increase efficiency of operation. Status signals are transmitted through digital and analog serial data links which use microprocessors to monitor vacuum status continuously. Each microprocessor has a unique address and up to 256 can be connected to the host computer over a single RS232 data line. A FORTRAN program on the host computer will request status messages and send control messages via only one RS232 line per beam line, signal the operator when a fault condition occurs, take automatic corrective actions, warn of impending valve failure, and keep a running log of all changes in vacuum status for later recall. Wiring costs are thus greatly reduced and more status conditions can be monitored without adding excessively to the complexity of the system. Operators can then obtain status reports at various locations in the lab quickly without having to read a large number of meter and LED's

  20. submitter Parametric study of transport beam lines for electron beams accelerated by laser-plasma interaction

    CERN Document Server

    Scisciò, M; Migliorati, M; Mostacci, A; Palumbo, L; Papaphilippou, Y; Antici, P

    2016-01-01

    In the last decade, laser-plasma acceleration of high-energy electrons has attracted strong attention in different fields. Electrons with maximum energies in the GeV range can be laser-accelerated within a few cm using multi-hundreds terawatt (TW) lasers, yielding to very high beam currents at the source (electron bunches with up to tens-hundreds of pC in a few fs). While initially the challenge was to increase the maximum achievable electron energy, today strong effort is put in the control and usability of these laser-generated beams that still lack of some features in order to be used for applications where currently conventional, radio-frequency (RF) based, electron beam lines represent the most common and efficient solution. Several improvements have been suggested for this purpose, some of them acting directly on the plasma source, some using beam shaping tools located downstream. Concerning the latter, several studies have suggested the use of conventional accelerator magnetic devices (such as quadrupo...

  1. Study on external beam radiation therapy

    International Nuclear Information System (INIS)

    Kim, Mi Sook; Yoo, Seoung Yul; Yoo, Hyung Jun; Ji, Young Hoon; Lee, Dong Han; Lee, Dong Hoon; Choi, Mun Sik; Yoo, Dae Heon; Lee, Hyo Nam; Kim, Kyeoung Jung

    1999-04-01

    To develop the therapy technique which promote accuracy and convenience in external radiation therapy, to obtain the development of clinical treatment methods for the global competition. The contents of the R and D were 1. structure, process and outcome analysis in radiation therapy department. 2. Development of multimodality treatment in radiation therapy 3. Development of computation using networking techniques 4. Development of quality assurance (QA) system in radiation therapy 5. Development of radiotherapy tools 6. Development of intraoperative radiation therapy (IORT) tools. The results of the R and D were 1. completion of survey and analysis about Korea radiation therapy status 2. Performing QA analysis about ICR on cervix cancer 3. Trial of multicenter randomized study on lung cancers 4. Setting up inter-departmental LAN using MS NT server and Notes program 5. Development of ionization chamber and dose-rate meter for QA in linear accelerator 6. Development on optimized radiation distribution algorithm for multiple slice 7. Implementation on 3 dimensional volume surface algorithm and 8. Implementation on adaptor and cone for IORT

  2. Study on external beam radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Mi Sook; Yoo, Seoung Yul; Yoo, Hyung Jun; Ji, Young Hoon; Lee, Dong Han; Lee, Dong Hoon; Choi, Mun Sik; Yoo, Dae Heon; Lee, Hyo Nam; Kim, Kyeoung Jung

    1999-04-01

    To develop the therapy technique which promote accuracy and convenience in external radiation therapy, to obtain the development of clinical treatment methods for the global competition. The contents of the R and D were 1. structure, process and outcome analysis in radiation therapy department. 2. Development of multimodality treatment in radiation therapy 3. Development of computation using networking techniques 4. Development of quality assurance (QA) system in radiation therapy 5. Development of radiotherapy tools 6. Development of intraoperative radiation therapy (IORT) tools. The results of the R and D were 1. completion of survey and analysis about Korea radiation therapy status 2. Performing QA analysis about ICR on cervix cancer 3. Trial of multicenter randomized study on lung cancers 4. Setting up inter-departmental LAN using MS NT server and Notes program 5. Development of ionization chamber and dose-rate meter for QA in linear accelerator 6. Development on optimized radiation distribution algorithm for multiple slice 7. Implementation on 3 dimensional volume surface algorithm and 8. Implementation on adaptor and cone for IORT.

  3. Radiation dermatitis following electron beam therapy

    International Nuclear Information System (INIS)

    Price, N.M.

    1978-01-01

    Ten patients, who had been treated for mycosis fungoides with electron beam radiation ten or more years previously, were examined for signs of radiation dermatitis. Although most patients had had acute radiation dermatitis, only a few manifested signs of mild chronic changes after having received between 1,000 and 2,800 rads

  4. Treatment Planning for Ion Beam Therapy

    Science.gov (United States)

    Jäkel, Oliver

    The special aspects of treatment planning for ion beams are outlined in this chapter, starting with positioning and immobilization of the patient, describing imaging and segmentation, definition of treatment parameters, dose calculation and optimization, and, finally, plan assessment, verification, and quality assurance.

  5. Grasshopper beam line for utilization of synchrotron radiation

    International Nuclear Information System (INIS)

    Saito, Norio; Suzuki, I.H.; Onuki, Hideo; Nishi, Morotake

    1989-01-01

    Optical characteristics of a new beam line consisting of a pre-mirror, a Grasshopper monochromator and a re-focusing mirror have been investigated. A ray-tracing calculation was performed for designing the mirrors so as to optimize the photon intensity and the spot size at the sample point. The intensity of the monochromatic soft x-ray was about 10 8 photons/(sec·100mA) at 25 A under the storage electron energy of 600 MeV with the minimum slit width which corresponded to a resolution of about 500. The sum of stray light and higher order components was less than 10% of the total intensity except around the C-K edge. Using an appropriate filter, it was reduced to less than a few percent. (author)

  6. Report of the accelerator and beam line options working group

    International Nuclear Information System (INIS)

    Ankenbrandt, C.; Bogacz, A.; Bogert, D.; Bossert, R.C.; Brown, B.; Childress, S.; Crawford, C.; Dugan, G.; Even, L.; Finley, D.; Gelfand, N.; Gerig, R.; Goderre, G.; Gourlay, S.; Griffin, J.; Hahn, A.; Holmes, S.; Jackson, G.; Johnson, R.; Johnson, D.; Kerby, J.; Koepke, K.; Koizumi, G.; Koul, R.; Lamm, M.; MacLachlan, J.; Malamud, E.; Malensek, A.; Mantsch, P.; Marriner, J.; Marsh, B.; Martin, P.; Hills, F.; Moore, C.; Murphy, T.; Nicol, T.; Peterson, T.; Pruss, S.; Rameika, G.; Riddiford, A.; Rosenzweig, J.; Russell, A.; Saritepe, S.; Stahl, S.; Strait, J.; Trbojevic, D.; Visnjic, V.; Volk, J.; Johnson, D.; Syphers, M.; Mohl, D.; Ruggiero, S.; Collins, T.

    1990-01-01

    This report summarizes work done before, during, and after the conference. The group was broken down into six subgroups. Subgroup 1 considered collider aspects of the phase 1 and phase 2 upgrade plans. Also considered were the collider aspects of a specific example of Phase 3, namely the replacement of the Tevatron with a new ring providing 1.8 TeV per beam. Subgroup 2 considered specific improvements to the proposed Main Injector (MI) which will enhance the performance of Phase 2. Also considered were improvements which may be made to the present Main Ring (MR) which will enchance performance of Phase 1. Subgroup 3 considered fixed target aspects of the Phase 1 and 2 upgrade plans and a specific example of Phase 3, namely the replacement of the Tevatron with a new ring providing 1.5 TeV fixed target operation. Subgroup 4 considered the external beam lines associated with the upgrades. Subgroup 5 considered the new designs of the superconducting magnets and associated large cryogenic systems connected with the accelerator systems proposed by the other groups. Subgroup 6 assumed the existence of Phase 1 and 2 upgrades and considered new possibilities for Phase 3 such as new accelerators in new tunnels

  7. Overview of Light-Ion Beam Therapy

    International Nuclear Information System (INIS)

    Chu, William T.

    2006-01-01

    compared to those in conventional (photon) treatments. Wilson wrote his personal account of this pioneering work in 1997. In 1954 Cornelius Tobias and John Lawrence at the Radiation Laboratory (former E.O. Lawrence Berkeley National Laboratory) of the University of California, Berkeley performed the first therapeutic exposure of human patients to hadron (deuteron and helium ion) beams at the 184-Inch Synchrocyclotron. By 1984, or 30 years after the first proton treatment at Berkeley, programs of proton radiation treatments had opened at: University of Uppsala, Sweden, 1957; the Massachusetts General Hospital-Harvard Cyclotron Laboratory (MGH/HCL), USA, 1961; Dubna (1967), Moscow (1969) and St Petersburg (1975) in Russia; Chiba (1979) and Tsukuba (1983) in Japan; and Villigen, Switzerland, 1984. These centers used the accelerators originally constructed for nuclear physics research. The experience at these centers has confirmed the efficacy of protons and light ions in increasing the tumor dose relative to normal tissue dose, with significant improvements in local control and patient survival for several tumor sites. M.R. Raju reviewed the early clinical studies. In 1990, the Loma Linda University Medical Center in California heralded in the age of dedicated medical accelerators when it commissioned its proton therapy facility with a 250-MeV synchrotron. Since then there has been a relatively rapid increase in the number of hospital-based proton treatment centers around the world, and by 2006 there are more than a dozen commercially-built facilities in use, five new facilities under construction, and more in planning stages. In the 1950s larger synchrotrons were built in the GeV region at Brookhaven (3-GeV Cosmotron) and at Berkeley (6-GeV Bevatron), and today most of the world's largest accelerators are synchrotrons. With advances in accelerator design in the early 1970s, synchrotrons at Berkeley and Princeton accelerated ions with atomic numbers between 6 and 18, at

  8. Overview of Light-Ion Beam Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Chu, William T.

    2006-03-16

    treatment volume compared to those in conventional (photon) treatments. Wilson wrote his personal account of this pioneering work in 1997. In 1954 Cornelius Tobias and John Lawrence at the Radiation Laboratory (former E.O. Lawrence Berkeley National Laboratory) of the University of California, Berkeley performed the first therapeutic exposure of human patients to hadron (deuteron and helium ion) beams at the 184-Inch Synchrocyclotron. By 1984, or 30 years after the first proton treatment at Berkeley, programs of proton radiation treatments had opened at: University of Uppsala, Sweden, 1957; the Massachusetts General Hospital-Harvard Cyclotron Laboratory (MGH/HCL), USA, 1961; Dubna (1967), Moscow (1969) and St Petersburg (1975) in Russia; Chiba (1979) and Tsukuba (1983) in Japan; and Villigen, Switzerland, 1984. These centers used the accelerators originally constructed for nuclear physics research. The experience at these centers has confirmed the efficacy of protons and light ions in increasing the tumor dose relative to normal tissue dose, with significant improvements in local control and patient survival for several tumor sites. M.R. Raju reviewed the early clinical studies. In 1990, the Loma Linda University Medical Center in California heralded in the age of dedicated medical accelerators when it commissioned its proton therapy facility with a 250-MeV synchrotron. Since then there has been a relatively rapid increase in the number of hospital-based proton treatment centers around the world, and by 2006 there are more than a dozen commercially-built facilities in use, five new facilities under construction, and more in planning stages. In the 1950s larger synchrotrons were built in the GeV region at Brookhaven (3-GeV Cosmotron) and at Berkeley (6-GeV Bevatron), and today most of the world's largest accelerators are synchrotrons. With advances in accelerator design in the early 1970s, synchrotrons at Berkeley and Princeton accelerated ions with atomic numbers

  9. Design and Status of the ELIMED Beam Line for Laser-Driven Ion Beams

    Directory of Open Access Journals (Sweden)

    G. A. Pablo Cirrone

    2015-08-01

    Full Text Available Charged particle acceleration using ultra-intense and ultra-short laser pulses has gathered a strong interest in the scientific community and it is now one of the most attractive topics in the relativistic laser-plasma interaction research. Indeed, it could represent the future of particle acceleration and open new scenarios in multidisciplinary fields, in particular, medical applications. One of the biggest challenges consists of using, in a future perspective, high intensity laser-target interaction to generate high-energy ions for therapeutic purposes, eventually replacing the old paradigm of acceleration, characterized by huge and complex machines. The peculiarities of laser-driven beams led to develop new strategies and advanced techniques for transport, diagnostics and dosimetry of the accelerated particles, due to the wide energy spread, the angular divergence and the extremely intense pulses. In this framework, the realization of the ELIMED (ELI-Beamlines MEDical applications beamline, developed by INFN-LNS (Catania, Italy and installed in 2017 as a part of the ELIMAIA beamline at the ELI-Beamlines (Extreme Light Infrastructure Beamlines facility in Prague, has the aim to investigate the feasibility of using laser-driven ion beams in multidisciplinary applications. ELIMED will represent the first user’s open transport beam line where a controlled laser-driven ion beam will be used for multidisciplinary and medical studies. In this paper, an overview of the beamline, with a detailed description of the main transport elements, will be presented. Moreover, a description of the detectors dedicated to diagnostics and dosimetry will be reported, with some preliminary results obtained both with accelerator-driven and laser-driven beams.

  10. New magnet transport system for the LHC beam transfer lines

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    The first of 700 magnets has been installed in one of the two transfer tunnels built to transfer the SPS beam into the LHC. The start of this first installation phase of the LHC transfer lines provides the opportunity to launch a new and highly original modular system for transporting and installing all kinds of magnets in very narrow tunnels. The system (pictured here in one of the tunnels) is based on very compact bogies, up to four of which can be coupled together to form a convoy. The wheels are fitted with individual motors enabling them to swivel through an angle of 90° and the convoy to move laterally. The lead vehicle is powered by an electric rail set into the roof of the tunnel. The system is backed up by electrical batteries that enable it to operate in the absence of an outside power source or in the event of power failure. Last but not least, for the long-distance transport of magnets, it can be optically guided by a line traced on the tunnel floor. The convoy moves through the particularly narr...

  11. Cryogenic supplies for the TFTR neutral beam line cryopanels

    International Nuclear Information System (INIS)

    Pinter, G.

    1977-01-01

    Cryocondensing panels will be used for the Neutral Beam Lines of the TFTR to satisfy a pumping speed requirement of 2.5 x 10 6 l/s. The cryocondensing panels are fed by liquid helium (LHe), boiling at selectable temperatures of 4.5 0 K or 3.8 0 K. Liquid nitrogen (LN 2 ) panels and chevrons thermally shield the LHe panel. The closed-loop LHe supply system and the open loop LN 2 system are discussed. The helium refrigerator of minimum 1070-W capacity, together with its distribution system, and the nitrogen distribution system in the ton/hour LN 2 range is presented. Problems and their solutions in connection with the LHe system, including the distribution over a distance of 500 feet of large quantities of liquid/gas mixtures with load variations over the range of about 3 : 1, and the economies of various types of distribution lines (passive, pumped, shielded, combined), are described. The system design passed the preliminary phase. Design features and auxiliary equipment to assure dispersion of large quantities of nitrogen into the atmosphere and to permit operation under degraded cryogenic helium refrigerator performance are also discussed in Design Considerations

  12. Extraction Compression and Acceleration of High Line Charge Density Ion Beams

    CERN Document Server

    Henestroza, Enrique; Grote, D P; Peters, Craig; Yu, Simon

    2005-01-01

    HEDP applications require high line charge density ion beams. An efficient method to obtain this type of beams is to extract a long pulse, high current beam from a gun at high energy, and let the beam pass through a decelerating field to compress it. The low energy beam bunch is loaded into a solenoid and matched to a Brillouin flow. The Brillouin equilibrium is independent of the energy if the relationship between the beam size (a), solenoid magnetic field strength (B) and line charge density is such that (Ba)2

  13. Neutron beam-line shield design for the protein crystallography instrument at the Lujan Center

    International Nuclear Information System (INIS)

    Russell, G.J.; Pitcher, E.J.; Muhrer, G.; Ferguson, P.D.

    2001-01-01

    We have developed a very useful methodology for calculating absolute total (neutron plus gamma-ray) dose equivalent rates for use in the design of neutron beam line shields at a spallation neutron source. We have applied this technique to the design of beam line shields for several new materials science instruments being built at the Manuel Lujan Jr. Neutron Scattering Center. These instruments have a variety of collimation systems and different beam line shielding issues. We show here some specific beam line shield designs for the Protein Crystallography Instrument. (author)

  14. An automatic beam steering system for the NSLS X-17T beam line using closed orbit feedback

    International Nuclear Information System (INIS)

    Nawrocky, R.J.; Ma, Li; Rarback, H.M.; Singh, O.V.; Yu, L.H.

    1987-01-01

    Initial observations of motion of the undulator radiation in the NSLS X-17T beam line clearly indicated that the beam had to be stabilized in both directions to be usable for the planned soft x-ray imaging experiments. The low frequency spectra of beam motion contained peaks in the range from dc to 60 Hz and at higher frequencies. A beam steering system employing closed orbit feedback has been designed and installed to stabilize the beam in both planes. In each plane of motion, beam position is measured with a beam position detector and a correction signal is fed back to a local four magnet orbit bump to dynamically control the angle of the radiation at the source. This paper describes the design and performance of the beam steering system

  15. Therapy tumor with the heavy ions beam

    International Nuclear Information System (INIS)

    Dang Bingrong; Wei Zengquan; Li Wenjian

    2002-01-01

    As physical characteristic of heavy ions Bragg peak, therapy tumor with heavy ions is becoming advanced technology. So, many countries have developed the technology and used to treat tumor, the societal and economic effects are beneficial to people. The authors show the development, present situation and information of research in world of advanced radiotherapy with heavy ions

  16. Focused ion-beam line profiles: A study of some factors affecting beam broadening

    International Nuclear Information System (INIS)

    Templeton, I.M.; Champion, H.G.

    1995-01-01

    The current--density profile of a focused ion beam (FIB) has a central peak accompanied by broader ''wings'' that, while unimportant in lithographic applications, can lead to unwanted effects during an implantation operation. The origin of the wings, and hence the best way to minimize them, is not clear and needs further study. We have measured the line profiles of several of the ions available in our FIB machine as a function of a number of variables, under ultrahigh vacuum (UHV) conditions. No effects are observed from changes in emission current or deliberate defocusing of the objective lens. There are some changes with beam aperture and/or current, but the biggest differences seem to be associated with a change of source type and hence, possibly, with a change in the source/extractor configuration or in the alloy and the emission process. The wing amplitudes are appreciably lower than many previously observed, and their profiles, at least for the lighter ions studied (Be ++ , Be + , and B + ), are Gaussian rather than exponential. It seems possible that our UHV conditions may have eliminated a scattering mechanism responsible for the larger, exponential wings previously observed. The corresponding beam and rectangle-edge profiles have been calculated. copyright 1995 American Vacuum Society

  17. Getting Ready for Ion-Beam Therapy Research in Austria - Building-up Research in Parallel with a Facility

    International Nuclear Information System (INIS)

    Georg, Dietmar; Knaeusl; Kuess, Peter; Fuchs, Hermann; Poetter, Richard; Schreiner, Thomas

    2015-01-01

    With participation in ion-beam projects funded nationally or by the European Commission (EC), ion-beam research activities were started at the Medical University of Vienna in parallel with the design and construction of the ion-beam center MedAustron in Wiener Neustadt, 50 km from the Austrian capital. The current medical radiation physics research activities that will be presented comprise: (1) Dose calculation and optimization: ion-beam centers focus mostly on proton and carbon-ion therapy. However, there are other ion species with great potential for clinical applications. Helium ions are currently under investigation from a theoretical physics and biology perspective. (2) Image guided and adaptive ion-beam therapy: organ motion and anatomic changes have a severe influence in ion-beam therapy since variations in heterogeneity along the beam path have a significant impact on the particle range. Ongoing research focuses on possibilities to account for temporal variations of the anatomy during radiotherapy. Both during and between fractions also considering temporal variations in tumor biology. Furthermore, research focuses on particle therapy positron emission tomography (PT-PET) verification and the detection of prompt gammas for on-line verification of ion-beam delivery. (3) Basic and applied dosimetry: an end-to-end procedure was designed and successfully tested in both scanned proton and carbon-ion beams, which may also serve as a dosimetric credentialing procedure for clinical trials in the future. (Author)

  18. Magnetically scanned proton therapy beams: rationales and techniques

    International Nuclear Information System (INIS)

    Jones, D.T.L.; Schreuder, A.N.

    2000-01-01

    Perhaps the most important advantages of beam scanning systems for proton therapy in comparison with conventional passive beam spreading systems are: (1) Intensity modulation and inverse planning are possible. (2) There is negligible reduction in the range of the beam. (3) Integral dose is reduced as dose conformation to the proximal edge of the lesion is possible. (4) In principle no field-specific modifying devices are required. (5) There is less activation of the surroundings. (6) Scanning systems axe almost infinitely flexible. The main disadvantages include: (1) Scanning systems are more complicated and therefore potentially less reliable and more dangerous. (2) The development of such systems is more demanding in terms of cost, time and manpower. (3) More stable beams are required. (4) Dose and beam position monitoring are more difficult. (5) The problems associated with patient and organ movement axe more severe. There are several techniques which can be used for scanning. For lateral beam spreading, circular scanning (wobbling) or linear scanning can be done. In the latter case the beam can be scanned continuously or in a discrete fashion (spot scanning). Another possibility is to undertake the fastest scan in one dimension (strip scanning) and translate the patient or the scanning magnet in the other dimension. Depth variation is achieved by interposing degraders in the beam (cyclotrons) or by changing the beam energy (synchrotrons). The aim of beam scanning is to deliver a predetermined dose at any point in the body. Special safety precautions must be taken because of the high instantaneous dose rates. The beam position and the dose delivered at each point must be accurately and redundantly determined. (author)

  19. Designing of the Low Energy Beam Lines with Achromatic Condition in the RAON Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Hyunchang; Jang, Ji-Ho; Jeon, Dong-O [Institute for Basic Science, Daejeon (Korea, Republic of)

    2017-01-15

    The RAON accelerator has been built to create and accelerate stable heavy-ion beams and rare isotope beams. The stable heavy-ion beams are generated by the superconducting electron cyclotron resonance ion source and accelerated by the low energy superconducting linac SCL1. The beams accelerated by the SCL1 are re-accelerated by the high energy superconducting linac SCL2 for the generation of rare isotope beams by using the in-flight fragmentation system or are put to use in the low energy experimental halls, which include the neutron science facility and the Korea Broad acceptance Recoil spectrometer and Apparatus after having passed through the low energy beam lines which have long deflecting sections. At the end of each beam line in the low energy experimental halls, the beams should meet the targets of the two facilities with the specific requirements satisfied. Namely, if the beam is to be sent safely and accurately to the targets and simultaneously, satisfy the requirements, an achromatic lattice design needs to be applied in each beam line. In this paper, we will present the lattice design of the low energy beam lines and describe the results of the beam dynamics simulations. In addition, the correction of the beam orbit, which is distorted by machine imperfections, will be discussed.

  20. Clinical application of dosimetry in electron beam therapy

    International Nuclear Information System (INIS)

    Yoshiura, Takao

    1995-01-01

    In everyday radiotherapy we must carry out the determination of absorbed dose measurement according to JARP's protocol. We explained an outline of JARP's 1974 and 1986 protocol in electron beam therapy, and mentioned it about the matter that should examined. To use it easily in clinic, a simplified procedure based on precisely to JARP's 1986 protocol is practical, the character of this procedure settles briefly the determination of mean incident energy of electron beams and get ready to table of ionization to absorbed dose conversion factor for various ionization chamber. Also, this procedure almost not influence on the accuracy of determination. We described systematically practical procedure for requisite absorbed dose calculation in a patient in electron beam therapy. (author)

  1. Implant therapy in the esthetic zone: smile line assessment.

    Science.gov (United States)

    Kourkouta, Stella

    2011-04-01

    Assessment of the smile or lip line is imperative when implant therapy is carried out in the esthetic zone. The smile is generally defined as high, average, or low. Females are reported to have higher lip lines than males, which means that they are at greater risk when placing and restoring implants in the esthetic zone. Maximum upper lip elevation, usually observed during a strained posed smile, should be assessed. This paper discusses some clinical observations and concepts in relation to smile line assessment for implant therapy in the esthetic zone. (Int J Periodontics Restorative Dent 2011;31:195-201.).

  2. A Monte Carlo code for ion beam therapy

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    Initially developed for applications in detector and accelerator physics, the modern Fluka Monte Carlo code is now used in many different areas of nuclear science. Over the last 25 years, the code has evolved to include new features, such as ion beam simulations. Given the growing use of these beams in cancer treatment, Fluka simulations are being used to design treatment plans in several hadron-therapy centres in Europe.   Fluka calculates the dose distribution for a patient treated at CNAO with proton beams. The colour-bar displays the normalized dose values. Fluka is a Monte Carlo code that very accurately simulates electromagnetic and nuclear interactions in matter. In the 1990s, in collaboration with NASA, the code was developed to predict potential radiation hazards received by space crews during possible future trips to Mars. Over the years, it has become the standard tool to investigate beam-machine interactions, radiation damage and radioprotection issues in the CERN accelerator com...

  3. Proton and heavy ion beam (charged particle therapy)

    International Nuclear Information System (INIS)

    Kanai, Tatsuaki

    2003-01-01

    There are distinguished therapeutic irradiation facilities of proton and heavy ion beam in Japan. The beam, due to its physical properties, is advantageous for focusing on the lesion in the body and for reducing the exposure dose to normal tissues, relative to X-ray. This makes it possible to irradiate the target lesion with the higher dose. The present review describes physical properties of the beam, equipments for the therapeutic irradiation, the respiratory-gated irradiation system, the layer-stacking irradiation system, therapy planning, and future prospect of the therapy. More than 1,400 patients have received the therapy in National Institute of Radiological Sciences (NIRS) and given a good clinical outcome. The targets are cancers of the head and neck, lung, liver, uterine and prostate, and osteosarcoma. The therapy of osteosarcoma is particularly important, which bringing about the high cure rate. Severe adverse effects are not seen with exception for the digestive tract ulcer. Many attempts like the respiratory-gated and layer-stacking systems and to shorten the therapy period to within 1 week are in progress. (N.I.)

  4. MIRKO - An interactive program for beam lines and synchrotrons

    International Nuclear Information System (INIS)

    Franczak, B.

    1984-01-01

    The ion-optical design of beam lines and synchrotrons is usually not done by a single run of one program. It takes many iterations of calculation, examination of results, and modification of input data. In most cases the first order design has to be followed by the investigation of higher order effects, i.e. chromatic and geometrical aberrations or resonance phenomena. The interactive computer program MIRKO is operated from a terminal and has a command structure, which enables the user to edit data, perform calculations, and to obtain alpha or graphics output on the terminal in any desired sequence. With graphics one can recognize the properties of an optical system much faster than with numbers only. Thus modifications of input data depending on the results of calculations can be made easily without stopping and restarting the program. Higher order effects can sometimes influence the first order design. Therefore, particle tracking capability was included in MIRKO as well as the calculation of stop band widths for synchrotrons. Consequently a large variety of phenomena can be studied with one program in one session based upon exactly the same data for the optical system and the possibility of fast switching between the different features

  5. High resolution line for secondary radioactive beams at the U400M cyclotron

    International Nuclear Information System (INIS)

    Rodin, A.M.; Sidorchuk, S.I.; Stepantsov, S.V.

    1996-01-01

    For implementation of an experimental program for studying nuclear reactions with radioactive ion beams in the energy domain of 20 through 80 MeV · A the high resolution beam line ACCULINNA was put into commissioning on a primary beam line of the JINR U-400M cyclotron. By means of nuclear fragmentation of the 14 N beam with the energy of 51 MeV · A on the 170 mg/cm 2 carbon target radioactive beams of 6 He, 8 He and 8 B were obtained. Possibilities of further development of the set-up are discussed. 6 refs., 7 figs., 2 tabs

  6. Beam transfer lines for the Tandem-superconducting cyclotron at Lab. Nazionale del Sud

    International Nuclear Information System (INIS)

    Calabretta, L.; Cuttone, G.; DiBernardo, P.; Giove, D.; Raia, G.; Yan, C.; Cao, L.; Liu, K.

    1988-01-01

    At the L.N.S. an MP-Tandem will be used as injector for the Superconducting Cyclotron. This paper describes the handling beam system for the Superconducting Cyclotron. All the lines are designed to be achromatic. Home made beam profile monitor is the main diagnostic device and its design and preliminary tests are presented. The distributed computer control for all the beam lines and bunching system is described too. The status of beam transfer line from tandem to S.C. and of bunching system is presented

  7. SLC beam line error analysis using a model-based expert system

    International Nuclear Information System (INIS)

    Lee, M.; Kleban, S.

    1988-02-01

    Commissioning particle beam line is usually a very time-consuming and labor-intensive task for accelerator physicists. To aid in commissioning, we developed a model-based expert system that identifies error-free regions, as well as localizing beam line errors. This paper will give examples of the use of our system for the SLC commissioning. 8 refs., 5 figs

  8. WE-A-207-02: Electron Beam Therapy - Current Status and Future Directions

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Q. [Duke University Medical Center (United States)

    2015-06-15

    In memory of the significant contribution of Dr. Jacques Ovadia to electron beam techniques, this session will review recent, advanced techniques which are reinvigorating the science of electron beam radiation therapy. Recent research efforts in improving both the applicability and quality of the electron beam therapy will be discussed, including modulated electron beam radiotherapy (MERT) and dynamic electron arc radiotherapy (DEAR). Learning Objectives: To learn about recent advances in electron beam therapy, including modulated electron beam therapy and dynamic electron arc therapy (DEAR). Put recent advances in the context of work that Dr. Ovadia pursued during his career in medical physics.

  9. WE-A-207-02: Electron Beam Therapy - Current Status and Future Directions

    International Nuclear Information System (INIS)

    Wu, Q.

    2015-01-01

    In memory of the significant contribution of Dr. Jacques Ovadia to electron beam techniques, this session will review recent, advanced techniques which are reinvigorating the science of electron beam radiation therapy. Recent research efforts in improving both the applicability and quality of the electron beam therapy will be discussed, including modulated electron beam radiotherapy (MERT) and dynamic electron arc radiotherapy (DEAR). Learning Objectives: To learn about recent advances in electron beam therapy, including modulated electron beam therapy and dynamic electron arc therapy (DEAR). Put recent advances in the context of work that Dr. Ovadia pursued during his career in medical physics

  10. Final design of the neutral beam lines for the Tokamak Fusion Test Reactor

    International Nuclear Information System (INIS)

    Pittenger, L.C.; Valby, L.E.; Stone, R.R.; Pedrotti, L.R.; Denhoy, B.; Yoard, R.

    1979-01-01

    Final design of the neutral beam lines for TFTR has been completed. A prototype has been assembled at Lawrence Berkeley Laboratory and is undergoing testing as part of the Neutral Beam System Test Facility (NBSTF). The final neutral beam line (NBL) configuration differs in several details from that previously reported upon; certain components have been added; and testing of the cryopump system has led to some design simplification. It is these developments which are reported herein

  11. SU-F-J-197: A Novel Intra-Beam Range Detection and Adaptation Strategy for Particle Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Chen, M; Jiang, S; Shao, Y; Lu, W [UT Southwestern Medical Center, Dallas, TX (United States)

    2016-06-15

    Purpose: In-vivo range detection/verification is crucial in particle therapy for effective and safe delivery. The state-of-art techniques are not sufficient for in-vivo on-line range verification due to conflicts among patient dose, signal statistics and imaging time. We propose a novel intra-beam range detection and adaptation strategy for particle therapy. Methods: This strategy uses the planned mid-range spots as probing beams without adding extra radiation to patients. Such choice of probing beams ensures the Bragg peaks to remain inside the tumor even with significant range variation from the plan. It offers sufficient signal statistics for in-beam positron emission tomography (PET) due to high positron activity of therapeutic dose. The probing beam signal can be acquired and reconstructed using in-beam PET that allows for delineation of the Bragg peaks and detection of range shift with ease of detection enabled by single-layered spots. If the detected range shift is within a pre-defined tolerance, the remaining spots will be delivered as the original plan. Otherwise, a fast re-optimization using range-shifted beamlets and accounting for the probing beam dose is applied to consider the tradeoffs posed by the online anatomy. Simulated planning and delivery studies were used to demonstrate the effectiveness of the proposed techniques. Results: Simulations with online range variations due to shifts of various foreign objects into the beam path showed successful delineation of the Bragg peaks as a result of delivering probing beams. Without on-line delivery adaptation, dose distribution was significantly distorted. In contrast, delivery adaptation incorporating detected range shift recovered well the planned dose. Conclusion: The proposed intra-beam range detection and adaptation utilizing the planned mid-range spots as probing beams, which illuminate the beam range with strong and accurate PET signals, is a safe, practical, yet effective approach to address range

  12. Reliability analysis of minimum energy on target for laser facilities with more beam lines

    International Nuclear Information System (INIS)

    Chen Guangyu

    2008-01-01

    Shot reliability performance measures of laser facilities with more beam lines pertain to three categories: minimum-energy-on-target, power balance, and shot diagnostics. Accounting for symmetry of NIF beam line design and similarity of subset reliability in a same partition, a fault tree of meeting minimum-energy-on-target for the large laser facility shot of type K and a simplified method are presented, which are used to analyze hypothetic reliability of partition subsets in order to get trends of influences increasing number of beam lines and diverse shot types of large laser facilities on their shot reliability. Finally, it finds that improving component reliability is more crucial for laser facilities with more beam lines in comparison with those with beam lines and functional diversity from design flexibility is greatly helpful for improving shot reliability. (authors)

  13. Proton beam therapy how protons are revolutionizing cancer treatment

    CERN Document Server

    Yajnik, Santosh

    2013-01-01

    Proton beam therapy is an emerging technology with promise of revolutionizing the treatment of cancer. While nearly half of all patients diagnosed with cancer in the US receive radiation therapy, the majority is delivered via electron accelerators, where photons are used to irradiate cancerous tissue. Because of the physical properties of photon beams, photons may deposit energy along their entire path length through the body. On the other hand, a proton beam directed at a tumor travels in a straight trajectory towards its target, gives off most of its energy at a defined depth called the Bragg peak, and then stops. While photons often deposit more energy within the healthy tissues of the body than within the cancer itself, protons can deposit most of their cancer-killing energy within the area of the tumor. As a result, in the properly selected patients, proton beam therapy has the ability to improve cure rates by increasing the dose delivered to the tumor and simultaneously reduce side-effects by decreasing...

  14. Clinical results of proton beam therapy for skull base chordoma

    International Nuclear Information System (INIS)

    Igaki, Hiroshi; Tokuuye, Koichi; Okumura, Toshiyuki; Sugahara, Shinji; Kagei, Kenji; Hata, Masaharu; Ohara, Kiyoshi; Hashimoto, Takayuki; Tsuboi, Koji; Takano, Shingo; Matsumura, Akira; Akine, Yasuyuki

    2004-01-01

    Purpose: To evaluate clinical results of proton beam therapy for patients with skull base chordoma. Methods and materials: Thirteen patients with skull base chordoma who were treated with proton beams with or without X-rays at the University of Tsukuba between 1989 and 2000 were retrospectively reviewed. A median total tumor dose of 72.0 Gy (range, 63.0-95.0 Gy) was delivered. The patients were followed for a median period of 69.3 months (range, 14.6-123.4 months). Results: The 5-year local control rate was 46.0%. Cause-specific, overall, and disease-free survival rates at 5 years were 72.2%, 66.7%, and 42.2%, respectively. The local control rate was higher, without statistical significance, for those with preoperative tumors <30 mL. Partial or subtotal tumor removal did not yield better local control rates than for patients who underwent biopsy only as the latest surgery. Conclusion: Proton beam therapy is effective for patients with skull base chordoma, especially for those with small tumors. For a patient with a tumor of <30 mL with no prior treatment, biopsy without tumor removal seems to be appropriate before proton beam therapy

  15. Differential acceleration in the final beam lines of a Heavy Ion Fusion driver

    Energy Technology Data Exchange (ETDEWEB)

    Friedman, Alex, E-mail: af@llnl.gov [Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States); The Virtual National Laboratory for Heavy Ion Fusion Science (United States)

    2014-01-01

    A long-standing challenge in the design of a Heavy Ion Fusion power plant is that the ion beams entering the target chamber, which number of order a hundred, all need to be routed from one or two multi-beam accelerators through a set of transport lines. The beams are divided into groups, each of which has a unique arrival time and may have a unique kinetic energy. It is also necessary to arrange for each beam to enter the target chamber from a prescribed location on the periphery of that chamber. Furthermore, it has generally been assumed that additional constraints must be obeyed: that the path lengths of the beams in a group must be equal, and that any delay of “main-pulse” beams relative to “foot-pulse” beams must be provided by the insertion of large delay-arcs in the main beam transport lines. Here we introduce the notion of applying “differential acceleration” to individual beams or sets of beams at strategic stages of the transport lines. That is, by accelerating some beams “sooner” and others “later,” it is possible to simplify the beam line configuration in a number of cases. For example, the time delay between the foot and main pulses can be generated without resorting to large arcs in the main-pulse beam lines. It is also possible to use differential acceleration to effect the simultaneous arrival on target of a set of beams (e.g., for the foot-pulse) without requiring that their path lengths be precisely equal. We illustrate the technique for two model configurations, one corresponding to a typical indirect-drive scenario requiring distinct foot and main energies, and the other to an ion-driven fast-ignition scenario wherein the foot and main beams share a common energy.

  16. Differential acceleration in the final beam lines of a Heavy Ion Fusion driver

    International Nuclear Information System (INIS)

    Friedman, Alex

    2014-01-01

    A long-standing challenge in the design of a Heavy Ion Fusion power plant is that the ion beams entering the target chamber, which number of order a hundred, all need to be routed from one or two multi-beam accelerators through a set of transport lines. The beams are divided into groups, each of which has a unique arrival time and may have a unique kinetic energy. It is also necessary to arrange for each beam to enter the target chamber from a prescribed location on the periphery of that chamber. Furthermore, it has generally been assumed that additional constraints must be obeyed: that the path lengths of the beams in a group must be equal, and that any delay of “main-pulse” beams relative to “foot-pulse” beams must be provided by the insertion of large delay-arcs in the main beam transport lines. Here we introduce the notion of applying “differential acceleration” to individual beams or sets of beams at strategic stages of the transport lines. That is, by accelerating some beams “sooner” and others “later,” it is possible to simplify the beam line configuration in a number of cases. For example, the time delay between the foot and main pulses can be generated without resorting to large arcs in the main-pulse beam lines. It is also possible to use differential acceleration to effect the simultaneous arrival on target of a set of beams (e.g., for the foot-pulse) without requiring that their path lengths be precisely equal. We illustrate the technique for two model configurations, one corresponding to a typical indirect-drive scenario requiring distinct foot and main energies, and the other to an ion-driven fast-ignition scenario wherein the foot and main beams share a common energy

  17. REQUIREMENTS AND GUIDELINES FOR NSLS EXPERIMENTAL BEAM LINE VACUUM SYSTEMS-REVISION B.

    Energy Technology Data Exchange (ETDEWEB)

    FOERSTER,C.

    1999-05-01

    Typical beam lines are comprised of an assembly of vacuum valves and shutters referred to as a ''front end'', optical elements to monochromatize, focus and split the photon beam, and an experimental area where a target sample is placed into the photon beam and data from the interaction is detected and recorded. Windows are used to separate sections of beam lines that are not compatible with storage ring ultra high vacuum. Some experimental beam lines share a common vacuum with storage rings. Sections of beam lines are only allowed to vent up to atmospheric pressure using pure nitrogen gas after a vacuum barrier is established to protect ring vacuum. The front end may only be bled up when there is no current in the machine. This is especially true on the VUV storage ring where for most experiments, windows are not used. For the shorter wavelength, more energetic photons of the x-ray ring, beryllium windows are used at various beam line locations so that the monochromator, mirror box or sample chamber may be used in a helium atmosphere or rough vacuum. The window separates ring vacuum from the environment of the downstream beam line components. The stored beam lifetime in the storage rings and the maintenance of desirable reflection properties of optical surfaces depend upon hydrocarbon-free, ultra-high vacuum systems. Storage ring vacuum systems will operate at pressures of {approximately} 1 x 10{sup {minus}10} Torr without beam and {approximately} 1 x 10{sup {minus}9} Torr with beam. Systems are free of hydrocarbons in the sense that no pumps, valves, etc. containing organics are used. Components are all-metal, chemically cleaned and bakeable. To the extent that beam lines share a common vacuum with the storage ring, the same criteria will hold for beam line components. The design philosophy for NSLS beam lines is to use all-metal, hydrocarbon-free front end components and recommend that experimenters use this approach for common vacuum hardware

  18. REQUIREMENTS AND GUIDELINES FOR NSLS EXPERIMENTAL BEAM LINE VACUUM SYSTEMS-REVISION B

    International Nuclear Information System (INIS)

    FOERSTER, C.

    1999-01-01

    Typical beam lines are comprised of an assembly of vacuum valves and shutters referred to as a ''front end'', optical elements to monochromatize, focus and split the photon beam, and an experimental area where a target sample is placed into the photon beam and data from the interaction is detected and recorded. Windows are used to separate sections of beam lines that are not compatible with storage ring ultra high vacuum. Some experimental beam lines share a common vacuum with storage rings. Sections of beam lines are only allowed to vent up to atmospheric pressure using pure nitrogen gas after a vacuum barrier is established to protect ring vacuum. The front end may only be bled up when there is no current in the machine. This is especially true on the VUV storage ring where for most experiments, windows are not used. For the shorter wavelength, more energetic photons of the x-ray ring, beryllium windows are used at various beam line locations so that the monochromator, mirror box or sample chamber may be used in a helium atmosphere or rough vacuum. The window separates ring vacuum from the environment of the downstream beam line components. The stored beam lifetime in the storage rings and the maintenance of desirable reflection properties of optical surfaces depend upon hydrocarbon-free, ultra-high vacuum systems. Storage ring vacuum systems will operate at pressures of ∼ 1 x 10 -10 Torr without beam and ∼ 1 x 10 -9 Torr with beam. Systems are free of hydrocarbons in the sense that no pumps, valves, etc. containing organics are used. Components are all-metal, chemically cleaned and bakeable. To the extent that beam lines share a common vacuum with the storage ring, the same criteria will hold for beam line components. The design philosophy for NSLS beam lines is to use all-metal, hydrocarbon-free front end components and recommend that experimenters use this approach for common vacuum hardware downstream of front ends. O-ring-sealed valves, if used, are not

  19. Computer system for the beam line data processing at JT-60 prototype neutral beam injector

    International Nuclear Information System (INIS)

    Horiike, Hiroshi; Kawai, Mikito; Ohara, Yoshihiro

    1987-08-01

    The present report describes the hard and soft wares of the data acquisition computer system for the prototype neutral injector unit for JT-60. In order to operate the unit, more than hundreds of signals of the beam line components have to be measured. These are mainly differential thermometers for the coolant waters and thermocouples for the beam dump components but not include those for the cryo system. Since the unit operates in a series of pulses, the measurement should be conducted very quickly in order to ensure the simultaneity of large number of the measured data. The present system actualize fast data acquisition using a small computer of 128 kB and measuring instruments connected through the bus. The system is connected to the JAERI computer center since the data capacity is fairly large to completely process them by the small computer. Therefore the measured data can be transferred to the computer center to calculate there, and the results can be received. After the system was completed the computer quickly print out the power flow data, which needed much work to calculate with hands. This system was very useful. It enhanced the experiments at the unit and reduced the labor. It enables us to early demonstrate the rated operation of the unit and to accurately estimate such operation data of the JT-60 NBI as the injection power. (author)

  20. The effects of magnetic fringe fields on beam dynamics in a beam transport line of a terahertz FEL source

    Energy Technology Data Exchange (ETDEWEB)

    Zeng, Han [State Key Laboratory of Advanced Electromagnetic Engineering and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei (China); Xiong, Yongqian, E-mail: yqxiong@mail.hust.edu.cn [State Key Laboratory of Advanced Electromagnetic Engineering and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei (China); Pei, Yuanji [National Synchrotron Radiation laboratory, University of Science and Technology of China, Hefei 230029, Anhui (China)

    2014-11-11

    The transport line used in a terahertz FEL device has to transport electron beam through the entire system efficiently and meet the requirements of the beam parameters at the undulator entrance. Due to space limitations, the size of the magnets (five quadrupoles and two bending magnets) employed in the transport line was limited, and some devices were densely packed. In this paper, analyses of the effect of fringe fields and magnetic interference of magnets are presented. 3D models of these magnets are built and their linear optical properties are compared with those obtained by hard edge models. The results indicated that the effects of these factors are significant and they would cause a mismatch of the beam at the exit of the transport line under the preliminary lattice design. To solve this problem, the beam was re-matched using the particle swarm optimization algorithm.

  1. The Experimental Verification of Gaussian Beam Coupling for ECH Transmission Line at 400 GHz

    Directory of Open Access Journals (Sweden)

    Choe Mun Seok

    2017-01-01

    Full Text Available We design a quasi-optical transmission line system for a 400 GHz gyrotron beam. The 400GHz Gaussian beam is injected to a corrugated waveguide bounced from a quasi-optical mirror. From detailed 2D field patterns of the output beam emitted from the corrugated waveguide, we analyze the mode contents and the source of non-ideal beam expansion

  2. An after-market, five-port vertical beam line extension for the PETtrace

    DEFF Research Database (Denmark)

    Barnhart, T. E.; Engle, J. W.; Severin, Gregory

    2012-01-01

    Most commercial cyclotrons intended for medical isotope production provide a limited number of beam ports crowded into a minimal vault space. Taking advantage of our new lab construction, we planned and installed a beam-line on port ♯2 of our GEMS PETtrace to bring beam to an additional 5 target...... positions. These are oriented in the vertical plane, with the downward directed beam well suited for molten target substrates. © 2012 American Institute of Physics...

  3. Monitoring beam position in the TRISTAN AR-to-MR transport lines

    International Nuclear Information System (INIS)

    Ieiri, Takao; Arinaga, Mitsuhiro

    1994-01-01

    A beam-position monitor (BPM) has been installed in the transport lines between the Accumulation Ring (AR) and the Main Ring (MR) of TRISTAN. This monitor can detect the beam position and its charge every passage of the beam. Variations of the beam position have been observed during the routine operation. An investigation into the AR extraction components has been carried out in order to clarify a source of the variations. (author)

  4. An after-market, five-port vertical beam line extension for the PETtrace

    Science.gov (United States)

    Barnhart, T. E.; Engle, J. W.; Severin, G. W.; Valdovinos, H. F.; Gagnon, K.; Nickles, R. J.

    2012-12-01

    Most commercial cyclotrons intended for medical isotope production provide a limited number of beam ports crowded into a minimal vault space. Taking advantage of our new lab construction, we planned and installed a beam-line on port ♯2 of our GEMS PETtrace to bring beam to an additional 5 target positions. These are oriented in the vertical plane, with the downward directed beam well suited for molten target substrates.

  5. An after-market, five-port vertical beam line extension for the PETtrace

    Energy Technology Data Exchange (ETDEWEB)

    Barnhart, T. E.; Engle, J. W.; Severin, G. W.; Valdovinos, H. F.; Gagnon, K.; Nickles, R. J. [Department of Medical Physics, University of Wisconsin, Madison, WI (United States); Los Alamos National Lab, Los Alamos, NM (United States); Hevesy Laboratory, Danish Technical University, Riso (Denmark); Department of Medical Physics, University of Wisconsin, Madison, WI (United States); Department of Radiology, University of Washington, Seattle, WA (United States); Department of Medical Physics, University of Wisconsin, Madison, WI (United States)

    2012-12-19

    Most commercial cyclotrons intended for medical isotope production provide a limited number of beam ports crowded into a minimal vault space. Taking advantage of our new lab construction, we planned and installed a beam-line on port Music-Sharp-Sign 2 of our GEMS PETtrace to bring beam to an additional 5 target positions. These are oriented in the vertical plane, with the downward directed beam well suited for molten target substrates.

  6. Nano-scale processes behind ion-beam cancer therapy

    Science.gov (United States)

    Surdutovich, Eugene; Garcia, Gustavo; Mason, Nigel; Solov'yov, Andrey V.

    2016-04-01

    This topical issue collates a series of papers based on new data reported at the third Nano-IBCT Conference of the COST Action MP1002: Nanoscale Insights into Ion Beam Cancer Therapy, held in Boppard, Germany, from October 27th to October 31st, 2014. The Nano-IBCT COST Action was launched in December 2010 and brought together more than 300 experts from different disciplines (physics, chemistry, biology) with specialists in radiation damage of biological matter from hadron-therapy centres, and medical institutions. This meeting followed the first and the second conferences of the Action held in October 2011 in Caen, France and in May 2013 in Sopot, Poland respectively. This conference series provided a focus for the European research community and has highlighted the pioneering research into the fundamental processes underpinning ion beam cancer therapy. Contribution to the Topical Issue "COST Action Nano-IBCT: Nano-scale Processes Behind Ion-Beam Cancer Therapy", edited by Andrey V. Solov'yov, Nigel Mason, Gustavo Garcia and Eugene Surdutovich.

  7. Third-line therapy for metastatic colorectal cancer

    DEFF Research Database (Denmark)

    Gundgaard, M.G.; Ehrnrooth, E.; Sørensen, Jens Benn

    2008-01-01

    BACKGROUND: The past years' therapy for colorectal cancer has evolved rapidly with the introduction of novel cytotoxic agents such as irinotecan, capecitabine and oxaliplatin. Further advances have been achieved with the integration of targeted agents such as bevacizumab, cetuximab and recently......, panitumumab. As a result, third-line treatment is now a necessary step in the optimal treatment of patients with metastatic colorectal cancer (MCRC). MATERIALS AND METHODS: We conducted a literature review of English language publications on third-line therapy for MCRC from January 2000 to April 2007. Data......OS of 16 months. With irinotecan and 5-FU, mOS around 8 months were reported and with cetuximab combined with irinotecan, the highest mOS was 9.8 months. CONCLUSION: Third-line therapy in advanced colorectal cancer may improve mOS for patients with MCRC. Therefore, randomized studies should be conducted...

  8. High intensity proton beam transportation through fringe field of 70 MeV compact cyclotron to beam line targets

    Science.gov (United States)

    Zhang, Xu; Li, Ming; Wei, Sumin; Xing, Jiansheng; Hu, Yueming; Johnson, Richard R.; Piazza, Leandro; Ryjkov, Vladimir

    2016-06-01

    From the stripping points, the high intensity proton beam of a compact cyclotron travels through the fringe field area of the machine to the combination magnet. Starting from there the beams with various energy is transferred to the switching magnet for distribution to the beam line targets. In the design of the extraction and transport system for the compact proton cyclotron facilities, such as the 70 MeV in France and the 100 MeV in China, the space charge effect as the beam crosses the fringe field has not been previously considered; neither has the impact on transverse beam envelope coupled from the longitudinal direction. Those have been concerned much more with the higher beam-power because of the beam loss problem. In this paper, based on the mapping data of 70 MeV cyclotron including the fringe field by BEST Cyclotron Inc (BEST) and combination magnet field by China Institute of Atomic Energy (CIAE), the beam extraction and transport are investigated for the 70 MeV cyclotron used on the SPES project at Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro (INFN-LNL). The study includes the space charge effect and longitudinal and transverse coupling mentioned above, as well as the matching of beam optics using the beam line for medical isotope production as an example. In addition, the designs of the ±45° switching magnets and the 60° bending magnet for the extracted beam with the energy from 35 MeV to 70 MeV have been made. Parts of the construction and field measurements of those magnets have been done as well. The current result shows that, the design considers the complexity of the compact cyclotron extraction area and fits the requirements of the extraction and transport for high intensity proton beam, especially at mA intensity levels.

  9. High intensity proton beam transportation through fringe field of 70 MeV compact cyclotron to beam line targets

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xu, E-mail: emmazhang103@gmail.com [China Institute of Atomic Energy (China); Li, Ming; Wei, Sumin; Xing, Jiansheng; Hu, Yueming [China Institute of Atomic Energy (China); Johnson, Richard R.; Piazza, Leandro; Ryjkov, Vladimir [BEST Cyclotron Inc (Canada)

    2016-06-01

    From the stripping points, the high intensity proton beam of a compact cyclotron travels through the fringe field area of the machine to the combination magnet. Starting from there the beams with various energy is transferred to the switching magnet for distribution to the beam line targets. In the design of the extraction and transport system for the compact proton cyclotron facilities, such as the 70 MeV in France and the 100 MeV in China, the space charge effect as the beam crosses the fringe field has not been previously considered; neither has the impact on transverse beam envelope coupled from the longitudinal direction. Those have been concerned much more with the higher beam-power because of the beam loss problem. In this paper, based on the mapping data of 70 MeV cyclotron including the fringe field by BEST Cyclotron Inc (BEST) and combination magnet field by China Institute of Atomic Energy (CIAE), the beam extraction and transport are investigated for the 70 MeV cyclotron used on the SPES project at Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro (INFN–LNL). The study includes the space charge effect and longitudinal and transverse coupling mentioned above, as well as the matching of beam optics using the beam line for medical isotope production as an example. In addition, the designs of the ±45° switching magnets and the 60° bending magnet for the extracted beam with the energy from 35 MeV to 70 MeV have been made. Parts of the construction and field measurements of those magnets have been done as well. The current result shows that, the design considers the complexity of the compact cyclotron extraction area and fits the requirements of the extraction and transport for high intensity proton beam, especially at mA intensity levels.

  10. Workshop on a project for a FZR-beam line at ESRF

    International Nuclear Information System (INIS)

    Matz, W.

    1993-10-01

    The Research Center Rossendorf (FZR) investigates the possibilities to install its own beam line as a Cooperate Research Group-project (CRG) at the European Synchrotron Radiation Facility (ESRF) in Grenoble. The main interests for the FZR to use high brillant synchrotron radiation are in the Institute of Radiochemistry and the Institute of Ion Beam Physics and Materials Research. This workshop was organized by these two institutes together with the FZR Study group Synchrotron. The purpose of the workshop was to achieve a better understanding for the technical needs of the projected beam line for the planned research projects. Experts with experience in beam line design met with the Rossendorf groups to discuss the best layout for such a beam line. The summary of this workshop and the copies of transparencies of the lectures that were given are published in this booklet. (orig.)

  11. Beam Transfer Line Design for a Plasma Wakefield Acceleration Experiment (AWAKE) at the CERN SPS

    CERN Document Server

    Bracco, C; Brethoux, D; Clerc, V; Goddard, B; Gschwendtner, E; Jensen, L K; Kosmicki, A; Le Godec, G; Meddahi, M; Muggli, P; Mutin, C; Osborne, O; Papastergiou, K; Pardons, A; Velotti, F M; Vincke, H

    2013-01-01

    The world’s first proton driven plasma wakefield acceleration experiment (AWAKE) is presently being studied at CERN. The experimentwill use a high energy proton beam extracted from the SPS as driver. Two possible locations for installing the AWAKE facility were considered: the West Area and the CNGS beam line. The previous transfer line from the SPS to the West Area was completely dismantled in 2005 and would need to be fully re-designed and re-built. For this option, geometric constraints for radiation protection reasons would limit the maximum proton beam energy to 300 GeV. The existing CNGS line could be used by applying only minor changes to the lattice for the final focusing and the interface between the proton beam and the laser, required for plasma ionisation and bunch-modulation seeding. The beam line design studies performed for the two options are presented.

  12. A beam position monitor for the diagnostic line in MEBT2 of J-PARC linac

    Science.gov (United States)

    Miura, A.; Tamura, J.; Kawane, Y.

    2017-07-01

    In the linac of the Japan Proton Accelerator Research Complex (J-PARC), the neutral hydrogen (H0) beam from the negative hydrogen ion (H-) beam is one of key issues in mitigating beam losses. To diagnose H0 particles, we installed a set of beam-bump magnets to generate a chicane orbit of the H- beam. The beam position monitors (BPMs) in the beam line are used for orbit correction to maintain the beam displacement within 2.0 mm from the duct center. To measure the beam displacement under different drive currents of the beam-bump magnets, a new wide-range BPM was designed and manufactured to evaluate the horizontal beam position by using a correction function to compensate for non-linearity. We also employed the beam profile monitor (WSM: wire scanner monitor) to measure the H- beam profile, which helped us to compare the beam position measurements. In this paper, the design and the performance of the wide-range BPM are described. In addition, we present a comparison of the beam position measured by the BPM and the WSM.

  13. A new concept for the control of a slow-extracted beam in a line with rotational optics, 2

    CERN Document Server

    Benedikt, Michael; Pullia, M

    1999-01-01

    For pt.I see ibid., vol.430, p.512-22, 1999. The current trend in hadron therapy is towards high-precision, conformal scanning of tumours with a `pencil' beam of light ions or protons, delivered by a synchrotron using slow extraction. The particular shape of the slow- extracted beam segment in phase space and the need to vary the beam size in a lattice with rotating optical elements create a special problem for the design of the extraction transfer line and gantry. The design concept presented in this report is based on telescope modules with integer- pi phase advances in both transverse planes. The beam size in the plane of the extraction is controlled by altering the phase advance and hence the rotation of the extracted beam segment in phase space. The vertical beam size is controlled by stepping the vertical betatron amplitude function over a range of values and passing the changed beam size from `hand-to-hand' through the telescope modules to the various treatment rooms. In the example given, a combined p...

  14. Skin protection by sucralfate cream during electron beam therapy

    International Nuclear Information System (INIS)

    Maiche, A.

    1994-01-01

    We performed a double-blind randomized study to compare the efficacy of sucralfate cream to a base cream in 50 breast cancer patients receiving postoperative electron beam therapy to their chest wall. The acute radiation reaction of the skin was statistically significantly prevented by the sucralfate cream. The recovery of the skin was also significantly faster in the sucralfate cream group. Side-effects due to the cream were rare. (orig./MG)

  15. Skin protection by sucralfate cream during electron beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Maiche, A. (Helsinki Univ. Central Hospital (Finland). Dept. of Radiotherapy and Oncology); Isokangas, O.P. (Helsinki Univ. Central Hospital (Finland). Dept. of Radiotherapy and Oncology); Groehn, P. (Deaconess Hospital, Helsinki (Finland))

    1994-01-01

    We performed a double-blind randomized study to compare the efficacy of sucralfate cream to a base cream in 50 breast cancer patients receiving postoperative electron beam therapy to their chest wall. The acute radiation reaction of the skin was statistically significantly prevented by the sucralfate cream. The recovery of the skin was also significantly faster in the sucralfate cream group. Side-effects due to the cream were rare. (orig./MG).

  16. Dosimetric properties of the fast neutron therapy beams at TAMVEC

    International Nuclear Information System (INIS)

    Almond, P.R.; Smith, A.R.; Smathers, J.R.; Otte, V.A.

    1975-01-01

    In October 1972, M.D. Anderson Hospital and Tumor Institute of the University of Texas System Cancer Center initiated a clinical trial of fast neutron radiotherapy using the cyclotron at Texas A and M University. Initially, the study used neutrons produced by bombarding beryllium with 16 MeV deuterons, but since March, 1973, neutrons from 50 MeV deuterons have been used. The dosimetric properties of the 30 MeV beams have also been measured for comparison with the neutron beams from D-T generators. The three beams are compared in terms of dose rate, skin sparing, depth dose and field flatness. Isodose curves for treatment planning were generated using the decrement line method and compared to curves measured by a computer controlled isodose plotter. This system was also used to measure the isodose curves for wedge fields. Dosimetry checks on various patients were made using silicon diodes as in vivo fast neutron dosimeters

  17. Controls and Beam Diagnostics for Therapy-Accelerators

    CERN Document Server

    Eickhoff, H

    2000-01-01

    During the last four years GSI has developed a new procedure for cancer treatment by means of the intensity controlled rasterscan-method. This method includes active variations of beam parameters during the treatment session and the integration of 'on-line' PET monitoring. Starting in 1997 several patients have been successfully treated within this GSI experimental cancer treatment program; within this program about 350 patients shall be treated in the next 5 years. The developments and experiences of this program accompanied by intensive discussions with the medical community led to a proposal for a hospital based light ion accelerator facility for the clinic in Heidelberg. An essential part for patients treatments is the measurement of the beam properties within acceptance and constancy tests and especially for the rasterscan method during the treatment sessions. The presented description of the accelerator controls and beam diagnostic devices mainly covers the requests for the active scanning method, which...

  18. Germ-line gene therapy and the medical imperative.

    Science.gov (United States)

    Munson, Ronald; Davis, Lawrence H

    1992-06-01

    Somatic cell gene therapy has yielded promising results. If germ cell gene therapy can be developed, the promise is even greater: hundreds of genetic diseases might be virtually eliminated. But some claim the procedure is morally unacceptable. We thoroughly and sympathetically examine several possible reasons for this claim but find them inadequate. There is no moral reason, then, not to develop and employ germ-line gene therapy. Taking the offensive, we argue next that medicine has a prima facie moral obligation to do so.

  19. Use of Third Line Antiretroviral Therapy in Latin America

    Science.gov (United States)

    Cesar, Carina; Shepherd, Bryan E.; Jenkins, Cathy A.; Ghidinelli, Massimo; Castro, Jose Luis; Veloso, Valdiléa Gonçalves; Cortes, Claudia P.; Padgett, Denis; Crabtree-Ramirez, Brenda; Gotuzzo, Eduardo; Fink, Valeria; Duran, Adriana; Sued, Omar; McGowan, Catherine C.; Cahn, Pedro

    2014-01-01

    Background Access to highly active antiretroviral therapy (HAART) is expanding in Latin America. Many patients require second and third line therapy due to toxicity, tolerability, failure, or a combination of factors. The need for third line HAART, essential for program planning, is not known. Methods Antiretroviral-naïve patients ≥18 years who started first HAART after January 1, 2000 in Caribbean, Central and South America Network (CCASAnet) sites in Argentina, Brazil, Honduras, Mexico, and Peru were included. Clinical trials participants were excluded. Third line HAART was defined as use of darunavir, tipranavir, etravirine, enfuvirtide, maraviroc or raltegravir. Need for third line HAART was defined as virologic failure while on second line HAART. Results Of 5853 HAART initiators followed for a median of 3.5 years, 310 (5.3%) failed a second line regimen and 44 (0.8%) received a third line regimen. Cumulative incidence of failing a 2nd or starting a 3rd line regimen was 2.7% and 6.0% three and five years after HAART initiation, respectively. Predictors at HAART initiation for failing a second or starting a third line included female sex (hazard ratio [HR] = 1.54, 95% confidence interval [CI] 1.18–2.00, p = 0.001), younger age (HR = 2.76 for 20 vs. 40 years, 95% CI 1.86–4.10, p<0.001), and prior AIDS (HR = 2.17, 95% CI 1.62–2.90, p<0.001). Conclusions Third line regimens may be needed for at least 6% of patients in Latin America within 5 years of starting HAART, a substantial proportion given the large numbers of patients on HAART in the region. Improved accessibility to third line regimens is warranted. PMID:25221931

  20. Use of third line antiretroviral therapy in Latin America.

    Directory of Open Access Journals (Sweden)

    Carina Cesar

    Full Text Available Access to highly active antiretroviral therapy (HAART is expanding in Latin America. Many patients require second and third line therapy due to toxicity, tolerability, failure, or a combination of factors. The need for third line HAART, essential for program planning, is not known.Antiretroviral-naïve patients ≥18 years who started first HAART after January 1, 2000 in Caribbean, Central and South America Network (CCASAnet sites in Argentina, Brazil, Honduras, Mexico, and Peru were included. Clinical trials participants were excluded. Third line HAART was defined as use of darunavir, tipranavir, etravirine, enfuvirtide, maraviroc or raltegravir. Need for third line HAART was defined as virologic failure while on second line HAART.Of 5853 HAART initiators followed for a median of 3.5 years, 310 (5.3% failed a second line regimen and 44 (0.8% received a third line regimen. Cumulative incidence of failing a 2nd or starting a 3rd line regimen was 2.7% and 6.0% three and five years after HAART initiation, respectively. Predictors at HAART initiation for failing a second or starting a third line included female sex (hazard ratio [HR] = 1.54, 95% confidence interval [CI] 1.18-2.00, p = 0.001, younger age (HR = 2.76 for 20 vs. 40 years, 95% CI 1.86-4.10, p<0.001, and prior AIDS (HR = 2.17, 95% CI 1.62-2.90, p<0.001.Third line regimens may be needed for at least 6% of patients in Latin America within 5 years of starting HAART, a substantial proportion given the large numbers of patients on HAART in the region. Improved accessibility to third line regimens is warranted.

  1. The on-line beam control and diagnosis system of TARN

    International Nuclear Information System (INIS)

    Takanaka, M.; Watanabe, S.; Chiba, K.; Katayama, T.; Noda, A.

    1982-04-01

    The computer network in TARN is composed of a central main frame computer, two different minicomputers and several microprocessors. It has been used for the beam control and the beam diagnosis; support for adjustment of elements of the transport line and the ring, generation of RF voltage function, measurement of beam profile at RF stacking, on-line measurement of ν:value, and observation of Schottky signal. By the use of this computer system, the operation of TARN has been effectively and steadily performed, and additionally it has contributed to measuring the beam characteristics precisely in the ring. (author)

  2. The Brookhaven ATF low-emittance beam line

    International Nuclear Information System (INIS)

    Wang, X.J.; Kirk, H.G.

    1991-01-01

    One component of the experimental program at the Brookhaven Accelerator Test Facility (ATF) consists of a class of experiments which will study the acceleration of electrons through micron-size structures which are exposed in coincidence to a 100 GW CO 2 laser beam. These experiments require the development and control of an electron beam with geometric emittances on the order of 10 -10 m-rad and intensities on the order of 10 6 electrons. In this paper, the authors describe the strategies for producing such beams and the effects of higher-order aberrations. Particle tracking results are presented for the final-focus system

  3. The Brookhaven ATF low-emittance beam line

    International Nuclear Information System (INIS)

    Wang, X.J.

    1991-01-01

    One component of the experimental program at the Brookhaven Accelerator Test Facility (ATF) consists of a class of experiments which will study the acceleration of electrons through micron-size structures which are exposed in coincidence to a 100 GW CO 2 laser beam. These experiments require the development and control of an electron beam with geometric emittances on the order of 10 -10 m-rad and intensities on the order of 10 6 electrons. In this paper, we describe the strategies for producing such beams and the effects of high-order aberrations. Particle tracking results are presented for the final-focus system. 9 refs., 6 figs., 2 tabs

  4. NSLS infra-red beam line (U3) conceptual design report

    Energy Technology Data Exchange (ETDEWEB)

    Williams, G.P.

    1984-02-09

    We describe the conceptual design of an infrared (I-R) beam line on the vacuum-ultra-violet storage ring of the National Synchrotron Light Source. The beam line forms part of the Phase II expansion of the NSLS. Consistent with the implementation of the current design is the extraction of hitherto wasted radiation and the establishment of a mezzanine floor or platform to make full use of the available headroom. This means that the I-R beam line, once established, does not interfere with any existing operations on the VUV floor.

  5. Developing an expert system to control a beam line at the Los Alamos Meson Physics Facility

    International Nuclear Information System (INIS)

    Clearwater, S.H.; Papcun, G.; Clark, D.A.

    1985-01-01

    High energy particle experiments require an accelerator as a source of high energy particles. To increase the productivity of an accelerator facility, we wish to develop an expert system to control beam lines. Expert Systems are a branch of Artificial Intelligence where a computer program performs tasks requiring human expertise. Unlike most expert systems we have a physical model underlying our beam line and this model can be used with the expert system to improve performance. The development of the expert system will lead to an increased understanding of the beam line as well as the possibility of state-of-the-art expert system building

  6. A standardized method for beam design in neutron capture therapy

    International Nuclear Information System (INIS)

    Storr, G.J.: Harrington, B.V.

    1993-01-01

    A desirable end point for a given beam design for Neutron Capture Therapy (NCT) should be quantitative description of tumour control probability and normal tissue damage. Achieving this goal will ultimately rely on data from NCT human clinical trials. Traditional descriptions of beam designs have used a variety of assessment methods to quantify proposed or installed beam designs. These methods include measurement and calculation of open-quotes free fieldclose quotes parameters, such as neutron and gamma flux intensities and energy spectra, and figures-of-merit in tissue equivalent phantoms. The authors propose here a standardized method for beam design in NCT. This method would allow all proposed and existing NCT beam facilities to be compared equally. The traditional approach to determining a quantitative description of tumour control probability and normal tissue damage in NCT research may be described by the following path: Beam design → dosimetry → macroscopic effects → microscopic effects. Methods exist that allow neutron and gamma fluxes and energy dependence to be calculated and measured to good accuracy. By using this information and intermediate dosimetric quantities such as kerma factors for neutrons and gammas, macroscopic effect (absorbed dose) in geometries of tissue or tissue-equivalent materials can be calculated. After this stage, for NCT the data begins to become more sparse and in some areas ambiguous. Uncertainties in the Relative Biological Effectiveness (RBE) of some NCT dose components means that beam designs based on assumptions considered valid a few years ago may have to be reassessed. A standard method is therefore useful for comparing different NCT facilities

  7. Engineering Design of Electrostatic Quadrupole for ISOL Beam Lines

    International Nuclear Information System (INIS)

    Kim, H. S.; Kwon, H. J.; Cho, Y. S.

    2014-01-01

    In the ISOL system, the RI beam should be transported from the target ion source to post accelerator through various analyzing and charge-breeding systems such as PS (pre-seperator), HRMS (High Resolution Mass Seperator), RF cooler and A/q separator. A reference particle for the beam dynamics calculation is 132 Sn 1+ . After charge breeder system, the charge state is boosted from +1 to +19 with ECR charge breeder and to +33 with EBIS charge breeder. Because the beam energy is as low as 50 keV, the electrostatic optics was adopted rather than the magnetic optics. The electrostatic quadrupole triplets were used for the beam focusing and the electrostatic bender is used for 90-degree bending. In this paper, the design procedure and engineering design of the electrostatic quadrupole are presented

  8. Optics calculations and beam line design for the JANNuS facility in Orsay

    International Nuclear Information System (INIS)

    Chauvin, N.; Henry, S.; Flocard, H.; Fortuna, F.; Kaitasov, O.; Pariset, P.; Pellegrino, S.; Ruault, M.O.; Serruys, Y.; Trocelier, P.

    2007-01-01

    JANNuS (Joint Accelerators for Nano-Science and Nuclear Simulation) will be a unique user facility in Europe dedicated to material modification by ion beam implantation and irradiation. The main originality of the project is that it will be possible to perform implantation and irradiation with simultaneous multiple ions beams and in situ characterization by transmission electron microscopy (TEM) observation or ion beam analysis. This facility will be composed of two experimental platforms located in two sites: the CEA-SRMP in Saclay and the CNRS-CSNSM in Orsay. This paper will focus on the design of two new transport beam lines for the Orsay site. One of the most challenging parts of the JANNuS project (Orsay site) is to design two new beam lines in order to inject, into a 200 kV TEM, two different ion beams (low and medium energy) coming from two existing pieces of equipment: a 2 MV Tandem accelerator and a 190 kV ion implanter. For these new beam lines, first order beam calculations have been done using transfer matrix formalism. A genetic algorithm has been written and adapted to perform the optimization of the beam line parameters. Then, using the SIMION code, field maps of the electrostatic elements (quadrupoles, spherical sectors) have been calculated and ion trajectories have been simulated. We studied specifically the optical aberrations induced by the electrostatic spherical deflectors. Finally, the results of the first order calculations and the field map simulations show a good agreement

  9. Design and initial tests of beam current monitoring systems for the APS transport lines

    International Nuclear Information System (INIS)

    Wang, Xucheng.

    1992-01-01

    The non-intercepting beam current monitoring systems suitable for a wide, range of beam parameters have been developed for the Advanced Photon Source (APS) low energy transport lines and high energy transport line. The positron or electron beam pulse in the transport lines wig have peak beam currents ranging from 8 mA to 29 A with pulse widths varying from 120 ps to 30 ns and pulse repetition rates from 2 Hz to 60 Hz. The peak beam current or total beam charge is measured with the fast or integrating current transformer, respectively, manufactured by Bergoz. In-house high speed beam signal processing electronics provide a DC level output proportional to the peak current or total charge for the digitizer input. The prototype systems were tested on the linacs which have beam pulse structures similar to that of the APS transport lines. This paper describes the design of beam signal processing electronics and grounding and shielding methods for current transformers. The results of the initial operations are presented. A short introduction on the preliminary design of current monitoring systems for the APS rings is also included

  10. Commissioning status of the decelerator test beam line in CTF3

    CERN Document Server

    Adli, E; Lillestol, R; Olvegaard, M; Syratchev, I; Carrillo, D; Toral, F; Faus-Golfe, A; Garcia-Garrigos, J J; Kubyshin, Y; Montoro, G

    2010-01-01

    The CLIC Test Facility (CTF3) at CERN was constructed by the CTF3 collaboration to study the feasibility of the concepts for a compact linear collider. The test beam line (TBL) recently added to the CTF3 machine was designed to study the CLIC decelerator beam dynamics and 12 GHz power production. The beam line consists of a FODO lattice with high precision BPM’s and quadrupoles on movers for precise beam alignment. A total of 16 Power Extraction and Transfer Structures (PETS) will be installed in between the quadrupoles to extract 12 GHz power from the drive beam provided by the CTF3 machine. The CTF3 drive beam with a bunch-train length of 140 ns, 12 GHz bunch repetition frequency and an average current over the train of up to 28 A will be injected into the test beam line. Each PETS structure will produce 135 MW of 12 GHz power at nominal current. The beam will have lost more than 50 % of its initial energy of 150 MeV at the end of the beam line and will contain particles with energies between 65 MeV and 1...

  11. The MICE Muon Beam on ISIS and the beam-line instrumentation of the Muon Ionization Cooling Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Bogomilov, M. [University of Sofia (Bulgaria); et al.

    2012-05-01

    The international Muon Ionization Cooling Experiment (MICE), which is under construction at the Rutherford Appleton Laboratory (RAL), will demonstrate the principle of ionization cooling as a technique for the reduction of the phase-space volume occupied by a muon beam. Ionization cooling channels are required for the Neutrino Factory and the Muon Collider. MICE will evaluate in detail the performance of a single lattice cell of the Feasibility Study 2 cooling channel. The MICE Muon Beam has been constructed at the ISIS synchrotron at RAL, and in MICE Step I, it has been characterized using the MICE beam-instrumentation system. In this paper, the MICE Muon Beam and beam-line instrumentation are described. The muon rate is presented as a function of the beam loss generated by the MICE target dipping into the ISIS proton beam. For a 1 V signal from the ISIS beam-loss monitors downstream of our target we obtain a 30 KHz instantaneous muon rate, with a neglible pion contamination in the beam.

  12. The MICE Muon Beam on ISIS and the beam-line instrumentation of the Muon Ionization Cooling Experiment

    CERN Document Server

    Bogomilov, M.; Kolev, D.; Russinov, I.; Tsenov, R.; Vankova-Kirilova, G.; Wang, L.; Xu, F.Y.; Zheng, S.X.; Bertoni, R.; Bonesini, M.; Ferri, F.; Lucchini, G.; Mazza, R.; Paleari, F.; Strati, F.; Palladino, V.; Cecchet, G.; de Bari, A.; Capponi, M.; Cirillo, A.; Iaciofano, A.; Manfredini, A.; Parisi, M.; Orestano, D.; Pastore, F.; Tonazzo, A.; Tortora, L.; Mori, Y.; Kuno, Y.; Sakamoto, H.; Sato, A.; Yano, T.; Yoshida, M.; Ishimoto, S.; Suzuki, S.; Yoshimura, K.; Filthaut, F.; Garoby, R.; Gilardoni, S.; Gruber, P.; Hanke, K.; Haseroth, H.; Janot, P.; Lombardi, A.; Ramberger, S.; Vretenar, M.; Bene, P.; Blondel, A.; Cadoux, F.; Graulich, J.S.; Grichine, V.; Gschwendtner, E.; Masciocchi, F.; Sandstrom, R.; Verguilov, V.; Wisting, H.; Petitjean, C.; Seviour, R.; Alexander, J.; Charnley, G.; Collomb, N.; Griffiths, S.; Martlew, B.; Moss, A.; Mullacrane, I.; Oates, A.; Owens, P.; White, C.; York, S.; Adams, D.; Apsimon, R.; Barclay, P.; Baynham, D.E.; Bradshaw, T.W.; Courthold, M.; Drumm, P.; Edgecock, R.; Hayler, T.; Hills, M.; Ivaniouchenkov, Y.; Jones, A.; Lintern, A.; MacWaters, C.; Nelson, C.; Nichols, A.; Preece, R.; Ricciardi, S.; Rochford, J.H.; Rogers, C.; Spensley, W.; Tarrant, J.; Tilley, K.; Watson, S.; Wilson, A.; Forrest, D.; Soler, F.J.P.; Walaron, K.; Cooke, P.; Gamet, R.; Alekou, A.; Apollonio, M.; Barber, G.; Clark, D.; Clark, I.; Dobbs, A.; Dornan, P.; Fish, A.; Hare, R.; Greenwood, S.; Jamdagni, A.; Kasey, V.; Khaleeq, M.; Leaver, J.; Long, K.; McKigney, E.; Matsushita, T.; Pasternak, J.; Sashalmi, T.; Savidge, T.; Takahashi, M.; Blackmore, V.; Carlisle, T.; Cobb, J.H.; Lau, W.; Rayner, M.; Tunnell, C.D.; Witte, H.; Yang, S.; Booth, C.N.; Hodgson, P.; Howlett, L.; Nicholson, R.; Overton, E.; Robinson, M.; Smith, P.; Adey, D.; Back, J.; Boyd, S.; Harrison, P.; Ellis, M.; Kyberd, P.; Littlefield, M.; Nebrensky, J.J.; Bross, A.D.; Geer, S.; Neuffer, D.; Moretti, A.; Popovic, M.; Cummings, M.A.C.; Roberts, T.J.; DeMello, A.; Green, M.A.; Li, D.; Virostek, S.; Zisman, M.S.; Freemire, B.; Hanlet, P.; Huang, D.; Kafka, G.; Kaplan, D.M.; Snopok, P.; Torun, Y.; Blot, S.; Kim, Y.K.; Bravar, U.; Onel, Y.; Cline, D.; Fukui, Y.; Lee, K.; Yang, X.; Rimmer, R.A.; Cremaldi, L.M.; Gregoire, G.; Hart, T.L.; Sanders, D.A.; Summers, D.J.; Coney, L.; Fletcher, R.; Hanson, G.G.; Heidt, C.; Gallardo, J.; Kahn, S.; Kirk, H.; Palmer, R.B.

    2012-01-01

    The international Muon Ionization Cooling Experiment (MICE), which is under construction at the Rutherford Appleton Laboratory (RAL), will demonstrate the principle of ionization cooling as a technique for the reduction of the phase-space volume occupied by a muon beam. Ionization cooling channels are required for the Neutrino Factory and the Muon Collider. MICE will evaluate in detail the performance of a single lattice cell of the Feasibility Study 2 cooling channel. The MICE Muon Beam has been constructed at the ISIS synchrotron at RAL, and in MICE Step I, it has been characterized using the MICE beam-instrumentation system. In this paper, the MICE Muon Beam and beam-line instrumentation are described. The muon rate is presented as a function of the beam loss generated by the MICE target dipping into the ISIS proton beam. For a 1 V signal from the ISIS beam-loss monitors downstream of our target we obtain a 30 KHz muon rate, with a neglible pion contamination in the beam.

  13. A line scanned light-sheet microscope with phase shaped self-reconstructing beams.

    Science.gov (United States)

    Fahrbach, Florian O; Rohrbach, Alexander

    2010-11-08

    We recently demonstrated that Microscopy with Self-Reconstructing Beams (MISERB) increases both image quality and penetration depth of illumination beams in strongly scattering media. Based on the concept of line scanned light-sheet microscopy, we present an add-on module to a standard inverted microscope using a scanned beam that is shaped in phase and amplitude by a spatial light modulator. We explain technical details of the setup as well as of the holograms for the creation, positioning and scaling of static light-sheets, Gaussian beams and Bessel beams. The comparison of images from identical sample areas illuminated by different beams allows a precise assessment of the interconnection between beam shape and image quality. The superior propagation ability of Bessel beams through inhomogeneous media is demonstrated by measurements on various scattering media.

  14. High intensity beam profile monitors for the LAMPF primary beam lines

    International Nuclear Information System (INIS)

    Hoffman, E.W.; Macek, R.J.; van Dyck, O.; Lee, D.; Harvey, A.; Bridge, J.; Cainet, J.

    1979-01-01

    Two types of beam profile monitors are in use at LAMPF to measure the properties of the 800 MeV, 500 μA proton beam external to the linac. Both types use secondary electron emission from a wire to produce a current signal proportional to the amount of proton beam that intercepts the wire. The wire scanner system uses a pair of orthogonal wires which are passed through the beam and the harp system uses two fixed planes of parallel wires. Most of the harps are not retractable and are exposed continuously to the primary beam. The high beam intensities available lead to a number of technical problems for instruments that intercept the beam or are close to primary beam targets. The thermal, electrical, radiation-damage, and material selection problems encountered, and some solutions which have been implemented are discussed

  15. Design of the prototype of a beam transport line for handling and selection of low energy laser-driven beams

    Energy Technology Data Exchange (ETDEWEB)

    Schillaci, F., E-mail: francesco.schillaci@eli-beams.eu [INFN-LNS, Catania (Italy); Maggiore, M. [INFN-LNL, Legnaro (Italy); Cirrone, G.A.P.; Cuttone, G.; Pisciotta, P.; Costa, M.; Rifuggiato, D.; Romano, F. [INFN-LNS, Catania (Italy); Scuderi, V. [INFN-LNS, Catania (Italy); Institute of Physics of the ASCR, ELI-Beamlines Project, Prague (Czech Republic)

    2016-11-21

    A first prototype of transport beam-line for laser-driven ion beams to be used for the handling of particles accelerated by high-power laser interacting with solid targets has been realized at INFN. The goal is the production of a controlled and stable beam in terms of energy and angular spread. The beam-line consists of two elements: an Energy Selection System (ESS), already realized and characterized with both conventional and laser-accelerated beams, and a Permanent Magnet Quadrupole system (PMQ) designed, in collaboration with SIGMAPHI (Fr), to improve the ESS performances. In this work a description of the ESS system and some results of its characterization with conventional beams are reported, in order to provide a complete explanation of the acceptance calculation. Then, the matching with the PMQ system is presented and, finally, the results of preliminary simulations with a realistic laser-driven energy spectrum are discussed demonstrating the possibility to provide a good quality beam downstream the systems.

  16. Time Resolved Spectrometry on the Test Beam Line at CTF3

    CERN Document Server

    Olvegård, M; Lefèvre, T; Döbert, S; Adli, E

    2009-01-01

    The CTF3 provides a high current (28 A) high frequency (12 GHz) electron beam, which is used to generate high power radiofrequency pulses at 12 GHz by decelerating the electrons in resonant structures. A Test Beam Line (TBL) is currently being built in order to prove the efficiency and the reliability of the RF power production with the lowest level of particle losses. As the beam propagates along the line, its energy spread grows up to 60%. For instrumentation, this unusual characteristic implies the development of new and innovative techniques. One of the most important tasks is to measure the beam energy spread with a fast time resolution. The detector must be able to detect the energy transient due to beam loading in the decelerating structures (nanosecond) but should also be capable to measure bunch-to-bunch fluctuations (12 GHz). This paper presents the design of the spectrometer line detectors.

  17. Transport and dosimetric solutions for the ELIMED laser-driven beam line

    Energy Technology Data Exchange (ETDEWEB)

    Cirrone, G.A.P. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Romano, F. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Medical Physics School, University of Catania, Via S. Sofia 64 - 95125 Catania (Italy); Scuderi, V. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Institute of Physics ASCR, v.v.i. (FZU), ELI-Beamlines Project, Na Slovance 2, 182 21 Prague (Czech Republic); Amato, A. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Candiano, G. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Medical Physics School, University of Catania, Via S. Sofia 64 - 95125 Catania (Italy); Cuttone, G. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Giove, D. [INFN Sezione di Milano, Via Celoria 16, Milano (Italy); Korn, G.; Krasa, J. [Institute of Physics ASCR, v.v.i. (FZU), ELI-Beamlines Project, Na Slovance 2, 182 21 Prague (Czech Republic); Leanza, R. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Universitá degli Studi di Catania, Dipartimento di Fisica e Astronomia, Via S. Sofia 64, Catania (Italy); Manna, R. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Maggiore, M. [INFN-LNL, Viale dell' Universitá 2 - 35020 Legnaro (PD) (Italy); Marchese, V. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Margarone, D. [Institute of Physics ASCR, v.v.i. (FZU), ELI-Beamlines Project, Na Slovance 2, 182 21 Prague (Czech Republic); Milluzzo, G. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Universitá degli Studi di Catania, Dipartimento di Fisica e Astronomia, Via S. Sofia 64, Catania (Italy); Petringa, G. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Sabini, M.G. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Azienda Ospedaliera Cannizzaro, Via Messina 829 - 95100 Catania (Italy); Schillaci, F. [INFN-LNS, Via S. Sofia 62 - 95125 Catania (Italy); Medical Physics School, University of Catania, Via S. Sofia 64 - 95125 Catania (Italy); and others

    2015-10-01

    Within 2017, the ELIMED (ELI-Beamlines MEDical applications) transport beam-line and dosimetric systems for laser-generated beams will be installed at the ELI-Beamlines facility in Prague (CZ), inside the ELIMAIA (ELI Multidisciplinary Applications of laser–Ion Acceleration) interaction room. The beam-line will be composed of two sections: one in vacuum, devoted to the collecting, focusing and energy selection of the primary beam and the second in air, where the ELIMED beam-line dosimetric devices will be located. This paper briefly describes the transport solutions that will be adopted together with the main dosimetric approaches. In particular, the description of an innovative Faraday Cup detector with its preliminary experimental tests will be reported.

  18. Beam Line Design and Beam Physics Study of Energy Recovery Linac Free Electron Laser at Peking University

    International Nuclear Information System (INIS)

    Wang, Guimei

    2011-01-01

    Energy recovering linac (ERL) offers an attractive alternative for generating intense beams of charged particles by approaching the operational efficiency of a storage ring while maintaining the superior beam quality typical of a linear accelerator. In ERLs, the decelerated beam cancels the beam loading effects of the accelerated beam with high repetition rate. Therefore, ERLs can, in principle, accelerate very high average currents with only modest amounts of RF power. So the efficiency of RF power to beam is much higher. Furthermore, the energy of beam to dump is lower, so it will reduce dump radiation. With the successful experiments in large maximum-to-injection energy ratio up to 51:1 and high power FEL up to 14kW, the use of ERL, especially combining with superconducting RF technology, provides a potentially powerful new paradigm for generation of the charged particle beams used in MW FEL, synchrotron radiation sources, high-energy electron cooling devices and so on. The 3+1/2 DC-SC photo injector and two 9cell TESLA superconducting cavity for IR SASE FEL in PKU provides a good platform to achieve high average FEL with Energy Recovery. The work of this thesis is on Beam line design and Beam dynamics study of Energy Recovery Linac Free Electron Laser for Peking University. It is the upgrade of PKU facility, which is under construction. With ERL, this facility can work in CW mode, so it can operate high average beam current without RF power constraint in main linac and generate high average FEL power. Moreover, it provides a test facility to study the key technology in ERL. System parameters are optimized for PKU ERL-FEL. The oscillation FEL output power is studied with different bunch charge, transverse emittance, bunch length and energy spread. The theory of optimal RF power and Q ext with ERL and without ERL is analyzed and applied to PKU injector and linac including microphonic effect. pace charge effect in the injector and merger is studied for beam energy

  19. Beam Line Design and Beam Physics Study of Energy Recovery Linac Free Electron Laser at Peking University

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Guimei [Peking Univ., Beijing (China)

    2011-12-31

    Energy recovering linac (ERL) offers an attractive alternative for generating intense beams of charged particles by approaching the operational efficiency of a storage ring while maintaining the superior beam quality typical of a linear accelerator. In ERLs, the decelerated beam cancels the beam loading effects of the accelerated beam with high repetition rate. Therefore, ERLs can, in principle, accelerate very high average currents with only modest amounts of RF power. So the efficiency of RF power to beam is much higher. Furthermore, the energy of beam to dump is lower, so it will reduce dump radiation. With the successful experiments in large maximum-to-injection energy ratio up to 51:1 and high power FEL up to 14kW, the use of ERL, especially combining with superconducting RF technology, provides a potentially powerful new paradigm for generation of the charged particle beams used in MW FEL, synchrotron radiation sources, high-energy electron cooling devices and so on. The 3+1/2 DC-SC photo injector and two 9cell TESLA superconducting cavity for IR SASE FEL in PKU provides a good platform to achieve high average FEL with Energy Recovery. The work of this thesis is on Beam line design and Beam dynamics study of Energy Recovery Linac Free Electron Laser for Peking University. It is the upgrade of PKU facility, which is under construction. With ERL, this facility can work in CW mode, so it can operate high average beam current without RF power constraint in main linac and generate high average FEL power. Moreover, it provides a test facility to study the key technology in ERL. System parameters are optimized for PKU ERL-FEL. The oscillation FEL output power is studied with different bunch charge, transverse emittance, bunch length and energy spread. The theory of optimal RF power and Q{sub ext} with ERL and without ERL is analyzed and applied to PKU injector and linac including microphonic effect. pace charge effect in the injector and merger is studied for beam

  20. Operational experience with synchrotron light interferometers for CEBAF experimental beam lines

    Energy Technology Data Exchange (ETDEWEB)

    Pavel Chevtsov

    2006-10-24

    Beam size and energy spread monitoring systems based on Synchrotron Light Interferometers (SLI) have been in operations at Jefferson Lab for several years. A non-invasive nature and a very high (a few mm) resolution of SLI make these instruments valuable beam diagnostic tools for the CEBAF accelerator. This presentation describes the evolution of the Synchrotron Light Interferometer at Jefferson Lab and highlights our extensive experience in the installation and operation of the SLI for CEBAF experimental beam lines.

  1. Pitfalls of tungsten multileaf collimator in proton beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Moskvin, Vadim; Cheng, Chee-Wai; Das, Indra J. [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202 (United States) and Indiana University Health Proton Therapy Center (Formerly Midwest Proton Radiotherapy Institute), Bloomington, Indiana 47408 (United States)

    2011-12-15

    Purpose: Particle beam therapy is associated with significant startup and operational cost. Multileaf collimator (MLC) provides an attractive option to improve the efficiency and reduce the treatment cost. A direct transfer of the MLC technology from external beam radiation therapy is intuitively straightforward to proton therapy. However, activation, neutron production, and the associated secondary cancer risk in proton beam should be an important consideration which is evaluated. Methods: Monte Carlo simulation with FLUKA particle transport code was applied in this study for a number of treatment models. The authors have performed a detailed study of the neutron generation, ambient dose equivalent [H*(10)], and activation of a typical tungsten MLC and compared with those obtained from a brass aperture used in a typical proton therapy system. Brass aperture and tungsten MLC were modeled by absorber blocks in this study, representing worst-case scenario of a fully closed collimator. Results: With a tungsten MLC, the secondary neutron dose to the patient is at least 1.5 times higher than that from a brass aperture. The H*(10) from a tungsten MLC at 10 cm downstream is about 22.3 mSv/Gy delivered to water phantom by noncollimated 200 MeV beam of 20 cm diameter compared to 14 mSv/Gy for the brass aperture. For a 30-fraction treatment course, the activity per unit volume in brass aperture reaches 5.3 x 10{sup 4} Bq cm{sup -3} at the end of the last treatment. The activity in brass decreases by a factor of 380 after 24 h, additional 6.2 times after 40 days of cooling, and is reduced to background level after 1 yr. Initial activity in tungsten after 30 days of treating 30 patients per day is about 3.4 times higher than in brass that decreases only by a factor of 2 after 40 days and accumulates to 1.2 x 10{sup 6} Bq cm{sup -3} after a full year of operation. The daily utilization of the MLC leads to buildup of activity with time. The overall activity continues to increase

  2. A GIF++ Gamma Irradiation Facility at the SPS H4 Beam Line

    CERN Document Server

    Capéans-Garrido, M; Linssen, L; Moll, M; Rembser, C

    2009-01-01

    The current document describes a proposal to implement a new gamma irradiation facility, combined with a high-energy particle beam in the SPS H4 beam line in hall EHN1. This new GIF++ facility is motivated by strong needs from the LHC and sLHC detector and accelerator communities for the tests of LHC components and systems.

  3. Faraday cup: absolute dosimetry for ELIMED beam line

    International Nuclear Information System (INIS)

    Leanza, R.; Romano, F.; Scuderi, V.; Amico, A.G.; Cuttone, G.; Larosa, G.; Milluzzo, G.; Petringa, G.; Pipek, J.; Cirrone, G.A.P.; Margarone, D.; Schillaci, F.

    2017-01-01

    The scientific community has shown a growing interest towards multidisciplinary applications of laser-driven beams. In this framework, the ELIMED (ELI-Beamlines MEDical and multidisciplinary applications) beamline will be the first transport beamline dedicated to the medical and multidisciplinary studies with laser-accelerated ion beams. Detectors for dosimetry represent one of key-element of the ELIMED beamline, allowing a dose delivering with good result as required in the clinical applications. In this contribution, a Faraday Cup for absolute dosimetry, designed and realized at INFN-LNS, is described.

  4. An interactive beam line simulator module for RHIC

    International Nuclear Information System (INIS)

    MacKay, W.W.

    1997-01-01

    This paper describes the interactive simulation engine, bl, designed for the RHIC project. The program tracks as output to shared memory the central orbit, Twiss and dispersion functions, as well as the 6 x 6 beam hyperellipsoid. Transfer matrices between elements are available via interactive requests. Using a 6-d model, optical elements are modeled with a linear transfer matrix and a vector. The vector allows simulation of misalignments, shifts in field strengths, and beam rigidity. Currently only a linear model is used for elements. In addition to the usual magnets, a foil element is included which can shift the beam's rigidity (resulting from a change of charge and energy loss), as well as increase the momentum spread and emittance. Running as a Glish client, bl can be interfaced to other programs, such as an orbit plotter and a power supply application to give a quick prediction of the beam orbit from actual operating currents in the accelerator. Various strengths and offsets may be changed by sending Glish events to bl

  5. Interleaving of beam lines inside the PS tunnel

    CERN Multimedia

    1983-01-01

    View against the direction of the proton beams. The PS ring (section 26) is on the left. The injection tunnel for LEAR leaving from here has increased the trafic in this already busy area where the two Linacs and the transfer tunnel leading to the SPS, ISR and AA join the PS ring (cf. photo 7802260, 7802261, Annual Report 1981, p. 89, fig. 12).

  6. BEAM EXTRACTION FROM THE RECYCLER RING TO P1 LINE AT FERMILAB

    Energy Technology Data Exchange (ETDEWEB)

    Xiao, M. [Fermilab; Capista, D. [Fermilab; Adams, P. [Fermilab; Morris, D. [Fermilab; Yang, M. J. [Fermilab; Hazewood, K. [Fermilab

    2016-10-03

    The transfer line for beam extraction from the Recycler ring to P1 line provides a way to deliver 8 GeV kinetic energy protons from the Booster to the Delivery ring, via the Recycler, using existing beam transport lines, and without the need for new civil construction. It was designed in 2012. The kicker magnets at RR520 and the lambertson magnet at RR522 in the RR were installed in 2014 Summer Shutdown, the elements of RR to P1 Stub (permanent quads, trim quads, correctors, BPMs, the toroid at 703 and vertical bending dipole at V703 (ADCW) were installed in 2015 Summer Shutdown. On Tuesday, June 21, 2016, beam line from the Recycler Ring to P1 line was commissioned. The detailed results will be presented in this report.

  7. Ion spectroscopy for improvement of the physical beam model for therapy planning in ion beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Arico, Giulia

    2016-11-23

    Helium and carbon ions enable a more conformal dose distribution, narrower penumbra and higher relative biological effectiveness than photon and proton radiotherapy. However, they may undergo nuclear fragmentation in the patient tissues and the arising secondary fragments affect the delivered biological dose distributions. Currently there is a lack of data regarding ion nuclear fragmentation. One reason is the large size (up to some meters) of the experimental setups required for the investigations. In this thesis a new method is presented, which makes use of versatile pixelated semiconductor detectors (Timepix). This method is based on tracking of single particles and pattern recognition of their signals in the detectors. Measurements were performed at the HIT facility. The mixed radiation field arising from 430 MeV/u carbon ion beams and 221 MeV/u helium ion beams in water and in PMMA targets was investigated. The amounts of primary (carbon or helium) ions detected behind targets with the same water equivalent thickness (WET) were found to be in agreement within the statistical uncertainties. However, more fragments (differences up to 20% in case of H) and narrower lateral particle distributions were measured behind the PMMA than the water targets. The spectra of ions behind tissue surrogates and corresponding water targets with the same WET were analysed. The results obtained with adipose and inner bone surrogates and with the equivalent water phantoms were found to be consistent within the uncertainties. Significant differences in the results were observed in the case of lung and cortical bone surrogates when compared to the water phantoms. The experimental results were compared to FLUKA Monte Carlo simulations. This comparison could contribute to enhance the ion interaction models currently implemented for {sup 12}C and {sup 4}He ion beams.

  8. Status of the Medaustron Ion Beam Therapy centre

    CERN Document Server

    Dorda, U; Osmic, F; Benedikt, M

    2012-01-01

    MedAustron is a synchrotron based light-ion beam therapy centre for cancer treatment as well as for clinical and non-clinical research currently in its construction phase. The accelerator design is based on the CERN-PIMMS study and its technical implementation by CNAO. This paper presents a status overview over the whole project detailing the achieved progress of the building construction & technical infrastructure installation in Wiener Neustadt, Austria, as well as of the accelerator development, performed at CERN and partially at PSI. The design and procurement status and future planning of the various accelerator components is elaborated.

  9. Alanine EPR dosimeter response in proton therapy beams

    International Nuclear Information System (INIS)

    Gall, K.; Serago, C.; Desrosiers, M.; Bensen, D.

    1997-01-01

    We report a series of measurements directed to assess the suitability of alanine as a mailable dosimeter for dosimetry quality assurance of proton radiation therapy beams. These measurements include dose-response of alanine at 140 MeV, and comparison of response vs energy with a parallel plate ionization chamber. All irradiations were made at the Harvard Cyclotron Laboratory, and the dosimeters were read at NIST. The results encourage us that alanine could be expected to serve as a mailable dosimeter with systematic error due to differential energy response no greater than 3% when doses of 25 Gy are used. (Author)

  10. Design and Construction of a Beam Position Monitor Prototype for the Test Beam Line of the CTF3

    CERN Document Server

    Garcia Garrigos, Juan Jose

    2008-01-01

    A prototype of Beam Position Monitor (BPM) for the Test Beam Line (TBL) of the 3rd CLIC Test Facility (CTF3) at CERN has been designed and constructed at IFIC in collaboration with the CERN CTF3 team. The design is a scaled version of the BPMs of the CTF3 linac. The design goals are a resolution of 5 μm, an overall precision of 50 μm, in a circular vacuum chamber of 24 mm, in a frequency bandwidth between 10 kHz and 100MHz.The BPMis an inductive type BPM. Beam positions are derived from the image current created by a high frequency electron bunch beam into four electrodes surrounding the vacuum chamber. In this work we describe the mechanical design and construction, the description of the associated electronics together with the first calibration measurements performed in a wire test bench at CERN.

  11. Second-line failure and first experience with third-line antiretroviral therapy in Mumbai, India

    Directory of Open Access Journals (Sweden)

    Samsuddin Khan

    2014-07-01

    Full Text Available Background: There are limited data on the failure of second-line antiretroviral therapy (ART and the use of third-line ART in people living with HIV in resource-limited settings. Since 2011, the Médecins Sans Frontières (MSF HIV/tuberculosis programme in Mumbai, India, has been providing third-line ART to patients in care. Objective: To describe the experiences and programmatic challenges during management of suspected second-line ART failure and third-line ART therapy for patients living with HIV, including the use of HIV viral load (VL testing. Design: This was a retrospective, observational cohort study of patients with suspected second-line ART treatment failure, who were followed for at least 12 months between January 2011 and March 2014. Results: A total of 47 patients with suspected second-line failure met the inclusion criteria during the study period. Twenty-nine of them (62% responded to enhanced adherence support, had a subsequent undetectable VL after a median duration of 3 months and remained on second-line ART. The other 18 patients had to be initiated on a third-line ART regimen, which consisted of darunavir–ritonavir, raltegravir, and one or more appropriate nucleoside or nucleotide reverse transcriptase inhibitors, based on the results of HIV genotype testing. Of the 13 patients for whom follow-up VL results were available, 11 achieved virological suppression after a median duration of 3 months on third-line ART (interquartile range: 2.5–3.0. No serious treatment-related adverse events were recorded. Conclusions: With intensive counselling and adherence support in those suspected of failing second-line ART, unnecessary switching to more expensive third-line ART can be averted in the majority of cases. However, there is an increasing need for access to third-line ART medications such as darunavir and raltegravir, for which national ART programmes should be prepared. The cost of such medications and inadequate access to VL

  12. Expanding options in radiation oncology: neutron beam therapy

    International Nuclear Information System (INIS)

    Cohen, L.

    1982-01-01

    Twelve years experience with neutron beam therapy in Britain, the USA, Europe and Japan shows that local control is achievable in late-stage epidermoid cancer somewhat more frequently than with conventional radiotherapy. Tumours reputed to be radioresistant (salivary gland, bladder, rectosigmoid, melanoma, bone and soft-tissue sarcomas) have proved to be particularly responsive to neutrons. Pilot studies in brain and pancreatic tumours suggest promising new approaches to management of cancer in these sites. The availability of neutron therapy in the clinical environment opens new prospects for irradiation of 'radioresistant' tumours, permits more conservative cancer surgery, expands the use of elective chemotherapy and provides a wider range of options for cancer patients. (author)

  13. Improving Outcomes for Esophageal Cancer using Proton Beam Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Chuong, Michael D. [Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, Maryland (United States); Hallemeier, Christopher L. [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Jabbour, Salma K. [Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey (United States); Yu, Jen; Badiyan, Shahed [Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, Maryland (United States); Merrell, Kenneth W. [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Mishra, Mark V. [Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, Maryland (United States); Li, Heng [Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Verma, Vivek [Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska (United States); Lin, Steven H., E-mail: shlin@mdanderson.org [Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)

    2016-05-01

    Radiation therapy (RT) plays an essential role in the management of esophageal cancer. Because the esophagus is a centrally located thoracic structure there is a need to balance the delivery of appropriately high dose to the target while minimizing dose to nearby critical structures. Radiation dose received by these critical structures, especially the heart and lungs, may lead to clinically significant toxicities, including pneumonitis, pericarditis, and myocardial infarction. Although technological advancements in photon RT delivery like intensity modulated RT have decreased the risk of such toxicities, a growing body of evidence indicates that further risk reductions are achieved with proton beam therapy (PBT). Herein we review the published dosimetric and clinical PBT literature for esophageal cancer, including motion management considerations, the potential for reirradiation, radiation dose escalation, and ongoing esophageal PBT clinical trials. We also consider the potential cost-effectiveness of PBT relative to photon RT.

  14. Beam Line and Associated Work: Operational Phase 1985-1987

    Science.gov (United States)

    1988-08-26

    ENEA FEL experiment. F. Cicci, E. Fiorentino. A. Ranieri, E. Sabie. Centro Ricerche Energia Frascati (Italy?. ....................... 169 582.25...C) knife-edge pinhole bracket (cf. Fig. 14); (D) beam stop; (E) calorimeter with an attached Si solar cell detector; (F) paddle with tilted platforms...used for T real-time signal pickup behind the slit was a standard Si solar cell, epoxied to the calorimeter case (detail . in Fig. 5). The experimental

  15. Optimum steering of photon beam lines in SPEAR

    International Nuclear Information System (INIS)

    Corbett, W.J.; Fong, B.; Lee, M.; Ziemann, V.

    1993-04-01

    A common operational requirement for many synchrotron light sources is to maintain steered photon beamlines with minimum corrector strength values. To solve this problem for SPEAR, we employed the Singular Value Decomposition (SVD) matrix-inversion technique to minimize corrector strengths while constraining the photon beamlines to remain on target. The result was a reduction in corrector strengths, yielding increased overhead for the photon-beam position feedback systems

  16. Emittance Measurements For Future LHC Beams Using The PS Booster Measurement Line

    CERN Document Server

    Abelleira, Jose; Mikulec, Bettina; Di Giovanni, Gian Piero; CERN. Geneva. ATS Department

    2017-01-01

    The CERN PS Booster measurement line contains three pairs of SEM grids separated by drift space that measures the beam size in both planes. The combined analysis of these grids allows calculating a value for the transverse beam emittances. The precision of such a measurement depends on the ratio of RMS beam size and wire spacing. Within the LIU-PSB upgrade the extraction kinetic energy of the PSB will be increased from the current 1.4 GeV to 2.0 GeV. This will result in smaller transverse beam sizes for some of the future beams. The present layout of the transverse emittance measurement line is reviewed to verify if it will satisfy future requirements.

  17. Design study of the ESS-Bilbao 50 MeV proton beam line for radiobiological studies

    Energy Technology Data Exchange (ETDEWEB)

    Huerta-Parajon, M., E-mail: mhuerta@essbilbao.org; Martinez-Ballarin, R., E-mail: rmartinez@essbilbao.org; Abad, E., E-mail: eabad@essbilbao.org

    2015-02-01

    The ESS-Bilbao proton accelerator facility has been designed fulfilling the European Spallation Source (ESS) specifications to serve as the Spanish contribution to the ESS construction. Furthermore, several applications of the ESS-Bilbao proton beam are being considered in order to contribute to the knowledge in the field of radiobiology, materials and aerospace components. Understanding of the interaction of radiation with biological systems is of vital importance as it affects important applications such as cancer treatment with ion beam therapy among others. ESS-Bilbao plans to house a facility exclusively dedicated to radiobiological experiments with protons up to 50 MeV. Beam line design, optimisation and initial calculations of flux densities and absorbed doses were undertaken using the Monte Carlo simulation package FLUKA. A proton beam with a flux density of about 10{sup 6} protons/cm{sup 2} s reaches the water sample with a flat lateral distribution of the dose. The absorbed dose at the pristine Bragg peak calculated with FLUKA is 2.4 ± 0.1 Gy in 1 min of irradiation time. This value agrees with the clinically meaningful dose rates, i.e. around 2 Gy/min, used in hadrontherapy. Optimisation and validation studies in the ESS-Bilbao line for radiobiological experiments are detailed in this article.

  18. Cutaneous complication after electron beam therapy in breast cancer

    Directory of Open Access Journals (Sweden)

    M Jalilian

    2005-11-01

    Full Text Available Background: Breast cancer is the most common cancer in women and the second cause of death among them. There are several treatment methods for breast cancer, one of which is radiation therapy. There are two important methods of radiation therapy: tangential field and single oppositional field. Main goal of this study is evaluation of factors that have a role in producing acute side effects such as skin burning in breast cancer patients treated by electron beam,in order to decrease these side effects. Methods: From 1/2003 through 7/2004, 200 consecutive patients were evaluated during 18 months in seid-al-shohad hospital, whose mean age was 49 years old. In this study a questionnaire was used including some questions about personal profile such as patient's name, address, registration number, age and some other factors. All patients who were candidated to enter in this investigation filled out the questionnaire at the end of radiation therapy. The patients were examined and their skin burning grades were evaluated by RTOG scale. Data were analyzed by chi-square test using SPSS 11 software. Results: None of patients showed grades O or 4 of burning. 31.5 % of Patients showed grade 1, 64.5 % showed grade 2, 4 % showed grade 3 of burning. There was statistically significant correlation between posterior axillary field and skin burning and there wasnot any meaning between the other factors. Conclusion: It is necessary to pay more attention to posterior axillary field planning including field size, location, photon energy, depth and dose of treatment. Keywords: breast cancer, electron beam radiation therapy, skin burning

  19. Status of the ELIMED multidisciplinary and medical beam-line at ELI-Beamlines

    International Nuclear Information System (INIS)

    Romano, F; Cirrone, G A P; Cuttone, G; Schillaci, F; Scuderi, V; Amico, A; Candiano, G; Larosa, G; Leanza, R; Manna, R; Marchese, V; Milluzzo, G; Petringa, G; Pipek, J; Giordanengo, S; Guarachi, L F; Marchetto, F; Sacchi, R; Korn, G; Margarone, D

    2017-01-01

    Nowadays, one of the biggest challenges consists in using high intensity laser-target interaction to generate high-energy ions for medical purposes, eventually replacing the old paradigm of acceleration characterized by huge and complex machines. In order to investigate the feasibility of using laser-driven ion beams for multidisciplinary application, a dedicated beam transport line will be installed at the ELI-Beamlines facility in Prague (CZ), as a part of the User-oriented ELIMAIA beam-line dedicated to ion acceleration and their potential applications. The beam-line section dedicated to transport and dosimetric endpoints is called ELIMED (ELI-Beamlines MEDical and multidisciplinary applications) and will be developed by the INFN-LNS. (paper)

  20. Energy Deposition in Adjacent LHC Superconducting Magnets from Beam Loss at LHC Transfer Line Collimators

    CERN Document Server

    Beavan, S; Kain, V

    2006-01-01

    Injection intensities for the LHC are over an order of magnitude above the damage threshold. The collimation system in the two transfer lines is designed to dilute the beam sufficiently to avoid damage in case of accidental beam loss or mis-steered beam. To maximise the protection for the LHC most of the collimators are located in the last 300 m upstream of the injection point where the transfer lines approach the LHC machine. To study the issue of possible quenches following beam loss at the collimators part of the collimation section in one of the lines, TI 8, together with the adjacent part of the LHC has been modeled in FLUKA. The simulated energy deposition in the LHC for worst-case accidental losses and as well as for losses expected during a normal filling is presented.

  1. A large area diamond-based beam tagging hodoscope for ion therapy monitoring

    Science.gov (United States)

    Gallin-Martel, M.-L.; Abbassi, L.; Bes, A.; Bosson, G.; Collot, J.; Crozes, T.; Curtoni, S.; Dauvergne, D.; De Nolf, W.; Fontana, M.; Gallin-Martel, L.; Hostachy, J.-Y.; Krimmer, J.; Lacoste, A.; Marcatili, S.; Morse, J.; Motte, J.-F.; Muraz, J.-F.; Rarbi, F. E.; Rossetto, O.; Salomé, M.; Testa, É.; Vuiart, R.; Yamouni, M.

    2018-01-01

    The MoniDiam project is part of the French national collaboration CLaRyS (Contrôle en Ligne de l'hAdronthérapie par RaYonnements Secondaires) for on-line monitoring of hadron therapy. It relies on the imaging of nuclear reaction products that is related to the ion range. The goal here is to provide large area beam detectors with a high detection efficiency for carbon or proton beams giving time and position measurement at 100 MHz count rates (beam tagging hodoscope). High radiation hardness and intrinsic electronic properties make diamonds reliable and very fast detectors with a good signal to noise ratio. Commercial Chemical Vapor Deposited (CVD) poly-crystalline, heteroepitaxial and monocrystalline diamonds were studied. Their applicability as a particle detector was investigated using α and β radioactive sources, 95 MeV/u carbon ion beams at GANIL and 8.5 keV X-ray photon bunches from ESRF. This facility offers the unique capability of providing a focused ( 1 μm) beam in bunches of 100 ps duration, with an almost uniform energy deposition in the irradiated detector volume, therefore mimicking the interaction of single ions. A signal rise time resolution ranging from 20 to 90 ps rms and an energy resolution of 7 to 9% were measured using diamonds with aluminum disk shaped surface metallization. This enabled us to conclude that polycrystalline CVD diamond detectors are good candidates for our beam tagging hodoscope development. Recently, double-side stripped metallized diamonds were tested using the XBIC (X Rays Beam Induced Current) set-up of the ID21 beamline at ESRF which permits us to evaluate the capability of diamond to be used as position sensitive detector. The final detector will consist in a mosaic arrangement of double-side stripped diamond sensors read out by a dedicated fast-integrated electronics of several hundreds of channels.

  2. Defocusing beam line design for an irradiation facility at the TAEA SANAEM Proton Accelerator Facility

    CERN Document Server

    Gencer, A.; Efthymiopoulos, I.; Yiğitoğlu, M.

    2016-01-01

    Electronic components must be tested to ensure reliable performance in high radiation environments such as Hi-Limu LHC and space. We propose a defocusing beam line to perform proton irradiation tests in Turkey. The Turkish Atomic Energy Authority SANAEM Proton Accelerator Facility was inaugurated in May 2012 for radioisotope production. The facility has also an R&D room for research purposes. The accelerator produces protons with 30 MeV kinetic energy and the beam current is variable between View the MathML source10μA and View the MathML source1.2mA. The beam kinetic energy is suitable for irradiation tests, however the beam current is high and therefore the flux must be lowered. We plan to build a defocusing beam line (DBL) in order to enlarge the beam size, reduce the flux to match the required specifications for the irradiation tests. Current design includes the beam transport and the final focusing magnets to blow up the beam. Scattering foils and a collimator is placed for the reduction of the beam ...

  3. Defocusing beam line design for an irradiation facility at the TAEA SANAEM Proton Accelerator Facility

    Science.gov (United States)

    Gencer, A.; Demirköz, B.; Efthymiopoulos, I.; Yiğitoğlu, M.

    2016-07-01

    Electronic components must be tested to ensure reliable performance in high radiation environments such as Hi-Limu LHC and space. We propose a defocusing beam line to perform proton irradiation tests in Turkey. The Turkish Atomic Energy Authority SANAEM Proton Accelerator Facility was inaugurated in May 2012 for radioisotope production. The facility has also an R&D room for research purposes. The accelerator produces protons with 30 MeV kinetic energy and the beam current is variable between 10 μA and 1.2 mA. The beam kinetic energy is suitable for irradiation tests, however the beam current is high and therefore the flux must be lowered. We plan to build a defocusing beam line (DBL) in order to enlarge the beam size, reduce the flux to match the required specifications for the irradiation tests. Current design includes the beam transport and the final focusing magnets to blow up the beam. Scattering foils and a collimator is placed for the reduction of the beam flux. The DBL is designed to provide fluxes between 107 p /cm2 / s and 109 p /cm2 / s for performing irradiation tests in an area of 15.4 cm × 21.5 cm. The facility will be the first irradiation facility of its kind in Turkey.

  4. Image quality improvement in megavoltage cone beam CT using an imaging beam line and a sintered pixelated array system

    International Nuclear Information System (INIS)

    Breitbach, Elizabeth K.; Maltz, Jonathan S.; Gangadharan, Bijumon; Bani-Hashemi, Ali; Anderson, Carryn M.; Bhatia, Sudershan K.; Stiles, Jared; Edwards, Drake S.; Flynn, Ryan T.

    2011-01-01

    Purpose: To quantify the improvement in megavoltage cone beam computed tomography (MVCBCT) image quality enabled by the combination of a 4.2 MV imaging beam line (IBL) with a carbon electron target and a detector system equipped with a novel sintered pixelated array (SPA) of translucent Gd 2 O 2 S ceramic scintillator. Clinical MVCBCT images are traditionally acquired with the same 6 MV treatment beam line (TBL) that is used for cancer treatment, a standard amorphous Si (a-Si) flat panel imager, and the Kodak Lanex Fast-B (LFB) scintillator. The IBL produces a greater fluence of keV-range photons than the TBL, to which the detector response is more optimal, and the SPA is a more efficient scintillator than the LFB. Methods: A prototype IBL + SPA system was installed on a Siemens Oncor linear accelerator equipped with the MVision TM image guided radiation therapy (IGRT) system. A SPA strip consisting of four neighboring tiles and measuring 40 cm by 10.96 cm in the crossplane and inplane directions, respectively, was installed in the flat panel imager. Head- and pelvis-sized phantom images were acquired at doses ranging from 3 to 60 cGy with three MVCBCT configurations: TBL + LFB, IBL + LFB, and IBL + SPA. Phantom image quality at each dose was quantified using the contrast-to-noise ratio (CNR) and modulation transfer function (MTF) metrics. Head and neck, thoracic, and pelvic (prostate) cancer patients were imaged with the three imaging system configurations at multiple doses ranging from 3 to 15 cGy. The systems were assessed qualitatively from the patient image data. Results: For head and neck and pelvis-sized phantom images, imaging doses of 3 cGy or greater, and relative electron densities of 1.09 and 1.48, the CNR average improvement factors for imaging system change of TBL + LFB to IBL + LFB, IBL + LFB to IBL + SPA, and TBL + LFB to IBL + SPA were 1.63 (p -8 ), 1.64 (p -13 ), 2.66 (p -9 ), respectively. For all imaging doses, soft tissue contrast was more

  5. The Joint Structural Biology Group beam lines at the ESRF: Modern macromolecular crystallography

    CERN Document Server

    Mitchell, E P

    2001-01-01

    Macromolecular crystallography has evolved considerably over the last decade. Data sets in under an hour are now possible on high throughput beam lines leading to electron density and, possibly, initial models calculated on-site. There are five beam lines currently dedicated to macromolecular crystallography: the ID14 complex and BM-14 (soon to be superseded by ID-29). These lines handle over five hundred projects every six months and demand is increasing. Automated sample handling, alignment and data management protocols will be required to work efficiently with this demanding load. Projects developing these themes are underway within the JSBG.

  6. Beam tests on a proton linac booster for hadron therapy

    CERN Document Server

    De Martinis, C; Berra, P; Birattari, C; Calabretta, L; Crandall, K; Giove, D; Masullo, M R; Mauri, M; Rosso, E; Rovelli, A; Serafini, L; Szeless, Balázs; Toet, D Z; Vaccaro, Vittorio G; Weiss, M; Zennaro, R

    2002-01-01

    LIBO is a 3 GHz modular side-coupled proton linac booster designed to deliver beam energies up to 200 MeV, as required for the therapy of deep seated tumours. The injected beam of 50 to 70 MeV is produced by a cyclotron like those in several hospitals and research institutes. A full-scale prototype of the first module with an input/output energy of 62/74 MeV, respectively, was designed and built in 1999 and 2000. Full power RF tests were carried out successfully at CERN using a test facility at LIL at the end of the year 2000. In order to prove the feasibility of the acceleration process, an experimental setup with this module was installed at the INFN Laboratorio Nazionale del Sud (LNS) in Catania during 2001. The superconducting cyclotron provided the 62 MeV test beam. A compact solid-state RF modulator with a 4 MW klystron, made available by IBA-Scanditronix, was put into operation to power the linac. In this paper the main features of the accelerator are reviewed and the experimental results obtained duri...

  7. A beam monitor based on MPGD detectors for hadron therapy

    Directory of Open Access Journals (Sweden)

    Altieri P. R.

    2018-01-01

    Full Text Available Remarkable scientific and technological progress during the last years has led to the construction of accelerator based facilities dedicated to hadron therapy. This kind of technology requires precise and continuous control of position, intensity and shape of the ions or protons used to irradiate cancers. Patient safety, accelerator operation and dose delivery should be optimized by a real time monitoring of beam intensity and profile during the treatment, by using non-destructive, high spatial resolution detectors. In the framework of AMIDERHA (AMIDERHA - Enhanced Radiotherapy with HAdron project funded by the Ministero dell’Istruzione, dell’Università e della Ricerca (Italian Ministry of Education and Research the authors are studying and developing an innovative beam monitor based on Micro Pattern Gaseous Detectors (MPDGs characterized by a high spatial resolution and rate capability. The Monte Carlo simulation of the beam monitor prototype was carried out to optimize the geometrical set up and to predict the behavior of the detector. A first prototype has been constructed and successfully tested using 55Fe, 90Sr and also an X-ray tube. Preliminary results on both simulations and tests will be presented.

  8. Quantitative analysis of beam delivery parameters and treatment process time for proton beam therapy

    International Nuclear Information System (INIS)

    Suzuki, Kazumichi; Gillin, Michael T.; Sahoo, Narayan; Zhu, X. Ronald; Lee, Andrew K.; Lippy, Denise

    2011-01-01

    Purpose: To evaluate patient census, equipment clinical availability, maximum daily treatment capacity, use factor for major beam delivery parameters, and treatment process time for actual treatments delivered by proton therapy systems. Methods: The authors have been recording all beam delivery parameters, including delivered dose, energy, range, spread-out Bragg peak widths, gantry angles, and couch angles for every treatment field in an electronic medical record system. We analyzed delivery system downtimes that had been recorded for every equipment failure and associated incidents. These data were used to evaluate the use factor of beam delivery parameters, the size of the patient census, and the equipment clinical availability of the facility. The duration of each treatment session from patient walk-in and to patient walk-out of the treatment room was measured for 82 patients with cancers at various sites. Results: The yearly average equipment clinical availability in the last 3 yrs (June 2007-August 2010) was 97%, which exceeded the target of 95%. Approximately 2200 patients had been treated as of August 2010. The major disease sites were genitourinary (49%), thoracic (25%), central nervous system (22%), and gastrointestinal (2%). Beams have been delivered in approximately 8300 treatment fields. The use factor for six beam delivery parameters was also evaluated. Analysis of the treatment process times indicated that approximately 80% of this time was spent for patient and equipment setup. The other 20% was spent waiting for beam delivery and beam on. The total treatment process time can be expressed by a quadratic polynomial of the number of fields per session. The maximum daily treatment capacity of our facility using the current treatment processes was estimated to be 133 ± 35 patients. Conclusions: This analysis shows that the facility has operated at a high performance level and has treated a large number of patients with a variety of diseases. The use

  9. Chemical investigations of isotope separation on line target units for carbon and nitrogen beams

    CERN Document Server

    Franberg, H; Gäggeler, H W; Köster, U

    2006-01-01

    Radioactive ion beams (RIBs) are of significant interest in a number of applications. Isotope separation on line (ISOL) facilities provide RIB with high beam intensities and good beam quality. An atom that is produced within the ISOL target will first diffuse out from the target material. During the effusion towards the transfer line and into the ion source the many contacts with the surrounding surfaces may cause unacceptable delays in the transport and, hence, losses of the shorter-lived isotopes. We performed systematic chemical investigations of adsorption in a temperature and concentration regime relevant for ISOL targets and ion source units, with regard to CO/sub x/ and NOmaterials are potential construction materials for the above-mentioned areas. Off-line and on-line tests have been performed using a gas thermochromatography setup with radioactive tracers. The experiments were performed at the production of tracers for atmospheric chemistry (PROTRAC) facility at the Paul Schener Institute in Villigen...

  10. Preliminary results of an in-beam PET prototype for proton therapy

    International Nuclear Information System (INIS)

    Attanasi, F.; Belcari, N.; Camarda, M.; Cirrone, G.A.P.; Cuttone, G.; Del Guerra, A.; Di Rosa, F.; Lanconelli, N.; Rosso, V.; Russo, G.; Vecchio, S.

    2008-01-01

    Proton therapy can overcome the limitations of conventional radiotherapy due to the more selective energy deposition in depth and to the increased biological effectiveness. Verification of the delivered dose is desirable, but the complete stopping of the protons in patient prevents the application of electronic portal imaging methods that are used in conventional radiotherapy During proton therapy β + emitters like 11 C, 15 O, 10 C are generated in irradiated tissues by nuclear reactions. The measurement of the spatial distribution of this activity, immediately after patient irradiation, can lead to information on the effective delivered dose. First, results of a feasibility study of an in-beam PET for proton therapy are reported. The prototype is based on two planar heads with an active area of about 5x5 cm 2 . Each head is made up of a position sensitive photomultiplier coupled to a square matrix of same size of LYSO scintillating crystals (2x2x18 mm 3 pixel dimensions). Four signals from each head are acquired through a dedicated electronic board that performs signal amplification and digitization. A 3D reconstruction of the activity distribution is calculated using an expectation maximization algorithm. To characterize the PET prototype, the detection efficiency and the spatial resolution were measured using a point-like radioactive source. The validation of the prototype was performed using 62 MeV protons at the CATANA beam line of INFN LNS and PMMA phantoms. Using the full energy proton beam and various range shifters, a good correlation between the position of the activity distal edge and the thickness of the beam range shifter was found along the axial direction

  11. Preliminary results of an in-beam PET prototype for proton therapy

    Science.gov (United States)

    Attanasi, F.; Belcari, N.; Camarda, M.; Cirrone, G. A. P.; Cuttone, G.; Del Guerra, A.; Di Rosa, F.; Lanconelli, N.; Rosso, V.; Russo, G.; Vecchio, S.

    2008-06-01

    Proton therapy can overcome the limitations of conventional radiotherapy due to the more selective energy deposition in depth and to the increased biological effectiveness. Verification of the delivered dose is desirable, but the complete stopping of the protons in patient prevents the application of electronic portal imaging methods that are used in conventional radiotherapy During proton therapy β + emitters like 11C, 15O, 10C are generated in irradiated tissues by nuclear reactions. The measurement of the spatial distribution of this activity, immediately after patient irradiation, can lead to information on the effective delivered dose. First, results of a feasibility study of an in-beam PET for proton therapy are reported. The prototype is based on two planar heads with an active area of about 5×5 cm 2. Each head is made up of a position sensitive photomultiplier coupled to a square matrix of same size of LYSO scintillating crystals (2×2×18 mm 3 pixel dimensions). Four signals from each head are acquired through a dedicated electronic board that performs signal amplification and digitization. A 3D reconstruction of the activity distribution is calculated using an expectation maximization algorithm. To characterize the PET prototype, the detection efficiency and the spatial resolution were measured using a point-like radioactive source. The validation of the prototype was performed using 62 MeV protons at the CATANA beam line of INFN LNS and PMMA phantoms. Using the full energy proton beam and various range shifters, a good correlation between the position of the activity distal edge and the thickness of the beam range shifter was found along the axial direction.

  12. Preliminary results of an in-beam PET prototype for proton therapy

    Energy Technology Data Exchange (ETDEWEB)

    Attanasi, F.; Belcari, N.; Camarda, M. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy); Cirrone, G.A.P.; Cuttone, G. [INFN Laboratori Nazionali del Sud, Catania (Italy); Del Guerra, A. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy); Di Rosa, F. [INFN Laboratori Nazionali del Sud, Catania (Italy); Lanconelli, N. [Department of Physics, University of Bologna and INFN Sezione di Bologna, Bologna (Italy); Rosso, V. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy)], E-mail: valeria.rosso@pi.infn.it; Russo, G. [INFN Laboratori Nazionali del Sud, Catania (Italy); Vecchio, S. [Department of Physics, University of Pisa and INFN Sezione di Pisa, Pisa (Italy)

    2008-06-11

    Proton therapy can overcome the limitations of conventional radiotherapy due to the more selective energy deposition in depth and to the increased biological effectiveness. Verification of the delivered dose is desirable, but the complete stopping of the protons in patient prevents the application of electronic portal imaging methods that are used in conventional radiotherapy During proton therapy {beta}{sup +} emitters like {sup 11}C, {sup 15}O, {sup 10}C are generated in irradiated tissues by nuclear reactions. The measurement of the spatial distribution of this activity, immediately after patient irradiation, can lead to information on the effective delivered dose. First, results of a feasibility study of an in-beam PET for proton therapy are reported. The prototype is based on two planar heads with an active area of about 5x5 cm{sup 2}. Each head is made up of a position sensitive photomultiplier coupled to a square matrix of same size of LYSO scintillating crystals (2x2x18 mm{sup 3} pixel dimensions). Four signals from each head are acquired through a dedicated electronic board that performs signal amplification and digitization. A 3D reconstruction of the activity distribution is calculated using an expectation maximization algorithm. To characterize the PET prototype, the detection efficiency and the spatial resolution were measured using a point-like radioactive source. The validation of the prototype was performed using 62 MeV protons at the CATANA beam line of INFN LNS and PMMA phantoms. Using the full energy proton beam and various range shifters, a good correlation between the position of the activity distal edge and the thickness of the beam range shifter was found along the axial direction.

  13. Treatment facilities, human resource development, and future prospect of particle beam therapy

    International Nuclear Information System (INIS)

    Tamaki, Tomoaki; Nakano, Takashi

    2015-01-01

    The number of particle beam therapy facilities is increasing globally. Among the countries practicing particle beam therapy, Japan is one of the leading countries in the field with four operating carbon-ion therapy facilities and ten operating proton therapy facilities. With the increasing number of particle beam therapy facilities, the human resource development is becoming extremely important, and there has been many such efforts including the Gunma University Program for Cultivating Global Leaders in Heavy Ion Therapeutics and Engineering, which aimed to educate and train the radiation oncologists, medical physicists, accelerator engineers, and radiation biologists to become global leaders in the field of particle beam therapy. In the future, the benefit and effectiveness of particle beam therapy should be discussed and elucidated objectively in a framework of comprehensive cancer care. (author)

  14. Proton beam characterization in the experimental room of the Trento Proton Therapy facility

    Science.gov (United States)

    Tommasino, F.; Rovituso, M.; Fabiano, S.; Piffer, S.; Manea, C.; Lorentini, S.; Lanzone, S.; Wang, Z.; Pasini, M.; Burger, W. J.; La Tessa, C.; Scifoni, E.; Schwarz, M.; Durante, M.

    2017-10-01

    As proton therapy is becoming an established treatment methodology for cancer patients, the number of proton centres is gradually growing worldwide. The economical effort for building these facilities is motivated by the clinical aspects, but might be also supported by the potential relevance for the research community. Experiments with high-energy protons are needed not only for medical physics applications, but represent also an essential part of activities dedicated to detector development, space research, radiation hardness tests, as well as of fundamental research in nuclear and particle physics. Here we present the characterization of the beam line installed in the experimental room of the Trento Proton Therapy Centre (Italy). Measurements of beam spot size and envelope, range verification and proton flux were performed in the energy range between 70 and 228 MeV. Methods for reducing the proton flux from typical treatments values of 106-109 particles/s down to 101-105 particles/s were also investigated. These data confirm that a proton beam produced in a clinical centre build by a commercial company can be exploited for a broad spectrum of experimental activities. The results presented here will be used as a reference for future experiments.

  15. Fast optimization and dose calculation in scanned ion beam therapy

    International Nuclear Information System (INIS)

    Hild, S.; Graeff, C.; Trautmann, J.; Kraemer, M.; Zink, K.; Durante, M.; Bert, C.

    2014-01-01

    Purpose: Particle therapy (PT) has advantages over photon irradiation on static tumors. An increased biological effectiveness and active target conformal dose shaping are strong arguments for PT. However, the sensitivity to changes of internal geometry complicates the use of PT for moving organs. In case of interfractionally moving objects adaptive radiotherapy (ART) concepts known from intensity modulated radiotherapy (IMRT) can be adopted for PT treatments. One ART strategy is to optimize a new treatment plan based on daily image data directly before a radiation fraction is delivered [treatment replanning (TRP)]. Optimizing treatment plans for PT using a scanned beam is a time consuming problem especially for particles other than protons where the biological effective dose has to be calculated. For the purpose of TRP, fast optimization and fast dose calculation have been implemented into the GSI in-house treatment planning system (TPS) TRiP98. Methods: This work reports about the outcome of a code analysis that resulted in optimization of the calculation processes as well as implementation of routines supporting parallel execution of the code. To benchmark the new features, the calculation time for therapy treatment planning has been studied. Results: Compared to the original version of the TPS, calculation times for treatment planning (optimization and dose calculation) have been improved by a factor of 10 with code optimization. The parallelization of the TPS resulted in a speedup factor of 12 and 5.5 for the original version and the code optimized version, respectively. Hence the total speedup of the new implementation of the authors' TPS yielded speedup factors up to 55. Conclusions: The improved TPS is capable of completing treatment planning for ion beam therapy of a prostate irradiation considering organs at risk in this has been overseen in the review process. Also see below 6 min

  16. Treatment of Head and Neck Paragangliomas With External Beam Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Dupin, Charles, E-mail: c.dupin@bordeaux.unicancer.fr [Department of Radiotherapy, Comprehensive Cancer Center, Institut Bergonié, Bordeaux (France); Lang, Philippe [Department of Radiotherapy, Pitié Salpétrière, Paris (France); Dessard-Diana, Bernadette [Department of Radiotherapy, Hopital Européen Georges Pompidou, Paris (France); Simon, Jean-Marc; Cuenca, Xavier; Mazeron, Jean-Jacques; Feuvret, Loïc [Department of Radiotherapy, Pitié Salpétrière, Paris (France)

    2014-06-01

    Purpose: To retrospectively assess the outcomes of radiation therapy in patients with head and neck paragangliomas. Methods and Materials: From 1990 to 2009, 66 patients with 81 head and neck paragangliomas were treated by conventional external beam radiation therapy in 25 fractions at a median dose of 45 Gy (range, 41.4-68 Gy). One case was malignant. The median gross target volume and planning target volume were 30 cm{sup 3} (range, 0.9-243 cm{sup 3}) and 116 cm{sup 3} (range, 24-731 cm{sup 3}), respectively. Median age was 57.4 years (range, 15-84 years). Eleven patients had multicentric lesions, and 8 had family histories of paraganglioma. Paragangliomas were located in the temporal bone, the carotid body, and the glomus vagal in 51, 18, and 10 patients, respectively. Forty-six patients had exclusive radiation therapy, and 20 had salvage radiation therapy. The median follow-up was 4.1 years (range, 0.1-21.2 years). Results: One patient had a recurrence of temporal bone paraganglioma 8 years after treatment. The actuarial local control rates were 100% at 5 years and 98.7% at 10 years. Patients with multifocal tumors and family histories were significantly younger (42 years vs 58 years [P=.002] and 37 years vs 58 years [P=.0003], respectively). The association between family predisposition and multifocality was significant (P<.001). Two patients had cause-specific death within the 6 months after irradiation. During radiation therapy, 9 patients required hospitalization for weight loss, nausea, mucositis, or ophthalmic zoster. Two late vascular complications occurred (middle cerebral artery and carotid stenosis), and 2 late radiation-related meningiomas appeared 15 and 18 years after treatment. Conclusion: Conventional external beam radiation therapy is an effective and safe treatment option that achieves excellent local control; it should be considered as a first-line treatment of choice for head and neck paragangliomas.

  17. Treatment of Head and Neck Paragangliomas With External Beam Radiation Therapy

    International Nuclear Information System (INIS)

    Dupin, Charles; Lang, Philippe; Dessard-Diana, Bernadette; Simon, Jean-Marc; Cuenca, Xavier; Mazeron, Jean-Jacques; Feuvret, Loïc

    2014-01-01

    Purpose: To retrospectively assess the outcomes of radiation therapy in patients with head and neck paragangliomas. Methods and Materials: From 1990 to 2009, 66 patients with 81 head and neck paragangliomas were treated by conventional external beam radiation therapy in 25 fractions at a median dose of 45 Gy (range, 41.4-68 Gy). One case was malignant. The median gross target volume and planning target volume were 30 cm 3 (range, 0.9-243 cm 3 ) and 116 cm 3 (range, 24-731 cm 3 ), respectively. Median age was 57.4 years (range, 15-84 years). Eleven patients had multicentric lesions, and 8 had family histories of paraganglioma. Paragangliomas were located in the temporal bone, the carotid body, and the glomus vagal in 51, 18, and 10 patients, respectively. Forty-six patients had exclusive radiation therapy, and 20 had salvage radiation therapy. The median follow-up was 4.1 years (range, 0.1-21.2 years). Results: One patient had a recurrence of temporal bone paraganglioma 8 years after treatment. The actuarial local control rates were 100% at 5 years and 98.7% at 10 years. Patients with multifocal tumors and family histories were significantly younger (42 years vs 58 years [P=.002] and 37 years vs 58 years [P=.0003], respectively). The association between family predisposition and multifocality was significant (P<.001). Two patients had cause-specific death within the 6 months after irradiation. During radiation therapy, 9 patients required hospitalization for weight loss, nausea, mucositis, or ophthalmic zoster. Two late vascular complications occurred (middle cerebral artery and carotid stenosis), and 2 late radiation-related meningiomas appeared 15 and 18 years after treatment. Conclusion: Conventional external beam radiation therapy is an effective and safe treatment option that achieves excellent local control; it should be considered as a first-line treatment of choice for head and neck paragangliomas

  18. Selection of carbon beam therapy: biophysical models of carbon beam therapy.

    Science.gov (United States)

    Matsufuji, Naruhiro

    2018-03-01

    Variation in the relative biological effectiveness (RBE) within the irradiation field of a carbon beam makes carbon-ion radiotherapy unique and advantageous in delivering the therapeutic dose to a deep-seated tumor, while sparing surrounding normal tissues. However, it is crucial to consider the RBE, not only in designing the dose distribution during treatment planning, but also in analyzing the clinical response retrospectively. At the National Institute of Radiological Sciences, the RBE model was established based on the response of human salivary gland cells. The response was originally handled with a linear-quadratic model, and later with a microdosimetric kinetic model. Retrospective analysis with a tumor-control probability model of non-small cell cancer treatment revealed a steep dose response in the tumor, and that the RBE of the tumor was adequately estimated using the model. A commonly used normal tissue complication probability model has not yet fully been accountable for the variable RBE of carbon ions; however, analysis of rectum injury after prostate cancer treatment suggested a highly serial-organ structure for the rectum, and a steep dose response similar to that observed for tumors.

  19. Impact of beam angle choice on pencil beam scanning breath-hold proton therapy for lung lesions

    DEFF Research Database (Denmark)

    Gorgisyan, Jenny; Perrin, Rosalind; Lomax, Antony J

    2017-01-01

    INTRODUCTION: The breath-hold technique inter alia has been suggested to mitigate the detrimental effect of motion on pencil beam scanned (PBS) proton therapy dose distributions. The aim of this study was to evaluate the robustness of incident proton beam angles to day-to-day anatomical variation...

  20. Improvements for extending the time between maintenance periods for the Heidelberg ion beam therapy center (HIT) ion sources

    Energy Technology Data Exchange (ETDEWEB)

    Winkelmann, Tim, E-mail: tim.winkelmann@med.uni-heidelberg.de; Cee, Rainer; Haberer, Thomas; Naas, Bernd; Peters, Andreas; Schreiner, Jochen [Heidelberger Ionenstrahl-Therapie Centrum (HIT), D -69120 Heidelberg (Germany)

    2014-02-15

    The clinical operation at the Heidelberg Ion Beam Therapy Center (HIT) started in November 2009; since then more than 1600 patients have been treated. In a 24/7 operation scheme two 14.5 GHz electron cyclotron resonance ion sources are routinely used to produce protons and carbon ions. The modification of the low energy beam transport line and the integration of a third ion source into the therapy facility will be shown. In the last year we implemented a new extraction system at all three sources to enhance the lifetime of extraction parts and reduce preventive and corrective maintenance. The new four-electrode-design provides electron suppression as well as lower beam emittance. Unwanted beam sputtering effects which typically lead to contamination of the insulator ceramics and subsequent high-voltage break-downs are minimized by the beam guidance of the new extraction system. By this measure the service interval can be increased significantly. As a side effect, the beam emittance can be reduced allowing a less challenging working point for the ion sources without reducing the effective beam performance. This paper gives also an outlook to further enhancements at the HIT ion source testbench.

  1. DOE/DMS workshop on future synchrotron VUV and x-ray beam Lines

    International Nuclear Information System (INIS)

    Green, P.H.

    1992-03-01

    This document contains an overview of the participating DOE Laboratory beam line interests and the projected science to be addressed on these beam lines, both at new and existing synchrotron facilities. The scientific programs associated with present and planned synchrotron research by DOE Laboratories are discussed in chapters titled ''VUV and Soft X-Ray Research'' and ''Hard X-Ray Research.'' This research encompasses a broad range of the nation's scientific and technical research needs from fundamental to applied, in areas including environmental, biological, and physical sciences; new materials; and energy-related technologies. The projected cost of this proposed construction has been provided in tabular form using a uniform format so that anticipated DOE and outside funding agency contributions for construction and for research and development can be determined. The cost figures are, of course, subject to uncertainties of detailed design requirements and the availability of facility-designed generic components and outside vendors. The report also contains a compendium (as submitted by the beam line proposers) of the design capabilities, the anticipated costs, and the scientific programs of projected beam line construction at the four synchrotron facilities. A summary of the projected cost of these beam lines to be requested of DOE is compiled

  2. The Challenge of Interfacing the Primary Beam Lines for the AWAKE Project at CERN

    CERN Document Server

    Bracco, C; Gschwendtner, E; Meddahi, M; Petrenko, A; Velotti, FM

    2014-01-01

    The Proton Driven Plasma Wakefield Acceleration Experiment (AWAKE) at CERN foresees the simultaneous operation of a proton, a laser and an electron beam. The first stage of the experiment will consist in proving the self-modulation, in the plasma, of a long proton bunch into micro-bunches. The success of this experiment requires an almost perfect concentricity of the proton and laser beam, over the full length of the plasma cell. The complexity of integrating the laser into the proton beam line and fulfilling the strict requirements in terms of pointing precision of the proton beam at the plasma cell are described. The second stage of the experiment foresees also the injection of electron bunches to probe the accelerating wakefields driven by the proton beam. Studies were performed to evaluate the possibility of injecting the electron beam parallel and with an offset to the beam axis. This option would imply that protons and electrons will have to share the last few meters of a common beam line. Issues and po...

  3. SU-F-T-137: Out-Of-Beam Dose for a Compact Double-Scattering Proton Beam Therapy System

    Energy Technology Data Exchange (ETDEWEB)

    Islam, M; Ahmad, S; Jin, H [University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States)

    2016-06-15

    Purpose: The out-of-beam dose is important for understanding the peripheral dose in radiation therapy. In proton radiotherapy, the study of out-of-beam dose is scarce and the treatment planning system (TPS) based on pencil beam algorithm cannot accurately predict the out-of-beam dose. This study investigates the out-of-beam dose for the single-room Mevion S250 double scattering proton therapy system using experimentally measured and treatment planning software generated data. The results are compared with those reported for conventional photon beam therapy. However, this study does not incorporate the neutron contribution in the scattered dose. Methods: A total of seven proton treatment plans were generated using Varian Eclipse TPS for three different sites (brain, lung, and pelvis) in an anthropomorphic phantom. Three field sizes of 5×5, 10×10, and 20×20 cm{sup 2} (lung only) with typical clinical range (13.3–22.8 g/cm{sup 2}) and modulation widths (5.3–14.0 g/cm{sup 2}) were used. A single beam was employed in each treatment plan to deliver a dose of 181.8 cGy (200.0 cGy (RBE)) to the selected target. The out-of-beam dose was measured at 2.0, 5.0, 10.0, and 15.0 cm from the beam edge in the phantom using a thimble chamber (PTW TN31010). Results: The out-of-beam dose generally increased with field size, range, and volume irradiated. For all the plans, the scattered dose sharply fell off with distance. At 2.0 cm, the out-of-beam dose ranged from 0.35% to 2.16% of the delivered dose; however, the dose was clinically negligible (<0.3%) at a distance of 5.0 cm and greater. In photon therapy, the slightly greater out-of-beam dose was reported (TG36; 4%, 2%, and 1% for 2.0, 5.0, and 10.0 cm, respectively, using 6 MV beam). Conclusion: The measured out-of-beam dose in proton therapy excluding neutron contribution was observed higher than the TPS calculated dose and comparable to that of photon beam therapy.

  4. Research advances in proton beam therapy for hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    DAI Shuyang

    2013-10-01

    Full Text Available Hepatocellular carcinoma (HCC, one of the most common malignancies with high prevalence and mortality rate, usually results in poor prognosis and limited survival. A comprehensive analysis on the number and location of tumors, Child-Pugh grade, and Barcelona Clinic Liver Cancer stage will help the development of suitable treatment programs and improve prediction of prognosis. A majority of patients are complicated by cirrhosis, enlarged tumor, multiple lesions, vascular invasion, and even cancer embolus in the portal vein. With the growth of knowledge about the radiation tolerance of normal tissue and the advances in radiotherapy techniques, radiotherapy has become an important tool for step-down therapy and adjuvant therapy for liver cancer. Proton beam therapy (PBT is emerging as a novel radiotherapy for the management of HCC, which, benefiting from the effect of Bragg Peak from PBT, effectively decreases the toxicity of traditional radiotherapies to the liver and does little harm to the uninvolved liver tissue or the surrounding structures while intensifying the destruction in targeted malignant lesions. Furthermore, several previous studies on the treatment of HCC with PBT revealed excellent local control. The distinctive biophysical attributes of PBT in the treatment of HCC, as well as the available literature regarding clinical outcomes and toxicity of using PBT for HCC, are reviewed. Current evidence provides limited indications for PBT, which suggests that further study on the relationship between liver function and PBT is required to gain further insight into its indication and standardization.

  5. Charged particle therapy with mini-segmented beams

    Directory of Open Access Journals (Sweden)

    F. Avraham eDilmanian

    2015-12-01

    Full Text Available One of the fundamental attributes of proton therapy and carbon ion therapy is the ability of these charged particles to spare tissue distal to the targeted tumor. This significantly reduces normal tissue toxicity and has the potential to translate to a wider therapeutic index. Although, in general, particle therapy also reduces dose to the proximal tissues, particularly in the vicinity of the target, dose to the skin and to other very superficial tissues tends to be higher than that of megavoltage x-rays. The methods presented here, namely Interleaved carbon minibeams and Radiosurgery with arrays of proton and light ion minibeams, both utilize beams segmented into arrays of parallel minibeams of about 0.3 mm incident beam size. These minibeam arrays spare tissues, as demonstrated by synchrotron x-ray experiments. An additional feature of particle minibeams is their gradual broadening due to multiple Coulomb scattering as they penetrate tissues. In the case of interleaved carbon minibeams, which do not broaden much, two arrays of planar carbon minibeams that remain parallel at target depth, are aimed at the target from 90º angles and made to interleave at the target to produce a solid radiation field within the target. As a result the surrounding tissues are exposed only to individual carbon minibeam arrays and are therefore spared. The method was used in four-directional geometry at the NASA Space Radiation Laboratory to ablate a 6.5-mm target in a rabbit brain at a single exposure with 40 Gy physical absorbed dose. Contrast-enhanced magnetic resonance imaging and histology six month later showed very focal target necrosis with nearly no damage to the surrounding brain. As for minibeams of protons and light ions, for which the minibeam broadening is substantial, measurements at MD Anderson Cancer Center in Houston, Texas, and Monte Carlo simulations showed that the broadening minibeams will merge with their neighbors at a certain tissue depth

  6. Insertion device and beam line plans for the Advanced Photon Source: A report and recommendations by the Insertion Device and Beam Line Planning Committee

    International Nuclear Information System (INIS)

    1988-02-01

    In the 7-GeV Advanced Photon Source (APS) Conceptual Design Report (CDR), fifteen complete experimental beam lines were specified in order to establish a representative technical and cost base for the components involved. In order to optimize the composition of the insertion devices and the beam line, these funds are considered a ''Trust Fund.'' The present report evaluates the optimization for the distribution of these funds so that the short- and long-term research programs will be most productive, making the facility more attractive from the user's point of view. It is recommended that part of the ''Trust Fund'' be used for the construction of the insertion devices, the front-end components, and the first-optics, minimizing the cost to potential users of completing a beam line. In addition, the possibility of cost savings resulting from replication and standardization of high multiplicity components (such as IDs, front ends, and first-optics instrumentation) is addressed. 2 refs., 5 tabs

  7. Beam current monitoring in the AGS Booster and its transfer lines

    International Nuclear Information System (INIS)

    Witkover, R.L.; Zitvogel, E.; Castillo, V.

    1991-01-01

    The new AGS Booster is designed to accelerate low intensity polarized protons and heavy ions, and high intensity protons. The wide range of beam parameters and the vacuum, thermal and radiation environment, presented challenges in the instrumentation design. This paper describes the problems and solutions for the beam current monitors in the Booster and its transport lines. Where available, results of the initial operation will be presented. 11 refs., 3 figs

  8. Dose distributions of a proton beam for eye tumor therapy: Hybrid pencil-beam ray-tracing calculations

    International Nuclear Information System (INIS)

    Rethfeldt, Ch.; Fuchs, H.; Gardey, K.-U.

    2006-01-01

    For the case of eye tumor therapy with protons, improvements are introduced compared to the standard dose calculation which implies straight-line optics and the constant-density assumption for the eye and its surrounding. The progress consists of (i) taking account of the lateral scattering of the protons in tissue by folding the entrance fluence distribution with the pencil beam distribution widening with growing depth in the tissue, (ii) rescaling the spread-out Bragg peak dose distribution in water with the radiological path length calculated voxel by voxel on ray traces through a realistic density matrix for the treatment geometry, yielding a trajectory dependence of the geometrical range. Distributions calculated for some specific situations are compared to measurements and/or standard calculations, and differences to the latter are discussed with respect to the requirements of therapy planning. The most pronounced changes appear for wedges placed in front of the eye, causing additional widening of the lateral falloff. The more accurate prediction of the dose dependence at the field borders is of interest with respect to side effects in the risk organs of the eye

  9. Materials research and beam line operation utilizing NSLS [National Synchrotron Light Source]: Progress report

    International Nuclear Information System (INIS)

    Liedl, G.L.

    1987-10-01

    MATRIX is a group of scientists who have common interests in utilizing x-ray synchrotron radiation for materials research. This group has developed a specialized beam line (X-18A) for x-ray scattering studies at the National Synchrotron Light Source (NSLS). The beam line was designed to optimize experimental conditions for diffuse scattering and surface/interface studies. An extension of diffuse scattering to provide better quantitative data has been shown as well as a unique application to the solution of the phase problem. In the x-ray surface scattering area the first reported experiment to illustrate the capabilities for studying monolayers on water was performed. Current beam line upgrade projects are also described. In addition to a change to a UHV system and improvements dictated by operational experience, two new systems are described, a unique small angle scattering chamber (SAXS) for dynamic studies of nucleation and growth and a surface scattering chamber. 5 figs

  10. Beam position monitoring in the AGS Linac to Booster transfer line

    International Nuclear Information System (INIS)

    Shea, T.J.; Brodowski, J.; Witkover, R.

    1991-01-01

    A beam position monitor system has been developed and used in the commissioning of Brookhaven's Linac to Booster transfer line. This line transports a chopped, RF modulated H- beam from the 200 MeV Linac to the AGS Booster. Over a 15dB dynamic range in beam current, the position monitor system provides a real-time, normalized position signal with an analog bandwidth of about 20 MHz. Seven directional coupler style pickups are installed in the line with each pickup sensing both horizontal and vertical position. Analog processing electronics are located in the tunnel and incorporate the amplitude modulation to phase modulation normalization technique. To avoid interference from the 200 MHz linac RF system, processing is performed at 400 MHz. This paper provides a system overview and report results from the commissioning experience

  11. 1 to 2 GeV/c beam line for hypernuclear and kaon research

    International Nuclear Information System (INIS)

    Chrien, R.E.

    1985-01-01

    A kaon beam line operating in the range from 1.0 to 2.0 GeV/c is proposed. The line is meant for kaon and pion research in a region hitherto inaccessible to experimenters. Topics in hypernuclear and kaon physics of high current interest include the investigation of doubly strange nuclear systems with the K - ,K + reaction, searching for dibaryon resonances, hyperon-nucleon interactions, hypernuclear γ rays, and associated production of excited hypernuclei. The beam line would provide separated beams of momentum analyzed kaons at intensities greater than 10 6 particles per spill with a momentum determined to one part in a thousand. This intensity is an order of magnitude greater than that currently available. 63 references

  12. Lattice design of medium energy beam transport line for n spallation neutron source

    International Nuclear Information System (INIS)

    Dhingra, Rinky; Kulkarni, Nita S.; Kumar, Vinit

    2015-01-01

    A 1 GeV H - injector linac is being designed at RRCAT for the proposed Indian Spallation Neutron Source (ISNS). The front-end of the injector linac will consist of Radiofrequency Quadrupole (RFQ) linac, which will accelerate the H - beam from 50 keV to 3 MeV. The beam will be further accelerated in superconducting Single Spoke Resonators (SSRs). A Medium Energy Beam Transport (MEBT) line will be used to transport the beam from the exit of RFQ to the input of SSR. The main purpose of MEBT is to carry out beam matching from RFQ to SSR, and beam chopping. In this paper, we describe the optimization criteria for the lattice design of MEBT. The optimized lattice element parameters are presented for zero and full (15 mA) current case. Beam dynamics studies have been carried out using an envelope tracing code Trace-3D. Required beam deflection angle due to the chopper housed inside the MEBT for beam chopping has also been estimated. (author)

  13. Successful beam test of the SPS-to-LHC transfer line TI2

    CERN Multimedia

    2007-01-01

    Image of the first beam spot on the last BTV screen traversed by the beam during the TI 2 test.At 12:03:47 on 28 October a beam passed down the 2.7 km of the new SPS-to-LHC transfer line TI 2 at the first attempt, to within some 50 m of the LHC tunnel. After initial tuning, a range of measurements was carried out with a low intensity proton beam and preliminary analyses look good. After the test, no increase in radiation levels was found in either the LHC or ALICE, and the zones were rapidly opened again for access. As from next year TI 2 will regularly transport a beam from the SPS to the LHC injection point of Ring 1, near Point 2 (ALICE). The TI 8 transfer line, which will bring particles from the SPS to the injection point in Ring 2, near Point 8 (LHCb), was commissioned successfully with low intensity beam in 2004. The two LHC injection lines have a combined length of 5.6 km and comprise some seven hundred warm magnets. While a...

  14. On-line Observation Of Electron Beam Bunches In The Large Storage Ring Of Kurchatov Srs

    CERN Document Server

    Ioudin, L I; Krylov, Y V; Rezvov, V A; Stirin, A I; Valentinov, A G; Yupinov, Y L

    2004-01-01

    A complex of instrumentation for visual quantitative estimation of electron beam bunches in the big storage ring of Kurchatov Synchrotron Radiation Centre (KSRC) is tested. The bunches pass through a cylindrical electrostatic sensor whose signal is recorded by a wide-band oscillograph. The TV camera reads the optical image of the signal from the oscillograph screen. The TV signal numbering board inputs the video image to the computer memory. The monitor displays the beam bunch structure. A special program provides on-line visualisation of bunch behaviour on the beam orbit. The images of beam structure and a series of images showing the beam behaviour in the regimes of accumulation, acceleration and in the stationary regime a full power are numbered and stored.

  15. Lessons from shielding retrofits at the LAMPF/LANSCE/PSR accelerator, beam lines and target facilities

    International Nuclear Information System (INIS)

    Macek, R.J.

    1994-01-01

    The experience in the past 7 years to improve the shielding and radiation control systems at the Los Alamos Meson Physics Facility (LAMPF) and the Manuel Lujan Jr. Neutron Scattering Center (LANSCE) provides important lessons for the design of radiation control systems at future, high beam power proton accelerator facilities. Major issues confronted and insight gained in developing shielding criteria and in the use of radiation interlocks are discussed. For accelerators and beam lines requiring hands-on-maintenance, our experience suggests that shielding criteria based on accident scenarios will be more demanding than criteria based on routinely encountered beam losses. Specification and analysis of the appropriate design basis accident become all important. Mitigation by active protection systems of the consequences of potential, but severe, prompt radiation accidents has been advocated as an alternate choice to shielding retrofits for risk management at both facilities. Acceptance of active protection systems has proven elusive primarily because of the difficulty in providing convincing proof that failure of active systems (to mitigate the accident) is incredible. Results from extensive shielding assessment studies are presented including data from experimental beam spill tests, comparisons with model estimates, and evidence bearing on the limitations of line-of-sight attenuation models in complex geometries. The scope and significant characteristics of major shielding retrofit projects at the LAMPF site are illustrated by the project to improve the shielding beneath a road over a multiuse, high-intensity beam line (Line D)

  16. Simulation and measurement of the electrostatic beam kicker in the low-energy undulator test line

    International Nuclear Information System (INIS)

    Waldschmidt, G. J.

    1998-01-01

    An electrostatic kicker has been constructed for use in the Low-Energy Undulator Test Line (LEUTL) at the Advanced Photon Source (APS). The function of the kicker is to limit the amount of beam current to be accelerated by the APS linac. Two electrodes within the kicker create an electric field that adjusts the trajectory of the beam. This paper will explore the static fields that are set up between the offset electrode plates and determine the reaction of the beam to this field. The kicker was numerically simulated using the electromagnetic solver package MAFIA [1

  17. MedAustron - Ion-Beam Therapy and Research Center

    International Nuclear Information System (INIS)

    Schreiner, Thomas; Seemann, Rolf

    2015-01-01

    MedAustron is a synchrotron-based light-ion beam therapy center for cancer treatment as well as for clinical and non-clinical research, currently in the commissioning phase in Wiener Neustadt, Austria. Recently, the first proton beam was transported successfully to one of the four irradiation rooms. Whilst the choice of basic machine parameters was driven by medical requirements, i.e. 60 MeV protons and 120 MeV/A to 400 MeV/A carbon ions, the accelerator complex design was also optimized to offer flexibility for research operation. The potential of the synchrotron is being exploited to increase the maximum proton energy far beyond the medical needs to up to 800 MeV, for experimental physics applications, mainly in the areas of proton scattering and detector research. The accelerator layout allows for the installation of up to four ion source-spectrometer units, to provide various ion types besides the clinical used protons and carbon ions. Besides experimental physics, the two main non-clinical research disciplines are medical radiation physics and radiation biology. To decouple research and medical operation, a dedicated irradiation room for non-clinical research was included providing the installation of different experiments. In addition, several labs have been equipped with appropriate devices for preparing and analyzing radio-biological samples. This presentation gives a status overview over the whole project and highlights the non-clinical research opportunities at MedAustron. (Author)

  18. Conceptual design report for the UNI-CAT beam line proposal

    International Nuclear Information System (INIS)

    Budai, J.D.; Ice, G.E.; Sparks, C.J.; Zschack, P.; Chen, H.; Chiang, T.C.; Nelson, M.C.; Salamon, M.B.; Simmons, R.O.; Robota, H.

    1992-08-01

    The overall thrusts of UNI-CAT (University-National Laboratory- Industry Collaborative Access Team) are research at the cutting edge of physics, chemistry, biology, materials science, chemical engineering, polymer science, and geology; and education of a new generation of scientists in the use of synchrotron radiation to probe the structure, chemistry, and dynamic behavior of materials. The UNI-CAT proposal is to develop an APS sector that includes a bending magnet beam line and an insertion device beam line. The APS type-A undulator is the preferred choice for the insertion device. 8 figs, 6 refs

  19. New developments of 11C post-accelerated beams for hadron therapy and imaging

    Science.gov (United States)

    Augusto, R. S.; Mendonca, T. M.; Wenander, F.; Penescu, L.; Orecchia, R.; Parodi, K.; Ferrari, A.; Stora, T.

    2016-06-01

    Hadron therapy was first proposed in 1946 and is by now widespread throughout the world, as witnessed with the design and construction of the CNAO, HIT, PROSCAN and MedAustron treatment centres, among others. The clinical interest in hadron therapy lies in the fact that it delivers precision treatment of tumours, exploiting the characteristic shape (the Bragg peak) of the energy deposition in the tissues for charged hadrons. In particular, carbon ion therapy is found to be biologically more effective, with respect to protons, on certain types of tumours. Following an approach tested at NIRS in Japan [1], carbon ion therapy treatments based on 12C could be combined or fully replaced with 11C PET radioactive ions post-accelerated to the same energy. This approach allows providing a beam for treatment and, at the same time, to collect information on the 3D distributions of the implanted ions by PET imaging. The production of 11C ion beams can be performed using two methods. A first one is based on the production using compact PET cyclotrons with 10-20 MeV protons via 14N(p,α)11C reactions following an approach developed at the Lawrence Berkeley National Laboratory [2]. A second route exploits spallation reactions 19F(p,X)11C and 23Na(p,X)11C on a molten fluoride salt target using the ISOL (isotope separation on-line) technique [3]. This approach can be seriously envisaged at CERN-ISOLDE following recent progresses made on 11C+ production [4] and proven post-acceleration of pure 10C3/6+ beams in the REX-ISOLDE linac [5]. Part of the required components is operational in radioactive ion beam facilities or commercial medical PET cyclotrons. The driver could be a 70 MeV, 1.2 mA proton commercial cyclotron, which would lead to 8.1 × 10711C6+ per spill. This intensity is appropriate using 11C ions alone for both imaging and treatment. Here we report on the ongoing feasibility studies of such approach, using the Monte Carlo particle transport code FLUKA [6,7] to simulate

  20. New developments of {sup 11}C post-accelerated beams for hadron therapy and imaging

    Energy Technology Data Exchange (ETDEWEB)

    Augusto, R.S., E-mail: r.s.augusto@cern.ch [European Organization for Nuclear Research – CERN, 1211 Geneva 23 (Switzerland); Ludwig Maximilians – University of Munich, Munich (Germany); Mendonca, T.M.; Wenander, F. [European Organization for Nuclear Research – CERN, 1211 Geneva 23 (Switzerland); Penescu, L. [MedAustron GmbH, Wiener Neustadt (Austria); Orecchia, R. [CNAO – Centro Nazionale di Adroterapia Oncologica per il trattamento dei tumori, Pavia (Italy); Parodi, K. [Ludwig Maximilians – University of Munich, Munich (Germany); Ferrari, A.; Stora, T. [European Organization for Nuclear Research – CERN, 1211 Geneva 23 (Switzerland)

    2016-06-01

    Hadron therapy was first proposed in 1946 and is by now widespread throughout the world, as witnessed with the design and construction of the CNAO, HIT, PROSCAN and MedAustron treatment centres, among others. The clinical interest in hadron therapy lies in the fact that it delivers precision treatment of tumours, exploiting the characteristic shape (the Bragg peak) of the energy deposition in the tissues for charged hadrons. In particular, carbon ion therapy is found to be biologically more effective, with respect to protons, on certain types of tumours. Following an approach tested at NIRS in Japan [1], carbon ion therapy treatments based on {sup 12}C could be combined or fully replaced with {sup 11}C PET radioactive ions post-accelerated to the same energy. This approach allows providing a beam for treatment and, at the same time, to collect information on the 3D distributions of the implanted ions by PET imaging. The production of {sup 11}C ion beams can be performed using two methods. A first one is based on the production using compact PET cyclotrons with 10–20 MeV protons via {sup 14}N(p,α){sup 11}C reactions following an approach developed at the Lawrence Berkeley National Laboratory [2]. A second route exploits spallation reactions {sup 19}F(p,X){sup 11}C and {sup 23}Na(p,X){sup 11}C on a molten fluoride salt target using the ISOL (isotope separation on-line) technique [3]. This approach can be seriously envisaged at CERN-ISOLDE following recent progresses made on {sup 11}C{sup +} production [4] and proven post-acceleration of pure {sup 10}C{sup 3/6+} beams in the REX-ISOLDE linac [5]. Part of the required components is operational in radioactive ion beam facilities or commercial medical PET cyclotrons. The driver could be a 70 MeV, 1.2 mA proton commercial cyclotron, which would lead to 8.1 × 10{sup 711}C{sup 6+} per spill. This intensity is appropriate using {sup 11}C ions alone for both imaging and treatment. Here we report on the ongoing feasibility

  1. 21 CFR 892.5710 - Radiation therapy beam-shaping block.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Radiation therapy beam-shaping block. 892.5710 Section 892.5710 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... block. (a) Identification. A radiation therapy beam-shaping block is a device made of a highly...

  2. Optimization and verification of image reconstruction for a Compton camera towards application as an on-line monitor for particle therapy

    Science.gov (United States)

    Taya, T.; Kataoka, J.; Kishimoto, A.; Tagawa, L.; Mochizuki, S.; Toshito, T.; Kimura, M.; Nagao, Y.; Kurita, K.; Yamaguchi, M.; Kawachi, N.

    2017-07-01

    Particle therapy is an advanced cancer therapy that uses a feature known as the Bragg peak, in which particle beams suddenly lose their energy near the end of their range. The Bragg peak enables particle beams to damage tumors effectively. To achieve precise therapy, the demand for accurate and quantitative imaging of the beam irradiation region or dosage during therapy has increased. The most common method of particle range verification is imaging of annihilation gamma rays by positron emission tomography. Not only 511-keV gamma rays but also prompt gamma rays are generated during therapy; therefore, the Compton camera is expected to be used as an on-line monitor for particle therapy, as it can image these gamma rays in real time. Proton therapy, one of the most common particle therapies, uses a proton beam of approximately 200 MeV, which has a range of ~ 25 cm in water. As gamma rays are emitted along the path of the proton beam, quantitative evaluation of the reconstructed images of diffuse sources becomes crucial, but it is far from being fully developed for Compton camera imaging at present. In this study, we first quantitatively evaluated reconstructed Compton camera images of uniformly distributed diffuse sources, and then confirmed that our Compton camera obtained 3 %(1 σ) and 5 %(1 σ) uniformity for line and plane sources, respectively. Based on this quantitative study, we demonstrated on-line gamma imaging during proton irradiation. Through these studies, we show that the Compton camera is suitable for future use as an on-line monitor for particle therapy.

  3. Definitive proton beam radiation therapy for inoperable gastric cancer

    International Nuclear Information System (INIS)

    Shibuya, Susumu; Takase, Yasuhiro; Aoyagi, Hiroyuki; Orii, Kazuo; Sharma, N.; Iwasaki, Yoji; Tsujii, Hirohiko; Tsujii, Hiroshi.

    1991-01-01

    Proton beam radiation therapy using 250 MeV protons was carried out on two patients with early gastric cancer (T1, N0, M0). One patient was an 85-year-old man with early gastric cancer of type IIa + IIc. The other one was a 70-year-old man with early gastric cancer of type IIc. In both cases histological examination of biopsy specimens showed differential adenocarcinoma; distant metastasis was not found by other examinations. Both patients were considered inoperable due to their poor cardiac and/or respiratory functions. Therefore, it was decided to treat them by definitive proton irradiation, delivering total doses of 86 Gy and 83 Gy, respectively. In both patients, skin erythema that did not require any special treatment was found in the irradiation field. Hematobiological examinations did not show any abnormality. Although endoscopic examination at two years after irradiation in the former case and at seven months in the latter case showed persistent gastric ulcer at the site of the cancerous lesions, cancer cells were not found histologically. Therefore, we concluded that proton irradiation therapy was useful for inoperable early gastric cancers. (author)

  4. Present Status And First Results of the Final Focus Beam Line at the KEK Accelerator Test Facility

    International Nuclear Information System (INIS)

    2010-01-01

    ATF2 is a final-focus test beam line which aims to focus the low emittance beam from the ATF damping ring to a vertical size of about 37 nm and to demonstrate nanometer level beam stability. Several advanced beam diagnostics and feedback tools are used. In December 2008, construction and installation were completed and beam commissioning started, supported by an international team of Asian, European, and U.S. scientists. The present status and first results are described.

  5. Present status and first results of the final focus beam line at the KEK Accelerator Test Facility

    CERN Document Server

    Bambade, P; Amann, J; Angal-Kalinin, D; Apsimon, R; Araki, S; Aryshev, A; Bai, S; Bellomo, P; Bett, D; Blair, G; Bolzon, B; Boogert, S; Boorman, G; Burrows, P N; Christian, G; Coe, P; Constance, B; Delahaye, J P; Deacon, L; Elsen, E; Faus-Golfe, A; Fukuda, M; Gao, J; Geffroy, N; Gianfelice-Wendt, E; Guler, H; Hayano, H; Heo, A Y; Honda, Y; Huang, J Y; Hwang, W H; Iwashita, Y; Jeremie, A; Jones, J; Kamiya, Y; Karataev, P; Kim, E S; Kim, H S; Kim, S H; Komamiya, S; Kubo, K; Kume, T; Kuroda, S; Lam, B; Lyapin, A; Masuzawa, M; McCormick, D; Molloy, S; Naito, T; Nakamura, T; Nelson, J; Okamoto, D; Okugi, T; Oroku, M; Park, Y J; Parker, B; Paterson, E; Perry, C; Pivi, M; Raubenheimer, T; Renier, Y; Resta-Lopez, J; Rimbault, C; Ross, M; Sanuki, T; Scarfe, A; Schulte, D; Seryi, A; Spencer, C; Suehara, T; Sugahara, R; Swinson, C; Takahashi, T; Tauchi, T; Terunuma, N; Tomas, R; Urakawa, J; Urner, D; Verderi, M; Wang, M H; Warden, M; Wendt, M; White, G; Wittmer, W; Wolski, A; Woodley, M; Yamaguchi, Y; Yamanaka, T; Yan, Y; Yoda, H; Yokoya, K; Zhou, F; Zimmermann, F; 10.1103/PhysRevSTAB.13.042801

    2010-01-01

    ATF2 is a final-focus test beam line which aims to focus the low emittance beam from the ATF damping ring to a vertical size of about 37 nm and to demonstrate nanometer level beam stability. Several advanced beam diagnostics and feedback tools are used. In December 2008, construction and installation were completed and beam commissioning started, supported by an international team of Asian, European, and U.S. scientists. The present status and first results are described.

  6. Intraoperative electron beam radiation therapy (IOEBRT) for carcinoma of the exocrine pancreas

    International Nuclear Information System (INIS)

    Dobelbower, R.R. Jr.; Konski, A.A.; Merrick, H.W. III; Bronn, D.G.; Schifeling, D.; Kamen, C.

    1991-01-01

    The abdominal cavities of 50 patients were explored in a specially constructed intraoperative radiotherapy operating amphitheater at the Medical College of Ohio. Twenty-six patients were treated with intraoperative and postoperative precision high dose external beam therapy, 12 with intraoperative irradiation but no external beam therapy, and 12 with palliative surgery alone. All but two patients completed the postoperative external beam radiation therapy as initially prescribed. The median survival time for patients treated with palliative surgery alone was 4 months, and that for patients treated with intraoperative radiotherapy without external beam therapy was 3.5 months. Patients undergoing intraoperative irradiation and external beam radiation therapy had a median survival time of 10.5 months. Four patients died within 30 days of surgery and two patients died of gastrointestinal hemorrhage 5 months posttreatment

  7. Design of the low energy beam transport line between CARIBU and the EBIS charge breeder

    Energy Technology Data Exchange (ETDEWEB)

    Perry, A., E-mail: aperry4@hawk.iit.edu [Argonne National Laboratory, Argonne, IL 60439, USA and Illinois Institute of Technology, Chicago, IL 60616 (United States); Ostroumov, P. N.; Barcikowski, A.; Dickerson, C.; Kondrashev, S. A.; Mustapha, B.; Savard, G. [Argonne National Laboratory, Argonne, IL 60439 (United States)

    2015-01-09

    An Electron Beam Ion Source Charge Breeder (EBIS-CB) has been developed to breed radioactive beams from the CAlifornium Rare Isotope Breeder Upgrade (CARIBU) facility at ATLAS. The EBIS-CB will replace the existing ECR charge breeder to increase the intensity and improve the purity of reaccelerated radioactive ion beams. The EBIS-CB is in the final stage of off-line commissioning. Currently, we are developing a low energy beam transport (LEBT) system to transfer CARIBU beams to the EBIS-CB. As was originally planned, an RFQ cooler-buncher will precede the EBIS-CB. Recently, it was decided to include a multi-reflection time-of-flight (MR-TOF) mass-spectrometer following the RFQ. MR-TOF is a relatively new technology used to purify beams with a mass-resolving power up to 3×10{sup 5} as was demonstrated in experiments at CERN/ISOLDE. Very high purity singly-charged radioactive ion beams will be injected into the EBIS for charge breeding and due to its inherent properties, the EBIS-CB will maintain the purity of the charge bred beams. Possible contamination of residual gas ions will be greatly suppressed by achieving ultra-high vacuum in the EBIS trap. This paper will present and discuss the design of the LEBT and the overall integration of the EBIS-CB into ATLAS.

  8. Biological basis of heavy ion beams for cancer therapy

    International Nuclear Information System (INIS)

    Sakamoto, Kiyohiko

    1985-01-01

    Fast neutron therapy has started firstly and proton therapy has commenced secondly, fast neutron shows better biological effects compared to conventional radiations but its dose distribution is not good, and proton demonstrates excellent dose distribution but its biological effects are almost the same as that of conventional radiations. On the other hand, negative pi-mesons and heavy ions indicate high radiobiological effect and excellent dose distribution, therefore these particle radiations is considered to be more attractive for radiotherapeutic radiations to enhance cure rate of cancers. The biological strong points of these particles are as follows : 1) cells exposed to these particle radiations shows less recovery after irradiation compared to conventional radiations, 2) these radiations show high biological effects (high value of relative biological effectiveness = RBE) when the same dose is given, 3) big effects on hypoxic cells which exsist in tumor, i.e. the value of oxygen enhancement ratio (OER) is low, 4) the differences in radiosensitivity by stages of cell cycle are not so great (data was not shown in present paper), 5) biological effects at prepeak plateau region in depth dose curve formed by these particle radiations is less than that at peak region (therefore, if beam is modulated to cover tumor at spraed out broad peak, tumors is given more biological effect compared to normal tissues which is to be exposed to radiations at prepaeak region). Clinical trial using heavy ions are being performed at Lawrence Berkeley Laboratory which is only one facility to be able to try clinical trial. The results of clinical trials at Lawrence Berkeley Laboratory suggest to be very prospective to enhance tumor cure rate, however it is too early to estimate the effect of heavy ion therapy. (J.P.N.)

  9. Vinorelbine as first-line or second-line therapy for advanced breast cancer

    DEFF Research Database (Denmark)

    Langkjer, Sven T; Ejlertsen, Bent; Mouridsen, Henning

    2008-01-01

    INTRODUCTION: This study was conducted to establish the maximum tolerated dose (MTD) of intravenous vinorelbine and on the determined dose to assess efficacy and safety in patients with metastatic breast cancer previously treated with epirubicin. PATIENTS AND METHODS: Patients had histologically...... proven breast cancer and had received a prior epirubicin based regimen either adjuvant or as first line therapy for advanced disease. Vinorelbine was administered intravenously day 1 and 8 in a 3 weeks' schedule. Subsequently 48 additional patients were treated at one dose-level below MTD. RESULTS: Fifty...

  10. Upgrades to the SPS-to-LHC Transfer Line Beam Stoppers for the LHC High-Luminosity Era

    CERN Document Server

    Kain, Verena; Fraser, Matthew; Goddard, Brennan; Meddahi, Malika; Perillo Marcone, Antonio; Steele, Genevieve; Velotti, Francesco

    2016-01-01

    Each of the 3 km long transfer lines between the SPS and the LHC is equipped with two beam stoppers (TEDs), one at the beginning of the line and one close to the LHC injection point, which need to absorb the full transferred beam. The beam stoppers are used for setting up the SPS extractions and transfer lines with beam without having to inject into the LHC. Energy deposition and thermo-mechanical simulations have, however, shown that the TEDs will not be robust enough to safely absorb the high intensity beams foreseen for the high-luminosity LHC era. This paper will summarize the simulation results and limitations for upgrading the beam stoppers. An outline of the hardware upgrade strategy for the TEDs together with modifications to the SPS extraction interlock system to enforce intensity limitations for beam on the beam stoppers will be given.

  11. Optical design of beam lines at the KEK-PS new experimental hall

    International Nuclear Information System (INIS)

    Tanaka, K.H.; Ieiri, M.; Noumi, H.; Minakawa, M.; Yamanoi, Y.; Kato, Y.; Ishii, H.; Suzuki, Y.; Takasaki, M.

    1995-01-01

    A new counter experimental hall [K.H. Tanaka et al., IEEE Trans. Magn. 28 (1992) 697] was designed and constructed at the KEK 12-GeV Proton Synchrotron (KEK-PS). The extracted proton beam from the KEK-PS is introduced to the new hall through the newly-prepared primary beam line, EP1, and hits two production targets in cascade. The upstream target provides secondary particles to the low momentum (0.4-0.6 GeV/c) separated beam line, K5, and the downstream target is connected to the medium momentum (0.6-2.0 GeV/c) separated beam line, K6. Several new ideas were employed in the beam optical designs of EP1, K5 and K6 in order to increase the number and the purity of the short-lived secondary particles, such as kaons and pions, under the limited energy and intensity of the primary protons provided by the KEK-PS. These new ideas are described in this paper as well as the first commissioning results. (orig.)

  12. High beam current shut-off systems in the APS linac and low energy transfer line

    International Nuclear Information System (INIS)

    Wang, X.; Knott, M.; Lumpkin, A.

    1994-01-01

    Two independent high beam current shut-off current monitoring systems (BESOCM) have been installed in the APS linac and the low energy transport line to provide personnel safety protection in the event of acceleration of excessive beam currents. Beam current is monitored by a fast current transformer (FCT) and fully redundant supervisory circuits connected to the Access Control Interlock System (ACIS) for beam intensity related shutdowns of the linac. One FCT is located at the end of the positron linac and the other in the low energy transport line, which directs beam to the positron accumulator ring (PAR). To ensure a high degree of reliability, both systems employ a continuous self-checking function, which injects a test pulse to a single-turn test winding after each ''real'' beam pulse to verify that the system is fully functional. The system is designed to be fail-safe for all possible system faults, such as loss of power, open or shorted signal or test cables, loss of external trigger, malfunction of gated integrator, etc. The system has been successfully commissioned and is now a reliable part of the total ACIS

  13. Sub-second pencil beam dose calculation on GPU for adaptive proton therapy.

    Science.gov (United States)

    da Silva, Joakim; Ansorge, Richard; Jena, Rajesh

    2015-06-21

    Although proton therapy delivered using scanned pencil beams has the potential to produce better dose conformity than conventional radiotherapy, the created dose distributions are more sensitive to anatomical changes and patient motion. Therefore, the introduction of adaptive treatment techniques where the dose can be monitored as it is being delivered is highly desirable. We present a GPU-based dose calculation engine relying on the widely used pencil beam algorithm, developed for on-line dose calculation. The calculation engine was implemented from scratch, with each step of the algorithm parallelized and adapted to run efficiently on the GPU architecture. To ensure fast calculation, it employs several application-specific modifications and simplifications, and a fast scatter-based implementation of the computationally expensive kernel superposition step. The calculation time for a skull base treatment plan using two beam directions was 0.22 s on an Nvidia Tesla K40 GPU, whereas a test case of a cubic target in water from the literature took 0.14 s to calculate. The accuracy of the patient dose distributions was assessed by calculating the γ-index with respect to a gold standard Monte Carlo simulation. The passing rates were 99.2% and 96.7%, respectively, for the 3%/3 mm and 2%/2 mm criteria, matching those produced by a clinical treatment planning system.

  14. The Fluka Linebuilder and Element Database: Tools for Building Complex Models of Accelerators Beam Lines

    CERN Document Server

    Mereghetti, A; Cerutti, F; Versaci, R; Vlachoudis, V

    2012-01-01

    Extended FLUKA models of accelerator beam lines can be extremely complex: heavy to manipulate, poorly versatile and prone to mismatched positioning. We developed a framework capable of creating the FLUKA model of an arbitrary portion of a given accelerator, starting from the optics configuration and a few other information provided by the user. The framework includes a builder (LineBuilder), an element database and a series of configuration and analysis scripts. The LineBuilder is a Python program aimed at dynamically assembling complex FLUKA models of accelerator beam lines: positions, magnetic fields and scorings are automatically set up, and geometry details such as apertures of collimators, tilting and misalignment of elements, beam pipes and tunnel geometries can be entered at user’s will. The element database (FEDB) is a collection of detailed FLUKA geometry models of machine elements. This framework has been widely used for recent LHC and SPS beam-machine interaction studies at CERN, and led to a dra...

  15. In situ baking method for degassing of a kicker magnet in accelerator beam line

    International Nuclear Information System (INIS)

    Kamiya, Junichiro; Ogiwara, Norio; Yanagibashi, Toru; Kinsho, Michikazu; Yasuda, Yuichi

    2016-01-01

    In this study, the authors propose a new in situ degassing method by which only kicker magnets in the accelerator beam line are baked out without raising the temperature of the vacuum chamber to prevent unwanted thermal expansion of the chamber. By simply installing the heater and thermal radiation shield plates between the kicker magnet and the chamber wall, most of the heat flux from the heater directs toward the kicker magnet. The result of the verification test showed that each part of the kicker magnet was heated to above the target temperature with a small rise in the vacuum chamber temperature. A graphite heater was selected in this application to bake-out the kicker magnet in the beam line to ensure reliability and easy maintainability of the heater. The vacuum characteristics of graphite were suitable for heater operation in the beam line. A preliminary heat-up test conducted in the accelerator beam line also showed that each part of the kicker magnet was successfully heated and that thermal expansion of the chamber was negligibly small

  16. In situ baking method for degassing of a kicker magnet in accelerator beam line

    Energy Technology Data Exchange (ETDEWEB)

    Kamiya, Junichiro, E-mail: kamiya.junichiro@jaea.go.jp; Ogiwara, Norio; Yanagibashi, Toru; Kinsho, Michikazu [Japan Atomic Energy Agency, J-PARC Center, Ooaza Shirakata 2-4, Tokai, Naka, Ibaraki 319-1195 (Japan); Yasuda, Yuichi [SAKAGUCHI E.H VOC CORP., Sakura Dai-san Kogyodanchi 1-8-6, Osaku, Sakura, Chiba 285-0802 (Japan)

    2016-03-15

    In this study, the authors propose a new in situ degassing method by which only kicker magnets in the accelerator beam line are baked out without raising the temperature of the vacuum chamber to prevent unwanted thermal expansion of the chamber. By simply installing the heater and thermal radiation shield plates between the kicker magnet and the chamber wall, most of the heat flux from the heater directs toward the kicker magnet. The result of the verification test showed that each part of the kicker magnet was heated to above the target temperature with a small rise in the vacuum chamber temperature. A graphite heater was selected in this application to bake-out the kicker magnet in the beam line to ensure reliability and easy maintainability of the heater. The vacuum characteristics of graphite were suitable for heater operation in the beam line. A preliminary heat-up test conducted in the accelerator beam line also showed that each part of the kicker magnet was successfully heated and that thermal expansion of the chamber was negligibly small.

  17. A very sensitive nonintercepting beam average velocity monitoring system for the TRIUMF 300-keV injection line

    International Nuclear Information System (INIS)

    Yin, Y.; Laxdal, R.E.; Zelenski, A.; Ostroumov, P.

    1997-01-01

    A nonintercepting beam velocity monitoring system has been installed in the 300-keV injection line of the TRIUMF cyclotron to reproduce the injection energy for beam from different ion sources and to monitor any beam energy fluctuations. By using a programmable beam signal leveling method the system can work with a beam current dynamic range of 50 dB. Using synchronous detection, the system can detect 0.5 eV peak-to-peak energy modulation of the beam, sensitivity is 1.7x10 -6 . The paper will describe the principle and beam measurement results. copyright 1997 American Institute of Physics

  18. Beam-line considerations for experiments with highly-charged ions

    International Nuclear Information System (INIS)

    Johnson, B.M.

    1990-01-01

    The APS offers exciting possibilities for a bright future in x-ray research. For example, measurements on the inner-shell photoionization of ions will be feasible using stored ions in ions traps or ion beams from an electron-cyclotron-resonance ion source, or perhaps even a heavy-ion storage ring. Such experiments with ionic targets are the focus for the discussion given here on the optimization of photon flux on a generic beamline at the APS. The performance of beam lines X26C, X26A, and X17 on the x-ray ring of the National Synchrotron Light Source will be discussed as specific examples of beam-line design considerations

  19. Beam-line considerations for experiments with highly-charged ions

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, B.M.

    1990-01-01

    The APS offers exciting possibilities for a bright future in x-ray research. For example, measurements on the inner-shell photoionization of ions will be feasible using stored ions in ions traps or ion beams from an electron-cyclotron-resonance ion source, or perhaps even a heavy-ion storage ring. Such experiments with ionic targets are the focus for the discussion given here on the optimization of photon flux on a generic beamline at the APS. The performance of beam lines X26C, X26A, and X17 on the x-ray ring of the National Synchrotron Light Source will be discussed as specific examples of beam-line design considerations.

  20. New development of hadron physics at new laser electron beam line (LEP2) of SPring-8

    International Nuclear Information System (INIS)

    Muramatsu, Norihito; Niiyama, Masayuki; Yosoi, Masaru

    2015-01-01

    This paper introduces the outline of LEPS2 beam line and two types of large detectors (electromagnetic calorimeter BGOegg and solenoid spectrometer), LEPS2/BGOegg experiment, and the target physics using LEPS2 solenoid spectrometer. In LEPS2 beam line, experiments are performed with the improvement of beam intensity by nearly one digit due to the simultaneous incidence of multiple lasers of high output, as well as with the installation of a large solid angle high-resolution detector. In LEPS2/BGOegg experiment, direct observation with a large solid angle of mesons such as π 0 , η, η', and ω has become possible, which has given expectation for new physics. As one of the physics at the core of BGOegg experiments, there is the systematic examination of interaction between η' and nucleus/nucleon. In the physics using a solenoid spectrometer, the first target is the measurement of penta-quark particle Θ + . (A.O.)

  1. Physics design of heavy-ion irradiation beam line on HI-13 tandem accelerator

    International Nuclear Information System (INIS)

    Zhu Fei; Peng Zhaohua; Hu Yueming; Jiao Xuesheng; Chen Dongfeng; Cao Yali

    2014-01-01

    Background: Heavy-ion microporous membrane is a new kind of filter material, which has prosperous application in the fields of medical and biological agents, electronic, food, environmental science, materials science, etc. Purpose: Polyester membranes were irradiated with 32 S produced by HI-13 tandem accelerator to develop a microporous membrane at CIAE, and the irradiation uniformity is determined by the beam distribution, also the microporous uniformity is required higher than 90%. Methods: An octupole magnet was used to correct the beam distribution from Gauss to uniform. Meanwhile, main parameters of beam line were given, and the alignment tolerances for optical elements were also analyzed. Results: Alignment tolerance of the optical elements could cause great influence on the beam center deviation in the process of correction, which would destroy the irradiation uniformity. Steering magnet was applied to meet with the design requirements. Conclusion: This study provides a practical and feasible way for industrial production of heavy-ion microporous membrane. (authors)

  2. Characterization of electron beams generated in a high-voltage pulse-line-driven pseudospark discharge

    International Nuclear Information System (INIS)

    Ramaswamy, K.; Destler, W.W.; Segalov, Z.; Rodgers, J.

    1994-01-01

    Emittance and energy measurements have been performed on a high-brightness electron beam (>10 10 A/m 2 rad 2 ) with diameter in the range 1--3 mm and energy in the range 150--170 keV. This electron beam is generated by the mating of a hollow-cathode discharge device operating in the pseudospark regime to the output of a high-power pulse line accelerator. The measured effective emittance lies in the range between 30 and 90 mm mrad and increases with axial distance. Electron energy measurements indicate that the high-energy electrons are generated during the first 20--30 ns of the discharge. Both the emittance and energy experiments were performed at two different ambient argon gas pressures (92 and 152 mtorr). Beam expansion as a function of axial position has also been studied and a lower bound on the beam brightness has been obtained

  3. Mechanical Design of a Heavy Ion Beam Dump for the RIA Fragmentation Line

    Energy Technology Data Exchange (ETDEWEB)

    Stein, W; Ahle, L E; Conner, D L

    2005-04-28

    The RIA fragmentation line requires a beam stop for the primary beam downstream of the first dipole magnet. The beam may consist of U, Ca, Sn, Kr, or O ions. with a variety of power densities. The configuration with highest power density is for the U beam, with a spot size of 3 cm x 3 cm and a total power of up to 300 kW. The mechanical design of the dump that meets these criteria consists of a 70 cm diameter aluminum wheel with water coolant channels. A hollow drive shaft supplies the coolant water and connects the wheel to an electrical motor located in an adjacent air space. The beam strikes the wheel along the outer perimeter and passes through a thin window of aluminum where 15% of its power is absorbed and the remainder of the beam is absorbed in flowing water behind the window. Rotation of the wheel at 400 RPM results in maximum aluminum temperatures below 100 C and acceptably low thermal stresses of 3 ksi. Rotating the wheel also results in low radiation damage levels by spreading the damage out over the whole perimeter of the wheel. For some of the other beams, a stationary dump consisting of a thin aluminum window with water acting as a coolant and absorber appears to be feasible.

  4. Magnetically insulated transmission line used for relativistic electron beam injection into SPAC-VI

    International Nuclear Information System (INIS)

    Tsuzuki, Tetsuya; Narihara, Kazumichi; Tomita, Yukihiro; Mohri, Akihiro.

    1980-10-01

    For the purpose to inject the electron beam with energy of about 1.5 MeV and current of about 100 kA into the SPAC-6 (torus device), a magnetically insulated transmission line was designed and constructed. The motion of electrons in the line was theoretically analyzed. The requirements for the design of the transmission line were as follows-: (a) condition of magnetic insulation, (b) suppression against reverse gas flow from the beam source to the torus, (c) care to minimize the influence of strong torus magnetic field, (d) reduction of inductance and (e) safety engineering measures, e.g., separation valve in the MITL between the beam source and the SPAC-6. The transmission line of 2.4 m long was designed and constructed. The wave forms of electric potential and current were measured. The transmission efficiency of current along the axis and the efficiency as a function of current at the end of the line were also measured. The reason of the loss of current is discussed. (J.P.N.)

  5. Beam line 4: A dedicated surface science facility at Daresbury Laboratory

    International Nuclear Information System (INIS)

    Dhanak, V.R.; Robinson, A.W.; van der Laan, G.; Thornton, G.

    1992-01-01

    We describe a beam line currently under construction at the Daresbury Laboratory which forms part of a surface science research facility for the Interdisciplinary Research Centre in Surface Science. The beam line has three branches, two of which are described here. The first branch covers the high-energy range 640 eV≤hν≤10 keV, being equipped with a double-crystal monochromator and a novel multicoated premirror system. The second branch line is optimized for the energy range 15≤hν≤250 eV, using cylindrical focusing mirrors, a spherical diffraction grating and an ellipsoidal refocusing mirror to achieve high resolution with a small spot size

  6. Powerloads on the front end components and the duct of the heating and diagnostic neutral beam lines at ITER

    Energy Technology Data Exchange (ETDEWEB)

    Singh, M. J.; Boilson, D.; Hemsworth, R. S.; Geli, F.; Graceffa, J.; Urbani, M.; Schunke, B.; Chareyre, J. [ITER Organisation, 13607 St. Paul-Lez-Durance Cedex (France); Dlougach, E.; Krylov, A. [RRC Kurchatov institute, 1, Kurchatov Sq, Moscow, 123182 (Russian Federation)

    2015-04-08

    The heating and current drive beam lines (HNB) at ITER are expected to deliver ∼16.7 MW power per beam line for H beams at 870 keV and D beams at 1 MeV during the H-He and the DD/DT phases of ITER operation respectively. On the other hand the diagnostic neutral beam (DNB) line shall deliver ∼2 MW power for H beams at 100 keV during both the phases. The path lengths over which the beams from the HNB and DNB beam lines need to be transported are 25.6 m and 20.7 m respectively. The transport of the beams over these path lengths results in beam losses, mainly by the direct interception of the beam with the beam line components and reionisation. The lost power is deposited on the surfaces of the various components of the beam line. In order to ensure the survival of these components over the operational life time of ITER, it is important to determine to the best possible extent the operational power loads and power densities on the various surfaces which are impacted by the beam in one way or the other during its transport. The main factors contributing to these are the divergence of the beamlets and the halo fraction in the beam, the beam aiming, the horizontal and vertical misalignment of the beam, and the gas profile along the beam path, which determines the re-ionisation loss, and the re-ionisation cross sections. The estimations have been made using a combination of the modified version of the Monte Carlo Gas Flow code (MCGF) and the BTR code. The MCGF is used to determine the gas profile in the beam line and takes into account the active gas feed into the ion source and neutraliser, the HNB-DNB cross over, the gas entering the beamline from the ITER machine, the additional gas atoms generated in the beam line due to impacting ions and the pumping speed of the cryopumps. The BTR code has been used to obtain the power loads and the power densities on the various surfaces of the front end components and the duct modules for different scenarios of ITER

  7. LHCB: A LHCb-VELO module as beam quality monitor for proton therapy beam at the Clatterbridge Centre for Oncology

    CERN Multimedia

    Casse, G; Patel, G D; Smith, N A; Kacperek, A; Marsland, B

    2010-01-01

    The progress in detector technology, driven by the needs of particle tracking and vertexing in the present LHC and its upgrade (sLHC), has led to the design of silicon sensors with low mass, high granularity, high speed and unprecedented radiation hardness. The sensors designed for such a harsh environment can be profitably used for instrumenting the control systems of therapeutic hadron beams. The high granularity and readout clock speed are well suited for monitoring continuous beam currents. The low mass allows reduced interference with the beam whilst monitoring its profile with high precision. The high resolution and sensitivity to minimum ionising particles allows monitoring of the beam spot position by measurement of the halo in real time, without any interference with the beam spot used in therapy.

  8. Early experience of proton beam therapy combined with chemotherapy for locally advanced oropharyngeal cancer

    International Nuclear Information System (INIS)

    Ishikawa, Youjirou; Nakamura, Tatsuya; Takada, Akinori; Takayama, Kanako; Makita, Chiyoko; Suzuki, Motohisa; Azami, Yusuke; Kikuchi, Yasuhiro; Fuwa, Nobukazu

    2013-01-01

    Between 2009 and 2012, 10 patients with advanced oropharyngeal cancer underwent proton therapy combined with chemotherapy. The initial results of this therapy were 8 complete response (CR) and 2 partial response (PR), local recurrence was detected 1 patient. Proton beam therapy combined with chemotherapy is thought to be an effective treatment for locally advanced oropharyngeal cancer. (author)

  9. Preliminary results of the Gas Electron Multiplier (GEM) as real-time beam monitor in hadron therapy

    Energy Technology Data Exchange (ETDEWEB)

    Aza, E., E-mail: eleni.aza@cern.ch [CERN, Geneva 23, 1211 Geneva (Switzerland); AUTH, Department of Physics, 54124 Thessaloniki (Greece); Ciocca, M. [Fondazione CNAO, Strada Campeggi 53, 27100 Pavia (Italy); Murtas, F. [CERN, Geneva 23, 1211 Geneva (Switzerland); LNF-INFN, Via Fermi 40, 00044 Frascati (Italy); Puddu, S. [CERN, Geneva 23, 1211 Geneva (Switzerland); AEC-LHEP, University of Bern, Sidlerstrasse 5, 3012 Bern (Switzerland); Pullia, M. [Fondazione CNAO, Strada Campeggi 53, 27100 Pavia (Italy); Silari, M. [CERN, Geneva 23, 1211 Geneva (Switzerland)

    2017-01-01

    The use of proton and carbon ion beams in cancer therapy (also known as hadron therapy) is progressively growing worldwide due to their improved dose distributions, sparing of healthy tissues and (for carbon ions) increased radiobiological effectiveness especially for radio-resistant tumours. Strict Quality Assurance (QA) protocols need to be followed for guaranteeing the clinical beam specifications. The aim of this study was to assess the performance of a gaseous detector based on the Gas Electron Multiplier (GEM) technology for measuring the beam spot dimensions and the homogeneity of the scanned irradiation field, which are daily QA tasks commonly performed using radiochromic films. Measurements performed at the National Centre for Oncological Hadron Therapy (CNAO) in Pavia (Italy) showed that the detector is able to monitor the 2D beam image on-line with a pad granularity of 2 mm and a response proportional to the number of delivered particles. The dose homogeneity was measured with low deviation from the results obtained with radiochromic films.

  10. 3D printed plastics for beam modulation in proton therapy

    International Nuclear Information System (INIS)

    Lindsay, C; Hoehr, C; Kumlin, J; Schaffer, P; Jirasek, A; Lee, R; Martinez, D M

    2015-01-01

    Two 3D printing methods, fused filament fabrication (FFF) and PolyJet™ (PJ) were investigated for suitability in clinical proton therapy (PT) energy modulation. Measurements of printing precision, printed density and mean stopping power are presented. FFF is found to be accurate to 0.1 mm, to contain a void fraction of 13% due to air pockets and to have a mean stopping power dependent on geometry. PJ was found to print accurate to 0.05 mm, with a material density and mean stopping power consistent with solid poly(methyl methacrylate) (PMMA). Both FFF and PJ were found to print significant, sporadic defects associated with sharp edges on the order of 0.2 mm. Site standard PT modulator wheels were printed using both methods. Measured depth-dose profiles with a 74 MeV beam show poor agreement between PMMA and printed FFF wheels. PJ printed wheel depth-dose agreed with PMMA within 1% of treatment dose except for a distal falloff discrepancy of 0.5 mm. (note)

  11. Proton Beam Therapy Interference With Implanted Cardiac Pacemakers

    International Nuclear Information System (INIS)

    Oshiro, Yoshiko; Sugahara, Shinji; Noma, Mio; Sato, Masato; Sakakibara, Yuzuru; Sakae, Takeji; Hayashi, Yasutaka; Nakayama, Hidetsugu; Tsuboi, Koji; Fukumitsu, Nobuyoshi; Kanemoto, Ayae; Hashimoto, Takayuki; Tokuuye, Koichi

    2008-01-01

    Purpose: To investigate the effect of proton beam therapy (PBT) on implanted cardiac pacemaker function. Methods and Materials: After a phantom study confirmed the safety of PBT in patients with cardiac pacemakers, we treated 8 patients with implanted pacemakers using PBT to a total tumor dose of 33-77 gray equivalents (GyE) in dose fractions of 2.2-6.6 GyE. The combined total number of PBT sessions was 127. Although all pulse generators remained outside the treatment field, 4 patients had pacing leads in the radiation field. All patients were monitored by means of electrocardiogram during treatment, and pacemakers were routinely examined before and after PBT. Results: The phantom study showed no effect of neutron scatter on pacemaker generators. In the study, changes in heart rate occurred three times (2.4%) in 2 patients. However, these patients remained completely asymptomatic throughout the PBT course. Conclusions: PBT can result in pacemaker malfunctions that manifest as changes in pulse rate and pulse patterns. Therefore, patients with cardiac pacemakers should be monitored by means of electrocardiogram during PBT

  12. Rhabdomyosarcoma of the trachea: first reported case treated with proton beam therapy.

    Science.gov (United States)

    Exley, R; Bernstein, J M; Brennan, B; Rothera, M P

    2012-09-01

    We report a case of rhabdomyosarcoma of the trachea in a 14-month-old child, and we present the first reported use of proton beam therapy for this tumour. A 14-month-old girl presented acutely with a seven-day history of biphasic stridor. Emergency endoscopic debulking of a posterior tracheal mass was undertaken. Histological examination revealed an embryonal rhabdomyosarcoma with anaplasia. Multimodality therapy with surgery and chemotherapy was administered in the UK, and proton beam therapy in the USA. Only three cases of rhabdomyosarcoma of the trachea have previously been reported in the world literature. This is the first reported case of treatment of this tumour with proton beam therapy. Compared with conventional radiotherapy, proton beam therapy may confer improved long-term outcome in children, with benefits including reduced irradiation of the spinal cord.

  13. Beam line optics technologies series (7). Orthopedic treatment of sharp of light (reflecting mirror)

    International Nuclear Information System (INIS)

    Uruga, Tomoya; Nomura, Masaharu

    2006-01-01

    A reflecting mirror (mirror) is the most popular light device for orthopedic treatment of the shape of light. The paper explains the kinds of mirror for hard X-ray field and its applications in order to think the objects of mirror and how to adjust it when user experiment on the beam-line. The basic knowledge of reflection of X-ray, a use of mirror, the kinds of condenser mirror, the influence factors on the condenser size, arrangement of mirror in the hard X-ray beam-line, what kinds of mirror are necessary, evaluation of performance of mirror and adjustment, and troubles and measures are described. Layout in optics hutch at BL01B1 at SPring-8, refraction and total reflection of X-rays at surface, reflectivity of Rh and Pt with ideal surface as a function of photon energy, effects of surface roughness on reflectivity of Rh, calculated beam sizes for typical SPring-8 mirror as a function of magnification, schematic drawing of mirror, standard mirror system for vertical deflection in bending magnet beam-line, and observed and calculated reflectivity of Rh double mirror at BL01B1 at SPring-8 are illustrated. (S.Y)

  14. Cabazitaxel as second-line or third-line therapy in patients with metastatic castration-resistant prostate cancer

    DEFF Research Database (Denmark)

    Kongsted, Per; Svane, Inge M; Lindberg, Henriette

    2016-01-01

    To compare treatment outcomes in patients with metastatic castration-resistant prostate cancer treated with cabazitaxel (CA) as second-line or third-line therapy in the everyday clinical setting. Charts from 94 patients treated with CA as second-line (n=28) or third-line therapy (n=66) were...... evaluated. Common Terminology Criteria for Adverse Events were used to register grade 3-4 nonhematological toxicity during treatment with CA. Baseline metastatic castration-resistant prostate cancer-related prognostic factors, duration of therapy, and maximum prostate-specific antigen (PSA) percentage...... change were registered during treatment with CA and previous/subsequent novel androgen receptor targeting therapies. Progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan-Meier method. A median of 6 versus 5 treatment cycles was administered in patients treated...

  15. Introducing an on-line adaptive procedure for prostate image guided intensity modulate proton therapy.

    Science.gov (United States)

    Zhang, M; Westerly, D C; Mackie, T R

    2011-08-07

    With on-line image guidance (IG), prostate shifts relative to the bony anatomy can be corrected by realigning the patient with respect to the treatment fields. In image guided intensity modulated proton therapy (IG-IMPT), because the proton range is more sensitive to the material it travels through, the realignment may introduce large dose variations. This effect is studied in this work and an on-line adaptive procedure is proposed to restore the planned dose to the target. A 2D anthropomorphic phantom was constructed from a real prostate patient's CT image. Two-field laterally opposing spot 3D-modulation and 24-field full arc distal edge tracking (DET) plans were generated with a prescription of 70 Gy to the planning target volume. For the simulated delivery, we considered two types of procedures: the non-adaptive procedure and the on-line adaptive procedure. In the non-adaptive procedure, only patient realignment to match the prostate location in the planning CT was performed. In the on-line adaptive procedure, on top of the patient realignment, the kinetic energy for each individual proton pencil beam was re-determined from the on-line CT image acquired after the realignment and subsequently used for delivery. Dose distributions were re-calculated for individual fractions for different plans and different delivery procedures. The results show, without adaptive, that both the 3D-modulation and the DET plans experienced delivered dose degradation by having large cold or hot spots in the prostate. The DET plan had worse dose degradation than the 3D-modulation plan. The adaptive procedure effectively restored the planned dose distribution in the DET plan, with delivered prostate D(98%), D(50%) and D(2%) values less than 1% from the prescription. In the 3D-modulation plan, in certain cases the adaptive procedure was not effective to reduce the delivered dose degradation and yield similar results as the non-adaptive procedure. In conclusion, based on this 2D phantom

  16. Second-line systemic therapy for metastatic colorectal cancer.

    Science.gov (United States)

    Mocellin, Simone; Baretta, Zora; Roqué I Figuls, Marta; Solà, Ivan; Martin-Richard, Marta; Hallum, Sara; Bonfill Cosp, Xavier

    2017-01-27

    The therapeutic management of people with metastatic colorectal cancer (CRC) who did not respond to first-line treatment represents a formidable challenge. To determine the efficacy and toxicity of second-line systemic therapy in people with metastatic CRC. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library 2016, Issue 4), Ovid MEDLINE (1950 to May 2016), Ovid MEDLINE In-process & Other Non-Indexed Citations (1946 to May 2016) and Ovid Embase (1974 to May 2016). There were no language or date of publication restrictions. Randomized controlled trials (RCTs) assessing the efficacy (survival, tumour response) and toxicity (incidence of severe adverse effects (SAEs)) of second-line systemic therapy (single or combined treatment with any anticancer drug, at any dose and number of cycles) in people with metastatic CRC that progressed, recurred or did not respond to first-line systemic therapy. Authors performed a descriptive analysis of each included RCT in terms of primary (survival) and secondary (tumour response, toxicity) endpoints. In the light of the variety of drug regimens tested in the included trials, we could carry out meta-analysis considering classes of (rather than single) anticancer regimens; to this aim, we applied the random-effects model to pool the data. We used hazard ratios (HRs) and risk ratios (RRs) to describe the strength of the association for survival (overall (OS) and progression-free survival (PFS)) and dichotomous (overall response rate (ORR) and SAE rate) data, respectively, with 95% confidence intervals (CI). Thirty-four RCTs (enrolling 13,787 participants) fulfilled the eligibility criteria. Available evidence enabled us to address multiple clinical issues regarding the survival effects of second-line systemic therapy of people with metastatic CRC.1. Chemotherapy (irinotecan) was more effective than best supportive care (HR for OS: 0.58, 95% CI 0.43 to 0.80; 1 RCT; moderate-quality evidence); 2

  17. Transmission line analysis of beam deflection in a BPM stripline kicker

    International Nuclear Information System (INIS)

    Caporaso, G.J.; Chen, Yu Ju; Poole, B.

    1997-05-01

    In the usual treatment of impedances of beamline structures the electromagnetic response is computed under the assumption that the source charge trajectory is parallel to the propagation axis and is unaffected by the wake of the structure. For high energy beams of relatively low current this is generally a valid assumption. Under certain conditions the assumption of a parallel source charge trajectory is no longer valid and the effects of the changing trajectory must be included in the analysis. Here the usual transmission line analysis that has been applied to BPM type transverse kickers is extended to include the self-consistent motion of the beam in the structure

  18. An EXAFS spectrometer on beam line 10B at the Photon Factory

    International Nuclear Information System (INIS)

    Oyanagi, Hiroyuki; Matsushita, Tadashi; Ito, Masahisa; Kuroda, Haruo.

    1984-03-01

    An EXAFS spectrometer installed on the beam line 10B at the Photon Factory is designed to cover the photon energy between 4 and 30 keV. Utilizing either a channel-cut or two flat silicon crystals as a monochromator, a beam intensity between 10 8 and 10 9 photons/sec is obtained at 9 keV with a resolution of 1 eV. The performance of the spectrometer, such as a signal-to-noise ratio or an energy resolution is demonstrated with examples of K edge absorption spectra of bromine, germanium, gallium arsenide, and zinc selenide. (author)

  19. Status and Plans for the SPS to LHC Beam Transfer Lines TI 2 and TI 8

    CERN Document Server

    Goddard, B; Risselada, Thys

    2004-01-01

    Beam transfer from the CERN Super Proton Synchrotron (SPS) to the Large Hadron Collider (LHC) will be done through the two transfer lines TI 2 and TI 8, presently under construction, with a combined length of about 5.6 km. The final layout, optics design and correction scheme for these lines will be presented. The requirement of simultaneously matching their geometry and optics with that of the LHC will be treated, including the methodology for alignment of the elements along the line and a proposed solution in the final matching section. After the commissioning of the short transfer line TT40 just upstream of TI 8 in 2003, beam tests of the whole of TI 8 are scheduled for autumn 2004, with the aim to validate many of the new features and mechanisms involved in the future control and operation of these lines. The status of the installation will be described, comprising the progress with infrastructure, services and line elements. An outlook will be given for the work remaining until 2007.

  20. Millimeter-wave Line Ratios and Sub-beam Volume Density Distributions

    Energy Technology Data Exchange (ETDEWEB)

    Leroy, Adam K.; Gallagher, Molly [Department of Astronomy, The Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Usero, Antonio [Observatorio Astronmico Nacional (IGN), C/Alfonso XII, 3, E-28014 Madrid (Spain); Schruba, Andreas [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstraße 1, D-85748 Garching (Germany); Bigiel, Frank [Institute für theoretische Astrophysik, Zentrum für Astronomie der Universität Heidelberg, Albert-Ueberle Str. 2, D-69120 Heidelberg (Germany); Kruijssen, J. M. Diederik; Schinnerer, Eva [Astronomisches Rechen-Institut, Zentrum für Astronomie der Universität Heidelberg, Mönchhofstraße 12-14, D-69120 Heidelberg (Germany); Kepley, Amanda [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903 (United States); Blanc, Guillermo A. [Departamento de Astronomía, Universidad de Chile, Casilla 36-D, Santiago (Chile); Bolatto, Alberto D. [Department of Astronomy, Laboratory for Millimeter-wave Astronomy, and Joint Space Institute, University of Maryland, College Park, MD 20742 (United States); Cormier, Diane; Jiménez-Donaire, Maria J. [Max Planck Institute für Astronomie, Königstuhl 17, D-69117, Heidelberg (Germany); Hughes, Annie [CNRS, IRAP, 9 av. du Colonel Roche, BP 44346, F-31028 Toulouse cedex 4 (France); Rosolowsky, Erik [Department of Physics, University of Alberta, Edmonton, AB (Canada)

    2017-02-01

    We explore the use of mm-wave emission line ratios to trace molecular gas density when observations integrate over a wide range of volume densities within a single telescope beam. For observations targeting external galaxies, this case is unavoidable. Using a framework similar to that of Krumholz and Thompson, we model emission for a set of common extragalactic lines from lognormal and power law density distributions. We consider the median density of gas that produces emission and the ability to predict density variations from observed line ratios. We emphasize line ratio variations because these do not require us to know the absolute abundance of our tracers. Patterns of line ratio variations have the potential to illuminate the high-end shape of the density distribution, and to capture changes in the dense gas fraction and median volume density. Our results with and without a high-density power law tail differ appreciably; we highlight better knowledge of the probability density function (PDF) shape as an important area. We also show the implications of sub-beam density distributions for isotopologue studies targeting dense gas tracers. Differential excitation often implies a significant correction to the naive case. We provide tabulated versions of many of our results, which can be used to interpret changes in mm-wave line ratios in terms of adjustments to the underlying density distributions.

  1. Mechanical Design of a Heavy Ion Beam Dump for the RIA Fragmentation Line

    CERN Document Server

    Stein, Werner; Conner, David L

    2005-01-01

    The RIA fragmentation line requires a beam stop for the primary beam downstream of the first dipole magnet. The beam may consist of U, Ca, Sn, Kr, or O ions. with a variety of power densities. The configuration with highest power density is for the U beam, with a spot size of 3 cm x 3 cm and a total power of up to 300 kW. The mechanical design of the dump that meets these criteria consists of a 50 cm diameter aluminum wheel with water coolant channels. A hollow drive shaft supplies the coolant water and connects the wheel to an electrical motor located in an air space in the floor above the dump. The beam strikes the wheel along the outer perimeter and passes through a thin window of aluminum where 10% of its power is absorbed and the remainder of the beam is absorbed in flowing water behind the window. Rotation of the wheel at 400 RPM results in maximum aluminum temperatures below 100 C and acceptably low thermal stresses of 5 ksi. Rotating the wheel also results in low radiation damage levels by spreading t...

  2. Proton Beam Therapy and Concurrent Chemotherapy for Esophageal Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Steven H., E-mail: shlin@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Komaki, Ritsuko; Liao Zhongxing [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wei, Caimiao [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Myles, Bevan [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Guo Xiaomao [Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai (China); Palmer, Matthew [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mohan, Radhe [Department of Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Swisher, Stephen G.; Hofstetter, Wayne L. [Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Ajani, Jaffer A. [Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Cox, James D. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2012-07-01

    Purpose: Proton beam therapy (PBT) is a promising modality for the management of thoracic malignancies. We report our preliminary experience of treating esophageal cancer patients with concurrent chemotherapy (CChT) and PBT (CChT/PBT) at MD Anderson Cancer Center. Methods and Materials: This is an analysis of 62 esophageal cancer patients enrolled on a prospective study evaluating normal tissue toxicity from CChT/PBT from 2006 to 2010. Patients were treated with passive scattering PBT with two- or three-field beam arrangement using 180 to 250 MV protons. We used the Kaplan-Meier method to assess time-to-event outcomes and compared the distributions between groups using the log-rank test. Results: The median follow-up time was 20.1 months for survivors. The median age was 68 years (range, 38-86). Most patients were males (82%) who had adenocarcinomas (76%) and Stage II-III disease (84%). The median radiation dose was 50.4 Gy (RBE [relative biologic equivalence]) (range, 36-57.6). The most common grade 2 to 3 acute toxicities from CChT/PBT were esophagitis (46.8%), fatigue (43.6%), nausea (33.9%), anorexia (30.1%), and radiation dermatitis (16.1%). There were two cases of grade 2 and 3 radiation pneumonitis and two cases of grade 5 toxicities. A total of 29 patients (46.8%) received preoperative CChT/PBT, with one postoperative death. The pathologic complete response (pCR) rate for the surgical cohort was 28%, and the pCR and near CR rates (0%-1% residual cells) were 50%. While there were significantly fewer local-regional recurrences in the preoperative group (3/29) than in the definitive CChT/PBT group (16/33) (log-rank test, p = 0.005), there were no differences in distant metastatic (DM)-free interval or overall survival (OS) between the two groups. Conclusions: This is the first report of patients treated with PBT/CChT for esophageal cancer. Our data suggest that this modality is associated with a few severe toxicities, but the pathologic response and clinical

  3. Proton Beam Therapy and Concurrent Chemotherapy for Esophageal Cancer

    International Nuclear Information System (INIS)

    Lin, Steven H.; Komaki, Ritsuko; Liao Zhongxing; Wei, Caimiao; Myles, Bevan; Guo Xiaomao; Palmer, Matthew; Mohan, Radhe; Swisher, Stephen G.; Hofstetter, Wayne L.; Ajani, Jaffer A.; Cox, James D.

    2012-01-01

    Purpose: Proton beam therapy (PBT) is a promising modality for the management of thoracic malignancies. We report our preliminary experience of treating esophageal cancer patients with concurrent chemotherapy (CChT) and PBT (CChT/PBT) at MD Anderson Cancer Center. Methods and Materials: This is an analysis of 62 esophageal cancer patients enrolled on a prospective study evaluating normal tissue toxicity from CChT/PBT from 2006 to 2010. Patients were treated with passive scattering PBT with two- or three-field beam arrangement using 180 to 250 MV protons. We used the Kaplan-Meier method to assess time-to-event outcomes and compared the distributions between groups using the log–rank test. Results: The median follow-up time was 20.1 months for survivors. The median age was 68 years (range, 38–86). Most patients were males (82%) who had adenocarcinomas (76%) and Stage II-III disease (84%). The median radiation dose was 50.4 Gy (RBE [relative biologic equivalence]) (range, 36–57.6). The most common grade 2 to 3 acute toxicities from CChT/PBT were esophagitis (46.8%), fatigue (43.6%), nausea (33.9%), anorexia (30.1%), and radiation dermatitis (16.1%). There were two cases of grade 2 and 3 radiation pneumonitis and two cases of grade 5 toxicities. A total of 29 patients (46.8%) received preoperative CChT/PBT, with one postoperative death. The pathologic complete response (pCR) rate for the surgical cohort was 28%, and the pCR and near CR rates (0%–1% residual cells) were 50%. While there were significantly fewer local-regional recurrences in the preoperative group (3/29) than in the definitive CChT/PBT group (16/33) (log–rank test, p = 0.005), there were no differences in distant metastatic (DM)-free interval or overall survival (OS) between the two groups. Conclusions: This is the first report of patients treated with PBT/CChT for esophageal cancer. Our data suggest that this modality is associated with a few severe toxicities, but the pathologic response and

  4. Identification of dental root canals and their medial line from micro-CT and cone-beam CT records

    Directory of Open Access Journals (Sweden)

    Benyó Balázs

    2012-10-01

    Full Text Available Abstract Background Shape of the dental root canal is highly patient specific. Automated identification methods of the medial line of dental root canals and the reproduction of their 3D shape can be beneficial for planning endodontic interventions as severely curved root canals or multi-rooted teeth may pose treatment challenges. Accurate shape information of the root canals may also be used by manufacturers of endodontic instruments in order to make more efficient clinical tools. Method Novel image processing procedures dedicated to the automated detection of the medial axis of the root canal from dental micro-CT and cone-beam CT records are developed. For micro-CT, the 3D model of the root canal is built up from several hundred parallel cross sections, using image enhancement, histogram based fuzzy c-means clustering, center point detection in the segmented slice, three dimensional inner surface reconstruction, and potential field driven curve skeleton extraction in three dimensions. Cone-beam CT records are processed with image enhancement filters and fuzzy chain based regional segmentation, followed by the reconstruction of the root canal surface and detecting its skeleton via a mesh contraction algorithm. Results The proposed medial line identification and root canal detection algorithms are validated on clinical data sets. 25 micro-CT and 36 cone-beam-CT records are used in the validation procedure. The overall success rate of the automatic dental root canal identification was about 92% in both procedures. The algorithms proved to be accurate enough for endodontic therapy planning. Conclusions Accurate medial line identification and shape detection algorithms of dental root canal have been developed. Different procedures are defined for micro-CT and cone-beam CT records. The automated execution of the subsequent processing steps allows easy application of the algorithms in the dental care. The output data of the image processing procedures

  5. Proposal for characterization of muon spectrometers for neutrino beam lines with the Baby MIND

    CERN Document Server

    Noah, E

    2015-01-01

    Neutrino detectors based on state-of-the-art plastic scintillators read out with solid state photo-sensors, as well as new magnetization schemes, have been developed in the framework of AIDA. Meaningful size prototypes are under construction. In the framework of the CERN neutrino platform, we propose to test a Totally Active Scintillator Detector (TASD) and a prototype of a Magnetized Iron Neutrino Detector (MIND), called Baby MIND in the H8 beam line in 2016-2018. The design of the detectors and the purpose and plans for the beam tests are presented. An opportunity to use the Baby MIND detector in a real neutrino beam at JPARC for the measurement of the cross-section ratio between Water and scintillator (WAGASCI experiment) is described.

  6. Power electron beam front shortening in magnetically insulated transmission line with inner coaxial dielectric insert

    International Nuclear Information System (INIS)

    Galstjan, E.A.; Kazanskiy, L.N.

    1995-01-01

    By now the technology of high-power high-current relativistic electron beams with microsecond duration has been developed. The same technology is used in high-power electric pulse generation. However at present the high-power beams of subnanosecond duration are necessary for some investigations and applications. The maximum power parameter achieved by means of the usual technology is limited by a value in the range of 100-300 MW. For this reason a search for new ways to generate high-power REB (relativistic electron beam) is a topical problem. It is obvious that this problem may be reduced to the generation of pulses with a subnanosecond front duration. There are many methods to shorten a pulse duration to its front duration for instance, by using parts of short-circuited transmission lines

  7. High power, high brightness electron beam generation in a pulse-line driven pseudospark discharge

    International Nuclear Information System (INIS)

    Destler, W.W.; Segalov, Z.; Rodgers, J.; Ramaswamy, K.; Reiser, M.

    1993-01-01

    High brightness (∼10 10 A/m 2 rad 2 ), high power density (∼10 10 W/cm 2 ) electron beams have been generated by the mating of a hollow-cathode discharge device operating in the pseudospark regime to the output of a high power pulse line accelerator. Very small diameter (∼1 mm) electron beams with currents in the range 500--1000 A and energies in the range 150--300 keV have been generated with effective emittances estimated to be at or below 170 mm mrad. Such emittances are comparable to those achieved in conventional electron beam sources at current densities several orders of magnitude lower than those observed in these experiments

  8. Application of object oriented techniques in the TRIUMF beam line 2C control system

    International Nuclear Information System (INIS)

    Wilkinson, N.A.; Ludgate, G.A.

    1992-07-01

    The KAON Factory central control system study employed a uniform approach to requirements analysis, architectural design and programming based on well established object oriented principles. These principles were applied to the successful analysis, design and implementation of the control system for the TRIUMF Beam Line 2C Solid Target Facility. The specification for this control system was created in collaboration with Beam Line 2C equipment management experts and, once the analysis models were validated, an approach was developed for the direct translation of these models into C code. A commercial real time database was central to this translation, as inter-object data and control flows are implemented by channels in the database. This paper focuses on the experience gained in the use of object oriented techniques during the complete analysis-design-implementation cycle of a working control system and on the utility of implementing such a system using a commercial real time database and graphical interface. (author)

  9. The Beam Line X NdFe-steel hybrid wiggler for SSRL

    International Nuclear Information System (INIS)

    Hoyer, E.; Halbach, K.; Humphries, D.; Marks, S.; Plate, D.; Shuman, D.; Karpenko, V.P.; Kulkarni, S.; Tirsell, K.G.

    1987-01-01

    A wiggler magnet with 15 periods, each 12.85 cm long, which achieves 1.40 T at a 2.1 cm gap (2.26T at 0.8 cm) has been designed and is now in fabrication at LBL. This wiggler will be the radiation source of the high intensity synchrotron radiation beam line for the Beam Line X PRT facility at SSRL. The magnet utilizes Neodymium-Iron (NdFe) material and Vanadium Permendur (steel) in the hybrid configuration to achieve simultaneously a high magnetic field and short period. Magnetic field adjustment is with a driven chain and ball screw drive system. The magnetic structure is external to an s.s. vacuum chamber which has thin walls, 0.76 mm thickness, at each pole tip for higher field operation. Magnetic design, construction details and magnetic measurements are presented

  10. Selection and evaluation of an ultra high vacuum gate valve for Isabelle beam line vacuum system

    International Nuclear Information System (INIS)

    Foerster, C.L.; McCafferty, D.

    1980-01-01

    A minimum of eighty-four (84) Ultra High Vacuum Gate Valves will be utilized in ISABELLE to protect proton beam lines from catastrophic vacuum failure and to provide sector isolation for maintenance requirements. The valve to be selected must function at less than 1 x 10 -11 Torr pressure and be bakeable to 300 0 C in its open or closed position. In the open position, the valve must have an RF shield to make the beam line walls appear continuous. Several proposed designs were built and evaluated. The evaluation consisted mainly of leak testing, life tests, thermal cycling, mass spectrometer analysis, and 10 -12 Torr operation. Problems with initial design and fabrication were resolved. Special requirements for design and construction were developed. This paper describes the tests on two final prototypes which appear to be the best candidates for ISABELLE operation

  11. Development of an Ethernet enabled microcontroller based module for Superconducting Cyclotron ECR beam line control

    International Nuclear Information System (INIS)

    Chatterjee, M.; Koley, D.; Nabhiraj, P.Y.

    2012-01-01

    An Ethernet enabled control and data acquisition module is developed for remote control and monitoring of the ECR beam line equipment of the Superconducting Cyclotron. The PIC microcontroller based module supports multiple general purpose analog and digital inputs and outputs for interfacing with various equipments and an embedded web server. The remote monitoring and control of the equipment are achieved through the web based user interface. The user authenticated access to control parameters and module configuration parameters ensures the operational safety of the equipment under control. This module is installed in Superconducting Cyclotron ECR beam line for the control and monitoring of vacuum pumping modules, comprising of pumps, gate valves and dual vacuum gauges. The installation of these modules results in a distributed control with localised field cabling and hence better fault diagnosis. (author)

  12. Automated Sample Exchange Robots for the Structural Biology Beam Lines at the Photon Factory

    International Nuclear Information System (INIS)

    Hiraki, Masahiko; Watanabe, Shokei; Yamada, Yusuke; Matsugaki, Naohiro; Igarashi, Noriyuki; Gaponov, Yurii; Wakatsuki, Soichi

    2007-01-01

    We are now developing automated sample exchange robots for high-throughput protein crystallographic experiments for onsite use at synchrotron beam lines. It is part of the fully automated robotics systems being developed at the Photon Factory, for the purposes of protein crystallization, monitoring crystal growth, harvesting and freezing crystals, mounting the crystals inside a hutch and for data collection. We have already installed the sample exchange robots based on the SSRL automated mounting system at our insertion device beam lines BL-5A and AR-NW12A at the Photon Factory. In order to reduce the time required for sample exchange further, a prototype of a double-tonged system was developed. As a result of preliminary experiments with double-tonged robots, the sample exchange time was successfully reduced from 70 seconds to 10 seconds with the exception of the time required for pre-cooling and warming up the tongs

  13. National Synchrotron Light Source users manual: Guide to the VUV and x-ray beam lines

    International Nuclear Information System (INIS)

    Gmuer, N.F.; White-DePace, S.M.

    1987-08-01

    The success of the National Synchrotron Light Source in the years to come will be based, in large part, on the size of the users community and the diversity of the scientific disciplines represented by these users. In order to promote this philosophy, this National Synchrotron Light Source (NSLS) Users Manual: Guide to the VUV and X-Ray Beam Lines, has been published. This manual serves a number of purposes. In an effort to attract new research, it will present to the scientific community-at-large the current and projected architecture and capabilities of the various VUV and x-ray beam lines and storage rings. We anticipate that this publication will be updated periodically in order to keep pace with the constant changes at the NSLS

  14. Preparation of pediatric patients for treatment with proton beam therapy

    International Nuclear Information System (INIS)

    Mizumoto, Masashi; Oshiro, Yoshiko; Ayuzawa, Kaoru; Miyamoto, Toshio; Okumura, Toshiyuki; Fukushima, Takashi; Fukushima, Hiroko; Ishikawa, Hitoshi; Tsuboi, Koji; Sakurai, Hideyuki

    2015-01-01

    Purpose: Anesthesia is often used in proton beam therapy (PBT) for pediatric patients and this may prolong the treatment time. The aim of the study was to examine preparation of pediatric patients to allow smooth performance of PBT. Material and methods: Preparation was initiated 1–2 days before treatment planning CT and continued for 10 days. The patient first visited the facility to become familiar with the treatment room and staff. As the second step, the patient stayed in the treatment bed for a certain time with their mother, and then stayed on the treatment bed alone. Special fixtures painted with characters, music, and gifts were also prepared. Results: From 2010 to 2014, 111 pediatric patients underwent PBT. These patients were divided into 3 groups: 40 who could follow instructions well (group A, median age: 13.6 years old), 60 who could communicate, but found it difficult to stay alone for a long time (group B, median age: 4.6 years old), and 11 who could not follow instructions (group C, median age: 1.6 years old). Preparation was used for patients in group B. The mean treatment times in groups A, B and C were 13.6, 17.1, and 15.6 min, respectively, on PBT treatment days 2–6, and 11.8, 13.0, and 16.9 min, respectively, for the last 5 days of PBT treatment. The time reduction was significant in group B (p = 0.003). Conclusion: Preparation is useful for pediatric patients who can communicate. This approach allows PBT to be conducted more smoothly over a shorter treatment time

  15. Proton beam therapy and accountable care: the challenges ahead.

    Science.gov (United States)

    Elnahal, Shereef M; Kerstiens, John; Helsper, Richard S; Zietman, Anthony L; Johnstone, Peter A S

    2013-03-15

    Proton beam therapy (PBT) centers have drawn increasing public scrutiny for their high cost. The behavior of such facilities is likely to change under the Affordable Care Act. We modeled how accountable care reform may affect the financial standing of PBT centers and their incentives to treat complex patient cases. We used operational data and publicly listed Medicare rates to model the relationship between financial metrics for PBT center performance and case mix (defined as the percentage of complex cases, such as pediatric central nervous system tumors). Financial metrics included total daily revenues and debt coverage (daily revenues - daily debt payments). Fee-for-service (FFS) and accountable care (ACO) reimbursement scenarios were modeled. Sensitivity analyses were performed around the room time required to treat noncomplex cases: simple (30 minutes), prostate (24 minutes), and short prostate (15 minutes). Sensitivity analyses were also performed for total machine operating time (14, 16, and 18 h/d). Reimbursement under ACOs could reduce daily revenues in PBT centers by up to 32%. The incremental revenue gained by replacing 1 complex case with noncomplex cases was lowest for simple cases and highest for short prostate cases. ACO rates reduced this incremental incentive by 53.2% for simple cases and 41.7% for short prostate cases. To cover daily debt payments after ACO rates were imposed, 26% fewer complex patients were allowable at varying capital costs and interest rates. Only facilities with total machine operating times of 18 hours per day would cover debt payments in all scenarios. Debt-financed PBT centers will face steep challenges to remain financially viable after ACO implementation. Paradoxically, reduced reimbursement for noncomplex cases will require PBT centers to treat more such cases over cases for which PBT has demonstrated superior outcomes. Relative losses will be highest for those facilities focused primarily on treating noncomplex cases

  16. Proton Beam Therapy and Accountable Care: The Challenges Ahead

    International Nuclear Information System (INIS)

    Elnahal, Shereef M.; Kerstiens, John; Helsper, Richard S.; Zietman, Anthony L.; Johnstone, Peter A.S.

    2013-01-01

    Purpose: Proton beam therapy (PBT) centers have drawn increasing public scrutiny for their high cost. The behavior of such facilities is likely to change under the Affordable Care Act. We modeled how accountable care reform may affect the financial standing of PBT centers and their incentives to treat complex patient cases. Methods and Materials: We used operational data and publicly listed Medicare rates to model the relationship between financial metrics for PBT center performance and case mix (defined as the percentage of complex cases, such as pediatric central nervous system tumors). Financial metrics included total daily revenues and debt coverage (daily revenues − daily debt payments). Fee-for-service (FFS) and accountable care (ACO) reimbursement scenarios were modeled. Sensitivity analyses were performed around the room time required to treat noncomplex cases: simple (30 minutes), prostate (24 minutes), and short prostate (15 minutes). Sensitivity analyses were also performed for total machine operating time (14, 16, and 18 h/d). Results: Reimbursement under ACOs could reduce daily revenues in PBT centers by up to 32%. The incremental revenue gained by replacing 1 complex case with noncomplex cases was lowest for simple cases and highest for short prostate cases. ACO rates reduced this incremental incentive by 53.2% for simple cases and 41.7% for short prostate cases. To cover daily debt payments after ACO rates were imposed, 26% fewer complex patients were allowable at varying capital costs and interest rates. Only facilities with total machine operating times of 18 hours per day would cover debt payments in all scenarios. Conclusions: Debt-financed PBT centers will face steep challenges to remain financially viable after ACO implementation. Paradoxically, reduced reimbursement for noncomplex cases will require PBT centers to treat more such cases over cases for which PBT has demonstrated superior outcomes. Relative losses will be highest for those

  17. Proton Beam Therapy and Accountable Care: The Challenges Ahead

    Energy Technology Data Exchange (ETDEWEB)

    Elnahal, Shereef M., E-mail: selnahal@partners.org [Department of Medicine, Brigham and Women' s Hospital, Boston, MA (United States); Kerstiens, John [Proton Therapy Center, Indiana University, Bloomington, IN (United States); Helsper, Richard S. [Genesis HealthCare System, Zanesville, OH (United States); Zietman, Anthony L. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); Johnstone, Peter A.S. [Proton Therapy Center, Indiana University, Bloomington, IN (United States); Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN (United States)

    2013-03-15

    Purpose: Proton beam therapy (PBT) centers have drawn increasing public scrutiny for their high cost. The behavior of such facilities is likely to change under the Affordable Care Act. We modeled how accountable care reform may affect the financial standing of PBT centers and their incentives to treat complex patient cases. Methods and Materials: We used operational data and publicly listed Medicare rates to model the relationship between financial metrics for PBT center performance and case mix (defined as the percentage of complex cases, such as pediatric central nervous system tumors). Financial metrics included total daily revenues and debt coverage (daily revenues − daily debt payments). Fee-for-service (FFS) and accountable care (ACO) reimbursement scenarios were modeled. Sensitivity analyses were performed around the room time required to treat noncomplex cases: simple (30 minutes), prostate (24 minutes), and short prostate (15 minutes). Sensitivity analyses were also performed for total machine operating time (14, 16, and 18 h/d). Results: Reimbursement under ACOs could reduce daily revenues in PBT centers by up to 32%. The incremental revenue gained by replacing 1 complex case with noncomplex cases was lowest for simple cases and highest for short prostate cases. ACO rates reduced this incremental incentive by 53.2% for simple cases and 41.7% for short prostate cases. To cover daily debt payments after ACO rates were imposed, 26% fewer complex patients were allowable at varying capital costs and interest rates. Only facilities with total machine operating times of 18 hours per day would cover debt payments in all scenarios. Conclusions: Debt-financed PBT centers will face steep challenges to remain financially viable after ACO implementation. Paradoxically, reduced reimbursement for noncomplex cases will require PBT centers to treat more such cases over cases for which PBT has demonstrated superior outcomes. Relative losses will be highest for those

  18. Experimental studies on coherent synchrotron radiation at an emittance exchange beam line

    Directory of Open Access Journals (Sweden)

    J. C. T. Thangaraj

    2012-11-01

    Full Text Available One of the goals of the Fermilab A0 photoinjector is to investigate experimentally the transverse to longitudinal emittance exchange (EEX principle. Coherent synchrotron radiation in the emittance exchange line could limit the performance of the emittance exchanger at short bunch lengths. In this paper, we present experimental and simulation studies of the coherent synchrotron radiation (CSR in the emittance exchange line at the A0 photoinjector. We report on time-resolved CSR studies using a skew-quadrupole technique. We also demonstrate the advantages of running the EEX with an energy-chirped beam.

  19. Experimental studies on coherent synchrotron radiation at an emittance exchange beam line

    Science.gov (United States)

    Thangaraj, J. C. T.; Thurman-Keup, R.; Ruan, J.; Johnson, A. S.; Lumpkin, A. H.; Santucci, J.

    2012-11-01

    One of the goals of the Fermilab A0 photoinjector is to investigate experimentally the transverse to longitudinal emittance exchange (EEX) principle. Coherent synchrotron radiation in the emittance exchange line could limit the performance of the emittance exchanger at short bunch lengths. In this paper, we present experimental and simulation studies of the coherent synchrotron radiation (CSR) in the emittance exchange line at the A0 photoinjector. We report on time-resolved CSR studies using a skew-quadrupole technique. We also demonstrate the advantages of running the EEX with an energy-chirped beam.

  20. A Monte Carlo-based treatment-planning tool for ion beam therapy

    CERN Document Server

    Böhlen, T T; Dosanjh, M; Ferrari, A; Haberer, T; Parodi, K; Patera, V; Mairan, A

    2013-01-01

    Ion beam therapy, as an emerging radiation therapy modality, requires continuous efforts to develop and improve tools for patient treatment planning (TP) and research applications. Dose and fluence computation algorithms using the Monte Carlo (MC) technique have served for decades as reference tools for accurate dose computations for radiotherapy. In this work, a novel MC-based treatment-planning (MCTP) tool for ion beam therapy using the pencil beam scanning technique is presented. It allows single-field and simultaneous multiple-fields optimization for realistic patient treatment conditions and for dosimetric quality assurance for irradiation conditions at state-of-the-art ion beam therapy facilities. It employs iterative procedures that allow for the optimization of absorbed dose and relative biological effectiveness (RBE)-weighted dose using radiobiological input tables generated by external RBE models. Using a re-implementation of the local effect model (LEM), theMCTP tool is able to perform TP studies u...

  1. Faraday cup dosimetry in a proton therapy beam without collimation

    International Nuclear Information System (INIS)

    Grusell, Erik; Isacsson, Ulf; Montelius, Anders; Medin, Joakim

    1995-01-01

    A Faraday cup in a proton beam can give an accurate measurement of the number of protons collected by the cup. It is shown that the collection efficiency with a proper design can be close to unity. To be able to calibrate an ionization chamber from such a measurement, as is recommended in some dosimetry protocols, the energy spectrum of the proton beam must be accurately known. This is normally not the case when the lateral beam extension is defined by collimators. Therefore a method for relating an ionization chamber measurement in an uncollimated beam to the total number of protons in the beam has been developed and is described together with experimental results from calibrating an ionization chamber using this method in the therapeutic beam in Uppsala. This method is applicable to ionization chambers of any shape and the accuracy is estimated to be 1.6% (1 SD). (Author)

  2. The new vertical neutron beam line at the CERN n-TOF facility design and outlook on the performance

    Energy Technology Data Exchange (ETDEWEB)

    Weiß, C., E-mail: christina.weiss@cern.ch [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Chiaveri, E.; Girod, S.; Vlachoudis, V.; Aberle, O. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Barros, S. [Instituto Tecnológico e Nuclear, Instituto Superior Técnico, Universidade Técnica de Lisboa, Lisboa (Portugal); Bergström, I. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Berthoumieux, E. [Commissariat à l’Énergie Atomique (CEA) Saclay – Irfu, Gif-sur-Yvette (France); Calviani, M. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Guerrero, C.; Sabaté-Gilarte, M. [Universidad de Sevilla (Spain); European Organization for Nuclear Research (CERN), Geneva (Switzerland); Tsinganis, A. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); National Technical University of Athens (NTUA) (Greece); Andrzejewski, J. [Uniwersytet Łódzki, Lodz (Poland); Audouin, L. [Centre National de la Recherche Scientifique/IN2P3 – IPN, Orsay (France); Bacak, M. [Atominstitut, Technische Universität Wien (Austria); Balibrea-Correa, J. [Centro de Investigaciones Energeticas Medioambientales y Tecnológicas (CIEMAT), Madrid (Spain); Barbagallo, M. [Istituto Nazionale di Fisica Nucleare, Bari (Italy); Bécares, V. [Centro de Investigaciones Energeticas Medioambientales y Tecnológicas (CIEMAT), Madrid (Spain); and others

    2015-11-01

    At the neutron time-of-flight facility n-TOF at CERN a new vertical beam line was constructed in 2014, in order to extend the experimental possibilities at this facility to an even wider range of challenging cross-section measurements of interest in astrophysics, nuclear technology and medical physics. The design of the beam line and the experimental hall was based on FLUKA Monte Carlo simulations, aiming at maximizing the neutron flux, reducing the beam halo and minimizing the background from neutrons interacting with the collimator or back-scattered in the beam dump. The present paper gives an overview on the design of the beam line and the relevant elements and provides an outlook on the expected performance regarding the neutron beam intensity, shape and energy resolution, as well as the neutron and photon backgrounds.

  3. Design of active feedback controller used in the infrared beam line of SSRF

    International Nuclear Information System (INIS)

    Zhang Yongli; Tong Yajun; Zhang Zhaohong; Chen Min; Jiang Jianguo; Gong Peirong

    2014-01-01

    Background: The infrared beam line consists of many kinds of optical components that are susceptible to the external mechanical vibration, which will be further amplified by the long optical paths to seriously destroy the stability of infrared beam position. Purpose: The active feedback controller is used to stabilize the infrared beam position disturbed by the external environment. Methods: The design of the active feedback controller used in the infrared beam line of SSRF was proposed in this paper firstly, which included its background, light-path layout and operating process. Subsequently, the selections of the crucial components such as detector and actuator were discussed in details. Finally, the correction compensator design and its experimental test were also presented. The correction compensator design was realized by utilizing the frequency response method, and tested in time domain, frequency domain and mathematical model simulation of the controlled object. Results: The experimental tests included time domain step response signal of the controller, the time domain signal and its relevant magnitude spectrum in frequency domain due to the light source simulation vibration. Conclusion: The results show that the maximum effective operating band is 250 Hz and the maximum steady error is 5 μm. (authors)

  4. An electrostatic beam line for accelerator mass spectroscopy of exotic particles

    International Nuclear Information System (INIS)

    Elmore, D.; Kubik, P.W.; Hemmick, T.; Teng, R.; Kagan, H.; Haas, P.; Boyd, R.N.; Turner, R.; Nitz, D.; Ciampa, D.; Olsen, S.L.; Gentile, T.; Haelen, T.

    1985-01-01

    An all-electrostatic charged particle spectrometer has been constructed to perform high sensitivity searches for exotic states of matter. This spectrometer consists of an electrosatic beam line capable of mass independent charged particle transport and selection together with time-of-flight, energy loss and total energy detectors. This system has been used in conjunction with the tandem electrostatic accelerator at the Nuclear Structure Research Laboratory of the University of Rochester to search for fractionally charged or anomalously heavy particles. (orig.)

  5. The development of an expert system to tune a beam line

    International Nuclear Information System (INIS)

    Schultz, D.E.; Brown, P.A.; British Columbia Univ., Vancouver, BC

    1989-01-01

    The experience of developing an Expert System to aid in the tuning of the Ion Source Injection beam line at TRIUMF is described. The challenging and complex task of introducing Expert System technology into an established accelerator operation is outlined. Success in this environment depends strongly on the choice of project, the choice of experts, the choice of tools, and the methods used to represent the expertise. All these choices are discussed

  6. Beam dynamics study in the C235 cyclotron for proton therapy

    International Nuclear Information System (INIS)

    Karamysheva, G.A.; Kostromin, S.A.

    2008-01-01

    Study of the beam dynamics in the C235 cyclotron dedicated to the proton therapy is presented. Results of the computer simulations of the particle motion in the measured magnetic field are given. Study of the resonance influence on the acceleration process was carried out. The corresponding tolerances on the magnetic field imperfections and transverse beam parameters were defined using these simulations

  7. Design of x-ray diagnostic beam line for a synchrotron radiation source and measurement results

    Energy Technology Data Exchange (ETDEWEB)

    Garg, Akash Deep, E-mail: akash-deep@rrcat.gov.in; Karnewar, A.K.; Ojha, A.; Shrivastava, B.B.; Holikatti, A.C.; Puntambekar, T.A.; Navathe, C.P.

    2014-08-01

    Indus-2 is a 2.5 GeV synchrotron radiation source (SRS) operational at the Raja Ramanna Centre for Advanced Technology (RRCAT) in India. We have designed, developed and commissioned x-ray diagnostic beam line (X-DBL) at the Indus-2. It is based on pinhole array imaging (8–18 keV). We have derived new equations for online measurements of source position and emission angle with pinhole array optics. Measured values are compared with the measurements at an independent x-ray beam position monitor (staggered pair blade monitor) installed in the X-DBL. The measured values are close to the theoretical expected values within ±12 µm (or ±1.5 μrad) for sufficiently wide range of the beam movements. So, beside the beam size and the beam emittance, online information for the vertical position and angle is also used in the orbit steering. In this paper, the various design considerations of the X-DBL and online measurement results are presented.

  8. Improved design of proton source and low energy beam transport line for European Spallation Source

    Energy Technology Data Exchange (ETDEWEB)

    Neri, L., E-mail: neri@lns.infn.it; Celona, L.; Gammino, S.; Mascali, D.; Castro, G.; Ciavola, G. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, 95123 Catania (Italy); Torrisi, G. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, 95123 Catania (Italy); Dipartimento di Ingegneria dell’Informazione, delle Infrastrutture e dell’Energia Sostenibile, Università Mediterranea di Reggio Calabria, Via Graziella, 89122 Reggio Calabria (Italy); Cheymol, B.; Ponton, A. [European Spallation Source ESS AB, Lund (Sweden); Galatà, A. [Laboratori Nazionali di Legnaro, Istituto Nazionale di Fisica Nucleare, Viale dell' università 2, 35020 Legnaro (Italy); Patti, G. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, 95123 Catania (Italy); Laboratori Nazionali di Legnaro, Istituto Nazionale di Fisica Nucleare, Viale dell' università 2, 35020 Legnaro (Italy); Gozzo, A.; Lega, L. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Via S. Sofia 62, 95123 Catania (Italy); Dipartimento di Ingegneria Informatica e delle Telecomunicazioni, Università degli Studi di Catania, Viale Andrea Doria 6, 95123 Catania (Italy)

    2014-02-15

    The design update of the European Spallation Source (ESS) accelerator is almost complete and the construction of the prototype of the microwave discharge ion source able to provide a proton beam current larger than 70 mA to the 3.6 MeV Radio Frequency Quadrupole (RFQ) started. The source named PS-ESS (Proton Source for ESS) was designed with a flexible magnetic system and an extraction system able to merge conservative solutions with significant advances. The ESS injector has taken advantage of recent theoretical updates and new plasma diagnostics tools developed at INFN-LNS (Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare). The design strategy considers the PS-ESS and the low energy beam transport line as a whole, where the proton beam behaves like an almost neutralized non-thermalized plasma. Innovative solutions have been used as hereinafter described. Thermo-mechanical optimization has been performed to withstand the chopped beam and the misaligned focused beam over the RFQ input collimator; the results are reported here.

  9. SU-C-207A-06: On-Line Beam Range Verification with Multiple Scanning Particle Beams: Initial Feasibility Study with Simulations

    Energy Technology Data Exchange (ETDEWEB)

    Zhong, Y; Sun, X; Lu, W; Jia, X; Wang, J; Shao, Y [The University of Texas Southwestern Medical Ctr., Dallas, TX (United States)

    2016-06-15

    Purpose: To investigate the feasibility and requirement for intra-fraction on-line multiple scanning particle beam range verifications (BRVs) with in-situ PET imaging, which is beyond the current single-beam BRV with extra factors that will affect the BR measurement accuracy, such as beam diameter, separation between beams, and different image counts at different BRV positions. Methods: We simulated a 110-MeV proton beam with 5-mm diameter irradiating a uniform PMMA phantom by GATE simulation, which generated nuclear interaction-induced positrons. In this preliminary study, we simply duplicated these positrons and placed them next to the initial protons to approximately mimic the two spatially separated positron distributions produced by two beams parallel to each other but with different beam ranges. These positrons were then imaged by a PET (∼2-mm resolution, 10% sensitivity, 320×320×128 mm^3 FOV) with different acquisition times. We calculated the positron activity ranges (ARs) from reconstructed PET images and compared them with the corresponding ARs of original positron distributions. Results: Without further image data processing and correction, the preliminary study show the errors between the measured and original ARs varied from 0.2 mm to 2.3 mm as center-to-center separations and range differences were in the range of 8–12 mm and 2–8 mm respectively, indicating the accuracy of AR measurement strongly depends on the beam separations and range differences. In addition, it is feasible to achieve ≤ 1.0-mm accuracy for both beams with 1-min PET acquisition and 12 mm beam separation. Conclusion: This study shows that the overlap between the positron distributions from multiple scanning beams can significantly impact the accuracy of BRVs of distributed particle beams and need to be further addressed beyond the established method of single-beam BRV, but it also indicates the feasibility to achieve accurate on-line multi-beam BRV with further improved

  10. Third-line therapy in recurrent glioblastoma: is it another chance for bevacizumab?

    Science.gov (United States)

    Franceschi, Enrico; Lamberti, Giuseppe; Paccapelo, Alexandro; Di Battista, Monica; Genestreti, Giovenzio; Minichillo, Santino; Mura, Antonella; Bartolini, Stefania; Agati, Raffaele; Brandes, Alba A

    2018-04-18

    Standard glioblastoma therapy is long-lasting. Among second-line therapy, choices could be bevacizumab and nitrosoureas depending on National Agencies approval. There is no consensus on 3rd line therapy or clinical trials specifically designed for this setting. We reviewed our institutional database on all consecutive patients who received 3rd line therapy for glioblastoma. Data on 168 out of 1337 (12.6%) glioblastoma patients who underwent 3rd line therapy treatment were collected. Third line treatments were bevacizumab or chemotherapy (nitrosourea, temozolomide or carboplatin plus etoposide). Median progression free survival was 2.9 months and median survival time was 6.6 months from the start of 3rd line therapy. Bevacizumab significantly improved progression-free survival (4.7 vs. 2.6 months, p = .020) and survival from 3rd line start (8.0 vs. 6.0 months, p = .014) in respect to chemotherapy. Toxicity of grade ≥ 3 occurred in 13.7% of patients. In multivariate analysis, survival in 3rd line treatment depends on MGMT methylation (p = .006) and treatment with Bevacizumab (p = .011). Third line therapy in selected glioblastoma patients may be feasible and well tolerated. Bevacizumab improved outcome in 3rd line in respect to chemotherapy.

  11. The FLUKA code for application of Monte Carlo methods to promote high precision ion beam therapy

    CERN Document Server

    Parodi, K; Cerutti, F; Ferrari, A; Mairani, A; Paganetti, H; Sommerer, F

    2010-01-01

    Monte Carlo (MC) methods are increasingly being utilized to support several aspects of commissioning and clinical operation of ion beam therapy facilities. In this contribution two emerging areas of MC applications are outlined. The value of MC modeling to promote accurate treatment planning is addressed via examples of application of the FLUKA code to proton and carbon ion therapy at the Heidelberg Ion Beam Therapy Center in Heidelberg, Germany, and at the Proton Therapy Center of Massachusetts General Hospital (MGH) Boston, USA. These include generation of basic data for input into the treatment planning system (TPS) and validation of the TPS analytical pencil-beam dose computations. Moreover, we review the implementation of PET/CT (Positron-Emission-Tomography / Computed- Tomography) imaging for in-vivo verification of proton therapy at MGH. Here, MC is used to calculate irradiation-induced positron-emitter production in tissue for comparison with the +-activity measurement in order to infer indirect infor...

  12. Role of beam orientation optimization in intensity-modulated radiation therapy

    International Nuclear Information System (INIS)

    Pugachev, Andrei; Li, Jonathan G.; Boyer, Arthur L.; Hancock, Steven L.; Le, Quynh-Thu; Donaldson, Sarah S.; Lei Xing

    2001-01-01

    Purpose: To investigate the role of beam orientation optimization in intensity-modulated radiation therapy (IMRT) and to examine the potential benefits of noncoplanar intensity-modulated beams. Methods and Materials: A beam orientation optimization algorithm was implemented. For this purpose, system variables were divided into two groups: beam position (gantry and table angles) and beam profile (beamlet weights). Simulated annealing was used for beam orientation optimization and the simultaneous iterative inverse treatment planning algorithm (SIITP) for beam intensity profile optimization. Three clinical cases were studied: a localized prostate cancer, a nasopharyngeal cancer, and a paraspinal tumor. Nine fields were used for all treatments. For each case, 3 types of treatment plan optimization were performed: (1) beam intensity profiles were optimized for 9 equiangular spaced coplanar beams; (2) orientations and intensity profiles were optimized for 9 coplanar beams; (3) orientations and intensity profiles were optimized for 9 noncoplanar beams. Results: For the localized prostate case, all 3 types of optimization described above resulted in dose distributions of a similar quality. For the nasopharynx case, optimized noncoplanar beams provided a significant gain in the gross tumor volume coverage. For the paraspinal case, orientation optimization using noncoplanar beams resulted in better kidney sparing and improved gross tumor volume coverage. Conclusion: The sensitivity of an IMRT treatment plan with respect to the selection of beam orientations varies from site to site. For some cases, the choice of beam orientations is important even when the number of beams is as large as 9. Noncoplanar beams provide an additional degree of freedom for IMRT treatment optimization and may allow for notable improvement in the quality of some complicated plans

  13. SU-E-T-577: Obliquity Factor and Surface Dose in Proton Beam Therapy

    International Nuclear Information System (INIS)

    Das, I; Andersen, A; Coutinho, L

    2015-01-01

    Purpose: The advantage of lower skin dose in proton beam may be diminished creating radiation related sequalae usually seen with photon and electron beams. This study evaluates the surface dose as a complex function of beam parameters but more importantly the effect of beam angle. Methods: Surface dose in proton beam depends on the beam energy, source to surface distance, the air gap between snout and surface, field size, material thickness in front of surface, atomic number of the medium, beam angle and type of nozzle (ie double scattering, (DS), uniform scanning (US) or pencil beam scanning (PBS). Obliquity factor (OF) is defined as ratio of surface dose in 0° to beam angle Θ. Measurements were made in water phantom at various beam angles using very small microdiamond that has shown favorable beam characteristics for high, medium and low proton energy. Depth dose measurements were performed in the central axis of the beam in each respective gantry angle. Results: It is observed that surface dose is energy dependent but more predominantly on the SOBP. It is found that as SSD increases, surface dose decreases. In general, SSD, and air gap has limited impact in clinical proton range. High energy has higher surface dose and so the beam angle. The OF rises with beam angle. Compared to OF of 1.0 at 0° beam angle, the value is 1.5, 1.6, 1,7 for small, medium and large range respectively for 60 degree angle. Conclusion: It is advised that just like range and SOBP, surface dose should be clearly understood and a method to reduce the surface dose should be employed. Obliquity factor is a critical parameter that should be accounted in proton beam therapy and a perpendicular beam should be used to reduce surface dose

  14. A high intensity beam line of γ-rays up to 22MeV energy based on Compton backscattering

    International Nuclear Information System (INIS)

    Guo, W.; Xu, W.; Chen, J.G.; Ma, Y.G.; Cai, X.Z.; Wang, H.W.; Xu, Y.; Wang, C.B.; Lu, G.C.; Tian, W.D.; Yuan, R.Y.; Xu, J.Q.; Wei, Z.Y.; Yan, Z.; Shen, W.Q.

    2007-01-01

    Shanghai Laser Electron Gamma Source, a high intensity beam line of γ-ray, has been proposed recently. The beam line is expected to generate γ-rays up to the maximum energy of 22MeV by Compton backscattering between a CO 2 laser and electrons in the 3.5 GeV storage ring of the Shanghai Synchrotron Radiation Facility. The flux of non-collimated γ-rays is estimated to be 10 9 -10 10 s -1 when a CO 2 laser of several hundred Watt power is employed. We will discuss physics issues in the design and optimization of the beam line

  15. Opening and construction of facilities in succession for particle beam therapy of cancer

    International Nuclear Information System (INIS)

    Nakano, Takashi; Yamamoto, Kazutaka; Hishikawa, Yoshio; Totoki, Tadahide; Hoshino, Junichi; Aoki, Takashi; Yoshiyuki, Takeshi; Hirabayashi, Masayuki; Nakamura, Fumito

    2011-01-01

    This feature article describes the current state of practical particle beam therapy of cancer, its future prospect, recent opening/construction of its facilities and manufacturers' view with following 9 topics presented by relevant experts. Gunma University (topic 1) started the carbon ion therapy from Mar., 2010, and has treated more than 100 cancer patients to aim the treatment of about 600 patients/year after several years. Fukui Prefectural Hospital Proton Therapy Center (topic 2) started from this March with proton beams for patients with its therapeutic standard, in cooperation with insurance companies and hotels for patients' convenience. Medipolis Proton Therapy and Research Center (Kagoshima Pref.) (topic 3) started this year with proton beams for 13 patients hitherto with reference protocol of Hyogo Ion Beam Medical Center. A new stereotactic irradiation system of proton beams for breast cancer has been developed. Construction of Saga Heavy Ion Medical Accelerator in Tosu (Saga Pref.) (topic 4) began this year to be completed in 2013. Aizawa Hospital (Nagano Pref.) (topic 5) plans to introduce the small-sized proton accelerator-gantry system (Sumitomo Heavy Ind., Ltd.) aiming the practice in 2013. Association for Nuclear Technology in Medicine (topic 6) reports the trends of current and future construction inside/outside Japan. Manufacturers comment their respective business: high-speed scanning irradiation system, next generation handling system of patient and particle beam therapy information system by Toshiba (topic 7); designation of the whole heavy ion beam therapy system (with NIRS), proton beam (as in topic 5) and system of BNCT (boron neutron-capture therapy) (Kyoto Univ.) by Sumitomo Heavy Ind., Ltd. (topic 8); and small-size proton therapeutic machine with 4D tracing capability for patient's movement (Hokkaido Univ.) and with spot-scanning irradiation technique by Hitachi (topic 9). (author)

  16. A prospective, open-label study of low-dose total skin electron beam therapy in mycosis fungoides

    DEFF Research Database (Denmark)

    Kamstrup, Maria R; Specht, Lena; Skovgaard, Gunhild L

    2008-01-01

    causes and did not complete treatment. Acute side effects included desquamation, xerosis, and erythema of the skin. No severe side effects were observed. CONCLUSION: Low-dose total skin electron beam therapy can induce complete and partial responses in Stage IB-II mycosis fungoides; however, the duration......PURPOSE: To determine the effect of low-dose (4 Gy) total skin electron beam therapy as a second-line treatment of Stage IB-II mycosis fungoides in a prospective, open-label study. METHODS AND MATERIALS: Ten patients (6 men, 4 women, average age 68.7 years [range, 55-82 years......]) with histopathologically confirmed mycosis fungoides T2-T4 N0-N1 M0 who did not achieve complete remission or relapsed within 4 months after treatment with psoralen plus ultraviolet-A were included. Treatment consisted of low-dose total skin electron beam therapy administered at a total skin dose of 4 Gy given in 4...

  17. Beam transport radiation shielding for branch lines 2-ID-B and 2-ID-C

    International Nuclear Information System (INIS)

    Feng, Y.P.; Lai, B.; McNulty, I.; Dejus, R.J.; Randall, K.J.; Yun, W.

    1995-01-01

    The x-ray radiation shielding requirements beyond the first optics enclosure have been considered for the beam transport of the 2-ID-B and 2-ID-C branch lines of Sector 2 (SRI-CAT) of the APS. The first three optical components (mirrors) of the 2-ID-B branch are contained within the shielded first optics enclosure. Calculations indicate that scattering of the primary synchrotron beam by beamline components outside the enclosure, such as apertures and monochromators, or by gas particles in case of vacuum failure is within safe limits for this branch. A standard 2.5-inch-diameter stainless steel pipe with 1/16-inch-thick walls provides adequate shielding to reduce the radiation dose equivalent rate to human tissue to below the maximum permissible limit of 0.25 mrem/hr. The 2-ID-C branch requires, between the first optics enclosure where only two mirrors are used and the housing for the third mirror, additional lead shielding (0.75 mm) and a minimum approach distance of 2.6 cm. A direct beam stop consisting of at least 4.5 mm of lead is also required immediately downstream of the third mirror for 2-ID-C. Finally, to stop the direct beam from escaping the experimental station, a beam stop consisting of at least 4-mm or 2.5-mm steel is required for the 2-ID-B or 2-ID-C branches, respectively. This final requirement can be met by the vacuum chambers used to house the experiments for both branch lines

  18. Imaging and characterization of primary and secondary radiation in ion beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Granja, Carlos, E-mail: carlos.granja@utef.cvut.cz; Opalka, Lukas [Institute of Experimental and Applied Physics, Czech Technical University in Prague (Czech Republic); Martisikova, Maria; Gwosch, Klaus [German Cancer Research Center, Heidelberg (Germany); Jakubek, Jan [Advacam, Prague (Czech Republic)

    2016-07-07

    Imaging in ion beam therapy is an essential and increasingly significant tool for treatment planning and radiation and dose deposition verification. Efforts aim at providing precise radiation field characterization and online monitoring of radiation dose distribution. A review is given of the research and methodology of quantum-imaging, composition, spectral and directional characterization of the mixed-radiation fields in proton and light ion beam therapy developed by the IEAP CTU Prague and HIT Heidelberg group. Results include non-invasive imaging of dose deposition and primary beam online monitoring.

  19. Imaging and characterization of primary and secondary radiation in ion beam therapy

    International Nuclear Information System (INIS)

    Granja, Carlos; Opalka, Lukas; Martisikova, Maria; Gwosch, Klaus; Jakubek, Jan

    2016-01-01

    Imaging in ion beam therapy is an essential and increasingly significant tool for treatment planning and radiation and dose deposition verification. Efforts aim at providing precise radiation field characterization and online monitoring of radiation dose distribution. A review is given of the research and methodology of quantum-imaging, composition, spectral and directional characterization of the mixed-radiation fields in proton and light ion beam therapy developed by the IEAP CTU Prague and HIT Heidelberg group. Results include non-invasive imaging of dose deposition and primary beam online monitoring.

  20. Present status and first results of the final focus beam line at the KEK Accelerator Test Facility

    Directory of Open Access Journals (Sweden)

    2010-04-01

    Full Text Available ATF2 is a final-focus test beam line which aims to focus the low emittance beam from the ATF damping ring to a vertical size of about 37 nm and to demonstrate nanometer level beam stability. Several advanced beam diagnostics and feedback tools are used. In December 2008, construction and installation were completed and beam commissioning started, supported by an international team of Asian, European, and U.S. scientists. The present status and first results are described.

  1. A technique for transferring a patient's smile line to a cone beam computed tomography (CBCT) image.

    Science.gov (United States)

    Bidra, Avinash S

    2014-08-01

    Fixed implant-supported prosthodontic treatment for patients requiring a gingival prosthesis often demands that bone and implant levels be apical to the patient's maximum smile line. This is to avoid the display of the prosthesis-tissue junction (the junction between the gingival prosthesis and natural soft tissues) and prevent esthetic failures. Recording a patient's lip position during maximum smile is invaluable for the treatment planning process. This article presents a simple technique for clinically recording and transferring the patient's maximum smile line to cone beam computed tomography (CBCT) images for analysis. The technique can help clinicians accurately determine the need for and amount of bone reduction required with respect to the maximum smile line and place implants in optimal positions. Copyright © 2014 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  2. Proton beam therapy: reliability of the synchrocyclotron at the Harvard Cyclotron Laboratory

    International Nuclear Information System (INIS)

    Sisterson, J.M.; Cascio, E.; Koehler, A.M.; Johnson, K.N.

    1991-01-01

    The reliability of the synchrocyclotron at Harvard Cyclotron Laboratory has been studied over the period 1980-1989 to see if proton beam therapy can compare in reliability to linear accelerators used in radiation therapy departments. Breakdowns in relation to patient load are reviewed in outline. (U.K.)

  3. Expanded beam spectro-ellipsometry for big area on-line monitoring

    Science.gov (United States)

    Fried, M.; Major, C.; Juhasz, G.; Petrik, P.; Horvath, Z.

    2015-05-01

    Non-destructive analysing tools are needed at all stages of thin film process-development, especially photovoltaic (PV) development, and on production lines. In the case of thin films, layer thicknesses, micro-structure, composition, layer optical properties, and their uniformity are important parameters. An important focus is to express the dielectric functions of each component material in terms of a handful of wavelength independent parameters whose variation can cover all process variants of that material. With the resulting database, spectroscopic ellipsometry coupled with multilayer analysis can be developed for on-line point-by-point mapping and on-line line-by-line imaging. Off-line point-by-point mapping can be effective for characterization of non-uniformities in full scale PV panels or big area (even 450 mm diameter) Si-wafers in developing labs but it is slow in the on-line mode when only 15 points can be obtained (within 1 min) as a 120 cm long panel moves by the mapping station. Last years [M. Fried et al, Thin Solid Films 519, 2730 (2011)], a new instrumentation was developed that provides a line image of spectroscopic ellipsometry (wl=350- 1000 nm) data. Earlier a single 30 point line image could be collected in 10 s over a 15 cm width of PV material. Recent years we have built a 30, a 45 and a 60 cm width expanded beam ellipsometer which speed is increased by 10x. Now, 1800 points can be mapped in a 1 min traverse of a 60*120 cm PV panel or flexible roll-to-roll substrate.

  4. Novel imaging and quality assurance techniques for ion beam therapy a Monte Carlo study

    CERN Document Server

    Rinaldi, I; Jäkel, O; Mairani, A; Parodi, K

    2010-01-01

    Ion beams exhibit a finite and well defined range in matter together with an “inverted” depth-dose profile, the so-called Bragg peak. These favourable physical properties may enable superior tumour-dose conformality for high precision radiation therapy. On the other hand, they introduce the issue of sensitivity to range uncertainties in ion beam therapy. Although these uncertainties are typically taken into account when planning the treatment, correct delivery of the intended ion beam range has to be assured to prevent undesired underdosage of the tumour or overdosage of critical structures outside the target volume. Therefore, it is necessary to define dedicated Quality Assurance procedures to enable in-vivo range verification before or during therapeutic irradiation. For these purposes, Monte Carlo transport codes are very useful tools to support the development of novel imaging modalities for ion beam therapy. In the present work, we present calculations performed with the FLUKA Monte Carlo code and pr...

  5. Performance and beam characteristics of the PANTAK THERAPAX HF225 X-ray therapy machine

    Energy Technology Data Exchange (ETDEWEB)

    Yiannakkaras, C; Papadopoulos, N; Christodoulides, G [Department of Medical Physics, Nicosia General Hospital, 1450 Nicosia (Cyprus)

    1999-12-31

    The performance and beam characteristics of the new PANTAK THERAPAX HF225 X-ray therapy machine have been measured, evaluated and discussed. Eight beam qualities within the working range of generating potentials between 50 and 225 kVp are used in our department. These beam qualities have been investigated in order to provide a data base specific to our machine. Beam Quality, Central Axis Depth Dose, Output, Relative Field Uniformity and Timer Error were investigated. (authors) 11 refs., 4 figs., 9 tabs.

  6. Potential clinical impact of laser-accelerated beams in cancer ion therapy

    Energy Technology Data Exchange (ETDEWEB)

    Obcemea, Ceferino

    2016-09-01

    In this article, I present three advantages of plasma-accelerated ion beams for cancer therapy. I discuss how: 1. low-emittance and well-collimated beams are advantageous in proximal normal tissue-sparing; 2. highly-peaked quasi-monoenergetic beams are ideal for fast energy selection and switching in Pencil Beam Scanning (PBS) as a treatment delivery; 3. high fluence and ultra-short pulse delivery produce collective excitations in the medium and enhance the stopping power. This in turn produces denser ionization track signatures (spurs, blobs, etc.) in target tumors, higher linear energy transfer, higher Bragg peak, and higher radiobiological effectiveness at the micro-level.

  7. Heat flux estimation for neutral beam line components using inverse heat conduction procedures

    International Nuclear Information System (INIS)

    Bharathi, P.; Prahlad, V.; Quereshi, K.; Bansal, L.K.; Rambabu, S.; Sharma, S.K.; Parmar, S.; Patel, P.J.; Baruah, U.K.; Patel, Ravi

    2015-01-01

    In this work, we describe and compare the analytical IHCP methods such-as semi-infinite method, finite slab method and a numerical method called Stolz method for estimating the incident heat flux from the experimentally measured temperature data. In case of analytical methods, the finite time response of the sensor is needed to be accounted for an accurate power density estimations. The modified models corrected for the response time of the sensors are also discussed in this paper. Application of these methods using example temperature waveforms obtained on the SST1-NBI test stand is presented and discussed. For choosing the suitable method for the calorimetry on beam line components, the estimated results are also validated using the ANSYS analysis done on these beam Iine components. As a conclusion, the finite slab method corrected for the influence of the sensor response time found out to be the most suitable method for the inversion of temperature data in case of neutral beam line components

  8. Proposed particle-beam characterizations for the APS undulator test line

    Energy Technology Data Exchange (ETDEWEB)

    Lumpkin, A.H.; Borland, M.; Milton, S.

    1993-09-01

    A research and development effort is underway at the Advanced Photon Source (APS) to use an rf gun as a low-emittance electron source for injection into the 100- to 650-MeV linac subsystem and subsequently to an undulator test area. This configuration would combine the acceleration capability of the 200-MeV S-band electron linac and the in-line 450-MeV positron linac that normally provide positrons to the positron accumulator ring (PAR). A transport line that bypasses the PAR will bring the electrons to the undulator test area. Characterization techniques will be discussed for the electron beam with a normalized, rms emittance of <10 {pi} mm mrad (1{sigma}) at micropulse charges of up to 350 pC and micropulse durations of {approximately}5 ps (FWHM). Tests proposed include measurement of particle beam transport effects (at one-tenth the storage ring beam rigidity) caused by small undulator field errors as well as operations intended to produce coherent, short wavelength radiation (<200 nm).

  9. Dosimetry of beams for negative pi-meson radiation therapy

    International Nuclear Information System (INIS)

    Dicello, J.F.

    1976-01-01

    Several new facilities have been built in the last few years which can produce high intensity beams of pions. As a result, a significant amount of new data related to pion dosimetry is available. Results of beam composition, beam shaping, and collimation are given along with depth dose curves and isodose contours. Experimental data which describe the radiation quality of pion beams and the change in radiation quality with position are presented. Experimental data determining the fraction of the dose resulting from neutrons are discussed. The present techniques used in pion dosimetry are summarized, and those areas of pion dosimetry which require additional effort in order to achieve routine treatment planning for patients are reviewed

  10. Experimental verification of the CLIC Decelerator with the test Beam Line in the CLIC test facility 3

    CERN Document Server

    Lillestøl, R L; Olvegård, M; Rabiller, A N; Sterbini, G; Adli, E

    2012-01-01

    The Test Beam Line in the CLIC Test Facility 3 is the first prototype of the CLIC drive beam decelerator. The main purpose of the experiment is to demonstrate efficient 12 GHz rf power production and stable transport of an electron drive beam during deceleration. The Test Beam Line consists of a FODO structure with high precision BPMs and quadrupoles mounted on mechanical movers for precisebeam alignment. Nine out of the planned 16 Power Extraction and Transfer Structures have currently been installed and commissioned. We correlate rf power production measurements with the drive beam deceleration measurements, and compare the two measurements to the theoretical predictions. We also discuss the impact of the drive beam bunch length and bunch combination on the measurements.

  11. Accelerator Based Neutron Beams for Neutron Capture Therapy

    International Nuclear Information System (INIS)

    Yanch, Jacquelyn C.

    2003-01-01

    The DOE-funded accelerator BNCT program at the Massachusetts Institute of Technology has resulted in the only operating accelerator-based epithermal neutron beam facility capable of generating significant dose rates in the world. With five separate beamlines and two different epithermal neutron beam assemblies installed, we are currently capable of treating patients with rheumatoid arthritis in less than 15 minutes (knee joints) or 4 minutes (finger joints) or irradiating patients with shallow brain tumors to a healthy tissue dose of 12.6 Gy in 3.6 hours. The accelerator, designed by Newton scientific Incorporated, is located in dedicated laboratory space that MIT renovated specifically for this project. The Laboratory for Accelerator Beam Applications consists of an accelerator room, a control room, a shielded radiation vault, and additional laboratory space nearby. In addition to the design, construction and characterization of the tandem electrostatic accelerator, this program also resulted in other significant accomplishments. Assemblies for generating epithermal neutron beams were designed, constructed and experimentally evaluated using mixed-field dosimetry techniques. Strategies for target construction and target cooling were implemented and tested. We demonstrated that the method of submerged jet impingement using water as the coolant is capable of handling power densities of up to 6 x 10(sup 7) W/m(sup 2) with heat transfer coefficients of 10(sup 6)W/m(sup 2)-K. Experiments with the liquid metal gallium demonstrated its superiority compared with water with little effect on the neutronic properties of the epithermal beam. Monoenergetic proton beams generated using the accelerator were used to evaluate proton RBE as a function of LET and demonstrated a maximum RBE at approximately 30-40 keV/um, a finding consistent with results published by other researchers. We also developed an experimental approach to biological intercomparison of epithermal beams and

  12. Alignment of dipole magnet in micro-beam line of HIRFL

    International Nuclear Information System (INIS)

    Wang Shaoming; Chen Wenjun; Yang Shengli; Cai Guozhu; Guo Yizhen; Zhou Guangming; Man Kaidi; Song Mingtao

    2010-01-01

    Microbeam irradiation facility is an experiment platform, which can reduce the beam-spot on the irradiated sample to micrometer level, and can accurately locate and count the radioactive particles. It is a powerful research tool for the irradiation material science, irradiation biology, irradiation biomedicine and micro mechanical machining. The microbeam irradiation facility requires the precise work for installation and alignment. These conditions make magnet's change for directions and positions because the location space of dipole magnets in micro-beam line of HIRFL (Heavy Ion Research Facility in Lanzhou) is very small. It is a challenge for the installation and alignment work of magnets. It was solved by transforming coordinates of benchmarks of magnets, which controlled the error of magnet setup within error tolerance range. (authors)

  13. Target and orbit feedback simulations of a muSR beam line at BNL

    Energy Technology Data Exchange (ETDEWEB)

    MacKay, W. [Brookhaven National Lab. (BNL), Upton, NY (United States); Blaskiewicz, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Fischer, W. [Brookhaven National Lab. (BNL), Upton, NY (United States); Pile, P. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-07-28

    Well-polarized positive surface muons are a tool to measure the magnetic properties of materials since the precession rate of the spin can be determined from the observation of the positron directions when the muons decay. For a dc beam an ideal µSR flux for surface µ+ should be about 40 kHz/mm2. In this report we show how this flux could be achieved in a beam line using the AGS complex at BNL for a source of protons. We also determined that an orbit feedback system with a pair of thin silicon position monitors and kickers would miss the desired flux by at least an order of magnitude, even with perfect time resolution and no multiple scattering.

  14. First on-line results for As and F beams from HRIBF target/ion sources

    International Nuclear Information System (INIS)

    Carter, H.K.; Kormicki, J.; Stracener, D.W.; Breitenbach, J.B.; Blackmon, J.C.; Smith, M.S.; Bardayan, D.W.

    1996-01-01

    The first on-line tests of the ion sources to provide radioactive ion beams of 69,70 As and 17,18 F for the Holifield Radioactive Ion Beam Facility have been performed using the UNISOR facility at HRIBF. For 70 As the measured efficiency is 0.8 ± 0.3% with a hold-up time of 3.6 ± 0.3 hours as measured with 72 As at a target temperature of 1,270 C. For 17 F the efficiency for Al 17 F is 0.0024 ± 0.0008% with a hold-up time of 16.4 ± 0.8 m as measured with Al 18 F at a target temperature of 1,470 C

  15. Implementation of a Direct Link between the LHC Beam Interlock System and the LHC Beam Dumping System Re-Triggering Lines

    CERN Document Server

    Gabourin, S; Denz, R; Magnin, N; Uythoven, J; Wollmann, D; Zerlauth, M; Vatansever, V; Bartholdt, M; Bertsche, B; Zeiler, P

    2014-01-01

    To avoid damage of accelerator equipment due to impacting beam, the controlled removal of the LHC beams from the collider rings towards the dump blocks must be guaranteed at all times. When a beam dump is demanded, the Beam Interlock System communicates this request to the Trigger Synchronisation and Distribution System of the LHC Beam Dumping System. Both systems were built according to high reliability standards. To further reduce the risk of incapability to dump the beams in case of correlated failures in the Trigger Synchronisation and Distribution System, a new direct link from the Beam Interlock System to the re-triggering lines of the LHC Beam Dumping System will be implemented for the start-up with beam in 2015. The link represents a diverse redundancy to the current implementation, which should neither significantly increase the risk for so-called asynchronous beam dumps nor compromise machine availability. This paper describes the implementation choices of this link. Furthermore the results of a rel...

  16. Absolute x-ray dosimetry on a synchrotron medical beam line with a graphite calorimeter.

    Science.gov (United States)

    Harty, P D; Lye, J E; Ramanathan, G; Butler, D J; Hall, C J; Stevenson, A W; Johnston, P N

    2014-05-01

    The absolute dose rate of the Imaging and Medical Beamline (IMBL) on the Australian Synchrotron was measured with a graphite calorimeter. The calorimetry results were compared to measurements from the existing free-air chamber, to provide a robust determination of the absolute dose in the synchrotron beam and provide confidence in the first implementation of a graphite calorimeter on a synchrotron medical beam line. The graphite calorimeter has a core which rises in temperature when irradiated by the beam. A collimated x-ray beam from the synchrotron with well-defined edges was used to partially irradiate the core. Two filtration sets were used, one corresponding to an average beam energy of about 80 keV, with dose rate about 50 Gy/s, and the second filtration set corresponding to average beam energy of 90 keV, with dose rate about 20 Gy/s. The temperature rise from this beam was measured by a calibrated thermistor embedded in the core which was then converted to absorbed dose to graphite by multiplying the rise in temperature by the specific heat capacity for graphite and the ratio of cross-sectional areas of the core and beam. Conversion of the measured absorbed dose to graphite to absorbed dose to water was achieved using Monte Carlo calculations with the EGSnrc code. The air kerma measurements from the free-air chamber were converted to absorbed dose to water using the AAPM TG-61 protocol. Absolute measurements of the IMBL dose rate were made using the graphite calorimeter and compared to measurements with the free-air chamber. The measurements were at three different depths in graphite and two different filtrations. The calorimetry measurements at depths in graphite show agreement within 1% with free-air chamber measurements, when converted to absorbed dose to water. The calorimetry at the surface and free-air chamber results show agreement of order 3% when converted to absorbed dose to water. The combined standard uncertainty is 3.9%. The good agreement of

  17. Development of highly polished, grazing incidence mirrors for synchrotron radiation beam lines at SSRL

    Energy Technology Data Exchange (ETDEWEB)

    Tirsell, K.G.; Berglin, E.J.; Fuchs, B.A.; Holdener, F.R.; Humpal, H.H.; Karpenko, V.P.; Kulkarni, S.; Fantone, S.D.

    1987-08-01

    New platinum-coated grazing incidence mirrors with low surface roughnesses have been developed to focus bending magnet radiation from the SSRL/SLAC SPEAR storage ring on the entrance slits of two Beam Line VIII grating monochromators. The first mirror in the toroidal grating monochromator (TGM) branch is a cooled SiC cylinder capable of absorbing synchrotron radiation power levels of up to 260 watts without excessive distortion. This mirror deflects the beam vertically through a 12/degree/ angle and focuses it sagitally on the TGM entrance slit plane. The second TGM optical element is a fused-silica spherical mirror with a large radius of curvature that deflects the beam vertically through an additional 12/degree/ and focuses it tangentially with 3/1 demagnification. The first mirror in our spherical grating branch is a 5/degree/-vertically deflecting, cooled SiC toroid designed to focus tangentially on the monochromator entrance slits and sagitally in the exit slits. A 4/degree/-deflecting fused silica mirror is used after the exit sites in each beam line to refocus on to the sample. For this application a thin cylinder is bent to approximate an ellipsoid. The mirrors are now installed at SSRL and performance measurements are planned. Qualitatively the focus of the TGM optics at the entrance slit plane appears very good. In this paper we discuss considerations leading to the choice of SiC for each of the two first mirrors. We present highlights of the development of these mirrors with some emphasis on SiC polishing techniques. In addition, the specialized metrology developed to produce the more difficult figure of the toroid will be described. Measured surface roughness and figure results will be presented. 19 refs., 11 figs.

  18. Development of highly polished, grazing incidence mirrors for synchrotron radiation beam lines at SSRL

    International Nuclear Information System (INIS)

    Tirsell, K.G.; Berglin, E.J.; Fuchs, B.A.; Holdener, F.R.; Humpal, H.H.; Karpenko, V.P.; Kulkarni, S.; Fantone, S.D.

    1987-08-01

    New platinum-coated grazing incidence mirrors with low surface roughnesses have been developed to focus bending magnet radiation from the SSRL/SLAC SPEAR storage ring on the entrance slits of two Beam Line VIII grating monochromators. The first mirror in the toroidal grating monochromator (TGM) branch is a cooled SiC cylinder capable of absorbing synchrotron radiation power levels of up to 260 watts without excessive distortion. This mirror deflects the beam vertically through a 12/degree/ angle and focuses it sagitally on the TGM entrance slit plane. The second TGM optical element is a fused-silica spherical mirror with a large radius of curvature that deflects the beam vertically through an additional 12/degree/ and focuses it tangentially with 3/1 demagnification. The first mirror in our spherical grating branch is a 5/degree/-vertically deflecting, cooled SiC toroid designed to focus tangentially on the monochromator entrance slits and sagitally in the exit slits. A 4/degree/-deflecting fused silica mirror is used after the exit sites in each beam line to refocus on to the sample. For this application a thin cylinder is bent to approximate an ellipsoid. The mirrors are now installed at SSRL and performance measurements are planned. Qualitatively the focus of the TGM optics at the entrance slit plane appears very good. In this paper we discuss considerations leading to the choice of SiC for each of the two first mirrors. We present highlights of the development of these mirrors with some emphasis on SiC polishing techniques. In addition, the specialized metrology developed to produce the more difficult figure of the toroid will be described. Measured surface roughness and figure results will be presented. 19 refs., 11 figs

  19. FLOC: Field Line and Orbit Code for the study of ripple beam injection into tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Fowler, R. H.; Lee, D. K.; Gaffney, P. W.; Rome, J. A.

    1978-06-01

    The computer code described is used to study ripple beam injection into a tokamak plasma. The collisionless guiding center equations of motion are integrated to find the orbits of single particles in realistic magnetic fields for ripple injection. In order to determine if the ripple is detrimental to the plasma, the magnetic flux surfaces are constructed by integration of the field line equations. The numerical techniques are described, and use of the code is outlined. A program listing is provided, and the results of sample cases are presented.

  20. Coulomb field strength measurement by electro-optic spectral decoding system at the CALIFES beam line

    CERN Document Server

    Pan, R; Lefevre, T; Gillepsie, WA; CERN. Geneva. ATS Department

    2016-01-01

    Electro-optic (EO) techniques are increasingly used for longitudinal bunch profile measurements. A bunch profile monitor, based on electro-optic spectral decoding(EOSD), has been developed and demonstrated on the CALIFES beam line at CERN. The EO response is analysed using a frequency domain description, and two methods for extraction of absolute Coulomb field strengths from the electron bunch are demonstrated. Measurements at field strengths up to 1.3 MV/m agree with the expectation based on independent charge measurements.

  1. Design of the beam profile monitor system for the RHIC injection line

    International Nuclear Information System (INIS)

    Witkover, R.L.

    1995-01-01

    A video profile monitor (VPM) system will be used in the AGS-to-RHIC (ATR) transfer line to acquire single bunches transferred at 30 Hz. An array of 12 video cameras will be connected to 4 frame grabbers through a wide-band flux. Fast VME image processing boards will analyze a 120 x 120 subset of the image, generated by a 4 x 4 convolution or an ROI computation and sent over the network during the AGS recycle time. Details of the design, results of lab tests and studies with ion and proton beams will be presented

  2. FLOC: Field Line and Orbit Code for the study of ripple beam injection into tokamaks

    International Nuclear Information System (INIS)

    Fowler, R.H.; Lee, D.K.; Gaffney, P.W.; Rome, J.A.

    1978-06-01

    The computer code described is used to study ripple beam injection into a tokamak plasma. The collisionless guiding center equations of motion are integrated to find the orbits of single particles in realistic magnetic fields for ripple injection. In order to determine if the ripple is detrimental to the plasma, the magnetic flux surfaces are constructed by integration of the field line equations. The numerical techniques are described, and use of the code is outlined. A program listing is provided, and the results of sample cases are presented

  3. 100 years of elementary particles [Beam Line, vol. 27, issue 1, Spring 1997

    Energy Technology Data Exchange (ETDEWEB)

    Pais, Abraham; Weinberg, Steven; Quigg, Chris; Riordan, Michael; Panofsky, Wolfgang K.H.; Trimble, Virginia

    1997-04-01

    This issue of Beam Line commemorates the 100th anniversary of the April 30, 1897 report of the discovery of the electron by J.J. Thomson and the ensuing discovery of other subatomic particles. In the first three articles, theorists Abraham Pais, Steven Weinberg, and Chris Quigg provide their perspectives on the discoveries of elementary particles as well as the implications and future directions resulting from these discoveries. In the following three articles, Michael Riordan, Wolfgang Panofsky, and Virginia Trimble apply our knowledge about elementary particles to high-energy research, electronics technology, and understanding the origin and evolution of our Universe.

  4. 100 years of elementary particles [Beam Line, vol. 27, number 1, Spring 1997

    International Nuclear Information System (INIS)

    Pais, Abraham; Weinberg, Steven; Quigg, Chris; Riordan, Michael; Panofsky, Wolfgang K.H.; Trimble, Virginia

    1997-01-01

    This issue of Beam Line commemorates the 100th anniversary of the April 30, 1897 report of the discovery of the electron by J.J. Thomson and the ensuing discovery of other subatomic particles. In the first three articles, theorists Abraham Pais, Steven Weinberg, and Chris Quigg provide their perspectives on the discoveries of elementary particles as well as the implications and future directions resulting from these discoveries. In the following three articles, Michael Riordan, Wolfgang Panofsky, and Virginia Trimble apply our knowledge about elementary particles to high-energy research, electronics technology, and understanding the origin and evolution of our Universe

  5. Generating AN Optimum Treatment Plan for External Beam Radiation Therapy.

    Science.gov (United States)

    Kabus, Irwin

    1990-01-01

    The application of linear programming to the generation of an optimum external beam radiation treatment plan is investigated. MPSX, an IBM linear programming software package was used. All data originated from the CAT scan of an actual patient who was treated for a pancreatic malignant tumor before this study began. An examination of several alternatives for representing the cross section of the patient showed that it was sufficient to use a set of strategically placed points in the vital organs and tumor and a grid of points spaced about one half inch apart for the healthy tissue. Optimum treatment plans were generated from objective functions representing various treatment philosophies. The optimum plans were based on allowing for 216 external radiation beams which accounted for wedges of any size. A beam reduction scheme then reduced the number of beams in the optimum plan to a number of beams small enough for implementation. Regardless of the objective function, the linear programming treatment plan preserved about 95% of the patient's right kidney vs. 59% for the plan the hospital actually administered to the patient. The clinician, on the case, found most of the linear programming treatment plans to be superior to the hospital plan. An investigation was made, using parametric linear programming, concerning any possible benefits derived from generating treatment plans based on objective functions made up of convex combinations of two objective functions, however, this proved to have only limited value. This study also found, through dual variable analysis, that there was no benefit gained from relaxing some of the constraints on the healthy regions of the anatomy. This conclusion was supported by the clinician. Finally several schemes were found that, under certain conditions, can further reduce the number of beams in the final linear programming treatment plan.

  6. Characteristic analysis of coupled transmission lines in stripline-type beam position monitor

    International Nuclear Information System (INIS)

    Suwada, T.

    2013-01-01

    Signal transmission characteristics in stripline electrodes of a stripline-type beam position monitor (BPM) are discussed on the basis of a coupled-mode analysis in electromagnetically coupled transmission lines. The physical prospect in the calibration procedure of stripline electrodes is improved in terms of signal transmission characteristics in the frequency domain. It is demonstrated that in the signal transmission with electromagnetic coupling between the stripline electrodes, the magnetic- and electric-coupling parameters play an important role depending upon the spatial configuration and mechanical structure of the stripline electrodes. In this report, a theoretical analysis, and experimental investigation into signal transmission characteristics and performance in a standard stripline-type BPM are described in detail on the basis of a coupled-mode analysis in uniform transmission lines

  7. Design and construction of UVSOR-BL4A2 beam line for nano-structure processing

    CERN Document Server

    Takezoe, N; Tanaka, T; Kurosawa, K; Nonogaki, Y; Noda, H; Mekaru, H; Urisu, T

    2001-01-01

    We have designed and constructed a new beam line BL4A2 at UVSOR mainly for nano-structure fabrication based on synchrotron radiation stimulated surface photochemical reactions. In order to obtain high-photon flux, we use white ray beam focused with only one mirror. The beam line is connected with ultra-high vacuum scanning tunneling microscope for in-situ atomic scale observations, low energy electron diffraction and Auger electron spectroscope for surface crystal structure characterization, and photo-stimulated surface reaction chamber. In order to monitor the optical properties with atomic scale, a near field optical microscope is planned to be installed.

  8. Design and construction of UVSOR-BL4A2 beam line for nano-structure processing

    International Nuclear Information System (INIS)

    Takezoe, N.; Yanagida, H.; Tanaka, T.; Kurosawa, K.; Nonogaki, Y.; Noda, H.; Mekaru, H.; Urisu, T.

    2001-01-01

    We have designed and constructed a new beam line BL4A2 at UVSOR mainly for nano-structure fabrication based on synchrotron radiation stimulated surface photochemical reactions. In order to obtain high-photon flux, we use white ray beam focused with only one mirror. The beam line is connected with ultra-high vacuum scanning tunneling microscope for in-situ atomic scale observations, low energy electron diffraction and Auger electron spectroscope for surface crystal structure characterization, and photo-stimulated surface reaction chamber. In order to monitor the optical properties with atomic scale, a near field optical microscope is planned to be installed

  9. SU-D-BRC-01: An Automatic Beam Model Commissioning Method for Monte Carlo Simulations in Pencil-Beam Scanning Proton Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Qin, N; Shen, C; Tian, Z; Jiang, S; Jia, X [UT Southwestern Medical Ctr, Dallas, TX (United States)

    2016-06-15

    Purpose: Monte Carlo (MC) simulation is typically regarded as the most accurate dose calculation method for proton therapy. Yet for real clinical cases, the overall accuracy also depends on that of the MC beam model. Commissioning a beam model to faithfully represent a real beam requires finely tuning a set of model parameters, which could be tedious given the large number of pencil beams to commmission. This abstract reports an automatic beam-model commissioning method for pencil-beam scanning proton therapy via an optimization approach. Methods: We modeled a real pencil beam with energy and spatial spread following Gaussian distributions. Mean energy, and energy and spatial spread are model parameters. To commission against a real beam, we first performed MC simulations to calculate dose distributions of a set of ideal (monoenergetic, zero-size) pencil beams. Dose distribution for a real pencil beam is hence linear superposition of doses for those ideal pencil beams with weights in the Gaussian form. We formulated the commissioning task as an optimization problem, such that the calculated central axis depth dose and lateral profiles at several depths match corresponding measurements. An iterative algorithm combining conjugate gradient method and parameter fitting was employed to solve the optimization problem. We validated our method in simulation studies. Results: We calculated dose distributions for three real pencil beams with nominal energies 83, 147 and 199 MeV using realistic beam parameters. These data were regarded as measurements and used for commission. After commissioning, average difference in energy and beam spread between determined values and ground truth were 4.6% and 0.2%. With the commissioned model, we recomputed dose. Mean dose differences from measurements were 0.64%, 0.20% and 0.25%. Conclusion: The developed automatic MC beam-model commissioning method for pencil-beam scanning proton therapy can determine beam model parameters with

  10. Quantitative evaluation of potential irradiation geometries for carbon-ion beam grid therapy.

    Science.gov (United States)

    Tsubouchi, Toshiro; Henry, Thomas; Ureba, Ana; Valdman, Alexander; Bassler, Niels; Siegbahn, Albert

    2018-03-01

    Radiotherapy using grids containing cm-wide beam elements has been carried out sporadically for more than a century. During the past two decades, preclinical research on radiotherapy with grids containing small beam elements, 25 μm-0.7 mm wide, has been performed. Grid therapy with larger beam elements is technically easier to implement, but the normal tissue tolerance to the treatment is decreasing. In this work, a new approach in grid therapy, based on irradiations with grids containing narrow carbon-ion beam elements was evaluated dosimetrically. The aim formulated for the suggested treatment was to obtain a uniform target dose combined with well-defined grids in the irradiated normal tissue. The gain, obtained by crossfiring the carbon-ion beam grids over a simulated target volume, was quantitatively evaluated. The dose distributions produced by narrow rectangular carbon-ion beams in a water phantom were simulated with the PHITS Monte Carlo code. The beam-element height was set to 2.0 cm in the simulations, while the widths varied from 0.5 to 10.0 mm. A spread-out Bragg peak (SOBP) was then created for each beam element in the grid, to cover the target volume with dose in the depth direction. The dose distributions produced by the beam-grid irradiations were thereafter constructed by adding the dose profiles simulated for single beam elements. The variation of the valley-to-peak dose ratio (VPDR) with depth in water was thereafter evaluated. The separation of the beam elements inside the grids were determined for different irradiation geometries with a selection criterion. The simulated carbon-ion beams remained narrow down to the depths of the Bragg peaks. With the formulated selection criterion, a beam-element separation which was close to the beam-element width was found optimal for grids containing 3.0-mm-wide beam elements, while a separation which was considerably larger than the beam-element width was found advantageous for grids containing 0.5-mm

  11. Doppler-shift spectra of Hα lines from negative-ion-based neutral beams for large helical device neutral beam injection

    International Nuclear Information System (INIS)

    Oka, Y.; Ikeda, K.; Takeiri, Y.; Tsumori, K.; Kaneko, O.; Nagaoka, K.; Osakabe, M.; Asano, E.; Kondo, T.; Sato, M.; Shibuya, M.; Grisham, L.; Umeda, N.; Honda, A.; Ikeda, Y.; Yamamoto, T.

    2006-01-01

    The velocity spectra of the negative-ion-(H - ) based neutral beams are studied in high-performance large-area ion sources during injection into large helical device fusion plasmas. We are conducting systematic observations in standard neutral beam injection to correlate beam spectra with source operating conditions. Almost all of the transmitted beam power was at full acceleration energy (∼170 keV). The small stripping beam component which was produced in the extraction gap was evaluated to be about 9%-22% by amplitude of the measured spectra for the sources in beam lines 1 and 2. H - production uniformity from the spectrum profile was 86%-90% for three sources. For the longest pulse injection during 74 and 128 s, a full energy component tended to decrease with time, while the accelerator gap stripping tail tended to increase slightly with time, which is attributed to beam-induced outgassing in the accelerator. A higher conductance multislot ground grid accelerator appeared to show little growth in the accelerator gap beam stripping during long pulses compared to the conventional multiaperture ground grid. The beam uniformity appeared to vary in part with the Cs uniformity on the plasma grid

  12. Real-time beam monitoring in scanned proton therapy

    Science.gov (United States)

    Klimpki, G.; Eichin, M.; Bula, C.; Rechsteiner, U.; Psoroulas, S.; Weber, D. C.; Lomax, A.; Meer, D.

    2018-05-01

    When treating cancerous tissues with protons beams, many centers make use of a step-and-shoot irradiation technique, in which the beam is steered to discrete grid points in the tumor volume. For safety reasons, the irradiation is supervised by an independent monitoring system validating cyclically that the correct amount of protons has been delivered to the correct position in the patient. Whenever unacceptable inaccuracies are detected, the irradiation can be interrupted to reinforce a high degree of radiation protection. At the Paul Scherrer Institute, we plan to irradiate tumors continuously. By giving up the idea of discrete grid points, we aim to be faster and more flexible in the irradiation. But the increase in speed and dynamics necessitates a highly responsive monitoring system to guarantee the same level of patient safety as for conventional step-and-shoot irradiations. Hence, we developed and implemented real-time monitoring of the proton beam current and position. As such, we read out diagnostic devices with 100 kHz and compare their signals against safety tolerances in an FPGA. In this paper, we report on necessary software and firmware enhancements of our control system and test their functionality based on three exemplary error scenarios. We demonstrate successful implementation of real-time beam monitoring and, consequently, compliance with international patient safety regulations.

  13. Moving beam irradiation in combined therapy of cervix uteri cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, O M; Zholkiver, K I

    1976-07-01

    Postoperative moving beam irradiation in a dose of 3900 to 365 rad was conducted in 98 patients with the I--II stages of cervix uteri cancer. Skin reactions to irradiation were absent, marked leukopenia developed in 4 patients. Of 39 patients followed up for more than 5 years 35 have lived without relapses and metastases.

  14. T2-weighted endorectal magnetic resonance imaging of prostate cancer after external beam radiation therapy

    International Nuclear Information System (INIS)

    Westphalen, Antonio C.; Kurhanewicz, John; Cunha, Rui M.G.; Hsu, I-Chow; Kornak, John; Zhao, Shoujun; Coakley, Fergus V.

    2009-01-01

    Purpose: To retrospectively determine the accuracy of T2-weighted endorectal MR imaging in the detection of prostate cancer after external beam radiation therapy and to investigate the relationship between imaging accuracy and time since therapy. Materials and Methods: Institutional review board approval was obtained and the study was HIPPA compliant. We identified 59 patients who underwent 1.5 Tesla endorectal MR imaging of the prostate between 1999 and 2006 after definitive external beam radiation therapy for biopsy-proven prostate cancer. Two readers recorded the presence or absence of tumor on T2-weighted images. Logistic regression and Fisher's exact tests for 2x2 tables were used to determine the accuracy of imaging and investigate if accuracy differed between those imaged within 3 years of therapy (n = 25) and those imaged more than 3 years after therapy (n = 34). Transrectal biopsy was used as the standard of reference for the presence or absence of recurrent cancer. Results: Thirty-four of 59 patients (58%) had recurrent prostate cancer detected on biopsy. The overall accuracy of T2-weighted MR imaging in the detection cancer after external beam radiation therapy was 63% (37/59) for reader 1 and 71% for reader 2 (42/59). For both readers, logistic regression showed no difference in accuracy between those imaged within 3 years of therapy and those imaged more than 3 years after therapy (p = 0.86 for reader 1 and 0.44 for reader 2). Conclusion: T2-weighted endorectal MR imaging has low accuracy in the detection of prostate cancer after external beam radiation therapy, irrespective of the time since therapy. (author)

  15. Measurement of secondary particle production induced by particle therapy ion beams impinging on a PMMA target

    Directory of Open Access Journals (Sweden)

    Toppi M.

    2016-01-01

    Full Text Available Particle therapy is a technique that uses accelerated charged ions for cancer treatment and combines a high irradiation precision with a high biological effectiveness in killing tumor cells [1]. Informations about the secondary particles emitted in the interaction of an ion beam with the patient during a treatment can be of great interest in order to monitor the dose deposition. For this purpose an experiment at the HIT (Heidelberg Ion-Beam Therapy Center beam facility has been performed in order to measure fluxes and emission profiles of secondary particles produced in the interaction of therapeutic beams with a PMMA target. In this contribution some preliminary results about the emission profiles and the energy spectra of the detected secondaries will be presented.

  16. Design of the extraction arc for the 2nd beam line of the free-electron laser FLASH

    International Nuclear Information System (INIS)

    Scholz, Matthias

    2014-01-01

    In this thesis, I deal with the design of the extraction arc for the second beam line of FLASH, an FEL (Free-Electron Laser) user facility at DESY Hamburg. Both beam lines will use the same linear accelerator and their separation will take place behind the last accelerating module. I present the constraints for the extraction arc given by the beam line layout of the existing machine, by the building environment of the new beam line and in particular, by coherent synchrotron radiation (CSR). The impact from CSR is presented, and I show how to mitigate these effects and what that means for the beam line design. The optimization of the extraction arc was done applying the downhill simplex algorithm which is presented, first in its basic form to explain the operation principle and then in a more advanced version as used in the applied program. I introduce in this thesis the final layout of the extraction arc including the following matching section. This layout fulfills all given constraints and can provide the required electron beam quality for FEL operation. In order to prove this, I present start-to-end simulations for different bunch charges and for two different wavelengths.

  17. Proton therapy posterior beam approach with pencil beam scanning for esophageal cancer. Clinical outcome, dosimetry, and feasibility

    Energy Technology Data Exchange (ETDEWEB)

    Zeng, Yue-Can [Shengjing Hospital of China Medical University, Department of Medical Oncology, Cancer Center, Shenyang (China); University of Washington Medical Center, Department of Radiation Oncology, 1959 NE Pacific Street, Campus Box 356043, Seattle, WA (United States); Vyas, Shilpa; Apisarnthanarax, Smith; Zeng, Jing [University of Washington Medical Center, Department of Radiation Oncology, 1959 NE Pacific Street, Campus Box 356043, Seattle, WA (United States); Dang, Quang; Schultz, Lindsay [Seattle Cancer Care Alliance Proton Therapy Center, Seattle, WA (United States); Bowen, Stephen R. [University of Washington Medical Center, Department of Radiation Oncology, 1959 NE Pacific Street, Campus Box 356043, Seattle, WA (United States); University of Washington Medical Center, Department of Radiology, Seattle, WA (United States); Shankaran, Veena [University of Washington Medical Center, Department of Medical Oncology, Seattle, WA (United States); Farjah, Farhood [University of Washington Medical Center, Department of Surgery, Division of Cardiothoracic Surgery, Seattle, WA (United States); University of Washington Medical Center, Department of Surgery, Surgical Outcomes Research Center, Seattle, WA (United States); Oelschlager, Brant K. [University of Washington Medical Center, Department of Surgery, Seattle, WA (United States)

    2016-12-15

    The aim of this study is to present the dosimetry, feasibility, and preliminary clinical results of a novel pencil beam scanning (PBS) posterior beam technique of proton treatment for esophageal cancer in the setting of trimodality therapy. From February 2014 to June 2015, 13 patients with locally advanced esophageal cancer (T3-4N0-2M0; 11 adenocarcinoma, 2 squamous cell carcinoma) were treated with trimodality therapy (neoadjuvant chemoradiation followed by esophagectomy). Eight patients were treated with uniform scanning (US) and 5 patients were treated with a single posterior-anterior (PA) beam PBS technique with volumetric rescanning for motion mitigation. Comparison planning with PBS was performed using three plans: AP/PA beam arrangement; PA plus left posterior oblique (LPO) beams, and a single PA beam. Patient outcomes, including pathologic response and toxicity, were evaluated. All 13 patients completed chemoradiation to 50.4 Gy (relative biological effectiveness, RBE) and 12 patients underwent surgery. All 12 surgical patients had an R0 resection and pathologic complete response was seen in 25 %. Compared with AP/PA plans, PA plans have a lower mean heart (14.10 vs. 24.49 Gy, P < 0.01), mean stomach (22.95 vs. 31.33 Gy, P = 0.038), and mean liver dose (3.79 vs. 5.75 Gy, P = 0.004). Compared to the PA/LPO plan, the PA plan reduced the lung dose: mean lung dose (4.96 vs. 7.15 Gy, P = 0.020) and percentage volume of lung receiving 20 Gy (V{sub 20}; 10 vs. 17 %, P < 0.01). Proton therapy with a single PA beam PBS technique for preoperative treatment of esophageal cancer appears safe and feasible. (orig.) [German] Wir stellen die Vergleichsdosimetrie, Realisierbarkeit und die vorlaeufigen klinischen Ergebnisse einer neuen Pencil-Beam-Scanning(-PBS)/Posterior-Beam-Methode innerhalb der Protonentherapie fuer Speiseroehrenkrebs im Setting einer trimodalen Therapie vor. Von Februar 2014 bis Juni 2015 erhielten 13 Patienten mit lokal fortgeschrittenem

  18. Superconducting magnet system for the J-PARC neutrino beam line. Development, construction and operation of superconducting magnets

    International Nuclear Information System (INIS)

    Sasaki, Ken-ichi; Nakamoto, Tatsushi; Ajima, Yasuo; Okamura, Takahiro; Ogitsu, Toru; Kimura, Nobuhiro; Terashima, Akio; Tomaru, Takayuki; Higashi, Norio

    2010-01-01

    Superconducting combined-function magnets have been utilized for the 50-GeV, 750-kW proton beam line in the J-PARC neutrino experiment. The magnets are designed to provide a dipole field of 2.6 T combined with a quadrupole field of 19 T/m in a coil aperture of 173.4 mm at a nominal current of 7,345 A. Following the success of a prototype R and D project, a superconducting magnet system for the J-PARC neutrino beam line has been constructed since 2005. Using a new conceptual beam line with the superconducting combined-function magnets has demonstrated successful beam transport to the target neutrino production. (author)

  19. A 4 MV flattening filter-free beam: commissioning and application to conformal therapy and volumetric modulated arc therapy

    International Nuclear Information System (INIS)

    Stevens, S W; Rosser, K E; Bedford, J L

    2011-01-01

    Recent studies have indicated that radiotherapy treatments undertaken on a flattening filter-free (FFF) linear accelerator have a number of advantages over treatments undertaken on a conventional linear accelerator. In addition, 4 MV photon beams may give improved isodose coverage for some treatment volumes at air/tissue interfaces, compared to when utilizing the clinical standard of 6 MV photons. In order to investigate these benefits, FFF beams were established on an Elekta Beam Modulator linear accelerator for 4 MV photons. Commissioning beam data were obtained for open and wedged fields. The measured data were then imported into a treatment planning system and a beam model was commissioned. The beam model was optimized to improve dose calculations at shallow, clinically relevant depths. Following verification, the beam model was utilized in a treatment planning study, including volumetric modulated arc therapy, for a selection of lung, breast/chest wall and larynx patients. Increased dose rates of around 800 MU min -1 were recorded for open fields (relative to 320 MU min -1 for filtered open fields) and reduced head scatter was inferred from output factor measurements. Good agreement between planned and delivered dose was observed in verification of treatment plans. The planning study indicated that with a FFF beam, equivalent (and in some cases improved) isodose profiles could be achieved for small lung and larynx treatment volumes relative to 4 MV filtered treatments. Furthermore, FFF treatments with wedges could be replicated using open fields together with an 'effective wedge' technique and isocentre shift. Clinical feasibility of a FFF beam was therefore demonstrated, with beam modelling, treatment planning and verification being successfully accomplished.

  20. Beam-centric algorithm for pretreatment patient position correction in external beam radiation therapy

    International Nuclear Information System (INIS)

    Bose, Supratik; Shukla, Himanshu; Maltz, Jonathan

    2010-01-01

    Purpose: In current image guided pretreatment patient position adjustment methods, image registration is used to determine alignment parameters. Since most positioning hardware lacks the full six degrees of freedom (DOF), accuracy is compromised. The authors show that such compromises are often unnecessary when one models the planned treatment beams as part of the adjustment calculation process. The authors present a flexible algorithm for determining optimal realizable adjustments for both step-and-shoot and arc delivery methods. Methods: The beam shape model is based on the polygonal intersection of each beam segment with the plane in pretreatment image volume that passes through machine isocenter perpendicular to the central axis of the beam. Under a virtual six-DOF correction, ideal positions of these polygon vertices are computed. The proposed method determines the couch, gantry, and collimator adjustments that minimize the total mismatch of all vertices over all segments with respect to their ideal positions. Using this geometric error metric as a function of the number of available DOF, the user may select the most desirable correction regime. Results: For a simulated treatment plan consisting of three equally weighted coplanar fixed beams, the authors achieve a 7% residual geometric error (with respect to the ideal correction, considered 0% error) by applying gantry rotation as well as translation and isocentric rotation of the couch. For a clinical head-and-neck intensity modulated radiotherapy plan with seven beams and five segments per beam, the corresponding error is 6%. Correction involving only couch translation (typical clinical practice) leads to a much larger 18% mismatch. Clinically significant consequences of more accurate adjustment are apparent in the dose volume histograms of target and critical structures. Conclusions: The algorithm achieves improvements in delivery accuracy using standard delivery hardware without significantly increasing

  1. Production of chemically reactive radioactive ion beams through on-line separation

    International Nuclear Information System (INIS)

    Joinet, A.

    2003-10-01

    The ISOL (isotope separation on line) allows the production of secondary radioactive ion beams through spallation or fragmentation or fission reactions that take place in a thick target bombarded by a high intensity primary beam. The challenge is to increase the intensity and purity of the radioactive beam. The optimization of the system target/source requires the right choice of material for the target by taking into account the stability of the material, its reactivity and the ionization method used. The target is an essential part of the system because radioactive elements are generated in it and are released more or less quickly. Tests have been made in order to select the best fitted material for the release of S, Se, Te, Ge and Sn. Materials tested as target filling are: ZrO 2 , Nb, Ti, V,TiO 2 , CeO x , ThO 2 , C, ZrC 4 and VC). Other molecules such as: COSe, COS, SeS, COTe, GeS, SiS, SnS have been studied to ease the extraction of recoil nuclei (Se, S, Te, Ge and Sn) produced inside the target

  2. Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions

    International Nuclear Information System (INIS)

    Berman, Abigail T.; James, Sara St.; Rengan, Ramesh

    2015-01-01

    Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT), through its characteristic Bragg peak, has the potential to decrease the toxicity of radiotherapy, and, subsequently improve the therapeutic ratio. Herein, we provide a primer on the physics of proton beam therapy for lung cancer, present the existing data in early-stage and locally-advanced non-small cell lung cancer (NSCLC), as well as in special situations such as re-irradiation and post-operative radiation therapy. We then present the technical challenges, such as anatomic changes and motion management, and future directions for PBT in lung cancer, including pencil beam scanning

  3. Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions

    Directory of Open Access Journals (Sweden)

    Abigail T. Berman

    2015-07-01

    Full Text Available Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT, through its characteristic Bragg peak, has the potential to decrease the toxicity of radiotherapy, and, subsequently improve the therapeutic ratio. Herein, we provide a primer on the physics of proton beam therapy for lung cancer, present the existing data in early-stage and locally-advanced non-small cell lung cancer (NSCLC, as well as in special situations such as re-irradiation and post-operative radiation therapy. We then present the technical challenges, such as anatomic changes and motion management, and future directions for PBT in lung cancer, including pencil beam scanning.

  4. Experience with high-energy electron beam therapy at the University of Chicago

    International Nuclear Information System (INIS)

    Griem, M.L.; Kuchnir, F.T.; Lanzl, L.H.; Skaggs, L.S.; Sutton, H.G.; Tokars, R.

    1979-01-01

    Current utilization of the linear accelerator as well as 5-year cumulative experience in radiotherapy is presented. Cutaneous lymphomas and mammary gland carcinomas were the prime experience region; however, cancers at other locations were treated with mixed-beam therapy; employing fast neutrons and photon beams. The technique appears promising for abdominal tumors and deep-seated malignancies. Carcinoma of the pancreas responds favorably to this technique

  5. Application of magnetically insulated transmission lines for high current, high voltage electron beam accelerators

    International Nuclear Information System (INIS)

    Shope, S.L.; Mazarakis, M.G.; Frost, C.A.; Poukey, J.W.; Turman, B.N.

    1993-01-01

    Self Magnetically Insulated Transmission Lines (MITL) adders have been used successfully in a number of Sandia accelerators such as HELIA, HERMES III, and SABRE. Most recently the authors used a MITL adder in the RADLAC/SMILE electron beam accelerator to produce high quality, small radius (r b < 2 cm), 11 to 15 MeV, 50 to 100-kA beams with a small transverse velocity v perpendicular/c = β perpendicular ≤ 0.1. In RADLAC/SMILE, a coaxial MITL passed through the eight, 2 MV vacuum envelopes. The MITL summed the voltages of all eight feeds to a single foilless diode. The experimental results are in good agreement with code simulations. The authors' success with the MITL technology led them to investigate the application to higher energy accelerator designs. They have a conceptual design for a cavity-fed MITL that sums the voltages from 100 identical, inductively-isolated cavities. Each cavity is a toroidal structure that is driven simultaneously by four 8-ohm pulse-forming lines, providing a 1-MV voltage pulse to each of the 100 cavities. The point design accelerator is 100 MV, 500 kA, with a 30-50-ns FWHM output pulse

  6. Electron beam effects on the spectroscopy of satellite lines in aluminum X-pinch experiments

    International Nuclear Information System (INIS)

    Abdallah, J. Jr.; Csanak, G.; Clark, R.E.H.; Faenov, A.Ya.; Hammer, D.A.; Pikuz, S.A.; Romanova, P.N.; Shelkovenko, T.A.

    1996-01-01

    Aluminum wire X-pinch experiments performed at the Cornell University XP pulsed power generator and at the Lebedev Institute BIN generator show detailed high resolution spectra for satellite lines of Li-like, Be-like, B-like, and C-like ions. These lines, which correspond to transitions originating from autoionizing levels, are observed in the direction of the anode with respect to the bright X-pinch cross point. The intensities of these satellites are much smaller or absent in the direction of the cathode. Such transitions are caused by collisions of ions with energetic electrons (5-15 keV) which are created by the inductive voltage drop between the cross point and the anode. A collisional-radiative model was constructed using a non-Maxwellian electron energy distribution consisting of a thermal Maxwellian part plus a Gaussian part to represent the high energy electron beam. The shapes of the observed satellite structures are consistent with the calculated spectrum for electron temperatures between 30-100 eV, and beam densities of about 10 -7 times the plasma electron density. (author). 3 figs., 7 refs

  7. Application of Magnetically Insulated Transmission Lines for high current, high voltage electron beam accelerators

    International Nuclear Information System (INIS)

    Shope, S.L.; Mazarakis, M.G.; Frost, C.A.; Poukey, J.W.; Turman, B.N.

    1991-01-01

    Self Magnetically Insulated Transmission Lines (MITL) adders have been used successfully in a number of Sandia accelerators such as HELIA, HERMES III, and SABRE. Most recently we used at MITL adder in the RADLAC/SMILE electron beam accelerator to produce high quality, small radius (r ρ < 2 cm), 11 to 15 MeV, 50 to 100-kA beams with a small transverse velocity v perpendicular/c = β perpendicular ≤ 0.1. In RADLAC/SMILE, a coaxial MITL passed through the eight, 2 MV vacuum envelopes. The MITL summed the voltages of all eight feeds to a single foilless diode. The experimental results are in good agreement with code simulations. Our success with the MITL technology led us to investigate the application to higher energy accelerator designs. We have a conceptual design for a cavity-fed MITL that sums the voltages from 100 identical, inductively-isolated cavities. Each cavity is a toroidal structure that is driven simultaneously by four 8-ohm pulse-forming lines, providing a 1-MV voltage pulse to each of the 100 cavities. The point design accelerator is 100 MV, 500 kA, with a 30--50 ns FWHM output pulse. 10 refs

  8. Application of magnetically insulated transmission lines for high current, high voltage electron beam accelerators

    Science.gov (United States)

    Shope, S. L.; Mazarakis, M. G.; Frost, C. A.; Poukey, J. W.; Turman, B. N.

    Self Magnetically Insulated Transmission Lines (MITL) adders were used successfully in a number of Sandia accelerators such as HELIA, HERMES III, and SABRE. Most recently we used at MITL adder in the RADLAC/SMILE electron beam accelerator to produce high quality, small radius (r(sub rho) less than 2 cm), 11 - 15 MeV, 50 - 100-kA beams with a small transverse velocity v(perpendicular)/c = beta(perpendicular) less than or equal to 0.1. In RADLAC/SMILE, a coaxial MITL passed through the eight, 2 MV vacuum envelopes. The MITL summed the voltages of all eight feeds to a single foilless diode. The experimental results are in good agreement with code simulations. Our success with the MITL technology led us to investigate the application to higher energy accelerator designs. We have a conceptual design for a cavity-fed MITL that sums the voltages from 100 identical, inductively-isolated cavities. Each cavity is a toroidal structure that is driven simultaneously by four 8-ohm pulse-forming lines, providing a 1-MV voltage pulse to each of the 100 cavities. The point design accelerator is 100 MV, 500 kA, with a 30 - 50 ns FWHM output pulse.

  9. Electron beam effects on the spectroscopy of satellite lines in aluminum X-pinch experiments

    Energy Technology Data Exchange (ETDEWEB)

    Abdallah, J Jr; Csanak, G; Clark, R E.H. [Los Alamos National Laboratory, NM (United States); Faenov, A Ya [VNIIFTRI, Mendeleevo (Russian Federation); Hammer, D A [Cornell Univ., Ithaca, NY (United States); Pikuz, S A; Romanova, P N; Shelkovenko, T A [P.N. Lebedev Physical Inst., Moscow (Russian Federation)

    1997-12-31

    Aluminum wire X-pinch experiments performed at the Cornell University XP pulsed power generator and at the Lebedev Institute BIN generator show detailed high resolution spectra for satellite lines of Li-like, Be-like, B-like, and C-like ions. These lines, which correspond to transitions originating from autoionizing levels, are observed in the direction of the anode with respect to the bright X-pinch cross point. The intensities of these satellites are much smaller or absent in the direction of the cathode. Such transitions are caused by collisions of ions with energetic electrons (5-15 keV) which are created by the inductive voltage drop between the cross point and the anode. A collisional-radiative model was constructed using a non-Maxwellian electron energy distribution consisting of a thermal Maxwellian part plus a Gaussian part to represent the high energy electron beam. The shapes of the observed satellite structures are consistent with the calculated spectrum for electron temperatures between 30-100 eV, and beam densities of about 10{sup -7} times the plasma electron density. (author). 3 figs., 7 refs.

  10. ‘Survival’: a simulation toolkit introducing a modular approach for radiobiological evaluations in ion beam therapy

    Science.gov (United States)

    Manganaro, L.; Russo, G.; Bourhaleb, F.; Fausti, F.; Giordanengo, S.; Monaco, V.; Sacchi, R.; Vignati, A.; Cirio, R.; Attili, A.

    2018-04-01

    One major rationale for the application of heavy ion beams in tumour therapy is their increased relative biological effectiveness (RBE). The complex dependencies of the RBE on dose, biological endpoint, position in the field etc require the use of biophysical models in treatment planning and clinical analysis. This study aims to introduce a new software, named ‘Survival’, to facilitate the radiobiological computations needed in ion therapy. The simulation toolkit was written in C++ and it was developed with a modular architecture in order to easily incorporate different radiobiological models. The following models were successfully implemented: the local effect model (LEM, version I, II and III) and variants of the microdosimetric-kinetic model (MKM). Different numerical evaluation approaches were also implemented: Monte Carlo (MC) numerical methods and a set of faster analytical approximations. Among the possible applications, the toolkit was used to reproduce the RBE versus LET for different ions (proton, He, C, O, Ne) and different cell lines (CHO, HSG). Intercomparison between different models (LEM and MKM) and computational approaches (MC and fast approximations) were performed. The developed software could represent an important tool for the evaluation of the biological effectiveness of charged particles in ion beam therapy, in particular when coupled with treatment simulations. Its modular architecture facilitates benchmarking and inter-comparison between different models and evaluation approaches. The code is open source (GPL2 license) and available at https://github.com/batuff/Survival.

  11. GPU-based fast pencil beam algorithm for proton therapy

    International Nuclear Information System (INIS)

    Fujimoto, Rintaro; Nagamine, Yoshihiko; Kurihara, Tsuneya

    2011-01-01

    Performance of a treatment planning system is an essential factor in making sophisticated plans. The dose calculation is a major time-consuming process in planning operations. The standard algorithm for proton dose calculations is the pencil beam algorithm which produces relatively accurate results, but is time consuming. In order to shorten the computational time, we have developed a GPU (graphics processing unit)-based pencil beam algorithm. We have implemented this algorithm and calculated dose distributions in the case of a water phantom. The results were compared to those obtained by a traditional method with respect to the computational time and discrepancy between the two methods. The new algorithm shows 5-20 times faster performance using the NVIDIA GeForce GTX 480 card in comparison with the Intel Core-i7 920 processor. The maximum discrepancy of the dose distribution is within 0.2%. Our results show that GPUs are effective for proton dose calculations.

  12. Relative and absolute dosimetry of proton therapy beams

    International Nuclear Information System (INIS)

    Mazal, A.; Delacroix, S.; Bridier, A.; Daures, J.; Dolo, J.M.; Nauraye, C.; Ferrand, R.; Cosgrave, V.; Habrand, J.L.

    1995-01-01

    Different codes of practice are in use or under preparation by several groups and national or international societies, concerning the dosimetry of proton beams. In spite of a large number of experiences and the increasing interest on this field, there are still large incertitudes on some of the basic conversion and correction factors to get dose values from different measuring methods. In practice, dose uniformity between centers is searched and encouraged by intercomparisons using standard procedures. We present the characteristics and the results on proton dosimetry intercomparisons using calorimeters, Faraday cups and ion chambers, as well as on the use of other detectors like diodes, radiographic films and TLD. New detectors like diamond, scintillators, radiochromic films, alanine, gels, ... can give new solutions to particular problems, provided their response is not affected at the end of the proton range (higher LET region), and their resolution, range, linearity, cost, ... are well adapted to practical situations. Some examples of special challenges are non interfering measurements during treatments for quality control, in vivo measurements, small beams for stereotactic irradiations, scanned beams and correlations between dosimetry, microdosimetry and radiobiology

  13. Condition of the centers of linkage of serum albumin in cancer gynecological patients at beam therapy

    International Nuclear Information System (INIS)

    Malenchenko, A.F.; Belyakovskij, V.N.; Lukovskaya, N.D.; Prigozhaya, T.I.; Stasenkova, S.V.

    2009-01-01

    With the use of the method of fluorescent probes the condition of the centers of linkage of serum albumin in healthy women and in the cancer patients, passing a course of beam therapy, is analyzed at different modes. It is shown that general concentration of albumin in healthy persons and cancer patients are in the limits of normal values, however parameters of effective concentration of albumin, reserve of albumin linkage and toxicity index of patients statistically, for certain, differ in comparison with those in the control group. Carrying out the beam therapy course both split and not split promotes an increase of values of toxicity index. (authors)

  14. The potential of proton beam radiation therapy in lung cancer (including mesothelioma)

    Energy Technology Data Exchange (ETDEWEB)

    Bjelkengren, Goeran [Univ. Hospital, Malmoe (Sweden). Dept. of Oncology; Glimelius, Bengt [Karolinska Inst., Stockholm (Sweden). Dept. of Oncology and Pathology; Akademiska sjukhuset, Uppsala (Sweden). Dept. of Oncology, Radiology and Clinical Immunology

    2005-12-01

    A Swedish group of oncologists and hospital physicists have estimated the number of patients in Sweden suitable for proton beam therapy. The estimations have been based on current statistics of tumour incidence, number of patients potentially eligible for radiation treatment, scientific support from clinical trials and model dose planning studies and knowledge of the dose-response relations of different tumours and normal tissues. It is estimated that about 350 patients with lung cancer and about 20 patients with mesothelioma annually may benefit from proton beam therapy.

  15. Improved Beam Angle Arrangement in Intensity Modulated Proton Therapy Treatment Planning for Localized Prostate Cancer

    International Nuclear Information System (INIS)

    Cao, Wenhua; Lim, Gino J.; Li, Yupeng; Zhu, X. Ronald; Zhang, Xiaodong

    2015-01-01

    Purpose: This study investigates potential gains of an improved beam angle arrangement compared to a conventional fixed gantry setup in intensity modulated proton therapy (IMPT) treatment for localized prostate cancer patients based on a proof of principle study. Materials and Methods: Three patients with localized prostate cancer retrospectively selected from our institution were studied. For each patient, IMPT plans were designed using two, three and four beam angles, respectively, obtained from a beam angle optimization algorithm. Those plans were then compared with ones using two lateral parallel-opposed beams according to the conventional planning protocol for localized prostate cancer adopted at our institution. Results: IMPT plans with two optimized angles achieved significant improvements in rectum sparing and moderate improvements in bladder sparing against those with two lateral angles. Plans with three optimized angles further improved rectum sparing significantly over those two-angle plans, whereas four-angle plans found no advantage over three-angle plans. A possible three-beam class solution for localized prostate patients was suggested and demonstrated with preserved dosimetric benefits because individually optimized three-angle solutions were found sharing a very similar pattern. Conclusions: This study has demonstrated the potential of using an improved beam angle arrangement to better exploit the theoretical dosimetric benefits of proton therapy and provided insights of selecting quality beam angles for localized prostate cancer treatment

  16. Peculiar time dependence of unexpected lines in delayed beam-foil X-ray spectra of V, Fe and Ni

    International Nuclear Information System (INIS)

    Ahmad, Nissar; Karn, Ranjeet K.; Marketos, Pan; Nandi, T.

    2005-01-01

    Delayed beam-foil X-ray spectra of highly charged ions of V, Fe and Ni show a few lines at energies higher than the H-like Lyman α-line of the respective projectile ions. These can only be attributed to heavier ions. Further the time dependence of such unexpected lines display a peculiar behavior. This work presents the experimental observations systematically

  17. Computer-assisted selection of coplanar beam orientations in intensity-modulated radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Pugachev, A.; Xing, L. [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA (United States)]. E-mail: lei@reyes.stanford.edu

    2001-09-01

    In intensity-modulated radiation therapy (IMRT), the incident beam orientations are often determined by a trial and error search. The conventional beam's-eye view (BEV) tool becomes less helpful in IMRT because it is frequently required that beams go through organs at risk (OARs) in order to achieve a compromise between the dosimetric objectives of the planning target volume (PTV) and the OARs. In this paper, we report a beam's-eye view dosimetrics (BEVD) technique to assist in the selection of beam orientations in IMRT. In our method, each beam portal is divided into a grid of beamlets. A score function is introduced to measure the 'goodness' of each beamlet at a given gantry angle. The score is determined by the maximum PTV dose deliverable by the beamlet without exceeding the tolerance doses of the OARs and normal tissue located in the path of the beamlet. The overall score of the gantry angle is given by a sum of the scores of all beamlets. For a given patient, the score function is evaluated for each possible beam orientation. The directions with the highest scores are then selected as the candidates for beam placement. This procedure is similar to the BEV approach used in conventional radiation therapy, except that the evaluation by a human is replaced by a score function to take into account the intensity modulation. This technique allows one to select beam orientations without the excessive computing overhead of computer optimization of beam orientation. It also provides useful insight into the problem of selection of beam orientation and is especially valuable for complicated cases where the PTV is surrounded by several sensitive structures and where it is difficult to select a set of 'good' beam orientations. Several two-dimensional (2D) model cases were used to test the proposed technique. The plans obtained using the BEVD-selected beam orientations were compared with the plans obtained using equiangular spaced beams. For

  18. Metrology and quality of radiation therapy dosimetry of electron, photon and epithermal neutron beams

    Energy Technology Data Exchange (ETDEWEB)

    Kosunen, A

    1999-08-01

    In radiation therapy using electron and photon beams the dosimetry chain consists of several sequential phases starting by the realisation of the dose quantity in the Primary Standard Dosimetry Laboratory and ending to the calculation of the dose to a patient. A similar procedure can be described for the dosimetry of epithermal neutron beams in boron neutron capture therapy (BNCT). To achieve the required accuracy of the dose delivered to a patient the quality of all steps in the dosimetry procedure has to be considered. This work is focused on two items in the dosimetry chains: the determination of the dose in the reference conditions and the evaluation of the accuracy of dose calculation methods. The issues investigated and discussed in detail are: a)the calibration methods of plane parallel ionisation chambers used in electron beam dosimetry, (b) the specification of the critical dosimetric parameter i.e. the ratio of stopping powers for water to air, (S I ?){sup water} {sub air}, in photon beams, (c) the feasibility of the twin ionization chamber technique for dosimetry in epithermal neutron beams applied to BNCT and (d) the determination accuracy of the calculated dose distributions in phantoms in electron, photon, and epithermal neutron beams. The results demonstrate that up to a 3% improvement in the consistency of dose determinations in electron beams is achieved by the calibration of plane parallel ionisation chambers in high energy electron beams instead of calibrations in {sup 60}Co gamma beams. In photon beam dosimetry (S I ?){sup water} {sub air} can be determined with an accuracy of 0.2% using the percentage dose at the 10 cm depth, %dd(10), as a beam specifier. The use of %odd(10) requires the elimination of the electron contamination in the photon beam. By a twin ionisation chamber technique the gamma dose can be determined with uncertainty of 6% (1 standard deviation) and the total neutron dose with an uncertainty of 15 to 20% (1 standard deviation

  19. Metrology and quality of radiation therapy dosimetry of electron, photon and epithermal neutron beams

    International Nuclear Information System (INIS)

    Kosunen, A.

    1999-08-01

    In radiation therapy using electron and photon beams the dosimetry chain consists of several sequential phases starting by the realisation of the dose quantity in the Primary Standard Dosimetry Laboratory and ending to the calculation of the dose to a patient. A similar procedure can be described for the dosimetry of epithermal neutron beams in boron neutron capture therapy (BNCT). To achieve the required accuracy of the dose delivered to a patient the quality of all steps in the dosimetry procedure has to be considered. This work is focused on two items in the dosimetry chains: the determination of the dose in the reference conditions and the evaluation of the accuracy of dose calculation methods. The issues investigated and discussed in detail are: a)the calibration methods of plane parallel ionisation chambers used in electron beam dosimetry, (b) the specification of the critical dosimetric parameter i.e. the ratio of stopping powers for water to air, (S I ?) water air , in photon beams, (c) the feasibility of the twin ionization chamber technique for dosimetry in epithermal neutron beams applied to BNCT and (d) the determination accuracy of the calculated dose distributions in phantoms in electron, photon, and epithermal neutron beams. The results demonstrate that up to a 3% improvement in the consistency of dose determinations in electron beams is achieved by the calibration of plane parallel ionisation chambers in high energy electron beams instead of calibrations in 60 Co gamma beams. In photon beam dosimetry (S I ?) water air can be determined with an accuracy of 0.2% using the percentage dose at the 10 cm depth, %dd(10), as a beam specifier. The use of %odd(10) requires the elimination of the electron contamination in the photon beam. By a twin ionisation chamber technique the gamma dose can be determined with uncertainty of 6% (1 standard deviation) and the total neutron dose with an uncertainty of 15 to 20% (1 standard deviation). To improve the accuracy

  20. Contrast of HOLZ lines in energy-filtered convergent-beam electron diffraction patterns from silicon

    International Nuclear Information System (INIS)

    Lehmpfuhl, G.; Krahl, D.; Uchida, Y.

    1995-01-01

    Higher-order Laue-zone (HOLZ) lines were investigated in convergent-beam electron diffraction patterns from silicon near the low-indexed zone axes [100], [110] and [111]. The visibility of these lines depends on the effective structure potentials of the reflections from the first Laue zone depending on their Debye-Waller factor. The contrast of the HOLZ lines is strongly reduced by inelastically scattered electrons. They can be excluded by an imaging Ω filter for energy losses above 2 eV. The diffraction patterns were compared with many-beam calculations. Without absorption, an excellent agreement could be achieved for the [111] and [100] zone axes, while the simulation of the [110] zone-axis pattern needed a calculation with absorption. The reason for this observation is explained in the Bloch-wave picture. Calculations with absorption, however, lead to artefacts in the intensity distribution of the [100] HOLZ pattern. In order to obtain agreement with the experiment, the Debye-Waller factor had to be modified in different ways for the different zone axes. This corresponds to a strong anisotropy of the Debye-Waller factor. To confirm this observation, the temperature dependence of the itensity distributions of the HOLZ patterns was investigated between 50 and 680 K. At room temperature, the parameter D in the Debye-Waller factor exp(-Ds 2 ) was determined as 0.13, 0.26 and 0.55 A 2 for the zone axes [100], [111] and [110], respectively. The reliability of the conclusions is discussed. (orig.)

  1. IDENTIFIKASI PROFIL DASAR LAUT MENGGUNAKAN INSTRUMEN SIDE SCAN SONAR DENGAN METODE BEAM PATTERN DISCRETE-EQUI-SPACED UNSHADED LINE ARRAY

    Directory of Open Access Journals (Sweden)

    Muhammad Zainuddin Lubis

    2017-05-01

    Full Text Available Laut Punggur merupakan laut yang terletak di Batam, Kepulauan Riau yang mempunyai beragam habitat objek,dan bentuk struktur bawah laut yang memiliki dinamika laut yang sangat tinggi. Side scan sonar (SSS merupakan instrumen pengembangan sistem sonar yang mampu menunjukkan dalam gambar dua dimensional permukaan dasar laut dengan kondisi kontur, topografi, dan target secara bersamaan. Metode Beam Pattern Discrete-Equi-Spaced Unshaded Line Array digunakan untuk menghitung beam pattern dua dimensi yang tergantung pada sudut dari gelombang suara yang masuk dari sumbu array yang diterima tergantung pada sudut di mana sinar suara pada array. Penelitian ini dilakukan pada Desember 2016 di laut Punggur,Batam, Kepulauan Riau-Indonesia, dengan koordinat 104 ° 08,7102 E dan 1° 03,2448 N sampai 1 ° 03.3977 N dan 104 ° 08,8133 E, menggunakan instrumen Side Scan Sonar C-Max CM2 Tow fish dengan frekuensi 325 kHz. Hasil yang diperoleh dari perekaman terdapat 7 target, dan Beam pattern dari metode Beam Discrete-Equi-Spaced Unshaded Line Array target 4 memiliki nilai tertinggi pada directivity Pattern yaitu 21.08 dB. Hasil model beam pattern ini memiliki nilai pusat pada incidence angle (o terhadap Directivity pattern (dB tidak berada di nilai 0 ataupun pada pusat beam pattern yang dihasilkan pada target 6 dengan nilai incident angle -1.5 o dan 1.5o mengalami penurunan hingga -40 dB. Karakteristik sedimen dasar perairan di laut punggur ditemukan lebih banyak pasir. Hasil metode Beam Discrete-Equi-Spaced Unshaded Line Array ditemukan bangkai kapal tenggelam.Kata Kunci: Side Scan Sonar, Beam Pattern Discrete-Equi-Spaced Unshaded Line Array, Incidence angle, Directivity pattern IDENTIFICATION OF SEABED PROFILE USING SIDE SCAN SONAR INSTRUMENT WITH PATTERN DISCRETE-EQUI-SPACED UNSHADED LINE ARRAY METHODRiau Islands is an island that has a variety of habitat objects, and forms of submarine structures that have a very high ocean dynamics, Punggur Sea is the sea

  2. Feature-based plan adaptation for fast treatment planning in scanned ion beam therapy

    International Nuclear Information System (INIS)

    Chen Wenjing; Gemmel, Alexander; Rietzel, Eike

    2013-01-01

    We propose a plan adaptation method for fast treatment plan generation in scanned ion beam therapy. Analysis of optimized treatment plans with carbon ions indicates that the particle number modulation of consecutive rasterspots in depth shows little variation throughout target volumes with convex shape. Thus, we extract a depth-modulation curve (DMC) from existing reference plans and adapt it for creation of new plans in similar treatment situations. The proposed method is tested with seven CT serials of prostate patients and three digital phantom datasets generated with the MATLAB code. Plans are generated with a treatment planning software developed by GSI using single-field uniform dose optimization for all the CT datasets to serve as reference plans and ‘gold standard’. The adapted plans are generated based on the DMC derived from the reference plans of the same patient (intra-patient), different patient (inter-patient) and phantoms (phantom-patient). They are compared with the reference plans and a re-positioning strategy. Generally, in 1 min on a standard PC, either a physical plan or a biological plan can be generated with the adaptive method provided that the new target contour is available. In all the cases, the V95 values of the adapted plans can achieve 97% for either physical or biological plans. V107 is always 0 indicating no overdosage, and target dose homogeneity is above 0.98 in all cases. The dose received by the organs at risk is comparable to the optimized plans. The plan adaptation method has the potential for on-line adaptation to deal with inter-fractional motion, as well as fast off-line treatment planning, with either the prescribed physical dose or the RBE-weighted dose. (paper)

  3. Design of a synchrotron radiation detector for the test beam lines at the Superconducting Super Collider Laboratory

    International Nuclear Information System (INIS)

    Hutton, R.D.

    1994-01-01

    As part of the particle- and momentum-tagging instrumentation required for the test beam lines of the Superconducting Super Collider (SSC), the synchrotron radiation detector (SRD) was designed to provide electron tagging at momentum above 75 GeV. In a parallel effort to the three test beam lines at the SSC, schedule demands required testing and calibration operations to be initiated at Fermilab. Synchrotron radiation detectors also were to be installed in the NM and MW beam lines at Femilab before the test beam lines at the SSC would become operational. The SRD is the last instrument in a series of three used in the SSC test beam fines. It follows a 20-m drift section of beam tube downstream of the last silicon strip detector. A bending dipole just in of the last silicon strip detector produces the synchrotron radiation that is detected in a 50-mm-square cross section NaI crystal. A secondary scintillator made of Bicron BC-400 plastic is used to discriminate whether it is synchrotron radiation or a stray particle that causes the triggering of the NaI crystal's photo multiplier tube (PMT)

  4. The influence of lateral beam profile modifications in scanned proton and carbon ion therapy: a Monte Carlo study

    CERN Document Server

    Parodi, K; Kraemer, M; Sommerer, F; Naumann, J; Mairani, A; Brons, S

    2010-01-01

    Scanned ion beam delivery promises superior flexibility and accuracy for highly conformal tumour therapy in comparison to the usage of passive beam shaping systems. The attainable precision demands correct overlapping of the pencil-like beams which build up the entire dose distribution in the treatment field. In particular, improper dose application due to deviations of the lateral beam profiles from the nominal planning conditions must be prevented via appropriate beam monitoring in the beamline, prior to the entrance in the patient. To assess the necessary tolerance thresholds of the beam monitoring system at the Heidelberg Ion Beam Therapy Center, Germany, this study has investigated several worst-case scenarios for a sensitive treatment plan, namely scanned proton and carbon ion delivery to a small target volume at a shallow depth. Deviations from the nominal lateral beam profiles were simulated, which may occur because of misaligned elements or changes of the beam optic in the beamline. Data have been an...

  5. Radiation optic neuropathy after external beam radiation therapy for acromegaly: report of two cases

    International Nuclear Information System (INIS)

    Bergh, Alfons C.M. van den; Hoving, Marjanke A.; Links, Thera P.; Dullaart, Robin P.F.; Ranchor, Adelita V.; Weeme, Cees A. ter; Canrinus, Alof A.; Szabo, Ben G.; Pott, Jan-Willem R.

    2003-01-01

    For diagnosing radiation optic neuropathy (RON) ophthalmological and imaging data were evaluated from 63 acromegalic patients, irradiated between 1967 and 1998. Two patients developed RON: one patient in one optic nerve 10 years and another patient in both optic nerves 5 months after radiation therapy. RON is a rare complication after external beam radiation therapy for acromegaly, which can occur after a considerable latency period

  6. SU-F-J-202: Secondary Radiation Measurements for Charged Particle Therapy Monitoring: Fragmentation of Therapeutic He, C and O Ion Beams Impinging On a PMMA Target

    Energy Technology Data Exchange (ETDEWEB)

    Rucinski, A; Mancini-Terracciano, C; Paramatti, R; Pinci, D; Russomando, A; Voena, C [Istituto Nazionale di Fisica Nucleare - Sezione di Roma, Rome, Rome (Italy); Battistoni, G; Muraro, S [Istituto Nazionale di Fisica Nucleare - Sezione di Milano, Milano, Milano (Italy); Collamati, F; Faccini, R; Camillocci, E Solfaroli [Istituto Nazionale di Fisica Nucleare - Sezione di Roma, Italy, Dipartiment, Rome, Rome (Italy); Collini, F [Istituto Nazionale di Fisica Nucleare - Sezione di Pisa, Pisa, Pisa (Italy); De Lucia, E; Piersanti, L; Toppi, M [Laboratori Nazionali di Frascati, Frascati (rome), Rome (Italy); Frallicciardi, P [Museo Storico della Fisica e Centro Studi e Ricerche E. Fermi, Rome, Rome (Italy); Marafini, M [Istituto Nazionale di Fisica Nucleare - Sezione di Roma, Museo Storico dell, Rome, Rome (Italy); Patera, V; Sciubba, A; Traini, G [Istituto Nazionale di Fisica Nucleare - Sezione di Roma, Dipartimento di Sc, Rome, Rome (Italy); and others

    2016-06-15

    Purpose: In Charged Particle Therapy (CPT), besides protons, there has been recently a growing interest in 4He, 12C and 16O beams. The secondary radiation produced in the interaction of those beams with a patient could be potentially used for on-line monitoring of range uncertainties in order to fully exploit the advantages of those light ions resulting from increased Radio Biological Effectiveness, reduced multiple scattering and Oxygen Enhancement Ratio. The study and precise characterization of secondary radiation (beta+, prompt gamma, charged fragments) is the cornerstone of any R&D activity aiming for online monitoring development and purpose of the analysis presented here. Methods: We present the measurements of the secondary radiation generated by He, C and O beams impinging on a beam stopping PMMA target. The data has been collected at the Heidelberg Ionbeam Therapy center (HIT), where several millions of collisions were recorded at different energies, relevant for therapeutical applications. Results: The experimental setup, as well as the analysis strategies will be reviewed. The detected particle fluxes as a function of the primary beam energy and the emission angle with respect to the beam direction will be presented and compared to the results of other available measurements. In addition, the energy spectra and emission shapes of charged secondary particles will be shown and discussed in the context of the primary beam range monitoring technique that is being developed by the ARPG collaboration, within the INSIDE project funded by the Italian research ministry. The implications for dose monitoring applications will be discussed, in the context of the current (or planned) state-of- the-art detector solutions. Conclusion: The characterization of the radiation produced by 12C, 4He and 16O beams fully supports the feasibility of on-line range monitoring in the clinical practice of CPT by means of secondary particles detection.

  7. SU-F-J-202: Secondary Radiation Measurements for Charged Particle Therapy Monitoring: Fragmentation of Therapeutic He, C and O Ion Beams Impinging On a PMMA Target

    International Nuclear Information System (INIS)

    Rucinski, A; Mancini-Terracciano, C; Paramatti, R; Pinci, D; Russomando, A; Voena, C; Battistoni, G; Muraro, S; Collamati, F; Faccini, R; Camillocci, E Solfaroli; Collini, F; De Lucia, E; Piersanti, L; Toppi, M; Frallicciardi, P; Marafini, M; Patera, V; Sciubba, A; Traini, G

    2016-01-01

    Purpose: In Charged Particle Therapy (CPT), besides protons, there has been recently a growing interest in 4He, 12C and 16O beams. The secondary radiation produced in the interaction of those beams with a patient could be potentially used for on-line monitoring of range uncertainties in order to fully exploit the advantages of those light ions resulting from increased Radio Biological Effectiveness, reduced multiple scattering and Oxygen Enhancement Ratio. The study and precise characterization of secondary radiation (beta+, prompt gamma, charged fragments) is the cornerstone of any R&D activity aiming for online monitoring development and purpose of the analysis presented here. Methods: We present the measurements of the secondary radiation generated by He, C and O beams impinging on a beam stopping PMMA target. The data has been collected at the Heidelberg Ionbeam Therapy center (HIT), where several millions of collisions were recorded at different energies, relevant for therapeutical applications. Results: The experimental setup, as well as the analysis strategies will be reviewed. The detected particle fluxes as a function of the primary beam energy and the emission angle with respect to the beam direction will be presented and compared to the results of other available measurements. In addition, the energy spectra and emission shapes of charged secondary particles will be shown and discussed in the context of the primary beam range monitoring technique that is being developed by the ARPG collaboration, within the INSIDE project funded by the Italian research ministry. The implications for dose monitoring applications will be discussed, in the context of the current (or planned) state-of- the-art detector solutions. Conclusion: The characterization of the radiation produced by 12C, 4He and 16O beams fully supports the feasibility of on-line range monitoring in the clinical practice of CPT by means of secondary particles detection.

  8. TU-H-BRA-07: Design, Construction, and Installation of An Experimental Beam Line for the Development of MRI-Linac Compatible Electron Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Whelan, B; Keall, P [University of Sydney, Sydney (Australia); Holloway, L [Liverpool Hospital and Ingham Institute, Liverpool, NSW (United Kingdom); Gierman, S; Schmerge, J; Tantawi, S; Tremaine, A; Trautwein, A; Scott, B [Stanford Linear Accelerator Facility, Palo Alto, CA (United States); Fahrig, R [Siemens Healthcare GmbH, Forchheim (Germany)

    2016-06-15

    Purpose: MRI guided radiation therapy (MRIgRT) is a rapidly growing field; however, Linac operation in MRI fringe fields represents an ongoing challenge. We have previously shown in-silico that Linacs could be redesigned to function in the in-line orientation with no magnetic shielding by adopting an RF-gun configuration. Other authors have also published insilico studies of Linac operation in magnetic fields; however to date no experimental validation data is published. This work details the design, construction, and installation of an experimental beam line to validate our in-silico results. Methods: An RF-gun comprising 1.5 accelerating cells and capable of generating electron energies up to 3.2MeV is used. The experimental apparatus was designed to monitor both beam current (toroid current monitor), spot size (two phosphor screens with viewports), and generate peak magnetic fields of at least 1000G (three variable current electromagnetic coils). Thermal FEM simulations were developed to ensure coil temperature remained within 100degC. Other design considerations included beam disposal, vacuum maintenance, radiation shielding, earthquake safety, and machine protection interlocks. Results: The beam line has been designed, built, and installed in a radiation shielded bunker. Water cooling, power supplies, thermo-couples, cameras, and radiation shielding have been successfully connected and tested. Interlock testing, vacuum processing, and RF processing have been successfully completed. The first beam on is expected within weeks. The coil heating simulations show that with care, peak fields of up to 1200G (320G at cathode) can be produced using 40A current, which is well within the fields expected for MRI-Linac systems. The maximum coil temperature at this current was 84degC after 6 minutes. Conclusion: An experimental beam line has been constructed and installed at SLAC in order to experimentally characterise RF gun performance in in-line magnetic fields, validate

  9. TU-H-BRA-07: Design, Construction, and Installation of An Experimental Beam Line for the Development of MRI-Linac Compatible Electron Accelerator

    International Nuclear Information System (INIS)

    Whelan, B; Keall, P; Holloway, L; Gierman, S; Schmerge, J; Tantawi, S; Tremaine, A; Trautwein, A; Scott, B; Fahrig, R

    2016-01-01

    Purpose: MRI guided radiation therapy (MRIgRT) is a rapidly growing field; however, Linac operation in MRI fringe fields represents an ongoing challenge. We have previously shown in-silico that Linacs could be redesigned to function in the in-line orientation with no magnetic shielding by adopting an RF-gun configuration. Other authors have also published insilico studies of Linac operation in magnetic fields; however to date no experimental validation data is published. This work details the design, construction, and installation of an experimental beam line to validate our in-silico results. Methods: An RF-gun comprising 1.5 accelerating cells and capable of generating electron energies up to 3.2MeV is used. The experimental apparatus was designed to monitor both beam current (toroid current monitor), spot size (two phosphor screens with viewports), and generate peak magnetic fields of at least 1000G (three variable current electromagnetic coils). Thermal FEM simulations were developed to ensure coil temperature remained within 100degC. Other design considerations included beam disposal, vacuum maintenance, radiation shielding, earthquake safety, and machine protection interlocks. Results: The beam line has been designed, built, and installed in a radiation shielded bunker. Water cooling, power supplies, thermo-couples, cameras, and radiation shielding have been successfully connected and tested. Interlock testing, vacuum processing, and RF processing have been successfully completed. The first beam on is expected within weeks. The coil heating simulations show that with care, peak fields of up to 1200G (320G at cathode) can be produced using 40A current, which is well within the fields expected for MRI-Linac systems. The maximum coil temperature at this current was 84degC after 6 minutes. Conclusion: An experimental beam line has been constructed and installed at SLAC in order to experimentally characterise RF gun performance in in-line magnetic fields, validate

  10. Measurement of secondary radiation during ion beam therapy with the pixel detector Timepix

    Science.gov (United States)

    Martišíková, Mária; Jakubek, Jan; Granja, Carlos; Hartmann, Bernadette; Opálka, Lukáš; Pospíšil, Stanislav; Jäkel, Oliver

    2011-11-01

    In ion beam therapy the finite range of the ion beams in tissue and the presence of the Bragg-peak are exploited. Unpredictable changes in the patient`s condition can alter the range of the ion beam in the body. Therefore it is desired to verify the actual ion range during the treatment, preferably in a non-invasive way. Positron emission tomography (PET) has been used successfully to monitor the applied dose distributions. This method however suffers from limited applicability and low detection efficiency. In order to increase the detection efficiency and to decrease the uncertainties, in this study we investigate the possibility to measure secondary charged particles emerging from the patient during irradiation. An initial experimental study to register the particle radiation coming out of a patient phantom during the therapy was performed at the Heidelberg Ion Beam Therapy Center (HIT) in Germany. A static narrowly-focused beam of carbon ions was directed into a head phantom. The emerging secondary radiation was measured with the position-sensitive Timepix detector outside of the phantom. The detector, developed by the Medipix Collaboration, consists of a silicon sensor bump bonded to a pixelated readout chip (256 × 256 pixels with 55 μm pitch). Together with the USB-based readout interface, Timepix can operate as an active nuclear emulsion registering single particles online with 2D-track visualization. In this contribution we measured the signal behind the head phantom and investigated its dependence on the beam energy (corresponding to beam range in water 2-30 cm). Furthermore, the response was measured at four angles between 0 and 90 degrees. At all investigated energies some signal was registered. Its pattern corresponds to ions. Differences in the total amount of signal for different beam energies were observed. The time-structure of the signal is correlated with that of the incoming beam, showing that we register products of prompt processes. Such

  11. Measurement of secondary radiation during ion beam therapy with the pixel detector Timepix

    International Nuclear Information System (INIS)

    Martišíková, Mária; Hartmann, Bernadette; Jäkel, Oliver; Jakubek, Jan; Granja, Carlos; Opálka, Lukáš; Pospíšil, Stanislav

    2011-01-01

    In ion beam therapy the finite range of the ion beams in tissue and the presence of the Bragg-peak are exploited. Unpredictable changes in the patient's condition can alter the range of the ion beam in the body. Therefore it is desired to verify the actual ion range during the treatment, preferably in a non-invasive way. Positron emission tomography (PET) has been used successfully to monitor the applied dose distributions. This method however suffers from limited applicability and low detection efficiency. In order to increase the detection efficiency and to decrease the uncertainties, in this study we investigate the possibility to measure secondary charged particles emerging from the patient during irradiation. An initial experimental study to register the particle radiation coming out of a patient phantom during the therapy was performed at the Heidelberg Ion Beam Therapy Center (HIT) in Germany. A static narrowly-focused beam of carbon ions was directed into a head phantom. The emerging secondary radiation was measured with the position-sensitive Timepix detector outside of the phantom. The detector, developed by the Medipix Collaboration, consists of a silicon sensor bump bonded to a pixelated readout chip (256 × 256 pixels with 55 μm pitch). Together with the USB-based readout interface, Timepix can operate as an active nuclear emulsion registering single particles online with 2D-track visualization. In this contribution we measured the signal behind the head phantom and investigated its dependence on the beam energy (corresponding to beam range in water 2–30 cm). Furthermore, the response was measured at four angles between 0 and 90 degrees. At all investigated energies some signal was registered. Its pattern corresponds to ions. Differences in the total amount of signal for different beam energies were observed. The time-structure of the signal is correlated with that of the incoming beam, showing that we register products of prompt processes. Such

  12. Phase II Radiation therapy oncology group trial of weekly paclitaxel and conventional external beam radiation therapy for supratentorial glioblastoma multiforme

    International Nuclear Information System (INIS)

    Langer, Corey J.; Ruffer, James; Rhodes, Harker; Paulus, Rebecca; Murray, Kevin; Movsas, Benjamin; Curran, Walter

    2001-01-01

    Purpose: Fractionated external beam radiotherapy (EBRT) ± carmustine (BCNU) is the standard of care for patients with glioblastoma multiforme (GBM), but survival results remain poor. Preclinical studies indicate synergy between RT and paclitaxel (TAX) in astrocytoma cell lines. Phase I studies in GBM have demonstrated a maximum tolerated dose for TAX of 225 mg/m 2 /3 h/week x 6, during EBRT, with no exacerbation of typical RT-induced toxicities. The Radiation Therapy Oncology Group (RTOG) therefore mounted a Phase II study to determine the feasibility and efficacy of conventional EBRT and concurrent weekly TAX at its MTD. Patients and Methods: Sixty-two patients with histologic diagnosis of GBM were enrolled from 8/16/96 through 3/21/97 in a multi-institutional Phase II trial of EBRT and TAX 225 mg/m 2 /3 h (1-3 h before EBRT), administered the first treatment day of each RT week. Total EBRT dose was 60 Gy (200 cGy/fraction), 5 days per week. A smaller treatment field, to include gross disease plus a margin only, was used after 46 Gy. Results: Sixty-one patients (98%) were evaluable. Median age was 55 years (range, 28-78). Seventy-four percent were ≥50 years. Recursive partitioning analysis (RPA) Classes III, IV, V, VI included 10 (17%), 21 (34%), 25 (41%), and 5 (8%) patients, respectively. Gross total resection was performed in only 16%. There was no Grade 3 or 4 neutropenia or thrombocytopenia. Hypersensitivity reactions precluding further use of TAX occurred in 4 patients. There were 2 instances of late neurotoxicity (4% Grade 3 or 4). Ninety-one percent of patients received treatment per protocol. Seventy-seven percent completed prescribed treatment (6 weeks). Of 35 patients with measurable disease, CR/PR was observed in 23%, MR in 17%, and SD in 43%. Seventeen percent demonstrated progression at first follow-up. Median potential follow-up time is 20 months. Median survival is 9.7 months, with median survivals for RPA classes III, IV, V, and VI of 16.3, 10

  13. European protocol for neutron dosimetry for external beam therapy

    International Nuclear Information System (INIS)

    Broerse, J.J.; Mijnheer, B.J.; Williams, J.R.

    1981-01-01

    The paper attempts to serve the needs of European centres participating in the High LET Therapy Project Group set up under the sponsorship of The European Organization for Research on Treatment of Cancer, to promote cooperation between physicists involved in fast neutron therapy and establish a common basis for neutron dosimetry. Differences in dosimetry procedures between European and American Groups are indicated if relevant. The subject is dealt with under the following main headings: principles of dosimetry of neutron fields, dosimetric methods, physical parameters, determination of absorbed dose at a reference point, determination of absorbed dose at any point, check of absorbed dose given to a patient, dosimetry intercomparisons between institutes. There is an ample bibliography. (U.K.)

  14. Maximum dose angle for oblique incidence on primary beam protective barriers in the design of medical radiation therapy facilities

    International Nuclear Information System (INIS)

    Fondevila, Damian; Arbiser, Silvio; Sansogne, Rosana; Brunetto, Monica; Dosoretz, Bernardo

    2008-01-01

    Primary barrier determinations for the shielding of medical radiation therapy facilities are generally made assuming normal beam incidence on the barrier, since this is geometrically the most unfavorable condition for that shielding barrier whenever the occupation line is allowed to run along the barrier. However, when the occupation line (for example, the wall of an adjacent building) runs perpendicular to the barrier (especially roof barrier), then two opposing factors come in to play: increasing obliquity angle with respect to the barrier increases the attenuation, while the distance to the calculation point decreases, hence, increasing the dose. As a result, there exists an angle (α max ) for which the equivalent dose results in a maximum, constituting the most unfavorable geometric condition for that shielding barrier. Based on the usual NCRP Report No. 151 model, this article presents a simple formula for obtaining α max , which is a function of the thickness of the barrier (t E ) and the equilibrium tenth-value layer (TVL e ) of the shielding material for the nominal energy of the beam. It can be seen that α max increases for increasing TVL e (hence, beam energy) and decreases for increasing t E , with a range of variation that goes from 13 to 40 deg for concrete barriers thicknesses in the range of 50-300 cm and most commercially available teletherapy machines. This parameter has not been calculated in the existing literature for radiotherapy facilities design and has practical applications, as in calculating the required unoccupied roof shielding for the protection of a nearby building located in the plane of the primary beam rotation

  15. Maximum dose angle for oblique incidence on primary beam protective barriers in the design of medical radiation therapy facilities.

    Science.gov (United States)

    Fondevila, Damián; Arbiser, Silvio; Sansogne, Rosana; Brunetto, Mónica; Dosoretz, Bernardo

    2008-05-01

    Primary barrier determinations for the shielding of medical radiation therapy facilities are generally made assuming normal beam incidence on the barrier, since this is geometrically the most unfavorable condition for that shielding barrier whenever the occupation line is allowed to run along the barrier. However, when the occupation line (for example, the wall of an adjacent building) runs perpendicular to the barrier (especially roof barrier), then two opposing factors come in to play: increasing obliquity angle with respect to the barrier increases the attenuation, while the distance to the calculation point decreases, hence, increasing the dose. As a result, there exists an angle (alpha(max)) for which the equivalent dose results in a maximum, constituting the most unfavorable geometric condition for that shielding barrier. Based on the usual NCRP Report No. 151 model, this article presents a simple formula for obtaining alpha(max), which is a function of the thickness of the barrier (t(E)) and the equilibrium tenth-value layer (TVL(e)) of the shielding material for the nominal energy of the beam. It can be seen that alpha(max) increases for increasing TVL(e) (hence, beam energy) and decreases for increasing t(E), with a range of variation that goes from 13 to 40 deg for concrete barriers thicknesses in the range of 50-300 cm and most commercially available teletherapy machines. This parameter has not been calculated in the existing literature for radiotherapy facilities design and has practical applications, as in calculating the required unoccupied roof shielding for the protection of a nearby building located in the plane of the primary beam rotation.

  16. Dynamic Target Definition: A novel approach for PTV definition in ion beam therapy

    International Nuclear Information System (INIS)

    Cabal, Gonzalo A.; Jäkel, Oliver

    2013-01-01

    Purpose: To present a beam arrangement specific approach for PTV definition in ion beam therapy. Materials and methods: By means of a Monte Carlo error propagation analysis a criteria is formulated to assess whether a voxel is safely treated. Based on this a non-isotropical expansion rule is proposed aiming to minimize the impact of uncertainties on the dose delivered. Results: The method is exemplified in two cases: a Head and Neck case and a Prostate case. In both cases the modality used is proton beam irradiation and the sources of uncertainties taken into account are positioning (set up) errors and range uncertainties. It is shown how different beam arrangements have an impact on plan robustness which leads to different target expansions necessary to assure a predefined level of plan robustness. The relevance of appropriate beam angle arrangements as a way to minimize uncertainties is demonstrated. Conclusions: A novel method for PTV definition in on beam therapy is presented. The method show promising results by improving the probability of correct dose CTV coverage while reducing the size of the PTV volume. In a clinical scenario this translates into an enhanced tumor control probability while reducing the volume of healthy tissue being irradiated

  17. The accelerator facility of the Heidelberg Ion-Beam Therapy Centre (HIT)

    Science.gov (United States)

    Peters, Andreas

    The following sections are included: * Introduction * Beam parameters * General layout of the HIT facility * The accelerator chain in detail * Operational aspects of a particle therapy facility * 24/7 accelerator operation at 335 days per year * Safety and regulatory aspects * Status and perspectives * References

  18. Assessment of dose load of personnel in intratissue gamma beam therapy

    International Nuclear Information System (INIS)

    Stavitskij, R.V.; Zamyatin, O.A.; Varennikov, O.I.; Astakhova, I.V.

    1995-01-01

    Suggest a method for retrospective assessment of levels of irradiation of small groups of personnel exposed to radiation sources. Presents estimated values of cumulative and local doses obtained by personnel during intratissue gamma beam therapy carried out by manual consecutive injections of intrastats and irradiation sources. 3 refs.; 5 tabs

  19. A Multiple-room, Continuous Beam Delivery, Hadron-therapy Installation

    Science.gov (United States)

    Méot, F.

    A proton-therapy hospital installation, based on multiple beam extraction systems from a fixed-field synchrotron, is presented and commented. Potential interest as hospital operation efficiency, as well as estimates of the impact of continuous, multiple-port extraction, on the cost of a session, are discussed.

  20. Development of a polarized neutron beam line at Algerian research reactors using McStas software

    Science.gov (United States)

    Makhloufi, M.; Salah, H.

    2017-02-01

    Unpolarized instrumentation has long been studied and designed using McStas simulation tool. But, only recently new models were developed for McStas to simulate polarized neutron scattering instruments. In the present contribution, we used McStas software to design a polarized neutron beam line, taking advantage of the available spectrometers reflectometer and diffractometer in Algeria. Both thermal and cold neutron was considered. The polarization was made by two types of supermirrors polarizers FeSi and CoCu provided by the HZB institute. For sake of performance and comparison, the polarizers were characterized and their characteristics reproduced. The simulated instruments are reported. Flipper and electromagnets for guide field are developed. Further developments including analyzers and upgrading of the existing spectrometers are underway.

  1. Operating experience with LAMPF main beam lines instrumentation and control system

    International Nuclear Information System (INIS)

    van Dyck, O.B.; Harvey, A.; Howard, H.H.; Roeder, D.L.

    1975-01-01

    Instrumentation and control (I and C) for the Los Alamos Clinton P. Anderson Meson Physics Facility (LAMPF) main beam line is based upon central computer control through remote stations which provide input and output to most devices. Operating experience shows that the ability of the computer to give high-quality graphical presentation of the measurements enhances operator performance and instrument usefulness. Experience also shows that operator efficiency degrades rapidly with increasing instrument response time, that is, with increasing delay between the time a control is changed and the result can be observed. For this reason, instrumentation upgrade includes speeding up data acquisition and display times to under 10 s. Similarly, television-viewed phosphors are being retained where possible since their instantaneous response is very useful. Other upgrading of the instrumentation system is planned to improve data accuracy, reliability, redundancy, and instrument radiation tolerance. Past experience is being applied in adding or relocating devices to simplify tuning procedures. (U.S.)

  2. High flux and high resolution VUV beam line for synchrotron radiation

    International Nuclear Information System (INIS)

    Wilcke, H.; Boehmer, W.; Schwentner, N.

    1982-04-01

    A beam line has been optimized for high flux and high resolution in the wavelength range from 30 nm to 300 nm. Sample chambers for luminescence spectroscopy on gaseous, liquid and solid samples and for photoelectron spectroscopy have been integrated. The synchrotron radiation from the storage ring DORIS (at DESY, Hamburg) emitted into 50 mrad in horizontal and into 2.2 mrad in vertical direction is focused by a cylindrical and a plane elliptical mirror into the entrance slit of a 2m normal incidence monochromator. The light flux from the exit slit is focused by a rotational elliptic mirror onto the sample yielding a size of the light spot of 4 x 0.15 mm 2 . The light flux at the sample reaches 7 x 10 12 photons nm -1 s -1 at 8 eV photon energy for a current of 100 mA in DORIS. A resolution of 0.007 nm has been obtained. (orig.)

  3. Multiobjective optimization design of an rf gun based electron diffraction beam line

    Directory of Open Access Journals (Sweden)

    Colwyn Gulliford

    2017-03-01

    Full Text Available Multiobjective genetic algorithm optimizations of a single-shot ultrafast electron diffraction beam line comprised of a 100  MV/m 1.6-cell normal conducting rf (NCRF gun, as well as a nine-cell 2π/3 bunching cavity placed between two solenoids, have been performed. These include optimization of the normalized transverse emittance as a function of bunch charge, as well as optimization of the transverse coherence length as a function of the rms bunch length of the beam at the sample location for a fixed charge of 10^{6} electrons. Analysis of the resulting solutions is discussed in terms of the relevant scaling laws, and a detailed description of one of the resulting solutions from the coherence length optimizations is given. For a charge of 10^{6} electrons and final beam sizes of σ_{x}≥25  μm and σ_{t}≈5  fs, we found a relative coherence length of L_{c,x}/σ_{x}≈0.07 using direct optimization of the coherence length. Additionally, based on optimizations of the emittance as a function of final bunch length, we estimate the relative coherence length for bunch lengths of 30 and 100 fs to be roughly 0.1 and 0.2  nm/μm, respectively. Finally, using the scaling of the optimal emittance with bunch charge, for a charge of 10^{5} electrons, we estimate relative coherence lengths of 0.3, 0.5, and 0.92  nm/μm for final bunch lengths of 5, 30 and 100 fs, respectively.

  4. RAPD and SSR Polymorphisms in Mutant Lines of Transgenic Wheat Mediated by Low Energy Ion Beam

    International Nuclear Information System (INIS)

    Wang Tiegu; Huang Qunce; Feng Weisen

    2007-01-01

    Two types of markers-random amplified polymorphic DNA (RAPD) and simple sequence repeat DNA (SSR)-have been used to characterize the genetic diversity among nine mutant lines of transgenic wheat intermediated by low energy ion beam and their four receptor cultivars. The objectives of this study were to analyze RAPD-based and SSR-based genetic variance among transgenic wheat lines and with their receptors, and to find specific genetic markers of special traits of transgenic wheat lines. 170 RAPD primers were amplified to 733 fragments in all the experimental materials. There were 121 polymorphic fragments out of the 733 fragments with a ratio of polymorphic fragments of 16.5%. 29 SSR primer pairs were amplified to 83 fragments in all the experiment materials. There were 57 polymorphic fragments out of the 83 fragments with a ratio of polymorphic fragments of 68.7%. The dendrograms were prepared based on a genetic distance matrix using the UPGMA (Unweighted Pair-group Method with Arithmetic averaging) algorithm, which corresponded well to the results of the wheat pedigree analysis and separated the 13 genotypes into four groups. Association analysis between RAPD and SSR markers with the special traits of transgenic wheat mutant lines discovered that three RAPD markers, s1, opt-16, and f14, were significantly associated with the muticate trait, while three SSR markers, Rht8 (Xgwm261), Rht-B1b, and Rht-D1b, highly associated with the dwarf trait. These markers will be useful for marker-assistant breeding and can be used as candidate markers for further gene mapping and cloning

  5. RAPD and SSR Polymorphisms in Mutant Lines of Transgenic Wheat Mediated by Low Energy Ion Beam

    Science.gov (United States)

    Wang, Tiegu; Huang, Qunce; Feng, Weisen

    2007-10-01

    Two types of markers-random amplified polymorphic DNA (RAPD) and simple sequence repeat DNA (SSR)-have been used to characterize the genetic diversity among nine mutant lines of transgenic wheat intermediated by low energy ion beam and their four receptor cultivars. The objectives of this study were to analyze RAPD-based and SSR-based genetic variance among transgenic wheat lines and with their receptors, and to find specific genetic markers of special traits of transgenic wheat lines. 170 RAPD primers were amplified to 733 fragments in all the experimental materials. There were 121 polymorphic fragments out of the 733 fragments with a ratio of polymorphic fragments of 16.5%. 29 SSR primer pairs were amplified to 83 fragments in all the experiment materials. There were 57 polymorphic fragments out of the 83 fragments with a ratio of polymorphic fragments of 68.7%. The dendrograms were prepared based on a genetic distance matrix using the UPGMA (Unweighted Pair-group Method with Arithmetic averaging) algorithm, which corresponded well to the results of the wheat pedigree analysis and separated the 13 genotypes into four groups. Association analysis between RAPD and SSR markers with the special traits of transgenic wheat mutant lines discovered that three RAPD markers, s1, opt-16, and f14, were significantly associated with the muticate trait, while three SSR markers, Rht8 (Xgwm261), Rht-B1b, and Rht-D1b, highly associated with the dwarf trait. These markers will be useful for marker-assistant breeding and can be used as candidate markers for further gene mapping and cloning.

  6. RAPD and SSR Polymorphisms in Mutant Lines of Transgenic Wheat Mediated by Low Energy Ion Beam

    Energy Technology Data Exchange (ETDEWEB)

    Tiegu, Wang [Henan Provincial Key Laboratory of Ion Beam Bio-Engineering, Zhengzhou University, Zhengzhou 450052 (China); Qunce, Huang [Henan Provincial Key Laboratory of Ion Beam Bio-Engineering, Zhengzhou University, Zhengzhou 450052 (China); Weisen, Feng [Luoyang Institute of Agricultural Science, Luoyang 471022 (China)

    2007-10-15

    Two types of markers-random amplified polymorphic DNA (RAPD) and simple sequence repeat DNA (SSR)-have been used to characterize the genetic diversity among nine mutant lines of transgenic wheat intermediated by low energy ion beam and their four receptor cultivars. The objectives of this study were to analyze RAPD-based and SSR-based genetic variance among transgenic wheat lines and with their receptors, and to find specific genetic markers of special traits of transgenic wheat lines. 170 RAPD primers were amplified to 733 fragments in all the experimental materials. There were 121 polymorphic fragments out of the 733 fragments with a ratio of polymorphic fragments of 16.5%. 29 SSR primer pairs were amplified to 83 fragments in all the experiment materials. There were 57 polymorphic fragments out of the 83 fragments with a ratio of polymorphic fragments of 68.7%. The dendrograms were prepared based on a genetic distance matrix using the UPGMA (Unweighted Pair-group Method with Arithmetic averaging) algorithm, which corresponded well to the results of the wheat pedigree analysis and separated the 13 genotypes into four groups. Association analysis between RAPD and SSR markers with the special traits of transgenic wheat mutant lines discovered that three RAPD markers, s1, opt-16, and f14, were significantly associated with the muticate trait, while three SSR markers, Rht8 (Xgwm261), Rht-B1b, and Rht-D1b, highly associated with the dwarf trait. These markers will be useful for marker-assistant breeding and can be used as candidate markers for further gene mapping and cloning.

  7. SU-E-J-49: Distal Edge Activity Fall Off Of Proton Therapy Beams

    Energy Technology Data Exchange (ETDEWEB)

    Elmekawy, A; Ewell, L [Hampton University, Hampton, VA (United States); Butuceanu, C; Zhu, L [HUPTI, Hampton, VA (United States)

    2014-06-01

    Purpose: To characterize and quantify the distal edge activity fall off, created in a phantom by a proton therapy beam Method and Materials: A 30x30x10cm polymethylmethacrylate phantom was irradiated with a proton therapy beam using different ranges and beams. The irradiation volume is approximated by a right circular cylinder of diameter 7.6cm and varying lengths. After irradiation, the phantom was scanned via a Philips Gemini Big Bore™ PET-CT for isotope activation. Varian Eclipse™ treatment planning system as well as ImageJ™ were used to analyze the resulting PET and CT scans. The region of activity within the phantom was longitudinally measured as a function of PET slice number. Dose estimations were made via Monte Carlo (GATE) simulation. Results: For both the spread out Bragg peak (SOBP) and the mono-energetic pristine Bragg peak proton beams, the proximal activation rise was steep: average slope −0.735 (average intensity/slice number) ± 0.091 (standard deviation) for the pristine beams and −1.149 ± 0.117 for the SOBP beams. In contrast, the distal fall offs were dissimilar. The distal fall off in activity for the pristine beams was fit well by a linear curve: R{sup 2} (Pierson Product) was 0.9968, 0.9955 and 0.9909 for the 13.5, 17.0 and 21.0cm range beams respectively. The good fit allows for a slope comparison between the different ranges. The slope varied as a function of range from 1.021 for the 13.5cm beam to 0.8407 (average intensity/slice number) for the 21.0cm beam. This dependence can be characterized: −0.0234(average intensity/slice number/cm range). For the SOBP beams, the slopes were significantly less and were also less linear: average slope 0.2628 ± 0.0474, average R{sup 2}=0.9236. Conclusion: The distal activation fall off edge for pristine proton beams was linear and steep. The corresponding quantities for SOBP beams were shallower and less linear. Philips has provided support for this work.

  8. Sweeping-window arc therapy: an implementation of rotational IMRT with automatic beam-weight calculation

    International Nuclear Information System (INIS)

    Cameron, C

    2005-01-01

    Sweeping-window arc therapy (SWAT) is a variation of intensity-modulated radiation therapy (IMRT) with direct aperture optimization (DAO) that is initialized with a leaf sequence of sweeping windows that move back and forth periodically across the target as the gantry rotates. This initial sequence induces modulation in the dose and is assumed to be near enough to a minimum to allow successful optimization, done with simulated annealing, without requiring excessive leaf speeds. Optimal beam weights are calculated analytically, with easy extension to allow for variable beam weights. In this paper SWAT is tested on a phantom model and clinical prostate case. For the phantom, constant and variable beam weights are used. Although further work (in particular, improving the dose model) is required, the results show SWAT to be a feasible approach to generating deliverable dynamic arc treatments that are optimized

  9. Sweeping-window arc therapy: an implementation of rotational IMRT with automatic beam-weight calculation

    Energy Technology Data Exchange (ETDEWEB)

    Cameron, C [Division of Radiation Physics, Department of Radiation Oncology, Stanford Cancer Center, 875 Blake Wilbur Drive, Rm G-233, Stanford, CA 94305-5847 (United States)

    2005-09-21

    Sweeping-window arc therapy (SWAT) is a variation of intensity-modulated radiation therapy (IMRT) with direct aperture optimization (DAO) that is initialized with a leaf sequence of sweeping windows that move back and forth periodically across the target as the gantry rotates. This initial sequence induces modulation in the dose and is assumed to be near enough to a minimum to allow successful optimization, done with simulated annealing, without requiring excessive leaf speeds. Optimal beam weights are calculated analytically, with easy extension to allow for variable beam weights. In this paper SWAT is tested on a phantom model and clinical prostate case. For the phantom, constant and variable beam weights are used. Although further work (in particular, improving the dose model) is required, the results show SWAT to be a feasible approach to generating deliverable dynamic arc treatments that are optimized.

  10. High resolution beam line of the U400M cyclotron and RIB accumulation and cooling in the K4 storage ring

    International Nuclear Information System (INIS)

    Rodin, A.M.; Sidorchuk, S.I.; Stepantsov, S.V.

    1996-01-01

    The high resolution beam line ACCULINNA put into operation on a primary beam line of the JINR U400M cyclotron is discussed in the framework of the TREBLE project. The capability of the beam line for producing radioactive ion beams is demonstrated by means of nuclear fragmentation of the primary 14 N beam, with the energy of 51 MeV · A, on the 170 mg/cm 2 carbon target. Characteristics of the obtained 6 He, 8 He and 8 B radioactive beams are presented. A scheme of accumulation and cooling on the orbit of the storage ring K4 is proposed for a low intensity radioactive beam obtained from this beam line. 8 refs., 6 figs., 1 tab

  11. Superconducting coil manufacturing method for low current dc beam line magnets

    International Nuclear Information System (INIS)

    Satti, J.A.

    1977-01-01

    A method of manufacturing superconducting multipole coils for 40 to 50 kG dc beam line magnets with low current is described. Small coils were built and tested successfully to short sample characteristics. The coils did not train after the first cooldown. The coils are porous and well cooled to cope with mechanical instability and energy deposited in the coil from the beam particles. The coils are wound with insulated strand cable. The cable is shaped rectangularly for winding simplicity and good tolerances. After the coil is wound, the insulated strands are electrically connected in series. This reduces the operating current and, most important, improves the coil quench propagation due to heat conduction of one strand adjacent to the other. A well distributed quench allows the magnet energy to distribute more uniformly to the copper in the superconductor wire, giving self-protected coils. A one-meter long, 43 kG, 6-inch bore tube superconducting dipole is now being fabricated. The porous coil design and coil winding methods are discussed

  12. Mechanical design and development of analyzing magnet for the RIB charge breeder beam line

    International Nuclear Information System (INIS)

    Bhattacharyya, Pranab; Ghosh, Sundeep; Bhattacharya, Mahuwa; Gupta, Anjan Dutta; Pal, Gautam; Naik, Vaishali

    2015-01-01

    An iron dominated analyzing magnet of uniform peak field 0.6 T has been developed for Radioactive Ion Beam (RIB) charge breeder beam line at VECC, Kolkata. It has two room temperature coils made of copper having channels for passage of cooling water. The other important parts of the magnet includes two yokes, two poles, vacuum chamber, view port, iron plates and the support structures. The most important properties of magnets designed and fabricated for this application is the need for high field quality. The magnet assembly has got overall dimensions of 1.1 metres x 0.91 metres x 0.63 metres and the required field uniformity is 6 x 10 -4 over pole width of ± 2.5 cm. The most critical parameter that has to be maintained to achieve the desired magnetic field is the pole gap of 80 ± 0.25 rom.This paper describes in detail about the mechanical design, coil cooling analysis, development and assembly of this magnet. (author)

  13. Multiobjective optimizations of a novel cryocooled dc gun based ultrafast electron diffraction beam line

    Directory of Open Access Journals (Sweden)

    Colwyn Gulliford

    2016-09-01

    Full Text Available We present the results of multiobjective genetic algorithm optimizations of a single-shot ultrafast electron diffraction beam line utilizing a 225 kV dc gun with a novel cryocooled photocathode system and buncher cavity. Optimizations of the transverse projected emittance as a function of bunch charge are presented and discussed in terms of the scaling laws derived in the charge saturation limit. Additionally, optimization of the transverse coherence length as a function of final rms bunch length at the sample location have been performed for three different sample radii: 50, 100, and 200  μm, for two final bunch charges: 10^{5} electrons (16 fC and 10^{6} electrons (160 fC. Example optimal solutions are analyzed, and the effects of disordered induced heating estimated. In particular, a relative coherence length of L_{c,x}/σ_{x}=0.27  nm/μm was obtained for a final bunch charge of 10^{5} electrons and final bunch length of σ_{t}≈100  fs. For a final charge of 10^{6} electrons the cryogun produces L_{c,x}/σ_{x}≈0.1  nm/μm for σ_{t}≈100–200  fs and σ_{x}≥50  μm. These results demonstrate the viability of using genetic algorithms in the design and operation of ultrafast electron diffraction beam lines.

  14. Parallel processing of dose calculation for external photon beam therapy

    International Nuclear Information System (INIS)

    Kunieda, Etsuo; Ando, Yutaka; Tsukamoto, Nobuhiro; Ito, Hisao; Kubo, Atsushi

    1994-01-01

    We implemented external photon beam dose calculation programs into a parallel processor system consisting of Transputers, 32-bit processors especially suitable for multi-processor configuration. Two network conformations, binary-tree and pipeline, were evaluated for rectangular and irregular field dose calculation algorithms. Although computation speed increased in proportion to the number of CPU, substantial overhead caused by inter-processor communication occurred when a smaller computation load was delivered to each processor. On the other hand, for irregular field calculation, which requires more computation capability for each calculation point, the communication overhead was still less even when more than 50 processors were involved. Real-time responses could be expected for more complex algorithms by increasing the number of processors. (author)

  15. Use of a two-dimensional ionization chamber array for proton therapy beam quality assurance

    International Nuclear Information System (INIS)

    Arjomandy, Bijan; Sahoo, Narayan; Ding Xiaoning; Gillin, Michael

    2008-01-01

    Two-dimensional ion chamber arrays are primarily used for conventional and intensity modulated radiotherapy quality assurance. There is no commercial device of such type available on the market that is offered for proton therapy quality assurance. We have investigated suitability of the MatriXX, a commercial two-dimensional ion chamber array detector for proton therapy QA. This device is designed to be used for photon and electron therapy QA. The device is equipped with 32x32 parallel plate ion chambers, each with 4.5 mm diam and 7.62 mm center-to-center separation. A 250 MeV proton beam was used to calibrate the dose measured by this device. The water equivalent thickness of the buildup material was determined to be 3.9 mm using a 160 MeV proton beam. Proton beams of different energies were used to measure the reproducibility of dose output and to evaluate the consistency in the beam flatness and symmetry measured by MatriXX. The output measurement results were compared with the clinical commissioning beam data that were obtained using a 0.6 cc Farmer chamber. The agreement was consistently found to be within 1%. The profiles were compared with film dosimetry and also with ion chamber data in water with an excellent agreement. The device is found to be well suited for quality assurance of proton therapy beams. It provides fast two-dimensional dose distribution information in real time with the accuracy comparable to that of ion chamber measurements and film dosimetry

  16. Practical use of a plastic scintillator for quality assurance of electron beam therapy.

    Science.gov (United States)

    Yogo, Katsunori; Tatsuno, Yuya; Tsuneda, Masato; Aono, Yuki; Mochizuki, Daiki; Fujisawa, Yoshiki; Matsushita, Akihiro; Ishigami, Minoru; Ishiyama, Hiromichi; Hayakawa, Kazushige

    2017-06-07

    Quality assurance (QA) of clinical electron beams is essential for performing accurate and safe radiation therapy. However, with advances in radiation therapy, QA has become increasingly labor-intensive and time-consuming. In this paper, we propose a tissue-equivalent plastic scintillator for quick and easy QA of clinical electron beams. The proposed tool comprises a plastic scintillator plate and a charge-coupled device camera that enable the scintillation light by electron beams to be recorded with high sensitivity and high spatial resolution. Further, the Cerenkov image is directly subtracted from the scintillation image to discriminate Cerenkov emissions and accurately measure the dose profiles of electron beams with high spatial resolution. Compared with conventional methods, discrepancies in the depth profile improved from 7% to 2% in the buildup region via subtractive corrections. Further, the output brightness showed good linearity with dose, good reproducibility (deviations below 1%), and dose rate independence (within 0.5%). The depth of 50% dose measured with the tool, an index of electron beam quality, was within  ±0.5 mm of that obtained with an ionization chamber. Lateral brightness profiles agreed with the lateral dose profiles to within 4% and no significant improvement was obtained using Cerenkov corrections. Field size agreed to within 0.5 mm with those obtained with ionization chamber. For clinical QA of electron boost treatment, a disk scintillator that mimics the shape of a patient's breast is applied. The brightness distribution and dose, calculated using a treatment planning system, was generally acceptable for clinical use, except in limited zones. Overall, the proposed plastic scintillator plate tool efficiently performs QA for electron beam therapy and enables simultaneous verification of output constancy, beam quality, depth, and lateral dose profiles during monthly QAs at lower doses of irradiation (small monitor units, MUs).

  17. Electromagnetic design and development of a combined function horizontal and vertical dipole steerer magnet for medium energy beam transport line

    International Nuclear Information System (INIS)

    Singh, Kumud; Itteera, Janvin; Ukarde, Priti; Teotia, Vikas; Kumar, Prashant; Malhotra, Sanjay; Taly, Y.K.

    2013-01-01

    Medium Energy Beam Transport (MEBT) line is required to match the optical functions between the RFQ and SRF cavities/DTL cavities.The primary function of the MEBT lines is to keep the emittance growth of the output beam as low as possible in a highly space charge environment at low energies. The transverse focusing of the beam is achieved by strong focusing quadrupoles and the longitudinal dynamics is achieved by the buncher cavities. The Dipole Steerers serve the function of a control element to achieve the desired transverse beam position. To minimize the emittance growth high magnetic field rigidity is required in a highly constrained longitudinal space for these corrector magnets. The design and development of an air-cooled dipole steerer magnet has been done for an integral dipole field of 2.1mT-m in a Good Field Region (GFR) of 23 mm diameter with Integral Field homogeneity better than 0.5%. Electromagnetic field simulations were done using 3D-FEM simulation software OPERA. Error sensitivity studies have been carried out to specify the manufacturing tolerances to estimate and minimize the beam transmission loss due to likely misalignments and rotation of the magnet. A combined function dipole corrector magnet has been designed and fabricated at the Control Instrumentation Division, BARC. This paper discusses measurement results of a combined function dipole steerer for MEBT line for Proton (H + ) beam at 2.5 MeV. (author)

  18. Primary study for boron neutron capture therapy uses the RSG-GAS beam tube facility

    International Nuclear Information System (INIS)

    Suroso

    2000-01-01

    The minimum epithermal neutron flux as one of the prerequisite of Boron Neutron Capture Therapy (BNCT) is 1.0 x 10 9 n/(cm 2 s) RSG-GAS have 6 beam tube facilities for neutron source, which is one of the beam tube S-2 has a possibility to utilization for BNCT facility. The totally flux neutron measurement in the front of S-2 beam tube is 1.8 x 10 7 n/(cm 2 s). The neutron flux measurement was less than for BNCT minimum prerequisite. Concerning to the flux neutron production in the reactor, which is reach to 2.5 x 10 14 n/(cm 2 s), there for the S-2 beam tube could be used beside collimator modification

  19. SU-E-T-323: The FLUKA Monte Carlo Code in Ion Beam Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Rinaldi, I [Heidelberg University Hospital (Germany); Ludwig-Maximilian University Munich (Germany)

    2014-06-01

    Purpose: Monte Carlo (MC) codes are increasingly used in the ion beam therapy community due to their detailed description of radiation transport and interaction with matter. The suitability of a MC code demands accurate and reliable physical models for the transport and the interaction of all components of the mixed radiation field. This contribution will address an overview of the recent developments in the FLUKA code oriented to its application in ion beam therapy. Methods: FLUKA is a general purpose MC code which allows the calculations of particle transport and interactions with matter, covering an extended range of applications. The user can manage the code through a graphic interface (FLAIR) developed using the Python programming language. Results: This contribution will present recent refinements in the description of the ionization processes and comparisons between FLUKA results and experimental data of ion beam therapy facilities. Moreover, several validations of the largely improved FLUKA nuclear models for imaging application to treatment monitoring will be shown. The complex calculation of prompt gamma ray emission compares favorably with experimental data and can be considered adequate for the intended applications. New features in the modeling of proton induced nuclear interactions also provide reliable cross section predictions for the production of radionuclides. Of great interest for the community are the developments introduced in FLAIR. The most recent efforts concern the capability of importing computed-tomography images in order to build automatically patient geometries and the implementation of different types of existing positron-emission-tomography scanner devices for imaging applications. Conclusion: The FLUA code has been already chosen as reference MC code in many ion beam therapy centers, and is being continuously improved in order to match the needs of ion beam therapy applications. Parts of this work have been supported by the European

  20. Optics measurements and transfer line matching for the SPS injection of the CERN Multi-Turn Extraction beam

    CERN Document Server

    Benedetto, E; Cettour Cave, S; Follin, F; Gilardoni, S; Giovannozzi, M; Roncarolo, F

    2010-01-01

    Dispersion and beam optics measurements were carried out in the transfer line between the CERN PS and SPS for the new Multi-Turn Extraction beam. Since the extraction conditions of the four islands and the core are different and strongly dependent on the non-linear effects used to split the beam in the transverse plane, a special care was taken during the measurement campaigns. Furthermore, an appropriate strategy was devised to minimize the overall optical mismatch at SPS injection. All this led to a new optical configuration that will be presented in the paper.

  1. Cost-effectiveness analysis of cochlear dose reduction by proton beam therapy for medulloblastoma in childhood

    International Nuclear Information System (INIS)

    Hirano, Emi; Kawabuchi, Koichi; Fuji, Hiroshi; Onoe, Tsuyoshi; Kumar, Vinay; Shirato, Hiroki

    2014-01-01

    The aim of this study is to evaluate the cost-effectiveness of proton beam therapy with cochlear dose reduction compared with conventional X-ray radiotherapy for medulloblastoma in childhood. We developed a Markov model to describe health states of 6-year-old children with medulloblastoma after treatment with proton or X-ray radiotherapy. The risks of hearing loss were calculated on cochlear dose for each treatment. Three types of health-related quality of life (HRQOL) of EQ-5D, HUI3 and SF-6D were used for estimation of quality-adjusted life years (QALYs). The incremental cost-effectiveness ratio (ICER) for proton beam therapy compared with X-ray radiotherapy was calculated for each HRQOL. Sensitivity analyses were performed to model uncertainty in these parameters. The ICER for EQ-5D, HUI3 and SF-6D were $21 716/QALY, $11 773/QALY, and $20 150/QALY, respectively. One-way sensitivity analyses found that the results were sensitive to discount rate, the risk of hearing loss after proton therapy, and costs of proton irradiation. Cost-effectiveness acceptability curve analysis revealed a 99% probability of proton therapy being cost effective at a societal willingness-to-pay value. Proton beam therapy with cochlear dose reduction improves health outcomes at a cost that is within the acceptable cost-effectiveness range from the payer's standpoint. (author)

  2. Pertinence analysis of intensity-modulated radiation therapy dosimetry error and parameters of beams

    International Nuclear Information System (INIS)

    Chi Zifeng; Liu Dan; Cao Yankun; Li Runxiao; Han Chun

    2012-01-01

    Objective: To study the relationship between parameter settings in the intensity-modulated radiation therapy (IMRT) planning in order to explore the effect of parameters on absolute dose verification. Methods: Forty-three esophageal carcinoma cases were optimized with Pinnacle 7.6c by experienced physicist using appropriate optimization parameters and dose constraints with a number of iterations to meet the clinical acceptance criteria. The plans were copied to water-phantom, 0.13 cc ion Farmer chamber and DOSE1 dosimeter was used to measure the absolute dose. The statistical data of the parameters of beams for the 43 cases were collected, and the relationships among them were analyzed. The statistical data of the dosimetry error were collected, and comparative analysis was made for the relation between the parameters of beams and ion chamber absolute dose verification results. Results: The parameters of beams were correlated among each other. Obvious affiliation existed between the dose accuracy and parameter settings. When the beam segment number of IMRT plan was more than 80, the dose deviation would be greater than 3%; however, if the beam segment number was less than 80, the dose deviation was smaller than 3%. When the beam segment number was more than 100, part of the dose deviation of this plan was greater than 4%. On the contrary, if the beam segment number was less than 100, the dose deviation was smaller than 4% definitely. Conclusions: In order to decrease the absolute dose verification error, less beam angles and less beam segments are needed and the beam segment number should be controlled within the range of 80. (authors)

  3. Beam orientation optimization for intensity modulated radiation therapy using adaptive l2,1-minimization

    International Nuclear Information System (INIS)

    Jia Xun; Men Chunhua; Jiang, Steve B; Lou Yifei

    2011-01-01

    Beam orientation optimization (BOO) is a key component in the process of intensity modulated radiation therapy treatment planning. It determines to what degree one can achieve a good treatment plan in the subsequent plan optimization process. In this paper, we have developed a BOO algorithm via adaptive l 2,1 -minimization. Specifically, we introduce a sparsity objective function term into our model which contains weighting factors for each beam angle adaptively adjusted during the optimization process. Such an objective function favors a small number of beam angles. By optimizing a total objective function consisting of a dosimetric term and the sparsity term, we are able to identify unimportant beam angles and gradually remove them without largely sacrificing the dosimetric objective. In one typical prostate case, the convergence property of our algorithm, as well as how beam angles are selected during the optimization process, is demonstrated. Fluence map optimization (FMO) is then performed based on the optimized beam angles. The resulting plan quality is presented and is found to be better than that of equiangular beam orientations. We have further systematically validated our algorithm in the contexts of 5-9 coplanar beams for five prostate cases and one head and neck case. For each case, the final FMO objective function value is used to compare the optimized beam orientations with the equiangular ones. It is found that, in the majority of cases tested, our BOO algorithm leads to beam configurations which attain lower FMO objective function values than those of corresponding equiangular cases, indicating the effectiveness of our BOO algorithm. Superior plan qualities are also demonstrated by comparing DVH curves between BOO plans and equiangular plans.

  4. Individualized Selection of Beam Angles and Treatment Isocenter in Tangential Breast Intensity Modulated Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Penninkhof, Joan, E-mail: j.penninkhof@erasmusmc.nl [Department of Radiation Oncology, Erasmus M.C. Cancer Institute, Rotterdam (Netherlands); Spadola, Sara [Department of Radiation Oncology, Erasmus M.C. Cancer Institute, Rotterdam (Netherlands); Department of Physics and Astronomy, Alma Mater Studiorum, University of Bologna, Bologna (Italy); Breedveld, Sebastiaan; Baaijens, Margreet [Department of Radiation Oncology, Erasmus M.C. Cancer Institute, Rotterdam (Netherlands); Lanconelli, Nico [Department of Physics and Astronomy, Alma Mater Studiorum, University of Bologna, Bologna (Italy); Heijmen, Ben [Department of Radiation Oncology, Erasmus M.C. Cancer Institute, Rotterdam (Netherlands)

    2017-06-01

    Purpose and Objective: Propose a novel method for individualized selection of beam angles and treatment isocenter in tangential breast intensity modulated radiation therapy (IMRT). Methods and Materials: For each patient, beam and isocenter selection starts with the fully automatic generation of a large database of IMRT plans (up to 847 in this study); each of these plans belongs to a unique combination of isocenter position, lateral beam angle, and medial beam angle. The imposed hard planning constraint on patient maximum dose may result in plans with unacceptable target dose delivery. Such plans are excluded from further analyses. Owing to differences in beam setup, database plans differ in mean doses to organs at risk (OARs). These mean doses are used to construct 2-dimensional graphs, showing relationships between: (1) contralateral breast dose and ipsilateral lung dose; and (2) contralateral breast dose and heart dose (analyzed only for left-sided). The graphs can be used for selection of the isocenter and beam angles with the optimal, patient-specific tradeoffs between the mean OAR doses. For 30 previously treated patients (15 left-sided and 15 right-sided tumors), graphs were generated considering only the clinically applied isocenter with 121 tangential beam angle pairs. For 20 of the 30 patients, 6 alternative isocenters were also investigated. Results: Computation time for automatic generation of 121 IMRT plans took on average 30 minutes. The generated graphs demonstrated large variations in tradeoffs between conflicting OAR objectives, depending on beam angles and patient anatomy. For patients with isocenter optimization, 847 IMRT plans were considered. Adding isocenter position optimization next to beam angle optimization had a small impact on the final plan quality. Conclusion: A method is proposed for individualized selection of beam angles in tangential breast IMRT. This may be especially important for patients with cardiac risk factors or an

  5. An extended range soft X-ray beam line for the 1 GeV storage ring Aladdin

    International Nuclear Information System (INIS)

    Hulbert, S.L.; Stott, J.P.; Brown, F.C.

    1983-01-01

    The design and implementation of a soft X-ray beam line on the new 1 GeV storage ring Aladdin in Stoughton, Wisconsin is discussed. The beam line consists of a long horizontally focussing collection mirror, an extended range (50-1500 eV) grasshopper monochromator, an ellipsoidal refocussing mirror, and a photoemission chamber. Also discussed are the factors considered in matching the monochromator to the storage ring, flux and performance expectations, and the results of a ray tracing analysis. (orig.)

  6. The EPICS-based remote control system for muon beam line devices at J-PARC MUSE

    Science.gov (United States)

    Ito, T. U.; Nakahara, K.; Kawase, M.; Fujimori, H.; Kobayashi, Y.; Higemoto, W.; Miyake, Y.

    2010-04-01

    The remote control system for muon beam line devices of J-PARC MUSE has been developed with the Experimental Physics and Industrial Control System (EPICS). The EPICS input/output controller was installed in standard Linux PCs for slow control of the devices. Power supplies for 21 magnetic elements and four slit controllers for the decay-surface muon beam line in the Materials and Life Science Experimental Facility are now accessible via Ethernet from a graphical user interface which has been composed using the Motif Editor and Display Manger.

  7. Dosimetry auditing procedure with alanine dosimeters for light ion beam therapy

    DEFF Research Database (Denmark)

    Ableitinger, Alexander; Vatnitsky, Stanislav; Herrmann, Rochus

    2013-01-01

    Background and purpose In the next few years the number of facilities providing ion beam therapy with scanning beams will increase. An auditing process based on an end-to-end test (including CT imaging, planning and dose delivery) could help new ion therapy centres to validate their entire logistic...... of the biological dose is out of scope of the current work. Materials and methods The audit procedure was based on a homogeneous phantom that mimics the dimension of a head (20 × 20 × 21 cm3). The phantom can be loaded either with an ionisation chamber or 20 alanine dosimeters plus 2 radiochromic EBT films. Dose...... fluence in the alanine detector. A pilot run was performed with protons and carbon ions at the Heidelberg Ion Therapy facility (HIT). Results The mean difference of the absolute physical dose measured with the alanine dosimeters compared with the expected dose from the treatment planning system was −2...

  8. Normal tissue tolerance to external beam radiation therapy: Skin

    International Nuclear Information System (INIS)

    Ginot, A.; Doyen, J.; Hannoun-Levi, J.M.; Courdi, A.

    2010-01-01

    Acute skin toxicity is frequent during radiation therapy and can lead to temporary arrest of the treatment. Chronic toxicity can occur and conduct to cosmetic problems. Alopecia is the most frequent toxicity concerning hair and is most of the time reversible. Several factors linked to patients influence skin toxicity, such as under-nutrition, old age, obesity, smoking, skin diseases, autoimmune diseases, failure of DNA reparation. Skin, hair and nail toxicities depend also on radiation schedule. Acute toxicity is greater when dose per fraction increases. Chronic and acute toxicities are more often when total dose increases. Under 45 Gy, the risk of severe skin toxicity is low, and begins above 50 Gy. Skin toxicity depends also on the duration of radiotherapy and split course schedules are associated with less toxicities. Irradiation surface seems to influence skin toxicity but interaction is more complex. Reirradiation is often feasible in case of cancer recurrence but with a risk of grade 3-4 toxicity above all in head and neck cancer. The benefit/risk ratio has to be always precisely evaluated. Permanent alopecia is correlated with the follicle dose. Modern techniques of radiation therapy allow to spare skin. (authors)

  9. The use of multi-gap resistive plate chambers for in-beam PET in proton and carbon ion therapy

    CERN Document Server

    Watts, David; Sauli, Fabio; Amaldi, Ugo

    2013-01-01

    On-line verification of the delivered dose during proton and carbon ion radiotherapy is currently a very desirable goal for quality assurance of hadron therapy treatment plans. In-beam positron emission tomography (ibPET), which can provide an image of the β+ activity induced in the patient during irradiation, which in turn is correlated to the range of the ion beam, is one of the modalities for achieving this goal. Application to hadron therapy requires that the scanner geometry be modified from that which is used in nuclear medicine. In particular, PET detectors that allow a sub-nanosecond time-of-flight (TOF) registration of the collinear photons have been proposed. Inclusion of the TOF information in PET data leads to more effective PET sensitivity. Considering the challenges inherent in the ibPET technique, namely limited β+ activity and the effect of biological washout due to blood flow, TOF-PET technologies are very attractive. In this context, the TERA Foundation is investigating the use of resistiv...

  10. Proposal of cancer therapy system without rotating gantry

    International Nuclear Information System (INIS)

    Kodaira, Masanobu

    2002-01-01

    Beam therapy is one of useful methods for cancer therapy. Many results in National Institute of Radiological Sciences (NIRS) show many abilities of beam therapy for cancer therapy. In Japan, several beam therapy facilities are constructed or under construction. If its construction budget becomes to be smaller, beam therapy may be used as the general cancer therapy. But in the present beam therapy facilities, the budget of its construction is very large. One of the reasons of big budget is the construction of the big buildings equipped with thick shielding walls. Most of space of the facilities with thick shielding walls is devoted to the treatment equipments such as rotating gantries and beam transport lines. This proposal is that using oblique beam line and rotating treatment bed, multi-portal irradiation is realized without rotating gantry. At the same time, we designed adequate beam lines to minimize the total facilities. (author)

  11. First full-beam PET acquisitions in proton therapy with a modular dual-head dedicated system

    Science.gov (United States)

    Sportelli, G.; Belcari, N.; Camarlinghi, N.; Cirrone, G. A. P.; Cuttone, G.; Ferretti, S.; Kraan, A.; Ortuño, J. E.; Romano, F.; Santos, A.; Straub, K.; Tramontana, A.; Del Guerra, A.; Rosso, V.

    2014-01-01

    During particle therapy irradiation, positron emitters with half-lives ranging from 2 to 20 min are generated from nuclear processes. The half-lives are such that it is possible either to detect the positron signal in the treatment room using an in-beam positron emission tomography (PET) system, right after the irradiation, or to quickly transfer the patient to a close PET/CT scanner. Since the activity distribution is spatially correlated with the dose, it is possible to use PET imaging as an indirect method to assure the quality of the dose delivery. In this work, we present a new dedicated PET system able to operate in-beam. The PET apparatus consists in two 10 cm × 10 cm detector heads. Each detector is composed of four scintillating matrices of 23 × 23 LYSO crystals. The crystal size is 1.9 mm × 1.9 mm × 16 mm. Each scintillation matrix is read out independently with a modularized acquisition system. The distance between the two opposing detector heads was set to 20 cm. The system has very low dead time per detector area and a 3 ns coincidence window, which is capable to sustain high single count rates and to keep the random counts relatively low. This allows a new full-beam monitoring modality that includes data acquisition also while the beam is on. The PET system was tested during the irradiation at the CATANA (INFN, Catania, Italy) cyclotron-based proton therapy facility. Four acquisitions with different doses and dose rates were analysed. In all cases the random to total coincidences ratio was equal or less than 25%. For each measurement we estimated the accuracy and precision of the activity range on a set of voxel lines within an irradiated PMMA phantom. Results show that the inclusion of data acquired during the irradiation, referred to as beam-on data, improves both the precision and accuracy of the range measurement with respect to data acquired only after irradiation. Beam-on data alone are enough to give precisions better than 1 mm

  12. First full-beam PET acquisitions in proton therapy with a modular dual-head dedicated system

    International Nuclear Information System (INIS)

    Sportelli, G; Belcari, N; Camarlinghi, N; Ferretti, S; Kraan, A; Straub, K; Guerra, A Del; Rosso, V; Cirrone, G A P; Cuttone, G; Romano, F; Tramontana, A; Ortuño, J E; Santos, A

    2014-01-01

    During particle therapy irradiation, positron emitters with half-lives ranging from 2 to 20 min are generated from nuclear processes. The half-lives are such that it is possible either to detect the positron signal in the treatment room using an in-beam positron emission tomography (PET) system, right after the irradiation, or to quickly transfer the patient to a close PET/CT scanner. Since the activity distribution is spatially correlated with the dose, it is possible to use PET imaging as an indirect method to assure the quality of the dose delivery. In this work, we present a new dedicated PET system able to operate in-beam. The PET apparatus consists in two 10 cm × 10 cm detector heads. Each detector is composed of four scintillating matrices of 23 × 23 LYSO crystals. The crystal size is 1.9 mm × 1.9 mm × 16 mm. Each scintillation matrix is read out independently with a modularized acquisition system. The distance between the two opposing detector heads was set to 20 cm. The system has very low dead time per detector area and a 3 ns coincidence window, which is capable to sustain high single count rates and to keep the random counts relatively low. This allows a new full-beam monitoring modality that includes data acquisition also while the beam is on. The PET system was tested during the irradiation at the CATANA (INFN, Catania, Italy) cyclotron-based proton therapy facility. Four acquisitions with different doses and dose rates were analysed. In all cases the random to total coincidences ratio was equal or less than 25%. For each measurement we estimated the accuracy and precision of the activity range on a set of voxel lines within an irradiated PMMA phantom. Results show that the inclusion of data acquired during the irradiation, referred to as beam-on data, improves both the precision and accuracy of the range measurement with respect to data acquired only after irradiation. Beam-on data alone are enough to give precisions better than 1

  13. Normal tissue tolerance to external beam radiation therapy: Adult bone

    International Nuclear Information System (INIS)

    Sargos, P.; Mamou, N.; Dejean, C.; Henriques de Figueiredo, B.; Kantor, G.; Huchet, A.; Italiano, A.

    2010-01-01

    Radiation tolerance for bone tissue has been mostly evaluated with regard to bone fracture. Main circumstances are mandibula osteoradionecrosis, hip and costal fracture, and patent or radiologic fractures in the treated volume. After radiation therapy of bone metastasis, the analysis of related radiation fracture is difficult to individualize from a pathologic fracture. Frequency of clinical fracture is less than 5% in the large series or cohorts and is probably under-evaluated for the asymptomatic lesions. Women older than 50 years and with osteoporosis are probably the main population at risk. Dose-effect relations are difficult to qualify in older series. Recent models evaluating radiations toxicity on diaphysa suggest an important risk after 60 Gy, for high dose-fraction and for a large volume. (authors)

  14. Normal tissue tolerance to external beam radiation therapy: The stomach

    International Nuclear Information System (INIS)

    Oberdiac, P.; Mineur, L.

    2010-01-01

    In the following article, we will discuss general issues relating to acute and late gastric's radiation toxicities. The tolerance of the stomach to complete or partial organ irradiation is more un-appreciated than for most other organs. We consulted the Medline database via PubMed and used the key words gastric - radiotherapy - toxicity. Currently, 60 Gy or less is prescribed in gastric radiation therapy. Acute clinical toxicity symptoms are predominantly nausea and vomiting. Although there is a general agreement that the whole stomach tolerance is for doses of 40 to 45 Gy without unacceptable complication, it is well established that a stomach dose of 35 Gy increases the risk of ulcer complications. (authors)

  15. Space Charge Compensation in the Linac4 Low Energy Beam Transport Line with Negative Hydrogen Ions

    CERN Document Server

    Valerio-Lizarraga, C; Leon-Monzon, I; Lettry, J; Midttun, O; Scrivens, R

    2014-01-01

    The space charge effect of low energy, unbunched ion beams can be compensated by the trapping of ions or electrons into the beam potential. This has been studied for the 45 keV negative hydrogen ion beam in the CERN Linac4 Low Energy Beam Tranport (LEBT) using the package IBSimu1, which allows the space charge calculation of the particle trajectories. The results of the beam simulations will be compared to emittance measurements of an H- beam at the CERN Linac4 3 MeV test stand, where the injection of hydrogen gas directly into the beam transport region has been used to modify the space charge compensation degree.

  16. An alternative beam line at the U-400 M cyclotron for RIB separation and transport to the FOBOS spectrometer (The technical proposal)

    International Nuclear Information System (INIS)

    Majdikov, V.Z.; Bashevoj, V.V.

    1998-01-01

    The first order ion-optic calculations performed together with the graphical modeling permits us to propose a new variant of the beam-transport line from the backside of the U-400M cyclotron to the FOBOS spectrometer. This beam line could be built in a rather short time without large financial expenditures from available magnetic and vacuum elements. The new beam line could even be considered as an economic alternative to the existing beam line and as a RIB separator. This work is the result of the pre-design R and D aimed to develop the U-400M cyclotron facilities for the RIB experiments performance with the FOBOS spectrometer

  17. Real-time dose compensation methods for scanned ion beam therapy of moving tumors

    International Nuclear Information System (INIS)

    Luechtenborg, Robert

    2012-01-01

    Scanned ion beam therapy provides highly tumor-conformal treatments. So far, only tumors showing no considerable motion during therapy have been treated as tumor motion and dynamic beam delivery interfere, causing dose deteriorations. One proposed technique to mitigate these deteriorations is beam tracking (BT), which adapts the beam position to the moving tumor. Despite application of BT, dose deviations can occur in the case of non-translational motion. In this work, real-time dose compensation combined with beam tracking (RDBT) has been implemented into the control system to compensate these dose changes by adaptation of nominal particle numbers during irradiation. Compared to BT, significantly reduced dose deviations were measured using RDBT. Treatment planning studies for lung cancer patients including the increased biological effectiveness of ions revealed a significantly reduced over-dose level (3/5 patients) as well as significantly improved dose homogeneity (4/5 patients) for RDBT. Based on these findings, real-time dose compensated re-scanning (RDRS) has been proposed that potentially supersedes the technically complex fast energy adaptation necessary for BT and RDBT. Significantly improved conformity compared to re-scanning, i.e., averaging of dose deviations by repeated irradiation, was measured in film irradiations. Simulations comparing RDRS to BT revealed reduced under- and overdoses of the former method.

  18. Proton radiation therapy for retinoblastoma: Comparison of various intraocular tumor locations and beam arrangements

    International Nuclear Information System (INIS)

    Krengli, Marco; Hug, Eugen B.; Adams, Judy A.; Smith, Alfred R.; Tarbell, Nancy J.; Munzenrider, John E.

    2005-01-01

    Purpose: To study the optimization of proton beam arrangements for various intraocular tumor locations; and to correlate isodose distributions with various target and nontarget structures. Methods and materials: We considered posterior-central, nasal, and temporal tumor locations, with straight, intrarotated, or extrarotated eye positions. Doses of 46 cobalt grey equivalent (CGE) to gross tumor volume (GTV) and 40 CGE to clinical target volume (CTV) (2 CGE per fraction) were assumed. Using three-dimensional planning, we compared isodose distributions for lateral, anterolateral oblique, and anteromedial oblique beams and dose-volume histograms of CTVs, GTVs, lens, lacrimal gland, bony orbit, and soft tissues. Results: All beam arrangements fully covered GTVs and CTVs with optimal lens sparing. Only 15% of orbital bone received doses ≥20 CGE with a lateral beam, with 20-26 CGE delivered to two of three growth centers. The anterolateral oblique approach with an intrarotated eye resulted in additional reduction of bony volume and exposure of only one growth center. No appreciable dose was delivered to the contralateral eye, brain tissue, or pituitary gland. Conclusions: Proton therapy achieved homogeneous target coverage with true lens sparing. Doses to orbit structures, including bony growth centers, were minimized with different beam arrangements and eye positions. Proton therapy could reduce the risks of second malignancy and cosmetic and functional sequelae

  19. The tension adjuster used at the work line of electron beam radiation cross-linking wire and cable

    International Nuclear Information System (INIS)

    Zhang Yingfa; Liu Zhenhao; Yin Xuejun

    1999-01-01

    The tension adjuster is an important equipment in the transport system at the work line of electron beam radiation cross-linking wire and cable to realize the velocity synchronism. There are many kinds of the adjuster. By putting various adjusters together properly, the authors can keep the line work stable and raise the quality of the product. Two kinds of standing adjuster and their mechanism are introduced. Also the corresponding figures and formulas are shown

  20. GEANT4 simulation diagram showing the architecture of the ATLAS test line: the detectors are positioned to receive the beam from the SPS. A muon particle which enters the magnet and crosses all detectors is shown (blue line).

    CERN Multimedia

    2004-01-01

    GEANT4 simulation diagram showing the architecture of the ATLAS test line: the detectors are positioned to receive the beam from the SPS. A muon particle which enters the magnet and crosses all detectors is shown (blue line).